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\title{SGDI ontology development}
\author{VJ Carey \url{stvjc@channing.harvard.edu}}
\maketitle

\section{Introduction}

This document describes tasks related to ontology
development for the SGDI (software for genomic
data integration) project.  Principal concerns 
include
\begin{itemize}
\item establishment of conventions for describing
designs of and samples from microarray experiments;
\item establishment of software tools that help
implement these conventions;
\item maximizing reuse of programatically accessible
vocabulary resources, such as those provided
by caCORE/EVS;
\item employing appropriate standards for metadata
structure design and deployment, such as RDF/OWL
models and associated XML serializations.
\end{itemize}

\section{Implementation issues}

We will distinguish three basic information structures:
\begin{itemize}
\item {\bf provenanceStruct:} a container for
information regarding the source and maintenance
of ontology-related information;
\item {\bf nomenclature:} a set of tokens representing
terms or concepts, with
specified provenance and definitions;
\item {\bf ontology:} a nomenclature with a hierarchical
structure reflecting semantic relations among the terms.
\end{itemize}

\subsection{Nomenclature example}
An example of a nomenclature structure is given here:
\begin{Schunk}
\begin{Soutput}
GDI nomenclature:  KEGGPATH 
provenance: source =  ftp://ftp.genome.ad.jp/pub/kegg/pathways/map_title.tab 
          : date =  June 30 2004 
There are 300 terms.
First 5 terms/definitions
     terms   defs                              
[1,] "07112" "1,2-Diphenyl substitution fami.."
[2,] "07113" "Furan family"                    
[3,] "07114" "Naphthalene family"              
[4,] "07115" "Sulfonamide family"              
[5,] "07116" "Butyrophenone family"            
GDI maps:
[1] "LL2KEGGmap.hsa" "LL2KEGGmap.rno"
\end{Soutput}
\end{Schunk}
The information on ``GDI maps'' pertains to usage of the
nomenclature in other information structures.  In general
it will be important to catalog not only the terms and
vocabularies in which they are used, but also the
substantive data resources in which these vocabulary
resources are deployed.  For example, in cross-organism inference,
it will be useful to be able to identify which data resources
use KEGG identifiers to characterize genomic components or
gene products.  One can then iterate over only these
resources, searching for the presence of a given
set of KEGG identifiers.
\subsection{Ontology example}
An example of an ontology is given here.  We use the
class \Rclass{taggedHierNomenclature} to emphasize
\begin{enumerate}
\item the existence of tags, which are abbreviated tokens
that are typically semantically opaque, used for abbreviated
reference to terms of interest;
\item the existence of hierarchical semantic relationships
among terms;
\item the extension of the formal nomenclature class.
\end{enumerate}
The data resource in this example is the NCI \textit{Thesaurus},
as opposed to the \textit{Metathesaurus}.  The thesaurus
is made available to support ontological inference in ways
that are not straightforward for the metathesaurus at this time.
\begin{Schunk}
\begin{Sinput}
> data(GDI_NCIThesaurus)
> GDI_NCIThesaurus
\end{Sinput}
\begin{Soutput}
An object of class "taggedHierNomenclature"
Slot "name":
[1] "NCIThesaurus"
Slot "provenance":
An object of class "provStruct"
Slot "URI":
[1] "ftp://ftp1.nci.nih.gov/pub/cacore/EVS/Thesaurus_04.06i.FLAT.zip"
Slot "captureDate":
[1] "Oct 15 2004"
Slot "inMappings":
character(0)
Slot "terms":
    [1] "Combination_Chemotherapy"                                                                                                                                             
    [2] "Mesna"                                                                                                                                                                
    [3] "_3-Deazauridine"                                                                                                                                                      
    [4] "_4-Nitroquinoline-1-Oxide"                                                                                                                                            
    [5] "Mercaptopurine"                                                                                                                                                       
    [6] "Benzo_a_pyrene-7_8-diol_9_10-Epoxide"                                                                                                                                 
    [7] "Dimethylbenzanthracene"                                                                                                                                               
    [8] "Acetaminophen"                                                                                                                                                        
    [9] "Acetyl_Coenzyme_A"                                                                                                                                                    
   [10] "Acetylcysteine"                                                                                                                                                       
   [11] "Muramyl_Dipeptide"                                                                                                                                                    
   [12] "Aclarubicin"                                                                                                                                                          
   [13] "Acridine"                                                                                                                                                             
   [14] "Actinomycin_Antibiotic"                                                                                                                                               
   [15] "Acyclovir"                                                                                                                                                            
   [16] "Adenine"                                                                                                                                                              
   [17] "Adenosine"                                                                                                                                                            
   [18] "Cyclic_AMP"                                                                                                                                                           
   [19] "Adenosine_Triphosphate"                                                                                                                                               
   [20] "Immunoadjuvant"                                                                                                                                                       
   [21] "Therapeutic_Corticosteroid"                                                                                                                                           
   [22] "Therapeutic_Corticotropin"                                                                                                                                            
   [23] "Aflatoxin"                                                                                                                                                            
   [24] "Albumin"                                                                                                                                                              
   [25] "Albuterol"                                                                                                                                                            
   [26] "Ethanol"                                                                                                                                                              
   [27] "Methanol"                                                                                                                                                             
   [28] "Alcohol_Chemical_Class"                                                                                                                                               
   [29] "Aldosterone"                                                                                                                                                          
   [30] "Alfentanil_Hydrochloride"                                                                                                                                             
   [31] "Alkaloid"                                                                                                                                                             
   [32] "Alkylsulfonate_Compound"                                                                                                                                              
   [33] "Alkylating_Agent"                                                                                                                                                     
   [34] "Allopurinol"                                                                                                                                                          
   [35] "Therapeutic_Interferon_Alfa"                                                                                                                                          
   [36] "Eflornithine"                                                                                                                                                         
   [37] "Alprazolam"                                                                                                                                                           
   [38] "Alum_Adjuvant"                                                                                                                                                        
   [39] "Americium"                                                                                                                                                            
   [40] "Amikacin"                                                                                                                                                             
   [41] "Amino_Acid"                                                                                                                                                           
   [42] "Amino_Acid_Peptide_or_Protein"                                                                                                                                        
   [43] "Aminoglutethimide"                                                                                                                                                    
   [44] "Aminolevulinic_Acid"                                                                                                                                                  
   [45] "Aminopterin"                                                                                                                                                          
   [46] "Amiodarone"                                                                                                                                                           
   [47] "Amoxicillin"                                                                                                                                                          
   [48] "Amphotercin_B"                                                                                                                                                        
   [49] "Ampicillin"                                                                                                                                                           
   [50] "Amsacrine"                                                                                                                                                            
   [51] "Analgesic_Agent"                                                                                                                                                      
   [52] "Anti-Androgen"                                                                                                                                                        
   [53] "Therapeutic_Androgen"                                                                                                                                                 
   [54] "Therapeutic_Androstenedione"                                                                                                                                          
   [55] "Anesthetic_Agent"                                                                                                                                                     
   [56] "Anethole_Trithione"                                                                                                                                                   
   [57] "ACE_Inhibitor"                                                                                                                                                        
   [58] "Angiotensin"                                                                                                                                                          
   [59] "Aniline_Mustard"                                                                                                                                                      
   [60] "Antihelminthic_Agent"                                                                                                                                                 
   [61] "Anthracene"                                                                                                                                                           
   [62] "Anthramycin"                                                                                                                                                          
   [63] "Anthraquinone_Compound"                                                                                                                                               
   [64] "Anti-Infective_Agent"                                                                                                                                                 
   [65] "Urinary_Anti-Infective_Agent"                                                                                                                                         
   [66] "Anti-Inflammatory_Agent"                                                                                                                                              
   [67] "Nonsteroidal_Antiinflammatory_Drug"                                                                                                                                   
   [68] "Antibiotic"                                                                                                                                                           
   [69] "Antineoplastic_Antibiotic"                                                                                                                                            
   [70] "Beta-Lactam_Antibiotic"                                                                                                                                               
   [71] "Macrolide_Antibiotic"                                                                                                                                                 
   [72] "Monoclonal_Antibody_Therapeutic"                                                                                                                                      
   [73] "Anticoagulant_Agent"                                                                                                                                                  
   [74] "Anticonvulsant_Agent"                                                                                                                                                 
   [75] "Antidepressant_Agent"                                                                                                                                                 
   [76] "Antidiarrheal_Agent"                                                                                                                                                  
   [77] "Antiemetic_Agent"                                                                                                                                                     
   [78] "Antigen"                                                                                                                                                              
   [79] "Cell_Surface_Antigen"                                                                                                                                                 
   [80] "Antihypertensive_Agent"                                                                                                                                               
   [81] "Antimalarial_Agent"                                                                                                                                                   
   [82] "Antimetabolite"                                                                                                                                                       
   [83] "Antimitotic_Agent"                                                                                                                                                    
   [84] "Antineoplastic_Agent"                                                                                                                                                 
   [85] "Antioxidant"                                                                                                                                                          
   [86] "Antiparasitic_Agent"                                                                                                                                                  
   [87] "Antiprotozoal_Agent"                                                                                                                                                  
   [88] "Antithymocyte_Globulin"                                                                                                                                               
   [89] "Trichomonacide_Agent"                                                                                                                                                 
   [90] "Antitubercular_Agent"                                                                                                                                                 
   [91] "Antiviral_Agent"                                                                                                                                                      
   [92] "Arachidonic_Acid"                                                                                                                                                     
   [93] "Artificial_Sweetener"                                                                                                                                                 
   [94] "Asbestos"                                                                                                                                                             
   [95] "Ascorbic_Acid"                                                                                                                                                        
   [96] "Asparaginase"                                                                                                                                                         
   [97] "Acetylsalicylic_Acid"                                                                                                                                                 
   [98] "Azacitidine"                                                                                                                                                          
   [99] "Azaserine"                                                                                                                                                            
  [100] "Azathioprine"                                                                                                                                                         
  [101] "_6-Azauridine"                                                                                                                                                        
  [102] "Ethylenimine_Compound"                                                                                                                                                
  [103] "Azlocillin"                                                                                                                                                           
  [104] "Azoxymethane"                                                                                                                                                         
  [105] "Bacitracin"                                                                                                                                                           
  [106] "Bacterial_Toxin"                                                                                                                                                      
  [107] "Batrachotoxin"                                                                                                                                                        
  [108] "BCG_Vaccine"                                                                                                                                                          
  [109] "Beclomethasone"                                                                                                                                                       
  [110] "Diphenhydramine_Hydrochloride"                                                                                                                                        
  [111] "Bence_Jones_Protein"                                                                                                                                                  
  [112] "Benzene"                                                                                                                                                              
  [113] "Betamethasone"                                                                                                                                                        
  [114] "Bile_Pigment"                                                                                                                                                         
  [115] "Bilirubin"                                                                                                                                                            
  [116] "Bioflavonoid"                                                                                                                                                         
  [117] "Biological_Agent"                                                                                                                                                     
  [118] "Biological_Response_Modifier"                                                                                                                                         
  [119] "Biotin"                                                                                                                                                               
  [120] "Dicumarol"                                                                                                                                                            
  [121] "Bleomycin_A2"                                                                                                                                                         
  [122] "Bleomycin_Sulphate"                                                                                                                                                   
  [123] "Bleomycin"                                                                                                                                                            
  [124] "Blood_Substitute"                                                                                                                                                     
  [125] "Bombesin"                                                                                                                                                             
  [126] "Bradykinin"                                                                                                                                                           
  [127] "Bromocriptine"                                                                                                                                                        
  [128] "Bromodeoxyuridine"                                                                                                                                                    
  [129] "Bronchodilator"                                                                                                                                                       
  [130] "Buserelin"                                                                                                                                                            
  [131] "Busulfan"                                                                                                                                                             
  [132] "BHT"                                                                                                                                                                  
  [133] "Butyrophenone"                                                                                                                                                        
  [134] "cDNA"                                                                                                                                                                 
  [135] "CA-125_Antigen"                                                                                                                                                       
  [136] "Mucin_Peptide_MUC-1"                                                                                                                                                  
  [137] "CA19-9_Antigen"                                                                                                                                                       
  [138] "Caffeine"                                                                                                                                                             
  [139] "Therapeutic_Calcitonin"                                                                                                                                               
  [140] "Calcitriol"                                                                                                                                                           
  [141] "Calcium"                                                                                                                                                              
  [142] "Calcium_Carbonate"                                                                                                                                                    
  [143] "Calcium_Channel_Blocker"                                                                                                                                              
  [144] "Edetate_Calcium_Disodium"                                                                                                                                             
  [145] "Calcium_Glucarate"                                                                                                                                                    
  [146] "Calcium_Gluconate"                                                                                                                                                    
  [147] "Calusterone"                                                                                                                                                          
  [148] "Camptothecin"                                                                                                                                                         
  [149] "Capsaicin"                                                                                                                                                            
  [150] "Captopril"                                                                                                                                                            
  [151] "Carbamazepine"                                                                                                                                                        
  [152] "Carboquone"                                                                                                                                                           
  [153] "Carbenicillin"                                                                                                                                                        
  [154] "Carbohydrate"                                                                                                                                                         
  [155] "Carboxylic_Acids"                                                                                                                                                     
  [156] "Carboxypeptidase-G2"                                                                                                                                                  
  [157] "Carcinogen"                                                                                                                                                           
  [158] "Environmental_Carcinogen"                                                                                                                                             
  [159] "Carmustine"                                                                                                                                                           
  [160] "Carotene"                                                                                                                                                             
  [161] "Carotenoid"                                                                                                                                                           
  [162] "Carubicin"                                                                                                                                                            
  [163] "Cefamandole"                                                                                                                                                          
  [164] "Cefotaxime"                                                                                                                                                           
  [165] "Ceftazidime"                                                                                                                                                          
  [166] "Cephalexin"                                                                                                                                                           
  [167] "Cephalosporin_Antibiotic"                                                                                                                                             
  [168] "Cephalothin"                                                                                                                                                          
  [169] "Ceramide"                                                                                                                                                             
  [170] "Chelating_Agent"                                                                                                                                                      
  [171] "Chewing_Tobacco"                                                                                                                                                      
  [172] "Chlorambucil"                                                                                                                                                         
  [173] "Chloramphenicol"                                                                                                                                                      
  [174] "Chlorhexidine"                                                                                                                                                        
  [175] "Chlormadinone_Acetate"                                                                                                                                                
  [176] "Chlorophyll"                                                                                                                                                          
  [177] "Chlorpromazine"                                                                                                                                                       
  [178] "Cholera_Toxin"                                                                                                                                                        
  [179] "Cholesterol"                                                                                                                                                          
  [180] "Chromium"                                                                                                                                                             
  [181] "Chromomycin_Antibiotic"                                                                                                                                               
  [182] "Chrysarobin"                                                                                                                                                          
  [183] "Chrysenes"                                                                                                                                                            
  [184] "Cimetidine"                                                                                                                                                           
  [185] "Ciprofloxacin"                                                                                                                                                        
  [186] "Cisplatin"                                                                                                                                                            
  [187] "Clindamycin"                                                                                                                                                          
  [188] "Clofibrate"                                                                                                                                                           
  [189] "Clomiphene"                                                                                                                                                           
  [190] "Clonidine"                                                                                                                                                            
  [191] "Clotrimazole"                                                                                                                                                         
  [192] "Cobalt"                                                                                                                                                               
  [193] "Codeine"                                                                                                                                                              
  [194] "Coenzyme_A"                                                                                                                                                           
  [195] "Colchicine"                                                                                                                                                           
  [196] "Colistin_Sulfate"                                                                                                                                                     
  [197] "Therapeutic_Colony_Stimulating_Factor"                                                                                                                                
  [198] "Therapeutic_C5a"                                                                                                                                                      
  [199] "Oral_Contraceptive"                                                                                                                                                   
  [200] "Contrast_Agent"                                                                                                                                                       
  [201] "Copper"                                                                                                                                                               
  [202] "Corn_Oil"                                                                                                                                                             
  [203] "Corticosterone"                                                                                                                                                       
  [204] "Therapeutic_Corticotropin_Releasing_Factor"                                                                                                                           
  [205] "Therapeutic_Cortisone"                                                                                                                                                
  [206] "Cosmid_Vector"                                                                                                                                                        
  [207] "Coumarin"                                                                                                                                                             
  [208] "Diltiazem_Hydrochloride"                                                                                                                                              
  [209] "Creatinine"                                                                                                                                                           
  [210] "Crotoxin"                                                                                                                                                             
  [211] "Curcumin"                                                                                                                                                             
  [212] "Cyanogen_Bromide"                                                                                                                                                     
  [213] "Ancitabine_Hydrochloride"                                                                                                                                             
  [214] "Cycloleucine"                                                                                                                                                         
  [215] "Cyclophosphamide"                                                                                                                                                     
  [216] "Cyclosporine"                                                                                                                                                         
  [217] "Cyproterone"                                                                                                                                                          
  [218] "Cytosine_Arabinoside"                                                                                                                                                 
  [219] "Cytidine"                                                                                                                                                             
  [220] "Cytosine"                                                                                                                                                             
  [221] "Dacarbazine"                                                                                                                                                          
  [222] "Dactinomycin"                                                                                                                                                         
  [223] "Dairy_Product"                                                                                                                                                        
  [224] "Danazol"                                                                                                                                                              
  [225] "Dapsone"                                                                                                                                                              
  [226] "Deferoxamine"                                                                                                                                                         
  [227] "Deferoxamine_Mesylate"                                                                                                                                                
  [228] "Dehydroemetine"                                                                                                                                                       
  [229] "Demecolcine"                                                                                                                                                          
  [230] "Deoxycytidine"                                                                                                                                                        
  [231] "Deoxyguanosine"                                                                                                                                                       
  [232] "Dexamethasone"                                                                                                                                                        
  [233] "Dextromethorphan"                                                                                                                                                     
  [234] "Heroin"                                                                                                                                                               
  [235] "Dianhydrogalactitol"                                                                                                                                                  
  [236] "Diazonium_Compounds"                                                                                                                                                  
  [237] "Diazooxonorleucine"                                                                                                                                                   
  [238] "Diazoxide"                                                                                                                                                            
  [239] "Dideoxyadenosine"                                                                                                                                                     
  [240] "Zalcitabine"                                                                                                                                                          
  [241] "Didanosine"                                                                                                                                                           
  [242] "Diethyldithiocarbamate"                                                                                                                                               
  [243] "Diethylstilbestrol"                                                                                                                                                   
  [244] "Digestant"                                                                                                                                                            
  [245] "Diacylglycerol"                                                                                                                                                       
  [246] "Hydromorphone"                                                                                                                                                        
  [247] "Dimethyl_Sulfoxide"                                                                                                                                                   
  [248] "Dimethylhydrazines"                                                                                                                                                   
  [249] "Dinitrochlorobenzene"                                                                                                                                                 
  [250] "Dinitrofluorobenzene"                                                                                                                                                 
  [251] "Dinitrophenyl_Compounds"                                                                                                                                              
  [252] "Dioxin_Compound"                                                                                                                                                      
  [253] "Biphosphonate"                                                                                                                                                        
  [254] "Diphtheria_Toxin"                                                                                                                                                     
  [255] "Dipyridamole"                                                                                                                                                         
  [256] "Distamycin_Antibiotic"                                                                                                                                                
  [257] "Disulfiram"                                                                                                                                                           
  [258] "Diuretic"                                                                                                                                                             
  [259] "Deoxyribonucleic_Acid"                                                                                                                                                
  [260] "DNA_Insertion_Elements"                                                                                                                                               
  [261] "DNA_Probes"                                                                                                                                                           
  [262] "HPV_DNA_Probes"                                                                                                                                                       
  [263] "Recombinant_DNA"                                                                                                                                                      
  [264] "Domperidone"                                                                                                                                                          
  [265] "Dopamine"                                                                                                                                                             
  [266] "Doxorubicin"                                                                                                                                                          
  [267] "Doxycycline"                                                                                                                                                          
  [268] "Droperidol"                                                                                                                                                           
  [269] "Medication"                                                                                                                                                           
  [270] "Pentetic_Acid"                                                                                                                                                        
  [271] "Dye"                                                                                                                                                                  
  [272] "Echinomycin"                                                                                                                                                          
  [273] "Eicosanoid"                                                                                                                                                           
  [274] "Electrolytes"                                                                                                                                                         
  [275] "Radioactive_Element"                                                                                                                                                  
  [276] "Emodin"                                                                                                                                                               
  [277] "Emollient"                                                                                                                                                            
  [278] "Enalapril"                                                                                                                                                            
  [279] "Endorphin"                                                                                                                                                            
  [280] "Enterotoxin"                                                                                                                                                          
  [281] "Enzyme_Inhibitor"                                                                                                                                                     
  [282] "Ephedrine"                                                                                                                                                            
  [283] "Therapeutic_Epinephrine"                                                                                                                                              
  [284] "Epirubicin"                                                                                                                                                           
  [285] "Epoxide_Compound"                                                                                                                                                     
  [286] "Erythromycin"                                                                                                                                                         
  [287] "Recombinant_Erythropoietin"                                                                                                                                           
  [288] "Therapeutic_Estradiol"                                                                                                                                                
  [289] "Estramustine"                                                                                                                                                         
  [290] "Estramustine_Phosphate_Sodium"                                                                                                                                        
  [291] "Antiestrogen"                                                                                                                                                         
  [292] "Conjugated_Estrogens"                                                                                                                                                 
  [293] "Therapeutic_Estrogen"                                                                                                                                                 
  [294] "Therapeutic_Estrone"                                                                                                                                                  
  [295] "Ethacrynic_Acid"                                                                                                                                                      
  [296] "Ethinyl_Estradiol"                                                                                                                                                    
  [297] "Ethiodized_Oil"                                                                                                                                                       
  [298] "Amifostine"                                                                                                                                                           
  [299] "Etoglucid"                                                                                                                                                            
  [300] "Ethylene_Dibromide"                                                                                                                                                   
  [301] "Etoposide"                                                                                                                                                            
  [302] "Fatty_Acid"                                                                                                                                                           
  [303] "Omega-3_Fatty_Acid"                                                                                                                                                   
  [304] "Fentanyl"                                                                                                                                                             
  [305] "Therapeutic_Interferon_Beta"                                                                                                                                          
  [306] "Therapeutic_Fibroblast_Growth_Factor"                                                                                                                                 
  [307] "Fish_Oil"                                                                                                                                                             
  [308] "Fixative"                                                                                                                                                             
  [309] "Flecainide"                                                                                                                                                           
  [310] "Fluconazole"                                                                                                                                                          
  [311] "Flucytosine"                                                                                                                                                          
  [312] "Fluorine"                                                                                                                                                             
  [313] "Fluorochrome"                                                                                                                                                         
  [314] "Floxuridine"                                                                                                                                                          
  [315] "Fluorouracil"                                                                                                                                                         
  [316] "Fluoxetine"                                                                                                                                                           
  [317] "Fluoxymesterone"                                                                                                                                                      
  [318] "Flurbiprofen"                                                                                                                                                         
  [319] "Flutamide"                                                                                                                                                            
  [320] "Folic_Acid"                                                                                                                                                           
  [321] "Folate_Antagonist"                                                                                                                                                    
  [322] "Free_Radicals"                                                                                                                                                        
  [323] "Tegafur"                                                                                                                                                              
  [324] "Antifungal_Agent"                                                                                                                                                     
  [325] "Furosemide"                                                                                                                                                           
  [326] "Ganglioside_GM2"                                                                                                                                                      
  [327] "Ganciclovir"                                                                                                                                                          
  [328] "Ganglioside"                                                                                                                                                          
  [329] "Gentamicin"                                                                                                                                                           
  [330] "Therapeutic_Glucagon"                                                                                                                                                 
  [331] "Therapeutic_Glucocorticoid"                                                                                                                                           
  [332] "Glutamine"                                                                                                                                                            
  [333] "Glutathione"                                                                                                                                                          
  [334] "Glycine"                                                                                                                                                              
  [335] "Glycophorin_A_Protein"                                                                                                                                                
  [336] "Glycyrrhetic_Acid"                                                                                                                                                    
  [337] "Therapeutic_Gonadotropin"                                                                                                                                             
  [338] "Therapeutic_Human_Chorionic_Gonadotropin"                                                                                                                             
  [339] "Gossypol"                                                                                                                                                             
  [340] "Therapeutic_Growth_Factor"                                                                                                                                            
  [341] "Guanazole"                                                                                                                                                            
  [342] "Guanine"                                                                                                                                                              
  [343] "Guanosine"                                                                                                                                                            
  [344] "Cyclic_GMP"                                                                                                                                                           
  [345] "GDP"                                                                                                                                                                  
  [346] "GTP"                                                                                                                                                                  
  [347] "Haloperidol"                                                                                                                                                          
  [348] "Hemes"                                                                                                                                                                
  [349] "Heparin"                                                                                                                                                              
  [350] "Heparan_Sulfate"                                                                                                                                                      
  [351] "Herbicide"                                                                                                                                                            
  [352] "Heterocyclic_Compound"                                                                                                                                                
  [353] "_2-Ring_Heterocyclic_Compound"                                                                                                                                        
  [354] "Altretamine"                                                                                                                                                          
  [355] "Hexestrol"                                                                                                                                                            
  [356] "Pibenzimol"                                                                                                                                                           
  [357] "Hormone_Antagonist"                                                                                                                                                   
  [358] "Therapeutic_Hormone"                                                                                                                                                  
  [359] "Hyaluronic_Acid"                                                                                                                                                      
  [360] "Hycanthone"                                                                                                                                                           
  [361] "Hydralazine"                                                                                                                                                          
  [362] "Hydrocarbon"                                                                                                                                                          
  [363] "Aromatic_Hydrocarbon"                                                                                                                                                 
  [364] "Halogenated_Hydrocarbon"                                                                                                                                              
  [365] "Therapeutic_Hydrocortisone"                                                                                                                                           
  [366] "Hydroxamic_Acids"                                                                                                                                                     
  [367] "Hydroxychloroquine"                                                                                                                                                   
  [368] "Hydroxyeicosatetraenoic_Acid"                                                                                                                                         
  [369] "Hetastarch"                                                                                                                                                           
  [370] "Hydroxyurea"                                                                                                                                                          
  [371] "Ibuprofen"                                                                                                                                                            
  [372] "Idarubicin"                                                                                                                                                           
  [373] "Idoxuridine"                                                                                                                                                          
  [374] "Ifosfamide"                                                                                                                                                           
  [375] "IgA"                                                                                                                                                                  
  [376] "IgD"                                                                                                                                                                  
  [377] "IgE"                                                                                                                                                                  
  [378] "IgG"                                                                                                                                                                  
  [379] "IgM"                                                                                                                                                                  
  [380] "Imipenem"                                                                                                                                                             
  [381] "Antiserum"                                                                                                                                                            
  [382] "Immunoglobulin"                                                                                                                                                       
  [383] "Surface_Immunoglobulin"                                                                                                                                               
  [384] "Immunosuppressant"                                                                                                                                                    
  [385] "Immunotoxin"                                                                                                                                                          
  [386] "Indomethacin"                                                                                                                                                         
  [387] "Industrial_Waste"                                                                                                                                                     
  [388] "Recombinant_Inhibins"                                                                                                                                                 
  [389] "Inorganic_Chemical"                                                                                                                                                   
  [390] "Inositol_1_4_5-Trisphosphate"                                                                                                                                         
  [391] "Therapeutic_Insulin"                                                                                                                                                  
  [392] "Intercalating_Agent"                                                                                                                                                  
  [393] "Therapeutic_Interferon_Gamma"                                                                                                                                         
  [394] "Therapeutic_Interferon"                                                                                                                                               
  [395] "Recombinant_Interleukin-1-beta"                                                                                                                                       
  [396] "Therapeutic_Interleukin-1"                                                                                                                                            
  [397] "Therapeutic_Interleukin-2"                                                                                                                                            
  [398] "Therapeutic_Interleukin-3"                                                                                                                                            
  [399] "Therapeutic_Interleukin-4"                                                                                                                                            
  [400] "Therapeutic_Interleukin-5"                                                                                                                                            
  [401] "Therapeutic_Interleukin-6"                                                                                                                                            
  [402] "Therapeutic_Interleukin-7"                                                                                                                                            
  [403] "Therapeutic_Interleukin"                                                                                                                                              
  [404] "Iodine"                                                                                                                                                               
  [405] "Iodotyrosine"                                                                                                                                                         
  [406] "Ionomycin"                                                                                                                                                            
  [407] "Ions"                                                                                                                                                                 
  [408] "Iron"                                                                                                                                                                 
  [409] "Isoflavone"                                                                                                                                                           
  [410] "Isoniazid"                                                                                                                                                            
  [411] "Inosine_Pranobex"                                                                                                                                                     
  [412] "Isopropanol"                                                                                                                                                          
  [413] "Isotretinoin"                                                                                                                                                         
  [414] "Ketanserin"                                                                                                                                                           
  [415] "Ketoconazole"                                                                                                                                                         
  [416] "Lactone_Compound"                                                                                                                                                     
  [417] "Leucovorin_Calcium"                                                                                                                                                   
  [418] "Leukotriene"                                                                                                                                                          
  [419] "Leukotriene_B4"                                                                                                                                                       
  [420] "Levamisole"                                                                                                                                                           
  [421] "Levodopa"                                                                                                                                                             
  [422] "Therapeutic_Luteinizing_Hormone"                                                                                                                                      
  [423] "Therapeutic_Gonadorelin"                                                                                                                                              
  [424] "Lidocaine"                                                                                                                                                            
  [425] "Linoleic_Acid"                                                                                                                                                        
  [426] "Lipid"                                                                                                                                                                
  [427] "Lomustine"                                                                                                                                                            
  [428] "Loperamide"                                                                                                                                                           
  [429] "Lorazepam"                                                                                                                                                            
  [430] "Lovastatin"                                                                                                                                                           
  [431] "Therapeutic_Lymphokine"                                                                                                                                               
  [432] "Therapeutic_Tumor_Necrosis_Factor-Beta"                                                                                                                               
  [433] "Magnesium_Sulfate"                                                                                                                                                    
  [434] "Manganese"                                                                                                                                                            
  [435] "Mannitol"                                                                                                                                                             
  [436] "Maytansine"                                                                                                                                                           
  [437] "Nitrogen_Mustard"                                                                                                                                                     
  [438] "Mechlorethamine_Oxide_Hydrochloride"                                                                                                                                  
  [439] "Medroxyprogesterone"                                                                                                                                                  
  [440] "Megestrol"                                                                                                                                                            
  [441] "Melanin"                                                                                                                                                              
  [442] "Therapeutic_Melatonin"                                                                                                                                                
  [443] "Melphalan"                                                                                                                                                            
  [444] "Therapeutic_Human_Menopausal_Gonadotropin"                                                                                                                            
  [445] "Meperidine"                                                                                                                                                           
  [446] "Mestranol"                                                                                                                                                            
  [447] "Metals"                                                                                                                                                               
  [448] "Methadone"                                                                                                                                                            
  [449] "Mesylates"                                                                                                                                                            
  [450] "Methaqualone"                                                                                                                                                         
  [451] "Methimazole"                                                                                                                                                          
  [452] "Methotrexate"                                                                                                                                                         
  [453] "Methoxsalen"                                                                                                                                                          
  [454] "Methylene_Blue"                                                                                                                                                       
  [455] "Methylnitrosourea"                                                                                                                                                    
  [456] "Methylphenidate"                                                                                                                                                      
  [457] "Methylprednisolone"                                                                                                                                                   
  [458] "Methyltestosterone"                                                                                                                                                   
  [459] "Metoclopramide"                                                                                                                                                       
  [460] "Metolazone"                                                                                                                                                           
  [461] "Metronidazole"                                                                                                                                                        
  [462] "Mexiletine"                                                                                                                                                           
  [463] "Mezlocillin"                                                                                                                                                          
  [464] "Midazolam"                                                                                                                                                            
  [465] "Mifepristone"                                                                                                                                                         
  [466] "Mineral"                                                                                                                                                              
  [467] "Misonidazole"                                                                                                                                                         
  [468] "Plicamycin"                                                                                                                                                           
  [469] "Mitobronitol"                                                                                                                                                         
  [470] "Mitogen"                                                                                                                                                              
  [471] "Mitoguazone"                                                                                                                                                          
  [472] "Mitolactol"                                                                                                                                                           
  [473] "Mitomycin_Antibiotic"                                                                                                                                                 
  [474] "Mitotane"                                                                                                                                                             
  [475] "Mitoxantrone"                                                                                                                                                         
  [476] "Molybdenum"                                                                                                                                                           
  [477] "Monoamine_Oxidase_Inhibitor"                                                                                                                                          
  [478] "Mopidamol"                                                                                                                                                            
  [479] "Morphine"                                                                                                                                                             
  [480] "Moxalactam"                                                                                                                                                           
  [481] "Bischloroethylsulfide"                                                                                                                                                
  [482] "Mutagen"                                                                                                                                                              
  [483] "Mycophenolic_Acid"                                                                                                                                                    
  [484] "Mycotoxin"                                                                                                                                                            
  [485] "NAD"                                                                                                                                                                  
  [486] "NADP"                                                                                                                                                                 
  [487] "Nafoxidine"                                                                                                                                                           
  [488] "Naloxone"                                                                                                                                                             
  [489] "Naltrexone"                                                                                                                                                           
  [490] "Naproxen"                                                                                                                                                             
  [491] "Opiate_Antagonist"                                                                                                                                                    
  [492] "Zinostatin"                                                                                                                                                           
  [493] "Neomycin"                                                                                                                                                             
  [494] "Therapeutic_Nerve_Growth_Factor"                                                                                                                                      
  [495] "Neuropeptide-Y"                                                                                                                                                       
  [496] "Neuropeptide"                                                                                                                                                         
  [497] "Neurotransmitter"                                                                                                                                                     
  [498] "Neurotoxin"                                                                                                                                                           
  [499] "Niacin"                                                                                                                                                               
  [500] "Nickel"                                                                                                                                                               
  [501] "Nicotine"                                                                                                                                                             
  [502] "Nimodipine"                                                                                                                                                           
  [503] "Nimustine"                                                                                                                                                            
  [504] "Nitracrine"                                                                                                                                                           
  [505] "Nitric_Oxide"                                                                                                                                                         
  [506] "Nitriles"                                                                                                                                                             
  [507] "Nitrogen_Mustard_Compound"                                                                                                                                            
  [508] "Nitrosamines"                                                                                                                                                         
  [509] "Nitrosourea_Compound"                                                                                                                                                 
  [510] "Nogalamycin"                                                                                                                                                          
  [511] "Nordihydroguaiaretic_Acid"                                                                                                                                            
  [512] "Norethindrone"                                                                                                                                                        
  [513] "Norgestrel"                                                                                                                                                           
  [514] "Nortriptyline"                                                                                                                                                        
  [515] "Novobiocin"                                                                                                                                                           
  [516] "Nucleic_Acids"                                                                                                                                                        
  [517] "Nucleoside"                                                                                                                                                           
  [518] "Nucleic_Acids_Nucleosides_and_Nucleotides"                                                                                                                            
  [519] "Nucleotides"                                                                                                                                                          
  [520] "Nystatin"                                                                                                                                                             
  [521] "Octreotide"                                                                                                                                                           
  [522] "Ofloxacin"                                                                                                                                                            
  [523] "Oligonucleotide"                                                                                                                                                      
  [524] "Oligosaccharide"                                                                                                                                                      
  [525] "Olivomycin_Antibiotic"                                                                                                                                                
  [526] "Omeprazole"                                                                                                                                                           
  [527] "Oncolytic_Virus"                                                                                                                                                      
  [528] "Organic_Chemical"                                                                                                                                                     
  [529] "Organometallic_Compound"                                                                                                                                              
  [530] "Oxacillin"                                                                                                                                                            
  [531] "OxyContin"                                                                                                                                                            
  [532] "Oxygen"                                                                                                                                                               
  [533] "Oxymetholone"                                                                                                                                                         
  [534] "Therapeutic_Oxytocin"                                                                                                                                                 
  [535] "Pancreatic_Polypeptide"                                                                                                                                               
  [536] "Papaverine"                                                                                                                                                           
  [537] "Paraffin"                                                                                                                                                             
  [538] "Pefloxacin"                                                                                                                                                           
  [539] "Penicillamine"                                                                                                                                                        
  [540] "Penicillin_V"                                                                                                                                                         
  [541] "Pentamidine"                                                                                                                                                          
  [542] "Pentostatin"                                                                                                                                                          
  [543] "Pentoxifylline"                                                                                                                                                       
  [544] "Peptichemio"                                                                                                                                                          
  [545] "Peptide"                                                                                                                                                              
  [546] "Pertussis_Toxin"                                                                                                                                                      
  [547] "Pesticide"                                                                                                                                                            
  [548] "Phencyclidine"                                                                                                                                                        
  [549] "Phenobarbital"                                                                                                                                                        
  [550] "Phenothiazine"                                                                                                                                                        
  [551] "Phenytoin"                                                                                                                                                            
  [552] "Phorbol_Ester"                                                                                                                                                        
  [553] "Phosphatidylinositol"                                                                                                                                                 
  [554] "Phosphodiesterase_Inhibitor"                                                                                                                                          
  [555] "OK-432"                                                                                                                                                               
  [556] "Picoline_Compound"                                                                                                                                                    
  [557] "Pigment"                                                                                                                                                              
  [558] "Pilocarpine"                                                                                                                                                          
  [559] "Piperacillin"                                                                                                                                                         
  [560] "Pipobroman"                                                                                                                                                           
  [561] "Piroxicam"                                                                                                                                                            
  [562] "Pituitary_Hormone"                                                                                                                                                    
  [563] "Placebo"                                                                                                                                                              
  [564] "Plasmid"                                                                                                                                                              
  [565] "Therapeutic_Platlet-Derived_Growth_Factor"                                                                                                                            
  [566] "Platinum"                                                                                                                                                             
  [567] "Poly_AU"                                                                                                                                                              
  [568] "Poly_IC"                                                                                                                                                              
  [569] "Polyamine_Compound"                                                                                                                                                   
  [570] "Polychlorinated_Biphenyl"                                                                                                                                             
  [571] "Polycyclic_Aromatic_Hydrocarbons"                                                                                                                                     
  [572] "Polyethylene_Glycol"                                                                                                                                                  
  [573] "Porfiromycin"                                                                                                                                                         
  [574] "Porphyrin"                                                                                                                                                            
  [575] "Potassium"                                                                                                                                                            
  [576] "Povidone-Iodine"                                                                                                                                                      
  [577] "Prazosin"                                                                                                                                                             
  [578] "Prednimustine"                                                                                                                                                        
  [579] "Prednisolone"                                                                                                                                                         
  [580] "Prednisone"                                                                                                                                                           
  [581] "Primaquine"                                                                                                                                                           
  [582] "Probenecid"                                                                                                                                                           
  [583] "Procarbazine"                                                                                                                                                         
  [584] "Prochlorperazine"                                                                                                                                                     
  [585] "Prochlorperazine_Maleate"                                                                                                                                             
  [586] "Therapeutic_Progestin"                                                                                                                                                
  [587] "Therapeutic_Progesterone"                                                                                                                                             
  [588] "Prolactin"                                                                                                                                                            
  [589] "Promethazine"                                                                                                                                                         
  [590] "Therapeutic_Corynebacterium_Parvum"                                                                                                                                   
  [591] "Propylthiouracil"                                                                                                                                                     
  [592] "Prostaglandin"                                                                                                                                                        
  [593] "Protease_Inhibitor"                                                                                                                                                   
  [594] "Protein_Synthesis_Inhibitor"                                                                                                                                          
  [595] "Protoporphyrin"                                                                                                                                                       
  [596] "Purine"                                                                                                                                                               
  [597] "Puromycin"                                                                                                                                                            
  [598] "Pyrimethamine"                                                                                                                                                        
  [599] "Pyrimidine"                                                                                                                                                           
  [600] "Pyrimidine_Dimer"                                                                                                                                                     
  [601] "Crystalline_Silica_Quartz"                                                                                                                                            
  [602] "Quercetin"                                                                                                                                                            
  [603] "Quinidine"                                                                                                                                                            
  [604] "Quinine"                                                                                                                                                              
  [605] "Quinolone_Antibiotic"                                                                                                                                                 
  [606] "Quinone_Compound"                                                                                                                                                     
  [607] "Radioprotective_Agent"                                                                                                                                                
  [608] "Radiosensitizing_Agent"                                                                                                                                               
  [609] "Radioisotope"                                                                                                                                                         
  [610] "Radon"                                                                                                                                                                
  [611] "Razoxane"                                                                                                                                                             
  [612] "Reagent"                                                                                                                                                              
  [613] "Reserpine"                                                                                                                                                            
  [614] "Retinoic_Acid_Agent"                                                                                                                                                  
  [615] "Rheumatoid_Factor"                                                                                                                                                    
  [616] "Rhodamine"                                                                                                                                                            
  [617] "Ribavirin"                                                                                                                                                            
  [618] "Riboflavin"                                                                                                                                                           
  [619] "Ricin"                                                                                                                                                                
  [620] "Ricin_A_Chain"                                                                                                                                                        
  [621] "Rifampin"                                                                                                                                                             
  [622] "Ribonucleic_Acid"                                                                                                                                                     
  [623] "Messenger_RNA"                                                                                                                                                        
  [624] "Ribosomal_RNA"                                                                                                                                                        
  [625] "Small_Nuclear_RNA"                                                                                                                                                    
  [626] "Transfer_RNA"                                                                                                                                                         
  [627] "Ceftriaxone"                                                                                                                                                          
  [628] "Roxithromycin"                                                                                                                                                        
  [629] "Rutin"                                                                                                                                                                
  [630] "Safflower_Oil"                                                                                                                                                        
  [631] "Saline"                                                                                                                                                               
  [632] "Salt"                                                                                                                                                                 
  [633] "Saponin"                                                                                                                                                              
  [634] "Sizofiran"                                                                                                                                                            
  [635] "Selenium"                                                                                                                                                             
  [636] "Selenomethionine"                                                                                                                                                     
  [637] "Semustine"                                                                                                                                                            
  [638] "Serotonin"                                                                                                                                                            
  [639] "Tobacco_Smoke"                                                                                                                                                        
  [640] "Sodium"                                                                                                                                                               
  [641] "Etidronate_Disodium"                                                                                                                                                  
  [642] "Sodium_Fluoride"                                                                                                                                                      
  [643] "Heparin_Sodium"                                                                                                                                                       
  [644] "Sodium_Salicylate"                                                                                                                                                    
  [645] "Therapeutic_Insulin-Like_Growth_Factor"                                                                                                                               
  [646] "Growth_Hormone_Release_Inhibiting_Factor"                                                                                                                             
  [647] "Therapeutic_Growth_Hormone"                                                                                                                                           
  [648] "Soybean_Oil"                                                                                                                                                          
  [649] "Spiramycin"                                                                                                                                                           
  [650] "Spironolactone"                                                                                                                                                       
  [651] "Stain"                                                                                                                                                                
  [652] "Stanozolol"                                                                                                                                                           
  [653] "Steroid_Compound"                                                                                                                                                     
  [654] "Streptonigrin"                                                                                                                                                        
  [655] "Streptozocin"                                                                                                                                                         
  [656] "Strontium"                                                                                                                                                            
  [657] "Substance-P"                                                                                                                                                          
  [658] "Sucralfate"                                                                                                                                                           
  [659] "Sulfone_Anti-Infective_Agent"                                                                                                                                         
  [660] "Sulindac"                                                                                                                                                             
  [661] "Sunscreen"                                                                                                                                                            
  [662] "Superoxide"                                                                                                                                                           
  [663] "Suramin"                                                                                                                                                              
  [664] "Talc"                                                                                                                                                                 
  [665] "Tamoxifen"                                                                                                                                                            
  [666] "Tc_99m_Sulfur_Colloid"                                                                                                                                                
  [667] "Teniposide"                                                                                                                                                           
  [668] "Tenuazonic_Acid"                                                                                                                                                      
  [669] "Teratogen"                                                                                                                                                            
  [670] "Terpene_Compound"                                                                                                                                                     
  [671] "Testolactone_Therapeutic"                                                                                                                                             
  [672] "Therapeutic_Testosterone"                                                                                                                                             
  [673] "Testosterone_Propionate"                                                                                                                                              
  [674] "Tetrachlorodibenzodioxin"                                                                                                                                             
  [675] "Tetracycline"                                                                                                                                                         
  [676] "Tetradecanoylphorbol_Acetate"                                                                                                                                         
  [677] "Dronabinol"                                                                                                                                                           
  [678] "Tetrahydrouridine"                                                                                                                                                    
  [679] "Thalicarpine"                                                                                                                                                         
  [680] "Thalidomide"                                                                                                                                                          
  [681] "Thebaine"                                                                                                                                                             
  [682] "Theophylline"                                                                                                                                                         
  [683] "Thiabendazole"                                                                                                                                                        
  [684] "Thiamine"                                                                                                                                                             
  [685] "Thiotepa"                                                                                                                                                             
  [686] "Thioguanine"                                                                                                                                                          
  [687] "Thioinosine"                                                                                                                                                          
  [688] "Recombinant_Human_Thrombopoietin"                                                                                                                                     
  [689] "Thromboxane"                                                                                                                                                          
  [690] "Thymidine"                                                                                                                                                            
  [691] "Thymine"                                                                                                                                                              
  [692] "Thymopoietin"                                                                                                                                                         
  [693] "Recombinant_Thymosin"                                                                                                                                                 
  [694] "Therapeutic_Thyroglobulin"                                                                                                                                            
  [695] "Antithyroid_Agent"                                                                                                                                                    
  [696] "Thyroid_Hormone"                                                                                                                                                      
  [697] "Recombinant_Thyroid-Stimulating_Hormone"                                                                                                                              
  [698] "Therapeutic_Levothyroxine"                                                                                                                                            
  [699] "Ticarcillin"                                                                                                                                                          
  [700] "Tinidazole"                                                                                                                                                           
  [701] "Tobacco"                                                                                                                                                              
  [702] "Smokeless_Tobacco"                                                                                                                                                    
  [703] "Tobramycin"                                                                                                                                                           
  [704] "Toxin"                                                                                                                                                                
  [705] "Chromomycin_A3"                                                                                                                                                       
  [706] "Trace_Element"                                                                                                                                                        
  [707] "Therapeutic_Transforming_Growth_Factor-Alpha"                                                                                                                         
  [708] "Therapeutic_Transforming_Growth_Factor-Beta"                                                                                                                          
  [709] "Therapeutic_Transforming_Growth_Factor"                                                                                                                               
  [710] "Vitamin_A_Acid"                                                                                                                                                       
  [711] "Triamcinolone"                                                                                                                                                        
  [712] "Triazene_Compound"                                                                                                                                                    
  [713] "Triaziquone"                                                                                                                                                          
  [714] "Trifluoperazine"                                                                                                                                                      
  [715] "Trifluridine"                                                                                                                                                         
  [716] "Triglycerides"                                                                                                                                                        
  [717] "Therapeutic_Triiodothyronine"                                                                                                                                         
  [718] "Trimethoprim"                                                                                                                                                         
  [719] "Trimethoprim-Sulfamethoxazole"                                                                                                                                        
  [720] "Trypan_Blue"                                                                                                                                                          
  [721] "Tubercidin"                                                                                                                                                           
  [722] "Tumor_Antigen"                                                                                                                                                        
  [723] "Therapeutic_Tumor_Necrosis_Factor-Alpha"                                                                                                                              
  [724] "Tumor_Promoter"                                                                                                                                                       
  [725] "Tyrosine"                                                                                                                                                             
  [726] "Coenzyme-Q"                                                                                                                                                           
  [727] "Uracil"                                                                                                                                                               
  [728] "Uracil_Mustard"                                                                                                                                                       
  [729] "Urea_Nitrogen"                                                                                                                                                        
  [730] "Urethan"                                                                                                                                                              
  [731] "Uricosuric_Agent"                                                                                                                                                     
  [732] "Uridine"                                                                                                                                                              
  [733] "Vaccine"                                                                                                                                                              
  [734] "Mould_Element"                                                                                                                                                        
  [735] "Vancomycin"                                                                                                                                                           
  [736] "Therapeutic_Vasopressin"                                                                                                                                              
  [737] "Drug_Vehicle"                                                                                                                                                         
  [738] "Verapamil"                                                                                                                                                            
  [739] "Vidarabine"                                                                                                                                                           
  [740] "Vinblastine"                                                                                                                                                          
  [741] "Vinblastine_Sulfate"                                                                                                                                                  
  [742] "Vinca_Alkaloid_Compound"                                                                                                                                              
  [743] "Vincristine"                                                                                                                                                          
  [744] "Vindesine"                                                                                                                                                            
  [745] "Vindesine_Sulfate"                                                                                                                                                    
  [746] "Vinyl_Chloride"                                                                                                                                                       
  [747] "Virginiamycin"                                                                                                                                                        
  [748] "Vitamin_A"                                                                                                                                                            
  [749] "Vitamin_B12"                                                                                                                                                          
  [750] "Vitamin_B_Complex"                                                                                                                                                    
  [751] "Vitamin_D"                                                                                                                                                            
  [752] "Vitamin_E"                                                                                                                                                            
  [753] "Vitamin_K"                                                                                                                                                            
  [754] "Vitamin"                                                                                                                                                              
  [755] "Warfarin"                                                                                                                                                             
  [756] "Pentosan_Polysulfate_Sodium"                                                                                                                                          
  [757] "Zidovudine"                                                                                                                                                           
  [758] "Zinc"                                                                                                                                                                 
  [759] "Zinc_Oxide"                                                                                                                                                           
  [760] "Anaxirone"                                                                                                                                                            
  [761] "Dibenzo_a_h_Anthracene"                                                                                                                                               
  [762] "Tesmilifene_Hydrochloride"                                                                                                                                            
  [763] "AZP"                                                                                                                                                                  
  [764] "Tauromustine"                                                                                                                                                         
  [765] "Carmofur"                                                                                                                                                             
  [766] "Edelfosine"                                                                                                                                                           
  [767] "_10-Deacetyltaxol"                                                                                                                                                    
  [768] "Edatrexate"                                                                                                                                                           
  [769] "_12-Hydroxy-5_8_10_14-Eicosatetraenoic_Acid"                                                                                                                          
  [770] "Hydroxyprogesterone_Caproate"                                                                                                                                         
  [771] "Gemcitabine"                                                                                                                                                          
  [772] "_2_2_2_Trichlorotriethylamine"                                                                                                                                        
  [773] "SarCNU"                                                                                                                                                               
  [774] "Fludeoxyglucose_F_18"                                                                                                                                                 
  [775] "_2-Methoxyestradiol"                                                                                                                                                  
  [776] "Dichloromethotrexate"                                                                                                                                                 
  [777] "Cordycepin_Triphosphate"                                                                                                                                              
  [778] "Dezaguanine"                                                                                                                                                          
  [779] "Droloxifene"                                                                                                                                                          
  [780] "Meta-Iodobenzylguanidine"                                                                                                                                             
  [781] "_4_Iodo-4_Deoxydoxorubicin"                                                                                                                                           
  [782] "Deoxydoxorubicin"                                                                                                                                                     
  [783] "Alendronate_Sodium"                                                                                                                                                   
  [784] "Formestane"                                                                                                                                                           
  [785] "_4-Hydroxy-Tamoxifen"                                                                                                                                                 
  [786] "Ipomeanol"                                                                                                                                                            
  [787] "_4-Nitroestrone_3-Methyl_Ether"                                                                                                                                       
  [788] "Doxifluridine"                                                                                                                                                        
  [789] "Lometrexol"                                                                                                                                                           
  [790] "Dihydro-5-Azacytidine"                                                                                                                                                
  [791] "Decitabine"                                                                                                                                                           
  [792] "Chloroquinoxaline_Sulfonamide"                                                                                                                                        
  [793] "Acarbose"                                                                                                                                                             
  [794] "Aceglatone"                                                                                                                                                           
  [795] "Acitretin"                                                                                                                                                            
  [796] "Acivicin"                                                                                                                                                             
  [797] "Aclacinomycin_Antibiotic"                                                                                                                                             
  [798] "Acodazole"                                                                                                                                                            
  [799] "Recombinant_Activin"                                                                                                                                                  
  [800] "Corynebacterium_Granulosum_P40"                                                                                                                                       
  [801] "Recombinant_ATL_Derived_Factor"                                                                                                                                       
  [802] "Monobenzone"                                                                                                                                                          
  [803] "AL721"                                                                                                                                                                
  [804] "L-Alanosine"                                                                                                                                                          
  [805] "Alizapride"                                                                                                                                                           
  [806] "Allocolchicine"                                                                                                                                                       
  [807] "Alpha-Linolenic_Acid"                                                                                                                                                 
  [808] "Metyrosine"                                                                                                                                                           
  [809] "Amonafide"                                                                                                                                                            
  [810] "Recombinant_Amphiregulin"                                                                                                                                             
  [811] "Atvogen"                                                                                                                                                              
  [812] "Recombinant_Angiogenin"                                                                                                                                               
  [813] "Ansamycin_Antineoplastic_Antibiotic"                                                                                                                                  
  [814] "Antineoplaston_A10"                                                                                                                                                   
  [815] "Arsenic_Trioxide"                                                                                                                                                     
  [816] "Ossirene"                                                                                                                                                             
  [817] "Azapicyl"                                                                                                                                                             
  [818] "Azauridine_Triacetate"                                                                                                                                                
  [819] "Ethylenimine"                                                                                                                                                         
  [820] "Nafazatrom"                                                                                                                                                           
  [821] "Beauvericin"                                                                                                                                                          
  [822] "Benzodiazepine"                                                                                                                                                       
  [823] "Benznidazole"                                                                                                                                                         
  [824] "Verteporfin"                                                                                                                                                          
  [825] "Ubenimex"                                                                                                                                                             
  [826] "Beta_Carotene"                                                                                                                                                        
  [827] "Glucuronidase_Inhibitor"                                                                                                                                              
  [828] "Klebsiella_pneumoniae_Glycoprotein"                                                                                                                                   
  [829] "Bisantrene"                                                                                                                                                           
  [830] "Bismuth_Subsalicylate"                                                                                                                                                
  [831] "Batanopride"                                                                                                                                                          
  [832] "Emitefur"                                                                                                                                                             
  [833] "Amoxicillin-Clavulanate_Potassium"                                                                                                                                    
  [834] "Bropirimine"                                                                                                                                                          
  [835] "Bruceantin"                                                                                                                                                           
  [836] "Bryostatin-1"                                                                                                                                                         
  [837] "Budesonide"                                                                                                                                                           
  [838] "Butein"                                                                                                                                                               
  [839] "Buthionine_Sulfoximine"                                                                                                                                               
  [840] "Butocin"                                                                                                                                                              
  [841] "Piritrexim"                                                                                                                                                           
  [842] "Cactinomycin"                                                                                                                                                         
  [843] "Citrated_Caffeine"                                                                                                                                                    
  [844] "Heparin_Calcium"                                                                                                                                                      
  [845] "Calicheamicin_Gamma_1I"                                                                                                                                               
  [846] "Canola_Oil"                                                                                                                                                           
  [847] "Caracemide"                                                                                                                                                           
  [848] "Carbogen"                                                                                                                                                             
  [849] "Carbovir"                                                                                                                                                             
  [850] "Carzinophilin"                                                                                                                                                        
  [851] "Cefepime"                                                                                                                                                             
  [852] "Cetirizine"                                                                                                                                                           
  [853] "CGP-6809"                                                                                                                                                             
  [854] "Fadrozole_Hydrochloride"                                                                                                                                              
  [855] "Chamomile"                                                                                                                                                            
  [856] "Chaparrinone"                                                                                                                                                         
  [857] "Chlornaphazine"                                                                                                                                                       
  [858] "Chloroaluminum_Phthalocyanine"                                                                                                                                        
  [859] "Chlorozotocin"                                                                                                                                                        
  [860] "CI-921"                                                                                                                                                               
  [861] "Cilostazol"                                                                                                                                                           
  [862] "CL_246738"                                                                                                                                                            
  [863] "Zeniplatin"                                                                                                                                                           
  [864] "Clarithromycin"                                                                                                                                                       
  [865] "OGX-011"                                                                                                                                                              
  [866] "Copovithane"                                                                                                                                                          
  [867] "Cordycepin"                                                                                                                                                           
  [868] "Cortisone_Acetate"                                                                                                                                                    
  [869] "Cyproterone_Acetate"                                                                                                                                                  
  [870] "Daidzein"                                                                                                                                                             
  [871] "Daunorubicin-DNA_Complex"                                                                                                                                             
  [872] "Duborimycin"                                                                                                                                                          
  [873] "Defensins"                                                                                                                                                            
  [874] "Defibrotide"                                                                                                                                                          
  [875] "Desmethylmisonidazole"                                                                                                                                                
  [876] "Detorubicin"                                                                                                                                                          
  [877] "Dexamethasone_Acetate"                                                                                                                                                
  [878] "Anguidine"                                                                                                                                                            
  [879] "Dibenzo_a_l_Pyrene"                                                                                                                                                   
  [880] "Iproplatin"                                                                                                                                                           
  [881] "Porfimer_Sodium"                                                                                                                                                      
  [882] "_1_1-Dimethylhydrazine"                                                                                                                                               
  [883] "Dimethylbusulfan"                                                                                                                                                     
  [884] "Dinoprost_Tromethamine"                                                                                                                                               
  [885] "Doxorubicin-DNA_Complex"                                                                                                                                              
  [886] "Dromostanolone"                                                                                                                                                       
  [887] "Dromostanolone_Propionate"                                                                                                                                            
  [888] "Brequinar_Sodium"                                                                                                                                                     
  [889] "Dynemicin_A"                                                                                                                                                          
  [890] "Elsamitrucin"                                                                                                                                                         
  [891] "Eutectic_Mixture_of_Local_Anesthetics"                                                                                                                                
  [892] "Enocitabine"                                                                                                                                                          
  [893] "Staphylococcal_Enterotoxin_A"                                                                                                                                         
  [894] "Staphylococcal_Enterotoxin_B"                                                                                                                                         
  [895] "Staphylococcal_Enterotoxin_C"                                                                                                                                         
  [896] "Toxic_Shock_Syndrome_Toxin-1"                                                                                                                                         
  [897] "EO9"                                                                                                                                                                  
  [898] "Epigallocatechin_Gallate"                                                                                                                                             
  [899] "Epitiostanol"                                                                                                                                                         
  [900] "Estradiol_Valerate"                                                                                                                                                   
  [901] "Estrone-Sulfate"                                                                                                                                                      
  [902] "Etanidazole"                                                                                                                                                          
  [903] "Etoposide_Phosphate"                                                                                                                                                  
  [904] "Fludarabine"                                                                                                                                                          
  [905] "Pyrimethamine-Sulfadoxine"                                                                                                                                            
  [906] "Fazarabine"                                                                                                                                                           
  [907] "Exemestane"                                                                                                                                                           
  [908] "Fenretinide"                                                                                                                                                          
  [909] "Finasteride"                                                                                                                                                          
  [910] "Cefixime"                                                                                                                                                             
  [911] "Flavone_Acetic_Acid"                                                                                                                                                  
  [912] "Fludarabine_Phosphate"                                                                                                                                                
  [913] "Fludrocortisone"                                                                                                                                                      
  [914] "Fluosol-DA"                                                                                                                                                           
  [915] "Diethylstilbestrol_Diphosphate"                                                                                                                                       
  [916] "Fotemustine"                                                                                                                                                          
  [917] "Fumonisin_B1"                                                                                                                                                         
  [918] "Gabapentin"                                                                                                                                                           
  [919] "Gallium_Nitrate"                                                                                                                                                      
  [920] "Ganglioside_GD2"                                                                                                                                                      
  [921] "Gastrin_Releasing_Peptide_Therapeutic"                                                                                                                                
  [922] "Geldanamycin"                                                                                                                                                         
  [923] "Genistein"                                                                                                                                                            
  [924] "Glaucarubolone"                                                                                                                                                       
  [925] "Glutamic_Acid"                                                                                                                                                        
  [926] "Glycosylphosphatidylinositol"                                                                                                                                         
  [927] "Glycyrrhizin"                                                                                                                                                         
  [928] "Gossypol_Acetic_Acid"                                                                                                                                                 
  [929] "Ondansetron"                                                                                                                                                          
  [930] "Halofuginone"                                                                                                                                                         
  [931] "HC-Toxin"                                                                                                                                                             
  [932] "Therapeutic_Hepatocyte_Growth_Factor"                                                                                                                                 
  [933] "Hepsulfam"                                                                                                                                                            
  [934] "Herbimycin"                                                                                                                                                           
  [935] "Hexamethylene_Bisacetamide"                                                                                                                                           
  [936] "Haemophilus_Influenzae_B_Vaccine"                                                                                                                                     
  [937] "Homoharringtonine"                                                                                                                                                    
  [938] "Leflunomide"                                                                                                                                                          
  [939] "Hydrazine_Sulfate"                                                                                                                                                    
  [940] "Hydroxyl_Radical"                                                                                                                                                     
  [941] "Tropisetron"                                                                                                                                                          
  [942] "IMREG-1"                                                                                                                                                              
  [943] "ImuVert"                                                                                                                                                              
  [944] "Indicine-N-Oxide"                                                                                                                                                     
  [945] "Indole-3-Carbinol"                                                                                                                                                    
  [946] "Inosine_Dialdehyde"                                                                                                                                                   
  [947] "Iopromide"                                                                                                                                                            
  [948] "Itraconazole"                                                                                                                                                         
  [949] "Keyhole_Limpet_Hemocyanin"                                                                                                                                            
  [950] "KW-2149"                                                                                                                                                              
  [951] "Carboxyamidotriazole"                                                                                                                                                 
  [952] "Lavendustin_A"                                                                                                                                                        
  [953] "Therapeutic_Leukoregulin"                                                                                                                                             
  [954] "Nafarelin"                                                                                                                                                            
  [955] "Lignans"                                                                                                                                                              
  [956] "Lonidamine"                                                                                                                                                           
  [957] "Therapeutic_Interleukin-16"                                                                                                                                           
  [958] "Therapeutic_Lymphotactin"                                                                                                                                             
  [959] "Maalox"                                                                                                                                                               
  [960] "Mafosfamide"                                                                                                                                                          
  [961] "Mannose-Binding_Lectin"                                                                                                                                               
  [962] "Marcellomycin"                                                                                                                                                        
  [963] "Dolasetron_Mesylate"                                                                                                                                                  
  [964] "Carbendazim"                                                                                                                                                          
  [965] "Medroxyprogesterone_17-Acetate"                                                                                                                                       
  [966] "Megestrol_Acetate"                                                                                                                                                    
  [967] "GRO1_Protein_Recombinant"                                                                                                                                             
  [968] "Mepitiostane"                                                                                                                                                         
  [969] "Methanol_Extraction_Residue_of_BCG"                                                                                                                                   
  [970] "Meropenem"                                                                                                                                                            
  [971] "Metoprine"                                                                                                                                                            
  [972] "Methylene_Dimethane_Sulfonate"                                                                                                                                        
  [973] "N-Methylformamide"                                                                                                                                                    
  [974] "Mitomycin_A"                                                                                                                                                          
  [975] "_2-Ethylhydrazide"                                                                                                                                                    
  [976] "Mitozolomide"                                                                                                                                                         
  [977] "Cystemustine"                                                                                                                                                         
  [978] "N_1_N_11_bis_ethyl_norspermine"                                                                                                                                       
  [979] "Carboxyphenyl_Retinamide"                                                                                                                                             
  [980] "Miltefosine"                                                                                                                                                          
  [981] "Nabilone"                                                                                                                                                             
  [982] "Nandrolone_Decanoate"                                                                                                                                                 
  [983] "Nilutamide"                                                                                                                                                           
  [984] "Novembichin"                                                                                                                                                          
  [985] "Olive_Oil"                                                                                                                                                            
  [986] "Olsalazine"                                                                                                                                                           
  [987] "Oltipraz"                                                                                                                                                             
  [988] "NG-Monomethyl-L-Arginine"                                                                                                                                             
  [989] "Papillomavirus_Type_16_Protein-E7"                                                                                                                                    
  [990] "Therapeutic_Oncostatin_M"                                                                                                                                             
  [991] "Oxaliplatin"                                                                                                                                                          
  [992] "Piroxantrone"                                                                                                                                                         
  [993] "Ranpirnase"                                                                                                                                                           
  [994] "Pancratistatin"                                                                                                                                                       
  [995] "Therapeutic_Parathyroid_Hormone-Related_Protein"                                                                                                                      
  [996] "PCNU"                                                                                                                                                                 
  [997] "Penberol"                                                                                                                                                             
  [998] "Penclomedine"                                                                                                                                                         
  [999] "Pentamethylmelamine"                                                                                                                                                  
 [1000] "Phenesterin"                                                                                                                                                          
 [1001] "Phenol"                                                                                                                                                               
 [1002] "Phosphatidylinositol_4_5-bisphosphate"                                                                                                                                
 [1003] "Foscarnet"                                                                                                                                                            
 [1004] "Phytoestrogen"                                                                                                                                                        
 [1005] "Piceatannol"                                                                                                                                                          
 [1006] "Pimonidazole"                                                                                                                                                         
 [1007] "Pirarubicin"                                                                                                                                                          
 [1008] "Poly_ICLC"                                                                                                                                                            
 [1009] "Polyestradiol_Phosphate"                                                                                                                                              
 [1010] "Pegaspargase"                                                                                                                                                         
 [1011] "Polysialic_Acid"                                                                                                                                                      
 [1012] "Prednisolone_Acetate"                                                                                                                                                 
 [1013] "Therapeutic_Prothymosin_Alpha"                                                                                                                                        
 [1014] "Polysaccharide-K"                                                                                                                                                     
 [1015] "Tectorigenin"                                                                                                                                                         
 [1016] "Pteropterin"                                                                                                                                                          
 [1017] "Pyrazine_Diazohydroxide"                                                                                                                                              
 [1018] "Pyrazofurin"                                                                                                                                                          
 [1019] "Pyrene"                                                                                                                                                               
 [1020] "Cisapride"                                                                                                                                                            
 [1021] "Therapeutic_RANTES"                                                                                                                                                   
 [1022] "Sirolimus"                                                                                                                                                            
 [1023] "Rebeccamycin"                                                                                                                                                         
 [1024] "Resiniferatoxin"                                                                                                                                                      
 [1025] "Resveratrol"                                                                                                                                                          
 [1026] "Retinyl_Acetate"                                                                                                                                                      
 [1027] "Retinyl_Palmitate"                                                                                                                                                    
 [1028] "Rhizoxin"                                                                                                                                                             
 [1029] "Ketorolac"                                                                                                                                                            
 [1030] "Sm_153_Lexidronam_Pentasodium"                                                                                                                                        
 [1031] "Saperconazole"                                                                                                                                                        
 [1032] "SC-48334"                                                                                                                                                             
 [1033] "Selenocysteine"                                                                                                                                                       
 [1034] "Atamestane"                                                                                                                                                           
 [1035] "Shiga_Toxin"                                                                                                                                                          
 [1036] "Sialyl_Tn_Antigen"                                                                                                                                                    
 [1037] "Simalikalactone_D"                                                                                                                                                    
 [1038] "Sodium_Molybdate"                                                                                                                                                     
 [1039] "Sodium_Selenate"                                                                                                                                                      
 [1040] "Sodium_Thiosulfate"                                                                                                                                                   
 [1041] "Spherex"                                                                                                                                                              
 [1042] "Spirogermanium"                                                                                                                                                       
 [1043] "Spiromustine"                                                                                                                                                         
 [1044] "Spiroplatin"                                                                                                                                                          
 [1045] "ST_638"                                                                                                                                                               
 [1046] "Staphage_Lysate"                                                                                                                                                      
 [1047] "Staurosporine"                                                                                                                                                        
 [1048] "Strontium_Chloride_Sr_89"                                                                                                                                             
 [1049] "Sulindac_Sulfone"                                                                                                                                                     
 [1050] "Sumatriptan"                                                                                                                                                          
 [1051] "Sunflower_Oil"                                                                                                                                                        
 [1052] "Tazobactam"                                                                                                                                                           
 [1053] "Tc_99m_Dextran"                                                                                                                                                       
 [1054] "Temozolomide"                                                                                                                                                         
 [1055] "Terephthalamidine"                                                                                                                                                    
 [1056] "Testosterone_Cypionate"                                                                                                                                               
 [1057] "Testosterone_Enanthate"                                                                                                                                               
 [1058] "Testosterone_Isobutyrate"                                                                                                                                             
 [1059] "Testosterone_Undecanoate"                                                                                                                                             
 [1060] "Ormaplatin"                                                                                                                                                           
 [1061] "Thiamiprine"                                                                                                                                                          
 [1062] "Thiocolchicine"                                                                                                                                                       
 [1063] "Thymalfasin"                                                                                                                                                          
 [1064] "Tiazofurin"                                                                                                                                                           
 [1065] "Tin_Ethyl_Etiopurpurin"                                                                                                                                               
 [1066] "Toremifene"                                                                                                                                                           
 [1067] "Treosulfan"                                                                                                                                                           
 [1068] "Triazinate"                                                                                                                                                           
 [1069] "Tributyl_Phosphate"                                                                                                                                                   
 [1070] "Tributyrin"                                                                                                                                                           
 [1071] "Trichostatin_A"                                                                                                                                                       
 [1072] "Triciribine_Phosphate"                                                                                                                                                
 [1073] "Trilostane"                                                                                                                                                           
 [1074] "Trimethylcolchicinic_Acid"                                                                                                                                            
 [1075] "Trimetrexate_Glucuronate"                                                                                                                                             
 [1076] "Trioxifene"                                                                                                                                                           
 [1077] "Triptorelin"                                                                                                                                                          
 [1078] "Trofosfamide"                                                                                                                                                         
 [1079] "TAG-72_Antigen"                                                                                                                                                       
 [1080] "Adozelesin"                                                                                                                                                           
 [1081] "_7-Hydroxystaurosporine"                                                                                                                                              
 [1082] "Therapeutic_Vascular_Endothelial_Growth_Factor"                                                                                                                       
 [1083] "Vindoline"                                                                                                                                                            
 [1084] "Vinepidine"                                                                                                                                                           
 [1085] "Vinorelbine"                                                                                                                                                          
 [1086] "Vinzolidine"                                                                                                                                                          
 [1087] "Wortmannin"                                                                                                                                                           
 [1088] "Venlafaxine"                                                                                                                                                          
 [1089] "Pingyangmycin"                                                                                                                                                        
 [1090] "Zinc_Sulfate"                                                                                                                                                         
 [1091] "Biohazard"                                                                                                                                                            
 [1092] "Carboplatin"                                                                                                                                                          
 [1093] "Therapeutic_Cytokine"                                                                                                                                                 
 [1094] "Dextran_Sulfate_Sodium"                                                                                                                                               
 [1095] "Endothelin-1"                                                                                                                                                         
 [1096] "Therapeutic_Transforming_Growth_Factor-Beta_2"                                                                                                                        
 [1097] "Recombinant_Granulocyte_Colony_Stimulating_Factor"                                                                                                                    
 [1098] "Therapeutic_Granulocyte-Macrophage_Colony-Stimulating_Factor"                                                                                                         
 [1099] "Therapeutic_Interleukin-8"                                                                                                                                            
 [1100] "Recombinant_Macrophage_Colony-Stimulating_Factor"                                                                                                                     
 [1101] "Antisense_Agent"                                                                                                                                                      
 [1102] "Ribozyme"                                                                                                                                                             
 [1103] "Therapeutic_Transforming_Growth_Factor-Beta_1"                                                                                                                        
 [1104] "Thymopentin"                                                                                                                                                          
 [1105] "Virginiamycin_M1"                                                                                                                                                     
 [1106] "Virginiamycin_S1"                                                                                                                                                     
 [1107] "_8-Oxo-2_Deoxyguanosine"                                                                                                                                              
 [1108] "TNP-470"                                                                                                                                                              
 [1109] "Disulfonated_Aluminum_Phthalocyanine"                                                                                                                                 
 [1110] "Dolastatin_10"                                                                                                                                                        
 [1111] "Esperamicin_A1"                                                                                                                                                       
 [1112] "Therapeutic_I309"                                                                                                                                                     
 [1113] "Therapeutic_Interleukin-11"                                                                                                                                           
 [1114] "PEG-interleukin-2"                                                                                                                                                    
 [1115] "Erbstatin_Analog"                                                                                                                                                     
 [1116] "O_6_Benzylguanine"                                                                                                                                                    
 [1117] "Recombinant_Pleiotrophin"                                                                                                                                             
 [1118] "Poly_RGD"                                                                                                                                                             
 [1119] "Therapeutic_Fibroblast_Growth_Factor_4"                                                                                                                               
 [1120] "Ro_31-8220"                                                                                                                                                           
 [1121] "Tacrolimus"                                                                                                                                                           
 [1122] "Generic_Drug"                                                                                                                                                         
 [1123] "Misoprostol"                                                                                                                                                          
 [1124] "Trimetrexate"                                                                                                                                                         
 [1125] "Aflatoxin_B1"                                                                                                                                                         
 [1126] "_6-Hydroxydopamine"                                                                                                                                                   
 [1127] "Bupropion"                                                                                                                                                            
 [1128] "Lithium_Carbonate"                                                                                                                                                    
 [1129] "Leuprolide"                                                                                                                                                           
 [1130] "Therapeutic_Interleukin_10"                                                                                                                                           
 [1131] "Monoclonal_Antibody_OKT3"                                                                                                                                             
 [1132] "Lipooxygenase_Inhibitor"                                                                                                                                              
 [1133] "Cyclooxygenase_Inhibitor"                                                                                                                                             
 [1134] "Therapeutic_Interleukin-9"                                                                                                                                            
 [1135] "HIV_Vaccine"                                                                                                                                                          
 [1136] "Doxorubicin_Hydrochloride"                                                                                                                                            
 [1137] "Antiplatelet_Agent"                                                                                                                                                   
 [1138] "BCG"                                                                                                                                                                  
 [1139] "Cloning_Vector"                                                                                                                                                       
 [1140] "Deoxythymidine"                                                                                                                                                       
 [1141] "Epipodophyllotoxin_Compound"                                                                                                                                          
 [1142] "Etidronate"                                                                                                                                                           
 [1143] "Dexrazoxane"                                                                                                                                                          
 [1144] "Vitamin_B6"                                                                                                                                                           
 [1145] "Aminothiadiazole"                                                                                                                                                     
 [1146] "Cladribine"                                                                                                                                                           
 [1147] "Cevimeline"                                                                                                                                                           
 [1148] "Didox"                                                                                                                                                                
 [1149] "BW_A773U"                                                                                                                                                             
 [1150] "Valrubicin"                                                                                                                                                           
 [1151] "Tyrphostin_A51"                                                                                                                                                       
 [1152] "Ametantrone"                                                                                                                                                          
 [1153] "Aminosyn"                                                                                                                                                             
 [1154] "Pivaloyloxymethylbutyrate"                                                                                                                                            
 [1155] "Pamidronate_Disodium"                                                                                                                                                 
 [1156] "Asaley"                                                                                                                                                               
 [1157] "Azimexon"                                                                                                                                                             
 [1158] "Bestrabucil"                                                                                                                                                          
 [1159] "Recombinant_Inhibin_B"                                                                                                                                                
 [1160] "Beta-Thioguanine_Deoxyriboside"                                                                                                                                       
 [1161] "Bismuth_Subcitrate"                                                                                                                                                   
 [1162] "Therapeutic_Brain-Derived_Growth_Factors"                                                                                                                             
 [1163] "Granisetron"                                                                                                                                                          
 [1164] "Crisnatol_Mesylate"                                                                                                                                                   
 [1165] "Calcium_Citrate"                                                                                                                                                      
 [1166] "Carbetimer"                                                                                                                                                           
 [1167] "Mivobulin_Isethionate"                                                                                                                                                
 [1168] "Therapeutic_CTAP_III"                                                                                                                                                 
 [1169] "Cyclopentenyl_Cytosine"                                                                                                                                               
 [1170] "Cytembena"                                                                                                                                                            
 [1171] "Depudecin"                                                                                                                                                            
 [1172] "Dexamethasone_Sodium_Phosphate"                                                                                                                                       
 [1173] "Diaziquone"                                                                                                                                                           
 [1174] "Didemnin_B"                                                                                                                                                           
 [1175] "Dimesna"                                                                                                                                                              
 [1176] "Doxorubicin-HPMA_Conjugate"                                                                                                                                           
 [1177] "Elliptinium"                                                                                                                                                          
 [1178] "Therapeutic_ENA-78"                                                                                                                                                   
 [1179] "Recombinant_Fibroblast_Growth_Factor_6"                                                                                                                               
 [1180] "Recombinant_Fibroblast_Growth_Factor_5"                                                                                                                               
 [1181] "Fosquidone"                                                                                                                                                           
 [1182] "Fostriecin"                                                                                                                                                           
 [1183] "Girodazole"                                                                                                                                                           
 [1184] "Goserelin"                                                                                                                                                            
 [1185] "Guanidinium"                                                                                                                                                          
 [1186] "Halichondrin_B"                                                                                                                                                       
 [1187] "Hematoporphyrin_Derivative"                                                                                                                                           
 [1188] "Antimoniotungstate"                                                                                                                                                   
 [1189] "Fulvestrant"                                                                                                                                                          
 [1190] "Therapeutic_Interleukin-12"                                                                                                                                           
 [1191] "Irinotecan"                                                                                                                                                           
 [1192] "K_252a"                                                                                                                                                               
 [1193] "Liposomal-Cisplatin_Analogue"                                                                                                                                         
 [1194] "Therapeutic_Leukemia_Inhibitory_Factor"                                                                                                                               
 [1195] "Levonantradol"                                                                                                                                                        
 [1196] "Isosulfan_Blue"                                                                                                                                                       
 [1197] "MAGE-1_Antigen"                                                                                                                                                       
 [1198] "Maxzide"                                                                                                                                                              
 [1199] "Menogaril"                                                                                                                                                            
 [1200] "Merbarone"                                                                                                                                                            
 [1201] "Therapeutic_Macrophage_Inflammatory_Protein-1_Alpha"                                                                                                                  
 [1202] "Mitomycin_B"                                                                                                                                                          
 [1203] "Therapeutic_Monocyte_Chemoattractant_Protein_1"                                                                                                                       
 [1204] "Muramyl_Tripeptide_Phosphatidylethanolamine"                                                                                                                          
 [1205] "Vinorelbine_Ditartrate"                                                                                                                                               
 [1206] "Therapeutic_Neurotrophins"                                                                                                                                            
 [1207] "Human_Papillomavirus_Type_16_Protein_E6"                                                                                                                              
 [1208] "N-Phosphonacetyl-L-aspartate"                                                                                                                                         
 [1209] "Peplomycin"                                                                                                                                                           
 [1210] "Peplomycin_Sulfate"                                                                                                                                                   
 [1211] "Piperazinedione"                                                                                                                                                      
 [1212] "Prednisolone_Sodium_Phosphate"                                                                                                                                        
 [1213] "Prednisolone_Sodium_Succinate"                                                                                                                                        
 [1214] "Protein_Kinase_Inhibitor"                                                                                                                                             
 [1215] "Valspodar"                                                                                                                                                            
 [1216] "Idoxifene"                                                                                                                                                            
 [1217] "RG_13022"                                                                                                                                                             
 [1218] "Rifabutin"                                                                                                                                                            
 [1219] "Carbenicillin_Indanyl_Sodium"                                                                                                                                         
 [1220] "Therapeutic_Stem_Cell_Factor"                                                                                                                                         
 [1221] "Paclitaxel"                                                                                                                                                           
 [1222] "Teicoplanin"                                                                                                                                                          
 [1223] "Topotecan"                                                                                                                                                            
 [1224] "Trioxifene_Mesylate"                                                                                                                                                  
 [1225] "Vesnarinone"                                                                                                                                                          
 [1226] "Yoshi-864"                                                                                                                                                            
 [1227] "Goserelin_Acetate"                                                                                                                                                    
 [1228] "Clodronate_Disodium"                                                                                                                                                  
 [1229] "Tc_99m_Sestamibi"                                                                                                                                                     
 [1230] "Photosensitizing_Agent"                                                                                                                                               
 [1231] "Oxygen_Radicals"                                                                                                                                                      
 [1232] "Perflubron"                                                                                                                                                           
 [1233] "Perfosfamide"                                                                                                                                                         
 [1234] "Sulforaphane"                                                                                                                                                         
 [1235] "Eucerin"                                                                                                                                                              
 [1236] "Recombinant_Heregulin"                                                                                                                                                
 [1237] "Rogletimide"                                                                                                                                                          
 [1238] "Stavudine"                                                                                                                                                            
 [1239] "Vapreotide"                                                                                                                                                           
 [1240] "Cephalomannine"                                                                                                                                                       
 [1241] "Imiquimod"                                                                                                                                                            
 [1242] "Sulofenur"                                                                                                                                                            
 [1243] "Liarozole"                                                                                                                                                            
 [1244] "Lobaplatin"                                                                                                                                                           
 [1245] "RSR-13"                                                                                                                                                               
 [1246] "Baccatin_III"                                                                                                                                                         
 [1247] "Therapeutic_CD40-Ligand"                                                                                                                                              
 [1248] "Troxacitabine"                                                                                                                                                        
 [1249] "Dolastatin_15"                                                                                                                                                        
 [1250] "_4-Phenylbutyrate"                                                                                                                                                    
 [1251] "Carzelesin"                                                                                                                                                           
 [1252] "Morpholinodoxorubicin"                                                                                                                                                
 [1253] "Organochlorine_Compound"                                                                                                                                              
 [1254] "Folate"                                                                                                                                                               
 [1255] "Hyaluronate"                                                                                                                                                          
 [1256] "Radiopharmaceutical_Compound"                                                                                                                                         
 [1257] "Barium_Enema"                                                                                                                                                         
 [1258] "Nafoxidine_Hydrochloride"                                                                                                                                             
 [1259] "Thorotrast"                                                                                                                                                           
 [1260] "Platinum_Compound"                                                                                                                                                    
 [1261] "Oligonucleotide_Primers"                                                                                                                                              
 [1262] "Enoxaparin"                                                                                                                                                           
 [1263] "Dalteparin"                                                                                                                                                           
 [1264] "Bispecific_Antibody"                                                                                                                                                  
 [1265] "Conjugate_Vaccine"                                                                                                                                                    
 [1266] "Superantigen"                                                                                                                                                         
 [1267] "Yeast_Artificial_Chromosome"                                                                                                                                          
 [1268] "Zorubicin"                                                                                                                                                            
 [1269] "Recombinant_Glial_Cell-Line_Derived_Neurotrophic_Factor"                                                                                                              
 [1270] "Sorivudine"                                                                                                                                                           
 [1271] "Perillyl_Alcohol"                                                                                                                                                     
 [1272] "Radicicol"                                                                                                                                                            
 [1273] "Dihydrolenperone"                                                                                                                                                     
 [1274] "Tirapazamine"                                                                                                                                                         
 [1275] "Dexniguldipine"                                                                                                                                                       
 [1276] "Therapeutic_Fibroblast_Growth_Factor_3"                                                                                                                               
 [1277] "Therapeutic_Human_Macrophage_Inflammatory_Protein-1_Beta"                                                                                                             
 [1278] "Mycophenolate_Mofetil"                                                                                                                                                
 [1279] "In_111_Satumomab_Pendetide"                                                                                                                                           
 [1280] "Loxoribine"                                                                                                                                                           
 [1281] "Lamivudine"                                                                                                                                                           
 [1282] "Bizelesin"                                                                                                                                                            
 [1283] "Recombinant_Soluble_T4"                                                                                                                                               
 [1284] "Filgrastim"                                                                                                                                                           
 [1285] "Ziconotide"                                                                                                                                                           
 [1286] "Denileukin_Diftitox"                                                                                                                                                  
 [1287] "Milodistim"                                                                                                                                                           
 [1288] "QS21"                                                                                                                                                                 
 [1289] "ALVAC_Vaccine"                                                                                                                                                        
 [1290] "Damnacanthal"                                                                                                                                                         
 [1291] "Amoxicillin-Clavulanic_Acid"                                                                                                                                          
 [1292] "Squalamine"                                                                                                                                                           
 [1293] "Recombinant_Betacellulin"                                                                                                                                             
 [1294] "Tyrphostin_A25"                                                                                                                                                       
 [1295] "Rubitecan"                                                                                                                                                            
 [1296] "GEM_91"                                                                                                                                                               
 [1297] "Lavendustin_C"                                                                                                                                                        
 [1298] "Aminocamptothecin"                                                                                                                                                    
 [1299] "Therapeutic_Interleukin-13"                                                                                                                                           
 [1300] "Taxane_Compound"                                                                                                                                                      
 [1301] "Tyrphostin_AG_879"                                                                                                                                                    
 [1302] "Sargramostim"                                                                                                                                                         
 [1303] "Satraplatin"                                                                                                                                                          
 [1304] "Arcitumomab"                                                                                                                                                          
 [1305] "Intoplicine"                                                                                                                                                          
 [1306] "DOTMP"                                                                                                                                                                
 [1307] "SR_49059"                                                                                                                                                             
 [1308] "Aldesleukin"                                                                                                                                                          
 [1309] "_2_Fluoro-2_3_Dideoxyadenosine"                                                                                                                                       
 [1310] "Penicillin_Antibiotic"                                                                                                                                                
 [1311] "Phenyl_Acetate"                                                                                                                                                       
 [1312] "Fiber"                                                                                                                                                                
 [1313] "Deoxyadenosine"                                                                                                                                                       
 [1314] "Therapeutic_Epidermal_Growth_Factor"                                                                                                                                  
 [1315] "Nutritional_Supplement"                                                                                                                                               
 [1316] "Opioid"                                                                                                                                                               
 [1317] "Prazosin_Hydrochloride"                                                                                                                                               
 [1318] "Retrotransposon"                                                                                                                                                      
 [1319] "Neuroprotective_Agent"                                                                                                                                                
 [1320] "DNA_Adduct"                                                                                                                                                           
 [1321] "Radioimmunoconjugate"                                                                                                                                                 
 [1322] "Immunoconjugate"                                                                                                                                                      
 [1323] "Analog"                                                                                                                                                               
 [1324] "Agonist"                                                                                                                                                              
 [1325] "Ranimustine"                                                                                                                                                          
 [1326] "Lisofylline"                                                                                                                                                          
 [1327] "Distamycin"                                                                                                                                                           
 [1328] "Raloxifene"                                                                                                                                                           
 [1329] "Roquinimex"                                                                                                                                                           
 [1330] "Teloxantrone"                                                                                                                                                         
 [1331] "Losoxantrone"                                                                                                                                                         
 [1332] "Troglitazone"                                                                                                                                                         
 [1333] "Lanreotide"                                                                                                                                                           
 [1334] "Liarozole_Fumarate"                                                                                                                                                   
 [1335] "RG_12915"                                                                                                                                                             
 [1336] "Docetaxel"                                                                                                                                                            
 [1337] "Letrozole"                                                                                                                                                            
 [1338] "Risedronate_Sodium"                                                                                                                                                   
 [1339] "Batimastat"                                                                                                                                                           
 [1340] "Piperacillin-Tazobactam"                                                                                                                                              
 [1341] "Therapeutic_Eotaxin"                                                                                                                                                  
 [1342] "Gutolactone"                                                                                                                                                          
 [1343] "Pemetrexed"                                                                                                                                                           
 [1344] "Methionine_C_11"                                                                                                                                                      
 [1345] "Bruceanol_D"                                                                                                                                                          
 [1346] "Bruceanol_E"                                                                                                                                                          
 [1347] "Bruceanol_F"                                                                                                                                                          
 [1348] "Therapeutic_Fas_Ligand"                                                                                                                                               
 [1349] "Tezacitabine"                                                                                                                                                         
 [1350] "Tyrphostin_A46"                                                                                                                                                       
 [1351] "LR-3001"                                                                                                                                                              
 [1352] "KW_2189"                                                                                                                                                              
 [1353] "Peptide_946"                                                                                                                                                          
 [1354] "Depsipeptide"                                                                                                                                                         
 [1355] "Therapeutic_Interleukin-15"                                                                                                                                           
 [1356] "Cryptophycin"                                                                                                                                                         
 [1357] "Compound_32"                                                                                                                                                          
 [1358] "Therapeutic_OX40_Ligand"                                                                                                                                              
 [1359] "BR96_sFv-PE40"                                                                                                                                                        
 [1360] "Fat-Soluble_Vitamin"                                                                                                                                                  
 [1361] "Water-Soluble_Vitamin"                                                                                                                                                
 [1362] "Vasopressin_Tannate_in_Oil"                                                                                                                                           
 [1363] "Thyroid_Agent"                                                                                                                                                        
 [1364] "Edrecolomab"                                                                                                                                                          
 [1365] "Doxorubicin_Hydrochloride_Liposome"                                                                                                                                   
 [1366] "Purine_Antagonist"                                                                                                                                                    
 [1367] "Pyrimidine_Antagonist"                                                                                                                                                
 [1368] "Extended_Spectrum_Penicillin_Antibiotic"                                                                                                                              
 [1369] "L-Leucovorin"                                                                                                                                                         
 [1370] "Brequinar"                                                                                                                                                            
 [1371] "Monoclonal_Antibody_Lym-1"                                                                                                                                            
 [1372] "Re_186_Hydroxyethylidene_Diphosphonate"                                                                                                                               
 [1373] "Dexverapamil"                                                                                                                                                         
 [1374] "Pyrazoloacridine"                                                                                                                                                     
 [1375] "Aloe_Vera_Gel"                                                                                                                                                        
 [1376] "Amphotericin_B-Lipid_Complex"                                                                                                                                         
 [1377] "Strontium-89"                                                                                                                                                         
 [1378] "Dihydrosphingosine"                                                                                                                                                   
 [1379] "Daclizumab"                                                                                                                                                           
 [1380] "Monoclonal_Antibody_Ch14_18"                                                                                                                                          
 [1381] "Flavopiridol"                                                                                                                                                         
 [1382] "Recombinant_Viral_Vaccine"                                                                                                                                            
 [1383] "Incomplete_Freunds_Adjuvant"                                                                                                                                          
 [1384] "Alitretinoin"                                                                                                                                                         
 [1385] "Disaccharide_Tripeptide_Glycerol_Dipalmitoyl"                                                                                                                         
 [1386] "Sedoxantrone_Trihydrochloride"                                                                                                                                        
 [1387] "Nolatrexed"                                                                                                                                                           
 [1388] "Bispecific_Antibody_520C9XH22"                                                                                                                                        
 [1389] "Eflornithine_Hydrochloride"                                                                                                                                           
 [1390] "Anti-DNA_Antibody"                                                                                                                                                    
 [1391] "Benzydamine_Hydrochloride"                                                                                                                                            
 [1392] "Carubicin_Hydrochloride"                                                                                                                                              
 [1393] "Daunomycin"                                                                                                                                                           
 [1394] "Loperamide_Hydrochloride"                                                                                                                                             
 [1395] "Lubricant"                                                                                                                                                            
 [1396] "Levofloxacin"                                                                                                                                                         
 [1397] "Idarubicin_Hydrochloride"                                                                                                                                             
 [1398] "Ganciclovir_Sodium"                                                                                                                                                   
 [1399] "Reverse_Transcriptase_Inhibitor"                                                                                                                                      
 [1400] "Antineoplastic_Alkylating_Agent"                                                                                                                                      
 [1401] "Therapeutic_Beta_Chemokine"                                                                                                                                           
 [1402] "Therapeutic_Alpha_Chemokine"                                                                                                                                          
 [1403] "Therapeutic_Chemokine"                                                                                                                                                
 [1404] "Anthracycline_Antibiotic"                                                                                                                                             
 [1405] "Tetracycline_Antibiotic"                                                                                                                                              
 [1406] "ZD0101"                                                                                                                                                               
 [1407] "Gusperimus_Trihydrochloride"                                                                                                                                          
 [1408] "Gusperimus"                                                                                                                                                           
 [1409] "Bicalutamide"                                                                                                                                                         
 [1410] "Cidofovir"                                                                                                                                                            
 [1411] "Vorozole"                                                                                                                                                             
 [1412] "Saquinavir_Mesylate"                                                                                                                                                  
 [1413] "Tallimustine"                                                                                                                                                         
 [1414] "DC-Chol_Liposome"                                                                                                                                                     
 [1415] "Tecogalan_Sodium"                                                                                                                                                     
 [1416] "Lobradimil"                                                                                                                                                           
 [1417] "Anastrozole"                                                                                                                                                          
 [1418] "Therapeutic_Lymphotoxin_Beta"                                                                                                                                         
 [1419] "Ritonavir"                                                                                                                                                            
 [1420] "Lurtotecan"                                                                                                                                                           
 [1421] "_7-Cyanoquinocarcinol"                                                                                                                                                
 [1422] "Glufosfamide"                                                                                                                                                         
 [1423] "Antineoplaston_AS2-1"                                                                                                                                                 
 [1424] "KRN5500"                                                                                                                                                              
 [1425] "LU_79553"                                                                                                                                                             
 [1426] "Lavendustin_B"                                                                                                                                                        
 [1427] "BR96-Doxorubicin_Immunoconjugate"                                                                                                                                     
 [1428] "BAGE_Tumor_Antigen"                                                                                                                                                   
 [1429] "LMB-7_Immunotoxin"                                                                                                                                                    
 [1430] "Rebeccamycin_Analogue"                                                                                                                                                
 [1431] "Ho_166_DOTMP"                                                                                                                                                         
 [1432] "Epothilone_A"                                                                                                                                                         
 [1433] "Epothilone_B"                                                                                                                                                         
 [1434] "Nelfinavir_Mesylate"                                                                                                                                                  
 [1435] "PD-98059"                                                                                                                                                             
 [1436] "LY293111"                                                                                                                                                             
 [1437] "Lewis_Y_Antigen"                                                                                                                                                      
 [1438] "Polyandrol"                                                                                                                                                           
 [1439] "ZD9331"                                                                                                                                                               
 [1440] "Therapeutic_Interleukin-14"                                                                                                                                           
 [1441] "Recombinant_Inhibin_A"                                                                                                                                                
 [1442] "ILX-295501"                                                                                                                                                           
 [1443] "Polyvalent_Melanoma_Vaccine"                                                                                                                                          
 [1444] "Cemadotin"                                                                                                                                                            
 [1445] "Bexarotene"                                                                                                                                                           
 [1446] "Therapeutic_Steroid_Hormone"                                                                                                                                          
 [1447] "Xanthine_Oxidase_Inhibitor"                                                                                                                                           
 [1448] "Carbon-14"                                                                                                                                                            
 [1449] "Iodine_131"                                                                                                                                                           
 [1450] "Indium_111"                                                                                                                                                           
 [1451] "Yttrium_90"                                                                                                                                                           
 [1452] "Technetium_99m"                                                                                                                                                       
 [1453] "Pneumococcal_Polyvalent_Vaccine"                                                                                                                                      
 [1454] "Corynebacterium_Granulosum"                                                                                                                                           
 [1455] "Methyl_Ether"                                                                                                                                                         
 [1456] "Recombinant_Human_Methionyl_Stem_Cell_Factor"                                                                                                                         
 [1457] "Trastuzumab"                                                                                                                                                          
 [1458] "ALVAC-CEA_Vaccine"                                                                                                                                                    
 [1459] "Allovectin-7"                                                                                                                                                         
 [1460] "Peldesine"                                                                                                                                                            
 [1461] "Motexafin_Lutetium"                                                                                                                                                   
 [1462] "Marimastat"                                                                                                                                                           
 [1463] "Biricodar_Dicitrate"                                                                                                                                                  
 [1464] "Multivitamin"                                                                                                                                                         
 [1465] "HMG-CoA_Reductase_Inhibitor"                                                                                                                                          
 [1466] "Rhenium_186"                                                                                                                                                          
 [1467] "Opiate"                                                                                                                                                               
 [1468] "Warfarin_Sodium"                                                                                                                                                      
 [1469] "Melengestrol"                                                                                                                                                         
 [1470] "Anti-HIV_Agent"                                                                                                                                                       
 [1471] "Nucleic_Acid_Synthesis_Inhibitor"                                                                                                                                     
 [1472] "Indinavir"                                                                                                                                                            
 [1473] "Antineoplastic_Vaccine"                                                                                                                                               
 [1474] "Therapeutic_Interferon-alpha_Inducible_Protein_10"                                                                                                                    
 [1475] "Trapoxin"                                                                                                                                                             
 [1476] "Tyrphostin_A30"                                                                                                                                                       
 [1477] "RG_14620"                                                                                                                                                             
 [1478] "Therapeutic_Platelet_Derived_Growth_Factor_Beta_Chain"                                                                                                                
 [1479] "Temoporfin"                                                                                                                                                           
 [1480] "Ibandronate"                                                                                                                                                          
 [1481] "Recombinant_Human_Macrophage_Chemoattractant_Protein-2"                                                                                                               
 [1482] "In_111_Pentetreotide"                                                                                                                                                 
 [1483] "Sardomozide"                                                                                                                                                          
 [1484] "Therapeutic_Fibroblast_Growth_Factor-2"                                                                                                                               
 [1485] "Tyrphostin_B46"                                                                                                                                                       
 [1486] "Curacin_B"                                                                                                                                                            
 [1487] "Curacin_C"                                                                                                                                                            
 [1488] "Curacin_A"                                                                                                                                                            
 [1489] "Exatecan_Mesylate"                                                                                                                                                    
 [1490] "Therapeutic_Interleukin-18"                                                                                                                                           
 [1491] "Alemtuzumab"                                                                                                                                                          
 [1492] "L-744_832"                                                                                                                                                            
 [1493] "Tyrphostin_A47"                                                                                                                                                       
 [1494] "Therapeutic_Interleukin-17"                                                                                                                                           
 [1495] "Therapeutic_TNF-Related_Apoptosis-Inducing_Ligand"                                                                                                                    
 [1496] "ZD2767"                                                                                                                                                               
 [1497] "Imatinib"                                                                                                                                                             
 [1498] "Tyrphostin_AG_825"                                                                                                                                                    
 [1499] "Aplidine"                                                                                                                                                             
 [1500] "Sialyl_Tn-KLH_Vaccine"                                                                                                                                                
 [1501] "Ecteinascidin_743"                                                                                                                                                    
 [1502] "Gastrin_Immunotoxin"                                                                                                                                                  
 [1503] "c-RAF_Antisense"                                                                                                                                                      
 [1504] "Bruceanol_G"                                                                                                                                                          
 [1505] "Bruceanol_H"                                                                                                                                                          
 [1506] "Oxamflatin"                                                                                                                                                           
 [1507] "Fungicide"                                                                                                                                                            
 [1508] "Phosphorus-32"                                                                                                                                                        
 [1509] "Zoledronate"                                                                                                                                                          
 [1510] "RPR_109881A"                                                                                                                                                          
 [1511] "Vaccinia_CEA_Vaccine"                                                                                                                                                 
 [1512] "Rituximab"                                                                                                                                                            
 [1513] "Tipifarnib"                                                                                                                                                           
 [1514] "Nelarabine"                                                                                                                                                           
 [1515] "Tanomastat"                                                                                                                                                           
 [1516] "MEN-10755"                                                                                                                                                            
 [1517] "Voriconazole"                                                                                                                                                         
 [1518] "Agent"                                                                                                                                                                
 [1519] "Particulate"                                                                                                                                                          
 [1520] "Pentetic_Acid_Calcium"                                                                                                                                                
 [1521] "Myeloablative_Agonist"                                                                                                                                                
 [1522] "Therapeutic_Gamma_Chemokine"                                                                                                                                          
 [1523] "Tyrphostin_AG_126"                                                                                                                                                    
 [1524] "Therapeutic_Flt3_Ligand"                                                                                                                                              
 [1525] "Tyrphostin_AG_1478"                                                                                                                                                   
 [1526] "Monoclonal_Antibody_HuG1-M195"                                                                                                                                        
 [1527] "Irofulven"                                                                                                                                                            
 [1528] "UDP-4"                                                                                                                                                                
 [1529] "PEG_Recombinant_Human_Megakaryocyte_Growth_and_Development_Factor"                                                                                                    
 [1530] "KRN7000"                                                                                                                                                              
 [1531] "Tyrphostin_AG_957"                                                                                                                                                    
 [1532] "Oprelvekin"                                                                                                                                                           
 [1533] "Cetuximab"                                                                                                                                                            
 [1534] "Caspofungin_Acetate"                                                                                                                                                  
 [1535] "SU5402"                                                                                                                                                               
 [1536] "SU4984"                                                                                                                                                               
 [1537] "Perifosine"                                                                                                                                                           
 [1538] "Celecoxib"                                                                                                                                                            
 [1539] "CT2584_HMS"                                                                                                                                                           
 [1540] "_714-X"                                                                                                                                                               
 [1541] "Tyrphostin_AG_1296"                                                                                                                                                   
 [1542] "G28-5_sFv-PE40"                                                                                                                                                       
 [1543] "TAS-103"                                                                                                                                                              
 [1544] "Histamine_Dihydrochloride"                                                                                                                                            
 [1545] "Sodium_Methotrexate"                                                                                                                                                  
 [1546] "Aminobenzoate_Potassium"                                                                                                                                              
 [1547] "Organic_Solvents"                                                                                                                                                     
 [1548] "Amphotericin_B_Liposomal"                                                                                                                                             
 [1549] "Vincristine_Sulfate"                                                                                                                                                  
 [1550] "Aromatase_Inhibitor"                                                                                                                                                  
 [1551] "Chloride_Ion"                                                                                                                                                         
 [1552] "Angiogenesis_Inhibitor"                                                                                                                                               
 [1553] "Chemical_Carcinogen"                                                                                                                                                  
 [1554] "Multidrug_Resistance_Modulator"                                                                                                                                       
 [1555] "Flavonoid"                                                                                                                                                            
 [1556] "Peptide_Hormone"                                                                                                                                                      
 [1557] "Cruciferous_Vegetable"                                                                                                                                                
 [1558] "Topoisomerase_Inhibitor"                                                                                                                                              
 [1559] "Aptamer"                                                                                                                                                              
 [1560] "Therapeutic_Fibroblast_Growth_Factor_1"                                                                                                                               
 [1561] "Pollutant"                                                                                                                                                            
 [1562] "Peptide_Vaccine"                                                                                                                                                      
 [1563] "Blood_Urea"                                                                                                                                                           
 [1564] "Recombinant_Interleukin-1-alpha"                                                                                                                                      
 [1565] "Pentosan_Polysulfate"                                                                                                                                                 
 [1566] "Toremifene_Citrate"                                                                                                                                                   
 [1567] "Tyrphostin_Compound"                                                                                                                                                  
 [1568] "Tritylcysteine"                                                                                                                                                       
 [1569] "Benzodepa"                                                                                                                                                            
 [1570] "Meturedepa"                                                                                                                                                           
 [1571] "Trypan_Red"                                                                                                                                                           
 [1572] "Raloxifene_Hydrochloride"                                                                                                                                             
 [1573] "Sergiolide"                                                                                                                                                           
 [1574] "Bruceanol_B"                                                                                                                                                          
 [1575] "Bruceanol_A"                                                                                                                                                          
 [1576] "Interferon_Alfacon-1"                                                                                                                                                 
 [1577] "Chaparrin"                                                                                                                                                            
 [1578] "Bruceanol_C"                                                                                                                                                          
 [1579] "Tyrphostin_A23"                                                                                                                                                       
 [1580] "Aminogenistein"                                                                                                                                                       
 [1581] "Picrasinoside_H"                                                                                                                                                      
 [1582] "Declopramide"                                                                                                                                                         
 [1583] "Ethynyluracil"                                                                                                                                                        
 [1584] "Isobrucein_B"                                                                                                                                                         
 [1585] "Cancell"                                                                                                                                                              
 [1586] "CTP-37"                                                                                                                                                               
 [1587] "AMD3100"                                                                                                                                                              
 [1588] "Tyrphostin_B42"                                                                                                                                                       
 [1589] "Atrasentan"                                                                                                                                                           
 [1590] "Tyrphostin_B56"                                                                                                                                                       
 [1591] "Tyrphostin_B50"                                                                                                                                                       
 [1592] "Omapatrilat"                                                                                                                                                          
 [1593] "Piposulfan"                                                                                                                                                           
 [1594] "Monoclonal_Antibody_B43_13"                                                                                                                                           
 [1595] "Tyrphostin_B48"                                                                                                                                                       
 [1596] "Cyanovirin-N"                                                                                                                                                         
 [1597] "AG_1517"                                                                                                                                                              
 [1598] "ISIS_3521"                                                                                                                                                            
 [1599] "Infliximab"                                                                                                                                                           
 [1600] "GEM_132"                                                                                                                                                              
 [1601] "Recombinant_Methionyl_Human_Brain-Derived_Factor"                                                                                                                     
 [1602] "Therapeutic_Secondary_Lymphoid-Tissue_Chemokine"                                                                                                                      
 [1603] "ZD0473"                                                                                                                                                               
 [1604] "Capecitabine"                                                                                                                                                         
 [1605] "Paclitaxel_Polyglutamate"                                                                                                                                             
 [1606] "Suberoylanilide_Hydroxamic_Acid"                                                                                                                                      
 [1607] "Carboxycinnamic_Acid_Bishydroxamide"                                                                                                                                  
 [1608] "Neovastat"                                                                                                                                                            
 [1609] "Detox"                                                                                                                                                                
 [1610] "Vitaxin"                                                                                                                                                              
 [1611] "Urinary_Bladder_Tumor_Antigen"                                                                                                                                        
 [1612] "Cigarette"                                                                                                                                                            
 [1613] "Soy_Protein_Isolate"                                                                                                                                                  
 [1614] "Raltitrexed"                                                                                                                                                          
 [1615] "Arzoxifene"                                                                                                                                                           
 [1616] "Gemtuzumab_Ozogamicin"                                                                                                                                                
 [1617] "Biafine_Cream"                                                                                                                                                        
 [1618] "_90Y-DOTA-Biotin"                                                                                                                                                     
 [1619] "Samarium_153"                                                                                                                                                         
 [1620] "GEM_231"                                                                                                                                                              
 [1621] "Prinomastat"                                                                                                                                                          
 [1622] "Y_90_Ibritumomab_Tiuxetan"                                                                                                                                            
 [1623] "Cigar"                                                                                                                                                                
 [1624] "Nutrient"                                                                                                                                                             
 [1625] "Aromatic_Amines"                                                                                                                                                      
 [1626] "Substance_of_Abuse"                                                                                                                                                   
 [1627] "Ursodiol"                                                                                                                                                             
 [1628] "Hydrocortisone_Sodium_Succinate"                                                                                                                                      
 [1629] "Mitomycin_C"                                                                                                                                                          
 [1630] "Selective_Estrogen_Receptor_Modulator"                                                                                                                                
 [1631] "Therapeutic_Follicle_Stimulating_Hormone"                                                                                                                             
 [1632] "Interferon_Beta-1A"                                                                                                                                                   
 [1633] "Suradista"                                                                                                                                                            
 [1634] "U-0126"                                                                                                                                                               
 [1635] "Cryptophycin_52"                                                                                                                                                      
 [1636] "BBR_3464"                                                                                                                                                             
 [1637] "PC-SPES"                                                                                                                                                              
 [1638] "Lonafarnib"                                                                                                                                                           
 [1639] "Melanoma_Theraccine"                                                                                                                                                  
 [1640] "Semaxanib"                                                                                                                                                            
 [1641] "Rofecoxib"                                                                                                                                                            
 [1642] "S-1"                                                                                                                                                                  
 [1643] "Cilengitide"                                                                                                                                                          
 [1644] "T138067"                                                                                                                                                              
 [1645] "Radicicol_6-Oxime"                                                                                                                                                    
 [1646] "Paroxetine_Hydrochloride"                                                                                                                                             
 [1647] "Saw_Palmetto_Berry_Extract"                                                                                                                                           
 [1648] "Lepirudin"                                                                                                                                                            
 [1649] "L-778_123"                                                                                                                                                            
 [1650] "Iodine_I_125"                                                                                                                                                         
 [1651] "BL22_Immunotoxin"                                                                                                                                                     
 [1652] "BMS-184476"                                                                                                                                                           
 [1653] "CCI-779"                                                                                                                                                              
 [1654] "PEG-Interferon_Alfa-2B"                                                                                                                                               
 [1655] "Leridistim"                                                                                                                                                           
 [1656] "Therapeutic_Transforming_Growth_Factor-Beta_3"                                                                                                                        
 [1657] "Suramin_Sodium"                                                                                                                                                       
 [1658] "Aminolevulinic_Acid_Hydrochloride"                                                                                                                                    
 [1659] "Micafungin"                                                                                                                                                           
 [1660] "Bortezomib"                                                                                                                                                           
 [1661] "CHS_828"                                                                                                                                                              
 [1662] "L-377_202"                                                                                                                                                            
 [1663] "Pegfilgrastim"                                                                                                                                                        
 [1664] "Gefitinib"                                                                                                                                                            
 [1665] "BMS214662"                                                                                                                                                            
 [1666] "Monoclonal_Antibody_ABX-EGF"                                                                                                                                          
 [1667] "BMS-247550"                                                                                                                                                           
 [1668] "BMS-188797"                                                                                                                                                           
 [1669] "Bacterial_Artificial_Chromosome"                                                                                                                                      
 [1670] "Aclacinomycin_B"                                                                                                                                                      
 [1671] "Prednisolone_Sodium_Metasulphobenzoate"                                                                                                                               
 [1672] "MS-27-275"                                                                                                                                                            
 [1673] "MS-247"                                                                                                                                                               
 [1674] "Angiozyme"                                                                                                                                                            
 [1675] "GL331"                                                                                                                                                                
 [1676] "Orataxel"                                                                                                                                                             
 [1677] "PTK787"                                                                                                                                                               
 [1678] "Valdecoxib"                                                                                                                                                           
 [1679] "Oblimersen"                                                                                                                                                           
 [1680] "PKI166"                                                                                                                                                               
 [1681] "Midostaurin"                                                                                                                                                          
 [1682] "SR-45023A"                                                                                                                                                            
 [1683] "ERA_923"                                                                                                                                                              
 [1684] "BMS-275291"                                                                                                                                                           
 [1685] "Lurtotecan_Liposome"                                                                                                                                                  
 [1686] "Karenitecin"                                                                                                                                                          
 [1687] "Darbepoetin_Alfa"                                                                                                                                                     
 [1688] "MGN3"                                                                                                                                                                 
 [1689] "CI-1033"                                                                                                                                                              
 [1690] "Motexafin_Gadolinium"                                                                                                                                                 
 [1691] "NB1011"                                                                                                                                                               
 [1692] "ILX23-7553"                                                                                                                                                           
 [1693] "SU6668"                                                                                                                                                               
 [1694] "GEM_92"                                                                                                                                                               
 [1695] "BAY_56-3722"                                                                                                                                                          
 [1696] "Epratuzumab"                                                                                                                                                          
 [1697] "NM-3"                                                                                                                                                                 
 [1698] "Brostallicin"                                                                                                                                                         
 [1699] "Adenovirus_Vector"                                                                                                                                                    
 [1700] "Anti-Progestin"                                                                                                                                                       
 [1701] "Chemopreventive_Agent"                                                                                                                                                
 [1702] "Dolastatin_Compound"                                                                                                                                                  
 [1703] "Environmental_Estrogen"                                                                                                                                               
 [1704] "Polyhalogenated_Hydrocarbons"                                                                                                                                         
 [1705] "Monoclonal_Antibody_for_Clinical_Diagnosis"                                                                                                                           
 [1706] "Phosphorylated_Peptide"                                                                                                                                               
 [1707] "Physical_Carcinogens"                                                                                                                                                 
 [1708] "Physiology-Regulatory_Factor"                                                                                                                                         
 [1709] "Pox_Virus_Vectors"                                                                                                                                                    
 [1710] "Pteridines_Folic_Acid_Analogs"                                                                                                                                        
 [1711] "Ras_Inhibitor"                                                                                                                                                        
 [1712] "Intracellular_Second_Messenger"                                                                                                                                       
 [1713] "Topoisomerase-I_Inhibitor"                                                                                                                                            
 [1714] "Triterpenoid_Compound"                                                                                                                                                
 [1715] "Tumor_Specific_Peptide"                                                                                                                                               
 [1716] "Drug_Natural_Product"                                                                                                                                                 
 [1717] "Drugs_and_Chemicals"                                                                                                                                                  
 [1718] "Pharmacologic_Substance"                                                                                                                                              
 [1719] "Luteinizing_Hormone-releasing_Hormone_Agonist"                                                                                                                        
 [1720] "Organo-Metallic_Phosphorus_Boron_Derivatives"                                                                                                                         
 [1721] "Therapeutic_Chemokine_Other"                                                                                                                                          
 [1722] "Drugs_and_Chemicals_Structural_Classification"                                                                                                                        
 [1723] "Drugs_and_Chemicals_Functional_Classification"                                                                                                                        
 [1724] "Aromatic_Compounds"                                                                                                                                                   
 [1725] "Nitrogen_Compound"                                                                                                                                                    
 [1726] "P1-derived_Artificial_Chromosome"                                                                                                                                     
 [1727] "P1_Vector"                                                                                                                                                            
 [1728] "Plasmid_Cloning_Vector"                                                                                                                                               
 [1729] "Attenuated_Live_Virus_Vaccine"                                                                                                                                        
 [1730] "Prothymosin-L"                                                                                                                                                        
 [1731] "Epothilone_Compound"                                                                                                                                                  
 [1732] "Nutritional_Toxin"                                                                                                                                                    
 [1733] "Curacin_Compound"                                                                                                                                                     
 [1734] "Hen_Egg_Lysozyme"                                                                                                                                                     
 [1735] "Heterocyclic_Amines"                                                                                                                                                  
 [1736] "Enediyne_Antitumor_Antibiotic"                                                                                                                                        
 [1737] "Dynemicin"                                                                                                                                                            
 [1738] "Signaling_Molecule"                                                                                                                                                   
 [1739] "Dietary_Component"                                                                                                                                                    
 [1740] "Antineoplastic_Plant_Product"                                                                                                                                         
 [1741] "Chemical_Modifier"                                                                                                                                                    
 [1742] "Ring_Compound"                                                                                                                                                        
 [1743] "Differentiation_Inducer"                                                                                                                                              
 [1744] "Anticachexia_Agent"                                                                                                                                                   
 [1745] "Transcripts"                                                                                                                                                          
 [1746] "Diagnostic_Reagent"                                                                                                                                                   
 [1747] "Monoclonal_Antibody_BrE-3"                                                                                                                                            
 [1748] "GAGE"                                                                                                                                                                 
 [1749] "Element_or_Isotope"                                                                                                                                                   
 [1750] "Therapeutic_Tumor_Necrosis_Factor_Family_Protein"                                                                                                                     
 [1751] "Linker-Oligonucleotide"                                                                                                                                               
 [1752] "Holmium_166"                                                                                                                                                          
 [1753] "YAC_Clone"                                                                                                                                                            
 [1754] "Fruit_and_Vegetable"                                                                                                                                                  
 [1755] "Histone_Deacetylase_Inhibitor"                                                                                                                                        
 [1756] "Organic_Oxoacids"                                                                                                                                                     
 [1757] "_2-Amino-9_10-Epoxy-8-Oxodecanoic_Acid"                                                                                                                               
 [1758] "Food_and_Food_Product"                                                                                                                                                
 [1759] "Nut_Oil"                                                                                                                                                              
 [1760] "Human_Papilloma_Virus_Vaccine"                                                                                                                                        
 [1761] "Interferon_Alpha-2a"                                                                                                                                                  
 [1762] "Recombinant_Interferon_Alfa-2b"                                                                                                                                       
 [1763] "Nutraceutical"                                                                                                                                                        
 [1764] "Vanilloid"                                                                                                                                                            
 [1765] "Tobacco-Associated_Carcinogen"                                                                                                                                        
 [1766] "_125IUdR"                                                                                                                                                             
 [1767] "Monoclonal_Antibody_81C6"                                                                                                                                             
 [1768] "Monoclonal_Antibody_170"                                                                                                                                              
 [1769] "Monoclonal_Antibody_G-250"                                                                                                                                            
 [1770] "Monoclonal_Antibody_BC8"                                                                                                                                              
 [1771] "Gene_Therapy_Agent"                                                                                                                                                   
 [1772] "Retro-Inverso_Peptide"                                                                                                                                                
 [1773] "Miniantibody"                                                                                                                                                         
 [1774] "Lutein"                                                                                                                                                               
 [1775] "Image_Enhancement_Agent"                                                                                                                                              
 [1776] "Tyrosine_Kinase_Inhibitor"                                                                                                                                            
 [1777] "Topoisomerase-II_Inhibitor"                                                                                                                                           
 [1778] "Dolastatin_9"                                                                                                                                                         
 [1779] "Matrix_Metalloproteinase_Inhibitor"                                                                                                                                   
 [1780] "Angiogenesis_Activator_Inhibitor"                                                                                                                                     
 [1781] "Deferoxamine_Hydrochloride"                                                                                                                                           
 [1782] "CancerVax"                                                                                                                                                            
 [1783] "Quassinoid_Agent"                                                                                                                                                     
 [1784] "Bruceanol_Agent"                                                                                                                                                      
 [1785] "Depsipeptide_Antibiotic"                                                                                                                                              
 [1786] "ALVAC-CEA_B7_1_Vaccine"                                                                                                                                               
 [1787] "GVAX_Cancer_Vaccine"                                                                                                                                                  
 [1788] "GVAX_Lung_Cancer_Vaccine"                                                                                                                                             
 [1789] "Autologous_Cell_Vaccine"                                                                                                                                              
 [1790] "Autologous-Cell_Melanoma_Vaccine"                                                                                                                                     
 [1791] "Autologous_Dinitrophenyl_Vaccine"                                                                                                                                     
 [1792] "Allogenic_Cell_Vaccine"                                                                                                                                               
 [1793] "OncoVAX"                                                                                                                                                              
 [1794] "APC8015_Vaccine"                                                                                                                                                      
 [1795] "p53_Peptide_Vaccine"                                                                                                                                                  
 [1796] "Dendritic_Cell_Tumor_Peptide_Vaccine"                                                                                                                                 
 [1797] "Dendritic_Cell_Tumor_Cell_Lysate_Vaccine"                                                                                                                             
 [1798] "Mannosylerythritol_Lipid"                                                                                                                                             
 [1799] "_2-3-Ethylureido_Pyridine"                                                                                                                                            
 [1800] "_4-Methyl-2-3-Ethylureido_Pyridine"                                                                                                                                   
 [1801] "_2_6-Dimethyl-2-3-Ethylureido_Pyridine"                                                                                                                               
 [1802] "_2_6-Dimethyl-4-3-Ethylureido_Pyridine"                                                                                                                               
 [1803] "_6-3-Ethylureido_Uridine"                                                                                                                                             
 [1804] "_1_3-Dimethyl-6-3-Ethylureido_Uridine"                                                                                                                                
 [1805] "_4-3-Ethylureido_Cytosine"                                                                                                                                            
 [1806] "_5-Methyl-4-3-Ethylureido_Cytosine"                                                                                                                                   
 [1807] "CD30_Immunotoxin"                                                                                                                                                     
 [1808] "TP3_Immunotoxin"                                                                                                                                                      
 [1809] "J591_Monoclonal_Antibody"                                                                                                                                             
 [1810] "CD22_Immunotoxin"                                                                                                                                                     
 [1811] "Antihuman_Endoglin_Immunotoxin"                                                                                                                                       
 [1812] "SGN-15"                                                                                                                                                               
 [1813] "SGN-14"                                                                                                                                                               
 [1814] "SGN-17_19"                                                                                                                                                            
 [1815] "SGN-30"                                                                                                                                                               
 [1816] "MDX-447"                                                                                                                                                              
 [1817] "MDX-220"                                                                                                                                                              
 [1818] "MDX-22"                                                                                                                                                               
 [1819] "MDX-4"                                                                                                                                                                
 [1820] "EMD_72000"                                                                                                                                                            
 [1821] "BEC-2"                                                                                                                                                                
 [1822] "Novel_Erythropoiesis_Stimulating_Protein"                                                                                                                             
 [1823] "Abarelix"                                                                                                                                                             
 [1824] "GEM_220"                                                                                                                                                              
 [1825] "Steroidal_Aromatase_Inhibitor"                                                                                                                                        
 [1826] "Non-Steroidal_Aromatase_Inhibitor"                                                                                                                                    
 [1827] "Dihydropyrimidine_Dehydrogenase_Inhibitor"                                                                                                                            
 [1828] "Farnesyl_Transferase_Inhibitor"                                                                                                                                       
 [1829] "Thymidylate_Synthase_Inhibitor"                                                                                                                                       
 [1830] "Gonadotropin-Releasing_Hormone_Analog"                                                                                                                                
 [1831] "Autologous-Cell_Leukemia_Vaccine"                                                                                                                                     
 [1832] "ISIS_2503"                                                                                                                                                            
 [1833] "Tyrphostin_A8"                                                                                                                                                        
 [1834] "Tyrphostin_A9"                                                                                                                                                        
 [1835] "Tyrphostin_A48"                                                                                                                                                       
 [1836] "Tyrphostin_AG_370"                                                                                                                                                    
 [1837] "Tyrphostin_B44"                                                                                                                                                       
 [1838] "Tyrphostin_AG_1288"                                                                                                                                                   
 [1839] "Tyrphostin_AG_1295"                                                                                                                                                   
 [1840] "Tyrphostin_AG_1433"                                                                                                                                                   
 [1841] "Bis-Tyrphostin"                                                                                                                                                       
 [1842] "Tyrphostin_A63"                                                                                                                                                       
 [1843] "Tyrphostin_A1"                                                                                                                                                        
 [1844] "Ketanserin_Tartrate"                                                                                                                                                  
 [1845] "IMC-1C11"                                                                                                                                                             
 [1846] "DC101_Monoclonal_Antibody"                                                                                                                                            
 [1847] "Bevacizumab"                                                                                                                                                          
 [1848] "Texaphyrin"                                                                                                                                                           
 [1849] "KF-58333"                                                                                                                                                             
 [1850] "AG_1732"                                                                                                                                                              
 [1851] "Labetuzumab"                                                                                                                                                          
 [1852] "In_111_DAC"                                                                                                                                                           
 [1853] "MMI270"                                                                                                                                                               
 [1854] "TNP-40"                                                                                                                                                               
 [1855] "Prolactin_16-kD_Fragment"                                                                                                                                             
 [1856] "A-65"                                                                                                                                                                 
 [1857] "D_24851"                                                                                                                                                              
 [1858] "Alpha_V_Beta_Inhibitor"                                                                                                                                               
 [1859] "Spongistatin"                                                                                                                                                         
 [1860] "Cephalostatin"                                                                                                                                                        
 [1861] "T-1622"                                                                                                                                                               
 [1862] "BCI_Immune_Activator"                                                                                                                                                 
 [1863] "Allogenic_Glioma_Cancer_Vaccine"                                                                                                                                      
 [1864] "Neu-Sensamide"                                                                                                                                                        
 [1865] "APC_8024"                                                                                                                                                             
 [1866] "BIBH_1"                                                                                                                                                               
 [1867] "BP16_Vaccine"                                                                                                                                                         
 [1868] "Carcinoembryonic_Antigen_Peptide-1_Vaccine"                                                                                                                           
 [1869] "Monoclonal_Antibody_3A1"                                                                                                                                              
 [1870] "LGD_1550"                                                                                                                                                             
 [1871] "HPV-11_Vaccine"                                                                                                                                                       
 [1872] "GBC-590"                                                                                                                                                              
 [1873] "Tridolgosir_Hydrochloride"                                                                                                                                            
 [1874] "Votumumab"                                                                                                                                                            
 [1875] "K-RAS_Protein_Vaccine"                                                                                                                                                
 [1876] "MGV_Vaccine"                                                                                                                                                          
 [1877] "Defosfamide"                                                                                                                                                          
 [1878] "Mannomustine"                                                                                                                                                         
 [1879] "Phenamet"                                                                                                                                                             
 [1880] "Uredepa"                                                                                                                                                              
 [1881] "Monoclonal_Antibody_B1"                                                                                                                                               
 [1882] "Denopterin"                                                                                                                                                           
 [1883] "Leninan"                                                                                                                                                              
 [1884] "Polyamine_Inhibitory_Agent"                                                                                                                                           
 [1885] "Bioreductive_Agent"                                                                                                                                                   
 [1886] "Folic_Acid_Derivative"                                                                                                                                                
 [1887] "Cardioprotective_Agent"                                                                                                                                               
 [1888] "Cytoprotective_Agent"                                                                                                                                                 
 [1889] "Hepatoprotective_Agent"                                                                                                                                               
 [1890] "Uroprotective_Agent"                                                                                                                                                  
 [1891] "DNA_Methyltransferase_Inhibitor"                                                                                                                                      
 [1892] "N_N-Dibenzyl_Daunomycin"                                                                                                                                              
 [1893] "Chlorodihydropyrimidine"                                                                                                                                              
 [1894] "Inosine_5-Phosphate_Dehydrogenase_Inhibitor"                                                                                                                          
 [1895] "Inosine_Monophosphate_Dehydrogenase_Inhibitor"                                                                                                                        
 [1896] "Ornithine_Decarboxylase_Inhibitor"                                                                                                                                    
 [1897] "Protein_Kinase_C_Inhibitor"                                                                                                                                           
 [1898] "S-Adenosyl-Methionine_Decarboxylase_Inhibitor"                                                                                                                        
 [1899] "Milotane"                                                                                                                                                             
 [1900] "Gonadotropin_Releasing_Hormone_Inhibitor"                                                                                                                             
 [1901] "_131_I-Ethiodized_Oil"                                                                                                                                                
 [1902] "Receptor_Mediated_Permeabilizer_Agent"                                                                                                                                
 [1903] "Lopinavir"                                                                                                                                                            
 [1904] "Lopinavir_Ritonavir"                                                                                                                                                  
 [1905] "Telomerase_RNA_Component"                                                                                                                                             
 [1906] "Canarypox_Vectors"                                                                                                                                                    
 [1907] "Nephroprotective_Agent"                                                                                                                                               
 [1908] "GV-1301"                                                                                                                                                              
 [1909] "CyA_246"                                                                                                                                                              
 [1910] "TLC_ELL-12"                                                                                                                                                           
 [1911] "I_131_Monoclonal_Antibody_Lym-1"                                                                                                                                      
 [1912] "Vincristine_Liposomal"                                                                                                                                                
 [1913] "T-20"                                                                                                                                                                 
 [1914] "Monoclonal_Antibody_703D4"                                                                                                                                            
 [1915] "Anthrapyrazole_Antibiotic"                                                                                                                                            
 [1916] "ImmunoCyt"                                                                                                                                                            
 [1917] "Topoisomerase-IV_Inhibitor"                                                                                                                                           
 [1918] "Miscellaneous_Alkylating_Agent"                                                                                                                                       
 [1919] "Miscellaneous_Antineoplastic_Antibiotic"                                                                                                                              
 [1920] "Miscellaneous_Biologic_Response_Modifier"                                                                                                                             
 [1921] "Miscellaneous_Chemoprotective_Agent"                                                                                                                                  
 [1922] "Mustard_Agent"                                                                                                                                                        
 [1923] "DNA_Minor_Groove_Binding_Agent"                                                                                                                                       
 [1924] "Selective_Estrogen_Receptor_Down_Regulator"                                                                                                                           
 [1925] "Carbohydrate_Processing_Inhibitor"                                                                                                                                    
 [1926] "Unclassified_Chemotherapy_Agent"                                                                                                                                      
 [1927] "Golgi_Alpha-Mannosidase_II_Inhibitor"                                                                                                                                 
 [1928] "Lectin_Inhibitor"                                                                                                                                                     
 [1929] "Ozone-based_Agent"                                                                                                                                                    
 [1930] "Cell_Differentiating_Agent"                                                                                                                                           
 [1931] "Monoclonal_Antibody_16_88"                                                                                                                                            
 [1932] "Radioconjugate"                                                                                                                                                       
 [1933] "Sodium_Iodide_Radioactive"                                                                                                                                            
 [1934] "Sodium_Phosphate_Radioactive"                                                                                                                                         
 [1935] "cGMP_Phosphodiesterase_Inhibitor"                                                                                                                                     
 [1936] "Sulfur_Mustard_Compound"                                                                                                                                              
 [1937] "Mustard_Prodrug"                                                                                                                                                      
 [1938] "Gamma-Glutamylcysteine_Synthetase_Inhibitor"                                                                                                                          
 [1939] "Differentiation_Inhibitor"                                                                                                                                            
 [1940] "Bombesin_Antagonist"                                                                                                                                                  
 [1941] "Cytidine_Triphosphate_Synthetase_Inhibitor"                                                                                                                           
 [1942] "_06-Alkylguanine-DNA_Alkyltransferase_Inhibitor"                                                                                                                      
 [1943] "Cytidine_Deaminase_Inhibitor"                                                                                                                                         
 [1944] "Malignancy-Associated_Hypercalcemia_Inhibitor"                                                                                                                        
 [1945] "Glutathione_Transferase_Inhibitor"                                                                                                                                    
 [1946] "Near-Infrared_Fluorescence_Imaging_Probe"                                                                                                                             
 [1947] "Immunostimulant"                                                                                                                                                      
 [1948] "Adjuvant"                                                                                                                                                             
 [1949] "Chemo_Immunostimulant_Adjuvant"                                                                                                                                       
 [1950] "Surgical_Adjuvant"                                                                                                                                                    
 [1951] "Endothelial_Cell_Inhibitor"                                                                                                                                           
 [1952] "Endothelial-Specific_Integrin-Survival_Signaling_Inhibitor"                                                                                                           
 [1953] "Miscellaneous_Angiogenesis_Inhibitor"                                                                                                                                 
 [1954] "Miscellaneous_Antimetabolite"                                                                                                                                         
 [1955] "Kinase_Inhibitor"                                                                                                                                                     
 [1956] "Protein_Kinase_A_Inhibitor"                                                                                                                                           
 [1957] "Mitogen-Activated_Protein_Kinase_Inhibitor"                                                                                                                           
 [1958] "Ribonucleotide_Reductase_Inhibitor"                                                                                                                                   
 [1959] "Purine_Nucleoside_Phosphorylase_Inhibitor"                                                                                                                            
 [1960] "Phosphatidylinositide_3-Kinase_Inhibitor"                                                                                                                             
 [1961] "Dihydrofolate_Reductase_Inhibitor"                                                                                                                                    
 [1962] "Palmitoyl_Thioesterase_Inhibitor"                                                                                                                                     
 [1963] "Tyrosine_Hydroxylase_Inhibitor"                                                                                                                                       
 [1964] "Duocarmycin_Antibiotic"                                                                                                                                               
 [1965] "Adenosine_Deaminase_Inhibitor"                                                                                                                                        
 [1966] "Glutamine_Amidotransferase_Inhibitor"                                                                                                                                 
 [1967] "Protein_Phosphatase_Inhibitor"                                                                                                                                        
 [1968] "Proteasome_Inhibitor"                                                                                                                                                 
 [1969] "DNA_Groove_Binding_Agent"                                                                                                                                             
 [1970] "DNA_Major_Groove_Binding_Agent"                                                                                                                                       
 [1971] "DNA_Adduct_Forming_Agent"                                                                                                                                             
 [1972] "Phosphorothioate_Oligonucleotide"                                                                                                                                     
 [1973] "Mixed-Backbone_Oligonucleotide"                                                                                                                                       
 [1974] "Combination_Anti-Infective_Agent"                                                                                                                                     
 [1975] "Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor"                                                                                                           
 [1976] "Adenylosuccinate_Synthetase_Inhibitor"                                                                                                                                
 [1977] "Dihydroorotate_Dehydrogenase_Inhibitor"                                                                                                                               
 [1978] "Orotidylate_Decarboxylase_Inhibitor"                                                                                                                                  
 [1979] "Cyclobutane_Pyrimidine_Dimer"                                                                                                                                         
 [1980] "Gene_Transduction_Agent"                                                                                                                                              
 [1981] "Viral_Vector"                                                                                                                                                         
 [1982] "Non-Viral_Vector"                                                                                                                                                     
 [1983] "Gene-Vector_Complex"                                                                                                                                                  
 [1984] "Viral_Vector-Gene_Complex"                                                                                                                                            
 [1985] "Non-Viral_Vector-Gene_Complex"                                                                                                                                        
 [1986] "Transduction_Gene"                                                                                                                                                    
 [1987] "Fusion_Toxin"                                                                                                                                                         
 [1988] "Vasopressin_Antagonist"                                                                                                                                               
 [1989] "Steroidal_Estrogen"                                                                                                                                                   
 [1990] "Non-Steroidal_Estrogen"                                                                                                                                               
 [1991] "Hypothalmic_Hormone"                                                                                                                                                  
 [1992] "_3-Hydroxysteroid_Dehydrogenase_Inhibitor"                                                                                                                            
 [1993] "Cyclin-Dependent_Kinase_Inhibitor_Drug"                                                                                                                               
 [1994] "Diarylsulfonylurea_Compound"                                                                                                                                          
 [1995] "FVII_Icon"                                                                                                                                                            
 [1996] "Alkylphosphocholine_Compound"                                                                                                                                         
 [1997] "Signal_Transduction_Inhibitor"                                                                                                                                        
 [1998] "Alcohol"                                                                                                                                                              
 [1999] "Small_Interfering_RNA"                                                                                                                                                
 [2000] "TRICOM"                                                                                                                                                               
 [2001] "Monoclonal_Antibody_2C4"                                                                                                                                              
 [2002] "BAY_43-9006"                                                                                                                                                          
 [2003] "BLP25"                                                                                                                                                                
 [2004] "Antimetastatic_Agent"                                                                                                                                                 
 [2005] "Anti-Adhesion_Agent"                                                                                                                                                  
 [2006] "Nonnarcotic_Analgesic"                                                                                                                                                
 [2007] "Adjuvant_Analgesic"                                                                                                                                                   
 [2008] "Boron_Delivery_Agent"                                                                                                                                                 
 [2009] "mTOR_Inhibitor"                                                                                                                                                       
 [2010] "Acetyldinaline"                                                                                                                                                       
 [2011] "Acridine_Carboxamide"                                                                                                                                                 
 [2012] "Adenovirus_B7-1"                                                                                                                                                      
 [2013] "BCR-ABL_Peptide_Vaccine"                                                                                                                                              
 [2014] "Biomed_101"                                                                                                                                                           
 [2015] "Bispecific_Antibody_MDX447"                                                                                                                                           
 [2016] "Borocaptate_Sodium"                                                                                                                                                   
 [2017] "Capromab_Pendetide"                                                                                                                                                   
 [2018] "CC-1088"                                                                                                                                                              
 [2019] "CRL_1005"                                                                                                                                                             
 [2020] "CY-2010"                                                                                                                                                              
 [2021] "Liposomal_Daunorubicin_Citrate"                                                                                                                                       
 [2022] "Dendritic_Cell-gp100-MART-1_Antigen_Vaccine"                                                                                                                          
 [2023] "HER-2_neu_Intracellular_Domain_Peptide_Vaccine"                                                                                                                       
 [2024] "Imidazole_Mustard"                                                                                                                                                    
 [2025] "In_111_Monoclonal_Antibody_LL2"                                                                                                                                       
 [2026] "In_111_Monoclonal_Antibody_Lym-1"                                                                                                                                     
 [2027] "In_111_Monoclonal_Antibody_MN-14"                                                                                                                                     
 [2028] "Interferon_Alfa-N1"                                                                                                                                                   
 [2029] "Interferon_Beta-1B"                                                                                                                                                   
 [2030] "Interleukin-12_Gene"                                                                                                                                                  
 [2031] "I_131_Monoclonal_Antibody_TNT-1_B"                                                                                                                                    
 [2032] "Lung_Tumor_Associated_Antigen"                                                                                                                                        
 [2033] "Zosuquidar_Trihydrochloride"                                                                                                                                          
 [2034] "Lycopene"                                                                                                                                                             
 [2035] "Monoclonal_Antibody_4B5_Anti-Idiotype_Vaccine"                                                                                                                        
 [2036] "Apolizumab"                                                                                                                                                           
 [2037] "Monoclonal_Antibody_HuM291"                                                                                                                                           
 [2038] "Monoclonal_Antibody_M-T412"                                                                                                                                           
 [2039] "MS-209"                                                                                                                                                               
 [2040] "MUC-1_KLH_Vaccine"                                                                                                                                                    
 [2041] "Phenethyl_Isothiocyanate"                                                                                                                                             
 [2042] "PNU_166148"                                                                                                                                                           
 [2043] "PR1_Leukemia_Peptide_Vaccine"                                                                                                                                         
 [2044] "PSA_RNA-Pulsed_Dendritic_Cell_Vaccine"                                                                                                                                
 [2045] "Recombinant_Vaccinia-B7_1_Vaccine"                                                                                                                                    
 [2046] "Retrovirus_Vector_LN"                                                                                                                                                 
 [2047] "RevM10_gene-polAS_gene"                                                                                                                                               
 [2048] "AS02A"                                                                                                                                                                
 [2049] "TG4010"                                                                                                                                                               
 [2050] "Triapine"                                                                                                                                                             
 [2051] "Tumor_necrosis_factor_CET"                                                                                                                                            
 [2052] "Tumor_Necrosis_Factor_Knoll"                                                                                                                                          
 [2053] "Tumor_necrosis_factor_GEN"                                                                                                                                            
 [2054] "Tariquidar"                                                                                                                                                           
 [2055] "Y_90_Monoclonal_Antibody_Lym-1"                                                                                                                                       
 [2056] "Y_90_Monoclonal_Antibody_M195"                                                                                                                                        
 [2057] "Y_90_Monoclonal_Antibody_MN-14"                                                                                                                                       
 [2058] "_10-Propargyl-10-Deazaaminopterin"                                                                                                                                    
 [2059] "Therapeutic_Platelet_Factor_4"                                                                                                                                        
 [2060] "Chemotherapeutic_Topical_Agent"                                                                                                                                       
 [2061] "DNA_Repair_Enzyme_Topical_Agent"                                                                                                                                      
 [2062] "Amidophosphoribosyltransferase_Inhibitor"                                                                                                                             
 [2063] "Estrogen_Sulfotransferase_Inhibitor"                                                                                                                                  
 [2064] "Therapeutic_Delta_Chemokine"                                                                                                                                          
 [2065] "Therapeutic_Fractalkine"                                                                                                                                              
 [2066] "Angiotropin_Recombinant"                                                                                                                                              
 [2067] "Therapeutic_Neurotrophic_Factor"                                                                                                                                      
 [2068] "Therapeutic_Neuropoietic_Cytokines"                                                                                                                                   
 [2069] "Therapeutic_Heparin-Binding_Neurotrophic_Factor"                                                                                                                      
 [2070] "Recombinant_IGF-I"                                                                                                                                                    
 [2071] "Recombinant_IGF-II"                                                                                                                                                   
 [2072] "Adrenal_Hormone"                                                                                                                                                      
 [2073] "Therapeutic_Dehydroepiandrosterone"                                                                                                                                   
 [2074] "Recombinant_Thymopoietin"                                                                                                                                             
 [2075] "Melatonin"                                                                                                                                                            
 [2076] "Glucagon"                                                                                                                                                             
 [2077] "Corticotropin_Releasing_Hormone"                                                                                                                                      
 [2078] "Gonadotrophin_Releasing_Hormone"                                                                                                                                      
 [2079] "Insulin"                                                                                                                                                              
 [2080] "Gastrin_Releasing_Peptide"                                                                                                                                            
 [2081] "Gonadotropin"                                                                                                                                                         
 [2082] "Human_Menopausal_Gonadotropin"                                                                                                                                        
 [2083] "Human_Chorionic_Gonadotropin"                                                                                                                                         
 [2084] "Inhibin"                                                                                                                                                              
 [2085] "Inhibin-A"                                                                                                                                                            
 [2086] "Inhibin-B"                                                                                                                                                            
 [2087] "Prothymosin_Alpha"                                                                                                                                                    
 [2088] "Thyroid_Stimulating_Hormone"                                                                                                                                          
 [2089] "Calcitonin"                                                                                                                                                           
 [2090] "Adrenocorticotropic_Hormone"                                                                                                                                          
 [2091] "Oxytocin"                                                                                                                                                             
 [2092] "Thymosin"                                                                                                                                                             
 [2093] "Vasopressin"                                                                                                                                                          
 [2094] "Follicle_Stimulating_Hormone"                                                                                                                                         
 [2095] "Luteinizing_Hormone"                                                                                                                                                  
 [2096] "Growth_Hormone"                                                                                                                                                       
 [2097] "Steroid_Hormone"                                                                                                                                                      
 [2098] "Cortisol"                                                                                                                                                             
 [2099] "Cortisone"                                                                                                                                                            
 [2100] "Epinephrine"                                                                                                                                                          
 [2101] "Estrogen"                                                                                                                                                             
 [2102] "Estrone"                                                                                                                                                              
 [2103] "Estradiol"                                                                                                                                                            
 [2104] "Progestagen"                                                                                                                                                          
 [2105] "Progesterone"                                                                                                                                                         
 [2106] "Androgen"                                                                                                                                                             
 [2107] "Testosterone"                                                                                                                                                         
 [2108] "Androstenedione"                                                                                                                                                      
 [2109] "Testolactone"                                                                                                                                                         
 [2110] "Thyroxine"                                                                                                                                                            
 [2111] "Triiodothyronine"                                                                                                                                                     
 [2112] "Thyroglobulin"                                                                                                                                                        
 [2113] "WT1-Ricin_A_Immunotoxin"                                                                                                                                              
 [2114] "Ad5CMV"                                                                                                                                                               
 [2115] "Adenovirus_Agent"                                                                                                                                                     
 [2116] "Improsulfan"                                                                                                                                                          
 [2117] "Glutaminase-Asparaginase"                                                                                                                                             
 [2118] "PEG-Glutaminase-Asparaginase"                                                                                                                                         
 [2119] "Bleomycin_Antibiotic"                                                                                                                                                 
 [2120] "ALVAC"                                                                                                                                                                
 [2121] "Vaccinia_Vaccine"                                                                                                                                                     
 [2122] "Anti-Gastrin_Therapeutic_Vaccine"                                                                                                                                     
 [2123] "Hormone"                                                                                                                                                              
 [2124] "Miscellaneous_Adjuvant"                                                                                                                                               
 [2125] "Dietary_Lipid"                                                                                                                                                        
 [2126] "Shark_Cartilage"                                                                                                                                                      
 [2127] "_5_Alpha-Reductase_Inhibitor"                                                                                                                                         
 [2128] "Teroxirone"                                                                                                                                                           
 [2129] "Norepinephrine"                                                                                                                                                       
 [2130] "Corticosteroid"                                                                                                                                                       
 [2131] "Glucocorticoid"                                                                                                                                                       
 [2132] "Mineralocorticoid"                                                                                                                                                    
 [2133] "Therapeutic_Beta_Thromboglobulin"                                                                                                                                     
 [2134] "Recombinant_Fibroblast_Growth_Factor_7"                                                                                                                               
 [2135] "Niacinamide"                                                                                                                                                          
 [2136] "Cefotaxime_Sodium"                                                                                                                                                    
 [2137] "HB2-Saporin_Immunotoxin"                                                                                                                                              
 [2138] "Anti-CD19_Immunotoxins"                                                                                                                                               
 [2139] "B43-PAP_Immunotoxin"                                                                                                                                                  
 [2140] "B43_Immunotoxin"                                                                                                                                                      
 [2141] "Anti-CD33_Immunotoxin"                                                                                                                                                
 [2142] "Di-dgA-RFB4_Immunotoxin"                                                                                                                                              
 [2143] "IgG-RFB4-SMPT-dgA_Immunotoxin"                                                                                                                                        
 [2144] "Raf_Kinase_Inhibitor"                                                                                                                                                 
 [2145] "Sodium_Butyrate"                                                                                                                                                      
 [2146] "Imipenem-Cilastatin_Sodium"                                                                                                                                           
 [2147] "BCG_Cell_Wall_Skeleton"                                                                                                                                               
 [2148] "Combid"                                                                                                                                                               
 [2149] "Tumor_Cell_Derivative_Vaccine"                                                                                                                                        
 [2150] "Recombinant_Soluble_Human_CD4_Protein"                                                                                                                                
 [2151] "Flurocitabine"                                                                                                                                                        
 [2152] "Camptothecin_Sodium"                                                                                                                                                  
 [2153] "Freunds_Adjuvant"                                                                                                                                                     
 [2154] "Pituitary_Agent"                                                                                                                                                      
 [2155] "Monoclonal_Antibody_R24"                                                                                                                                              
 [2156] "Ovine_Submaxillary_Mucin"                                                                                                                                             
 [2157] "Hyperbaric_Oxygen"                                                                                                                                                    
 [2158] "Methylmercaptopurine_Riboside"                                                                                                                                        
 [2159] "PALA_Disodium"                                                                                                                                                        
 [2160] "Thiazolidine_Carboxylic_Acid"                                                                                                                                         
 [2161] "Anti-Adrenal"                                                                                                                                                         
 [2162] "Analgesic_and_Antipyretic"                                                                                                                                            
 [2163] "I_131_Antiferritin_Immunoglobulin"                                                                                                                                    
 [2164] "Monoclonal_Antibody_T101"                                                                                                                                             
 [2165] "Ricin_Immunoconjugate"                                                                                                                                                
 [2166] "Anabolic_Steroid"                                                                                                                                                     
 [2167] "Substituted_Urea"                                                                                                                                                     
 [2168] "Podophyllin"                                                                                                                                                          
 [2169] "Aminoglycoside_Antibiotic"                                                                                                                                            
 [2170] "Adrenal_Agent"                                                                                                                                                        
 [2171] "Pefloxacin_Penicillin-V"                                                                                                                                              
 [2172] "M-Azidopyrimethamine"                                                                                                                                                 
 [2173] "CB10-277"                                                                                                                                                             
 [2174] "Monoclonal_Antibody_14G2A"                                                                                                                                            
 [2175] "Methionyl-Interferon-Consensus"                                                                                                                                       
 [2176] "Monoclonal_Antibody_3F8"                                                                                                                                              
 [2177] "Ethylchlorformate"                                                                                                                                                    
 [2178] "Monoclonal_Antibody_L6"                                                                                                                                               
 [2179] "Interleukin-2_Liposome"                                                                                                                                               
 [2180] "TP40_Immunotoxin"                                                                                                                                                     
 [2181] "Muramyl_Tripeptide_Phosphatidylethanolamine_Liposome"                                                                                                                 
 [2182] "GM2-KLH_Vaccine"                                                                                                                                                      
 [2183] "L-Leucyl-L-Leucine_Methyl_Ester"                                                                                                                                      
 [2184] "Vinfosiltine"                                                                                                                                                         
 [2185] "Triacetyluridine"                                                                                                                                                     
 [2186] "Anti-B4_Blocked_Ricin_Immunotoxin"                                                                                                                                    
 [2187] "Etanercept"                                                                                                                                                           
 [2188] "Monoclonal_Antibody_BEC2"                                                                                                                                             
 [2189] "DAB389_Epidermal_Growth_Factor"                                                                                                                                       
 [2190] "Tyrosinase-KLH"                                                                                                                                                       
 [2191] "Theramide"                                                                                                                                                            
 [2192] "gp100_Antigen"                                                                                                                                                        
 [2193] "Monoclonal_Antibody_LL2"                                                                                                                                              
 [2194] "Liposomal_Cytarabine"                                                                                                                                                 
 [2195] "Daflon_500"                                                                                                                                                           
 [2196] "Antiseborrheic_Agent"                                                                                                                                                 
 [2197] "Radium"                                                                                                                                                               
 [2198] "Gold"                                                                                                                                                                 
 [2199] "Industrial_Product"                                                                                                                                                   
 [2200] "Miscellaneous_Antibiotic"                                                                                                                                             
 [2201] "Therapeutic_Hematopoietic_Growth_Factor"                                                                                                                              
 [2202] "I_131_Liothyronine"                                                                                                                                                   
 [2203] "PADRE_965_10"                                                                                                                                                         
 [2204] "Tretinoin_Liposome"                                                                                                                                                   
 [2205] "Bispecific_Antibody_2B1"                                                                                                                                              
 [2206] "GD2-KLH_Vaccine"                                                                                                                                                      
 [2207] "Tyrosinase_Peptide"                                                                                                                                                   
 [2208] "Octreotide_Pamoate"                                                                                                                                                   
 [2209] "Human_Papillomavirus_TA_Vaccine"                                                                                                                                      
 [2210] "Rasburicase"                                                                                                                                                          
 [2211] "Boronophenylalanine-Fructose_Complex"                                                                                                                                 
 [2212] "gp209-2M_Antigen"                                                                                                                                                     
 [2213] "MUC-1_Antigen"                                                                                                                                                        
 [2214] "T4N5_Liposomal_Lotion"                                                                                                                                                
 [2215] "Monoclonal_Antibody_Me1-14_F_ab_2"                                                                                                                                    
 [2216] "Monoclonal_Antibody_A33"                                                                                                                                              
 [2217] "CEP-2563_Dihydrochloride"                                                                                                                                             
 [2218] "Diethylhomospermine"                                                                                                                                                  
 [2219] "Therapeutic_Leukocyte_Interleukin"                                                                                                                                    
 [2220] "Carcinoembryonic_Antigen_Peptide_1"                                                                                                                                   
 [2221] "Potassium_Oxonate"                                                                                                                                                    
 [2222] "Chlorodihydroxypyridine"                                                                                                                                              
 [2223] "Monoclonal_Antibody_MX35_F_ab_2"                                                                                                                                      
 [2224] "Bovine_Cartilage"                                                                                                                                                     
 [2225] "HPV-16_E7_12-20_Peptide_Vaccine"                                                                                                                                      
 [2226] "E1A_Lipid_Complex"                                                                                                                                                    
 [2227] "Tc_99m_Monoclonal_Antibody_170"                                                                                                                                       
 [2228] "_5-Fluoropyrimidinone"                                                                                                                                                
 [2229] "Recombinant_Adenovirus-p53"                                                                                                                                           
 [2230] "Monoclonal_Antibody_3H1_Anti-Idiotype_Vaccine"                                                                                                                        
 [2231] "DetoxPC"                                                                                                                                                              
 [2232] "Dendritic_Cell-MART-1_Peptide_Vaccine"                                                                                                                                
 [2233] "Dendritic_Cell-G9-209-2M_Peptide_Vaccine"                                                                                                                             
 [2234] "PA-1-STK_Ovarian_Carcinoma_Vaccine"                                                                                                                                   
 [2235] "Sargramostim_Plasmid_DNA_Sarcoma_Vaccine"                                                                                                                             
 [2236] "Sargramostim_Plasmid_DNA_Melanoma_Vaccine"                                                                                                                            
 [2237] "I_131_Monoclonal_Antibody_3F8"                                                                                                                                        
 [2238] "Autologous_gp96_Heat_Shock_Protein_Peptide_Complex_Vaccine"                                                                                                           
 [2239] "Vaccinia_Prostate_Specific_Antigen_Vaccine"                                                                                                                           
 [2240] "Environmental_Tobacco_Smoke"                                                                                                                                          
 [2241] "Anti-CD7_Immunotoxin"                                                                                                                                                 
 [2242] "Monoclonal_Antibody_A1G4_Anti-Idiotype_Vaccine"                                                                                                                       
 [2243] "IL-2_Plasmid_DNA-Lipid_Complex"                                                                                                                                       
 [2244] "Ras_Peptide_Cancer_Vaccine"                                                                                                                                           
 [2245] "Carcinoembryonic_Antigen_RNA-pulsed_DC_Cancer_Vaccine"                                                                                                                
 [2246] "I_124_Monoclonal_Antibody_A33"                                                                                                                                        
 [2247] "Interleukin-4_pe38kdel_Immunotoxin"                                                                                                                                   
 [2248] "Canarypox-hIL-12_Melanoma_Vaccine"                                                                                                                                    
 [2249] "Timcodar_Dimesylate"                                                                                                                                                  
 [2250] "I_131_Monoclonal_Antibody_Anti-B1"                                                                                                                                    
 [2251] "Sargramostim_Plasmid_DNA_Pancreatic_Tumor_Cell_Vaccine"                                                                                                               
 [2252] "Monoclonal_Antibody_11D10"                                                                                                                                            
 [2253] "Monoclonal_Antibody_A27_15"                                                                                                                                           
 [2254] "Monoclonal_Antibody_E2_3"                                                                                                                                             
 [2255] "I_131_Monoclonal_Antibody_G-250"                                                                                                                                      
 [2256] "Sn_117m_Pentetic_Acid"                                                                                                                                                
 [2257] "Adenovirus_p53"                                                                                                                                                       
 [2258] "Aminocamptothecin_Colloidal_Dispersion"                                                                                                                               
 [2259] "ERB-38_Immunotoxin"                                                                                                                                                   
 [2260] "COL-3"                                                                                                                                                                
 [2261] "Recombinant_Human_Keratinocyte_Growth_Factor"                                                                                                                         
 [2262] "Anti-CEA_Antibody"                                                                                                                                                    
 [2263] "c-FOS_Antisense"                                                                                                                                                      
 [2264] "Autologous_Tumor_Cells"                                                                                                                                               
 [2265] "Chemoprotective_Agent"                                                                                                                                                
 [2266] "Arzoxifene_Hydrochloride"                                                                                                                                             
 [2267] "NR-LU-10_Antigen"                                                                                                                                                     
 [2268] "Radioactive_Iodine"                                                                                                                                                   
 [2269] "Retroviral_Vector"                                                                                                                                                    
 [2270] "CD80_Breast_Cancer_Vaccine"                                                                                                                                           
 [2271] "MUC-2-KLH_Vaccine"                                                                                                                                                    
 [2272] "Peptide_946_Melanoma_Vaccine"                                                                                                                                         
 [2273] "Peptide_946-Tetanus_Peptide_Conjugate_Melanoma_Vaccine"                                                                                                               
 [2274] "Tetanus_Peptide_Melanoma_Vaccine"                                                                                                                                     
 [2275] "Peptide_946-Tetanus_Peptide_Conjugate_Melanoma_Vaccine-QS21"                                                                                                          
 [2276] "Monoclonal_Antibody_3622W94"                                                                                                                                          
 [2277] "Ad5CMV-p53_Gene"                                                                                                                                                      
 [2278] "LMB-9_Immunotoxin"                                                                                                                                                    
 [2279] "Dendritic_Cell_CEA_Peptide_Vaccine"                                                                                                                                   
 [2280] "Tn_c_KLH_Conjugate_Vaccine"                                                                                                                                           
 [2281] "Promegapoietin"                                                                                                                                                       
 [2282] "Monoclonal_Antibody_muJ591"                                                                                                                                           
 [2283] "I_131_Monoclonal_Antibody_A33"                                                                                                                                        
 [2284] "Dinitrophenyl"                                                                                                                                                        
 [2285] "Beta_Endorphin"                                                                                                                                                       
 [2286] "Tracer"                                                                                                                                                               
 [2287] "Cetrorelix"                                                                                                                                                           
 [2288] "Miscellaneous_Antiviral_Agent"                                                                                                                                        
 [2289] "Miscellaneous_Hormone_Agent"                                                                                                                                          
 [2290] "Methaqualone_Hydrochloride"                                                                                                                                           
 [2291] "ALVAC-hB7_1"                                                                                                                                                          
 [2292] "Interleukin-1_Receptor_Antagonist"                                                                                                                                    
 [2293] "Polifeprosan_20_with_Carmustine_Implant"                                                                                                                              
 [2294] "I_131_Monoclonal_Antibody_81C6"                                                                                                                                       
 [2295] "I_123_Monoclonal_Antibody_81C6"                                                                                                                                       
 [2296] "At_211_Monoclonal_Antibody_81C6"                                                                                                                                      
 [2297] "Pegylated_Interferon_Alfa"                                                                                                                                            
 [2298] "Von_Hippel-Lindau_Peptide_Vaccine"                                                                                                                                    
 [2299] "Adenovirus_5-CD40-L_Vector"                                                                                                                                           
 [2300] "GPX-100"                                                                                                                                                              
 [2301] "In_111-DOTA-Biotin"                                                                                                                                                   
 [2302] "Monoclonal_Antibody_Anti-VEGF"                                                                                                                                        
 [2303] "PSA_Prostate_Cancer_Vaccine"                                                                                                                                          
 [2304] "Patent_Blue_V_Dye"                                                                                                                                                    
 [2305] "LMB-1_Immunotoxin"                                                                                                                                                    
 [2306] "Antineoplaston_Agent"                                                                                                                                                 
 [2307] "STn-KLH_plus_Detox_Vaccine"                                                                                                                                           
 [2308] "Cisplatin_Liposomal"                                                                                                                                                  
 [2309] "Combretastatin_A4_Phosphate"                                                                                                                                          
 [2310] "Dimethylxanthenone_Acetic_Acid"                                                                                                                                       
 [2311] "Monoclonal_Antibody_HeFi-1"                                                                                                                                           
 [2312] "In_111_Folic_Acid"                                                                                                                                                    
 [2313] "Ro_31-7453"                                                                                                                                                           
 [2314] "Dextromethorphan_Acetic_Acid"                                                                                                                                         
 [2315] "Hu14_18-Interleukin-2_Fusion_Protein"                                                                                                                                 
 [2316] "Recombinant_Vaccinia_DF3_MUC1_Vaccine"                                                                                                                                
 [2317] "IDEC-In2B8"                                                                                                                                                           
 [2318] "AFP_Gene_Hepatocellular_Carcinoma_Vaccine"                                                                                                                            
 [2319] "LMB-2_Immunotoxin"                                                                                                                                                    
 [2320] "Monoclonal_Antibody_F19"                                                                                                                                              
 [2321] "I_131_Monoclonal_Antibody_F19"                                                                                                                                        
 [2322] "Geldanamycin_Analogue"                                                                                                                                                
 [2323] "Melanoma_Vaccine"                                                                                                                                                     
 [2324] "GI14721"                                                                                                                                                              
 [2325] "Barium_Solution"                                                                                                                                                      
 [2326] "KSA-KLH_Conjugate_Vaccine"                                                                                                                                            
 [2327] "Fowlpox_Virus_Vaccine"                                                                                                                                                
 [2328] "DTGM_Fusion_Protein"                                                                                                                                                  
 [2329] "Monoclonal_Antibody_CD19"                                                                                                                                             
 [2330] "Monoclonal_Antibody_CD20"                                                                                                                                             
 [2331] "GVAX_Prostate_Cancer_Vaccine"                                                                                                                                         
 [2332] "Anhydrovinblastine"                                                                                                                                                   
 [2333] "I_131_Monoclonal_Antibody_BC8"                                                                                                                                        
 [2334] "Thompson-Friedenreich_Antigen"                                                                                                                                        
 [2335] "TF_c_KLH_Conjugate_Vaccine"                                                                                                                                           
 [2336] "MG_98"                                                                                                                                                                
 [2337] "Vaccinia-Tyrosinase_Vaccine"                                                                                                                                          
 [2338] "Y_90_Monoclonal_Antibody_m170"                                                                                                                                        
 [2339] "In_111_Monoclonal_Antibody_M170"                                                                                                                                      
 [2340] "Autologous_Expanded_Mesenchymal_Stem_Cells"                                                                                                                           
 [2341] "Serum_Hyaluronic_Acid"                                                                                                                                                
 [2342] "Canarypox_Antigen"                                                                                                                                                    
 [2343] "HER-2_neu_Peptide_Vaccine"                                                                                                                                            
 [2344] "_2IT-BAD_Monoclonal_Antibody_170"                                                                                                                                     
 [2345] "BIBX_1382"                                                                                                                                                            
 [2346] "Mutant_p53_Peptide_Pulsed_Dendritic_Cell_Vaccine"                                                                                                                     
 [2347] "Y_90_Monoclonal_Antibody_HMFG1"                                                                                                                                       
 [2348] "Vaccine-Sensitized_Draining_Lymph_Node_Cells"                                                                                                                         
 [2349] "Tositumomab"                                                                                                                                                          
 [2350] "B43-Genistein_Immunoconjugate"                                                                                                                                        
 [2351] "Adenovirus_RSV-TK"                                                                                                                                                    
 [2352] "OVA_BiP_Peptide"                                                                                                                                                      
 [2353] "Monoclonal_Antibody_Hu3S193"                                                                                                                                          
 [2354] "Prostatic_Acid_Phosphatase-Sargramostim_Fusion_Protein"                                                                                                               
 [2355] "Interleukin-2_Gene"                                                                                                                                                   
 [2356] "Palladium_103"                                                                                                                                                        
 [2357] "CP-609_754"                                                                                                                                                           
 [2358] "In_111_Monoclonal_Antibody_Hu3S193"                                                                                                                                   
 [2359] "pM-81_Monoclonal_Antibody"                                                                                                                                            
 [2360] "Vaccine_Adjuvant"                                                                                                                                                     
 [2361] "PROST_30_Monoclonal_Antibody"                                                                                                                                         
 [2362] "VNP20009"                                                                                                                                                             
 [2363] "Tc_99m_Human_Serum_Albumin_Colloid"                                                                                                                                   
 [2364] "Glufanide_Disodium"                                                                                                                                                   
 [2365] "Therapeutic_Macrophage_Inflammatory_Protein-2_Alpha"                                                                                                                  
 [2366] "Therapeutic_Macrophage_Inflammatory_Protein-2_Beta"                                                                                                                   
 [2367] "T-Cell_Receptor-Rearrangement_Excision_DNA_Circles"                                                                                                                   
 [2368] "Food_Oil"                                                                                                                                                             
 [2369] "Omega-6_Fatty_Acid"                                                                                                                                                   
 [2370] "Allopurinol_Sodium"                                                                                                                                                   
 [2371] "Thyroid_Extract"                                                                                                                                                      
 [2372] "Detox-B_Adjuvant"                                                                                                                                                     
 [2373] "Monoclonal_Antibody_CC49"                                                                                                                                             
 [2374] "Hydrocortisone_Placebo"                                                                                                                                               
 [2375] "Human_Papillomavirus_16_E7_Peptide-Padre_965_10"                                                                                                                      
 [2376] "Arginine_Butyrate"                                                                                                                                                    
 [2377] "Tocladesine"                                                                                                                                                          
 [2378] "Murine_Monoclonal_Antibody_2B8"                                                                                                                                       
 [2379] "Technetium_Tc_99m_Epratuzumab"                                                                                                                                        
 [2380] "Fat_Emulsion"                                                                                                                                                         
 [2381] "Dendritic_Cell-Recombinant_Prostate-Specific_Membrane_Antigen_Vaccine"                                                                                                
 [2382] "Low_Molecular_Weight_Heparin"                                                                                                                                         
 [2383] "In_111_Ibritumomab_Tiuxetan"                                                                                                                                          
 [2384] "SB_AS-2"                                                                                                                                                              
 [2385] "Liothyronine_Sodium"                                                                                                                                                  
 [2386] "Y_90_Humanized_Monoclonal_Antibody_LL2"                                                                                                                               
 [2387] "Rosiglitazone"                                                                                                                                                        
 [2388] "Epothilone_B_Analogue"                                                                                                                                                
 [2389] "Beriplast_P"                                                                                                                                                          
 [2390] "Psoralen"                                                                                                                                                             
 [2391] "Progenipoietin"                                                                                                                                                       
 [2392] "Gadopentetate_Dimeglumine"                                                                                                                                            
 [2393] "Hypericum_Perforatum"                                                                                                                                                 
 [2394] "Anti-Idiotype_Vaccine"                                                                                                                                                
 [2395] "Benzaldehyde"                                                                                                                                                         
 [2396] "Monoclonal_Antibody_M195"                                                                                                                                             
 [2397] "HER-2_neu_Intracellular_Domain_Protein"                                                                                                                               
 [2398] "Autologous_Dendritic_Cells"                                                                                                                                           
 [2399] "Candida_Albicans_Skin_Test_Reagent"                                                                                                                                   
 [2400] "MAGE-12_Peptide_Vaccine"                                                                                                                                              
 [2401] "Y_90_Monoclonal_Antibody_CC49"                                                                                                                                        
 [2402] "Lutetium_Lu_177_Monoclonal_Antibody_CC49"                                                                                                                             
 [2403] "Interleukin-13_PE38QQR_Immunotoxin"                                                                                                                                   
 [2404] "Yttrium_Y_90_Daclizumab"                                                                                                                                              
 [2405] "Yttrium_Y_90_SMT_487"                                                                                                                                                 
 [2406] "Carmustine_in_Ethanol"                                                                                                                                                
 [2407] "Donepezil"                                                                                                                                                            
 [2408] "Iodine_I_131_Monoclonal_Antibody_muJ591"                                                                                                                              
 [2409] "Beta_Alethine"                                                                                                                                                        
 [2410] "Monoclonal_Antibody_11D10_Anti-Idiotype_Vaccine"                                                                                                                      
 [2411] "Yttrium_Y_90_Monoclonal_Antibody_BrE-3"                                                                                                                               
 [2412] "In_111_Monoclonal_Antibody_BrE-3"                                                                                                                                     
 [2413] "SS1_dsFv-PE38_Immunotoxin"                                                                                                                                            
 [2414] "Monoclonal_Antibody_M170"                                                                                                                                             
 [2415] "Monoclonal_Antibody_Mono-dgA-RFB4"                                                                                                                                    
 [2416] "ESO-1_Peptide_Vaccine"                                                                                                                                                
 [2417] "INS316"                                                                                                                                                               
 [2418] "Yttrium_Y_90_Monoclonal_Antibody_B3"                                                                                                                                  
 [2419] "In_111_Monoclonal_Antibody_B3"                                                                                                                                        
 [2420] "SMT-487"                                                                                                                                                              
 [2421] "EGFR_Antisense_DNA"                                                                                                                                                   
 [2422] "Benzoylphenylurea"                                                                                                                                                    
 [2423] "Vaccinia-CEA-TRICOM_Vaccine"                                                                                                                                          
 [2424] "Fowlpox-CEA-TRICOM_Vaccine"                                                                                                                                           
 [2425] "Monoclonal_Antibody_ABX-CBL"                                                                                                                                          
 [2426] "CEA_571-579_Peptide"                                                                                                                                                  
 [2427] "NV1020"                                                                                                                                                               
 [2428] "Bispecific_Antibody_4G7xH22"                                                                                                                                          
 [2429] "Palivizumab"                                                                                                                                                          
 [2430] "Huang_Lian"                                                                                                                                                           
 [2431] "GPI-0100"                                                                                                                                                             
 [2432] "MUC-2-Globo_H-KLH_Conjugate_Vaccine"                                                                                                                                  
 [2433] "Valganciclovir"                                                                                                                                                       
 [2434] "KSA-Interleukin-2_Fusion_Protein"                                                                                                                                     
 [2435] "Paclitaxel_Liposome"                                                                                                                                                  
 [2436] "Annamycin"                                                                                                                                                            
 [2437] "AG2037"                                                                                                                                                               
 [2438] "Digitoxin"                                                                                                                                                            
 [2439] "Pirfenidone"                                                                                                                                                          
 [2440] "HPPH"                                                                                                                                                                 
 [2441] "MVF-HER-2_628-647-CRL_1005_Vaccine"                                                                                                                                   
 [2442] "MOv-gamma_Chimeric_Receptor_Gene"                                                                                                                                     
 [2443] "Taurolidine"                                                                                                                                                          
 [2444] "Telomerase_540-548_Peptide_Vaccine"                                                                                                                                   
 [2445] "TLK286"                                                                                                                                                               
 [2446] "Phenoxodiol"                                                                                                                                                          
 [2447] "Trivalent_Influenza_Vaccine"                                                                                                                                          
 [2448] "Doxorubicin-Magnetic_Targeted_Carrier_Complex"                                                                                                                        
 [2449] "Doxercalciferol"                                                                                                                                                      
 [2450] "Tyrosinase-Related_Protein-2"                                                                                                                                         
 [2451] "Methyl-5-Aminolevulinate"                                                                                                                                             
 [2452] "Monoclonal_Antibody_105AD7_Anti-idiotype_Vaccine"                                                                                                                     
 [2453] "DHA-Paclitaxel"                                                                                                                                                       
 [2454] "Synchrotope_TA2M_Plasmid_DNA_Vaccine"                                                                                                                                 
 [2455] "Silicon_Phthalocyanine_4"                                                                                                                                             
 [2456] "Monoclonal_Antibody_huJ591"                                                                                                                                           
 [2457] "VNP40101M"                                                                                                                                                            
 [2458] "Anti-Cytotoxic_T-Lymphocyte-Associated_Antigen-4_Monoclonal_Antibody"                                                                                                 
 [2459] "Iseganan_Hydrochloride"                                                                                                                                               
 [2460] "Halofuginone_Hydrobromide"                                                                                                                                            
 [2461] "NY-ESO-1_Peptide_Vaccine"                                                                                                                                             
 [2462] "Anti-CD3_x_anti-HER-2-neu_Bispecific_Monoclonal_Antibody"                                                                                                             
 [2463] "Monoclonal_Antibody_CAL"                                                                                                                                              
 [2464] "Tetanus_Toxoid"                                                                                                                                                       
 [2465] "Herba_Scutellariae_Barbatae"                                                                                                                                          
 [2466] "XK469"                                                                                                                                                                
 [2467] "Chinese_Herbs"                                                                                                                                                        
 [2468] "Fibrin_Sealant"                                                                                                                                                       
 [2469] "Edotecarin"                                                                                                                                                           
 [2470] "Recombinant_Fowlpox-B7_1_Vaccine"                                                                                                                                     
 [2471] "Fowlpox-TRICOM_Vaccine"                                                                                                                                               
 [2472] "CC-5013"                                                                                                                                                              
 [2473] "Monoclonal_Antibody_Mik-Beta-1"                                                                                                                                       
 [2474] "CI-1040"                                                                                                                                                              
 [2475] "S-3304"                                                                                                                                                               
 [2476] "Epothilone_D"                                                                                                                                                         
 [2477] "Clopidogrel_Bisulfate"                                                                                                                                                
 [2478] "Vaccinia-GM-CSF_Vaccine"                                                                                                                                              
 [2479] "Fowlpox-PSA_Vaccine"                                                                                                                                                  
 [2480] "G207"                                                                                                                                                                 
 [2481] "Magnetic-Targeted_Carriers"                                                                                                                                           
 [2482] "Beta-Glucan"                                                                                                                                                          
 [2483] "ABT-751"                                                                                                                                                              
 [2484] "NA17_A2_Antigen"                                                                                                                                                      
 [2485] "MAGE-10_A2"                                                                                                                                                           
 [2486] "VEGF_Trap"                                                                                                                                                            
 [2487] "Monoclonal_Antibody_D6_12"                                                                                                                                            
 [2488] "Monoclonal_Antibody_C-58"                                                                                                                                             
 [2489] "Vaccinia-TRICOM_Vaccine"                                                                                                                                              
 [2490] "Fowlpox-Sargramostim"                                                                                                                                                 
 [2491] "Visilizumab"                                                                                                                                                          
 [2492] "ABI-007"                                                                                                                                                              
 [2493] "IH636_Grape_Seed_Proanthocyanidin_Extract"                                                                                                                            
 [2494] "Sho-Saiko-To"                                                                                                                                                         
 [2495] "Ginger"                                                                                                                                                               
 [2496] "Glycinamide_Ribonucleotide_Formyltransferase_Inhibitor"                                                                                                               
 [2497] "Erlotinib"                                                                                                                                                            
 [2498] "Green_Tea_Extract"                                                                                                                                                    
 [2499] "Epoetin_Alfa"                                                                                                                                                         
 [2500] "I_131_Lipiodol"                                                                                                                                                       
 [2501] "Iodine_I_131_Monoclonal_Antibody_CC49-deltaCH2"                                                                                                                       
 [2502] "Monoclonal_Antibody_CC49-delta_CH2"                                                                                                                                   
 [2503] "Enzyme_Catalyzed_Therapeutic_Activation_Agent"                                                                                                                        
 [2504] "Human_Thymosin-Fraction_5"                                                                                                                                            
 [2505] "Therapeutic_Immune_Globulin"                                                                                                                                          
 [2506] "Vincristine_Sulfate_Liposomes"                                                                                                                                        
 [2507] "Mistletoe_Extract"                                                                                                                                                    
 [2508] "Fixative_Stain"                                                                                                                                                       
 [2509] "Tag"                                                                                                                                                                  
 [2510] "Anthrapyrazole"                                                                                                                                                       
 [2511] "DHEA_Mustard"                                                                                                                                                         
 [2512] "Curcumin_C3_Complex"                                                                                                                                                  
 [2513] "Anti-idiotype_MUC-1_Monoclonal_Antibody"                                                                                                                              
 [2514] "CEA_RNA-pulsed_Autologous_Human_Cultured_Dendritic_Cells"                                                                                                             
 [2515] "Combretastatin_A-4"                                                                                                                                                   
 [2516] "Monoclonal_Antibody_E7_6_3"                                                                                                                                           
 [2517] "EKB-569"                                                                                                                                                              
 [2518] "EMD_55900"                                                                                                                                                            
 [2519] "FJ5002"                                                                                                                                                               
 [2520] "Monoclonal_Antibody_GW2016"                                                                                                                                           
 [2521] "HER_Peptides"                                                                                                                                                         
 [2522] "Poly_Microsphere_Encapsulated_HER2_neu_Oral_Vaccine"                                                                                                                  
 [2523] "HuMV833"                                                                                                                                                              
 [2524] "Monoclonal_Antibody_ICR62"                                                                                                                                            
 [2525] "ISIS_5132"                                                                                                                                                            
 [2526] "L-779450"                                                                                                                                                             
 [2527] "MAGE-12_170-178_Peptide"                                                                                                                                              
 [2528] "MS-275"                                                                                                                                                               
 [2529] "Monoclonal_Antibody_CO17-1A"                                                                                                                                          
 [2530] "Monoclonal_Antibody_B3"                                                                                                                                               
 [2531] "PD-168393"                                                                                                                                                            
 [2532] "Polyclonal_Vaccine"                                                                                                                                                   
 [2533] "Radiolabeled_CC49"                                                                                                                                                    
 [2534] "Mutated_Ras_Peptide"                                                                                                                                                  
 [2535] "Rhodacyanine"                                                                                                                                                         
 [2536] "rV-MUC-1_Vaccine"                                                                                                                                                     
 [2537] "TheraCim_hR3"                                                                                                                                                         
 [2538] "Vitaxin-2"                                                                                                                                                            
 [2539] "Y_90_Anti-CEA_Monoclonal_Antibody"                                                                                                                                    
 [2540] "ZD-6126"                                                                                                                                                              
 [2541] "ZD-6474"                                                                                                                                                              
 [2542] "Isoxazole_Urea"                                                                                                                                                       
 [2543] "Monoclonal_Antibody_7C11"                                                                                                                                             
 [2544] "VHL16"                                                                                                                                                                
 [2545] "VHL14"                                                                                                                                                                
 [2546] "ALVAC-B7-CEA"                                                                                                                                                         
 [2547] "ALVAC-CEA_VCP248"                                                                                                                                                     
 [2548] "Atropine_Sulfate"                                                                                                                                                     
 [2549] "B7_Transfected_Melanoma_Cell_Vaccine"                                                                                                                                 
 [2550] "Berzofsky_Ras_P53_Peptide"                                                                                                                                            
 [2551] "Conjugated_Mononclonal_Antibody_CC49"                                                                                                                                 
 [2552] "D1_3-Mage-3_Fusion_Protein"                                                                                                                                           
 [2553] "EWS-FLI1_Type_1"                                                                                                                                                      
 [2554] "EWS-FLI1_Type_2"                                                                                                                                                      
 [2555] "Elliotts_B_Solution"                                                                                                                                                  
 [2556] "EPL_Diluent"                                                                                                                                                          
 [2557] "ESO-1_157-165_165v_Peptide"                                                                                                                                           
 [2558] "Lodenosine"                                                                                                                                                           
 [2559] "GM-CSF_cDNA-Gold_Complex"                                                                                                                                             
 [2560] "gp100_Adenovirus_Vaccine"                                                                                                                                             
 [2561] "gp100_cDNA-Gold_Complex"                                                                                                                                              
 [2562] "gp100_Plasmid_DNA"                                                                                                                                                    
 [2563] "gp100_and_GM-CSF_DNA-Gold_Vaccine"                                                                                                                                    
 [2564] "gp100-Fowlpox_Vaccine"                                                                                                                                                
 [2565] "gp100-pulsed_PBL"                                                                                                                                                     
 [2566] "gp100_ES209-217_210M"                                                                                                                                                 
 [2567] "gp100_154-162_Peptide"                                                                                                                                                
 [2568] "gp100_17-25"                                                                                                                                                          
 [2569] "gp100_209-217"                                                                                                                                                        
 [2570] "gp100_280-288_Peptide"                                                                                                                                                
 [2571] "gp100_44-59"                                                                                                                                                          
 [2572] "HPV-16E7_86-93"                                                                                                                                                       
 [2573] "KLH-Lymphoma_Ig_Vaccine"                                                                                                                                              
 [2574] "MART-1_26-35_27L"                                                                                                                                                     
 [2575] "MART-1_Adenovirus_Vaccine"                                                                                                                                            
 [2576] "MART-1_Vaccinia_Vaccine"                                                                                                                                              
 [2577] "MART-1_27-35_PEPTIDE"                                                                                                                                                 
 [2578] "MART-1_Fowlpox_Vaccine"                                                                                                                                               
 [2579] "Monoclonal_Antibody_95-5-49"                                                                                                                                          
 [2580] "Monoclonal_Antibody_95-6-22"                                                                                                                                          
 [2581] "_1B4M-DTPA-conjugated_muB3"                                                                                                                                           
 [2582] "Monoclonal_Antibody_HCC49DCH2"                                                                                                                                        
 [2583] "MOv-PBL"                                                                                                                                                              
 [2584] "Myeloma_Ig_Id-KLH_Conjugate_Vaccine"                                                                                                                                  
 [2585] "Oncovax-ID_IL-2_Vaccine"                                                                                                                                              
 [2586] "P53_264-272_Peptide_MPS-128"                                                                                                                                          
 [2587] "Paclitaxel_PPE_Microspheres"                                                                                                                                          
 [2588] "PCLUS_3-18MN"                                                                                                                                                         
 [2589] "PCLUS_6_1-18MN"                                                                                                                                                       
 [2590] "Peg_400_Diluent"                                                                                                                                                      
 [2591] "PEG_Diluent"                                                                                                                                                          
 [2592] "PG13-LNc8_Retroviral_Transduced_Cloned_T-Cells"                                                                                                                       
 [2593] "pNGVL3-hIL12"                                                                                                                                                         
 [2594] "PR18_ras-13_Cys_Peptide"                                                                                                                                              
 [2595] "PR54_ras-13_Asp_Peptide"                                                                                                                                              
 [2596] "PR5V10_ras-12_Val_Peptide"                                                                                                                                            
 [2597] "PR6V10_ras-12_Asp_Peptide"                                                                                                                                            
 [2598] "PR7v10_ras_12Ala_Peptide"                                                                                                                                             
 [2599] "Proteinase3_PR1_Peptide"                                                                                                                                              
 [2600] "PSA-3_Peptide"                                                                                                                                                        
 [2601] "PV701"                                                                                                                                                                
 [2602] "PAX3_FKHR"                                                                                                                                                            
 [2603] "Pyroxamide"                                                                                                                                                           
 [2604] "Ras_Peptide_ASP"                                                                                                                                                      
 [2605] "Ras_Peptide_CYS"                                                                                                                                                      
 [2606] "Ras_Peptide_VAL"                                                                                                                                                      
 [2607] "Recombinant_Fowlpox-Mgp100_Vaccine"                                                                                                                                   
 [2608] "Recombinant_Fowlpox-gp100p209"                                                                                                                                        
 [2609] "Fowlpox-Tyrosinase_Vaccine"                                                                                                                                           
 [2610] "Recombinant_Human_IL-4"                                                                                                                                               
 [2611] "Recombinant_Vaccinia-CEA"                                                                                                                                             
 [2612] "SB-AS02B_Adjuvant"                                                                                                                                                    
 [2613] "HspE7"                                                                                                                                                                
 [2614] "Sterile_0_01N_Hydrochloride"                                                                                                                                          
 [2615] "Telomerase_540-548_Peptide"                                                                                                                                           
 [2616] "Tetanus_Toxoid_Aluminum_Phosphate_Adsorbed_Vaccine"                                                                                                                   
 [2617] "TRP-2_180-188_Peptide"                                                                                                                                                
 [2618] "TRP1_0RF3_1-9"                                                                                                                                                        
 [2619] "Tumor_Cell_Vaccine_plus_BCG"                                                                                                                                          
 [2620] "TYROSINASE_206-214"                                                                                                                                                   
 [2621] "Tyrosinase_240-251_244S"                                                                                                                                              
 [2622] "TYROSINASE_368-376_370D"                                                                                                                                              
 [2623] "Unconjugated_Lymphoma_Ig_Id"                                                                                                                                          
 [2624] "Unconjugated_Myeloma_Ig_Id"                                                                                                                                           
 [2625] "VHL_Peptides"                                                                                                                                                         
 [2626] "VHL2_Y12M"                                                                                                                                                            
 [2627] "XK469R"                                                                                                                                                               
 [2628] "Telomerase_Inhibitor"                                                                                                                                                 
 [2629] "Verapamil_Hydrochloride"                                                                                                                                              
 [2630] "Topotecan_Hydrochloride"                                                                                                                                              
 [2631] "Fluoxetine_Hydrochloride"                                                                                                                                             
 [2632] "ONYX-015"                                                                                                                                                             
 [2633] "Glucose"                                                                                                                                                              
 [2634] "d-alpha-Tocopherol"                                                                                                                                                   
 [2635] "L-Selenomethionine"                                                                                                                                                   
 [2636] "Vitamin_E_Acetate"                                                                                                                                                    
 [2637] "Vaccine_Antigen"                                                                                                                                                      
 [2638] "Sodium_Chloride_0_9"                                                                                                                                                  
 [2639] "Recombinant_Fowlpox-Prostate_Specific_Antigen"                                                                                                                        
 [2640] "Recombinant_Fowlpox-B7_1"                                                                                                                                             
 [2641] "Fowlpox_Vaccine"                                                                                                                                                      
 [2642] "Recombinant_Vaccinia-B7_1"                                                                                                                                            
 [2643] "Peripheral_Blood_Lymphocyte_Vaccine"                                                                                                                                  
 [2644] "DNA_Binding_Agent"                                                                                                                                                    
 [2645] "Camptothecin_Analogue"                                                                                                                                                
 [2646] "Actinomycin_F1"                                                                                                                                                       
 [2647] "Linker_DNA"                                                                                                                                                           
 [2648] "Glucosidase_Inhibitor"                                                                                                                                                
 [2649] "Mesothorium"                                                                                                                                                          
 [2650] "Polyvalent_Vaccine"                                                                                                                                                   
 [2651] "Congenital_Abnormality"                                                                                                                                               
 [2652] "Achlorhydria"                                                                                                                                                         
 [2653] "AIDS"                                                                                                                                                                 
 [2654] "Adenocarcinoma"                                                                                                                                                       
 [2655] "Papillary_Adenocarcinoma"                                                                                                                                             
 [2656] "Warthin_s_Tumor"                                                                                                                                                      
 [2657] "Adenoma"                                                                                                                                                              
 [2658] "Basophilic_Adenoma"                                                                                                                                                   
 [2659] "Pituitary_Gland_Chromophobe_Adenoma"                                                                                                                                  
 [2660] "Adrenal_Cortex_Neoplasm"                                                                                                                                              
 [2661] "Adrenal_Gland_Neoplasm"                                                                                                                                               
 [2662] "Adrenal_Rest_Neoplasm"                                                                                                                                                
 [2663] "Side_Effect"                                                                                                                                                          
 [2664] "Chronic_Idiopathic_Myelofibrosis"                                                                                                                                     
 [2665] "Granulocytopenia"                                                                                                                                                     
 [2666] "AIDS_Dementia"                                                                                                                                                        
 [2667] "Alopecia"                                                                                                                                                             
 [2668] "Alzheimer_s_Disease"                                                                                                                                                  
 [2669] "Amnesia"                                                                                                                                                              
 [2670] "Amyloidosis"                                                                                                                                                          
 [2671] "Anemia"                                                                                                                                                               
 [2672] "Aplastic_Anemia"                                                                                                                                                      
 [2673] "Pernicious_Anemia"                                                                                                                                                    
 [2674] "Refractory_Anemia"                                                                                                                                                    
 [2675] "Aneuploidy"                                                                                                                                                           
 [2676] "Angiokeratoma"                                                                                                                                                        
 [2677] "Anorexia"                                                                                                                                                             
 [2678] "Anoxia"                                                                                                                                                               
 [2679] "Anal_Neoplasm"                                                                                                                                                        
 [2680] "Anxiety_Disorder"                                                                                                                                                     
 [2681] "Neoplasm_of_the_Diffuse_Neuroendocrine_System"                                                                                                                        
 [2682] "Androblastoma"                                                                                                                                                        
 [2683] "Arrhythmia"                                                                                                                                                           
 [2684] "Arteriovenous_Malformation"                                                                                                                                           
 [2685] "Arthritis"                                                                                                                                                            
 [2686] "Rheumatoid_Arthritis"                                                                                                                                                 
 [2687] "Ascites"                                                                                                                                                              
 [2688] "Aspergillosis"                                                                                                                                                        
 [2689] "Ataxia_Telangiectasia_Syndrome"                                                                                                                                       
 [2690] "Atelectasis"                                                                                                                                                          
 [2691] "Autoimmune_Disease"                                                                                                                                                   
 [2692] "Bacterial_Infection"                                                                                                                                                  
 [2693] "Barrett_s_Esophagus"                                                                                                                                                  
 [2694] "Basal_Cell_Nevus_Syndrome"                                                                                                                                            
 [2695] "Psychiatric_Disorder"                                                                                                                                                 
 [2696] "Benign_Colon_Neoplasm"                                                                                                                                                
 [2697] "Benign_Ovarian_Neoplasm"                                                                                                                                              
 [2698] "Benign_Skin_Neoplasm"                                                                                                                                                 
 [2699] "Benign_Prostatic_Hyperplasia"                                                                                                                                         
 [2700] "Bile_Duct_Neoplasm"                                                                                                                                                   
 [2701] "Biliary_Tract_Disorder"                                                                                                                                               
 [2702] "Bladder_Disorder"                                                                                                                                                     
 [2703] "Bladder_Neoplasm"                                                                                                                                                     
 [2704] "Coagulation_Disorder"                                                                                                                                                 
 [2705] "Bloom_Syndrome"                                                                                                                                                       
 [2706] "Bone_Cyst"                                                                                                                                                            
 [2707] "Bone_Marrow_Hyperplasia"                                                                                                                                              
 [2708] "Skin_Squamous_Cell_Carcinoma_in_situ"                                                                                                                                 
 [2709] "Brain_Neoplasm"                                                                                                                                                       
 [2710] "Branchial_Cyst"                                                                                                                                                       
 [2711] "Non-Neoplastic_Breast_Disorder"                                                                                                                                       
 [2712] "Breast_Neoplasm"                                                                                                                                                      
 [2713] "Bronchitis"                                                                                                                                                           
 [2714] "Burkitt_s_Lymphoma"                                                                                                                                                   
 [2715] "Cachexia"                                                                                                                                                             
 [2716] "Vulvovaginal_Candidiasis"                                                                                                                                             
 [2717] "Carcinoid_Tumor"                                                                                                                                                      
 [2718] "Carcinoma"                                                                                                                                                            
 [2719] "Carcinoma_in_situ"                                                                                                                                                    
 [2720] "Female_Breast_Carcinoma"                                                                                                                                              
 [2721] "Prostate_Adenocarcinoma"                                                                                                                                              
 [2722] "Malignant_Skin_Neoplasm"                                                                                                                                              
 [2723] "Basal_Cell_Carcinoma"                                                                                                                                                 
 [2724] "Basosquamous_Cell_Carcinoma"                                                                                                                                          
 [2725] "Bronchiolo-Alveolar_Lung_Carcinoma"                                                                                                                                   
 [2726] "Ductal_Carcinoma_in_situ_of_the_Breast"                                                                                                                               
 [2727] "Non-Small_Cell_Lung_Carcinoma"                                                                                                                                        
 [2728] "Papillary_Carcinoma"                                                                                                                                                  
 [2729] "Scirrhous_Adenocarcinoma"                                                                                                                                             
 [2730] "Squamous_Cell_Carcinoma"                                                                                                                                              
 [2731] "Transitional_Cell_Carcinoma"                                                                                                                                          
 [2732] "Cardiovascular_Disorder"                                                                                                                                              
 [2733] "Carotid_Body_Paraganglioma"                                                                                                                                           
 [2734] "Cementoma"                                                                                                                                                            
 [2735] "Central_Nervous_System_Disorder"                                                                                                                                      
 [2736] "Cerebellar_Neoplasm"                                                                                                                                                  
 [2737] "Cerebral_Arteriovenous_Malformation"                                                                                                                                  
 [2738] "Intraventricular_Brain_Neoplasm"                                                                                                                                      
 [2739] "Cerebrovascular_Disorder"                                                                                                                                             
 [2740] "Cervical_Polyp"                                                                                                                                                       
 [2741] "Cervical_Neoplasm"                                                                                                                                                    
 [2742] "Chediak-Higashi_Syndrome"                                                                                                                                             
 [2743] "Bile_Duct_Adenoma"                                                                                                                                                    
 [2744] "Choledochal_Cyst"                                                                                                                                                     
 [2745] "Cholesteatoma"                                                                                                                                                        
 [2746] "Chondroblastoma"                                                                                                                                                      
 [2747] "Chondrosarcoma"                                                                                                                                                       
 [2748] "Chordoma"                                                                                                                                                             
 [2749] "Choriocarcinoma"                                                                                                                                                      
 [2750] "Choroid_Neoplasm"                                                                                                                                                     
 [2751] "Chromosomal_Aberration"                                                                                                                                               
 [2752] "Cirrhosis"                                                                                                                                                            
 [2753] "Ulcerative_Colitis"                                                                                                                                                   
 [2754] "Colon_Neoplasm"                                                                                                                                                       
 [2755] "Colon_Polyp"                                                                                                                                                          
 [2756] "Colorectal_Carcinoma"                                                                                                                                                 
 [2757] "Colorectal_Neoplasm"                                                                                                                                                  
 [2758] "Communication_Disorder"                                                                                                                                               
 [2759] "Complication"                                                                                                                                                         
 [2760] "Condyloma_Acuminatum"                                                                                                                                                 
 [2761] "Conjunctival_Neoplasm"                                                                                                                                                
 [2762] "Seizure"                                                                                                                                                              
 [2763] "Cranial_Nerve_Neoplasm"                                                                                                                                               
 [2764] "Craniopharyngioma"                                                                                                                                                    
 [2765] "Crohn_s_Disease"                                                                                                                                                      
 [2766] "Cryptococcosis"                                                                                                                                                       
 [2767] "Cushing_s_Syndrome"                                                                                                                                                   
 [2768] "Adenoid_Cystic_Carcinoma"                                                                                                                                             
 [2769] "Cystadenocarcinoma"                                                                                                                                                   
 [2770] "Cystadenoma"                                                                                                                                                          
 [2771] "Mucinous_Cystadenoma"                                                                                                                                                 
 [2772] "Papillary_Cystadenoma"                                                                                                                                                
 [2773] "Cystic_Fibrosis"                                                                                                                                                      
 [2774] "Cystinosis"                                                                                                                                                           
 [2775] "Phyllodes_Tumor"                                                                                                                                                      
 [2776] "Cyst"                                                                                                                                                                 
 [2777] "Cytopenia"                                                                                                                                                            
 [2778] "Dysphagia"                                                                                                                                                            
 [2779] "Delirium"                                                                                                                                                             
 [2780] "Depression"                                                                                                                                                           
 [2781] "Dermatitis"                                                                                                                                                           
 [2782] "Dermatosis_Papulosa_Nigra"                                                                                                                                            
 [2783] "Diabetes_Mellitus"                                                                                                                                                    
 [2784] "Insulin_Dependent_Diabetes_Mellitus"                                                                                                                                  
 [2785] "Diarrhea"                                                                                                                                                             
 [2786] "DiGeorge_s_Syndrome"                                                                                                                                                  
 [2787] "Gastrointestinal_Disorder"                                                                                                                                            
 [2788] "Diseases_and_Disorders"                                                                                                                                               
 [2789] "Disseminated_Intravascular_Coagulation"                                                                                                                               
 [2790] "Down_Syndrome"                                                                                                                                                        
 [2791] "Dumping_Syndrome"                                                                                                                                                     
 [2792] "Duodenal_Neoplasm"                                                                                                                                                    
 [2793] "Dysgerminoma"                                                                                                                                                         
 [2794] "Dyspareunia"                                                                                                                                                          
 [2795] "Dyspnea"                                                                                                                                                              
 [2796] "Dysuria"                                                                                                                                                              
 [2797] "Ear_Neoplasm"                                                                                                                                                         
 [2798] "Eczema"                                                                                                                                                               
 [2799] "Edema"                                                                                                                                                                
 [2800] "Effusion"                                                                                                                                                             
 [2801] "Elliptocytosis"                                                                                                                                                       
 [2802] "Tumor_Embolism"                                                                                                                                                       
 [2803] "Experimental_Allergic_Encephalomyelitis"                                                                                                                              
 [2804] "Enchondroma"                                                                                                                                                          
 [2805] "Enchondromatosis"                                                                                                                                                     
 [2806] "Endocrine_Disorder"                                                                                                                                                   
 [2807] "Endocrine_Neoplasm"                                                                                                                                                   
 [2808] "Yolk_Sac_Tumor"                                                                                                                                                       
 [2809] "Endometrial_Neoplasm"                                                                                                                                                 
 [2810] "Endometrial_Hyperplasia"                                                                                                                                              
 [2811] "Endometriosis"                                                                                                                                                        
 [2812] "Eosinophilia"                                                                                                                                                         
 [2813] "Eosinophilic_Granuloma"                                                                                                                                               
 [2814] "Ependymoma"                                                                                                                                                           
 [2815] "Sebaceous_Cyst"                                                                                                                                                       
 [2816] "Epidural_Spinal_Canal_Neoplasm"                                                                                                                                       
 [2817] "Epilepsy"                                                                                                                                                             
 [2818] "Generalized_Epilepsy"                                                                                                                                                 
 [2819] "Grand_Mal_Epilepsy"                                                                                                                                                   
 [2820] "Petit_Mal_Epilepsy"                                                                                                                                                   
 [2821] "Erythema_Multiforme"                                                                                                                                                  
 [2822] "Erythroplakia"                                                                                                                                                        
 [2823] "Esophageal_Cyst"                                                                                                                                                      
 [2824] "Esophageal_Disorder"                                                                                                                                                  
 [2825] "Esophageal_Neoplasm"                                                                                                                                                  
 [2826] "Exostosis"                                                                                                                                                            
 [2827] "Eye_Neoplasm"                                                                                                                                                         
 [2828] "Eyelid_Neoplasm"                                                                                                                                                      
 [2829] "Fallopian_Tube_Neoplasm"                                                                                                                                              
 [2830] "Familiar_Atypical_Multiple_Mole"                                                                                                                                      
 [2831] "Fanconi_Syndrome"                                                                                                                                                     
 [2832] "Fanconi_s_Anemia"                                                                                                                                                     
 [2833] "Fatigue"                                                                                                                                                              
 [2834] "Chronic_Fatigue_Syndrome"                                                                                                                                             
 [2835] "Fever"                                                                                                                                                                
 [2836] "Breast_Fibrocystic_Change"                                                                                                                                            
 [2837] "Fibrodysplasia_Ossificans_Progressiva"                                                                                                                                
 [2838] "Fibroma"                                                                                                                                                              
 [2839] "Fibromatosis"                                                                                                                                                         
 [2840] "Fibrosarcoma"                                                                                                                                                         
 [2841] "Fibrosis"                                                                                                                                                             
 [2842] "Fistula"                                                                                                                                                              
 [2843] "Fracture"                                                                                                                                                             
 [2844] "Pathologic_Fracture"                                                                                                                                                  
 [2845] "Gallbladder_Neoplasm"                                                                                                                                                 
 [2846] "Ganglioneuroma"                                                                                                                                                       
 [2847] "G-Cell_Gastrin_Producing_Neoplasm"                                                                                                                                    
 [2848] "Gastrointestinal_Neoplasm"                                                                                                                                            
 [2849] "Female_Reproductive_System_Neoplasm"                                                                                                                                  
 [2850] "Male_Reproductive_System_Neoplasm"                                                                                                                                    
 [2851] "Giant_Cell_Tumor"                                                                                                                                                     
 [2852] "Angiofollicular_Lymphoid_Hyperplasia"                                                                                                                                 
 [2853] "Gingival_Neoplasm"                                                                                                                                                    
 [2854] "Glioblastoma"                                                                                                                                                         
 [2855] "Neuroglial_Tumor"                                                                                                                                                     
 [2856] "Glomus_Tumor"                                                                                                                                                         
 [2857] "Jugulotympanic_Paraganglioma"                                                                                                                                         
 [2858] "Pancreatic_Alpha_Cell_Glucagon_Producing_Neoplasm"                                                                                                                    
 [2859] "Graft_Versus_Host_Disease"                                                                                                                                            
 [2860] "Granuloma"                                                                                                                                                            
 [2861] "Granuloma_Inguinale"                                                                                                                                                  
 [2862] "Foreign_Body_Granuloma"                                                                                                                                               
 [2863] "Giant_Cell_Granuloma"                                                                                                                                                 
 [2864] "Laryngeal_Granuloma"                                                                                                                                                  
 [2865] "Plasma_Cell_Granuloma"                                                                                                                                                
 [2866] "Granulosa_Cell_Tumor"                                                                                                                                                 
 [2867] "Graves_Disease"                                                                                                                                                       
 [2868] "Gynandroblastoma"                                                                                                                                                     
 [2869] "Gynecomastia"                                                                                                                                                         
 [2870] "Hairy_Nevus"                                                                                                                                                          
 [2871] "Hamartoma"                                                                                                                                                            
 [2872] "Cowden_Syndrome"                                                                                                                                                      
 [2873] "Head_and_Neck_Neoplasm"                                                                                                                                               
 [2874] "Hearing_Disorder"                                                                                                                                                     
 [2875] "Heart_Disease"                                                                                                                                                        
 [2876] "Congestive_Heart_Failure"                                                                                                                                             
 [2877] "Cardiac_Neoplasm"                                                                                                                                                     
 [2878] "Heavy_Chain_Disease"                                                                                                                                                  
 [2879] "Gamma_Heavy_Chain_Disease"                                                                                                                                            
 [2880] "Hemangioendothelioma"                                                                                                                                                 
 [2881] "Hemangioma"                                                                                                                                                           
 [2882] "Cavernous_Hemangioma"                                                                                                                                                 
 [2883] "Hemangiopericytoma"                                                                                                                                                   
 [2884] "Angiosarcoma"                                                                                                                                                         
 [2885] "Hematuria"                                                                                                                                                            
 [2886] "Hemoglobinopathy"                                                                                                                                                     
 [2887] "Hemophilia"                                                                                                                                                           
 [2888] "Hemoptysis"                                                                                                                                                           
 [2889] "Hepatitis"                                                                                                                                                            
 [2890] "Hepatitis_A"                                                                                                                                                          
 [2891] "Hepatitis_B"                                                                                                                                                          
 [2892] "Hepatitis_C"                                                                                                                                                          
 [2893] "Hepatocellular_Carcinoma"                                                                                                                                             
 [2894] "Hepatomegaly"                                                                                                                                                         
 [2895] "Genetic_Disorder"                                                                                                                                                     
 [2896] "Von_Hippel-Lindau_Syndrome"                                                                                                                                           
 [2897] "Histiocytosis"                                                                                                                                                        
 [2898] "Langerhans_Cell_Histiocytosis"                                                                                                                                        
 [2899] "HIV_Infection"                                                                                                                                                        
 [2900] "Hot_Flashes"                                                                                                                                                          
 [2901] "Hydatidiform_Mole"                                                                                                                                                    
 [2902] "Hydrocephalus"                                                                                                                                                        
 [2903] "Hypercalcemia"                                                                                                                                                        
 [2904] "Hyperplasia"                                                                                                                                                          
 [2905] "Hypersensitivity"                                                                                                                                                     
 [2906] "Delayed-Type_Hypersensitivity"                                                                                                                                        
 [2907] "Immediate_Hypersensitivity"                                                                                                                                           
 [2908] "Hypertension"                                                                                                                                                         
 [2909] "Malignant_Hypertension"                                                                                                                                               
 [2910] "Portal_Hypertension"                                                                                                                                                  
 [2911] "Pulmonary_Hypertension"                                                                                                                                               
 [2912] "Renal_Hypertension"                                                                                                                                                   
 [2913] "Hypertensive_Crisis"                                                                                                                                                  
 [2914] "Hyperthyroidism"                                                                                                                                                      
 [2915] "Hypertrophy"                                                                                                                                                          
 [2916] "Hypertrophy_of_the_Breast"                                                                                                                                            
 [2917] "Hypoglycemia"                                                                                                                                                         
 [2918] "Hypopharyngeal_Neoplasm"                                                                                                                                              
 [2919] "Hypotension"                                                                                                                                                          
 [2920] "Hypothalamic_Neoplasm"                                                                                                                                                
 [2921] "Ileal_Neoplasm"                                                                                                                                                       
 [2922] "Immunodeficiency_Syndrome"                                                                                                                                            
 [2923] "Alpha_Heavy_Chain_Disease"                                                                                                                                            
 [2924] "Impotence"                                                                                                                                                            
 [2925] "Epidermal_Inclusion_Cyst"                                                                                                                                             
 [2926] "Inflammation"                                                                                                                                                         
 [2927] "Inflammatory_Bowel_Disease"                                                                                                                                           
 [2928] "Infratentorial_Neoplasm"                                                                                                                                              
 [2929] "Pancreatic_Beta_Cell_Insulin_Producing_Neoplasm"                                                                                                                      
 [2930] "Intestinal_Neoplasm"                                                                                                                                                  
 [2931] "Iris_Neoplasm"                                                                                                                                                        
 [2932] "Jaundice"                                                                                                                                                             
 [2933] "Hyperimmunoglobulin_E_Syndrome"                                                                                                                                       
 [2934] "Keloid"                                                                                                                                                               
 [2935] "Keratoacanthoma"                                                                                                                                                      
 [2936] "Diffuse_Palmoplantar_Keratoderma"                                                                                                                                     
 [2937] "Actinic_Solar_Keratosis"                                                                                                                                              
 [2938] "Renal_Disorder"                                                                                                                                                       
 [2939] "Renal_Neoplasm"                                                                                                                                                       
 [2940] "Penile_Leukoplakia"                                                                                                                                                   
 [2941] "Vulval_Leukoplakia"                                                                                                                                                   
 [2942] "Krukenberg_Tumor"                                                                                                                                                     
 [2943] "Lactose_Intolerance"                                                                                                                                                  
 [2944] "Lambert_Eaton_Myasthenic_Syndrome"                                                                                                                                    
 [2945] "Laryngeal_Neoplasm"                                                                                                                                                   
 [2946] "Leiomyoma"                                                                                                                                                            
 [2947] "Leiomyosarcoma"                                                                                                                                                       
 [2948] "Lentigo"                                                                                                                                                              
 [2949] "Letterer-Siwe_Disease"                                                                                                                                                
 [2950] "Leukemia"                                                                                                                                                             
 [2951] "B-Cell_Leukemia"                                                                                                                                                      
 [2952] "Chronic_Lymphocytic_Leukemia"                                                                                                                                         
 [2953] "Acute_Basophilic_Leukemia"                                                                                                                                            
 [2954] "cALLa_Positive_Lymphoblastic_Leukemia"                                                                                                                                
 [2955] "Acute_Lymphoblastic_Leukemia"                                                                                                                                         
 [2956] "Childhood_Acute_Lymphoblastic_Leukemia"                                                                                                                               
 [2957] "Mast_Cell_Leukemia"                                                                                                                                                   
 [2958] "Acute_Megakaryoblastic_Leukemia"                                                                                                                                      
 [2959] "Acute_Myeloid_Leukemia"                                                                                                                                               
 [2960] "Myeloid_Leukemia"                                                                                                                                                     
 [2961] "Accelerated_Phase_Chronic_Myelogenous_Leukemia"                                                                                                                       
 [2962] "Chronic_Myelogenous_Leukemia"                                                                                                                                         
 [2963] "Chronic_Phase_Chronic_Myelogenous_Leukemia"                                                                                                                           
 [2964] "Philadelphia-Negative_Myelogenous_Leukemia"                                                                                                                           
 [2965] "Philadelphia-Positive_Myelogenous_Leukemia"                                                                                                                           
 [2966] "Chronic_Myelomonocytic_Leukemia"                                                                                                                                      
 [2967] "Chronic_Neutrophilic_Leukemia"                                                                                                                                        
 [2968] "Plasma_Cell_Leukemia"                                                                                                                                                 
 [2969] "Prolymphocytic_Leukemia"                                                                                                                                              
 [2970] "Acute_Promyelocytic_Leukemia"                                                                                                                                         
 [2971] "Precursor_T_Lymphoblastic_Leukemia"                                                                                                                                   
 [2972] "Adult_T-Cell_Lymphoma_Leukemia"                                                                                                                                       
 [2973] "Leukemoid_Reaction"                                                                                                                                                   
 [2974] "Leukoplakia"                                                                                                                                                          
 [2975] "Oral_Leukoplakia"                                                                                                                                                     
 [2976] "Leydig_Cell_Tumor"                                                                                                                                                    
 [2977] "Lichen_Planus"                                                                                                                                                        
 [2978] "Linitis_Plastica"                                                                                                                                                     
 [2979] "Lip_Neoplasm"                                                                                                                                                         
 [2980] "Lipoma"                                                                                                                                                               
 [2981] "Lipomatosis"                                                                                                                                                          
 [2982] "Liposarcoma"                                                                                                                                                          
 [2983] "Hepatic_Disorder"                                                                                                                                                     
 [2984] "Breast_Lump"                                                                                                                                                          
 [2985] "Lung_Disorder"                                                                                                                                                        
 [2986] "Chronic_Obstructive_Airways_Disease"                                                                                                                                  
 [2987] "Lung_Neoplasm"                                                                                                                                                        
 [2988] "Systemic_Lupus_Erythematosus"                                                                                                                                         
 [2989] "Luteoma"                                                                                                                                                              
 [2990] "Lymphangioendothelioma"                                                                                                                                               
 [2991] "Lymphangiomyoma"                                                                                                                                                      
 [2992] "Lymphangiosarcoma"                                                                                                                                                    
 [2993] "Lymphadenopathy"                                                                                                                                                      
 [2994] "Lymphedema"                                                                                                                                                           
 [2995] "Lymphoma"                                                                                                                                                             
 [2996] "Follicular_Lymphoma"                                                                                                                                                  
 [2997] "Mixed_Cell_Lymphoma"                                                                                                                                                  
 [2998] "Non-Hodgkin_s_Lymphoma"                                                                                                                                               
 [2999] "Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia"                                                                                                           
 [3000] "Maffucci_Syndrome"                                                                                                                                                    
 [3001] "Malabsorption_Syndrome"                                                                                                                                               
 [3002] "Carcinoid_Syndrome"                                                                                                                                                   
 [3003] "Malignant_Retinal_Neoplasm"                                                                                                                                           
 [3004] "Benign_Mastocytoma"                                                                                                                                                   
 [3005] "Diffuse_Cutaneous_Mastocytosis"                                                                                                                                       
 [3006] "Maxillary_Sinus_Neoplasm"                                                                                                                                             
 [3007] "Mediastinal_Cyst"                                                                                                                                                     
 [3008] "Mediastinal_Neoplasm"                                                                                                                                                 
 [3009] "Medulloblastoma"                                                                                                                                                      
 [3010] "Meigs_Syndrome"                                                                                                                                                       
 [3011] "Melanoma"                                                                                                                                                             
 [3012] "Multiple_Endocrine_Neoplasia_Type_I"                                                                                                                                  
 [3013] "Multiple_Endocrine_Neoplasia_Type_II"                                                                                                                                 
 [3014] "Multiple_Endocrine_Neoplasia_Type_III"                                                                                                                                
 [3015] "Menarche"                                                                                                                                                             
 [3016] "Meningeal_Neoplasm"                                                                                                                                                   
 [3017] "Meningioma"                                                                                                                                                           
 [3018] "Menopause"                                                                                                                                                            
 [3019] "Menstruation"                                                                                                                                                         
 [3020] "Mesenchymoma"                                                                                                                                                         
 [3021] "Mesothelioma"                                                                                                                                                         
 [3022] "Metabolic_Disorder"                                                                                                                                                   
 [3023] "Metaplasia"                                                                                                                                                           
 [3024] "Squamous_Metaplasia"                                                                                                                                                  
 [3025] "Milium_Cyst"                                                                                                                                                          
 [3026] "Monosomy"                                                                                                                                                             
 [3027] "Oral_Disorder"                                                                                                                                                        
 [3028] "Appendicele_Mucocele"                                                                                                                                                 
 [3029] "Plasma_Cell_Myeloma"                                                                                                                                                  
 [3030] "Multiple_Sclerosis"                                                                                                                                                   
 [3031] "Musculoskeletal_Pain"                                                                                                                                                 
 [3032] "Fungal_Infection"                                                                                                                                                     
 [3033] "Mycosis_Fungoides"                                                                                                                                                    
 [3034] "Myelodysplastic_Syndrome"                                                                                                                                             
 [3035] "Myelofibrosis"                                                                                                                                                        
 [3036] "Acute_Myeloid_Leukemia_without_Maturation"                                                                                                                            
 [3037] "Acute_Myeloid_Leukemia_with_Maturation"                                                                                                                               
 [3038] "Benign_Granular_Cell_Tumor"                                                                                                                                           
 [3039] "Myositis_Ossificans"                                                                                                                                                  
 [3040] "Angiomyxoma"                                                                                                                                                          
 [3041] "Myxosarcoma"                                                                                                                                                          
 [3042] "Nasal_Cavity_Polyp"                                                                                                                                                   
 [3043] "Nasopharyngeal_Neoplasm"                                                                                                                                              
 [3044] "Nausea"                                                                                                                                                               
 [3045] "Nausea_and_Vomiting"                                                                                                                                                  
 [3046] "Neck_Neoplasm"                                                                                                                                                        
 [3047] "Metastatic_Neoplasm"                                                                                                                                                  
 [3048] "Neoplasm"                                                                                                                                                             
 [3049] "Neoplasm_by_Site"                                                                                                                                                     
 [3050] "Embryonal_Neoplasm"                                                                                                                                                   
 [3051] "Radiation-Related_Neoplasm"                                                                                                                                           
 [3052] "Hereditary_Neoplastic_Syndrome"                                                                                                                                       
 [3053] "Wilms_Tumor"                                                                                                                                                          
 [3054] "Nervous_System_Neoplasm"                                                                                                                                              
 [3055] "Schwannoma"                                                                                                                                                           
 [3056] "Neuroblastoma"                                                                                                                                                        
 [3057] "Neurofibroma"                                                                                                                                                         
 [3058] "Neurofibromatosis_Type_1"                                                                                                                                             
 [3059] "Neurofibromatosis_Type_2"                                                                                                                                             
 [3060] "Neuroma"                                                                                                                                                              
 [3061] "Acoustic_Schwannoma"                                                                                                                                                  
 [3062] "Neutropenia"                                                                                                                                                          
 [3063] "Night_Sweating"                                                                                                                                                       
 [3064] "Nodule"                                                                                                                                                               
 [3065] "Nystagmus"                                                                                                                                                            
 [3066] "Obesity"                                                                                                                                                              
 [3067] "Obstruction"                                                                                                                                                          
 [3068] "Ocular_Hypertension"                                                                                                                                                  
 [3069] "Odontogenic_Neoplasm"                                                                                                                                                 
 [3070] "Odontoma"                                                                                                                                                             
 [3071] "Oligodendroglioma"                                                                                                                                                    
 [3072] "Opportunistic_Infections"                                                                                                                                             
 [3073] "Orbit_Neoplasm"                                                                                                                                                       
 [3074] "Oropharyngeal_Neoplasm"                                                                                                                                               
 [3075] "Bone_Paget_s_Disease"                                                                                                                                                 
 [3076] "Osteoarthritis"                                                                                                                                                       
 [3077] "Osteoblastoma"                                                                                                                                                        
 [3078] "Osteochondroma"                                                                                                                                                       
 [3079] "Osteoma"                                                                                                                                                              
 [3080] "Osteoid_Osteoma"                                                                                                                                                      
 [3081] "Osteoporosis"                                                                                                                                                         
 [3082] "External_Ear_Infection"                                                                                                                                               
 [3083] "Ovarian_Cyst"                                                                                                                                                         
 [3084] "Paget_s_Disease_of_the_Nipple"                                                                                                                                        
 [3085] "Extramammary_Paget_s_Disease"                                                                                                                                         
 [3086] "Pain"                                                                                                                                                                 
 [3087] "Pancreatic_Cyst"                                                                                                                                                      
 [3088] "Pancreatic_Neoplasm"                                                                                                                                                  
 [3089] "Pancreatitis"                                                                                                                                                         
 [3090] "Papilledema"                                                                                                                                                          
 [3091] "Paraganglionic_Neoplasm"                                                                                                                                              
 [3092] "Extra-Adrenal_Paraganglioma"                                                                                                                                          
 [3093] "Paralysis"                                                                                                                                                            
 [3094] "Paraneoplastic_Syndrome"                                                                                                                                              
 [3095] "Parapsoriasis"                                                                                                                                                        
 [3096] "Parathyroid_Neoplasm"                                                                                                                                                 
 [3097] "Parotid_Gland_Neoplasm"                                                                                                                                               
 [3098] "Partial_Thromboplastin_Time"                                                                                                                                          
 [3099] "Penile_Fibromatosis"                                                                                                                                                  
 [3100] "Penile_Neoplasm"                                                                                                                                                      
 [3101] "Peptic_Ulcer"                                                                                                                                                         
 [3102] "Pericardial_Effusion"                                                                                                                                                 
 [3103] "Peripheral_Nervous_System_Neoplasm"                                                                                                                                   
 [3104] "Peritoneal_Neoplasm"                                                                                                                                                  
 [3105] "Petechia"                                                                                                                                                             
 [3106] "Peutz-Jeghers_Syndrome"                                                                                                                                               
 [3107] "Pharyngeal_Neoplasm"                                                                                                                                                  
 [3108] "Pheochromocytoma"                                                                                                                                                     
 [3109] "Skin_Discoloration"                                                                                                                                                   
 [3110] "Pineal_Region_Neoplasm"                                                                                                                                               
 [3111] "Pituitary_Gland_Adenoma"                                                                                                                                              
 [3112] "Pituitary_Gland_Neoplasm"                                                                                                                                             
 [3113] "Pleural_Effusion"                                                                                                                                                     
 [3114] "Pleural_Neoplasm"                                                                                                                                                     
 [3115] "Pneumonia"                                                                                                                                                            
 [3116] "Pneumocystis_Carinii_Pneumonia"                                                                                                                                       
 [3117] "Rothmund-Thomson_Syndrome"                                                                                                                                            
 [3118] "Polycythemia_Vera"                                                                                                                                                    
 [3119] "Fibroepithelial_Polyp"                                                                                                                                                
 [3120] "Polyploidy"                                                                                                                                                           
 [3121] "Familial_Adenomatous_Polyposis"                                                                                                                                       
 [3122] "Polyp"                                                                                                                                                                
 [3123] "Precancerous_Condition"                                                                                                                                               
 [3124] "Prolactin_Secreting_Pituitary_Gland_Adenoma"                                                                                                                          
 [3125] "Prostate_Neoplasm"                                                                                                                                                    
 [3126] "Pruritus"                                                                                                                                                             
 [3127] "Pseudomyxoma_Peritonei"                                                                                                                                               
 [3128] "Psoriasis"                                                                                                                                                            
 [3129] "Sexual_Dysfunction"                                                                                                                                                   
 [3130] "Emphysema"                                                                                                                                                            
 [3131] "Radiation-Induced_Dermatitis"                                                                                                                                         
 [3132] "Rectal_Neoplasm"                                                                                                                                                      
 [3133] "Rectal_Polyp"                                                                                                                                                         
 [3134] "Recurrence"                                                                                                                                                           
 [3135] "Adult_Respiratory_Distress_Syndrome"                                                                                                                                  
 [3136] "Respiratory_Syncytial_Virus_Infection"                                                                                                                                
 [3137] "Respiratory_Tract_Neoplasm"                                                                                                                                           
 [3138] "Solitary_Reticulohistiocytoma"                                                                                                                                        
 [3139] "Retroperitoneal_Neoplasm"                                                                                                                                             
 [3140] "Rhabdomyoma"                                                                                                                                                          
 [3141] "Rhabdomyosarcoma"                                                                                                                                                     
 [3142] "Supernumerary_Circular_Chromosome"                                                                                                                                    
 [3143] "Salivary_Gland_Neoplasm"                                                                                                                                              
 [3144] "Schizophrenia"                                                                                                                                                        
 [3145] "Sebaceous_Neoplasm"                                                                                                                                                   
 [3146] "Septicemia"                                                                                                                                                           
 [3147] "Sexually_Transmitted_Disorder"                                                                                                                                        
 [3148] "Sezary_Syndrome"                                                                                                                                                      
 [3149] "Finding"                                                                                                                                                              
 [3150] "Gastrointestinal_System_Signs_and_Symptoms"                                                                                                                           
 [3151] "Silicosis"                                                                                                                                                            
 [3152] "Vocal_Cord_Nodule"                                                                                                                                                    
 [3153] "Skin_Disorder"                                                                                                                                                        
 [3154] "Skin_Neoplasm"                                                                                                                                                        
 [3155] "Skin_Nodule"                                                                                                                                                          
 [3156] "Skin_Tag"                                                                                                                                                             
 [3157] "Skull_Neoplasm"                                                                                                                                                       
 [3158] "Sleep_Disorder"                                                                                                                                                       
 [3159] "Soft_Tissue_Neoplasm"                                                                                                                                                 
 [3160] "Solitary_Breast_Cyst"                                                                                                                                                 
 [3161] "Delta_Cell_Somatostatin_Producing_Neoplasm"                                                                                                                           
 [3162] "Spinal_Cord_Compression"                                                                                                                                              
 [3163] "Spinal_Cord_Neoplasm"                                                                                                                                                 
 [3164] "Intraspinal_Neoplasm"                                                                                                                                                 
 [3165] "Splenic_Neoplasm"                                                                                                                                                     
 [3166] "Splenomegaly"                                                                                                                                                         
 [3167] "Erythema_Multiforme_Major"                                                                                                                                            
 [3168] "Gastric_Neoplasm"                                                                                                                                                     
 [3169] "Gastric_Ulcer"                                                                                                                                                        
 [3170] "Post-Traumatic_Stress_Disorder"                                                                                                                                       
 [3171] "Cerebrovascular_Accident"                                                                                                                                             
 [3172] "Sturge-Weber_Syndrome"                                                                                                                                                
 [3173] "Sublingual_Gland_Neoplasm"                                                                                                                                            
 [3174] "Submandibular_Gland_Neoplasm"                                                                                                                                         
 [3175] "Suicide"                                                                                                                                                              
 [3176] "Sunburn"                                                                                                                                                              
 [3177] "Superior_Vena_Cava_Syndrome"                                                                                                                                          
 [3178] "Supratentorial_Neoplasm"                                                                                                                                              
 [3179] "Sweat_Gland_Neoplasm"                                                                                                                                                 
 [3180] "Swelling"                                                                                                                                                             
 [3181] "Synovial_Sarcoma"                                                                                                                                                     
 [3182] "Diffuse_Giant_Cell_Tumor_of_Tendon_Sheath"                                                                                                                            
 [3183] "Giant_Cell_Tumor_of_Tendon_Sheath"                                                                                                                                    
 [3184] "Teratoma"                                                                                                                                                             
 [3185] "Testicular_Neoplasm"                                                                                                                                                  
 [3186] "Thecoma"                                                                                                                                                              
 [3187] "Thoracic_Neoplasm"                                                                                                                                                    
 [3188] "Essential_Thrombocythemia"                                                                                                                                            
 [3189] "Thrombocytopenia"                                                                                                                                                     
 [3190] "Thrombophlebitis"                                                                                                                                                     
 [3191] "Thymoma"                                                                                                                                                              
 [3192] "Thymic_Neoplasm"                                                                                                                                                      
 [3193] "Thyroid_Neoplasm"                                                                                                                                                     
 [3194] "Thyroid_Nodule"                                                                                                                                                       
 [3195] "Tongue_Neoplasm"                                                                                                                                                      
 [3196] "Tonsillar_Neoplasm"                                                                                                                                                   
 [3197] "Toxoplasmosis"                                                                                                                                                        
 [3198] "Tracheal_Neoplasm"                                                                                                                                                    
 [3199] "Chromosomal_Translocation"                                                                                                                                            
 [3200] "Trisomy"                                                                                                                                                              
 [3201] "Trophoblastic_Neoplasm"                                                                                                                                               
 [3202] "Tuberculosis"                                                                                                                                                         
 [3203] "Tuberous_Sclerosis"                                                                                                                                                   
 [3204] "Tumor_Lysis_Syndrome"                                                                                                                                                 
 [3205] "Ulcer"                                                                                                                                                                
 [3206] "Ureter_Neoplasm"                                                                                                                                                      
 [3207] "Urethra_Neoplasm"                                                                                                                                                     
 [3208] "Urinary_Incontinence"                                                                                                                                                 
 [3209] "Urinary_Tract_Disorder"                                                                                                                                               
 [3210] "Urinary_Tract_Neoplasm"                                                                                                                                               
 [3211] "Urticaria"                                                                                                                                                            
 [3212] "Urticaria_Pigmentosa_Maculopapular_Cutaneous_Mastocytosis"                                                                                                            
 [3213] "Uterine_Corpus_Leiomyoma"                                                                                                                                             
 [3214] "Uterine_Neoplasm"                                                                                                                                                     
 [3215] "Uveal_Neoplasm"                                                                                                                                                       
 [3216] "Vaginal_Neoplasm"                                                                                                                                                     
 [3217] "Vascular_Hamartoma"                                                                                                                                                   
 [3218] "Viral_Infection"                                                                                                                                                      
 [3219] "Vocal_Cord_Polyp"                                                                                                                                                     
 [3220] "Voice_Disorder"                                                                                                                                                       
 [3221] "Vomiting"                                                                                                                                                             
 [3222] "Vulvar_Neoplasm"                                                                                                                                                      
 [3223] "Wegener_s_Granulomatosis"                                                                                                                                             
 [3224] "Weight_Loss"                                                                                                                                                          
 [3225] "Idiopathic_Thrombocytopenic_Purpura"                                                                                                                                  
 [3226] "Werner_Syndrome"                                                                                                                                                      
 [3227] "Wiskott-Aldrich_Syndrome"                                                                                                                                             
 [3228] "Juvenile_Xanthogranuloma"                                                                                                                                             
 [3229] "Xeroderma_Pigmentosum"                                                                                                                                                
 [3230] "Zollinger_Ellison_Syndrome"                                                                                                                                           
 [3231] "Arachnoid_Cyst"                                                                                                                                                       
 [3232] "Infantile_Digital_Fibromatosis"                                                                                                                                       
 [3233] "B-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                                        
 [3234] "High-Grade_Lymphoma"                                                                                                                                                  
 [3235] "Intermediate-Grade_Lymphoma"                                                                                                                                          
 [3236] "Grade_3_Follicular_Lymphoma"                                                                                                                                          
 [3237] "Immunoblastic_Lymphoma"                                                                                                                                               
 [3238] "Low-Grade_Lymphoma"                                                                                                                                                   
 [3239] "Diffuse_Mixed_Cell_Lymphoma"                                                                                                                                          
 [3240] "Adult_Diffuse_Small_Cleaved_Cell_Lymphoma"                                                                                                                            
 [3241] "Grade_1_Follicular_Lymphoma"                                                                                                                                          
 [3242] "T-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                                        
 [3243] "Cutaneous_T-Cell_Lymphoma"                                                                                                                                            
 [3244] "Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                     
 [3245] "Palmar_Fibromatosis"                                                                                                                                                  
 [3246] "Granuloma_Annulare"                                                                                                                                                   
 [3247] "AIDS-Related_Lymphoma"                                                                                                                                                
 [3248] "Severe_Combined_Immunodeficiency"                                                                                                                                     
 [3249] "Choroid_Plexus_Neoplasm"                                                                                                                                              
 [3250] "Granular_Cell_Tumor"                                                                                                                                                  
 [3251] "Bone_Remodeling"                                                                                                                                                      
 [3252] "Li-Fraumeni_Syndrome"                                                                                                                                                 
 [3253] "Bacillary_Angiomatosis"                                                                                                                                               
 [3254] "Essential_Hypertension"                                                                                                                                               
 [3255] "Addiction"                                                                                                                                                            
 [3256] "Lobular_Capillary_Hemangioma"                                                                                                                                         
 [3257] "Spider_Nevus"                                                                                                                                                         
 [3258] "Metastatic_Carcinoma"                                                                                                                                                 
 [3259] "Chronic_Leukemia"                                                                                                                                                     
 [3260] "Breast_Adenosis"                                                                                                                                                      
 [3261] "Atonic_Epilepsy"                                                                                                                                                      
 [3262] "Epithelioid_Cell_Type_Gastrointestinal_Stromal_Tumor"                                                                                                                 
 [3263] "Therapy-Related_Neoplasm"                                                                                                                                             
 [3264] "WDHA_Syndrome"                                                                                                                                                        
 [3265] "Benign_Penile_Neoplasm"                                                                                                                                               
 [3266] "Lip_Carcinoma"                                                                                                                                                        
 [3267] "Cecum_Carcinoma"                                                                                                                                                      
 [3268] "Enzyme_Deficiency"                                                                                                                                                    
 [3269] "Squamous_Cell_Lung_Carcinoma"                                                                                                                                         
 [3270] "Bronchial_Adenoma"                                                                                                                                                    
 [3271] "Colon_Villous_Adenoma"                                                                                                                                                
 [3272] "Hypercalcemia_of_Malignancy"                                                                                                                                          
 [3273] "Lung_Hamartoma"                                                                                                                                                       
 [3274] "Ovarian_Fibroma"                                                                                                                                                      
 [3275] "Atrial_Myxoma"                                                                                                                                                        
 [3276] "Peripheral_Motor_Neuropathy"                                                                                                                                          
 [3277] "Peripheral_Sensory_Neuropathy"                                                                                                                                        
 [3278] "Thyroid_Adenoma"                                                                                                                                                      
 [3279] "Hypertensive_Encephalopathy"                                                                                                                                          
 [3280] "Endometrial_Disorder"                                                                                                                                                 
 [3281] "Granulomatous_Dermatitis"                                                                                                                                             
 [3282] "Adrenal_Cortex_Hyperplasia"                                                                                                                                           
 [3283] "Immune_System_Disorder"                                                                                                                                               
 [3284] "Injection_Site_Reaction"                                                                                                                                              
 [3285] "Genital_Leukoplakia"                                                                                                                                                  
 [3286] "Cutaneous_Melanoma"                                                                                                                                                   
 [3287] "Degenerated_Uterine_Corpus_Leiomyoma"                                                                                                                                 
 [3288] "Lung_Adenocarcinoma"                                                                                                                                                  
 [3289] "Esophageal_Carcinoma"                                                                                                                                                 
 [3290] "Hypertensive_Retinopathy"                                                                                                                                             
 [3291] "Galactocele"                                                                                                                                                          
 [3292] "Aneurysmal_Bone_Cyst"                                                                                                                                                 
 [3293] "Mixed_Cellularity_Hodgkin_s_Lymphoma"                                                                                                                                 
 [3294] "Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                                                 
 [3295] "Atypical_Chronic_Myeloid_Leukemia"                                                                                                                                    
 [3296] "Myeloid_Sarcoma"                                                                                                                                                      
 [3297] "Placental_Polyp"                                                                                                                                                      
 [3298] "Mammary_Duct_Ectasia"                                                                                                                                                 
 [3299] "Balanitis_Xerotica_Obliterans"                                                                                                                                        
 [3300] "Malignant_Posterior_Tongue_Neoplasm"                                                                                                                                  
 [3301] "Malignant_Parotid_Gland_Neoplasm"                                                                                                                                     
 [3302] "Malignant_Submandibular_Gland_Neoplasm"                                                                                                                               
 [3303] "Malignant_Sublingual_Gland_Neoplasm"                                                                                                                                  
 [3304] "Malignant_Hard_Palate_Neoplasm"                                                                                                                                       
 [3305] "Malignant_Soft_Palate_Neoplasm"                                                                                                                                       
 [3306] "Malignant_Palate_Neoplasm"                                                                                                                                            
 [3307] "Malignant_Pyriform_Fossa_Neoplasm"                                                                                                                                    
 [3308] "Malignant_Neoplasm_of_the_Thoracic_Esophagus"                                                                                                                         
 [3309] "Malignant_Neoplasm_of_the_Upper_Third_of_the_Esophagus"                                                                                                               
 [3310] "Malignant_Neoplasm_of_the_Middle_Third_of_the_Esophagus"                                                                                                              
 [3311] "Malignant_Neoplasm_of_the_Lower_Third_of_the_Esophagus"                                                                                                               
 [3312] "Malignant_Ampulla_of_Vater_Neoplasm"                                                                                                                                  
 [3313] "Malignant_Retroperitoneal_Neoplasm"                                                                                                                                   
 [3314] "Malignant_Peritoneal_Neoplasm"                                                                                                                                        
 [3315] "Malignant_Splenic_Neoplasm"                                                                                                                                           
 [3316] "Malignant_Maxillary_Sinus_Neoplasm"                                                                                                                                   
 [3317] "Malignant_Ethmoid_Sinus_Neoplasm"                                                                                                                                     
 [3318] "Malignant_Frontal_Sinus_Neoplasm"                                                                                                                                     
 [3319] "Malignant_Sphenoid_Sinus_Neoplasm"                                                                                                                                    
 [3320] "Malignant_Glottis_Neoplasm"                                                                                                                                           
 [3321] "Malignant_Supraglottis_Neoplasm"                                                                                                                                      
 [3322] "Malignant_Subglottis_Neoplasm"                                                                                                                                        
 [3323] "Malignant_Pleural_Neoplasm"                                                                                                                                           
 [3324] "Malignant_Cardiac_Neoplasm"                                                                                                                                           
 [3325] "Malignant_Mediastinal_Neoplasm"                                                                                                                                       
 [3326] "Skin_Kaposi_s_Sarcoma"                                                                                                                                                
 [3327] "Lung_Kaposi_s_Sarcoma"                                                                                                                                                
 [3328] "Malignant_Uterine_Neoplasm"                                                                                                                                           
 [3329] "Malignant_Endocervical_Neoplasm"                                                                                                                                      
 [3330] "Malignant_Exocervical_Neoplasm"                                                                                                                                       
 [3331] "Malignant_Placental_Neoplasm"                                                                                                                                         
 [3332] "Malignant_Uterine_Corpus_Neoplasm"                                                                                                                                    
 [3333] "Malignant_Clitoral_Neoplasm"                                                                                                                                          
 [3334] "Malignant_Epididymal_Neoplasm"                                                                                                                                        
 [3335] "Malignant_Spermatic_Cord_Neoplasm"                                                                                                                                    
 [3336] "Malignant_Scrotal_Neoplasm"                                                                                                                                           
 [3337] "Malignant_Paraurethral_Gland_Neoplasm"                                                                                                                                
 [3338] "Malignant_Orbit_Neoplasm"                                                                                                                                             
 [3339] "Malignant_Lacrimal_Gland_Neoplasm"                                                                                                                                    
 [3340] "Malignant_Conjunctival_Neoplasm"                                                                                                                                      
 [3341] "Malignant_Corneal_Neoplasm"                                                                                                                                           
 [3342] "Malignant_Choroid_Neoplasm"                                                                                                                                           
 [3343] "Malignant_Lacrimal_Duct_Neoplasm"                                                                                                                                     
 [3344] "Malignant_Brain_Neoplasm"                                                                                                                                             
 [3345] "Malignant_Cerebellar_Neoplasm"                                                                                                                                        
 [3346] "Malignant_Brain_Stem_Neoplasm"                                                                                                                                        
 [3347] "Malignant_Cranial_Nerve_Neoplasm"                                                                                                                                     
 [3348] "Malignant_Spinal_Cord_Neoplasm"                                                                                                                                       
 [3349] "Malignant_Pineal_Region_Neoplasm"                                                                                                                                     
 [3350] "Malignant_Carotid_Body_Paraganglioma"                                                                                                                                 
 [3351] "Malignant_Endocrine_Neoplasm"                                                                                                                                         
 [3352] "Malignant_Thoracic_Neoplasm"                                                                                                                                          
 [3353] "Metastatic_Neoplasm_to_the_Lung"                                                                                                                                      
 [3354] "Metastatic_Neoplasm_to_the_Mediastinum"                                                                                                                               
 [3355] "Metastatic_Neoplasm_to_the_Pleura"                                                                                                                                    
 [3356] "Metastatic_Neoplasm_to_the_Bone"                                                                                                                                      
 [3357] "Stage_III_Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                                       
 [3358] "Stage_III_Mixed_Cellularity_Hodgkin_s_Lymphoma"                                                                                                                       
 [3359] "Stage_III_Lymphocyte_Depleted_Hodgkin_s_Lymphoma"                                                                                                                     
 [3360] "Stage_III_Hodgkin_s_Lymphoma"                                                                                                                                         
 [3361] "Plasma_Cell_Leukemia_in_Remission"                                                                                                                                    
 [3362] "Acute_Lymphoblastic_Leukemia_in_Remission"                                                                                                                            
 [3363] "Chronic_Lymphocytic_Leukemia_in_Remission"                                                                                                                            
 [3364] "Acute_Myeloid_Leukemia_in_Remission"                                                                                                                                  
 [3365] "Chronic_Myelogenous_Leukemia_in_Remission"                                                                                                                            
 [3366] "Acute_Monocytic_Leukemia_in_Remission"                                                                                                                                
 [3367] "Benign_Lip_Neoplasm"                                                                                                                                                  
 [3368] "Benign_Tongue_Neoplasm"                                                                                                                                               
 [3369] "Benign_Floor_of_the_Mouth_Neoplasm"                                                                                                                                   
 [3370] "Benign_Tonsillar_Neoplasm"                                                                                                                                            
 [3371] "Benign_Nasopharyngeal_Neoplasm"                                                                                                                                       
 [3372] "Benign_Hypopharyngeal_Neoplasm"                                                                                                                                       
 [3373] "Benign_Pharyngeal_Neoplasm"                                                                                                                                           
 [3374] "Benign_Esophageal_Neoplasm"                                                                                                                                           
 [3375] "Benign_Gastric_Neoplasm"                                                                                                                                              
 [3376] "Benign_Small_Intestinal_Neoplasm"                                                                                                                                     
 [3377] "Benign_Laryngeal_Neoplasm"                                                                                                                                            
 [3378] "Benign_Tracheal_Neoplasm"                                                                                                                                             
 [3379] "Benign_Pleural_Neoplasm"                                                                                                                                              
 [3380] "Benign_Mediastinal_Neoplasm"                                                                                                                                          
 [3381] "Benign_Cardiac_Neoplasm"                                                                                                                                              
 [3382] "Spermatic_Cord_Lipoma"                                                                                                                                                
 [3383] "Benign_Cervical_Neoplasm"                                                                                                                                             
 [3384] "Benign_Uterine_Corpus_Neoplasm"                                                                                                                                       
 [3385] "Benign_Uterine_Neoplasm"                                                                                                                                              
 [3386] "Benign_Vaginal_Neoplasm"                                                                                                                                              
 [3387] "Benign_Vulvar_Neoplasm"                                                                                                                                               
 [3388] "Benign_Testicular_Neoplasm"                                                                                                                                           
 [3389] "Benign_Prostate_Neoplasm"                                                                                                                                             
 [3390] "Benign_Epididymal_Neoplasm"                                                                                                                                           
 [3391] "Benign_Scrotal_Neoplasm"                                                                                                                                              
 [3392] "Benign_Renal_Pelvis_Neoplasm"                                                                                                                                         
 [3393] "Benign_Ureter_Neoplasm"                                                                                                                                               
 [3394] "Benign_Bladder_Neoplasm"                                                                                                                                              
 [3395] "Benign_Urethral_Neoplasm"                                                                                                                                             
 [3396] "Benign_Orbit_Neoplasm"                                                                                                                                                
 [3397] "Benign_Lacrimal_Gland_Neoplasm"                                                                                                                                       
 [3398] "Benign_Conjunctival_Neoplasm"                                                                                                                                         
 [3399] "Benign_Corneal_Neoplasm"                                                                                                                                              
 [3400] "Benign_Retinal_Neoplasm"                                                                                                                                              
 [3401] "Benign_Choroid_Neoplasm"                                                                                                                                              
 [3402] "Benign_Lacrimal_Duct_Neoplasm"                                                                                                                                        
 [3403] "Benign_Spinal_Cord_Neoplasm"                                                                                                                                          
 [3404] "Benign_Thyroid_Neoplasm"                                                                                                                                              
 [3405] "Benign_Adrenal_Gland_Neoplasm"                                                                                                                                        
 [3406] "Benign_Parathyroid_Neoplasm"                                                                                                                                          
 [3407] "Benign_Pineal_Region_Neoplasm"                                                                                                                                        
 [3408] "Intracranial_Hemangioma"                                                                                                                                              
 [3409] "Retinal_Hemangioma"                                                                                                                                                   
 [3410] "Intra-Abdominal_Hemangioma"                                                                                                                                           
 [3411] "Benign_Lymph_Node_Neoplasm"                                                                                                                                           
 [3412] "Stage_0_Esophageal_Cancer"                                                                                                                                            
 [3413] "Stage_0_Colon_Cancer"                                                                                                                                                 
 [3414] "Tracheal_Carcinoma_in_situ"                                                                                                                                           
 [3415] "Stage_0_Skin_Cancer"                                                                                                                                                  
 [3416] "Stage_0_Breast_Cancer"                                                                                                                                                
 [3417] "Grade_III_Prostatic_Intraepithelial_Neoplasia"                                                                                                                        
 [3418] "Stage_0_Penile_Cancer"                                                                                                                                                
 [3419] "Stage_0is_Bladder_Cancer"                                                                                                                                             
 [3420] "Neoplasm_of_Uncertain_Malignant_Potential"                                                                                                                            
 [3421] "Cerebral_Cyst"                                                                                                                                                        
 [3422] "Conjunctival_Granuloma"                                                                                                                                               
 [3423] "Conjunctival_Cyst"                                                                                                                                                    
 [3424] "Eyelid_Xanthoma"                                                                                                                                                      
 [3425] "Eyelid_Cyst"                                                                                                                                                          
 [3426] "Orbital_Granuloma"                                                                                                                                                    
 [3427] "Middle_Ear_Cholesteatoma"                                                                                                                                             
 [3428] "Middle_Ear_Cholesterol_Granuloma"                                                                                                                                     
 [3429] "Benign_Essential_Hypertension"                                                                                                                                        
 [3430] "Secondary_Hypertension"                                                                                                                                               
 [3431] "Benign_Secondary_Hypertension"                                                                                                                                        
 [3432] "Polypoid_Sinus_Degeneration"                                                                                                                                          
 [3433] "Breast_Fibrosis"                                                                                                                                                      
 [3434] "Breast_Fat_Necrosis"                                                                                                                                                  
 [3435] "Uterine_Polyp"                                                                                                                                                        
 [3436] "Vaginal_Leukoplakia"                                                                                                                                                  
 [3437] "Vaginal_Polyp"                                                                                                                                                        
 [3438] "Late_Radiation_Injury"                                                                                                                                                
 [3439] "Traumatic_Neuroma"                                                                                                                                                    
 [3440] "Thyroid_Cyst"                                                                                                                                                         
 [3441] "Contact_Hypersensitivity"                                                                                                                                             
 [3442] "Malnutrition"                                                                                                                                                         
 [3443] "Parapsoriasis_en_Plaques"                                                                                                                                             
 [3444] "Injury"                                                                                                                                                               
 [3445] "Calcification"                                                                                                                                                        
 [3446] "Anhedonia"                                                                                                                                                            
 [3447] "Reproductive_System_Neoplasm"                                                                                                                                         
 [3448] "Obstructive_Uropathy"                                                                                                                                                 
 [3449] "Alteration_in_Respiration"                                                                                                                                            
 [3450] "Benign_Neoplasm"                                                                                                                                                      
 [3451] "Salivary_Gland_Basal_Cell_Adenocarcinoma"                                                                                                                             
 [3452] "Oxyphilic_Adenocarcinoma"                                                                                                                                             
 [3453] "Cribriform_Carcinoma"                                                                                                                                                 
 [3454] "Granular_Cell_Carcinoma"                                                                                                                                              
 [3455] "Tubular_Adenocarcinoma"                                                                                                                                               
 [3456] "Basal_Cell_Adenoma"                                                                                                                                                   
 [3457] "Thyroid_Follicular_Adenoma"                                                                                                                                           
 [3458] "Microcystic_Adenoma"                                                                                                                                                  
 [3459] "Salivary_Gland_Monomorphic_Adenoma"                                                                                                                                   
 [3460] "Papillary_Adenoma"                                                                                                                                                    
 [3461] "Trabecular_Adenoma"                                                                                                                                                   
 [3462] "Goblet_Cell_Carcinoid_Tumor"                                                                                                                                          
 [3463] "Anaplastic_Carcinoma"                                                                                                                                                 
 [3464] "Undifferentiated_Carcinoma"                                                                                                                                           
 [3465] "Carcinomatosis"                                                                                                                                                       
 [3466] "Dysplastic_Nevus"                                                                                                                                                     
 [3467] "Papillary_Fibroelastoma"                                                                                                                                              
 [3468] "Subependymal_Giant_Cell_Astrocytoma"                                                                                                                                  
 [3469] "Myxopapillary_Ependymoma"                                                                                                                                             
 [3470] "Choroid_Plexus_Papilloma"                                                                                                                                             
 [3471] "Intramuscular_Hemangioma"                                                                                                                                             
 [3472] "Epithelioid_Leiomyosarcoma"                                                                                                                                           
 [3473] "Myxoid_Leiomyosarcoma"                                                                                                                                                
 [3474] "Hibernoma"                                                                                                                                                            
 [3475] "Pleomorphic_Lipoma"                                                                                                                                                   
 [3476] "Dedifferentiated_Liposarcoma"                                                                                                                                         
 [3477] "Pleomorphic_Liposarcoma"                                                                                                                                              
 [3478] "Medullomyoblastoma"                                                                                                                                                   
 [3479] "Meningiomatosis"                                                                                                                                                      
 [3480] "Germ_Cell_Neoplasm"                                                                                                                                                   
 [3481] "Epithelial_Neoplasm"                                                                                                                                                  
 [3482] "Ameloblastic_Fibro-Odontoma"                                                                                                                                          
 [3483] "Compound_Odontoma"                                                                                                                                                    
 [3484] "Squamous_Cell_Papilloma"                                                                                                                                              
 [3485] "Papillomatosis"                                                                                                                                                       
 [3486] "Epithelioid_Sarcoma"                                                                                                                                                  
 [3487] "AIDS_Encephalopathy"                                                                                                                                                  
 [3488] "Neuroectodermal_Tumor"                                                                                                                                                
 [3489] "Infantile_Melanotic_Neuroectodermal_Neoplasm"                                                                                                                         
 [3490] "Wilms_Tumor-Aniridia-Genitourinary_Anomalies-Mental_Retardation_Syndrome"                                                                                             
 [3491] "Anaplastic_Large_Cell_Lymphoma"                                                                                                                                       
 [3492] "Lymphomatoid_Papulosis"                                                                                                                                               
 [3493] "Oral_Cavity_Hairy_Leukoplakia"                                                                                                                                        
 [3494] "Lymphatic_Vessel_Neoplasm"                                                                                                                                            
 [3495] "Cystic_Lymphangioma"                                                                                                                                                  
 [3496] "Lymphangiomyomatosis"                                                                                                                                                 
 [3497] "Adenomyoma"                                                                                                                                                           
 [3498] "Adenosquamous_Carcinoma"                                                                                                                                              
 [3499] "Hepatoblastoma"                                                                                                                                                       
 [3500] "Malignant_Mixed_Neoplasm"                                                                                                                                             
 [3501] "Mixed_Mesodermal_Mullerian_Tumor"                                                                                                                                     
 [3502] "Mesoblastic_Nephroma"                                                                                                                                                 
 [3503] "Pulmonary_Blastoma"                                                                                                                                                   
 [3504] "Angiolipoma"                                                                                                                                                          
 [3505] "Angiomyolipoma"                                                                                                                                                       
 [3506] "Myxoid_Liposarcoma"                                                                                                                                                   
 [3507] "Myelolipoma"                                                                                                                                                          
 [3508] "Mesenchymal_Chondrosarcoma"                                                                                                                                           
 [3509] "Giant_Cell_Tumor_of_Bone"                                                                                                                                             
 [3510] "Benign_Fibrous_Histiocytoma"                                                                                                                                          
 [3511] "Bone_Desmoplastic_Fibroma"                                                                                                                                            
 [3512] "Abdominal_Fibromatosis"                                                                                                                                               
 [3513] "Myofibromatosis"                                                                                                                                                      
 [3514] "Fibroepithelial_Neoplasm"                                                                                                                                             
 [3515] "Fibroadenoma"                                                                                                                                                         
 [3516] "Clear_Cell_Sarcoma_of_Soft_Parts"                                                                                                                                     
 [3517] "Small_Cell_Sarcoma"                                                                                                                                                   
 [3518] "Angiomyoma"                                                                                                                                                           
 [3519] "Leiomyomatosis"                                                                                                                                                       
 [3520] "Alveolar_Rhabdomyosarcoma"                                                                                                                                            
 [3521] "Alveolar_Soft_Part_Sarcoma"                                                                                                                                           
 [3522] "Smooth_Muscle_Neoplasm"                                                                                                                                               
 [3523] "Embryonal_Carcinoma"                                                                                                                                                  
 [3524] "Germinoma"                                                                                                                                                            
 [3525] "Gonadoblastoma"                                                                                                                                                       
 [3526] "Mixed_Embryonal_Carcinoma_and_Teratoma"                                                                                                                               
 [3527] "Placental-Site_Gestational_Trophoblastic_Tumor"                                                                                                                       
 [3528] "Hepatocellular_Adenoma"                                                                                                                                               
 [3529] "Oxyphilic_Adenoma"                                                                                                                                                    
 [3530] "Hidrocystoma"                                                                                                                                                         
 [3531] "Syringoma"                                                                                                                                                            
 [3532] "Adenomatoid_Tumor"                                                                                                                                                    
 [3533] "Pulmonary_Adenomatosis"                                                                                                                                               
 [3534] "Adenomatous_Polyp"                                                                                                                                                    
 [3535] "Cystic_Mesothelioma"                                                                                                                                                  
 [3536] "Clear_Cell_Adenocarcinoma"                                                                                                                                            
 [3537] "Sebaceous_Adenocarcinoma"                                                                                                                                             
 [3538] "Acinar_Cell_Carcinoma"                                                                                                                                                
 [3539] "Endometrioid_Carcinoma"                                                                                                                                               
 [3540] "Pancreatic_Endocrine_Carcinoma"                                                                                                                                       
 [3541] "Lobular_Breast_Carcinoma"                                                                                                                                             
 [3542] "Mucoepidermoid_Carcinoma"                                                                                                                                             
 [3543] "Neuroendocrine_Carcinoma"                                                                                                                                             
 [3544] "Signet_Ring_Cell_Carcinoma"                                                                                                                                           
 [3545] "Adnexal_Carcinoma"                                                                                                                                                    
 [3546] "Mucinous_Cystadenocarcinoma"                                                                                                                                          
 [3547] "Papillary_Cystadenocarcinoma"                                                                                                                                         
 [3548] "Serous_Cystadenocarcinoma"                                                                                                                                            
 [3549] "Giant_Cell_Carcinoma"                                                                                                                                                 
 [3550] "Large_Cell_Carcinoma"                                                                                                                                                 
 [3551] "Verrucous_Carcinoma"                                                                                                                                                  
 [3552] "Cervical_Intraepithelial_Neoplasia"                                                                                                                                   
 [3553] "Serous_Cystadenoma"                                                                                                                                                   
 [3554] "Basal_Cell_Neoplasm"                                                                                                                                                  
 [3555] "Intraductal_Papilloma"                                                                                                                                                
 [3556] "Mesothelial_Neoplasm"                                                                                                                                                 
 [3557] "Neuroepithelial_Neoplasm"                                                                                                                                             
 [3558] "Ganglioglioma"                                                                                                                                                        
 [3559] "Olfactory_Neuroblastoma"                                                                                                                                              
 [3560] "Ganglioneuroblastoma"                                                                                                                                                 
 [3561] "Neurocytoma"                                                                                                                                                          
 [3562] "Squamous_Cell_Neoplasm"                                                                                                                                               
 [3563] "Inverted_Papilloma"                                                                                                                                                   
 [3564] "Sex_Cord-Stromal_Tumor"                                                                                                                                               
 [3565] "Subependymoma"                                                                                                                                                        
 [3566] "Gliosarcoma"                                                                                                                                                          
 [3567] "Plexiform_Neurofibroma"                                                                                                                                               
 [3568] "Malignant_Peripheral_Nerve_Sheath_Tumor"                                                                                                                              
 [3569] "Angiofibroma"                                                                                                                                                         
 [3570] "Epithelioid_Hemangioendothelioma"                                                                                                                                     
 [3571] "Hemangioblastoma"                                                                                                                                                     
 [3572] "Amelanotic_Melanoma"                                                                                                                                                  
 [3573] "Blue_Nevus"                                                                                                                                                           
 [3574] "Intradermal_Nevus"                                                                                                                                                    
 [3575] "Calcifying_Odontogenic_Cyst"                                                                                                                                          
 [3576] "Rhabdoid_Tumor"                                                                                                                                                       
 [3577] "Neuroendocrine_Neoplasm"                                                                                                                                              
 [3578] "Connective_and_Soft_Tissue_Neoplasm"                                                                                                                                  
 [3579] "Malignant_Salivary_Gland_Neoplasm"                                                                                                                                    
 [3580] "Carcinoma_of_Unknown_Primary"                                                                                                                                         
 [3581] "Metastatic_Neoplasm_to_the_Brain"                                                                                                                                     
 [3582] "Metastasis_to_the_Leptomeninges"                                                                                                                                      
 [3583] "Malignant_Ascites"                                                                                                                                                    
 [3584] "Type_II_Achondrogenesis"                                                                                                                                              
 [3585] "Cerebrooculofacioskeletal_Syndrome"                                                                                                                                   
 [3586] "Secondary_Amyloidosis"                                                                                                                                                
 [3587] "Primary_Amyloidosis"                                                                                                                                                  
 [3588] "Cyclic_Neutropenia"                                                                                                                                                   
 [3589] "Hemangiomatosis_with_Thrombocytopenia"                                                                                                                                
 [3590] "X-Linked_Agammaglobulinemia"                                                                                                                                          
 [3591] "Systolic_Hypertension"                                                                                                                                                
 [3592] "Lesion"                                                                                                                                                               
 [3593] "Pseudolymphoma"                                                                                                                                                       
 [3594] "Juvenile_Polyp"                                                                                                                                                       
 [3595] "Nodular_Fasciitis"                                                                                                                                                    
 [3596] "Combined_Hepatocellular_Carcinoma_and_Cholangiocarcinoma"                                                                                                             
 [3597] "Benign_Synovial_Neoplasm"                                                                                                                                             
 [3598] "Chondromyxoid_Fibroma"                                                                                                                                                
 [3599] "Malaise"                                                                                                                                                              
 [3600] "Asymptomatic"                                                                                                                                                         
 [3601] "Ataxic_Gait"                                                                                                                                                          
 [3602] "Reflux"                                                                                                                                                               
 [3603] "Infertility"                                                                                                                                                          
 [3604] "Neurological_Signs_and_Symptoms"                                                                                                                                      
 [3605] "Diastolic_Hypertension"                                                                                                                                               
 [3606] "Pulmonary_Granuloma"                                                                                                                                                  
 [3607] "Port_Wine_Type_Hemangioma"                                                                                                                                            
 [3608] "Congenital_Hemangioma"                                                                                                                                                
 [3609] "Urothelial_Papilloma"                                                                                                                                                 
 [3610] "Malignant_Ovarian_Cyst"                                                                                                                                               
 [3611] "Gallbladder_Carcinoma"                                                                                                                                                
 [3612] "Neonatal_Leukemia"                                                                                                                                                    
 [3613] "Aggravated_Neurofibromatosis"                                                                                                                                         
 [3614] "Renal_Cell_Dysplasia"                                                                                                                                                 
 [3615] "Benign_Female_Breast_Neoplasm"                                                                                                                                        
 [3616] "Pancreatic_Carcinoma"                                                                                                                                                 
 [3617] "Aggravated_Malignant_Neoplasm"                                                                                                                                        
 [3618] "Menopausal_Symptoms"                                                                                                                                                  
 [3619] "Mucositis"                                                                                                                                                            
 [3620] "Whole_Blood_Atypical_Lymphocyte_Counts"                                                                                                                               
 [3621] "Simple_Ovarian_Cyst"                                                                                                                                                  
 [3622] "Ovarian_Dermoid_Cyst"                                                                                                                                                 
 [3623] "Laboratory_Finding"                                                                                                                                                   
 [3624] "Mental_and_Behavioral_Signs_and_Symptoms"                                                                                                                             
 [3625] "Pediatric_AIDS"                                                                                                                                                       
 [3626] "Extrahepatic_Bile_Duct_Carcinoma"                                                                                                                                     
 [3627] "Ependymal_Tumor_of_Brain"                                                                                                                                             
 [3628] "Male_Breast_Carcinoma"                                                                                                                                                
 [3629] "Intraductal_Breast_Papilloma"                                                                                                                                         
 [3630] "Colonic_Adenoma"                                                                                                                                                      
 [3631] "Epididymal_Cyst"                                                                                                                                                      
 [3632] "Esophageal_Leiomyoma"                                                                                                                                                 
 [3633] "Fallopian_Tube_Carcinoma"                                                                                                                                             
 [3634] "Gastrointestinal_Stromal_Tumor"                                                                                                                                       
 [3635] "Hepatic_Hemangioma"                                                                                                                                                   
 [3636] "Lymphangitic_Carcinomatosis"                                                                                                                                          
 [3637] "Nasopharyngeal_Carcinoma"                                                                                                                                             
 [3638] "Brenner_Tumor_of_the_Ovary"                                                                                                                                           
 [3639] "Ovarian_Germ_Cell_Tumor"                                                                                                                                              
 [3640] "Pancreatic_Cystadenocarcinoma"                                                                                                                                        
 [3641] "Spinal_Cord_Ependymoma"                                                                                                                                               
 [3642] "Gastric_Leiomyoma"                                                                                                                                                    
 [3643] "Testicular_Teratoma"                                                                                                                                                  
 [3644] "Anaplastic_Thyroid_Carcinoma"                                                                                                                                         
 [3645] "Medullary_Thyroid_Carcinoma"                                                                                                                                          
 [3646] "Eyelid_Nevus"                                                                                                                                                         
 [3647] "Leukoplakia_of_Gingiva"                                                                                                                                               
 [3648] "Ovarian_Mass"                                                                                                                                                         
 [3649] "Primary_Cerebral_Lymphoma"                                                                                                                                            
 [3650] "Skin_Cyst"                                                                                                                                                            
 [3651] "Testicular_Cyst"                                                                                                                                                      
 [3652] "Leukoplakia_of_Tongue"                                                                                                                                                
 [3653] "Vaginal_Cyst"                                                                                                                                                         
 [3654] "Renal_Angiomyolipoma"                                                                                                                                                 
 [3655] "Pelvic_Inflammatory_Disease"                                                                                                                                          
 [3656] "Hypoxia"                                                                                                                                                              
 [3657] "Color_Blindness"                                                                                                                                                      
 [3658] "Mu_Heavy_Chain_Disease"                                                                                                                                               
 [3659] "Drug_Dependence"                                                                                                                                                      
 [3660] "Bare_Lymphocyte_Syndrome"                                                                                                                                             
 [3661] "Minimal_Residual_Disease"                                                                                                                                             
 [3662] "Isochromosome"                                                                                                                                                        
 [3663] "Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue"                                                                                        
 [3664] "Hantavirus_Infection"                                                                                                                                                 
 [3665] "Compound_Nevus"                                                                                                                                                       
 [3666] "Telangiectatic_Osteosarcoma"                                                                                                                                          
 [3667] "Mixed_Glioma"                                                                                                                                                         
 [3668] "Papillary_Meningioma"                                                                                                                                                 
 [3669] "Radiation_Enteritis"                                                                                                                                                  
 [3670] "Adrenal_Gland_Adenoma"                                                                                                                                                
 [3671] "Borderline_Hypertension"                                                                                                                                              
 [3672] "Ampulla_of_Vater_Carcinoma"                                                                                                                                           
 [3673] "Gallbladder_Polyp"                                                                                                                                                    
 [3674] "Molecular_Abnormality"                                                                                                                                                
 [3675] "Stage_IA_Hodgkin_s_Lymphoma"                                                                                                                                          
 [3676] "Stage_IIA_Hodgkin_s_Lymphoma"                                                                                                                                         
 [3677] "Stage_IIB_Hodgkin_s_Lymphoma"                                                                                                                                         
 [3678] "Stage_IIIA_Hodgkin_s_Lymphoma"                                                                                                                                        
 [3679] "Small_Cell_Carcinoma"                                                                                                                                                 
 [3680] "Parathyroid_Adenoma"                                                                                                                                                  
 [3681] "Vaginal_Carcinoma"                                                                                                                                                    
 [3682] "Extragonadal_Germ_Cell_Neoplasm"                                                                                                                                      
 [3683] "Suppurative_Granuloma"                                                                                                                                                
 [3684] "Parapsoriasis_Lichenoides"                                                                                                                                            
 [3685] "Small_Plaque_Parapsoriasis"                                                                                                                                           
 [3686] "Large_Plaque_Parapsoriasis"                                                                                                                                           
 [3687] "Cutis_Marmorata"                                                                                                                                                      
 [3688] "Becker_s_Nevus"                                                                                                                                                       
 [3689] "Angioma_Serpiginosum"                                                                                                                                                 
 [3690] "Angiokeratoma_of_Mibelli"                                                                                                                                             
 [3691] "Knuckle_Pads"                                                                                                                                                         
 [3692] "Nasal_Sinus_Cyst"                                                                                                                                                     
 [3693] "Paranasal_Sinus_Mucocele"                                                                                                                                             
 [3694] "Maxillary_Sinus_Polyp"                                                                                                                                                
 [3695] "Ethmoid_Sinus_Polyp"                                                                                                                                                  
 [3696] "Sphenoid_Sinus_Polyp"                                                                                                                                                 
 [3697] "Pharyngeal_Cyst"                                                                                                                                                      
 [3698] "Leukoplakia_of_Vocal_Cords"                                                                                                                                           
 [3699] "Endocrine_Hypertension"                                                                                                                                               
 [3700] "Non-Neoplastic_Nevus"                                                                                                                                                 
 [3701] "Turcot_Syndrome"                                                                                                                                                      
 [3702] "Bannayan_Syndrome"                                                                                                                                                    
 [3703] "Hereditary_Benign_Intraepithelial_Dyskeratosis"                                                                                                                       
 [3704] "Fibrous_Hamartoma_of_Infancy"                                                                                                                                         
 [3705] "Nevus_Anemicus"                                                                                                                                                       
 [3706] "Congenital_Melanocytic_Skin_Nevus"                                                                                                                                    
 [3707] "Mongolian_Spot"                                                                                                                                                       
 [3708] "Nevus_Comedonicus"                                                                                                                                                    
 [3709] "Third_Ventricle_Colloid_Cyst"                                                                                                                                         
 [3710] "Gingival_Polyp"                                                                                                                                                       
 [3711] "Benign_Lymphoepithelial_Lesion_of_the_Salivary_Gland"                                                                                                                 
 [3712] "Oral_Mucosa_Lobular_Capillary_Hemangioma"                                                                                                                             
 [3713] "Leukoplakia_of_Lips"                                                                                                                                                  
 [3714] "Hairy_Leukoplakia_of_Tongue"                                                                                                                                          
 [3715] "Esophageal_Leukoplakia"                                                                                                                                               
 [3716] "Gastric_Polyp"                                                                                                                                                        
 [3717] "Gastric_Intraepithelial_Neoplasia"                                                                                                                                    
 [3718] "Intestinal_Metaplasia_of_Gastric_Mucosa"                                                                                                                              
 [3719] "Anal_Polyp"                                                                                                                                                           
 [3720] "Leiomyomatosis_Peritonealis_Disseminata"                                                                                                                              
 [3721] "Liver_and_Biliary_Tract_Disorder"                                                                                                                                     
 [3722] "Hepatic_Cyst"                                                                                                                                                         
 [3723] "Hyperuricemia"                                                                                                                                                        
 [3724] "Adenosine_Deaminase_Deficiency"                                                                                                                                       
 [3725] "Purine-Nucleoside_Phosphorylase_Deficiency"                                                                                                                           
 [3726] "Thymine-Uraciluria"                                                                                                                                                   
 [3727] "Xeroderma_Pigmentosum_Complementation_Group_A"                                                                                                                        
 [3728] "Xeroderma_Pigmentosum_Complementation_Group_B"                                                                                                                        
 [3729] "Xeroderma_Pigmentosum_Complementation_Group_D"                                                                                                                        
 [3730] "Xeroderma_Pigmentosum_Complementation_Group_F"                                                                                                                        
 [3731] "Xeroderma_Pigmentosum_Complementation_Group_G"                                                                                                                        
 [3732] "Renal_Cyst"                                                                                                                                                           
 [3733] "Urethral_Cyst"                                                                                                                                                        
 [3734] "Prostate_Fibroma"                                                                                                                                                     
 [3735] "Ovarian_Germinal_Inclusion_Cyst"                                                                                                                                      
 [3736] "Squamous_Metaplasia_of_Cervix"                                                                                                                                        
 [3737] "Cervical_Atypia"                                                                                                                                                      
 [3738] "Cervical_Leukoplakia"                                                                                                                                                 
 [3739] "Uterine_Cervix_Cyst"                                                                                                                                                  
 [3740] "Vulvar_Polyp"                                                                                                                                                         
 [3741] "Spinal_Meningeal_Cyst"                                                                                                                                                
 [3742] "Visual_Epilepsy"                                                                                                                                                      
 [3743] "Paraneoplastic_Polyneuropathy"                                                                                                                                        
 [3744] "Iris_Cyst"                                                                                                                                                            
 [3745] "Iris_Idiopathic_Cyst"                                                                                                                                                 
 [3746] "Iris_Exudative_Cyst"                                                                                                                                                  
 [3747] "Ciliary_Body_Cyst"                                                                                                                                                    
 [3748] "Ciliary_Body_Idiopathic_Cyst"                                                                                                                                         
 [3749] "Eyelid_Sebaceous_Cyst"                                                                                                                                                
 [3750] "Inappropriate_Antidiuretic_Hormone_Secretion_Syndrome"                                                                                                                
 [3751] "Parathyroid_Hyperplasia"                                                                                                                                              
 [3752] "Hyperimmunoglobulin_M_Syndrome"                                                                                                                                       
 [3753] "Thrombocytopenia_Due_to_Immune_Destruction"                                                                                                                           
 [3754] "AIDS-Related_Kaposi_s_Sarcoma"                                                                                                                                        
 [3755] "Stage_II_Colon_Cancer"                                                                                                                                                
 [3756] "Stage_IV_Colon_Cancer"                                                                                                                                                
 [3757] "Stage_IV_Breast_Cancer"                                                                                                                                               
 [3758] "Monoclonal_Gammopathy_of_Undetermined_Significance"                                                                                                                   
 [3759] "Childhood_Medulloblastoma"                                                                                                                                            
 [3760] "Recurrent_Colon_Cancer"                                                                                                                                               
 [3761] "Recurrent_Esophageal_Cancer"                                                                                                                                          
 [3762] "Stage_0_Cervical_Cancer"                                                                                                                                              
 [3763] "Inflammatory_Breast_Carcinoma"                                                                                                                                        
 [3764] "Extramedullary_Plasmacytoma"                                                                                                                                          
 [3765] "Stage_IV_Renal_Cell_Cancer"                                                                                                                                           
 [3766] "Gastric_Adenocarcinoma"                                                                                                                                               
 [3767] "Malignant_Childhood_Neoplasm"                                                                                                                                         
 [3768] "Stage_IV_Endometrial_Cancer"                                                                                                                                          
 [3769] "Small_Intestinal_Lymphoma"                                                                                                                                            
 [3770] "Recurrent_Gallbladder_Carcinoma"                                                                                                                                      
 [3771] "Non-Functioning_Pituitary_Gland_Neoplasm"                                                                                                                             
 [3772] "Adult_Craniopharyngioma"                                                                                                                                              
 [3773] "Adult_Medulloblastoma"                                                                                                                                                
 [3774] "Stage_IV_Non-Small_Cell_Lung_Cancer"                                                                                                                                  
 [3775] "Malignant_Head_and_Neck_Neoplasm"                                                                                                                                     
 [3776] "Adult_Oligodendroglioma"                                                                                                                                              
 [3777] "Metastatic_Neoplasm_to_the_Central_Nervous_System"                                                                                                                    
 [3778] "Malignant_Bone_Neoplasm"                                                                                                                                              
 [3779] "Ductal_Breast_Carcinoma"                                                                                                                                              
 [3780] "Lobular_Carcinoma_in_situ_of_the_Breast"                                                                                                                              
 [3781] "Paget_s_Disease_and_Intraductal_Carcinoma_of_the_Breast"                                                                                                              
 [3782] "Fibroblastic_Osteosarcoma"                                                                                                                                            
 [3783] "Chondrosarcomatous_Osteosarcoma"                                                                                                                                      
 [3784] "Acral_Lentiginous_Malignant_Melanoma"                                                                                                                                 
 [3785] "Small_Cell_Osteosarcoma"                                                                                                                                              
 [3786] "Esophageal_Squamous_Cell_Carcinoma"                                                                                                                                   
 [3787] "Esophageal_Adenocarcinoma"                                                                                                                                            
 [3788] "Ovarian_Mucinous_Cystadenocarcinoma"                                                                                                                                  
 [3789] "Vulvar_Paget_s_Disease"                                                                                                                                               
 [3790] "Cervical_Squamous_Cell_Carcinoma"                                                                                                                                     
 [3791] "Cervical_Adenocarcinoma"                                                                                                                                              
 [3792] "Urothelial_Transitional_Cell_Carcinoma"                                                                                                                               
 [3793] "Bladder_Squamous_Cell_Carcinoma"                                                                                                                                      
 [3794] "Bladder_Adenocarcinoma"                                                                                                                                               
 [3795] "Conventional_Clear_Cell_Renal_Cell_Carcinoma"                                                                                                                         
 [3796] "Recurrent_Laryngeal_Carcinoma"                                                                                                                                        
 [3797] "Papillary_Thyroid_Carcinoma"                                                                                                                                          
 [3798] "Refractory_Anemia_with_Ringed_Sideroblasts"                                                                                                                           
 [3799] "Acute_Myeloid_Leukemia_with_Multilineage_Dysplasia_following_Myelodysplastic_Syndrome"                                                                                
 [3800] "Lung_Carcinoid_Tumor"                                                                                                                                                 
 [3801] "Adenocarcinoma_of_Unknown_Primary"                                                                                                                                    
 [3802] "Buccal_Mucosa_Squamous_Cell_Carcinoma"                                                                                                                                
 [3803] "Floor_of_Mouth_Squamous_Cell_Carcinoma"                                                                                                                               
 [3804] "Lip_Squamous_Cell_Carcinoma"                                                                                                                                          
 [3805] "Hypopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                               
 [3806] "Laryngeal_Squamous_Cell_Carcinoma"                                                                                                                                    
 [3807] "Childhood_Oligodendroglioma"                                                                                                                                          
 [3808] "AIDS-Related_Malignant_Neoplasm"                                                                                                                                      
 [3809] "Pilocytic_Astrocytoma"                                                                                                                                                
 [3810] "Childhood_Pilocytic_Astrocytoma"                                                                                                                                      
 [3811] "Anaplastic_Ependymoma"                                                                                                                                                
 [3812] "Mixed_Astrocytoma-Oligodendroglioma"                                                                                                                                  
 [3813] "Anaplastic_Malignant_Meningioma"                                                                                                                                      
 [3814] "Vulvar_Squamous_Cell_Carcinoma"                                                                                                                                       
 [3815] "Drug_Extravasation"                                                                                                                                                   
 [3816] "Anal_Condyloma_Acuminatum"                                                                                                                                            
 [3817] "Benign_Meningioma"                                                                                                                                                    
 [3818] "Cervical_Metaplasia"                                                                                                                                                  
 [3819] "Esophageal_Polyp"                                                                                                                                                     
 [3820] "Stage_IIIB_Hodgkin_s_Lymphoma"                                                                                                                                        
 [3821] "Stage_IVA_Hodgkin_s_Lymphoma"                                                                                                                                         
 [3822] "Ovarian_Cystadenoma"                                                                                                                                                  
 [3823] "Eyelid_Papilloma"                                                                                                                                                     
 [3824] "Leukostasis"                                                                                                                                                          
 [3825] "Myomatous_Neoplasm"                                                                                                                                                   
 [3826] "Prostatic_Intraepithelial_Neoplasia"                                                                                                                                  
 [3827] "Ectopic_Hormone_Secretion_Syndromes_Associated_with_Neoplasia"                                                                                                        
 [3828] "Trabecular_Adenocarcinoma"                                                                                                                                            
 [3829] "Ovarian_Endometriotic_Cyst"                                                                                                                                           
 [3830] "Lentigo_Simplex"                                                                                                                                                      
 [3831] "Xanthoma"                                                                                                                                                             
 [3832] "Mesonephric_Adenocarcinoma"                                                                                                                                           
 [3833] "Meningeal_Sarcoma"                                                                                                                                                    
 [3834] "Centroblastic_Lymphoma"                                                                                                                                               
 [3835] "Morton_s_Neuroma"                                                                                                                                                     
 [3836] "Isosporiasis"                                                                                                                                                         
 [3837] "Redness"                                                                                                                                                              
 [3838] "Perforation"                                                                                                                                                          
 [3839] "Lipogranuloma"                                                                                                                                                        
 [3840] "Cholesterol_Granuloma"                                                                                                                                                
 [3841] "Hyperplastic_Polyp"                                                                                                                                                   
 [3842] "Pale_Clear_Cell_Acanthoma"                                                                                                                                            
 [3843] "Dysplasia"                                                                                                                                                            
 [3844] "Isolated_Follicular_Keratosis"                                                                                                                                        
 [3845] "Epidermal_Nevus"                                                                                                                                                      
 [3846] "Polyposis"                                                                                                                                                            
 [3847] "Malignant_Giant_Cell_Neoplasm"                                                                                                                                        
 [3848] "Benign_Epithelial_Neoplasm"                                                                                                                                           
 [3849] "Benign_Epithelioma"                                                                                                                                                   
 [3850] "Pleomorphic_Carcinoma"                                                                                                                                                
 [3851] "Small_Cell_Intermediate_Cell_Carcinoma"                                                                                                                               
 [3852] "Verrucous_Papilloma"                                                                                                                                                  
 [3853] "Papillary_Squamous_Cell_Carcinoma"                                                                                                                                    
 [3854] "Metastatic_Squamous_Cell_Carcinoma"                                                                                                                                   
 [3855] "Keratinizing_Squamous_Cell_Carcinoma"                                                                                                                                 
 [3856] "Pseudoglandular_Squamous_Cell_Carcinoma"                                                                                                                              
 [3857] "Nasopharyngeal_Type_Undifferentiated_Carcinoma"                                                                                                                       
 [3858] "Superficial_Multifocal_Basal_Cell_Carcinoma"                                                                                                                          
 [3859] "Fibroepithelioma_of_Pinkus"                                                                                                                                           
 [3860] "Intraepidermal_Epithelioma_of_Jadassohn"                                                                                                                              
 [3861] "Trichoepithelioma"                                                                                                                                                    
 [3862] "Trichofolliculoma"                                                                                                                                                    
 [3863] "Trichilemmoma"                                                                                                                                                        
 [3864] "Pilomatrix_Carcinoma"                                                                                                                                                 
 [3865] "Transitional_Cell_Papilloma"                                                                                                                                          
 [3866] "Stage_0_Transitional_Cell_Carcinoma"                                                                                                                                  
 [3867] "Schneiderian_Papilloma"                                                                                                                                               
 [3868] "Inverted_Transitional_Cell_Papilloma"                                                                                                                                 
 [3869] "Schneiderian_Carcinoma"                                                                                                                                               
 [3870] "Sarcomatoid_Transitional_Cell_Carcinoma"                                                                                                                              
 [3871] "Basaloid_Carcinoma"                                                                                                                                                   
 [3872] "Papillary_Transitional_Cell_Carcinoma"                                                                                                                                
 [3873] "Adenocarcinoma_in_situ"                                                                                                                                               
 [3874] "Metastatic_Adenocarcinoma"                                                                                                                                            
 [3875] "Superficial_Spreading_Adenocarcinoma"                                                                                                                                 
 [3876] "Intestinal_Type_Adenocarcinoma"                                                                                                                                       
 [3877] "Diffuse_Type_Adenocarcinoma"                                                                                                                                          
 [3878] "Bile_Duct_Cystadenoma"                                                                                                                                                
 [3879] "Biliary_Cystadenocarcinoma"                                                                                                                                           
 [3880] "Fibrolamellar_Hepatocellular_Carcinoma"                                                                                                                               
 [3881] "Tubular_Adenoma"                                                                                                                                                      
 [3882] "Adenocarcinoma_in_Adenomatous_Polyposis_Coli"                                                                                                                         
 [3883] "Multiple_Adenomatous_Polyps"                                                                                                                                          
 [3884] "Adenocarcinoma_in_Multiple_Adenomatous_Polyps"                                                                                                                        
 [3885] "Solid_Carcinoma"                                                                                                                                                      
 [3886] "Appendix_Carcinoid_Tumor"                                                                                                                                             
 [3887] "Combined_Carcinoid_and_Adenocarcinoma"                                                                                                                                
 [3888] "Alveolar_Adenoma"                                                                                                                                                     
 [3889] "Adenocarcinoma_in_Villous_Adenoma"                                                                                                                                    
 [3890] "Villous_Adenocarcinoma"                                                                                                                                               
 [3891] "Tubulovillous_Adenoma"                                                                                                                                                
 [3892] "Adenocarcinoma_in_situ_in_Tubulovillous_Adenoma"                                                                                                                      
 [3893] "Adenocarcinoma_in_Tubulovillous_Adenoma"                                                                                                                              
 [3894] "Chromophobe_Renal_Cell_Carcinoma"                                                                                                                                     
 [3895] "Acidophil_Adenocarcinoma"                                                                                                                                             
 [3896] "Mixed_Acidophil-Basophil_Adenoma"                                                                                                                                     
 [3897] "Mixed_Acidophil-Basophil_Carcinoma"                                                                                                                                   
 [3898] "Basophilic_Adenocarcinoma"                                                                                                                                            
 [3899] "Clear_Cell_Adenoma"                                                                                                                                                   
 [3900] "Lipid-Rich_Carcinoma"                                                                                                                                                 
 [3901] "Glycogen-Rich_Carcinoma"                                                                                                                                              
 [3902] "Parathyroid_Chief_Cell_Adenoma"                                                                                                                                       
 [3903] "Water-Clear_Cell_Adenoma"                                                                                                                                             
 [3904] "Water-Clear_Cell_Adenocarcinoma"                                                                                                                                      
 [3905] "Mixed_Cell_Adenoma"                                                                                                                                                   
 [3906] "Mixed_Cell_Adenocarcinoma"                                                                                                                                            
 [3907] "Lipoadenoma"                                                                                                                                                          
 [3908] "Microfollicular_Adenoma"                                                                                                                                              
 [3909] "Macrofollicular_Adenoma"                                                                                                                                              
 [3910] "Juxtaglomerular_Cell_Tumor"                                                                                                                                           
 [3911] "Compact_Cell_Adrenal_Cortical_Adenoma"                                                                                                                                
 [3912] "Heavily_Pigmented_Adrenal_Cortical_Adenoma"                                                                                                                           
 [3913] "Clear_Cell_Adrenal_Cortical_Adenoma"                                                                                                                                  
 [3914] "Glomerulosa_Cell_Adrenal_Cortical_Adenoma"                                                                                                                            
 [3915] "Mixed_Cell_Adrenal_Cortical_Adenoma"                                                                                                                                  
 [3916] "Apocrine_Adenoma"                                                                                                                                                     
 [3917] "Apocrine_Carcinoma"                                                                                                                                                   
 [3918] "Eccrine_Spiradenoma"                                                                                                                                                  
 [3919] "Papillary_Hidradenoma_Hidradenoma_Papilliferum"                                                                                                                       
 [3920] "Papillary_Syringadenoma_Syringocystadenoma_Papilliferum"                                                                                                              
 [3921] "Papillary_Eccrine_Adenoma"                                                                                                                                            
 [3922] "Sebaceous_Adenoma"                                                                                                                                                    
 [3923] "Ceruminous_Adenoma"                                                                                                                                                   
 [3924] "Ceruminous_Adenocarcinoma"                                                                                                                                            
 [3925] "Borderline_Serous_Cystadenoma"                                                                                                                                        
 [3926] "Borderline_Papillary_Cystadenoma"                                                                                                                                     
 [3927] "Papillary_Cystic_Neoplasm"                                                                                                                                            
 [3928] "Papillary_Serous_Cystadenoma"                                                                                                                                         
 [3929] "Serous_Surface_Papilloma"                                                                                                                                             
 [3930] "Serous_Surface_Papillary_Carcinoma"                                                                                                                                   
 [3931] "Borderline_Papillary_Serous_Cystadenoma"                                                                                                                              
 [3932] "Papillary_Mucinous_Cystadenoma"                                                                                                                                       
 [3933] "Borderline_Mucinous_Cystadenoma"                                                                                                                                      
 [3934] "Borderline_Papillary_Mucinous_Cystadenoma"                                                                                                                            
 [3935] "Comedocarcinoma"                                                                                                                                                      
 [3936] "Secretory_Breast_Carcinoma"                                                                                                                                           
 [3937] "Intraductal_Papillary_Breast_Carcinoma"                                                                                                                               
 [3938] "Intracystic_Papilloma"                                                                                                                                                
 [3939] "Nipple_Adenoma"                                                                                                                                                       
 [3940] "Medullary_Carcinoma_with_Amyloid_Stroma"                                                                                                                              
 [3941] "Invasive_Ductal_Carcinoma_not_Otherwise_Specified"                                                                                                                    
 [3942] "Ductal_Carcinoma_in_situ_and_Lobular_Carcinoma_in_situ"                                                                                                               
 [3943] "Acinar_Cell_Adenoma"                                                                                                                                                  
 [3944] "Acinar_Cell_Neoplasm"                                                                                                                                                 
 [3945] "Complex_Epithelial_Neoplasm"                                                                                                                                          
 [3946] "Epithelial-Myoepithelial_Carcinoma"                                                                                                                                   
 [3947] "Adenocarcinoma_with_Squamous_Metaplasia"                                                                                                                              
 [3948] "Adenocarcinoma_with_Spindle_Cell_Metaplasia"                                                                                                                          
 [3949] "Adenocarcinoma_with_Apocrine_Metaplasia"                                                                                                                              
 [3950] "Luteinized_Thecoma"                                                                                                                                                   
 [3951] "Ovarian_Sclerosing_Stromal_Tumor"                                                                                                                                     
 [3952] "Malignant_Granulosa_Cell_Tumor"                                                                                                                                       
 [3953] "Granulosa_Cell-Theca_Cell_Tumor"                                                                                                                                      
 [3954] "Juvenile_Granulosa_Cell_Tumor"                                                                                                                                        
 [3955] "Sex_Cord_Tumor_with_Annular_Tubules"                                                                                                                                  
 [3956] "Benign_Androblastoma"                                                                                                                                                 
 [3957] "Malignant_Androblastoma"                                                                                                                                              
 [3958] "Tubular_Androblastoma_with_Lipid_Storage"                                                                                                                             
 [3959] "Benign_Leydig_Cell_Tumor"                                                                                                                                             
 [3960] "Malignant_Leydig_Cell_Tumor"                                                                                                                                          
 [3961] "Hilar_Cell_Tumor"                                                                                                                                                     
 [3962] "Steroid_Cell_Tumor_of_the_Ovary"                                                                                                                                      
 [3963] "Sympathetic_Paraganglioma"                                                                                                                                            
 [3964] "Parasympathetic_Paraganglioma"                                                                                                                                        
 [3965] "Aortic_Body_Paraganglioma"                                                                                                                                            
 [3966] "Malignant_Extra-Adrenal_Paraganglioma"                                                                                                                                
 [3967] "Malignant_Pheochromocytoma"                                                                                                                                           
 [3968] "Malignant_Glomus_Tumor"                                                                                                                                               
 [3969] "Glomangioma"                                                                                                                                                          
 [3970] "Glomangiomyoma"                                                                                                                                                       
 [3971] "Melanoma_in_situ"                                                                                                                                                     
 [3972] "Nodular_Melanoma"                                                                                                                                                     
 [3973] "Balloon_Cell_Nevus"                                                                                                                                                   
 [3974] "Balloon_Cell_Malignant_Skin_Melanoma"                                                                                                                                 
 [3975] "Regressing_Melanoma"                                                                                                                                                  
 [3976] "Neuronevus"                                                                                                                                                           
 [3977] "Melanocytoma_of_the_Eyeball"                                                                                                                                          
 [3978] "Junction_Nevus"                                                                                                                                                       
 [3979] "Melanoma_in_Junctional_Nevus"                                                                                                                                         
 [3980] "Precancerous_Melanosis"                                                                                                                                               
 [3981] "Giant_Pigmented_Nevus"                                                                                                                                                
 [3982] "Skin_Melanoma_in_Giant_Pigmented_Nevus"                                                                                                                               
 [3983] "Epithelioid_Cell_Melanoma"                                                                                                                                            
 [3984] "Spindle_Cell_Melanoma"                                                                                                                                                
 [3985] "Type_A_Spindle_Cell_Melanoma"                                                                                                                                         
 [3986] "Type_B_Spindle_Cell_Melanoma"                                                                                                                                         
 [3987] "Blue_Nevus-Like_Melanoma"                                                                                                                                             
 [3988] "Cellular_Blue_Nevus"                                                                                                                                                  
 [3989] "Benign_Soft_Tissue_Neoplasm"                                                                                                                                          
 [3990] "Sarcomatosis"                                                                                                                                                         
 [3991] "Infantile_Fibrosarcoma"                                                                                                                                               
 [3992] "Elastofibroma"                                                                                                                                                        
 [3993] "Atypical_Fibroxanthoma"                                                                                                                                               
 [3994] "Malignant_Fibrous_Histiocytoma"                                                                                                                                       
 [3995] "Lipomatous_Neoplasm"                                                                                                                                                  
 [3996] "Fibrolipoma"                                                                                                                                                          
 [3997] "Well-Differentiated_Liposarcoma"                                                                                                                                      
 [3998] "Fibromyxolipoma"                                                                                                                                                      
 [3999] "Round_Cell_Liposarcoma"                                                                                                                                               
 [4000] "Mixed_Liposarcoma"                                                                                                                                                    
 [4001] "Spindle_Cell_Lipoma"                                                                                                                                                  
 [4002] "Lipoblastomatosis"                                                                                                                                                    
 [4003] "Cellular_Leiomyoma"                                                                                                                                                   
 [4004] "Bizarre_Leiomyoma"                                                                                                                                                    
 [4005] "Pleomorphic_Rhabdomyosarcoma"                                                                                                                                         
 [4006] "Mixed_Type_Rhabdomyosarcoma"                                                                                                                                          
 [4007] "Fetal_Rhabdomyoma"                                                                                                                                                    
 [4008] "Adult_Rhabdomyoma"                                                                                                                                                    
 [4009] "Endometrial_Stromal_Nodule"                                                                                                                                           
 [4010] "Low_Grade_Endometrial_Stromal_Sarcoma"                                                                                                                                
 [4011] "Clear_Cell_Sarcoma_of_the_Kidney"                                                                                                                                     
 [4012] "Pancreatoblastoma"                                                                                                                                                    
 [4013] "Benign_Mesenchymoma"                                                                                                                                                  
 [4014] "Malignant_Mesenchymoma"                                                                                                                                               
 [4015] "Malignant_Brenner_Tumor"                                                                                                                                              
 [4016] "Intracanalicular_Fibroadenoma"                                                                                                                                        
 [4017] "Pericanalicular_Fibroadenoma"                                                                                                                                         
 [4018] "Giant_Fibroadenoma"                                                                                                                                                   
 [4019] "Benign_Phyllodes_Tumor"                                                                                                                                               
 [4020] "Malignant_Phyllodes_Tumor"                                                                                                                                            
 [4021] "Juvenile_Fibroadenoma"                                                                                                                                                
 [4022] "Synovial_Sarcoma_with_Spindle_Cell_Components"                                                                                                                        
 [4023] "Epithelioid_Synovial_Sarcoma"                                                                                                                                         
 [4024] "Biphasic_Synovial_Sarcoma"                                                                                                                                            
 [4025] "Benign_Mesothelioma"                                                                                                                                                  
 [4026] "Localized_Benign_Fibrous_Mesothelioma"                                                                                                                                
 [4027] "Mixed_Mesothelioma"                                                                                                                                                   
 [4028] "Spermatocytic_Seminoma"                                                                                                                                               
 [4029] "Polyembryoma"                                                                                                                                                         
 [4030] "Immature_Teratoma"                                                                                                                                                    
 [4031] "Undifferentiated_Immature_Teratoma"                                                                                                                                   
 [4032] "Intermediate_Immature_Teratoma"                                                                                                                                       
 [4033] "Teratoma_with_Malignant_Transformation"                                                                                                                               
 [4034] "Mixed_Germ_Cell_Neoplasm"                                                                                                                                             
 [4035] "Malignant_Struma_Ovarii"                                                                                                                                              
 [4036] "Strumal_Carcinoid_Neoplasm"                                                                                                                                           
 [4037] "Partial_Hydatidiform_Mole"                                                                                                                                            
 [4038] "Benign_Mesonephroma"                                                                                                                                                  
 [4039] "Mesonephric_Neoplasm"                                                                                                                                                 
 [4040] "Venous_Hemangioma"                                                                                                                                                    
 [4041] "Arteriovenous_Hemangioma"                                                                                                                                             
 [4042] "Epithelioid_Hemangioma"                                                                                                                                               
 [4043] "Verrucous_Keratotic_Hemangioma"                                                                                                                                       
 [4044] "Benign_Hemangiopericytoma"                                                                                                                                            
 [4045] "Malignant_Hemangiopericytoma"                                                                                                                                         
 [4046] "Periosteal_Chondroma"                                                                                                                                                 
 [4047] "Myxoid_Chondrosarcoma"                                                                                                                                                
 [4048] "Malignant_Giant_Cell_Tumor_of_Bone"                                                                                                                                   
 [4049] "Adamantinoma_of_Long_Bones"                                                                                                                                           
 [4050] "Benign_Odontogenic_Neoplasm"                                                                                                                                          
 [4051] "Dentinoma"                                                                                                                                                            
 [4052] "Benign_Cementoblastoma"                                                                                                                                               
 [4053] "Complex_Odontoma"                                                                                                                                                     
 [4054] "Adenomatoid_Odontogenic_Tumor"                                                                                                                                        
 [4055] "Odontogenic_Ghost_Cell_Neoplasm"                                                                                                                                      
 [4056] "Malignant_Ameloblastoma"                                                                                                                                              
 [4057] "Ameloblastoma"                                                                                                                                                        
 [4058] "Odontogenic_Fibroma"                                                                                                                                                  
 [4059] "Peripheral_Odontogenic_Fibroma"                                                                                                                                       
 [4060] "Ameloblastic_Fibroma"                                                                                                                                                 
 [4061] "Ameloblastic_Fibrosarcoma"                                                                                                                                            
 [4062] "Gliomatosis_Cerebri"                                                                                                                                                  
 [4063] "Papillary_Ependymoma"                                                                                                                                                 
 [4064] "Protoplasmic_Astrocytoma"                                                                                                                                             
 [4065] "Gemistocytic_Astrocytoma"                                                                                                                                             
 [4066] "Fibrillary_Astrocytoma"                                                                                                                                               
 [4067] "Pleomorphic_Xanthoastrocytoma"                                                                                                                                        
 [4068] "Astroblastoma"                                                                                                                                                        
 [4069] "Giant_Cell_Glioblastoma"                                                                                                                                              
 [4070] "Anaplastic_Oligodendroglioma"                                                                                                                                         
 [4071] "Medulloepithelioma"                                                                                                                                                   
 [4072] "Pacinian_Neurofibroma"                                                                                                                                                
 [4073] "Meningothelial_Meningioma"                                                                                                                                            
 [4074] "Fibrous_Meningioma"                                                                                                                                                   
 [4075] "Psammomatous_Meningioma"                                                                                                                                              
 [4076] "Angiomatous_Meningioma"                                                                                                                                               
 [4077] "Transitional_Meningioma"                                                                                                                                              
 [4078] "Meningeal_Sarcomatosis"                                                                                                                                               
 [4079] "Malignant_Triton_Tumor"                                                                                                                                               
 [4080] "Malignant_Granular_Cell_Tumor"                                                                                                                                        
 [4081] "Mantle_Cell_Lymphoma"                                                                                                                                                 
 [4082] "Diffuse_Centroblastic-Centrocytic_Lymphoma"                                                                                                                           
 [4083] "Multifocal_Lymphomatous_Polyposis"                                                                                                                                    
 [4084] "Unspecified_Peripheral_T-Cell_Lymphoma"                                                                                                                               
 [4085] "Marginal_Zone_B-Cell_Lymphoma"                                                                                                                                        
 [4086] "Intravascular_Large_B-Cell_Lymphoma"                                                                                                                                  
 [4087] "Aleukemic_Lymphoid_Leukemia"                                                                                                                                          
 [4088] "Acute_Panmyelosis_with_Myelofibrosis"                                                                                                                                 
 [4089] "Chronic_Myeloproliferative_Disorder"                                                                                                                                  
 [4090] "Sebaceous_Epithelioma"                                                                                                                                                
 [4091] "Childhood_Cerebral_Astrocytoma"                                                                                                                                       
 [4092] "Non-Functioning_Pituitary_Gland_Adenoma"                                                                                                                              
 [4093] "Colon_Adenocarcinoma"                                                                                                                                                 
 [4094] "Limbic_Encephalitis"                                                                                                                                                  
 [4095] "Choroid_Plexus_Cyst"                                                                                                                                                  
 [4096] "Ependymal_Cyst"                                                                                                                                                       
 [4097] "Benign_Eyelid_Neoplasm"                                                                                                                                               
 [4098] "Eyelid_Squamous_Cell_Papilloma"                                                                                                                                       
 [4099] "Eyelid_Seborrheic_Keratosis"                                                                                                                                          
 [4100] "Eyelid_Capillary_Hemangioma"                                                                                                                                          
 [4101] "Eyelid_Melanoma"                                                                                                                                                      
 [4102] "Lacrimal_Gland_Cyst"                                                                                                                                                  
 [4103] "Lacrimal_Gland_Neoplasm"                                                                                                                                              
 [4104] "Corneal_Neoplasm"                                                                                                                                                     
 [4105] "Iris_Miotic_Cyst"                                                                                                                                                     
 [4106] "Ciliary_Body_Miotic_Cyst"                                                                                                                                             
 [4107] "Ciliary_Body_Neoplasm"                                                                                                                                                
 [4108] "Retinal_Lymphoma"                                                                                                                                                     
 [4109] "External_Auditory_Canal_Polyp"                                                                                                                                        
 [4110] "Frontal_Sinus_Polyp"                                                                                                                                                  
 [4111] "Nasal_Cavity_Cyst"                                                                                                                                                    
 [4112] "Nasal_Vestibule_Squamous_Papilloma"                                                                                                                                   
 [4113] "Skin_Lymphangioleiomyomatosis"                                                                                                                                        
 [4114] "Pregnancy_Associated_Hypertension"                                                                                                                                    
 [4115] "Cherry_Hemangioma_of_Lip"                                                                                                                                             
 [4116] "Gastric_Hamartoma"                                                                                                                                                    
 [4117] "Pancreatic_Cystadenoma"                                                                                                                                               
 [4118] "Islet_Cell_Adenomatosis"                                                                                                                                              
 [4119] "Renal_Failure"                                                                                                                                                        
 [4120] "Adult_Fanconi_Anemia"                                                                                                                                                 
 [4121] "Paraurethral_Gland_Neoplasm"                                                                                                                                          
 [4122] "Scrotal_Sebaceous_Cyst"                                                                                                                                               
 [4123] "Scrotal_Neoplasm"                                                                                                                                                     
 [4124] "Ovarian_Epithelial_Neoplasm"                                                                                                                                          
 [4125] "Vulvar_Condyloma_Acuminatum"                                                                                                                                          
 [4126] "Erosive_Nipple_Adenomatosis"                                                                                                                                          
 [4127] "Parathyroid_Cyst"                                                                                                                                                     
 [4128] "Hypothalamic_Hamartoma"                                                                                                                                               
 [4129] "Adrenal_Cyst"                                                                                                                                                         
 [4130] "Ectopic_ACTH_Syndrome"                                                                                                                                                
 [4131] "Thiopurine_Methyltransferase_Deficiency"                                                                                                                              
 [4132] "Cherry_Hemangioma"                                                                                                                                                    
 [4133] "Papillary_Endothelial_Hyperplasia"                                                                                                                                    
 [4134] "Cervical_Symmetrical_Lipomatosis"                                                                                                                                     
 [4135] "Senile_Nevus"                                                                                                                                                         
 [4136] "Anogenital_Papillomaviral_Intraepithelial_Neoplasia"                                                                                                                  
 [4137] "Hepatic_Schistosomal_Granuloma"                                                                                                                                       
 [4138] "Malignant_Adrenal_Medulla_Neoplasm"                                                                                                                                   
 [4139] "Carcinoma_Ex_Pleomorphic_Adenoma"                                                                                                                                     
 [4140] "Spinal_Arachnoid_Cyst"                                                                                                                                                
 [4141] "Salmon_Patch_Nevus"                                                                                                                                                   
 [4142] "Posterior_Tongue_Neoplasm"                                                                                                                                            
 [4143] "Floor_of_the_Mouth_Neoplasm"                                                                                                                                          
 [4144] "Palate_Neoplasm"                                                                                                                                                      
 [4145] "Benign_Hard_Palate_Neoplasm"                                                                                                                                          
 [4146] "Benign_Soft_Palate_Neoplasm"                                                                                                                                          
 [4147] "Buccal_Mucosa_Neoplasm"                                                                                                                                               
 [4148] "Benign_Buccal_Mucosa_Neoplasm"                                                                                                                                        
 [4149] "Major_Salivary_Gland_Neoplasm"                                                                                                                                        
 [4150] "Benign_Posterior_Tongue_Neoplasm"                                                                                                                                     
 [4151] "Minor_Salivary_Gland_Neoplasm"                                                                                                                                        
 [4152] "Malignant_Minor_Salivary_Gland_Neoplasm"                                                                                                                              
 [4153] "Benign_Minor_Salivary_Gland_Neoplasm"                                                                                                                                 
 [4154] "Middle_Ear_Neoplasm"                                                                                                                                                  
 [4155] "Nasal_Cavity_Neoplasm"                                                                                                                                                
 [4156] "Benign_Maxillary_Sinus_Neoplasm"                                                                                                                                      
 [4157] "Ethmoid_Sinus_Neoplasm"                                                                                                                                               
 [4158] "Benign_Ethmoid_Sinus_Neoplasm"                                                                                                                                        
 [4159] "Frontal_Sinus_Neoplasm"                                                                                                                                               
 [4160] "Benign_Frontal_Sinus_Neoplasm"                                                                                                                                        
 [4161] "Benign_Sphenoid_Sinus_Neoplasm"                                                                                                                                       
 [4162] "Pyriform_Fossa_Neoplasm"                                                                                                                                              
 [4163] "Glottis_Neoplasm"                                                                                                                                                     
 [4164] "Subglottis_Neoplasm"                                                                                                                                                  
 [4165] "Benign_Subglottis_Neoplasm"                                                                                                                                           
 [4166] "Gastric_Cardia_Carcinoma_in_situ"                                                                                                                                     
 [4167] "Gastric_Fundus_Carcinoma_in_situ"                                                                                                                                     
 [4168] "Gastric_Body_Carcinoma_in_situ"                                                                                                                                       
 [4169] "Gastric_Pylorus_Carcinoma_in_situ"                                                                                                                                    
 [4170] "Small_Intestinal_Neoplasm"                                                                                                                                            
 [4171] "Cecum_Neoplasm"                                                                                                                                                       
 [4172] "Appendix_Neoplasm"                                                                                                                                                    
 [4173] "Anal_Fibrous_Polyp"                                                                                                                                                   
 [4174] "Cholangiocarcinoma"                                                                                                                                                   
 [4175] "Hepatic_Sarcoma"                                                                                                                                                      
 [4176] "Hepatic_Angiosarcoma"                                                                                                                                                 
 [4177] "Stage_0_Gallbladder_Cancer"                                                                                                                                           
 [4178] "Benign_Gallbladder_Neoplasm"                                                                                                                                          
 [4179] "Extrahepatic_Bile_Duct_Neoplasm"                                                                                                                                      
 [4180] "Stage_0_Extrahepatic_Bile_Duct_Cancer"                                                                                                                                
 [4181] "Ampulla_of_Vater_Neoplasm"                                                                                                                                            
 [4182] "Stage_0_Ampulla_of_Vater_Cancer"                                                                                                                                      
 [4183] "Exocrine_Pancreas_Neoplasm"                                                                                                                                           
 [4184] "Pancreatic_Carcinoid_Tumor"                                                                                                                                           
 [4185] "Benign_Retroperitoneal_Neoplasm"                                                                                                                                      
 [4186] "Tracheal_Squamous_Cell_Carcinoma"                                                                                                                                     
 [4187] "Large_Cell_Lung_Carcinoma"                                                                                                                                            
 [4188] "Clear_Cell_Lung_Carcinoma"                                                                                                                                            
 [4189] "Giant_Cell_Lung_Carcinoma"                                                                                                                                            
 [4190] "Lung_Epithelioid_Hemangioendothelioma"                                                                                                                                
 [4191] "Benign_Lung_Neoplasm"                                                                                                                                                 
 [4192] "Lung_Adenoma"                                                                                                                                                         
 [4193] "Malignant_Mesothelioma"                                                                                                                                               
 [4194] "Pleural_Fibroma"                                                                                                                                                      
 [4195] "Benign_Thymus_Neoplasm"                                                                                                                                               
 [4196] "Clear_Cell_Squamous_Cell_Skin_Carcinoma"                                                                                                                              
 [4197] "Acantholytic_Squamous_Cell_Skin_Carcinoma"                                                                                                                            
 [4198] "Multiple_Self_Healing_Epithelioma_of_Ferguson-Smith"                                                                                                                  
 [4199] "Squamous_Cell_Skin_Papilloma"                                                                                                                                         
 [4200] "Skin_Appendage_Neoplasm"                                                                                                                                              
 [4201] "Vellus_Hair_Cyst"                                                                                                                                                     
 [4202] "Pilar_Sheath_Acanthoma"                                                                                                                                               
 [4203] "Follicular_Infundibulum_Neoplasm"                                                                                                                                     
 [4204] "Perifollicular_Fibroma"                                                                                                                                               
 [4205] "Adenoid_Cystic_Skin_Carcinoma"                                                                                                                                        
 [4206] "Mucoepidermoid_Skin_Carcinoma"                                                                                                                                        
 [4207] "Eccrine_Dermal_Duct_Neoplasm"                                                                                                                                         
 [4208] "Benign_Mixed_Tumor_of_the_Skin_Chondroid_Syringoma"                                                                                                                   
 [4209] "Dermal_Neoplasm"                                                                                                                                                      
 [4210] "Skin_Verruciform_Xanthoma"                                                                                                                                            
 [4211] "Cutaneous_Neural_Neoplasm"                                                                                                                                            
 [4212] "Cutaneous_Smooth_Muscle_Neoplasm"                                                                                                                                     
 [4213] "Cutaneous_Ganglioneuroma"                                                                                                                                             
 [4214] "Cutaneous_Leiomyoma"                                                                                                                                                  
 [4215] "Dartoic_Leiomyoma"                                                                                                                                                    
 [4216] "Cutaneous_Leiomyosarcoma"                                                                                                                                             
 [4217] "Cobb_s_Syndrome"                                                                                                                                                      
 [4218] "Blue_Rubber_Bleb_Nevus"                                                                                                                                               
 [4219] "Tufted_Hemangioma"                                                                                                                                                    
 [4220] "Skin_Angiokeratoma"                                                                                                                                                   
 [4221] "Skin_Angiosarcoma"                                                                                                                                                    
 [4222] "Skin_Lymphangiosarcoma"                                                                                                                                               
 [4223] "Glomus_Tumor_of_the_Skin"                                                                                                                                             
 [4224] "Skin_Hemangiopericytoma"                                                                                                                                              
 [4225] "Malignant_Skin_Hemangiopericytoma"                                                                                                                                    
 [4226] "Skin_Hemangioendothelioma"                                                                                                                                            
 [4227] "Cockade_Nevus"                                                                                                                                                        
 [4228] "Common_Blue_Nevus"                                                                                                                                                    
 [4229] "Desmoplastic_Nevus"                                                                                                                                                   
 [4230] "Nevus_Spilus"                                                                                                                                                         
 [4231] "Benign_Pleural_Mesothelioma"                                                                                                                                          
 [4232] "Benign_Pericardial_Mesothelioma"                                                                                                                                      
 [4233] "Malignant_Lipomatous_Neoplasm"                                                                                                                                        
 [4234] "Benign_Lipomatous_Neoplasm"                                                                                                                                           
 [4235] "Hereditary_Breast_Carcinoma"                                                                                                                                          
 [4236] "Malignant_Phyllodes_Breast_Tumor"                                                                                                                                     
 [4237] "Benign_Breast_Neoplasm"                                                                                                                                               
 [4238] "Ovarian_Papillary_Cystadenocarcinoma"                                                                                                                                 
 [4239] "Ovarian_Mixed_Epithelial_Neoplasm"                                                                                                                                    
 [4240] "Undifferentiated_Ovarian_Carcinoma"                                                                                                                                   
 [4241] "Benign_Ovarian_Epithelial_Neoplasm"                                                                                                                                   
 [4242] "Ovarian_Serous_Cystadenoma"                                                                                                                                           
 [4243] "Ovarian_Mucinous_Cystadenoma"                                                                                                                                         
 [4244] "Ovarian_Gynandroblastoma"                                                                                                                                             
 [4245] "Malignant_Ovarian_Germ_Cell_Tumor"                                                                                                                                    
 [4246] "Ovarian_Choriocarcinoma"                                                                                                                                              
 [4247] "Benign_Ovarian_Germ_Cell_Neoplasm"                                                                                                                                    
 [4248] "Benign_Fallopian_Tube_Neoplasm"                                                                                                                                       
 [4249] "Intravenous_Leiomyomatosis"                                                                                                                                           
 [4250] "Cervical_Adenosquamous_Carcinoma"                                                                                                                                     
 [4251] "Cervical_Adenocarcinoma_in_situ"                                                                                                                                      
 [4252] "Vaginal_Intraepithelial_Neoplasia"                                                                                                                                    
 [4253] "Stage_0_Vulvar_Cancer"                                                                                                                                                
 [4254] "Stage_0_Testicular_Cancer"                                                                                                                                            
 [4255] "Multilocular_Cystic_Renal_Cell_Carcinoma"                                                                                                                             
 [4256] "Renal_Sarcoma"                                                                                                                                                        
 [4257] "Renal_Oncocytoma"                                                                                                                                                     
 [4258] "Kidney_Hemangiopericytoma"                                                                                                                                            
 [4259] "Renal_Pelvis_Papilloma"                                                                                                                                               
 [4260] "Stage_0is_Ureter_Cancer"                                                                                                                                              
 [4261] "Ureter_Polyp"                                                                                                                                                         
 [4262] "Stage_0is_Urethral_Cancer"                                                                                                                                            
 [4263] "Benign_Paraurethral_Gland_Neoplasm"                                                                                                                                   
 [4264] "Malignant_Choroid_Plexus_Neoplasm"                                                                                                                                    
 [4265] "Spinal_Cord_Glial_Neoplasm"                                                                                                                                           
 [4266] "Spinal_Cord_Oligodendroglioma"                                                                                                                                        
 [4267] "Pituitary_Gland_Carcinoma"                                                                                                                                            
 [4268] "Optic_Nerve_Glioma"                                                                                                                                                   
 [4269] "Optic_Nerve_Sheath_Meningioma"                                                                                                                                        
 [4270] "Malignant_Vestibulocochlear_Nerve_Neoplasm"                                                                                                                           
 [4271] "Lacrimal_Gland_Adenoid_Cystic_Carcinoma"                                                                                                                              
 [4272] "Lacrimal_Gland_Adenocarcinoma"                                                                                                                                        
 [4273] "Lacrimal_Gland_Pleomorphic_Adenoma"                                                                                                                                   
 [4274] "Orbit_Rhabdomyosarcoma"                                                                                                                                               
 [4275] "Malignant_Orbit_Hemangiopericytoma"                                                                                                                                   
 [4276] "Orbit_Capillary_Hemangioma"                                                                                                                                           
 [4277] "Orbit_Cavernous_Hemangioma"                                                                                                                                           
 [4278] "Orbit_Hemangiopericytoma"                                                                                                                                             
 [4279] "Orbit_Dermoid_Cyst"                                                                                                                                                   
 [4280] "Conjunctival_Squamous_Cell_Carcinoma"                                                                                                                                 
 [4281] "Conjunctival_Melanoma"                                                                                                                                                
 [4282] "Conjunctival_Nevus"                                                                                                                                                   
 [4283] "Corneal_Squamous_Cell_Carcinoma"                                                                                                                                      
 [4284] "Corneal_Melanoma"                                                                                                                                                     
 [4285] "Malignant_Iris_Neoplasm"                                                                                                                                              
 [4286] "Benign_Iris_Neoplasm"                                                                                                                                                 
 [4287] "Iris_Nevus"                                                                                                                                                           
 [4288] "Ciliary_Body_Medulloepithelioma"                                                                                                                                      
 [4289] "Ciliary_Body_Melanoma"                                                                                                                                                
 [4290] "Ciliary_Body_Fuchs_Adenoma"                                                                                                                                           
 [4291] "Ciliary_Body_Leiomyoma"                                                                                                                                               
 [4292] "Choroid_Melanoma"                                                                                                                                                     
 [4293] "Choroid_Hemangioma"                                                                                                                                                   
 [4294] "Chronic_Eosinophilic_Leukemia"                                                                                                                                        
 [4295] "Splenic_Angiosarcoma"                                                                                                                                                 
 [4296] "Benign_Thoracic_Neoplasm"                                                                                                                                             
 [4297] "Malignant_Lung_Hilum_Neoplasm"                                                                                                                                        
 [4298] "Malignant_Pericardial_Neoplasm"                                                                                                                                       
 [4299] "Malignant_Epicardial_Neoplasm"                                                                                                                                        
 [4300] "Malignant_Myocardial_Neoplasm"                                                                                                                                        
 [4301] "Malignant_Endocardial_Neoplasm"                                                                                                                                       
 [4302] "Malignant_Respiratory_Tract_Neoplasm"                                                                                                                                 
 [4303] "Malignant_Intestinal_Neoplasm"                                                                                                                                        
 [4304] "Malignant_Skin_Appendage_Neoplasm"                                                                                                                                    
 [4305] "Malignant_Dermal_Neoplasm"                                                                                                                                            
 [4306] "Malignant_Great_Vessel_Neoplasm"                                                                                                                                      
 [4307] "Malignant_Thalamic_Neoplasm"                                                                                                                                          
 [4308] "Malignant_Cerebral_Neoplasm"                                                                                                                                          
 [4309] "Conjunctival_Kaposi_s_Sarcoma"                                                                                                                                        
 [4310] "Corneal_Kaposi_s_Sarcoma"                                                                                                                                             
 [4311] "Malignant_Chest_Wall_Neoplasm"                                                                                                                                        
 [4312] "Metastatic_Neoplasm_to_the_Large_Intestine"                                                                                                                           
 [4313] "Metastatic_Neoplasm_to_the_Bone_Marrow"                                                                                                                               
 [4314] "Metastatic_Neoplasm_to_the_Peritoneum"                                                                                                                                
 [4315] "Metastatic_Neoplasm_to_the_Testis"                                                                                                                                    
 [4316] "Metastasis_to_Spinal_Cord"                                                                                                                                            
 [4317] "Metastatic_Neoplasm_to_the_Eye"                                                                                                                                       
 [4318] "Stage_0_Oral_Cavity_Carcinoma"                                                                                                                                        
 [4319] "Stage_0_Lip_Cancer"                                                                                                                                                   
 [4320] "Stage_0_Nasal_Cavity_Carcinoma"                                                                                                                                       
 [4321] "Stage_0_Oropharyngeal_Carcinoma"                                                                                                                                      
 [4322] "Carcinoma_in_situ_of_the_Hypopharynx"                                                                                                                                 
 [4323] "Stage_0_Epiglottic_Carcinoma"                                                                                                                                         
 [4324] "Stage_0_Appendix_Carcinoma"                                                                                                                                           
 [4325] "Cecum_Carcinoma_in_situ"                                                                                                                                              
 [4326] "Anal_Intraepithelial_Neoplasia"                                                                                                                                       
 [4327] "Penile_Intraepithelial_Neoplasia"                                                                                                                                     
 [4328] "Stage_0is_Renal_Pelvis_Carcinoma"                                                                                                                                     
 [4329] "Benign_Gingival_Neoplasm"                                                                                                                                             
 [4330] "Benign_Palate_Neoplasm"                                                                                                                                               
 [4331] "Benign_Salivary_Gland_Neoplasm"                                                                                                                                       
 [4332] "Benign_Sublingual_Gland_Neoplasm"                                                                                                                                     
 [4333] "Benign_Middle_Ear_Neoplasm"                                                                                                                                           
 [4334] "Benign_Nasal_Cavity_Neoplasm"                                                                                                                                         
 [4335] "Benign_Oropharyngeal_Neoplasm"                                                                                                                                        
 [4336] "Benign_Glottis_Neoplasm"                                                                                                                                              
 [4337] "Benign_Epiglottis_Neoplasm"                                                                                                                                           
 [4338] "Benign_Myocardial_Neoplasm"                                                                                                                                           
 [4339] "Benign_Endocardial_Neoplasm"                                                                                                                                          
 [4340] "Benign_Intestinal_Neoplasm"                                                                                                                                           
 [4341] "Benign_Colorectal_Neoplasm"                                                                                                                                           
 [4342] "Benign_Anal_Neoplasm"                                                                                                                                                 
 [4343] "Benign_Pancreatic_Neoplasm"                                                                                                                                           
 [4344] "Benign_Exocrine_Pancreatic_Neoplasm"                                                                                                                                  
 [4345] "Skin_Papilloma"                                                                                                                                                       
 [4346] "Benign_Skin_Appendage_Neoplasm"                                                                                                                                       
 [4347] "Cutaneous_Lipoma"                                                                                                                                                     
 [4348] "External_Ear_Lipoma"                                                                                                                                                  
 [4349] "Spinal_Cord_Lipoma"                                                                                                                                                   
 [4350] "Benign_Male_Breast_Neoplasm"                                                                                                                                          
 [4351] "Benign_Endocrine_Neoplasm"                                                                                                                                            
 [4352] "Meningeal_Cyst"                                                                                                                                                       
 [4353] "Malignant_Jugulotympanic_Paraganglioma"                                                                                                                               
 [4354] "Malignant_Coccygeal_Body_Neoplasm"                                                                                                                                    
 [4355] "Malignant_Central_Nervous_System_Neoplasm"                                                                                                                            
 [4356] "Malignant_Neoplasms_of_the_Meninges"                                                                                                                                  
 [4357] "Low-Grade_Cervical_Intraepithelial_Neoplasia"                                                                                                                         
 [4358] "Grade_II_Cervical_Intraepithelial_Neoplasia"                                                                                                                          
 [4359] "Dermoid_Cyst_of_the_Skin"                                                                                                                                             
 [4360] "Amelanotic_Skin_Melanoma"                                                                                                                                             
 [4361] "Cutaneous_Fibrous_Tissue_Neoplasm"                                                                                                                                    
 [4362] "Gastric_Carcinoid_Tumor"                                                                                                                                              
 [4363] "Gastric_Lymphoma"                                                                                                                                                     
 [4364] "Intestinal_Carcinoid_Tumor"                                                                                                                                           
 [4365] "Small_Intestinal_Carcinoid_Tumor"                                                                                                                                     
 [4366] "Anal_Melanoma"                                                                                                                                                        
 [4367] "Rectal_Melanoma"                                                                                                                                                      
 [4368] "Spinal_Cord_Astrocytoma"                                                                                                                                              
 [4369] "Brain_Glioblastoma"                                                                                                                                                   
 [4370] "Scrotal_Squamous_Cell_Carcinoma"                                                                                                                                      
 [4371] "Low_Grade_Vaginal_Intraepithelial_Neoplasia"                                                                                                                          
 [4372] "Grade_II_Vaginal_Intraepithelial_Neoplasia"                                                                                                                           
 [4373] "Gestational_Choriocarcinoma"                                                                                                                                          
 [4374] "Breast_Lipoma"                                                                                                                                                        
 [4375] "Tongue_Squamous_Cell_Carcinoma"                                                                                                                                       
 [4376] "Palate_Squamous_Cell_Carcinoma"                                                                                                                                       
 [4377] "Parotid_Gland_Pleomorphic_Adenoma"                                                                                                                                    
 [4378] "Pericardial_Neoplasm"                                                                                                                                                 
 [4379] "External_Ear_Neoplasm"                                                                                                                                                
 [4380] "Malignant_External_Ear_Neoplasm"                                                                                                                                      
 [4381] "Atypical_Endometrial_Hyperplasia"                                                                                                                                     
 [4382] "Trigeminal_Schwannoma"                                                                                                                                                
 [4383] "Intracranial_Meningioma"                                                                                                                                              
 [4384] "Central_Nervous_System_Cyst"                                                                                                                                          
 [4385] "Epidermoid_Intraspinal_Cyst"                                                                                                                                          
 [4386] "Pineal_Region_Germ_Cell_Tumor"                                                                                                                                        
 [4387] "Meningeal_Hemangiopericytoma"                                                                                                                                         
 [4388] "Primary_Melanocytic_Lesion_of_Meninges"                                                                                                                               
 [4389] "Meningeal_Melanocytoma"                                                                                                                                               
 [4390] "Splenic_Marginal_Zone_Lymphoma"                                                                                                                                       
 [4391] "T-Cell_Large_Granular_Lymphocyte_Leukemia"                                                                                                                            
 [4392] "Plasma_Cell_Neoplasm"                                                                                                                                                 
 [4393] "Spindle_Cell_Sarcomatoid_Squamous_Cell_Skin_Carcinoma"                                                                                                                
 [4394] "Immature_Mediastinal_Teratoma"                                                                                                                                        
 [4395] "Bladder_Sarcoma"                                                                                                                                                      
 [4396] "Breast_Sarcoma"                                                                                                                                                       
 [4397] "Breast_Lymphoma"                                                                                                                                                      
 [4398] "Testicular_Sertoli_Cell_Tumor"                                                                                                                                        
 [4399] "Acute_Biphenotypic_Leukemia"                                                                                                                                          
 [4400] "Verrucous_Nevus"                                                                                                                                                      
 [4401] "Congenital_Epulis"                                                                                                                                                    
 [4402] "Skull_Base_Neoplasm"                                                                                                                                                  
 [4403] "Organoid_Nevus"                                                                                                                                                       
 [4404] "Laryngeal_Keratosis"                                                                                                                                                  
 [4405] "Plantar_Fibromatosis"                                                                                                                                                 
 [4406] "Hypomelia_Hypotrichosis_Facial_Hemangioma_Syndrome"                                                                                                                   
 [4407] "X-Linked_Severe_Combined_Immunodeficiency"                                                                                                                            
 [4408] "Dermatofibrosarcoma_Protuberans"                                                                                                                                      
 [4409] "Nasal_Type_Extranodal_NK_T-Cell_Lymphoma"                                                                                                                             
 [4410] "Paraneoplastic_Cerebellar_Degeneration"                                                                                                                               
 [4411] "Opsoclonus_Myoclonus_Syndrome"                                                                                                                                        
 [4412] "Tactile_Epilepsy"                                                                                                                                                     
 [4413] "Paget_s_Disease_of_the_Skin"                                                                                                                                          
 [4414] "Leukocyte_Adhesion_Deficiency_Type_1"                                                                                                                                 
 [4415] "Leukocyte_Adhesion_Deficiency_Type_2"                                                                                                                                 
 [4416] "Complement_Deficiency"                                                                                                                                                
 [4417] "Nijmegen_Breakage_Syndrome"                                                                                                                                           
 [4418] "Gingival_Fibroepithelial_Polyp"                                                                                                                                       
 [4419] "Ulcerated_Oral_Leukoplakia"                                                                                                                                           
 [4420] "Speckled_Oral_Leukoplakia"                                                                                                                                            
 [4421] "Verrucous_Oral_Leukoplakia"                                                                                                                                           
 [4422] "Smokers_Keratosis"                                                                                                                                                    
 [4423] "Dry_Orgasm"                                                                                                                                                           
 [4424] "Gestational_Trophoblastic_Tumor"                                                                                                                                      
 [4425] "Giant_Cell_Fibroblastoma"                                                                                                                                             
 [4426] "Encephalocraniocutaneous_Lipomatosis"                                                                                                                                 
 [4427] "Palmoplantar_Keratoderma_with_Leukoplakia"                                                                                                                            
 [4428] "Eccrine_Angiomatous_Hamartoma"                                                                                                                                        
 [4429] "Moniliform_Hamartoma"                                                                                                                                                 
 [4430] "Carney_Complex"                                                                                                                                                       
 [4431] "Circumscribed_Storiform_Collagenoma"                                                                                                                                  
 [4432] "Eruptive_Collagenoma"                                                                                                                                                 
 [4433] "Limbal_Metaplasia"                                                                                                                                                    
 [4434] "Interaretynoid_Leukoplakia"                                                                                                                                           
 [4435] "Left_Ventricular_Ejection_Fraction"                                                                                                                                   
 [4436] "Borderline_Cystadenoma"                                                                                                                                               
 [4437] "Adenocarcinoma_with_Metaplasia"                                                                                                                                       
 [4438] "Cellular_Ependymoma"                                                                                                                                                  
 [4439] "Clear_Cell_Ependymoma"                                                                                                                                                
 [4440] "Choroid_Plexus_Carcinoma"                                                                                                                                             
 [4441] "Rhabdomyosarcoma_with_Ganglionic_Differentiation"                                                                                                                     
 [4442] "Anaplastic_Ganglioglioma"                                                                                                                                             
 [4443] "Secretory_Meningioma"                                                                                                                                                 
 [4444] "Choroid_Plexus_Meningioma"                                                                                                                                            
 [4445] "Lymphoplasmacyte-Rich_Meningioma"                                                                                                                                     
 [4446] "Microcystic_Meningioma"                                                                                                                                               
 [4447] "Clear_Cell_Meningioma"                                                                                                                                                
 [4448] "Atypical_Meningioma"                                                                                                                                                  
 [4449] "Cellular_Schwannoma"                                                                                                                                                  
 [4450] "Papillary_Craniopharyngioma"                                                                                                                                          
 [4451] "Adamantinous_Craniopharyngioma"                                                                                                                                       
 [4452] "Post-Transplant_Lymphoproliferative_Disorder"                                                                                                                         
 [4453] "Proliferative_Fasciitis"                                                                                                                                              
 [4454] "Intravascular_Nodular_Fasciitis"                                                                                                                                      
 [4455] "Atypical_Lobular_Breast_Hyperplasia"                                                                                                                                  
 [4456] "Neuropathy"                                                                                                                                                           
 [4457] "Neonatal_Hypertension"                                                                                                                                                
 [4458] "Peutz-Jeghers_Polyp"                                                                                                                                                  
 [4459] "Non-Secretory_Myeloma"                                                                                                                                                
 [4460] "Low-Grade_T-Cell_Lymphoma"                                                                                                                                            
 [4461] "High-Grade_T-Cell_Lymphoma"                                                                                                                                           
 [4462] "Enteropathy-Type_T-Cell_Lymphoma"                                                                                                                                     
 [4463] "Desmoplastic_Infantile_Ganglioglioma"                                                                                                                                 
 [4464] "Acrosyringeal_Nevus"                                                                                                                                                  
 [4465] "Porokeratotic_Eccrine_Ostial_and_Dermal_Duct_Nevus"                                                                                                                   
 [4466] "Neoplasm_by_Morphology"                                                                                                                                               
 [4467] "Benign_Squamous_Cell_Neoplasm"                                                                                                                                        
 [4468] "Benign_Basal_Cell_Neoplasm"                                                                                                                                           
 [4469] "Coccygeal_Body_Neoplasm"                                                                                                                                              
 [4470] "Benign_Brenner_Tumor"                                                                                                                                                 
 [4471] "Neuronal_and_Mixed_Neuronal-Glial_Tumor"                                                                                                                              
 [4472] "Malignant_Melanocytic_Peripheral_Nerve_Sheath_Tumor"                                                                                                                  
 [4473] "Basal_Cell_Nevus_with_Comedones"                                                                                                                                      
 [4474] "Skin_Unilateral_Segmental_Cavernous_Hemangioma"                                                                                                                       
 [4475] "Pigmented_Spindle_Cell_Nevus"                                                                                                                                         
 [4476] "T-Cell_Prolymphocytic_Leukemia"                                                                                                                                       
 [4477] "B-Cell_Prolymphocytic_Leukemia"                                                                                                                                       
 [4478] "Spindle_Cell_Hemangioma"                                                                                                                                              
 [4479] "Chondrogenic_Neoplasm"                                                                                                                                                
 [4480] "Vulvar_Intraepithelial_Neoplasia"                                                                                                                                     
 [4481] "Hypertensive_Nephropathy"                                                                                                                                             
 [4482] "Metastatic_Neoplasm_to_the_Liver"                                                                                                                                     
 [4483] "Oral_Cavity_Cyst"                                                                                                                                                     
 [4484] "Low_Grade_Vulvar_Intraepithelial_Neoplasia"                                                                                                                           
 [4485] "Grade_II_Vulvar_Intraepithelial_Neoplasia"                                                                                                                            
 [4486] "Malignant_Major_Salivary_Gland_Neoplasm"                                                                                                                              
 [4487] "Malignant_Neoplasm_of_the_Cervical_Esophagus"                                                                                                                         
 [4488] "Malignant_Neoplasm_of_the_Abdominal_Esophagus"                                                                                                                        
 [4489] "Malignant_Middle_Ear_Neoplasm"                                                                                                                                        
 [4490] "Malignant_Ciliary_Body_Neoplasm"                                                                                                                                      
 [4491] "Malignant_Eye_Neoplasm"                                                                                                                                               
 [4492] "Malignant_Olfactory_Nerve_Neoplasm"                                                                                                                                   
 [4493] "Malignant_Pituitary_Gland_Neoplasm"                                                                                                                                   
 [4494] "Benign_Parotid_Gland_Neoplasm"                                                                                                                                        
 [4495] "Benign_Major_Salivary_Gland_Neoplasm"                                                                                                                                 
 [4496] "Benign_Cecum_Neoplasm"                                                                                                                                                
 [4497] "Benign_Appendix_Neoplasm"                                                                                                                                             
 [4498] "Benign_Rectal_Neoplasm"                                                                                                                                               
 [4499] "Benign_Duodenal_Neoplasm"                                                                                                                                             
 [4500] "Benign_Extrahepatic_Bile_Duct_Neoplasm"                                                                                                                               
 [4501] "Benign_Male_Reproductive_System_Neoplasm"                                                                                                                             
 [4502] "Benign_Renal_Neoplasm"                                                                                                                                                
 [4503] "Benign_Ciliary_Body_Neoplasm"                                                                                                                                         
 [4504] "Benign_Eye_Neoplasm"                                                                                                                                                  
 [4505] "Benign_Brain_Neoplasm"                                                                                                                                                
 [4506] "Benign_Pituitary_Gland_Neoplasm"                                                                                                                                      
 [4507] "Borderline_Ovarian_Epithelial_Neoplasm"                                                                                                                               
 [4508] "Cardiovascular_Neoplasm"                                                                                                                                              
 [4509] "Uncomplicated_Hypertension"                                                                                                                                           
 [4510] "Dementia"                                                                                                                                                             
 [4511] "Benign_Gastrointestinal_Neoplasm"                                                                                                                                     
 [4512] "Malignant_Nervous_System_Neoplasm"                                                                                                                                    
 [4513] "Benign_Nervous_System_Neoplasm"                                                                                                                                       
 [4514] "Left_Atrial_Myxoma"                                                                                                                                                   
 [4515] "Right_Atrial_Myxoma"                                                                                                                                                  
 [4516] "Colon_Lymphoma"                                                                                                                                                       
 [4517] "Lung_Lymphoma"                                                                                                                                                        
 [4518] "Prostate_Adenoma"                                                                                                                                                     
 [4519] "Hypertensive_Episode"                                                                                                                                                 
 [4520] "Perineural_Cyst"                                                                                                                                                      
 [4521] "Recurrent_Neoplasm"                                                                                                                                                   
 [4522] "Deficiency_of_Humoral_Immunity"                                                                                                                                       
 [4523] "Retinal_Neoplasm"                                                                                                                                                     
 [4524] "Optic_Nerve_Neoplasm"                                                                                                                                                 
 [4525] "Neurodegenerative_Disorder"                                                                                                                                           
 [4526] "Duodenal_Carcinoma"                                                                                                                                                   
 [4527] "Breast_Hyperplasia"                                                                                                                                                   
 [4528] "Acquired_Spider_Nevus"                                                                                                                                                
 [4529] "Congenital_Spider_Nevus"                                                                                                                                              
 [4530] "Cerebral_Meningioma"                                                                                                                                                  
 [4531] "Late_Effects"                                                                                                                                                         
 [4532] "Residual_Disease"                                                                                                                                                     
 [4533] "Malignant_Sweat_Gland_Neoplasm"                                                                                                                                       
 [4534] "Fibromatosis_Colli"                                                                                                                                                   
 [4535] "Malignant_Odontogenic_Neoplasm"                                                                                                                                       
 [4536] "Recurrent_Malignant_Neoplasm"                                                                                                                                         
 [4537] "Thyroid_Carcinoma"                                                                                                                                                    
 [4538] "Photosensitive_Dermatitis"                                                                                                                                            
 [4539] "Ewing_s_Sarcoma"                                                                                                                                                      
 [4540] "Calcifying_Aponeurotic_Fibroma"                                                                                                                                       
 [4541] "Skin_Squamous_Cell_Carcinoma"                                                                                                                                         
 [4542] "Anogenital_Human_Papilloma_Virus_Infection"                                                                                                                           
 [4543] "Malignant_Glioma"                                                                                                                                                     
 [4544] "Central_Neurocytoma"                                                                                                                                                  
 [4545] "Tongue_Carcinoma"                                                                                                                                                     
 [4546] "Tonsillar_Carcinoma"                                                                                                                                                  
 [4547] "Cerebral_Neuroblastoma"                                                                                                                                               
 [4548] "Adrenal_Neuroblastoma"                                                                                                                                                
 [4549] "Primary_Sclerosing_Cholangitis"                                                                                                                                       
 [4550] "Disseminated_Squamous_Cell_Carcinoma"                                                                                                                                 
 [4551] "Ureter_Transitional_Cell_Carcinoma"                                                                                                                                   
 [4552] "Gingival_Hemangioma"                                                                                                                                                  
 [4553] "Retroperitoneal_Sarcoma"                                                                                                                                              
 [4554] "Oral_Cavity_Squamous_Cell_Carcinoma"                                                                                                                                  
 [4555] "Primary_Bone_Osteosarcoma"                                                                                                                                            
 [4556] "Ewing_s_Sarcoma_of_Bone"                                                                                                                                              
 [4557] "Malignant_Epiglottis_Neoplasm"                                                                                                                                        
 [4558] "Dysplasia_of_Vocal_Cord"                                                                                                                                              
 [4559] "Dysplasia_of_Larynx"                                                                                                                                                  
 [4560] "Esophageal_Intraepithelial_Neoplasia"                                                                                                                                 
 [4561] "Esophageal_Low-Grade_Intraepithelial_Neoplasia"                                                                                                                       
 [4562] "Moderate_Esophageal_Dysplasia"                                                                                                                                        
 [4563] "Biliary_Tract_Intraepithelial_Neoplasia"                                                                                                                              
 [4564] "Mild_Biliary_Tract_Dysplasia"                                                                                                                                         
 [4565] "Pancreatic_Intraepithelial_Neoplasia"                                                                                                                                 
 [4566] "Grade_II_Pancreatic_Intraepithelial_Neoplasia"                                                                                                                        
 [4567] "Colon_Dysplasia"                                                                                                                                                      
 [4568] "Mild_Colon_Dysplasia"                                                                                                                                                 
 [4569] "Moderate_Colon_Dysplasia"                                                                                                                                             
 [4570] "Rectal_Dysplasia"                                                                                                                                                     
 [4571] "Mild_Rectal_Dysplasia"                                                                                                                                                
 [4572] "Moderate_Rectal_Dysplasia"                                                                                                                                            
 [4573] "Stage_0_Rectal_Cancer"                                                                                                                                                
 [4574] "Abnormal_Urine_Cytology"                                                                                                                                              
 [4575] "Laryngeal_Carcinoma"                                                                                                                                                  
 [4576] "Adrenal_Medulla_Neoplasm"                                                                                                                                             
 [4577] "Placental_Neoplasm"                                                                                                                                                   
 [4578] "Hybrid_Resistance"                                                                                                                                                    
 [4579] "Lung_Sarcoma"                                                                                                                                                         
 [4580] "Monocytic_Leukemia"                                                                                                                                                   
 [4581] "Ovarian_Sex_Cord-Stromal_Tumor"                                                                                                                                       
 [4582] "Prostate_Carcinoma"                                                                                                                                                   
 [4583] "Dental_Granuloma"                                                                                                                                                     
 [4584] "Vulvar_Carcinoma"                                                                                                                                                     
 [4585] "Malignant_Soft_Tissue_Neoplasm"                                                                                                                                       
 [4586] "Placental_Hemangioma"                                                                                                                                                 
 [4587] "Brain_Stem_Neoplasm"                                                                                                                                                  
 [4588] "Complete_Remission"                                                                                                                                                   
 [4589] "Complete_Hydatidiform_Mole"                                                                                                                                           
 [4590] "Breast_Carcinoma"                                                                                                                                                     
 [4591] "Rare_Disorder"                                                                                                                                                        
 [4592] "Cerebral_Neoplasm"                                                                                                                                                    
 [4593] "Reproductive_System_Disorder"                                                                                                                                         
 [4594] "Symptom"                                                                                                                                                              
 [4595] "Rectosigmoid_Neoplasm"                                                                                                                                                
 [4596] "Lung_Carcinoma"                                                                                                                                                       
 [4597] "Benign_Sweat_Gland_Neoplasm"                                                                                                                                          
 [4598] "Benign_Bone_Neoplasm"                                                                                                                                                 
 [4599] "Metastatic_Neoplasm_to_the_Spine"                                                                                                                                     
 [4600] "Benign_Muscle_Neoplasm"                                                                                                                                               
 [4601] "Malignant_Muscle_Neoplasm"                                                                                                                                            
 [4602] "Benign_Neck_Neoplasm"                                                                                                                                                 
 [4603] "Benign_Pyriform_Fossa_Neoplasm"                                                                                                                                       
 [4604] "Metastatic_Neoplasm_to_the_Trachea"                                                                                                                                   
 [4605] "Benign_Lung_Hilum_Neoplasm"                                                                                                                                           
 [4606] "Metastatic_Neoplasm_to_the_Heart"                                                                                                                                     
 [4607] "Malignant_Gastrointestinal_Neoplasm"                                                                                                                                  
 [4608] "Benign_Submandibular_Gland_Neoplasm"                                                                                                                                  
 [4609] "Stage_0_Small_Intestinal_Cancer"                                                                                                                                      
 [4610] "Benign_Urinary_Tract_Neoplasm"                                                                                                                                        
 [4611] "Benign_Endometrial_Neoplasm"                                                                                                                                          
 [4612] "Benign_Adrenal_Medulla_Neoplasm"                                                                                                                                      
 [4613] "Leukemia_in_Remission"                                                                                                                                                
 [4614] "Acute_Leukemia_in_Remission"                                                                                                                                          
 [4615] "Chronic_Leukemia_in_Remission"                                                                                                                                        
 [4616] "Myeloid_Leukemia_in_Remission"                                                                                                                                        
 [4617] "Monocytic_Leukemia_in_Remission"                                                                                                                                      
 [4618] "Lymphoid_Leukemia_in_Remission"                                                                                                                                       
 [4619] "Benign_Splenic_Neoplasm"                                                                                                                                              
 [4620] "Metastatic_Neoplasm_to_the_Thymus"                                                                                                                                    
 [4621] "Metastatic_Neoplasm_to_Lymph_Nodes"                                                                                                                                   
 [4622] "Hemangioma_of_the_Skin"                                                                                                                                               
 [4623] "Parathyroid_Carcinoma"                                                                                                                                                
 [4624] "Hypertensive_Cardiomegaly"                                                                                                                                            
 [4625] "Ovarian_Carcinoma"                                                                                                                                                    
 [4626] "Cerebral_Edema"                                                                                                                                                       
 [4627] "Colon_Carcinoma"                                                                                                                                                      
 [4628] "Gastric_Carcinoma"                                                                                                                                                    
 [4629] "Bladder_Carcinoma"                                                                                                                                                    
 [4630] "Malignant_Female_Reproductive_System_Neoplasm"                                                                                                                        
 [4631] "Skin_Carcinoma"                                                                                                                                                       
 [4632] "Ependymoblastoma"                                                                                                                                                     
 [4633] "Focal_Nodular_Hyperplasia_of_the_Liver"                                                                                                                               
 [4634] "Small_Cell_Lung_Carcinoma"                                                                                                                                            
 [4635] "Malignant_Nasal_Cavity_Neoplasm"                                                                                                                                      
 [4636] "Rectal_Villous_Adenoma"                                                                                                                                               
 [4637] "Retinal_Capillary_Hemangioma"                                                                                                                                         
 [4638] "Retinal_Cavernous_Hemangioma"                                                                                                                                         
 [4639] "Diverticulosis"                                                                                                                                                       
 [4640] "Glottis_Carcinoma"                                                                                                                                                    
 [4641] "Trichothiodystrophy"                                                                                                                                                  
 [4642] "Malignant_Germ_Cell_Neoplasm"                                                                                                                                         
 [4643] "Metastatic_Malignant_Fibrous_Histiocytoma"                                                                                                                            
 [4644] "Benign_Ovarian_Cyst"                                                                                                                                                  
 [4645] "Acute_Respiratory_Distress_Syndrome"                                                                                                                                  
 [4646] "Chest_Wall_Neoplasm"                                                                                                                                                  
 [4647] "Colon_Hyperplastic_Polyp"                                                                                                                                             
 [4648] "Duodenal_Adenoma"                                                                                                                                                     
 [4649] "Epiglottis_Neoplasm"                                                                                                                                                  
 [4650] "Benign_Female_Reproductive_System_Neoplasm"                                                                                                                           
 [4651] "Ileal_Carcinoid_Tumor"                                                                                                                                                
 [4652] "Hepatic_Granuloma"                                                                                                                                                    
 [4653] "Recurrent_Hodgkin_s_Lymphoma"                                                                                                                                         
 [4654] "Localized_Lymphoma"                                                                                                                                                   
 [4655] "Benign_Lymphoproliferative_Disorder"                                                                                                                                  
 [4656] "Malignant_Neck_Neoplasm"                                                                                                                                              
 [4657] "Soft_Palate_Squamous_Cell_Carcinoma"                                                                                                                                  
 [4658] "Stage_0_Pharyngeal_Cancer"                                                                                                                                            
 [4659] "Pyriform_Fossa_Squamous_Cell_Carcinoma"                                                                                                                               
 [4660] "Sella_Turcica_Neoplasm"                                                                                                                                               
 [4661] "Supraglottic_Squamous_Cell_Carcinoma"                                                                                                                                 
 [4662] "Thyroid_Hurthle_Cell_Carcinoma"                                                                                                                                       
 [4663] "Vaginal_Condyloma_Acuminatum"                                                                                                                                         
 [4664] "Vaginal_Fibroepithelial_Polyp"                                                                                                                                        
 [4665] "Hepatic_Lymphoma"                                                                                                                                                     
 [4666] "Colon_Non-Hodgkin_s_Lymphoma"                                                                                                                                         
 [4667] "Cerebral_Astrocytoma"                                                                                                                                                 
 [4668] "Primary_Brain_Neoplasm"                                                                                                                                               
 [4669] "Intracranial_Neoplasm"                                                                                                                                                
 [4670] "Malignant_Primary_Brain_Neoplasm"                                                                                                                                     
 [4671] "Benign_Cerebellar_Neoplasm"                                                                                                                                           
 [4672] "Desmoplastic_Medulloblastoma"                                                                                                                                         
 [4673] "Benign_Neoplasms_of_the_Meninges"                                                                                                                                     
 [4674] "Leptomeningeal_Neoplasm"                                                                                                                                              
 [4675] "Cerebral_Convexity_Meningioma"                                                                                                                                        
 [4676] "Parasagittal_Meningioma"                                                                                                                                              
 [4677] "Malignant_Peripheral_Nervous_System_Neoplasm"                                                                                                                         
 [4678] "Malignant_Thymus_Neoplasm"                                                                                                                                            
 [4679] "Benign_Supratentorial_Neoplasm"                                                                                                                                       
 [4680] "Malignant_Supratentorial_Neoplasm"                                                                                                                                    
 [4681] "Benign_Infratentorial_Neoplasm"                                                                                                                                       
 [4682] "Malignant_Infratentorial_Neoplasm"                                                                                                                                    
 [4683] "Adult_Acute_Lymphoblastic_Leukemia"                                                                                                                                   
 [4684] "Secondary_Malignant_Neoplasm"                                                                                                                                         
 [4685] "Therapy_Related_Malignant_Neoplasm"                                                                                                                                   
 [4686] "Cerebral_Primitive_Neuroectodermal_Tumor"                                                                                                                             
 [4687] "Malignant_Squamous_Cell_Neoplasm"                                                                                                                                     
 [4688] "Peripheral_Nerve_Sheath_Neoplasm"                                                                                                                                     
 [4689] "Perineurioma"                                                                                                                                                         
 [4690] "Nervous_System_Injury"                                                                                                                                                
 [4691] "Primary_Brain_Stem_Neoplasm"                                                                                                                                          
 [4692] "Central_Nervous_System_Vascular_Malformation"                                                                                                                         
 [4693] "Rathke_Pouch_Cyst"                                                                                                                                                    
 [4694] "Malignant_Colorectal_Neoplasm"                                                                                                                                        
 [4695] "Primary_Carcinoma_Unspecified_Site"                                                                                                                                   
 [4696] "Acute_Graft_Versus_Host_Disease"                                                                                                                                      
 [4697] "Chronic_Graft_Versus_Host_Disease"                                                                                                                                    
 [4698] "Aleukemic_Leukemia"                                                                                                                                                   
 [4699] "Aleukemic_Leukemia_Cutis"                                                                                                                                             
 [4700] "Ovarian_Neoplasm"                                                                                                                                                     
 [4701] "Oropharyngeal_Candidiasis"                                                                                                                                            
 [4702] "AIDS_in_Hemophiliac_Population"                                                                                                                                       
 [4703] "AIDS_Associated_Opportunistic_Infections"                                                                                                                             
 [4704] "Childhood_Leukemia"                                                                                                                                                   
 [4705] "Diseases_Associated_with_AIDS"                                                                                                                                        
 [4706] "Environment-Related_Malignant_Neoplasm"                                                                                                                               
 [4707] "Occupational_Malignant_Neoplasm"                                                                                                                                      
 [4708] "Stage_II_Bladder_Squamous_Cell_Carcinoma"                                                                                                                             
 [4709] "Recurrent_Bladder_Adenocarcinoma"                                                                                                                                     
 [4710] "Stage_I_Extragonadal_Primary_Seminoma"                                                                                                                                
 [4711] "Refractory_Nodal_Marginal_Zone_B-Cell_Lymphoma"                                                                                                                       
 [4712] "Recurrent_Nodal_Marginal_Zone_B-Cell_Lymphoma"                                                                                                                        
 [4713] "Stage_IV_High-Grade_Burkitt-Like_Lymphoma"                                                                                                                            
 [4714] "Stage_III_High-Grade_Burkitt-Like_Lymphoma"                                                                                                                           
 [4715] "Stage_II_High-Grade_Burkitt-Like_Lymphoma"                                                                                                                            
 [4716] "Stage_I_High-Grade_Burkitt-Like_Lymphoma"                                                                                                                             
 [4717] "Refractory_High-Grade_Burkitt-Like_Lymphoma"                                                                                                                          
 [4718] "Recurrent_High-Grade_Burkitt-Like_Lymphoma"                                                                                                                           
 [4719] "High-Grade_Burkitt-Like_Lymphoma"                                                                                                                                     
 [4720] "Stage_IV_Follicular_Lymphoma"                                                                                                                                         
 [4721] "Recurrent_Follicular_Lymphoma"                                                                                                                                        
 [4722] "Recurrent_Burkitt_s_Lymphoma"                                                                                                                                         
 [4723] "Stage_II_Supradiaphragmatic_Hodgkin_s_Lymphoma"                                                                                                                       
 [4724] "Stage_II_Subdiaphragmatic_Hodgkin_s_Lymphoma"                                                                                                                         
 [4725] "Stage_I_Supradiaphragmatic_Hodgkin_s_Lymphoma"                                                                                                                        
 [4726] "Stage_I_Subdiaphragmatic_Hodgkin_s_Lymphoma"                                                                                                                          
 [4727] "Recurrent_Squamous_Cell_Lung_Carcinoma"                                                                                                                               
 [4728] "Stage_II_Rectosigmoid_Cancer"                                                                                                                                         
 [4729] "Stage_I_Rectosigmoid_Cancer"                                                                                                                                          
 [4730] "Stage_0_Rectosigmoid_Cancer"                                                                                                                                          
 [4731] "Unresectable_Pancreatic_Cancer"                                                                                                                                       
 [4732] "Stage_IV_Esophageal_Squamous_Cell_Carcinoma"                                                                                                                          
 [4733] "Stage_III_Esophageal_Squamous_Cell_Carcinoma"                                                                                                                         
 [4734] "Stage_II_Esophageal_Squamous_Cell_Carcinoma"                                                                                                                          
 [4735] "Stage_I_Esophageal_Squamous_Cell_Carcinoma"                                                                                                                           
 [4736] "Stage_0_Esophageal_Squamous_Cell_Carcinoma"                                                                                                                           
 [4737] "Prostate_Carcinoid_Tumor"                                                                                                                                             
 [4738] "Recurrent_Nasal_Type_NK_T-Cell_Lymphoma"                                                                                                                              
 [4739] "Malignant_Testicular_Non-Seminomatous_Germ_Cell_Tumor"                                                                                                                
 [4740] "Benign_Verrucous_Lesion"                                                                                                                                              
 [4741] "Bile_Duct_Sarcoma"                                                                                                                                                    
 [4742] "Endocrine_System_Signs_and_Symptoms"                                                                                                                                  
 [4743] "Disturbance_in_Bowel_Function"                                                                                                                                        
 [4744] "Genitourinary_Signs_and_Symptoms"                                                                                                                                     
 [4745] "Integumentary_System_Signs_and_Symptoms"                                                                                                                              
 [4746] "Alterations_in_Hearing"                                                                                                                                               
 [4747] "Alterations_in_Smell_or_Taste"                                                                                                                                        
 [4748] "Motor_Manifestations"                                                                                                                                                 
 [4749] "Sensory_Manifestations"                                                                                                                                               
 [4750] "Speech_Manifestations"                                                                                                                                                
 [4751] "Visual_Manifestations"                                                                                                                                                
 [4752] "Ventilation_or_Perfusion_Signs_and_Symptoms"                                                                                                                          
 [4753] "Fluid_and_Electrolyte_Manifestation"                                                                                                                                  
 [4754] "AIDS-Related_Malignant_Anal_Neoplasm"                                                                                                                                 
 [4755] "AIDS-Related_Non-Hodgkin_s_Lymphoma"                                                                                                                                  
 [4756] "AIDS-Related_Malignant_Cervical_Neoplasm"                                                                                                                             
 [4757] "Childhood_Testicular_Neoplasm"                                                                                                                                        
 [4758] "Primary_Cerebral_Lymphoma_in_Immunocompetent_Host"                                                                                                                    
 [4759] "Cerebral_Hodgkin_s_Lymphoma"                                                                                                                                          
 [4760] "Primary_Cerebral_Hodgkin_s_Lymphoma"                                                                                                                                  
 [4761] "Secondary_Cerebral_Hodgkin_s_Lymphoma"                                                                                                                                
 [4762] "Recurrent_Epithelioid_Sarcoma"                                                                                                                                        
 [4763] "Primary_Fibrosarcoma"                                                                                                                                                 
 [4764] "Urethral_Papilloma"                                                                                                                                                   
 [4765] "Cancer_Fatigue"                                                                                                                                                       
 [4766] "Endobronchial_Lipoma"                                                                                                                                                 
 [4767] "Stage_I_Lymphocyte_Depleted_Hodgkin_s_Lymphoma"                                                                                                                       
 [4768] "Stage_I_Subdiaphragmatic_Lymphocyte_Depleted_Hodgkin_s_Lymphoma"                                                                                                      
 [4769] "Stage_I_Supradiaphragmatic_Lymphocyte_Depleted_Hodgkin_s_Lymphoma"                                                                                                    
 [4770] "Stage_II_Lymphocyte_Depleted_Hodgkin_s_Lymphoma"                                                                                                                      
 [4771] "Stage_II_Subdiaphragmatic_Lymphocyte_Depleted_Hodgkin_s_Lymphoma"                                                                                                     
 [4772] "Stage_II_Supradiaphragmatic_Lymphocyte_Depleted_Hodgkin_s_Lymphoma"                                                                                                   
 [4773] "Stage_II_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma"                                                                                                           
 [4774] "Stage_II_Subdiaphragmatic_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma"                                                                                          
 [4775] "Stage_II_Supradiaphragmatic_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma"                                                                                        
 [4776] "Stage_I_Subdiaphragmatic_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma"                                                                                           
 [4777] "Stage_I_Supradiaphragmatic_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma"                                                                                         
 [4778] "Stage_I_Subdiaphragmatic_Mixed_Cellularity_Hodgkin_s_Lymphoma"                                                                                                        
 [4779] "Stage_I_Supradiaphragmatic_Mixed_Cellularity_Hodgkin_s_Lymphoma"                                                                                                      
 [4780] "Stage_II_Mixed_Cellularity_Hodgkin_s_Lymphoma"                                                                                                                        
 [4781] "Stage_II_Subdiaphragmatic_Mixed_Cellularity_Hodgkin_s_Lymphoma"                                                                                                       
 [4782] "Stage_I_Subdiaphragmatic_Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                        
 [4783] "Stage_I_Supradiaphragmatic_Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                      
 [4784] "Stage_II_Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                                        
 [4785] "Stage_II_Subdiaphragmatic_Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                       
 [4786] "Stage_II_Supradiaphragmatic_Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                     
 [4787] "Stage_IV_Burkitt_s_Lymphoma"                                                                                                                                          
 [4788] "Stage_I_Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue"                                                                                
 [4789] "Stage_II_Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue"                                                                               
 [4790] "Stage_III_Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue"                                                                              
 [4791] "Stage_IV_Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue"                                                                               
 [4792] "Recurrent_Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue"                                                                              
 [4793] "Refractory_Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue"                                                                             
 [4794] "Stage_I_Splenic_Marginal_Zone_B-Cell_Lymphoma"                                                                                                                        
 [4795] "Stage_II_Splenic_Marginal_Zone_B-Cell_Lymphoma"                                                                                                                       
 [4796] "Stage_III_Splenic_Marginal_Zone_B-Cell_Lymphoma"                                                                                                                      
 [4797] "Stage_IV_Splenic_Marginal_Zone_B-Cell_Lymphoma"                                                                                                                       
 [4798] "Recurrent_Splenic_Marginal_Zone_B-Cell_Lymphoma"                                                                                                                      
 [4799] "Refractory_Splenic_Marginal_Zone_B-Cell_Lymphoma"                                                                                                                     
 [4800] "Brain_Stem_Glioblastoma"                                                                                                                                              
 [4801] "Brain_Stem_Ependymoma"                                                                                                                                                
 [4802] "Resectable_Pancreatic_Cancer"                                                                                                                                         
 [4803] "Renal_Fibroma"                                                                                                                                                        
 [4804] "Renal_Lipoma"                                                                                                                                                         
 [4805] "Lacrimal_System_Neoplasm"                                                                                                                                             
 [4806] "Recurrent_Pharyngeal_Cancer"                                                                                                                                          
 [4807] "Stage_II_Supradiaphragmatic_Mixed_Cellularity_Hodgkin_s_Lymphoma"                                                                                                     
 [4808] "Colorectal_Adenocarcinoma"                                                                                                                                            
 [4809] "Intestinal_Graft_Versus_Host_Disease"                                                                                                                                 
 [4810] "BMT_Nephropathy"                                                                                                                                                      
 [4811] "Benign_Intracranial_Neoplasm"                                                                                                                                         
 [4812] "Autonomic_Nervous_System_Neoplasm"                                                                                                                                    
 [4813] "Malignant_Intracranial_Neoplasm"                                                                                                                                      
 [4814] "Malignant_Adult_Brain_Neoplasm"                                                                                                                                       
 [4815] "Benign_Adult_Brain_Neoplasm"                                                                                                                                          
 [4816] "Malignant_Eccrine_Spiradenoma"                                                                                                                                        
 [4817] "Benign_Schwannoma"                                                                                                                                                    
 [4818] "Nerve_Root_Neoplasm"                                                                                                                                                  
 [4819] "Vestibulocochlear_Nerve_Neoplasm"                                                                                                                                     
 [4820] "Olfactory_Nerve_Neoplasm"                                                                                                                                             
 [4821] "Trigeminal_Nerve_Neoplasm"                                                                                                                                            
 [4822] "Anaplastic_Hemispheric_Astrocytoma"                                                                                                                                   
 [4823] "Anaplastic_Diencephalic_Astrocytoma"                                                                                                                                  
 [4824] "Diencephalic_Neoplasm"                                                                                                                                                
 [4825] "Malignant_Diencephalic_Neoplasm"                                                                                                                                      
 [4826] "Benign_Diencephalic_Neoplasm"                                                                                                                                         
 [4827] "Diencephalic_Astrocytoma"                                                                                                                                             
 [4828] "Diencephalic_Glioblastoma"                                                                                                                                            
 [4829] "Adenoid_Cystic_Breast_Carcinoma"                                                                                                                                      
 [4830] "Adult_Central_Nervous_System_Neoplasm"                                                                                                                                
 [4831] "Childhood_Central_Nervous_System_Neoplasm"                                                                                                                            
 [4832] "Benign_Intracranial_Meningioma"                                                                                                                                       
 [4833] "Intraspinal_Meningioma"                                                                                                                                               
 [4834] "Intradural_Extramedullary_Spinal_Canal_Neoplasm"                                                                                                                      
 [4835] "Childhood_Glioblastoma"                                                                                                                                               
 [4836] "Intraductal_Non-Comedo_Breast_Adenocarcinoma"                                                                                                                         
 [4837] "Intraductal_Cribriform_Breast_Adenocarcinoma"                                                                                                                         
 [4838] "Intraductal_Micropapillary_Breast_Carcinoma"                                                                                                                          
 [4839] "Apocrine_Breast_Carcinoma_in_situ"                                                                                                                                    
 [4840] "Apocrine_Ductal_Breast_Carcinoma"                                                                                                                                     
 [4841] "Invasive_Cribriform_Breast_Carcinoma"                                                                                                                                 
 [4842] "Malignant_Breast_Adenomyoepithelioma"                                                                                                                                 
 [4843] "Benign_Breast_Adenomyoepithelioma"                                                                                                                                    
 [4844] "Spinal_Cord_Neurofibroma"                                                                                                                                             
 [4845] "Cerebellar_Hemangioblastoma"                                                                                                                                          
 [4846] "Brain_Stem_Hemangioblastoma"                                                                                                                                          
 [4847] "Infratentorial_Glioblastoma"                                                                                                                                          
 [4848] "Supratentorial_Glioblastoma"                                                                                                                                          
 [4849] "Cerebellar_Glioblastoma"                                                                                                                                              
 [4850] "Cerebral_Glioblastoma"                                                                                                                                                
 [4851] "Spinal_Cord_Sarcoma"                                                                                                                                                  
 [4852] "Central_Nervous_System_Sarcoma"                                                                                                                                       
 [4853] "Brain_Sarcoma"                                                                                                                                                        
 [4854] "Spinal_Cord_Neuroblastoma"                                                                                                                                            
 [4855] "Spinal_Chordoma"                                                                                                                                                      
 [4856] "Spinal_Cord_Lymphoma"                                                                                                                                                 
 [4857] "Spinal_Cord_Melanoma"                                                                                                                                                 
 [4858] "Mixed_Lobular_and_Ductal_Breast_Carcinoma"                                                                                                                            
 [4859] "Undifferentiated_Breast_Carcinoma"                                                                                                                                    
 [4860] "Breast_Adenocarcinoma_with_Squamous_Metaplasia"                                                                                                                       
 [4861] "Metaplastic_Breast_Carcinoma"                                                                                                                                         
 [4862] "Childhood_Lymphoma"                                                                                                                                                   
 [4863] "Mucoepidermoid_Breast_Carcinoma"                                                                                                                                      
 [4864] "High-Grade_Mucoepidermoid_Breast_Carcinoma"                                                                                                                           
 [4865] "Low-Grade_Mucoepidermoid_Breast_Carcinoma"                                                                                                                            
 [4866] "Breast_Neuroendocrine_Neoplasm"                                                                                                                                       
 [4867] "Carcinoid_Tumor_of_the_Breast"                                                                                                                                        
 [4868] "Metastatic_Breast_Carcinoid_Tumor"                                                                                                                                    
 [4869] "Primary_Breast_Carcinoid_Tumor"                                                                                                                                       
 [4870] "Breast_Apocrine_Carcinoma"                                                                                                                                            
 [4871] "Signet_Ring_Cell_Breast_Carcinoma"                                                                                                                                    
 [4872] "Metastatic_Signet_Ring_Cell_Breast_Carcinoma"                                                                                                                         
 [4873] "Squamous_Cell_Breast_Carcinoma"                                                                                                                                       
 [4874] "Metastatic_Squamous_Cell_Breast_Carcinoma"                                                                                                                            
 [4875] "Primary_Squamous_Cell_Breast_Carcinoma"                                                                                                                               
 [4876] "Malignant_Breast_Eccrine_Spiradenoma"                                                                                                                                 
 [4877] "Primary_Non-Hodgkin_s_Breast_Lymphoma"                                                                                                                                
 [4878] "Primary_T-Cell_Breast_Lymphoma"                                                                                                                                       
 [4879] "Hereditary_Multiple_Exostoses"                                                                                                                                        
 [4880] "Breast_Angiosarcoma"                                                                                                                                                  
 [4881] "Breast_Fibrosarcoma"                                                                                                                                                  
 [4882] "Breast_Leiomyosarcoma"                                                                                                                                                
 [4883] "Breast_Liposarcoma"                                                                                                                                                   
 [4884] "Osteosarcoma_of_the_Breast"                                                                                                                                           
 [4885] "Breast_Rhabdomyosarcoma"                                                                                                                                              
 [4886] "Benign_Eccrine_Breast_Spiradenoma"                                                                                                                                    
 [4887] "Complex_Breast_Fibroadenoma"                                                                                                                                          
 [4888] "Atypical_Hyperplasia_of_the_Breast"                                                                                                                                   
 [4889] "Benign_Phyllodes_Tumor_of_the_Breast"                                                                                                                                 
 [4890] "Benign_Nipple_Neoplasm"                                                                                                                                               
 [4891] "Apocrine_Breast_Adenosis"                                                                                                                                             
 [4892] "Microglandular_Breast_Adenosis"                                                                                                                                       
 [4893] "Papillary_Ductal_Breast_Hyperplasia"                                                                                                                                  
 [4894] "Intraductal_Breast_Papillomatosis"                                                                                                                                    
 [4895] "Non-Proliferating_Breast_Lesion"                                                                                                                                      
 [4896] "Proliferating_Breast_Lesion_without_Atypia"                                                                                                                           
 [4897] "Sclerosing_Adenosis_of_the_Breast"                                                                                                                                    
 [4898] "Papillary_Breast_Neoplasm"                                                                                                                                            
 [4899] "Vascular_Breast_Neoplasm"                                                                                                                                             
 [4900] "Breast_Capillary_Hemangioma"                                                                                                                                          
 [4901] "Breast_Epithelioid_Hemangioma"                                                                                                                                        
 [4902] "Nipple_Neoplasm"                                                                                                                                                      
 [4903] "Malignant_Nipple_Neoplasm"                                                                                                                                            
 [4904] "Breast_Adenocarcinoma"                                                                                                                                                
 [4905] "Complex_Ovarian_Cyst"                                                                                                                                                 
 [4906] "Functional_Ovarian_Cyst"                                                                                                                                              
 [4907] "Retention_Ovarian_Cyst"                                                                                                                                               
 [4908] "Unilocular_Ovarian_Cyst"                                                                                                                                              
 [4909] "Benign_Ovarian_Thecoma"                                                                                                                                               
 [4910] "Stage_IA_Ovarian_Cancer"                                                                                                                                              
 [4911] "Stage_IB_Ovarian_Cancer"                                                                                                                                              
 [4912] "Stage_IC_Ovarian_Cancer"                                                                                                                                              
 [4913] "Stage_IIA_Ovarian_Cancer"                                                                                                                                             
 [4914] "Stage_IIB_Ovarian_Cancer"                                                                                                                                             
 [4915] "Stage_IIC_Ovarian_Cancer"                                                                                                                                             
 [4916] "Borderline_Ovarian_Serous_Neoplasm"                                                                                                                                   
 [4917] "Ovarian_Cystadenocarcinoma"                                                                                                                                           
 [4918] "Ovarian_Carcinoid_Tumor"                                                                                                                                              
 [4919] "Ovarian_Stromal_Luteoma"                                                                                                                                              
 [4920] "Ovarian_Leydig_Cell_Tumor"                                                                                                                                            
 [4921] "Ovarian_Angiosarcoma"                                                                                                                                                 
 [4922] "Ovarian_Fibrosarcoma"                                                                                                                                                 
 [4923] "Ovarian_Leiomyosarcoma"                                                                                                                                               
 [4924] "Ovarian_Myxoid_Liposarcoma"                                                                                                                                           
 [4925] "Ovarian_Rhabdomyosarcoma"                                                                                                                                             
 [4926] "Ovarian_Neuroendocrine_Neoplasm"                                                                                                                                      
 [4927] "Ovarian_Non-Small-Cell_Type_Neuroendocrine_Carcinoma"                                                                                                                 
 [4928] "Ovarian_Transitional_Cell_Carcinoma"                                                                                                                                  
 [4929] "Mixed_Germ_Cell-Sex_Cord-Stromal_Tumor"                                                                                                                               
 [4930] "Ovarian_Mucinous_Neoplasm"                                                                                                                                            
 [4931] "Ovarian_Mucinous_Adenocarcinoma"                                                                                                                                      
 [4932] "Ovarian_Soft_Tissue_Neoplasm"                                                                                                                                         
 [4933] "Ovarian_Myxoma"                                                                                                                                                       
 [4934] "Benign_Ovarian_Partly_Luteinized_Thecoma"                                                                                                                             
 [4935] "Gastric_Cardia_Adenocarcinoma"                                                                                                                                        
 [4936] "Mucinous_Gastric_Adenocarcinoma"                                                                                                                                      
 [4937] "Signet_Ring_Cell_Gastric_Adenocarcinoma"                                                                                                                              
 [4938] "Primary_Gastric_Burkitt_s_Lymphoma"                                                                                                                                   
 [4939] "Primary_Gastric_Diffuse_Large_B-Cell_Lymphoma"                                                                                                                        
 [4940] "Primary_Gastric_T-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                        
 [4941] "Immature_Gastric_Teratoma"                                                                                                                                            
 [4942] "Gastric_Lipoma"                                                                                                                                                       
 [4943] "Gastric_Teratoma"                                                                                                                                                     
 [4944] "Mature_Gastric_Teratoma"                                                                                                                                              
 [4945] "Childhood_Acute_Lymphoblastic_Leukemia_in_Partial_Remission"                                                                                                          
 [4946] "Childhood_Acute_Lymphoblastic_Leukemia_in_Complete_Remission"                                                                                                         
 [4947] "Gene_Exchanges"                                                                                                                                                       
 [4948] "Bronchial_Mucosa-Associated_Lymphoid_Tissue_Lymphoma"                                                                                                                 
 [4949] "Thyroid_Lymphoma"                                                                                                                                                     
 [4950] "Gastric_Mucosa-Associated_Lymphoid_Tissue_Lymphoma"                                                                                                                   
 [4951] "Falx_Meningioma"                                                                                                                                                      
 [4952] "Cavernous_Sinus_Meningioma"                                                                                                                                           
 [4953] "Intracerebral_Cystic_Meningioma"                                                                                                                                      
 [4954] "Cerebellar_Papillary_Meningioma"                                                                                                                                      
 [4955] "Petrous_Apex_Meningioma"                                                                                                                                              
 [4956] "Skull_Base_Meningioma"                                                                                                                                                
 [4957] "Intraventricular_Meningioma"                                                                                                                                          
 [4958] "Metastatic_Meningioma"                                                                                                                                                
 [4959] "Multiple_Intraspinal_Meningiomas"                                                                                                                                     
 [4960] "Primary_Lung_Meningioma"                                                                                                                                              
 [4961] "Primary_Cutaneous_Meningioma"                                                                                                                                         
 [4962] "Petroclival_Meningioma"                                                                                                                                               
 [4963] "Multiple_Skull_Base_Meningioma"                                                                                                                                       
 [4964] "Foramen_Magnum_Meningioma"                                                                                                                                            
 [4965] "Anterior_Foramen_Magnum_Meningioma"                                                                                                                                   
 [4966] "Posterior_Foramen_Magnum_Meningioma"                                                                                                                                  
 [4967] "Diaphragma_Sellae_Meningioma"                                                                                                                                         
 [4968] "Tuberculum_Sellae_Meningioma"                                                                                                                                         
 [4969] "Sphenoorbital_Meningioma"                                                                                                                                             
 [4970] "Anterior_Cranial_Fossa_Meningioma"                                                                                                                                    
 [4971] "Spinal_Multifocal_Clear_Cell_Meningioma"                                                                                                                              
 [4972] "Lower_Clivus_Meningioma"                                                                                                                                              
 [4973] "Clivus_Meningioma"                                                                                                                                                    
 [4974] "Upper_Clivus_Meningioma"                                                                                                                                              
 [4975] "Radiation-Induced_Intracranial_Meningioma"                                                                                                                            
 [4976] "Frontal_Convexity_Meningioma"                                                                                                                                         
 [4977] "Jugular_Foramen_Meningioma"                                                                                                                                           
 [4978] "Deletions_of_the_Short_Arm_of_Chromosome_1_1p_Associated_Meningiomas"                                                                                                 
 [4979] "Brain_Stem_Intraparenchymal_Clear_Cell_Meningioma"                                                                                                                    
 [4980] "Cervical_Intraspinal_Meningioma"                                                                                                                                      
 [4981] "Thoracic_Intraspinal_Meningioma"                                                                                                                                      
 [4982] "Lumbar_Intraspinal_Meningioma"                                                                                                                                        
 [4983] "Sacral_Intraspinal_Meningioma"                                                                                                                                        
 [4984] "Cerebellopontine_Angle_Meningioma"                                                                                                                                    
 [4985] "Hereditary_Meningioma"                                                                                                                                                
 [4986] "Lateral_Ventricle_Meningioma"                                                                                                                                         
 [4987] "Parapharyngeal_Meningioma"                                                                                                                                            
 [4988] "Bilateral_Optic_Nerve_Meningioma"                                                                                                                                     
 [4989] "Deletions_of_Chromosome_22_Associated_Meningiomas"                                                                                                                    
 [4990] "Deletions_of_Chromosome_3p_Associated_Meningiomas"                                                                                                                    
 [4991] "Internal_Auditory_Canal_Meningioma"                                                                                                                                   
 [4992] "Ectopic_Meningioma"                                                                                                                                                   
 [4993] "Ethmoid_Sinus_Primary_Ectopic_Meningioma"                                                                                                                             
 [4994] "Epidural_Spinal_Canal_Meningioma"                                                                                                                                     
 [4995] "Pituitary_Stalk_Meningioma"                                                                                                                                           
 [4996] "Recurrent_Meningioma"                                                                                                                                                 
 [4997] "Sphenocavernous_Meningioma"                                                                                                                                           
 [4998] "Primary_Low-Grade_B-Cell_Dural_Lymphoma"                                                                                                                              
 [4999] "Breast_Cyst"                                                                                                                                                          
 [5000] "Borderline_Breast_Phyllodes_Tumor"                                                                                                                                    
 [5001] "Leptomeningeal_Melanoma"                                                                                                                                              
 [5002] "Childhood_Leptomeningeal_Melanoma"                                                                                                                                    
 [5003] "Adult_Leptomeningeal_Melanoma"                                                                                                                                        
 [5004] "Peripheral_Intraneural_Angiosarcoma"                                                                                                                                  
 [5005] "Macrocystic_Schwannoma"                                                                                                                                               
 [5006] "Primary_Central_Nervous_System_Anaplastic_Large_Cell_Lymphoma"                                                                                                        
 [5007] "Jugular_Foramen_Schwannoma"                                                                                                                                           
 [5008] "Cauda_Equina_Paraganglioma"                                                                                                                                           
 [5009] "Intestinal_Paraganglioma"                                                                                                                                             
 [5010] "Intra-Abdominal_Paraganglioma"                                                                                                                                        
 [5011] "Head_and_Neck_Paraganglioma"                                                                                                                                          
 [5012] "Extra-Adrenal_Retroperitoneal_Paragangliomas"                                                                                                                         
 [5013] "Hereditary_Paraganglioma"                                                                                                                                             
 [5014] "Distraction"                                                                                                                                                          
 [5015] "Treatment-Induced_Anemia"                                                                                                                                             
 [5016] "Esophageal_Leiomyosarcoma"                                                                                                                                            
 [5017] "Small_Intestinal_Sarcoma"                                                                                                                                             
 [5018] "Small_Intestinal_Fibrosarcoma"                                                                                                                                        
 [5019] "Small_Intestinal_Hodgkin_s_Lymphoma"                                                                                                                                  
 [5020] "Duodenal_Villous_Adenoma"                                                                                                                                             
 [5021] "Small_Intestinal_Lipoma"                                                                                                                                              
 [5022] "Small_Intestinal_Adenoma"                                                                                                                                             
 [5023] "Esophageal_Sarcoma"                                                                                                                                                   
 [5024] "Esophageal_Adenoid_Cystic_Carcinoma"                                                                                                                                  
 [5025] "Esophageal_Mucoepidermoid_Carcinoma"                                                                                                                                  
 [5026] "Esophageal_Squamous_Cell_Papilloma"                                                                                                                                   
 [5027] "Telangiectatic_Glomangioma"                                                                                                                                           
 [5028] "Endocardial_Neoplasm"                                                                                                                                                 
 [5029] "Epicardial_Neoplasm"                                                                                                                                                  
 [5030] "Great_Vessel_Neoplasm"                                                                                                                                                
 [5031] "Myocardial_Neoplasm"                                                                                                                                                  
 [5032] "Hereditary_Glomangioma"                                                                                                                                               
 [5033] "Metastatic_Jugulotympanic_Paraganglioma"                                                                                                                              
 [5034] "Benign_Orbit_Hemangiopericytoma"                                                                                                                                      
 [5035] "Breast_Hemangioma"                                                                                                                                                    
 [5036] "Cutaneous_Vascular_Neoplasm"                                                                                                                                          
 [5037] "Intravascular_Angiomyoma"                                                                                                                                             
 [5038] "Intravascular_Leiomyomatosis_of_the_Uterus"                                                                                                                           
 [5039] "Benign_Cardiac_Germ_Cell_Neoplasm"                                                                                                                                    
 [5040] "Benign_Cardiac_Schwannoma"                                                                                                                                            
 [5041] "Cardiac_Neurofibroma"                                                                                                                                                 
 [5042] "Cardiac_Granular_Cell_Tumor"                                                                                                                                          
 [5043] "Cardiac_Fibrosarcoma"                                                                                                                                                 
 [5044] "Cardiac_Hemangioendothelioma"                                                                                                                                         
 [5045] "Cardiac_Kaposi_s_Sarcoma"                                                                                                                                             
 [5046] "Cardiac_Leiomyosarcoma"                                                                                                                                               
 [5047] "Malignant_Cardiac_Hemangiopericytoma"                                                                                                                                 
 [5048] "Malignant_Cardiac_Peripheral_Nerve_Sheath_Tumor"                                                                                                                      
 [5049] "Cardiac_Lymphoma"                                                                                                                                                     
 [5050] "Secondary_Lymphoma_of_Heart"                                                                                                                                          
 [5051] "Heart_Myeloid_Sarcoma"                                                                                                                                                
 [5052] "Malignant_Cardiac_Germ_Cell_Neoplasm"                                                                                                                                 
 [5053] "Inferior_Vena_Cava_Leiomyosarcoma"                                                                                                                                    
 [5054] "Pulmonary_Artery_Leiomyosarcoma"                                                                                                                                      
 [5055] "Pulmonary_Vein_Leiomyosarcoma"                                                                                                                                        
 [5056] "Malignant_Aortic_Neoplasm"                                                                                                                                            
 [5057] "Aortic_Angiosarcoma"                                                                                                                                                  
 [5058] "Malignant_Inferior_Vena_Cava_Neoplasm"                                                                                                                                
 [5059] "Superior_Vena_Cava_Angiosarcoma"                                                                                                                                      
 [5060] "Malignant_Superior_Vena_Cava_Neoplasm"                                                                                                                                
 [5061] "Malignant_Pulmonary_Artery_Neoplasm"                                                                                                                                  
 [5062] "Pulmonary_Artery_Choriocarcinoma"                                                                                                                                     
 [5063] "Malignant_Pulmonary_Vein_Neoplasm"                                                                                                                                    
 [5064] "Recurrent_Angiosarcoma"                                                                                                                                               
 [5065] "Uterine_Angiosarcoma"                                                                                                                                                 
 [5066] "Retroperitoneal_Hemangiopericytoma"                                                                                                                                   
 [5067] "Vascular_Leiomyosarcoma"                                                                                                                                              
 [5068] "Renal_Vein_Leiomyosarcoma"                                                                                                                                            
 [5069] "Benign_Atrial_Neoplasm"                                                                                                                                               
 [5070] "Atrial_Paraganglioma"                                                                                                                                                 
 [5071] "Malignant_Cardiac_Paraganglioma"                                                                                                                                      
 [5072] "Parotid_Gland_Lymphangioma"                                                                                                                                           
 [5073] "Solitary_Adult_Fibroma"                                                                                                                                               
 [5074] "Colon_Cavernous_Hemangioma"                                                                                                                                           
 [5075] "Bone_Epithelioid_Hemangioma"                                                                                                                                          
 [5076] "Parotid_Gland_Hemangioma"                                                                                                                                             
 [5077] "Central_Nervous_System_Primitive_Neuroectodermal_Tumor"                                                                                                               
 [5078] "Medulloblastoma_with_Leptomeningeal_Spread"                                                                                                                           
 [5079] "Primitive_Neuroectodermal_Tumor_with_Leptomeningeal_Spread"                                                                                                           
 [5080] "Cerebellar_Vermis_Medulloblastoma"                                                                                                                                    
 [5081] "Region_17p13_Allelic_Loss_Associated_Medulloblastomas"                                                                                                                
 [5082] "Malignant_Intracranial_Germ_Cell_Neoplasm"                                                                                                                            
 [5083] "Nevoid_Basal_Cell_Carcinoma_Syndrome_Associated_Medulloblastoma"                                                                                                      
 [5084] "Spinal_Cord_Primitive_Neuroectodermal_Neoplasm"                                                                                                                       
 [5085] "Nodular_Medulloblastoma"                                                                                                                                              
 [5086] "Intradural_Extramedullary_Cauda_Equina_Astrocytoma"                                                                                                                   
 [5087] "Central_Nervous_System_T-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                 
 [5088] "Primary_Intraocular_Lymphoma"                                                                                                                                         
 [5089] "Adult_Central_Nervous_System_Primitive_Neuroectodermal_Tumor"                                                                                                         
 [5090] "Clival_Chordoma"                                                                                                                                                      
 [5091] "Cerebellopontine_Angle_Schwannoma"                                                                                                                                    
 [5092] "Cerebellopontine_Angle_Neoplasm"                                                                                                                                      
 [5093] "Multiple_Spinal_Meningeal_Cysts"                                                                                                                                      
 [5094] "Anaplastic_Secondary_Supratentorial_Astrocytoma"                                                                                                                      
 [5095] "Pineal_Gland_Epidermoid_Cyst"                                                                                                                                         
 [5096] "Pleural_Schwannoma"                                                                                                                                                   
 [5097] "Gliofibroma"                                                                                                                                                          
 [5098] "Paraneoplastic_Subacute_Sensory_Neuronopathy"                                                                                                                         
 [5099] "Sympathetic_Schwannoma"                                                                                                                                               
 [5100] "Cervicomedullary_Junction_Neoplasm"                                                                                                                                   
 [5101] "Epidural_Spinal_Canal_Angiolipoma"                                                                                                                                    
 [5102] "Clivus_Chondroid_Chordoma"                                                                                                                                            
 [5103] "Retroperitoneal_Ganglioneuroma"                                                                                                                                       
 [5104] "Intramedullary_Spinal_Cord_Teratoma"                                                                                                                                  
 [5105] "Childhood_Mediastinal_Neurogenic_Neoplasm"                                                                                                                            
 [5106] "Intracranial_Germinoma"                                                                                                                                               
 [5107] "Peripheral_Nerve_Fibrolipomatous_Hamartoma"                                                                                                                           
 [5108] "Intracranial_Cavernous_Hemangioma"                                                                                                                                    
 [5109] "Cerebral_Hemangioma"                                                                                                                                                  
 [5110] "Schwannoma_of_the_Twelfth_Cranial_Nerve"                                                                                                                              
 [5111] "Kadish_Stage_C_Olfactory_Neuroblastoma"                                                                                                                               
 [5112] "Cerebellopontine_Angle_Primitive_Neuroectodermal_Tumor"                                                                                                               
 [5113] "Extracranial_Neuroblastoma"                                                                                                                                           
 [5114] "Corpus_Callosum_Lipoma"                                                                                                                                               
 [5115] "Drop_Metastasis_to_Spinal_Cord"                                                                                                                                       
 [5116] "Central_Nervous_System_Leukemia"                                                                                                                                      
 [5117] "Central_Nervous_System_Teratoma"                                                                                                                                      
 [5118] "Intracranial_Melanoma"                                                                                                                                                
 [5119] "Conus_Medullaris_Neoplasm"                                                                                                                                            
 [5120] "Intracranial_Lipoma"                                                                                                                                                  
 [5121] "Central_Nervous_System_Colloid_Cyst"                                                                                                                                  
 [5122] "Meningeal_Gliomatosis"                                                                                                                                                
 [5123] "Childhood_Anaplastic_Oligodendroglioma"                                                                                                                               
 [5124] "Malignant_Childhood_Central_Nervous_System_Neoplasm"                                                                                                                  
 [5125] "Central_Nervous_System_Soft_Tissue_Neoplasm"                                                                                                                          
 [5126] "Central_Nervous_System_Angiosarcoma"                                                                                                                                  
 [5127] "Central_Nervous_System_Lipoma"                                                                                                                                        
 [5128] "Internal_Auditory_Canal_Lipoma"                                                                                                                                       
 [5129] "Skull_Base_Chordoma"                                                                                                                                                  
 [5130] "Stage_IIA_Breast_Cancer"                                                                                                                                              
 [5131] "Stage_IIB_Breast_Cancer"                                                                                                                                              
 [5132] "Tubular_Breast_Adenosis"                                                                                                                                              
 [5133] "Invasive_Apocrine_Breast_Carcinoma"                                                                                                                                   
 [5134] "Malignant_Mixed_Breast_Neoplasm"                                                                                                                                      
 [5135] "Central_Nervous_System_Germ_Cell_Neoplasm"                                                                                                                            
 [5136] "Intracranial_Chondrosarcoma"                                                                                                                                          
 [5137] "Central_Nervous_System_Rhabdomyosarcoma"                                                                                                                              
 [5138] "Central_Nervous_System_Fibrosarcoma"                                                                                                                                  
 [5139] "Central_Nervous_System_Paraganglioma"                                                                                                                                 
 [5140] "Stage_IA_Gastric_Cancer"                                                                                                                                              
 [5141] "Stage_IB_Gastric_Cancer"                                                                                                                                              
 [5142] "Stage_IIIB_Gastric_Cancer"                                                                                                                                            
 [5143] "Stage_IIIA_Gastric_Cancer"                                                                                                                                            
 [5144] "Gastric_Papillary_Adenocarcinoma"                                                                                                                                     
 [5145] "Gastric_Tubular_Adenocarcinoma"                                                                                                                                       
 [5146] "Gastric_Adenosquamous_Carcinoma"                                                                                                                                      
 [5147] "Gastric_Squamous_Cell_Carcinoma"                                                                                                                                      
 [5148] "Undifferentiated_Gastric_Carcinoma"                                                                                                                                   
 [5149] "Adult_Intracranial_Neoplasm"                                                                                                                                          
 [5150] "Cauda_Equina_Neoplasm"                                                                                                                                                
 [5151] "Gastric_Hemangioma"                                                                                                                                                   
 [5152] "Gastric_Lymphangioma"                                                                                                                                                 
 [5153] "Benign_Gastric_Granular_Cell_Tumor"                                                                                                                                   
 [5154] "Malignant_Gastric_Granular_Cell_Tumor"                                                                                                                                
 [5155] "Malignant_Gastric_Germ_Cell_Neoplasm"                                                                                                                                 
 [5156] "Gastric_Mesenchymal_Neoplasm"                                                                                                                                         
 [5157] "Gastric_Liposarcoma"                                                                                                                                                  
 [5158] "Gastric_Xanthoma"                                                                                                                                                     
 [5159] "Colon_Squamous_Cell_Carcinoma"                                                                                                                                        
 [5160] "Colon_Adenosquamous_Carcinoma"                                                                                                                                        
 [5161] "Colon_Leiomyoma"                                                                                                                                                      
 [5162] "Colon_Lipoma"                                                                                                                                                         
 [5163] "Colon_Leiomyosarcoma"                                                                                                                                                 
 [5164] "Colon_Sarcoma"                                                                                                                                                        
 [5165] "Colon_Tubulovillous_Adenoma"                                                                                                                                          
 [5166] "Colon_Carcinoid_Tumor"                                                                                                                                                
 [5167] "Colon_Mucosa-Associated_Lymphoid_Tissue_Lymphoma"                                                                                                                     
 [5168] "Colon_Hodgkin_s_Lymphoma"                                                                                                                                             
 [5169] "Colon_Lymphangioma"                                                                                                                                                   
 [5170] "Cecum_Carcinoid_Tumor"                                                                                                                                                
 [5171] "Benign_Peripheral_Nerve_Granular_Cell_Tumor"                                                                                                                          
 [5172] "Central_Nervous_System_Hematopoietic_Neoplasm"                                                                                                                        
 [5173] "Central_Nervous_System_Melanocytic_Neoplasm"                                                                                                                          
 [5174] "Central_Nervous_System_Melanoma"                                                                                                                                      
 [5175] "Endodermal_Cyst"                                                                                                                                                      
 [5176] "Central_Nervous_System_Epidermoid_Cyst"                                                                                                                               
 [5177] "Central_Nervous_System_Dermoid_Cyst"                                                                                                                                  
 [5178] "Central_Nervous_System_Hamartoma"                                                                                                                                     
 [5179] "Benign_Mucinous_Appendix_Cystadenoma"                                                                                                                                 
 [5180] "Appendix_Mucinous_Cystadenocarcinoma"                                                                                                                                 
 [5181] "Appendix_Villous_Adenoma"                                                                                                                                             
 [5182] "Appendix_Lymphoma"                                                                                                                                                    
 [5183] "Appendix_Leiomyoma"                                                                                                                                                   
 [5184] "Cecum_Lymphoma"                                                                                                                                                       
 [5185] "Colon_Kaposi_s_Sarcoma"                                                                                                                                               
 [5186] "Colon_Inflammatory_Polyp"                                                                                                                                             
 [5187] "Colon_Juvenile_Polyp"                                                                                                                                                 
 [5188] "Colon_Hamartomatous_Polyp"                                                                                                                                            
 [5189] "Cecum_Villous_Adenoma"                                                                                                                                                
 [5190] "Cecum_Non-Hodgkin_s_Lymphoma"                                                                                                                                         
 [5191] "Prostate_Rhabdomyosarcoma"                                                                                                                                            
 [5192] "Prostate_Kaposi_s_Sarcoma"                                                                                                                                            
 [5193] "Prostate_Stromal_Sarcoma"                                                                                                                                             
 [5194] "Prostate_Embryonal_Rhabdomyosarcoma"                                                                                                                                  
 [5195] "Prostate_Leiomyosarcoma"                                                                                                                                              
 [5196] "Prostate_Myeloid_Sarcoma"                                                                                                                                             
 [5197] "Prostate_Angiosarcoma"                                                                                                                                                
 [5198] "Gastric_Kaposi_s_Sarcoma"                                                                                                                                             
 [5199] "Prostate_Sarcomatoid_Carcinoma"                                                                                                                                       
 [5200] "Malignant_Prostate_Phyllodes_Tumor"                                                                                                                                   
 [5201] "Benign_Prostate_Phyllodes_Tumor"                                                                                                                                      
 [5202] "Prostate_Lymphoma"                                                                                                                                                    
 [5203] "Prostate_Non-Hodgkin_s_Lymphoma"                                                                                                                                      
 [5204] "Prostate_Signet_Ring_Cell_Carcinoma"                                                                                                                                  
 [5205] "Prostate_Squamous_Cell_Carcinoma"                                                                                                                                     
 [5206] "Prostate_Mucinous_Adenocarcinoma"                                                                                                                                     
 [5207] "Prostate_Adenosquamous_Carcinoma"                                                                                                                                     
 [5208] "Prostate_Adenoid_Cystic_Carcinoma"                                                                                                                                    
 [5209] "Prostate_Transitional_Cell_Carcinoma"                                                                                                                                 
 [5210] "High-Grade_Prostatic_Intraepithelial_Neoplasia"                                                                                                                       
 [5211] "Low-Grade_Prostatic_Intraepithelial_Neoplasia"                                                                                                                        
 [5212] "Cecum_Adenocarcinoma"                                                                                                                                                 
 [5213] "Prostate_Leiomyoma"                                                                                                                                                   
 [5214] "Prostate_Neuroendocrine_Neoplasm"                                                                                                                                     
 [5215] "Rectal_Adenoma"                                                                                                                                                       
 [5216] "Rectal_Carcinoid_Tumor"                                                                                                                                               
 [5217] "Rectal_Sarcoma"                                                                                                                                                       
 [5218] "Rectal_Leiomyosarcoma"                                                                                                                                                
 [5219] "Rectal_Kaposi_s_Sarcoma"                                                                                                                                              
 [5220] "Rectal_Lipoma"                                                                                                                                                        
 [5221] "Rectal_Leiomyoma"                                                                                                                                                     
 [5222] "Rectal_Lymphoma"                                                                                                                                                      
 [5223] "Rectal_Squamous_Cell_Carcinoma"                                                                                                                                       
 [5224] "Cloacogenic_Carcinoma_of_the_Rectum"                                                                                                                                  
 [5225] "Rectal_Sarcomatoid_Carcinoma"                                                                                                                                         
 [5226] "Ceruminous_Neoplasm"                                                                                                                                                  
 [5227] "Malignant_Eccrine_Neoplasm"                                                                                                                                           
 [5228] "Eccrine_Porocarcinoma"                                                                                                                                                
 [5229] "Skin_Appendage_Hamartoma"                                                                                                                                             
 [5230] "Apocrine_Sweat_Gland_Hamartoma"                                                                                                                                       
 [5231] "Eccrine_Sweat_Gland_Hamartoma"                                                                                                                                        
 [5232] "Pilosebaceous_Hamartoma"                                                                                                                                              
 [5233] "Cutaneous_Lipomatous_Neoplasm"                                                                                                                                        
 [5234] "Temporal_Lobe_Neoplasm"                                                                                                                                               
 [5235] "Nodulo-Ulcerative_Basal_Cell_Carcinoma"                                                                                                                               
 [5236] "Benign_Dermal_Schwannoma"                                                                                                                                             
 [5237] "Congenital_Skin_Nevus"                                                                                                                                                
 [5238] "Adnexal_Adenocarcinoma"                                                                                                                                               
 [5239] "Frontal_Lobe_Neoplasm"                                                                                                                                                
 [5240] "Parietal_Lobe_Neoplasm"                                                                                                                                               
 [5241] "Occipital_Lobe_Neoplasm"                                                                                                                                              
 [5242] "Apocrine_Gland_Carcinoma"                                                                                                                                             
 [5243] "Malignant_Fibrous_Histiocytoma_of_the_Skin"                                                                                                                           
 [5244] "Stage_I_Uveal_Melanoma"                                                                                                                                               
 [5245] "Stage_II_Uveal_Melanoma"                                                                                                                                              
 [5246] "Stage_III_Uveal_Melanoma"                                                                                                                                             
 [5247] "Stage_IV_Uveal_Melanoma"                                                                                                                                              
 [5248] "Stage_I_Skin_Cancer"                                                                                                                                                  
 [5249] "Stage_II_Skin_Cancer"                                                                                                                                                 
 [5250] "Stage_III_Skin_Cancer"                                                                                                                                                
 [5251] "Stage_IV_Skin_Caner"                                                                                                                                                  
 [5252] "Skin_Sarcoma"                                                                                                                                                         
 [5253] "Middle_Cranial_Fossa_Meningioma"                                                                                                                                      
 [5254] "Visual_Pathway_Meningioma"                                                                                                                                            
 [5255] "Recurrent_Medulloblastoma"                                                                                                                                            
 [5256] "Jugular_Foramen_Neoplasm"                                                                                                                                             
 [5257] "Intraspinal_Cyst"                                                                                                                                                     
 [5258] "Benign_Childhood_Central_Nervous_System_Neoplasm"                                                                                                                     
 [5259] "Chordoid_Glioma"                                                                                                                                                      
 [5260] "Prostatic_Basal_Cell_Hyperplasia"                                                                                                                                     
 [5261] "Prostatic_Cribriform_Hyperplasia"                                                                                                                                     
 [5262] "Prostatic_Atypical_Adenomatous_Hyperplasia"                                                                                                                           
 [5263] "Acinar_Prostate_Adenocarcinoma"                                                                                                                                       
 [5264] "Undifferentiated_Prostate_Carcinoma"                                                                                                                                  
 [5265] "Anal_Paget_s_Disease"                                                                                                                                                 
 [5266] "Anal_Leiomyosarcoma"                                                                                                                                                  
 [5267] "Anal_Adenocarcinoma"                                                                                                                                                  
 [5268] "Anal_Lymphoma"                                                                                                                                                        
 [5269] "Anal_Kaposi_s_Sarcoma"                                                                                                                                                
 [5270] "Anal_Neuroendocrine_Neoplasm"                                                                                                                                         
 [5271] "Anal_Fibroepithelial_Polyp"                                                                                                                                           
 [5272] "Anal_Mucinous_Adenocarcinoma"                                                                                                                                         
 [5273] "Benign_Anal_Granular_Cell_Tumor"                                                                                                                                      
 [5274] "Anal_Leiomyoma"                                                                                                                                                       
 [5275] "Anal_Glands_Adenocarcinoma"                                                                                                                                           
 [5276] "Anal_Rhabdomyosarcoma"                                                                                                                                                
 [5277] "Anal_Sarcoma"                                                                                                                                                         
 [5278] "Metastatic_Anal_Carcinoma"                                                                                                                                            
 [5279] "Benign_Eccrine_Spiradenoma"                                                                                                                                           
 [5280] "Malignant_Cutaneous_Granular_Cell_Tumor"                                                                                                                              
 [5281] "Cutaneous_Liposarcoma"                                                                                                                                                
 [5282] "Solid_Nodular_Basal_Cell_Skin_Carcinoma"                                                                                                                              
 [5283] "Cutaneous_Granular_Cell_Tumor"                                                                                                                                        
 [5284] "Rectal_Juvenile_Polyp"                                                                                                                                                
 [5285] "Rectal_Hyperplastic_Polyp"                                                                                                                                            
 [5286] "Rectal_Tubulovillous_Adenoma"                                                                                                                                         
 [5287] "Rectal_Adenoma_with_Severe_Dysplasia"                                                                                                                                 
 [5288] "Adult_Acute_Lymphoblastic_Leukemia_in_Complete_Remission"                                                                                                             
 [5289] "Adult_Acute_Lymphoblastic_Leukemia_in_Partial_Remission"                                                                                                              
 [5290] "V-SRC_Gene"                                                                                                                                                           
 [5291] "Rectal_Rhabdomyosarcoma"                                                                                                                                              
 [5292] "Metastatic_Skin_Cancer"                                                                                                                                               
 [5293] "Metastasis_to_Skin"                                                                                                                                                   
 [5294] "Aleukemic_Monocytic_Leukemia_Cutis"                                                                                                                                   
 [5295] "Aleukemic_Lymphoblastic_Leukemia_Cutis"                                                                                                                               
 [5296] "Stage_IB_Hodgkin_s_Lymphoma"                                                                                                                                          
 [5297] "Stage_IVB_Hodgkin_s_Lymphoma"                                                                                                                                         
 [5298] "Stage_I_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma"                                                                                                            
 [5299] "Small_Intestinal_Mucosa-Associated_Lymphoid_Tissue_Lymphoma"                                                                                                          
 [5300] "Childhood_Anaplastic_Large_Cell_Lymphoma"                                                                                                                             
 [5301] "Childhood_Mature_T-and_NK-Cell_Lymphoma"                                                                                                                              
 [5302] "Gastric_Hodgkin_s_Lymphoma"                                                                                                                                           
 [5303] "Childhood_Precursor_T-Lymphoblastic_Lymphoma_Leukemia"                                                                                                                
 [5304] "Occult_Lung_Carcinoma"                                                                                                                                                
 [5305] "Stage_IA_Lung_Carcinoma"                                                                                                                                              
 [5306] "Stage_IB_Lung_Carcinoma"                                                                                                                                              
 [5307] "Stage_IIA_Lung_Carcinoma"                                                                                                                                             
 [5308] "Stage_IIB_Lung_Carcinoma"                                                                                                                                             
 [5309] "Stage_IIIA_Lung_Carcinoma"                                                                                                                                            
 [5310] "Stage_IIIB_Lung_Carcinoma"                                                                                                                                            
 [5311] "Acinar_Lung_Adenocarcinoma"                                                                                                                                           
 [5312] "Papillary_Lung_Adenocarcinoma"                                                                                                                                        
 [5313] "Solid_Lung_Carcinoma_with_Mucus_Formation"                                                                                                                            
 [5314] "Stage_IA_Non-Small_Cell_Lung_Carcinoma"                                                                                                                               
 [5315] "Stage_IB_Non-Small_Cell_Lung_Carcinoma"                                                                                                                               
 [5316] "Stage_IIB_Non-Small_Cell_Lung_Carcinoma"                                                                                                                              
 [5317] "Stage_IIA_Non-Small_Cell_Lung_Carcinoma"                                                                                                                              
 [5318] "Lung_Sclerosing_Hemangioma"                                                                                                                                           
 [5319] "Lung_Myolipoma"                                                                                                                                                       
 [5320] "Lung_Fibroma"                                                                                                                                                         
 [5321] "Lung_Chondroid_Hamartoma"                                                                                                                                             
 [5322] "Lung_Leiomyoma"                                                                                                                                                       
 [5323] "Endobronchial_Leiomyoma"                                                                                                                                              
 [5324] "Endobronchial_Hamartoma"                                                                                                                                              
 [5325] "Multiple_Chondromatous_Lung_Hamartoma"                                                                                                                                
 [5326] "Bronchial_Mucus_Gland_Adenoma"                                                                                                                                        
 [5327] "Atypical_Adenomatous_Lung_Hyperplasia"                                                                                                                                
 [5328] "Lung_Adenoid_Cystic_Carcinoma"                                                                                                                                        
 [5329] "Lung_Leiomyosarcoma"                                                                                                                                                  
 [5330] "Lung_Meningioma"                                                                                                                                                      
 [5331] "Pleuropulmonary_Blastoma"                                                                                                                                             
 [5332] "Lung_Neuroendocrine_Neoplasm"                                                                                                                                         
 [5333] "Lung_Hilum_Neoplasm"                                                                                                                                                  
 [5334] "Large_Cell_Neuroendocrine_Lung_Carcinoma"                                                                                                                             
 [5335] "Colorectal_Adenoma"                                                                                                                                                   
 [5336] "Colorectal_Serrated_Adenoma"                                                                                                                                          
 [5337] "Colorectal_Tubulovillous_Adenoma"                                                                                                                                     
 [5338] "Colorectal_Villous_Adenoma"                                                                                                                                           
 [5339] "Colorectal_Leiomyoma"                                                                                                                                                 
 [5340] "Colorectal_Lipoma"                                                                                                                                                    
 [5341] "Colorectal_Polyp"                                                                                                                                                     
 [5342] "Colorectal_Inflammatory_Polyp"                                                                                                                                        
 [5343] "Colorectal_Juvenile_Polyp"                                                                                                                                            
 [5344] "Colorectal_Hyperplastic_Polyp"                                                                                                                                        
 [5345] "Lung_Non-Hodgkin_s_Lymphoma"                                                                                                                                          
 [5346] "Colorectal_Adenoma_with_Severe_Dysplasia"                                                                                                                             
 [5347] "Peutz-Jeghers_Colon_Polyp"                                                                                                                                            
 [5348] "Esophageal_Lymphoma"                                                                                                                                                  
 [5349] "Esophageal_Non-Hodgkin_s_Lymphoma"                                                                                                                                    
 [5350] "Esophageal_Hodgkin_s_Lymphoma"                                                                                                                                        
 [5351] "Stage_IIA_Esophageal_Cancer"                                                                                                                                          
 [5352] "Stage_IIB_Esophageal_Cancer"                                                                                                                                          
 [5353] "Stage_IVB_Esophageal_Cancer"                                                                                                                                          
 [5354] "Stage_IVA_Esophageal_Cancer"                                                                                                                                          
 [5355] "Intestinal_Neuroendocrine_Neoplasm"                                                                                                                                   
 [5356] "Gastric_Neuroendocrine_Neoplasm"                                                                                                                                      
 [5357] "Colon_Neuroendocrine_Neoplasm"                                                                                                                                        
 [5358] "Rectal_Neuroendocrine_Neoplasm"                                                                                                                                       
 [5359] "Giant_Fibrovascular_Esophageal_Polyp"                                                                                                                                 
 [5360] "Esophageal_Granular_Cell_Tumor"                                                                                                                                       
 [5361] "Esophageal_Lipoma"                                                                                                                                                    
 [5362] "Esophageal_Fibroma"                                                                                                                                                   
 [5363] "Benign_Esophageal_Schwannoma"                                                                                                                                         
 [5364] "Esophageal_Neurofibroma"                                                                                                                                              
 [5365] "Esophageal_Liposarcoma"                                                                                                                                               
 [5366] "Esophageal_Kaposi_s_Sarcoma"                                                                                                                                          
 [5367] "Esophageal_Melanoma"                                                                                                                                                  
 [5368] "Stage_III_Childhood_Hepatocellular_Carcinoma"                                                                                                                         
 [5369] "Stage_II_Childhood_Hepatocellular_Carcinoma"                                                                                                                          
 [5370] "Stage_I_Childhood_Hepatocellular_Carcinoma"                                                                                                                           
 [5371] "Stage_IV_Pancreatic_Cancer"                                                                                                                                           
 [5372] "Pancreatic_Serous_Cystadenoma"                                                                                                                                        
 [5373] "Pancreatic_Mucinous_Cystadenocarcinoma"                                                                                                                               
 [5374] "Pancreatic_Lymphoma"                                                                                                                                                  
 [5375] "Pancreatic_Sarcoma"                                                                                                                                                   
 [5376] "Borderline_Exocrine_Pancreatic_Neoplasm"                                                                                                                              
 [5377] "Pancreatic_Mucinous_Ductal_Ectasia"                                                                                                                                   
 [5378] "Pancreatic_Mucinous_Cystadenoma"                                                                                                                                      
 [5379] "Pancreatic_Intraductal_Papillary-Mucinous_Neoplasm_with_Moderate_Dysplasia"                                                                                           
 [5380] "Pancreatic_Signet_Ring_Cell_Carcinoma"                                                                                                                                
 [5381] "Pancreatic_Adenosquamous_Carcinoma"                                                                                                                                   
 [5382] "Undifferentiated_Pancreatic_Carcinoma"                                                                                                                                
 [5383] "Pancreatic_Osteoclast-Like_Giant_Cell_Carcinoma"                                                                                                                      
 [5384] "Pancreatic_Serous_Cystadenocarcinoma"                                                                                                                                 
 [5385] "Pancreatic_Intraductal_Papillary-Mucinous_Carcinoma"                                                                                                                  
 [5386] "Pancreatic_Invasive_Papillary-Mucinous_Carcinoma"                                                                                                                     
 [5387] "Pancreatic_Acinar_Cell_Cystadenocarcinoma"                                                                                                                            
 [5388] "Solid_Pseudopapillary_Carcinoma_of_the_Pancreas"                                                                                                                      
 [5389] "Stage_0_Pancreatic_Cancer"                                                                                                                                            
 [5390] "Stage_IVA_Pancreatic_Cancer"                                                                                                                                          
 [5391] "Duodenal_G-Cell_Gastrin_Producing_Neoplasm"                                                                                                                           
 [5392] "Gallbladder_Lymphoma"                                                                                                                                                 
 [5393] "Gallbladder_Melanoma"                                                                                                                                                 
 [5394] "Gallbladder_Sarcoma"                                                                                                                                                  
 [5395] "Stage_I_Gallbladder_Cancer"                                                                                                                                           
 [5396] "Stage_II_Gallbladder_Cancer"                                                                                                                                          
 [5397] "Stage_III_Gallbladder_Cancer"                                                                                                                                         
 [5398] "Stage_IV_Gallbladder_Cancer"                                                                                                                                          
 [5399] "Stage_IVA_Gallbladder_Cancer"                                                                                                                                         
 [5400] "Stage_IVB_Gallbladder_Cancer"                                                                                                                                         
 [5401] "Gallbladder_Papillary_Carcinoma"                                                                                                                                      
 [5402] "Gallbladder_Mucinous_Carcinoma"                                                                                                                                       
 [5403] "Gallbladder_Signet_Ring_Cell_Carcinoma"                                                                                                                               
 [5404] "Gallbladder_Neurofibroma"                                                                                                                                             
 [5405] "Gallbladder_Leiomyoma"                                                                                                                                                
 [5406] "Benign_Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm"                                                                                                    
 [5407] "Hepatic_Lipoma"                                                                                                                                                       
 [5408] "Hepatic_Mesenchymal_Hamartoma"                                                                                                                                        
 [5409] "Hepatic_Fibroma"                                                                                                                                                      
 [5410] "Hepatic_Leiomyoma"                                                                                                                                                    
 [5411] "Clear_Cell_Hepatocellular_Carcinoma"                                                                                                                                  
 [5412] "Hepatic_Leiomyosarcoma"                                                                                                                                               
 [5413] "Stage_I_Hepatocellular_Carcinoma"                                                                                                                                     
 [5414] "Stage_II_Hepatocellular_Carcinoma"                                                                                                                                    
 [5415] "Stage_III_Hepatocellular_Carcinoma"                                                                                                                                   
 [5416] "Stage_IIIA_Hepatocellular_Carcinoma"                                                                                                                                  
 [5417] "Stage_IIIB_Hepatocellular_Carcinoma"                                                                                                                                  
 [5418] "Stage_IV_Hepatocellular_Carcinoma"                                                                                                                                    
 [5419] "Stage_IVA_Hepatocellular_Carcinoma"                                                                                                                                   
 [5420] "Stage_IVB_Hepatocellular_Carcinoma"                                                                                                                                   
 [5421] "Hepatic_Non-Hodgkin_s_Lymphoma"                                                                                                                                       
 [5422] "Hepatic_Mucosa-Associated_Lymphoid_Tissue_Lymphoma"                                                                                                                   
 [5423] "Stage_I_Extrahepatic_Bile_Duct_Cancer"                                                                                                                                
 [5424] "Stage_II_Extrahepatic_Bile_Duct_Cancer"                                                                                                                               
 [5425] "Stage_III_Extrahepatic_Bile_Duct_Cancer"                                                                                                                              
 [5426] "Stage_IV_Extrahepatic_Bile_Duct_Cancer"                                                                                                                               
 [5427] "Stage_IVA_Extrahepatic_Bile_Duct_Cancer"                                                                                                                              
 [5428] "Stage_IVB_Extrahepatic_Bile_Duct_Cancer"                                                                                                                              
 [5429] "Clear_Cell_Bile_Duct_Adenocarcinoma"                                                                                                                                  
 [5430] "Signet_Ring_Cell_Bile_Duct_Carcinoma"                                                                                                                                 
 [5431] "Squamous_Cell_Bile_Duct_Carcinoma"                                                                                                                                    
 [5432] "Adenosquamous_Bile_Duct_Carcinoma"                                                                                                                                    
 [5433] "Undifferentiated_Extrahepatic_Bile_Duct_Carcinoma"                                                                                                                    
 [5434] "Hepatic_Carcinoid_Tumor"                                                                                                                                              
 [5435] "Jejunal_Delta_Cell_Somatostatin_Producing_Neoplasm"                                                                                                                   
 [5436] "Pancreatic_Non-Hodgkin_s_Lymphoma"                                                                                                                                    
 [5437] "Adult_Central_Nervous_System_Embryonal_Carcinoma"                                                                                                                     
 [5438] "Adult_Central_Nervous_System_Germinoma"                                                                                                                               
 [5439] "Adult_Central_Nervous_System_Choriocarcinoma"                                                                                                                         
 [5440] "Adult_Central_Nervous_System_Teratoma"                                                                                                                                
 [5441] "Childhood_Brain_Germ_Cell_Neoplasm"                                                                                                                                   
 [5442] "Benign_Adult_Cerebellar_Neoplasm"                                                                                                                                     
 [5443] "Benign_Adult_Brain_Stem_Neoplasm"                                                                                                                                     
 [5444] "Benign_Childhood_Brain_Neoplasm"                                                                                                                                      
 [5445] "Benign_Childhood_Supratentorial_Neoplasm"                                                                                                                             
 [5446] "Childhood_Choroid_Plexus_Papilloma"                                                                                                                                   
 [5447] "Childhood_Cerebral_Cyst"                                                                                                                                              
 [5448] "Childhood_Infratentorial_Neoplasm"                                                                                                                                    
 [5449] "Small_Intestinal_Neuroendocrine_Neoplasm"                                                                                                                             
 [5450] "Gastric_Gastrointestinal_Stromal_Tumor"                                                                                                                               
 [5451] "Stage_I_Small_Intestinal_Cancer"                                                                                                                                      
 [5452] "Stage_II_Small_Intestinal_Cancer"                                                                                                                                     
 [5453] "Stage_III_Small_Intestinal_Cancer"                                                                                                                                    
 [5454] "Stage_IV_Small_Intestinal_Cancer"                                                                                                                                     
 [5455] "Small_Intestinal_Gastrointestinal_Stromal_Tumor"                                                                                                                      
 [5456] "Adult_Third_Ventricle_Colloid_Cyst"                                                                                                                                   
 [5457] "Childhood_Third_Ventricle_Colloid_Cyst"                                                                                                                               
 [5458] "Metastatic_Neoplasm_to_the_Adult_Brain"                                                                                                                               
 [5459] "Intracranial_Primitive_Neuroectodermal_Neoplasm"                                                                                                                      
 [5460] "Pharyngeal_Adenoid_Cystic_Carcinoma"                                                                                                                                  
 [5461] "Buccal_Mucosa_Papilloma"                                                                                                                                              
 [5462] "Esophageal_Carcinoid_Tumor"                                                                                                                                           
 [5463] "Esophageal_Neuroendocrine_Neoplasm"                                                                                                                                   
 [5464] "Nerve_Plexus_Neoplasm"                                                                                                                                                
 [5465] "Brachial_Plexus_Neoplasm"                                                                                                                                             
 [5466] "Lumbar_Plexus_Neoplasm"                                                                                                                                               
 [5467] "Trochlear_Nerve_Neoplasm"                                                                                                                                             
 [5468] "Abducens_Nerve_Neoplasm"                                                                                                                                              
 [5469] "Facial_Nerve_Neoplasm"                                                                                                                                                
 [5470] "Glossopharyngeal_Nerve_Neoplasm"                                                                                                                                      
 [5471] "Spinal_Accessory_Nerve_Neoplasm"                                                                                                                                      
 [5472] "Hypoglossal_Nerve_Neoplasm"                                                                                                                                           
 [5473] "Vagus_Nerve_Neoplasm"                                                                                                                                                 
 [5474] "Hepatic_Fibrosarcoma"                                                                                                                                                 
 [5475] "Hepatic_Osteosarcoma"                                                                                                                                                 
 [5476] "Hepatic_Rhabdomyosarcoma"                                                                                                                                             
 [5477] "Gallbladder_Lipoma"                                                                                                                                                   
 [5478] "Gallbladder_Pleomorphic_Giant_Cell_Adenocarcinoma"                                                                                                                    
 [5479] "Gallbladder_Rhabdomyosarcoma"                                                                                                                                         
 [5480] "Gallbladder_Angiosarcoma"                                                                                                                                             
 [5481] "Gallbladder_Leiomyosarcoma"                                                                                                                                           
 [5482] "Gallbladder_Kaposi_s_Sarcoma"                                                                                                                                         
 [5483] "Small_Cell_Extrahepatic_Bile_Duct_Carcinoma"                                                                                                                          
 [5484] "Mucinous_Bile_Duct_Adenocarcinoma"                                                                                                                                    
 [5485] "Extrahepatic_Bile_Duct_Embryonal_Rhabdomyosarcoma"                                                                                                                    
 [5486] "Extrahepatic_Bile_Duct_Leiomyosarcoma"                                                                                                                                
 [5487] "Extrahepatic_Bile_Duct_Papillary_Adenoma"                                                                                                                             
 [5488] "Extrahepatic_Bile_Duct_Tubular_Adenoma"                                                                                                                               
 [5489] "Extrahepatic_Bile_Duct_Cystadenoma"                                                                                                                                   
 [5490] "Benign_Granular_Cell_Tumor_of_Extrahepatic_Bile_Ducts"                                                                                                                
 [5491] "Extrahepatic_Bile_Duct_Fibroma"                                                                                                                                       
 [5492] "Extrahepatic_Bile_Duct_Lipoma"                                                                                                                                        
 [5493] "Extrahepatic_Bile_Duct_Leiomyoma"                                                                                                                                     
 [5494] "Benign_Extrahepatic_Bile_Duct_Mesenchymal_Neoplasm"                                                                                                                   
 [5495] "Extrahepatic_Bile_Duct_Adenoma"                                                                                                                                       
 [5496] "Hepatic_Inflammatory_Pseudotumor"                                                                                                                                     
 [5497] "Perihilar_Extrahepatic_Bile_Duct_Carcinoma"                                                                                                                           
 [5498] "Bile_Duct_Rhabdomyosarcoma"                                                                                                                                           
 [5499] "Extrahepatic_Bile_Duct_Carcinoid_Tumor"                                                                                                                               
 [5500] "Bile_Duct_Mucoepidermoid_Carcinoma"                                                                                                                                   
 [5501] "Stage_IVA_Oral_Cavity_Adenoid_Cystic_Carcinoma"                                                                                                                       
 [5502] "Stage_IVB_Oral_Cavity_Adenoid_Cystic_Carcinoma"                                                                                                                       
 [5503] "Stage_IVC_Oral_Cavity_Adenoid_Cystic_Carcinoma"                                                                                                                       
 [5504] "Stage_IVC_Oral_Cavity_Mucoepidermoid_Carcinoma"                                                                                                                       
 [5505] "Stage_IVB_Oral_Cavity_Mucoepidermoid_Carcinoma"                                                                                                                       
 [5506] "Stage_IVA_Oral_Cavity_Mucoepidermoid_Carcinoma"                                                                                                                       
 [5507] "Stage_IVA_Oral_Cavity_Verrucous_Carcinoma"                                                                                                                            
 [5508] "Stage_IVB_Oral_Cavity_Verrucous_Carcinoma"                                                                                                                            
 [5509] "Stage_IVC_Oral_Cavity_Verrucous_Carcinoma"                                                                                                                            
 [5510] "Stage_IVC_Basal_Cell_Lip_Carcinoma"                                                                                                                                   
 [5511] "Stage_IVB_Basal_Cell_Lip_Carcinoma"                                                                                                                                   
 [5512] "Stage_IVA_Basal_Cell_Lip_Carcinoma"                                                                                                                                   
 [5513] "Stage_I_Lip_Cancer"                                                                                                                                                   
 [5514] "Stage_II_Lip_Cancer"                                                                                                                                                  
 [5515] "Stage_III_Lip_Cancer"                                                                                                                                                 
 [5516] "Stage_IV_Lip_Cancer"                                                                                                                                                  
 [5517] "Stage_IVA_Lip_Carcinoma"                                                                                                                                              
 [5518] "Stage_IVB_Lip_Carcinoma"                                                                                                                                              
 [5519] "Stage_IVC_Lip_Carcinoma"                                                                                                                                              
 [5520] "Stage_I_Oral_Cavity_Carcinoma"                                                                                                                                        
 [5521] "Stage_II_Oral_Cavity_Carcinoma"                                                                                                                                       
 [5522] "Stage_III_Oral_Cavity_Carcinoma"                                                                                                                                      
 [5523] "Stage_IV_Oral_Cavity_Carcinoma"                                                                                                                                       
 [5524] "Stage_IVA_Oral_Cavity_Carcinoma"                                                                                                                                      
 [5525] "Stage_IVB_Oral_Cavity_Carcinoma"                                                                                                                                      
 [5526] "Stage_IVC_Oral_Cavity_Carcinoma"                                                                                                                                      
 [5527] "Stage_0_Oral_Cavity_Verrucous_Carcinoma"                                                                                                                              
 [5528] "Stage_0_Lip_Basal_Cell_Carcinoma"                                                                                                                                     
 [5529] "Stage_I_Major_Salivary_Gland_Carcinoma"                                                                                                                               
 [5530] "Stage_II_Major_Salivary_Gland_Carcinoma"                                                                                                                              
 [5531] "Stage_III_Major_Salivary_Gland_Carcinoma"                                                                                                                             
 [5532] "Stage_IV_Major_Salivary_Gland_Carcinoma"                                                                                                                              
 [5533] "Stage_IV_Major_Salivary_Gland_Carcinoma_with_Metastasis"                                                                                                              
 [5534] "Stage_IV_Major_Salivary_Gland_Carcinoma_without_Metastasis"                                                                                                           
 [5535] "Major_Salivary_Gland_Acinic_Cell_Carcinoma"                                                                                                                           
 [5536] "Malignant_Mixed_Tumor_of_the_Major_Salivary_Gland"                                                                                                                    
 [5537] "Major_Salivary_Gland_Adenocarcinoma"                                                                                                                                  
 [5538] "Salivary_Duct_Carcinoma"                                                                                                                                              
 [5539] "Major_Salivary_Gland_Adenoid_Cystic_Carcinoma"                                                                                                                        
 [5540] "Major_Salivary_Gland_Mucoepidermoid_Carcinoma"                                                                                                                        
 [5541] "Major_Salivary_Gland_Carcinoma"                                                                                                                                       
 [5542] "Salivary_Gland_Mucoepidermoid_Carcinoma"                                                                                                                              
 [5543] "Oral_Cavity_Leiomyoma"                                                                                                                                                
 [5544] "Oral_Cavity_Lipoma"                                                                                                                                                   
 [5545] "Oral_Cavity_Granular_Cell_Tumor"                                                                                                                                      
 [5546] "Oral_Cavity_Adenoma"                                                                                                                                                  
 [5547] "Oral_Cavity_Adenocarcinoma"                                                                                                                                           
 [5548] "Oral_Cavity_Mucosal_Melanoma"                                                                                                                                         
 [5549] "Oral_Cavity_Sarcoma"                                                                                                                                                  
 [5550] "Upper_Gingival_Verrucous_Carcinoma"                                                                                                                                   
 [5551] "Tonsillar_Lymphoma"                                                                                                                                                   
 [5552] "Astler-Coller_B3_Colon_Carcinoma"                                                                                                                                     
 [5553] "Astler-Coller_B3_Rectal_Carcinoma"                                                                                                                                    
 [5554] "Astler-Coller_C3_Rectal_Carcinoma"                                                                                                                                    
 [5555] "Astler-Coller_C1_Rectal_Carcinoma"                                                                                                                                    
 [5556] "Astler-Coller_C2_Rectal_Carcinoma"                                                                                                                                    
 [5557] "Astler-Coller_A_Rectal_Carcinoma"                                                                                                                                     
 [5558] "Stage_IIIA_Anal_Cancer"                                                                                                                                               
 [5559] "Stage_IIIB_Anal_Cancer"                                                                                                                                               
 [5560] "Astler-Coller_A_Colorectal_Carcinoma"                                                                                                                                 
 [5561] "Astler-Coller_B3_Colorectal_Carcinoma"                                                                                                                                
 [5562] "Astler-Coller_C3_Colorectal_Carcinoma"                                                                                                                                
 [5563] "Astler-Coller_C2_Colorectal_Carcinoma"                                                                                                                                
 [5564] "Astler-Coller_C1_Colorectal_Carcinoma"                                                                                                                                
 [5565] "Salivary_Gland_Oncocytoma"                                                                                                                                            
 [5566] "Parotid_Gland_Acinic_Cell_Carcinoma"                                                                                                                                  
 [5567] "Submandibular_Gland_Acinic_Cell_Carcinoma"                                                                                                                            
 [5568] "Submandibular_Gland_Adenoid_Cystic_Carcinoma"                                                                                                                         
 [5569] "Minor_Salivary_Gland_Adenoid_Cystic_Carcinoma"                                                                                                                        
 [5570] "Parotid_Gland_Adenoid_Cystic_Carcinoma"                                                                                                                               
 [5571] "Parotid_Gland_Mucoepidermoid_Carcinoma"                                                                                                                               
 [5572] "Submandibular_Gland_Mucoepidermoid_Carcinoma"                                                                                                                         
 [5573] "Submandibular_Gland_Adenocarcinoma"                                                                                                                                   
 [5574] "Parotid_Gland_Adenocarcinoma"                                                                                                                                         
 [5575] "Parotid_Gland_Squamous_Cell_Carcinoma"                                                                                                                                
 [5576] "Submandibular_Gland_Squamous_Cell_Carcinoma"                                                                                                                          
 [5577] "Malignant_Submandibular_Gland_Mixed_Tumor"                                                                                                                            
 [5578] "Malignant_Parotid_Gland_Mixed_Tumor"                                                                                                                                  
 [5579] "Undifferentiated_Parotid_Gland_Carcinoma"                                                                                                                             
 [5580] "Submandibular_Gland_Undifferentiated_Carcinoma"                                                                                                                       
 [5581] "Minor_Salivary_Gland_Adenocarcinoma"                                                                                                                                  
 [5582] "Parotid_Gland_Sebaceous_Lymphadenoma"                                                                                                                                 
 [5583] "Salivary_Gland_Basal_Cell_Adenoma"                                                                                                                                    
 [5584] "Parotid_Gland_Non-Hodgkin_s_Lymphoma"                                                                                                                                 
 [5585] "Parotid_Gland_Kaposi_s_Sarcoma"                                                                                                                                       
 [5586] "Minor_Salivary_Gland_Mucoepidermoid_Carcinoma"                                                                                                                        
 [5587] "Minor_Salivary_Gland_Undifferentiated_Carcinoma"                                                                                                                      
 [5588] "Malignant_Mixed_Tumor_of_the_Minor_Salivary_Gland"                                                                                                                    
 [5589] "Minor_Salivary_Gland_Anaplastic_Small_Cell_Carcinoma"                                                                                                                 
 [5590] "Minor_Salivary_Gland_Carcinoma"                                                                                                                                       
 [5591] "Sublingual_Gland_Adenocarcinoma"                                                                                                                                      
 [5592] "Minor_Salivary_Gland_Squamous_Cell_Carcinoma"                                                                                                                         
 [5593] "Childhood_Supratentorial_Neoplasm"                                                                                                                                    
 [5594] "Childhood_Central_Nervous_System_Primitive_Neuroectodermal_Tumor"                                                                                                     
 [5595] "Malignant_Prolactin_Producing_Pituitary_Gland_Neoplasm"                                                                                                               
 [5596] "Malignant_Growth_Hormone_Secreting_Pituitary_Neoplasm"                                                                                                                
 [5597] "Malignant_ACTH_Producing_Pituitary_Gland_Neoplasm"                                                                                                                    
 [5598] "Malignant_Thyroid_Stimulating_Hormone_Producing_Pituitary_Gland_Neoplasm"                                                                                             
 [5599] "Anaplastic_Brain_Stem_Astrocytoma"                                                                                                                                    
 [5600] "Adult_Brain_Stem_Neoplasm"                                                                                                                                            
 [5601] "Adult_Cerebellar_Neoplasm"                                                                                                                                            
 [5602] "Childhood_Brain_Stem_Neoplasm"                                                                                                                                        
 [5603] "Childhood_Cerebellar_Neoplasm"                                                                                                                                        
 [5604] "Ear_Polyp"                                                                                                                                                            
 [5605] "Subglottic_Carcinoma"                                                                                                                                                 
 [5606] "Supraglottic_Carcinoma"                                                                                                                                               
 [5607] "Parotid_Gland_Carcinoma_Ex_Pleomorphic_Adenoma"                                                                                                                       
 [5608] "Major_Salivary_Gland_Carcinoma_Ex_Pleomorphic_Adenoma"                                                                                                                
 [5609] "Minor_Salivary_Gland_Carcinoma_Ex_Pleomorphic_Adenoma"                                                                                                                
 [5610] "Submandibular_Gland_Carcinoma_Ex_Pleomorphic_Adenoma"                                                                                                                 
 [5611] "Benign_Salivary_Gland_Myoepithelioma"                                                                                                                                 
 [5612] "Salivary_Gland_Canalicular_Adenoma"                                                                                                                                   
 [5613] "Salivary_Gland_Cystadenocarcinoma"                                                                                                                                    
 [5614] "Major_Salivary_Gland_Non-Hodgkin_s_Lymphoma"                                                                                                                          
 [5615] "Parotid_Gland_Lipoma"                                                                                                                                                 
 [5616] "Major_Salivary_Gland_Sarcoma"                                                                                                                                         
 [5617] "Stage_IVA_Oropharyngeal_Carcinoma"                                                                                                                                    
 [5618] "Stage_IVB_Oropharyngeal_Carcinoma"                                                                                                                                    
 [5619] "Stage_IVC_Oropharyngeal_Carcinoma"                                                                                                                                    
 [5620] "Oropharyngeal_Polyp"                                                                                                                                                  
 [5621] "Tonsillar_Lipoma"                                                                                                                                                     
 [5622] "Posterior_Tongue_Mucoepidermoid_Carcinoma"                                                                                                                            
 [5623] "Posterior_Tongue_Adenoid_Cystic_Carcinoma"                                                                                                                            
 [5624] "Stage_IVA_Hypopharyngeal_Carcinoma"                                                                                                                                   
 [5625] "Stage_IVB_Hypopharyngeal_Carcinoma"                                                                                                                                   
 [5626] "Stage_IVC_Hypopharyngeal_Carcinoma"                                                                                                                                   
 [5627] "Stage_IVC_Nasopharyngeal_Carcinoma"                                                                                                                                   
 [5628] "Stage_IVB_Nasopharyngeal_Carcinoma"                                                                                                                                   
 [5629] "Stage_IVA_Nasopharyngeal_Carcinoma"                                                                                                                                   
 [5630] "Stage_IIA_Nasopharyngeal_Carcinoma"                                                                                                                                   
 [5631] "Stage_IIB_Nasopharyngeal_Carcinoma"                                                                                                                                   
 [5632] "Stage_IVA_Pharyngeal_Cancer"                                                                                                                                          
 [5633] "Stage_IVB_Pharyngeal_Cancer"                                                                                                                                          
 [5634] "Stage_IVC_Pharyngeal_Cancer"                                                                                                                                          
 [5635] "Stage_IVC_Laryngeal_Cancer"                                                                                                                                           
 [5636] "Stage_IVB_Laryngeal_Cancer"                                                                                                                                           
 [5637] "Stage_IVA_Laryngeal_Cancer"                                                                                                                                           
 [5638] "Stage_I_Paranasal_Sinus_Cancer"                                                                                                                                       
 [5639] "Stage_II_Paranasal_Sinus_Cancer"                                                                                                                                      
 [5640] "Stage_III_Paranasal_Sinus_Cancer"                                                                                                                                     
 [5641] "Stage_IV_Paranasal_Sinus_Cancer"                                                                                                                                      
 [5642] "Stage_IV_Nasal_Cavity_Carcinoma"                                                                                                                                      
 [5643] "Stage_III_Nasal_Cavity_Carcinoma"                                                                                                                                     
 [5644] "Stage_II_Nasal_Cavity_Carcinoma"                                                                                                                                      
 [5645] "Stage_I_Nasal_Cavity_Carcinoma"                                                                                                                                       
 [5646] "Paranasal_Sinus_Carcinoma"                                                                                                                                            
 [5647] "Nasal_Cavity_Adenocarcinoma"                                                                                                                                          
 [5648] "Paranasal_Sinus_Olfactory_Neuroblastoma"                                                                                                                              
 [5649] "Paranasal_Sinus_Adenocarcinoma"                                                                                                                                       
 [5650] "Paranasal_Sinus_Mucoepidermoid_Carcinoma"                                                                                                                             
 [5651] "Paranasal_Sinus_Adenoid_Cystic_Carcinoma"                                                                                                                             
 [5652] "Laryngeal_Sarcoma"                                                                                                                                                    
 [5653] "Laryngeal_Liposarcoma"                                                                                                                                                
 [5654] "Laryngeal_Leiomyosarcoma"                                                                                                                                             
 [5655] "Laryngeal_Neuroendocrine_Neoplasm"                                                                                                                                    
 [5656] "Laryngeal_Carcinoid_Tumor"                                                                                                                                            
 [5657] "Laryngeal_Small_Cell_Carcinoma"                                                                                                                                       
 [5658] "Subglottic_Hemangioma"                                                                                                                                                
 [5659] "Laryngeal_Leiomyoma"                                                                                                                                                  
 [5660] "Metastatic_Neoplasm_to_the_Hypopharynx"                                                                                                                               
 [5661] "Metastatic_Neoplasm_to_the_Oropharynx"                                                                                                                                
 [5662] "Metastatic_Neoplasm_to_the_Nasopharynx"                                                                                                                               
 [5663] "Metastatic_Neoplasm_to_the_Larynx"                                                                                                                                    
 [5664] "Parathyroid_Chief_Cell_Hyperplasia"                                                                                                                                   
 [5665] "Parathyroid_Clear_Cell_Hyperplasia"                                                                                                                                   
 [5666] "Nasopharyngeal_Polyp"                                                                                                                                                 
 [5667] "Stage_0_Nasopharyngeal_Undifferentiated_Carcinoma"                                                                                                                    
 [5668] "Stage_0_Nasopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                       
 [5669] "Squamous_Papilloma_of_the_Nasopharynx"                                                                                                                                
 [5670] "Oropharyngeal_Squamous_Papilloma"                                                                                                                                     
 [5671] "Stage_0_Oropharyngeal_Squamous_Cell_Carcinoma"                                                                                                                        
 [5672] "Poorly_Differentiated_Thyroid_Carcinoma"                                                                                                                              
 [5673] "Thyroid_Sarcoma"                                                                                                                                                      
 [5674] "Thyroid_Hurthle_Cell_Adenoma"                                                                                                                                         
 [5675] "Thyroid_Angiosarcoma"                                                                                                                                                 
 [5676] "Thyroid_Non-Hodgkin_s_Lymphoma"                                                                                                                                       
 [5677] "Thyroid_Diffuse_Large_B-Cell_Lymphoma"                                                                                                                                
 [5678] "Stage_0_Hypopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                       
 [5679] "Tracheal_Leiomyoma"                                                                                                                                                   
 [5680] "Tracheal_Sarcoma"                                                                                                                                                     
 [5681] "Tracheal_Adenoid_Cystic_Carcinoma"                                                                                                                                    
 [5682] "Stage_0_Oral_Cavity_Squamous_Cell_Carcinoma"                                                                                                                          
 [5683] "Stage_I_Oral_Cavity_Squamous_Cell_Carcinoma"                                                                                                                          
 [5684] "Stage_II_Oral_Cavity_Squamous_Cell_Carcinoma"                                                                                                                         
 [5685] "Stage_III_Oral_Cavity_Squamous_Cell_Carcinoma"                                                                                                                        
 [5686] "Stage_IV_Oral_Cavity_Squamous_Cell_Carcinoma"                                                                                                                         
 [5687] "Stage_IVA_Oral_Cavity_Squamous_Cell_Carcinoma"                                                                                                                        
 [5688] "Stage_IVB_Oral_Cavity_Squamous_Cell_Carcinoma"                                                                                                                        
 [5689] "Stage_IVC_Oral_Cavity_Squamous_Cell_Carcinoma"                                                                                                                        
 [5690] "Recurrent_Oral_Cavity_Squamous_Cell_Carcinoma"                                                                                                                        
 [5691] "Malignant_Anterior_Tongue_Neoplasm"                                                                                                                                   
 [5692] "Anterior_Tongue_Neoplasm"                                                                                                                                             
 [5693] "Benign_Anterior_Tongue_Neoplasm"                                                                                                                                      
 [5694] "Maxillary_Sinus_Squamous_Cell_Carcinoma"                                                                                                                              
 [5695] "Ethmoid_Sinus_Squamous_Cell_Carcinoma"                                                                                                                                
 [5696] "Sphenoid_Sinus_Squamous_Cell_Carcinoma"                                                                                                                               
 [5697] "Frontal_Sinus_Squamous_Cell_Carcinoma"                                                                                                                                
 [5698] "Paranasal_Sinus_Lymphoma"                                                                                                                                             
 [5699] "Paranasal_Sinus_Non-Hodgkin_s_Lymphoma"                                                                                                                               
 [5700] "Stage_IVA_Paranasal_Sinus_Cancer"                                                                                                                                     
 [5701] "Stage_IVB_Paranasal_Sinus_Cancer"                                                                                                                                     
 [5702] "Stage_IVC_Paranasal_Sinus_Cancer"                                                                                                                                     
 [5703] "Paranasal_Sinus_Diffuse_Large_B-Cell_Lymphoma"                                                                                                                        
 [5704] "Nasal_Cavity_Lymphoma"                                                                                                                                                
 [5705] "Nasal_Cavity_Non-Hodgkin_s_Lymphoma"                                                                                                                                  
 [5706] "Recurrent_Oral_Cavity_Carcinoma"                                                                                                                                      
 [5707] "Neck_Carcinoma"                                                                                                                                                       
 [5708] "Eyelid_Carcinoma"                                                                                                                                                     
 [5709] "Eye_Carcinoma"                                                                                                                                                        
 [5710] "External_Ear_Actinic_Keratosis"                                                                                                                                       
 [5711] "External_Ear_Carcinoma"                                                                                                                                               
 [5712] "External_Ear_Basal_Cell_Carcinoma"                                                                                                                                    
 [5713] "External_Ear_Squamous_Cell_Carcinoma"                                                                                                                                 
 [5714] "External_Ear_Cyst"                                                                                                                                                    
 [5715] "Middle_Ear_Paraganglioma"                                                                                                                                             
 [5716] "Middle_Ear_Squamous_Cell_Carcinoma"                                                                                                                                   
 [5717] "External_Auditory_Canal_Sebaceous_Cyst"                                                                                                                               
 [5718] "External_Auditory_Canal_Ceruminous_Adenoma"                                                                                                                           
 [5719] "Middle_Ear_Carcinoma"                                                                                                                                                 
 [5720] "Lacrimal_Gland_Malignant_Mixed_Tumor"                                                                                                                                 
 [5721] "Lacrimal_Gland_Mucoepidermoid_Carcinoma"                                                                                                                              
 [5722] "Lacrimal_Gland_Squamous_Cell_Carcinoma"                                                                                                                               
 [5723] "Corneal_Intraepithelial_Neoplasia"                                                                                                                                    
 [5724] "Low_Grade_Corneal_Intraepithelial_Neoplasia"                                                                                                                          
 [5725] "Orbit_Sarcoma"                                                                                                                                                        
 [5726] "Low_Grade_Conjunctival_Intraepithelial_Neoplasia"                                                                                                                     
 [5727] "Iris_Spindle_Cell_Melanoma"                                                                                                                                           
 [5728] "Choroid_Spindle_Cell_Melanoma"                                                                                                                                        
 [5729] "Intermediate_Cell_Type_Choroid_Melanoma"                                                                                                                              
 [5730] "Intermediate_Cell_Type_Iris_Melanoma"                                                                                                                                 
 [5731] "Choroid_Epithelioid_Cell_Melanoma"                                                                                                                                    
 [5732] "Metastatic_Neoplasm_to_the_Iris"                                                                                                                                      
 [5733] "Benign_Uveal_Neoplasm"                                                                                                                                                
 [5734] "Malignant_Uveal_Neoplasm"                                                                                                                                             
 [5735] "Stage_I_Retinoblastoma"                                                                                                                                               
 [5736] "Stage_IA_Retinoblastoma"                                                                                                                                              
 [5737] "Stage_IB_Retinoblastoma"                                                                                                                                              
 [5738] "Stage_II_Retinoblastoma"                                                                                                                                              
 [5739] "Stage_IIA_Retinoblastoma"                                                                                                                                             
 [5740] "Stage_IIB_Retinoblastoma"                                                                                                                                             
 [5741] "Stage_IIC_Retinoblastoma"                                                                                                                                             
 [5742] "Stage_III_Retinoblastoma"                                                                                                                                             
 [5743] "Stage_IIIA_Retinoblastoma"                                                                                                                                            
 [5744] "Stage_IIIB_Retinoblastoma"                                                                                                                                            
 [5745] "Stage_IV_Retinoblastoma"                                                                                                                                              
 [5746] "Ciliary_Body_Spindle_Cell_Melanoma"                                                                                                                                   
 [5747] "Intermediate_Cell_Type_Ciliary_Body_Melanoma"                                                                                                                         
 [5748] "Ciliary_Body_Epithelioid_Cell_Melanoma"                                                                                                                               
 [5749] "Conjunctival_Intraepithelial_Neoplasia"                                                                                                                               
 [5750] "Stage_0_Laryngeal_Squamous_Cell_Carcinoma"                                                                                                                            
 [5751] "Stage_IVA_Laryngeal_Squamous_Cell_Carcinoma"                                                                                                                          
 [5752] "Stage_IVB_Laryngeal_Squamous_Cell_Carcinoma"                                                                                                                          
 [5753] "Stage_IVC_Laryngeal_Squamous_Cell_Carcinoma"                                                                                                                          
 [5754] "Stage_IVC_Laryngeal_Verrucous_Carcinoma"                                                                                                                              
 [5755] "Stage_IVB_Laryngeal_Verrucous_Carcinoma"                                                                                                                              
 [5756] "Stage_IVA_Laryngeal_Verrucous_Carcinoma"                                                                                                                              
 [5757] "Stage_0_Laryngeal_Verrucous_Carcinoma"                                                                                                                                
 [5758] "Lacrimal_Gland_Carcinoma"                                                                                                                                             
 [5759] "Stage_IVC_Hypopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                     
 [5760] "Stage_IVB_Hypopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                     
 [5761] "Stage_IVA_Hypopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                     
 [5762] "Stage_I_Thyroid_Medullary_Carcinoma"                                                                                                                                  
 [5763] "Stage_II_Thyroid_Medullary_Carcinoma"                                                                                                                                 
 [5764] "Stage_III_Thyroid_Medullary_Carcinoma"                                                                                                                                
 [5765] "Stage_IV_Thyroid_Medullary_Carcinoma"                                                                                                                                 
 [5766] "Stage_IVA_Nasopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                     
 [5767] "Stage_IVB_Nasopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                     
 [5768] "Stage_IVB_Oropharyngeal_Squamous_Cell_Carcinoma"                                                                                                                      
 [5769] "Stage_IVC_Oropharyngeal_Squamous_Cell_Carcinoma"                                                                                                                      
 [5770] "Stage_IVA_Oropharyngeal_Squamous_Cell_Carcinoma"                                                                                                                      
 [5771] "Renal_Pelvis_Carcinoma"                                                                                                                                               
 [5772] "Renal_Pelvis_Adenocarcinoma"                                                                                                                                          
 [5773] "Stage_I_Renal_Pelvis_Carcinoma"                                                                                                                                       
 [5774] "Stage_II_Renal_Pelvis_Carcinoma"                                                                                                                                      
 [5775] "Stage_III_Renal_Pelvis_Carcinoma"                                                                                                                                     
 [5776] "Stage_IV_Renal_Pelvis_Carcinoma"                                                                                                                                      
 [5777] "Renal_Pelvis_Papillary_Carcinoma"                                                                                                                                     
 [5778] "Stage_0_Ureter_Cancer"                                                                                                                                                
 [5779] "Stage_I_Ureter_Cancer"                                                                                                                                                
 [5780] "Stage_II_Ureter_Cancer"                                                                                                                                               
 [5781] "Stage_III_Ureter_Cancer"                                                                                                                                              
 [5782] "Stage_IV_Ureter_Cancer"                                                                                                                                               
 [5783] "Ureter_Squamous_Cell_Carcinoma"                                                                                                                                       
 [5784] "Ureter_Adenocarcinoma"                                                                                                                                                
 [5785] "Ureter_Transitional_Cell_Carcinoma_with_Squamous_Differentiation"                                                                                                     
 [5786] "Ureter_Transitional_Cell_Carcinoma_with_Glandular_Differentiation"                                                                                                    
 [5787] "Ureter_Transitional_Cell_Carcinoma_with_Mixed_Differentiation"                                                                                                        
 [5788] "Undifferentiated_Ureter_Carcinoma"                                                                                                                                    
 [5789] "Ureter_Papilloma"                                                                                                                                                     
 [5790] "Ureter_Leiomyoma"                                                                                                                                                     
 [5791] "Ureter_Schwannoma"                                                                                                                                                    
 [5792] "Bladder_Signet_Ring_Cell_Adenocarcinoma"                                                                                                                              
 [5793] "Bladder_Lymphoma"                                                                                                                                                     
 [5794] "Urethral_Squamous_Cell_Carcinoma"                                                                                                                                     
 [5795] "Urethral_Transitional_Cell_Carcinoma"                                                                                                                                 
 [5796] "Urethral_Adenocarcinoma"                                                                                                                                              
 [5797] "Undifferentiated_Urethral_Carcinoma"                                                                                                                                  
 [5798] "Urethra_Condyloma_Acuminatum"                                                                                                                                         
 [5799] "Urethra_Fibroepithelial_Polyp"                                                                                                                                        
 [5800] "Urethral_Leiomyoma"                                                                                                                                                   
 [5801] "Urethral_Clear_Cell_Adenocarcinoma"                                                                                                                                   
 [5802] "Urethral_Inverted_Papilloma"                                                                                                                                          
 [5803] "Ureter_Inverted_Papilloma"                                                                                                                                            
 [5804] "Ureter_Lymphoma"                                                                                                                                                      
 [5805] "Ureter_Small_Cell_Carcinoma"                                                                                                                                          
 [5806] "Urinary_Bladder_Inflammatory_Myofibroblastic_Tumor"                                                                                                                   
 [5807] "Bladder_Leiomyoma"                                                                                                                                                    
 [5808] "Bladder_Clear_Cell_Adenocarcinoma"                                                                                                                                    
 [5809] "Adult_Wilms_Tumor"                                                                                                                                                    
 [5810] "Renal_Osteosarcoma"                                                                                                                                                   
 [5811] "Renal_Pelvis_Fibroepithelial_Polyp"                                                                                                                                   
 [5812] "Renal_Leiomyosarcoma"                                                                                                                                                 
 [5813] "Renal_Liposarcoma"                                                                                                                                                    
 [5814] "Renal_Pelvis_Sarcomatoid_Transitional_Cell_Carcinoma"                                                                                                                 
 [5815] "Renal_Pelvis_Inverted_Papilloma"                                                                                                                                      
 [5816] "Stage_0_Bladder_Transitional_Cell_Carcinoma"                                                                                                                          
 [5817] "Stage_I_Bladder_Transitional_Cell_Carcinoma"                                                                                                                          
 [5818] "Inverted_Urothelial_Papilloma"                                                                                                                                        
 [5819] "Stage_0_Renal_Pelvis_Carcinoma"                                                                                                                                       
 [5820] "Collecting_Duct_Carcinoma"                                                                                                                                            
 [5821] "Stage_0_Urethral_Cancer"                                                                                                                                              
 [5822] "Stage_0a_Urethral_Cancer"                                                                                                                                             
 [5823] "Stage_I_Urethral_Cancer"                                                                                                                                              
 [5824] "Stage_II_Urethral_Cancer"                                                                                                                                             
 [5825] "Stage_III_Urethral_Cancer"                                                                                                                                            
 [5826] "Stage_IV_Urethral_Cancer"                                                                                                                                             
 [5827] "Mixed_Ureter_Carcinoma"                                                                                                                                               
 [5828] "Stage_0a_Renal_Pelvis_Carcinoma"                                                                                                                                      
 [5829] "Stage_0a_Ureter_Cancer"                                                                                                                                               
 [5830] "Childhood_Central_Nervous_System_Teratoma"                                                                                                                            
 [5831] "Childhood_Central_Nervous_System_Germ_Cell_Neoplasm"                                                                                                                  
 [5832] "Childhood_Central_Nervous_System_Choriocarcinoma"                                                                                                                     
 [5833] "Childhood_Brain_Germinoma"                                                                                                                                            
 [5834] "Childhood_Central_Nervous_System_Embryonal_Carcinoma"                                                                                                                 
 [5835] "Childhood_Central_Nervous_System_Yolk_Sac_Tumor"                                                                                                                      
 [5836] "Soft_Palate_Benign_Granular_Cell_Tumor"                                                                                                                               
 [5837] "Soft_Palate_Pleomorphic_Adenoma"                                                                                                                                      
 [5838] "Hard_Palate_Pleomorphic_Adenoma"                                                                                                                                      
 [5839] "Hard_Palate_Adenoid_Cystic_Carcinoma"                                                                                                                                 
 [5840] "Hard_Palate_Mucoepidermoid_Carcinoma"                                                                                                                                 
 [5841] "Childhood_Anaplastic_Astrocytoma"                                                                                                                                     
 [5842] "Childhood_Brain_Stem_Astrocytoma"                                                                                                                                     
 [5843] "Recurrent_Childhood_Brain_Stem_Astrocytoma"                                                                                                                           
 [5844] "Benign_Adult_Cerebral_Neoplasm"                                                                                                                                       
 [5845] "Benign_Childhood_Cerebral_Neoplasm"                                                                                                                                   
 [5846] "Cerebral_Hemisphere_Lipoma"                                                                                                                                           
 [5847] "Thalamic_Neoplasm"                                                                                                                                                    
 [5848] "Benign_Thalamic_Neoplasm"                                                                                                                                             
 [5849] "Conjunctival_Squamous_Cell_Papilloma"                                                                                                                                 
 [5850] "Stage_IVC_Nasopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                     
 [5851] "Ethmoid_Sinus_Adenocarcinoma"                                                                                                                                         
 [5852] "Ethmoid_Sinus_Adenoid_Cystic_Carcinoma"                                                                                                                               
 [5853] "Maxillary_Sinus_Adenoid_Cystic_Carcinoma"                                                                                                                             
 [5854] "Maxillary_Sinus_Adenocarcinoma"                                                                                                                                       
 [5855] "Oropharyngeal_Adenoid_Cystic_Carcinoma"                                                                                                                               
 [5856] "Oral_Cavity_Pleomorphic_Adenoma"                                                                                                                                      
 [5857] "Minor_Salivary_Gland_Acinic_Cell_Carcinoma"                                                                                                                           
 [5858] "Orbit_Lymphoma"                                                                                                                                                       
 [5859] "Orbit_Hemangioma"                                                                                                                                                     
 [5860] "Orbit_Embryonal_Rhabdomyosarcoma"                                                                                                                                     
 [5861] "Orbit_Alveolar_Rhabdomyosarcoma"                                                                                                                                      
 [5862] "Tracheal_Lymphoma"                                                                                                                                                    
 [5863] "Anterior_Tongue_Carcinoma"                                                                                                                                            
 [5864] "Anterior_Tongue_Mucoepidermoid_Carcinoma"                                                                                                                             
 [5865] "Anterior_Tongue_Adenoid_Cystic_Carcinoma"                                                                                                                             
 [5866] "Childhood_Brain_Anaplastic_Astrocytoma"                                                                                                                               
 [5867] "Childhood_Brain_Meningioma"                                                                                                                                           
 [5868] "Stage_IIA_Nasopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                     
 [5869] "Stage_IIB_Nasopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                     
 [5870] "Ovarian_Serous_Surface_Papillary_Carcinoma"                                                                                                                           
 [5871] "Ovarian_Endometrioid_Tumor"                                                                                                                                           
 [5872] "Stage_IIIA_Ovarian_Cancer"                                                                                                                                            
 [5873] "Stage_IIIB_Ovarian_Cancer"                                                                                                                                            
 [5874] "Stage_IIIC_Ovarian_Cancer"                                                                                                                                            
 [5875] "Ovarian_Granulosa_Cell_Tumor"                                                                                                                                         
 [5876] "Visual_Pathway_Neoplasm"                                                                                                                                              
 [5877] "Malignant_Ovarian_Luteinized_Thecoma"                                                                                                                                 
 [5878] "Benign_Ovarian_Luteinized_Thecoma"                                                                                                                                    
 [5879] "Fallopian_Tube_Adenocarcinoma"                                                                                                                                        
 [5880] "Pineal_Gland_Glial_Cyst"                                                                                                                                              
 [5881] "Fallopian_Tube_Papillary_Adenocarcinoma"                                                                                                                              
 [5882] "Childhood_Cerebral_Ependymoma"                                                                                                                                        
 [5883] "Stage_IA_Fallopian_Tube_Cancer"                                                                                                                                       
 [5884] "Stage_IB_Fallopian_Tube_Cancer"                                                                                                                                       
 [5885] "Stage_IC_Fallopian_Tube_Cancer"                                                                                                                                       
 [5886] "Stage_IIA_Fallopian_Tube_Cancer"                                                                                                                                      
 [5887] "Stage_IIIA_Fallopian_Tube_Cancer"                                                                                                                                     
 [5888] "Stage_IIIB_Fallopian_Tube_Cancer"                                                                                                                                     
 [5889] "Stage_IIIC_Fallopian_Tube_Cancer"                                                                                                                                     
 [5890] "Stage_IIC_Fallopian_Tube_Cancer"                                                                                                                                      
 [5891] "Stage_IIB_Fallopian_Tube_Cancer"                                                                                                                                      
 [5892] "Fallopian_Tube_Gestational_Choriocarcinoma"                                                                                                                           
 [5893] "Fallopian_Tube_Endometrioid_Adenocarcinoma"                                                                                                                           
 [5894] "Fallopian_Tube_Clear_Cell_Adenocarcinoma"                                                                                                                             
 [5895] "Undifferentiated_Fallopian_Tube_Carcinoma"                                                                                                                            
 [5896] "Fallopian_Tube_Squamous_Cell_Carcinoma"                                                                                                                               
 [5897] "Childhood_Neoplasm"                                                                                                                                                   
 [5898] "Brain_Germinoma"                                                                                                                                                      
 [5899] "Adult_Central_Nervous_System_Germ_Cell_Neoplasm"                                                                                                                      
 [5900] "Childhood_Cerebellar_Astrocytoma"                                                                                                                                     
 [5901] "Uterine_Corpus_Endometrioid_Adenocarcinoma"                                                                                                                           
 [5902] "Endometrial_Adenosquamous_Carcinoma"                                                                                                                                  
 [5903] "Stage_IA_Ovarian_Germ_Cell_Tumor"                                                                                                                                     
 [5904] "Stage_IB_Ovarian_Germ_Cell_Tumor"                                                                                                                                     
 [5905] "Stage_IC_Ovarian_Germ_Cell_Tumor"                                                                                                                                     
 [5906] "Stage_IIC_Ovarian_Germ_Cell_Tumor"                                                                                                                                    
 [5907] "Stage_IIB_Ovarian_Germ_Cell_Tumor"                                                                                                                                    
 [5908] "Stage_IIA_Ovarian_Germ_Cell_Tumor"                                                                                                                                    
 [5909] "Stage_IIIA_Ovarian_Germ_Cell_Tumor"                                                                                                                                   
 [5910] "Stage_IIIB_Ovarian_Germ_Cell_Tumor"                                                                                                                                   
 [5911] "Stage_IIIC_Ovarian_Germ_Cell_Tumor"                                                                                                                                   
 [5912] "Uterine_Corpus_Neoplasm"                                                                                                                                              
 [5913] "Stage_IA_Endometrial_Cancer"                                                                                                                                          
 [5914] "Stage_IB_Endometrial_Cancer"                                                                                                                                          
 [5915] "Stage_IC_Endometrial_Cancer"                                                                                                                                          
 [5916] "Stage_IIA_Endometrial_Cancer"                                                                                                                                         
 [5917] "Stage_IIB_Endometrial_Cancer"                                                                                                                                         
 [5918] "Stage_IIIA_Endometrial_Cancer"                                                                                                                                        
 [5919] "Stage_IIIB_Endometrial_Cancer"                                                                                                                                        
 [5920] "Stage_IIIC_Endometrial_Cancer"                                                                                                                                        
 [5921] "Stage_IVA_Endometrial_Cancer"                                                                                                                                         
 [5922] "Stage_IVB_Endometrial_Cancer"                                                                                                                                         
 [5923] "Malignant_Uterine_Corpus_Mixed_Neoplasm"                                                                                                                              
 [5924] "Stage_IA_Cervical_Cancer"                                                                                                                                             
 [5925] "Stage_IA1_Cervical_Cancer"                                                                                                                                            
 [5926] "Stage_IA2_Cervical_Cancer"                                                                                                                                            
 [5927] "Stage_IB_Cervical_Cancer"                                                                                                                                             
 [5928] "Stage_IB1_Cervical_Cancer"                                                                                                                                            
 [5929] "Stage_IB2_Cervical_Cancer"                                                                                                                                            
 [5930] "Stage_IIA_Cervical_Cancer"                                                                                                                                            
 [5931] "Stage_IIB_Cervical_Cancer"                                                                                                                                            
 [5932] "Stage_IIIB_Cervical_Cancer"                                                                                                                                           
 [5933] "Stage_IIIA_Cervical_Cancer"                                                                                                                                           
 [5934] "Stage_IVA_Cervical_Cancer"                                                                                                                                            
 [5935] "Stage_IVB_Cervical_Cancer"                                                                                                                                            
 [5936] "Vaginal_Verrucous_Carcinoma"                                                                                                                                          
 [5937] "Vaginal_Leiomyosarcoma"                                                                                                                                               
 [5938] "Vaginal_Embryonal_Rhabdomyosarcoma"                                                                                                                                   
 [5939] "Stage_IA_Vulvar_Carcinoma"                                                                                                                                            
 [5940] "Stage_IB_Vulvar_Carcinoma"                                                                                                                                            
 [5941] "Stage_IVA_Vulvar_Cancer"                                                                                                                                              
 [5942] "Metastasis_to_the_Vulva"                                                                                                                                              
 [5943] "Metastasis_to_the_Vagina"                                                                                                                                             
 [5944] "Metastatic_Carcinoma_to_the_Uterine_Cervix"                                                                                                                           
 [5945] "Benign_Uterine_Corpus_Mixed_Neoplasm"                                                                                                                                 
 [5946] "Uterine_Corpus_Mullerian_Adenosarcoma"                                                                                                                                
 [5947] "Uterine_Corpus_Adenofibroma"                                                                                                                                          
 [5948] "Uterine_Corpus_Adenomyoma"                                                                                                                                            
 [5949] "Uterine_Corpus_Sarcoma"                                                                                                                                               
 [5950] "Uterine_Corpus_Leiomyosarcoma"                                                                                                                                        
 [5951] "Testicular_Embryonal_Carcinoma"                                                                                                                                       
 [5952] "Uterine_Cervix_Squamous_Papilloma"                                                                                                                                    
 [5953] "Cervical_Endometrioid_Adenocarcinoma"                                                                                                                                 
 [5954] "Cervical_Clear_Cell_Carcinoma"                                                                                                                                        
 [5955] "Undifferentiated_Cervical_Carcinoma"                                                                                                                                  
 [5956] "Cervical_Adenoid_Cystic_Carcinoma"                                                                                                                                    
 [5957] "Testicular_Mixed_Germ_Cell_Neoplasm"                                                                                                                                  
 [5958] "Testicular_Mixed_Choriocarcinoma_and_Embryonal_Carcinoma"                                                                                                             
 [5959] "Testicular_Mixed_Choriocarcinoma_and_Teratoma"                                                                                                                        
 [5960] "Testicular_Mixed_Embryonal_Carcinoma_and_Seminoma"                                                                                                                    
 [5961] "Testicular_Mixed_Embryonal_Carcinoma_and_Teratoma"                                                                                                                    
 [5962] "Testicular_Mixed_Embryonal_Carcinoma_and_Teratoma_with_Seminoma"                                                                                                      
 [5963] "Immature_Testicular_Teratoma"                                                                                                                                         
 [5964] "Classic_Seminoma"                                                                                                                                                     
 [5965] "Mature_Testicular_Teratoma"                                                                                                                                           
 [5966] "Testicular_Leydig_Cell_Tumor"                                                                                                                                         
 [5967] "Testicular_Granulosa_Cell_Tumor"                                                                                                                                      
 [5968] "Testicular_Sex_Cord-Stromal_Tumor"                                                                                                                                    
 [5969] "Testicular_Sarcoma"                                                                                                                                                   
 [5970] "Testicular_Carcinoid_Tumor"                                                                                                                                           
 [5971] "Stage_IA_Testicular_Cancer"                                                                                                                                           
 [5972] "Stage_IB_Testicular_Cancer"                                                                                                                                           
 [5973] "Stage_IC_Testicular_Cancer"                                                                                                                                           
 [5974] "Stage_IIA_Testicular_Cancer"                                                                                                                                          
 [5975] "Stage_IIB_Testicular_Cancer"                                                                                                                                          
 [5976] "Stage_IIC_Testicular_Cancer"                                                                                                                                          
 [5977] "Stage_IIIC_Testicular_Cancer"                                                                                                                                         
 [5978] "Stage_IIIB_Testicular_Cancer"                                                                                                                                         
 [5979] "Stage_IIIA_Testicular_Cancer"                                                                                                                                         
 [5980] "Testicular_Epidermoid_Cyst"                                                                                                                                           
 [5981] "Giant_Condyloma_Acuminatum"                                                                                                                                           
 [5982] "Vaginal_Rhabdomyoma"                                                                                                                                                  
 [5983] "Vaginal_Leiomyoma"                                                                                                                                                    
 [5984] "Vaginal_Squamous_Papilloma"                                                                                                                                           
 [5985] "Vulvar_Seborrheic_Keratosis"                                                                                                                                          
 [5986] "Vulvar_Squamous_Papilloma"                                                                                                                                            
 [5987] "Penile_Kaposi_s_Sarcoma"                                                                                                                                              
 [5988] "Testicular_Rhabdomyosarcoma"                                                                                                                                          
 [5989] "Vaginal_Yolk_Sac_Tumor"                                                                                                                                               
 [5990] "Vulvar_Adenocarcinoma"                                                                                                                                                
 [5991] "Vulvar_Basal_Cell_Carcinoma"                                                                                                                                          
 [5992] "Epididymal_Adenomatoid_Tumor"                                                                                                                                         
 [5993] "Vulvar_Verrucous_Carcinoma"                                                                                                                                           
 [5994] "Paratesticular_Lipoma"                                                                                                                                                
 [5995] "Metastasis_to_the_Cervix"                                                                                                                                             
 [5996] "Scrotal_Basal_Cell_Carcinoma"                                                                                                                                         
 [5997] "Scrotal_Hemangioma"                                                                                                                                                   
 [5998] "Scrotal_Epidermoid_Cyst"                                                                                                                                              
 [5999] "Scrotal_Carcinoma"                                                                                                                                                    
 [6000] "Gestational_Trophoblastic_Tumor_by_FIGO_Stage"                                                                                                                        
 [6001] "FIGO_Stage_I_Gestational_Trophoblastic_Tumor"                                                                                                                         
 [6002] "FIGO_Stage_IA_Gestational_Trophoblastic_Tumor"                                                                                                                        
 [6003] "Invasive_Ductal_and_Invasive_Lobular_Breast_Carcinoma"                                                                                                                
 [6004] "FIGO_Stage_IB_Gestational_Trophoblastic_Tumor"                                                                                                                        
 [6005] "FIGO_Stage_IC_Gestational_Trophoblastic_Tumor"                                                                                                                        
 [6006] "FIGO_Stage_II_Gestational_Trophoblastic_Tumor"                                                                                                                        
 [6007] "FIGO_Stage_IIA_Gestational_Trophoblastic_Tumor"                                                                                                                       
 [6008] "FIGO_Stage_IIB_Gestational_Trophoblastic_Tumor"                                                                                                                       
 [6009] "FIGO_Stage_IIC_Gestational_Trophoblastic_Tumor"                                                                                                                       
 [6010] "FIGO_Stage_III_Gestational_Trophoblastic_Tumor"                                                                                                                       
 [6011] "FIGO_Stage_IIIA_Gestational_Trophoblastic_Tumor"                                                                                                                      
 [6012] "FIGO_Stage_IIIB_Gestational_Trophoblastic_Tumor"                                                                                                                      
 [6013] "FIGO_Stage_IIIC_Gestational_Trophoblastic_Tumor"                                                                                                                      
 [6014] "FIGO_Stage_IV_Gestational_Trophoblastic_Tumor"                                                                                                                        
 [6015] "FIGO_Stage_IVA_Gestational_Trophoblastic_Tumor"                                                                                                                       
 [6016] "FIGO_Stage_IVB_Gestational_Trophoblastic_Tumor"                                                                                                                       
 [6017] "FIGO_Stage_IVC_Gestational_Trophoblastic_Tumor"                                                                                                                       
 [6018] "Orbit_Paraganglioma"                                                                                                                                                  
 [6019] "Laryngeal_Paraganglioma"                                                                                                                                              
 [6020] "Cardiac_Paraganglioma"                                                                                                                                                
 [6021] "Intrathoracic_Paravertebral_Paraganglioma"                                                                                                                            
 [6022] "Malignant_Intrathoracic_Paravertebral_Paraganglioma"                                                                                                                  
 [6023] "Bladder_Paraganglioma"                                                                                                                                                
 [6024] "Malignant_Bladder_Paraganglioma"                                                                                                                                      
 [6025] "Recurrent_Adrenal_Cortex_Cancer"                                                                                                                                      
 [6026] "Ovarian_Liposarcoma"                                                                                                                                                  
 [6027] "Aortic_Paraganglioma"                                                                                                                                                 
 [6028] "Foregut_Carcinoid_Tumor"                                                                                                                                              
 [6029] "Midgut_Carcinoid_Tumor"                                                                                                                                               
 [6030] "Hindgut_Carcinoid_Tumor"                                                                                                                                              
 [6031] "Meckel_s_Diverticulum_Carcinoid_Tumor"                                                                                                                                
 [6032] "Duodenal_Carcinoid_Tumor"                                                                                                                                             
 [6033] "Transverse_Colon_Carcinoid_Tumor"                                                                                                                                     
 [6034] "Ascending_Colon_Carcinoid_Tumor"                                                                                                                                      
 [6035] "Descending_Colon_Carcinoid_Tumor"                                                                                                                                     
 [6036] "Jejunal_Carcinoid_Tumor"                                                                                                                                              
 [6037] "Thymus_Carcinoid_Tumor"                                                                                                                                               
 [6038] "Metastatic_Carcinoid_Tumor"                                                                                                                                           
 [6039] "Multiple_Endocrine_Neoplasia"                                                                                                                                         
 [6040] "Endometrial_Polyp"                                                                                                                                                    
 [6041] "Bartholin_s_Gland_Neoplasm"                                                                                                                                           
 [6042] "Mediastinal_Germ_Cell_Neoplasm"                                                                                                                                       
 [6043] "Mediastinal_Teratoma"                                                                                                                                                 
 [6044] "Mediastinal_Malignant_Non-Seminomatous_Germ_Cell_Neoplasm"                                                                                                            
 [6045] "Mediastinal_Choriocarcinoma"                                                                                                                                          
 [6046] "Mediastinal_Embryonal_Carcinoma"                                                                                                                                      
 [6047] "Mediastinal_Mixed_Embryonal_Carcinoma_and_Teratoma"                                                                                                                   
 [6048] "Mediastinal_Yolk_Sac_Tumor"                                                                                                                                           
 [6049] "Mediastinal_Mixed_Non-Seminomatous_Germ_Cell_Neoplasm"                                                                                                                
 [6050] "Benign_Mediastinal_Germ_Cell_Neoplasm"                                                                                                                                
 [6051] "Malignant_Mediastinal_Germ_Cell_Neoplasm"                                                                                                                             
 [6052] "Retroperitoneal_Germ_Cell_Neoplasm"                                                                                                                                   
 [6053] "Gastric_Germ_Cell_Neoplasm"                                                                                                                                           
 [6054] "Benign_Germ_Cell_Neoplasm"                                                                                                                                            
 [6055] "Thymus_Epithelial_Neoplasm"                                                                                                                                           
 [6056] "Thymic_Lymphoma"                                                                                                                                                      
 [6057] "Thymic_Lipoma"                                                                                                                                                        
 [6058] "Invasive_Thymoma"                                                                                                                                                     
 [6059] "Thymoma_Type_A"                                                                                                                                                       
 [6060] "Squamous_Cell_Thymic_Carcinoma"                                                                                                                                       
 [6061] "Basaloid_Thymic_Carcinoma"                                                                                                                                            
 [6062] "Mucoepidermoid_Thymic_Carcinoma"                                                                                                                                      
 [6063] "Adenosquamous_Thymic_Carcinoma"                                                                                                                                       
 [6064] "Thymic_Adenocarcinoma"                                                                                                                                                
 [6065] "Small_Cell_Thymic_Carcinoma"                                                                                                                                          
 [6066] "Large_Cell_Thymic_Carcinoma"                                                                                                                                          
 [6067] "Clear_Cell_Thymic_Carcinoma"                                                                                                                                          
 [6068] "Sarcomatoid_Thymic_Carcinoma"                                                                                                                                         
 [6069] "Stage_IA_Bone_Sarcoma"                                                                                                                                                
 [6070] "Stage_IB_Bone_Sarcoma"                                                                                                                                                
 [6071] "Stage_IIB_Bone_Sarcoma"                                                                                                                                               
 [6072] "Stage_IIA_Bone_Sarcoma"                                                                                                                                               
 [6073] "Stage_III_Bone_Sarcoma"                                                                                                                                               
 [6074] "Osteosarcoma_Arising_in_Paget_s_Disease_of_Bone"                                                                                                                      
 [6075] "Multifocal_Osteosarcoma"                                                                                                                                              
 [6076] "Synchronous_Multifocal_Osteosarcoma"                                                                                                                                  
 [6077] "Asynchronous_Multifocal_Osteosarcoma"                                                                                                                                 
 [6078] "Intracortical_Osteosarcoma"                                                                                                                                           
 [6079] "Low_Grade_Central_Osteosarcoma"                                                                                                                                       
 [6080] "Clear_Cell_Chondrosarcoma"                                                                                                                                            
 [6081] "Dedifferentiated_Chondrosarcoma"                                                                                                                                      
 [6082] "Bone_Hemangioma"                                                                                                                                                      
 [6083] "Vascular_Bone_Neoplasm"                                                                                                                                               
 [6084] "Bone_Angiosarcoma"                                                                                                                                                    
 [6085] "Bone_Glomus_Tumor"                                                                                                                                                    
 [6086] "Inflammatory_Myofibroblastic_Tumor"                                                                                                                                   
 [6087] "Atypical_Decubital_Fibroplasia"                                                                                                                                       
 [6088] "Dermal_Fibroma"                                                                                                                                                       
 [6089] "Tendon_Sheath_Fibroma"                                                                                                                                                
 [6090] "Nuchal_Fibroma"                                                                                                                                                       
 [6091] "Multicentric_Myofibromatosis"                                                                                                                                         
 [6092] "Calcifying_Fibrous_Pseudotumor"                                                                                                                                       
 [6093] "Extraabdominal_Fibromatosis"                                                                                                                                          
 [6094] "Benign_Fibrohistiocytic_Neoplasm"                                                                                                                                     
 [6095] "Intermediate_Fibrohistiocytic_Neoplasm"                                                                                                                               
 [6096] "Benign_Deep_Fibrous_Histiocytoma"                                                                                                                                     
 [6097] "Plexiform_Fibrohistiocytic_Tumor"                                                                                                                                     
 [6098] "Angiomatoid_Fibrous_Histiocytoma"                                                                                                                                     
 [6099] "Storiform-Pleomorphic_Malignant_Fibrous_Histiocytoma"                                                                                                                 
 [6100] "Myxoid_Malignant_Fibrous_Histiocytoma"                                                                                                                                
 [6101] "Inflammatory_Malignant_Fibrous_Histiocytoma"                                                                                                                          
 [6102] "Deep_Lipoma"                                                                                                                                                          
 [6103] "Tendon_Sheath_Lipoma"                                                                                                                                                 
 [6104] "Lumbosacral_Lipoma"                                                                                                                                                   
 [6105] "Chondroid_Lipoma"                                                                                                                                                     
 [6106] "Diffuse_Lipomatosis"                                                                                                                                                  
 [6107] "Atypical_Lipoma"                                                                                                                                                      
 [6108] "Sclerosing_Liposarcoma"                                                                                                                                               
 [6109] "Inflammatory_Liposarcoma"                                                                                                                                             
 [6110] "Fibroblastic_Liposarcoma"                                                                                                                                             
 [6111] "Benign_Smooth_Muscle_Neoplasm"                                                                                                                                        
 [6112] "Malignant_Smooth_Muscle_Neoplasm"                                                                                                                                     
 [6113] "Deep_Leiomyoma"                                                                                                                                                       
 [6114] "Pleomorphic_Leiomyoma"                                                                                                                                                
 [6115] "Skeletal_Muscle_Neoplasm"                                                                                                                                             
 [6116] "Benign_Skeletal_Muscle_Neoplasm"                                                                                                                                      
 [6117] "Malignant_Skeletal_Muscle_Neoplasm"                                                                                                                                   
 [6118] "Genital_Rhabdomyoma"                                                                                                                                                  
 [6119] "Intermediate_Rhabdomyoma"                                                                                                                                             
 [6120] "Spindle_Cell_Rhabdomyosarcoma"                                                                                                                                        
 [6121] "Benign_Testicular_Sertoli_Cell_Tumor"                                                                                                                                 
 [6122] "Malignant_Testicular_Sertoli_Cell_Tumor"                                                                                                                              
 [6123] "Benign_Lymphatic_Vessel_Neoplasm"                                                                                                                                     
 [6124] "Synovial_Hemangioma"                                                                                                                                                  
 [6125] "Perineural_Hemangioma"                                                                                                                                                
 [6126] "Alloimmunization"                                                                                                                                                     
 [6127] "Perivascular_Neoplasm"                                                                                                                                                
 [6128] "Benign_Perivascular_Neoplasm"                                                                                                                                         
 [6129] "Malignant_Perivascular_Neoplasm"                                                                                                                                      
 [6130] "Malignant_Synovial_Neoplasm"                                                                                                                                          
 [6131] "Localized_Giant_Cell_Tumor_of_Tendon_Sheath"                                                                                                                          
 [6132] "Fibrous_Synovial_Sarcoma"                                                                                                                                             
 [6133] "Monophasic_Synovial_Sarcoma"                                                                                                                                          
 [6134] "Malignant_Giant_Cell_Tumor_of_Tendon_Sheath"                                                                                                                          
 [6135] "Multicystic_Peritoneal_Mesothelioma"                                                                                                                                  
 [6136] "Stage_I_Soft_Tissue_Sarcoma"                                                                                                                                          
 [6137] "Stage_II_Soft_Tissue_Sarcoma"                                                                                                                                         
 [6138] "Childhood_Testicular_Mixed_Embryonal_Carcinoma_and_Teratoma"                                                                                                          
 [6139] "Childhood_Testicular_Teratoma"                                                                                                                                        
 [6140] "Malignant_Childhood_Germ_Cell_Tumor"                                                                                                                                  
 [6141] "Childhood_Testicular_Mixed_Germ_Cell_Neoplasm"                                                                                                                        
 [6142] "Childhood_Testicular_Yolk_Sac_Tumor"                                                                                                                                  
 [6143] "Childhood_Testicular_Choriocarcinoma"                                                                                                                                 
 [6144] "Childhood_Testicular_Embryonal_Carcinoma"                                                                                                                             
 [6145] "Childhood_Ovarian_Embryonal_Carcinoma"                                                                                                                                
 [6146] "Childhood_Ovarian_Immature_Teratoma"                                                                                                                                  
 [6147] "Childhood_Ovarian_Mature_Teratoma"                                                                                                                                    
 [6148] "Childhood_Ovarian_Choriocarcinoma"                                                                                                                                    
 [6149] "Childhood_Ovarian_Dysgerminoma"                                                                                                                                       
 [6150] "Childhood_Ovarian_Yolk_Sac_Tumor"                                                                                                                                     
 [6151] "Childhood_Testicular_Germ_Cell_Tumor"                                                                                                                                 
 [6152] "Benign_Childhood_Germ_Cell_Neoplasm"                                                                                                                                  
 [6153] "Childhood_Ovarian_Teratoma"                                                                                                                                           
 [6154] "Deep_Hemangioma"                                                                                                                                                      
 [6155] "Degenerated_Schwannoma"                                                                                                                                               
 [6156] "Schwannomatosis"                                                                                                                                                      
 [6157] "Epithelioid_Neurofibroma"                                                                                                                                             
 [6158] "Multiple_Mucosal_Neuromas"                                                                                                                                            
 [6159] "Glandular_Malignant_Peripheral_Nerve_Sheath_Tumor"                                                                                                                    
 [6160] "Epithelioid_Malignant_Peripheral_Nerve_Sheath_Tumor"                                                                                                                  
 [6161] "Childhood_Renal_Neoplasm"                                                                                                                                             
 [6162] "Childhood_Renal_Clear_Cell_Sarcoma"                                                                                                                                   
 [6163] "Childhood_Renal_Angiomyolipoma"                                                                                                                                       
 [6164] "Childhood_Multilocular_Cystic_Renal_Neoplasm"                                                                                                                         
 [6165] "Childhood_Renal_Cell_Carcinoma"                                                                                                                                       
 [6166] "Childhood_Congenital_Mesoblastic_Nephroma"                                                                                                                            
 [6167] "Extraskeletal_Cartilaginous_and_Osseous_Neoplasm"                                                                                                                     
 [6168] "Benign_Extraskeletal_Cartilaginous_and_Osseous_Neoplasm"                                                                                                              
 [6169] "Malignant_Extraskeletal_Cartilaginous_and_Osseous_Neoplasm"                                                                                                           
 [6170] "Fibroosseous_Pseudotumor_of_the_Digits"                                                                                                                               
 [6171] "Extraskeletal_Osteochondroma"                                                                                                                                         
 [6172] "Extraskeletal_Osteoma"                                                                                                                                                
 [6173] "Myxoma"                                                                                                                                                               
 [6174] "Cutaneous_Myxoma"                                                                                                                                                     
 [6175] "Intramuscular_Myxoma"                                                                                                                                                 
 [6176] "Juxtaarticular_Myxoma"                                                                                                                                                
 [6177] "Parachordoma"                                                                                                                                                         
 [6178] "Ossifying_Fibromyxoid_Neoplasm"                                                                                                                                       
 [6179] "Nonossifying_Fibromyxoid_Neoplasm"                                                                                                                                    
 [6180] "Palisaded_Lymph_Node_Myofibroblastoma"                                                                                                                                
 [6181] "Childhood_Osteosarcoma"                                                                                                                                               
 [6182] "Extrarenal_Rhabdoid_Tumor"                                                                                                                                            
 [6183] "Benign_Miscellaneous_Mesenchymal_Neoplasm"                                                                                                                            
 [6184] "Malignant_Miscellaneous_Mesenchymal_Neoplasm"                                                                                                                         
 [6185] "Childhood_Parosteal_Osteosarcoma"                                                                                                                                     
 [6186] "Childhood_Intracortical_Osteosarcoma"                                                                                                                                 
 [6187] "Peripheral_Neuroblastoma"                                                                                                                                             
 [6188] "Panniculitis_Ossificans"                                                                                                                                              
 [6189] "Benign_Mesenchymal_Mediastinal_Neoplasm"                                                                                                                              
 [6190] "Peripheral_Ganglioneuroblastoma"                                                                                                                                      
 [6191] "Mediastinal_Lymphangioma"                                                                                                                                             
 [6192] "Mediastinal_Chondroma"                                                                                                                                                
 [6193] "Benign_Mediastinal_Hemangiopericytoma"                                                                                                                                
 [6194] "Mediastinal_Leiomyoma"                                                                                                                                                
 [6195] "Mediastinal_Lipoma"                                                                                                                                                   
 [6196] "Mediastinal_Rhabdomyoma"                                                                                                                                              
 [6197] "Mediastinal_Granular_Cell_Tumor"                                                                                                                                      
 [6198] "Benign_Osteogenic_Neoplasm"                                                                                                                                           
 [6199] "Osteogenic_Neoplasm"                                                                                                                                                  
 [6200] "Bone_Fibrosarcoma"                                                                                                                                                    
 [6201] "Soft_Tissue_Fibrosarcoma"                                                                                                                                             
 [6202] "Mediastinal_Sarcoma"                                                                                                                                                  
 [6203] "Stage_IA_Osteosarcoma"                                                                                                                                                
 [6204] "Malignant_Mediastinal_Hemangiopericytoma"                                                                                                                             
 [6205] "Stage_IB_Osteosarcoma"                                                                                                                                                
 [6206] "Stage_IIA_Osteosarcoma"                                                                                                                                               
 [6207] "Stage_IIB_Osteosarcoma"                                                                                                                                               
 [6208] "Stage_III_Osteosarcoma"                                                                                                                                               
 [6209] "Mediastinal_Angiosarcoma"                                                                                                                                             
 [6210] "Mediastinal_Liposarcoma"                                                                                                                                              
 [6211] "Mediastinal_Osteosarcoma"                                                                                                                                             
 [6212] "Mediastinal_Rhabdomyosarcoma"                                                                                                                                         
 [6213] "Mediastinal_Synovial_Sarcoma"                                                                                                                                         
 [6214] "Mediastinal_Leiomyosarcoma"                                                                                                                                           
 [6215] "Bone_Lymphoma"                                                                                                                                                        
 [6216] "Metastatic_Bone_Ewing_s_Sarcoma"                                                                                                                                      
 [6217] "Recurrent_Bone_Ewing_s_Sarcoma"                                                                                                                                       
 [6218] "Localized_Bone_Ewing_s_Sarcoma"                                                                                                                                       
 [6219] "Mediastinal_Neural_Neoplasm"                                                                                                                                          
 [6220] "Benign_Mediastinal_Schwannoma"                                                                                                                                        
 [6221] "Mediastinal_Malignant_Peripheral_Nerve_Sheath_Tumor"                                                                                                                  
 [6222] "Mediastinal_Ganglioneuroblastoma"                                                                                                                                     
 [6223] "Mediastinal_Neuroblastoma"                                                                                                                                            
 [6224] "Malignant_Melanocytic_Peripheral_Nerve_Sheath_Tumor_of_the_Mediastinum"                                                                                               
 [6225] "Mediastinal_Neurofibroma"                                                                                                                                             
 [6226] "Mediastinal_Ganglioneuroma"                                                                                                                                           
 [6227] "Mediastinal_Lymphoma"                                                                                                                                                 
 [6228] "Mediastinal_Hodgkin_s_Lymphoma"                                                                                                                                       
 [6229] "Mediastinal_Melanocytic_Schwannoma"                                                                                                                                   
 [6230] "Benign_Mediastinal_Psammomatous_Schwannoma"                                                                                                                           
 [6231] "Mediastinal_Mesenchymal_Neoplasm"                                                                                                                                     
 [6232] "Stage_I_Neuroblastoma"                                                                                                                                                
 [6233] "Stage_II_Neuroblastoma"                                                                                                                                               
 [6234] "Stage_III_Neuroblastoma"                                                                                                                                              
 [6235] "Stage_IV_Neuroblastoma"                                                                                                                                               
 [6236] "Malignant_Mediastinal_Mesenchymal_Neoplasm"                                                                                                                           
 [6237] "Mediastinal_Schwannoma"                                                                                                                                               
 [6238] "Pleural_Lipoma"                                                                                                                                                       
 [6239] "Infantile_Hemangioendothelioma"                                                                                                                                       
 [6240] "Stage_I_Pleural_Mesothelioma"                                                                                                                                         
 [6241] "Stage_II_Pleural_Mesothelioma"                                                                                                                                        
 [6242] "Stage_III_Pleural_Mesothelioma"                                                                                                                                       
 [6243] "Stage_IV_Pleural_Mesothelioma"                                                                                                                                        
 [6244] "Ampulla_of_Vater_Adenocarcinoma"                                                                                                                                      
 [6245] "Stage_I_Ampulla_of_Vater_Cancer"                                                                                                                                      
 [6246] "Stage_II_Ampulla_of_Vater_Cancer"                                                                                                                                     
 [6247] "Stage_III_Ampulla_of_Vater_Cancer"                                                                                                                                    
 [6248] "Stage_IV_Ampulla_of_Vater_Cancer"                                                                                                                                     
 [6249] "Ampulla_of_Vater_Small_Cell_Carcinoma"                                                                                                                                
 [6250] "Ampulla_of_Vater_Signet_Ring_Cell_Carcinoma"                                                                                                                          
 [6251] "Ampulla_of_Vater_Adenoma"                                                                                                                                             
 [6252] "Ampulla_of_Vater_Villous_Adenoma"                                                                                                                                     
 [6253] "Ampulla_of_Vater_Tubular_Adenoma"                                                                                                                                     
 [6254] "Stage_II_Large_Cell_Lung_Carcinoma"                                                                                                                                   
 [6255] "Stage_IA_Large_Cell_Lung_Carcinoma"                                                                                                                                   
 [6256] "Stage_IB_Large_Cell_Lung_Carcinoma"                                                                                                                                   
 [6257] "Stage_IIB_Large_Cell_Lung_Carcinoma"                                                                                                                                  
 [6258] "Stage_IIIB_Large_Cell_Lung_Carcinoma"                                                                                                                                 
 [6259] "Stage_IIIA_Large_Cell_Lung_Carcinoma"                                                                                                                                 
 [6260] "Stage_IIA_Large_Cell_Lung_Carcinoma"                                                                                                                                  
 [6261] "Stage_IIA_Adenosquamous_Lung_Carcinoma"                                                                                                                               
 [6262] "Stage_IA_Adenosquamous_Cell_Lung_Carcinoma"                                                                                                                           
 [6263] "Stage_IB_Adenosquamous_Cell_Lung_Carcinoma"                                                                                                                           
 [6264] "Stage_IIB_Adenosquamous_Lung_Carcinoma"                                                                                                                               
 [6265] "Stage_I_Non-Small_Cell_Lung_Cancer"                                                                                                                                   
 [6266] "Stage_I_Small_Cell_Lung_Carcinoma"                                                                                                                                    
 [6267] "Stage_IA_Small_Cell_Lung_Carcinoma"                                                                                                                                   
 [6268] "Stage_IB_Small_Cell_Lung_Carcinoma"                                                                                                                                   
 [6269] "Stage_IIB_Small_Cell_Lung_Carcinoma"                                                                                                                                  
 [6270] "Stage_IIA_Small_Cell_Lung_Carcinoma"                                                                                                                                  
 [6271] "Stage_II_Small_Cell_Lung_Carcinoma"                                                                                                                                   
 [6272] "Stage_III_Small_Cell_Lung_Carcinoma"                                                                                                                                  
 [6273] "Stage_IIIA_Small_Cell_Lung_Carcinoma"                                                                                                                                 
 [6274] "Stage_IIIB_Small_Cell_Lung_Carcinoma"                                                                                                                                 
 [6275] "Stage_IV_Small_Cell_Lung_Carcinoma"                                                                                                                                   
 [6276] "Occult_Small_Cell_Lung_Carcinoma"                                                                                                                                     
 [6277] "Occult_Adenosquamous_Lung_Carcinoma"                                                                                                                                  
 [6278] "Occult_Large_Cell_Lung_Carcinoma"                                                                                                                                     
 [6279] "Occult_Squamous_Cell_Lung_Carcinoma"                                                                                                                                  
 [6280] "Stage_IA_Squamous_Cell_Lung_Carcinoma"                                                                                                                                
 [6281] "Stage_IIA_Squamous_Cell_Lung_Carcinoma"                                                                                                                               
 [6282] "Stage_IIIA_Squamous_Cell_Lung_Carcinoma"                                                                                                                              
 [6283] "Stage_IIIB_Squamous_Cell_Lung_Carcinoma"                                                                                                                              
 [6284] "Stage_IIB_Squamous_Cell_Lung_Carcinoma"                                                                                                                               
 [6285] "Stage_IB_Squamous_Cell_Lung_Carcinoma"                                                                                                                                
 [6286] "Stage_IB_Lung_Adenocarcinoma"                                                                                                                                         
 [6287] "Stage_IA_Lung_Adenocarcinoma"                                                                                                                                         
 [6288] "Stage_IIA_Lung_Adenocarcinoma"                                                                                                                                        
 [6289] "Stage_IIB_Lung_Adenocarcinoma"                                                                                                                                        
 [6290] "Stage_IIIB_Lung_Adenocarcinoma"                                                                                                                                       
 [6291] "Stage_IIIA_Lung_Adenocarcinoma"                                                                                                                                       
 [6292] "Occult_Lung_Adenocarcinoma"                                                                                                                                           
 [6293] "Pyriform_Fossa_Carcinoma"                                                                                                                                             
 [6294] "Stage_IV_Osteosarcoma"                                                                                                                                                
 [6295] "Stage_IVA_Osteosarcoma"                                                                                                                                               
 [6296] "Stage_IVB_Osteosarcoma"                                                                                                                                               
 [6297] "Stage_I_Bone_Sarcoma"                                                                                                                                                 
 [6298] "Stage_II_Bone_Sarcoma"                                                                                                                                                
 [6299] "Stage_IV_Bone_Sarcoma"                                                                                                                                                
 [6300] "Stage_IVA_Bone_Sarcoma"                                                                                                                                               
 [6301] "Stage_IVB_Bone_Sarcoma"                                                                                                                                               
 [6302] "Stage_I_Osteosarcoma"                                                                                                                                                 
 [6303] "Stage_II_Osteosarcoma"                                                                                                                                                
 [6304] "Chest_Wall_Solitary_Plasmacytoma"                                                                                                                                     
 [6305] "Chest_Wall_Lymphoma"                                                                                                                                                  
 [6306] "Chest_Wall_Fibromatosis"                                                                                                                                              
 [6307] "Sternal_Chondromyxoid_Fibroma"                                                                                                                                        
 [6308] "Sternal_Lymphoma"                                                                                                                                                     
 [6309] "Sternal_Paget_s_Disease"                                                                                                                                              
 [6310] "Sternal_Intraosseous_Schwannoma"                                                                                                                                      
 [6311] "Chest_Wall_Lipoma"                                                                                                                                                    
 [6312] "Chest_Wall_Parachordoma"                                                                                                                                              
 [6313] "Chest_Wall_Plexiform_Fibrohistiocytic_Neoplasm"                                                                                                                       
 [6314] "Chest_Wall_Ectopic_Synovial_Bursa_Cyst"                                                                                                                               
 [6315] "Chest_Wall_Hodgkin_s_Lymphoma"                                                                                                                                        
 [6316] "Malignant_Chest_Wall_Bone_Neoplasm"                                                                                                                                   
 [6317] "Hereditary_Non-Polyposis_Colon_Cancer_Type_1"                                                                                                                         
 [6318] "Hereditary_Non-Polyposis_Colon_Cancer_Type_2"                                                                                                                         
 [6319] "Neurofibromatosis"                                                                                                                                                    
 [6320] "Gardner_s_Syndrome"                                                                                                                                                   
 [6321] "Flat_Adenoma_Syndrome"                                                                                                                                                
 [6322] "Sternal_Neoplasm"                                                                                                                                                     
 [6323] "Stage_IIA_Esophageal_Adenocarcinoma"                                                                                                                                  
 [6324] "Stage_IIB_Esophageal_Adenocarcinoma"                                                                                                                                  
 [6325] "Stage_IVA_Esophageal_Adenocarcinoma"                                                                                                                                  
 [6326] "Stage_IVB_Esophageal_Adenocarcinoma"                                                                                                                                  
 [6327] "Stage_IVB_Esophageal_Squamous_Cell_Carcinoma"                                                                                                                         
 [6328] "Stage_IVA_Esophageal_Squamous_Cell_Carcinoma"                                                                                                                         
 [6329] "Stage_IIB_Esophageal_Squamous_Cell_Carcinoma"                                                                                                                         
 [6330] "Stage_IIA_Esophageal_Squamous_Cell_Carcinoma"                                                                                                                         
 [6331] "Cardiac_Rhabdomyoma"                                                                                                                                                  
 [6332] "Atrial_Septum_Lipomatous_Hypertrophy"                                                                                                                                 
 [6333] "Cardiac_Lipoma"                                                                                                                                                       
 [6334] "Epicardial_Lipoma"                                                                                                                                                    
 [6335] "Pericardial_Leiomyoma"                                                                                                                                                
 [6336] "Mature_Pericardial_Teratoma"                                                                                                                                          
 [6337] "Superior_Vena_Cava_Leiomyosarcoma"                                                                                                                                    
 [6338] "Pulmonary_Artery_Angiosarcoma"                                                                                                                                        
 [6339] "Malignant_Fibrous_Mesothelioma"                                                                                                                                       
 [6340] "Benign_Glomus_Tumor"                                                                                                                                                  
 [6341] "Palate_Kaposi_s_Sarcoma"                                                                                                                                              
 [6342] "Cutaneous_Glomangioma"                                                                                                                                                
 [6343] "Benign_Extragonadal_Germ_Cell_Neoplasm"                                                                                                                               
 [6344] "Pineal_Region_Yolk_Sac_Tumor"                                                                                                                                         
 [6345] "Pineal_Region_Teratoma"                                                                                                                                               
 [6346] "Pineal_Region_Mature_Teratoma"                                                                                                                                        
 [6347] "Pineal_Region_Immature_Teratoma"                                                                                                                                      
 [6348] "Pineal_Region_Meningioma"                                                                                                                                             
 [6349] "Benign_Central_Nervous_System_Soft_Tissue_Neoplasm"                                                                                                                   
 [6350] "Malignant_Central_Nervous_System_Soft_Tissue_Neoplasm"                                                                                                                
 [6351] "Pineal_Region_Choriocarcinoma"                                                                                                                                        
 [6352] "Breast_Small_Cell_Carcinoma"                                                                                                                                          
 [6353] "Colon_Small_Cell_Carcinoma"                                                                                                                                           
 [6354] "Esophageal_Small_Cell_Carcinoma"                                                                                                                                      
 [6355] "Gallbladder_Small_Cell_Carcinoma"                                                                                                                                     
 [6356] "Gastric_Small_Cell_Carcinoma"                                                                                                                                         
 [6357] "Prostate_Small_Cell_Carcinoma"                                                                                                                                        
 [6358] "Malignant_Pineal_Region_Germ_Cell_Neoplasm"                                                                                                                           
 [6359] "Depression_and_Suicide"                                                                                                                                               
 [6360] "Optic_Nerve_Astrocytoma"                                                                                                                                              
 [6361] "Ependymal_Tumor"                                                                                                                                                      
 [6362] "Olfactory_Groove_Meningioma"                                                                                                                                          
 [6363] "Childhood_Supratentorial_Ependymoblastoma"                                                                                                                            
 [6364] "Childhood_Infratentorial_Ependymoblastoma"                                                                                                                            
 [6365] "Recurrent_Childhood_Medulloblastoma"                                                                                                                                  
 [6366] "Posterior_Cranial_Fossa_Meningioma"                                                                                                                                   
 [6367] "Suprasellar_Meningioma"                                                                                                                                               
 [6368] "Periocular_Meningioma"                                                                                                                                                
 [6369] "Intraorbital_Meningioma"                                                                                                                                              
 [6370] "Gasserian_Meningioma"                                                                                                                                                 
 [6371] "Acidophil_Adenoma"                                                                                                                                                    
 [6372] "Stromal_Neoplasm"                                                                                                                                                     
 [6373] "Mesonephroma"                                                                                                                                                         
 [6374] "Transitional_Cell_Neoplasm"                                                                                                                                           
 [6375] "Cystic_Neoplasm"                                                                                                                                                      
 [6376] "Malignant_Eyelid_Neoplasm"                                                                                                                                            
 [6377] "Ectopic_Parathormone_Secretion"                                                                                                                                       
 [6378] "Parotid_Gland_Carcinoma"                                                                                                                                              
 [6379] "Sphenoid_Sinus_Neoplasm"                                                                                                                                              
 [6380] "Supraglottis_Neoplasm"                                                                                                                                                
 [6381] "Gastric_Cardia_Carcinoma"                                                                                                                                             
 [6382] "Gastric_Pylorus_Carcinoma"                                                                                                                                            
 [6383] "Eccrine_Neoplasm"                                                                                                                                                     
 [6384] "Benign_Eccrine_Neoplasm"                                                                                                                                              
 [6385] "Apocrine_Neoplasm"                                                                                                                                                    
 [6386] "Benign_Apocrine_Neoplasm"                                                                                                                                             
 [6387] "Malignant_Apocrine_Neoplasm"                                                                                                                                          
 [6388] "Cutaneous_Fibrous_Histiocytoma"                                                                                                                                       
 [6389] "Benign_Ovarian_Sex_Cord-Stromal_Tumor"                                                                                                                                
 [6390] "Lacrimal_Gland_Carcinoma_Ex_Pleomorphic_Adenoma"                                                                                                                      
 [6391] "Metastasis_to_Pituitary_Gland"                                                                                                                                        
 [6392] "Benign_Cutaneous_Fibrous_Neoplasm"                                                                                                                                    
 [6393] "Benign_External_Ear_Neoplasm"                                                                                                                                         
 [6394] "Dermoid_Cyst_of_the_Spinal_Cord"                                                                                                                                      
 [6395] "Cerebellar_Pilocytic_Astrocytoma"                                                                                                                                     
 [6396] "Testicular_Lymphoma"                                                                                                                                                  
 [6397] "Plantar_Verrucous_Skin_Carcinoma"                                                                                                                                     
 [6398] "Mediastinal_Seminoma"                                                                                                                                                 
 [6399] "Prostate_Ductal_Adenocarcinoma"                                                                                                                                       
 [6400] "Superficial_Fibromatosis"                                                                                                                                             
 [6401] "Spinal_Cord_Hamartoma"                                                                                                                                                
 [6402] "Low-Grade_B-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                              
 [6403] "High-Grade_B-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                             
 [6404] "Intermediate-Grade_B-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                     
 [6405] "Grade_I_Pancreatic_Intraepithelial_Neoplasia"                                                                                                                         
 [6406] "Balanced_Chromosomal_Alteration"                                                                                                                                      
 [6407] "Unbalanced_Chromosomal_Alteration"                                                                                                                                    
 [6408] "Reciprocal_Chromosomal_Translocations"                                                                                                                                
 [6409] "Numerical_Chromosome_Aberration"                                                                                                                                      
 [6410] "Structural_Chromosomal_Abnormality"                                                                                                                                   
 [6411] "Chromosomal_Inversion"                                                                                                                                                
 [6412] "Chromosomal_Insertion"                                                                                                                                                
 [6413] "Chromosomal_Duplication"                                                                                                                                              
 [6414] "Derivative_Chromosome"                                                                                                                                                
 [6415] "Isodicentric_Chromosome"                                                                                                                                              
 [6416] "Homogeneously_Staining_Region"                                                                                                                                        
 [6417] "Double_Minutes"                                                                                                                                                       
 [6418] "Middle_Ear_Adenoma"                                                                                                                                                   
 [6419] "Paranasal_Sinus_Schneiderian_Papilloma"                                                                                                                               
 [6420] "Ethmoid_Sinus_Schneiderian_Papilloma"                                                                                                                                 
 [6421] "Frontal_Sinus_Schneiderian_Papilloma"                                                                                                                                 
 [6422] "Sphenoid_Sinus_Schneiderian_Papilloma"                                                                                                                                
 [6423] "Maxillary_Sinus_Schneiderian_Papilloma"                                                                                                                               
 [6424] "Maxillary_Sinus_Inverted_Papilloma"                                                                                                                                   
 [6425] "Sphenoid_Sinus_Inverted_Papilloma"                                                                                                                                    
 [6426] "Frontal_Sinus_Inverted_Papilloma"                                                                                                                                     
 [6427] "Ethmoid_Sinus_Inverted_Papilloma"                                                                                                                                     
 [6428] "Hard_Palate_Monomorphic_Adenoma"                                                                                                                                      
 [6429] "Oral_Cavity_Monomorphic_Adenoma"                                                                                                                                      
 [6430] "Thyroid_Hyalinizing_Trabecular_Adenoma"                                                                                                                               
 [6431] "Parotid_Gland_Monomorphic_Adenoma"                                                                                                                                    
 [6432] "Middle_Ear_Adenocarcinoma"                                                                                                                                            
 [6433] "Paranasal_Sinus_Sarcoma"                                                                                                                                              
 [6434] "High_Grade_Paranasal_Sinus_Sarcoma"                                                                                                                                   
 [6435] "Low_Grade_Paranasal_Sinus_Sarcoma"                                                                                                                                    
 [6436] "Adult_Atypical_Meningioma"                                                                                                                                            
 [6437] "Kadish_Stage_A_Olfactory_Neuroblastoma"                                                                                                                               
 [6438] "Kadish_Stage_B_Olfactory_Neuroblastoma"                                                                                                                               
 [6439] "Cervical_Microglandular_Polyp"                                                                                                                                        
 [6440] "Vulvar_Fibroepithelial_Polyp"                                                                                                                                         
 [6441] "Cutaneous_B-Cell_Lymphoma"                                                                                                                                            
 [6442] "Grade_3_Cutaneous_Follicular_Lymphoma"                                                                                                                                
 [6443] "Primary_Cutaneous_Anaplastic_Large_Cell_Lymphoma"                                                                                                                     
 [6444] "Choroid_Spindle_Cell_Type_A_Melanoma"                                                                                                                                 
 [6445] "Choroid_Spindle_Cell_Type_B_Melanoma"                                                                                                                                 
 [6446] "Ciliary_Body_Spindle_Cell_Type_B_Melanoma"                                                                                                                            
 [6447] "Ciliary_Body_Spindle_Cell_Type_A_Melanoma"                                                                                                                            
 [6448] "Choroid_Necrotic_Melanoma"                                                                                                                                            
 [6449] "Myelodysplastic_Syndrome_Associated_with_Isolated_del_5q_Chromosome_Abnormality"                                                                                      
 [6450] "Stage_IV_Laryngeal_Cancer"                                                                                                                                            
 [6451] "Cystic_Hypersecretory_Breast_Carcinoma"                                                                                                                               
 [6452] "Solid_Papillary_Carcinoma_of_the_Breast"                                                                                                                              
 [6453] "Inverted_Schneiderian_Papilloma"                                                                                                                                      
 [6454] "Stage_IV_Anal_Canal_Cancer"                                                                                                                                           
 [6455] "Clear_Cell_Neoplasm"                                                                                                                                                  
 [6456] "Large_Cell_Neuroendocrine_Carcinoma"                                                                                                                                  
 [6457] "Large_Cell_Lung_Carcinoma_with_Rhabdoid_Phenotype"                                                                                                                    
 [6458] "Grade_III_Glandular_Intraepithelial_Neoplasia"                                                                                                                        
 [6459] "Mixed_Acinar-Endocrine_Carcinoma"                                                                                                                                     
 [6460] "Mixed_Ductal-Endocrine_Carcinoma"                                                                                                                                     
 [6461] "Glandular_Papilloma"                                                                                                                                                  
 [6462] "Bile_Duct_Papillomatosis"                                                                                                                                             
 [6463] "Micropapillary_Serous_Carcinoma"                                                                                                                                      
 [6464] "Pancreatic_Mucinous_Cystic_Neoplasm_with_Moderate_Dysplasia"                                                                                                          
 [6465] "Acinar_Cell_Cystadenocarcinoma"                                                                                                                                       
 [6466] "Thymoma_Type_AB"                                                                                                                                                      
 [6467] "Malignant_Type_AB_Thymoma"                                                                                                                                            
 [6468] "Thymoma_Type_B1"                                                                                                                                                      
 [6469] "Thymoma_Type_B2"                                                                                                                                                      
 [6470] "Malignant_Type_B2_Thymoma"                                                                                                                                            
 [6471] "Diffuse_Melanocytosis"                                                                                                                                                
 [6472] "Meningeal_Melanomatosis"                                                                                                                                              
 [6473] "Cellular_Fibroma"                                                                                                                                                     
 [6474] "Solitary_Fibrous_Tumor_of_the_Pleura_and_Peritoneum"                                                                                                                  
 [6475] "Malignant_Solitary_Fibrous_Tumor"                                                                                                                                     
 [6476] "Atypical_Polypoid_Adenomyoma"                                                                                                                                         
 [6477] "Benign_Cystic_Nephroma"                                                                                                                                               
 [6478] "Cystic_Partially_Differentiated_Nephroblastoma"                                                                                                                       
 [6479] "Malignant_Multilocular_Cystic_Nephroma"                                                                                                                               
 [6480] "Adenomyoepithelioma"                                                                                                                                                  
 [6481] "Epithelioid_Trophoblastic_Tumor"                                                                                                                                      
 [6482] "Central_Osteosarcoma"                                                                                                                                                 
 [6483] "Chondroid_Chordoma"                                                                                                                                                   
 [6484] "Tanycytic_Ependymoma"                                                                                                                                                 
 [6485] "Large_Cell_Medulloblastoma"                                                                                                                                           
 [6486] "Cerebellar_Liponeurocytoma"                                                                                                                                           
 [6487] "Atypical_Teratoid_Rhabdoid_Tumor"                                                                                                                                     
 [6488] "Metaplastic_Meningioma"                                                                                                                                               
 [6489] "Chordoid_Meningioma"                                                                                                                                                  
 [6490] "Rhabdoid_Meningioma"                                                                                                                                                  
 [6491] "Melanotic_Psammomatous_Malignant_Peripheral_Nerve_Sheath_Tumor"                                                                                                       
 [6492] "Intraneural_Perineurioma"                                                                                                                                             
 [6493] "Soft_Tissue_Perineurioma"                                                                                                                                             
 [6494] "Lymphocyte_Rich_Classical_Hodgkin_s_Lymphoma"                                                                                                                         
 [6495] "Hodgkin_s_Granuloma"                                                                                                                                                  
 [6496] "Primary_Effusion_Lymphoma"                                                                                                                                            
 [6497] "Anaplastic_Lymphoma"                                                                                                                                                  
 [6498] "Atypical_Burkitt_s_Burkitt_s-Like_Lymphoma"                                                                                                                           
 [6499] "Subcutaneous_Panniculitis-Like_T-Cell_Lymphoma"                                                                                                                       
 [6500] "Precursor_T_Lymphoblastic_Lymphoma"                                                                                                                                   
 [6501] "Hand-Schuller-Christian_Disease"                                                                                                                                      
 [6502] "Langerhans_Cell_Sarcoma"                                                                                                                                              
 [6503] "Acute_Bilineal_Leukemia"                                                                                                                                              
 [6504] "Acute_Myeloid_Leukemia_with_11q23_MLL_Abnormalities"                                                                                                                  
 [6505] "Anal_Margin_Squamous_Cell_Carcinoma"                                                                                                                                  
 [6506] "Stromal_Sarcoma"                                                                                                                                                      
 [6507] "Malignant_Epithelioma"                                                                                                                                                
 [6508] "Epithelioma"                                                                                                                                                          
 [6509] "Malignant_Thecoma"                                                                                                                                                    
 [6510] "Mixed_Neoplasm"                                                                                                                                                       
 [6511] "Solitary_Plasmacytoma"                                                                                                                                                
 [6512] "Middle_Ear_Polyp"                                                                                                                                                     
 [6513] "Gangliocytoma"                                                                                                                                                        
 [6514] "Spinal_Cord_Meningioma"                                                                                                                                               
 [6515] "Aggressive_Angiomyxoma"                                                                                                                                               
 [6516] "Sweat_Gland_Carcinoma"                                                                                                                                                
 [6517] "Ductal_Carcinoma_in_situ_and_Infiltrating_Lobular_Carcinoma"                                                                                                          
 [6518] "Breast_Fibrocystic_Change_Proliferative_Type"                                                                                                                         
 [6519] "Blunt_Duct_Adenosis_of_the_Breast"                                                                                                                                    
 [6520] "Simple_Adenosis_of_the_Breast"                                                                                                                                        
 [6521] "Breast_Fibrocystic_Change_Non-Proliferative_Type"                                                                                                                     
 [6522] "Atypical_Metaplasia"                                                                                                                                                  
 [6523] "Cardiac_Fibroelastic_Hamartoma"                                                                                                                                       
 [6524] "Postoperative_Spindle_Cell_Nodule"                                                                                                                                    
 [6525] "Postoperative_Spindle_Cell_Nodule_of_the_Bladder"                                                                                                                     
 [6526] "Benign_Kidney_Hemangiopericytoma"                                                                                                                                     
 [6527] "Nonanaplastic_Wilms_Tumor"                                                                                                                                            
 [6528] "Anaplastic_Wilms_Tumor"                                                                                                                                               
 [6529] "Adult_Brain_Stem_Astrocytoma"                                                                                                                                         
 [6530] "Olfactory_Neural_Neoplasm"                                                                                                                                            
 [6531] "Retinal_Neuroblastoma"                                                                                                                                                
 [6532] "Childhood_Cerebral_Ependymoblastoma"                                                                                                                                  
 [6533] "Astrocytic_Tumor"                                                                                                                                                     
 [6534] "Anaplastic_Oligoastrocytoma"                                                                                                                                          
 [6535] "Oligodendroglial_Tumor"                                                                                                                                               
 [6536] "Chordoid_Glioma_of_the_Third_Ventricle"                                                                                                                               
 [6537] "Paraganglioma_of_the_Filum_Terminale"                                                                                                                                 
 [6538] "Neuroblastic_Tumor"                                                                                                                                                   
 [6539] "Neuroblastomas_of_the_Adrenal_Gland_and_Sympathetic_Nervous_System"                                                                                                   
 [6540] "Pineal_Parenchymal_Cell_Neoplasm"                                                                                                                                     
 [6541] "Pineocytoma"                                                                                                                                                          
 [6542] "Pineal_Parenchymal_Tumor_of_Intermediate_Differentiation"                                                                                                             
 [6543] "Supratentorial_Primitive_Neuroectodermal_Tumor"                                                                                                                       
 [6544] "Plexiform_Schwannoma"                                                                                                                                                 
 [6545] "Melanocytic_Schwannoma"                                                                                                                                               
 [6546] "Meningothelial_Cell_Neoplasm"                                                                                                                                         
 [6547] "Mesenchymal_Non-Meningothelial_Tumor_of_the_Central_Nervous_System"                                                                                                   
 [6548] "Intracranial_Liposarcoma"                                                                                                                                             
 [6549] "Neoplasm_of_Uncertain_Histogenesis"                                                                                                                                   
 [6550] "Papillary_Renal_Cell_Carcinoma"                                                                                                                                       
 [6551] "Breast_Papilloma"                                                                                                                                                     
 [6552] "Breast_Papillomatosis"                                                                                                                                                
 [6553] "Squamous_Cell_Carcinoma_of_the_Penis_Usual_Type"                                                                                                                      
 [6554] "Basaloid_Carcinoma_of_the_Penis"                                                                                                                                      
 [6555] "Warty_Carcinoma_of_the_Penis"                                                                                                                                         
 [6556] "Verrucous_Carcinoma_of_the_Penis"                                                                                                                                     
 [6557] "Papillary_Carcinoma_of_the_Penis"                                                                                                                                     
 [6558] "Sarcomatoid_Carcinoma_of_the_Penis"                                                                                                                                   
 [6559] "Invasive_Hydatidiform_Mole"                                                                                                                                           
 [6560] "Breast_Myoepithelioma"                                                                                                                                                
 [6561] "Ductal_Breast_Carcinoma_with_Squamous_Metaplasia"                                                                                                                     
 [6562] "Oligoastrocytoma"                                                                                                                                                     
 [6563] "Subependymal_Astrocytoma"                                                                                                                                             
 [6564] "Embryonal_Neoplasm_of_the_CNS"                                                                                                                                        
 [6565] "Simple_Endometrial_Hyperplasia_with_Atypia"                                                                                                                           
 [6566] "Simple_Endometrial_Hyperplasia_without_Atypia"                                                                                                                        
 [6567] "Complex_Endometrial_Hyperplasia_without_Atypia"                                                                                                                       
 [6568] "Oculomotor_Nerve_Neoplasm"                                                                                                                                            
 [6569] "Malignant_Oculomotor_Nerve_Neoplasm"                                                                                                                                  
 [6570] "Uterine_Adenomyosis"                                                                                                                                                  
 [6571] "Hibernoma_of_the_Nervous_System"                                                                                                                                      
 [6572] "Leiomyoma_of_the_Central_Nervous_System"                                                                                                                              
 [6573] "Leiomyosarcoma_of_the_Central_Nervous_System"                                                                                                                         
 [6574] "Rhabdomyoma_of_the_Central_Nervous_System"                                                                                                                            
 [6575] "Chondroma_of_the_Central_Nervous_System"                                                                                                                              
 [6576] "Osteosarcoma_of_the_Central_Nervous_System"                                                                                                                           
 [6577] "Osteochondroma_of_the_Central_Nervous_System"                                                                                                                         
 [6578] "Hemangioma_of_the_Central_Nervous_System"                                                                                                                             
 [6579] "Hemangiopericytoma_of_the_Central_Nervous_System"                                                                                                                     
 [6580] "Kaposi_Sarcoma_of_the_Central_Nervous_System"                                                                                                                         
 [6581] "Hemangioblastoma_of_the_Central_Nervous_System"                                                                                                                       
 [6582] "Intracranial_Myeloid_Sarcoma"                                                                                                                                         
 [6583] "Germinoma_of_the_Central_Nervous_System"                                                                                                                              
 [6584] "Embryonal_Carcinoma_of_the_CNS"                                                                                                                                       
 [6585] "Yolk_Sac_Tumor_of_the_CNS"                                                                                                                                            
 [6586] "Central_Nervous_System_Choriocarcinoma"                                                                                                                               
 [6587] "Central_Nervous_System_Mature_Teratoma"                                                                                                                               
 [6588] "Central_Nervous_System_Immature_Teratoma"                                                                                                                             
 [6589] "Teratoma_of_the_CNS_with_Malignant_Transformation"                                                                                                                    
 [6590] "Mixed_Germ_Cell_Neoplasms_of_the_Central_Nervous_System"                                                                                                              
 [6591] "Granular_Cell_Tumor_of_the_Neurohypophysis"                                                                                                                           
 [6592] "Neurothekeoma"                                                                                                                                                        
 [6593] "Trilateral_Retinoblastoma"                                                                                                                                            
 [6594] "Inflammatory_Pseudotumor_Intracranial"                                                                                                                                
 [6595] "Intracranial_Plasma_Cell_Granuloma"                                                                                                                                   
 [6596] "Gastric_Inflammatory_Myofibroblastic_Tumor"                                                                                                                           
 [6597] "Refractory_Plasma_Cell_Myeloma"                                                                                                                                       
 [6598] "Recurrent_Plasma_Cell_Myeloma"                                                                                                                                        
 [6599] "Barrett_s_Adenocarcinoma"                                                                                                                                             
 [6600] "Gastric_Heterotopia_of_the_Small_Intestine"                                                                                                                           
 [6601] "Gastric_Heterotopia_of_the_Large_Intestine"                                                                                                                           
 [6602] "Adenocarcinoid_Tumor_of_the_Appendix"                                                                                                                                 
 [6603] "Esophageal_Basaloid_Squamous_Cell_Carcinoma"                                                                                                                          
 [6604] "Gastric_Hyperplastic_Polyp"                                                                                                                                           
 [6605] "Gastric_Juvenile_Polyp"                                                                                                                                               
 [6606] "Gastric_Cronkhite_Canada_Polyposis"                                                                                                                                   
 [6607] "Gastric_Tubular_Adenoma"                                                                                                                                              
 [6608] "Gastric_Tubulovillous_Adenoma"                                                                                                                                        
 [6609] "Gastric_Villous_Adenoma"                                                                                                                                              
 [6610] "Gallbladder_Pancreatic_Heterotopia"                                                                                                                                   
 [6611] "Central_Nervous_System_Neoplasms_by_Morphology"                                                                                                                       
 [6612] "Colon_Tubular_Adenoma"                                                                                                                                                
 [6613] "Colon_Ganglioneuroma"                                                                                                                                                 
 [6614] "Intracranial_Central_Nervous_System_Neoplasms_by_Morphology"                                                                                                          
 [6615] "Malignant_Intracranial_Neoplasms_By_Morphology"                                                                                                                       
 [6616] "Urogenital_System_Paraganglioma"                                                                                                                                      
 [6617] "Functioning_Pituitary_Gland_Neoplasm"                                                                                                                                 
 [6618] "Supratentorial_Meningioma"                                                                                                                                            
 [6619] "Adult_Astrocytic_Tumor"                                                                                                                                               
 [6620] "Meningioma_by_Morphology"                                                                                                                                             
 [6621] "Meningioma_by_Site"                                                                                                                                                   
 [6622] "Solitary_Myofibromatosis"                                                                                                                                             
 [6623] "Cavernous_Hemangioma_of_the_Face"                                                                                                                                     
 [6624] "Childhood_Lymphocyte_Rich_Classical_Hodgkin_s_Lymphoma"                                                                                                               
 [6625] "Precursor_Lymphoblastic_Leukemia_Lymphoma"                                                                                                                            
 [6626] "Mature_B-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                                 
 [6627] "Diseases_Disorders_and_Findings"                                                                                                                                      
 [6628] "Melanocytic_Neoplasm"                                                                                                                                                 
 [6629] "Mesenchymal_Cell_Neoplasm"                                                                                                                                            
 [6630] "Neural_Cell_Neoplasm"                                                                                                                                                 
 [6631] "Retinal_Cell_Neoplasm"                                                                                                                                                
 [6632] "Neoplasm_by_Special_Category"                                                                                                                                         
 [6633] "Notochordal_Neoplasm"                                                                                                                                                 
 [6634] "Erythroid_Neoplasm"                                                                                                                                                   
 [6635] "Lymphocytic_Neoplasm"                                                                                                                                                 
 [6636] "Megakaryocytic_Neoplasm"                                                                                                                                              
 [6637] "Neoplastic_Polyp"                                                                                                                                                     
 [6638] "Giant_Cell_Neoplasm"                                                                                                                                                  
 [6639] "Mucinous_Neoplasm"                                                                                                                                                    
 [6640] "Myoepithelioma"                                                                                                                                                       
 [6641] "Oncocytic_Neoplasm"                                                                                                                                                   
 [6642] "Paget_s_Cell_Neoplasm"                                                                                                                                                
 [6643] "Serous_Neoplasm"                                                                                                                                                      
 [6644] "Fibrocytic_Neoplasm"                                                                                                                                                  
 [6645] "Hemangiopericytic_Neoplasm"                                                                                                                                           
 [6646] "Common_Neoplasm"                                                                                                                                                      
 [6647] "Neoplasm_by_Morphologic_Variation_and_Secondary_Features"                                                                                                             
 [6648] "Prostate_Cancer_by_Whitmore-Jewett_Stage"                                                                                                                             
 [6649] "Metastatic_Neoplasm_to_the_Prostate"                                                                                                                                  
 [6650] "Colorectal_Cancer_by_Astler-Coller_Stage"                                                                                                                             
 [6651] "Colon_Cancer_by_Astler-Coller_Stage"                                                                                                                                  
 [6652] "Rectal_Cancer_by_Astler-Coller_Stage"                                                                                                                                 
 [6653] "Small_Intestine_Leiomyosarcoma"                                                                                                                                       
 [6654] "Recurrent_Melanoma"                                                                                                                                                   
 [6655] "Recurrent_Non-Cutaneous_Melanoma"                                                                                                                                     
 [6656] "Regressing_Melanoma_of_the_Skin"                                                                                                                                      
 [6657] "Regressing_Non-Cutaneous_Melanoma"                                                                                                                                    
 [6658] "Gastrointestinal_Melanoma"                                                                                                                                            
 [6659] "Metastatic_Non-Cutaneous_Melanoma"                                                                                                                                    
 [6660] "Hepatoblastoma_with_Pure_Fetal_Epithelial_Differentiation"                                                                                                            
 [6661] "Hepatoblastoma_with_Combined_Fetal_Epithelial_Differentiation"                                                                                                        
 [6662] "Macrotrabecular_Hepatoblastoma"                                                                                                                                       
 [6663] "Small_Cell_Undifferentiated_Hepatoblastoma"                                                                                                                           
 [6664] "Mixed_Epithelial_and_Mesenchymal_Hepatoblastoma"                                                                                                                      
 [6665] "Mixed_Hepatoblastoma_with_Teratoid_Features"                                                                                                                          
 [6666] "Stage_D_Prostate_Cancer"                                                                                                                                              
 [6667] "Undifferentiated_Colon_Carcinoma"                                                                                                                                     
 [6668] "Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm"                                                                                                                          
 [6669] "Mature_Mediastinal_Teratoma"                                                                                                                                          
 [6670] "Exaggerated_Placental_Site"                                                                                                                                           
 [6671] "Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm"                                                                                                               
 [6672] "Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm"                                                                                                           
 [6673] "Distal_Biliary_Tract_Carcinoma"                                                                                                                                       
 [6674] "Recurrent_Liver_Cancer"                                                                                                                                               
 [6675] "Benign_Ameloblastoma"                                                                                                                                                 
 [6676] "Squamous_Odontogenic_Tumor"                                                                                                                                           
 [6677] "Endometrioid_Tumor"                                                                                                                                                   
 [6678] "Thymoma_Type_B"                                                                                                                                                       
 [6679] "Malignant_Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm"                                                                                                 
 [6680] "Stage_I_Liver_Cancer"                                                                                                                                                 
 [6681] "Stage_II_Liver_Cancer"                                                                                                                                                
 [6682] "Stage_III_Liver_Cancer"                                                                                                                                               
 [6683] "Stage_IIIA_Liver_Cancer"                                                                                                                                              
 [6684] "Stage_IIIB_Liver_Cancer"                                                                                                                                              
 [6685] "Stage_IV_Liver_Cancer"                                                                                                                                                
 [6686] "Stage_IVA_Liver_Cancer"                                                                                                                                               
 [6687] "Stage_IVB_Liver_Cancer"                                                                                                                                               
 [6688] "Extrahepatic_Bile_Duct_Papillomatosis"                                                                                                                                
 [6689] "Intrahepatic_Bile_Duct_Papillomatosis"                                                                                                                                
 [6690] "Intrahepatic_Bile_Duct_Adenoma"                                                                                                                                       
 [6691] "Intrahepatic_Bile_Duct_Cystadenoma"                                                                                                                                   
 [6692] "Benign_Extrahepatic_Bile_Duct_Non-Epithelial_Neoplasm"                                                                                                                
 [6693] "Benign_Non-Epithelial_Gallbladder_Neoplasm"                                                                                                                           
 [6694] "Gallbladder_Papillomatosis"                                                                                                                                           
 [6695] "Benign_Gallbladder_Granular_Cell_Tumor"                                                                                                                               
 [6696] "Glandular_Cell_Neoplasm"                                                                                                                                              
 [6697] "Tubular_Androblastoma-Sertoli_Cell_Tumor"                                                                                                                             
 [6698] "Bone_Surface_Peripheral_Osteosarcoma"                                                                                                                                 
 [6699] "Extraosseous_Ewing_s_Sarcoma"                                                                                                                                         
 [6700] "Extracutaneous_Mastocytoma"                                                                                                                                           
 [6701] "Cutaneous_Mastocytosis"                                                                                                                                               
 [6702] "Solitary_Mastocytoma_of_the_Skin"                                                                                                                                     
 [6703] "PRETEXT_Stage_1_Hepatoblastoma"                                                                                                                                       
 [6704] "PRETEXT_Stage_2_Hepatoblastoma"                                                                                                                                       
 [6705] "PRETEXT_Stage_3_Hepatoblastoma"                                                                                                                                       
 [6706] "PRETEXT_Stage_4_Hepatoblastoma"                                                                                                                                       
 [6707] "Postsurgical_Stage_IV_Hepatoblastoma"                                                                                                                                 
 [6708] "Postsurgical_Stage_III_Hepatoblastoma"                                                                                                                                
 [6709] "Postsurgical_Stage_II_Hepatoblastoma"                                                                                                                                 
 [6710] "Postsurgical_Stage_I_Hepatoblastoma"                                                                                                                                  
 [6711] "Benign_Fibrous_Soft_Tissue_Neoplasm"                                                                                                                                  
 [6712] "Miscellaneous_Mesenchymal_Neoplasm"                                                                                                                                   
 [6713] "Smoldering_Myeloma"                                                                                                                                                   
 [6714] "Indolent_Myeloma"                                                                                                                                                     
 [6715] "Monoclonal_Immunoglobulin_Deposition_Disease"                                                                                                                         
 [6716] "Erythroleukemia"                                                                                                                                                      
 [6717] "Well-differentiated_Thyroid_Carcinoma"                                                                                                                                
 [6718] "Bone_Leiomyosarcoma"                                                                                                                                                  
 [6719] "Primary_Bone_Chondrosarcoma"                                                                                                                                          
 [6720] "Neurohypophysis_Neoplasm"                                                                                                                                             
 [6721] "Benign_Dermal_Neoplasm"                                                                                                                                               
 [6722] "Subepidermal_Nodular_Fibrosis"                                                                                                                                        
 [6723] "Sclerosing_Hemangioma"                                                                                                                                                
 [6724] "Melanocytic_Skin_Neoplasm"                                                                                                                                            
 [6725] "Cutaneous_Lymphoma"                                                                                                                                                   
 [6726] "Classical_Hodgkin_s_Lymphoma"                                                                                                                                         
 [6727] "Grade_1_Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                                         
 [6728] "Grade_2_Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                                         
 [6729] "RAEB-1"                                                                                                                                                               
 [6730] "RAEB-2"                                                                                                                                                               
 [6731] "Pineal_Region_Dysgerminoma"                                                                                                                                           
 [6732] "Acute_Monocytic_Leukemia"                                                                                                                                             
 [6733] "Acute_Monoblastic_Leukemia"                                                                                                                                           
 [6734] "Central_Nervous_System_Neuroepithelial_Neoplasm_of_Uncertain_Origin"                                                                                                  
 [6735] "Diffuse_Astrocytoma"                                                                                                                                                  
 [6736] "Adult_Diffuse_Astrocytoma"                                                                                                                                            
 [6737] "Acute_Myeloid_Leukemia_with_Recurrent_Genetic_Abnormalities"                                                                                                          
 [6738] "Aleukemic_Lymphocytic_Leukemia"                                                                                                                                       
 [6739] "Aleukemic_Lymphoblastic_Leukemia"                                                                                                                                     
 [6740] "Smoldering_Adult_T-Cell_Lymphoma_Leukemia"                                                                                                                            
 [6741] "Chronic_Adult_T-Cell_Lymphoma_Leukemia"                                                                                                                               
 [6742] "Spindle_Cell_Pleomorphic_Lipoma"                                                                                                                                      
 [6743] "B-Cell_Proliferation_of_Uncertain_Malignant_Potential"                                                                                                                
 [6744] "Polymorphic_Post-Transplant_Lymphoproliferative_Disorder"                                                                                                             
 [6745] "Methotrexate-Associated_Lymphoproliferative_Disorder"                                                                                                                 
 [6746] "Lymphoma_by_Site"                                                                                                                                                     
 [6747] "Lymphoma_by_Working_Formulation_Antiquated"                                                                                                                           
 [6748] "Non-Burkitt_s_Lymphoma"                                                                                                                                               
 [6749] "Classical_Burkitt_s_Lymphoma"                                                                                                                                         
 [6750] "Burkitt_s_Lymphoma_with_Plasmacytoid_Differentiation"                                                                                                                 
 [6751] "Malignant_Hypopharyngeal_Neoplasm"                                                                                                                                    
 [6752] "Grade_3a_Follicular_Lymphoma"                                                                                                                                         
 [6753] "Grade_3b_Follicular_Lymphoma"                                                                                                                                         
 [6754] "Grade_2_Diffuse_Follicle_Center_Lymphoma"                                                                                                                             
 [6755] "Primary_Cutaneous_CD30-Positive_T-Cell_Lymphoproliferative_Disorder"                                                                                                  
 [6756] "Borderline_Primary_Cutaneous_CD30-Positive_T-Cell_Lymphoproliferative_Disorder"                                                                                       
 [6757] "Type_A_Lymphomatoid_Papulosis"                                                                                                                                        
 [6758] "Type_B_Lymphomatoid_Papulosis"                                                                                                                                        
 [6759] "Diffuse_Large_Cell_Type_Lymphomatoid_Papulosis"                                                                                                                       
 [6760] "Anaplastic_Large_Cell_Lymphoma_Lymphomatoid_Papulosis-Like_Histology"                                                                                                 
 [6761] "Infrequent_Neoplasm"                                                                                                                                                  
 [6762] "Malignant_Histiocytosis"                                                                                                                                              
 [6763] "Blastic_NK-Cell_Lymphoma"                                                                                                                                             
 [6764] "T-Zone_Variant_Peripheral_T-Cell_Lymphoma"                                                                                                                            
 [6765] "Lymphoepithelioid_Cell_Variant_Peripheral_T-Cell_Lymphoma"                                                                                                            
 [6766] "Common_Variant_Anaplastic_Large_Cell_Lymphoma"                                                                                                                        
 [6767] "Lymphohistiocytic_Variant_Anaplastic_Large_Cell_Lymphoma"                                                                                                             
 [6768] "Small_Cell_Variant_Anaplastic_Large_Cell_Lymphoma"                                                                                                                    
 [6769] "Childhood_Precursor_B_Lymphoblastic_Lymphoma"                                                                                                                         
 [6770] "Childhood_Precursor_T_Lymphoblastic_Lymphoma"                                                                                                                         
 [6771] "Childhood_Primary_Cutaneous_Anaplastic_Large_Cell_Lymphoma"                                                                                                           
 [6772] "AIDS-Related_Diffuse_Large_B-cell_Lymphoma"                                                                                                                           
 [6773] "AIDS-Related_Diffuse_Large_Cell_Lymphoma"                                                                                                                             
 [6774] "Non-Hodgkin_s_Lymphoma_by_Clinical_Course"                                                                                                                            
 [6775] "Non-Hodgkin_s_Lymphoma_with_Variable_Clinical_Course"                                                                                                                 
 [6776] "Cutaneous_Follicle_Center_Lymphoma"                                                                                                                                   
 [6777] "Cutaneous_Follicular_Lymphoma"                                                                                                                                        
 [6778] "Grade_2_Cutaneous_Follicular_Lymphoma"                                                                                                                                
 [6779] "Grade_1_Cutaneous_Follicular_Lymphoma"                                                                                                                                
 [6780] "Cutaneous_Hodgkin_s_Lymphoma"                                                                                                                                         
 [6781] "Hematopoietic_and_Lymphoid_Neoplasms_NEC"                                                                                                                             
 [6782] "Adult_Lymphocyte_Rich_Classical_Hodgkin_s_Lymphoma"                                                                                                                   
 [6783] "Plasmablastic_Lymphoma"                                                                                                                                               
 [6784] "Diffuse_Large_B-Cell_Lymphoma_with_Expression_of_Full-Length_ALK"                                                                                                     
 [6785] "Adult_Precursor_T_Lymphoblastic_Lymphoma"                                                                                                                             
 [6786] "Refractory_Precursor_T_Lymphoblastic_Lymphoma"                                                                                                                        
 [6787] "Refractory_Mature_B-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                      
 [6788] "Blastoid_Variant_Mantle_Cell_Lymphoma"                                                                                                                                
 [6789] "Cutaneous_Marginal_Zone_B_Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue"                                                                                         
 [6790] "Small_Intestinal_Non-Hodgkin_s_Lymphoma"                                                                                                                              
 [6791] "Neoplastic_Post-Transplant_Lymphoproliferative_Disorder"                                                                                                              
 [6792] "Monomorphic_Post-Transplant_Lymphoproliferative_Disorder"                                                                                                             
 [6793] "Non-Neoplastic_Post-Transplant_Lymphoproliferative_Disorder"                                                                                                          
 [6794] "Plasmacytic_Hyperplasia_PTLD"                                                                                                                                         
 [6795] "Infectious-Mononucleosis-Like_PTLD"                                                                                                                                   
 [6796] "Monomorphic_B-Cell_PTLD"                                                                                                                                              
 [6797] "Monomorphic_T-Cell_PTLD"                                                                                                                                              
 [6798] "Hodgkin_s-Like_PTLD"                                                                                                                                                  
 [6799] "Plasma_Cell_PTLD"                                                                                                                                                     
 [6800] "Plasmacytoma-Like_PTLD"                                                                                                                                               
 [6801] "Plasma_Cell_Myeloma_PTLD"                                                                                                                                             
 [6802] "Hodgkin_s_Lymphoma_PTLD"                                                                                                                                              
 [6803] "Burkitt_s_Lymphoma_PTLD"                                                                                                                                              
 [6804] "Burkitt_s-Like_Lymphoma_PTLD"                                                                                                                                         
 [6805] "Diffuse_Large_B-Cell_Lymphoma_PTLD"                                                                                                                                   
 [6806] "Anaplastic_Lymphoma_PTLD"                                                                                                                                             
 [6807] "Centroblastic_Lymphoma_PTLD"                                                                                                                                          
 [6808] "Immunoblastic_Lymphoma_PTLD"                                                                                                                                          
 [6809] "Malignant_Testicular_Neoplasm"                                                                                                                                        
 [6810] "Methotrexate-Associated_Peripheral_T-Cell_Lymphoma"                                                                                                                   
 [6811] "Methotrexate-Associated_Diffuse_Large_B-Cell_Lymphoma"                                                                                                                
 [6812] "Methotrexate-Associated_Follicular_Lymphoma"                                                                                                                          
 [6813] "Methotrexate-Associated_Burkitt_s_Lymphoma"                                                                                                                           
 [6814] "Methotrexate-Associated_Hodgkin_s_Lymphoma"                                                                                                                           
 [6815] "Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma"                                                                                                                    
 [6816] "Recurrent_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma"                                                                                                          
 [6817] "Refractory_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma"                                                                                                         
 [6818] "Stage_IV_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma"                                                                                                           
 [6819] "Stage_III_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma"                                                                                                          
 [6820] "Thyroid_Immunoblastic_Lymphoma"                                                                                                                                       
 [6821] "Diffuse_Follicle_Center_Lymphoma"                                                                                                                                     
 [6822] "Angioimmunoblastic_Lymphadenopathy"                                                                                                                                   
 [6823] "Basaloid_Lung_Carcinoma"                                                                                                                                              
 [6824] "Combined_Large_Cell_Neuroendocrine_Carcinoma_of_the_Lung"                                                                                                             
 [6825] "Mucinous_Bronchiolo-Alveolar_Lung_Carcinoma"                                                                                                                          
 [6826] "Non-Mucinous_Bronchiolo-Alveolar_Lung_Carcinoma"                                                                                                                      
 [6827] "Mixed_Mucinous_and_Non-Mucinous_Bronchiolo-Alveolar_Lung_Carcinoma"                                                                                                   
 [6828] "Borderline_Ovarian_Serous_Cystic_Tumor"                                                                                                                               
 [6829] "Ovarian_Papillary_Cystadenoma"                                                                                                                                        
 [6830] "Ovarian_Surface_Papilloma"                                                                                                                                            
 [6831] "Ovarian_Transitional_Cell_Neoplasm"                                                                                                                                   
 [6832] "Borderline_Ovarian_Mixed_Epithelial_Neoplasm"                                                                                                                         
 [6833] "Benign_Ovarian_Mixed_Epithelial_Neoplasm"                                                                                                                             
 [6834] "Ovarian_Cystic_Teratoma"                                                                                                                                              
 [6835] "Ovarian_Dermoid_Cyst_with_Secondary_Tumor"                                                                                                                            
 [6836] "Ovarian_Solid_Teratoma"                                                                                                                                               
 [6837] "Ovarian_Monodermal_Teratoma"                                                                                                                                          
 [6838] "Ovarian_Granulosa-Stromal_Cell_Tumor"                                                                                                                                 
 [6839] "Adult_Type_Ovarian_Granulosa_Cell_Tumor"                                                                                                                              
 [6840] "Juvenile_Type_Ovarian_Granulosa_Cell_Tumor"                                                                                                                           
 [6841] "Thecoma-Fibroma_Group_Ovarian_Tumor"                                                                                                                                  
 [6842] "Ovarian_Cellular_Fibroma"                                                                                                                                             
 [6843] "Malignant_Splenic_Soft_Tissue_Tumor"                                                                                                                                  
 [6844] "Splenic_Non-Hodgkin_s_Lymphoma"                                                                                                                                       
 [6845] "Splenic_Hodgkin_s_Lymphoma"                                                                                                                                           
 [6846] "Splenic_Manifestation_of_Leukemia"                                                                                                                                    
 [6847] "Splenic_Manifestation_of_Prolymphocytic_Leukemia"                                                                                                                     
 [6848] "Splenic_Manifestation_of_T-Cell_Prolymphocytic_Leukemia"                                                                                                              
 [6849] "Splenic_Manifestation_of_B-Cell_Prolymphocytic_Leukemia"                                                                                                              
 [6850] "Splenic_Manifestation_of_Chronic_Lymphocytic_Leukemia"                                                                                                                
 [6851] "Splenic_Manifestation_of_Hairy_Cell_Leukemia"                                                                                                                         
 [6852] "Splenic_Manifestation_of_T-Cell_Large_Granular_Lymphocyte_Leukemia"                                                                                                   
 [6853] "Splenic_Manifestation_of_Chronic_Myelogenous_Leukemia"                                                                                                                
 [6854] "Splenic_Small_Lymphocytic_Lymphoma"                                                                                                                                   
 [6855] "Splenic_Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia"                                                                                                   
 [6856] "Splenic_Mantle_Cell_Lymphoma"                                                                                                                                         
 [6857] "Splenic_Follicular_Lymphoma"                                                                                                                                          
 [6858] "Splenic_Diffuse_Large_B-Cell_Lymphoma"                                                                                                                                
 [6859] "Splenic_Burkitt_s_Lymphoma"                                                                                                                                           
 [6860] "Splenic_Precursor_B_Lymphoblastic_Lymphoma"                                                                                                                           
 [6861] "Splenic_Precursor_T_Lymphoblastic_Lymphoma"                                                                                                                           
 [6862] "Splenic_Precursor_Lymphoblastic_Lymphoma"                                                                                                                             
 [6863] "Benign_Ovarian_Serous_Neoplasm"                                                                                                                                       
 [6864] "Borderline_Ovarian_Serous_Papillary_Neoplasm"                                                                                                                         
 [6865] "Ovarian_Mullerian_Adenosarcoma"                                                                                                                                       
 [6866] "Acute_Monoblastic_Leukemia_and_Acute_Monocytic_Leukemia"                                                                                                              
 [6867] "Adult_Acute_Monoblastic_Leukemia_and_Acute_Monocytic_Leukemia"                                                                                                        
 [6868] "Childhood_Chronic_Myelogenous_Leukemia"                                                                                                                               
 [6869] "Ovarian_Mixed_Germ_Cell-Sex_Cord-Stromal_Tumor"                                                                                                                       
 [6870] "Testicular_Mixed_Germ_Cell-Sex_Cord-Stromal_Tumor"                                                                                                                    
 [6871] "Stage_0_Seminoma"                                                                                                                                                     
 [6872] "Stage_0_Testicular_Embryonal_Carcinoma"                                                                                                                               
 [6873] "Testicular_Intratubular_Germ_Cell_Neoplasia_with_Extratubular_Extension"                                                                                              
 [6874] "Extragonadal_Seminoma"                                                                                                                                                
 [6875] "Testicular_Seminoma"                                                                                                                                                  
 [6876] "Stage_0_Testicular_Seminoma"                                                                                                                                          
 [6877] "Stage_I_Seminoma"                                                                                                                                                     
 [6878] "Stage_II_Seminoma"                                                                                                                                                    
 [6879] "Stage_III_Seminoma"                                                                                                                                                   
 [6880] "Intermediate_Fibrocytic_Neoplasm"                                                                                                                                     
 [6881] "Intermediate_Vascular_Neoplasm"                                                                                                                                       
 [6882] "Reproductive_Endocrine_Neoplasm"                                                                                                                                      
 [6883] "Nasal_Cavity_and_Paranasal_Sinus_Neoplasm"                                                                                                                            
 [6884] "Peritoneal_and_Retroperitoneal_Neoplasms"                                                                                                                             
 [6885] "Adult_Precursor_B_Lymphoblastic_Lymphoma"                                                                                                                             
 [6886] "Heavy_Chain_Deposition_Disease"                                                                                                                                       
 [6887] "Hematopoietic_and_Lymphoid_Neoplasms_Antiquated"                                                                                                                      
 [6888] "Benign_Epithelial_Skin_Neoplasm"                                                                                                                                      
 [6889] "Epithelial_Skin_Neoplasm"                                                                                                                                             
 [6890] "Benign_Cutaneous_Fibrohistiocytic_Neoplasm"                                                                                                                           
 [6891] "Intermediate_Cutaneous_Fibrohistiocytic_Neoplasm"                                                                                                                     
 [6892] "Cervical_Squamous_Intraepithelial_Neoplasia"                                                                                                                          
 [6893] "Cervical_Squamous_Cell_Carcinoma_in_situ"                                                                                                                             
 [6894] "High_Grade_Intraepithelial_Neoplasia"                                                                                                                                 
 [6895] "Grade_II_Squamous_Intraepithelial_Neoplasia"                                                                                                                          
 [6896] "Retroperitoneal_Carcinoma"                                                                                                                                            
 [6897] "Retroperitoneal_Lymphoma"                                                                                                                                             
 [6898] "Benign_Peritoneal_Mesothelioma"                                                                                                                                       
 [6899] "Renal_Pelvis_Transitional_Cell_Carcinoma"                                                                                                                             
 [6900] "Gallbladder_Adenosquamous_Carcinoma"                                                                                                                                  
 [6901] "Periosteal_Chondrosarcoma"                                                                                                                                            
 [6902] "Juxtacortical_Chondrosarcoma"                                                                                                                                         
 [6903] "Endometrial_Adenocarcinoma"                                                                                                                                           
 [6904] "Grade_II_Prostatic_Intraepithelial_Neoplasia"                                                                                                                         
 [6905] "Scrotal_Melanoma"                                                                                                                                                     
 [6906] "Scirrhous_Carcinoma_of_the_Breast"                                                                                                                                    
 [6907] "Intraductal_Papillomatosis"                                                                                                                                           
 [6908] "Diffuse_Intraductal_Papillomatosis"                                                                                                                                   
 [6909] "Focal_Intraductal_Papillomatosis"                                                                                                                                     
 [6910] "Hair_Follicle_Neoplasm"                                                                                                                                               
 [6911] "Pilomatricoma"                                                                                                                                                        
 [6912] "Paraurethral_Gland_Carcinoma"                                                                                                                                         
 [6913] "Cerebellar_Neuronal_and_Mixed_Neuronal-Glial_Tumor"                                                                                                                   
 [6914] "Nasopharyngeal_Nonkeratinizing_Carcinoma"                                                                                                                             
 [6915] "Uterine_Gestational_Choriocarcinoma"                                                                                                                                  
 [6916] "Pericardial_Fibroma"                                                                                                                                                  
 [6917] "Malignant_Pleural_Mesothelioma"                                                                                                                                       
 [6918] "Malignant_Lung_Neoplasm"                                                                                                                                              
 [6919] "Malignant_Prostate_Neoplasm"                                                                                                                                          
 [6920] "Malignant_Anal_Neoplasm"                                                                                                                                              
 [6921] "Papillary_and_Follicular_Adenocarcinoma"                                                                                                                              
 [6922] "Follicular_Variant_Papillary_Carcinoma"                                                                                                                               
 [6923] "Testicular_Polyembryoma"                                                                                                                                              
 [6924] "Papillary_Urothelial_Carcinoma"                                                                                                                                       
 [6925] "Trabecular_Follicular_Adenocarcinoma"                                                                                                                                 
 [6926] "Encapsulated_Thymoma"                                                                                                                                                 
 [6927] "Blood_Vessel_Neoplasm"                                                                                                                                                
 [6928] "Vascular_Neoplasm"                                                                                                                                                    
 [6929] "Benign_Vascular_Neoplasm"                                                                                                                                             
 [6930] "Malignant_Vascular_Neoplasm"                                                                                                                                          
 [6931] "Intermediate_Blood_Vessel_Neoplasm"                                                                                                                                   
 [6932] "Unresolved_Disease_NEC"                                                                                                                                               
 [6933] "Skin_Epithelioid_Hemangioma"                                                                                                                                          
 [6934] "Cellular_Hemangioma_of_Infancy_Strawberry_Nevus"                                                                                                                      
 [6935] "Stage_I_Nasopharyngeal_Carcinoma"                                                                                                                                     
 [6936] "Stage_III_Nasopharyngeal_Carcinoma"                                                                                                                                   
 [6937] "Stage_IV_Nasopharyngeal_Carcinoma"                                                                                                                                    
 [6938] "Malignant_Oropharyngeal_Neoplasm"                                                                                                                                     
 [6939] "Villous_Adenoma"                                                                                                                                                      
 [6940] "Burkitt_s_Cell_Leukemia"                                                                                                                                              
 [6941] "Hairy_Cell_Leukemia_Variant"                                                                                                                                          
 [6942] "Hairy_Cell_Leukemia"                                                                                                                                                  
 [6943] "Malignant_Tonsillar_Neoplasm"                                                                                                                                         
 [6944] "Chronic_Atrophic_Gastritis"                                                                                                                                           
 [6945] "Oral_Lichen_Planus"                                                                                                                                                   
 [6946] "Anal_Precancerous_Condition"                                                                                                                                          
 [6947] "Anal_Margin_Bowen_s_Disease"                                                                                                                                          
 [6948] "Anal_Margin_Squamous_Dysplasia"                                                                                                                                       
 [6949] "Malignant_Vaginal_Neoplasm"                                                                                                                                           
 [6950] "Laryngeal_Precancerous_Condition"                                                                                                                                     
 [6951] "Pancreatic_Precancerous_Condition"                                                                                                                                    
 [6952] "Nephrogenic_Adenoma"                                                                                                                                                  
 [6953] "Urinary_Bladder_Villous_Adenoma"                                                                                                                                      
 [6954] "Urinary_Bladder_Nephrogenic_Adenoma"                                                                                                                                  
 [6955] "Urethral_Nephrogenic_Adenoma"                                                                                                                                         
 [6956] "Gallbladder_Hyperplastic_Polyp"                                                                                                                                       
 [6957] "Malignant_Rectal_Neoplasm"                                                                                                                                            
 [6958] "Acanthoma"                                                                                                                                                            
 [6959] "Malignant_Rectosigmoid_Neoplasm"                                                                                                                                      
 [6960] "Rectosigmoid_Carcinoma"                                                                                                                                               
 [6961] "Precancerous_Condition_by_Site"                                                                                                                                       
 [6962] "Esophageal_Precancerous_Condition"                                                                                                                                    
 [6963] "Gastric_Precancerous_Condition"                                                                                                                                       
 [6964] "Oral_Cavity_and_Lip_Precancerous_Condition"                                                                                                                           
 [6965] "Metastatic_Neoplasm_to_the_Rectum"                                                                                                                                    
 [6966] "Nonencapsulated_Sclerosing_Carcinoma"                                                                                                                                 
 [6967] "Nonencapsulated_Sclerosing_Neoplasm"                                                                                                                                  
 [6968] "Nonencapsulated_Sclerosing_Adenocarcinoma"                                                                                                                            
 [6969] "Malignant_Exocrine_Pancreas_Neoplasm"                                                                                                                                 
 [6970] "Malignant_Ovarian_Neoplasm"                                                                                                                                           
 [6971] "AIDS-Related_Cervical_Carcinoma"                                                                                                                                      
 [6972] "V-Ras-Ha_Gene"                                                                                                                                                        
 [6973] "AIDS-Related_Non-Hodgkin_s_Lymphoma_of_the_Cervix"                                                                                                                    
 [6974] "Pulmonary_Precancerous_Condition"                                                                                                                                     
 [6975] "Squamous_Lung_Dysplasia"                                                                                                                                              
 [6976] "Diffuse_Idiopathic_Pulmonary_Neuroendocrine_Cell_Hyperplasia"                                                                                                         
 [6977] "Infiltrating_Papillary_Adenocarcinoma"                                                                                                                                
 [6978] "Intraductal_Papillary_Adenocarcinoma_with_Invasion"                                                                                                                   
 [6979] "Papilloma"                                                                                                                                                            
 [6980] "Salivary_Gland_Myoepithelioma"                                                                                                                                        
 [6981] "Benign_Myoepithelioma"                                                                                                                                                
 [6982] "Non-Infiltrating_Cystic_Hypersecretory_Duct_Breast_Carcinoma"                                                                                                         
 [6983] "Infiltrating_Cystic_Hypersecretory_Duct_Breast_Carcinoma"                                                                                                             
 [6984] "Brain_Stem_Astrocytoma"                                                                                                                                               
 [6985] "Anaplastic_Brain_Stem_Glioma"                                                                                                                                         
 [6986] "Granular_Cell_Odontogenic_Fibroma"                                                                                                                                    
 [6987] "Hybrid_Odontogenic_Fibroma"                                                                                                                                           
 [6988] "Infiltrating_Angiolipoma"                                                                                                                                             
 [6989] "Intramuscular_Lipoma"                                                                                                                                                 
 [6990] "Infiltrating_Lipoma"                                                                                                                                                  
 [6991] "Odontogenic_Myxofibroma"                                                                                                                                              
 [6992] "Exocervical_Carcinoma"                                                                                                                                                
 [6993] "Lung_Hilum_Carcinoma"                                                                                                                                                 
 [6994] "Metastatic_Malignant_Neoplasm_to_the_Ovary"                                                                                                                           
 [6995] "Capillary_Hemangioma"                                                                                                                                                 
 [6996] "Juvenile_Hemangioma"                                                                                                                                                  
 [6997] "Infantile_Hemangioma"                                                                                                                                                 
 [6998] "Metastatic_Malignant_Neoplasm_to_the_Anus"                                                                                                                            
 [6999] "Growth_Hormone_Secreting_Pituitary_Adenoma"                                                                                                                           
 [7000] "Pituitary_Corticotropin_Secreting_Adenoma"                                                                                                                            
 [7001] "Acute_Myelomonocytic_Leukemia"                                                                                                                                        
 [7002] "Acute_Leukemia_of_Ambiguous_Lineage"                                                                                                                                  
 [7003] "CCDC6_Gene"                                                                                                                                                           
 [7004] "Acute_Erythroid_Leukemia_in_Remission"                                                                                                                                
 [7005] "Pure_Erythroid_Leukemia"                                                                                                                                              
 [7006] "Struma_Ovarii"                                                                                                                                                        
 [7007] "Anal_Canal_Squamous_Cell_Carcinoma"                                                                                                                                   
 [7008] "Anal_Verrucous_Carcinoma"                                                                                                                                             
 [7009] "Anal_Canal_Adenocarcinoma"                                                                                                                                            
 [7010] "Anal_Margin_Carcinoma"                                                                                                                                                
 [7011] "Anal_Margin_Basal_Cell_Carcinoma"                                                                                                                                     
 [7012] "Anal_Extramucosal_Perianal_Adenocarcinoma"                                                                                                                            
 [7013] "Anal_Adenocarcinoma_within_Anorectal_Fistula"                                                                                                                         
 [7014] "Anal_Margin_Paget_s_Disease"                                                                                                                                          
 [7015] "Anal_Canal_Paget_s_Disease"                                                                                                                                           
 [7016] "Malignant_Esophageal_Neoplasm"                                                                                                                                        
 [7017] "Metastatic_Neoplasm_to_the_Esophagus"                                                                                                                                 
 [7018] "Malignant_Fallopian_Tube_Neoplasm"                                                                                                                                    
 [7019] "Malignant_Gallbladder_Neoplasm"                                                                                                                                       
 [7020] "Metastatic_Neoplasm_to_the_Gallbladder"                                                                                                                               
 [7021] "Malignant_Extrahepatic_Bile_Duct_Neoplasm"                                                                                                                            
 [7022] "Malignant_Laryngeal_Neoplasm"                                                                                                                                         
 [7023] "Malignant_Lip_Neoplasm"                                                                                                                                               
 [7024] "Paranasal_Sinus_Polyp"                                                                                                                                                
 [7025] "Malignant_Paranasal_Sinus_Neoplasm"                                                                                                                                   
 [7026] "Paranasal_Sinus_Neoplasm"                                                                                                                                             
 [7027] "Anal_Canal_Carcinoma"                                                                                                                                                 
 [7028] "Anal_Canal_Intraepithelial_Neoplasia"                                                                                                                                 
 [7029] "Primary_Intraosseous_Carcinoma_Arising_de_novo"                                                                                                                       
 [7030] "Ameloblastic_Carcinoma"                                                                                                                                               
 [7031] "De_novo_Ameloblastic_Carcinoma"                                                                                                                                       
 [7032] "Central_Ameloblastic_Carcinoma"                                                                                                                                       
 [7033] "Peripheral_Ameloblastic_Carcinoma"                                                                                                                                    
 [7034] "Ameloblastic_Carcinoma_ex_Ameloblastoma"                                                                                                                              
 [7035] "Ameloblastic_Carcinoma_ex_Odontogenic_Cyst"                                                                                                                           
 [7036] "Keratinizing_Primary_Intraosseous_Carcinoma_Arising_de_novo"                                                                                                          
 [7037] "Non-Keratinizing_Primary_Intraosseous_Carcinoma_Arising_de_novo"                                                                                                      
 [7038] "Primary_Intraosseous_Carcinoma_ex_Odontogenic_Cyst"                                                                                                                   
 [7039] "Odontogenic_Myxoma"                                                                                                                                                   
 [7040] "Malignant_Vulvar_Neoplasm"                                                                                                                                            
 [7041] "Borderline_Phyllodes_Tumor"                                                                                                                                           
 [7042] "Cystic_Nephroma"                                                                                                                                                      
 [7043] "Malignant_Cystic_Nephroma"                                                                                                                                            
 [7044] "Refractory_Anemia_with_Excess_Blasts"                                                                                                                                 
 [7045] "Malignant_Urethral_Neoplasm"                                                                                                                                          
 [7046] "Recurrent_Urethral_Cancer"                                                                                                                                            
 [7047] "Metastatic_Neoplasm_to_the_Thyroid_Gland"                                                                                                                             
 [7048] "Malignant_Thyroid_Neoplasm"                                                                                                                                           
 [7049] "Metastatic_Neoplasm_to_the_Breast"                                                                                                                                    
 [7050] "Malignant_Esophageal_Neoplasm_by_Anatomic_Region"                                                                                                                     
 [7051] "Malignant_Esophageal_Neoplasm_by_Topographic_Region"                                                                                                                  
 [7052] "Kidney_and_Ureter_Neoplasm"                                                                                                                                           
 [7053] "Renal_Pelvis_and_Ureter_Carcinoma"                                                                                                                                    
 [7054] "Stage_0a_Renal_Pelvis_and_Ureter_Carcinoma"                                                                                                                           
 [7055] "Stage_0is_Renal_Pelvis_and_Ureter_Carcinoma"                                                                                                                          
 [7056] "Stage_I_Renal_Pelvis_and_Ureter_Carcinoma"                                                                                                                            
 [7057] "Stage_II_Renal_Pelvis_and_Ureter_Carcinoma"                                                                                                                           
 [7058] "Stage_III_Renal_Pelvis_and_Ureter_Carcinoma"                                                                                                                          
 [7059] "Stage_IV_Renal_Pelvis_and_Ureter_Carcinoma"                                                                                                                           
 [7060] "Malignant_Small_Intestinal_Neoplasm"                                                                                                                                  
 [7061] "Metastasis_to_the_Small_Intestine"                                                                                                                                    
 [7062] "Malignant_Renal_Pelvis_Neoplasm"                                                                                                                                      
 [7063] "Endovascular_Papillary_Angioendothelioma"                                                                                                                             
 [7064] "Malignant_Superior_Sulcus_Neoplasm"                                                                                                                                   
 [7065] "Angioimmunoblastic_T-Cell_Lymphoma"                                                                                                                                   
 [7066] "Recurrent_Childhood_Visual_Pathway_Glioma"                                                                                                                            
 [7067] "Recurrent_Childhood_Visual_Pathway_Astrocytoma"                                                                                                                       
 [7068] "Recurrent_Childhood_Optic_Nerve_Glioma"                                                                                                                               
 [7069] "Recurrent_Childhood_Optic_Nerve_Astrocytoma"                                                                                                                          
 [7070] "Visual_Pathway_Astrocytoma"                                                                                                                                           
 [7071] "Childhood_Visual_Pathway_Astrocytoma"                                                                                                                                 
 [7072] "Childhood_Visual_Pathway_Glioma"                                                                                                                                      
 [7073] "Desmoplastic_Nodular_Medulloblastoma"                                                                                                                                 
 [7074] "Anterior_Visual_Pathway_Meningioma"                                                                                                                                   
 [7075] "Lymphoid_Leukemia"                                                                                                                                                    
 [7076] "Small_Lymphocytic_Lymphoma"                                                                                                                                           
 [7077] "Retinoblastoma"                                                                                                                                                       
 [7078] "Askin_s_Tumor"                                                                                                                                                        
 [7079] "Malignant_Ureter_Neoplasm"                                                                                                                                            
 [7080] "Metastatic_Neoplasm_to_the_Ureter"                                                                                                                                    
 [7081] "Malignant_Pharyngeal_Neoplasm"                                                                                                                                        
 [7082] "Metastatic_Neoplasm_to_the_Pharynx"                                                                                                                                   
 [7083] "Malignant_Penile_Neoplasm"                                                                                                                                            
 [7084] "Malignant_Renal_Neoplasm"                                                                                                                                             
 [7085] "Metastatic_Neoplasm_to_the_Kidney"                                                                                                                                    
 [7086] "Ovarian_Serous_Adenocarcinoma"                                                                                                                                        
 [7087] "Stage_III_Prostate_Cancer"                                                                                                                                            
 [7088] "Stage_C_Prostate_Cancer"                                                                                                                                              
 [7089] "Stage_II_Prostate_Cancer"                                                                                                                                             
 [7090] "Stage_B_Prostate_Cancer"                                                                                                                                              
 [7091] "Stage_I_Prostate_Cancer"                                                                                                                                              
 [7092] "Stage_A_Prostate_Cancer"                                                                                                                                              
 [7093] "Endometrial_Carcinoma"                                                                                                                                                
 [7094] "Atypical_Adenoma"                                                                                                                                                     
 [7095] "Sweat_Gland_Adenoma"                                                                                                                                                  
 [7096] "Syringadenoma"                                                                                                                                                        
 [7097] "Hidradenoma"                                                                                                                                                          
 [7098] "Eccrine_Cystadenoma"                                                                                                                                                  
 [7099] "Sporadic_Breast_Carcinoma"                                                                                                                                            
 [7100] "Clear_Cell_Hidradenoma"                                                                                                                                               
 [7101] "Nodular_Hidradenoma"                                                                                                                                                  
 [7102] "Thymoma_Type_C"                                                                                                                                                       
 [7103] "Melanocytic_Nevus"                                                                                                                                                    
 [7104] "Benign_Melanocytic_Nevus"                                                                                                                                             
 [7105] "Renal_Medullary_Carcinoma"                                                                                                                                            
 [7106] "Metastatic_Neoplasm_to_the_Urethra"                                                                                                                                   
 [7107] "Phyllodes_Tumor_of_the_Prostate"                                                                                                                                      
 [7108] "Phyllodes_Tumor_of_the_Breast"                                                                                                                                        
 [7109] "Deep_Penetrating_Nevus"                                                                                                                                               
 [7110] "Recurrent_Nevus"                                                                                                                                                      
 [7111] "Nevus_of_External_Female_Genitalia"                                                                                                                                   
 [7112] "Skin_Appendage_Adenoma"                                                                                                                                               
 [7113] "Microcystic_Adnexal_Carcinoma"                                                                                                                                        
 [7114] "Nevus_of_Ito"                                                                                                                                                         
 [7115] "Nevus_of_Ota"                                                                                                                                                         
 [7116] "Dysplastic_Nevus_Syndrome"                                                                                                                                            
 [7117] "Adamantinoid_Basal_Cell_Carcinoma"                                                                                                                                    
 [7118] "Malignant_Basal_Cell_Neoplasm"                                                                                                                                        
 [7119] "Adult_Lymphoma"                                                                                                                                                       
 [7120] "Common_Hematopoietic_Neoplasm"                                                                                                                                        
 [7121] "Common_Epithelial_Neoplasm"                                                                                                                                           
 [7122] "Common_Neuroendocrine_Neoplasm"                                                                                                                                       
 [7123] "Combined_Lung_Carcinoma"                                                                                                                                              
 [7124] "Common_Nervous_System_Neoplasm"                                                                                                                                       
 [7125] "Common_Germ_Cell_Neoplasm"                                                                                                                                            
 [7126] "Common_Connective_and_Soft_Tissue_Neoplasm"                                                                                                                           
 [7127] "Common_Melanocytic_Neoplasm"                                                                                                                                          
 [7128] "Myoepithelial_Carcinoma"                                                                                                                                              
 [7129] "Stage_IV_Vaginal_Cancer"                                                                                                                                              
 [7130] "Bone_Liposarcoma"                                                                                                                                                     
 [7131] "Acute_Myeloid_Leukemia_with_Multilineage_Dysplasia"                                                                                                                   
 [7132] "Thyroid_Mucosa-Associated_Lymphoid_Tissue_Lymphoma"                                                                                                                   
 [7133] "Halo_Nevus"                                                                                                                                                           
 [7134] "Regressing_Nevus"                                                                                                                                                     
 [7135] "Nasal_Cavity_Olfactory_Neuroblastoma"                                                                                                                                 
 [7136] "Oral_Cavity_Benign_Granular_Cell_Tumor"                                                                                                                               
 [7137] "Oral_Cavity_Neoplasm"                                                                                                                                                 
 [7138] "Benign_Oral_Cavity_Neoplasm"                                                                                                                                          
 [7139] "Benign_Oral_Neoplasm"                                                                                                                                                 
 [7140] "Cerebral_Non-Hodgkin_s_Lymphoma"                                                                                                                                      
 [7141] "Primary_Cerebral_Non-Hodgkin_s_Lymphoma"                                                                                                                              
 [7142] "Cerebral_Lymphoma"                                                                                                                                                    
 [7143] "Malignant_Thymoma"                                                                                                                                                    
 [7144] "Primary_Cutaneous_Hodgkin_s_Lymphoma"                                                                                                                                 
 [7145] "Cutaneous_Lymphoproliferative_Disorder"                                                                                                                               
 [7146] "Adult_Diffuse_Large_B-Cell_Lymphoma"                                                                                                                                  
 [7147] "Childhood_Diffuse_Large_B_Cell_Lymphoma"                                                                                                                              
 [7148] "Benign_Reproductive_System_Neoplasm"                                                                                                                                  
 [7149] "Benign_Mesenchymal_Cell_Neoplasm"                                                                                                                                     
 [7150] "Recurrent_Carcinoma"                                                                                                                                                  
 [7151] "Recurrent_Female_Reproductive_System_Cancer"                                                                                                                          
 [7152] "Recurrent_Male_Reproductive_System_Cancer"                                                                                                                            
 [7153] "Recurrent_Gastrointestinal_System_Cancer"                                                                                                                             
 [7154] "Recurrent_Urinary_Tract_Cancer"                                                                                                                                       
 [7155] "Recurrent_Head_and_Neck_Cancer"                                                                                                                                       
 [7156] "Localized_Carcinoma"                                                                                                                                                  
 [7157] "Recurrent_Pancreatic_Cancer"                                                                                                                                          
 [7158] "Bilateral_Malignant_Neoplasm"                                                                                                                                         
 [7159] "Refractory_Neoplasm"                                                                                                                                                  
 [7160] "Common_Carcinoma"                                                                                                                                                     
 [7161] "Intermediate_Lipomatous_Neoplasm"                                                                                                                                     
 [7162] "Malignant_Pericardial_Mesothelioma"                                                                                                                                   
 [7163] "Pericardial_Mesothelioma"                                                                                                                                             
 [7164] "Peritoneal_Mesothelioma"                                                                                                                                              
 [7165] "Solitary_Fibrous_Tumor"                                                                                                                                               
 [7166] "Well-Differentiated_Papillary_Mesothelioma"                                                                                                                           
 [7167] "Progressive_Myoclonus_Epilepsy"                                                                                                                                       
 [7168] "Malignant_Labia_Minora_Neoplasm"                                                                                                                                      
 [7169] "Malignant_Labia_Majora_Neoplasm"                                                                                                                                      
 [7170] "Regional_Malignant_Urethral_Neoplasm"                                                                                                                                 
 [7171] "Posterior_Urethral_Malignant_Neoplasm"                                                                                                                                
 [7172] "Anterior_Urethral_Malignant_Neoplasm"                                                                                                                                 
 [7173] "Epipodophyllotoxin-Related_Myelodysplastic_Syndrome"                                                                                                                  
 [7174] "Alkylating_Agent-Related_Myelodysplastic_Syndrome"                                                                                                                    
 [7175] "Adamantinoma"                                                                                                                                                         
 [7176] "Intracystic_Papillary_Carcinoma"                                                                                                                                      
 [7177] "Adrenal_Ganglioneuroblastoma"                                                                                                                                         
 [7178] "Adult_Mesoblastic_Nephroma"                                                                                                                                           
 [7179] "Localized_Gallbladder_Carcinoma"                                                                                                                                      
 [7180] "Metastatic_Neoplasm_to_the_Bladder"                                                                                                                                   
 [7181] "Metastatic_Neoplasm_to_Major_Site"                                                                                                                                    
 [7182] "Intermediate_Soft_Tissue_Neoplasm"                                                                                                                                    
 [7183] "Cellular_Precursor_of_Cancer"                                                                                                                                         
 [7184] "Hepato-Biliary_Precancerous_Condition"                                                                                                                                
 [7185] "Hepatic_Dysplastic_Nodule"                                                                                                                                            
 [7186] "Intestinal_Precancerous_Condition"                                                                                                                                    
 [7187] "Intestinal_Intraepithelial_Neoplasia"                                                                                                                                 
 [7188] "Gastrointestinal_Precancerous_Condition"                                                                                                                              
 [7189] "Grade_II_Glandular_Intraepithelial_Neoplasia"                                                                                                                         
 [7190] "Low_Grade_Glandular_Intraepithelial_Neoplasia"                                                                                                                        
 [7191] "High_Grade_Glandular_Intraepithelial_Neoplasia"                                                                                                                       
 [7192] "High_Grade_Vaginal_Intraepithelial_Neoplasia"                                                                                                                         
 [7193] "High_Grade_Vulvar_Intraepithelial_Neoplasia"                                                                                                                          
 [7194] "Grade_II_Penile_Intraepithelial_Neoplasia"                                                                                                                            
 [7195] "Low_Grade_Penile_Intraepithelial_Neoplasia"                                                                                                                           
 [7196] "High_Grade_Penile_Intraepithelial_Neoplasia"                                                                                                                          
 [7197] "High_Grade_Conjunctival_Intraepithelial_Neoplasia"                                                                                                                    
 [7198] "High_Grade_Corneal_Intraepithelial_Neoplasia"                                                                                                                         
 [7199] "High_Grade_Cervical_Intraepithelial_Neoplasia"                                                                                                                        
 [7200] "Cervical_Glandular_Intraepithelial_Neoplasia"                                                                                                                         
 [7201] "Low_Grade_Cervical_Glandular_Intraepithelial_Neoplasia"                                                                                                               
 [7202] "High_Grade_Cervical_Glandular_Intraepithelial_Neoplasia"                                                                                                              
 [7203] "Adenocarcinoma_in_Adenomatous_Polyp"                                                                                                                                  
 [7204] "Adenocarcinoma_in_Tubular_Adenoma"                                                                                                                                    
 [7205] "Adenocarcinoma_in_situ_in_Adenomatous_Polyp"                                                                                                                          
 [7206] "Adenocarcinoma_in_situ_in_Tubular_Adenoma"                                                                                                                            
 [7207] "Adenocarcinoma_in_situ_in_a_Polyp"                                                                                                                                    
 [7208] "Carcinoma_in_situ_in_a_Polyp"                                                                                                                                         
 [7209] "Carcinoma_in_a_Polyp"                                                                                                                                                 
 [7210] "Adenocarcinoma_with_Cartilaginous_and_Osseous_Metaplasia"                                                                                                             
 [7211] "Adenocarcinoma_with_Osseous_Metaplasia"                                                                                                                               
 [7212] "Adenocarcinoma_with_Cartilaginous_Metaplasia"                                                                                                                         
 [7213] "Noninfiltrating_Intracystic_Breast_Carcinoma"                                                                                                                         
 [7214] "Intracystic_Breast_Carcinoma"                                                                                                                                         
 [7215] "Invasive_Ductal_and_Lobular_Carcinoma"                                                                                                                                
 [7216] "Infiltrating_Ductal_and_Lobular_Carcinoma_in_situ"                                                                                                                    
 [7217] "Intraductal_and_Lobular_Carcinoma"                                                                                                                                    
 [7218] "Resectable_Hepatocellular_Carcinoma"                                                                                                                                  
 [7219] "Resectable_Hepatic_Malignant_Neoplasm"                                                                                                                                
 [7220] "Precancerous_Atypia"                                                                                                                                                  
 [7221] "Cervical_Precancerous_Atypia"                                                                                                                                         
 [7222] "Primary_Serous_Papillary_Carcinoma_of_Peritoneum"                                                                                                                     
 [7223] "Stage_IV_Inflammatory_Breast_Carcinoma"                                                                                                                               
 [7224] "Nicotine_Withdrawal"                                                                                                                                                  
 [7225] "Gastric_Adenoma"                                                                                                                                                      
 [7226] "Ovarian_Adenocarcinoma"                                                                                                                                               
 [7227] "Reactive_Lymphocyte_Count"                                                                                                                                            
 [7228] "Adult_Hodgkin_s_Lymphoma"                                                                                                                                             
 [7229] "Childhood_Brain_Neoplasm"                                                                                                                                             
 [7230] "Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                                         
 [7231] "Childhood_Rhabdomyosarcoma"                                                                                                                                           
 [7232] "Childhood_Non-Hodgkin_s_Lymphoma"                                                                                                                                     
 [7233] "Adult_Soft_Tissue_Sarcoma"                                                                                                                                            
 [7234] "Childhood_Liver_Cancer"                                                                                                                                               
 [7235] "Gastrointestinal_Carcinoid_Tumor"                                                                                                                                     
 [7236] "Adult_Brain_Neoplasm"                                                                                                                                                 
 [7237] "Adult_Liver_Carcinoma"                                                                                                                                                
 [7238] "Uveal_Melanoma"                                                                                                                                                       
 [7239] "Squamous_Cell_Carcinoma_Metastatic_to_the_Neck_with_Occult_Primary"                                                                                                   
 [7240] "Childhood_Hodgkin_s_Lymphoma"                                                                                                                                         
 [7241] "Childhood_Soft_Tissue_Sarcoma"                                                                                                                                        
 [7242] "Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter"                                                                                                           
 [7243] "Malignant_Pericardial_Effusion"                                                                                                                                       
 [7244] "Appendix_Adenocarcinoma"                                                                                                                                              
 [7245] "Bartholin_s_Gland_Adenocarcinoma"                                                                                                                                     
 [7246] "Gallbladder_Adenoma"                                                                                                                                                  
 [7247] "Gingival_Carcinoma"                                                                                                                                                   
 [7248] "Cardiac_Fibroma"                                                                                                                                                      
 [7249] "Cardiac_Sarcoma"                                                                                                                                                      
 [7250] "Small_Intestinal_Carcinoma"                                                                                                                                           
 [7251] "Small_Intestinal_Leiomyoma"                                                                                                                                           
 [7252] "Renal_Fibrosarcoma"                                                                                                                                                   
 [7253] "Light_Chain_Deposition_Disease"                                                                                                                                       
 [7254] "Scrotal_Paget_s_Disease"                                                                                                                                              
 [7255] "Squamous_Cell_Carcinoma_of_the_Penis"                                                                                                                                 
 [7256] "Penile_Sarcoma"                                                                                                                                                       
 [7257] "Prostate_Sarcoma"                                                                                                                                                     
 [7258] "Renal_Pelvis_Squamous_Cell_Carcinoma"                                                                                                                                 
 [7259] "Testicular_Choriocarcinoma"                                                                                                                                           
 [7260] "Tongue_Lipoma"                                                                                                                                                        
 [7261] "Vaginal_Clear_Cell_Adenocarcinoma"                                                                                                                                    
 [7262] "Vaginal_Squamous_Cell_Carcinoma"                                                                                                                                      
 [7263] "Vaginal_Sarcoma"                                                                                                                                                      
 [7264] "Brain_Hemangioma"                                                                                                                                                     
 [7265] "Peau_d_orange"                                                                                                                                                        
 [7266] "Gastrointestinal_Hemangioma"                                                                                                                                          
 [7267] "Squamous_Papilloma_of_the_Larynx"                                                                                                                                     
 [7268] "Mouth_Mucous_Membrane_Leukoplakia"                                                                                                                                    
 [7269] "Mucous_Membrane_Hemangioma"                                                                                                                                           
 [7270] "Mucous_Membrane_Leukoplakia"                                                                                                                                          
 [7271] "Scrotal_Cyst"                                                                                                                                                         
 [7272] "Lung_Hemangioma"                                                                                                                                                      
 [7273] "Endocardial_Myxoma"                                                                                                                                                   
 [7274] "Cutaneous_Fibrohistiocytic_Neoplasm"                                                                                                                                  
 [7275] "Angiokeratoma_Circumscriptum"                                                                                                                                         
 [7276] "Scrotal_Angiokeratoma"                                                                                                                                                
 [7277] "Malignant_Pericarditis"                                                                                                                                               
 [7278] "Juvenile_Polyposis_Syndrome"                                                                                                                                          
 [7279] "Peutz-Jeghers_Polyp_of_the_Small_Intestine"                                                                                                                           
 [7280] "Squamous_Metaplasia_of_Rectal_Mucosa"                                                                                                                                 
 [7281] "DNA_Repair_Disorder"                                                                                                                                                  
 [7282] "Prostatic_Squamous_Metaplasia"                                                                                                                                        
 [7283] "Apocrine_Metaplasia_of_Breast"                                                                                                                                        
 [7284] "Extratemporal_Epilepsy"                                                                                                                                               
 [7285] "Iris_Implantation_Cyst"                                                                                                                                               
 [7286] "Ciliary_Body_Implantation_Cyst"                                                                                                                                       
 [7287] "Hurthle_Cell_Metaplasia_of_Thyroid_Gland"                                                                                                                             
 [7288] "Atypical_Lymphoproliferative_Disorder"                                                                                                                                
 [7289] "Osteosclerotic_Myeloma"                                                                                                                                               
 [7290] "Stage_III_Colon_Cancer"                                                                                                                                               
 [7291] "Stage_I_Breast_Cancer"                                                                                                                                                
 [7292] "Stage_II_Breast_Cancer"                                                                                                                                               
 [7293] "Stage_III_Breast_Cancer"                                                                                                                                              
 [7294] "Stage_IIIA_Breast_Cancer"                                                                                                                                             
 [7295] "Recurrent_Breast_Cancer"                                                                                                                                              
 [7296] "Stage_I_Gastric_Cancer"                                                                                                                                               
 [7297] "Stage_II_Gastric_Cancer"                                                                                                                                              
 [7298] "Stage_III_Gastric_Cancer"                                                                                                                                             
 [7299] "Stage_II_Anal_Canal_Cancer"                                                                                                                                           
 [7300] "Stage_III_Anal_Canal_Cancer"                                                                                                                                          
 [7301] "Stage_II_Non-Small_Cell_Lung_Cancer"                                                                                                                                  
 [7302] "Stage_III_Non-Small_Cell_Lung_Cancer"                                                                                                                                 
 [7303] "Superior_Sulcus_Lung_Carcinoma"                                                                                                                                       
 [7304] "Localized_Osteosarcoma"                                                                                                                                               
 [7305] "Metastatic_Osteosarcoma"                                                                                                                                              
 [7306] "Stage_IIIB_Breast_Cancer"                                                                                                                                             
 [7307] "Recurrent_Non-Small_Cell_Lung_Cancer"                                                                                                                                 
 [7308] "Recurrent_Childhood_Acute_Lymphoblastic_Leukemia"                                                                                                                     
 [7309] "Stage_I_Pancreatic_Cancer"                                                                                                                                            
 [7310] "Stage_II_Pancreatic_Cancer"                                                                                                                                           
 [7311] "Stage_III_Pancreatic_Cancer"                                                                                                                                          
 [7312] "Stage_0_Gastric_Cancer"                                                                                                                                               
 [7313] "Recurrent_Adult_Hodgkin_s_Lymphoma"                                                                                                                                   
 [7314] "Stage_I_Rectal_Cancer"                                                                                                                                                
 [7315] "Stage_II_Rectal_Cancer"                                                                                                                                               
 [7316] "Stage_III_Rectal_Cancer"                                                                                                                                              
 [7317] "Recurrent_Anal_Canal_Cancer"                                                                                                                                          
 [7318] "Stage_0_Anal_Canal_Cancer"                                                                                                                                            
 [7319] "Stage_I_Cutaneous_T-Cell_Lymphoma"                                                                                                                                    
 [7320] "Stage_I_Mycosis_Fungoides"                                                                                                                                            
 [7321] "Stage_II_Cutaneous_T-Cell_Lymphoma"                                                                                                                                   
 [7322] "Stage_II_Mycosis_Fungoides"                                                                                                                                           
 [7323] "Stage_III_Cutaneous_T-Cell_Lymphoma"                                                                                                                                  
 [7324] "Stage_III_Mycosis_Fungoides"                                                                                                                                          
 [7325] "Stage_IV_Cutaneous_T-Cell_Lymphoma"                                                                                                                                   
 [7326] "Stage_IV_Mycosis_Fungoides"                                                                                                                                           
 [7327] "Stage_II_Cervical_Cancer"                                                                                                                                             
 [7328] "Recurrent_Cervical_Carcinoma"                                                                                                                                         
 [7329] "Recurrent_Cutaneous_T-Cell_Lymphoma"                                                                                                                                  
 [7330] "Localized_Ewing_s_Sarcoma"                                                                                                                                            
 [7331] "Metastatic_Ewing_s_Sarcoma"                                                                                                                                           
 [7332] "Recurrent_Ewing_s_Sarcoma"                                                                                                                                            
 [7333] "Adult_Fibrosarcoma"                                                                                                                                                   
 [7334] "Adult_Leiomyosarcoma"                                                                                                                                                 
 [7335] "Adult_Liposarcoma"                                                                                                                                                    
 [7336] "Solitary_Osseous_Plasmacytoma"                                                                                                                                        
 [7337] "Refractory_Plasma_Cell_Neoplasm"                                                                                                                                      
 [7338] "Adult_Malignant_Peripheral_Nerve_Sheath_Tumor"                                                                                                                        
 [7339] "Recurrent_Childhood_Rhabdomyosarcoma"                                                                                                                                 
 [7340] "Childhood_Craniopharyngioma"                                                                                                                                          
 [7341] "Adult_Synovial_Sarcoma"                                                                                                                                               
 [7342] "Stage_I_Adult_Soft_Tissue_Sarcoma"                                                                                                                                    
 [7343] "Stage_II_Adult_Soft_Tissue_Sarcoma"                                                                                                                                   
 [7344] "Stage_III_Adult_Soft_Tissue_Sarcoma"                                                                                                                                  
 [7345] "Stage_IV_Adult_Soft_Tissue_Sarcoma"                                                                                                                                   
 [7346] "Recurrent_Adult_Soft_Tissue_Sarcoma"                                                                                                                                  
 [7347] "Stage_I_Renal_Cell_Cancer"                                                                                                                                            
 [7348] "Stage_II_Renal_Cell_Cancer"                                                                                                                                           
 [7349] "Recurrent_Renal_Cell_Carcinoma"                                                                                                                                       
 [7350] "Localized_Parathyroid_Carcinoma"                                                                                                                                      
 [7351] "Metastatic_Parathyroid_Neoplasm"                                                                                                                                      
 [7352] "Recurrent_Parathyroid_Carcinoma"                                                                                                                                      
 [7353] "Stage_I_Ovarian_Cancer"                                                                                                                                               
 [7354] "Stage_II_Ovarian_Cancer"                                                                                                                                              
 [7355] "Stage_III_Ovarian_Cancer"                                                                                                                                             
 [7356] "Stage_IV_Ovarian_Cancer"                                                                                                                                              
 [7357] "Recurrent_Ovarian_Cancer"                                                                                                                                             
 [7358] "Recurrent_Childhood_Brain_Neoplasm"                                                                                                                                   
 [7359] "Localized_Resectable_Neuroblastoma"                                                                                                                                   
 [7360] "Regional_Neuroblastoma"                                                                                                                                               
 [7361] "Recurrent_Neuroblastoma"                                                                                                                                              
 [7362] "Stage_IV_Childhood_Hepatocellular_Carcinoma"                                                                                                                          
 [7363] "Recurrent_Childhood_Liver_Cancer"                                                                                                                                     
 [7364] "Stage_I_Wilms_Tumor"                                                                                                                                                  
 [7365] "Stage_II_Wilms_Tumor"                                                                                                                                                 
 [7366] "Stage_III_Wilms_Tumor"                                                                                                                                                
 [7367] "Stage_IV_Wilms_Tumor"                                                                                                                                                 
 [7368] "Stage_V_Wilms_Tumor"                                                                                                                                                  
 [7369] "Recurrent_Wilms_Tumor"                                                                                                                                                
 [7370] "Intraocular_Retinoblastoma"                                                                                                                                           
 [7371] "Stage_0_Chronic_Lymphocytic_Leukemia"                                                                                                                                 
 [7372] "Extraocular_Retinoblastoma"                                                                                                                                           
 [7373] "Recurrent_Retinoblastoma"                                                                                                                                             
 [7374] "Stage_I_Multiple_Myeloma"                                                                                                                                             
 [7375] "Stage_II_Multiple_Myeloma"                                                                                                                                            
 [7376] "Stage_III_Multiple_Myeloma"                                                                                                                                           
 [7377] "Limited_Stage_Small_Cell_Lung_Carcinoma"                                                                                                                              
 [7378] "Stage_I_Vulvar_Cancer"                                                                                                                                                
 [7379] "Stage_0_Vaginal_Cancer"                                                                                                                                               
 [7380] "Stage_I_Vaginal_Cancer"                                                                                                                                               
 [7381] "Stage_II_Vaginal_Cancer"                                                                                                                                              
 [7382] "Stage_III_Vaginal_Cancer"                                                                                                                                             
 [7383] "Stage_IVA_Vaginal_Cancer"                                                                                                                                             
 [7384] "Recurrent_Vaginal_Cancer"                                                                                                                                             
 [7385] "Localized_Gastrointestinal_Carcinoid_Tumor"                                                                                                                           
 [7386] "Regional_Gastrointestinal_Carcinoid_Tumor"                                                                                                                            
 [7387] "Recurrent_Gastrointestinal_Carcinoid_Tumor"                                                                                                                           
 [7388] "Advanced_Malignant_Mesothelioma"                                                                                                                                      
 [7389] "Recurrent_Malignant_Mesothelioma"                                                                                                                                     
 [7390] "Stage_I_Penile_Cancer"                                                                                                                                                
 [7391] "Stage_II_Penile_Cancer"                                                                                                                                               
 [7392] "Stage_III_Penile_Cancer"                                                                                                                                              
 [7393] "Recurrent_Penile_Cancer"                                                                                                                                              
 [7394] "Adult_Diffuse_Mixed_Cell_Lymphoma"                                                                                                                                    
 [7395] "Adult_Diffuse_Large_Cell_Lymphoma"                                                                                                                                    
 [7396] "Adult_Immunoblastic_Lymphoma"                                                                                                                                         
 [7397] "Stage_I_Chronic_Lymphocytic_Leukemia"                                                                                                                                 
 [7398] "Stage_II_Chronic_Lymphocytic_Leukemia"                                                                                                                                
 [7399] "Stage_III_Chronic_Lymphocytic_Leukemia"                                                                                                                               
 [7400] "Localized_Resectable_Adult_Liver_Cancer"                                                                                                                              
 [7401] "Localized_Unresectable_Adult_Liver_Cancer"                                                                                                                            
 [7402] "Recurrent_Adult_Liver_Cancer"                                                                                                                                         
 [7403] "Recurrent_Osteosarcoma"                                                                                                                                               
 [7404] "Recurrent_Adult_Acute_Myeloid_Leukemia"                                                                                                                               
 [7405] "Recurrent_Adult_Acute_Lymphoblastic_Leukemia"                                                                                                                         
 [7406] "Recurrent_Adult_Brain_Neoplasm"                                                                                                                                       
 [7407] "Refractory_Chronic_Myelogenous_Leukemia"                                                                                                                              
 [7408] "Refractory_Chronic_Lymphocytic_Leukemia"                                                                                                                              
 [7409] "Recurrent_Gestational_Trophoblastic_Tumor"                                                                                                                            
 [7410] "Small_Intestinal_Adenocarcinoma"                                                                                                                                      
 [7411] "Duodenal_Adenocarcinoma"                                                                                                                                              
 [7412] "Unresectable_Gallbladder_Cancer"                                                                                                                                      
 [7413] "Localized_Extrahepatic_Bile_Duct_Carcinoma"                                                                                                                           
 [7414] "Unresectable_Extrahepatic_Bile_Duct_Carcinoma"                                                                                                                        
 [7415] "Recurrent_Extrahepatic_Bile_Duct_Carcinoma"                                                                                                                           
 [7416] "Recurrent_Small_Intestinal_Cancer"                                                                                                                                    
 [7417] "Stage_0_Bladder_Cancer"                                                                                                                                               
 [7418] "Stage_I_Bladder_Cancer"                                                                                                                                               
 [7419] "Stage_II_Bladder_Cancer"                                                                                                                                              
 [7420] "Stage_III_Bladder_Cancer"                                                                                                                                             
 [7421] "Recurrent_Bladder_Cancer"                                                                                                                                             
 [7422] "Stage_IV_Bladder_Cancer"                                                                                                                                              
 [7423] "Stage_I_Testicular_Cancer"                                                                                                                                            
 [7424] "Recurrent_Prostate_Cancer"                                                                                                                                            
 [7425] "Recurrent_Skin_Cancer"                                                                                                                                                
 [7426] "Invasive_Malignant_Thymoma"                                                                                                                                           
 [7427] "Recurrent_Malignant_Thymoma"                                                                                                                                          
 [7428] "Anaplastic_Giant_Cell_Thyroid_Carcinoma"                                                                                                                              
 [7429] "Anaplastic_Small_Cell_Thyroid_Carcinoma"                                                                                                                              
 [7430] "Recurrent_Thyroid_Carcinoma"                                                                                                                                          
 [7431] "Pituitary_Corticotropin_Secreting_Tumor"                                                                                                                              
 [7432] "Prolactin_Producing_Pituitary_Gland_Neoplasm"                                                                                                                         
 [7433] "Growth_Hormone_Secreting_Pituitary_Neoplasm"                                                                                                                          
 [7434] "Recurrent_Pituitary_Gland_Neoplasm"                                                                                                                                   
 [7435] "Extraocular_Extension_Melanoma"                                                                                                                                       
 [7436] "Recurrent_Uveal_Melanoma"                                                                                                                                             
 [7437] "Thyroid_Stimulating_Hormone_Producing_Pituitary_Gland_Neoplasm"                                                                                                       
 [7438] "Stage_I_Melanoma_of_the_Skin"                                                                                                                                         
 [7439] "Stage_II_Melanoma_of_the_Skin"                                                                                                                                        
 [7440] "Stage_III_Melanoma_of_the_Skin"                                                                                                                                       
 [7441] "No_Measurable_or_Evaluable_Disease"                                                                                                                                   
 [7442] "Stage_II_Nasopharyngeal_Carcinoma"                                                                                                                                    
 [7443] "New_York_Heart_Association_Class_III_IV"                                                                                                                              
 [7444] "Active_Peptic_Ulcer_Disease_GI_Bleeding"                                                                                                                              
 [7445] "Adult_Extraskeletal_Chondrosarcoma"                                                                                                                                   
 [7446] "Adult_Extraskeletal_Osteosarcoma"                                                                                                                                     
 [7447] "Recurrent_Salivary_Gland_Carcinoma"                                                                                                                                   
 [7448] "Liver_and_Intrahepatic_Biliary_Tract_Carcinoma"                                                                                                                       
 [7449] "Childhood_Germ_Cell_Neoplasm"                                                                                                                                         
 [7450] "Anticipatory_Nausea_and_Vomiting"                                                                                                                                     
 [7451] "Lymphomatoid_Granulomatosis"                                                                                                                                          
 [7452] "Grade_I_Lymphomatoid_Granulomatosis"                                                                                                                                  
 [7453] "Grade_II_Lymphomatoid_Granulomatosis"                                                                                                                                 
 [7454] "Grade_III_Lymphomatoid_Granulomatosis"                                                                                                                                
 [7455] "Recurrent_Lymphomatoid_Granulomatosis"                                                                                                                                
 [7456] "Recurrent_Kaposi_Sarcoma"                                                                                                                                             
 [7457] "Adult_Acute_Myeloid_Leukemia_in_Remission"                                                                                                                            
 [7458] "Adult_Acute_Lymphoblastic_Leukemia_in_Remission"                                                                                                                      
 [7459] "Childhood_Acute_Lymphoblastic_Leukemia_in_Remission"                                                                                                                  
 [7460] "Stage_0_Lip_and_Oral_Cavity_Cancer"                                                                                                                                   
 [7461] "Childhood_Acute_Monoblastic_Leukemia_and_Acute_Monocytic_Leukemia"                                                                                                    
 [7462] "Body_Temperature_Associated_Symptom"                                                                                                                                  
 [7463] "Adult_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma"                                                                                                              
 [7464] "Adult_Alveolar_Soft_Part_Sarcoma"                                                                                                                                     
 [7465] "Adult_Epithelioid_Sarcoma"                                                                                                                                            
 [7466] "Malignant_Adult_Hemangiopericytoma"                                                                                                                                   
 [7467] "Adult_Malignant_Mesenchymoma"                                                                                                                                         
 [7468] "Bronchogenic_Adenocarcinoma"                                                                                                                                          
 [7469] "High-Grade_Ductal_Carcinoma_In_Situ_of_the_Breast"                                                                                                                    
 [7470] "Invasive_Lobular_Breast_Carcinoma"                                                                                                                                    
 [7471] "Paget_s_Disease_of_the_Breast_with_Invasive_Ductal_Carcinoma"                                                                                                         
 [7472] "Childhood_Burkitt_s_Leukemia"                                                                                                                                         
 [7473] "Childhood_Precursor_T_Lymphoblastic_Leukemia"                                                                                                                         
 [7474] "Adult_Burkitt_s_Leukemia"                                                                                                                                             
 [7475] "Childhood_Hepatocellular_Carcinoma"                                                                                                                                   
 [7476] "Adult_Hepatocellular_Carcinoma"                                                                                                                                       
 [7477] "Childhood_Embryonal_Rhabdomyosarcoma"                                                                                                                                 
 [7478] "Childhood_Alveolar_Rhabdomyosarcoma"                                                                                                                                  
 [7479] "Childhood_Pleomorphic_Rhabdomyosarcoma"                                                                                                                               
 [7480] "Childhood_Mixed_Rhabdomyosarcoma"                                                                                                                                     
 [7481] "Adult_Acute_Myeloid_Leukemia_with_Maturation"                                                                                                                         
 [7482] "Adult_Acute_Myelomonocytic_Leukemia"                                                                                                                                  
 [7483] "Adult_Acute_Eosinophilic_Leukemia"                                                                                                                                    
 [7484] "Adult_Acute_Basophilic_Leukemia"                                                                                                                                      
 [7485] "Adult_Acute_Megakaryoblastic_Leukemia"                                                                                                                                
 [7486] "Colon_Mucinous_Adenocarcinoma"                                                                                                                                        
 [7487] "Colon_Signet_Ring_Adenocarcinoma"                                                                                                                                     
 [7488] "Childhood_Acute_Promyelocytic_Leukemia"                                                                                                                               
 [7489] "Childhood_Acute_Myelomonocytic_Leukemia"                                                                                                                              
 [7490] "Childhood_Acute_Basophilic_Leukemia"                                                                                                                                  
 [7491] "Childhood_Acute_Megakaryoblastic_Leukemia"                                                                                                                            
 [7492] "Rectal_Mucinous_Adenocarcinoma"                                                                                                                                       
 [7493] "Undifferentiated_Rectal_Carcinoma"                                                                                                                                    
 [7494] "Extrahepatic_Bile_Duct_Adenocarcinoma"                                                                                                                                
 [7495] "Distal_1_3_of_the_Common_Bile_Duct_Adenocarcinoma"                                                                                                                    
 [7496] "Pancreatic_Acinar_Cell_Carcinoma"                                                                                                                                     
 [7497] "Ovarian_Serous_Cystadenocarcinoma"                                                                                                                                    
 [7498] "Ovarian_Endometrioid_Adenocarcinoma"                                                                                                                                  
 [7499] "Ovarian_Clear_Cell_Cystadenocarcinoma"                                                                                                                                
 [7500] "Vaginal_Adenocarcinoma"                                                                                                                                               
 [7501] "Cervical_Small_Cell_Carcinoma"                                                                                                                                        
 [7502] "Borderline_Ovarian_Endometrioid_Tumor"                                                                                                                                
 [7503] "Epithelial_Mesothelioma"                                                                                                                                              
 [7504] "Spindle_Cell_Uveal_Melanoma"                                                                                                                                          
 [7505] "Spindle_Cell_Type_A_Uveal_Melanoma"                                                                                                                                   
 [7506] "Spindle_Cell_Type_B_Uveal_Melanoma"                                                                                                                                   
 [7507] "Intermediate_Cell_Type_Uveal_Melanoma"                                                                                                                                
 [7508] "Necrotic_Uveal_Melanoma"                                                                                                                                              
 [7509] "Salivary_Gland_Squamous_Cell_Carcinoma"                                                                                                                               
 [7510] "Nasopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                               
 [7511] "Parathyroid_Clear_Cell_Adenoma"                                                                                                                                       
 [7512] "Parathyroid_Mixed_Cell_Type_Adenoma"                                                                                                                                  
 [7513] "Granular_Renal_Cell_Carcinoma"                                                                                                                                        
 [7514] "Malignant_Type_B1_Thymoma"                                                                                                                                            
 [7515] "Thymoma_Type_B3"                                                                                                                                                      
 [7516] "Lymphoepithelioma-Like_Thymic_Carcinoma"                                                                                                                              
 [7517] "Malignant_Type_A_Thymoma"                                                                                                                                             
 [7518] "Testicular_Yolk_Sac_Tumor"                                                                                                                                            
 [7519] "Testicular_Mixed_Embryonal_Carcinoma_and_Yolk_Sack_Tumor"                                                                                                             
 [7520] "Testicular_Mixed_Yolk_Sac_Tumor_and_Teratoma"                                                                                                                         
 [7521] "Testicular_Mixed_Yolk_Sac_Tumor_and_Teratoma_with_Seminoma"                                                                                                           
 [7522] "Pancreatic_Delta_Cell_Somatostatin_Producing_Neoplasm"                                                                                                                
 [7523] "Thyroid_Stimulating_Hormone_Secreting_Pituitary_Gland_Adenoma"                                                                                                        
 [7524] "Low-Grade_Salivary_Gland_Carcinoma"                                                                                                                                   
 [7525] "Salivary_Gland_Acinic_Cell_Carcinoma"                                                                                                                                 
 [7526] "Lip_Basal_Cell_Carcinoma"                                                                                                                                             
 [7527] "Low-Grade_Salivary_Gland_Mucoepidermoid_Carcinoma"                                                                                                                    
 [7528] "Grade_I_Salivary_Gland_Mucoepidermoid_Carcinoma"                                                                                                                      
 [7529] "Grade_II_Salivary_Gland_Mucoepidermoid_Carcinoma"                                                                                                                     
 [7530] "High-Grade_Salivary_Gland_Carcinoma"                                                                                                                                  
 [7531] "High-Grade_Salivary_Gland_Mucoepidermoid_Carcinoma"                                                                                                                   
 [7532] "Grade_III_Salivary_Gland_Mucoepidermoid_Carcinoma"                                                                                                                    
 [7533] "Salivary_Gland_Adenocarcinoma"                                                                                                                                        
 [7534] "Poorly_Differentiated_Salivary_Gland_Carcinoma"                                                                                                                       
 [7535] "Nasopharyngeal_Undifferentiated_Carcinoma"                                                                                                                            
 [7536] "Undifferentiated_Salivary_Gland_Carcinoma"                                                                                                                            
 [7537] "Malignant_Mixed_Tumor_of_the_Salivary_Gland"                                                                                                                          
 [7538] "Salivary_Gland_Adenoid_Cystic_Carcinoma"                                                                                                                              
 [7539] "Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Squamous_Differentiation"                                                                                             
 [7540] "Endometrial_Clear_Cell_Carcinoma"                                                                                                                                     
 [7541] "Progressive_Hairy_Cell_Leukemia_Initial_Treatment"                                                                                                                    
 [7542] "Refractory_Hairy_Cell_Leukemia"                                                                                                                                       
 [7543] "Negative_Axillary_Lymph_Node"                                                                                                                                         
 [7544] "One_or_More_Positive_Axillary_Nodes"                                                                                                                                  
 [7545] "Stage_I_Lip_and_Oral_Cavity_Cancer"                                                                                                                                   
 [7546] "Stage_II_Lip_and_Oral_Cavity_Cancer"                                                                                                                                  
 [7547] "Stage_III_Lip_and_Oral_Cavity_Cancer"                                                                                                                                 
 [7548] "Stage_IV_Lip_and_Oral_Cavity_Cancer"                                                                                                                                  
 [7549] "Recurrent_Lip_and_Oral_Cavity_Cancer"                                                                                                                                 
 [7550] "Stage_I_Hypopharyngeal_Carcinoma"                                                                                                                                     
 [7551] "Stage_II_Hypopharyngeal_Carcinoma"                                                                                                                                    
 [7552] "Stage_III_Hypopharyngeal_Carcinoma"                                                                                                                                   
 [7553] "Stage_I_Laryngeal_Cancer"                                                                                                                                             
 [7554] "Stage_II_Laryngeal_Cancer"                                                                                                                                            
 [7555] "Stage_III_Laryngeal_Cancer"                                                                                                                                           
 [7556] "Regional_Pheochromocytoma"                                                                                                                                            
 [7557] "Metastatic_Pheochromocytoma"                                                                                                                                          
 [7558] "Recurrent_Pheochromocytoma"                                                                                                                                           
 [7559] "Stage_I_Oropharyngeal_Carcinoma"                                                                                                                                      
 [7560] "Stage_II_Oropharyngeal_Carcinoma"                                                                                                                                     
 [7561] "Stage_III_Oropharyngeal_Carcinoma"                                                                                                                                    
 [7562] "Recurrent_Oropharyngeal_Cancer"                                                                                                                                       
 [7563] "Oral_Complications_of_Cancer_and_Cancer_Therapy"                                                                                                                      
 [7564] "Malignant_Ovarian_Sex_Cord-Stromal_Tumor"                                                                                                                             
 [7565] "Follicular_Thyroid_Carcinoma"                                                                                                                                         
 [7566] "Stage_II_Pediatric_Hodgkin_s_Lymphoma"                                                                                                                                
 [7567] "Stage_I_Pediatric_Hodgkin_s_Lymphoma"                                                                                                                                 
 [7568] "Stage_III_Pediatric_Hodgkin_s_Lymphoma"                                                                                                                               
 [7569] "Stage_IV_Pediatric_Hodgkin_s_Lymphoma"                                                                                                                                
 [7570] "Recurrent_Childhood_Hodgkin_s_Lymphoma"                                                                                                                               
 [7571] "Childhood_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma"                                                                                                          
 [7572] "Childhood_Lymphocyte_Depleted_Hodgkin_s_Lymphoma"                                                                                                                     
 [7573] "Childhood_Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                                       
 [7574] "Childhood_Mixed_Cellularity_Hodgkin_s_Lymphoma"                                                                                                                       
 [7575] "Metastatic_Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter"                                                                                                
 [7576] "Primary_Childhood_Soft_Tissue_Sarcoma"                                                                                                                                
 [7577] "Metastatic_Childhood_Soft_Tissue_Sarcoma"                                                                                                                             
 [7578] "Recurrent_Childhood_Soft_Tissue_Sarcoma"                                                                                                                              
 [7579] "Adult_Non-Hodgkin_s_Lymphoma_Stage"                                                                                                                                   
 [7580] "Stage_I_Low-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                       
 [7581] "Stage_I_Small_Lymphocytic_Lymphoma"                                                                                                                                   
 [7582] "Stage_I_Grade_1_Follicular_Lymphoma"                                                                                                                                  
 [7583] "Stage_I_Grade_2_Follicular_Lymphoma"                                                                                                                                  
 [7584] "Stage_I_Grade_3_Follicular_Lymphoma"                                                                                                                                  
 [7585] "Stage_I_Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                              
 [7586] "Stage_I_Adult_Diffuse_Small_Cleaved_Cell_Lymphoma"                                                                                                                    
 [7587] "Stage_I_Adult_Diffuse_Mixed_Cell_Lymphoma"                                                                                                                            
 [7588] "Stage_I_Adult_Diffuse_Large_Cell_Lymphoma"                                                                                                                            
 [7589] "Stage_I_Adult_Immunoblastic_Lymphoma"                                                                                                                                 
 [7590] "Stage_I_Adult_Lymphoblastic_Lymphoma"                                                                                                                                 
 [7591] "Stage_I_Adult_Burkitt_s_Lymphoma"                                                                                                                                     
 [7592] "Stage_I_High-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                      
 [7593] "Stage_II_Low_Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                      
 [7594] "Stage_I_Ovarian_Germ_Cell_Tumor"                                                                                                                                      
 [7595] "Stage_II_Ovarian_Germ_Cell_Tumor"                                                                                                                                     
 [7596] "Stage_III_Ovarian_Germ_Cell_Tumor"                                                                                                                                    
 [7597] "Stage_IV_Ovarian_Germ_Cell_Tumor"                                                                                                                                     
 [7598] "Recurrent_Ovarian_Germ_Cell_Tumor"                                                                                                                                    
 [7599] "Childhood_Fibrosarcoma"                                                                                                                                               
 [7600] "Childhood_Synovial_Sarcoma"                                                                                                                                           
 [7601] "Malignant_Childhood_Hemangiopericytoma"                                                                                                                               
 [7602] "Childhood_Liposarcoma"                                                                                                                                                
 [7603] "Childhood_Alveolar_Soft_Part_Sarcoma"                                                                                                                                 
 [7604] "Childhood_Leiomyosarcoma"                                                                                                                                             
 [7605] "Childhood_Malignant_Peripheral_Nerve_Sheath_Tumor"                                                                                                                    
 [7606] "Childhood_Epithelioid_Sarcoma"                                                                                                                                        
 [7607] "Childhood_Malignant_Mesenchymoma"                                                                                                                                     
 [7608] "Recurrent_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                               
 [7609] "Squamous_Cell_Carcinoma_of_Unknown_Primary"                                                                                                                           
 [7610] "Undifferentiated_Carcinoma_of_Unknown_Primary"                                                                                                                        
 [7611] "Adult_Solid_Neoplasm"                                                                                                                                                 
 [7612] "Stage_I_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                                 
 [7613] "Stage_II_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                                
 [7614] "Stage_III_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                               
 [7615] "Stage_IV_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                                
 [7616] "Ovarian_Dysgerminoma"                                                                                                                                                 
 [7617] "Ovarian_Yolk_Sac_Tumor"                                                                                                                                               
 [7618] "Ovarian_Embryonal_Carcinoma"                                                                                                                                          
 [7619] "Ovarian_Polyembryoma"                                                                                                                                                 
 [7620] "Ovarian_Teratoma"                                                                                                                                                     
 [7621] "Immature_Ovarian_Teratoma"                                                                                                                                            
 [7622] "Mature_Ovarian_Teratoma"                                                                                                                                              
 [7623] "Ovarian_Monodermal_and_Highly_Specialized_Teratoma"                                                                                                                   
 [7624] "Ovarian_Mixed_Germ_Cell_Tumor"                                                                                                                                        
 [7625] "Stage_II_Small_Lymphocytic_Lymphoma"                                                                                                                                  
 [7626] "Stage_II_Grade_1_Follicular_Lymphoma"                                                                                                                                 
 [7627] "Stage_II_Grade_2_Follicular_Lymphoma"                                                                                                                                 
 [7628] "Stage_II_Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                             
 [7629] "Stage_II_Grade_3_Follicular_Lymphoma"                                                                                                                                 
 [7630] "Stage_II_Adult_Diffuse_Small_Cleaved_Cell_Lymphoma"                                                                                                                   
 [7631] "Stage_II_Adult_Diffuse_Mixed_Cell_Lymphoma"                                                                                                                           
 [7632] "Stage_II_Adult_Diffuse_Large_Cell_Lymphoma"                                                                                                                           
 [7633] "Stage_II_High-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                     
 [7634] "Stage_II_Adult_Immunoblastic_Lymphoma"                                                                                                                                
 [7635] "Stage_II_Adult_Lymphoblastic_Lymphoma"                                                                                                                                
 [7636] "Stage_II_Adult_Burkitt_s_Lymphoma"                                                                                                                                    
 [7637] "Stage_III_Low-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                     
 [7638] "Stage_III_Small_Lymphocytic_Lymphoma"                                                                                                                                 
 [7639] "Stage_III_Grade_1_Follicular_Lymphoma"                                                                                                                                
 [7640] "Stage_III_Grade_2_Follicular_Lymphoma"                                                                                                                                
 [7641] "Stage_III_Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                            
 [7642] "Stage_III_Grade_3_Follicular_Lymphoma"                                                                                                                                
 [7643] "Stage_III_Adult_Diffuse_Small_Cleaved_Cell_Lymphoma"                                                                                                                  
 [7644] "Stage_III_Adult_Diffuse_Mixed_Cell_Lymphoma"                                                                                                                          
 [7645] "Stage_III_Adult_Diffuse_Large_Cell_Lymphoma"                                                                                                                          
 [7646] "Stage_III_High-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                    
 [7647] "Stage_III_Adult_Immunoblastic_Lymphoma"                                                                                                                               
 [7648] "Stage_III_Adult_Lymphoblastic_Lymphoma"                                                                                                                               
 [7649] "Stage_III_Adult_Burkitt_s_Lymphoma"                                                                                                                                   
 [7650] "Stage_IV_Low-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                      
 [7651] "Stage_IV_Small_Lymphocytic_Lymphoma"                                                                                                                                  
 [7652] "Stage_IV_Grade_1_Follicular_Lymphoma"                                                                                                                                 
 [7653] "Stage_IV_Grade_2_Follicular_Lymphoma"                                                                                                                                 
 [7654] "Stage_IV_Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                             
 [7655] "Stage_IV_Grade_3_Follicular_Lymphoma"                                                                                                                                 
 [7656] "Stage_IV_Adult_Diffuse_Small_Cleaved_Cell_Lymphoma"                                                                                                                   
 [7657] "Stage_IV_Adult_Diffuse_Mixed_Cell_Lymphoma"                                                                                                                           
 [7658] "Stage_IV_Adult_Diffuse_Large_Cell_Lymphoma"                                                                                                                           
 [7659] "Stage_IV_High-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                     
 [7660] "Stage_IV_Adult_Immunoblastic_Lymphoma"                                                                                                                                
 [7661] "Stage_IV_Adult_Lymphoblastic_Lymphoma"                                                                                                                                
 [7662] "Stage_IV_Adult_Burkitt_s_Lymphoma"                                                                                                                                    
 [7663] "Recurrent_Low-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                     
 [7664] "Recurrent_Small_Lymphocytic_Lymphoma"                                                                                                                                 
 [7665] "Recurrent_Grade_1_Follicular_Lymphoma"                                                                                                                                
 [7666] "Recurrent_Grade_2_Follicular_Lymphoma"                                                                                                                                
 [7667] "Recurrent_Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                            
 [7668] "Recurrent_Grade_3_Follicular_Lymphoma"                                                                                                                                
 [7669] "Recurrent_Adult_Burkitt_s_Lymphoma"                                                                                                                                   
 [7670] "Recurrent_Adult_Diffuse_Mixed_Cell_Lymphoma"                                                                                                                          
 [7671] "Recurrent_Adult_Diffuse_Large_Cell_Lymphoma"                                                                                                                          
 [7672] "Recurrent_High-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                    
 [7673] "Recurrent_Adult_Immunoblastic_Lymphoma"                                                                                                                               
 [7674] "Recurrent_Adult_Lymphoblastic_Lymphoma"                                                                                                                               
 [7675] "Adult_Non-Hodgkin_s_Lymphoma_Grade"                                                                                                                                   
 [7676] "Localized_Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter"                                                                                                 
 [7677] "Regional_Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter"                                                                                                  
 [7678] "Anterior_Tongue_Squamous_Cell_Carcinoma"                                                                                                                              
 [7679] "Hard_Palate_Squamous_Cell_Carcinoma"                                                                                                                                  
 [7680] "Lower_Gingival_Squamous_Cell_Carcinoma"                                                                                                                               
 [7681] "Retromolar_Trigone_Squamous_Cell_Carcinoma"                                                                                                                           
 [7682] "Upper_Gingival_Squamous_Cell_Carcinoma"                                                                                                                               
 [7683] "Oral_Cavity_Verrucous_Carcinoma"                                                                                                                                      
 [7684] "Buccal_Mucosa_Verrucous_Carcinoma"                                                                                                                                    
 [7685] "Lower_Gingival_Verrucous_Carcinoma"                                                                                                                                   
 [7686] "Oral_Cavity_Mucoepidermoid_Carcinoma"                                                                                                                                 
 [7687] "Floor_of_Mouth_Mucoepidermoid_Carcinoma"                                                                                                                              
 [7688] "Oral_Cavity_Adenoid_Cystic_Carcinoma"                                                                                                                                 
 [7689] "Floor_of_Mouth_Adenoid_Cystic_Carcinoma"                                                                                                                              
 [7690] "Oropharyngeal_Squamous_Cell_Carcinoma"                                                                                                                                
 [7691] "Posterior_Tongue_Squamous_Cell_Carcinoma"                                                                                                                             
 [7692] "Tonsillar_Squamous_Cell_Carcinoma"                                                                                                                                    
 [7693] "Tonsillar_Undifferentiated_Carcinoma"                                                                                                                                 
 [7694] "Postcricoid_Squamous_Cell_Carcinoma"                                                                                                                                  
 [7695] "Glottis_Squamous_Cell_Carcinoma"                                                                                                                                      
 [7696] "Subglottic_Squamous_Cell_Carcinoma"                                                                                                                                   
 [7697] "Laryngeal_Verrucous_Carcinoma"                                                                                                                                        
 [7698] "Glottis_Verrucous_Carcinoma"                                                                                                                                          
 [7699] "Subglottic_Verrucous_Carcinoma"                                                                                                                                       
 [7700] "Supraglottic_Verrucous_Carcinoma"                                                                                                                                     
 [7701] "Nasal_Cavity_Squamous_Cell_Carcinoma"                                                                                                                                 
 [7702] "Paranasal_Sinus_Squamous_Cell_Carcinoma"                                                                                                                              
 [7703] "Nasal_Cavity_Inverted_Papilloma"                                                                                                                                      
 [7704] "Paranasal_Sinus_Inverted_Papilloma"                                                                                                                                   
 [7705] "Nasal_Cavity_Lethal_Midline_Granuloma"                                                                                                                                
 [7706] "Stage_I_Lip_Basal_Cell_Carcinoma"                                                                                                                                     
 [7707] "Stage_I_Oral_Cavity_Verrucous_Carcinoma"                                                                                                                              
 [7708] "Stage_I_Oral_Cavity_Mucoepidermoid_Carcinoma"                                                                                                                         
 [7709] "Stage_I_Oral_Cavity_Adenoid_Cystic_Carcinoma"                                                                                                                         
 [7710] "Stage_II_Lip_Basal_Cell_Carcinoma"                                                                                                                                    
 [7711] "Stage_II_Oral_Cavity_Verrucous_Carcinoma"                                                                                                                             
 [7712] "Stage_II_Oral_Cavity_Mucoepidermoid_Carcinoma"                                                                                                                        
 [7713] "Stage_II_Oral_Cavity_Adenoid_Cystic_Carcinoma"                                                                                                                        
 [7714] "Stage_III_Lip_Basal_Cell_Carcinoma"                                                                                                                                   
 [7715] "Stage_III_Oral_Cavity_Verrucous_Carcinoma"                                                                                                                            
 [7716] "Stage_III_Oral_Cavity_Mucoepidermoid_Carcinoma"                                                                                                                       
 [7717] "Stage_III_Oral_Cavity_Adenoid_Cystic_Carcinoma"                                                                                                                       
 [7718] "Stage_IV_Lip_Basal_Cell_Carcinoma"                                                                                                                                    
 [7719] "Stage_IV_Oral_Cavity_Verrucous_Carcinoma"                                                                                                                             
 [7720] "Stage_IV_Oral_Cavity_Mucoepidermoid_Carcinoma"                                                                                                                        
 [7721] "Stage_IV_Oral_Cavity_Adenoid_Cystic_Carcinoma"                                                                                                                        
 [7722] "Recurrent_Lip_Basal_Cell_Carcinoma"                                                                                                                                   
 [7723] "Recurrent_Oral_Cavity_Verrucous_Carcinoma"                                                                                                                            
 [7724] "Recurrent_Oral_Cavity_Mucoepidermoid_Carcinoma"                                                                                                                       
 [7725] "Recurrent_Oral_Cavity_Adenoid_Cystic_Carcinoma"                                                                                                                       
 [7726] "Stage_I_Oropharyngeal_Squamous_Cell_Carcinoma"                                                                                                                        
 [7727] "Stage_II_Oropharyngeal_Squamous_Cell_Carcinoma"                                                                                                                       
 [7728] "Stage_III_Oropharyngeal_Squamous_Cell_Carcinoma"                                                                                                                      
 [7729] "Stage_IV_Oropharyngeal_Squamous_Cell_Carcinoma"                                                                                                                       
 [7730] "Recurrent_Oropharyngeal_Squamous_Cell_Carcinoma"                                                                                                                      
 [7731] "Stage_I_Nasopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                       
 [7732] "Stage_I_Nasopharyngeal_Undifferentiated_Carcinoma"                                                                                                                    
 [7733] "Stage_II_Nasopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                      
 [7734] "Stage_II_Nasopharyngeal_Undifferentiated_Carcinoma"                                                                                                                   
 [7735] "Stage_III_Nasopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                     
 [7736] "Stage_III_Nasopharyngeal_Undifferentiated_Carcinoma"                                                                                                                  
 [7737] "Stage_IV_Nasopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                      
 [7738] "Stage_IV_Nasopharyngeal_Undifferentiated_Carcinoma"                                                                                                                   
 [7739] "Recurrent_Nasopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                     
 [7740] "Recurrent_Nasopharyngeal_Undifferentiated_Carcinoma"                                                                                                                  
 [7741] "Stage_I_Hypopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                       
 [7742] "Stage_II_Hypopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                      
 [7743] "Stage_III_Hypopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                     
 [7744] "Stage_IV_Hypopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                      
 [7745] "Recurrent_Hypopharyngeal_Squamous_Cell_Carcinoma"                                                                                                                     
 [7746] "Stage_I_Laryngeal_Squamous_Cell_Carcinoma"                                                                                                                            
 [7747] "Stage_I_Laryngeal_Verrucous_Carcinoma"                                                                                                                                
 [7748] "Stage_II_Laryngeal_Squamous_Cell_Carcinoma"                                                                                                                           
 [7749] "Stage_II_Laryngeal_Verrucous_Carcinoma"                                                                                                                               
 [7750] "Stage_III_Laryngeal_Squamous_Cell_Carcinoma"                                                                                                                          
 [7751] "Stage_III_Laryngeal_Verrucous_Carcinoma"                                                                                                                              
 [7752] "Stage_IV_Laryngeal_Squamous_Cell_Carcinoma"                                                                                                                           
 [7753] "Stage_IV_Laryngeal_Verrucous_Carcinoma"                                                                                                                               
 [7754] "Recurrent_Laryngeal_Squamous_Cell_Carcinoma"                                                                                                                          
 [7755] "Recurrent_Laryngeal_Verrucous_Carcinoma"                                                                                                                              
 [7756] "Stage_I_Adult_T-Cell_Lymphoma_Leukemia"                                                                                                                               
 [7757] "Stage_II_Adult_T-Cell_Lymphoma_Leukemia"                                                                                                                              
 [7758] "Stage_III_Adult_T-Cell_Lymphoma_Leukemia"                                                                                                                             
 [7759] "Stage_IV_Adult_T-Cell_Lymphoma_Leukemia"                                                                                                                              
 [7760] "Recurrent_Adult_T-Cell_Lymphoma_Leukemia"                                                                                                                             
 [7761] "Therapy-Related_Acute_Myeloid_Leukemia"                                                                                                                               
 [7762] "de_novo_Myelodysplastic_Syndrome"                                                                                                                                     
 [7763] "Recurrent_Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter"                                                                                                 
 [7764] "Anal_Cloacogenic_Carcinoma"                                                                                                                                           
 [7765] "Anal_Basaloid_Carcinoma"                                                                                                                                              
 [7766] "Adult_Anaplastic_Astrocytoma"                                                                                                                                         
 [7767] "Stage_I_Uterine_Sarcoma"                                                                                                                                              
 [7768] "Stage_II_Uterine_Sarcoma"                                                                                                                                             
 [7769] "Stage_III_Uterine_Sarcoma"                                                                                                                                            
 [7770] "Recurrent_Uterine_Sarcoma"                                                                                                                                            
 [7771] "Adult_Acute_Differentiated_Monocytic_Leukemia"                                                                                                                        
 [7772] "Childhood_Meningioma"                                                                                                                                                 
 [7773] "Adult_Primary_Cholangiocarcinoma"                                                                                                                                     
 [7774] "Ovarian_Sarcoma"                                                                                                                                                      
 [7775] "Adult_Anaplastic_Ependymoma"                                                                                                                                          
 [7776] "Adult_Anaplastic_Oligodendroglioma"                                                                                                                                   
 [7777] "Mixed_Astrocytoma-Ependymoma"                                                                                                                                         
 [7778] "Mixed_Astrocytoma-Ependymoma-Oligodendroglioma"                                                                                                                       
 [7779] "Adult_Pineal_Parenchymal_Cell_Neoplasm"                                                                                                                               
 [7780] "Pineal_Gland_Astrocytoma"                                                                                                                                             
 [7781] "Adult_Anaplastic_Malignant_Meningioma"                                                                                                                                
 [7782] "Skin_Integrity_Changes_Secondary_to_Cutaneous_Metastases"                                                                                                             
 [7783] "Localized_Unresectable_Neuroblastoma"                                                                                                                                 
 [7784] "Cancer-Related_Condition"                                                                                                                                             
 [7785] "Long-Term_Effects_Secondary_to_Cancer_Therapy_in_Children"                                                                                                            
 [7786] "Perioperative_Postoperative_Complications"                                                                                                                            
 [7787] "Poor_Vascular_Access"                                                                                                                                                 
 [7788] "Sexual_Dysfunction_and_Infertility"                                                                                                                                   
 [7789] "Skin_Reactions_Secondary_to_Radiation_Therapy"                                                                                                                        
 [7790] "AIDS-Related_Primary_Central_Nervous_System_Lymphoma"                                                                                                                 
 [7791] "AIDS_Related_Immunoblastic_Lymphoma"                                                                                                                                  
 [7792] "ENV_Gene"                                                                                                                                                             
 [7793] "Bilateral_Breast_Carcinoma"                                                                                                                                           
 [7794] "Known_Bone_Marrow_Involvement"                                                                                                                                        
 [7795] "Adult_Infiltrating_Astrocytoma"                                                                                                                                       
 [7796] "Adult_Ependymoblastoma"                                                                                                                                               
 [7797] "Adult_Pineocytoma"                                                                                                                                                    
 [7798] "Adult_Pineoblastoma"                                                                                                                                                  
 [7799] "Adult_Papillary_Meningioma"                                                                                                                                           
 [7800] "Pancreatic_Adenocarcinoma"                                                                                                                                            
 [7801] "Respiratory_Papilloma"                                                                                                                                                
 [7802] "AIDS-Related_Diffuse_Mixed_Cell_Lymphoma"                                                                                                                             
 [7803] "AIDS-Related_Diffuse_Small_Cleaved_Cell_Lymphoma"                                                                                                                     
 [7804] "AIDS-Related_Lymphoblastic_Lymphoma"                                                                                                                                  
 [7805] "Primary_Systemic_Amyloidosis"                                                                                                                                         
 [7806] "Desmoplastic_Small_Round_Cell_Tumor"                                                                                                                                  
 [7807] "Veno-Occlusive_Disease"                                                                                                                                               
 [7808] "Graft-Versus-Tumor_Induction"                                                                                                                                         
 [7809] "Adult_Acute_Myeloid_Leukemia_Minimally_Differentiated"                                                                                                                
 [7810] "Childhood_Acute_Myeloid_Leukemia_Minimally_Differentiated"                                                                                                            
 [7811] "Stage_I_Childhood_Large_Cell_Lymphoma"                                                                                                                                
 [7812] "Stage_II_Childhood_Large_Cell_Lymphoma"                                                                                                                               
 [7813] "Stage_III_Childhood_Large_Cell_Lymphoma"                                                                                                                              
 [7814] "Stage_IV_Childhood_Large_Cell_Lymphoma"                                                                                                                               
 [7815] "Recurrent_Childhood_Large_Cell_Lymphoma"                                                                                                                              
 [7816] "Childhood_Large_Cell_Lymphoma"                                                                                                                                        
 [7817] "Fibrous_Polyp"                                                                                                                                                        
 [7818] "Leptomeningeal_Sarcoma"                                                                                                                                               
 [7819] "Stage_I_Lymphoma"                                                                                                                                                     
 [7820] "Stage_II_Lymphoma"                                                                                                                                                    
 [7821] "Stage_III_Lymphoma"                                                                                                                                                   
 [7822] "Stage_IV_Lymphoma"                                                                                                                                                    
 [7823] "Intracranial_Colloid_Cyst"                                                                                                                                            
 [7824] "Amyloid_Neoplasm"                                                                                                                                                     
 [7825] "Triploidy"                                                                                                                                                            
 [7826] "Dicentric_Chromosome"                                                                                                                                                 
 [7827] "Cytologic_Atypia"                                                                                                                                                     
 [7828] "Mild_Cytologic_Atypia"                                                                                                                                                
 [7829] "Moderate_Cytologic_Atypia"                                                                                                                                            
 [7830] "Severe_Cytologic_Atypia"                                                                                                                                              
 [7831] "Squamous_Cell_Atypia"                                                                                                                                                 
 [7832] "Mild_Squamous_Cell_Atypia"                                                                                                                                            
 [7833] "Moderate_Squamous_Cell_Atypia"                                                                                                                                        
 [7834] "Severe_Squamous_Cell_Atypia"                                                                                                                                          
 [7835] "Squamous_Cell_Intraepithelial_Neoplasia"                                                                                                                              
 [7836] "Low_Grade_Squamous_Intraepithelial_Neoplasia"                                                                                                                         
 [7837] "High-Grade_Squamous_Intraepithelial_Neoplasia"                                                                                                                        
 [7838] "Columnar_Cell_Atypia"                                                                                                                                                 
 [7839] "Mild_Columnar_Cell_Atypia"                                                                                                                                            
 [7840] "Moderate_Columnar_Cell_Atypia"                                                                                                                                        
 [7841] "Severe_Columnar_Cell_Atypia"                                                                                                                                          
 [7842] "Glandular_Cell_Atypia"                                                                                                                                                
 [7843] "Mild_Glandular_Cell_Atypia"                                                                                                                                           
 [7844] "Moderate_Glandular_Cell_Atypia"                                                                                                                                       
 [7845] "Severe_Glandular_Cell_Atypia"                                                                                                                                         
 [7846] "Transitional_Cell_Atypia"                                                                                                                                             
 [7847] "Mild_Transitional_Cell_Atypia"                                                                                                                                        
 [7848] "Moderate_Transitional_Cell_Atypia"                                                                                                                                    
 [7849] "Severe_Transitional_Cell_Atypia"                                                                                                                                      
 [7850] "Post-Radiation_Cytologic_Changes_with_Dysplasia"                                                                                                                      
 [7851] "Atypia_Suspicious_for_Malignancy"                                                                                                                                     
 [7852] "Koilocytotic_Atypia"                                                                                                                                                  
 [7853] "Mild_Koilocytotic_Atypia"                                                                                                                                             
 [7854] "Moderate_Koilocytotic_Atypia"                                                                                                                                         
 [7855] "Severe_Koilocytotic_Atypia"                                                                                                                                           
 [7856] "Atypical_Hyperplasia"                                                                                                                                                 
 [7857] "Atypical_Glandular_Hyperplasia"                                                                                                                                       
 [7858] "Atypical_Squamous_Metaplasia"                                                                                                                                         
 [7859] "Glandular_Metaplasia"                                                                                                                                                 
 [7860] "Apocrine_Metaplasia"                                                                                                                                                  
 [7861] "Intestinal_Metaplasia"                                                                                                                                                
 [7862] "Gastric_Metaplasia"                                                                                                                                                   
 [7863] "Mild_Dysplasia"                                                                                                                                                       
 [7864] "Moderate_Dysplasia"                                                                                                                                                   
 [7865] "Severe_Dysplasia"                                                                                                                                                     
 [7866] "Fibrocystic_Disease_Proliferative_Type_with_Atypia"                                                                                                                   
 [7867] "Intraepithelial_Neoplasia"                                                                                                                                            
 [7868] "Low_Grade_Intraepithelial_Neoplasia"                                                                                                                                  
 [7869] "Grade_II_Intraepithelial_Neoplasia"                                                                                                                                   
 [7870] "Grade_III_Intraepithelial_Neoplasia"                                                                                                                                  
 [7871] "Fibrous_Hamartoma"                                                                                                                                                    
 [7872] "Collagen_Nevus"                                                                                                                                                       
 [7873] "Hamartomatous_Polyp"                                                                                                                                                  
 [7874] "Lymphangiomatosis"                                                                                                                                                    
 [7875] "Bowenoid_Papulosis"                                                                                                                                                   
 [7876] "Adenocarcinoma_in_situ_in_Villous_Adenoma"                                                                                                                            
 [7877] "Papillary_Serous_Cystadenocarcinoma"                                                                                                                                  
 [7878] "Giant_Cell_Fibrous_Histiocytoma"                                                                                                                                      
 [7879] "Gigantiform_Cementoma"                                                                                                                                                
 [7880] "Anaplastic_Choroid_Plexus_Papilloma"                                                                                                                                  
 [7881] "Renal_Adenoma"                                                                                                                                                        
 [7882] "Endometrial_Stromal_Neoplasm"                                                                                                                                         
 [7883] "Malignant_Myoepithelioma"                                                                                                                                             
 [7884] "Childhood_Cerebral_Diffuse_Astrocytoma"                                                                                                                               
 [7885] "Functioning_Pituitary_Gland_Adenoma"                                                                                                                                  
 [7886] "Recurrent_Childhood_Cerebellar_Astrocytoma"                                                                                                                           
 [7887] "Anal_Leukoplakia"                                                                                                                                                     
 [7888] "Squamous_Metaplasia_of_Bladder"                                                                                                                                       
 [7889] "Upper_Gingival_Carcinoma"                                                                                                                                             
 [7890] "Lower_Gingival_Carcinoma"                                                                                                                                             
 [7891] "Hard_Palate_Carcinoma"                                                                                                                                                
 [7892] "Soft_Palate_Carcinoma"                                                                                                                                                
 [7893] "Submandibular_Gland_Carcinoma"                                                                                                                                        
 [7894] "Sublingual_Gland_Carcinoma"                                                                                                                                           
 [7895] "Gastric_Fundus_Carcinoma"                                                                                                                                             
 [7896] "Gastric_Body_Carcinoma"                                                                                                                                               
 [7897] "Carcinoma_in_situ_of_the_Antrum"                                                                                                                                      
 [7898] "Jejunal_Neoplasm"                                                                                                                                                     
 [7899] "Fibrohistiocytic_Neoplasm"                                                                                                                                            
 [7900] "Malignant_Ovarian_Granulosa_Cell_Tumor"                                                                                                                               
 [7901] "Renal_Pelvis_Neoplasm"                                                                                                                                                
 [7902] "Benign_Choroid_Plexus_Neoplasm"                                                                                                                                       
 [7903] "Posterior_Tongue_Carcinoma"                                                                                                                                           
 [7904] "Malignant_Sternal_Neoplasm"                                                                                                                                           
 [7905] "Malignant_Sebaceous_Neoplasm"                                                                                                                                         
 [7906] "Breast_Melanoma"                                                                                                                                                      
 [7907] "Metastatic_Neoplasm_to_the_Colon"                                                                                                                                     
 [7908] "Stage_IV_Rectal_Cancer"                                                                                                                                               
 [7909] "Benign_Supraglottis_Neoplasm"                                                                                                                                         
 [7910] "Benign_Pancreatic_Duct_Neoplasm"                                                                                                                                      
 [7911] "Benign_Sternal_Neoplasm"                                                                                                                                              
 [7912] "Benign_Ear_Neoplasm"                                                                                                                                                  
 [7913] "Benign_Bartholin_s_Gland_Neoplasm"                                                                                                                                    
 [7914] "Dysplastic_Cerebellar_Gangliocytoma"                                                                                                                                  
 [7915] "Diffuse_Malignant_Mesothelioma"                                                                                                                                       
 [7916] "Uterine_Cervix_Condyloma_Acuminatum"                                                                                                                                  
 [7917] "Cementifying_Fibroma"                                                                                                                                                 
 [7918] "Stage_0_Melanoma_of_the_Skin"                                                                                                                                         
 [7919] "Leukoplakia_of_Buccal_Mucosa"                                                                                                                                         
 [7920] "Diffuse_Neurofibroma"                                                                                                                                                 
 [7921] "Vagus_Nerve_Paraganglioma"                                                                                                                                            
 [7922] "Tympanic_Paraganglioma"                                                                                                                                               
 [7923] "Papillary_Epithelial_Neoplasm"                                                                                                                                        
 [7924] "Ovarian_Papillary_Neoplasm"                                                                                                                                           
 [7925] "Ovarian_Serous_Neoplasm"                                                                                                                                              
 [7926] "Borderline_Ovarian_Serous_Surface_Papilloma"                                                                                                                          
 [7927] "Microcalcification"                                                                                                                                                   
 [7928] "Atypical_Squamous_Cell_of_Undetermined_Significance"                                                                                                                  
 [7929] "Atypical_Glandular_Cells_of_Uncertain_Significance"                                                                                                                   
 [7930] "Atypical_Ductal_Breast_Hyperplasia"                                                                                                                                   
 [7931] "Atypical_Gastric_Metaplasia"                                                                                                                                          
 [7932] "Ectopic_Renin_Secretion"                                                                                                                                              
 [7933] "Ectopic_Growth_Hormone_Secretion"                                                                                                                                     
 [7934] "Ectopic_Prolactin_Secretion"                                                                                                                                          
 [7935] "Ectopic_Aldosterone_Secretion"                                                                                                                                        
 [7936] "Ectopic_Calcitonin_Secretion"                                                                                                                                         
 [7937] "Ectopic_Chorionic_Gonadotropin_Secretion"                                                                                                                             
 [7938] "Atypical_Cells_of_Uncertain_Significance"                                                                                                                             
 [7939] "Atypical_Endocervical_Glandular_Cells_of_Uncertain_Significance"                                                                                                      
 [7940] "Atypical_Endometrial_Glandular_Cells_of_Uncertain_Significance"                                                                                                       
 [7941] "Mesenchymal_Cell_Atypia"                                                                                                                                              
 [7942] "Smooth_Muscle_Cell_Atypia"                                                                                                                                            
 [7943] "Striated_Muscle_Cell_Atypia"                                                                                                                                          
 [7944] "Fibroblastic_Cell_Atypia"                                                                                                                                             
 [7945] "Atypical_Apocrine_Metaplasia"                                                                                                                                         
 [7946] "Focal_Dysplasia"                                                                                                                                                      
 [7947] "Diffuse_Dysplasia"                                                                                                                                                    
 [7948] "Hepatosplenic_T-Cell_Lymphoma"                                                                                                                                        
 [7949] "Acute_Myeloid_Leukemia_Minimally_Differentiated"                                                                                                                      
 [7950] "Tibial_Adamantinoma"                                                                                                                                                  
 [7951] "Palate_Carcinoma"                                                                                                                                                     
 [7952] "Stage_I_Indolent_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                        
 [7953] "Stage_I_Mantle_Cell_Lymphoma"                                                                                                                                         
 [7954] "Stage_II_Contiguous_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                     
 [7955] "Stage_II_Contiguous_Adult_Indolent_Non-Hodgkin_s_Lymphoma"                                                                                                            
 [7956] "Stage_II_Grade_1_Contiguous_Follicular_Lymphoma"                                                                                                                      
 [7957] "Stage_II_Grade_2_Contiguous_Follicular_Lymphoma"                                                                                                                      
 [7958] "Stage_II_Grade_3_Contiguous_Follicular_Lymphoma"                                                                                                                      
 [7959] "Stage_II_Contiguous_Adult_Diffuse_Small_Cleaved_Cell_Lymphoma"                                                                                                        
 [7960] "Stage_II_Contiguous_Adult_Aggressive_Non-Hodgkin_s_Lymphoma"                                                                                                          
 [7961] "Stage_II_Contiguous_Mantle_Cell_Lymphoma"                                                                                                                             
 [7962] "Stage_II_Contiguous_Adult_Diffuse_Mixed_Cell_Lymphoma"                                                                                                                
 [7963] "Stage_II_Contiguous_Adult_Diffuse_Large_Cell_Lymphoma"                                                                                                                
 [7964] "Stage_II_Contiguous_Adult_Lymphoblastic_Lymphoma"                                                                                                                     
 [7965] "Stage_II_Non-Contiguous_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                 
 [7966] "Stage_II_Non-Contiguous_Adult_Indolent_Non-Hodgkin_s_Lymphoma"                                                                                                        
 [7967] "Stage_II_Non-Contiguous_Aggressive_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                      
 [7968] "Stage_II_Non-Contiguous_Adult_Diffuse_Large_Cell_Lymphoma"                                                                                                            
 [7969] "Stage_II_Non-Contiguous_Adult_Lymphoblastic_Lymphoma"                                                                                                                 
 [7970] "Stage_III_Indolent_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                      
 [7971] "Stage_III_Mantle_Cell_Lymphoma"                                                                                                                                       
 [7972] "Stage_III_Aggressive_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                    
 [7973] "Stage_IV_Indolent_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                       
 [7974] "Stage_IV_Mantle_Cell_Lymphoma"                                                                                                                                        
 [7975] "Stage_IV_Aggressive_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                     
 [7976] "Recurrent_Indolent_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                      
 [7977] "Recurrent_Mantle_Cell_Lymphoma"                                                                                                                                       
 [7978] "Recurrent_Aggressive_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                    
 [7979] "Indolent_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                                
 [7980] "Aggressive_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                              
 [7981] "Hereditary_Breast_and_Ovarian_Cancer_Syndrome"                                                                                                                        
 [7982] "Hereditary_Non-Polyposis_Colon_Cancer"                                                                                                                                
 [7983] "Hereditary_Retinoblastoma_RB1"                                                                                                                                        
 [7984] "Hereditary_Wilms_Tumor"                                                                                                                                               
 [7985] "Neurofibromatosis_1_and_2_NF1_and_NF2"                                                                                                                                
 [7986] "Hereditary_Melanoma_1_and_2_CDKN2_CDK4"                                                                                                                               
 [7987] "Loss_Grief_and_Bereavement"                                                                                                                                           
 [7988] "Bilateral_Carcinoma"                                                                                                                                                  
 [7989] "Brain_Stem_Glioma"                                                                                                                                                    
 [7990] "chronic_lymphoblastic_lymphoma"                                                                                                                                       
 [7991] "Evaluable_Disease"                                                                                                                                                    
 [7992] "Indolent_Non-Hodgkin_s_Lymphoma"                                                                                                                                      
 [7993] "Invasive_Malignant_Neoplasm"                                                                                                                                          
 [7994] "Malignant_Leptomeningeal_Neoplasm"                                                                                                                                    
 [7995] "Measurable_Disease"                                                                                                                                                   
 [7996] "Positive_Axillary_Lymph_Node"                                                                                                                                         
 [7997] "Primary_Neoplasm"                                                                                                                                                     
 [7998] "Progressive_Neoplastic_Disease"                                                                                                                                       
 [7999] "Refractory_Carcinoma"                                                                                                                                                 
 [8000] "Cancer_with_Regional_Lymph_Node_Involvement"                                                                                                                          
 [8001] "Stage_I_Colorectal_Cancer"                                                                                                                                            
 [8002] "Stage_II_Colorectal_Cancer"                                                                                                                                           
 [8003] "Stage_III_Colorectal_Cancer"                                                                                                                                          
 [8004] "Stage_IV_Colorectal_Cancer"                                                                                                                                           
 [8005] "Stage_I_Hodgkin_s_Lymphoma"                                                                                                                                           
 [8006] "Stage_II_Hodgkin_s_Lymphoma"                                                                                                                                          
 [8007] "Stage_IV_Hodgkin_s_Lymphoma"                                                                                                                                          
 [8008] "Stage_I_Non-Hodgkin_s_Lymphoma"                                                                                                                                       
 [8009] "Stage_II_Non-Hodgkin_s_Lymphoma"                                                                                                                                      
 [8010] "Stage_III_Non-Hodgkin_s_Lymphoma"                                                                                                                                     
 [8011] "Stage_IV_Non-Hodgkin_s_Lymphoma"                                                                                                                                      
 [8012] "Locally_Advanced_Malignant_Neoplasm"                                                                                                                                  
 [8013] "Benign_Sebaceous_Neoplasm"                                                                                                                                            
 [8014] "Metastasis_to_the_Sternum"                                                                                                                                            
 [8015] "Metastatic_Neoplasm_to_the_Neck"                                                                                                                                      
 [8016] "Benign_Chest_Wall_Neoplasm"                                                                                                                                           
 [8017] "Metastasis_to_the_Chest_Wall"                                                                                                                                         
 [8018] "Benign_Respiratory_Tract_Neoplasm"                                                                                                                                    
 [8019] "Benign_Paranasal_Sinus_Neoplasm"                                                                                                                                      
 [8020] "Stage_IV_Hypopharyngeal_Carcinoma"                                                                                                                                    
 [8021] "Benign_Epicardial_Neoplasm"                                                                                                                                           
 [8022] "Benign_Pericardial_Neoplasm"                                                                                                                                          
 [8023] "Benign_Blood_Vessel_Neoplasm"                                                                                                                                         
 [8024] "Malignant_Blood_Vessel_Neoplasm"                                                                                                                                      
 [8025] "Benign_Great_Vessel_Neoplasm"                                                                                                                                         
 [8026] "Subcutaneous_Tissue_Hemangioma"                                                                                                                                       
 [8027] "Splenic_Hemangioma"                                                                                                                                                   
 [8028] "Metastatic_Neoplasm_to_the_Lip"                                                                                                                                       
 [8029] "Metastatic_Neoplasm_to_the_Pancreas"                                                                                                                                  
 [8030] "Metastatic_Neoplasm_to_the_Epididymis"                                                                                                                                
 [8031] "Benign_Placental_Neoplasm"                                                                                                                                            
 [8032] "Metastatic_Neoplasm_to_the_Placenta"                                                                                                                                  
 [8033] "Metastasis_to_the_Nervous_System"                                                                                                                                     
 [8034] "Benign_Cerebral_Neoplasm"                                                                                                                                             
 [8035] "Benign_Brain_Stem_Neoplasm"                                                                                                                                           
 [8036] "Metastatic_Neoplasm_to_the_Brain_Stem"                                                                                                                                
 [8037] "Metastasis_to_the_Ciliary_Body"                                                                                                                                       
 [8038] "Metastatic_Neoplasm_to_the_Choroid"                                                                                                                                   
 [8039] "Metastatic_Neoplasm_to_the_Retina"                                                                                                                                    
 [8040] "Metastatic_Neoplasm_to_the_Orbit"                                                                                                                                     
 [8041] "Metastatic_Neoplasm_to_the_Parathyroid"                                                                                                                               
 [8042] "Malignant_Paraganglionic_Neoplasm"                                                                                                                                    
 [8043] "Erythroleukemia_in_Remission"                                                                                                                                         
 [8044] "Malignant_Male_Reproductive_System_Neoplasm"                                                                                                                          
 [8045] "Ocular_Melanoma"                                                                                                                                                      
 [8046] "Malignant_Bone_Fibrous_Histiocytoma"                                                                                                                                  
 [8047] "Stage_II_Adult_Contiguous_Immunoblastic_Lymphoma"                                                                                                                     
 [8048] "Stage_II_Adult_Non-Contiguous_Immunoblastic_Lymphoma"                                                                                                                 
 [8049] "Metastatic_Neoplasm_of_Unknown_Primary_Origin"                                                                                                                        
 [8050] "Visual_Pathway_Glioma"                                                                                                                                                
 [8051] "Adult_Choroid_Plexus_Neoplasm"                                                                                                                                        
 [8052] "Stage_IA_Adult_Soft_Tissue_Sarcoma"                                                                                                                                   
 [8053] "Stage_IB_Adult_Soft_Tissue_Sarcoma"                                                                                                                                   
 [8054] "Stage_IIA_Adult_Soft_Tissue_Sarcoma"                                                                                                                                  
 [8055] "Stage_IIB_Adult_Soft_Tissue_Sarcoma"                                                                                                                                  
 [8056] "Stage_IIC_Adult_Soft_Tissue_Sarcoma"                                                                                                                                  
 [8057] "Refractory_Cytopenia_with_Multilineage_Dysplasia"                                                                                                                     
 [8058] "Stage_IVB_Pancreatic_Cancer"                                                                                                                                          
 [8059] "Localized_Malignant_Neoplasm"                                                                                                                                         
 [8060] "Infiltrating_Cervical_Carcinoma"                                                                                                                                      
 [8061] "Childhood_Ependymoma"                                                                                                                                                 
 [8062] "Recurrent_Childhood_Ependymoma"                                                                                                                                       
 [8063] "Stage_IB_Soft_Tissue_Sarcoma"                                                                                                                                         
 [8064] "Stage_IIA_Soft_Tissue_Sarcoma"                                                                                                                                        
 [8065] "Stage_IIB_Soft_Tissue_Sarcoma"                                                                                                                                        
 [8066] "Stage_IA_Soft_Tissue_Sarcoma"                                                                                                                                         
 [8067] "Stage_IIC_Soft_Tissue_Sarcoma"                                                                                                                                        
 [8068] "Stage_III_Soft_Tissue_Sarcoma"                                                                                                                                        
 [8069] "Stage_IV_Soft_Tissue_Sarcoma"                                                                                                                                         
 [8070] "Precancerous_Polyp"                                                                                                                                                   
 [8071] "Childhood_Ovarian_Germ_Cell_Tumor"                                                                                                                                    
 [8072] "Acute_Myelomonocytic_Leukemia_in_Remission"                                                                                                                           
 [8073] "Lymphocyte_Predominant_Type_Hodgkin_s_Disease"                                                                                                                        
 [8074] "Testicular_Germ_Cell_Neoplasm"                                                                                                                                        
 [8075] "Benign_Chondrogenic_Neoplasm"                                                                                                                                         
 [8076] "Leukemic_Phase_of_Lymphoma"                                                                                                                                           
 [8077] "Postcricoid_Carcinoma"                                                                                                                                                
 [8078] "Vulvar_Angiokeratoma"                                                                                                                                                 
 [8079] "Retro-Orbit_Neoplasm"                                                                                                                                                 
 [8080] "Aggravated_Epilepsy"                                                                                                                                                  
 [8081] "Stage_II_Extragonadal_Primary_Mixed_Germ_Cell_Tumor"                                                                                                                  
 [8082] "Retinal_Melanoma"                                                                                                                                                     
 [8083] "Pleomorphic_Adenoma"                                                                                                                                                  
 [8084] "Renal_Pelvis_Papillary_Neoplasm"                                                                                                                                      
 [8085] "Recurrent_Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia"                                                                                                 
 [8086] "Anaplastic_Malignant_Intraspinal_Meningioma"                                                                                                                          
 [8087] "Stage_II_Testicular_Choriocarcinoma"                                                                                                                                  
 [8088] "Recurrent_Inflammatory_Breast_Carcinoma"                                                                                                                              
 [8089] "Congenital_Epilepsy"                                                                                                                                                  
 [8090] "Malignant_Hepato-Biliary_Neoplasm"                                                                                                                                    
 [8091] "Metastatic_Neoplasm_to_the_Adrenal_Gland"                                                                                                                             
 [8092] "Benign_Peritoneal_Neoplasm"                                                                                                                                           
 [8093] "Myeloid_Sarcoma_in_Remission"                                                                                                                                         
 [8094] "Hepato-Biliary_Neoplasm"                                                                                                                                              
 [8095] "Metastatic_Neoplasm_to_the_Abdominal_Cavity"                                                                                                                          
 [8096] "Chronic_Myelomonocytic_Leukemia_in_Remission"                                                                                                                         
 [8097] "Pure_Erythroid_Leukemia_in_Remission"                                                                                                                                 
 [8098] "Intracranial_Tumor_Hemorrhage"                                                                                                                                        
 [8099] "Recurrent_Colorectal_Cancer"                                                                                                                                          
 [8100] "Stage_IV_Gastric_Cancer_with_Metastasis"                                                                                                                              
 [8101] "Recurrent_Esophageal_Adenocarcinoma"                                                                                                                                  
 [8102] "Stage_II_Esophageal_Adenocarcinoma"                                                                                                                                   
 [8103] "Stage_0_Esophageal_Adenocarcinoma"                                                                                                                                    
 [8104] "Stage_I_Esophageal_Adenocarcinoma"                                                                                                                                    
 [8105] "Stage_III_Esophageal_Adenocarcinoma"                                                                                                                                  
 [8106] "Stage_IV_Esophageal_Adenocarcinoma"                                                                                                                                   
 [8107] "Recurrent_Esophageal_Squamous_Cell_Carcinoma"                                                                                                                         
 [8108] "Recurrent_Rectosigmoid_Carcinoma"                                                                                                                                     
 [8109] "Stage_III_Rectosigmoid_Cancer"                                                                                                                                        
 [8110] "Stage_IV_Rectosigmoid_Cancer"                                                                                                                                         
 [8111] "Metastatic_Small_Intestinal_Carcinoma"                                                                                                                                
 [8112] "Unresectable_Small_Intestinal_Cancer"                                                                                                                                 
 [8113] "Resectable_Small_Intestinal_Cancer"                                                                                                                                   
 [8114] "Resectable_Extrahepatic_Bile_Duct_Carcinoma"                                                                                                                          
 [8115] "Unresectable_Hepatoblastoma"                                                                                                                                          
 [8116] "Resectable_Hepatoblastoma"                                                                                                                                            
 [8117] "Recurrent_Hepatoblastoma"                                                                                                                                             
 [8118] "Precursor_B_Lymphoblastic_Leukemia"                                                                                                                                   
 [8119] "Recurrent_Chronic_Lymphocytic_Leukemia"                                                                                                                               
 [8120] "Stage_IV_Chronic_Lymphocytic_Leukemia"                                                                                                                                
 [8121] "Aggressive_NK-Cell_Leukemia"                                                                                                                                          
 [8122] "Myelodysplastic_Syndrome_Unclassifiable"                                                                                                                              
 [8123] "Recurrent_Lymphocyte_Depleted_Hodgkin_s_Lymphoma"                                                                                                                     
 [8124] "Refractory_Lymphocyte_Depleted_Hodgkin_s_Lymphoma"                                                                                                                    
 [8125] "Stage_IV_Lymphocyte_Depleted_Hodgkin_s_Lymphoma"                                                                                                                      
 [8126] "Refractory_Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia"                                                                                                
 [8127] "Stage_I_Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia"                                                                                                   
 [8128] "Stage_II_Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia"                                                                                                  
 [8129] "Stage_III_Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia"                                                                                                 
 [8130] "Stage_IV_Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia"                                                                                                  
 [8131] "Refractory_Adult_T-Cell_Lymphoma_Leukemia"                                                                                                                            
 [8132] "Refractory_Anaplastic_Large_Cell_Lymphoma"                                                                                                                            
 [8133] "Stage_I_Anaplastic_Large_Cell_Lymphoma"                                                                                                                               
 [8134] "Stage_II_Anaplastic_Large_Cell_Lymphoma"                                                                                                                              
 [8135] "Stage_III_Anaplastic_Large_Cell_Lymphoma"                                                                                                                             
 [8136] "Stage_IV_Anaplastic_Large_Cell_Lymphoma"                                                                                                                              
 [8137] "Recurrent_T-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                              
 [8138] "Refractory_T-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                             
 [8139] "Stage_I_T-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                                
 [8140] "Stage_II_T-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                               
 [8141] "Stage_III_T-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                              
 [8142] "Stage_IV_T-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                               
 [8143] "Refractory_Nasal_Type_Extranodal_NK_T-Cell_Lymphoma"                                                                                                                  
 [8144] "Stage_I_Nasal_Type_NK_T-Cell_Lymphoma"                                                                                                                                
 [8145] "Refractory_Angioimmunoblastic_T-cell_Lymphoma"                                                                                                                        
 [8146] "Stage_I_Angioimmunoblastic_T-cell_Lymphoma"                                                                                                                           
 [8147] "Stage_II_Nasal_Type_NK_T-Cell_Lymphoma"                                                                                                                               
 [8148] "Stage_III_Nasal_Type_NK_T-Cell_Lymphoma"                                                                                                                              
 [8149] "Stage_IV_Nasal_Type_NK_T-Cell_Lymphoma"                                                                                                                               
 [8150] "Recurrent_Angioimmunoblastic_T-cell_Lymphoma"                                                                                                                         
 [8151] "Stage_II_Angioimmunoblastic_T-cell_Lymphoma"                                                                                                                          
 [8152] "Stage_III_Angioimmunoblastic_T-cell_Lymphoma"                                                                                                                         
 [8153] "Stage_IV_Angioimmunoblastic_T-cell_Lymphoma"                                                                                                                          
 [8154] "Recurrent_Enteropathy-type_T-Cell_Lymphoma"                                                                                                                           
 [8155] "Refractory_Enteropathy-type_T-Cell_Lymphoma"                                                                                                                          
 [8156] "Stage_I_Enteropathy-type_T-Cell_Lymphoma"                                                                                                                             
 [8157] "Stage_II_Enteropathy-type_T-Cell_Lymphoma"                                                                                                                            
 [8158] "Stage_III_Enteropathy-type_T-Cell_Lymphoma"                                                                                                                           
 [8159] "Stage_IV_Enteropathy-type_T-Cell_Lymphoma"                                                                                                                            
 [8160] "Recurrent_Mycosis_Fungoides"                                                                                                                                          
 [8161] "Refractory_Mycosis_Fungoides"                                                                                                                                         
 [8162] "Recurrent_Mature_T-and_NK-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                
 [8163] "Refractory_Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                          
 [8164] "Stage_I_Mature_T-and_NK-Cell_Lymphoma"                                                                                                                                
 [8165] "Stage_II_Mature_T-and_NK-Cell_Lymphoma"                                                                                                                               
 [8166] "Stage_III_Mature_T-and_NK-Cell_Lymphoma"                                                                                                                              
 [8167] "Stage_IV_Mature_T-and_NK-Cell_Lymphoma"                                                                                                                               
 [8168] "Precursor_T_Lymphoblastic_Leukemia_Lymphoma"                                                                                                                          
 [8169] "Recurrent_Precursor_T_Lymphoblastic_Lymphoma_Leukemia"                                                                                                                
 [8170] "Refractory_Precursor_T_Lymphoblastic_Lymphoma_Leukemia"                                                                                                               
 [8171] "Stage_I_Precursor_T-Lymphoblastic_Lymphoma_Leukemia"                                                                                                                  
 [8172] "Stage_II_Precursor_T-Lymphoblastic_Lymphoma_Leukemia"                                                                                                                 
 [8173] "Stage_III_Precursor_T-Lymphoblastic_Lymphoma_Leukemia"                                                                                                                
 [8174] "Stage_IV_Precursor_T-Lymphoblastic_Lymphoma_Leukemia"                                                                                                                 
 [8175] "Refractory_Non-Hodgkin_s_Lymphoma"                                                                                                                                    
 [8176] "Transformed_Recurrent_Non-Hodgkin_s_Lymphoma"                                                                                                                         
 [8177] "Advanced_Malignant_Pericardial_Mesothelioma"                                                                                                                          
 [8178] "Advanced_Malignant_Peritoneal_Mesothelioma"                                                                                                                           
 [8179] "Recurrent_Malignant_Peritoneal_Mesothelioma"                                                                                                                          
 [8180] "Advanced_Malignant_Pleural_Mesothelioma"                                                                                                                              
 [8181] "Recurrent_Malignant_Pleural_Mesothelioma"                                                                                                                             
 [8182] "Metastatic_Angiosarcoma"                                                                                                                                              
 [8183] "Metastatic_Malignant_Hemangiopericytoma"                                                                                                                              
 [8184] "Primary_Malignant_Hemangiopericytoma"                                                                                                                                 
 [8185] "Non-Cutaneous_Melanoma"                                                                                                                                               
 [8186] "Pineal_Germinoma"                                                                                                                                                     
 [8187] "Bilateral_Retinoblastoma"                                                                                                                                             
 [8188] "Unilateral_Retinoblastoma"                                                                                                                                            
 [8189] "Rhabdoid_Tumour_of_the_Kidney"                                                                                                                                        
 [8190] "Regional_Malignant_Ureter_Neoplasm"                                                                                                                                   
 [8191] "Mucin-Rich_Uterine_Corpus_Endometrioid_Adenocarcinoma"                                                                                                                
 [8192] "Endometrial_Squamous_Cell_Carcinoma"                                                                                                                                  
 [8193] "Stage_I_Fallopian_Tube_Cancer"                                                                                                                                        
 [8194] "Stage_II_Fallopian_Tube_Cancer"                                                                                                                                       
 [8195] "Stage_III_Fallopian_Tube_Cancer"                                                                                                                                      
 [8196] "Stage_I_Ovarian_Dysgerminoma"                                                                                                                                         
 [8197] "Stage_II_Ovarian_Dysgerminoma"                                                                                                                                        
 [8198] "Stage_II_Ovarian_Embryonal_Carcinoma"                                                                                                                                 
 [8199] "Stage_III_Ovarian_Dysgerminoma"                                                                                                                                       
 [8200] "Stage_IV_Ovarian_Dysgerminoma"                                                                                                                                        
 [8201] "Stage_III_Ovarian_Embryonal_Carcinoma"                                                                                                                                
 [8202] "Stage_IV_Ovarian_Embryonal_Carcinoma"                                                                                                                                 
 [8203] "Stage_I_Ovarian_Choriocarcinoma"                                                                                                                                      
 [8204] "Stage_II_Ovarian_Choriocarcinoma"                                                                                                                                     
 [8205] "Stage_III_Ovarian_Choriocarcinoma"                                                                                                                                    
 [8206] "Stage_IV_Ovarian_Choriocarcinoma"                                                                                                                                     
 [8207] "Stage_I_Ovarian_Embryonal_Carcinoma"                                                                                                                                  
 [8208] "Stage_I_Ovarian_Yolk_Sac_Tumor"                                                                                                                                       
 [8209] "Stage_II_Ovarian_Yolk_Sac_Tumor"                                                                                                                                      
 [8210] "Stage_III_Ovarian_Yolk_Sac_Tumor"                                                                                                                                     
 [8211] "Stage_IV_Ovarian_Yolk_Sac_Tumor"                                                                                                                                      
 [8212] "Stage_I_Ovarian_Polyembryoma"                                                                                                                                         
 [8213] "Stage_II_Ovarian_Polyembryoma"                                                                                                                                        
 [8214] "Stage_III_Ovarian_Polyembryoma"                                                                                                                                       
 [8215] "Stage_IV_Ovarian_Polyembryoma"                                                                                                                                        
 [8216] "Stage_I_Ovarian_Teratoma"                                                                                                                                             
 [8217] "Stage_II_Ovarian_Teratoma"                                                                                                                                            
 [8218] "Stage_III_Ovarian_Teratoma"                                                                                                                                           
 [8219] "Stage_IV_Ovarian_Teratoma"                                                                                                                                            
 [8220] "Recurrent_Adenosquamous_Cell_Lung_Carcinoma"                                                                                                                          
 [8221] "Stage_0_Adenosquamous_Lung_Carcinoma"                                                                                                                                 
 [8222] "Stage_I_Adenosquamous_Lung_Carcinoma"                                                                                                                                 
 [8223] "Stage_II_Adenosquamous_Lung_Carcinoma"                                                                                                                                
 [8224] "Stage_III_Adenosquamous_Lung_Carcinoma"                                                                                                                               
 [8225] "Stage_IV_Adenosquamous_Lung_Carcinoma"                                                                                                                                
 [8226] "Recurrent_Large_Cell_Lung_Carcinoma"                                                                                                                                  
 [8227] "Stage_I_Large_Cell_Lung_Carcinoma"                                                                                                                                    
 [8228] "Stage_IV_Large_Cell_Lung_Carcinoma"                                                                                                                                   
 [8229] "Recurrent_Lung_Adenocarcinoma"                                                                                                                                        
 [8230] "Stage_0_Lung_Adenocarcinoma"                                                                                                                                          
 [8231] "Stage_I_Lung_Adenocarcinoma"                                                                                                                                          
 [8232] "Stage_II_Lung_Adenocarcinoma"                                                                                                                                         
 [8233] "Stage_III_Lung_Adenocarcinoma"                                                                                                                                        
 [8234] "Stage_IV_Lung_Adenocarcinoma"                                                                                                                                         
 [8235] "Stage_0_Squamous_Cell_Lung_Carcinoma"                                                                                                                                 
 [8236] "Stage_I_Squamous_Cell_Lung_Carcinoma"                                                                                                                                 
 [8237] "Stage_II_Squamous_Cell_Lung_Carcinoma"                                                                                                                                
 [8238] "Stage_III_Squamous_Cell_Lung_Carcinoma"                                                                                                                               
 [8239] "Stage_IV_Squamous_Cell_Lung_Carcinoma"                                                                                                                                
 [8240] "Stage_I_Pharyngeal_Cancer"                                                                                                                                            
 [8241] "Stage_II_Pharyngeal_Cancer"                                                                                                                                           
 [8242] "Stage_III_Pharyngeal_Cancer"                                                                                                                                          
 [8243] "Stage_IV_Pharyngeal_Cancer"                                                                                                                                           
 [8244] "Stage_I_Lung_Cancer"                                                                                                                                                  
 [8245] "Stage_III_Lung_Cancer"                                                                                                                                                
 [8246] "Stage_IV_Lung_Cancer"                                                                                                                                                 
 [8247] "Peripheral_Neuroectodermal_Tumor_of_Bone"                                                                                                                             
 [8248] "Localized_Chondrosarcoma"                                                                                                                                             
 [8249] "Metastatic_Chondrosarcoma"                                                                                                                                            
 [8250] "Recurrent_Chondrosarcoma"                                                                                                                                             
 [8251] "Stage_I_Acral_Lentiginous_Melanoma"                                                                                                                                   
 [8252] "Stage_II_Acral_Lentiginous_Melanoma"                                                                                                                                  
 [8253] "Stage_III_Acral_Lentiginous_Melanoma"                                                                                                                                 
 [8254] "Stage_IV_Acral_Lentiginous_Melanoma"                                                                                                                                  
 [8255] "Recurrent_Lentigo_Maligna_Melanoma"                                                                                                                                   
 [8256] "Stage_I_Lentigo_Maligna_Melanoma"                                                                                                                                     
 [8257] "Stage_II_Lentigo_Maligna_Melanoma"                                                                                                                                    
 [8258] "Stage_III_Lentigo_Maligna_Melanoma"                                                                                                                                   
 [8259] "Stage_IV_Lentigo_Maligna_Melanoma"                                                                                                                                    
 [8260] "Stage_I_Superficial_Spreading_Melanoma"                                                                                                                               
 [8261] "Stage_II_Superficial_Spreading_Melanoma"                                                                                                                              
 [8262] "Stage_III_Superficial_Spreading_Melanoma"                                                                                                                             
 [8263] "Stage_IV_Superficial_Spreading_Melanoma"                                                                                                                              
 [8264] "Recurrent_Malignant_Fibrous_Histiocytoma"                                                                                                                             
 [8265] "Metastatic_Alveolar_Soft_Part_Sarcoma"                                                                                                                                
 [8266] "Primary_Alveolar_Soft_Part_Sarcoma"                                                                                                                                   
 [8267] "Recurrent_Alveolar_Soft_Part_Sarcoma"                                                                                                                                 
 [8268] "Metastatic_Epithelioid_Sarcoma"                                                                                                                                       
 [8269] "Primary_Epithelioid_Sarcoma"                                                                                                                                          
 [8270] "Metastatic_Extraosseous_Ewing_s_Sarcoma"                                                                                                                              
 [8271] "Non-Metastatic_Extraosseous_Ewing_s_Sarcoma"                                                                                                                          
 [8272] "Recurrent_Extraosseous_Ewing_s_Sarcoma"                                                                                                                               
 [8273] "Metastatic_Extraskeletal_Chondrosarcoma"                                                                                                                              
 [8274] "Extraskeletal_Chondrosarcoma"                                                                                                                                         
 [8275] "Recurrent_Extraskeletal_Chondrosarcoma"                                                                                                                               
 [8276] "Metastatic_Extraskeletal_Osteosarcoma"                                                                                                                                
 [8277] "Non-Metastatic_Extraskeletal_Osteosarcoma"                                                                                                                            
 [8278] "Extraskeletal_Osteosarcoma"                                                                                                                                           
 [8279] "Recurrent_Extraskeletal_Osteosarcoma"                                                                                                                                 
 [8280] "Metastatic_Fibrosarcoma"                                                                                                                                              
 [8281] "Metastatic_Leiomyosarcoma"                                                                                                                                            
 [8282] "Primary_Leiomyosarcoma"                                                                                                                                               
 [8283] "Recurrent_Leiomyosarcoma"                                                                                                                                             
 [8284] "Metastatic_Liposarcoma"                                                                                                                                               
 [8285] "Primary_Liposarcoma"                                                                                                                                                  
 [8286] "Recurrent_Liposarcoma"                                                                                                                                                
 [8287] "Metastatic_Malignant_Peripheral_Nerve_Sheath_Tumor"                                                                                                                   
 [8288] "Recurrent_Malignant_Peripheral_Nerve_Sheath_Tumor"                                                                                                                    
 [8289] "Recurrent_Rhabdomyosarcoma"                                                                                                                                           
 [8290] "Metastatic_Synovial_Sarcoma"                                                                                                                                          
 [8291] "Primary_Synovial_Sarcoma"                                                                                                                                             
 [8292] "Recurrent_Synovial_Sarcoma"                                                                                                                                           
 [8293] "Recurrent_Hodgkin_s_Disease_Lymphocyte_Predominance_Type"                                                                                                             
 [8294] "Refractory_Hodgkin_s_Disease_Lymphocyte_Predominance_Type"                                                                                                            
 [8295] "Stage_III_Hodgkin_s_Disease_Lymphocyte_Predominance_Type"                                                                                                             
 [8296] "Stage_IV_Hodgkin_s_Disease_Lymphocyte_Predominance_Type"                                                                                                              
 [8297] "Recurrent_Mixed_Cellularity_Hodgkin_s_Lymphoma"                                                                                                                       
 [8298] "Refractory_Mixed_Cellularity_Hodgkin_s_Lymphoma"                                                                                                                      
 [8299] "Stage_I_Mixed_Cellularity_Hodgkin_s_Lymphoma"                                                                                                                         
 [8300] "Stage_IV_Mixed_Cellularity_Hodgkin_s_Lymphoma"                                                                                                                        
 [8301] "Refractory_Hodgkin_s_Lymphoma"                                                                                                                                        
 [8302] "Recurrent_Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                                       
 [8303] "Refractory_Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                                      
 [8304] "Stage_I_Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                                         
 [8305] "Stage_IV_Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                                        
 [8306] "Recurrent_B-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                              
 [8307] "Refractory_B-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                             
 [8308] "Stage_II_B-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                               
 [8309] "Stage_III_B-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                              
 [8310] "Stage_IV_B-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                               
 [8311] "Refractory_Small_Lymphocytic_Lymphoma"                                                                                                                                
 [8312] "Refractory_Burkitt_s_Lymphoma"                                                                                                                                        
 [8313] "Stage_I_Burkitt_s_Lymphoma"                                                                                                                                           
 [8314] "Stage_II_Burkitt_s_Lymphoma"                                                                                                                                          
 [8315] "Stage_III_Burkitt_s_Lymphoma"                                                                                                                                         
 [8316] "Diffuse_Large_B-Cell_Lymphoma"                                                                                                                                        
 [8317] "Recurrent_Diffuse_Large_B-Cell_Lymphoma"                                                                                                                              
 [8318] "Refractory_Diffuse_Large_B-Cell_Lymphoma"                                                                                                                             
 [8319] "Stage_I_Diffuse_Large_B-Cell_Lymphoma"                                                                                                                                
 [8320] "Stage_II_Diffuse_Large_B-Cell_Lymphoma"                                                                                                                               
 [8321] "Stage_III_Diffuse_Large_B-Cell_Lymphoma"                                                                                                                              
 [8322] "Stage_IV_Diffuse_Large_B-Cell_Lymphoma"                                                                                                                               
 [8323] "Refractory_Follicular_Lymphoma"                                                                                                                                       
 [8324] "Stage_I_Follicular_Lymphoma"                                                                                                                                          
 [8325] "Stage_II_Follicular_Lymphoma"                                                                                                                                         
 [8326] "Stage_III_Follicular_Lymphoma"                                                                                                                                        
 [8327] "Refractory_Mantle_Cell_Lymphoma"                                                                                                                                      
 [8328] "Nodal_Marginal_Zone_B-Cell_Lymphoma"                                                                                                                                  
 [8329] "Stage_I_Nodal_Marginal_Zone_B-Cell_Lymphoma"                                                                                                                          
 [8330] "Stage_II_Nodal_Marginal_Zone_B-Cell_Lymphoma"                                                                                                                         
 [8331] "Stage_III_Nodal_Marginal_Zone_B-Cell_Lymphoma"                                                                                                                        
 [8332] "Stage_IV_Nodal_Marginal_Zone_B-Cell_Lymphoma"                                                                                                                         
 [8333] "Precursor_B_Lymphoblastic_Lymphoma"                                                                                                                                   
 [8334] "Recurrent_Precursor_B-Lymphoblastic_Lymphoma"                                                                                                                         
 [8335] "Refractory_Precursor_B-Lymphoblastic_Lymphoma"                                                                                                                        
 [8336] "Stage_I_Precursor_B-Lymphoblastic_Lymphoma"                                                                                                                           
 [8337] "Stage_III_Precursor_B-Lymphoblastic_Lymphoma"                                                                                                                         
 [8338] "Stage_IV_Precursor_B-Lymphoblastic_Lymphoma"                                                                                                                          
 [8339] "Recurrent_Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma"                                                                                                              
 [8340] "Refractory_Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma"                                                                                                             
 [8341] "Stage_I_Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma"                                                                                                                
 [8342] "Stage_II_Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma"                                                                                                               
 [8343] "Stage_III_Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma"                                                                                                              
 [8344] "Stage_IV_Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma"                                                                                                               
 [8345] "Extragonadal_Embryonal_Carcinoma"                                                                                                                                     
 [8346] "Malignant_Extragonadal_Germ_Cell_Tumor"                                                                                                                               
 [8347] "Stage_I_Extragonadal_Primary_Mixed_Germ_Cell_Tumor"                                                                                                                   
 [8348] "Stage_III_Extragonadal_Primary_Mixed_Germ_Cell_Tumor"                                                                                                                 
 [8349] "Immature_Extragonadal_Teratoma"                                                                                                                                       
 [8350] "Malignant_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor"                                                                                                              
 [8351] "Stage_I_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor"                                                                                                                
 [8352] "Stage_II_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor"                                                                                                               
 [8353] "Stage_III_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor"                                                                                                              
 [8354] "Stage_IV_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor"                                                                                                               
 [8355] "Stage_II_Extragonadal_Primary_Seminoma"                                                                                                                               
 [8356] "Stage_III_Extragonadal_Primary_Seminoma"                                                                                                                              
 [8357] "Stage_IV_Extragonadal_Primary_Seminoma"                                                                                                                               
 [8358] "Placental_Choriocarcinoma"                                                                                                                                            
 [8359] "Stage_0_Bladder_Adenocarcinoma"                                                                                                                                       
 [8360] "Stage_I_Bladder_Adenocarcinoma"                                                                                                                                       
 [8361] "Stage_II_Bladder_Adenocarcinoma"                                                                                                                                      
 [8362] "Stage_III_Bladder_Adenocarcinoma"                                                                                                                                     
 [8363] "Stage_IV_Bladder_Adenocarcinoma"                                                                                                                                      
 [8364] "Stage_I_Bladder_Cancer_with_Carcinoma_in_situ"                                                                                                                        
 [8365] "Stage_III_Testicular_Choriocarcinoma"                                                                                                                                 
 [8366] "Stage_I_Bladder_Cancer_without_Carcinoma_in_situ"                                                                                                                     
 [8367] "Recurrent_Bladder_Squamous_Cell_Carcinoma"                                                                                                                            
 [8368] "Stage_0_Bladder_Squamous_Cell_Carcinoma"                                                                                                                              
 [8369] "Stage_I_Squamous_Cell_Carcinoma_of_the_Bladder"                                                                                                                       
 [8370] "Stage_III_Bladder_Squamous_Cell_Carcinoma"                                                                                                                            
 [8371] "Stage_IV_Bladder_Squamous_Cell_Carcinoma"                                                                                                                             
 [8372] "Stage_I_Testicular_Choriocarcinoma"                                                                                                                                   
 [8373] "Stage_I_Testicular_Embryonal_Carcinoma"                                                                                                                               
 [8374] "Stage_II_Testicular_Embryonal_Carcinoma"                                                                                                                              
 [8375] "Stage_III_Testicular_Embryonal_Carcinoma"                                                                                                                             
 [8376] "Stage_II_Testicular_Mixed_Germ_Cell_Tumor"                                                                                                                            
 [8377] "Stage_I_Testicular_Mixed_Germ_Cell_Tumor"                                                                                                                             
 [8378] "Stage_III_Testicular_Mixed_Germ_Cell_Tumor"                                                                                                                           
 [8379] "Stage_I_Immature_Testicular_Teratoma"                                                                                                                                 
 [8380] "Stage_II_Immature_Testicular_Teratoma"                                                                                                                                
 [8381] "Stage_III_Immature_Testicular_Teratoma"                                                                                                                               
 [8382] "Stage_I_Testicular_Seminoma"                                                                                                                                          
 [8383] "Stage_II_Testicular_Seminoma"                                                                                                                                         
 [8384] "Stage_III_Testicular_Seminoma"                                                                                                                                        
 [8385] "Stage_I_Testicular_Yolk_Sac_Tumor"                                                                                                                                    
 [8386] "Stage_II_Testicular_Yolk_Sac_Tumor"                                                                                                                                   
 [8387] "Stage_III_Testicular_Yolk_Sac_Tumor"                                                                                                                                  
 [8388] "Acute_Erythroid_Leukemia"                                                                                                                                             
 [8389] "Erythema_Multiforme_Minor"                                                                                                                                            
 [8390] "Metastatic_Melanoma"                                                                                                                                                  
 [8391] "Recurrent_Centroblastic_Lymphoma"                                                                                                                                     
 [8392] "Refractory_Centroblastic_Lymphoma"                                                                                                                                    
 [8393] "Stage_I_Centroblastic_Lymphoma"                                                                                                                                       
 [8394] "Stage_II_Centroblastic_Lymphoma"                                                                                                                                      
 [8395] "Stage_III_Centroblastic_Lymphoma"                                                                                                                                     
 [8396] "Stage_IV_Centroblastic_Lymphoma"                                                                                                                                      
 [8397] "Stage_0_Colorectal_Cancer"                                                                                                                                            
 [8398] "Metastatic_Pancreatic_Adenocarcinoma"                                                                                                                                 
 [8399] "Metastatic_Small_Intestinal_Adenocarcinoma"                                                                                                                           
 [8400] "Papillary_Bile_Duct_Adenocarcinoma"                                                                                                                                   
 [8401] "Precursor_B_Lymphoblastic_Leukemia_Lymphoma"                                                                                                                          
 [8402] "Stage_II_Precursor_B-Lymphoblastic_Lymphoma"                                                                                                                          
 [8403] "Refractory_Cutaneous_T-Cell_Lymphoma"                                                                                                                                 
 [8404] "Stage_II_Bladder_Transitional_Cell_Carcinoma"                                                                                                                         
 [8405] "Stage_III_Bladder_Transitional_Cell_Carcinoma"                                                                                                                        
 [8406] "Stage_IV_Bladder_Transitional_Cell_Carcinoma"                                                                                                                         
 [8407] "Metastatic_Endometrial_Adenocarcinoma"                                                                                                                                
 [8408] "Metastatic_Endometrioid_Adenocarcinoma"                                                                                                                               
 [8409] "Vaginal_Metastatic_Adenocarcinoma"                                                                                                                                    
 [8410] "Metastatic_Prostatic_Adenocarcinoma"                                                                                                                                  
 [8411] "Metastatic_Prostate_Cancer"                                                                                                                                           
 [8412] "Stage_I_Prostate_Adenocarcinoma"                                                                                                                                      
 [8413] "Stage_II_Prostate_Adenocarcinoma"                                                                                                                                     
 [8414] "Stage_III_Prostate_Adenocarcinoma"                                                                                                                                    
 [8415] "Stage_IV_Prostate_Adenocarcinoma"                                                                                                                                     
 [8416] "Stage_IIIA_Adenosquamous_Lung_Carcinoma"                                                                                                                              
 [8417] "Stage_IIIB_Adenosquamous_Lung_Carcinoma"                                                                                                                              
 [8418] "Recurrent_Lung_Cancer"                                                                                                                                                
 [8419] "Stage_II_Lung_Cancer"                                                                                                                                                 
 [8420] "Rete_Testis_Adenocarcinoma"                                                                                                                                           
 [8421] "Stage_IV_Gastric_Cancer_without_Metastasis"                                                                                                                           
 [8422] "Cutaneous_Precancerous_Condition"                                                                                                                                     
 [8423] "Stage_IV_Penile_Cancer"                                                                                                                                               
 [8424] "Familial_Renal_Oncocytoma"                                                                                                                                            
 [8425] "Fundic_Gland_Polyp"                                                                                                                                                   
 [8426] "Gastrointestinal_Intraepithelial_Neoplasia"                                                                                                                           
 [8427] "Stage_IV_Fallopian_Tube_Cancer"                                                                                                                                       
 [8428] "Synovial_Neoplasm"                                                                                                                                                    
 [8429] "Lymphangioma"                                                                                                                                                         
 [8430] "Paraneoplastic_Opsoclonus_Ataxia"                                                                                                                                     
 [8431] "Brain_Iron_Accumulation_Type_I_Syndrome"                                                                                                                              
 [8432] "Grade_2_Follicular_Lymphoma"                                                                                                                                          
 [8433] "Parosteal_Osteosarcoma"                                                                                                                                               
 [8434] "Periosteal_Osteosarcoma"                                                                                                                                              
 [8435] "Embryonal_Rhabdomyosarcoma"                                                                                                                                           
 [8436] "Undifferentiated_Uterine_Sarcoma"                                                                                                                                     
 [8437] "Endometrial_Stromal_Sarcoma"                                                                                                                                          
 [8438] "Malignant_Mixed_Mesodermal_Mullerian_Tumor"                                                                                                                           
 [8439] "Mucinous_Adenofibroma"                                                                                                                                                
 [8440] "Mucinous_Cystadenofibroma"                                                                                                                                            
 [8441] "Adenofibroma"                                                                                                                                                         
 [8442] "Cystadenofibroma"                                                                                                                                                     
 [8443] "Papillary_Adenofibroma"                                                                                                                                               
 [8444] "Clear_Cell_Adenofibroma"                                                                                                                                              
 [8445] "Clear_Cell_Cystadenofibroma"                                                                                                                                          
 [8446] "Oral_Neoplasm"                                                                                                                                                        
 [8447] "Oral_Cavity_Carcinoma"                                                                                                                                                
 [8448] "Malignant_Mastocytosis"                                                                                                                                               
 [8449] "Ureter_Carcinoma"                                                                                                                                                     
 [8450] "Malignant_Lymphoma_Centroblastic_Follicular"                                                                                                                          
 [8451] "Malignant_Lymphoma_Follicular_Large_Noncleaved_Cell_Type"                                                                                                             
 [8452] "Malignant_Lymphoma_Follicular_Large_Cleaved_Cell_Type"                                                                                                                
 [8453] "Blastoma"                                                                                                                                                             
 [8454] "Medullary_Carcinoma"                                                                                                                                                  
 [8455] "Squamous_Cell_Epithelioma"                                                                                                                                            
 [8456] "Adrenal_Cortex_Adenoma"                                                                                                                                               
 [8457] "Benign_Adrenal_Cortex_Neoplasm"                                                                                                                                       
 [8458] "Malignant_Pancreatic_Neoplasm"                                                                                                                                        
 [8459] "Seborrheic_Keratosis"                                                                                                                                                 
 [8460] "Inverted_Follicular_Keratosis"                                                                                                                                        
 [8461] "Subareolar_Duct_Papillomatosis"                                                                                                                                       
 [8462] "Squamous_Papillomatosis"                                                                                                                                              
 [8463] "Mixed_Teratoma_and_Seminoma"                                                                                                                                          
 [8464] "Dermoid_Cyst"                                                                                                                                                         
 [8465] "Adult_Cystic_Teratoma"                                                                                                                                                
 [8466] "Adult_Teratoma"                                                                                                                                                       
 [8467] "Cystic_Teratoma"                                                                                                                                                      
 [8468] "Mature_Teratoma"                                                                                                                                                      
 [8469] "AIDS-Related_Plasmablastic_Lymphoma_of_the_Oral_Cavity"                                                                                                               
 [8470] "AIDS-Related_Primary_Effusion_Lymphoma"                                                                                                                               
 [8471] "Acute_Myeloid_Leukemia_with_inv_16_p13_q22"                                                                                                                           
 [8472] "Acute_Myeloid_Leukemia_with_t_16_16_p13_q22"                                                                                                                          
 [8473] "Acute_Myelomonocytic_Leukemia_with_Abnormal_Eosinophils"                                                                                                              
 [8474] "Childhood_Astrocytic_Tumor"                                                                                                                                           
 [8475] "Sarcoma_by_FNCLCC_Grade"                                                                                                                                              
 [8476] "Sarcoma_Differentiation_Score_1"                                                                                                                                      
 [8477] "Well_Differentiated_Fibrosarcoma"                                                                                                                                     
 [8478] "Low-Grade_Malignant_Peripheral_Nerve_Sheath_Tumor"                                                                                                                    
 [8479] "Well_Differentiated_Chondrosarcoma"                                                                                                                                   
 [8480] "Sarcoma_Differentiation_Score_2"                                                                                                                                      
 [8481] "Sarcoma_Differentiation_Score_3"                                                                                                                                      
 [8482] "High-Grade_Malignant_Peripheral_Nerve_Sheath_Tumor"                                                                                                                   
 [8483] "Poorly_Differentiated_Angiosarcoma"                                                                                                                                   
 [8484] "Stage_I_Adult_Hodgkin_s_Lymphoma"                                                                                                                                     
 [8485] "Stage_II_Adult_Hodgkin_s_Lymphoma"                                                                                                                                    
 [8486] "Stage_III_Adult_Hodgkin_s_Lymphoma"                                                                                                                                   
 [8487] "Stage_IV_Adult_Hodgkin_s_Lymphoma"                                                                                                                                    
 [8488] "Stage_IV_Gastric_Cancer"                                                                                                                                              
 [8489] "Stage_I_Anal_Canal_Cancer"                                                                                                                                            
 [8490] "Occult_Non-Small_Cell_Lung_Carcinoma"                                                                                                                                 
 [8491] "Cervical_Carcinoma"                                                                                                                                                   
 [8492] "Adult_Angiosarcoma"                                                                                                                                                   
 [8493] "Childhood_Infratentorial_Ependymoma"                                                                                                                                  
 [8494] "Childhood_Brain_Stem_Glioma"                                                                                                                                          
 [8495] "Childhood_Supratentorial_Ependymoma"                                                                                                                                  
 [8496] "Metastatic_Parathyroid_Carcinoma"                                                                                                                                     
 [8497] "Recurrent_Childhood_Central_Nervous_System_Neoplasm"                                                                                                                  
 [8498] "Recurrent_Childhood_Hepatocellular_Carcinoma"                                                                                                                         
 [8499] "Childhood_Intraocular_Retinoblastoma"                                                                                                                                 
 [8500] "Childhood_Extraocular_Retinoblastoma"                                                                                                                                 
 [8501] "Extensive_Stage_Small_Cell_Lung_Carcinoma"                                                                                                                            
 [8502] "Recurrent_Small_Cell_Lung_Carcinoma"                                                                                                                                  
 [8503] "Stage_II_Vulvar_Cancer"                                                                                                                                               
 [8504] "Stage_III_Vulvar_Cancer"                                                                                                                                              
 [8505] "Stage_IV_Vulvar_Cancer"                                                                                                                                               
 [8506] "Recurrent_Vulvar_Cancer"                                                                                                                                              
 [8507] "Bartholin_s_Gland_Carcinoma"                                                                                                                                          
 [8508] "Stage_I_Childhood_Lymphoblastic_Lymphoma"                                                                                                                             
 [8509] "Stage_II_Childhood_Lymphoblastic_Lymphoma"                                                                                                                            
 [8510] "Stage_III_Childhood_Lymphoblastic_Lymphoma"                                                                                                                           
 [8511] "Stage_IV_Childhood_Lymphoblastic_Lymphoma"                                                                                                                            
 [8512] "Recurrent_Childhood_Lymphoblastic_Lymphoma"                                                                                                                           
 [8513] "Penile_Carcinoma"                                                                                                                                                     
 [8514] "Adult_Burkitt_s_Lymphoma"                                                                                                                                             
 [8515] "Malignant_Testicular_Germ_Cell_Tumor"                                                                                                                                 
 [8516] "Localized_Resectable_Adult_Primary_Hepatoma"                                                                                                                          
 [8517] "Localized_Unresectable_Adult_Primary_Hepatoma"                                                                                                                        
 [8518] "Recurrent_Adult_Primary_Hepatoma"                                                                                                                                     
 [8519] "Recurrent_Childhood_Acute_Myeloid_Leukemia"                                                                                                                           
 [8520] "Pancreatic_G-Cell_Gastrin_Producing_Neoplasm"                                                                                                                         
 [8521] "Relapsed_Chronic_Myelogenous_Leukemia"                                                                                                                                
 [8522] "Stage_0_Endometrial_Cancer"                                                                                                                                           
 [8523] "Recurrent_Endometrial_Carcinoma"                                                                                                                                      
 [8524] "Stage_II_Testicular_Cancer"                                                                                                                                           
 [8525] "Stage_III_Testicular_Cancer"                                                                                                                                          
 [8526] "Stage_IV_Prostate_Cancer"                                                                                                                                             
 [8527] "Childhood_Diffuse_Large_Cell_Lymphoma"                                                                                                                                
 [8528] "Refractory_Testicular_Cancer"                                                                                                                                         
 [8529] "Childhood_Immunoblastic_Lymphoma"                                                                                                                                     
 [8530] "Noninvasive_Malignant_Thymoma"                                                                                                                                        
 [8531] "Stage_I_Thyroid_Papillary_Carcinoma"                                                                                                                                  
 [8532] "Stage_II_Thyroid_Papillary_Carcinoma"                                                                                                                                 
 [8533] "Stage_IV_Thyroid_Papillary_Carcinoma"                                                                                                                                 
 [8534] "Stage_I_Thyroid_Follicular_Carcinoma"                                                                                                                                 
 [8535] "Stage_II_Thyroid_Follicular_Carcinoma"                                                                                                                                
 [8536] "Stage_IV_Thyroid_Follicular_Carcinoma"                                                                                                                                
 [8537] "Kaposi_s_Sarcoma"                                                                                                                                                     
 [8538] "Iris_Melanoma"                                                                                                                                                        
 [8539] "Small_Size_Posterior_Uveal_Melanoma"                                                                                                                                  
 [8540] "Medium_Large_Size_Posterior_Uveal_Melanoma"                                                                                                                           
 [8541] "Adult_Brain_Stem_Glioma"                                                                                                                                              
 [8542] "Adult_Ependymoma"                                                                                                                                                     
 [8543] "Adult_Meningioma"                                                                                                                                                     
 [8544] "Adult_Glioblastoma"                                                                                                                                                   
 [8545] "Childhood_Burkitt_s_Lymphoma"                                                                                                                                         
 [8546] "Stage_IV_Melanoma_of_the_Skin"                                                                                                                                        
 [8547] "Recurrent_Melanoma_of_the_Skin"                                                                                                                                       
 [8548] "Low-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                               
 [8549] "Stage_0_Nasopharyngeal_Carcinoma"                                                                                                                                     
 [8550] "Stage_0_Laryngeal_Cancer"                                                                                                                                             
 [8551] "Stage_0_Hypopharyngeal_Cancer"                                                                                                                                        
 [8552] "Stage_IIIA_Non-Small_Cell_Lung_Cancer"                                                                                                                                
 [8553] "Stage_IIIB_Non-Small_Cell_Lung_Cancer"                                                                                                                                
 [8554] "Stage_0_Non-Small_Cell_Lung_Cancer"                                                                                                                                   
 [8555] "Oropharyngeal_Carcinoma"                                                                                                                                              
 [8556] "Urethral_Carcinoma"                                                                                                                                                   
 [8557] "Childhood_Solid_Neoplasm"                                                                                                                                             
 [8558] "Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                      
 [8559] "High-Grade_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                              
 [8560] "Blast_Phase_Chronic_Myelogenous_Leukemia"                                                                                                                             
 [8561] "Meningeal_Chronic_Myelogenous_Leukemia"                                                                                                                               
 [8562] "Classic_Kaposi_s_Sarcoma"                                                                                                                                             
 [8563] "Kaposi_s_Sarcoma_Related_to_Immunosuppressive_Treatment"                                                                                                              
 [8564] "Adult_Acute_Leukemia_in_Remission"                                                                                                                                    
 [8565] "Childhood_Acute_Myeloid_Leukemia_in_Remission"                                                                                                                        
 [8566] "Childhood_Acute_Leukemia_in_Remission"                                                                                                                                
 [8567] "Recurrent_Metastatic_Squamous_Cell_Carcinoma_to_the_Neck_with_Occult_Primary"                                                                                         
 [8568] "Sarcoma_of_the_Soft_Tissue_and_Bone"                                                                                                                                  
 [8569] "Medullary_Breast_Carcinoma"                                                                                                                                           
 [8570] "Pancreatic_Ductal_Adenocarcinoma"                                                                                                                                     
 [8571] "Stage_III_Thyroid_Follicular_Carcinoma"                                                                                                                               
 [8572] "Stage_III_Thyroid_Papillary_Carcinoma"                                                                                                                                
 [8573] "Ovarian_Mixed_Epithelial_Carcinoma"                                                                                                                                   
 [8574] "Childhood_Lymphoblastic_Lymphoma"                                                                                                                                     
 [8575] "Adult_Lymphocyte_Depleted_Hodgkin_s_Lymphoma"                                                                                                                         
 [8576] "Adult_Nodular_Sclerosis_Hodgkin_s_Lymphoma"                                                                                                                           
 [8577] "Adult_Mixed_Cellularity_Hodgkin_s_Lymphoma"                                                                                                                           
 [8578] "Philadelphia_Chromosome_Positive_Chronic_Myelogenous_Leukemia"                                                                                                        
 [8579] "Philadelphia_Chromosome_Negative_Chronic_Myelogenous_Leukemia"                                                                                                        
 [8580] "Adult_Rhabdomyosarcoma"                                                                                                                                               
 [8581] "Mucinous_Breast_Carcinoma"                                                                                                                                            
 [8582] "Invasive_Ductal_Breast_Carcinoma_with_Predominant_Intraductal_Component"                                                                                              
 [8583] "Adenosquamous_Lung_Carcinoma"                                                                                                                                         
 [8584] "Papillary_Breast_Carcinoma"                                                                                                                                           
 [8585] "Tubular_Breast_Carcinoma"                                                                                                                                             
 [8586] "Invasive_Lobular_Breast_Carcinoma_with_Predominant_In_Situ_Component"                                                                                                 
 [8587] "Combined_Type_Small_Cell_Lung_Carcinoma"                                                                                                                              
 [8588] "Childhood_Precursor_B_Lymphoblastic_Leukemia"                                                                                                                         
 [8589] "Non-T_Non-B_cALLa_Positive_Childhood_Acute_Lymphoblastic_Leukemia"                                                                                                    
 [8590] "Adult_Precursor_T_Lymphoblastic_Leukemia"                                                                                                                             
 [8591] "Adult_Precursor_B_Lymphoblastic_Leukemia"                                                                                                                             
 [8592] "Non-T_Non-B_cALLa_Positive_Adult_Acute_Lymphoblastic_Leukemia"                                                                                                        
 [8593] "Osteosarcoma"                                                                                                                                                         
 [8594] "Epithelial_Predominant_Wilms_Tumor"                                                                                                                                   
 [8595] "Blastema_Predominant_Wilms_Tumor"                                                                                                                                     
 [8596] "Stromal_Predominant_Wilms_Tumor"                                                                                                                                      
 [8597] "Mixed_Cell_Type_Wilms_Tumor"                                                                                                                                          
 [8598] "Botryoid-Type_Embryonal_Rhabdomyosarcoma"                                                                                                                             
 [8599] "Lentigo_Maligna_Melanoma"                                                                                                                                             
 [8600] "Superficial_Spreading_Melanoma_of_the_Skin"                                                                                                                           
 [8601] "Adult_Acute_Erythroid_Leukemia"                                                                                                                                       
 [8602] "Adult_Acute_Myeloid_Leukemia"                                                                                                                                         
 [8603] "Adult_Acute_Promyelocytic_Leukemia"                                                                                                                                   
 [8604] "Adult_Acute_Poorly_Differentiated_Monoblastic_Leukemia"                                                                                                               
 [8605] "Gastric_Intestinal_Type_Adenocarcinoma"                                                                                                                               
 [8606] "Childhood_Acute_Myeloid_Leukemia_without_Maturation"                                                                                                                  
 [8607] "Diffuse_Gastric_Adenocarcinoma"                                                                                                                                       
 [8608] "Childhood_Acute_Myeloid_Leukemia"                                                                                                                                     
 [8609] "Anal_Squamous_Cell_Carcinoma"                                                                                                                                         
 [8610] "Childhood_Acute_Monoblastic_Leukemia_without_Differentiation"                                                                                                         
 [8611] "Childhood_Acute_Differentiated_Monocytic_Leukemia"                                                                                                                    
 [8612] "Childhood_Acute_Erythroid_Leukemia"                                                                                                                                   
 [8613] "Childhood_Acute_Eosinophilic_Leukemia"                                                                                                                                
 [8614] "Gallbladder_Adenocarcinoma"                                                                                                                                           
 [8615] "Undifferentiated_Gallbladder_Carcinoma"                                                                                                                               
 [8616] "Rectal_Signet_Ring_Cell_Adenocarcinoma"                                                                                                                               
 [8617] "Gallbladder_Adenocarcinoma_with_Squamous_Metaplasia"                                                                                                                  
 [8618] "Gallbladder_Squamous_Cell_Carcinoma"                                                                                                                                  
 [8619] "Mixed_Embryonal_Carcinoma_and_Yolk_Sac_Neoplasm_with_Seminoma_of_the_Testis"                                                                                          
 [8620] "Testicular_Mixed_Choriocarcinoma_and_Seminoma"                                                                                                                        
 [8621] "Childhood_Angiosarcoma"                                                                                                                                               
 [8622] "Bowel_Obstruction"                                                                                                                                                    
 [8623] "Non-Metastatic_Gestational_Trophoblastic_Tumor"                                                                                                                       
 [8624] "Good_Prognosis_Metastatic_Gestational_Trophoblastic_Tumor"                                                                                                            
 [8625] "Poor_Prognosis_Metastatic_Gestational_Trophoblastic_Tumor"                                                                                                            
 [8626] "Stage_IV_Uterine_Sarcoma"                                                                                                                                             
 [8627] "Uterine_Corpus_Malignant_Mixed_Mesodermal_Mullerian_Tumor"                                                                                                            
 [8628] "Recurrent_Carcinoma_of_Unknown_Primary"                                                                                                                               
 [8629] "Deep_Fibromatosis_Desmoid_Tumor"                                                                                                                                      
 [8630] "Malignant_Adult_Intracranial_Hemangiopericytoma"                                                                                                                      
 [8631] "Intraocular_Lymphoma"                                                                                                                                                 
 [8632] "Stage_I_Childhood_Burkitt_s_Lymphoma"                                                                                                                                 
 [8633] "Stage_II_Childhood_Burkitt_s_Lymphoma"                                                                                                                                
 [8634] "Stage_III_Childhood_Burkitt_s_Lymphoma"                                                                                                                               
 [8635] "Stage_IV_Childhood_Burkitt_s_Lymphoma"                                                                                                                                
 [8636] "Recurrent_Childhood_Burkitt_s_Lymphoma"                                                                                                                               
 [8637] "Recurrent_Childhood_Brain_Stem_Glioma"                                                                                                                                
 [8638] "Recurrent_Childhood_Cerebral_Astrocytoma"                                                                                                                             
 [8639] "Ovarian_Malignant_Mixed_Mesodermal_Mullerian_Tumor"                                                                                                                   
 [8640] "Stage_II_Contiguous_Adult_Burkitt_s_Lymphoma"                                                                                                                         
 [8641] "Stage_II_Grade_1_Non-Contiguous_Follicular_Lymphoma"                                                                                                                  
 [8642] "Stage_II_Grade_2_Non-Contiguous_Follicular_Lymphoma"                                                                                                                  
 [8643] "Stage_II_Grade_3_Non-Contiguous_Follicular_Lymphoma"                                                                                                                  
 [8644] "Stage_II_Non-Contiguous_Adult_Diffuse_Small_Cleaved_Cell_Lymphoma"                                                                                                    
 [8645] "Stage_II_Non-Contiguous_Mantle_Cell_Lymphoma"                                                                                                                         
 [8646] "Stage_II_Non-Contiguous_Adult_Diffuse_Mixed_Cell_Lymphoma"                                                                                                            
 [8647] "Stage_II_Non-Contiguous_Adult_Burkitt_s_Lymphoma"                                                                                                                     
 [8648] "Angioimmunoblastic_Lymphadenopathy_with_Dysproteinemia"                                                                                                               
 [8649] "Stage_II_Mantle_Cell_Lymphoma"                                                                                                                                        
 [8650] "Breakthrough_Pain"                                                                                                                                                    
 [8651] "Stage_I_Cervical_Cancer"                                                                                                                                              
 [8652] "Stage_III_Cervical_Cancer"                                                                                                                                            
 [8653] "Stage_IV_Cervical_Cancer"                                                                                                                                             
 [8654] "Stage_I_Endometrial_Cancer"                                                                                                                                           
 [8655] "Stage_II_Endometrial_Cancer"                                                                                                                                          
 [8656] "Stage_III_Endometrial_Cancer"                                                                                                                                         
 [8657] "Stage_I_Esophageal_Cancer"                                                                                                                                            
 [8658] "Stage_II_Esophageal_Cancer"                                                                                                                                           
 [8659] "Stage_III_Esophageal_Cancer"                                                                                                                                          
 [8660] "Stage_IV_Esophageal_Cancer"                                                                                                                                           
 [8661] "Stage_I_Adrenal_Cortex_Carcinoma"                                                                                                                                     
 [8662] "Stage_II_Adrenal_Cortex_Carcinoma"                                                                                                                                    
 [8663] "Stage_III_Adrenal_Cortex_Carcinoma"                                                                                                                                   
 [8664] "Stage_IV_Adrenal_Cortex_Carcinoma"                                                                                                                                    
 [8665] "Stage_IV_Oropharyngeal_Carcinoma"                                                                                                                                     
 [8666] "Cancer_Patient_and_Depression_and_Suicide"                                                                                                                            
 [8667] "Stage_III_Renal_Cell_Cancer"                                                                                                                                          
 [8668] "Recurrent_Childhood_Malignant_Germ_Cell_Neoplasm"                                                                                                                     
 [8669] "Hereditary_Renal_Papillary_Carcinoma"                                                                                                                                 
 [8670] "Esophagitis"                                                                                                                                                          
 [8671] "Oral_Complications_of_Chemotherapy_and_Head_and_Neck_Radiation"                                                                                                       
 [8672] "Non-Hematologic_Malignancy"                                                                                                                                           
 [8673] "Hypogonadotropism"                                                                                                                                                    
 [8674] "Terminal_Disease"                                                                                                                                                     
 [8675] "Systemic_Disease"                                                                                                                                                     
 [8676] "Myelosuppression"                                                                                                                                                     
 [8677] "Neuroendocrine_Carcinoma_of_the_Skin"                                                                                                                                 
 [8678] "Weight_Change"                                                                                                                                                        
 [8679] "Juvenile_Myelomonocytic_Leukemia"                                                                                                                                     
 [8680] "Childhood_Spinal_Cord_Neoplasm"                                                                                                                                       
 [8681] "Systemic_Mastocytosis"                                                                                                                                                
 [8682] "Paroxysmal_Hypertension"                                                                                                                                              
 [8683] "Recurrent_Gastric_Cancer"                                                                                                                                             
 [8684] "Recurrent_Rectal_Cancer"                                                                                                                                              
 [8685] "Localized_Malignant_Mesothelioma"                                                                                                                                     
 [8686] "Recurrent_Nasopharyngeal_Carcinoma"                                                                                                                                   
 [8687] "Recurrent_Hypopharyngeal_Carcinoma"                                                                                                                                   
 [8688] "Malignant_Colon_Neoplasm"                                                                                                                                             
 [8689] "Hypertension_Associated_Disorders_of_Pregnancy"                                                                                                                       
 [8690] "Aggressive_Non-Hodgkin_s_Lymphoma"                                                                                                                                    
 [8691] "Invasive_Breast_Carcinoma"                                                                                                                                            
 [8692] "Stage_IIIB_Inflammatory_Breast_Carcinoma"                                                                                                                             
 [8693] "Bladder_Granuloma"                                                                                                                                                    
 [8694] "Silicon_Granuloma"                                                                                                                                                    
 [8695] "Recurrent_AIDS-Related_Anal_Canal_Cancer"                                                                                                                             
 [8696] "Recurrent_Anaplastic_Large_Cell_Lymphoma"                                                                                                                             
 [8697] "Recurrent_Non-Hodgkin_s_Lymphoma"                                                                                                                                     
 [8698] "Stage_I_Aggressive_Adult_Non-Hodgkin_s_Lymphoma"                                                                                                                      
 [8699] "Recurrent_Malignant_Pericardial_Mesothelioma"                                                                                                                         
 [8700] "Recurrent_Malignant_Hemangiopericytoma"                                                                                                                               
 [8701] "Recurrent_Ureter_Cancer"                                                                                                                                              
 [8702] "Stage_III_Large_Cell_Lung_Carcinoma"                                                                                                                                  
 [8703] "Aggravated_Granuloma_Annulare"                                                                                                                                        
 [8704] "Actinomycotic_Granuloma"                                                                                                                                              
 [8705] "Recurrent_Malignant_Oral_Neoplasm"                                                                                                                                    
 [8706] "Recurrent_Malignant_Duodenal_Neoplasm"                                                                                                                                
 [8707] "Recurrent_Hepatocellular_Carcinoma"                                                                                                                                   
 [8708] "Mycosis_Fungoides_and_Sezary_Syndrome"                                                                                                                                
 [8709] "Recurrent_Malignant_Bladder_Neoplasm"                                                                                                                                 
 [8710] "Stage_0a_Bladder_Cancer"                                                                                                                                              
 [8711] "Recurrent_Malignant_Nasopharyngeal_Neoplasm"                                                                                                                          
 [8712] "Recurrent_Malignant_Endocervical_Neoplasm"                                                                                                                            
 [8713] "Advanced_Malignant_Neoplasm"                                                                                                                                          
 [8714] "Postoperative_Hypertension"                                                                                                                                           
 [8715] "Salivary_Gland_Carcinoma"                                                                                                                                             
 [8716] "Cardiac_Granuloma"                                                                                                                                                    
 [8717] "Primary_Angiosarcoma"                                                                                                                                                 
 [8718] "Metastatic_Carcinoma_to_Adrenal_Medulla"                                                                                                                              
 [8719] "Testicular_Leukemia"                                                                                                                                                  
 [8720] "AIDS-Related_Anal_Carcinoma"                                                                                                                                          
 [8721] "AIDS-Related_Hodgkin_s_Lymphoma"                                                                                                                                      
 [8722] "Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma"                                                                                                                        
 [8723] "Follicular_Dendritic_Cell_Sarcoma"                                                                                                                                    
 [8724] "Interdigitating_Dendritic_Cell_Sarcoma"                                                                                                                               
 [8725] "Lymphocyte_Depleted_Hodgkin_s_Lymphoma"                                                                                                                               
 [8726] "Systemic_Mastocytosis_with_Associated_Clonal_Hematological_non-Mast-Cell_Lineage_Disease"                                                                             
 [8727] "Aggressive_Systemic_Mastocytosis"                                                                                                                                     
 [8728] "Indolent_Systemic_Mastocytosis"                                                                                                                                       
 [8729] "Acute_Myeloid_Leukemia_with_Abnormal_Marrow_Eosinophils"                                                                                                              
 [8730] "Acute_Myeloid_Leukemia_with_t_8_21_q22_q22_AML1_CBFa_ETO"                                                                                                             
 [8731] "De_novo_Acute_Myeloid_Leukemia_with_Multilineage_Dysplasia"                                                                                                           
 [8732] "Myeloid_Neoplasm"                                                                                                                                                     
 [8733] "Anal_Carcinoma"                                                                                                                                                       
 [8734] "Solid_Neoplasm"                                                                                                                                                       
 [8735] "Central_Nervous_System_Neoplasm"                                                                                                                                      
 [8736] "Histiocytic_and_Dendritic_Cell_Neoplasms"                                                                                                                             
 [8737] "Mast_Cell_Neoplasm"                                                                                                                                                   
 [8738] "Adenocarcinoma_of_the_Gastroesophageal_Junction"                                                                                                                      
 [8739] "Malignant_Urinary_Tract_Neoplasm"                                                                                                                                     
 [8740] "Stem_Cell_Leukemia"                                                                                                                                                   
 [8741] "Acute_Undifferentiated_Leukemia"                                                                                                                                      
 [8742] "Acute_Leukemia"                                                                                                                                                       
 [8743] "Central_Nervous_System_Lymphoma"                                                                                                                                      
 [8744] "Primary_Central_Nervous_System_Lymphoma"                                                                                                                              
 [8745] "Mastocytoma"                                                                                                                                                          
 [8746] "Mastocytosis"                                                                                                                                                         
 [8747] "Malignant_Neoplasm"                                                                                                                                                   
 [8748] "Soft_Tissue_Sarcoma"                                                                                                                                                  
 [8749] "Lymphadenopathy_with_Polyclonal_Hypergammaglobulinemia"                                                                                                               
 [8750] "Lymphoproliferative_Disorder"                                                                                                                                         
 [8751] "Seminoma"                                                                                                                                                             
 [8752] "Extragonadal_Primary_Seminoma"                                                                                                                                        
 [8753] "Malignant_Cervical_Neoplasm"                                                                                                                                          
 [8754] "Bone_Sarcoma"                                                                                                                                                         
 [8755] "Testicular_Non-Seminomatous_Germ_Cell_Tumor"                                                                                                                          
 [8756] "Malignant_Oral_Cavity_Neoplasm"                                                                                                                                       
 [8757] "Lip_and_Oral_Cavity_Carcinoma"                                                                                                                                        
 [8758] "Malignant_Oral_Neoplasm"                                                                                                                                              
 [8759] "Malignant_Gingival_Neoplasm"                                                                                                                                          
 [8760] "Malignant_Floor_of_the_Mouth_Neoplasm"                                                                                                                                
 [8761] "Floor_of_the_Mouth_Carcinoma"                                                                                                                                         
 [8762] "Malignant_Buccal_Mucosa_Neoplasm"                                                                                                                                     
 [8763] "Malignant_Nasopharyngeal_Neoplasm"                                                                                                                                    
 [8764] "Malignant_Parathyroid_Neoplasm"                                                                                                                                       
 [8765] "Malignant_Postcricoid_Neoplasm"                                                                                                                                       
 [8766] "Adrenal_Gland_Carcinoma"                                                                                                                                              
 [8767] "Adrenal_Cortex_Carcinoma"                                                                                                                                             
 [8768] "Adrenal_Cortex_Adenocarcinoma"                                                                                                                                        
 [8769] "Malignant_Adrenal_Cortex_Neoplasm"                                                                                                                                    
 [8770] "Malignant_Duodenal_Neoplasm"                                                                                                                                          
 [8771] "Malignant_Cecum_Neoplasm"                                                                                                                                             
 [8772] "Appendix_Carcinoma"                                                                                                                                                   
 [8773] "Malignant_Gastric_Neoplasm"                                                                                                                                           
 [8774] "Maxillary_Sinus_Carcinoma"                                                                                                                                            
 [8775] "Malignant_Appendix_Neoplasm"                                                                                                                                          
 [8776] "Malignant_Bladder_Neoplasm"                                                                                                                                           
 [8777] "Malignant_Breast_Neoplasm"                                                                                                                                            
 [8778] "Nasal_Cavity_Carcinoma"                                                                                                                                               
 [8779] "Malignant_Ear_Neoplasm"                                                                                                                                               
 [8780] "Malignant_Adrenal_Gland_Neoplasm"                                                                                                                                     
 [8781] "Refractory_Peripheral_T-Cell_Lymphoma_Unspecified"                                                                                                                    
 [8782] "Peripheral_Primitive_Neuroectodermal_Tumor"                                                                                                                           
 [8783] "Spindle_Cell_Intraocular_Melanoma"                                                                                                                                    
 [8784] "Bone_Neoplasm"                                                                                                                                                        
 [8785] "Pineoblastoma"                                                                                                                                                        
 [8786] "Malignant_Tongue_Neoplasm"                                                                                                                                            
 [8787] "Malignant_Tracheal_Neoplasm"                                                                                                                                          
 [8788] "Tracheal_Carcinoma"                                                                                                                                                   
 [8789] "Mast_Cell_Sarcoma"                                                                                                                                                    
 [8790] "Plasmacytoma"                                                                                                                                                         
 [8791] "Malignant_Peritoneal_Mesothelioma"                                                                                                                                    
 [8792] "Pleural_Mesothelioma"                                                                                                                                                 
 [8793] "Recurrent_Duodenal_Cancer"                                                                                                                                            
 [8794] "Recurrent_Malignant_Hypopharyngeal_Neoplasm"                                                                                                                          
 [8795] "Recurrent_Malignant_Gastric_Neoplasm"                                                                                                                                 
 [8796] "Stage_IVB_Vaginal_Cancer"                                                                                                                                             
 [8797] "Regional_Ureter_Cancer"                                                                                                                                               
 [8798] "Hodgkin_s_Lymphoma"                                                                                                                                                   
 [8799] "Stage_I_Colon_Cancer"                                                                                                                                                 
 [8800] "Pigmented_Basal_Cell_Carcinoma"                                                                                                                                       
 [8801] "Precursor_Lymphoblastic_Lymphoma"                                                                                                                                     
 [8802] "Adult_Lymphoblastic_Lymphoma"                                                                                                                                         
 [8803] "Clitoral_Carcinoma"                                                                                                                                                   
 [8804] "Labia_Majora_Carcinoma"                                                                                                                                               
 [8805] "Labia_Minora_Carcinoma"                                                                                                                                               
 [8806] "Stage_IIA_Bladder_Cancer"                                                                                                                                             
 [8807] "Stage_IIB_Bladder_Cancer"                                                                                                                                             
 [8808] "Stage_IVA_Bladder_Cancer"                                                                                                                                             
 [8809] "Stage_IVB_Bladder_Cancer"                                                                                                                                             
 [8810] "Recurrent_Testicular_Cancer"                                                                                                                                          
 [8811] "Adult_Brain_Stem_Gliosarcoma"                                                                                                                                         
 [8812] "Adult_Brain_Stem_Mixed_Glioma"                                                                                                                                        
 [8813] "Adult_Brain_Ependymoma"                                                                                                                                               
 [8814] "Adult_Brain_Medulloblastoma"                                                                                                                                          
 [8815] "Adult_Brain_Meningioma"                                                                                                                                               
 [8816] "Adult_Brain_Glioblastoma"                                                                                                                                             
 [8817] "Adult_Brain_Oligodendroglioma"                                                                                                                                        
 [8818] "Brain_Oligodendroglioma"                                                                                                                                              
 [8819] "Childhood_Myeloid_Leukemia_in_Remission"                                                                                                                              
 [8820] "Adenocarcinoma_and_Small_Cell_Lung_Carcinoma"                                                                                                                         
 [8821] "Adult_Acute_Myeloid_Leukemia_without_Maturation"                                                                                                                      
 [8822] "Childhood_Acute_Myeloid_Leukemia_with_Maturation"                                                                                                                     
 [8823] "Rectal_Carcinoma"                                                                                                                                                     
 [8824] "Rectal_Adenocarcinoma"                                                                                                                                                
 [8825] "Renal_Carcinoma"                                                                                                                                                      
 [8826] "Renal_Cell_Carcinoma"                                                                                                                                                 
 [8827] "Sarcoma_by_NCI_Grade"                                                                                                                                                 
 [8828] "Sarcoma_NCI_Grade_1"                                                                                                                                                  
 [8829] "Well_Differentiated_Leiomyosarcoma"                                                                                                                                   
 [8830] "Leiomyosarcoma_NCI_Grade_3"                                                                                                                                           
 [8831] "Leiomyosarcoma_NCI_Grade_2"                                                                                                                                           
 [8832] "Well_Differentiated_Malignant_Hemangiopericytoma"                                                                                                                     
 [8833] "Malignant_Hemangiopericytoma_NCI_Grade_2"                                                                                                                             
 [8834] "Malignant_Hemangiopericytoma_NCI_Grade_3"                                                                                                                             
 [8835] "Chondrosarcoma_NCI_Grade_3"                                                                                                                                           
 [8836] "Chondrosarcoma_NCI_Grade_2"                                                                                                                                           
 [8837] "Chondrosarcoma_NCI_Grade_1"                                                                                                                                           
 [8838] "Myxoid_Chondrosarcoma_NCI_Grade_1"                                                                                                                                    
 [8839] "Myxoid_Chondrosarcoma_NCI_Grade_2"                                                                                                                                    
 [8840] "Sarcoma_NCI_Grade_2"                                                                                                                                                  
 [8841] "Round_Cell_Liposarcoma_NCI_Grade_2"                                                                                                                                   
 [8842] "Round_Cell_Liposarcoma_NCI_Grade_3"                                                                                                                                   
 [8843] "Fibrosarcoma_NCI_Grade_2"                                                                                                                                             
 [8844] "Poorly_Differentiated_Fibrosarcoma"                                                                                                                                   
 [8845] "Storiform-Pleomorphic_Malignant_Fibrous_Histiocytoma_NCI_Grade_2"                                                                                                     
 [8846] "Storiform-Pleomorphic_Malignant_Fibrous_Histiocytoma_NCI_Grade_3"                                                                                                     
 [8847] "Inflammatory_Malignant_Fibrous_Histiocytoma_NCI_Grade_2"                                                                                                              
 [8848] "Inflammatory_Malignant_Fibrous_Histiocytoma_NCI_Grade_3"                                                                                                              
 [8849] "Epithelioid_Sarcoma_NCI_Grade_2"                                                                                                                                      
 [8850] "Epithelioid_Sarcoma_NCI_Grade_3"                                                                                                                                      
 [8851] "Angiosarcoma_NCI_Grade_2"                                                                                                                                             
 [8852] "Angiosarcoma_NCI_Grade_3"                                                                                                                                             
 [8853] "Kaposi_s_Sarcoma_NCI_Grade_2"                                                                                                                                         
 [8854] "Kaposi_s_Sarcoma_NCI_Grade_3"                                                                                                                                         
 [8855] "Sarcoma_NCI_Grade_3"                                                                                                                                                  
 [8856] "Sarcoma_by_AJCC_Grade"                                                                                                                                                
 [8857] "Low-Grade_Sarcoma"                                                                                                                                                    
 [8858] "High-Grade_Sarcoma"                                                                                                                                                   
 [8859] "AJCC_Grade_1_Sarcoma"                                                                                                                                                 
 [8860] "AJCC_Grade_2_Sarcoma"                                                                                                                                                 
 [8861] "AJCC_Grade_3_Sarcoma"                                                                                                                                                 
 [8862] "AJCC_Grade_4_Sarcoma"                                                                                                                                                 
 [8863] "Mixed_Small_Cell_and_Squamous_Cell_Lung_Carcinoma"                                                                                                                    
 [8864] "Combined_Small_and_Large_Cell_Lung_Carcinoma"                                                                                                                         
 [8865] "Conventional_Malignant_Hemangiopericytoma"                                                                                                                            
 [8866] "Conventional_Angiosarcoma"                                                                                                                                            
 [8867] "Conventional_Leiomyosarcoma"                                                                                                                                          
 [8868] "Conventional_Fibrosarcoma"                                                                                                                                            
 [8869] "Pigmented_Dermatofibrosarcoma_Protuberans_Bednar_Tumor"                                                                                                               
 [8870] "Childhood_Hematopoietic_Neoplasm"                                                                                                                                     
 [8871] "Malignant_Pleural_Effusion"                                                                                                                                           
 [8872] "Talc_Granuloma"                                                                                                                                                       
 [8873] "Infectious_Granuloma"                                                                                                                                                 
 [8874] "Granuloma_by_Site"                                                                                                                                                    
 [8875] "Radiation_Fibrosis"                                                                                                                                                   
 [8876] "Chronic_Renal_Failure"                                                                                                                                                
 [8877] "End_Stage_Renal_Disease"                                                                                                                                              
 [8878] "Abnormality"                                                                                                                                                          
 [8879] "AML_MDS"                                                                                                                                                              
 [8880] "Deposit"                                                                                                                                                              
 [8881] "Prior_Primary"                                                                                                                                                        
 [8882] "Rupture"                                                                                                                                                              
 [8883] "Grade_I_Colorectal_Adenocarcinoma"                                                                                                                                    
 [8884] "Grade_II_Colorectal_Adenocarcinoma"                                                                                                                                   
 [8885] "Grade_III_Colorectal_Adenocarcinoma"                                                                                                                                  
 [8886] "Grade_III_Rectal_Adenocarcinoma"                                                                                                                                      
 [8887] "Grade_II_Rectal_Adenocarcinoma"                                                                                                                                       
 [8888] "Grade_I_Rectal_Adenocarcinoma"                                                                                                                                        
 [8889] "Grade_I_Colon_Adenocarcinoma"                                                                                                                                         
 [8890] "Grade_II_Colon_Adenocarcinoma"                                                                                                                                        
 [8891] "Grade_III_Colon_Adenocarcinoma"                                                                                                                                       
 [8892] "Intermediate-Grade_Ductal_Carcinoma_In_Situ_of_the_Breast"                                                                                                            
 [8893] "Low-Grade_Ductal_Carcinoma_In_Situ_of_the_Breast"                                                                                                                     
 [8894] "Proliferating_Brenner_Tumor"                                                                                                                                          
 [8895] "Borderline_Brenner_Tumor"                                                                                                                                             
 [8896] "Cockayne_Syndrome"                                                                                                                                                    
 [8897] "Bladder_Small_Cell_Neuroendocrine_Carcinoma"                                                                                                                          
 [8898] "Laryngeal_Adenoid_Cystic_Carcinoma"                                                                                                                                   
 [8899] "Laryngeal_Mucoepidermoid_Carcinoma"                                                                                                                                   
 [8900] "Grade_1_Diffuse_Follicle_Center_Lymphoma"                                                                                                                             
 [8901] "Hypopharyngeal_Carcinoma"                                                                                                                                             
 [8902] "Pharyngeal_Carcinoma"                                                                                                                                                 
 [8903] "Chronic_Cancer_Pain"                                                                                                                                                  
 [8904] "C3_Deficiency"                                                                                                                                                        
 [8905] "C5_Deficiency"                                                                                                                                                        
 [8906] "Systemic_Anaplastic_Large_Cell_Lymphoma"                                                                                                                              
 [8907] "Childhood_Systemic_Anaplastic_Large_Cell_Lymphoma"                                                                                                                    
 [8908] "Atypical_Gastric_Lymphoid_Hyperplasia"                                                                                                                                
 [8909] "Lactating_Adenoma"                                                                                                                                                    
 [8910] "Mullerian_Adenosarcoma"                                                                                                                                               
 [8911] "Cerebellar_Astrocytoma"                                                                                                                                               
 [8912] "Desmoplastic_Infantile_Astrocytoma"                                                                                                                                   
 [8913] "Anaplastic_Astrocytoma"                                                                                                                                               
 [8914] "Atypia"                                                                                                                                                               
 [8915] "Familial_Cancer"                                                                                                                                                      
 [8916] "Invasive_Carcinoma"                                                                                                                                                   
 [8917] "Primary_Carcinoma"                                                                                                                                                    
 [8918] "Extraskeletal_Chondroma"                                                                                                                                              
 [8919] "Pineal_Gland_Cyst"                                                                                                                                                    
 [8920] "Chromosomal_Deletion"                                                                                                                                                 
 [8921] "Anosognostic_Epilepsy"                                                                                                                                                
 [8922] "Intractable_Epilepsy"                                                                                                                                                 
 [8923] "Genitourinary_Fistula"                                                                                                                                                
 [8924] "Sarcoidal_Granuloma"                                                                                                                                                  
 [8925] "Schistosome_Granuloma"                                                                                                                                                
 [8926] "Ductal_Breast_Hyperplasia"                                                                                                                                            
 [8927] "Hypochondria"                                                                                                                                                         
 [8928] "Latent_Infection"                                                                                                                                                     
 [8929] "Radial_Scar"                                                                                                                                                          
 [8930] "T-Cell_Histiocyte_Rich_Lymphoma"                                                                                                                                      
 [8931] "Melanotic_Medulloblastoma"                                                                                                                                            
 [8932] "Melanocytoma"                                                                                                                                                         
 [8933] "Melanomatosis"                                                                                                                                                        
 [8934] "Micrometastasis"                                                                                                                                                      
 [8935] "Myolipoma"                                                                                                                                                            
 [8936] "Juvenile_Breast_Papillomatosis"                                                                                                                                       
 [8937] "Stage_IVS_Neuroblastoma"                                                                                                                                              
 [8938] "Dysembryoplastic_Neuroepithelial_Tumor"                                                                                                                               
 [8939] "Tegafur_Uracil"                                                                                                                                                       
 [8940] "Cytarabine_Doxorubicin"                                                                                                                                               
 [8941] "Bleomycin_Dacarbazine_Doxorubicin_Vincristine"                                                                                                                        
 [8942] "Bleomycin_Dacarbazine_Doxorubicin_Vinblastine"                                                                                                                        
 [8943] "Cyclophosphamide_Doxorubicin"                                                                                                                                         
 [8944] "Cyclophosphamide_Dactinomycin_Fluorouracil"                                                                                                                           
 [8945] "Melphalan_Thiotepa"                                                                                                                                                   
 [8946] "Dacarbazine_Doxorubicin"                                                                                                                                              
 [8947] "Cytarabine_Doxorubicin_Prednisone_Vincristine"                                                                                                                        
 [8948] "Doxorubicin_Fluorouracil_Methotrexate"                                                                                                                                
 [8949] "Amsacrine_Cytarabine_Prednisone_Vincristine"                                                                                                                          
 [8950] "Cyclophosphamide_Doxorubicin_Methotrexate_Vincristine"                                                                                                                
 [8951] "Cisplatin_Doxorubicin_Vindesine"                                                                                                                                      
 [8952] "Amsacrine_Cytarabine_Thioguanine"                                                                                                                                     
 [8953] "Doxorubicin_Mitomycin_Vinblastine"                                                                                                                                    
 [8954] "Bleomycin_Dacarbazine_Doxorubicin_Prednisone_Vincristine"                                                                                                             
 [8955] "Bleomycin_Doxorubicin_Lomustine_Mechlorethamine_Vincristine"                                                                                                          
 [8956] "Bleomycin_Cyclophosphamide_Dactinomycin"                                                                                                                              
 [8957] "Carmustine_Cyclophosphamide_Prednisone"                                                                                                                               
 [8958] "Carmustine_Cyclophosphamide_Prednisone_Vincristine"                                                                                                                   
 [8959] "Bleomycin_Cisplatin_Etoposide"                                                                                                                                        
 [8960] "Cyclophosphamide_Cytarabine_Doxorubicin_Methotrexate_Prednisone_Thioguanine_Vincristine"                                                                              
 [8961] "Bleomycin_Cisplatin_Ifosfamide"                                                                                                                                       
 [8962] "Bleomycin_Cisplatin_Mitomycin_Vincristine"                                                                                                                            
 [8963] "Carmustine_Cyclophosphamide_Prednisone_Procarbazine_Vinblastine"                                                                                                      
 [8964] "Lomustine_Methotrexate_Procarbazine"                                                                                                                                  
 [8965] "Carboplatin_Cyclophosphamide"                                                                                                                                         
 [8966] "Cyclophosphamide_Doxorubicin_Fluorouracil"                                                                                                                            
 [8967] "Cyclophosphamide_Doxorubicin_Fluorouracil_Prednisone_Vincristine"                                                                                                     
 [8968] "Cyclophosphamide_Doxorubicin_Methotrexate"                                                                                                                            
 [8969] "Cyclophosphamide_Doxorubicin_Etoposide_Methotrexate_Vincristine"                                                                                                      
 [8970] "Cyclophosphamide_Doxorubicin_Fluorouracil_Methotrexate"                                                                                                               
 [8971] "Cyclophosphamide_Doxorubicin_Methotrexate_Procarbazine"                                                                                                               
 [8972] "Cisplatin_Cyclophosphamide_Doxorubicin_Fluorouracil"                                                                                                                  
 [8973] "Cyclophosphamide_Doxorubicin_Vincristine"                                                                                                                             
 [8974] "Carmustine_Cyclophosphamide_Etoposide"                                                                                                                                
 [8975] "Cyclophosphamide_Lomustine_Methotrexate_Vincristine"                                                                                                                  
 [8976] "Cyclophosphamide_Lomustine_Vincristine"                                                                                                                               
 [8977] "Cyclophosphamide_Doxorubicin_Lomustine_Vincristine"                                                                                                                   
 [8978] "Cisplatin_Cyclophosphamide_Epirubicin"                                                                                                                                
 [8979] "Cyclophosphamide_Epirubicin_Vincristine"                                                                                                                              
 [8980] "Cyclophosphamide_Fluorouracil"                                                                                                                                        
 [8981] "Cyclophosphamide_Fluorouracil_Prednisone"                                                                                                                             
 [8982] "Cyclophosphamide_Doxorubicin_Prednisone_Vincristine"                                                                                                                  
 [8983] "Bleomycin_Cyclophosphamide_Doxorubicin_Prednisone_Vincristine"                                                                                                        
 [8984] "Cyclophosphamide_Doxorubicin_Prednisone_Teniposide"                                                                                                                   
 [8985] "Cisplatin_Fluorouracil_Methotrexate"                                                                                                                                  
 [8986] "Bleomycin_Cyclophosphamide_Fluorouracil_Methotrexate"                                                                                                                 
 [8987] "Cyclophosphamide_Doxorubicin_Fluorouracil_Methotrexate_Vincristine"                                                                                                   
 [8988] "Cyclophosphamide_Fluorouracil_Methotrexate_Prednisone"                                                                                                                
 [8989] "Cyclophosphamide_Fluorouracil_Methotrexate_Prednisone_Tamoxifen"                                                                                                      
 [8990] "Cyclophosphamide_Fluorouracil_Methotrexate_Prednisone_Vincristine"                                                                                                    
 [8991] "Cyclophosphamide_Cytarabine_Prednisone_Vincristine"                                                                                                                   
 [8992] "Bleomycin_Cisplatin_Vincristine"                                                                                                                                      
 [8993] "Cyclophosphamide_Fluorouracil_Vincristine"                                                                                                                            
 [8994] "Cyclophosphamide_Fluorouracil_Methotrexate_Vincristine"                                                                                                               
 [8995] "Cyclophosphamide_Methotrexate_Prednisone_Vincristine"                                                                                                                 
 [8996] "Bleomycin_Cyclophosphamide_Prednisone_Vincristine"                                                                                                                    
 [8997] "Bleomycin_Cyclophosphamide_Doxorubicin_Prednisone_Procarbazine_Vincristine"                                                                                           
 [8998] "Cisplatin_Cyclophosphamide_Doxorubicin_Lomustine_Vincristine"                                                                                                         
 [8999] "Asparaginase_Cyclophosphamide_Cytarabine_Doxorubicin_Methotrexate_Prednisone_Vincristine"                                                                             
 [9000] "Cyclophosphamide_Prednisone_Procarbazine_Vincristine"                                                                                                                 
 [9001] "Cytarabine_Hydrocortisone"                                                                                                                                            
 [9002] "Cisplatin_Cyclophosphamide"                                                                                                                                           
 [9003] "Altretamine_Cisplatin_Cyclophosphamide_Doxorubicin"                                                                                                                   
 [9004] "Bleomycin_Cisplatin_Vindesine"                                                                                                                                        
 [9005] "Cyclophosphamide_Dacarbazine_Vincristine"                                                                                                                             
 [9006] "Cyclophosphamide_Prednisone_Vincristine"                                                                                                                              
 [9007] "Cyclophosphamide_Prednisone_Procarbazine_Vinblastine"                                                                                                                 
 [9008] "Lomustine_Prednisone_Procarbazine_Vinblastine"                                                                                                                        
 [9009] "Cyclophosphamide_Dacarbazine_Doxorubicin_Vincristine"                                                                                                                 
 [9010] "Cytarabine_Daunorubicin_Thioguanine"                                                                                                                                  
 [9011] "Cytarabine_Daunorubicin_Prednisone_Thioguanine_Vincristine"                                                                                                           
 [9012] "Cytarabine_Daunorubicin_Etoposide"                                                                                                                                    
 [9013] "Doxorubicin_Fluoxymesterone_Mitolactol_Vincristine"                                                                                                                   
 [9014] "Cytarabine_Daunorubicin_Mercaptopurine_Prednisolone"                                                                                                                  
 [9015] "Bleomycin_Cisplatin"                                                                                                                                                  
 [9016] "Cisplatin_Cytarabine_Dexamethasone"                                                                                                                                   
 [9017] "Doxorubicin_Procarbazine_Prednisone_Vincristine"                                                                                                                      
 [9018] "Cisplatin_Doxorubicin_Etoposide"                                                                                                                                      
 [9019] "Carmustine_Doxorubicin_Prednisone_Vindesine"                                                                                                                          
 [9020] "Bleomycin_Epirubicin_Prednisone_Vinblastine"                                                                                                                          
 [9021] "Cyclophosphamide_Doxorubicin_Etoposide_Vincristine"                                                                                                                   
 [9022] "Cisplatin_Cytarabine_Dexamethasone_Etoposide"                                                                                                                         
 [9023] "Carmustine_Doxorubicin_Fluorouracil"                                                                                                                                  
 [9024] "Cisplatin_Cyclophosphamide_Doxorubicin_Tegafur"                                                                                                                       
 [9025] "Doxorubicin_Fluorouracil_Mitomycin"                                                                                                                                   
 [9026] "Cisplatin_Doxorubicin_Fluorouracil_Mitomycin"                                                                                                                         
 [9027] "Cisplatin_Doxorubicin_Fluorouracil"                                                                                                                                   
 [9028] "Cyclophosphamide_Epirubicin_Fluorouracil"                                                                                                                             
 [9029] "Fluorouracil_Mitomycin_Vincristine"                                                                                                                                   
 [9030] "Altretamine_Cisplatin_Doxorubicin"                                                                                                                                    
 [9031] "Altretamine_Cyclophosphamide_Fluorouracil_Methotrexate"                                                                                                               
 [9032] "Bleomycin_Cytarabine_Doxorubicin_Prednisone_Vincristine"                                                                                                              
 [9033] "Cisplatin_Doxorubicin_Ifosfamide"                                                                                                                                     
 [9034] "Etoposide_Ifosfamide_Methotrexate"                                                                                                                                    
 [9035] "Chlorambucil_Fluorouracil_Methotrexate"                                                                                                                               
 [9036] "Carmustine_Cyclophosphamide_Melphalan_Prednisone_Vincristine"                                                                                                         
 [9037] "Cisplatin_Doxorubicin_Methotrexate_Vinblastine"                                                                                                                       
 [9038] "Cisplatin_Epirubicin_Methotrexate_Vinblastine"                                                                                                                        
 [9039] "Cyclophosphamide_Dactinomycin_Methotrexate"                                                                                                                           
 [9040] "Cyclophosphamide_Doxorubicin_Lomustine_Methotrexate"                                                                                                                  
 [9041] "Cisplatin_Doxorubicin_Mitomycin"                                                                                                                                      
 [9042] "Bleomycin_Cisplatin_Methotrexate"                                                                                                                                     
 [9043] "Cyclophosphamide_Lomustine_Methotrexate"                                                                                                                              
 [9044] "Altretamine_Cisplatin_Etoposide_Mitomycin"                                                                                                                            
 [9045] "Cyclophosphamide_Methotrexate_Vincristine"                                                                                                                            
 [9046] "Cyclophosphamide_Doxorubicin_Methotrexate_Prednisone_Vincristine"                                                                                                     
 [9047] "Fluorouracil_Leucovorin-Calcium_Methotrexate"                                                                                                                         
 [9048] "Etoposide_Ifosfamide_Methotrexate_Mitoguazone"                                                                                                                        
 [9049] "Fluorouracil_Semustine_Vincristine"                                                                                                                                   
 [9050] "Fluorouracil_Semustine_Streptozocin_Vincristine"                                                                                                                      
 [9051] "Mechlorethamine_Procarbazine_Vincristine"                                                                                                                             
 [9052] "Mechlorethamine_Prednisone_Procarbazine_Vincristine"                                                                                                                  
 [9053] "Bleomycin_Doxorubicin_Mechlorethamine_Prednisone_Procarbazine_Vinblastine_Vincristine"                                                                                
 [9054] "Cyclophosphamide_Cytarabine_Doxorubicin_Methotrexate_Vincristine"                                                                                                     
 [9055] "Mechlorethamine_Prednisone_Procarbazine_Vinblastine_Vincristine"                                                                                                      
 [9056] "Cytarabine_Mitoxantrone"                                                                                                                                              
 [9057] "Cytarabine_Prednisone_Vincristine"                                                                                                                                    
 [9058] "Cyclophosphamide_Doxorubicin_Prednisone_Procarbazine_Vincristine"                                                                                                     
 [9059] "Bleomycin_Cisplatin_Cyclophosphamide_Doxorubicin"                                                                                                                     
 [9060] "Lomustine_Procarbazine_Vincristine"                                                                                                                                   
 [9061] "Cisplatin_Fluorouracil_Leucovorin-Calcium"                                                                                                                            
 [9062] "Cyclophosphamide_Lomustine_Procarbazine_Vincristine"                                                                                                                  
 [9063] "Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                                                                   
 [9064] "Ifosfamide_Methotrexate_Procarbazine"                                                                                                                                 
 [9065] "Bleomycin_Cyclophosphamide_Cytarabine_Doxorubicin_Etoposide_Methotrexate_Prednisone_Vincristine"                                                                      
 [9066] "Bleomycin_Cisplatin_Vinblastine"                                                                                                                                      
 [9067] "Asparaginase_Daunorubicin_Prednisone_Vincristine"                                                                                                                     
 [9068] "Bleomycin_Cisplatin_Etoposide_Vinblastine"                                                                                                                            
 [9069] "Cytarabine_Daunorubicin_Prednisone_Vincristine"                                                                                                                       
 [9070] "Bleomycin_Doxorubicin_Lomustine_Streptozocin"                                                                                                                         
 [9071] "Doxorubicin_Fluoxymesterone_Thiotepa_Vinblastine"                                                                                                                     
 [9072] "Bleomycin_Cisplatin_Dactinomycin_Vinblastine"                                                                                                                         
 [9073] "Bleomycin_Dactinomycin_Vinblastine"                                                                                                                                   
 [9074] "Bleomycin_Chlorambucil_Cisplatin_Cyclophosphamide_Dactinomycin_Vinblastine"                                                                                           
 [9075] "Cyclophosphamide_Dactinomycin_Vincristine"                                                                                                                            
 [9076] "Cyclophosphamide_Dactinomycin_Doxorubicin_Vincristine"                                                                                                                
 [9077] "Doxorubicin_Etoposide"                                                                                                                                                
 [9078] "Dexamethasone_Doxorubicin_Vincristine"                                                                                                                                
 [9079] "Doxorubicin_Procarbazine_Vincristine"                                                                                                                                 
 [9080] "Doxorubicin_Prednisone_Vincristine"                                                                                                                                   
 [9081] "Cyclophosphamide_Doxorubicin_Prednisolone_Vincristine"                                                                                                                
 [9082] "Cyclophosphamide_Cytarabine_Doxorubicin_Prednisone_Vincristine"                                                                                                       
 [9083] "Doxorubicin_Etoposide_Vincristine"                                                                                                                                    
 [9084] "Bleomycin_Doxorubicin_Vinblastine"                                                                                                                                    
 [9085] "Carmustine_Dexamethasone_Doxorubicin_Melphalan_Vincristine"                                                                                                           
 [9086] "Carmustine_Doxorubicin_Prednisone_Vincristine"                                                                                                                        
 [9087] "Bleomycin_Methotrexate_Vincristine"                                                                                                                                   
 [9088] "Cyclophosphamide_Prednisolone_Vincristine"                                                                                                                            
 [9089] "Daunorubicin_Prednisone_Vincristine"                                                                                                                                  
 [9090] "Cisplatin_Interleukin-2"                                                                                                                                              
 [9091] "Cyclophosphamide_Doxorubicin_Methotrexate_Prednisolone_Vincristine"                                                                                                   
 [9092] "Cisplatin_Etoposide_Ifosfamide"                                                                                                                                       
 [9093] "Bleomycin_Cisplatin_Methotrexate_Vincristine"                                                                                                                         
 [9094] "Cyclophosphamide_Melphalan_Prednisone_Vincristine"                                                                                                                    
 [9095] "Fluorouracil_Methotrexate_Vincristine"                                                                                                                                
 [9096] "Etoposide_Methotrexate_Vincristine"                                                                                                                                   
 [9097] "Prednisolone_Vincristine"                                                                                                                                             
 [9098] "Cisplatin_Etoposide"                                                                                                                                                  
 [9099] "Bleomycin_Dacarbazine_Doxorubicin_Lomustine_Prednisone"                                                                                                               
 [9100] "Cyclophosphamide_Dexamethasone_Doxorubicin_Vincristine"                                                                                                               
 [9101] "Fluorouracil_Mitomycin_Streptozocin"                                                                                                                                  
 [9102] "Cyclophosphamide_Cytarabine_Methotrexate_Vincristine"                                                                                                                 
 [9103] "Dactinomycin_Ifosfamide_Vincristine"                                                                                                                                  
 [9104] "Bleomycin_Carboplatin_Etoposide"                                                                                                                                      
 [9105] "Epirubicin_Fluorouracil_Mitomycin"                                                                                                                                    
 [9106] "Bleomycin_Cyclophosphamide_Dexamethasone_Methotrexate_Mitoxantrone_Vincristine"                                                                                       
 [9107] "Bleomycin_Cyclophosphamide_Dexamethasone_Doxorubicin_Methotrexate_Vincristine"                                                                                        
 [9108] "Amsacrine_Azacytidine_Etoposide"                                                                                                                                      
 [9109] "Chlorambucil_Dactinomycin_Methotrexate"                                                                                                                               
 [9110] "Cyclophosphamide_Cytarabine_Thioguanine"                                                                                                                              
 [9111] "Fluorouracil_Methotrexate_Mitoxantrone"                                                                                                                               
 [9112] "Cyclophosphamide_Doxorubicin_Etoposide_Mechlorethamine_Methotrexate_Prednisone_Procarbazine_Vincristine"                                                              
 [9113] "Cisplatin_Etoposide_Methotrexate"                                                                                                                                     
 [9114] "Asparaginase_Doxorubicin_Prednisone_Vincristine"                                                                                                                      
 [9115] "Cyclophosphamide_Doxorubicin_Fluorouracil_Vincristine"                                                                                                                
 [9116] "Carmustine_Cyclophosphamide_Cytarabine_Etoposide"                                                                                                                     
 [9117] "Cyclophosphamide_Doxorubicin_Etoposide"                                                                                                                               
 [9118] "Carboplatin_Cyclophosphamide_Thiotepa"                                                                                                                                
 [9119] "Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide_Vincristine"                                                                                                         
 [9120] "Carmustine_Cisplatin_Dacarbazine_Tamoxifen"                                                                                                                           
 [9121] "Cisplatin_Etoposide_Fluorouracil"                                                                                                                                     
 [9122] "Cisplatin_Etoposide_Vindesine"                                                                                                                                        
 [9123] "Cyclophosphamide_Fluorouracil_Mitoxantrone"                                                                                                                           
 [9124] "Asparaginase_Cyclophosphamide_Doxorubicin_Prednisolone_Vincristine"                                                                                                   
 [9125] "Cisplatin_Cyclophosphamide_Dacarbazine_Doxorubicin_Mechlorethamine_Vincristine"                                                                                       
 [9126] "Cisplatin_Etoposide_Vinblastine"                                                                                                                                      
 [9127] "Bleomycin_Cisplatin_Methotrexate_Vinblastine"                                                                                                                         
 [9128] "Doxorubicin_Fluoxymesterone_mitolactol_Tamoxifen_Vincristine"                                                                                                         
 [9129] "Carmustine_Cyclophosphamide_Doxorubicin_Melphalan"                                                                                                                    
 [9130] "Cyclophosphamide_Dacarbazine_Doxorubicin"                                                                                                                             
 [9131] "Bleomycin_Cyclophosphamide_Dexamethasone_Doxorubicin_Vincristine"                                                                                                     
 [9132] "Doxorubicin_Fluorouracil_Mitomycin_Streptozocin"                                                                                                                      
 [9133] "Cyclophosphamide_Etoposide_Methotrexate_Vincristine"                                                                                                                  
 [9134] "Melphalan_Procarbazine_Vinblastine"                                                                                                                                   
 [9135] "Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Vincristine"                                                                                                        
 [9136] "Fluorouracil_Methotrexate_Thiotepa"                                                                                                                                   
 [9137] "Cisplatin_Cyclophosphamide_Vindesine"                                                                                                                                 
 [9138] "Cisplatin_Doxorubicin_Ifosfamide_Methotrexate"                                                                                                                        
 [9139] "Fluorouracil_Leucovorin-Calcium_Mitoxantrone"                                                                                                                         
 [9140] "Cyclophosphamide_Etoposide_Vincristine"                                                                                                                               
 [9141] "Mitoxantrone_Prednisone_Procarbazine_Vincristine"                                                                                                                     
 [9142] "Bleomycin_Cyclophosphamide_Doxorubicin_Prednisone_Teniposide_Vincristine"                                                                                             
 [9143] "Doxorubicin_Etoposide_Vinblastine"                                                                                                                                    
 [9144] "Cyclophosphamide_Etoposide_Lomustine_Vincristine"                                                                                                                     
 [9145] "Bleomycin_Cyclophosphamide_Semustine_Vincristine"                                                                                                                     
 [9146] "Cyclophosphamide_Etoposide"                                                                                                                                           
 [9147] "Cisplatin_Cyclophosphamide_Etoposide_Vincristine"                                                                                                                     
 [9148] "Cisplatin_Cyclophosphamide_Mitoxantrone"                                                                                                                              
 [9149] "Melphalan_Prednisone"                                                                                                                                                 
 [9150] "Cisplatin_Methotrexate_Vinblastine"                                                                                                                                   
 [9151] "Cisplatin_Dacarbazine_Vinblastine"                                                                                                                                    
 [9152] "Cisplatin_Doxorubicin_Vincristine"                                                                                                                                    
 [9153] "Cisplatin_Cytarabine_Etoposide_Methylprednisolone"                                                                                                                    
 [9154] "Cyclophosphamide_Doxorubicin_Etoposide_Methotrexate_Prednisolone_Vincristine"                                                                                         
 [9155] "Amsacrine_Cytarabine_Etoposide"                                                                                                                                       
 [9156] "Cytarabine_Etoposide_Mitoxantrone"                                                                                                                                    
 [9157] "Doxorubicin_Etoposide_Procarbazine_Vincristine"                                                                                                                       
 [9158] "Altretamine_Mitomycin_Vinblastine"                                                                                                                                    
 [9159] "Doxorubicin_Fluorouracil_Leucovorin-Calcium"                                                                                                                          
 [9160] "Cisplatin_Ifosfamide_Vincristine"                                                                                                                                     
 [9161] "Carboplatin_Doxorubicin_Etoposide"                                                                                                                                    
 [9162] "Cyclophosphamide_Bleomycin_Epirubicin_Prednisone_Vincristine"                                                                                                         
 [9163] "Cisplatin_Cytarabine_Doxorubicin_Methylprednisolone"                                                                                                                  
 [9164] "Bleomycin_Doxorubicin_Etoposide_Mechlorethamine_Prednisone_Vinblastine_Vincristine"                                                                                   
 [9165] "Carmustine_Cyclophosphamide_Etoposide_Hydroxyurea"                                                                                                                    
 [9166] "Cisplatin_Doxorubicin_Methotrexate"                                                                                                                                   
 [9167] "Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide"                                                                                                                     
 [9168] "Ifosfamide_Cyclophosphamide_Etoposide"                                                                                                                                
 [9169] "Estradiol_Norethindrone"                                                                                                                                              
 [9170] "Asparaginase_Cyclophosphamide_Daunorubicin_Dexamethasone_Methotrexate_Vincristine"                                                                                    
 [9171] "Doxorubicin_Vincristine_VX-710"                                                                                                                                       
 [9172] "Carboplatin_Cyclophosphamide_Vincristine"                                                                                                                             
 [9173] "Docetaxol_Vinblastine"                                                                                                                                                
 [9174] "Docetaxol_Etoposide"                                                                                                                                                  
 [9175] "Docetaxol_cyclophosphamide"                                                                                                                                           
 [9176] "Cyclophosphamide_Doxorubicin_Uracil_Tegafur_Tamoxifen"                                                                                                                
 [9177] "Doxifluridine_L-Leucovorin"                                                                                                                                           
 [9178] "Carboplatin_Etoposide_Cyclophosphamide_Thiotepa"                                                                                                                      
 [9179] "Docetaxel_Vincristine"                                                                                                                                                
 [9180] "Docetaxel_Vinblastine"                                                                                                                                                
 [9181] "Cyclophosphamide_Doxorubicin_Fluorouracil_Tegafur_Tamoxifen"                                                                                                          
 [9182] "Paclitaxel_Cisplatin_Topotecan_G-CSF"                                                                                                                                 
 [9183] "Lovastatin_Sulindac"                                                                                                                                                  
 [9184] "Maxamine_Interleukin-2"                                                                                                                                               
 [9185] "Maxamine_Interferon-Alpha"                                                                                                                                            
 [9186] "Fluorouracil_Mitomycin-C_Cisplatin"                                                                                                                                   
 [9187] "Etoposide_Fluorouracil_Folinic-Acid"                                                                                                                                  
 [9188] "Epirubicin_Folinic-Acid_Fluorouracil_Etoposide"                                                                                                                       
 [9189] "Paclitaxel_Beta-Lapachone"                                                                                                                                            
 [9190] "Thymalfasin_Dacarbazine"                                                                                                                                              
 [9191] "Vitamin-E_Fluorouracil"                                                                                                                                               
 [9192] "Herceptin_Paclitaxel"                                                                                                                                                 
 [9193] "Rituximab_Cyclophosphamide_Doxorubicin_Prednisone_Vincristine"                                                                                                        
 [9194] "Fluorouracil_Leucovorin_Rhumab-Vegf"                                                                                                                                  
 [9195] "L-744-832_Paclitaxel"                                                                                                                                                 
 [9196] "p53-Adenovirus_SCH-66336"                                                                                                                                             
 [9197] "_16-88_88BV59"                                                                                                                                                        
 [9198] "Cytarabine_Etoposide_Idarubicin"                                                                                                                                      
 [9199] "Cyclophosphamide_Thiotepa"                                                                                                                                            
 [9200] "Cyclophosphamide_Doxorubicin_Fluorouracil_Fluoxymesterone_Interferon-alfa_Tamoxifen"                                                                                  
 [9201] "Cisplatin_Mitomycin"                                                                                                                                                  
 [9202] "Amsacrine_Cytarabine"                                                                                                                                                 
 [9203] "Azacytidine_Etoposide"                                                                                                                                                
 [9204] "Cyclophosphamide_Doxorubicin_Etoposide_Methotrexate_Prednisone"                                                                                                       
 [9205] "Bleomycin_Lomustine_Methotrexate"                                                                                                                                     
 [9206] "Bleomycin_Lomustine_Methotrexate_Vinblastine"                                                                                                                         
 [9207] "Busulfan_Cyclophosphamide"                                                                                                                                            
 [9208] "Amsacrine_Cyclophosphamide_Etoposide"                                                                                                                                 
 [9209] "Cisplatin_Cytarabine"                                                                                                                                                 
 [9210] "Cyclophosphamide_Doxorubicin_Prednisone"                                                                                                                              
 [9211] "Etoposide_Vincristine"                                                                                                                                                
 [9212] "Interferon-Gamma_Interleukin-2"                                                                                                                                       
 [9213] "Asparaginase_Mercaptopurine_Prednisone_Vincristine"                                                                                                                   
 [9214] "Cytarabine_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                                                        
 [9215] "Bleomycin_Carboplatin"                                                                                                                                                
 [9216] "Carmustine_Cisplatin_Cyclophosphamide"                                                                                                                                
 [9217] "Fluorouracil_Idoxuridine"                                                                                                                                             
 [9218] "Asparaginase_Etoposide_Prednisone_Vincristine"                                                                                                                        
 [9219] "Fluorouracil_Methylmercaptopurine-Riboside_PALA"                                                                                                                      
 [9220] "Doxorubicin_Interleukin-2"                                                                                                                                            
 [9221] "Mechlorethamine_Prednisone_Procarbazine_Vinblastine"                                                                                                                  
 [9222] "Cyclophosphamide_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                                                  
 [9223] "Busulfan_Cyclophosphamide_Etoposide"                                                                                                                                  
 [9224] "Fluorouracil_Leucovorin-Calcium"                                                                                                                                      
 [9225] "Carboplatin_Cisplatin"                                                                                                                                                
 [9226] "Carmustine_Cisplatin_Etoposide"                                                                                                                                       
 [9227] "Cisplatin_Mitolactol"                                                                                                                                                 
 [9228] "Asparaginase_Cytarabine"                                                                                                                                              
 [9229] "Cytarabine_Methotrexate_Methylprednisolone"                                                                                                                           
 [9230] "Asparaginase_Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Methotrexate_Thioguanine_Vincristine"                                                              
 [9231] "Cyclophosphamide_Etoposide_Methotrexate"                                                                                                                              
 [9232] "Cyproterone_Goserelin"                                                                                                                                                
 [9233] "Cyclophosphamide_Cytarabine_Doxorubicin_Hydroxyurea_Lomustine_Methotrexate_Thioguanine_Vincristine"                                                                   
 [9234] "Cisplatin_Dacarbazine"                                                                                                                                                
 [9235] "Interferon-Beta_Interleukin-2"                                                                                                                                        
 [9236] "Interferon-Beta_Interferon-Gamma"                                                                                                                                     
 [9237] "Goserelin_Nilutamide"                                                                                                                                                 
 [9238] "Flutamide_Goserelin"                                                                                                                                                  
 [9239] "Dacarbazine_Etoposide_Hydroxyurea"                                                                                                                                    
 [9240] "Carboplatin_Fluorouracil"                                                                                                                                             
 [9241] "Carboplatin_Etoposide_Thiotepa"                                                                                                                                       
 [9242] "Asparaginase_Cyclophosphamide_Cytarabine_Methotrexate_Prednisone_Thioguanine_Vincristine"                                                                             
 [9243] "Carmustine_Cyclophosphamide_Dactinomycin_Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                              
 [9244] "Cisplatin_Thiotepa"                                                                                                                                                   
 [9245] "Carboplatin_Cisplatin_Cyclophosphamide"                                                                                                                               
 [9246] "Fluorouracil_Leucovorin-Calcium_Levamisole"                                                                                                                           
 [9247] "Asparaginase_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                                                      
 [9248] "Asparaginase_Doxorubicin_Mercaptopurine_Prednisone_Vincristine"                                                                                                       
 [9249] "Fluorouracil_Methotrexate_Mitomycin"                                                                                                                                  
 [9250] "Mercaptopurine_Methotrexate_Prednisone_Vindesine"                                                                                                                     
 [9251] "Doxorubicin_Ifosfamide"                                                                                                                                               
 [9252] "Cyclophosphamide_Doxorubicin_Interferon-alfa_Interleukin-2_Lymphokine-Activated-Killer-Cells"                                                                         
 [9253] "Cisplatin_Teniposide"                                                                                                                                                 
 [9254] "Cisplatin_Cytarabine_Etoposide_Vinblastine"                                                                                                                           
 [9255] "Ifosfamide_Lomustine_Vinblastine"                                                                                                                                     
 [9256] "Bleomycin_Lomustine"                                                                                                                                                  
 [9257] "Doxorubicin_Floxuridine"                                                                                                                                              
 [9258] "Asparaginase_Daunorubicin_Methotrexate_Prednisone_Vincristine"                                                                                                        
 [9259] "Cyclophosphamide_Cytarabine_Mercaptopurine_Methotrexate"                                                                                                              
 [9260] "Asparaginase_Methotrexate_Prednisone_Vincristine"                                                                                                                     
 [9261] "Dexamethasone_Methotrexate_Thioguanine"                                                                                                                               
 [9262] "Asparaginase_Cyclophosphamide_Cytarabine_Doxorubicin_Methotrexate_Thioguanine_Vincristine"                                                                            
 [9263] "Fluorouracil_Streptozocin"                                                                                                                                            
 [9264] "Doxorubicin_Mitolactol"                                                                                                                                               
 [9265] "Amsacrine_Etoposide"                                                                                                                                                  
 [9266] "Cyclophosphamide_Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                                      
 [9267] "Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                                                       
 [9268] "Buserelin_Tamoxifen"                                                                                                                                                  
 [9269] "Asparaginase_Cyclophosphamide_Doxorubicin_Prednisone_Vincristine"                                                                                                     
 [9270] "Cytarabine_Idarubicin"                                                                                                                                                
 [9271] "Mercaptopurine_Methotrexate_Pentostatin"                                                                                                                              
 [9272] "Cyclophosphamide_Fluorouracil_Menogaril"                                                                                                                              
 [9273] "Aminoglutethimide_Megestrol"                                                                                                                                          
 [9274] "Cisplatin_Trimetrexate-Glucuronate"                                                                                                                                   
 [9275] "Etoposide_Trimetrexate-Glucuronate"                                                                                                                                   
 [9276] "Carmustine_Cisplatin"                                                                                                                                                 
 [9277] "Prednisone_Vincristine"                                                                                                                                               
 [9278] "Asparaginase_Cytarabine_Daunorubicin_Methotrexate_Prednisone_Teniposide_Vincristine"                                                                                  
 [9279] "Etoposide_Ifosfamide_Vincristine"                                                                                                                                     
 [9280] "Cytarabine_Sargramostim"                                                                                                                                              
 [9281] "Amsacrine_Cytarabine_Daunorubicin"                                                                                                                                    
 [9282] "Cyclophosphamide_Cytarabine_Vincristine"                                                                                                                              
 [9283] "Buserelin_Cyproterone"                                                                                                                                                
 [9284] "Dexamethasone_Methotrexate_Zidovudine"                                                                                                                                
 [9285] "Doxorubicin_Ifosfamide_Sargramostim"                                                                                                                                  
 [9286] "Cisplatin_Etoposide_Interleukin-2_Lymphokine-Activated-Killer-Cells"                                                                                                  
 [9287] "Doxorubicin_Prednisone"                                                                                                                                               
 [9288] "Doxorubicin_Etoposide_Quinidine"                                                                                                                                      
 [9289] "Fluorouracil_Methotrexate_Tamoxifen"                                                                                                                                  
 [9290] "Etoposide_Methotrexate_Mitomycin"                                                                                                                                     
 [9291] "Cyclophosphamide_Etanidazole"                                                                                                                                         
 [9292] "Fludarabine_Pentostatin"                                                                                                                                              
 [9293] "Diaziquone_Mitoxantrone"                                                                                                                                              
 [9294] "Pegaspargase_Prednisone_Vincristine"                                                                                                                                  
 [9295] "Diaziquone_Etoposide"                                                                                                                                                 
 [9296] "Etoposide_Mitoxantrone"                                                                                                                                               
 [9297] "Cisplatin_Cyclophosphamide_Melphalan"                                                                                                                                 
 [9298] "Cyclophosphamide_Doxorubicin_Methylprednisolone_Prednisone_Vincristine"                                                                                               
 [9299] "Asparaginase_Cytarabine_Doxorubicin_Teniposide"                                                                                                                       
 [9300] "Cyclophosphamide_Cytarabine_Teniposide"                                                                                                                               
 [9301] "Asparaginase_Dexamethasone_Doxorubicin_Vincristine"                                                                                                                   
 [9302] "Asparaginase_Cyclophosphamide_Daunorubicin_Prednisone_Vincristine"                                                                                                    
 [9303] "Asparaginase_Cytarabine_Carmustine_Thioguanine"                                                                                                                       
 [9304] "Carmustine_Cyclophosphamide_Cytarabine_Daunorubicin_Hydroxyurea_Methotrexate_Thioguanine_Vincristine"                                                                 
 [9305] "Asparaginase_Cytarabine_Methotrexate_Prednisone_Thioguanine_Vincristine"                                                                                              
 [9306] "Cyclophosphamide_Cytarabine_Mercaptopurine"                                                                                                                           
 [9307] "Cyclophosphamide_Fluorouracil_Methotrexate"                                                                                                                           
 [9308] "Cisplatin_Cytarabine_Etoposide"                                                                                                                                       
 [9309] "Cytarabine_Mercaptopurine_Methotrexate"                                                                                                                               
 [9310] "Indomethacin_Interleukin-1-Alpha"                                                                                                                                     
 [9311] "Carboplatin_Cyclophosphamide_Etoposide"                                                                                                                               
 [9312] "Cyclophosphamide_Interleukin-2_Tumor-Necrosis-Factor"                                                                                                                 
 [9313] "Mitoxantrone_Sargramostim"                                                                                                                                            
 [9314] "Dexrazoxane_Doxorubicin_Sargramostim"                                                                                                                                 
 [9315] "Cyclophosphamide_Diaziquone"                                                                                                                                          
 [9316] "Cytarabine_Daunorubicin_Etoposide_Sargramostim"                                                                                                                       
 [9317] "Chlorambucil_Pentostatin_Prednisone"                                                                                                                                  
 [9318] "Cisplatin_Mitotane"                                                                                                                                                   
 [9319] "Bleomycin_Cyclophosphamide_Doxorubicin_Methotrexate_Methylprednisolone_Vincristine"                                                                                   
 [9320] "Etoposide_Mitoxantrone_Prednimustine"                                                                                                                                 
 [9321] "Cisplatin_Melphalan"                                                                                                                                                  
 [9322] "Cytarabine_Doxorubicin_Thioguanine"                                                                                                                                   
 [9323] "Etoposide_Ifosfamide_Sargramostim"                                                                                                                                    
 [9324] "Etoposide_Filgrastim_Ifosfamide"                                                                                                                                      
 [9325] "Etoposide_Ifosfamide_Interleukin-3"                                                                                                                                   
 [9326] "Cyclophosphamide_Doxorubicin_Methotrexate_Sargramostim_Vincristine"                                                                                                   
 [9327] "Cytarabine_Etoposide_Ifosfamide"                                                                                                                                      
 [9328] "Cytarabine_Etoposide_Ifosfamide_Sargramostim"                                                                                                                         
 [9329] "Bleomycin_Doxorubicin_Vincristine_Zidovudine"                                                                                                                         
 [9330] "Cisplatin_Cyclophosphamide_Diethyldithiocarbamate"                                                                                                                    
 [9331] "Cisplatin_Fluorouracil_Vincristine"                                                                                                                                   
 [9332] "Carmustine_Cisplatin_Dacarbazine_Interleukin-2_Tamoxifen"                                                                                                             
 [9333] "Cisplatin_Cyclophosphamide_Dacarbazine_Doxorubicin_Etoposide_Vincristine"                                                                                             
 [9334] "Medroxyprogesterone_Tamoxifen"                                                                                                                                        
 [9335] "Cisplatin_Doxorubicin_Octreotide"                                                                                                                                     
 [9336] "Floxuridine_Streptozocin"                                                                                                                                             
 [9337] "Floxuridine_Octreotide_Streptozocin"                                                                                                                                  
 [9338] "Asparaginase_Cytarabine_Dexamethasone_Doxorubicin_Thioguanine_Vincristine"                                                                                            
 [9339] "Etoposide_Melphalan"                                                                                                                                                  
 [9340] "Bleomycin_Cyclophosphamide_Doxorubicin_Mitomycin"                                                                                                                     
 [9341] "Altretamine_Cyclophosphamide_Doxorubicin_Vincristine"                                                                                                                 
 [9342] "Altretamine_Fluorouracil_Mitomycin"                                                                                                                                   
 [9343] "Doxorubicin_Ifosfamide_Prednisone_Vincristine"                                                                                                                        
 [9344] "Etoposide_Lomustine_Methotrexate_Prednisone"                                                                                                                          
 [9345] "Doxorubicin_Mitomycin"                                                                                                                                                
 [9346] "Altretamine_Carmustine_Mitomycin"                                                                                                                                     
 [9347] "Cyclophosphamide_Doxorubicin_Mitomycin"                                                                                                                               
 [9348] "Asparaginase_Dexamethasone_Methotrexate_Vincristine"                                                                                                                  
 [9349] "Cisplatin_Novobiocin"                                                                                                                                                 
 [9350] "Cisplatin_Cytarabine_Dexamethasone_Doxorubicin"                                                                                                                       
 [9351] "Doxorubicin_Methotrexate_Prednisone_Vincristine"                                                                                                                      
 [9352] "Fluorouracil_Hydroxyurea_Leucovorin-Calcium"                                                                                                                          
 [9353] "Interleukin-2_Interleukin-4"                                                                                                                                          
 [9354] "Carmustine_Thymidine"                                                                                                                                                 
 [9355] "Asparaginase_Cyclophosphamide_Cytarabine_Prednisone_Vincristine"                                                                                                      
 [9356] "Asparaginase_Cyclophosphamide_Prednisone_Vincristine"                                                                                                                 
 [9357] "Carboplatin_Sargramostim"                                                                                                                                             
 [9358] "Cyclophosphamide_Doxorubicin_Tamoxifen"                                                                                                                               
 [9359] "Doxorubicin_Ifosfamide_Methotrexate"                                                                                                                                  
 [9360] "Doxorubicin_Ifosfamide_Vincristine"                                                                                                                                   
 [9361] "Dexamethasone_Methotrexate_Procarbazine_Teniposide"                                                                                                                   
 [9362] "Cisplatin_Doxorubicin"                                                                                                                                                
 [9363] "Methotrexate_Piritrexim"                                                                                                                                              
 [9364] "Asparaginase_Ifosfamide_Methotrexate"                                                                                                                                 
 [9365] "Bleomycin_Cytarabine_Prednisone_Vincristine"                                                                                                                          
 [9366] "Chlorambucil_Dacarbazine_Dactinomycin_Doxorubicin_Methotrexate_Vincristine"                                                                                           
 [9367] "Cytarabine_Methotrexate_Prednisone_Vincristine"                                                                                                                       
 [9368] "Cisplatin_Dianhydrogalactitol_Doxorubicin_Vincristine"                                                                                                                
 [9369] "Prednisone_Procarbazine_Vincristine"                                                                                                                                  
 [9370] "Cyclophosphamide_Doxorubicin_Prednisone_Tamoxifen"                                                                                                                    
 [9371] "Bleomycin_Doxorubicin_Lomustine_Vincristine"                                                                                                                          
 [9372] "Fluorouracil_Interleukin-2_Leucovorin-Calcium"                                                                                                                        
 [9373] "Cisplatin_Cyclophosphamide_Etoposide_Sargramostim"                                                                                                                    
 [9374] "Carboplatin_Ifosfamide_Vincristine"                                                                                                                                   
 [9375] "Bleomycin_Doxorubicin_Prednisone"                                                                                                                                     
 [9376] "Fluorouracil_Melphalan_Tamoxifen"                                                                                                                                     
 [9377] "Bleomycin_Doxorubicin_Mechlorethamine_Methotrexate_Vincristine"                                                                                                       
 [9378] "Dipyridamole_Fluorouracil_Leucovorin-Calcium"                                                                                                                         
 [9379] "Bleomycin_Doxorubicin_Streptozocin_Vincristine"                                                                                                                       
 [9380] "Bleomycin_Cyclophosphamide_Etoposide_Prednisone_Procarbazine"                                                                                                         
 [9381] "Asparaginase_Cyclophosphamide_Cytarabine_Mercaptopurine_Vincristine"                                                                                                  
 [9382] "Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Thioguanine_Vincristine"                                                                                        
 [9383] "Dapsone_Trimetrexate-Glucuronate"                                                                                                                                     
 [9384] "Carmustine_Dacarbazine_Hydroxyurea"                                                                                                                                   
 [9385] "Carmustine_Dacarbazine_Hydroxyurea_Vincristine"                                                                                                                       
 [9386] "Cyclophosphamide_Doxorubicin_Fluorouracil_Fluoxymesterone_Tamoxifen"                                                                                                  
 [9387] "Pentamidine_Trimetrexate-Glucuronate"                                                                                                                                 
 [9388] "Interferon-Beta_Zidovudine"                                                                                                                                           
 [9389] "Carmustine_Procarbazine_Vincristine"                                                                                                                                  
 [9390] "Cisplatin_Etoposide_Melphalan"                                                                                                                                        
 [9391] "Bleomycin_Methotrexate_Vinblastine"                                                                                                                                   
 [9392] "Bleomycin_Mechlorethamine_Prednisone_Procarbazine_Vincristine"                                                                                                        
 [9393] "Cisplatin_Cytarabine_Dacarbazine_Hydroxyurea_Lomustine_Methylprednisolone_Procarbazine_Vincristine"                                                                   
 [9394] "Bleomycin_Cyclophosphamide_Lomustine_Prednisone_Procarbazine_Vincristine"                                                                                             
 [9395] "Lomustine_Prednisolone_Vincristine"                                                                                                                                   
 [9396] "Carmustine_Methotrexate_Procarbazine"                                                                                                                                 
 [9397] "Doxorubicin_Semustine_Streptozocin"                                                                                                                                   
 [9398] "Cisplatin_Cyclophosphamide_Doxorubicin_Triazinate"                                                                                                                    
 [9399] "Doxorubicin_Fluoxymesterone_Tamoxifen_Thiotepa_Vinblastine"                                                                                                           
 [9400] "Cyclophosphamide_Sargramostim"                                                                                                                                        
 [9401] "Interleukin-2_Thiotepa"                                                                                                                                               
 [9402] "Fluorouracil_Methotrexate_Prednisone_Thiotepa_Vinblastine"                                                                                                            
 [9403] "Doxorubicin_Mercaptopurine_Prednisone_Vincristine"                                                                                                                    
 [9404] "Dacarbazine_Piritrexim"                                                                                                                                               
 [9405] "Doxorubicin_Fluorouracil_Methotrexate_Prednisone_Thiotepa_Vinblastine"                                                                                                
 [9406] "Amiodarone_Doxorubicin_Etoposide"                                                                                                                                     
 [9407] "Amiodarone_Doxorubicin"                                                                                                                                               
 [9408] "Cytarabine_Methotrexate_Vincristine"                                                                                                                                  
 [9409] "Mitomycin_Vinblastine"                                                                                                                                                
 [9410] "Chlorambucil_Fludarabine"                                                                                                                                             
 [9411] "Cyclophosphamide_Doxorubicin_Lomustine"                                                                                                                               
 [9412] "Cisplatin_Dacarbazine_Interleukin-2"                                                                                                                                  
 [9413] "Fluorouracil_Leucovorin-Calcium_Semustine"                                                                                                                            
 [9414] "Fluorouracil_Levamisole"                                                                                                                                              
 [9415] "Cyclophosphamide_Doxorubicin_Fluorouracil_Methotrexate_Sargramostim_Vincristine"                                                                                      
 [9416] "Carboplatin_Cyclophosphamide_Sargramostim"                                                                                                                            
 [9417] "Lomustine_Prednisone_Vincristine"                                                                                                                                     
 [9418] "Carboplatin_Etoposide_Sargramostim"                                                                                                                                   
 [9419] "Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide_Sargramostim"                                                                                                        
 [9420] "Cyclophosphamide_Doxorubicin_Etoposide_Sargramostim"                                                                                                                  
 [9421] "Dacarbazine_Doxorubicin_Ifosfamide_Sargramostim"                                                                                                                      
 [9422] "Prednisone_Sargramostim_Vincristine"                                                                                                                                  
 [9423] "Cisplatin_Cyclophosphamide_Etoposide_Interleukin-2"                                                                                                                   
 [9424] "Melphalan_Sargramostim"                                                                                                                                               
 [9425] "Doxorubicin_Ifosfamide_Lomustine"                                                                                                                                     
 [9426] "Fludarabine_Hydroxyurea"                                                                                                                                              
 [9427] "Azacytidine_Cyclophosphamide_Cytarabine_Thioguanine_Vincristine"                                                                                                      
 [9428] "Cyclophosphamide_Etoposide_Teniposide"                                                                                                                                
 [9429] "Daunorubicin_Etoposide_Prednisone_Teniposide_Thioguanine_Vincristine"                                                                                                 
 [9430] "Cyclophosphamide_Daunorubicin_Etoposide_Prednisone_Teniposide_Thioguanine_Vincristine"                                                                                
 [9431] "Cyclophosphamide_Semustine_Vincristine"                                                                                                                               
 [9432] "Cyclophosphamide_Fluorouracil_Fluoxymesterone_Methotrexate_Prednisone_Tamoxifen"                                                                                      
 [9433] "Cyclophosphamide_Fluoxymesterone_Mitolactol_Prednisone_Tamoxifen"                                                                                                     
 [9434] "Cyclophosphamide_Doxorubicin_Melphalan_Vincristine"                                                                                                                   
 [9435] "Cyclophosphamide_Doxorubicin_Fluorouracil_Methotrexate_Prednisone_Vincristine"                                                                                        
 [9436] "Methotrexate_Teniposide"                                                                                                                                              
 [9437] "Cyclophosphamide_Fluorouracil_Methotrexate_Prednisone_Tamoxifen_Vincristine"                                                                                          
 [9438] "Altretamine_Cyclophosphamide_Doxorubicin_Prednisone_Vincristine"                                                                                                      
 [9439] "Altretamine_Cisplatin_Cyclophosphamide_Misonidazole"                                                                                                                  
 [9440] "Bleomycin_Cytarabine_Methotrexate_Vincristine"                                                                                                                        
 [9441] "Asparaginase_Methotrexate_Vincristine"                                                                                                                                
 [9442] "Prednisolone_Tamoxifen"                                                                                                                                               
 [9443] "Asparaginase_Cyclophosphamide_Methotrexate_Prednisone_Vincristine_Zorubicin"                                                                                          
 [9444] "Cyclophosphamide_Melphalan_Methylprednisolone"                                                                                                                        
 [9445] "Cyclophosphamide_Prednisone_Vincristine_Zorubicin"                                                                                                                    
 [9446] "Doxorubicin_Fluoxymesterone_Mitolactol_Tamoxifen"                                                                                                                     
 [9447] "Fluoxymesterone_Mitolactol_Mitoxantrone_Tamoxifen"                                                                                                                    
 [9448] "Cisplatin_Dianhydrogalactitol_Doxorubicin"                                                                                                                            
 [9449] "Ancitabine-Hydrochloride_Daunorubicin_Mercaptopurine_Prednisolone"                                                                                                    
 [9450] "Doxorubicin_Fluoxymesterone_Methotrexate_Mitolactol_Tamoxifen_Vincristine"                                                                                            
 [9451] "Dianhydrogalactitol_Etoposide"                                                                                                                                        
 [9452] "Azacytidine_Cytarabine_Daunorubicin_Prednisone_Vincristine"                                                                                                           
 [9453] "Fluorouracil_Methotrexate_Mitolactol_Prednisone"                                                                                                                      
 [9454] "BCG_Cyclophosphamide_Doxorubicin_Tegafur"                                                                                                                             
 [9455] "Fluorouracil_Razoxane_Semustine"                                                                                                                                      
 [9456] "Doxorubicin_Mitomycin_Tegafur"                                                                                                                                        
 [9457] "Asparaginase_Methotrexate"                                                                                                                                            
 [9458] "Asparaginase_Cytarabine_Doxorubicin_Prednisone_Vincristine"                                                                                                           
 [9459] "Chlorambucil_Prednisone_Vinblastine_Vincristine"                                                                                                                      
 [9460] "Fluorouracil_Mitomycin"                                                                                                                                               
 [9461] "Carmustine_Cyclophosphamide_Melphalan_Prednisone"                                                                                                                     
 [9462] "Doxorubicin_Lomustine_Mechlorethamine"                                                                                                                                
 [9463] "Doxorubicin_Semustine"                                                                                                                                                
 [9464] "Dactinomycin_Doxorubicin_Methotrexate_Vincristine"                                                                                                                    
 [9465] "Cyclophosphamide_Prednisolone_Teniposide"                                                                                                                             
 [9466] "Fluorouracil_Melphalan"                                                                                                                                               
 [9467] "Doxorubicin_Fluorouracil_Melphalan"                                                                                                                                   
 [9468] "Mercaptopurine_Methotrexate_Vincristine"                                                                                                                              
 [9469] "Cytarabine_Prednisone_Vincristine_Zorubicin"                                                                                                                          
 [9470] "Dacarbazine_Zorubicin"                                                                                                                                                
 [9471] "Methotrexate_Prednisone_Thioguanine_Vincristine"                                                                                                                      
 [9472] "Amifostine_Cisplatin_Monoclonal-Antibody-R24"                                                                                                                         
 [9473] "Fluorouracil_Leucovorin-Calcium_Sargramostim"                                                                                                                         
 [9474] "Bleomycin_Cisplatin_Cyclophosphamide_Doxorubicin_Fluorouracil_Vincristine"                                                                                            
 [9475] "Bleomycin_Cyclophosphamide_Cytarabine_Doxorubicin_Etoposide_Methotrexate_Prednisone_Sargramostim_Vincristine"                                                         
 [9476] "Cisplatin_Cyclophosphamide_Fluorouracil_Vincristine"                                                                                                                  
 [9477] "Altretamine_Cyclophosphamide_Methotrexate"                                                                                                                            
 [9478] "Cisplatin_Mitoguazone_Vinblastine"                                                                                                                                    
 [9479] "Ampligen_Interleukin-2"                                                                                                                                               
 [9480] "Cisplatin_Cytarabine_Etoposide_Sargramostim"                                                                                                                          
 [9481] "Cyclophosphamide_Dexrazoxane_Doxorubicin_Vincristine"                                                                                                                 
 [9482] "Carmustine_Cyclophosphamide_Thiotepa_Vincristine"                                                                                                                     
 [9483] "Asparaginase_Idarubicin_Prednisone_Vincristine"                                                                                                                       
 [9484] "Carmustine_Triazinate"                                                                                                                                                
 [9485] "Asparaginase_Cytarabine_Idarubicin"                                                                                                                                   
 [9486] "Cyclophosphamide_Doxorubicin_Fluorouracil_Prednisone"                                                                                                                 
 [9487] "Asparaginase_Cytarabine_Daunorubicin"                                                                                                                                 
 [9488] "Cyclophosphamide_Doxorubicin_Folic-Acid_Methotrexate"                                                                                                                 
 [9489] "Cyclophosphamide_Cytarabine_Daunorubicin_Dexamethasone_Thioguanine_Vincristine"                                                                                       
 [9490] "Fenretinide_Tamoxifen"                                                                                                                                                
 [9491] "Altretamine_Cisplatin_Cyclophosphamide_Fluorouracil"                                                                                                                  
 [9492] "Dactinomycin_Tumor-Necrosis-Factor"                                                                                                                                   
 [9493] "Cisplatin_Doxorubicin_Fluorouracil_Leucovorin-Calcium"                                                                                                                
 [9494] "Altretamine_Lomustine_Methotrexate"                                                                                                                                   
 [9495] "Cyclophosphamide_Doxorubicin_Melphalan_Methotrexate_Vincristine"                                                                                                      
 [9496] "Cyclophosphamide_Doxorubicin_Ethinyl-Estradiol_Fluorouracil_Leucovorin-Calcium"                                                                                       
 [9497] "Cyclophosphamide_Fluorouracil_Leucovorin-Calcium_Mitoxantrone"                                                                                                        
 [9498] "Floxuridine_Leucovorin-Calcium"                                                                                                                                       
 [9499] "Fluorouracil_Interferon-Beta"                                                                                                                                         
 [9500] "Cyclophosphamide_Doxorubicin_Fluorouracil_Streptozocin"                                                                                                               
 [9501] "Octreotide_Tamoxifen"                                                                                                                                                 
 [9502] "Melphalan_Methylprednisolone_Vincristine"                                                                                                                             
 [9503] "Cyclophosphamide_Doxorubicin_Etoposide_Fluorouracil"                                                                                                                  
 [9504] "Cyclophosphamide_Mercaptopurine_Prednisone_Vincristine"                                                                                                               
 [9505] "Cyclophosphamide_Dexrazoxane_Doxorubicin_Fluorouracil"                                                                                                                
 [9506] "Doxorubicin_Fluorouracil_Mitomycin_Triazinate"                                                                                                                        
 [9507] "Asparaginase_Cytarabine_Sargramostim"                                                                                                                                 
 [9508] "Etoposide_Methotrexate"                                                                                                                                               
 [9509] "Doxorubicin_Fluorouracil_Triazinate"                                                                                                                                  
 [9510] "Interferon-Gamma_Levamisole"                                                                                                                                          
 [9511] "Cyclophosphamide_Doxorubicin_Fluorouracil_Sargramostim"                                                                                                               
 [9512] "Bleomycin_Procarbazine_Vinblastine"                                                                                                                                   
 [9513] "Cytarabine_Doxorubicin_Mercaptopurine_Prednisone_Vincristine"                                                                                                         
 [9514] "Altretamine_Etoposide_Procarbazine"                                                                                                                                   
 [9515] "Bleomycin_Cisplatin_Doxorubicin"                                                                                                                                      
 [9516] "Cisplatin_Doxorubicin_Fluorouracil_Vinblastine"                                                                                                                       
 [9517] "Cytarabine_Doxorubicin_Mercaptopurine"                                                                                                                                
 [9518] "Altretamine_Cyclophosphamide_Doxorubicin"                                                                                                                             
 [9519] "Cytarabine_Prednisone_Thioguanine_Vincristine"                                                                                                                        
 [9520] "Dacarbazine_Dactinomycin_Vincristine"                                                                                                                                 
 [9521] "Cytarabine_Zorubicin"                                                                                                                                                 
 [9522] "Cisplatin_Cyclophosphamide_Cytarabine_Hydroxyurea_Lomustine_Methylprednisolone_Procarbazine_Vincristine"                                                              
 [9523] "Doxorubicin_Methotrexate_Vinblastine"                                                                                                                                 
 [9524] "Altretamine_Doxorubicin_Melphalan"                                                                                                                                    
 [9525] "Altretamine_Doxorubicin_Methotrexate"                                                                                                                                 
 [9526] "Bleomycin_Cisplatin_Dacarbazine_Vinblastine"                                                                                                                          
 [9527] "Bleomycin_Prednisone_Vincristine"                                                                                                                                     
 [9528] "Altretamine_Cisplatin"                                                                                                                                                
 [9529] "Altretamine_Doxorubicin_Fluorouracil_Mitomycin"                                                                                                                       
 [9530] "Carmustine_Cisplatin_Cyclophosphamide_Cytarabine_Hydroxyurea_Methylprednisolone_Procarbazine_Vincristine"                                                             
 [9531] "Amsacrine_Decitabine"                                                                                                                                                 
 [9532] "Decitabine_IDarubicin"                                                                                                                                                
 [9533] "Cyclophosphamide_Fluorouracil_Methotrexate_Tamoxifen"                                                                                                                 
 [9534] "Lomustine_Methotrexate_Vincristine"                                                                                                                                   
 [9535] "Asparaginase_Cyclophosphamide_Daunorubicin_Methotrexate_Prednisone_Vincristine"                                                                                       
 [9536] "Bleomycin_Cisplatin_Mitoguazone_Vindesine"                                                                                                                            
 [9537] "Cisplatin_Cyclophosphamide_Vincristine"                                                                                                                               
 [9538] "Cisplatin_Dacarbazine_Etoposide"                                                                                                                                      
 [9539] "Cytarabine_Etoposide_Prednisone_Teniposide"                                                                                                                           
 [9540] "Asparaginase_Cyclophosphamide_Doxorubicin_Methotrexate_Prednisone_Vincristine"                                                                                        
 [9541] "Methotrexate_Prednisone_Procarbazine_Vincristine"                                                                                                                     
 [9542] "Doxorubicin_Prednisone_Teniposide"                                                                                                                                    
 [9543] "Cytarabine_Daunorubicin_Prednisone_Thioguanine"                                                                                                                       
 [9544] "Melphalan_Prednisone_Vincristine"                                                                                                                                     
 [9545] "Biostim_Melphalan_Prednisone_Vincristine"                                                                                                                             
 [9546] "Conjugated-Estrogens_Cyclophosphamide_Doxorubicin_Fluorouracil_Methotrexate_Tamoxifen"                                                                                
 [9547] "Biostim_Doxorubicin_Etoposide_Prednisone"                                                                                                                             
 [9548] "Doxorubicin_Fluorouracil_Methotrexate_Mitomycin"                                                                                                                      
 [9549] "Daunorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                                                      
 [9550] "Mitolactol_Mitoxantrone_Vincristine"                                                                                                                                  
 [9551] "Doxorubicin_Thiotepa_Vinblastine"                                                                                                                                     
 [9552] "Cytarabine_Melphalan"                                                                                                                                                 
 [9553] "Buthionine-Sulfoximine_Melphalan"                                                                                                                                     
 [9554] "Cyclophosphamide_Cytarabine_Etoposide_Methotrexate_Prednisone_Vincristine"                                                                                            
 [9555] "Lomustine_Mitolactol_Procarbazine_Thioguanine_Vincristine"                                                                                                            
 [9556] "Cisplatin_Cyclophosphamide_Doxorubicin_Misonidazole"                                                                                                                  
 [9557] "Bleomycin_Cyclophosphamide_Cytarabine_Doxorubicin_Methotrexate_Prednisone_Vincristine"                                                                                
 [9558] "Cytarabine_Dexamethasone_Methotrexate"                                                                                                                                
 [9559] "Fluorouracil_Prednisone_Vincristine"                                                                                                                                  
 [9560] "Cisplatin_Fluorouracil_Mitomycin_Vincristine"                                                                                                                         
 [9561] "Doxorubicin_Fluorouracil_Melphalan_Tamoxifen"                                                                                                                         
 [9562] "Fluorouracil_Methotrexate_Vinblastine"                                                                                                                                
 [9563] "Cisplatin_Hydrazine-Sulfate_Vinblastine"                                                                                                                              
 [9564] "Cyclophosphamide_Dexamethasone_Doxorubicin_Verapamil_Vincristine"                                                                                                     
 [9565] "Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide_Fluorouracil_Methotrexate_Vincristine"                                                                               
 [9566] "Busulfan_Melphalan"                                                                                                                                                   
 [9567] "Mechlorethamine_Methotrexate_Prednisone_Procarbazine_Vincristine"                                                                                                     
 [9568] "Cytarabine_Filgrastim"                                                                                                                                                
 [9569] "Cisplatin_Etoposide_Mitoxantrone_Tamoxifen"                                                                                                                           
 [9570] "Etanidazole_Melphalan_Prednisone"                                                                                                                                     
 [9571] "Bleomycin_Cyclophosphamide_Doxorubicin_Methotrexate_Prednisone_Vincristine"                                                                                           
 [9572] "Cisplatin_Doxorubicin_Melphalan_Teniposide"                                                                                                                           
 [9573] "Cytarabine_Daunorubicin_Etoposide_Thioguanine"                                                                                                                        
 [9574] "Cisplatin_Etoposide_Interleukin-2"                                                                                                                                    
 [9575] "Asparaginase_Cyclophosphamide_Cytarabine_Mercaptopurine_Methotrexate_Vincristine"                                                                                     
 [9576] "Doxorubicin_Etoposide_Prednisone"                                                                                                                                     
 [9577] "Trifluoperazine_Vinblastine"                                                                                                                                          
 [9578] "BCG_Cyclophosphamide_Interleukin-2"                                                                                                                                   
 [9579] "Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide_Methotrexate_Vincristine_Vindesine"                                                                                  
 [9580] "Dipyridamole_Vinblastine"                                                                                                                                             
 [9581] "Bleomycin_Cyclophosphamide_Dexamethasone_Doxorubicin_Procarbazine_Vincristine"                                                                                        
 [9582] "Bleomycin_Cisplatin_Mitomycin_Vindesine"                                                                                                                              
 [9583] "Chlorambucil_Etoposide_Lomustine"                                                                                                                                     
 [9584] "Doxorubicin_Melphalan_Teniposide"                                                                                                                                     
 [9585] "Etoposide_Ifosfamide_Vindesine"                                                                                                                                       
 [9586] "Cyclophosphamide_Doxorubicin_Methotrexate_Vinblastine"                                                                                                                
 [9587] "Hydrocortisone_Suramin"                                                                                                                                               
 [9588] "Cyclophosphamide_Dactinomycin_Doxorubicin_Hydroxyurea_Methotrexate_Vincristine"                                                                                       
 [9589] "Cyclophosphamide_Cytarabine_Doxorubicin_Etoposide_Methotrexate_Prednisone_Vincristine"                                                                                
 [9590] "Altretamine_Carboplatin_Cyclophosphamide_Doxorubicin"                                                                                                                 
 [9591] "Cisplatin_Fluorouracil_Vinblastine"                                                                                                                                   
 [9592] "Cyclophosphamide_Dacarbazine_Dactinomycin_Doxorubicin_Vincristine"                                                                                                    
 [9593] "Doxorubicin_Fluorouracil_Vinblastine"                                                                                                                                 
 [9594] "Cyclophosphamide_Cytarabine_Prednisolone_Vincristine"                                                                                                                 
 [9595] "Cisplatin_Dexamethasone_Etoposide"                                                                                                                                    
 [9596] "Cyclophosphamide_Prednisone"                                                                                                                                          
 [9597] "Bleomycin_Cisplatin_Doxorubicin_Etoposide"                                                                                                                            
 [9598] "Doxorubicin_Floxuridine_Mitomycin"                                                                                                                                    
 [9599] "Medroxyprogesterone_Mitomycin_Vinblastine"                                                                                                                            
 [9600] "Procarbazine_Semustine_Vincristine"                                                                                                                                   
 [9601] "Doxorubicin_Mitomycin_Vindesine"                                                                                                                                      
 [9602] "Cisplatin_Cyclophosphamide_Doxorubicin_Vindesine"                                                                                                                     
 [9603] "Mercaptopurine_Methotrexate_Prednisolone_Vincristine"                                                                                                                 
 [9604] "Bleomycin_Cyclophosphamide_Methotrexate_Vincristine"                                                                                                                  
 [9605] "Cisplatin_Fluorouracil"                                                                                                                                               
 [9606] "Bleomycin_Cyclophosphamide_Cytarabine_Prednisone_Vincristine"                                                                                                         
 [9607] "Amsacrine_Cyclophosphamide_Hydroxyurea"                                                                                                                               
 [9608] "Carmustine_Cyclophosphamide_Dexamethasone"                                                                                                                            
 [9609] "Bleomycin_Fluorouracil_Methotrexate_Vincristine"                                                                                                                      
 [9610] "Doxorubicin_Methotrexate_Vincristine"                                                                                                                                 
 [9611] "Cyclophosphamide_Doxorubicin_Vinblastine"                                                                                                                             
 [9612] "Cyclophosphamide_Dactinomycin_Vinblastine"                                                                                                                            
 [9613] "Carmustine_Mercaptopurine"                                                                                                                                            
 [9614] "Doxorubicin_Etoposide_Mitomycin"                                                                                                                                      
 [9615] "Etoposide_Ifosfamide"                                                                                                                                                 
 [9616] "Chlorambucil_Prednisone_Procarbazine_Vinblastine"                                                                                                                     
 [9617] "Cyclophosphamide_Lomustine_Prednisone_Procarbazine_Vincristine"                                                                                                       
 [9618] "Mercaptopurine_Methotrexate_Methylprednisolone_Vincristine"                                                                                                           
 [9619] "Aminoglutethimide_Danazol_Hydrocortisone_Tamoxifen"                                                                                                                   
 [9620] "Aminoglutethimide_Danazol_Medroxyprogesterone_Tamoxifen"                                                                                                              
 [9621] "Bleomycin_Doxorubicin_Vincristine"                                                                                                                                    
 [9622] "Methotrexate_Vinblastine"                                                                                                                                             
 [9623] "Cyclophosphamide_Lomustine_Melphalan_Prednisolone_Vincristine"                                                                                                        
 [9624] "Carboplatin_Vincristine"                                                                                                                                              
 [9625] "Carboplatin_Ifosfamide"                                                                                                                                               
 [9626] "Cyclophosphamide_Etoposide_Methotrexate_Prednisone_Vincristine"                                                                                                       
 [9627] "Bleomycin_Mitomycin_Vindesine"                                                                                                                                        
 [9628] "Dacarbazine_Doxorubicin_Ifosfamide"                                                                                                                                   
 [9629] "Cyclophosphamide_Doxorubicin_Etoposide_Interleukin-2"                                                                                                                 
 [9630] "Floxuridine_Fluorouracil_Leucovorin-Calcium"                                                                                                                          
 [9631] "Epirubicin_Prednisone_Vincristine"                                                                                                                                    
 [9632] "Carmustine_Cyclophosphamide_Doxorubicin_Melphalan_Prednisone_Vincristine"                                                                                             
 [9633] "Bleomycin_Idoxuridine"                                                                                                                                                
 [9634] "Cytarabine_Hydrocortisone_Methotrexate"                                                                                                                               
 [9635] "Etoposide_Tumor-Necrosis-Factor"                                                                                                                                      
 [9636] "Doxorubicin_Fluorouracil_Leucovorin-Calcium_Mitomycin"                                                                                                                
 [9637] "Asparaginase_Doxorubicin_Methotrexate_Prednisone_Vincristine"                                                                                                         
 [9638] "Doxorubicin_Fluorouracil_Methotrexate_Sargramostim"                                                                                                                   
 [9639] "Carboplatin_Cyclophosphamide_Sargramostim_Thiotepa"                                                                                                                   
 [9640] "Asparaginase_Cytarabine_Methotrexate_Vincristine"                                                                                                                     
 [9641] "Thiotepa_Vinblastine"                                                                                                                                                 
 [9642] "Amifostine_Cisplatin_Interleukin-2"                                                                                                                                   
 [9643] "Amifostine_Thiotepa"                                                                                                                                                  
 [9644] "Cyclophosphamide_Mitoxantrone_Prednisone_Vincristine"                                                                                                                 
 [9645] "Cyclophosphamide_Doxorubicin_Fluorouracil_Fluoxymesterone_Thiotepa_Vinblastine"                                                                                       
 [9646] "Asparaginase_Cyclophosphamide_Cytarabine_Methotrexate_Vincristine"                                                                                                    
 [9647] "Cyclophosphamide_Fluorouracil_Fluoxymesterone_Methotrexate"                                                                                                           
 [9648] "Cyclophosphamide_Doxorubicin_Prednisone_Teniposide_Vincristine"                                                                                                       
 [9649] "Doxorubicin_Etoposide_Prednisone_Vincristine"                                                                                                                         
 [9650] "Bleomycin_Carmustine_Etoposide_Methotrexate_Prednisone"                                                                                                               
 [9651] "Carmustine_Cyclophosphamide_Thiotepa"                                                                                                                                 
 [9652] "Bleomycin_Vincristine"                                                                                                                                                
 [9653] "Bleomycin_Vinblastine"                                                                                                                                                
 [9654] "Dactinomycin_Etoposide_Ifosfamide_Vincristine"                                                                                                                        
 [9655] "Cyclophosphamide_Fluorouracil_Fluoxymesterone_Methotrexate_Tamoxifen"                                                                                                 
 [9656] "Cyclophosphamide_Doxorubicin_Fluorouracil_Leucovorin-Calcium"                                                                                                         
 [9657] "Cisplatin_Melphalan_Teniposide"                                                                                                                                       
 [9658] "Asparaginase_Doxorubicin_Vincristine"                                                                                                                                 
 [9659] "Caffeine_Cisplatin_Cytarabine"                                                                                                                                        
 [9660] "Cyclophosphamide_Doxorubicin_Fluorouracil_Leucovorin-Calcium_Sargramostim"                                                                                            
 [9661] "Cisplatin_Paclitaxel"                                                                                                                                                 
 [9662] "Cyclophosphamide_Fluorouracil_Tamoxifen"                                                                                                                              
 [9663] "Cytarabine_Etoposide_Methylprednisolone"                                                                                                                              
 [9664] "Etoposide_Mitoguazone_Mitoxantrone_Vinblastine"                                                                                                                       
 [9665] "Fluorouracil_Interleukin-1-Beta"                                                                                                                                      
 [9666] "Amifostine_Carboplatin"                                                                                                                                               
 [9667] "Bleomycin_Cisplatin_Cyclophosphamide_Dactinomycin_Vinblastine"                                                                                                        
 [9668] "Cisplatin_Fluorouracil_Interleukin-2"                                                                                                                                 
 [9669] "Cisplatin_Mitoxantrone"                                                                                                                                               
 [9670] "Cyclophosphamide_Interleukin-2"                                                                                                                                       
 [9671] "Cytarabine_Daunorubicin_Dexamethasone_Etoposide_Thioguanine"                                                                                                          
 [9672] "Cytarabine_Etoposide"                                                                                                                                                 
 [9673] "Cytarabine_Mitoxantrone_Thioguanine"                                                                                                                                  
 [9674] "Cytarabine_Mitoxantrone_Thioguanine_Vincristine"                                                                                                                      
 [9675] "Etoposide_Mitomycin"                                                                                                                                                  
 [9676] "Fluorouracil_PALA"                                                                                                                                                    
 [9677] "Ifosfamide_Mitoxantrone"                                                                                                                                              
 [9678] "Interferon-Gamma_Tumor-Necrosis-Factor"                                                                                                                               
 [9679] "Interleukin-2_Lymphokine-Activated-Killer-Cells"                                                                                                                      
 [9680] "Asparaginase_Cytarabine_Prednisone_Vincristine"                                                                                                                       
 [9681] "Asparaginase_Cyclophosphamide_Cytarabine"                                                                                                                             
 [9682] "Fluorouracil_Methotrexate_PALA"                                                                                                                                       
 [9683] "Carboplatin_Vinblastine"                                                                                                                                              
 [9684] "Cisplatin_Mitomycin_Triazinate"                                                                                                                                       
 [9685] "Cyclophosphamide_Cytarabine"                                                                                                                                          
 [9686] "Cytarabine_Teniposide"                                                                                                                                                
 [9687] "Etoposide_Mitoxantrone_Thiotepa"                                                                                                                                      
 [9688] "Fluorouracil_Semustine"                                                                                                                                               
 [9689] "Mercaptopurine_Methotrexate"                                                                                                                                          
 [9690] "Mercaptopurine_Prednisone_Vincristine"                                                                                                                                
 [9691] "Fludarabine_Prednisone"                                                                                                                                               
 [9692] "Cyclophosphamide_Diethylstilbestrol_Fluorouracil_Methotrexate"                                                                                                        
 [9693] "Cisplatin_Etoposide_Mitoguazone"                                                                                                                                      
 [9694] "Cisplatin_Mitomycin_Vinblastine"                                                                                                                                      
 [9695] "Cisplatin_Mitomycin_Vindesine"                                                                                                                                        
 [9696] "Cisplatin_Vinblastine"                                                                                                                                                
 [9697] "Cisplatin_Vindesine"                                                                                                                                                  
 [9698] "Cisplatin_Cyclophosphamide_Doxorubicin"                                                                                                                               
 [9699] "Cyclophosphamide_Doxorubicin_Lomustine_Prednisone_Vincristine"                                                                                                        
 [9700] "Bleomycin_Dacarbazine_Doxorubicin_Mechlorethamine_Prednisone_Procarbazine_Vinblastine_Vincristine"                                                                    
 [9701] "Cisplatin_Cyclophosphamide_Etoposide"                                                                                                                                 
 [9702] "Cisplatin_Cyclophosphamide_Etoposide_Lomustine_Vincristine"                                                                                                           
 [9703] "Cyclophosphamide_Cytarabine_Prednisone_Thioguanine_Vincristine"                                                                                                       
 [9704] "Cytarabine_Daunorubicin"                                                                                                                                              
 [9705] "Cytarabine_Doxorubicin_Etoposide_Thioguanine"                                                                                                                         
 [9706] "Cytarabine_Etoposide_Methotrexate"                                                                                                                                    
 [9707] "Doxorubicin_Fluorouracil"                                                                                                                                             
 [9708] "Cyclophosphamide_Doxorubicin_Etoposide_Lomustine_Vincristine"                                                                                                         
 [9709] "Cytarabine_Methotrexate"                                                                                                                                              
 [9710] "Cytarabine_Thioguanine"                                                                                                                                               
 [9711] "Doxorubicin_Etoposide_Methotrexate"                                                                                                                                   
 [9712] "Doxorubicin_Fluorouracil_Mitomycin_Vincristine"                                                                                                                       
 [9713] "Doxorubicin_Fluorouracil_Semustine"                                                                                                                                   
 [9714] "Doxorubicin_Vincristine"                                                                                                                                              
 [9715] "Altretamine_Etoposide_Methotrexate"                                                                                                                                   
 [9716] "Fluorouracil_Methotrexate"                                                                                                                                            
 [9717] "Altretamine_Cisplatin_Cyclophosphamide"                                                                                                                               
 [9718] "Cisplatin_Methotrexate"                                                                                                                                               
 [9719] "Cisplatin_Ifosfamide"                                                                                                                                                 
 [9720] "Altretamine_Doxorubicin_Fluoxymesterone_Methotrexate_Mitolactol_Prednisone_Tamoxifen_Vincristine"                                                                     
 [9721] "Altretamine_Cyclophosphamide_Doxorubicin_Fluorouracil_Fluoxymesterone_Methotrexate_Prednisone_Tamoxifen_Vinblastine"                                                  
 [9722] "Carboplatin_Etoposide"                                                                                                                                                
 [9723] "Carboplatin_Fluorouracil_Methotrexate"                                                                                                                                
 [9724] "Asparaginase_Cytarabine_Daunorubicin_Prednisone_Teniposide_Vincristine"                                                                                               
 [9725] "Cisplatin_Ifosfamide_Vinblastine"                                                                                                                                     
 [9726] "Etoposide_Thiotepa"                                                                                                                                                   
 [9727] "Amphotericin-B_Flucytosine"                                                                                                                                           
 [9728] "Doxorubicin_Ethiodized-Oil"                                                                                                                                           
 [9729] "Cisplatin_Doxorubicin_Etoposide_Fluorouracil_Mitomycin"                                                                                                               
 [9730] "Mechlorethamine_Prednisone_Procarbazine_Sargramostim_Vincristine"                                                                                                     
 [9731] "Asparaginase_Daunorubicin_Prednisolone_Vincristine"                                                                                                                   
 [9732] "Asparaginase_Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Vincristine"                                                                                       
 [9733] "Asparaginase_Cyclophosphamide_Cytarabine_Mercaptopurine_Methotrexate"                                                                                                 
 [9734] "Asparaginase_Cytarabine_Mercaptopurine_Methotrexate_Prednisolone_Teniposide_Vincristine"                                                                              
 [9735] "Daunorubicin_Dexamethasone_Ifosfamide_Methotrexate_Thioguanine_Vindesine"                                                                                             
 [9736] "Carmustine_Cisplatin_Dacarbazine"                                                                                                                                     
 [9737] "Cisplatin_Tamoxifen"                                                                                                                                                  
 [9738] "Eflornithine_Mitoguazone"                                                                                                                                             
 [9739] "Asparaginase_Cytarabine_Mercaptopurine_Methotrexate_Prednisone_Teniposide"                                                                                            
 [9740] "Amiodarone_Vinblastine"                                                                                                                                               
 [9741] "Doxorubicin_Quinidine"                                                                                                                                                
 [9742] "Quinidine_Vinblastine"                                                                                                                                                
 [9743] "BCG_Fluorouracil"                                                                                                                                                     
 [9744] "Bropirimine_Tamoxifen"                                                                                                                                                
 [9745] "Acyclovir_Zidovudine"                                                                                                                                                 
 [9746] "Cyclophosphamide_Vincristine"                                                                                                                                         
 [9747] "Dactinomycin_Vincristine"                                                                                                                                             
 [9748] "Dactinomycin_Doxorubicin_Vincristine"                                                                                                                                 
 [9749] "Amifostine_Cisplatin"                                                                                                                                                 
 [9750] "Lomustine_Mitoxantrone_Vinblastine"                                                                                                                                   
 [9751] "Dexamethasone_Metoclopramide_Midazolam"                                                                                                                               
 [9752] "Cisplatin_Cyclophosphamide_10-EdAM"                                                                                                                                   
 [9753] "Bleomycin_Cyclophosphamide_Dexamethasone_Doxorubicin_Methotrexate_Sargramostim_Vincristine"                                                                           
 [9754] "Cyclophosphamide_Doxorubicin_Sargramostim"                                                                                                                            
 [9755] "Carmustine_Cyclophosphamide_Etoposide_Filgrastim"                                                                                                                     
 [9756] "Cyclophosphamide_Doxorubicin_Etoposide_Filgrastim"                                                                                                                    
 [9757] "Methotrexate_Vincristine"                                                                                                                                             
 [9758] "Cisplatin_Vincristine"                                                                                                                                                
 [9759] "Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide_Methotrexate_Vincristine"                                                                                            
 [9760] "Carmustine_Cyclophosphamide_Melphalan_Misonidazole_Prednisone"                                                                                                        
 [9761] "Cytarabine_Hydroxyurea"                                                                                                                                               
 [9762] "Fluorouracil_Hydroxyurea"                                                                                                                                             
 [9763] "Melphalan_Misonidazole"                                                                                                                                               
 [9764] "Cyclophosphamide_Interleukin-2_Tumor-Infiltrating-Lymphocytes"                                                                                                        
 [9765] "Doxorubicin_Fluorouracil_Thiotepa"                                                                                                                                    
 [9766] "Cyclophosphamide_Doxorubicin_Fluorouracil_Tamoxifen"                                                                                                                  
 [9767] "Mitoxantrone_Thiotepa"                                                                                                                                                
 [9768] "Cyclophosphamide_Daunorubicin_Methotrexate_Prednisone_Vincristine"                                                                                                    
 [9769] "Cyclophosphamide_Thioguanine"                                                                                                                                         
 [9770] "Daunorubicin_Hydroxyurea"                                                                                                                                             
 [9771] "Carmustine_Methotrexate"                                                                                                                                              
 [9772] "Cytarabine_Vincristine"                                                                                                                                               
 [9773] "Etoposide_Ifosfamide_Mitoxantrone"                                                                                                                                    
 [9774] "Thiotepa_Vincristine"                                                                                                                                                 
 [9775] "Cisplatin_Cyclophosphamide_Etoposide_Thiotepa_Vincristine"                                                                                                            
 [9776] "Fluorouracil_Leucovorin-Calcium_PALA"                                                                                                                                 
 [9777] "Lomustine_Mitolactol_Procarbazine_Thioguanine"                                                                                                                        
 [9778] "Carboplatin_Etoposide_Ifosfamide"                                                                                                                                     
 [9779] "Dexamethasone_Doxorubicin_Verapamil_Vincristine"                                                                                                                      
 [9780] "Doxorubicin_Fluorouracil_Tamoxifen_Thiotepa"                                                                                                                          
 [9781] "Fluorouracil_Methotrexate_Tamoxifen_Thiotepa"                                                                                                                         
 [9782] "Cisplatin_Etoposide_Sargramostim"                                                                                                                                     
 [9783] "Cisplatin_Doxorubicin_Etoposide_Ifosfamide"                                                                                                                           
 [9784] "Cyclophosphamide_Interleukin-2_Lymphokine-Activated-Killer-Cells"                                                                                                     
 [9785] "Edatrexate_Mitomycin_Vinblastine"                                                                                                                                     
 [9786] "Cyclophosphamide_Doxorubicin_Fluorouracil_Goserelin_Tamoxifen"                                                                                                        
 [9787] "Cyclophosphamide_Doxorubicin_Fluorouracil_Goserelin"                                                                                                                  
 [9788] "Carmustine_Tiazofurin"                                                                                                                                                
 [9789] "Cisplatin_Fluorouracil_Leucovorin-Calcium_Mitomycin"                                                                                                                  
 [9790] "Asparaginase_Cyclophosphamide_Cytarabine_Thioguanine_Vincristine"                                                                                                     
 [9791] "Interferon-Gamma_Sargramostim"                                                                                                                                        
 [9792] "Cytarabine_Daunorubicin_Etoposide_Prednisolone_Thioguanine_Vincristine"                                                                                               
 [9793] "Cyclophosphamide_Doxorubicin_Etoposide_Filgrastim_Prednisone_Vincristine"                                                                                             
 [9794] "Carboplatin_Cisplatin_Etoposide"                                                                                                                                      
 [9795] "Asparaginase_Cyclophosphamide_Cytarabine_Idarubicin_Methotrexate_Prednisone_Vincristine"                                                                              
 [9796] "Dactinomycin_Idarubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                                           
 [9797] "Carmustine_Cyclophosphamide_Dactinomycin_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                          
 [9798] "Carboplatin_Cyclophosphamide_Mitoxantrone"                                                                                                                            
 [9799] "Fluorouracil_Leucovorin-Calcium_Thiotepa"                                                                                                                             
 [9800] "Interleukin-2_Lymphokine-Activated-Killer-Cells_Monoclonal-Antibody-R24"                                                                                              
 [9801] "Cyclophosphamide_Etoposide_Thiotepa"                                                                                                                                  
 [9802] "Dacarbazine_Interleukin-2"                                                                                                                                            
 [9803] "Cisplatin_Dacarbazine_Tamoxifen"                                                                                                                                      
 [9804] "Busulfan_Mitoxantrone"                                                                                                                                                
 [9805] "Cyclophosphamide_Interleukin-2_Monoclonal-Antibody-R24"                                                                                                               
 [9806] "Chlorambucil_Etoposide_Prednisone_Vincristine"                                                                                                                        
 [9807] "Cytarabine_Etoposide_Prednisone"                                                                                                                                      
 [9808] "Busulfan_Cytarabine_Etoposide"                                                                                                                                        
 [9809] "Doxorubicin_Prochlorperazine"                                                                                                                                         
 [9810] "Cytarabine_Fludarabine"                                                                                                                                               
 [9811] "Doxorubicin_Sargramostim"                                                                                                                                             
 [9812] "Carboplatin_Cisplatin_Ifosfamide"                                                                                                                                     
 [9813] "Carboplatin_Doxorubicin_Etoposide_Vincristine"                                                                                                                        
 [9814] "Mechlorethamine_Vincristine"                                                                                                                                          
 [9815] "Carboplatin_Etoposide_Mechlorethamine_Vincristine"                                                                                                                    
 [9816] "Cisplatin_Ifosfamide_Sargramostim_Vinblastine"                                                                                                                        
 [9817] "Cisplatin_Etoposide_Ifosfamide_Sargramostim"                                                                                                                          
 [9818] "Cytarabine_Daunorubicin_Sargramostim"                                                                                                                                 
 [9819] "Ethacrynic-Acid_Melphalan"                                                                                                                                            
 [9820] "Cyclophosphamide_Diethylstilbestrol_Fluorouracil"                                                                                                                     
 [9821] "BCG_Mitomycin"                                                                                                                                                        
 [9822] "Carboplatin_Etoposide_Interleukin-1-Beta"                                                                                                                             
 [9823] "Dipyridamole_Fluorouracil_Leucovorin-Calcium_Zidovudine"                                                                                                              
 [9824] "Cyclophosphamide_Doxorubicin_Etoposide_Methotrexate_Sargramostim_Vincristine"                                                                                         
 [9825] "Cyclophosphamide_Doxorubicin_Etoposide_Methotrexate_Pentamidine_Sargramostim_Vincristine_Zidovudine"                                                                  
 [9826] "Eflornithine_Lomustine_Procarbazine_Vincristine"                                                                                                                      
 [9827] "Carboplatin_Doxorubicin"                                                                                                                                              
 [9828] "Carboplatin_Doxorubicin_Sargramostim"                                                                                                                                 
 [9829] "Cisplatin_Lomustine_Vincristine"                                                                                                                                      
 [9830] "Daunorubicin_Dexamethasone_Vincristine"                                                                                                                               
 [9831] "Cyclophosphamide_Etoposide_Mercaptopurine_Methotrexate"                                                                                                               
 [9832] "Asparaginase_Dexamethasone_Vincristine"                                                                                                                               
 [9833] "Cyclophosphamide_Mercaptopurine_Methotrexate_Vincristine"                                                                                                             
 [9834] "Flutamide_Leuprolide"                                                                                                                                                 
 [9835] "Cisplatin_Etoposide_Hydrazine-Sulfate"                                                                                                                                
 [9836] "Fluorouracil_L-Leucovorin"                                                                                                                                            
 [9837] "Carboplatin_Cytarabine_Etoposide_Methylprednisolone"                                                                                                                  
 [9838] "Carboplatin_Mitoxantrone"                                                                                                                                             
 [9839] "Carboplatin_Etoposide_Melphalan"                                                                                                                                      
 [9840] "Carmustine_Vincristine"                                                                                                                                               
 [9841] "Carmustine_Nimodipine_Vincristine"                                                                                                                                    
 [9842] "Floxuridine_Fluorouracil"                                                                                                                                             
 [9843] "Cisplatin_Cyclophosphamide_Interleukin-2"                                                                                                                             
 [9844] "Cisplatin_Cytarabine_Fluorouracil"                                                                                                                                    
 [9845] "Cisplatin_Cytarabine_Fluorouracil_Sargramostim"                                                                                                                       
 [9846] "Asparaginase_Cyclophosphamide_Cytarabine_Methotrexate"                                                                                                                
 [9847] "Dactinomycin_Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                                          
 [9848] "Nimodipine_Vincristine"                                                                                                                                               
 [9849] "Cytarabine_Methylprednisolone_Mitoxantrone_Vincristine"                                                                                                               
 [9850] "Carboplatin_Cytarabine_Etoposide"                                                                                                                                     
 [9851] "Fluorouracil_Hydroxyurea_Idoxuridine"                                                                                                                                 
 [9852] "Carboplatin_Cisplatin_Doxorubicin_Methotrexate_Vinblastine"                                                                                                           
 [9853] "Cisplatin_Cyclosporine"                                                                                                                                               
 [9854] "Acivicin_Aminosyn"                                                                                                                                                    
 [9855] "Carboplatin_Doxorubicin_Methotrexate_Vinblastine"                                                                                                                     
 [9856] "Carmustine_Etoposide_Thiotepa"                                                                                                                                        
 [9857] "Etoposide_Idarubicin_Methotrexate"                                                                                                                                    
 [9858] "Cisplatin_Etoposide_Thiotepa"                                                                                                                                         
 [9859] "Cisplatin_Doxorubicin_Etoposide_Sargramostim"                                                                                                                         
 [9860] "Cisplatin_Etoposide_Megestrol"                                                                                                                                        
 [9861] "BCG_Interleukin-2"                                                                                                                                                    
 [9862] "Cisplatin_Cyclophosphamide_Doxorubicin_Prednisone"                                                                                                                    
 [9863] "Cisplatin_Dihydro-5-Azacytidine"                                                                                                                                      
 [9864] "Interleukin-2_Monoclonal-Antibody-14G2A"                                                                                                                              
 [9865] "Carboplatin_Cyclophosphamide_Etanidazole"                                                                                                                             
 [9866] "Cyclosporine_Interferon-Gamma"                                                                                                                                        
 [9867] "Floxuridine_Fluorouracil_Leucovorin-Calcium_Levamisole"                                                                                                               
 [9868] "Cimetidine_Cyclophosphamide_Indomethacin_Interleukin-2"                                                                                                               
 [9869] "Amifostine_Carboplatin_Cisplatin"                                                                                                                                     
 [9870] "Dipyridamole_Fluorouracil_PALA"                                                                                                                                       
 [9871] "Daunorubicin_Tamoxifen"                                                                                                                                               
 [9872] "Cisplatin_Cytarabine_Dexamethasone_Etoposide_Sargramostim"                                                                                                            
 [9873] "Dexamethasone_Doxorubicin_Quinine_Verapamil_Vincristine"                                                                                                              
 [9874] "Carboplatin_Etoposide_Monoclonal-Antibody-3F8"                                                                                                                        
 [9875] "Cyclophosphamide_Doxorubicin_Etoposide_Prednisolone_Vincristine"                                                                                                      
 [9876] "Cyclophosphamide_Dexverapamil_Doxorubicin_Etoposide_Prednisone_Vincristine"                                                                                           
 [9877] "Cyclophosphamide_Dexverapamil_Doxorubicin_Etoposide_Prednisolone_Vincristine"                                                                                         
 [9878] "Fluorouracil_Idoxuridine_Leucovorin-Calcium"                                                                                                                          
 [9879] "Filgrastim_Paclitaxel"                                                                                                                                                
 [9880] "Amifostine_Mitomycin"                                                                                                                                                 
 [9881] "Cytarabine_Interleukin-3"                                                                                                                                             
 [9882] "Carboplatin_Cisplatin_Etoposide_Sargramostim"                                                                                                                         
 [9883] "Chlorambucil_Epirubicin"                                                                                                                                              
 [9884] "Altretamine_Carboplatin_Cyclophosphamide"                                                                                                                             
 [9885] "Cyclophosphamide_Doxorubicin_Fluorouracil_Methotrexate_Prednisone"                                                                                                    
 [9886] "Cisplatin_Cyclophosphamide_Fluorouracil_Methotrexate_Prednisone"                                                                                                      
 [9887] "Cyclophosphamide_Melphalan"                                                                                                                                           
 [9888] "Bleomycin_Cisplatin_Etoposide_Ifosfamide"                                                                                                                             
 [9889] "Cisplatin_Doxorubicin_Filgrastim_Methotrexate_Vinblastine"                                                                                                            
 [9890] "Cisplatin_Filgrastim_Paclitaxel"                                                                                                                                      
 [9891] "Flutamide_Leuprolide_Suramin"                                                                                                                                         
 [9892] "Fluorouracil_Leucovorin-Calcium_Mitoxantrone_Vincristine"                                                                                                             
 [9893] "Cytarabine_Daunorubicin_Pegaspargase_Prednisone_Vincristine"                                                                                                          
 [9894] "Fluorouracil_Interleukin-2_Leucovorin-Calcium_Lymphokine-Activated-Killer-Cells"                                                                                      
 [9895] "Carboplatin_Interleukin-1-Alpha"                                                                                                                                      
 [9896] "Carboplatin_Etoposide_Ifosfamide_Sargramostim"                                                                                                                        
 [9897] "Cisplatin_Cyclophosphamide_Leuprolide"                                                                                                                                
 [9898] "Interferon-Gamma_Interleukin-2_Tumor-Infiltrating-Lymphocytes"                                                                                                        
 [9899] "Asparaginase_Cytarabine_Methotrexate_Prednisone_Thioguanine"                                                                                                          
 [9900] "Asparaginase_Cytarabine_Methotrexate_Prednisone_Vincristine"                                                                                                          
 [9901] "Asparaginase_Prednisone"                                                                                                                                              
 [9902] "Cyclophosphamide_Cytarabine_Daunorubicin_Methotrexate_Prednisone_Thioguanine_Vincristine"                                                                             
 [9903] "Asparaginase_Cyclophosphamide_Cytarabine_Daunorubicin_Methotrexate_Prednisone_Thioguanine_Vincristine"                                                                
 [9904] "Doxorubicin_Estradiol_Goserelin_Thiotepa_Vinblastine"                                                                                                                 
 [9905] "Fluoxymesterone_Tamoxifen"                                                                                                                                            
 [9906] "Carboplatin_Fluorouracil_Procarbazine"                                                                                                                                
 [9907] "Fluorouracil_Leucovorin-Calcium_Zidovudine"                                                                                                                           
 [9908] "Filgrastim_Piroxantrone"                                                                                                                                              
 [9909] "Doxorubicin_Paclitaxel"                                                                                                                                               
 [9910] "Doxorubicin_Filgrastim_Paclitaxel"                                                                                                                                    
 [9911] "Cyclophosphamide_Daunorubicin_Dexamethasone_Etoposide_Methotrexate_Thiotepa_Vincristine"                                                                              
 [9912] "Asparaginase_Cytarabine_Etoposide_Methotrexate_Methylprednisolone_Vincristine"                                                                                        
 [9913] "Asparaginase_Cytarabine_Etoposide"                                                                                                                                    
 [9914] "Interleukin-2_PEG-Interleukin-2"                                                                                                                                      
 [9915] "Cisplatin_Dacarbazine_Interleukin-2_Tamoxifen"                                                                                                                        
 [9916] "Idoxuridine_Leucovorin-Calcium"                                                                                                                                       
 [9917] "Cyclophosphamide_Dexamethasone_Vincristine"                                                                                                                           
 [9918] "Cyclophosphamide_Dexamethasone_Filgrastim_Vincristine"                                                                                                                
 [9919] "Carmustine_Cisplatin_Cyclophosphamide_Filgrastim"                                                                                                                     
 [9920] "Cyclophosphamide_Doxorubicin_Filgrastim_Prednisone_Vincristine"                                                                                                       
 [9921] "Diaziquone_Sargramostim"                                                                                                                                              
 [9922] "Cyclophosphamide_Fludarabine"                                                                                                                                         
 [9923] "Filgrastim_Fluorouracil_Leucovorin-Calcium"                                                                                                                           
 [9924] "Asparaginase_Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Thioguanine_Vincristine"                                                                           
 [9925] "Carboplatin_Interleukin-3"                                                                                                                                            
 [9926] "Methotrexate_Thioguanine"                                                                                                                                             
 [9927] "Carboplatin_Fluorouracil_Hydroxyurea_Leucovorin-Calcium"                                                                                                              
 [9928] "Cisplatin_Fluorouracil_Hydroxyurea_Leucovorin-Calcium"                                                                                                                
 [9929] "Carboplatin_Doxorubicin_Ifosfamide"                                                                                                                                   
 [9930] "Cyclophosphamide_Doxorubicin_Filgrastim"                                                                                                                              
 [9931] "Doxorubicin_Vinblastine"                                                                                                                                              
 [9932] "Dimethylbusulfan_Etoposide"                                                                                                                                           
 [9933] "Dacarbazine_Tamoxifen"                                                                                                                                                
 [9934] "Amifostine_Cisplatin_Etoposide"                                                                                                                                       
 [9935] "Cyclophosphamide_Etoposide_Sargramostim"                                                                                                                              
 [9936] "Piroxantrone_Sargramostim"                                                                                                                                            
 [9937] "Carboplatin_Epoetin-Alfa_Etoposide"                                                                                                                                   
 [9938] "Carboplatin_Cytarabine_Dexamethasone"                                                                                                                                 
 [9939] "Carboplatin_Cytarabine_Dexamethasone_Sargramostim"                                                                                                                    
 [9940] "Carboplatin_Dacarbazine"                                                                                                                                              
 [9941] "Carboplatin_Dacarbazine_Tamoxifen"                                                                                                                                    
 [9942] "Cyclophosphamide_Dexamethasone_Doxorubicin_Methotrexate_Vincristine"                                                                                                  
 [9943] "Cyclophosphamide_Filgrastim"                                                                                                                                          
 [9944] "Filgrastim_Interleukin-1-Beta"                                                                                                                                        
 [9945] "Cisplatin_Fluorouracil_Hydroxyurea"                                                                                                                                   
 [9946] "Cisplatin_Filgrastim_Fluorouracil_Hydroxyurea"                                                                                                                        
 [9947] "Etoposide_Fluorouracil_Leucovorin-Calcium"                                                                                                                            
 [9948] "Brequinar_Fluorouracil"                                                                                                                                               
 [9949] "Cyclophosphamide_Interleukin-3_Sargramostim"                                                                                                                          
 [9950] "Cyclophosphamide_Detox_Interleukin-2"                                                                                                                                 
 [9951] "Bleomycin_Cisplatin_Etoposide_Filgrastim"                                                                                                                             
 [9952] "Bleomycin_Cisplatin_Filgrastim_Vincristine"                                                                                                                           
 [9953] "Bleomycin_Cisplatin_Etoposide_Filgrastim_Ifosfamide"                                                                                                                  
 [9954] "Chlorambucil_Ethacrynic-Acid"                                                                                                                                         
 [9955] "Cyclosporine_Dexamethasone_Doxorubicin_Vincristine"                                                                                                                   
 [9956] "Interferon-Gamma_Macrophage-Colony-Stimulating-Factor"                                                                                                                
 [9957] "Cyclophosphamide_Doxorubicin_Fluorouracil_Interleukin-3_Leucovorin-Calcium"                                                                                           
 [9958] "Cyclophosphamide_Doxorubicin_Fluorouracil_Interleukin-3_Leucovorin-Calcium_Sargramostim"                                                                              
 [9959] "Doxorubicin_Suramin"                                                                                                                                                  
 [9960] "Pentoxifylline_Suramin_Thiotepa"                                                                                                                                      
 [9961] "Cisplatin_Filgrastim_Methotrexate_Vinblastine"                                                                                                                        
 [9962] "Doxorubicin_Filgrastim_Thiotepa"                                                                                                                                      
 [9963] "Doxorubicin_Thiotepa"                                                                                                                                                 
 [9964] "Cisplatin_Fluorouracil_Mitomycin_Vindesine"                                                                                                                           
 [9965] "Cisplatin_Doxorubicin_Methotrexate_Sargramostim_Vinblastine"                                                                                                          
 [9966] "Melphalan_Vincristine"                                                                                                                                                
 [9967] "Carboplatin_Cisplatin_Cyclophosphamide_Filgrastim"                                                                                                                    
 [9968] "Filgrastim_Topotecan"                                                                                                                                                 
 [9969] "Cyclophosphamide_Dexamethasone_Doxorubicin_Quinine_Verapamil_Vincristine"                                                                                             
 [9970] "Carboplatin_Ifosfamide_Sargramostim"                                                                                                                                  
 [9971] "Epoetin-Alfa_Filgrastim"                                                                                                                                              
 [9972] "Interleukin-2_Levamisole"                                                                                                                                             
 [9973] "Carboplatin_Etoposide_Ifosfamide_Interleukin-1-Alpha"                                                                                                                 
 [9974] "Cisplatin_Cyclophosphamide_Etoposide_Interleukin-2_Sargramostim"                                                                                                      
 [9975] "Etoposide_Metronidazole"                                                                                                                                              
 [9976] "Etoposide_Ketoconazole_Metronidazole"                                                                                                                                 
 [9977] "Dipyridamole_Etoposide_Ketoconazole_Metronidazole"                                                                                                                    
 [9978] "Dipyridamole_Etoposide_Ketoconazole_Metronidazole_Tamoxifen"                                                                                                          
 [9979] "Dipyridamole_Etoposide_Ketoconazole_Metronidazole_Quinidine_Tamoxifen"                                                                                                
 [9980] "Cyclosporine_Dipyridamole_Etoposide_Ketoconazole_Metronidazole_Quinidine_Tamoxifen"                                                                                   
 [9981] "Doxorubicin_Verapamil"                                                                                                                                                
 [9982] "Cisplatin_Etoposide_Filgrastim_Melphalan"                                                                                                                             
 [9983] "Asparaginase_Cyclophosphamide_Daunorubicin_Filgrastim_Prednisone_Vincristine"                                                                                         
 [9984] "Asparaginase_Cyclophosphamide_Cytarabine_Filgrastim_Mercaptopurine_Vincristine"                                                                                       
 [9985] "Altretamine_Cisplatin_Etoposide"                                                                                                                                      
 [9986] "Amifostine_Melphalan"                                                                                                                                                 
 [9987] "Cytarabine_Pegaspargase"                                                                                                                                              
 [9988] "Idarubicin_Tretinoin"                                                                                                                                                 
 [9989] "Idarubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                                                        
 [9990] "Cyclophosphamide_Doxorubicin_Etoposide_Medroxyprogesterone_Quinine"                                                                                                   
 [9991] "Pentostatin_Sargramostim"                                                                                                                                             
 [9992] "Carboplatin_Diethyldithiocarbamate"                                                                                                                                   
 [9993] "Levamisole_Tamoxifen"                                                                                                                                                 
 [9994] "Fluorouracil_Idoxuridine_Leucovorin-Calcium_PALA"                                                                                                                     
 [9995] "Fluorouracil_Leucovorin-Calcium_PALA_Zidovudine"                                                                                                                      
 [9996] "Somatuline_Suramin"                                                                                                                                                   
 [9997] "Flutamide_Leuprolide_Somatuline_Suramin"                                                                                                                              
 [9998] "Interleukin-2_Interleukin-6"                                                                                                                                          
 [9999] "Fluorouracil_Leucovorin-Calcium_Trimetrexate-Glucuronate"                                                                                                             
[10000] "Asparaginase_Cytarabine_Mercaptopurine_Methotrexate_Vincristine"                                                                                                      
[10001] "Asparaginase_Mercaptopurine_Methotrexate_Pegaspargase_Vincristine"                                                                                                    
[10002] "Dexamethasone_Doxorubicin_Methotrexate_Pegaspargase_Vincristine"                                                                                                      
[10003] "Asparaginase_Dexamethasone_Doxorubicin_Mercaptopurine_Methotrexate_Vincristine"                                                                                       
[10004] "Asparaginase_Dexamethasone_Doxorubicin_Methotrexate_Vincristine"                                                                                                      
[10005] "Asparaginase_Dexamethasone_Mercaptopurine_Methotrexate_Vincristine"                                                                                                   
[10006] "Dexamethasone_Doxorubicin_Mercaptopurine_Methotrexate_Pegaspargase_Vincristine"                                                                                       
[10007] "Dexamethasone_Mercaptopurine_Methotrexate_Pegaspargase_Vincristine"                                                                                                   
[10008] "Dexamethasone_Mercaptopurine_Methotrexate_Vincristine"                                                                                                                
[10009] "Asparaginase_Cyclophosphamide_Cytarabine_Filgrastim"                                                                                                                  
[10010] "Asparaginase_Cyclophosphamide_Filgrastim"                                                                                                                             
[10011] "Asparaginase_Filgrastim_Teniposide"                                                                                                                                   
[10012] "Doxorubicin_Filgrastim_Mercaptopurine_Prednisone_Vincristine"                                                                                                         
[10013] "Doxorubicin_Filgrastim_Prednisone_Vincristine"                                                                                                                        
[10014] "Cyclophosphamide_Dactinomycin_Doxorubicin_Filgrastim_Vincristine"                                                                                                     
[10015] "Etoposide_Filgrastim_Melphalan"                                                                                                                                       
[10016] "Cisplatin_Doxorubicin_Etoposide_Filgrastim_Ifosfamide"                                                                                                                
[10017] "Bleomycin_Doxorubicin_Etoposide_Mechlorethamine_Vinblastine_Vincristine"                                                                                              
[10018] "Interleukin-1-Alpha_Interleukin-2"                                                                                                                                    
[10019] "Trifluoperazine_Verapamil"                                                                                                                                            
[10020] "Doxorubicin_Filgrastim"                                                                                                                                               
[10021] "Doxorubicin_Trifluoperazine_Vinblastine_Verapamil"                                                                                                                    
[10022] "Carboplatin_Edatrexate"                                                                                                                                               
[10023] "BCG_Isoniazid"                                                                                                                                                        
[10024] "Cisplatin_Edatrexate"                                                                                                                                                 
[10025] "Hexamethylene-Bisacetamide_Tretinoin"                                                                                                                                 
[10026] "Bromocriptine_Flutamide"                                                                                                                                              
[10027] "Bromocriptine_Flutamide_Leuprolide"                                                                                                                                   
[10028] "Flutamide_Ketoconazole_Leuprolide"                                                                                                                                    
[10029] "Flutamide_Ketoconazole"                                                                                                                                               
[10030] "Trifluoperazine_Verapamil_Vinblastine"                                                                                                                                
[10031] "Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide_Fluorouracil_Vincristine"                                                                                            
[10032] "Busulfan_Etoposide"                                                                                                                                                   
[10033] "Cytarabine_Etoposide_Methotrexate_Prednisone"                                                                                                                         
[10034] "Cisplatin_Ifosfamide_Mitomycin"                                                                                                                                       
[10035] "Carboplatin_Etoposide_Interleukin-3"                                                                                                                                  
[10036] "Interleukin-1-Beta_Interleukin-2"                                                                                                                                     
[10037] "Cisplatin_Cyclophosphamide_Paclitaxel"                                                                                                                                
[10038] "Indomethacin_Interleukin-1-Alpha_Etoposide"                                                                                                                           
[10039] "Amphotericin-B_Colistin-Sulfate_Tobramycin"                                                                                                                           
[10040] "Cytarabine_Idarubicin_Interleukin-3"                                                                                                                                  
[10041] "Carboplatin_Cytarabine_Idarubicin"                                                                                                                                    
[10042] "Fluorouracil_Leucovorin-Calcium_Methylmercaptopurine-Riboside_PALA"                                                                                                   
[10043] "Cisplatin_Muramyl-TriPeptide-Phosphatidylethanolamine-Liposome"                                                                                                       
[10044] "Ifosfamide_Muramyl-TriPeptide-Phosphatidylethanolamine-Liposome"                                                                                                      
[10045] "Asparaginase_Daunorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                                         
[10046] "Cyclophosphamide_Cytarabine_Mercaptopurine_Vincristine"                                                                                                               
[10047] "Cyclophosphamide_Cytarabine_Doxorubicin_Vincristine"                                                                                                                  
[10048] "Etoposide_Ifosfamide_Methotrexate_Vincristine"                                                                                                                        
[10049] "Cyclophosphamide_Daunorubicin_Dexamethasone_Methotrexate_Pegaspargase_Vincristine"                                                                                    
[10050] "Dexamethasone_Mercaptopurine_Vincristine"                                                                                                                             
[10051] "Cyclophosphamide_Cytarabine_Pegaspargase"                                                                                                                             
[10052] "Cisplatin_Doxorubicin_Edatrexate_Vinblastine"                                                                                                                         
[10053] "Cytarabine_Etoposide_Ifosfamide_Mercaptopurine_Methotrexate"                                                                                                          
[10054] "Carboplatin_Cyclophosphamide_Etoposide_Vincristine"                                                                                                                   
[10055] "Carboplatin_Carmustine_Tamoxifen"                                                                                                                                     
[10056] "Cyclophosphamide_Interleukin-1-Alpha"                                                                                                                                 
[10057] "Carboplatin_Milodistim"                                                                                                                                               
[10058] "Busulfan_Cyclophosphamide_Cytarabine"                                                                                                                                 
[10059] "Cyclosporine_Tamoxifen_Vinblastine"                                                                                                                                   
[10060] "Interleukin-2_Interleukin-4_Tumor-Infiltrating-Lymphocytes"                                                                                                           
[10061] "Cytarabine_Tretinoin"                                                                                                                                                 
[10062] "Edatrexate_Ifosfamide"                                                                                                                                                
[10063] "Cisplatin_Etoposide_Tretinoin"                                                                                                                                        
[10064] "Asparaginase_Cisplatin_Cytarabine_Dexamethasone_Etoposide"                                                                                                            
[10065] "Cytarabine_Filgrastim_Tretinoin"                                                                                                                                      
[10066] "Carboplatin_Cyclophosphamide_Etoposide_Melphalan"                                                                                                                     
[10067] "Cyclophosphamide_Doxorubicin_Interleukin-3_Prednisone_Vincristine_Zidovudine"                                                                                         
[10068] "Dexrazoxane_Doxorubicin"                                                                                                                                              
[10069] "Doxorubicin_Vinorelbine"                                                                                                                                              
[10070] "Fluorouracil_Vinorelbine"                                                                                                                                             
[10071] "Carboplatin_Etoposide_Ifosfamide_Etanidazole"                                                                                                                         
[10072] "Bleomycin_Doxorubicin_Etoposide_Vincristine"                                                                                                                          
[10073] "Etoposide_Procarbazine_Vincristine"                                                                                                                                   
[10074] "Doxorubicin_Streptozocin"                                                                                                                                             
[10075] "Leucovorin-Calcium_Mercaptopurine_Methotrexate"                                                                                                                       
[10076] "Asparaginase_Mercaptopurine_Methotrexate"                                                                                                                             
[10077] "Fluorouracil_Leucovorin-Calcium_Mitomycin"                                                                                                                            
[10078] "Carboplatin_Thymidine"                                                                                                                                                
[10079] "Etoposide_Topotecan"                                                                                                                                                  
[10080] "Dexamethasone_Floxuridine_Leucovorin-Calcium"                                                                                                                         
[10081] "Amifostine_Cyclophosphamide"                                                                                                                                          
[10082] "Cyclosporine_Etoposide_Mitoxantrone"                                                                                                                                  
[10083] "Cyclophosphamide_Didanosine_Doxorubicin_Etoposide_Vincristine"                                                                                                        
[10084] "Cyclosporine_Cytarabine_Daunorubicin"                                                                                                                                 
[10085] "Cisplatin_Cytarabine_Hydroxyurea"                                                                                                                                     
[10086] "Cisplatin_Topotecan"                                                                                                                                                  
[10087] "Cyclophosphamide_Doxorubicin_Etoposide_Vincristine_Zidovudine"                                                                                                        
[10088] "Cyclophosphamide_Paclitaxel"                                                                                                                                          
[10089] "Estramustine_Vinblastine"                                                                                                                                             
[10090] "Cytarabine_Dexamethasone_Etoposide_Ifosfamide_Methotrexate_Vincristine"                                                                                               
[10091] "Bleomycin_Didanosine_Doxorubicin_Vincristine"                                                                                                                         
[10092] "Cyclosporine_Dactinomycin_Vincristine"                                                                                                                                
[10093] "Busulfan_Cyclophosphamide_Diaziquone"                                                                                                                                 
[10094] "Carboplatin_Cyclophosphamide_Interleukin-1-Beta"                                                                                                                      
[10095] "Carboplatin_Paclitaxel"                                                                                                                                               
[10096] "Doxorubicin_Fluorouracil_Vinorelbine"                                                                                                                                 
[10097] "Etoposide_Paclitaxel"                                                                                                                                                 
[10098] "Doxorubicin_Fluorouracil_Leucovorin-Calcium_Vinorelbine"                                                                                                              
[10099] "Interferon-Gamma_Melphalan_Tumor-Necrosis-Factor"                                                                                                                     
[10100] "Altretamine_Paclitaxel"                                                                                                                                               
[10101] "Carboplatin_Cisplatin_Paclitaxel"                                                                                                                                     
[10102] "Paclitaxel_Topotecan"                                                                                                                                                 
[10103] "Eflornithine_Piroxicam"                                                                                                                                               
[10104] "Chlorambucil_Cladribine"                                                                                                                                              
[10105] "Hydrocortisone_Mitoxantrone"                                                                                                                                          
[10106] "Cytarabine_Daunorubicin_Etoposide_Interleukin-3"                                                                                                                      
[10107] "Cytarabine_Dexverapamil_Etoposide_Idarubicin"                                                                                                                         
[10108] "Doxorubicin_Melphalan_Methylprednisolone"                                                                                                                             
[10109] "Melphalan_Methylprednisolone"                                                                                                                                         
[10110] "Cytarabine_Mercaptopurine"                                                                                                                                            
[10111] "Cyclosporine_Vinblastine"                                                                                                                                             
[10112] "Tamoxifen_Vinblastine"                                                                                                                                                
[10113] "Asparaginase_Cyclophosphamide_Cytarabine_Daunorubicin_Doxorubicin_Mercaptopurine_Vincristine"                                                                         
[10114] "Asparaginase_Cyclophosphamide_Cytarabine_Daunorubicin_Mercaptopurine_Methotrexate_Vincristine"                                                                        
[10115] "Asparaginase_Daunorubicin_Dexamethasone_Ifosfamide_Mercaptopurine_Methotrexate_Vindesine"                                                                             
[10116] "Asparaginase_Cytarabine_Dexamethasone_Etoposide"                                                                                                                      
[10117] "Dactinomycin_Doxorubicin_Etoposide_Ifosfamide_Vincristine"                                                                                                            
[10118] "Cytarabine_Idarubicin_Teniposide"                                                                                                                                     
[10119] "Cyclosporine_Paclitaxel"                                                                                                                                              
[10120] "Dexverapamil_Paclitaxel"                                                                                                                                              
[10121] "Ifosfamide_Paclitaxel"                                                                                                                                                
[10122] "Etoposide_Tretinoin"                                                                                                                                                  
[10123] "Aminoglutethimide_Suramin"                                                                                                                                            
[10124] "PSC-833_Vinblastine"                                                                                                                                                  
[10125] "Cytarabine_Fludarabine_Idarubicin"                                                                                                                                    
[10126] "Cisplatin_Fluorouracil_Paclitaxel"                                                                                                                                    
[10127] "Cisplatin_Estramustine_Etoposide"                                                                                                                                     
[10128] "Cisplatin_Decitabine"                                                                                                                                                 
[10129] "Cisplatin_Doxorubicin_Etoposide_Vincristine"                                                                                                                          
[10130] "Carboplatin_Estramustine_Etoposide"                                                                                                                                   
[10131] "Cyclophosphamide_Epirubicin"                                                                                                                                          
[10132] "Epoetin-Alfa_Interleukin-3"                                                                                                                                           
[10133] "Interleukin-2_Macrophage-Colony-Stimulating-Factor"                                                                                                                   
[10134] "Bicalutamide_Leuprolide"                                                                                                                                              
[10135] "Bicalutamide_Goserelin"                                                                                                                                               
[10136] "Fluorouracil_Triacetyluridine"                                                                                                                                        
[10137] "Cisplatin_Floxuridine_Leucovorin-Calcium"                                                                                                                             
[10138] "Carmustine_Cisplatin_Thiotepa"                                                                                                                                        
[10139] "Carboplatin_Cisplatin_Cyclophosphamide_Etoposide"                                                                                                                     
[10140] "Leuprolide_Suramin"                                                                                                                                                   
[10141] "Aminoglutethimide_Leuprolide"                                                                                                                                         
[10142] "Ketoconazole_Paclitaxel"                                                                                                                                              
[10143] "Carboplatin_Interleukin-1-Alpha_Methylene-Blue"                                                                                                                       
[10144] "Asparaginase_Cytarabine_Dexamethasone_Doxorubicin_Mercaptopurine_Vincristine"                                                                                         
[10145] "Asparaginase_Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Mercaptopurine_Vincristine"                                                                        
[10146] "Asparaginase_Cyclophosphamide_Cytarabine_Dexamethasone_Mercaptopurine_Methotrexate_Vincristine"                                                                       
[10147] "Cyclosporine_Interleukin-2_Methylprednisolone"                                                                                                                        
[10148] "Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Vincristine_Zidovudine"                                                                                             
[10149] "Interleukin-2_Monoclonal-Antibody-14G2A_Sargramostim"                                                                                                                 
[10150] "Cisplatin_Cytarabine_Etoposide_Prednisone"                                                                                                                            
[10151] "Dexamethasone_Methotrexate_Thiotepa_Vincristine"                                                                                                                      
[10152] "Carboplatin_Etoposide_Ifosfamide_Vincristine"                                                                                                                         
[10153] "Busulfan_Cyclophosphamide_Cytarabine_Sargramostim"                                                                                                                    
[10154] "Filgrastim_Fludarabine"                                                                                                                                               
[10155] "Thioguanine_Tiazofurin"                                                                                                                                               
[10156] "Filgrastim_Merbarone"                                                                                                                                                 
[10157] "Edatrexate_Paclitaxel"                                                                                                                                                
[10158] "Fluorouracil_Gallium-Nitrate"                                                                                                                                         
[10159] "Paclitaxel_Quinine"                                                                                                                                                   
[10160] "Floxuridine_Leucovorin-Calcium_PALA"                                                                                                                                  
[10161] "Cytarabine_Dexamethasone_Etoposide_Vincristine"                                                                                                                       
[10162] "Cyclophosphamide_Cytarabine_Daunorubicin_Thioguanine"                                                                                                                 
[10163] "Dexamethasone_Floxuridine_Mitomycin"                                                                                                                                  
[10164] "Cisplatin_Edatrexate_Ifosfamide"                                                                                                                                      
[10165] "Busulfan_Cyclophosphamide_Mitoxantrone"                                                                                                                               
[10166] "Floxuridine_Mitomycin"                                                                                                                                                
[10167] "Doxorubicin_Topotecan"                                                                                                                                                
[10168] "Methotrexate_Zidovudine"                                                                                                                                              
[10169] "Daunorubicin_Methylprednisolone_Vincristine"                                                                                                                          
[10170] "Cytarabine_Methotrexate_Teniposide_Thioguanine"                                                                                                                       
[10171] "Asparaginase_Cyclophosphamide_Mercaptopurine_Methotrexate"                                                                                                            
[10172] "Cytarabine_Mercaptopurine_Methotrexate_Teniposide_Thioguanine"                                                                                                        
[10173] "Etoposide_Mitoxantrone_Prednisone_Vincristine"                                                                                                                        
[10174] "Carboplatin_Thiotepa"                                                                                                                                                 
[10175] "Cisplatin_Etoposide_Vincristine"                                                                                                                                      
[10176] "Doxorubicin_Edatrexate"                                                                                                                                               
[10177] "Filgrastim_Tretinoin"                                                                                                                                                 
[10178] "Cyclophosphamide_Procarbazine_Vincristine"                                                                                                                            
[10179] "Dexamethasone_Doxorubicin_Prednisone_Quinine_Vincristine"                                                                                                             
[10180] "Dexamethasone_Doxorubicin_Prednisone_Vincristine"                                                                                                                     
[10181] "Estramustine_Etoposide"                                                                                                                                               
[10182] "Interferon-Beta_Isotretinoin"                                                                                                                                         
[10183] "Beta-Carotene_Vitamin-A"                                                                                                                                              
[10184] "Dipyridamole_Fluorouracil_Leucovorin-Calcium_Mitomycin"                                                                                                               
[10185] "Methotrexate_Paclitaxel"                                                                                                                                              
[10186] "Filgrastim_Methotrexate_Paclitaxel"                                                                                                                                   
[10187] "Cyclophosphamide_Doxorubicin_Paclitaxel"                                                                                                                              
[10188] "Cisplatin_Etoposide_Fluorouracil_Leucovorin-Calcium"                                                                                                                  
[10189] "Etoposide_Ifosfamide_Melphalan"                                                                                                                                       
[10190] "Cisplatin_Interleukin-1-Alpha"                                                                                                                                        
[10191] "Carboplatin_Etoposide_Interleukin-6_Sargramostim"                                                                                                                     
[10192] "Ciprofloxacin_Cisplatin_Cyclophosphamide_Etoposide_Pentoxifylline"                                                                                                    
[10193] "Carmustine_Cyclophosphamide_Etoposide_Melphalan"                                                                                                                      
[10194] "Doxorubicin_Hydroxyurea"                                                                                                                                              
[10195] "Lomustine_Methotrexate"                                                                                                                                               
[10196] "Estramustine_Paclitaxel"                                                                                                                                              
[10197] "Edatrexate_Filgrastim_Paclitaxel"                                                                                                                                     
[10198] "Carboplatin_Etoposide_Ifosfamide_Milodistim"                                                                                                                          
[10199] "Fluorouracil_Leucovorin-Calcium_Methotrexate_PALA_Triacetyluridine"                                                                                                   
[10200] "Fluorouracil_Leucovorin-Calcium_Paclitaxel"                                                                                                                           
[10201] "Filgrastim_Fluorouracil_Leucovorin-Calcium_Paclitaxel"                                                                                                                
[10202] "Edatrexate_Leucovorin-Calcium"                                                                                                                                        
[10203] "Cyclosporine_Cytarabine_Etoposide_Mitoxantrone"                                                                                                                       
[10204] "Cyclophosphamide_Doxorubicin_Methotrexate_Methylprednisolone_Prednisone_Vincristine"                                                                                  
[10205] "Cisplatin_Etoposide_Tamoxifen"                                                                                                                                        
[10206] "BCG_Bropirimine"                                                                                                                                                      
[10207] "Cyclophosphamide_Doxorubicin_Fluorouracil_Leucovorin-Calcium_Milodistim"                                                                                              
[10208] "Carboplatin_Fluorouracil_Vincristine"                                                                                                                                 
[10209] "Filgrastim_Pyrazoloacridine"                                                                                                                                          
[10210] "Filgrastim_Paclitaxel_Topotecan"                                                                                                                                      
[10211] "Cisplatin_Cyclosporine_Doxorubicin"                                                                                                                                   
[10212] "Cisplatin_Pentoxifylline"                                                                                                                                             
[10213] "Methotrexate_Pegaspargase"                                                                                                                                            
[10214] "Cisplatin_Etoposide_Filgrastim_Ifosfamide_Interleukin-3"                                                                                                              
[10215] "Cisplatin_Filgrastim_Ifosfamide_Interleukin-3_Vinblastine"                                                                                                            
[10216] "Bleomycin_Cyclophosphamide_Doxorubicin_Prednisolone_Vindesine"                                                                                                        
[10217] "Fazarabine_Filgrastim"                                                                                                                                                
[10218] "Cyclophosphamide_Topotecan"                                                                                                                                           
[10219] "Cisplatin_Cyclophosphamide_Thiotepa"                                                                                                                                  
[10220] "Gallium-Nitrate_Ifosfamide_Vinblastine"                                                                                                                               
[10221] "Busulfan_Thiotepa"                                                                                                                                                    
[10222] "Mitoxantrone_Paclitaxel_Thiotepa"                                                                                                                                     
[10223] "Busulfan_Ciprofloxacin_Cyclophosphamide_Pentoxifylline"                                                                                                               
[10224] "Busulfan_Melphalan_Thiotepa"                                                                                                                                          
[10225] "Busulfan_ciprofloxacin_Melphalan_Pentoxifylline_Thiotepa"                                                                                                             
[10226] "Carboxypeptidase-G2_Leucovorin-Calcium_Methotrexate"                                                                                                                  
[10227] "Asparaginase_Daunorubicin_Prednisolone_Vindesine"                                                                                                                     
[10228] "Cytarabine_Etoposide_Ifosfamide_Methotrexate_Prednisolone"                                                                                                            
[10229] "Doxorubicin_Prednisolone_Vincristine"                                                                                                                                 
[10230] "Cyclophosphamide_Prednisolone"                                                                                                                                        
[10231] "Cytarabine_Dexamethasone_Ifosfamide_Methotrexate_Teniposide_Vincristine"                                                                                              
[10232] "Cytarabine_Dexamethasone_Etoposide_Vindesine"                                                                                                                         
[10233] "Doxorubicin_Etoposide_Mitotane_Vincristine"                                                                                                                           
[10234] "Cyclophosphamide_Methotrexate"                                                                                                                                        
[10235] "Carmustine_Dacarbazine_Thymidine"                                                                                                                                     
[10236] "Cytarabine_Ifosfamide"                                                                                                                                                
[10237] "Cyclophosphamide_Indomethacin_Interleukin-2_Tumor-Infiltrating-Lymphocytes"                                                                                           
[10238] "Indomethacin_Interleukin-2_Lymphokine-Activated-Killer-Cells"                                                                                                         
[10239] "Hydroxyurea_Tretinoin"                                                                                                                                                
[10240] "Cisplatin_Vinorelbine"                                                                                                                                                
[10241] "Asparaginase_Vincristine"                                                                                                                                             
[10242] "Dipyridamole_Methotrexate"                                                                                                                                            
[10243] "Cyclophosphamide_Epirubicin_Tamoxifen"                                                                                                                                
[10244] "Cyclophosphamide_Doxorubicin_Toremifene"                                                                                                                              
[10245] "Cyclophosphamide_Epirubicin_Toremifene"                                                                                                                               
[10246] "Cytarabine_Dexamethasone_Etoposide_Ifosfamide_Methotrexate"                                                                                                           
[10247] "Cyclophosphamide_Dexamethasone_Doxorubicin_Methotrexate"                                                                                                              
[10248] "Cyclophosphamide_Dexamethasone"                                                                                                                                       
[10249] "Bryostatin-1_Tretinoin"                                                                                                                                               
[10250] "Floxuridine_Hydroxyurea_Leucovorin-Calcium"                                                                                                                           
[10251] "Carboplatin_Cytarabine_Hydroxyurea"                                                                                                                                   
[10252] "Cyclophosphamide_Perflubron"                                                                                                                                          
[10253] "Carboplatin_Topotecan"                                                                                                                                                
[10254] "Cytarabine_Topotecan"                                                                                                                                                 
[10255] "Cyclophosphamide_Doxorubicin_Filgrastim_Fluorouracil_Leucovorin-Calcium"                                                                                              
[10256] "Cisplatin_Etoposide_Paclitaxel"                                                                                                                                       
[10257] "Cisplatin_Etoposide_Filgrastim_Paclitaxel"                                                                                                                            
[10258] "Filgrastim_Penclomedine"                                                                                                                                              
[10259] "Doxorubicin_Methotrexate"                                                                                                                                             
[10260] "Cisplatin_Doxorubicin_Methotrexate_Muramyl-TriPeptide-Phosphatidylethanolamine"                                                                                       
[10261] "Cisplatin_Ifosfamide_Muramyl-TriPeptide-Phosphatidylethanolamine"                                                                                                     
[10262] "Carboplatin_Interleukin-6_Sargramostim"                                                                                                                               
[10263] "Carboplatin_Filgrastim_Topotecan"                                                                                                                                     
[10264] "Bleomycin_Cisplatin_Etoposide_Ifosfamide_Vinblastine"                                                                                                                 
[10265] "Cisplatin_Doxorubicin_Floxuridine_Leucovorin-Calcium"                                                                                                                 
[10266] "Cisplatin_Dexamethasone_Doxorubicin_Floxuridine_Leucovorin-Calcium"                                                                                                   
[10267] "Cyclosporine_Dexamethasone_Vinblastine"                                                                                                                               
[10268] "Carboplatin_Cisplatin_Cyclophosphamide_Etoposide_Paclitaxel"                                                                                                          
[10269] "Fluorouracil_Irinotecan_Leucovorin-Calcium"                                                                                                                           
[10270] "Gallium-Nitrate_Hydroxyurea"                                                                                                                                          
[10271] "Cyclophosphamide_Milodistim"                                                                                                                                          
[10272] "Carboplatin_Cyclophosphamide_Milodistim_Thiotepa"                                                                                                                     
[10273] "Cytarabine_Doxorubicin_Prednisone_Thioguanine_Vincristine"                                                                                                            
[10274] "Interleukin-1-Alpha_Methotrexate"                                                                                                                                     
[10275] "Lomustine_Vincristine"                                                                                                                                                
[10276] "Interferon-Gamma_Interleukin-2_Melphalan_Tumor-Necrosis-Factor"                                                                                                       
[10277] "Cyclophosphamide_Filgrastim_Topotecan"                                                                                                                                
[10278] "Methotrexate_Procarbazine_Vincristine"                                                                                                                                
[10279] "Cyclophosphamide_Idarubicin_Prednisone_Vincristine"                                                                                                                   
[10280] "Carboplatin_Filgrastim_Paclitaxel"                                                                                                                                    
[10281] "Asparaginase_Cytarabine_Filgrastim"                                                                                                                                   
[10282] "Cisplatin_Etoposide_Filgrastim"                                                                                                                                       
[10283] "Ciprofloxacin_Cisplatin_Etoposide"                                                                                                                                    
[10284] "Ciprofloxacin_Cisplatin_Etoposide_filgrastim"                                                                                                                         
[10285] "Dacarbazine_Interleukin-1-Alpha"                                                                                                                                      
[10286] "Cyclophosphamide_Etoposide_Filgrastim"                                                                                                                                
[10287] "Cytarabine_Milodistim_Mitoxantrone"                                                                                                                                   
[10288] "Paclitaxel_PSC-833"                                                                                                                                                   
[10289] "Cyclosporine_Methotrexate"                                                                                                                                            
[10290] "Dexamethasone_Vincristine"                                                                                                                                            
[10291] "Etoposide_Interleukin-1-Alpha"                                                                                                                                        
[10292] "Carboplatin_Etoposide_Tamoxifen"                                                                                                                                      
[10293] "Cisplatin_Ifosfamide_Paclitaxel"                                                                                                                                      
[10294] "Cyclophosphamide_Doxorubicin_Etoposide_Prednisone"                                                                                                                    
[10295] "Cytarabine_Homoharringtonine"                                                                                                                                         
[10296] "Cytarabine_Mitoxantrone_Sargramostim"                                                                                                                                 
[10297] "Cytarabine_Idarubicin_Sargramostim"                                                                                                                                   
[10298] "Aminocamptothecin_Filgrastim"                                                                                                                                         
[10299] "Bleomycin_Doxorubicin_Etoposide_Prednisolone_Vincristine"                                                                                                             
[10300] "Chlorambucil_Prednisolone_Procarbazine_Vinblastine"                                                                                                                   
[10301] "Cisplatin_Cyclophosphamide_Etoposide_Filgrastim"                                                                                                                      
[10302] "Cisplatin_Cytarabine_Idarubicin_Methylprednisolone"                                                                                                                   
[10303] "Bleomycin_Idarubicin_Methylprednisolone_Vincristine"                                                                                                                  
[10304] "Filgrastim_Interleukin-6"                                                                                                                                             
[10305] "Carboplatin_Etoposide_Filgrastim_Ifosfamide_Interleukin-6"                                                                                                            
[10306] "Cyclophosphamide_Topotecan_Vincristine"                                                                                                                               
[10307] "Dacarbazine_Doxorubicin_Filgrastim_Ifosfamide"                                                                                                                        
[10308] "Carboplatin_Pentoxifylline"                                                                                                                                           
[10309] "Bleomycin_Cisplatin_Etoposide_Mitomycin"                                                                                                                              
[10310] "Mitoxantrone_Paclitaxel"                                                                                                                                              
[10311] "Cisplatin_Tumor-Necrosis-Factor"                                                                                                                                      
[10312] "Busulfan_Cyclophosphamide_Thiotepa"                                                                                                                                   
[10313] "Cytarabine_Filgrastim_Idarubicin_Interleukin-6"                                                                                                                       
[10314] "Cytarabine_Etoposide_Filgrastim_Interleukin-6_Mitoxantrone"                                                                                                           
[10315] "Cyclophosphamide_Filgrastim_Interleukin-6"                                                                                                                            
[10316] "Carboplatin_Etoposide_Filgrastim_Ifosfamide_Paclitaxel"                                                                                                               
[10317] "Carboplatin_Etoposide_Ifosfamide_Paclitaxel"                                                                                                                          
[10318] "Melphalan_Paclitaxel"                                                                                                                                                 
[10319] "Cyclophosphamide_Mitoxantrone_Prednisolone_Vincristine"                                                                                                               
[10320] "Carboplatin_Cyclosporine_Paclitaxel"                                                                                                                                  
[10321] "Cisplatin_Filgrastim_Topotecan"                                                                                                                                       
[10322] "Bleomycin_Cisplatin_Epoetin-Alfa_Etoposide_Filgrastim_Ifosfamide_Vinblastine"                                                                                         
[10323] "Cisplatin_Epoetin-Alfa_Etoposide_Filgrastim_Ifosfamide"                                                                                                               
[10324] "Carboplatin_Filgrastim_Interleukin-6_Paclitaxel"                                                                                                                      
[10325] "Benznidazole_Lomustine"                                                                                                                                               
[10326] "Flutamide_Goserelin_Suramin"                                                                                                                                          
[10327] "Carboplatin_Etoposide_Vincristine"                                                                                                                                    
[10328] "Doxorubicin_Filgrastim_Ifosfamide"                                                                                                                                    
[10329] "Goserelin_Tamoxifen"                                                                                                                                                  
[10330] "Leuprolide_Tamoxifen"                                                                                                                                                 
[10331] "Cyclophosphamide_Fluorouracil_Leuprolide_Methotrexate_Tamoxifen"                                                                                                      
[10332] "Cyclophosphamide_Fluorouracil_Goserelin_Methotrexate_Tamoxifen"                                                                                                       
[10333] "Cyclophosphamide_Doxorubicin_Leuprolide_Tamoxifen"                                                                                                                    
[10334] "Cyclophosphamide_Doxorubicin_Goserelin_Tamoxifen"                                                                                                                     
[10335] "Asparaginase_Cytarabine_Etoposide_Methotrexate_Prednisone_Thioguanine_Vincristine"                                                                                    
[10336] "Altretamine_Etoposide"                                                                                                                                                
[10337] "Dexamethasone_Dexniguldipine_Doxorubicin_Prednisone_Vincristine"                                                                                                      
[10338] "Dexamethasone_Dexniguldipine_Doxorubicin_Vincristine"                                                                                                                 
[10339] "Filgrastim_Stem-Cell-Factor"                                                                                                                                          
[10340] "Gallium-Nitrate_Paclitaxel"                                                                                                                                           
[10341] "Filgrastim_Gallium-Nitrate_Paclitaxel"                                                                                                                                
[10342] "Paclitaxel_Thiotepa"                                                                                                                                                  
[10343] "Carmustine_O6-Benzylguanine"                                                                                                                                          
[10344] "Cyclophosphamide_Didanosine_Doxorubicin_Etoposide"                                                                                                                    
[10345] "Antineoplaston-A10_Antineoplaston-AS2-1"                                                                                                                              
[10346] "Cisplatin_Cytarabine_Dexamethasone_Idarubicin"                                                                                                                        
[10347] "Cisplatin_Cytarabine_Dexamethasone_Idarubicin_Methotrexate"                                                                                                           
[10348] "Etoposide_Fluorouracil"                                                                                                                                               
[10349] "Carboplatin_Milodistim_Paclitaxel"                                                                                                                                    
[10350] "Cisplatin_Dacarbazine_Interleukin-2_Vinblastine"                                                                                                                      
[10351] "Cytarabine_Filgrastim_Idarubicin"                                                                                                                                     
[10352] "Cytarabine_Etoposide_Filgrastim_Mitoxantrone"                                                                                                                         
[10353] "Dexamethasone_Methotrexate_Procarbazine_Vincristine"                                                                                                                  
[10354] "Carboplatin_Cyclophosphamide_Filgrastim"                                                                                                                              
[10355] "Cisplatin_Pyrazoloacridine"                                                                                                                                           
[10356] "Cisplatin_Filgrastim_Pyrazoloacridine"                                                                                                                                
[10357] "Carboxyamidotriazole_Paclitaxel"                                                                                                                                      
[10358] "Cyclophosphamide_Doxorubicin_Methylprednisolone_Vincristine"                                                                                                          
[10359] "BMS-182751_Etoposide"                                                                                                                                                 
[10360] "Cyclophosphamide_Dexamethasone_Doxorubicin_Etoposide"                                                                                                                 
[10361] "Isotretinoin_Vitamine-E"                                                                                                                                              
[10362] "Dexverapamil_Vinblastine"                                                                                                                                             
[10363] "Cisplatin_Docetaxel_Fluorouracil_Leucovorin-Calcium"                                                                                                                  
[10364] "Cisplatin_Doxorubicin_Paclitaxel"                                                                                                                                     
[10365] "Cisplatin_Doxorubicin_Filgrastim_Paclitaxel"                                                                                                                          
[10366] "Etoposide_Mitoxantrone_Sargramostim"                                                                                                                                  
[10367] "Etoposide_Novobiocin"                                                                                                                                                 
[10368] "Cisplatin_Tirapazamine"                                                                                                                                               
[10369] "Bleomycin_Cyclophosphamide_Doxorubicin_Prednisone_Procarbazine_Vinblastine_Vincristine"                                                                               
[10370] "Cisplatin_Epirubicin_Fluorouracil"                                                                                                                                    
[10371] "Prednisone_Thioguanine_Vincristine"                                                                                                                                   
[10372] "Carboplatin_Etoposide_Mitoxantrone_Thiotepa"                                                                                                                          
[10373] "CI-980_Filgrastim"                                                                                                                                                    
[10374] "Dexamethasone_Etoposide_Ifosfamide_Methotrexate_Pegaspargase_Vincristine"                                                                                             
[10375] "Cytarabine_Dexamethasone_Etoposide_Idarubicin_Ifosfamide_Methotrexate_Pegaspargase_Thioguanine_Vincristine"                                                           
[10376] "Cytarabine_Dexamethasone_Etoposide_Methotrexate_Pegaspargase_Thioguanine_Vincristine"                                                                                 
[10377] "Dexamethasone_Idarubicin_Ifosfamide_Methotrexate_Thioguanine_Vincristine"                                                                                             
[10378] "Methotrexate_Thioguanine_Vincristine"                                                                                                                                 
[10379] "Carmustine_Mitolactol"                                                                                                                                                
[10380] "Interleukin-2_Monoclonal-Antibody-Ch14-18_Monoclonal-Antibody-R24"                                                                                                    
[10381] "Carboplatin_Cyclophosphamide_Paclitaxel"                                                                                                                              
[10382] "Carboplatin_Cyclophosphamide_Filgrastim_Paclitaxel"                                                                                                                   
[10383] "Cisplatin_Epoetin-Alfa_Iron"                                                                                                                                          
[10384] "Detox_Keyhole-Limpet-Hemocyanin_Sialyl-Tn-Antigen"                                                                                                                    
[10385] "CT-1501R_Interleukin-2"                                                                                                                                               
[10386] "ImmTher_Indomethacin"                                                                                                                                                 
[10387] "Cisplatin_Safingol"                                                                                                                                                   
[10388] "Doxorubicin_Ketoconazole"                                                                                                                                             
[10389] "Cytarabine_Dexamethasone_Etoposide_Idarubicin_Thioguanine"                                                                                                            
[10390] "Cisplatin_Cyclophosphamide_Filgrastim_Paclitaxel"                                                                                                                     
[10391] "Hydroxyurea_Pentoxifylline"                                                                                                                                           
[10392] "Flutamide_Isotretinoin_Leuprolide"                                                                                                                                    
[10393] "Interleukin-2_MART-1-Antigen"                                                                                                                                         
[10394] "Cisplatin_Irinotecan"                                                                                                                                                 
[10395] "Cisplatin_Doxorubicin_Tamoxifen"                                                                                                                                      
[10396] "Etoposide_Mitoxantrone_PSC-833"                                                                                                                                       
[10397] "Estramustine_Vinorelbine"                                                                                                                                             
[10398] "Folic-Acid_Lometrexol"                                                                                                                                                
[10399] "Cisplatin_Docetaxel"                                                                                                                                                  
[10400] "Bleomycin_Cisplatin_Cyclophosphamide_Etoposide"                                                                                                                       
[10401] "Carmustine_Temozolomide"                                                                                                                                              
[10402] "Fluorouracil_Levamisole_L-Leucovorin"                                                                                                                                 
[10403] "Carbogen_Niacinamide"                                                                                                                                                 
[10404] "Leucovorin-Calcium_Tegafur_Uracil"                                                                                                                                    
[10405] "Fludarabine_Mitoxantrone"                                                                                                                                             
[10406] "Ifosfamide_Vinorelbine"                                                                                                                                               
[10407] "Fluorouracil_L-Leucovorin_Methotrexate"                                                                                                                               
[10408] "Cytarabine_Daunorubicin_Etoposide_Filgrastim"                                                                                                                         
[10409] "Busulfan_Cytarabine_Melphalan"                                                                                                                                        
[10410] "Dexverapamil_Doxorubicin"                                                                                                                                             
[10411] "Daunorubicin_Pegaspargase_Prednisone_Vincristine"                                                                                                                     
[10412] "Daunorubicin_Milodistim_Pegaspargase_Prednisone_Vincristine"                                                                                                          
[10413] "Interleukin-2_NG-Monomethyl-L-Arginine"                                                                                                                               
[10414] "Leucovorin-Calcium_Trimetrexate-Glucuronate"                                                                                                                          
[10415] "Cyclophosphamide_Fluorouracil_Pirarubicin"                                                                                                                            
[10416] "Dacarbazine_Pirarubicin"                                                                                                                                              
[10417] "Zalcitabine_Zidovudine"                                                                                                                                               
[10418] "Cyclophosphamide_Interferon-Alfa_Interleukin-2"                                                                                                                       
[10419] "Interferon-Alfa_Vinblastine"                                                                                                                                          
[10420] "Fluorouracil_Interferon-Alfa"                                                                                                                                         
[10421] "Interferon-Alfa_Sargramostim_Zidovudine"                                                                                                                              
[10422] "Doxorubicin_eflornithine_Interferon-Alfa"                                                                                                                             
[10423] "Interferon-Alfa_Prednisone"                                                                                                                                           
[10424] "Interferon-Alfa_Tamoxifen"                                                                                                                                            
[10425] "Fluorouracil_Interferon-Alfa_Mitomycin"                                                                                                                               
[10426] "Eflornithine_Interferon-Alfa"                                                                                                                                         
[10427] "Interferon-Alfa_Interleukin-2_Tumor-Infiltrating-Lymphocytes"                                                                                                         
[10428] "Dexamethasone_Doxorubicin_Interferon-Alfa_Vincristine"                                                                                                                
[10429] "Cisplatin_Interferon-Alfa_Interleukin-2"                                                                                                                              
[10430] "Cyclophosphamide_Doxorubicin_Interferon-Alfa_Prednisone_Vincristine"                                                                                                  
[10431] "Fluorouracil_Interferon-Alfa_PALA"                                                                                                                                    
[10432] "Mitoxantrone_Interferon-Alfa"                                                                                                                                         
[10433] "Interferon-Alfa_Zidovudine"                                                                                                                                           
[10434] "Lomustine_Interferon-Alfa"                                                                                                                                            
[10435] "Cyclophosphamide_Interferon-Alfa_Interleukin-2_Tumor-Infiltrating-Lymphocytes"                                                                                        
[10436] "Interferon-Alfa_Piroxicam"                                                                                                                                            
[10437] "Cyclophosphamide_Interferon-Alfa_Prednisone"                                                                                                                          
[10438] "Cisplatin_Interferon-Alfa"                                                                                                                                            
[10439] "Interferon-Alfa_Interferon-Gamma"                                                                                                                                     
[10440] "Doxorubicin_Interferon-Alfa"                                                                                                                                          
[10441] "Interferon-Alfa_Interleukin-2"                                                                                                                                        
[10442] "Interferon-Alfa_Isotretinoin"                                                                                                                                         
[10443] "Carmustine_Interferon-Alfa"                                                                                                                                           
[10444] "Cyclophosphamide_Interferon-Alfa"                                                                                                                                     
[10445] "Interferon-Alfa_Mercaptopurine_Methotrexate"                                                                                                                          
[10446] "Interferon-Alfa_Interleukin-2_Lymphokine-Activated-Killer-Cells"                                                                                                      
[10447] "Fluorouracil_Interferon-Alfa_Leucovorin-Calcium"                                                                                                                      
[10448] "Carmustine_Cyclophosphamide_Interferon-Alfa_Melphalan_Prednisone_Vincristine"                                                                                         
[10449] "Cisplatin_Interferon-Alfa_Tamoxifen"                                                                                                                                  
[10450] "Interferon-Alfa_Melphalan_Prednisone"                                                                                                                                 
[10451] "Interferon-Alfa_Poly-ICLC"                                                                                                                                            
[10452] "Cisplatin_Cyclophosphamide_Interferon-Alfa"                                                                                                                           
[10453] "Cisplatin_Etoposide_Interferon-Alfa"                                                                                                                                  
[10454] "Carboplatin_Interferon-Alfa"                                                                                                                                          
[10455] "Cyclophosphamide_Interferon-Alfa_Melphalan_Prednisone_Vincristine"                                                                                                    
[10456] "Carmustine_Cisplatin_Dacarbazine_Interferon-Alfa_Tamoxifen"                                                                                                           
[10457] "Floxuridine_Fluorouracil_Interferon-Alfa_Leucovorin-Calcium"                                                                                                          
[10458] "Floxuridine_Interferon-Alfa_Mitomycin"                                                                                                                                
[10459] "Cisplatin_Fluorouracil_Interferon-Alfa_Leucovorin-Calcium"                                                                                                            
[10460] "Fluorouracil_Interferon-Alfa_Interleukin-2"                                                                                                                           
[10461] "Cytarabine_Interferon-Alfa"                                                                                                                                           
[10462] "Fludarabine_Interferon-Alfa"                                                                                                                                          
[10463] "Fluorouracil_Interferon-Alfa_Leucovorin-Calcium_Methotrexate"                                                                                                         
[10464] "Cisplatin_Interferon-Alfa_Interleukin-2_Vinblastine"                                                                                                                  
[10465] "Cisplatin_Fluorouracil_Interferon-Alfa"                                                                                                                               
[10466] "Dacarbazine_Interferon-Alfa"                                                                                                                                          
[10467] "Dacarbazine_Interferon-Alfa_Tamoxifen"                                                                                                                                
[10468] "Carboplatin_Cisplatin_Interferon-Alfa_Tamoxifen"                                                                                                                      
[10469] "Interferon-Alfa_Interleukin-2_Monoclonal-Antibody-R24"                                                                                                                
[10470] "Filgrastim_Fluorouracil_Interferon-Alfa"                                                                                                                              
[10471] "Cyclophosphamide_Doxorubicin_Fluorouracil_Interferon-Alfa"                                                                                                            
[10472] "Interferon-Alfa_Interleukin-2_Tumor-Necrosis-Factor"                                                                                                                  
[10473] "Chlorambucil_Interferon-Alfa"                                                                                                                                         
[10474] "Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide_filgrastim"                                                                                                          
[10475] "Hydroxyurea_Interferon-Alfa"                                                                                                                                          
[10476] "Carboplatin_Etoposide_Interferon-Alfa_Mitoxantrone"                                                                                                                   
[10477] "Interferon-Alfa_Megestrol_Tamoxifen"                                                                                                                                  
[10478] "Fluorouracil_Interferon-Alfa_Leucovorin-Calcium_Mitomycin"                                                                                                            
[10479] "Floxuridine_Interferon-Alfa"                                                                                                                                          
[10480] "Cisplatin_Etoposide_Fluorouracil_Interferon-Alfa"                                                                                                                     
[10481] "Allopurinol_Fluorouracil_Interferon-Alfa"                                                                                                                             
[10482] "Interferon-Alfa_Tretinoin"                                                                                                                                            
[10483] "Fluorouracil_Interferon-Alfa_Interferon-Gamma_Leucovorin-Calcium"                                                                                                     
[10484] "Bleomycin_Doxorubicin_Vincristine_Zalcitabine"                                                                                                                        
[10485] "Bleomycin_Cisplatin_Ifosfamide_Interferon-Alfa"                                                                                                                       
[10486] "Interferon-Alfa_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                                                   
[10487] "Busulfan_Interferon-Alfa"                                                                                                                                             
[10488] "Filgrastim_Interferon-Alfa"                                                                                                                                           
[10489] "Hydralazine_Interferon-Alfa"                                                                                                                                          
[10490] "Carmustine_Fluorouracil_Interferon-Alfa"                                                                                                                              
[10491] "Carmustine_Doxorubicin_Interferon-Alfa_Prednisone_Vincristine"                                                                                                        
[10492] "Busulfan_Cyclophosphamide_Interferon-Alfa_Zidovudine"                                                                                                                 
[10493] "Fluorouracil_Hydroxyurea_Interferon-Alfa"                                                                                                                             
[10494] "Doxorubicin_Interferon-Alfa_Tretinoin"                                                                                                                                
[10495] "Cisplatin_Dacarbazine_Interferon-Alfa_Tamoxifen"                                                                                                                      
[10496] "Ifosfamide_Interferon-Alfa_Pentostatin"                                                                                                                               
[10497] "Fluorouracil_Interferon-Alfa_Leucovorin-Calcium_Sargramostim"                                                                                                         
[10498] "Carmustine_Cyclophosphamide_Etoposide_Interferon-Alfa"                                                                                                                
[10499] "Bleomycin_Cyclophosphamide_Cytarabine_Doxorubicin_Etoposide_filgrastim_Methotrexate_Prednisone_Vincristine"                                                           
[10500] "Dexamethasone_Interferon-Alfa"                                                                                                                                        
[10501] "Cisplatin_Dacarbazine_Interferon-Alfa_Interleukin-2_Vinblastine"                                                                                                      
[10502] "Homoharringtonine_Interferon-Alfa"                                                                                                                                    
[10503] "Filgrastim_Fluorouracil_Hydroxyurea_Interferon-Alfa"                                                                                                                  
[10504] "Cisplatin_Dacarbazine_Interferon-Alfa_Interleukin-2_Tamoxifen_Tumor-Infiltrating-Lymphocytes"                                                                         
[10505] "Epoetin-Alfa_Interleukin-6_Sargramostim"                                                                                                                              
[10506] "Interferon-Alfa_Interleukin-2_Tamoxifen"                                                                                                                              
[10507] "Fluorouracil_Interferon-Alfa_Leucovorin-Calcium_Raltitrexed"                                                                                                          
[10508] "Carmustine_Cisplatin_Dacarbazine_Interferon-Alfa_Interleukin-2_Tamoxifen"                                                                                             
[10509] "Etoposide_Fluorouracil_Interferon-Alfa_Leucovorin-Calcium"                                                                                                            
[10510] "Interferon-Alfa_Interleukin-2_Isotretinoin"                                                                                                                           
[10511] "Fluorouracil_Interferon-Alfa_Interleukin-2_Isotretinoin"                                                                                                              
[10512] "Cyclophosphamide_Interleukin-2_Monoclonal-Antibody-OKT3_Tumor-Necrosis-Factor"                                                                                        
[10513] "Cyclophosphamide_Interleukin-2_Monoclonal-Antibody-OKT3"                                                                                                              
[10514] "Bleomycin_Dacarbazine_Lomustine_Vincristine"                                                                                                                          
[10515] "Bleomycin_Dacarbazine_Interferon-Alfa_Lomustine_Vincristine"                                                                                                          
[10516] "Interleukin-2_Zinc-Oxide"                                                                                                                                             
[10517] "Cisplatin_Dacarbazine_Interferon-Alfa_Interleukin-2"                                                                                                                  
[10518] "Cisplatin_Dacarbazine_Interferon-Alfa"                                                                                                                                
[10519] "Cyclophosphamide_Cytarabine_Thioguanine_Vincristine"                                                                                                                  
[10520] "Cyclophosphamide_Daunorubicin_Pegaspargase_Prednisone_Vincristine"                                                                                                    
[10521] "Cyclophosphamide_Cytarabine_Mercaptopurine_Pegaspargase_Vincristine"                                                                                                  
[10522] "Etoposide_Mitoxantrone_Tretinoin-Liposome"                                                                                                                            
[10523] "Cytarabine_Tretinoin-Liposome"                                                                                                                                        
[10524] "Ketoconazole_Tretinoin"                                                                                                                                               
[10525] "Disulfiram_Tretinoin"                                                                                                                                                 
[10526] "Carmustine_Cytarabine_Methotrexate_Vincristine"                                                                                                                       
[10527] "Human-Chorionic-Gonadotropin_Staphage-Lysate"                                                                                                                         
[10528] "Cisplatin_Fluorouracil_L-Leucovorin"                                                                                                                                  
[10529] "Dexamethasone_Melphalan"                                                                                                                                              
[10530] "Cyclophosphamide_Filgrastim_Paclitaxel"                                                                                                                               
[10531] "Cyclophosphamide_Paclitaxel_Sargramostim"                                                                                                                             
[10532] "Busulfan_Dexamethasone_Thiotepa"                                                                                                                                      
[10533] "Cyclosporine_Methylprednisolone"                                                                                                                                      
[10534] "Dexamethasone_Doxorubicin_Pegaspargase_Vincristine"                                                                                                                   
[10535] "Dexamethasone_Pegaspargase_Vincristine"                                                                                                                               
[10536] "Carmustine_Cytarabine_Etoposide_Melphalan"                                                                                                                            
[10537] "Idarubicin_Tretinoin-Liposome"                                                                                                                                        
[10538] "Docetaxel_Vinorelbine"                                                                                                                                                
[10539] "Docetaxel_Filgrastim_Vinorelbine"                                                                                                                                     
[10540] "Floxuridine_Gemcitabine_Leucovorin-Calcium"                                                                                                                           
[10541] "Filgrastim_Losoxantrone_Paclitaxel"                                                                                                                                   
[10542] "Cyclophosphamide_Daunorubicin_Dexamethasone_Vincristine"                                                                                                              
[10543] "Cytarabine_Idarubicin_Thioguanine"                                                                                                                                    
[10544] "Interferon-Alfa_Interleukin-2_Paclitaxel"                                                                                                                             
[10545] "Mercaptopurine_Methotrexate_Tretinoin"                                                                                                                                
[10546] "Carboplatin_Cisplatin_Interferon-Alfa_Interleukin-2_Paclitaxel"                                                                                                       
[10547] "Interleukin-2_Melatonin"                                                                                                                                              
[10548] "Paclitaxel_Vinorelbine"                                                                                                                                               
[10549] "Asparaginase_Cyclophosphamide_Cytarabine_Etoposide_Mercaptopurine_Methotrexate"                                                                                       
[10550] "Cisplatin_gemcitabine"                                                                                                                                                
[10551] "Carboplatin_RMP-7"                                                                                                                                                    
[10552] "Epirubicin_Vinorelbine"                                                                                                                                               
[10553] "Allovectin-7_Interleukin-2"                                                                                                                                           
[10554] "Cyclophosphamide_Losoxantrone"                                                                                                                                        
[10555] "Doxorubicin_Losoxantrone"                                                                                                                                             
[10556] "Cyclophosphamide_Daunorubicin"                                                                                                                                        
[10557] "Asparaginase_Cytarabine_Methotrexate"                                                                                                                                 
[10558] "Daunorubicin_Dexamethasone"                                                                                                                                           
[10559] "Fluorouracil_Octreotide-Pamoate"                                                                                                                                      
[10560] "_9-cis-Retinoic-Acid_Tamoxifen"                                                                                                                                       
[10561] "Dexrazoxane_Doxorubicin_Paclitaxel"                                                                                                                                   
[10562] "Dexrazoxane_Doxorubicin_Filgrastim_Paclitaxel"                                                                                                                        
[10563] "Amsacrine_Carmustine_Cytarabine_Etoposide"                                                                                                                            
[10564] "Cyclophosphamide_Etoposide_Mitoxantrone"                                                                                                                              
[10565] "Fluorouracil_Leucovorin-Calcium_Topotecan"                                                                                                                            
[10566] "Carmustine_Etoposide"                                                                                                                                                 
[10567] "Letrozole_Tamoxifen"                                                                                                                                                  
[10568] "Cyclosporine_Prednisone"                                                                                                                                              
[10569] "Doxorubicin_Estramustine"                                                                                                                                             
[10570] "Etoposide_Ifosfamide_Mesna_Mitoxantrone"                                                                                                                              
[10571] "Interferon-Gamma_Monoclonal-Antibody-CC49"                                                                                                                            
[10572] "Cyclosporine_Cytarabine_Daunorubicin_Etoposide"                                                                                                                       
[10573] "Cyclosporine_Cytarabine_Etoposide_Idarubicin"                                                                                                                         
[10574] "Asparaginase_Dexrazoxane_Doxorubicin_Mercaptopurine_Prednisone_Vincristine"                                                                                           
[10575] "Asparaginase_Dexrazoxane_Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                              
[10576] "Asparaginase_Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                                          
[10577] "Dexrazoxane_Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine"                                                                                           
[10578] "Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Pegaspargase_Thioguanine_Vincristine"                                                                           
[10579] "Methotrexate_Pegaspargase_Vincristine"                                                                                                                                
[10580] "Mercaptopurine_Vincristine"                                                                                                                                           
[10581] "Estramustine_Strontium-Chloride-Sr-89_Vinblastine"                                                                                                                    
[10582] "AG337_Cisplatin"                                                                                                                                                      
[10583] "Cyclophosphamide_Cytarabine_Daunorubicin_Dexamethasone_Vincristine"                                                                                                   
[10584] "Cyclophosphamide_Cytarabine_Methylprednisolone"                                                                                                                       
[10585] "Hydrocortisone_Methotrexate"                                                                                                                                          
[10586] "Asparaginase_Dexamethasone_Epirubicin_Vincristine"                                                                                                                    
[10587] "Cytarabine_Etoposide_Vincristine"                                                                                                                                     
[10588] "Cytarabine_Etoposide_Thioguanine_Vincristine"                                                                                                                         
[10589] "Asparaginase_Cyclophosphamide_Cytarabine_Dexamethasone_Epirubicin_Etoposide_Thioguanine_Vincristine"                                                                  
[10590] "Cyclophosphamide_Cytarabine_Etoposide_Mercaptopurine_Methotrexate_Prednisolone_Thioguanine_Vincristine"                                                               
[10591] "Carboplatin_Filgrastim"                                                                                                                                               
[10592] "Cimetidine_Tumor-Infiltrating-Lymphocytes"                                                                                                                            
[10593] "Asparaginase_Cyclophosphamide_Daunorubicin_Dexamethasone_Vincristine"                                                                                                 
[10594] "GM2-KLH-Vaccine_Interferon-Alfa"                                                                                                                                      
[10595] "Cisplatin_Fluorouracil_Tirapazamine"                                                                                                                                  
[10596] "Cytarabine_Etoposide_Methotrexate_Pegaspargase_Prednisone_Thioguanine_Vincristine"                                                                                    
[10597] "Asparaginase_Prednisolone_Vincristine"                                                                                                                                
[10598] "Mercaptopurine_Prednisolone_Vincristine"                                                                                                                              
[10599] "Fludarabine_Octreotide"                                                                                                                                               
[10600] "Cytarabine_Hydroxyurea_Interferon-Alfa"                                                                                                                               
[10601] "BCG_Dacarbazine"                                                                                                                                                      
[10602] "Amifostine_Paclitaxel"                                                                                                                                                
[10603] "Cisplatin_Isotretinoin"                                                                                                                                               
[10604] "Cyclophosphamide_Cyclosporine_Cytarabine_Daunorubicin"                                                                                                                
[10605] "Cyclophosphamide_Etoposide_Mitoxantrone_Pegaspargase_Prednisone_Vincristine"                                                                                          
[10606] "Suramin_Topotecan"                                                                                                                                                    
[10607] "Doxorubicin_VX-710"                                                                                                                                                   
[10608] "Cyclosporine_Interferon-Gamma_Interleukin-2"                                                                                                                          
[10609] "Carmustine_Interferon-Alfa_Tamoxifen"                                                                                                                                 
[10610] "Bleomycin_Carboplatin_Cisplatin_Vincristine"                                                                                                                          
[10611] "Cyclophosphamide_Dexamethasone_Etoposide_Mercaptopurine_Methotrexate_Vincristine"                                                                                     
[10612] "Dacarbazine_Doxorubicin_Ifosfamide_Mesna"                                                                                                                             
[10613] "Cyclosporine_Methylprednisolone_Prednisone"                                                                                                                           
[10614] "Cyclophosphamide_Cytarabine_Daunorubicin"                                                                                                                             
[10615] "Cisplatin_Interleukin-2_Paclitaxel_Tumor-Infiltrating-Lymphocytes"                                                                                                    
[10616] "Carboplatin_Paclitaxel_Topotecan"                                                                                                                                     
[10617] "Carboplatin_Filgrastim_Paclitaxel_Topotecan"                                                                                                                          
[10618] "P-30-protein_Tamoxifen"                                                                                                                                               
[10619] "Cladribine_Etoposide"                                                                                                                                                 
[10620] "Prednisone_Tacrolimus"                                                                                                                                                
[10621] "Fluorouracil_Phenylbutyrate"                                                                                                                                          
[10622] "Etoposide_Methylprednisolone"                                                                                                                                         
[10623] "Melphalan_Mitoxantrone"                                                                                                                                               
[10624] "Carboplatin_Etoposide_Paclitaxel"                                                                                                                                     
[10625] "Carboplatin_Cyclosporine_Doxorubicin"                                                                                                                                 
[10626] "Cytarabine_Deoxycytidine"                                                                                                                                             
[10627] "Octreotide-Pamoate_Tamoxifen"                                                                                                                                         
[10628] "Carboplatin_9-cis-Retinoic-Acid"                                                                                                                                      
[10629] "Bleomycin_Dexrazoxane_Doxorubicin_Etoposide_Vincristine"                                                                                                              
[10630] "Fluorouracil_Leucovorin-Calcium_Oxaliplatin"                                                                                                                          
[10631] "Fluorouracil_Gemcitabine"                                                                                                                                             
[10632] "Carboplatin_Cyclosporine_Dipyridamole_Etoposide_Prochlorperazine"                                                                                                     
[10633] "Carboplatin_Cyclosporine_Interferon-Alfa"                                                                                                                             
[10634] "Cisplatin_Toremifene"                                                                                                                                                 
[10635] "Dexamethasone_Etoposide_Ifosfamide_Pegaspargase_Vincristine"                                                                                                          
[10636] "Dexamethasone_Methotrexate_Pegaspargase_Vincristine"                                                                                                                  
[10637] "Cyclophosphamide_Dexamethasone_Idarubicin_Pegaspargase_Vincristine"                                                                                                   
[10638] "Cytarabine_Pegaspargase_Thioguanine_Vincristine"                                                                                                                      
[10639] "Pegaspargase_Vincristine"                                                                                                                                             
[10640] "Carboplatin_Ifosfamide_Paclitaxel"                                                                                                                                    
[10641] "Carboplatin_Cyclophosphamide_Cyclosporine_Paclitaxel"                                                                                                                 
[10642] "Cisplatin_Cyclophosphamide_Cyclosporine_Paclitaxel"                                                                                                                   
[10643] "Docetaxel_Epirubicin"                                                                                                                                                 
[10644] "Docetaxel_Epirubicin_Filgrastim"                                                                                                                                      
[10645] "Dronabinol_Megestrol"                                                                                                                                                 
[10646] "Cisplatin_Doxorubicin_Edatrexate_Filgrastim_Vinblastine"                                                                                                              
[10647] "Doxorubicin_PSC-833"                                                                                                                                                  
[10648] "Cyclophosphamide_Melphalan_Mitoxantrone"                                                                                                                              
[10649] "Aminoglutethimide_Bicalutamide_Hydrocortisone"                                                                                                                        
[10650] "Aminoglutethimide_Hydrocortisone"                                                                                                                                     
[10651] "Docetaxel_Doxorubicin"                                                                                                                                                
[10652] "Cisplatin_Doxorubicin_Ifosfamide_Mitomycin"                                                                                                                           
[10653] "Cisplatin_Doxorubicin_Ifosfamide_Mitomycin_sargramostim"                                                                                                              
[10654] "Doxorubicin_DPPE"                                                                                                                                                     
[10655] "Dacarbazine_Doxorubicin_Ifosfamide_Vincristine"                                                                                                                       
[10656] "Dexamethasone_Doxorubicin_PSC-833_Vincristine"                                                                                                                        
[10657] "Cyclosporine_Methotrexate_Sirolimus"                                                                                                                                  
[10658] "Interferon-Gamma_Interleukin-1-Beta_Interleukin-2_Sargramostim_Tumor-Necrosis-Factor"                                                                                 
[10659] "Cyclophosphamide_Indomethacin_Zinc-Sulfate"                                                                                                                           
[10660] "Cisplatin_Hydroxyurea_Vinblastine"                                                                                                                                    
[10661] "Cisplatin_Etoposide_Hydroxyurea"                                                                                                                                      
[10662] "Cisplatin_Hydroxyurea_vinorelbine"                                                                                                                                    
[10663] "Cisplatin_Hydroxyurea_Vindesine"                                                                                                                                      
[10664] "Cisplatin_Hydroxyurea"                                                                                                                                                
[10665] "Carboplatin_Epirubicin_Vincristine"                                                                                                                                   
[10666] "gp100-Antigen_MART-1-Antigen"                                                                                                                                         
[10667] "Bryostatin-1_Vincristine"                                                                                                                                             
[10668] "Doxorubicin_Progesterone"                                                                                                                                             
[10669] "Cyclophosphamide_Doxorubicin_Filgrastim_Paclitaxel"                                                                                                                   
[10670] "Irinotecan_Raltitrexed"                                                                                                                                               
[10671] "Cisplatin_filgrastim_Paclitaxel_topotecan"                                                                                                                            
[10672] "Cisplatin_Paclitaxel_Topotecan"                                                                                                                                       
[10673] "Chlorodihydroxypyridine_Potassium-Oxonate_Tegafur"                                                                                                                    
[10674] "Bleomycin_Cyclophosphamide_Idarubicin_Methylprednisolone_Methotrexate_Vincristine"                                                                                    
[10675] "Methotrexate_Tacrolimus"                                                                                                                                              
[10676] "Indinavir_Lamivudine_Stavudine"                                                                                                                                       
[10677] "Cyclophosphamide_Doxorubicin_Prednisone_Sargramostim_Vincristine"                                                                                                     
[10678] "Carboplatin_Cyclophosphamide_Etoposide_filgrastim_Paclitaxel"                                                                                                         
[10679] "Cyclophosphamide_Epirubicin_Filgrastim_Fluorouracil"                                                                                                                  
[10680] "Irinotecan_Paclitaxel"                                                                                                                                                
[10681] "Cisplatin_Mitomycin_Vincristine"                                                                                                                                      
[10682] "Lomustine_Procarbazine_Thioguanine_Vincristine"                                                                                                                       
[10683] "Cyclophosphamide_Doxorubicin_Prednisone_Rituximab_Vincristine"                                                                                                        
[10684] "Carmustine_Cyclophosphamide_Etoposide_Mesna"                                                                                                                          
[10685] "Ethynyluracil_Fluorouracil"                                                                                                                                           
[10686] "Ethynyluracil_Fluorouracil_Leucovorin-Calcium"                                                                                                                        
[10687] "Epirubicin_Paclitaxel"                                                                                                                                                
[10688] "Dexamethasone_Fludarabine_Mitoxantrone"                                                                                                                               
[10689] "Paclitaxel_VX-710"                                                                                                                                                    
[10690] "Docetaxel_Estramustine_Hydrocortisone"                                                                                                                                
[10691] "Busulfan_Cyclophosphamide_Decitabine"                                                                                                                                 
[10692] "Cladribine_Cytarabine"                                                                                                                                                
[10693] "Cisplatin_Ifosfamide_Mesna_Mitomycin"                                                                                                                                 
[10694] "Anti-Thymocyte-Globulin_Melphalan"                                                                                                                                    
[10695] "Carmustine_Cisplatin_filgrastim_Thiotepa"                                                                                                                             
[10696] "Cyclophosphamide_Dexamethasone_Etoposide"                                                                                                                             
[10697] "Fluorouracil_Marimastat"                                                                                                                                              
[10698] "Cytarabine_Lomustine_Methotrexate_Methylprednisolone_Procarbazine"                                                                                                    
[10699] "Etoposide_Ifosfamide_Mesna"                                                                                                                                           
[10700] "Ifosfamide_Mesna_Mitoxantrone"                                                                                                                                        
[10701] "Cyclophosphamide_Doxorubicin_Octreotide-Pamoate_Tamoxifen"                                                                                                            
[10702] "Cyclophosphamide_Filgrastim_Vincristine"                                                                                                                              
[10703] "Carboplatin_Ifosfamide_Mesna"                                                                                                                                         
[10704] "Carboplatin_Filgrastim_Ifosfamide_Mesna"                                                                                                                              
[10705] "Cisplatin_Paclitaxel_Tirapazamine"                                                                                                                                    
[10706] "Carmustine_Topotecan"                                                                                                                                                 
[10707] "Carmustine_Irinotecan"                                                                                                                                                
[10708] "Bleomycin_Cyclophosphamide_Doxorubicin_Etoposide_Prednisolone_Vincristine"                                                                                            
[10709] "Interferon-Alfa_Ritonavir_Stavudine"                                                                                                                                  
[10710] "Cordycepin_Pentostatin"                                                                                                                                               
[10711] "Flavopiridol_Paclitaxel"                                                                                                                                              
[10712] "Bleomycin_Doxorubicin_Vindesine"                                                                                                                                      
[10713] "Fluorouracil-Uracil"                                                                                                                                                  
[10714] "Fluorouracil_Hydroxyurea_Paclitaxel"                                                                                                                                  
[10715] "Epoetin-Alfa_Fluorouracil_Hydroxyurea_Paclitaxel"                                                                                                                     
[10716] "Cisplatin_Docetaxel_Gemcitabine"                                                                                                                                      
[10717] "Cytarabine_Etoposide_Mitoxantrone_PSC-833"                                                                                                                            
[10718] "Carboplatin_Estramustine_Paclitaxel"                                                                                                                                  
[10719] "Amifostine_Cisplatin_Paclitaxel"                                                                                                                                      
[10720] "Amifostine_Carboplatin_Paclitaxel"                                                                                                                                    
[10721] "Amifostine_Topotecan"                                                                                                                                                 
[10722] "Marimastat_Tamoxifen"                                                                                                                                                 
[10723] "Amifostine_Cisplatin_Fluorouracil"                                                                                                                                    
[10724] "Doxorubicin-HCl-Liposome_VX-853"                                                                                                                                      
[10725] "Cyclophosphamide_Doxorubicin_Marimastat"                                                                                                                              
[10726] "Floxuridine_Leucovorin-Calcium_Melphalan"                                                                                                                             
[10727] "Etoposide_Ifosfamide_Mesna_Topotecan"                                                                                                                                 
[10728] "Etoposide-Phosphate_Topotecan"                                                                                                                                        
[10729] "Doxorubicin_Etoposide_Ifosfamide"                                                                                                                                     
[10730] "Doxorubicin_Raltitrexed"                                                                                                                                              
[10731] "Anti-Thymocyte-Globulin_Cyclophosphamide"                                                                                                                             
[10732] "Estramustine_Etoposide_Paclitaxel"                                                                                                                                    
[10733] "Doxorubicin_Estramustine_Ketoconazole_Vinblastine"                                                                                                                    
[10734] "Amifostine_Ciprofloxacin_Pentoxifylline"                                                                                                                              
[10735] "Amifostine_Ciprofloxacin_Dexamethasone_Pentoxifylline"                                                                                                                
[10736] "Docetaxel_Estramustine"                                                                                                                                               
[10737] "Oltipraz_Vitamin-A"                                                                                                                                                   
[10738] "Fenretinide_Vitamin-A"                                                                                                                                                
[10739] "Calcium-Carbonate_Cholecalciferol"                                                                                                                                    
[10740] "Bryostatin-1_Cytarabine"                                                                                                                                              
[10741] "Amifostine_Cyclophosphamide_Mitoxantrone_Thiotepa"                                                                                                                    
[10742] "Fluorouracil_Raltitrexed"                                                                                                                                             
[10743] "Bryostatin-1_Cisplatin"                                                                                                                                               
[10744] "Carboplatin_Cyclophosphamide_Doxorubicin"                                                                                                                             
[10745] "Doxorubicin_Gemcitabine"                                                                                                                                              
[10746] "Fluorouracil_Gemcitabine_Leucovorin-Calcium"                                                                                                                          
[10747] "Cyclophosphamide_Etoposide_Lomustine_Procarbazine"                                                                                                                    
[10748] "Bacitracin_Clotrimazole_Gentamicin"                                                                                                                                   
[10749] "AUT-OV-ALVAC-hB7-1_Interferon-Gamma"                                                                                                                                  
[10750] "Gemcitabine_Irinotecan"                                                                                                                                               
[10751] "Amifostine_Carboplatin_Cyclophosphamide"                                                                                                                              
[10752] "Cyclosporine_Mycophenolate-Mofetil"                                                                                                                                   
[10753] "gp100-Antigen_Incomplete-Freunds-Adjuvant_MART-1Antigen_sargramostim_Tyrosinase-Peptide"                                                                              
[10754] "Bismuth-Subcitrate_Metronidazole_Omeprazole_Tetracycline"                                                                                                             
[10755] "Amoxicillin_Clarithromycin_Omeprazole"                                                                                                                                
[10756] "Incomplete-Freunds-Adjuvant_Interleukin-2_Tyrosinase-Peptide"                                                                                                         
[10757] "gp100-Antigen_Incomplete-Freunds-Adjuvant_Sargramostim"                                                                                                               
[10758] "Incomplete-Freunds-Adjuvant_Sargramostim_Tyrosinase-Peptide"                                                                                                          
[10759] "Incomplete-Freunds-Adjuvant_Interleukin-12_Tyrosinase-Peptide"                                                                                                        
[10760] "Incomplete-Freunds-Adjuvant_Interleukin-2_Tyrosinase-Related-Protein-1"                                                                                               
[10761] "Incomplete-Freunds-Adjuvant_Sargramostim_Tyrosinase-Related-Protein-1"                                                                                                
[10762] "Carboplatin_Cisplatin_Floxuridine"                                                                                                                                    
[10763] "Carboplatin_Floxuridine"                                                                                                                                              
[10764] "Cisplatin_Floxuridine"                                                                                                                                                
[10765] "Amifostine_Cisplatin_Gemcitabine"                                                                                                                                     
[10766] "Bryostatin-1_Cladribine"                                                                                                                                              
[10767] "Cladribine_Idarubicin"                                                                                                                                                
[10768] "Buserelin_Flutamide"                                                                                                                                                  
[10769] "Buserelin_Nilutamide"                                                                                                                                                 
[10770] "Bicalutamide_Buserelin"                                                                                                                                               
[10771] "Leuprolide_Nilutamide"                                                                                                                                                
[10772] "Histamine-Dihydrochloride_Interleukin-2"                                                                                                                              
[10773] "Carboplatin_Etoposide_Fluorouracil"                                                                                                                                   
[10774] "Amifostine_Fludarabine"                                                                                                                                               
[10775] "Flt3-Ligand_gp100-Antigen"                                                                                                                                            
[10776] "Bleomycin_Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Vincristine"                                                                                              
[10777] "Bleomycin_Cyclophosphamide_dexrazoxane_Doxorubicin_Etoposide_Prednisone_Vincristine"                                                                                  
[10778] "Doxorubicin-HCl-Liposome_PSC-833"                                                                                                                                     
[10779] "Amifostine_Busulfan_Melphalan_Thiotepa"                                                                                                                               
[10780] "Ifosfamide_Topotecan"                                                                                                                                                 
[10781] "Cytarabine_Daunorubicin_Etoposide_PSC-833"                                                                                                                            
[10782] "Mitoxantrone_Vinorelbine"                                                                                                                                             
[10783] "Docetaxel_Fluorouracil"                                                                                                                                               
[10784] "Carboplatin_Thiotepa_Topotecan"                                                                                                                                       
[10785] "Amifostine_Cisplatin_Cytarabine_Dexamethasone"                                                                                                                        
[10786] "Interleukin-2_Sargramostim_Vinblastine"                                                                                                                               
[10787] "Peptide-946-Melanoma-Vaccine_QS21"                                                                                                                                    
[10788] "Peptide-946-Melanoma-Vaccine_QS21_Tetanus-Peptide-Melanoma-Vaccine"                                                                                                   
[10789] "Interleukin-2_Monoclonal-Antibody-3622W94_Sargramostim"                                                                                                               
[10790] "Interleukin-2_Monoclonal-Antibody-3622W94"                                                                                                                            
[10791] "ALVAC-CEA-Vaccine_Sargramostim"                                                                                                                                       
[10792] "Amifostine_Irinotecan"                                                                                                                                                
[10793] "Dexamethasone_Metoclopramide"                                                                                                                                         
[10794] "Dexamethasone_Granisetron"                                                                                                                                            
[10795] "Bryostatin-1_Paclitaxel"                                                                                                                                              
[10796] "Interferon-Alfa_Isotretinoin_Vitamin-E"                                                                                                                               
[10797] "Cytarabine_Homoharringtonine_Interferon-Alfa"                                                                                                                         
[10798] "Leucovorin-Calcium_Methotrexate_Vincristine"                                                                                                                          
[10799] "Clodronate_Mitoxantrone_Prednisone"                                                                                                                                   
[10800] "Mitoxantrone_Prednisone"                                                                                                                                              
[10801] "Cladribine_Cyclophosphamide_Prednisone"                                                                                                                               
[10802] "Cytarabine_Cyclophosphamide_Dexamethasone_Doxorubicin_Methotrexate_Vincristine"                                                                                       
[10803] "Interferon-Alfa_Ritonavir"                                                                                                                                            
[10804] "Fludarabine_Rituximab"                                                                                                                                                
[10805] "Cyclophosphamide_Mercaptopurine_Methotrexate"                                                                                                                         
[10806] "Carboxyamidotriazole_Ketoconazole"                                                                                                                                    
[10807] "Mycophenolate-Mofetil_Tacrolimus"                                                                                                                                     
[10808] "Omeprazole_Porfimer-Sodium"                                                                                                                                           
[10809] "Cisplatin_docetaxel_Fluorouracil"                                                                                                                                     
[10810] "Amifostine_Cisplatin_Cyclophosphamide_Etoposide"                                                                                                                      
[10811] "Cyproterone_Luteinizing-Hormone-Releasing-Factor"                                                                                                                     
[10812] "Octreotide_Prednisone"                                                                                                                                                
[10813] "Carboplatin_Estramustine_Filgrastim_Paclitaxel"                                                                                                                       
[10814] "BCG_Monoclonal-Antibody-BEC2"                                                                                                                                         
[10815] "Cyclophosphamide_Tirapazamine"                                                                                                                                        
[10816] "Amifostine_Cytarabine_Idarubicin"                                                                                                                                     
[10817] "Fluorouracil_Trimetrexate-Glucuronate"                                                                                                                                
[10818] "Cisplatin_Fluorouracil_ONYX-015"                                                                                                                                      
[10819] "Mitoxantrone_Thiotepa_Topotecan"                                                                                                                                      
[10820] "Amifostine_Carboplatin_Filgrastim_Paclitaxel"                                                                                                                         
[10821] "Cytarabine_Daunorubicin_Interleukin-11_Sargramostim"                                                                                                                  
[10822] "Interleukin-11_Sargramostim"                                                                                                                                          
[10823] "gp100-Antigen_Tyrosinase-Peptide"                                                                                                                                     
[10824] "Bryostatin-1_Interleukin-2_Lonomycin"                                                                                                                                 
[10825] "Finasteride_Flutamide"                                                                                                                                                
[10826] "Cyclophosphamide_DPPE"                                                                                                                                                
[10827] "Busulfan_Cyclophosphamide_Anti-Thymocyte-Globulin"                                                                                                                    
[10828] "Cyclophosphamide_Methylprednisolone"                                                                                                                                  
[10829] "Busulfan_Cyclophosphamide_Methylprednisolone"                                                                                                                         
[10830] "AG3340_Carboplatin_Paclitaxel"                                                                                                                                        
[10831] "Docetaxel_Doxorubicin-HCl-Liposome"                                                                                                                                   
[10832] "Carboplatin_Lomustine_Procarbazine_Vincristine"                                                                                                                       
[10833] "Cisplatin_Cyclophosphamide_Etoposide_Leucovorin-calcium_Methotrexate_Vincristine"                                                                                     
[10834] "Doxorubicin-HCl-Liposome_Paclitaxel"                                                                                                                                  
[10835] "Carboplatin_Thalidomide"                                                                                                                                              
[10836] "Filgrastim_Pegylated-Recombinant-Human-Megakaryocyte-Growth-and-Development-Factor"                                                                                   
[10837] "gp100-Antigen_Incomplete-Freunds-Adjuvant_Interleukin-12_Tyrosinase-Peptide"                                                                                          
[10838] "gp100-Antigen_Incomplete-Freunds-Adjuvant_Tyrosinase-Peptide"                                                                                                         
[10839] "Acetaminophen_Acetylcysteine_Carmustine"                                                                                                                              
[10840] "Acetaminophen_Acetylcysteine"                                                                                                                                         
[10841] "Filgrastim_Promegapoietin"                                                                                                                                            
[10842] "Doxorubicin-HCl-Liposome_Topotecan"                                                                                                                                   
[10843] "Ciprofloxacin_Dexamethasone_Pentoxifylline"                                                                                                                           
[10844] "Cisplatin_LY231514"                                                                                                                                                   
[10845] "Etoposide_Gemcitabine"                                                                                                                                                
[10846] "Carboplatin_Doxorubicin-HCl-Liposome_Paclitaxel"                                                                                                                      
[10847] "Carboplatin_Gemcitabine_Paclitaxel"                                                                                                                                   
[10848] "gp100-Antigen_Sargramostim_Tyrosinase-Peptide"                                                                                                                        
[10849] "Fluorouracil_Paclitaxel"                                                                                                                                              
[10850] "Bryostatin-1_Fludarabine"                                                                                                                                             
[10851] "BMS-182751_Prednisone"                                                                                                                                                
[10852] "Doxorubicin-HCl-Liposome_Etoposide"                                                                                                                                   
[10853] "Anti-Thymocyte-Globulin_Busulfan_Melphalan"                                                                                                                           
[10854] "Busulfan_Melphalan_Methylprednisolone"                                                                                                                                
[10855] "Interleukin-2_Rituximab"                                                                                                                                              
[10856] "Amifostine_Cytarabine_Mitoxantrone"                                                                                                                                   
[10857] "Gemcitabine_Topotecan"                                                                                                                                                
[10858] "Cyclophosphamide_Docetaxel_Doxorubicin"                                                                                                                               
[10859] "Cyclophosphamide_Doxorubicin-HCl-Liposome_Prednisone_Vincristine"                                                                                                     
[10860] "Cyclophosphamide_Daunorubicin_Prednisone_Vincristine"                                                                                                                 
[10861] "Incomplete-Freunds-Adjuvant_Peptide-946-Melanoma-Vaccine"                                                                                                             
[10862] "Carmustine_Melphalan"                                                                                                                                                 
[10863] "Gemcitabine_Paclitaxel"                                                                                                                                               
[10864] "Chlorambucil_Doxorubicin_Etoposide_Prednisolone_Procarbazine_Vinblastine_Vincristine"                                                                                 
[10865] "Gemcitabine_Vinorelbine"                                                                                                                                              
[10866] "Cytarabine_Daunorubicin_Etoposide_Methotrexate_Prednisolone_Thioguanine_Vincristine"                                                                                  
[10867] "Cyclophosphamide_Cytarabine_Methotrexate_Thioguanine"                                                                                                                 
[10868] "BAY-12-9566_Doxorubicin"                                                                                                                                              
[10869] "BAY-12-9566_Fluorouracil_Leucovorin-Calcium"                                                                                                                          
[10870] "Asparaginase_Methotrexate_Prednisolone_Vincristine"                                                                                                                   
[10871] "Interferon-Alfa_Interleukin-12"                                                                                                                                       
[10872] "Carcinoembryonic-Antigen-Peptide-1_Hepatitis-B-Antigen-Peptide"                                                                                                       
[10873] "Carmustine_Gemcitabine_Melphalan"                                                                                                                                     
[10874] "Cisplatin_Cyclophosphamide_Dexamethasone_Etoposide_Gemcitabine"                                                                                                       
[10875] "Irinotecan_Oxaliplatin"                                                                                                                                               
[10876] "Cisplatin_Floxuridine_Paclitaxel"                                                                                                                                     
[10877] "Cisplatin_Cyclophosphamide_Dexamethasone_Etoposide"                                                                                                                   
[10878] "Interferon-Alfa_Interleukin-2_Sargramostim"                                                                                                                           
[10879] "Amifostine_Epoetin-Alfa"                                                                                                                                              
[10880] "Incomplete-Freunds-Adjuvant_Von-Hippel-Lindau-Peptide-Vaccine"                                                                                                        
[10881] "Incomplete-Freunds-Adjuvant_Sargramostim_Von-Hippel-Lindau-Peptide-Vaccine"                                                                                           
[10882] "Carmustine_Fluorouracil_Streptozocin_Vincristine"                                                                                                                     
[10883] "Adenovirus-5-CD40-L-Vector_Interleukin-2"                                                                                                                             
[10884] "Cyclophosphamide_Prednisone_Sargramostim_Vincristine"                                                                                                                 
[10885] "Isotretinoin_Procarbazine"                                                                                                                                            
[10886] "Anti-Thymocyte-Globulin_Cyclophosphamide_Fludarabine"                                                                                                                 
[10887] "Dexamethasone_Methotrexate_Thioguanine_Vincristine"                                                                                                                   
[10888] "Methotrexate_Prednisolone_Thioguanine_Vincristine"                                                                                                                    
[10889] "Flt3-Ligand_gp100-Antigen_MART-1-Antigen_Tyrosinase"                                                                                                                  
[10890] "Flt3-Ligand_gp100-Antigen_Incomplete-Freunds-Adjuvant_MART-1Antigen_Tyrosinase"                                                                                       
[10891] "Carboplatin_Docetaxel"                                                                                                                                                
[10892] "Cisplatin_Dexamethasone_Paclitaxel"                                                                                                                                   
[10893] "Cisplatin_Cyclophosphamide_Epirubicin_Etoposide"                                                                                                                      
[10894] "Interferon-Alfa_Sargramostim"                                                                                                                                         
[10895] "Cisplatin_Dimesna_Paclitaxel"                                                                                                                                         
[10896] "Etoposide_Idarubicin"                                                                                                                                                 
[10897] "Cytarabine_Idarubicin_Recombinant-Human-Thrombopoietin"                                                                                                               
[10898] "Cyclophosphamide_Cytarabine_Hydrocortisone_Leucovorin-Calcium"                                                                                                        
[10899] "Fenretinide_Tretinoin"                                                                                                                                                
[10900] "Melphalan_Prednisolone"                                                                                                                                               
[10901] "Dexamethasone_Idarubicin_Lomustine"                                                                                                                                   
[10902] "Carboplatin_Gemcitabine"                                                                                                                                              
[10903] "Filgrastim_Sargramostim"                                                                                                                                              
[10904] "gp209-2M-Antigen_Incomplete-Freunds-Adjuvant_Interleukin-2"                                                                                                           
[10905] "Cyclophosphamide_Rituximab"                                                                                                                                           
[10906] "Docetaxel_Estramustine_Mitoxantrone_Prednisone"                                                                                                                       
[10907] "Cyclosporine_Etoposide_Vincristine"                                                                                                                                   
[10908] "Bleomycin_Cisplatin_Etoposide_Paclitaxel"                                                                                                                             
[10909] "Cytarabine_Fludarabine_Topotecan"                                                                                                                                     
[10910] "Chlorambucil_Dexamethasone_Idarubicin"                                                                                                                                
[10911] "Chlorambucil_Dexamethasone"                                                                                                                                           
[10912] "Cytarabine_Etoposide_Melphalan"                                                                                                                                       
[10913] "Cytarabine_Daunorubicin_Filgrastim"                                                                                                                                   
[10914] "Antineoplaston-A10_Methotrexate"                                                                                                                                      
[10915] "Cyclophosphamide_THERATOPE-STn-KLH-Vaccine"                                                                                                                           
[10916] "Fluorouracil_Gemcitabine_Interferon-Alfa_Interleukin-2"                                                                                                               
[10917] "Interferon-Alfa_Tretinoin-Liposome"                                                                                                                                   
[10918] "Doxorubicin_Methylprednisolone"                                                                                                                                       
[10919] "Clarithromycin_Omeprazole_Tinidazole"                                                                                                                                 
[10920] "Cyclophosphamide_Pentostatin"                                                                                                                                         
[10921] "Phenylbutyrate_Tretinoin"                                                                                                                                             
[10922] "Asparaginase_Dexamethasone_Mercaptopurine_Vincristine"                                                                                                                
[10923] "Asparaginase_Daunorubicin_Dexamethasone_Vincristine"                                                                                                                  
[10924] "Dexamethasone_Leucovorin-Calcium_Mercaptopurine_Methotrexate_Vincristine"                                                                                             
[10925] "Asparaginase_Cyclophosphamide_Cytarabine_Daunorubicin_Dexamethasone_Mercaptopurine_Methotrexate_Thioguanine_Vincristine"                                              
[10926] "Dexamethasone_Rituximab"                                                                                                                                              
[10927] "Interferon-Alfa_Interleukin-2-Liposome_Polyvalent-Melanoma-Vaccine"                                                                                                   
[10928] "Asparaginase_Dexamethasone_Etoposide_Mitoxantrone"                                                                                                                    
[10929] "Asparaginase_Mercaptopurine_Methotrexate_Vincristine"                                                                                                                 
[10930] "Cytarabine_Mercaptopurine_Methotrexate_Prednisone"                                                                                                                    
[10931] "Methotrexate_Methylprednisolone"                                                                                                                                      
[10932] "Carboplatin_Melphalan"                                                                                                                                                
[10933] "Cisplatin_Flavopiridol"                                                                                                                                               
[10934] "Amifostine_Etoposide"                                                                                                                                                 
[10935] "Gemcitabine_R115777"                                                                                                                                                  
[10936] "Amifostine_Carboplatin_Etoposide_Ifosfamide"                                                                                                                          
[10937] "Cyclophosphamide_Cytarabine_Methotrexate"                                                                                                                             
[10938] "Dextromethorphan_Morphine"                                                                                                                                            
[10939] "Cytarabine_Hydrocortisone_Leucovorin-Calcium_Methotrexate"                                                                                                            
[10940] "Irinotecan_Mitomycin"                                                                                                                                                 
[10941] "Capecitabine_Docetaxel"                                                                                                                                               
[10942] "Cisplatin_Irinotecan_Paclitaxel"                                                                                                                                      
[10943] "Cyclophosphamide_Thalidomide"                                                                                                                                         
[10944] "Dexamethasone_Floxuridine_Irinotecan"                                                                                                                                 
[10945] "Flutamide_Triptorelin"                                                                                                                                                
[10946] "Carboplatin_Temozolomide"                                                                                                                                             
[10947] "Cisplatin_OXi-104"                                                                                                                                                    
[10948] "Docetaxel_Gemcitabine"                                                                                                                                                
[10949] "Interleukin-2_Ras-Peptide-Cancer-Vaccine"                                                                                                                             
[10950] "Penicillamine_Pyridoxine"                                                                                                                                             
[10951] "Interferon-Alfa_Toremifene"                                                                                                                                           
[10952] "Asparaginase_Dexamethasone_Prednisone_Vincristine"                                                                                                                    
[10953] "Carboplatin_Paclitaxel_PSC-833"                                                                                                                                       
[10954] "Amifostine_Carmustine_Cyclophosphamide_Cytarabine_Etoposide"                                                                                                          
[10955] "Amifostine_Carboplatin_Cyclophosphamide_Thiotepa"                                                                                                                     
[10956] "Fluorouracil_Oxaliplatin"                                                                                                                                             
[10957] "gp100-Antigen_MAGE-3-1_MART-1-Antigen_Tyrosinase-Peptide"                                                                                                             
[10958] "Flu-Matrix_gp100-Antigen_MAGE-3-1_MART-1-Antigen_Tyrosinase-Peptide"                                                                                                  
[10959] "Docetaxel_Doxorubicin_Tamoxifen"                                                                                                                                      
[10960] "Cyclophosphamide_Docetaxel_Doxorubicin_Tamoxifen"                                                                                                                     
[10961] "Methotrexate_Prednisolone"                                                                                                                                            
[10962] "Dexamethasone_Methotrexate"                                                                                                                                           
[10963] "Asparaginase_Daunorubicin_Dexamethasone_Methotrexate_Vincristine"                                                                                                     
[10964] "Asparaginase_Cyclophosphamide_Daunorubicin_Methotrexate_Prednisolone_Vincristine"                                                                                     
[10965] "Asparaginase_Cytarabine_Mercaptopurine_Methotrexate"                                                                                                                  
[10966] "Asparaginase_Cyclophosphamide_Cytarabine_Mercaptopurine"                                                                                                              
[10967] "Cytarabine_Methotrexate_Thioguanine"                                                                                                                                  
[10968] "Asparaginase_Leucovorin-Calcium_Mercaptopurine_Methotrexate"                                                                                                          
[10969] "Asparaginase_Cyclophosphamide_Daunorubicin_Dexamethasone_leucovorin-calcium_Methotrexate_Thioguanine_Vindesine"                                                       
[10970] "Asparaginase_Cytarabine_Dexamethasone_leucovorin-calcium_Mercaptopurine_Methotrexate_Vincristine"                                                                     
[10971] "Asparaginase_Cytarabine_Dexamethasone_Etoposide_Mitoxantrone"                                                                                                         
[10972] "Asparaginase_Cyclophosphamide_Cytarabine_Daunorubicin_Dexamethasone_Mercaptopurine_Methotrexate_Thioguanine_Vincristine_Vindesine"                                    
[10973] "Asparaginase_Daunorubicin_Methotrexate_Prednisolone_Vincristine"                                                                                                      
[10974] "Alendronate-Sodium_Ketoconazole"                                                                                                                                      
[10975] "Amifostine_Bleomycin_Cisplatin_Etoposide"                                                                                                                             
[10976] "Piperacillin_Tazobactam_Vancomycin"                                                                                                                                   
[10977] "Fowlpox-Virus-Vaccine_Interleukin-2"                                                                                                                                  
[10978] "Isotretinoin_Temozolomide"                                                                                                                                            
[10979] "Cyclosporine_Interferon-Alfa_Sargramostim"                                                                                                                            
[10980] "Carboplatin_Paclitaxel_SCH-58500"                                                                                                                                     
[10981] "Amifostine_Cytarabine_Topotecan"                                                                                                                                      
[10982] "Aminopterin_Leucovorin-Calcium"                                                                                                                                       
[10983] "Carboplatin_Thiotepa_Vincristine"                                                                                                                                     
[10984] "gp100-Antigen_Incomplete-Freunds-Adjuvant_MART-1-Antigen"                                                                                                             
[10985] "gp100-Antigen_Incomplete-Freunds-Adjuvant_Interleukin-2_MART-1-Antigen"                                                                                               
[10986] "Gentamicin_Piperacillin_Vancomycin"                                                                                                                                   
[10987] "Asparaginase_Prednisone_Vincristine"                                                                                                                                  
[10988] "Cisplatin_Epirubicin"                                                                                                                                                 
[10989] "Amikacin_Ceftazidime"                                                                                                                                                 
[10990] "Amikacin_Ceftriaxone"                                                                                                                                                 
[10991] "Azacytidine_Carboplatin"                                                                                                                                              
[10992] "Cyclophosphamide_Detox-B-Adjuvant_Interleukin-2"                                                                                                                      
[10993] "Deoxyspergualin_Monoclonal-Antibody-L6"                                                                                                                               
[10994] "Fluorouracil_Interferon-Alfa_Leucovorin-Calcium_Mitoxantrone_Vinblastine"                                                                                             
[10995] "Doxorubicin_Pegaspargase_Prednisone_Vincristine"                                                                                                                      
[10996] "Doxorubicin_Ifosfamide_Methotrexate_Muramyl-TriPeptide-Phosphatidylethanolamine"                                                                                      
[10997] "Detox-B-Adjuvant_Keyhole-Limpet-Hemocyanin_Sialyl-Tn-Antigen"                                                                                                         
[10998] "Keyhole-Limpet-Hemocyanin_QS21_Sialyl-Tn-Antigen"                                                                                                                     
[10999] "Cyclophosphamide_Doxorubicin_Monoclonal-Antibody-HER2"                                                                                                                
[11000] "MAGE-3_PADRE-965-10"                                                                                                                                                  
[11001] "Fluorouracil_Levamisole_Monoclonal-Antibody-17-1A"                                                                                                                    
[11002] "Monoclonal-Antibody-C225_Paclitaxel"                                                                                                                                  
[11003] "Doxorubicin_Monoclonal-Antibody-C225"                                                                                                                                 
[11004] "GM2-KLH-Vaccine_QS21"                                                                                                                                                 
[11005] "Interferon-Alfa_Bexarotene"                                                                                                                                           
[11006] "Cyclophosphamide_Epirubicin_Monoclonal-Antibody-HER2"                                                                                                                 
[11007] "Monoclonal-Antibody-HER2_Paclitaxel"                                                                                                                                  
[11008] "Fluorouracil_Leucovorin-Calcium_Monoclonal-Antibody-17-1A"                                                                                                            
[11009] "UFT_Leucovorin"                                                                                                                                                       
[11010] "Epirubicin_Fluorouracil"                                                                                                                                              
[11011] "gp100-Antigen_Incomplete-Freunds-Adjuvant_MART-1-Antigen_Tyrosinase-Peptide"                                                                                          
[11012] "gp100-Antigen_Incomplete-Freunds-Adjuvant_Interleukin-2_MART-1Antigen_Tyrosinase-Peptide"                                                                             
[11013] "gp100-Antigen_Incomplete-Freunds-Adjuvant_Interleukin-12_MART-1Antigen_Tyrosinase-Peptide"                                                                            
[11014] "Incomplete-Freunds-Adjuvant_Interleukin-12_Tyrosinase-Related-Protein-1"                                                                                              
[11015] "Cisplatin_Monoclonal-Antibody-C225"                                                                                                                                   
[11016] "Incomplete-Freunds-Adjuvant_Peptide-946-Tetanus-Peptide-Conjugate-Melanoma-Vaccine"                                                                                   
[11017] "AG3340_Mitoxantrone_Prednisone"                                                                                                                                       
[11018] "QS21_Tn_c_KLH-Conjugate-Vaccine"                                                                                                                                      
[11019] "Cyclophosphamide_Etoposide_iodine-I-131-Monoclonal-Antibody-Anti-B1"                                                                                                  
[11020] "gp100-Antigen_QS21_Tyrosinase-Peptide"                                                                                                                                
[11021] "Carboplatin_Docetaxel_Ifosfamide"                                                                                                                                     
[11022] "Incomplete-Freunds-Adjuvant_Interleukin-2_Von-Hippel-Lindau-Peptide-Vaccine"                                                                                          
[11023] "ALVAC-hB7-1_Canarypox-hIL-12-Melanoma-Vaccine"                                                                                                                        
[11024] "Allovectin-7_Dacarbazine"                                                                                                                                             
[11025] "Carboplatin_Monoclonal-Antibody-HER2_Paclitaxel"                                                                                                                      
[11026] "Irinotecan_LY231514"                                                                                                                                                  
[11027] "Interleukin-2_Monoclonal-Antibody-Anti-Tac"                                                                                                                           
[11028] "IDEC-In2B8_Rituximab"                                                                                                                                                 
[11029] "gp100-Antigen_MAGE-3_MART-1-Antigen_Tyrosinase-Peptide"                                                                                                               
[11030] "Flu-Matrix_gp100-Antigen_MAGE-3_MART-1-Antigen_Tyrosinase-Peptide"                                                                                                    
[11031] "Gemcitabine_Monoclonal-Antibody-HER2"                                                                                                                                 
[11032] "KSA-Glycoprotein_QS21"                                                                                                                                                
[11033] "KSA-KLH-Conjugate-Vaccine_QS21"                                                                                                                                       
[11034] "QS21_TF_c_KLH-Conjugate-Vaccine"                                                                                                                                      
[11035] "Capecitabine_Irinotecan"                                                                                                                                              
[11036] "Iodine-I-125_Polifeprosan-20-With-Carmustine-Implant"                                                                                                                 
[11037] "Amifostine_Cisplatin_Fluorouracil_Paclitaxel"                                                                                                                         
[11038] "Cisplatin_Flavopiridol_Paclitaxel"                                                                                                                                    
[11039] "Capecitabine_Vinorelbine"                                                                                                                                             
[11040] "Fludarabine_Melphalan"                                                                                                                                                
[11041] "Cyclophosphamide_Epirubicin_Fluorouracil_Methotrexate"                                                                                                                
[11042] "Docetaxel_Irinotecan"                                                                                                                                                 
[11043] "Fowlpox-Virus-Vaccine_Interleukin-2_Vaccinia-Tyrosinase-Vaccine"                                                                                                      
[11044] "Interleukin-2_Vaccinia-Tyrosinase-Vaccine"                                                                                                                            
[11045] "Amifostine_Cyclophosphamide_Doxorubicin_Paclitaxel"                                                                                                                   
[11046] "Docetaxel_GEM-231"                                                                                                                                                    
[11047] "GEM-231_Paclitaxel"                                                                                                                                                   
[11048] "Fluorouracil_Leucovorin-Calcium_SCH-66336"                                                                                                                            
[11049] "Cytarabine_Daunorubicin_Tretinoin"                                                                                                                                    
[11050] "Daunorubicin_Tretinoin"                                                                                                                                               
[11051] "Fluorouracil-Uracil_Gemcitabine_Leucovorin-Calcium"                                                                                                                   
[11052] "CRL-1005_gp100-Antigen_Incomplete-Freunds-Adjuvant_Tyrosinase-Peptide"                                                                                                
[11053] "gp100-Antigen_Incomplete-Freunds-Adjuvant_Sargramostim_Tyrosinase-Peptide"                                                                                            
[11054] "Methotrexate_Prednisone"                                                                                                                                              
[11055] "Lomustine_Procarbazine"                                                                                                                                               
[11056] "Leflunomide_Mitoxantrone"                                                                                                                                             
[11057] "Fluorouracil_Leucovorin-Calcium_SU5416"                                                                                                                               
[11058] "Cyclosporine_Irinotecan"                                                                                                                                              
[11059] "Detoxpc_Lung-Tumor-Associated-Antigen"                                                                                                                                
[11060] "Anti-Thymocyte-Globulin_Methylprednisolone"                                                                                                                           
[11061] "Anti-Thymocyte-Globulin_Cyclophosphamide_Methylprednisolone"                                                                                                          
[11062] "Anti-Thymocyte-Globulin_Melphalan_Methylprednisolone"                                                                                                                 
[11063] "Irinotecan_Vincristine"                                                                                                                                               
[11064] "Rituximab_Vinorelbine"                                                                                                                                                
[11065] "Cisplatin_Dexrazoxane_Doxorubicin"                                                                                                                                    
[11066] "Dexrazoxane_Doxorubicin_Ifosfamide"                                                                                                                                   
[11067] "Doxorubicin_P-30-Protein"                                                                                                                                             
[11068] "Capecitabine_Oxaliplatin"                                                                                                                                             
[11069] "Fluorouracil_Vincristine"                                                                                                                                             
[11070] "Carboplatin_Paclitaxel_Thalidomide"                                                                                                                                   
[11071] "Bleomycin_Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Procarbazine_Vincristine"                                                                                 
[11072] "Autologous-Tumor-Cell-Vaccine_Sargramostim"                                                                                                                           
[11073] "Cisplatin_Fluorouracil_Gemcitabine"                                                                                                                                   
[11074] "Tamoxifen_Trastuzumab"                                                                                                                                                
[11075] "Fludarabine_UCN-01"                                                                                                                                                   
[11076] "Irinotecan_Trastuzumab"                                                                                                                                               
[11077] "MAGE-3_SB-AS-2"                                                                                                                                                       
[11078] "Bryostatin-1_Interleukin-2"                                                                                                                                           
[11079] "Cyclophosphamide_Doxorubicin_Etoposide_Fludarabine_Prednisone_Vincristine"                                                                                            
[11080] "Anti-Thymocyte-Globulin_Thiotepa"                                                                                                                                     
[11081] "Leflunomide_Mitoxantrone_Prednisone"                                                                                                                                  
[11082] "L-778-123_Paclitaxel"                                                                                                                                                 
[11083] "Fluorouracil_UCN-01"                                                                                                                                                  
[11084] "gp100-Antigen_Montanide-ISA-51_Tyrosinase-Peptide"                                                                                                                    
[11085] "gp100-Antigen_MART-1-Antigen_Montanide-ISA-51"                                                                                                                        
[11086] "gp100-Antigen_Interleukin-2_MART-1-Antigen_Montanide-ISA-51"                                                                                                          
[11087] "MART-1-Antigen_Montanide-ISA-51"                                                                                                                                      
[11088] "Montanide-ISA-51_Peptide-946-Melanoma-Vaccine"                                                                                                                        
[11089] "Montanide-ISA-51_Peptide-946-Tetanus-Peptide-Conjugate-Melanoma-Vaccine"                                                                                              
[11090] "Docetaxel_Mitoxantrone"                                                                                                                                               
[11091] "Montanide-ISA-51_Peptide-946-Melanoma-Vaccine_Tetanus-Peptide-Melanoma-Vaccine"                                                                                       
[11092] "gp100-Antigen_HPV-16-E7_12-20_Peptide-Vaccine_Montanide-ISA-51"                                                                                                       
[11093] "Dexamethasone_Floxuridine_Leucovorin-Calcium_SCH-58500"                                                                                                               
[11094] "gp100-Antigen_Interleukin-12_Montanide-ISA-51_Tyrosinase-Peptide"                                                                                                     
[11095] "gp100-Antigen_Montanide-ISA-51_Sargramostim_Tetanus-Peptide-Melanoma-Vaccine_Tyrosinase-Peptide"                                                                      
[11096] "Montanide-ISA-51_von-Hippel-Lindau-Peptide-Vaccine"                                                                                                                   
[11097] "Interleukin-2_Montanide-ISA-51_Von-Hippel-Lindau-Peptide-Vaccine"                                                                                                     
[11098] "Montanide-ISA-51_Sargramostim_von-Hippel-Lindau-Peptide-Vaccine"                                                                                                      
[11099] "gp100-Antigen_Interleukin-2_Montanide-ISA-51"                                                                                                                         
[11100] "Cyclosporine_Irinotecan_Phenobarbital"                                                                                                                                
[11101] "gp100-Antigen_Montanide-ISA-51"                                                                                                                                       
[11102] "Montanide-ISA-51_Tyrosinase-Peptide"                                                                                                                                  
[11103] "Interleukin-2_Montanide-ISA-51_Tyrosinase-Peptide"                                                                                                                    
[11104] "Interleukin-12_Montanide-ISA-51_Tyrosinase-Peptide"                                                                                                                   
[11105] "Montanide-ISA-51_Sargramostim_Tyrosinase-Peptide"                                                                                                                     
[11106] "gp100-Antigen_Interleukin-12_Montanide-ISA-51"                                                                                                                        
[11107] "gp100-Antigen_Montanide-ISA-51_Sargramostim"                                                                                                                          
[11108] "Montanide-ISA-51_Tyrosinase-Related-Protein-1"                                                                                                                        
[11109] "Interleukin-2_Montanide-ISA-51_Tyrosinase-Related-Protein-1"                                                                                                          
[11110] "Interleukin-12_Montanide-ISA-51_Tyrosinase-Related-Protein-1"                                                                                                         
[11111] "Montanide-ISA-51_Sargramostim_Tyrosinase-Related-Protein-1"                                                                                                           
[11112] "gp100-Antigen_MART-1-Antigen_Montanide-ISA-51_Tyrosinase-Peptide"                                                                                                     
[11113] "gp100-Antigen_Interleukin-2_MART-1-Antigen_Montanide-ISA-51_Tyrosinase-Peptide"                                                                                       
[11114] "gp100-Antigen_MART-1-Antigen_Montanide-ISA-51_Sargramostim_Tyrosinase-Peptide"                                                                                        
[11115] "Flt3-Ligand_gp100-Antigen_MART-1-Antigen_Montanide-ISA-51_Tyrosinase-Peptide"                                                                                         
[11116] "CRL-1005_gp100-Antigen_Montanide-ISA-51_Tyrosinase-Peptide"                                                                                                           
[11117] "gp100-Antigen_Montanide-ISA-51_Sargramostim_Tyrosinase-Peptide"                                                                                                       
[11118] "Interleukin-12_MART-1-Antigen_Montanide-ISA-51"                                                                                                                       
[11119] "HER-2-neu-Peptide-Vaccine_Montanide-ISA-51"                                                                                                                           
[11120] "Bcr-Abl-Peptide-Vaccine_QS21"                                                                                                                                         
[11121] "E7_86-93_LipoPeptide_HPV-16-E7_12-20_Peptide-Vaccine_Montanide-ISA-51"                                                                                                
[11122] "Mutant-P53-Peptide-Pulsed-Dendritic-Cell-Vaccine_Sargramostim"                                                                                                        
[11123] "Montanide-ISA-51_p53-Peptide-Vaccine_Sargramostim"                                                                                                                    
[11124] "gp100-Antigen_MART-1-Antigen_Tyrosinase-Peptide"                                                                                                                      
[11125] "Carboplatin_Vinorelbine"                                                                                                                                              
[11126] "Fluorouracil_Gemcitabine_Paclitaxel"                                                                                                                                  
[11127] "Adenovirus_CD40-ligand"                                                                                                                                               
[11128] "gp100-Antigen_Tetanus-Peptide-Melanoma-Vaccine_Tyrosinase-Peptide"                                                                                                    
[11129] "Carboplatin_Docetaxel_Gemcitabine"                                                                                                                                    
[11130] "Estramustine_Paclitaxel_Vinorelbine"                                                                                                                                  
[11131] "Oxaliplatin_Paclitaxel"                                                                                                                                               
[11132] "Bicalutamide_Goserelin_Mitoxantrone_Prednisone"                                                                                                                       
[11133] "Autologous-Tumor-Cell-Vaccine_Keyhole-Limpet-Hemocyanin_Sargramostim"                                                                                                 
[11134] "Interleukin-2_Vaccine-Sensitized-Draining-Lymph-Node-Cells"                                                                                                           
[11135] "HER-2-Neu-Peptide-Vaccine_Sargramostim"                                                                                                                               
[11136] "Rituximab_Y-90-ibritumomab-tiuxetan"                                                                                                                                  
[11137] "LY335979_Vinorelbine"                                                                                                                                                 
[11138] "gp100-Antigen_Interleukin-2_Montanide-ISA-51_Tumor-Infiltrating-Lymphocytes"                                                                                          
[11139] "BCG_Polyvalent-Melanoma-Vaccine"                                                                                                                                      
[11140] "Cisplatin_Cytarabine_Etoposide_Ifosfamide_Yttrium-Y-90-Humanized-Epratuzumab"                                                                                         
[11141] "Filgrastim_Interleukin-11"                                                                                                                                            
[11142] "Keyhole-limpet-hemocyanin_MUC-1-Antigen_QS21"                                                                                                                         
[11143] "BCG_Interferon-alfa"                                                                                                                                                  
[11144] "Bryostatin-1_Gemcitabine"                                                                                                                                             
[11145] "Carboplatin_Ifosfamide_Thiotepa"                                                                                                                                      
[11146] "Doxorubicin-Hcl-Liposome_Methotrexate_Prednisone_Vincristine"                                                                                                         
[11147] "Cyclophosphamide_Cytarabine_Fludarabine"                                                                                                                              
[11148] "Asparaginase_Dexamethasone"                                                                                                                                           
[11149] "Dexamethasone_Methotrexate_Vincristine"                                                                                                                               
[11150] "Daunorubicin_Vincristine"                                                                                                                                             
[11151] "Prinomastat_Temozolomide"                                                                                                                                             
[11152] "Cisplatin_Gemcitabine_Prinomastat"                                                                                                                                    
[11153] "Gemcitabine_Oxaliplatin"                                                                                                                                              
[11154] "Cisplatin_Rebeccamycin-Analogue"                                                                                                                                      
[11155] "Alum-Adjuvant_Monoclonal-Antibody-4B5-Anti-Idiotype-Vaccine"                                                                                                          
[11156] "Monoclonal-antibody-4B5-anti-idiotype-Vaccine_Sargramostim"                                                                                                           
[11157] "Anti-Thymocyte-Globulin_Cyclosporine"                                                                                                                                 
[11158] "Fluorouracil_Leucovorin-Calcium_Triacetyluridine"                                                                                                                     
[11159] "Cytarabine_Leucovorin-Calcium"                                                                                                                                        
[11160] "Cytarabine_Daunorubicin_PSC-833"                                                                                                                                      
[11161] "Tamoxifen_Tretinoin"                                                                                                                                                  
[11162] "Asparaginase_cyclophosphamide_cytarabine_daunorubicin_dexamethasone_methotrexate_thioguanine_vincristine"                                                             
[11163] "Asparaginase_cyclophosphamide_cytarabine_daunorubicin_methotrexate_prednisone_vincristine"                                                                            
[11164] "Cyclophosphamide_Cytarabine_Mercaptopurine_Methotrexate_Prednisone"                                                                                                   
[11165] "Asparaginase_cytarabine_daunorubicin_methotrexate_prednisone_vincristine"                                                                                             
[11166] "Docetaxel_Oxaliplatin"                                                                                                                                                
[11167] "Amifostine_Cisplatin_Docetaxel"                                                                                                                                       
[11168] "Keyhole-limpet-hemocyanin_polysialic-Acid"                                                                                                                            
[11169] "Keyhole-limpet-hemocyanin_polysialic-Acid_QS21"                                                                                                                       
[11170] "Exemestane_Raloxifene"                                                                                                                                                
[11171] "Cytarabine_UCN-01"                                                                                                                                                    
[11172] "Interleukin-12_Rituximab"                                                                                                                                             
[11173] "Fluorouracil_Gemcitabine_Oxaliplatin"                                                                                                                                 
[11174] "Dactinomycin_Melphalan"                                                                                                                                               
[11175] "Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Rituximab_Vincristine"                                                                                              
[11176] "Irinotecan_Oblimersen"                                                                                                                                                
[11177] "Doxorubicin-HCl-Liposome_Trastuzumab"                                                                                                                                 
[11178] "Amifostine_Cisplatin_Irinotecan"                                                                                                                                      
[11179] "Docetaxel_Thalidomide"                                                                                                                                                
[11180] "Cisplatin_Raltitrexed"                                                                                                                                                
[11181] "Carboplatin_Epirubicin_Paclitaxel"                                                                                                                                    
[11182] "Cytarabine_Fludarabine_Oblimersen"                                                                                                                                    
[11183] "Docetaxel_MS-209"                                                                                                                                                     
[11184] "MUC-2-KLH-Vaccine_QS21"                                                                                                                                               
[11185] "O6-Benzylguanine_Polifeprosan-20-With-Carmustine-Implant"                                                                                                             
[11186] "Ifosfamide_Paclitaxel_Teniposide"                                                                                                                                     
[11187] "Docetaxel_Doxorubicin-Hcl-Liposome_Trastuzumab"                                                                                                                       
[11188] "Vinorelbine_XR9576"                                                                                                                                                   
[11189] "Montanide-ISA-51_PR1-Leukemia-Peptide-Vaccine_Sargramostim"                                                                                                           
[11190] "Biomed-101_Interleukin-2"                                                                                                                                             
[11191] "Anti-Thymocyte-Globulin_Methylprednisolone_Tacrolimus"                                                                                                                
[11192] "CI-994_Gemcitabine"                                                                                                                                                   
[11193] "Eniluracil_Fluorouracil_Oxaliplatin"                                                                                                                                  
[11194] "Cisplatin_Tirapazamine_Vinorelbine"                                                                                                                                   
[11195] "Cetuximab_Irinotecan"                                                                                                                                                 
[11196] "Cisplatin_Cyclophosphamide_Etoposide_Mafosfamide_Vincristine"                                                                                                         
[11197] "Fluorouracil_irinotecan_leucovorin-calcium_oxaliplatin"                                                                                                               
[11198] "Carboplatin_Paclitaxel_Tirapazamine"                                                                                                                                  
[11199] "Docetaxel_Methotrexate"                                                                                                                                               
[11200] "Oblimersen_Paclitaxel"                                                                                                                                                
[11201] "Cetuximab_Gemcitabine"                                                                                                                                                
[11202] "Carboplatin_Etoposide_Topotecan"                                                                                                                                      
[11203] "Carboplatin_Etoposide_Ifosfamide_Rituximab"                                                                                                                           
[11204] "Asparaginase_cyclophosphamide_cytarabine_daunorubicin_thioguanine"                                                                                                    
[11205] "Asparaginase_cyclophosphamide_cytarabine_daunorubicin_dexamethasone_leucovorin-calcium_mercaptopurine_methotrexate_thioguanine_vincristine"                           
[11206] "Interleukin-2_Interleukin-12"                                                                                                                                         
[11207] "Carboplatin_Docetaxel_Estramustine"                                                                                                                                   
[11208] "Capecitabine_Paclitaxel"                                                                                                                                              
[11209] "Cisplatin_Cytarabine_Dexamethasone_Rituximab"                                                                                                                         
[11210] "Amifostine_Azacitidine"                                                                                                                                               
[11211] "Paclitaxel_SU5416"                                                                                                                                                    
[11212] "Carboplatin_Fludarabine"                                                                                                                                              
[11213] "AFP-Gene-Hepatocellular-Carcinoma-Vaccine_Montanide-ISA-51"                                                                                                           
[11214] "RAS-Peptide-Cancer-Vaccine_Sargramostim"                                                                                                                              
[11215] "Azacitidine_Phenylbutyrate"                                                                                                                                           
[11216] "gp209-2M-Antigen_Heat-Shock-Protein-70_OVA-Bip-Peptide_Tyrosinase-Peptide"                                                                                            
[11217] "Carboplatin_Paclitaxel_ZD-1839"                                                                                                                                       
[11218] "Filgrastim_Flt3-Ligand_Milodistim_Sargramostim"                                                                                                                       
[11219] "BiSpecific-Antibody-MDX447_Lymphokine-Activated-Killer-Cells"                                                                                                         
[11220] "Doxorubicin_SU5416"                                                                                                                                                   
[11221] "Carmustine_RSR13"                                                                                                                                                     
[11222] "Estramustine_Mitoxantrone_Vinorelbine"                                                                                                                                
[11223] "Interferon-Alfa_Isotretinoin_Paclitaxel"                                                                                                                              
[11224] "Cisplatin_Fluorouracil_Irinotecan"                                                                                                                                    
[11225] "Etoposide-Phosphate_Melphalan_Topotecan"                                                                                                                              
[11226] "Cytarabine_Daunorubicin_Etoposide_Topotecan"                                                                                                                          
[11227] "Cisplatin_Mitomycin_Tretinoin_Vinorelbine"                                                                                                                            
[11228] "Cisplatin_Tretinoin_Vinorelbine"                                                                                                                                      
[11229] "Cisplatin_Fenretinide_Paclitaxel"                                                                                                                                     
[11230] "Cisplatin_Cyclophosphamide_Dexamethasone_Etoposide_Thalidomide"                                                                                                       
[11231] "Carboplatin_Paclitaxel_Shark-Cartilage"                                                                                                                               
[11232] "Cisplatin_Shark-Cartilage_Vinorelbine"                                                                                                                                
[11233] "Docetaxel_Trastuzumab"                                                                                                                                                
[11234] "Cytarabine_Daunorubicin_Etoposide_Tretinoin"                                                                                                                          
[11235] "Cytarabine_Filgrastim_Fludarabine"                                                                                                                                    
[11236] "Cytarabine_Fludarabine_Tretinoin"                                                                                                                                     
[11237] "Carboplatin_Gemcitabine_Paclitaxel_Trastuzumab"                                                                                                                       
[11238] "Temozolomide_Thalidomide"                                                                                                                                             
[11239] "Filgrastim-Fetal-Liver-Tyrosine-Kinase-3-Fusion-Protein_gp100-Antigen_MART-1-Antigen_Montanide-ISA-51_Tyrosinase-Peptide"                                             
[11240] "Bleomycin_Cyclophosphamide_Etoposide_Mitoxantrone_Prednisolone_Vincristine"                                                                                           
[11241] "Eflornithine_Sulindac"                                                                                                                                                
[11242] "Celecoxib_Selenium"                                                                                                                                                   
[11243] "O6-benzylguanine_Temozolomide"                                                                                                                                        
[11244] "Irinotecan_SU5416"                                                                                                                                                    
[11245] "Cyclosporine_Filgrastim_Methylprednisolone_Monoclonal-Antibody-Okt3"                                                                                                  
[11246] "Floxuridine_Leucovorin-Calcium_Oxaliplatin"                                                                                                                           
[11247] "R115777_Trastuzumab"                                                                                                                                                  
[11248] "Interleukin-2_Staphylococcal-Enterotoxin-B"                                                                                                                           
[11249] "Cisplatin_Lurtotecan-Liposome"                                                                                                                                        
[11250] "Cyclophosphamide_Dexamethasone_Mitoxantrone"                                                                                                                          
[11251] "Cisplatin_Gemcitabine_ZD-1839"                                                                                                                                        
[11252] "Cyclophosphamide_Cytarabine_Dexamethasone_Mitoxantrone"                                                                                                               
[11253] "Irinotecan_Temozolomide"                                                                                                                                              
[11254] "Anti-Human-Chorionic-Gonadotropin-Vaccine_Gemcitabine"                                                                                                                
[11255] "Carboplatin_Pyrazoloacridine"                                                                                                                                         
[11256] "Leucovorin-Calcium_Methotrexate"                                                                                                                                      
[11257] "Cisplatin_Irinotecan_SU5416"                                                                                                                                          
[11258] "Interleukin-2_Stem-Cell-Factor"                                                                                                                                       
[11259] "Fluorouracil_Leucovorin-Calcium_Oxaliplatin_Trastuzumab"                                                                                                              
[11260] "Dexamethasone_SU5416"                                                                                                                                                 
[11261] "Gemcitabine_Pemetrexed-Disodium"                                                                                                                                      
[11262] "Arsenic-Trioxide_Ascorbic-Acid"                                                                                                                                       
[11263] "Doxorubicin_Methotrexate_Pegaspargase_Vincristine"                                                                                                                    
[11264] "Cyclophosphamide_Methotrexate_Pegaspargase_Vincristine"                                                                                                               
[11265] "Daunorubicin_dexamethasone_methotrexate_vincristine"                                                                                                                  
[11266] "Gemcitabine_SU5416"                                                                                                                                                   
[11267] "Cytarabine_Dexamethasone_Leucovorin-Calcium_Methotrexate"                                                                                                             
[11268] "Dexamethasone_Etoposide_Ifosfamide"                                                                                                                                   
[11269] "Daunorubicin-Liposomal_SU5416"                                                                                                                                        
[11270] "Interferon-Alfa_Thalidomide"                                                                                                                                          
[11271] "R115777_Topotecan"                                                                                                                                                    
[11272] "Doxorubicin-Hcl-Liposome_Gemcitabine_Vinorelbine"                                                                                                                     
[11273] "Lomustine_Temozolomide"                                                                                                                                               
[11274] "Fluorouracil_IM-862"                                                                                                                                                  
[11275] "IM-862_Irinotecan"                                                                                                                                                    
[11276] "Etoposide_Nitrocamptothecin"                                                                                                                                          
[11277] "Cytarabine_Etoposide_Mitoxantrone_Monoclonal-Antibody-Hug1-M195"                                                                                                      
[11278] "MUC-1-KLH-Vaccine_QS21"                                                                                                                                               
[11279] "Filgrastim_Mycophenolate-Mofetil_Tacrolimus"                                                                                                                          
[11280] "BMS-214662_Paclitaxel"                                                                                                                                                
[11281] "Cytarabine_Gemtuzumab-Ozogamicin"                                                                                                                                     
[11282] "Cytarabine_Daunorubicin-Liposomal"                                                                                                                                    
[11283] "Cyclophosphamide_Cytarabine_Topotecan"                                                                                                                                
[11284] "Doxorubicin-Hcl-Liposome_Gemcitabine"                                                                                                                                 
[11285] "gp209-2M-Antigen_Interleukin-2_Montanide-ISA-51"                                                                                                                      
[11286] "Cisplatin_Gemcitabine_Paclitaxel"                                                                                                                                     
[11287] "BMS-188797_Carboplatin"                                                                                                                                               
[11288] "Autologous-Dendritic-Cells_Candida-Albicans-Skin-Test-Reagent_CD40-Ligand_gp100-Antigen_Interferon-Gamma_Interleukin-4_MART-1-Antigen_Sargramostim_Tyrosinase-Peptide"
[11289] "Capecitabine_Paclitaxel_Trastuzumab"                                                                                                                                  
[11290] "rV-B7-1-Vaccine_Vaccinia-Prostate-Specific-Antigen-Vaccine"                                                                                                           
[11291] "Dexamethasone_Idarubicin"                                                                                                                                             
[11292] "Carboplatin_Temozolomide_Vincristine"                                                                                                                                 
[11293] "Arginine-Butyrate_Ganciclovir"                                                                                                                                        
[11294] "Chlorambucil_Dexamethasone_Mitoxantrone"                                                                                                                              
[11295] "Irinotecan_Octreotide"                                                                                                                                                
[11296] "DX-8951f_Gemcitabine"                                                                                                                                                 
[11297] "Docetaxel_Cyclophosphamide"                                                                                                                                           
[11298] "Interleukin-2_Trastuzumab"                                                                                                                                            
[11299] "MAGE-12-Peptide-Vaccine_Montanide-ISA-51"                                                                                                                             
[11300] "Interleukin-2_MAGE-12-Peptide-Vaccine_Montanide-ISA-51"                                                                                                               
[11301] "Dexamethasone_Phenylbutyrate_Sargramostim"                                                                                                                            
[11302] "Interferon-Alfa_Lu-177-Monoclonal-Antibody-CC49_Paclitaxel"                                                                                                           
[11303] "Interferon-Alfa_Lu-177-Monoclonal-Antibody-CC49_Topotecan"                                                                                                            
[11304] "Interferon-Alfa_Paclitaxel_Yttrium-Y-90-Monoclonal-Antibody-CC49"                                                                                                     
[11305] "BMS-275291_Carboplatin_Paclitaxel"                                                                                                                                    
[11306] "Arsenic-Trioxide_Tretinoin"                                                                                                                                           
[11307] "Cisplatin_Cyclophosphamide_Etoposide_Methotrexate_Vincristine"                                                                                                        
[11308] "Carboplatin_Doxorubicin-HCl-Liposome"                                                                                                                                 
[11309] "Ganciclovir_Interleukin-2_Zidovudine"                                                                                                                                 
[11310] "Denileukin-Diftitox_Dexamethasone"                                                                                                                                    
[11311] "QS21_RAS-Peptide-Cancer-Vaccine"                                                                                                                                      
[11312] "Interferon-Alfa_SU5416"                                                                                                                                               
[11313] "Celecoxib_Trastuzumab"                                                                                                                                                
[11314] "Carboplatin_SU5416"                                                                                                                                                   
[11315] "Donepezil_Vitamin-E"                                                                                                                                                  
[11316] "Oxaliplatin_Topotecan"                                                                                                                                                
[11317] "Gemcitabine_SCH-66336"                                                                                                                                                
[11318] "gp100-Antigen_Interferon-Alfa_MART-1-Antigen_Montanide-ISA-51_Sargramostim_Tyrosinase-Peptide"                                                                        
[11319] "gp100-Antigen_Interferon-Alfa_MART-1-Antigen_Montanide-ISA-51_Tyrosinase-Peptide"                                                                                     
[11320] "Hydrocortisone_Ketoconazole"                                                                                                                                          
[11321] "Etoposide_Ifosfamide_Topotecan"                                                                                                                                       
[11322] "Fluorouracil_Irinotecan"                                                                                                                                              
[11323] "Docetaxel_Oblimersen"                                                                                                                                                 
[11324] "Cisplatin_Etoposide_Tirapazamine"                                                                                                                                     
[11325] "Paclitaxel_Prinomastat"                                                                                                                                               
[11326] "Carboplatin_Fluorouracil_Paclitaxel"                                                                                                                                  
[11327] "Gemcitabine_ISIS-2503"                                                                                                                                                
[11328] "Doxorubicin_Hydrocortisone_Methotrexate"                                                                                                                              
[11329] "Cytarabine_Dexamethasone_Etoposide_Ifosfamide_Methotrexate_Vinblastine"                                                                                               
[11330] "Cyclophosphamide_Dexamethasone_Doxorubicin_Methotrexate_Vinblastine"                                                                                                  
[11331] "Autologous-Lymphocytes_Interleukin-2"                                                                                                                                 
[11332] "Capecitabine_Irinotecan_Oxaliplatin"                                                                                                                                  
[11333] "Monoclonal-antibody-11D10-anti-idiotype-Vaccine_Monoclonal-antibody-3H1-anti-idiotype-Vaccine"                                                                        
[11334] "Bevacizumab_Thalidomide"                                                                                                                                              
[11335] "Ascorbic-Acid_Selenium"                                                                                                                                               
[11336] "Ascorbic-Acid_Selenium_Vitamin-E"                                                                                                                                     
[11337] "Flavopiridol_irinotecan"                                                                                                                                              
[11338] "Indium-In-111-Monoclonal-Antibody-Bre-3_Yttrium-Y-90-Monoclonal-Antibody-Bre-3"                                                                                       
[11339] "Amifostine_Carboplatin_Epirubicin_Paclitaxel"                                                                                                                         
[11340] "Prednisone_Thalidomide"                                                                                                                                               
[11341] "Cyclophosphamide_Doxorubicin_Iodine-I-131-Tositumomab_Prednisone_Vincristine"                                                                                         
[11342] "Bevacizumab_Fluorouracil_Irinotecan_Leucovorin-Calcium"                                                                                                               
[11343] "Fluorouracil_Leucovorin-Calcium_PS-341"                                                                                                                               
[11344] "Carboplatin_Paclitaxel_Suramin"                                                                                                                                       
[11345] "Capecitabine_Cyclophosphamide_Epirubicin"                                                                                                                             
[11346] "Doxorubicin_Octreotide"                                                                                                                                               
[11347] "Detox-B-Adjuvant_Verteporfin"                                                                                                                                         
[11348] "MUC-1-Antigen_SB-AS-2"                                                                                                                                                
[11349] "Cyclosporine_Yttrium-Y-90-Monoclonal-Antibody-M170"                                                                                                                   
[11350] "Cyclosporine_Paclitaxel_Yttrium-Y-90-Monoclonal-Antibody-M170"                                                                                                        
[11351] "Cyclosporine_Paclitaxel_Yttrium-Y-90-Monoclonal-Antibody-Lym-1"                                                                                                       
[11352] "Cyclosporine_Yttrium-Y-90-Monoclonal-Antibody-Lym-1"                                                                                                                  
[11353] "Flavopiridol_Gemcitabine"                                                                                                                                             
[11354] "Dexamethasone_Floxuridine"                                                                                                                                            
[11355] "Dexamethasone_Doxorubicin_Thalidomide"                                                                                                                                
[11356] "Filgrastim_Melphalan"                                                                                                                                                 
[11357] "Calcitriol_Carboplatin"                                                                                                                                               
[11358] "Cyclophosphamide_Doxorubicin_Etoposide_Rituximab_Vincristine"                                                                                                         
[11359] "Cyclosporine_Methylprednisolone_Mycophenolate-Mofetil"                                                                                                                
[11360] "Anti-Thymocyte-Globulin_Fludarabine_Melphalan"                                                                                                                        
[11361] "Selenium_Vitamin-E"                                                                                                                                                   
[11362] "Imatinib-Mesylate_Interferon-Alfa"                                                                                                                                    
[11363] "Atamestane_Toremifene"                                                                                                                                                
[11364] "Exemestane_Goserelin"                                                                                                                                                 
[11365] "Daunorubicin_Imatinib-Mesylate_Prednisone_Vincristine"                                                                                                                
[11366] "DC-Chol-Liposomes_EGFR-Antisense-DNA"                                                                                                                                 
[11367] "Carboplatin_Irinotecan"                                                                                                                                               
[11368] "Calcitriol_Paclitaxel"                                                                                                                                                
[11369] "Etoposide_Fluorouracil-Uracil_Leucovorin-Calcium"                                                                                                                     
[11370] "Epirubicin_Tamoxifen"                                                                                                                                                 
[11371] "Docetaxel_Tamoxifen"                                                                                                                                                  
[11372] "Calcitriol_Dexamethasone"                                                                                                                                             
[11373] "Fludarabine_Thalidomide"                                                                                                                                              
[11374] "Carboplatin_Etoposide-Phosphate_Ifosfamide"                                                                                                                           
[11375] "Bevacizumab_Fluorouracil_Leucovorin-Calcium"                                                                                                                          
[11376] "Bevacizumab_Irinotecan"                                                                                                                                               
[11377] "Autologous-Dendritic-Cells_Autologous-Tumor-Cell-Vaccine_Sargramostim"                                                                                                
[11378] "Bevacizumab_Capecitabine"                                                                                                                                             
[11379] "Doxorubicin-Hcl-Liposome_Interleukin-12"                                                                                                                              
[11380] "Cisplatin_UCN-01"                                                                                                                                                     
[11381] "Autologous-Tumor-Cell-Vaccine_Interleukin-2"                                                                                                                          
[11382] "Bryostatin-1_Sargramostim"                                                                                                                                            
[11383] "IDEC-In2B8_Rituximab_Yttrium-Y-90-Ibritumomab-Tiuxetan"                                                                                                               
[11384] "Melphalan_Prednisone_Wobe-Mugos-E"                                                                                                                                    
[11385] "Thalidomide_Topotecan"                                                                                                                                                
[11386] "PEG-Interferon-Alfa-2b_Temozolomide"                                                                                                                                  
[11387] "Sulindac_Thalidomide"                                                                                                                                                 
[11388] "Cisplatin_Dexamethasone_Gemcitabine"                                                                                                                                  
[11389] "Carboplatin_Methotrexate_Vinblastine"                                                                                                                                 
[11390] "Docetaxel_Filgrastim_XR9576"                                                                                                                                          
[11391] "Doxorubicin_Filgrastim_XR9576"                                                                                                                                        
[11392] "Trastuzumab_Vinorelbine"                                                                                                                                              
[11393] "Topotecan_ZD9331"                                                                                                                                                     
[11394] "Palivizumab_Ribavirin"                                                                                                                                                
[11395] "Docetaxel_Fluorouracil_Leucovorin-Calcium"                                                                                                                            
[11396] "Detox-B-Adjuvant_RAS-Peptide-Cancer-Vaccine"                                                                                                                          
[11397] "Docetaxel_Filgrastim_Gemcitabine"                                                                                                                                     
[11398] "Bismuth-Bi213-Monoclonal-Antibody-M195_Cytarabine_Filgrastim"                                                                                                         
[11399] "Autologous-Tumor-Cell-Vaccine_BCG"                                                                                                                                    
[11400] "Dacarbazine_Oblimersen"                                                                                                                                               
[11401] "_3-AP_Cisplatin_Paclitaxel"                                                                                                                                           
[11402] "GPI-0100_MUC-2-Globo-H-KLH-Conjugate-Vaccine"                                                                                                                         
[11403] "Interleukin-12_PSA-Prostate-Cancer-Vaccine"                                                                                                                           
[11404] "Leucovorin-calcium_mercaptopurine_methotrexate_prednisolone_vincristine"                                                                                              
[11405] "Cytarabine_Daunorubicin_Dexamethasone_Prednisolone_Thioguanine_Vincristine"                                                                                           
[11406] "Methotrexate_Prednisolone_Prednisone"                                                                                                                                 
[11407] "Asparaginase_cytarabine_daunorubicin_dexamethasone_methotrexate_prednisolone_vincristine"                                                                             
[11408] "Leucovorin-calcium_mercaptopurine_methotrexate_prednisolone"                                                                                                          
[11409] "Asparaginase_cytarabine_daunorubicin_dexamethasone_methotrexate_prednisolone_vindesine"                                                                               
[11410] "Cytarabine_Etoposide_Ifosfamide_Leucovorin-Calcium_Methotrexate_Prednisolone"                                                                                         
[11411] "Cyclophosphamide_Dexrazoxane_Doxorubicin"                                                                                                                             
[11412] "_506U78_Mercaptopurine_Methotrexate"                                                                                                                                  
[11413] "CD40-Ligand_flt3-Ligand"                                                                                                                                              
[11414] "Interferon-Alfa_Lymphokine-Activated-Killer-Cells"                                                                                                                    
[11415] "Doxorubicin-Hcl-Liposome_ZD0473"                                                                                                                                      
[11416] "Docetaxel_Flavopiridol"                                                                                                                                               
[11417] "Bevacizumab_Docetaxel_Estramustine"                                                                                                                                   
[11418] "Cisplatin_Gemcitabine_Trastuzumab"                                                                                                                                    
[11419] "Dexamethasone_Ondansetron"                                                                                                                                            
[11420] "Asparaginase_cytarabine_dexamethasone_vincristine"                                                                                                                    
[11421] "Asparaginase_cytarabine_prednisolone_vincristine"                                                                                                                     
[11422] "Asparaginase_Doxorubicin_Methotrexate_Prednisolone_Vincristine"                                                                                                       
[11423] "Asparaginase_cytarabine_daunorubicin_methotrexate_prednisolone_vincristine"                                                                                           
[11424] "Cyclophosphamide_Cytarabine_Mercaptopurine_Methotrexate_Prednisolone"                                                                                                 
[11425] "Cyclophosphamide_Cytarabine_Dexamethasone_Mercaptopurine_Methotrexate"                                                                                                
[11426] "Dexamethasone_Pegaspargase"                                                                                                                                           
[11427] "Keyhole-limpet-hemocyanin_Sargramostim"                                                                                                                               
[11428] "Carboplatin_ISIS-3521_Paclitaxel"                                                                                                                                     
[11429] "Carboplatin_IM-862_Paclitaxel"                                                                                                                                        
[11430] "Arsenic-Trioxide_Dexamethasone"                                                                                                                                       
[11431] "Epirubicin_Gemcitabine"                                                                                                                                               
[11432] "Bevacizumab_Vinorelbine"                                                                                                                                              
[11433] "Carboplatin_Etoposide_Oblimersen"                                                                                                                                     
[11434] "Carmustine_Cytarabine_Dexamethasone_Etoposide_Melphalan"                                                                                                              
[11435] "Carboplatin_Etoposide-Phosphate_Melphalan"                                                                                                                            
[11436] "SU5416_Thalidomide"                                                                                                                                                   
[11437] "Cisplatin_Epoetin-Alfa"                                                                                                                                               
[11438] "Doxorubicin_Etoposide_Ifosfamide_Vincristine"                                                                                                                         
[11439] "Cetuximab_Fluorouracil_Irinotecan_Leucovorin-Calcium"                                                                                                                 
[11440] "Monoclonal-antibody-Ch14-18_Sargramostim"                                                                                                                             
[11441] "Interleukin-2_Monoclonal-Antibody-Ch14-18"                                                                                                                            
[11442] "Carboplatin_Epirubicin"                                                                                                                                               
[11443] "Bevacizumab_Carboplatin_Paclitaxel"                                                                                                                                   
[11444] "Dexamethasone_Isotretinoin"                                                                                                                                           
[11445] "Docetaxel_Exisulind"                                                                                                                                                  
[11446] "Epirubicin_Irinotecan"                                                                                                                                                
[11447] "Carboplatin_Squalamine-Lactate"                                                                                                                                       
[11448] "Flutamide_Toremifene"                                                                                                                                                 
[11449] "Cisplatin_Fluorouracil_G17DT"                                                                                                                                         
[11450] "Eflornithine_Triamcinolone"                                                                                                                                           
[11451] "Autologous-Lymphocytes_Interleukin-2_Sargramostim"                                                                                                                    
[11452] "Fluorouracil_Irinotecan_Leucovorin-Calcium_SU5416"                                                                                                                    
[11453] "Cyclophosphamide_Doxorubicin_Leucovorin-Calcium_Methotrexate_Prednisone_Vincristine"                                                                                  
[11454] "Cyclophosphamide_Doxorubicin_Leucovorin-Calcium_Methotrexate_Prednisone_Rituximab_Vincristine"                                                                        
[11455] "Interleukin-2_Montanide-ISA-51_Telomerase_540-548-Peptide-Vaccine"                                                                                                    
[11456] "Carboplatin_Docetaxel_Trastuzumab"                                                                                                                                    
[11457] "Cisplatin_Docetaxel_Trastuzumab"                                                                                                                                      
[11458] "Bevacizumab_Docetaxel_Doxorubicin"                                                                                                                                    
[11459] "Carboplatin_Cisplatin-epinephrine_Paclitaxel"                                                                                                                         
[11460] "Anastrozole_Trastuzumab"                                                                                                                                              
[11461] "Pentoxifylline_Vitamin-E"                                                                                                                                             
[11462] "Cyclophosphamide_Cytarabine_Mercaptopurine_Methotrexate_Pegaspargase_Vincristine"                                                                                     
[11463] "Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Methotrexate_Pegaspargase_Thioguanine_Vincristine"                                                              
[11464] "EGFR-Antisense-DNA_Sargramostim"                                                                                                                                      
[11465] "EGFR-Antisense-DNA_Keyhole-Limpet-Hemocyanin"                                                                                                                         
[11466] "Calcium-Citrate_Cholecalciferol"                                                                                                                                      
[11467] "Calcium-Gluconate_Cholecalciferol"                                                                                                                                    
[11468] "Calcium-Gluconate_Cholecalciferol_Zoledronate"                                                                                                                        
[11469] "Calcium-Citrate_Cholecalciferol_Zoledronate"                                                                                                                          
[11470] "Calcium-Carbonate_Cholecalciferol_Zoledronate"                                                                                                                        
[11471] "Etoposide_Ifosfamide_Imatinib-Mesylate_Methotrexate"                                                                                                                  
[11472] "Cyclophosphamide_Daunorubicin_Dexamethasone_Imatinib-Mesylate_Methotrexate_Pegaspargase_Vincristine"                                                                  
[11473] "Asparaginase_Cytarabine_Imatinib-mesylate"                                                                                                                            
[11474] "Cyclophosphamide_Dexamethasone_Etoposide_Imatinib-Mesylate_Mercaptopurine_Methotrexate_Vincristine"                                                                   
[11475] "Dexamethasone_Imatinib-Mesylate_Mercaptopurine_Methotrexate_Vincristine"                                                                                              
[11476] "BMS-214662_Trastuzumab"                                                                                                                                               
[11477] "Amifostine_Carboplatin_Fluorouracil_Paclitaxel"                                                                                                                       
[11478] "Montanide-ISA-51_Tyrosinase-related-protein-2"                                                                                                                        
[11479] "Interleukin-2_Montanide-ISA-51_Tyrosinase-Related-Protein-2"                                                                                                          
[11480] "Carboplatin_Flavopiridol"                                                                                                                                             
[11481] "Cyclophosphamide_Fludarabine_Oblimersen"                                                                                                                              
[11482] "Triapine_Cisplatin"                                                                                                                                                   
[11483] "Celecoxib_Cisplatin_Fluorouracil"                                                                                                                                     
[11484] "Bevacizumab_Fluorouracil_Hydroxyurea"                                                                                                                                 
[11485] "Doxorubicin_PS-341"                                                                                                                                                   
[11486] "Probenecid_10-Propargyl-10-Deazaaminopterin"                                                                                                                          
[11487] "Bevacizumab_Cytarabine_Idarubicin"                                                                                                                                    
[11488] "Cytarabine_Fludarabine_Isotretinoin"                                                                                                                                  
[11489] "Folic-Acid_Lometrexol_Paclitaxel"                                                                                                                                     
[11490] "Trastuzumab_ZD-1839"                                                                                                                                                  
[11491] "Doxorubicin_Strontium-Chloride-Sr-89"                                                                                                                                 
[11492] "Dacarbazine_Doxorubicin_Ifosfamide_SU5416"                                                                                                                            
[11493] "Cisplatin_Doxorubicin_Methotrexate_Trastuzumab"                                                                                                                       
[11494] "Cisplatin_Doxorubicin_Etoposide_Ifosfamide_Methotrexate_Trastuzumab"                                                                                                  
[11495] "Cisplatin_Etoposide_Ifosfamide_Prednisolone"                                                                                                                          
[11496] "Carboplatin_Irinotecan_Thalidomide"                                                                                                                                   
[11497] "Fluorouracil_Leucovorin-Calcium_Oxaliplatin_ZD-1839"                                                                                                                  
[11498] "BMS-247550_Estramustine"                                                                                                                                              
[11499] "Anti-Cytotoxic-T-lymphocyte-Associated-Antigen-4-Monoclonal-Antibody_gp100-Antigen_MART-1-Antigen_Montanide-ISA-51_Tyrosinase-Peptide"                                
[11500] "Docetaxel_Ifosfamide"                                                                                                                                                 
[11501] "Carboplatin_Temozolomide_Thiotepa"                                                                                                                                    
[11502] "Apolizumab_Rituximab"                                                                                                                                                 
[11503] "Bevacizumab_Fluorouracil_Leucovorin-Calcium_Oxaliplatin"                                                                                                              
[11504] "Cyclophosphamide_Doxorubicin_Tirapazamine"                                                                                                                            
[11505] "BCG_Monoclonal-Antibody-105AD7-Anti-Idiotype-Vaccine"                                                                                                                 
[11506] "Alum-Adjuvant_Monoclonal-Antibody-105AD7-Anti-Idiotype-Vaccine"                                                                                                       
[11507] "Pentostatin_Rituximab"                                                                                                                                                
[11508] "Bevacizumab_Interferon-Alfa"                                                                                                                                          
[11509] "Bleomycin_Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Vinblastine_Vincristine"                                                                                  
[11510] "Oxaliplatin_ZD-1839"                                                                                                                                                  
[11511] "Temozolomide_Vinorelbine"                                                                                                                                             
[11512] "Erlotinib_Gemcitabine"                                                                                                                                                
[11513] "Conjugated-Estrogens_Medroxyprogesterone"                                                                                                                             
[11514] "Isotretinoin_Monoclonal-antibody-Ch14-18_Sargramostim"                                                                                                                
[11515] "Interleukin-2_Isotretinoin_Monoclonal-Antibody-Ch14-18"                                                                                                               
[11516] "Fluorouracil_Irinotecan_Leucovorin-Calcium_ZD-1839"                                                                                                                   
[11517] "cBR96-Doxorubicin-Immunoconjugate_Docetaxel"                                                                                                                          
[11518] "Cytarabine_dexamethasone_methotrexate_pegaspargase_vincristine"                                                                                                       
[11519] "Cytarabine_Etoposide_Ifosfamide_Methotrexate_Vincristine"                                                                                                             
[11520] "Bevacizumab_Cisplatin_Gemcitabine"                                                                                                                                    
[11521] "Docetaxel_Estramustine_Thalidomide"                                                                                                                                   
[11522] "Alemtuzumab_Fludarabine_Melphalan"                                                                                                                                    
[11523] "Autologous-Dentritic-Cells_Fowlpox-CEA-TRICOM-Vaccine"                                                                                                                
[11524] "Carboplatin_Etoposide_PS-341"                                                                                                                                         
[11525] "Pegylated-Interferon-Alfa_Temozolomide"                                                                                                                               
[11526] "Bevacizumab_Docetaxel"                                                                                                                                                
[11527] "NY-ESO-1-Peptide-Vaccine_Sargramostim"                                                                                                                                
[11528] "Anti-CD3-x-Anti-HER-2-neu-BiSpecific-Monoclonal-Antibody_Autologous-Lymphocytes_Interleukin-2_Sargramostim"                                                           
[11529] "Busulfan_Fludarabine"                                                                                                                                                 
[11530] "Temozolomide_ZD-1839"                                                                                                                                                 
[11531] "Carboplatin_Cetuximab_Gemcitabine"                                                                                                                                    
[11532] "APC8015_Bevacizumab"                                                                                                                                                  
[11533] "ALVAC-CEA-B7-1-Vaccine_Fluorouracil_Irinotecan_Leucovorin-calcium"                                                                                                    
[11534] "ALVAC-CEA-B7-1-Vaccine_Fluorouracil_Irinotecan_Leucovorin-calcium_Tetanus-toxoid"                                                                                     
[11535] "Anti-Thymocyte-Globulin_Cyclophosphamide_Cytarabine"                                                                                                                  
[11536] "Carboplatin_Erlotinib_Paclitaxel"                                                                                                                                     
[11537] "BMS-247550_Carboplatin"                                                                                                                                               
[11538] "Bevacizumab_Paclitaxel"                                                                                                                                               
[11539] "Interleukin-12_Paclitaxel_Trastuzumab"                                                                                                                                
[11540] "Cytarabine_Imatinib-Mesylate"                                                                                                                                         
[11541] "Cyclophosphamide_Doxorubicin_Filgrastim_Prednisone_Rituximab_Vincristine"                                                                                             
[11542] "Bevacizumab_Gemcitabine"                                                                                                                                              
[11543] "Cytarabine_Gemtuzumab-Ozogamicin_Mitoxantrone"                                                                                                                        
[11544] "Asparaginase_Cytarabine_Gemtuzumab-ozogamicin"                                                                                                                        
[11545] "Carboplatin_Epoetin-alfa_Paclitaxel"                                                                                                                                  
[11546] "Carboplatin_PS-341"                                                                                                                                                   
[11547] "Docetaxel_R101933"                                                                                                                                                    
[11548] "Paclitaxel_R101933"                                                                                                                                                   
[11549] "Chinese-Herbs_Cyclophosphamide_Doxorubicin"                                                                                                                           
[11550] "Carboplatin_Paclitaxel_PS-341"                                                                                                                                        
[11551] "Dexamethasone_Doxorubicin"                                                                                                                                            
[11552] "Cyclophosphamide_Dexamethasone_Doxorubicin"                                                                                                                           
[11553] "Bexarotene_Cisplatin_Vinorelbine"                                                                                                                                     
[11554] "Doxorubicin-Hcl-Liposome_Ifosfamide"                                                                                                                                  
[11555] "Anti-Thymocyte-Globulin_Cyclophosphamide_Fludarabine_methylprednisolone"                                                                                              
[11556] "Capecitabine_Gemcitabine"                                                                                                                                             
[11557] "Autologous-Lymphocytes_Fluorouracil_Pegylated-Interferon-Alfa_Sargramostim"                                                                                           
[11558] "Celecoxib_Docetaxel"                                                                                                                                                  
[11559] "Isotretinoin_Monoclonal-antibody-Ch14-18"                                                                                                                             
[11560] "Carboplatin_Erlotinib"                                                                                                                                                
[11561] "Cisplatin_Erlotinib"                                                                                                                                                  
[11562] "Paclitaxel_PS-341"                                                                                                                                                    
[11563] "Montanide-ISA-51_PSA-Prostate-Cancer-Vaccine"                                                                                                                         
[11564] "_506U78_Asparaginase_Daunorubicin_Methotrexate_Prednisone_Vincristine"                                                                                                
[11565] "Irinotecan_UCN-01"                                                                                                                                                    
[11566] "Anti-Cytotoxic-T-lymphocyte-Associated-Antigen-4-Monoclonal-Antibody_gp100-Antigen_Montanide-ISA-51"                                                                  
[11567] "Alum-Adjuvant_gp100-Antigen_Interleukin-12_MART-1-Antigen_Montanide-ISA-51_Tyrosinase-Peptide"                                                                        
[11568] "gp100-Antigen_Interleukin-12_MART-1-Antigen_Montanide-ISA-51_Sargramostim_Tyrosinase-Peptide"                                                                         
[11569] "Bicalutamide_Exemestane"                                                                                                                                              
[11570] "Goserelin_Raloxifene"                                                                                                                                                 
[11571] "Dalteparin_Gemcitabine"                                                                                                                                               
[11572] "Megestrol_Omega-3-Fatty-Acids"                                                                                                                                        
[11573] "Cyclosporine_Hydroxychloroquine_Prednisone"                                                                                                                           
[11574] "Hydroxychloroquine_Prednisone_Tacrolimus"                                                                                                                             
[11575] "Bleomycin_Prednisolone_Rituximab_Vincristine"                                                                                                                         
[11576] "Autologous-Lymphocytes_gp100-Antigen_Interleukin-2_Montanide-ISA-51"                                                                                                  
[11577] "Detoxpc_Interleukin-2_RAS-Peptide-Cancer-Vaccine_Sargramostim"                                                                                                        
[11578] "Asparaginase_Leucovorin-Calcium_Methotrexate"                                                                                                                         
[11579] "Cytarabine_Etoposide_Rituximab"                                                                                                                                       
[11580] "Epoetin-Alfa_Filgrastim_Flt3-Ligand_Interleukin-3_Sargramostim"                                                                                                       
[11581] "Bleomycin_Cyclophosphamide_Idarubicin_Leucovorin-calcium_methotrexate_methylprednisolone_vincristine"                                                                 
[11582] "Allogeneic-Lymphocytes_Interleukin-2"                                                                                                                                 
[11583] "Fowlpox-Virus-Vaccine_gp100-Antigen_Interleukin-2"                                                                                                                    
[11584] "Alemtuzumab_Cyclophosphamide_Fludarabine"                                                                                                                             
[11585] "Capecitabine_Carboplatin_Epirubicin"                                                                                                                                  
[11586] "Gemtuzumab-Ozogamicin_Oblimersen"                                                                                                                                     
[11587] "Dexamethasone_Oblimersen"                                                                                                                                             
[11588] "Cisplatin_ZD-1839"                                                                                                                                                    
[11589] "Aspirin_Folic-Acid"                                                                                                                                                   
[11590] "Erlotinib_Trastuzumab"                                                                                                                                                
[11591] "Celecoxib_Eflornithine"                                                                                                                                               
[11592] "Dexamethasone_Thalidomide"                                                                                                                                            
[11593] "Bupropion_Nicotine"                                                                                                                                                   
[11594] "Etoposide_Filgrastim_Paclitaxel_Topotecan"                                                                                                                            
[11595] "Ethinyl-Estradiol_Norgestrel"                                                                                                                                         
[11596] "Cytarabine_Filgrastim_Mitoxantrone"                                                                                                                                   
[11597] "Corticotropin_Cyclophosphamide"                                                                                                                                       
[11598] "Cisplatin_Dacarbazine_Doxorubicin_Mitomycin_Sargramostim"                                                                                                             
[11599] "Interferon-Alfa_Temozolomide"                                                                                                                                         
[11600] "IDEC-Y2B8-Monoclonal-Antibody_Rituximab"                                                                                                                              
[11601] "Aspirin_Clopidogrel-Bisulfate"                                                                                                                                        
[11602] "Cytarabine_Dexamethasone_Ifosfamide_Leucovorin-Calcium_Methotrexate_Teniposide_Vincristine"                                                                           
[11603] "Cyclophosphamide_Dexamethasone_Doxorubicin_Leucovorin-Calcium_Methotrexate_Vincristine"                                                                               
[11604] "Bexarotene_Carboplatin_Paclitaxel"                                                                                                                                    
[11605] "Doxorubicin_Motexafin-Gadolinium"                                                                                                                                     
[11606] "Carboplatin_UCN-01"                                                                                                                                                   
[11607] "Isotretinoin_Sargramostim"                                                                                                                                            
[11608] "Cyclophosphamide_Fluorouracil_Methotrexate_Trastuzumab"                                                                                                               
[11609] "Cisplatin_Fluoxetine_Gemcitabine"                                                                                                                                     
[11610] "Beta-Glucan_Monoclonal-Antibody-3F8"                                                                                                                                  
[11611] "MUC-2-Globo-H-KLH-Conjugate-Vaccine_QS21"                                                                                                                             
[11612] "gp100-Antigen_Melan-A_Na17-A2-Antigen_Tyrosinase-Peptide"                                                                                                             
[11613] "MAGE-10-A2_Melan-A_NY-ESO-1-Peptide-Vaccine_Tyrosinase-Peptide"                                                                                                       
[11614] "MAGE-10-A2_Melan-A_NY-ESO-1-Peptide-Vaccine_Sargramostim_tyrosinase-Peptide"                                                                                          
[11615] "Cyclophosphamide_Pentostatin_Rituximab"                                                                                                                               
[11616] "CpG-7909_Trastuzumab"                                                                                                                                                 
[11617] "Cytarabine_Daunorubicin_Oblimersen"                                                                                                                                   
[11618] "BMS-275291_Zoledronate"                                                                                                                                               
[11619] "Irinotecan_Thalidomide"                                                                                                                                               
[11620] "Capecitabine_Celecoxib_ZD-1839"                                                                                                                                       
[11621] "Docetaxel_Sulindac"                                                                                                                                                   
[11622] "Docetaxel_Ketoconazole"                                                                                                                                               
[11623] "Cytarabine_Dexamethasone_Etoposide_Filgrastim_Ifosfamide_Leucovorin-Calcium_Methotrexate_Rituximab_Vincristine"                                                       
[11624] "Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Filgrastim_Leucovorin-Calcium_Methotrexate_Rituximab_Vincristine"                                               
[11625] "Cyclophosphamide_Dexrazoxane_Doxorubicin_Oblimersen"                                                                                                                  
[11626] "Flavopiridol_Trastuzumab"                                                                                                                                             
[11627] "Gemcitabine_UCN-01"                                                                                                                                                   
[11628] "Cyclophosphamide_Epirubicin_Gemcitabine_Paclitaxel"                                                                                                                   
[11629] "Cyclophosphamide_Epirubicin_Paclitaxel"                                                                                                                               
[11630] "Fowlpox-CEA-TRICOM-Vaccine_Sargramostim"                                                                                                                              
[11631] "Fowlpox-CEA-TRICOM-Vaccine_Fowlpox-Sargramostim"                                                                                                                      
[11632] "Ad5CMV-p53-Gene_Cisplatin_Fluorouracil"                                                                                                                               
[11633] "Ad5CMV-p53-Gene_Docetaxel"                                                                                                                                            
[11634] "Fowlpox-CEA-TRICOM-Vaccine_Vaccinia-CEA-TRICOM-Vaccine"                                                                                                               
[11635] "Fowlpox-CEA-TRICOM-Vaccine_Sargramostim_Vaccinia-CEA-TRICOM-Vaccine"                                                                                                  
[11636] "Cyclophosphamide_Dexamethasone_Doxorubicin_Rituximab_Vincristine"                                                                                                     
[11637] "Cytarabine_Leucovorin-Calcium_Methotrexate_Rituximab"                                                                                                                 
[11638] "Carboplatin_Exisulind_Gemcitabine"                                                                                                                                    
[11639] "Docetaxel_Filgrastim_Trastuzumab_Vinorelbine"                                                                                                                         
[11640] "Carboplatin_Etoposide_Exisulind"                                                                                                                                      
[11641] "Decitabine_FR901228"                                                                                                                                                  
[11642] "Docetaxel_Infliximab"                                                                                                                                                 
[11643] "Asparaginase_Cytarabine_Dexamethasone_Doxorubicin_methotrexate_thioguanine_vincristine"                                                                               
[11644] "CpG-7909_Rituximab"                                                                                                                                                   
[11645] "Lycopene_MultiVitamins"                                                                                                                                               
[11646] "Interferon-Alfa_Lamivudine_Zidovudine"                                                                                                                                
[11647] "Docetaxel_Hypericum-perforatum"                                                                                                                                       
[11648] "Cisplatin_Cyclophosphamide_Doxorubicin_Teniposide"                                                                                                                    
[11649] "Fluorouracil-Uracil_Leucovorin-Calcium"                                                                                                                               
[11650] "GW776_5-Fluorouracil-Combination-Tablet"                                                                                                                              
[11651] "Chemotherapy_Regimen"                                                                                                                                                 
[11652] "Anatomic_Structure_System_or_Substance"                                                                                                                               
[11653] "Lip"                                                                                                                                                                  
[11654] "External_Upper_Lip"                                                                                                                                                   
[11655] "External_Lower_Lip"                                                                                                                                                   
[11656] "External_Lip"                                                                                                                                                         
[11657] "Mucosa_of_the_Upper_Lip"                                                                                                                                              
[11658] "Mucosa_of_the_Lower_Lip"                                                                                                                                              
[11659] "Mucosa_of_the_Lip"                                                                                                                                                    
[11660] "Commissure_of_the_Lip"                                                                                                                                                
[11661] "Base_of_the_Tongue"                                                                                                                                                   
[11662] "Palate"                                                                                                                                                               
[11663] "Hard_Palate"                                                                                                                                                          
[11664] "Soft_Palate"                                                                                                                                                          
[11665] "Uvula"                                                                                                                                                                
[11666] "Submandibular_Gland"                                                                                                                                                  
[11667] "Sublingual_Salivary_Gland"                                                                                                                                            
[11668] "Tonsillar_Fossa"                                                                                                                                                      
[11669] "Tonsillar_Pillar"                                                                                                                                                     
[11670] "Vallecula"                                                                                                                                                            
[11671] "Anterior_Surface_of_the_Epiglottis"                                                                                                                                   
[11672] "Lateral_Wall_of_the_Oropharynx"                                                                                                                                       
[11673] "Posterior_Wall_of_the_Oropharynx"                                                                                                                                     
[11674] "Branchial_Cleft"                                                                                                                                                      
[11675] "Superior_Wall_of_the_Nasopharynx"                                                                                                                                     
[11676] "Posterior_Wall_of_the_Nasopharynx"                                                                                                                                    
[11677] "Lateral_Wall_of_the_Nasopharynx"                                                                                                                                      
[11678] "Anterior_Wall_of_the_Nasopharynx"                                                                                                                                     
[11679] "Hypopharynx"                                                                                                                                                          
[11680] "Postcricoid_Region"                                                                                                                                                   
[11681] "Hypopharyngeal_Aspect_of_Aryepiglottic_Fold"                                                                                                                          
[11682] "Posterior_Wall_of_the_Hypopharynx"                                                                                                                                    
[11683] "Cervical_Esophagus"                                                                                                                                                   
[11684] "Thoracic_Esophagus"                                                                                                                                                   
[11685] "Abdominal_Esophagus"                                                                                                                                                  
[11686] "Upper_Third_of_the_Esophagus"                                                                                                                                         
[11687] "Middle_Third_of_the_Esophagus"                                                                                                                                        
[11688] "Lower_Third_of_the_Esophagus"                                                                                                                                         
[11689] "Cardia"                                                                                                                                                               
[11690] "Fundus_of_the_Stomach"                                                                                                                                                
[11691] "Body_of_Stomach"                                                                                                                                                      
[11692] "Antrum_Pylori"                                                                                                                                                        
[11693] "Pylorus"                                                                                                                                                              
[11694] "Lesser_Curvature"                                                                                                                                                     
[11695] "Greater_Curvature"                                                                                                                                                    
[11696] "Duodenum"                                                                                                                                                             
[11697] "Meckel_Diverticulum"                                                                                                                                                  
[11698] "Ascending_Colon"                                                                                                                                                      
[11699] "Hepatic_Flexure"                                                                                                                                                      
[11700] "Splenic_Flexure"                                                                                                                                                      
[11701] "Descending_Colon"                                                                                                                                                     
[11702] "Head_of_the_Pancreas"                                                                                                                                                 
[11703] "Body_of_the_Pancreas"                                                                                                                                                 
[11704] "Tail_of_the_Pancreas"                                                                                                                                                 
[11705] "Pancreatic_Duct"                                                                                                                                                      
[11706] "Other_Specified_Parts_of_Pancreas"                                                                                                                                    
[11707] "Middle_Ear"                                                                                                                                                           
[11708] "Maxillary_Sinus"                                                                                                                                                      
[11709] "Ethmoid_Sinus"                                                                                                                                                        
[11710] "Frontal_Sinus"                                                                                                                                                        
[11711] "Sphenoid_Sinus"                                                                                                                                                       
[11712] "Supraglottis"                                                                                                                                                         
[11713] "Subglottis"                                                                                                                                                           
[11714] "Laryngeal_Cartilage"                                                                                                                                                  
[11715] "Lung_and_Bronchus"                                                                                                                                                    
[11716] "Main_Bronchus"                                                                                                                                                        
[11717] "Lung_Upper_Lobe"                                                                                                                                                      
[11718] "Middle_Lobe_of_the_Right_Lung"                                                                                                                                        
[11719] "Lung_Lower_Lobe"                                                                                                                                                      
[11720] "Bone_of_Skull_and_Face_and_Associated_Joints"                                                                                                                         
[11721] "Mandible"                                                                                                                                                             
[11722] "Skin_of_the_Lip"                                                                                                                                                      
[11723] "External_Ear"                                                                                                                                                         
[11724] "Skin_of_Other_and_Unspecified_Parts_of_Face"                                                                                                                          
[11725] "Skin_of_the_Scalp_and_Neck"                                                                                                                                           
[11726] "Skin_of_the_Trunk"                                                                                                                                                    
[11727] "Skin_of_the_Upper_Limb_and_Shoulder"                                                                                                                                  
[11728] "Skin_of_the_Lower_Limb_and_Hip"                                                                                                                                       
[11729] "Retroperitoneum"                                                                                                                                                      
[11730] "Nipple"                                                                                                                                                               
[11731] "Central_Portion_of_the_Breast"                                                                                                                                        
[11732] "Upper-inner_Quadrant_of_the_Breast"                                                                                                                                   
[11733] "Lower-inner_Quadrant_of_the_Breast"                                                                                                                                   
[11734] "Upper-outer_Quadrant_of_the_Breast"                                                                                                                                   
[11735] "Lower-outer_Quadrant_of_the_Breast"                                                                                                                                   
[11736] "Axillary_Tail_of_the_Breast"                                                                                                                                          
[11737] "Labium_Majus"                                                                                                                                                         
[11738] "Labium_Minus"                                                                                                                                                         
[11739] "Clitoris"                                                                                                                                                             
[11740] "Endocervix"                                                                                                                                                           
[11741] "Ectocervix"                                                                                                                                                           
[11742] "Cervix"                                                                                                                                                               
[11743] "Isthmus_Uteri"                                                                                                                                                        
[11744] "Endometrium"                                                                                                                                                          
[11745] "Myometrium"                                                                                                                                                           
[11746] "Fundus_Uteri"                                                                                                                                                         
[11747] "Corpus_Uteri"                                                                                                                                                         
[11748] "Other_and_Unspecified_Female_Genital_Organ"                                                                                                                           
[11749] "Broad_Ligament"                                                                                                                                                       
[11750] "Round_Ligament"                                                                                                                                                       
[11751] "Parametrium"                                                                                                                                                          
[11752] "Appendage_of_the_Uterus"                                                                                                                                              
[11753] "Other_Specified_Parts_of_Female_Genital_Organ"                                                                                                                        
[11754] "Prepuce"                                                                                                                                                              
[11755] "Glans_Penis"                                                                                                                                                          
[11756] "Body_of_the_Penis"                                                                                                                                                    
[11757] "Undescended_Testis"                                                                                                                                                   
[11758] "Descended_Testis"                                                                                                                                                     
[11759] "Epididymis"                                                                                                                                                           
[11760] "Spermatic_Cord"                                                                                                                                                       
[11761] "Other_Specified_Parts_of_Male_Genital_Organs"                                                                                                                         
[11762] "Bladder_Trigone"                                                                                                                                                      
[11763] "Dome_of_the_Bladder"                                                                                                                                                  
[11764] "Lateral_Wall_of_the_Bladder"                                                                                                                                          
[11765] "Anterior_Wall_of_the_Bladder"                                                                                                                                         
[11766] "Posterior_Wall_of_the_Bladder"                                                                                                                                        
[11767] "Bladder_Neck"                                                                                                                                                         
[11768] "Ureteric_Orifice"                                                                                                                                                     
[11769] "Urachus"                                                                                                                                                              
[11770] "Paraurethral_Gland"                                                                                                                                                   
[11771] "Eye_and_Adnexa"                                                                                                                                                       
[11772] "Conjunctiva"                                                                                                                                                          
[11773] "Cornea"                                                                                                                                                               
[11774] "Retina"                                                                                                                                                               
[11775] "Choroid"                                                                                                                                                              
[11776] "Ciliary_Body"                                                                                                                                                         
[11777] "Lacrimal_Gland"                                                                                                                                                       
[11778] "Orbit"                                                                                                                                                                
[11779] "Meninges"                                                                                                                                                             
[11780] "Cerebral_Meninges"                                                                                                                                                    
[11781] "Spinal_Meninges"                                                                                                                                                      
[11782] "Cerebral_Hemisphere"                                                                                                                                                  
[11783] "Frontal_Lobe"                                                                                                                                                         
[11784] "Temporal_Lobe"                                                                                                                                                        
[11785] "Parietal_Lobe_of_the_Brain"                                                                                                                                           
[11786] "Occipital_Lobe"                                                                                                                                                       
[11787] "Ventricle_Brain"                                                                                                                                                      
[11788] "Craniopharyngeal_Duct"                                                                                                                                                
[11789] "Head_and_Neck_Lymph_Node"                                                                                                                                             
[11790] "Intrathoracic_Lymph_Node"                                                                                                                                             
[11791] "Intra-abdominal_Lymph_Node"                                                                                                                                           
[11792] "Lymph_Node_of_Axilla_or_Arm"                                                                                                                                          
[11793] "Lymph_Node_of_Inguinal_Region_or_Leg"                                                                                                                                 
[11794] "Pelvic_Lymph_Node"                                                                                                                                                    
[11795] "Amnion"                                                                                                                                                               
[11796] "Bone"                                                                                                                                                                 
[11797] "Mammary_Gland"                                                                                                                                                        
[11798] "Areola"                                                                                                                                                               
[11799] "Breast_Fat_Pad"                                                                                                                                                       
[11800] "Mammary_Gland_Tissue"                                                                                                                                                 
[11801] "Myocardium"                                                                                                                                                           
[11802] "Artery"                                                                                                                                                               
[11803] "Cartilage"                                                                                                                                                            
[11804] "Connective_Tissue"                                                                                                                                                    
[11805] "Anal_Canal"                                                                                                                                                           
[11806] "Bile_Duct"                                                                                                                                                            
[11807] "Gallbladder"                                                                                                                                                          
[11808] "Gastrointestinal_System"                                                                                                                                              
[11809] "Large_Intestine"                                                                                                                                                      
[11810] "Vermiform_Appendix"                                                                                                                                                   
[11811] "Cecum"                                                                                                                                                                
[11812] "Colon"                                                                                                                                                                
[11813] "Right_Colon"                                                                                                                                                          
[11814] "Sigmoid_Colon"                                                                                                                                                        
[11815] "Transverse_Colon"                                                                                                                                                     
[11816] "Small_Intestine"                                                                                                                                                      
[11817] "Ileum"                                                                                                                                                                
[11818] "Jejunum"                                                                                                                                                              
[11819] "Esophagus"                                                                                                                                                            
[11820] "Rectum"                                                                                                                                                               
[11821] "Stomach"                                                                                                                                                              
[11822] "Liver"                                                                                                                                                                
[11823] "Pancreas"                                                                                                                                                             
[11824] "Ear"                                                                                                                                                                  
[11825] "Cochlea"                                                                                                                                                              
[11826] "Adrenal_Cortex"                                                                                                                                                       
[11827] "Adrenal_Medulla"                                                                                                                                                      
[11828] "Pineal_Gland"                                                                                                                                                         
[11829] "Pituitary_Gland"                                                                                                                                                      
[11830] "Thyroid_Gland"                                                                                                                                                        
[11831] "Eye"                                                                                                                                                                  
[11832] "Female_Reproductive_System"                                                                                                                                           
[11833] "Fallopian_Tube"                                                                                                                                                       
[11834] "Ovary"                                                                                                                                                                
[11835] "Uterus"                                                                                                                                                               
[11836] "Pregnant_Uterus"                                                                                                                                                      
[11837] "Vagina"                                                                                                                                                               
[11838] "Vulva"                                                                                                                                                                
[11839] "Penis"                                                                                                                                                                
[11840] "Prostate_Gland"                                                                                                                                                       
[11841] "Prostate_MF"                                                                                                                                                          
[11842] "Testis"                                                                                                                                                               
[11843] "Urinary_System"                                                                                                                                                       
[11844] "Bladder"                                                                                                                                                              
[11845] "Kidney"                                                                                                                                                               
[11846] "Ureter"                                                                                                                                                               
[11847] "Urethra"                                                                                                                                                              
[11848] "Head_and_Neck"                                                                                                                                                        
[11849] "Head"                                                                                                                                                                 
[11850] "Larynx"                                                                                                                                                               
[11851] "Oral_Cavity"                                                                                                                                                          
[11852] "Tongue"                                                                                                                                                               
[11853] "Nasopharynx"                                                                                                                                                          
[11854] "Nasal_Cavity"                                                                                                                                                         
[11855] "Pharynx"                                                                                                                                                              
[11856] "Salivary_Gland"                                                                                                                                                       
[11857] "Parotid_Gland"                                                                                                                                                        
[11858] "Trachea"                                                                                                                                                              
[11859] "Limb"                                                                                                                                                                 
[11860] "Lymphoreticular_Tissue"                                                                                                                                               
[11861] "Bone_Marrow"                                                                                                                                                          
[11862] "Spleen"                                                                                                                                                               
[11863] "Thymus_Gland"                                                                                                                                                         
[11864] "Blood"                                                                                                                                                                
[11865] "Muscle_Tissue"                                                                                                                                                        
[11866] "Striated_Muscle_Tissue"                                                                                                                                               
[11867] "Smooth_Muscle_Tissue"                                                                                                                                                 
[11868] "Central_Nervous_System"                                                                                                                                               
[11869] "Brain"                                                                                                                                                                
[11870] "Amygdala"                                                                                                                                                             
[11871] "Brain_Stem"                                                                                                                                                           
[11872] "Medulla_Oblongata"                                                                                                                                                    
[11873] "Cortex"                                                                                                                                                               
[11874] "Hippocampus"                                                                                                                                                          
[11875] "Cerebellum"                                                                                                                                                           
[11876] "Corpus_Callosum"                                                                                                                                                      
[11877] "Basal_Ganglia"                                                                                                                                                        
[11878] "Corpus_Striatum"                                                                                                                                                      
[11879] "Globus_Pallidus"                                                                                                                                                      
[11880] "Striatum"                                                                                                                                                             
[11881] "Caudate_Nucleus"                                                                                                                                                      
[11882] "Putamen"                                                                                                                                                              
[11883] "Substantia_Nigra"                                                                                                                                                     
[11884] "Subthalamic_Nucleus"                                                                                                                                                  
[11885] "Prosencephalon"                                                                                                                                                       
[11886] "Diencephalon"                                                                                                                                                         
[11887] "Epithalamus"                                                                                                                                                          
[11888] "Hypothalamus"                                                                                                                                                         
[11889] "Thalamus"                                                                                                                                                             
[11890] "Tectum_Mesencephali"                                                                                                                                                  
[11891] "Corpora_Quadrigemina"                                                                                                                                                 
[11892] "Dorsal_Root_Ganglion"                                                                                                                                                 
[11893] "Notochord"                                                                                                                                                            
[11894] "Spinal_Cord"                                                                                                                                                          
[11895] "Peripheral_Nervous_System"                                                                                                                                            
[11896] "Nerve"                                                                                                                                                                
[11897] "Sympathetic_Ganglion"                                                                                                                                                 
[11898] "Lung"                                                                                                                                                                 
[11899] "Pleural_Tissue"                                                                                                                                                       
[11900] "Skin"                                                                                                                                                                 
[11901] "Soft_Tissue"                                                                                                                                                          
[11902] "Adipose_Tissue"                                                                                                                                                       
[11903] "Synovial_Membrane"                                                                                                                                                    
[11904] "B-Lymphocyte"                                                                                                                                                         
[11905] "Basal_Cell"                                                                                                                                                           
[11906] "T-Lymphocyte"                                                                                                                                                         
[11907] "Astrocyte"                                                                                                                                                            
[11908] "Clear_Cell"                                                                                                                                                           
[11909] "Ductal_Epithelial_Cell"                                                                                                                                               
[11910] "Terminal_Ductal_Lobular_Unit"                                                                                                                                         
[11911] "Endothelium"                                                                                                                                                          
[11912] "Fibroblast"                                                                                                                                                           
[11913] "Granular_Cell"                                                                                                                                                        
[11914] "Large_Cell"                                                                                                                                                           
[11915] "Neuroendocrine_Cell"                                                                                                                                                  
[11916] "Plasma_Cell"                                                                                                                                                          
[11917] "Signet_Ring_Cell"                                                                                                                                                     
[11918] "Small_Cell"                                                                                                                                                           
[11919] "Spindle_Cell"                                                                                                                                                         
[11920] "Stroma"                                                                                                                                                               
[11921] "Intrathoracal"                                                                                                                                                        
[11922] "Intra-abdominal"                                                                                                                                                      
[11923] "Base_of_the_Skull"                                                                                                                                                    
[11924] "Clivus"                                                                                                                                                               
[11925] "Foramen_Magnum"                                                                                                                                                       
[11926] "Jugular_Foramen"                                                                                                                                                      
[11927] "Sella_Turcica"                                                                                                                                                        
[11928] "External_Acoustic_Meatus"                                                                                                                                             
[11929] "Internal_Ear"                                                                                                                                                         
[11930] "Eustachian_Tube"                                                                                                                                                      
[11931] "Internal_Auditory_Canal"                                                                                                                                              
[11932] "Tympanic_Membrane"                                                                                                                                                    
[11933] "Mastoid_Process"                                                                                                                                                      
[11934] "Buccal_Cavity"                                                                                                                                                        
[11935] "Buccal_Mucosa"                                                                                                                                                        
[11936] "Tooth"                                                                                                                                                                
[11937] "Mantle_Field"                                                                                                                                                         
[11938] "Cell"                                                                                                                                                                 
[11939] "Infratentorial_Brain"                                                                                                                                                 
[11940] "Mesencephalon"                                                                                                                                                        
[11941] "Pons_Varolii"                                                                                                                                                         
[11942] "Supratentorial_Brain"                                                                                                                                                 
[11943] "Sagittal_Sinus"                                                                                                                                                       
[11944] "Inferior_Sagittal_Sinus"                                                                                                                                              
[11945] "Superior_Sagittal_Sinus"                                                                                                                                              
[11946] "Intracranial_Nervous_System"                                                                                                                                          
[11947] "Intraspinal_Nervous_System"                                                                                                                                           
[11948] "Blastomere"                                                                                                                                                           
[11949] "Peripheral_Blood_Cell"                                                                                                                                                
[11950] "Platelet"                                                                                                                                                             
[11951] "Erythrocyte"                                                                                                                                                          
[11952] "Abnormal_Red_Blood_Cell"                                                                                                                                              
[11953] "Acanthocyte"                                                                                                                                                          
[11954] "Megaloblast"                                                                                                                                                          
[11955] "Spherocyte"                                                                                                                                                           
[11956] "Erythroid_Progenitor_Cell"                                                                                                                                            
[11957] "Erythroblast"                                                                                                                                                         
[11958] "Polychromatophilic_Erythrocyte"                                                                                                                                       
[11959] "Leukocyte"                                                                                                                                                            
[11960] "Granulocyte"                                                                                                                                                          
[11961] "Basophil"                                                                                                                                                             
[11962] "Eosinophil"                                                                                                                                                           
[11963] "Neutrophil"                                                                                                                                                           
[11964] "Non-Granular_Leukocyte"                                                                                                                                               
[11965] "Lymphocyte"                                                                                                                                                           
[11966] "Natural_Killer_Cell"                                                                                                                                                  
[11967] "CD4_Plus_T-Lymphocyte"                                                                                                                                                
[11968] "Helper-Inducer_T-Lymphocyte"                                                                                                                                          
[11969] "Type_1_Helper_Cell"                                                                                                                                                   
[11970] "Type_2_Helper_Cell"                                                                                                                                                   
[11971] "Suppressor-Inducer_T-Lymphocyte"                                                                                                                                      
[11972] "CD8_Plus_T-Lymphocyte"                                                                                                                                                
[11973] "Cytotoxic_T-Lymphocyte"                                                                                                                                               
[11974] "Suppressor-Effector_T-Lymphocyte"                                                                                                                                     
[11975] "Lymphocyte_Null"                                                                                                                                                      
[11976] "Tumor_Infiltrating_Lymphocyte"                                                                                                                                        
[11977] "Monocyte"                                                                                                                                                             
[11978] "Monocyte_Activated_Killer"                                                                                                                                            
[11979] "Myeloid_Cell"                                                                                                                                                         
[11980] "Bone_Marrow_Blood-Forming_Cell"                                                                                                                                       
[11981] "Hematopoietic_Stem_Cell"                                                                                                                                              
[11982] "Myeloid_Progenitor_Cell"                                                                                                                                              
[11983] "Megakaryocyte"                                                                                                                                                        
[11984] "Chromaffin_Cell"                                                                                                                                                      
[11985] "Connective_and_Soft_Tissue_Cell"                                                                                                                                      
[11986] "Adipocyte"                                                                                                                                                            
[11987] "Chondrocyte"                                                                                                                                                          
[11988] "Macrophage"                                                                                                                                                           
[11989] "Epithelioid_Cell"                                                                                                                                                     
[11990] "Foam_Cell"                                                                                                                                                            
[11991] "Foreign_Body_Giant_Cell"                                                                                                                                              
[11992] "Langhans_Cell"                                                                                                                                                        
[11993] "Histiocyte"                                                                                                                                                           
[11994] "Kupffer_Cell"                                                                                                                                                         
[11995] "Alveolar_Macrophage"                                                                                                                                                  
[11996] "Peritoneal_Macrophage"                                                                                                                                                
[11997] "Odontoblast"                                                                                                                                                          
[11998] "Osteoblast"                                                                                                                                                           
[11999] "Osteocyte"                                                                                                                                                            
[12000] "Osteoclast"                                                                                                                                                           
[12001] "Stromal_Cell"                                                                                                                                                         
[12002] "Theca_Cell"                                                                                                                                                           
[12003] "Endocrine_Cell_of_the_Gastrointestinal_System"                                                                                                                        
[12004] "Delta_Cell"                                                                                                                                                           
[12005] "Enterochromaffin_Cell"                                                                                                                                                
[12006] "Enterochromaffin-Like_Cell"                                                                                                                                           
[12007] "G-Cell"                                                                                                                                                               
[12008] "Epithelial_Cell"                                                                                                                                                      
[12009] "Ameloblast"                                                                                                                                                           
[12010] "Chief_Cell"                                                                                                                                                           
[12011] "Chromatophore"                                                                                                                                                        
[12012] "Melanophore"                                                                                                                                                          
[12013] "Dendritic_Cell"                                                                                                                                                       
[12014] "Langerhans_Cell"                                                                                                                                                      
[12015] "Enterocyte"                                                                                                                                                           
[12016] "Goblet_Cell"                                                                                                                                                          
[12017] "Granulosa_Cell"                                                                                                                                                       
[12018] "Hepatocyte"                                                                                                                                                           
[12019] "Keratinocyte"                                                                                                                                                         
[12020] "Supporting_Cell_of_Organ_of_Corti"                                                                                                                                    
[12021] "Melanocyte"                                                                                                                                                           
[12022] "Merkel_Cell"                                                                                                                                                          
[12023] "Paneth_Cell"                                                                                                                                                          
[12024] "Parietal_Cell"                                                                                                                                                        
[12025] "Sertoli_Cell"                                                                                                                                                         
[12026] "Eukaryotic_Cell"                                                                                                                                                      
[12027] "Germ_Cell"                                                                                                                                                            
[12028] "Egg"                                                                                                                                                                  
[12029] "Oocyte"                                                                                                                                                               
[12030] "Primary_Oocyte"                                                                                                                                                       
[12031] "Zygote"                                                                                                                                                               
[12032] "Spermatozoon"                                                                                                                                                         
[12033] "Head_of_the_Spermatozoon"                                                                                                                                             
[12034] "Spermatid"                                                                                                                                                            
[12035] "Spermatocyte"                                                                                                                                                         
[12036] "Spermatogonium"                                                                                                                                                       
[12037] "Giant_Cell"                                                                                                                                                           
[12038] "Islet_of_Langerhans"                                                                                                                                                  
[12039] "Leydig_Cell"                                                                                                                                                          
[12040] "Lutein_Cell"                                                                                                                                                          
[12041] "Antibody_Producing_Cell"                                                                                                                                              
[12042] "Muscle_Cell"                                                                                                                                                          
[12043] "Muscle_Fibers_Fast-Twitch"                                                                                                                                            
[12044] "Muscle_Fibers_Slow-Twitch"                                                                                                                                            
[12045] "Glial_Cell"                                                                                                                                                           
[12046] "Microglia"                                                                                                                                                            
[12047] "Neuropil"                                                                                                                                                             
[12048] "Oligodendroglia_Cell"                                                                                                                                                 
[12049] "Perineuronal_Satellite_Cell"                                                                                                                                          
[12050] "Schwann_Cell"                                                                                                                                                         
[12051] "Antigen_Presenting_Cell"                                                                                                                                              
[12052] "Follicular_Dendritic_Cell"                                                                                                                                            
[12053] "Neuron"                                                                                                                                                               
[12054] "Preganglionic_Autonomic_Fiber"                                                                                                                                        
[12055] "Interneuron"                                                                                                                                                          
[12056] "Amacrine_Cell"                                                                                                                                                        
[12057] "Myelinated_Nerve_Fiber"                                                                                                                                               
[12058] "Sensory_Neuron"                                                                                                                                                       
[12059] "Hair_Cell"                                                                                                                                                            
[12060] "Type_I_Hair_Cell"                                                                                                                                                     
[12061] "Type_II_Hair_Cell"                                                                                                                                                    
[12062] "Vestibular_Hair_Cell"                                                                                                                                                 
[12063] "Olfactory_Receptor_Neuron"                                                                                                                                            
[12064] "Photoreceptor_Cell"                                                                                                                                                   
[12065] "Photoreceptors_Invertebrate"                                                                                                                                          
[12066] "Photoreceptors_Vertebrate"                                                                                                                                            
[12067] "Cone"                                                                                                                                                                 
[12068] "Rod"                                                                                                                                                                  
[12069] "Rod_Outer_Segment"                                                                                                                                                    
[12070] "Posterior_Horn_Cell"                                                                                                                                                  
[12071] "Substantia_Gelatinosa"                                                                                                                                                
[12072] "Retinal_Ganglion_Cell"                                                                                                                                                
[12073] "Efferent_Neuron"                                                                                                                                                      
[12074] "Motor_Neuron"                                                                                                                                                         
[12075] "Anterior_Horn_Cell"                                                                                                                                                   
[12076] "Gamma_Motor_Neuron"                                                                                                                                                   
[12077] "Nitrergic_Neuron"                                                                                                                                                     
[12078] "Postganglionic_Autonomic_Fiber"                                                                                                                                       
[12079] "Postganglionic_Parasympathetic_Fiber"                                                                                                                                 
[12080] "Postganglionic_Sympathetic_Fiber"                                                                                                                                     
[12081] "Purkinje_s_Cell"                                                                                                                                                      
[12082] "Pyramidal_Cell"                                                                                                                                                       
[12083] "Oxyphil_Cell"                                                                                                                                                         
[12084] "APUD_Cell"                                                                                                                                                            
[12085] "Pericyte"                                                                                                                                                             
[12086] "Phagocytic_Cell"                                                                                                                                                      
[12087] "Prokaryotic_Cell"                                                                                                                                                     
[12088] "Protoplast"                                                                                                                                                           
[12089] "Reed-Sternberg_Cell"                                                                                                                                                  
[12090] "Spheroplast"                                                                                                                                                          
[12091] "Stem_Cell"                                                                                                                                                            
[12092] "Tumor_Stem_Cell"                                                                                                                                                      
[12093] "Abdominal_Cavity"                                                                                                                                                     
[12094] "Abducens_Nerve"                                                                                                                                                       
[12095] "Adrenal_Gland"                                                                                                                                                        
[12096] "Anterior_Chamber_of_the_Eye"                                                                                                                                          
[12097] "Anterior_Eye_Segment"                                                                                                                                                 
[12098] "Aorta"                                                                                                                                                                
[12099] "Aortic_Valve"                                                                                                                                                         
[12100] "Upper_Extremity"                                                                                                                                                      
[12101] "Arteriole"                                                                                                                                                            
[12102] "Autonomic_Nervous_System"                                                                                                                                             
[12103] "Axilla"                                                                                                                                                               
[12104] "Bartholin_s_Gland"                                                                                                                                                    
[12105] "Basilar_Artery"                                                                                                                                                       
[12106] "Intrahepatic_Bile_Duct"                                                                                                                                               
[12107] "Biliary_Tract"                                                                                                                                                        
[12108] "Blood_Vessel"                                                                                                                                                         
[12109] "Body_Region"                                                                                                                                                          
[12110] "Brachial_Artery"                                                                                                                                                      
[12111] "Brachial_Plexus"                                                                                                                                                      
[12112] "Bronchus"                                                                                                                                                             
[12113] "Bronchiole"                                                                                                                                                           
[12114] "Capillary"                                                                                                                                                            
[12115] "Cardiovascular_System"                                                                                                                                                
[12116] "Carotid_Artery"                                                                                                                                                       
[12117] "Carpal_Bone"                                                                                                                                                          
[12118] "Cauda_Equina"                                                                                                                                                         
[12119] "Cavernous_Sinus"                                                                                                                                                      
[12120] "Cerebral_Artery"                                                                                                                                                      
[12121] "Cerebrospinal_Fluid"                                                                                                                                                  
[12122] "Cervical_Vertebra"                                                                                                                                                    
[12123] "Choroid_Plexus"                                                                                                                                                       
[12124] "Clavicle"                                                                                                                                                             
[12125] "Coccyx"                                                                                                                                                               
[12126] "Cochlear_Nerve"                                                                                                                                                       
[12127] "Common_Bile_Duct"                                                                                                                                                     
[12128] "Corneal_Stroma"                                                                                                                                                       
[12129] "Cranial_Nerve"                                                                                                                                                        
[12130] "Dermis"                                                                                                                                                               
[12131] "Diaphragm"                                                                                                                                                            
[12132] "Ectoderm"                                                                                                                                                             
[12133] "Endocrine_Gland"                                                                                                                                                      
[12134] "Endocrine_System"                                                                                                                                                     
[12135] "Endoderm"                                                                                                                                                             
[12136] "Corneal_Endothelium"                                                                                                                                                  
[12137] "Epidermis"                                                                                                                                                            
[12138] "Epiglottis"                                                                                                                                                           
[12139] "Epithelium"                                                                                                                                                           
[12140] "Ethmoid_Bone"                                                                                                                                                         
[12141] "Exocrine_Gland"                                                                                                                                                       
[12142] "Eyelid"                                                                                                                                                               
[12143] "Facial_Nerve"                                                                                                                                                         
[12144] "Femoral_Artery"                                                                                                                                                       
[12145] "Femoral_Vein"                                                                                                                                                         
[12146] "Femur"                                                                                                                                                                
[12147] "Fibula"                                                                                                                                                               
[12148] "Ganglion"                                                                                                                                                             
[12149] "Autonomic_Ganglion"                                                                                                                                                   
[12150] "Geniculate_Ganglion"                                                                                                                                                  
[12151] "Male_Reproductive_System"                                                                                                                                             
[12152] "Glossopharyngeal_Nerve"                                                                                                                                               
[12153] "Glottis"                                                                                                                                                              
[12154] "Gonad"                                                                                                                                                                
[12155] "Inguinal_Region"                                                                                                                                                      
[12156] "Heart"                                                                                                                                                                
[12157] "Cardiac_Atrium"                                                                                                                                                       
[12158] "Cardiac_Valve"                                                                                                                                                        
[12159] "Cardiac_Ventricle"                                                                                                                                                    
[12160] "Humerus"                                                                                                                                                              
[12161] "Hypoglossal_Nerve"                                                                                                                                                    
[12162] "Iliac_Artery"                                                                                                                                                         
[12163] "Iliac_Vein"                                                                                                                                                           
[12164] "Immune_System"                                                                                                                                                        
[12165] "Intestine"                                                                                                                                                            
[12166] "Iris"                                                                                                                                                                 
[12167] "Jugular_Vein"                                                                                                                                                         
[12168] "Renal_Cortex"                                                                                                                                                         
[12169] "Renal_Medulla"                                                                                                                                                        
[12170] "Natural_Killer_Cell_Retired"                                                                                                                                          
[12171] "Lower_Extremity"                                                                                                                                                      
[12172] "Crystalline_Lens"                                                                                                                                                     
[12173] "Lumbar_Vertebra"                                                                                                                                                      
[12174] "Lymph_Node"                                                                                                                                                           
[12175] "Lymphatic_System"                                                                                                                                                     
[12176] "Mast_Cell"                                                                                                                                                            
[12177] "Mediastinum"                                                                                                                                                          
[12178] "Membrane"                                                                                                                                                             
[12179] "Mesoderm"                                                                                                                                                             
[12180] "Metacarpal_Bone"                                                                                                                                                      
[12181] "Metatarsal_Bone"                                                                                                                                                      
[12182] "Mitral_Valve"                                                                                                                                                         
[12183] "Musculoskeletal_System"                                                                                                                                               
[12184] "Nervous_System"                                                                                                                                                       
[12185] "Nose"                                                                                                                                                                 
[12186] "Occipital_Bone"                                                                                                                                                       
[12187] "Oculomotor_Nerve"                                                                                                                                                     
[12188] "Olfactory_Nerve"                                                                                                                                                      
[12189] "Optic_Disc"                                                                                                                                                           
[12190] "Optic_Nerve"                                                                                                                                                          
[12191] "Oropharynx"                                                                                                                                                           
[12192] "Paranasal_Sinus"                                                                                                                                                      
[12193] "Parasympathetic_Nervous_System"                                                                                                                                       
[12194] "Parathyroid_Gland"                                                                                                                                                    
[12195] "Parietal_Bone"                                                                                                                                                        
[12196] "Pelvis"                                                                                                                                                               
[12197] "Peripheral_Nerve"                                                                                                                                                     
[12198] "Peritoneal_Cavity"                                                                                                                                                    
[12199] "Peritoneum"                                                                                                                                                           
[12200] "Peyer_s_Patch"                                                                                                                                                        
[12201] "Anterior_Lobe_of_the_Pituitary_Gland"                                                                                                                                 
[12202] "Posterior_Lobe_of_the_Pituitary_Gland"                                                                                                                                
[12203] "Pulmonary_Artery"                                                                                                                                                     
[12204] "Pulmonary_Valve"                                                                                                                                                      
[12205] "Pulmonary_Vein"                                                                                                                                                       
[12206] "Radius_Bone"                                                                                                                                                          
[12207] "Renal_Artery"                                                                                                                                                         
[12208] "Respiratory_System"                                                                                                                                                   
[12209] "Reticuloendothelial_System"                                                                                                                                           
[12210] "Retroperitoneal_Space"                                                                                                                                                
[12211] "Rib"                                                                                                                                                                  
[12212] "Scapula"                                                                                                                                                              
[12213] "Sclera"                                                                                                                                                               
[12214] "Scrotum"                                                                                                                                                              
[12215] "Lunate_Bone"                                                                                                                                                          
[12216] "Seminal_Vesicle"                                                                                                                                                      
[12217] "Skeletal_System"                                                                                                                                                      
[12218] "Skull"                                                                                                                                                                
[12219] "Sphenoid_Bone"                                                                                                                                                        
[12220] "Spinal_Nerve_Root"                                                                                                                                                    
[12221] "Spinal_Nerve"                                                                                                                                                         
[12222] "Sternum"                                                                                                                                                              
[12223] "Subclavian_Vein"                                                                                                                                                      
[12224] "Sympathetic_Nervous_System"                                                                                                                                           
[12225] "Tarsal_Bone"                                                                                                                                                          
[12226] "Temporal_Bone"                                                                                                                                                        
[12227] "Thoracic_Vertebra"                                                                                                                                                    
[12228] "Thorax"                                                                                                                                                               
[12229] "Tibia"                                                                                                                                                                
[12230] "Tissue"                                                                                                                                                               
[12231] "Tonsil"                                                                                                                                                               
[12232] "Trabecular_Meshwork"                                                                                                                                                  
[12233] "Transplanted_Bone_Marrow"                                                                                                                                             
[12234] "Tricuspid_Valve"                                                                                                                                                      
[12235] "Trigeminal_Nerve"                                                                                                                                                     
[12236] "Trigeminal_Nucleus"                                                                                                                                                   
[12237] "Trochlear_Nerve"                                                                                                                                                      
[12238] "Ulna"                                                                                                                                                                 
[12239] "Genitourinary_System"                                                                                                                                                 
[12240] "Uvea"                                                                                                                                                                 
[12241] "Vagus_Nerve"                                                                                                                                                          
[12242] "Vas_Deferens"                                                                                                                                                         
[12243] "Vein"                                                                                                                                                                 
[12244] "Inferior_Vena_Cava"                                                                                                                                                   
[12245] "Superior_Vena_Cava"                                                                                                                                                   
[12246] "Vena_Cava"                                                                                                                                                            
[12247] "Venule"                                                                                                                                                               
[12248] "Vertebral_Artery"                                                                                                                                                     
[12249] "Vestibular_Nerve"                                                                                                                                                     
[12250] "Vestibular_Nucleus"                                                                                                                                                   
[12251] "Vocal_Cord"                                                                                                                                                           
[12252] "Corneoscleral_Limbus"                                                                                                                                                 
[12253] "Tibial_Artery"                                                                                                                                                        
[12254] "Anterior_Tibial_Artery"                                                                                                                                               
[12255] "Posterior_Tibial_Artery"                                                                                                                                              
[12256] "Third_Ventricle_of_Brain"                                                                                                                                             
[12257] "Fourth_Ventricle_of_the_Brain"                                                                                                                                        
[12258] "Anterior_Cerebral_Artery"                                                                                                                                             
[12259] "Middle_Cerebral_Artery"                                                                                                                                               
[12260] "Posterior_Cerebral_Artery"                                                                                                                                            
[12261] "Conus_Medullaris"                                                                                                                                                     
[12262] "Anterior_Spinal_Artery"                                                                                                                                               
[12263] "Lateral_Ventricle"                                                                                                                                                    
[12264] "Nucleus_Ambiguus"                                                                                                                                                     
[12265] "Abducens_Nucleus"                                                                                                                                                     
[12266] "Cochlear_Nuclei"                                                                                                                                                      
[12267] "Radial_Artery"                                                                                                                                                        
[12268] "Ulnar_Artery"                                                                                                                                                         
[12269] "Pleural_Cavity"                                                                                                                                                       
[12270] "Reproductive_System"                                                                                                                                                  
[12271] "Skin_Graft"                                                                                                                                                           
[12272] "Coronary_Artery"                                                                                                                                                      
[12273] "Cervical"                                                                                                                                                             
[12274] "Lumbar_Plexus"                                                                                                                                                        
[12275] "Sacral_Plexus"                                                                                                                                                        
[12276] "Reactive_Lymphocyte"                                                                                                                                                  
[12277] "Squamous_Epithelium"                                                                                                                                                  
[12278] "Squamous_Cell"                                                                                                                                                        
[12279] "Stratum_Spinosum"                                                                                                                                                     
[12280] "Female_Breast"                                                                                                                                                        
[12281] "Vertebral_Body"                                                                                                                                                       
[12282] "Sacral_Vertebra"                                                                                                                                                      
[12283] "Scaphoid_Bone"                                                                                                                                                        
[12284] "Pisiform_Bone"                                                                                                                                                        
[12285] "Capitate_Bone"                                                                                                                                                        
[12286] "Trapezial_Bone"                                                                                                                                                       
[12287] "Triangular_Bone"                                                                                                                                                      
[12288] "Trapezoid_Bone"                                                                                                                                                       
[12289] "Hamate_Bone"                                                                                                                                                          
[12290] "Phalanx_of_the_Hand"                                                                                                                                                  
[12291] "Proximal_Phalanx_of_the_Hand"                                                                                                                                         
[12292] "Middle_Phalanx_of_the_Hand"                                                                                                                                           
[12293] "Distal_Phalanx_of_the_Hand"                                                                                                                                           
[12294] "Endothelial_Cell"                                                                                                                                                     
[12295] "Transitional_Cell"                                                                                                                                                    
[12296] "Alveolar_Epithelium"                                                                                                                                                  
[12297] "Right_Atrium"                                                                                                                                                         
[12298] "Left_Atrium"                                                                                                                                                          
[12299] "Right_Ventricle"                                                                                                                                                      
[12300] "Left_Ventricle"                                                                                                                                                       
[12301] "Left_Coronary_Artery"                                                                                                                                                 
[12302] "Diagonal_Branch_of_Descending_Branch_of_Left_Coronary_Artery"                                                                                                         
[12303] "Circumflex_Branch_of_the_Left_Coronary_Artery"                                                                                                                        
[12304] "Right_Coronary_Artery"                                                                                                                                                
[12305] "Posterior_Spinal_Artery"                                                                                                                                              
[12306] "Venous_Sinus"                                                                                                                                                         
[12307] "Cardiac_Vein"                                                                                                                                                         
[12308] "Great_Cardiac_Vein"                                                                                                                                                   
[12309] "Middle_Cardiac_Vein"                                                                                                                                                  
[12310] "Small_Cardiac_Vein"                                                                                                                                                   
[12311] "Coronary_Vein"                                                                                                                                                        
[12312] "Brachial_Vein"                                                                                                                                                        
[12313] "Urothelium"                                                                                                                                                           
[12314] "Renal_Capsule"                                                                                                                                                        
[12315] "Renal_Pyramid"                                                                                                                                                        
[12316] "Renal_Pelvis"                                                                                                                                                         
[12317] "Visual_System"                                                                                                                                                        
[12318] "Auditory_System"                                                                                                                                                      
[12319] "Falx_Cerebri"                                                                                                                                                         
[12320] "Central_Canal"                                                                                                                                                        
[12321] "Cervical_Spinal_Cord"                                                                                                                                                 
[12322] "Cervical_Spinal_Nerve_Root"                                                                                                                                           
[12323] "Thoracic_Spinal_Cord"                                                                                                                                                 
[12324] "Lumbar_Spinal_Cord"                                                                                                                                                   
[12325] "Sacral_Spinal_Cord"                                                                                                                                                   
[12326] "Oculomotor_Nucleus"                                                                                                                                                   
[12327] "Facial_Nerve_Nucleus"                                                                                                                                                 
[12328] "Hypoglossal_Nucleus"                                                                                                                                                  
[12329] "Posterior_Chamber_of_the_Eye"                                                                                                                                         
[12330] "Palpebral_Conjunctiva"                                                                                                                                                
[12331] "Bulbar_Conjunctiva"                                                                                                                                                   
[12332] "Supraclavicular_Lymph_Node"                                                                                                                                           
[12333] "Axillary_Lymph_Node"                                                                                                                                                  
[12334] "Thoracic_Cavity"                                                                                                                                                      
[12335] "Posterior_Eye_Segment"                                                                                                                                                
[12336] "Integumentary_System"                                                                                                                                                 
[12337] "Other_Unique_Body_System"                                                                                                                                             
[12338] "Hematopoietic_System"                                                                                                                                                 
[12339] "Mucosa-Associated_Lymphoid_Tissue"                                                                                                                                    
[12340] "Spinal_Accessory_Nerve"                                                                                                                                               
[12341] "Caco-2_Cell"                                                                                                                                                          
[12342] "Abnormal_Cell"                                                                                                                                                        
[12343] "Atypical_Lymphoblast"                                                                                                                                                 
[12344] "Small_Cleaved_Cell"                                                                                                                                                   
[12345] "Micromegakaryocyte"                                                                                                                                                   
[12346] "Malignant_Cell"                                                                                                                                                       
[12347] "Blast_Cell"                                                                                                                                                           
[12348] "Organ_System"                                                                                                                                                         
[12349] "EBV-Specific_Cytotoxic_T-Lymphocyte"                                                                                                                                  
[12350] "Large_Granular_Lymphocyte"                                                                                                                                            
[12351] "Neoplastic_Cell"                                                                                                                                                      
[12352] "Supratentorial"                                                                                                                                                       
[12353] "Lumbar_Spinal_Nerve_Root"                                                                                                                                             
[12354] "Sacral_Spinal_Nerve_Root"                                                                                                                                             
[12355] "Thoracic_Spinal_Nerve_Root"                                                                                                                                           
[12356] "Renal_Calyx"                                                                                                                                                          
[12357] "Corneal_Epithelium"                                                                                                                                                   
[12358] "Nerve_Plexus"                                                                                                                                                         
[12359] "Intrapulmonary_Bronchus"                                                                                                                                              
[12360] "Meningeal"                                                                                                                                                            
[12361] "Xenograft"                                                                                                                                                            
[12362] "Vertebra"                                                                                                                                                             
[12363] "Dorsal_Motor_Nucleus"                                                                                                                                                 
[12364] "Embryonic_Stem_Cell"                                                                                                                                                  
[12365] "Gut_Associated_Lymphoid_Tissue"                                                                                                                                       
[12366] "Mammary_Epithelium"                                                                                                                                                   
[12367] "Peripheral_Blood_Lymphocyte"                                                                                                                                          
[12368] "Autologous_Lymphocyte"                                                                                                                                                
[12369] "Autologous_Tumor_Cell"                                                                                                                                                
[12370] "Coactivated_T-Cell"                                                                                                                                                   
[12371] "Intracarotid"                                                                                                                                                         
[12372] "Intrathecal_Space"                                                                                                                                                    
[12373] "Medial_Supraclavicular_Lymph_Node"                                                                                                                                    
[12374] "Neuroendocrine_System"                                                                                                                                                
[12375] "Peripheral_Blood_Stem_Cell"                                                                                                                                           
[12376] "Sentinel_Lymph_Node"                                                                                                                                                  
[12377] "Duct"                                                                                                                                                                 
[12378] "Somatic_Cell"                                                                                                                                                         
[12379] "Embryonic_Tissue"                                                                                                                                                     
[12380] "Splenocyte"                                                                                                                                                           
[12381] "Upper_Aerodigestive_Passage"                                                                                                                                          
[12382] "Nervous_System_Fluids_and_Secretions"                                                                                                                                 
[12383] "Peripheral_Blood_Mononuclear_Cell"                                                                                                                                    
[12384] "Nervous_System_Ear"                                                                                                                                                   
[12385] "Neuro-Ocular_System"                                                                                                                                                  
[12386] "Exocrine_System"                                                                                                                                                      
[12387] "Mammalian_Cell"                                                                                                                                                       
[12388] "Human_Breast_Cancer_Cell"                                                                                                                                             
[12389] "Liver_Stem_Cell"                                                                                                                                                      
[12390] "Trachea_and_Bronchus"                                                                                                                                                 
[12391] "Clonogen"                                                                                                                                                             
[12392] "Gut_Epithelium"                                                                                                                                                       
[12393] "Connective_and_Soft_Tissue"                                                                                                                                           
[12394] "Genital_System_Female_Other"                                                                                                                                          
[12395] "Genital_System_Male_Other"                                                                                                                                            
[12396] "Ascending_Spinal_Cord_Tract"                                                                                                                                          
[12397] "Tumor-Associated_Vasculature"                                                                                                                                         
[12398] "Descending_Spinal_Cord_Tract"                                                                                                                                         
[12399] "Pontine_Base"                                                                                                                                                         
[12400] "Breast"                                                                                                                                                               
[12401] "Peripheral_Nerve_Sheath"                                                                                                                                              
[12402] "Cervicomedullary_Junction"                                                                                                                                            
[12403] "Supratentorial_Nervous_System"                                                                                                                                        
[12404] "Infratentorial_Nervous_System"                                                                                                                                        
[12405] "Premalignant_Cell"                                                                                                                                                    
[12406] "Pluripotent_Stem_Cell"                                                                                                                                                
[12407] "Totipotent_Stem_Cell"                                                                                                                                                 
[12408] "Atypical_Mononuclear_Cell"                                                                                                                                            
[12409] "Intracranial_Artery"                                                                                                                                                  
[12410] "Graft"                                                                                                                                                                
[12411] "Bone_of_the_Lower_Extremity"                                                                                                                                          
[12412] "Bone_of_the_Upper_Extremity"                                                                                                                                          
[12413] "Interval_Lymph_Node"                                                                                                                                                  
[12414] "Neural_Stem_Cell"                                                                                                                                                     
[12415] "Alveolus"                                                                                                                                                             
[12416] "Caruncle"                                                                                                                                                             
[12417] "Cybrid"                                                                                                                                                               
[12418] "Episclera"                                                                                                                                                            
[12419] "Lobule"                                                                                                                                                               
[12420] "Neuroblast"                                                                                                                                                           
[12421] "Splenic_Red_Pulp"                                                                                                                                                     
[12422] "Splenic_White_Pulp"                                                                                                                                                   
[12423] "Thymocyte"                                                                                                                                                            
[12424] "Spinal_Cord_Tract"                                                                                                                                                    
[12425] "Vestibulocochlear_Nerve"                                                                                                                                              
[12426] "Body_Space"                                                                                                                                                           
[12427] "Vertebral_Column"                                                                                                                                                     
[12428] "Major_Salivary_Gland"                                                                                                                                                 
[12429] "Rhabdomyocyte"                                                                                                                                                        
[12430] "Smooth_Muscle_Tissue_Cell"                                                                                                                                            
[12431] "Cardiocyte"                                                                                                                                                           
[12432] "Ependymocyte"                                                                                                                                                         
[12433] "Endocardium"                                                                                                                                                          
[12434] "Pericardium"                                                                                                                                                          
[12435] "Specialized_Epithelial_Cell"                                                                                                                                          
[12436] "Gross_Anatomy_Concepts"                                                                                                                                               
[12437] "Lymphokine-Activated_Killer_Cell"                                                                                                                                     
[12438] "Histology_Concepts"                                                                                                                                                   
[12439] "Brunner_s_Gland"                                                                                                                                                      
[12440] "Ampulla_of_Vater"                                                                                                                                                     
[12441] "Lymphoid_Blood-Forming_Cell"                                                                                                                                          
[12442] "Lymphoblast"                                                                                                                                                          
[12443] "Monoblast"                                                                                                                                                            
[12444] "Myeloblast"                                                                                                                                                           
[12445] "Female_Genital_Organ"                                                                                                                                                 
[12446] "Male_Genital_Organ"                                                                                                                                                   
[12447] "Organ"                                                                                                                                                                
[12448] "Eye_Part"                                                                                                                                                             
[12449] "Breast-Related_Entity"                                                                                                                                                
[12450] "Mouth_Part"                                                                                                                                                           
[12451] "Skin_Part"                                                                                                                                                            
[12452] "Heart_Part"                                                                                                                                                           
[12453] "Pancreas_Part"                                                                                                                                                        
[12454] "Stomach_Part"                                                                                                                                                         
[12455] "Intestine_Part"                                                                                                                                                       
[12456] "Esophagus_Part"                                                                                                                                                       
[12457] "Biliary_Tract_Part"                                                                                                                                                   
[12458] "Endocrine_System_Part"                                                                                                                                                
[12459] "Gonad_Part"                                                                                                                                                           
[12460] "Brain_Part"                                                                                                                                                           
[12461] "Exocrine_System_Part"                                                                                                                                                 
[12462] "Immune_System_Part"                                                                                                                                                   
[12463] "Lymphatic_System_Part"                                                                                                                                                
[12464] "Urinary_System_Part"                                                                                                                                                  
[12465] "Stomatognathic_System_Part"                                                                                                                                           
[12466] "Respiratory_System_Part"                                                                                                                                              
[12467] "Male_Reproductive_System_Part"                                                                                                                                        
[12468] "Female_Reproductive_System_Part"                                                                                                                                      
[12469] "Nervous_System_Part"                                                                                                                                                  
[12470] "Body"                                                                                                                                                                 
[12471] "Organ_System_Part"                                                                                                                                                    
[12472] "Ear_Part"                                                                                                                                                             
[12473] "Joint"                                                                                                                                                                
[12474] "Tendon"                                                                                                                                                               
[12475] "Ligament"                                                                                                                                                             
[12476] "Seminiferous_Tubule"                                                                                                                                                  
[12477] "Nephron"                                                                                                                                                              
[12478] "Lymphoid_Tissue"                                                                                                                                                      
[12479] "Skeletal_Muscle_Tissue"                                                                                                                                               
[12480] "Hematopoietic_Tissue"                                                                                                                                                 
[12481] "Nervous_Tissue"                                                                                                                                                       
[12482] "Vascular_Endothelium"                                                                                                                                                 
[12483] "Embryonic_Cell"                                                                                                                                                       
[12484] "Secretory_Cell"                                                                                                                                                       
[12485] "Muscle"                                                                                                                                                               
[12486] "Reticular_Cell"                                                                                                                                                       
[12487] "Special_Sense_Organ_System"                                                                                                                                           
[12488] "Synovial_Cell"                                                                                                                                                        
[12489] "Sensory_Ganglion"                                                                                                                                                     
[12490] "Chromaffin_System"                                                                                                                                                    
[12491] "Back"                                                                                                                                                                 
[12492] "Neck"                                                                                                                                                                 
[12493] "Digestive_System"                                                                                                                                                     
[12494] "Sphincter_of_Oddi"                                                                                                                                                    
[12495] "Ileocecal_Valve"                                                                                                                                                      
[12496] "Solitary_Nucleus"                                                                                                                                                     
[12497] "Foot_Bone"                                                                                                                                                            
[12498] "Stomatognathic_System"                                                                                                                                                
[12499] "Cheek"                                                                                                                                                                
[12500] "Face"                                                                                                                                                                 
[12501] "Dentition"                                                                                                                                                            
[12502] "Facial_Muscle"                                                                                                                                                        
[12503] "Masseter_Muscle"                                                                                                                                                      
[12504] "Pharyngeal_Muscle"                                                                                                                                                    
[12505] "Bone_Tissue"                                                                                                                                                          
[12506] "Acinar_Cell"                                                                                                                                                          
[12507] "Ependyma"                                                                                                                                                             
[12508] "Neural_Pathway"                                                                                                                                                       
[12509] "Afferent_Pathway"                                                                                                                                                     
[12510] "Efferent_Pathway"                                                                                                                                                     
[12511] "Internal_Capsule"                                                                                                                                                     
[12512] "Medial_Forebrain_Bundle"                                                                                                                                              
[12513] "Perforant_Pathway"                                                                                                                                                    
[12514] "Alveolar_Wall"                                                                                                                                                        
[12515] "Capsule_of_the_Prostate"                                                                                                                                              
[12516] "Apex_of_the_Prostate"                                                                                                                                                 
[12517] "Base_of_the_Prostate"                                                                                                                                                 
[12518] "Anterior_Surface_of_the_Prostate"                                                                                                                                     
[12519] "Inferolateral_Surface_of_the_Prostate"                                                                                                                                
[12520] "Surface_of_the_Prostate"                                                                                                                                              
[12521] "Lateral_Lobe_of_the_Prostate"                                                                                                                                         
[12522] "Posterior_Lobe_of_the_Prostate"                                                                                                                                       
[12523] "Middle_Lobe_of_the_Prostate"                                                                                                                                          
[12524] "Posterior_Surface_of_the_Prostate"                                                                                                                                    
[12525] "Prostatic_Glandular_Tissue"                                                                                                                                           
[12526] "Mucosal_Tissue_of_Human_Prostate"                                                                                                                                     
[12527] "Orifice_of_Human_Prostatic_Duct"                                                                                                                                      
[12528] "Submucosal_Tissue_of_Human_Prostate"                                                                                                                                  
[12529] "Prostatic_Muscular_Tissue"                                                                                                                                            
[12530] "Prostatic_Portion_of_the_Male_Urethra"                                                                                                                                
[12531] "Prostatic_Duct"                                                                                                                                                       
[12532] "Prostatic_Epithelium"                                                                                                                                                 
[12533] "Prostatic_Stroma"                                                                                                                                                     
[12534] "Human_Veru_Montanum"                                                                                                                                                  
[12535] "Wall_of_Human_Prostatic_Duct"                                                                                                                                         
[12536] "Fascia"                                                                                                                                                               
[12537] "Macrocyte"                                                                                                                                                            
[12538] "Immature_Granulocyte"                                                                                                                                                 
[12539] "Promyelocyte"                                                                                                                                                         
[12540] "Myelocyte"                                                                                                                                                            
[12541] "Metamyelocyte"                                                                                                                                                        
[12542] "Band_Cell"                                                                                                                                                            
[12543] "Immature_Lymphocyte"                                                                                                                                                  
[12544] "Prolymphocyte"                                                                                                                                                        
[12545] "Immature_Monocyte"                                                                                                                                                    
[12546] "Promonocyte"                                                                                                                                                          
[12547] "Megakaryoblast"                                                                                                                                                       
[12548] "Memory_B_Cell"                                                                                                                                                        
[12549] "Epithelial_Reticular_Cell"                                                                                                                                            
[12550] "Immature_Platelet"                                                                                                                                                    
[12551] "_7p15-p14"                                                                                                                                                            
[12552] "_7q35"                                                                                                                                                                
[12553] "Proerythroblast"                                                                                                                                                      
[12554] "Basophilic_Erythroblast"                                                                                                                                              
[12555] "Polychromatophilic_Erythroblast"                                                                                                                                      
[12556] "Orthochromatophilic_Erythroblast"                                                                                                                                     
[12557] "_2q37"                                                                                                                                                                
[12558] "Xp11_23"                                                                                                                                                              
[12559] "_19q13_2-q13_3"                                                                                                                                                       
[12560] "_13q33"                                                                                                                                                               
[12561] "_16p13_3-p13_11"                                                                                                                                                      
[12562] "_3q22-q24"                                                                                                                                                            
[12563] "_7q11-q22"                                                                                                                                                            
[12564] "Ependymal_Cell"                                                                                                                                                       
[12565] "Mucus-Secreting_Cell"                                                                                                                                                 
[12566] "Clara_Cell"                                                                                                                                                           
[12567] "Squamous_Alveolar_Lining_Cell"                                                                                                                                        
[12568] "Epithelial_Receptor_Cell"                                                                                                                                             
[12569] "Type_I_Cell"                                                                                                                                                          
[12570] "Taste_Bud_Cell"                                                                                                                                                       
[12571] "Light_Cell"                                                                                                                                                           
[12572] "Type_III_Epithelial_Receptor_Cell"                                                                                                                                    
[12573] "Olfactory_Epithelial_Cell"                                                                                                                                            
[12574] "Olfactory_Cell"                                                                                                                                                       
[12575] "Supporting_Cell"                                                                                                                                                      
[12576] "Olfactory_Basal_Cell"                                                                                                                                                 
[12577] "Bipolar_Neuron"                                                                                                                                                       
[12578] "Ganglion_Cell"                                                                                                                                                        
[12579] "Receptor_Cell"                                                                                                                                                        
[12580] "Cuboidal_Cell"                                                                                                                                                        
[12581] "Columnar_Cell"                                                                                                                                                        
[12582] "Mesangial_Cell"                                                                                                                                                       
[12583] "Intercalated_Cell"                                                                                                                                                    
[12584] "Juxtaglomerular_Cell"                                                                                                                                                 
[12585] "Epicardium"                                                                                                                                                           
[12586] "Organ_Layer"                                                                                                                                                          
[12587] "Mucosa"                                                                                                                                                               
[12588] "Submucosa"                                                                                                                                                            
[12589] "Muscularis_Externa"                                                                                                                                                   
[12590] "Serosa"                                                                                                                                                               
[12591] "Hassall_s_Corpuscle"                                                                                                                                                  
[12592] "Meissner_Corpuscle"                                                                                                                                                   
[12593] "Vater-Pacini_Corpuscle"                                                                                                                                               
[12594] "Merkel_s_Corpuscle"                                                                                                                                                   
[12595] "Free_Nerve_Ending"                                                                                                                                                    
[12596] "Ruffinis_Corpuscle"                                                                                                                                                   
[12597] "Nociceptor"                                                                                                                                                           
[12598] "Pigment_Epithelium"                                                                                                                                                   
[12599] "Simple_Squamous_Epithelium"                                                                                                                                           
[12600] "Basilar_Membrane"                                                                                                                                                     
[12601] "Stratified_Squamous_Epithelium"                                                                                                                                       
[12602] "Pseudostratified_Columnar_Ciliated_Epithelium"                                                                                                                        
[12603] "Columnar_Epithelium"                                                                                                                                                  
[12604] "Endosteum"                                                                                                                                                            
[12605] "Periosteum"                                                                                                                                                           
[12606] "Taste_Bud_Basal_Cell"                                                                                                                                                 
[12607] "A-DNA"                                                                                                                                                                
[12608] "Protein_Sequence"                                                                                                                                                     
[12609] "Amniotic_Fluid"                                                                                                                                                       
[12610] "Epitopes"                                                                                                                                                             
[12611] "Aqueous_Humor"                                                                                                                                                        
[12612] "Basement_Membrane"                                                                                                                                                    
[12613] "Bile"                                                                                                                                                                 
[12614] "Antibody_Binding_Site"                                                                                                                                                
[12615] "Blood-Brain_Barrier"                                                                                                                                                  
[12616] "Bronchoalveolar_Lavage_Fluid"                                                                                                                                         
[12617] "Nucleolus"                                                                                                                                                            
[12618] "Nucleus"                                                                                                                                                              
[12619] "Centromere"                                                                                                                                                           
[12620] "Chloroplast"                                                                                                                                                          
[12621] "Chromatid"                                                                                                                                                            
[12622] "Chromatin"                                                                                                                                                            
[12623] "Chromosome"                                                                                                                                                           
[12624] "Human_Chromosome"                                                                                                                                                     
[12625] "Chromosome_1"                                                                                                                                                         
[12626] "Chromosome_10"                                                                                                                                                        
[12627] "Chromosome_11"                                                                                                                                                        
[12628] "Chromosome_12"                                                                                                                                                        
[12629] "Chromosome_13"                                                                                                                                                        
[12630] "Chromosome_14"                                                                                                                                                        
[12631] "Chromosome_15"                                                                                                                                                        
[12632] "Chromosome_16"                                                                                                                                                        
[12633] "Chromosome_17"                                                                                                                                                        
[12634] "Chromosome_18"                                                                                                                                                        
[12635] "Chromosome_19"                                                                                                                                                        
[12636] "Chromosome_2"                                                                                                                                                         
[12637] "Chromosome_20"                                                                                                                                                        
[12638] "Chromosome_21"                                                                                                                                                        
[12639] "Chromosome_22"                                                                                                                                                        
[12640] "Chromosome_3"                                                                                                                                                         
[12641] "Chromosome_4"                                                                                                                                                         
[12642] "Chromosome_5"                                                                                                                                                         
[12643] "Chromosome_6"                                                                                                                                                         
[12644] "Chromosome_7"                                                                                                                                                         
[12645] "Chromosome_8"                                                                                                                                                         
[12646] "Chromosome_9"                                                                                                                                                         
[12647] "Cytoplasm"                                                                                                                                                            
[12648] "Cytoskeleton"                                                                                                                                                         
[12649] "Satellite_DNA"                                                                                                                                                        
[12650] "Embryonic_Structure"                                                                                                                                                  
[12651] "Endoplasmic_Reticulum"                                                                                                                                                
[12652] "Exon"                                                                                                                                                                 
[12653] "Extracellular_Matrix"                                                                                                                                                 
[12654] "Exudate"                                                                                                                                                              
[12655] "Feces"                                                                                                                                                                
[12656] "Fetus"                                                                                                                                                                
[12657] "Body_Fluid_or_Substance"                                                                                                                                              
[12658] "Golgi_Apparatus"                                                                                                                                                      
[12659] "Haptens"                                                                                                                                                              
[12660] "Heterochromatin"                                                                                                                                                      
[12661] "Immunoglobulin_Constant_Region"                                                                                                                                       
[12662] "Immunoglobulin_Joining_Region"                                                                                                                                        
[12663] "Immunoglobulin_Switch_Region"                                                                                                                                         
[12664] "Immunoglobulin_Variable_Region"                                                                                                                                       
[12665] "Fab_Fragment"                                                                                                                                                         
[12666] "Immunoglobulin_Fc"                                                                                                                                                    
[12667] "Intermediate_Filament"                                                                                                                                                
[12668] "Intron"                                                                                                                                                               
[12669] "Glomerulus"                                                                                                                                                           
[12670] "Long_Terminal_Repeat"                                                                                                                                                 
[12671] "Lymph"                                                                                                                                                                
[12672] "Lysosome"                                                                                                                                                             
[12673] "Peroxisome"                                                                                                                                                           
[12674] "Actin_Filament"                                                                                                                                                       
[12675] "Microtubule"                                                                                                                                                          
[12676] "Breast_Milk"                                                                                                                                                          
[12677] "Mitochondrion"                                                                                                                                                        
[12678] "Mucus"                                                                                                                                                                
[12679] "Mullerian_Duct"                                                                                                                                                       
[12680] "Myelin_Sheath"                                                                                                                                                        
[12681] "Heart_Muscle"                                                                                                                                                         
[12682] "Neurofilament"                                                                                                                                                        
[12683] "Nuclear_Matrix"                                                                                                                                                       
[12684] "Nuclear_Membrane"                                                                                                                                                     
[12685] "Nuclear_Pore"                                                                                                                                                         
[12686] "Nucleolar_Organizer_Region"                                                                                                                                           
[12687] "Nucleosome"                                                                                                                                                           
[12688] "Cytoplasmic_Organelle"                                                                                                                                                
[12689] "Pancreatic_Secretion"                                                                                                                                                 
[12690] "t_9_22_q34_q11"                                                                                                                                                       
[12691] "Placenta"                                                                                                                                                             
[12692] "Lung_Surfactant"                                                                                                                                                      
[12693] "Ribosome"                                                                                                                                                             
[12694] "Saliva"                                                                                                                                                               
[12695] "Sebum"                                                                                                                                                                
[12696] "Semen"                                                                                                                                                                
[12697] "Sputum"                                                                                                                                                               
[12698] "Sweat"                                                                                                                                                                
[12699] "Synapse"                                                                                                                                                              
[12700] "Subcellular_Structure"                                                                                                                                                
[12701] "Urine"                                                                                                                                                                
[12702] "Vacuole"                                                                                                                                                              
[12703] "Chromosome_X"                                                                                                                                                         
[12704] "Chromosome_Y"                                                                                                                                                         
[12705] "Z-DNA"                                                                                                                                                                
[12706] "RGD_Motif"                                                                                                                                                            
[12707] "Euchromatin"                                                                                                                                                          
[12708] "Kringle_Domain"                                                                                                                                                       
[12709] "Leucine_Zipper"                                                                                                                                                       
[12710] "Open_Reading_Frame"                                                                                                                                                   
[12711] "TATA_Box"                                                                                                                                                             
[12712] "C2H2_Zinc_Finger"                                                                                                                                                     
[12713] "Telomere"                                                                                                                                                             
[12714] "Enhancer"                                                                                                                                                             
[12715] "Promoter"                                                                                                                                                             
[12716] "Repetitive_Sequence"                                                                                                                                                  
[12717] "DNA_Sequence"                                                                                                                                                         
[12718] "Umbilical_Cord_Blood"                                                                                                                                                 
[12719] "Mesenchyme"                                                                                                                                                           
[12720] "Secondary_Protein_Structure"                                                                                                                                          
[12721] "Protein_Structure"                                                                                                                                                    
[12722] "Pulmonary"                                                                                                                                                            
[12723] "Laryngeal"                                                                                                                                                            
[12724] "Cardiac"                                                                                                                                                              
[12725] "Gastric"                                                                                                                                                              
[12726] "Hepatic"                                                                                                                                                              
[12727] "Vaginal"                                                                                                                                                              
[12728] "Systemic"                                                                                                                                                             
[12729] "Vascular"                                                                                                                                                             
[12730] "Gap_Junction"                                                                                                                                                         
[12731] "Helix-Loop-Helix_Domain"                                                                                                                                              
[12732] "Proteasome"                                                                                                                                                           
[12733] "Epithelial"                                                                                                                                                           
[12734] "Cutaneous"                                                                                                                                                            
[12735] "Hair_Follicle"                                                                                                                                                        
[12736] "Transitional_Epithelium"                                                                                                                                              
[12737] "Gland"                                                                                                                                                                
[12738] "Nose_Nasal_Passages"                                                                                                                                                  
[12739] "Gastrointestinal_Fluid_or_Secretion"                                                                                                                                  
[12740] "Endometrial"                                                                                                                                                          
[12741] "Vitreous_Humor"                                                                                                                                                       
[12742] "Hematopoietic"                                                                                                                                                        
[12743] "Serum"                                                                                                                                                                
[12744] "Metaphase_Plate"                                                                                                                                                      
[12745] "Hemidesmosome"                                                                                                                                                        
[12746] "Caveola"                                                                                                                                                              
[12747] "Rough_Endoplasmic_Reticulum"                                                                                                                                          
[12748] "Outer_Mitochondrial_Membrane"                                                                                                                                         
[12749] "Inner_Mitochondrial_Membrane"                                                                                                                                         
[12750] "Bilateral"                                                                                                                                                            
[12751] "Tight_Junction"                                                                                                                                                       
[12752] "Minisatellite_Repeats"                                                                                                                                                
[12753] "Origin_of_Replication"                                                                                                                                                
[12754] "PA700_Regulatory_Module"                                                                                                                                              
[12755] "Germinal_Center"                                                                                                                                                      
[12756] "Microsatellite_Repeats"                                                                                                                                               
[12757] "SH2_Domain"                                                                                                                                                           
[12758] "SH3_Domain"                                                                                                                                                           
[12759] "Helix-Turn-Helix_Motif"                                                                                                                                               
[12760] "Immunoglobulin_Hypervariable_Region"                                                                                                                                  
[12761] "Immunoglobulin_Hinge_Region"                                                                                                                                          
[12762] "Topical"                                                                                                                                                              
[12763] "Stoma"                                                                                                                                                                
[12764] "Intravenous"                                                                                                                                                          
[12765] "Aspirate"                                                                                                                                                             
[12766] "Genital"                                                                                                                                                              
[12767] "Myeloid"                                                                                                                                                              
[12768] "Lymphocytic"                                                                                                                                                          
[12769] "Axillary"                                                                                                                                                             
[12770] "Intraperitoneal"                                                                                                                                                      
[12771] "Subcutaneous"                                                                                                                                                         
[12772] "Brain_Ventricle"                                                                                                                                                      
[12773] "Chromosome_Arm"                                                                                                                                                       
[12774] "Plasma"                                                                                                                                                               
[12775] "Gastrointestinal"                                                                                                                                                     
[12776] "Thoracic"                                                                                                                                                             
[12777] "Nuclear"                                                                                                                                                              
[12778] "Cardiopulmonary"                                                                                                                                                      
[12779] "Colorectal"                                                                                                                                                           
[12780] "Autocrine_Systems"                                                                                                                                                    
[12781] "Spindle_Pole_Body"                                                                                                                                                    
[12782] "Coated_Pit"                                                                                                                                                           
[12783] "Homeo_Domain"                                                                                                                                                         
[12784] "Keratin_Filament"                                                                                                                                                     
[12785] "Alpha_Helix"                                                                                                                                                          
[12786] "Cis-Acting_Sequence"                                                                                                                                                  
[12787] "_5_Untranslated_Region"                                                                                                                                               
[12788] "Response_Elements"                                                                                                                                                    
[12789] "_3_Untranslated_Region"                                                                                                                                               
[12790] "Intracisternal_A-Particle"                                                                                                                                            
[12791] "Chromosome_Fragile_Site"                                                                                                                                              
[12792] "Cell_Surface_Structure"                                                                                                                                               
[12793] "Chromosome_Structure"                                                                                                                                                 
[12794] "Fundus"                                                                                                                                                               
[12795] "Protein_Domain"                                                                                                                                                       
[12796] "_5q"                                                                                                                                                                  
[12797] "_8p"                                                                                                                                                                  
[12798] "_17p"                                                                                                                                                                 
[12799] "_18q"                                                                                                                                                                 
[12800] "_7q"                                                                                                                                                                  
[12801] "_5q31"                                                                                                                                                                
[12802] "_7q31"                                                                                                                                                                
[12803] "_17p12"                                                                                                                                                               
[12804] "_8p22"                                                                                                                                                                
[12805] "_11q"                                                                                                                                                                 
[12806] "_11q23"                                                                                                                                                               
[12807] "BAT_Locus"                                                                                                                                                            
[12808] "_3p"                                                                                                                                                                  
[12809] "Lobe"                                                                                                                                                                 
[12810] "Myelogenous"                                                                                                                                                          
[12811] "t_8_21_q22_q22"                                                                                                                                                       
[12812] "Allogeneic_Lymphocyte"                                                                                                                                                
[12813] "B-DNA"                                                                                                                                                                
[12814] "Embryonic_Fluid"                                                                                                                                                      
[12815] "All_Sites"                                                                                                                                                            
[12816] "Anatomic_Sites_Other"                                                                                                                                                 
[12817] "Breast_Fluid_or_Secretion"                                                                                                                                            
[12818] "Chromatin_Structure"                                                                                                                                                  
[12819] "Contractile_System"                                                                                                                                                   
[12820] "DNA_Structure"                                                                                                                                                        
[12821] "Drug_Binding_Site"                                                                                                                                                    
[12822] "MYC_Box"                                                                                                                                                              
[12823] "Peptide_Conformation"                                                                                                                                                 
[12824] "Putative_DNA_Chromatin_Binding_Motif_1"                                                                                                                               
[12825] "Skin_Fluid_or_Secretion"                                                                                                                                              
[12826] "Transmembrane_Domain"                                                                                                                                                 
[12827] "Unspecified_Anatomic_Sites"                                                                                                                                           
[12828] "V3_Loop"                                                                                                                                                              
[12829] "Whole_Organism"                                                                                                                                                       
[12830] "intravesical"                                                                                                                                                         
[12831] "Adrenal_Fluid_or_Secretion"                                                                                                                                           
[12832] "Connective_Tissue_Fluid_or_Secretion"                                                                                                                                 
[12833] "Head_and_Neck_Fluids_and_Secretions"                                                                                                                                  
[12834] "Multiple_Cancer_Sites"                                                                                                                                                
[12835] "Multiple_Anatomic_Sites"                                                                                                                                              
[12836] "Histone_Fold"                                                                                                                                                         
[12837] "HMG_Domain"                                                                                                                                                           
[12838] "POU_Domain"                                                                                                                                                           
[12839] "Winged_Helix"                                                                                                                                                         
[12840] "DNA_Binding_Domain"                                                                                                                                                   
[12841] "Protein_Binding_Domain"                                                                                                                                               
[12842] "Zinc-Binding_DNA-Binding_Motif"                                                                                                                                       
[12843] "Hormone_Receptor_DNA-Binding_Domain"                                                                                                                                  
[12844] "Zinc_Cluster"                                                                                                                                                         
[12845] "Mitotic_Chromosome"                                                                                                                                                   
[12846] "Interphase_Chromosome"                                                                                                                                                
[12847] "Chromosome_Band"                                                                                                                                                      
[12848] "Chromatin_Fiber"                                                                                                                                                      
[12849] "Higher_Order_Chromatin_Structure"                                                                                                                                     
[12850] "Chromatin_Loop"                                                                                                                                                       
[12851] "Chromosome_Territory"                                                                                                                                                 
[12852] "Matrix_Attachment_Region"                                                                                                                                             
[12853] "Death_Domain"                                                                                                                                                         
[12854] "TRAF_Domain"                                                                                                                                                          
[12855] "Breast_and_Ovary"                                                                                                                                                     
[12856] "Short_Tandem_Repeat"                                                                                                                                                  
[12857] "Anatomy_Modifier"                                                                                                                                                     
[12858] "Immunoglobulin_Diversity_Region"                                                                                                                                      
[12859] "Bone_and_Cartilage_Funding"                                                                                                                                           
[12860] "Gene_Structure"                                                                                                                                                       
[12861] "Nuclear_Structure"                                                                                                                                                    
[12862] "Nonexchangeable_Site"                                                                                                                                                 
[12863] "Microtubule_Bundle"                                                                                                                                                   
[12864] "RNA_Conformation"                                                                                                                                                     
[12865] "bHLH_Domain"                                                                                                                                                          
[12866] "Pre-Condensed_Chromosomes"                                                                                                                                            
[12867] "Other_Body_Fluids_and_Secretions"                                                                                                                                     
[12868] "Metal_Binding_Site"                                                                                                                                                   
[12869] "Linear_Sequence_Epitopes"                                                                                                                                             
[12870] "Sister_Chromatid"                                                                                                                                                     
[12871] "Bone_Marrow_Stem_Cell"                                                                                                                                                
[12872] "Cytoplasmic_Tail"                                                                                                                                                     
[12873] "Extracellular_Domain"                                                                                                                                                 
[12874] "Protease_Domain"                                                                                                                                                      
[12875] "Proximal_Enhancer_Elements"                                                                                                                                           
[12876] "Distal_Enhancer_Elements"                                                                                                                                             
[12877] "Upstream_Enhancer"                                                                                                                                                    
[12878] "Downstream_Enhancer"                                                                                                                                                  
[12879] "Vaginal_and_Other_Genital"                                                                                                                                            
[12880] "Bronchial_Secretion"                                                                                                                                                  
[12881] "_20q13"                                                                                                                                                               
[12882] "_9q34_1"                                                                                                                                                              
[12883] "_1q24-q25"                                                                                                                                                            
[12884] "_14q32_3"                                                                                                                                                             
[12885] "Xp11_2-p11_4"                                                                                                                                                         
[12886] "_3p21_3"                                                                                                                                                              
[12887] "_2pter-p12"                                                                                                                                                           
[12888] "_1p21-p13"                                                                                                                                                            
[12889] "_19q13_1"                                                                                                                                                             
[12890] "_18q21_3"                                                                                                                                                             
[12891] "_19q13_1-q13_2"                                                                                                                                                       
[12892] "_22q11"                                                                                                                                                               
[12893] "_1p32"                                                                                                                                                                
[12894] "_10p13"                                                                                                                                                               
[12895] "_7q34"                                                                                                                                                                
[12896] "_17q21"                                                                                                                                                               
[12897] "_13q12_3"                                                                                                                                                             
[12898] "_11q23_3"                                                                                                                                                             
[12899] "_11q13"                                                                                                                                                               
[12900] "_16q22_1"                                                                                                                                                             
[12901] "_12q14"                                                                                                                                                               
[12902] "_6p21_2"                                                                                                                                                              
[12903] "_11p15_5"                                                                                                                                                             
[12904] "_9p21"                                                                                                                                                                
[12905] "_14q24_3-q31"                                                                                                                                                         
[12906] "_10p11_2"                                                                                                                                                             
[12907] "_17p13_3"                                                                                                                                                             
[12908] "_5q33-q35"                                                                                                                                                            
[12909] "_10q11-q12"                                                                                                                                                           
[12910] "_20q11_2"                                                                                                                                                             
[12911] "_7p12"                                                                                                                                                                
[12912] "_8q22-q23"                                                                                                                                                            
[12913] "Xp11_2"                                                                                                                                                               
[12914] "_12q23"                                                                                                                                                               
[12915] "_12p12"                                                                                                                                                               
[12916] "_7q32-q36"                                                                                                                                                            
[12917] "_3p11_2"                                                                                                                                                              
[12918] "_19p13_1"                                                                                                                                                             
[12919] "_17q21_1"                                                                                                                                                             
[12920] "_12q13"                                                                                                                                                               
[12921] "_2q33_3-q34"                                                                                                                                                          
[12922] "_21q22_3"                                                                                                                                                             
[12923] "_1q21-q23"                                                                                                                                                            
[12924] "_12p13"                                                                                                                                                               
[12925] "_3q24-q28"                                                                                                                                                            
[12926] "_22q12"                                                                                                                                                               
[12927] "_4q34-q35"                                                                                                                                                            
[12928] "_15q26_1"                                                                                                                                                             
[12929] "_11q13_3"                                                                                                                                                             
[12930] "_1p36_2-p36_1"                                                                                                                                                        
[12931] "_14q13"                                                                                                                                                               
[12932] "_11q24_1-q24_3"                                                                                                                                                       
[12933] "_13q12"                                                                                                                                                               
[12934] "_14q24_3"                                                                                                                                                             
[12935] "_2p23-p22"                                                                                                                                                            
[12936] "_6q21"                                                                                                                                                                
[12937] "_12q13_2-q13_3"                                                                                                                                                       
[12938] "_2q14"                                                                                                                                                                
[12939] "_7p13"                                                                                                                                                                
[12940] "_4q21"                                                                                                                                                                
[12941] "_1p"                                                                                                                                                                  
[12942] "_1p36_3"                                                                                                                                                              
[12943] "_1q"                                                                                                                                                                  
[12944] "_11p"                                                                                                                                                                 
[12945] "_10p"                                                                                                                                                                 
[12946] "_10q"                                                                                                                                                                 
[12947] "_12p"                                                                                                                                                                 
[12948] "_12q"                                                                                                                                                                 
[12949] "_13q"                                                                                                                                                                 
[12950] "_13p"                                                                                                                                                                 
[12951] "_20q11-q12"                                                                                                                                                           
[12952] "_14p"                                                                                                                                                                 
[12953] "_14q"                                                                                                                                                                 
[12954] "_15q"                                                                                                                                                                 
[12955] "_15p"                                                                                                                                                                 
[12956] "_16p"                                                                                                                                                                 
[12957] "_16q"                                                                                                                                                                 
[12958] "_17q"                                                                                                                                                                 
[12959] "_18p"                                                                                                                                                                 
[12960] "_19p"                                                                                                                                                                 
[12961] "_19q"                                                                                                                                                                 
[12962] "_2p"                                                                                                                                                                  
[12963] "_2q"                                                                                                                                                                  
[12964] "_20q"                                                                                                                                                                 
[12965] "_20p"                                                                                                                                                                 
[12966] "_21p"                                                                                                                                                                 
[12967] "_21q"                                                                                                                                                                 
[12968] "_22q"                                                                                                                                                                 
[12969] "_22p"                                                                                                                                                                 
[12970] "_3q"                                                                                                                                                                  
[12971] "_4q"                                                                                                                                                                  
[12972] "_4p"                                                                                                                                                                  
[12973] "_5p"                                                                                                                                                                  
[12974] "_6p"                                                                                                                                                                  
[12975] "_6q"                                                                                                                                                                  
[12976] "_7p"                                                                                                                                                                  
[12977] "_8q"                                                                                                                                                                  
[12978] "_9p"                                                                                                                                                                  
[12979] "_9q"                                                                                                                                                                  
[12980] "Xp"                                                                                                                                                                   
[12981] "Xq"                                                                                                                                                                   
[12982] "_6p25-p23"                                                                                                                                                            
[12983] "_1p32-p31"                                                                                                                                                            
[12984] "_19p13_2"                                                                                                                                                             
[12985] "_11p11_2"                                                                                                                                                             
[12986] "_4q11-q12"                                                                                                                                                            
[12987] "_12p12_1"                                                                                                                                                             
[12988] "_1p35-p34_3"                                                                                                                                                          
[12989] "_8q13"                                                                                                                                                                
[12990] "_1p32-p31_or_1p31-q12"                                                                                                                                                
[12991] "_18q21_1"                                                                                                                                                             
[12992] "_16q22-q23"                                                                                                                                                           
[12993] "_17q25"                                                                                                                                                               
[12994] "_6q24-q27"                                                                                                                                                            
[12995] "_14q23"                                                                                                                                                               
[12996] "_5q21-q22"                                                                                                                                                            
[12997] "Xq26_3-q27_1"                                                                                                                                                         
[12998] "_12q13-q14"                                                                                                                                                           
[12999] "_19p13_1-p13_2"                                                                                                                                                       
[13000] "_8q11"                                                                                                                                                                
[13001] "_1p34"                                                                                                                                                                
[13002] "_2p16"                                                                                                                                                                
[13003] "_6q22-q23"                                                                                                                                                            
[13004] "_8q22"                                                                                                                                                                
[13005] "_20q13_1"                                                                                                                                                             
[13006] "_8q24"                                                                                                                                                                
[13007] "_1p34_3"                                                                                                                                                              
[13008] "_2p24_1"                                                                                                                                                              
[13009] "_1p36_3-p36_2"                                                                                                                                                        
[13010] "_22q12_2"                                                                                                                                                             
[13011] "_10q24"                                                                                                                                                               
[13012] "_3p23-p21"                                                                                                                                                            
[13013] "_8q24_1"                                                                                                                                                              
[13014] "_1p13"                                                                                                                                                                
[13015] "_1q23-q31"                                                                                                                                                            
[13016] "_15q25-q26"                                                                                                                                                           
[13017] "_22q12_3-q13_1"                                                                                                                                                       
[13018] "_6p21"                                                                                                                                                                
[13019] "_9q31"                                                                                                                                                                
[13020] "_3p25"                                                                                                                                                                
[13021] "_7p22-p15"                                                                                                                                                            
[13022] "_2cen-q13"                                                                                                                                                            
[13023] "_13q14_2"                                                                                                                                                             
[13024] "_2p13-p12"                                                                                                                                                            
[13025] "_10q11_2"                                                                                                                                                             
[13026] "_6q21-q22"                                                                                                                                                            
[13027] "_1q22-q24"                                                                                                                                                            
[13028] "_22q11_2"                                                                                                                                                             
[13029] "_11p12-p11_22"                                                                                                                                                        
[13030] "_20q11_2_or_20q11_2-q13"                                                                                                                                              
[13031] "_11p15"                                                                                                                                                               
[13032] "_6p21_1-p21_3"                                                                                                                                                        
[13033] "_19q13"                                                                                                                                                               
[13034] "_17q11_2"                                                                                                                                                             
[13035] "_3p22"                                                                                                                                                                
[13036] "_3q27"                                                                                                                                                                
[13037] "_17q11_2-q12"                                                                                                                                                         
[13038] "_3p24_1-p22"                                                                                                                                                          
[13039] "_21q22_1"                                                                                                                                                             
[13040] "_7q33-q35"                                                                                                                                                            
[13041] "_3q21-q25"                                                                                                                                                            
[13042] "_6p21_3"                                                                                                                                                              
[13043] "_17p13_1"                                                                                                                                                             
[13044] "_1q42_1"                                                                                                                                                              
[13045] "_1p36"                                                                                                                                                                
[13046] "_3p21-p14"                                                                                                                                                            
[13047] "_11p13"                                                                                                                                                               
[13048] "_18p11_31-p11_21"                                                                                                                                                     
[13049] "Retinoic_Acid_Response_Element"                                                                                                                                       
[13050] "bHLH-Zip_Domain"                                                                                                                                                      
[13051] "HD-ZIP_Domain"                                                                                                                                                        
[13052] "HT-Zip_Domain"                                                                                                                                                        
[13053] "_15q21-q22"                                                                                                                                                           
[13054] "Poly-A_Addition_Site"                                                                                                                                                 
[13055] "_5q21"                                                                                                                                                                
[13056] "_10q24_3-10qter"                                                                                                                                                      
[13057] "_15q23-15q24"                                                                                                                                                         
[13058] "_16q22_2"                                                                                                                                                             
[13059] "_2p23"                                                                                                                                                                
[13060] "_9q34"                                                                                                                                                                
[13061] "_16p13_3"                                                                                                                                                             
[13062] "_2p22-p21"                                                                                                                                                            
[13063] "_2q32"                                                                                                                                                                
[13064] "_7p22"                                                                                                                                                                
[13065] "_10q23_31"                                                                                                                                                            
[13066] "_19p13"                                                                                                                                                               
[13067] "_1p13_3"                                                                                                                                                              
[13068] "_6q14_3-16_1"                                                                                                                                                         
[13069] "_12q12-12q14"                                                                                                                                                         
[13070] "_19q13_2"                                                                                                                                                             
[13071] "_14q12"                                                                                                                                                               
[13072] "Nucleosomal_Repeat_Length"                                                                                                                                            
[13073] "_3p14_2"                                                                                                                                                              
[13074] "_16p13_1"                                                                                                                                                             
[13075] "Translocation_Breakpoint"                                                                                                                                             
[13076] "Cyclic_AMP_Response_Element"                                                                                                                                          
[13077] "Androgen_Response_Element"                                                                                                                                            
[13078] "SANT_Domain"                                                                                                                                                          
[13079] "_10q11"                                                                                                                                                               
[13080] "_17q23-q24"                                                                                                                                                           
[13081] "_3q25_1-q26_1"                                                                                                                                                        
[13082] "_4q31_1-q31_2"                                                                                                                                                        
[13083] "_7q35-q36"                                                                                                                                                            
[13084] "_9p22_3"                                                                                                                                                              
[13085] "Xq26_1"                                                                                                                                                               
[13086] "Ligand_Binding_Domain"                                                                                                                                                
[13087] "LIM_Domain"                                                                                                                                                           
[13088] "_19p13_3"                                                                                                                                                             
[13089] "_12q14_3-q15"                                                                                                                                                         
[13090] "_9q22_3"                                                                                                                                                              
[13091] "_8q24_12-q24_13"                                                                                                                                                      
[13092] "_6p24"                                                                                                                                                                
[13093] "_7p12_3-p12_1"                                                                                                                                                        
[13094] "_4q25-q27"                                                                                                                                                            
[13095] "_15q15-q21_1"                                                                                                                                                         
[13096] "_8p11_2-p11_1"                                                                                                                                                        
[13097] "_10q26"                                                                                                                                                               
[13098] "_19p13_1-p12"                                                                                                                                                         
[13099] "_16q22"                                                                                                                                                               
[13100] "_4q12-q13"                                                                                                                                                            
[13101] "_3q26_3-q27"                                                                                                                                                          
[13102] "_12q12-q13"                                                                                                                                                           
[13103] "_22q11_21"                                                                                                                                                            
[13104] "_8q13-qter"                                                                                                                                                           
[13105] "_6q22"                                                                                                                                                                
[13106] "_13q12-q13"                                                                                                                                                           
[13107] "_8q24_11-q24_13"                                                                                                                                                      
[13108] "_11p12-p11"                                                                                                                                                           
[13109] "_1p36_13-p36_11"                                                                                                                                                      
[13110] "_17q21_3"                                                                                                                                                             
[13111] "_13q14_1-q14_2"                                                                                                                                                       
[13112] "_18p11_3"                                                                                                                                                             
[13113] "_20q12-q13"                                                                                                                                                           
[13114] "_10q21"                                                                                                                                                               
[13115] "_7q21_1"                                                                                                                                                              
[13116] "_19q13_3-q13_4"                                                                                                                                                       
[13117] "_8p23_1-p21_3"                                                                                                                                                        
[13118] "_5q33_2-q33_3"                                                                                                                                                        
[13119] "_1q21-q22"                                                                                                                                                            
[13120] "_3p24_3"                                                                                                                                                              
[13121] "_12p12_3"                                                                                                                                                             
[13122] "_3q26"                                                                                                                                                                
[13123] "_3p21"                                                                                                                                                                
[13124] "_4q25"                                                                                                                                                                
[13125] "_3p26-p25"                                                                                                                                                            
[13126] "_15q22-q24"                                                                                                                                                           
[13127] "_2q31-q33"                                                                                                                                                            
[13128] "Male_Genital_System_Fluid_or_Secretion"                                                                                                                               
[13129] "_5q35_1"                                                                                                                                                              
[13130] "Internal_Ribosome_Entry_Site"                                                                                                                                         
[13131] "Anatomic_Sites"                                                                                                                                                       
[13132] "Hypoxia-Responsive_Elements"                                                                                                                                          
[13133] "ETS_Domain"                                                                                                                                                           
[13134] "RNA_Recognition_Motif"                                                                                                                                                
[13135] "bZIP_Domain"                                                                                                                                                          
[13136] "Respiratory_System_Fluid_or_Secretion"                                                                                                                                
[13137] "Repair_Complex"                                                                                                                                                       
[13138] "Central_DNA_Flap_Sequence"                                                                                                                                            
[13139] "G-Quartets"                                                                                                                                                           
[13140] "_1p32-q12"                                                                                                                                                            
[13141] "t_12_21_p13_q22"                                                                                                                                                      
[13142] "_15q23-q25"                                                                                                                                                           
[13143] "_21q22_2"                                                                                                                                                             
[13144] "_4q13-q21"                                                                                                                                                            
[13145] "Intraventricular"                                                                                                                                                     
[13146] "Bromodomain"                                                                                                                                                          
[13147] "_5p15_33"                                                                                                                                                             
[13148] "Regulatory_Element"                                                                                                                                                   
[13149] "Plasma_Membrane"                                                                                                                                                      
[13150] "Zonula_Adherens"                                                                                                                                                      
[13151] "_20S_Proteasome"                                                                                                                                                      
[13152] "Conformation"                                                                                                                                                         
[13153] "Blastocyst"                                                                                                                                                           
[13154] "Inner_Cell_Mass"                                                                                                                                                      
[13155] "AT_Hook_Motif"                                                                                                                                                        
[13156] "Minor_Groove"                                                                                                                                                         
[13157] "Major_Groove"                                                                                                                                                         
[13158] "HMG-Box"                                                                                                                                                              
[13159] "Nucleosome_Binding_Domain"                                                                                                                                            
[13160] "Ring_Finger_Domain"                                                                                                                                                   
[13161] "_14q11"                                                                                                                                                               
[13162] "_3p21_3-p21_2"                                                                                                                                                        
[13163] "Xq28"                                                                                                                                                                 
[13164] "_5q11-q12"                                                                                                                                                            
[13165] "_13q22-q34"                                                                                                                                                           
[13166] "_5q13-q14"                                                                                                                                                            
[13167] "_7q36_1"                                                                                                                                                              
[13168] "_11q22-q23"                                                                                                                                                           
[13169] "Xq25"                                                                                                                                                                 
[13170] "_20q13_3"                                                                                                                                                             
[13171] "_22q11-q13"                                                                                                                                                           
[13172] "_3p26_2"                                                                                                                                                              
[13173] "_1q42-q43"                                                                                                                                                            
[13174] "_5q12_2-q13_3"                                                                                                                                                        
[13175] "_3q22_1"                                                                                                                                                              
[13176] "_19p13_3-p13_2"                                                                                                                                                       
[13177] "_2q35"                                                                                                                                                                
[13178] "_3q21"                                                                                                                                                                
[13179] "_8q11_2"                                                                                                                                                              
[13180] "_22q13_1"                                                                                                                                                             
[13181] "_2q21"                                                                                                                                                                
[13182] "_6p12"                                                                                                                                                                
[13183] "_7q21_3-q22_1"                                                                                                                                                        
[13184] "_2q33"                                                                                                                                                                
[13185] "_7q21_3"                                                                                                                                                              
[13186] "_2q22-q23"                                                                                                                                                            
[13187] "_7q22_1"                                                                                                                                                              
[13188] "_8p12-p11_2"                                                                                                                                                          
[13189] "_5q23-q31"                                                                                                                                                            
[13190] "_1q41"                                                                                                                                                                
[13191] "_6p21_1"                                                                                                                                                              
[13192] "_7p12-p11_2"                                                                                                                                                          
[13193] "Xq13_1"                                                                                                                                                               
[13194] "_6q27"                                                                                                                                                                
[13195] "_3q21-q28"                                                                                                                                                            
[13196] "_14q11_2"                                                                                                                                                             
[13197] "_3q13_31"                                                                                                                                                             
[13198] "_8q24_12"                                                                                                                                                             
[13199] "_1p22"                                                                                                                                                                
[13200] "_16q24_3"                                                                                                                                                             
[13201] "_8q12-q13"                                                                                                                                                            
[13202] "Xq11-q13"                                                                                                                                                             
[13203] "_10p15_1"                                                                                                                                                             
[13204] "_20q13_33"                                                                                                                                                            
[13205] "_10q24-q25_2"                                                                                                                                                         
[13206] "Xq22_1"                                                                                                                                                               
[13207] "_5q11_2-q13_1"                                                                                                                                                        
[13208] "_11p15_3"                                                                                                                                                             
[13209] "_6p21_31"                                                                                                                                                             
[13210] "_1p35_2"                                                                                                                                                              
[13211] "_1p13_1"                                                                                                                                                              
[13212] "_6q22_1-q22_3"                                                                                                                                                        
[13213] "_11q22_3"                                                                                                                                                             
[13214] "_12q15"                                                                                                                                                               
[13215] "_1p22_1"                                                                                                                                                              
[13216] "Beta_Sheet"                                                                                                                                                           
[13217] "Long_Interspersed_Element"                                                                                                                                            
[13218] "Short_Interspersed_Element"                                                                                                                                           
[13219] "Erythroid"                                                                                                                                                            
[13220] "Immunoglobulin_Domain"                                                                                                                                                
[13221] "Intraepithelial"                                                                                                                                                      
[13222] "Intrahepatic"                                                                                                                                                         
[13223] "Nuclear_Lamina"                                                                                                                                                       
[13224] "Lymphoid"                                                                                                                                                             
[13225] "Nucleosome_Core_Particle"                                                                                                                                             
[13226] "Scaffold-Associated_Region"                                                                                                                                           
[13227] "_3q21-q24"                                                                                                                                                            
[13228] "_1p22-p21"                                                                                                                                                            
[13229] "_8p21-p12"                                                                                                                                                            
[13230] "_13q14"                                                                                                                                                               
[13231] "_11p15_1-p14"                                                                                                                                                         
[13232] "_14q24_1"                                                                                                                                                             
[13233] "Somatosensory_Receptor"                                                                                                                                               
[13234] "_2q33_1"                                                                                                                                                              
[13235] "Mechanoreceptor"                                                                                                                                                      
[13236] "Thermoreceptor"                                                                                                                                                       
[13237] "Proprioceptor"                                                                                                                                                        
[13238] "Muscle_Spindle"                                                                                                                                                       
[13239] "_16p12"                                                                                                                                                               
[13240] "Golgi_Tendon_Organ"                                                                                                                                                   
[13241] "_2p23_3"                                                                                                                                                              
[13242] "_9q34_3"                                                                                                                                                              
[13243] "_5q13"                                                                                                                                                                
[13244] "_8p11_23"                                                                                                                                                             
[13245] "_5p13_3"                                                                                                                                                              
[13246] "_9p22_2"                                                                                                                                                              
[13247] "_17q12"                                                                                                                                                               
[13248] "_17q12-q21_1"                                                                                                                                                         
[13249] "_6q22_33-q24_1"                                                                                                                                                       
[13250] "_11q14"                                                                                                                                                               
[13251] "_19p13_12"                                                                                                                                                            
[13252] "_5q33_2"                                                                                                                                                              
[13253] "_11q24"                                                                                                                                                               
[13254] "_8p22-p11"                                                                                                                                                            
[13255] "_8q13_1"                                                                                                                                                              
[13256] "_4q12"                                                                                                                                                                
[13257] "_20q12"                                                                                                                                                               
[13258] "_20q12-q13_12"                                                                                                                                                        
[13259] "_20q11_1"                                                                                                                                                             
[13260] "_21q11_2"                                                                                                                                                             
[13261] "_1p36_1"                                                                                                                                                              
[13262] "_12q13_1"                                                                                                                                                             
[13263] "_7p14-p13"                                                                                                                                                            
[13264] "_2q34-q35"                                                                                                                                                            
[13265] "_6p25"                                                                                                                                                                
[13266] "_16q24_2-q24_3"                                                                                                                                                       
[13267] "_1p33-p31"                                                                                                                                                            
[13268] "_5q35_1-qter"                                                                                                                                                         
[13269] "_11p15_2-p14_3"                                                                                                                                                       
[13270] "_1p31"                                                                                                                                                                
[13271] "_17q24"                                                                                                                                                               
[13272] "_16q23_1"                                                                                                                                                             
[13273] "_20q13_2"                                                                                                                                                             
[13274] "_1p21-p13_3"                                                                                                                                                          
[13275] "_7q11_1"                                                                                                                                                              
[13276] "_17q23"                                                                                                                                                               
[13277] "_20q13_13"                                                                                                                                                            
[13278] "_2p16_3"                                                                                                                                                              
[13279] "_10q22-q23"                                                                                                                                                           
[13280] "_14q31_1"                                                                                                                                                             
[13281] "_15q21_2"                                                                                                                                                             
[13282] "_13q21"                                                                                                                                                               
[13283] "_10q11-p12"                                                                                                                                                           
[13284] "_11q13_1-q13_2"                                                                                                                                                       
[13285] "_8p22-p21_3"                                                                                                                                                          
[13286] "_13q13_3"                                                                                                                                                             
[13287] "_5q13_1"                                                                                                                                                              
[13288] "_5q12-q13"                                                                                                                                                            
[13289] "Xp11_21-p11_22"                                                                                                                                                       
[13290] "_11q13_1"                                                                                                                                                             
[13291] "_17p13_2"                                                                                                                                                             
[13292] "_22q13_2-q13_31"                                                                                                                                                      
[13293] "_1p31-p22"                                                                                                                                                            
[13294] "_2p21"                                                                                                                                                                
[13295] "_1q32"                                                                                                                                                                
[13296] "_17q11-q21_3"                                                                                                                                                         
[13297] "_15q22_2"                                                                                                                                                             
[13298] "_20pter-q12"                                                                                                                                                          
[13299] "_1q42_1-q43"                                                                                                                                                          
[13300] "_22q11_23"                                                                                                                                                            
[13301] "_1p35"                                                                                                                                                                
[13302] "_4q22"                                                                                                                                                                
[13303] "_16q12"                                                                                                                                                               
[13304] "_17q22-q23"                                                                                                                                                           
[13305] "_1q21"                                                                                                                                                                
[13306] "_10q23_2-q23_3"                                                                                                                                                       
[13307] "_8p11"                                                                                                                                                                
[13308] "_11p15_2-p15_1"                                                                                                                                                       
[13309] "_7p21_3"                                                                                                                                                              
[13310] "_12p13_32"                                                                                                                                                            
[13311] "_16p13_12"                                                                                                                                                            
[13312] "_20q12-q13_2"                                                                                                                                                         
[13313] "_1q32_2"                                                                                                                                                              
[13314] "_19p13_2-p12"                                                                                                                                                         
[13315] "_17q11_2-q21_1"                                                                                                                                                       
[13316] "_17q23_1"                                                                                                                                                             
[13317] "_8q24_1-q24_3"                                                                                                                                                        
[13318] "_14q24"                                                                                                                                                               
[13319] "_14q11_2-q12"                                                                                                                                                         
[13320] "BIR_Domain"                                                                                                                                                           
[13321] "UBC_Domain"                                                                                                                                                           
[13322] "_22q13_3"                                                                                                                                                             
[13323] "_2q12_3"                                                                                                                                                              
[13324] "_12q24_21"                                                                                                                                                            
[13325] "Bcl-2_Homology_Domain"                                                                                                                                                
[13326] "BH1_Domain"                                                                                                                                                           
[13327] "BH2_Domain"                                                                                                                                                           
[13328] "BH3_Domain"                                                                                                                                                           
[13329] "BH4_Domain"                                                                                                                                                           
[13330] "_11q22"                                                                                                                                                               
[13331] "_2p11"                                                                                                                                                                
[13332] "_4q28-q31"                                                                                                                                                            
[13333] "_8q21_13"                                                                                                                                                             
[13334] "_2q21-q22"                                                                                                                                                            
[13335] "WAP_Domain"                                                                                                                                                           
[13336] "_3p22-p21_3"                                                                                                                                                          
[13337] "_3q13_1-q13_2"                                                                                                                                                        
[13338] "_11pter-p13"                                                                                                                                                          
[13339] "_11q23_1"                                                                                                                                                             
[13340] "_17q23-q25"                                                                                                                                                           
[13341] "Non-Neural_Epithelial_Tissues"                                                                                                                                        
[13342] "Cadherin_Domain"                                                                                                                                                      
[13343] "_16p11_2"                                                                                                                                                             
[13344] "_9q33"                                                                                                                                                                
[13345] "_12q22"                                                                                                                                                               
[13346] "_9q32"                                                                                                                                                                
[13347] "Xq26"                                                                                                                                                                 
[13348] "_1q23"                                                                                                                                                                
[13349] "_1q25"                                                                                                                                                                
[13350] "EGF-Like_Domain"                                                                                                                                                      
[13351] "Disintegrin_Domain"                                                                                                                                                   
[13352] "_17q11-q12"                                                                                                                                                           
[13353] "_9p11_2"                                                                                                                                                              
[13354] "_14q32"                                                                                                                                                               
[13355] "_17p13-p12"                                                                                                                                                           
[13356] "_7q31_1"                                                                                                                                                              
[13357] "_8q21"                                                                                                                                                                
[13358] "FHA_Domain"                                                                                                                                                           
[13359] "Breast_Cancer_Carboxy-Terminal_Domain"                                                                                                                                
[13360] "_1p36_11"                                                                                                                                                             
[13361] "_12p11_1"                                                                                                                                                             
[13362] "_4q32_2"                                                                                                                                                              
[13363] "Nucleoplasm"                                                                                                                                                          
[13364] "Nuclear_Pore_Complex"                                                                                                                                                 
[13365] "_5q35"                                                                                                                                                                
[13366] "_20pter-p12"                                                                                                                                                          
[13367] "_2q35-q36"                                                                                                                                                            
[13368] "Desmosome"                                                                                                                                                            
[13369] "EF-Hand_Domain"                                                                                                                                                       
[13370] "_1q43-q44"                                                                                                                                                            
[13371] "_3q26_3"                                                                                                                                                              
[13372] "_4q13_3-q21_1"                                                                                                                                                        
[13373] "SAM_Domain"                                                                                                                                                           
[13374] "_15q22_1-q22_33"                                                                                                                                                      
[13375] "_6p24_3"                                                                                                                                                              
[13376] "_16p12-p11_2"                                                                                                                                                         
[13377] "_10q21_1"                                                                                                                                                             
[13378] "Trefoil_Motif"                                                                                                                                                        
[13379] "_18p11_32"                                                                                                                                                            
[13380] "Coiled-Coil_Domain"                                                                                                                                                   
[13381] "_8p23_1"                                                                                                                                                              
[13382] "_9p23"                                                                                                                                                                
[13383] "_26S_ATP-Dependent_Proteasome"                                                                                                                                        
[13384] "_8q21-q24"                                                                                                                                                            
[13385] "_2p14-p13"                                                                                                                                                            
[13386] "_1q32-q41"                                                                                                                                                            
[13387] "TRIM_Motif"                                                                                                                                                           
[13388] "RSXpSXP_Motif"                                                                                                                                                        
[13389] "RXY_FXpSXP_Motif"                                                                                                                                                     
[13390] "Phosphoserine_Motif"                                                                                                                                                  
[13391] "_14q21-q22"                                                                                                                                                           
[13392] "_1q22-q25"                                                                                                                                                            
[13393] "_1q23-q25"                                                                                                                                                            
[13394] "_17q11"                                                                                                                                                               
[13395] "_12q11-q14"                                                                                                                                                           
[13396] "Cell_Junction"                                                                                                                                                        
[13397] "Anchoring_Junction"                                                                                                                                                   
[13398] "Fascia_Adherens"                                                                                                                                                      
[13399] "_10q24-q26"                                                                                                                                                           
[13400] "_2p13-q13"                                                                                                                                                            
[13401] "_5q31_1"                                                                                                                                                              
[13402] "_13q14_3"                                                                                                                                                             
[13403] "_10q22_1-q23"                                                                                                                                                         
[13404] "_5q32-q34"                                                                                                                                                            
[13405] "_2q33-q36"                                                                                                                                                            
[13406] "_1p35-p31_3"                                                                                                                                                          
[13407] "_12q22-q23"                                                                                                                                                           
[13408] "_9q22_32"                                                                                                                                                             
[13409] "_7q22"                                                                                                                                                                
[13410] "_7q21-q22"                                                                                                                                                            
[13411] "_6q24-q25"                                                                                                                                                            
[13412] "_15q24-q25"                                                                                                                                                           
[13413] "_15q21_1-q21_2"                                                                                                                                                       
[13414] "_1p35_1-p36_23"                                                                                                                                                       
[13415] "_8q22_3-q23"                                                                                                                                                          
[13416] "_4q26-q32"                                                                                                                                                            
[13417] "_3p21_1"                                                                                                                                                              
[13418] "_2p12"                                                                                                                                                                
[13419] "_4p13"                                                                                                                                                                
[13420] "_2p13_1"                                                                                                                                                              
[13421] "_20p12"                                                                                                                                                               
[13422] "_4p14-q21"                                                                                                                                                            
[13423] "_6p11_1"                                                                                                                                                              
[13424] "_6p24-p23"                                                                                                                                                            
[13425] "_1p35-p32"                                                                                                                                                            
[13426] "_12pter-p12"                                                                                                                                                          
[13427] "_3q13_3-q21"                                                                                                                                                          
[13428] "_10q22_3"                                                                                                                                                             
[13429] "_2q33-q34"                                                                                                                                                            
[13430] "Xp22_2"                                                                                                                                                               
[13431] "_8p21"                                                                                                                                                                
[13432] "_21q21_2"                                                                                                                                                             
[13433] "_3p14_3-p14_2"                                                                                                                                                        
[13434] "_4q13_1"                                                                                                                                                              
[13435] "_22q12_1"                                                                                                                                                             
[13436] "Xq22-q23"                                                                                                                                                             
[13437] "_1q22"                                                                                                                                                                
[13438] "_13p12"                                                                                                                                                               
[13439] "_8q24_3"                                                                                                                                                              
[13440] "_4p16"                                                                                                                                                                
[13441] "_19q12"                                                                                                                                                               
[13442] "_15q15_2"                                                                                                                                                             
[13443] "_20q13_2-q13_3"                                                                                                                                                       
[13444] "_4q34_1-q34_3"                                                                                                                                                        
[13445] "_6q26-q27"                                                                                                                                                            
[13446] "_4p16_3"                                                                                                                                                              
[13447] "_20q12-q13_1"                                                                                                                                                         
[13448] "Xp11_22"                                                                                                                                                              
[13449] "_11q13_5"                                                                                                                                                             
[13450] "_1q42"                                                                                                                                                                
[13451] "_19p13_11"                                                                                                                                                            
[13452] "_3p21_3-p21_1"                                                                                                                                                        
[13453] "_2p22_3-p21"                                                                                                                                                          
[13454] "_19q13_3"                                                                                                                                                             
[13455] "BRCT_Domain"                                                                                                                                                          
[13456] "Walker-A_Motif"                                                                                                                                                       
[13457] "PWWP_Domain"                                                                                                                                                          
[13458] "_3q13"                                                                                                                                                                
[13459] "_5p15_1-p14"                                                                                                                                                          
[13460] "Immunoreceptor_Tyrosine-Based_Motif"                                                                                                                                  
[13461] "ITAM"                                                                                                                                                                 
[13462] "ITIM"                                                                                                                                                                 
[13463] "Post-Translational_Modification_Site"                                                                                                                                 
[13464] "N-Glycosylation_Site"                                                                                                                                                 
[13465] "Myristic_Acylation_Site"                                                                                                                                              
[13466] "Palmitic_Acylation_Site"                                                                                                                                              
[13467] "Phosphorylation_Site"                                                                                                                                                 
[13468] "YDYVHL_Motif"                                                                                                                                                         
[13469] "Tyrosine_Phosphorylation_Site"                                                                                                                                        
[13470] "Serine_Phosphorylation_Site"                                                                                                                                          
[13471] "Threonine_Phosphorylation_Site"                                                                                                                                       
[13472] "YXXP_Motif"                                                                                                                                                           
[13473] "PKC_Phosphorylation_Site"                                                                                                                                             
[13474] "Amphipathic_Alpha_Helix"                                                                                                                                              
[13475] "Disulfide_Linkage"                                                                                                                                                    
[13476] "Globular_Region"                                                                                                                                                      
[13477] "Tertiary_Protein_Structure"                                                                                                                                           
[13478] "Protein_Region"                                                                                                                                                       
[13479] "_7q21_2-q22_1"                                                                                                                                                        
[13480] "_14q31"                                                                                                                                                               
[13481] "Acidic_Region"                                                                                                                                                        
[13482] "Cysteine-Rich_Domain"                                                                                                                                                 
[13483] "Cellular_Membrane"                                                                                                                                                    
[13484] "NAD-Binding_Domain"                                                                                                                                                   
[13485] "GXGXXXG_Motif"                                                                                                                                                        
[13486] "Substrate_Domain"                                                                                                                                                     
[13487] "ATPase_Domain"                                                                                                                                                        
[13488] "Tyrosine_Kinase_Domain"                                                                                                                                               
[13489] "DH_Domain"                                                                                                                                                            
[13490] "PH_Domain"                                                                                                                                                            
[13491] "RHO_Effector_Domain"                                                                                                                                                  
[13492] "Transcriptional_Activation_Domain"                                                                                                                                    
[13493] "DAG_PE-Binding_Domain"                                                                                                                                                
[13494] "Estrogen_Binding_Domain"                                                                                                                                              
[13495] "GTP_Binding_Domain"                                                                                                                                                   
[13496] "Basolateral_Sorting_Signal"                                                                                                                                           
[13497] "KDEL_Motif"                                                                                                                                                           
[13498] "DIX_Domain"                                                                                                                                                           
[13499] "Mitochondrial_Import_Sequence"                                                                                                                                        
[13500] "Membrane_Localization_Motif"                                                                                                                                          
[13501] "Monobasic_Proteolytic_Cleavage_Site"                                                                                                                                  
[13502] "Nuclear_Localization_Signal"                                                                                                                                          
[13503] "Signal_Peptide"                                                                                                                                                       
[13504] "RNA_Binding_Domain"                                                                                                                                                   
[13505] "KH_Domain"                                                                                                                                                            
[13506] "SET_Domain"                                                                                                                                                           
[13507] "ARID_Domain"                                                                                                                                                          
[13508] "BTB_POZ_Domain"                                                                                                                                                       
[13509] "Zinc_Finger_Domain"                                                                                                                                                   
[13510] "C3H1_Zinc_Finger"                                                                                                                                                     
[13511] "PHD_Finger"                                                                                                                                                           
[13512] "HLH_Motif"                                                                                                                                                            
[13513] "Ankyrin_Repeat"                                                                                                                                                       
[13514] "Armadillo_Repeat"                                                                                                                                                     
[13515] "Beta-Catenin-Binding_Domain"                                                                                                                                          
[13516] "F_Box_Domain"                                                                                                                                                         
[13517] "GSK-Binding_Domain"                                                                                                                                                   
[13518] "PKC_Binding_Site"                                                                                                                                                     
[13519] "Proline-Rich_Domain"                                                                                                                                                  
[13520] "RGS_Domain"                                                                                                                                                           
[13521] "SH2-Binding_Motif"                                                                                                                                                    
[13522] "SH3-Binding_Motif"                                                                                                                                                    
[13523] "PXXP_Motif"                                                                                                                                                           
[13524] "WD_Repeat"                                                                                                                                                            
[13525] "_9q32-q34"                                                                                                                                                            
[13526] "_14q24-q31"                                                                                                                                                           
[13527] "Calcium-Binding_Domain"                                                                                                                                               
[13528] "_3q22_2"                                                                                                                                                              
[13529] "_12p13_2"                                                                                                                                                             
[13530] "EXO_I_Motif"                                                                                                                                                          
[13531] "EXO_II_Motif"                                                                                                                                                         
[13532] "EXO_III_Motif"                                                                                                                                                        
[13533] "_10q24_1"                                                                                                                                                             
[13534] "_8p22-p21"                                                                                                                                                            
[13535] "_10p15-p14"                                                                                                                                                           
[13536] "_5q33_2-qter"                                                                                                                                                         
[13537] "_17q21-q23"                                                                                                                                                           
[13538] "_4q31_23"                                                                                                                                                             
[13539] "_5q32"                                                                                                                                                                
[13540] "_4q11-q13"                                                                                                                                                            
[13541] "Yolk_Sac"                                                                                                                                                             
[13542] "_5q23"                                                                                                                                                                
[13543] "_3q13_12"                                                                                                                                                             
[13544] "UBA_Domain"                                                                                                                                                           
[13545] "_6p22_3"                                                                                                                                                              
[13546] "_11p15_4"                                                                                                                                                             
[13547] "Macromolecular_Structure"                                                                                                                                             
[13548] "Cell_Structure"                                                                                                                                                       
[13549] "Extracellular_Structure"                                                                                                                                              
[13550] "Aggressive"                                                                                                                                                           
[13551] "Immunocompromised"                                                                                                                                                    
[13552] "Acute"                                                                                                                                                                
[13553] "Chronic"                                                                                                                                                              
[13554] "Encapsulated"                                                                                                                                                         
[13555] "Malignant"                                                                                                                                                            
[13556] "Anaplastic"                                                                                                                                                           
[13557] "Indolent"                                                                                                                                                             
[13558] "Localized"                                                                                                                                                            
[13559] "Nonmelanomatous"                                                                                                                                                      
[13560] "Nonmetastatic"                                                                                                                                                        
[13561] "Osteolytic"                                                                                                                                                           
[13562] "Tumor-Derived"                                                                                                                                                        
[13563] "Unresectable"                                                                                                                                                         
[13564] "Hematogenous"                                                                                                                                                         
[13565] "Child"                                                                                                                                                                
[13566] "Alveolar"                                                                                                                                                             
[13567] "Apoptotic"                                                                                                                                                            
[13568] "Borderline"                                                                                                                                                           
[13569] "High_Grade"                                                                                                                                                           
[13570] "Invasive"                                                                                                                                                             
[13571] "In_Situ"                                                                                                                                                              
[13572] "Low_Grade"                                                                                                                                                            
[13573] "Moderately_Differentiated"                                                                                                                                            
[13574] "Mucinous"                                                                                                                                                             
[13575] "Myoepithelial"                                                                                                                                                        
[13576] "Normal"                                                                                                                                                               
[13577] "Papillary"                                                                                                                                                            
[13578] "Poorly_Differentiated"                                                                                                                                                
[13579] "Serous"                                                                                                                                                               
[13580] "Tubular"                                                                                                                                                              
[13581] "Villous"                                                                                                                                                              
[13582] "Well_Differentiated"                                                                                                                                                  
[13583] "Benign"                                                                                                                                                               
[13584] "Recurrent"                                                                                                                                                            
[13585] "Metastatic"                                                                                                                                                           
[13586] "Diffuse"                                                                                                                                                              
[13587] "Undifferentiated"                                                                                                                                                     
[13588] "Adenovirus"                                                                                                                                                           
[13589] "Amphibian"                                                                                                                                                            
[13590] "Animal_Virus"                                                                                                                                                         
[13591] "Animal"                                                                                                                                                               
[13592] "Laboratory_Animal"                                                                                                                                                    
[13593] "Transgenic_Animal"                                                                                                                                                    
[13594] "Armadillo"                                                                                                                                                            
[13595] "Alpharetrovirus"                                                                                                                                                      
[13596] "Bacteria"                                                                                                                                                             
[13597] "Bacteriophage"                                                                                                                                                        
[13598] "Bird"                                                                                                                                                                 
[13599] "Bovine_Papillomavirus"                                                                                                                                                
[13600] "Cat"                                                                                                                                                                  
[13601] "Cow"                                                                                                                                                                  
[13602] "Chicken"                                                                                                                                                              
[13603] "Chimera"                                                                                                                                                              
[13604] "Cryptococcus_neoformans"                                                                                                                                              
[13605] "Cytomegalovirus"                                                                                                                                                      
[13606] "Flies"                                                                                                                                                                
[13607] "Disease_Vector"                                                                                                                                                       
[13608] "DNA_Tumor_Virus"                                                                                                                                                      
[13609] "DNA_Virus"                                                                                                                                                            
[13610] "Dog"                                                                                                                                                                  
[13611] "Drosophila"                                                                                                                                                           
[13612] "Enterovirus"                                                                                                                                                          
[13613] "Epstein-Barr_Virus"                                                                                                                                                   
[13614] "Equine_Infectious_Anemia_Virus"                                                                                                                                       
[13615] "Escherichia_coli"                                                                                                                                                     
[13616] "Fish"                                                                                                                                                                 
[13617] "Flavivirus"                                                                                                                                                           
[13618] "Fungi"                                                                                                                                                                
[13619] "Goat"                                                                                                                                                                 
[13620] "Guinea_Pig"                                                                                                                                                           
[13621] "Hamster"                                                                                                                                                              
[13622] "Hantavirus"                                                                                                                                                           
[13623] "Hepadnavirus"                                                                                                                                                         
[13624] "Hepatitis_B_Virus"                                                                                                                                                    
[13625] "Hepatitis_Virus"                                                                                                                                                      
[13626] "Herpesvirus"                                                                                                                                                          
[13627] "Human_Herpesvirus_6"                                                                                                                                                  
[13628] "Human_Immunodeficiency_Virus"                                                                                                                                         
[13629] "Human_Immunodeficiency_Virus_1"                                                                                                                                       
[13630] "Human_Immunodeficiency_Virus_2"                                                                                                                                       
[13631] "Horse"                                                                                                                                                                
[13632] "HTLV-1"                                                                                                                                                               
[13633] "HTLV-2"                                                                                                                                                               
[13634] "Human"                                                                                                                                                                
[13635] "Human_Papillomavirus"                                                                                                                                                 
[13636] "Insect"                                                                                                                                                               
[13637] "Invertebrate"                                                                                                                                                         
[13638] "JC_Virus"                                                                                                                                                             
[13639] "Lymphocytic_Choriomeningitis_Virus"                                                                                                                                   
[13640] "Macaque"                                                                                                                                                              
[13641] "Cynomolgus_Monkey"                                                                                                                                                    
[13642] "Rhesus_Monkey"                                                                                                                                                        
[13643] "Mammal"                                                                                                                                                               
[13644] "Mouse_Mammary_Tumor_Virus"                                                                                                                                            
[13645] "Mason-Pfizer_Monkey_Virus"                                                                                                                                            
[13646] "Measles_Virus"                                                                                                                                                        
[13647] "Mouse"                                                                                                                                                                
[13648] "Nude_Mouse"                                                                                                                                                           
[13649] "Transgenic_Mouse"                                                                                                                                                     
[13650] "Moloney_Leukemia_Virus"                                                                                                                                               
[13651] "Moloney_Sarcoma_Virus"                                                                                                                                                
[13652] "Monkey"                                                                                                                                                               
[13653] "Mouse_Leukemia_Virus"                                                                                                                                                 
[13654] "Mumps_Virus"                                                                                                                                                          
[13655] "Muridae"                                                                                                                                                              
[13656] "Avian_Myeloblastosis_Virus"                                                                                                                                           
[13657] "Nematodes"                                                                                                                                                            
[13658] "Tumor_Virus"                                                                                                                                                          
[13659] "Organisms"                                                                                                                                                            
[13660] "Papillomavirus"                                                                                                                                                       
[13661] "Baboon"                                                                                                                                                               
[13662] "Papovavirus"                                                                                                                                                          
[13663] "Human_Parainfluenza_Virus_1"                                                                                                                                          
[13664] "Paramyxoviridae"                                                                                                                                                      
[13665] "Picornavirus"                                                                                                                                                         
[13666] "Plant_Virus"                                                                                                                                                          
[13667] "Plant"                                                                                                                                                                
[13668] "Poliovirus"                                                                                                                                                           
[13669] "Polyomavirus"                                                                                                                                                         
[13670] "Poxvirus"                                                                                                                                                             
[13671] "Primate"                                                                                                                                                              
[13672] "Prokaryote"                                                                                                                                                           
[13673] "Rabbit"                                                                                                                                                               
[13674] "Frog"                                                                                                                                                                 
[13675] "Rat"                                                                                                                                                                  
[13676] "Respiratory_Syncytial_Virus"                                                                                                                                          
[13677] "Retroviridae"                                                                                                                                                         
[13678] "RNA_Virus"                                                                                                                                                            
[13679] "Rodent"                                                                                                                                                               
[13680] "Saccharomyces_cerevisiae"                                                                                                                                             
[13681] "Serratia_marcescens"                                                                                                                                                  
[13682] "Sheep"                                                                                                                                                                
[13683] "Simian_Immunodeficiency_Virus"                                                                                                                                        
[13684] "Specific_Pathogen_Free_Organism"                                                                                                                                      
[13685] "Spleen_Focus-Forming_Virus"                                                                                                                                           
[13686] "Simian_T-Lymphotropic_Virus_Type_I"                                                                                                                                   
[13687] "Streptomyces"                                                                                                                                                         
[13688] "SV40"                                                                                                                                                                 
[13689] "Pig"                                                                                                                                                                  
[13690] "Vaccinia_Virus"                                                                                                                                                       
[13691] "Vertebrate"                                                                                                                                                           
[13692] "Virus"                                                                                                                                                                
[13693] "Woman"                                                                                                                                                                
[13694] "Xenopus"                                                                                                                                                              
[13695] "Yeast"                                                                                                                                                                
[13696] "Zebrafish"                                                                                                                                                            
[13697] "Feline_Immunodeficiency_Virus"                                                                                                                                        
[13698] "Helicobacter_pylori"                                                                                                                                                  
[13699] "Lentivirus"                                                                                                                                                           
[13700] "Betaretrovirus"                                                                                                                                                       
[13701] "Type_D_Retrovirus"                                                                                                                                                    
[13702] "Spumavirus"                                                                                                                                                           
[13703] "SCID_Mouse"                                                                                                                                                           
[13704] "Hepatitis_E_Virus"                                                                                                                                                    
[13705] "Helicobacter"                                                                                                                                                         
[13706] "Chimpanzee"                                                                                                                                                           
[13707] "HTLV_Virus"                                                                                                                                                           
[13708] "Parvovirus"                                                                                                                                                           
[13709] "Rous_Sarcoma_Virus"                                                                                                                                                   
[13710] "Bacteriophage_P1"                                                                                                                                                     
[13711] "Bacteriophage_T4"                                                                                                                                                     
[13712] "Caenorhabditis_elegans"                                                                                                                                               
[13713] "Calicivirus"                                                                                                                                                          
[13714] "Gammaretrovirus"                                                                                                                                                      
[13715] "Arenavirus"                                                                                                                                                           
[13716] "Paramyxovirinae"                                                                                                                                                      
[13717] "Pneumovirinae"                                                                                                                                                        
[13718] "Morbillivirus"                                                                                                                                                        
[13719] "Paramyxovirus"                                                                                                                                                        
[13720] "Herpes_Simplex_Virus"                                                                                                                                                 
[13721] "Hepatitis_C_Virus"                                                                                                                                                    
[13722] "Equidae"                                                                                                                                                              
[13723] "SENCAR_Mouse"                                                                                                                                                         
[13724] "Canarypox_Virus"                                                                                                                                                      
[13725] "Infectious_Agent"                                                                                                                                                     
[13726] "Human_Virus"                                                                                                                                                          
[13727] "Ovine_Jaagziekte_Virus"                                                                                                                                               
[13728] "Human_Papillomavirus-6"                                                                                                                                               
[13729] "Poikilotherms"                                                                                                                                                        
[13730] "Felidae"                                                                                                                                                              
[13731] "Suidae"                                                                                                                                                               
[13732] "Bovidae"                                                                                                                                                              
[13733] "Virus-like_Particle"                                                                                                                                                  
[13734] "Hepatitis_A_Virus"                                                                                                                                                    
[13735] "Rubulavirus"                                                                                                                                                          
[13736] "Human_Herpesvirus_8"                                                                                                                                                  
[13737] "Hepatitis_G_Virus"                                                                                                                                                    
[13738] "Microorganism"                                                                                                                                                        
[13739] "Helicobacter_felis"                                                                                                                                                   
[13740] "Canidae"                                                                                                                                                              
[13741] "Avian_Leukemia_Sarcoma_Virus"                                                                                                                                         
[13742] "Marine_Organism"                                                                                                                                                      
[13743] "Endogenous_Retrovirus"                                                                                                                                                
[13744] "Vascular_Plant"                                                                                                                                                       
[13745] "Bovine_Papillomavirus-1"                                                                                                                                              
[13746] "Human_Papillomavirus-16"                                                                                                                                              
[13747] "Knock-Out_Mouse"                                                                                                                                                      
[13748] "Non-Vascular_Plant"                                                                                                                                                   
[13749] "Primate_Retrovirus"                                                                                                                                                   
[13750] "PVC-211_MuLV"                                                                                                                                                         
[13751] "Non-Human_Immunodeficiency_Virus"                                                                                                                                     
[13752] "Sloan_Kettering_Virus"                                                                                                                                                
[13753] "TGF-Beta-Null_Mice"                                                                                                                                                   
[13754] "ssRNA_Virus_Strand"                                                                                                                                                   
[13755] "Deltaretrovirus"                                                                                                                                                      
[13756] "Double_Stranded_DNA_Virus"                                                                                                                                            
[13757] "Other_Virus_Grouping"                                                                                                                                                 
[13758] "Single_Stranded_DNA_Virus"                                                                                                                                            
[13759] "ssRNA_Virus_plus_Strand"                                                                                                                                              
[13760] "Consomic_Strain"                                                                                                                                                      
[13761] "Recombinants"                                                                                                                                                         
[13762] "Laboratory_Organism"                                                                                                                                                  
[13763] "Agents_of_Opportunistic_Infection"                                                                                                                                    
[13764] "Infectious_Agent_Bacteria"                                                                                                                                            
[13765] "Infectious_Agent_Virus"                                                                                                                                               
[13766] "Leporidae"                                                                                                                                                            
[13767] "Invertebrates_Land"                                                                                                                                                   
[13768] "Invertebrates_Marine"                                                                                                                                                 
[13769] "Foamy_Retrovirus"                                                                                                                                                     
[13770] "Friend_Murine_Leukemia_Virus"                                                                                                                                         
[13771] "NSF_N_Mice"                                                                                                                                                           
[13772] "Herpes_Genital_Virus"                                                                                                                                                 
[13773] "Congenic_Strain"                                                                                                                                                      
[13774] "Man"                                                                                                                                                                  
[13775] "Latent_Virus"                                                                                                                                                         
[13776] "Lytic_Virus"                                                                                                                                                          
[13777] "Lower_Organism"                                                                                                                                                       
[13778] "Sexually_Transmitted_Agents"                                                                                                                                          
[13779] "Oncornavirus"                                                                                                                                                         
[13780] "Inbred_Recombinant_Congenic_Mouse_Strains"                                                                                                                            
[13781] "Consomic_Mouse_Strain"                                                                                                                                                
[13782] "Recombinant_Inbred_Strain"                                                                                                                                            
[13783] "Escape_Mutant"                                                                                                                                                        
[13784] "Other_Organism_Groupings"                                                                                                                                             
[13785] "Human_Papillomavirus-18"                                                                                                                                              
[13786] "Corynebacterium_parvum"                                                                                                                                               
[13787] "Mistletoe"                                                                                                                                                            
[13788] "WN_Rat_Strain"                                                                                                                                                        
[13789] "SD_Rij_Rat_Strain"                                                                                                                                                    
[13790] "OM_Rat_Strain"                                                                                                                                                        
[13791] "LOU_C_Rat_Strain"                                                                                                                                                     
[13792] "HMT_Rat_Strain"                                                                                                                                                       
[13793] "DA_Rat_Strain"                                                                                                                                                        
[13794] "BDVI_Rat_Strain"                                                                                                                                                      
[13795] "BDIX_Rat_Strain"                                                                                                                                                      
[13796] "BDII_Rat_Strain"                                                                                                                                                      
[13797] "A990_Rat_Strain"                                                                                                                                                      
[13798] "WF_Rat_Strain"                                                                                                                                                        
[13799] "W_Nhg_Rat_Strain"                                                                                                                                                     
[13800] "ACI_Rat_Strain"                                                                                                                                                       
[13801] "A28807_Rat_Strain"                                                                                                                                                    
[13802] "BB_Rat_Strain"                                                                                                                                                        
[13803] "BN_Rat_Strain"                                                                                                                                                        
[13804] "BUF_Rat_Strain"                                                                                                                                                       
[13805] "COP_Rat_Strain"                                                                                                                                                       
[13806] "CRDH_Rat_Strain"                                                                                                                                                      
[13807] "DONRYU_Rat_Strain"                                                                                                                                                    
[13808] "E3_Rat_Strain"                                                                                                                                                        
[13809] "F344_Rat_Strain"                                                                                                                                                      
[13810] "FH_Rat_Strain"                                                                                                                                                        
[13811] "FHH_Rat_Strain"                                                                                                                                                       
[13812] "GH_Rat_Strain"                                                                                                                                                        
[13813] "IR_Rat_Strain"                                                                                                                                                        
[13814] "LEC_Rat_Strain"                                                                                                                                                       
[13815] "LEW_Rat_Strain"                                                                                                                                                       
[13816] "LH_Rat_Strain"                                                                                                                                                        
[13817] "M520_Rat_Strain"                                                                                                                                                      
[13818] "NBL_Rat_Strain"                                                                                                                                                       
[13819] "NZR_Rat_Strain"                                                                                                                                                       
[13820] "SHR_Rat_Strain"                                                                                                                                                       
[13821] "OXYS_Rat_Strain"                                                                                                                                                      
[13822] "WAG_Rat_Strain"                                                                                                                                                       
[13823] "OM_N_substrain"                                                                                                                                                       
[13824] "Abelson_Murine_Leukemia_Virus"                                                                                                                                        
[13825] "Rat_Strains"                                                                                                                                                          
[13826] "Wild_Type_Mouse"                                                                                                                                                      
[13827] "Organism_Strains"                                                                                                                                                     
[13828] "Mouse_Strains"                                                                                                                                                        
[13829] "Inbred_Mouse"                                                                                                                                                         
[13830] "FVB"                                                                                                                                                                  
[13831] "_129Sv_ImJ"                                                                                                                                                           
[13832] "C57BL_6"                                                                                                                                                              
[13833] "Swiss_Mice_sdc"                                                                                                                                                       
[13834] "CJ_Lynch_Rockefeller_Inst_1926"                                                                                                                                       
[13835] "SWR_J_Mouse"                                                                                                                                                          
[13836] "LT_Webster_1932_sdc"                                                                                                                                                  
[13837] "CJ_Lynch_1926_plus_LT_Webster_1932_Mouse"                                                                                                                             
[13838] "Da_HuSn_Mouse"                                                                                                                                                        
[13839] "Castle_Strains"                                                                                                                                                       
[13840] "Swiss_Strains"                                                                                                                                                        
[13841] "China_and_Japan_Colony_Strains"                                                                                                                                       
[13842] "C57-related_Strains"                                                                                                                                                  
[13843] "Multiple_Inbred_Strains"                                                                                                                                              
[13844] "Wild_Mice_Strains"                                                                                                                                                    
[13845] "Swiss_Albinos_City_of_Hope_Med_Ctr_CA"                                                                                                                                
[13846] "Unknown_Dealer"                                                                                                                                                       
[13847] "Non_Inbred_Swiss_Albino"                                                                                                                                              
[13848] "Commercial_Swiss_Albino"                                                                                                                                              
[13849] "SHN_Mouse"                                                                                                                                                            
[13850] "SLN_Mouse"                                                                                                                                                            
[13851] "SWM_Ms_Mouse"                                                                                                                                                         
[13852] "SWJ_Mouse"                                                                                                                                                            
[13853] "Pasteur_Inst"                                                                                                                                                         
[13854] "TB_Orl_Mouse"                                                                                                                                                         
[13855] "CJ_Lynch_1926_Rockefeller_Inst"                                                                                                                                       
[13856] "SJL_J_Mouse"                                                                                                                                                          
[13857] "DA_Hu_Mouse"                                                                                                                                                          
[13858] "LT_Webster_1932"                                                                                                                                                      
[13859] "TS_Hauschka_Fox_Chase_Ha_ICR"                                                                                                                                         
[13860] "Q_S_Mouse"                                                                                                                                                            
[13861] "IQl_Mouse"                                                                                                                                                            
[13862] "ICW_Mouse"                                                                                                                                                            
[13863] "ICGN_Mouse"                                                                                                                                                           
[13864] "ICR"                                                                                                                                                                  
[13865] "ICR_Bc_Mouse"                                                                                                                                                         
[13866] "NSY_Mouse"                                                                                                                                                            
[13867] "CTS"                                                                                                                                                                  
[13868] "NON_Mouse"                                                                                                                                                            
[13869] "NOD"                                                                                                                                                                  
[13870] "NOR2_Lt_Mouse"                                                                                                                                                        
[13871] "NOR1_Lt_Mouse"                                                                                                                                                        
[13872] "IMVS_Mouse"                                                                                                                                                           
[13873] "CD-1_ICR_plus_H2440"                                                                                                                                                  
[13874] "ARC_Mouse"                                                                                                                                                            
[13875] "MS_Ae_Mouse"                                                                                                                                                          
[13876] "SEN_Mouse"                                                                                                                                                            
[13877] "Swiss-Webster"                                                                                                                                                        
[13878] "NMRI"                                                                                                                                                                 
[13879] "N_NIH_early_40s"                                                                                                                                                      
[13880] "HSFR_N_Mouse"                                                                                                                                                         
[13881] "HSFS_N"                                                                                                                                                               
[13882] "FVB_N"                                                                                                                                                                
[13883] "NU_J_Mouse"                                                                                                                                                           
[13884] "NIH_Mouse"                                                                                                                                                            
[13885] "NGP_Mouse"                                                                                                                                                            
[13886] "NFS_Mouse"                                                                                                                                                            
[13887] "NFR_Mouse"                                                                                                                                                            
[13888] "YPC_Mouse"                                                                                                                                                            
[13889] "IAH_Mouse"                                                                                                                                                            
[13890] "CB_Casas_Puerto_Rico_Unpedigreed_Swiss_1948"                                                                                                                          
[13891] "TM_Mouse"                                                                                                                                                             
[13892] "Swiss"                                                                                                                                                                
[13893] "STU_Mouse"                                                                                                                                                            
[13894] "Kuhrning_Outbred_Swiss_Mice_Haffkin_Med_Sci_Inst"                                                                                                                     
[13895] "LIBP_I-4_Mouse"                                                                                                                                                       
[13896] "ICR_Mice"                                                                                                                                                             
[13897] "PIC_Mouse"                                                                                                                                                            
[13898] "Non_Inbred_Germ-free_Swiss_Mice_Lobun_Ins_Notre_Dame_1963"                                                                                                            
[13899] "ND2_RiJ_Mouse"                                                                                                                                                        
[13900] "Swiss_Albino_Sandoz_Basel_Bxs_1964"                                                                                                                                   
[13901] "SIM_Mouse"                                                                                                                                                            
[13902] "Dealer_Swiss_Albino_H_Frings_Penn_State_1953"                                                                                                                         
[13903] "RB_Mouse"                                                                                                                                                             
[13904] "Swiss_City_of_Hope_Med_Ctr_Duarte_CA"                                                                                                                                 
[13905] "HLS_Mouse"                                                                                                                                                            
[13906] "U_California"                                                                                                                                                         
[13907] "Jcl_ICR-Cts_Nihon_CLEA_1966"                                                                                                                                          
[13908] "CTA_Mouse"                                                                                                                                                            
[13909] "Swiss-Webster_X_C3H_HeAnl-Cas1_SM_Singh_1983"                                                                                                                         
[13910] "SXC_Mouse"                                                                                                                                                            
[13911] "Outbred_Swiss_X_A2"                                                                                                                                                   
[13912] "SL_Qdj_Mouse"                                                                                                                                                         
[13913] "AKR_J_Mouse"                                                                                                                                                          
[13914] "LT_Webster_Rockefeller_Inst_1933"                                                                                                                                     
[13915] "CPB-S_Mouse"                                                                                                                                                          
[13916] "China_Strain"                                                                                                                                                         
[13917] "A_y_Stock"                                                                                                                                                            
[13918] "YBR_Mouse"                                                                                                                                                            
[13919] "A_Lathrop_Grandby_1903-1915"                                                                                                                                          
[13920] "MA_MyJ_Mouse"                                                                                                                                                         
[13921] "EC_MacDowell_1921_CSH"                                                                                                                                                
[13922] "LT_Mouse"                                                                                                                                                             
[13923] "C58_J_Mouse"                                                                                                                                                          
[13924] "CC_Little_1921"                                                                                                                                                       
[13925] "Brown_Subline"                                                                                                                                                        
[13926] "BBT_Mouse"                                                                                                                                                            
[13927] "C57L_J_Mouse"                                                                                                                                                         
[13928] "C57BR_Jax_Substrains"                                                                                                                                                 
[13929] "MY_Mouse"                                                                                                                                                             
[13930] "C57_Mouse"                                                                                                                                                            
[13931] "Black_Subline_Prior_to_1937"                                                                                                                                          
[13932] "FSB_Mouse"                                                                                                                                                            
[13933] "C57BL_10_Jax_Snell_Substrains"                                                                                                                                        
[13934] "NBL_Mouse"                                                                                                                                                            
[13935] "C5yBL_10Gn"                                                                                                                                                           
[13936] "TF_Mouse"                                                                                                                                                             
[13937] "SH1_Mouse"                                                                                                                                                            
[13938] "TP_Mouse"                                                                                                                                                             
[13939] "AE_Mouse"                                                                                                                                                             
[13940] "AEJ_Mouse"                                                                                                                                                            
[13941] "V_Mouse"                                                                                                                                                              
[13942] "EBT_Mouse"                                                                                                                                                            
[13943] "LS_Le_Mouse"                                                                                                                                                          
[13944] "C57BL_6_Jax_Kaliss_Substrains"                                                                                                                                        
[13945] "C57_lcr_Mouse"                                                                                                                                                        
[13946] "BT_Os_Mouse"                                                                                                                                                          
[13947] "H1_Mouse"                                                                                                                                                             
[13948] "H2_Mouse"                                                                                                                                                             
[13949] "BXSB_Mp_Mouse"                                                                                                                                                        
[13950] "IDH2_Ei_Mouse"                                                                                                                                                        
[13951] "AX_Mouse"                                                                                                                                                             
[13952] "MYD_Mouse"                                                                                                                                                            
[13953] "C57BLKS_Mouse"                                                                                                                                                        
[13954] "ES_Russell_Jax_1948"                                                                                                                                                  
[13955] "WB_Mouse"                                                                                                                                                             
[13956] "WC_Mouse"                                                                                                                                                             
[13957] "WH_Mouse"                                                                                                                                                             
[13958] "WK_Mouse"                                                                                                                                                             
[13959] "C57BL_6Ha_Mouse"                                                                                                                                                      
[13960] "PH_Re_Mouse"                                                                                                                                                          
[13961] "RSV_Le_Mouse"                                                                                                                                                         
[13962] "TSJ_Le_Mouse"                                                                                                                                                         
[13963] "SHR_Mouse"                                                                                                                                                            
[13964] "SHM_2Gn_Mouse"                                                                                                                                                        
[13965] "YS_Mouse"                                                                                                                                                             
[13966] "LC_Strong_1925-1927_12_Pr_Mice_Carrying_Various_Coat-colour_Alleles"                                                                                                  
[13967] "I_5t_Mouse"                                                                                                                                                           
[13968] "F"                                                                                                                                                                    
[13969] "FB_Mouse"                                                                                                                                                             
[13970] "N"                                                                                                                                                                    
[13971] "NH"                                                                                                                                                                   
[13972] "JK"                                                                                                                                                                   
[13973] "Tyr_C-ch_Chinchilla_X_Coat_Color_Stocks_English_Fanciers"                                                                                                             
[13974] "LP_Mouse"                                                                                                                                                             
[13975] "_101_Mouse"                                                                                                                                                           
[13976] "_102_Mouse"                                                                                                                                                           
[13977] "TJL_Remake_P_p_Tyr_c-ch_Tyr_c_1948"                                                                                                                                   
[13978] "_1969_Mouse"                                                                                                                                                          
[13979] "_129PJ-Lama2_dy_Mouse"                                                                                                                                                
[13980] "_129P1"                                                                                                                                                               
[13981] "_129P2_Mouse"                                                                                                                                                         
[13982] "PRO_Mouse"                                                                                                                                                            
[13983] "_129_Rr"                                                                                                                                                              
[13984] "_129P3_Mouse"                                                                                                                                                         
[13985] "_129_Sv"                                                                                                                                                              
[13986] "UW_Mouse"                                                                                                                                                             
[13987] "_129X1_SvJ_Mouse"                                                                                                                                                     
[13988] "_129S1"                                                                                                                                                               
[13989] "_129S2_Mouse"                                                                                                                                                         
[13990] "_129S4_Mouse"                                                                                                                                                         
[13991] "_129S3_Mouse"                                                                                                                                                         
[13992] "MJ_Evans_1969_129_SvEv"                                                                                                                                               
[13993] "_129S5"                                                                                                                                                               
[13994] "_129S6_Mouse"                                                                                                                                                         
[13995] "_129_SvEv-Gpi1_c"                                                                                                                                                     
[13996] "_129S7_Mouse"                                                                                                                                                         
[13997] "_129S8_Mouse"                                                                                                                                                         
[13998] "_1973_129_Sv-plus_PTyrc-ch_Ter_plus"                                                                                                                                  
[13999] "_129T1_Mouse"                                                                                                                                                         
[14000] "_129T2_Mouse"                                                                                                                                                         
[14001] "Strong_s_Pink-eyed_Stock"                                                                                                                                             
[14002] "I_LnJ_Mouse"                                                                                                                                                          
[14003] "BDP_J"                                                                                                                                                                
[14004] "SEA_Mouse"                                                                                                                                                            
[14005] "GD_Snell_Jax_1940s"                                                                                                                                                   
[14006] "P_J_Mouse"                                                                                                                                                            
[14007] "VM"                                                                                                                                                                   
[14008] "MB_Mouse"                                                                                                                                                             
[14009] "IM_Mouse"                                                                                                                                                             
[14010] "CC_Little_Dbr_1909"                                                                                                                                                   
[14011] "CC_Little_s_Dba_1929-30"                                                                                                                                              
[14012] "DBA_2"                                                                                                                                                                
[14013] "MK_ReJ_Mouse"                                                                                                                                                         
[14014] "DBA_1"                                                                                                                                                                
[14015] "ATEB_Le_Mouse"                                                                                                                                                        
[14016] "JW_MacArthur_7-way_Cross_1939"                                                                                                                                        
[14017] "Large_Line"                                                                                                                                                           
[14018] "JU_Mouse"                                                                                                                                                             
[14019] "Small_Line"                                                                                                                                                           
[14020] "SM_J_Mouse"                                                                                                                                                           
[14021] "SM_JH_Mouse"                                                                                                                                                          
[14022] "Strong"                                                                                                                                                               
[14023] "Stock_C"                                                                                                                                                              
[14024] "C121_Mouse"                                                                                                                                                           
[14025] "C_5t_Mouse"                                                                                                                                                           
[14026] "Stock_CH"                                                                                                                                                             
[14027] "CHI_Mouse"                                                                                                                                                            
[14028] "CKB_Mouse"                                                                                                                                                            
[14029] "C3H"                                                                                                                                                                  
[14030] "C3HA_Mouse"                                                                                                                                                           
[14031] "BLRB_Mouse"                                                                                                                                                           
[14032] "CBRB_Mouse"                                                                                                                                                           
[14033] "Stock_CB"                                                                                                                                                             
[14034] "CBA"                                                                                                                                                                  
[14035] "BRS"                                                                                                                                                                  
[14036] "BRSUNT_Mouse"                                                                                                                                                         
[14037] "CBA_Jax_Andervont_Substrains"                                                                                                                                         
[14038] "ME_Wallace_Cam_1979"                                                                                                                                                  
[14039] "PUH_Mouse"                                                                                                                                                            
[14040] "PUC_Mouse"                                                                                                                                                            
[14041] "CBA_Ca-se_Ld_limb_Deformity_Mutn_MC_Green_Jax_1959"                                                                                                                   
[14042] "LDJ_Le_Mouse"                                                                                                                                                         
[14043] "Chester_Beatty_Inst_1962"                                                                                                                                             
[14044] "CWD_Le_Mouse"                                                                                                                                                         
[14045] "IC_Le_Mouse"                                                                                                                                                          
[14046] "CBA_CaLac"                                                                                                                                                            
[14047] "AU_SsJ_Mouse"                                                                                                                                                         
[14048] "Haldane_Gruneberg_1932"                                                                                                                                               
[14049] "CBA_Bonser_Carter_Substrains_Mouse"                                                                                                                                   
[14050] "AG_Cam_Mouse"                                                                                                                                                         
[14051] "Stock_A"                                                                                                                                                              
[14052] "JJ_Bittner_1927"                                                                                                                                                      
[14053] "STAR_Mouse"                                                                                                                                                           
[14054] "AL_Mouse"                                                                                                                                                             
[14055] "A2G_Mouse"                                                                                                                                                            
[14056] "A_Br_Mouse"                                                                                                                                                           
[14057] "A_Fa_Mouse"                                                                                                                                                           
[14058] "A_J"                                                                                                                                                                  
[14059] "CL_Fr_Mouse"                                                                                                                                                          
[14060] "A_He_Mouse"                                                                                                                                                           
[14061] "A"                                                                                                                                                                    
[14062] "LPT_Le_Mouse"                                                                                                                                                         
[14063] "CC_Little"                                                                                                                                                            
[14064] "BL_Mouse"                                                                                                                                                             
[14065] "BALB_cJ"                                                                                                                                                              
[14066] "SEC_1ReJ_Mouse"                                                                                                                                                       
[14067] "RHJ_LeJ_Mouse"                                                                                                                                                        
[14068] "DC_Le_Mouse"                                                                                                                                                          
[14069] "ABJ_Le_Mouse"                                                                                                                                                         
[14070] "CC57_Substrains_Mouse"                                                                                                                                                
[14071] "L1_Mouse"                                                                                                                                                             
[14072] "DH_Mouse"                                                                                                                                                             
[14073] "C_B17_Mouse"                                                                                                                                                          
[14074] "J_Furth_1928-36_Rockefeller_Inst"                                                                                                                                     
[14075] "AKR_FuA"                                                                                                                                                              
[14076] "ACR_A_Mouse"                                                                                                                                                          
[14077] "AKR_J"                                                                                                                                                                
[14078] "T_Takeda_Kyoto_1970"                                                                                                                                                  
[14079] "SAMR4_Mouse"                                                                                                                                                          
[14080] "SAMR1_Mouse"                                                                                                                                                          
[14081] "SAMP1_Mouse"                                                                                                                                                          
[14082] "SAMP2_Mouse"                                                                                                                                                          
[14083] "SAMP3_Mouse"                                                                                                                                                          
[14084] "SAMP6_Mouse"                                                                                                                                                          
[14085] "SAMP7_Mouse"                                                                                                                                                          
[14086] "SAMP8_Mouse"                                                                                                                                                          
[14087] "SAMP9_Mouse"                                                                                                                                                          
[14088] "SAMP10_Mouse"                                                                                                                                                         
[14089] "SAMP11_Mouse"                                                                                                                                                         
[14090] "RFM_Mouse"                                                                                                                                                            
[14091] "RF_J"                                                                                                                                                                 
[14092] "NZB_BINJ_X_RF_J_R_and_C_Wimer_1981"                                                                                                                                   
[14093] "SZA_Mouse"                                                                                                                                                            
[14094] "SZB_Mouse"                                                                                                                                                            
[14095] "SZC_Mouse"                                                                                                                                                            
[14096] "Rockefeller_Inst_Heterogeneous_Stock_R_Strain"                                                                                                                        
[14097] "SC_Mouse"                                                                                                                                                             
[14098] "BSVS"                                                                                                                                                                 
[14099] "BSC_Mouse"                                                                                                                                                            
[14100] "BSCR"                                                                                                                                                                 
[14101] "BRVS"                                                                                                                                                                 
[14102] "BRVR_Mouse"                                                                                                                                                           
[14103] "European_and_US_Stocks"                                                                                                                                               
[14104] "NZW"                                                                                                                                                                  
[14105] "NZM_Mouse"                                                                                                                                                            
[14106] "NZY"                                                                                                                                                                  
[14107] "NZC"                                                                                                                                                                  
[14108] "NZX_Mouse"                                                                                                                                                            
[14109] "NZO"                                                                                                                                                                  
[14110] "NZBR_Mouse"                                                                                                                                                           
[14111] "OUBCr_Mouse"                                                                                                                                                          
[14112] "NZB"                                                                                                                                                                  
[14113] "A_Kirschbaum_Baylor_1942-52"                                                                                                                                          
[14114] "L2_Mouse"                                                                                                                                                             
[14115] "Multiple_Crosses_C57L_DBA_2_C57BL-go_129_J"                                                                                                                           
[14116] "YT_Y_Mouse"                                                                                                                                                           
[14117] "C57BL_6J_C57BR_cdJ_A_J_BALB_cJ_LG_Ckc_SM_Ckc"                                                                                                                         
[14118] "LLC_Ckc_Mouse"                                                                                                                                                        
[14119] "HLC_Ckc_Mouse"                                                                                                                                                        
[14120] "Heterogeneous_Stock_from_A_Sn_BALB_c_CBA_Ca_C57BL_6J_DBA_2_GLF_I_St_101_H"                                                                                            
[14121] "TPS_Y_Mouse"                                                                                                                                                          
[14122] "Heterogeneous_Background"                                                                                                                                             
[14123] "MWT_Le_Mouse"                                                                                                                                                         
[14124] "Crossbred_between_Japanese_and_US_Stocks"                                                                                                                             
[14125] "IXBL_Mouse"                                                                                                                                                           
[14126] "Ra_ragged_Os_oligosyndactylism_and_Pt_pintail_Stock_MC_Green_Jax_1960"                                                                                                
[14127] "ROP_Le_Mouse"                                                                                                                                                         
[14128] "M_Davisson_1984"                                                                                                                                                      
[14129] "RBJ_Mouse"                                                                                                                                                            
[14130] "Other_Inbred_Strains"                                                                                                                                                 
[14131] "Strain_Developed_from_Intercrosses_of_8_Inbred_Strains_A_AK_BALB_c_C3H_C57BL_DBA_2_IS_Bi_and_RIII"                                                                    
[14132] "LS_lbg_Mouse"                                                                                                                                                         
[14133] "H2_Recombinant_from_c57BL_X_A_F1"                                                                                                                                     
[14134] "HTI_Mouse"                                                                                                                                                            
[14135] "H2_Recombinant_from_Heterogeneous_Stock"                                                                                                                              
[14136] "HTH_Mouse"                                                                                                                                                            
[14137] "H2_Recombinant_from_c57BL_X_BALB_c_F1"                                                                                                                                
[14138] "HTG_GoSfSn_Mouse"                                                                                                                                                     
[14139] "_8_Way_Cross_1966_G_Schlager_Kansas_U"                                                                                                                                
[14140] "BPH_2Slg_Mouse"                                                                                                                                                       
[14141] "BPL_1_Mouse"                                                                                                                                                          
[14142] "BPN_3_Mouse"                                                                                                                                                          
[14143] "JC_DeFries_Colorado_U_Heterogeneous_Stock"                                                                                                                            
[14144] "LS_Mouse"                                                                                                                                                             
[14145] "ISS_Mouse"                                                                                                                                                            
[14146] "Female_Heterogeneous_Stock_Hy2_hydrocephalus-3_Mutn_H_Gruneberg_UCL_1941"                                                                                             
[14147] "HYlII_Le"                                                                                                                                                             
[14148] "GT_Le_Mouse"                                                                                                                                                          
[14149] "Hpt_hair_Patches_Mutn"                                                                                                                                                
[14150] "HPT_Le_Mouse"                                                                                                                                                         
[14151] "NBC_and_SII_Hybrids_K_Kondo_Nagoya_U_1956"                                                                                                                            
[14152] "CS_Nga"                                                                                                                                                               
[14153] "IITES_Mouse"                                                                                                                                                          
[14154] "Nishiki-nezumi_Japanese_Fancy_Mice_K_Kondo_Nagoya_1944-49"                                                                                                            
[14155] "NBC"                                                                                                                                                                  
[14156] "Hybrids_Between_KSB_and_NBR_K_Kondo_Nagoya_U_1954"                                                                                                                    
[14157] "SII"                                                                                                                                                                  
[14158] "ITES"                                                                                                                                                                 
[14159] "Ed_Murphy_Jax_1960_3_C57BL_6J_and_12_1_C3H_HeDi_and_75_0_LG_J_and_12_6_AKR_J"                                                                                         
[14160] "MRLS_MpJ_Mouse"                                                                                                                                                       
[14161] "BALB_cGa_129_CBA_and_ICR_TM_Gunn_DM_Juriloff_UBC_1991"                                                                                                                
[14162] "SELH_Mouse"                                                                                                                                                           
[14163] "MT_Davisson_Jax_Female_NMRI_X_Wild_Make"                                                                                                                              
[14164] "RBG_Dn_Mouse"                                                                                                                                                         
[14165] "Unknown_Origin"                                                                                                                                                       
[14166] "Kitasato"                                                                                                                                                             
[14167] "DHS_Mouse"                                                                                                                                                            
[14168] "Japan_Old_N_Stock"                                                                                                                                                    
[14169] "DSD_Mouse"                                                                                                                                                            
[14170] "Nobunaga_Chugal_1960"                                                                                                                                                 
[14171] "IVCE_Mouse"                                                                                                                                                           
[14172] "IVCS_Mouse"                                                                                                                                                           
[14173] "DDI_Mouse"                                                                                                                                                            
[14174] "DDK_Mouse"                                                                                                                                                            
[14175] "DD"                                                                                                                                                                   
[14176] "DTB_Mouse"                                                                                                                                                            
[14177] "Inbred_Dd_Mice"                                                                                                                                                       
[14178] "D103_MS_Mouse"                                                                                                                                                        
[14179] "DM_Mouse"                                                                                                                                                             
[14180] "DDD"                                                                                                                                                                  
[14181] "BALB_c-Hfh11nu_X_DD_1"                                                                                                                                                
[14182] "KSN_Mouse"                                                                                                                                                            
[14183] "N8"                                                                                                                                                                   
[14184] "DRC_Mouse"                                                                                                                                                            
[14185] "DDY_Mouse"                                                                                                                                                            
[14186] "DKI"                                                                                                                                                                  
[14187] "DKI-R_Mouse"                                                                                                                                                          
[14188] "KF_Mouse"                                                                                                                                                             
[14189] "FRG_Mouse"                                                                                                                                                            
[14190] "Japanese_Fancy_Mice"                                                                                                                                                  
[14191] "NC_Mouse"                                                                                                                                                             
[14192] "Various_Hybrids_1944-49"                                                                                                                                              
[14193] "NBR_Mouse"                                                                                                                                                            
[14194] "Tianjin_China"                                                                                                                                                        
[14195] "_615_Mouse"                                                                                                                                                           
[14196] "Kimaizumi_NIH_Tokyo_1954"                                                                                                                                             
[14197] "Epilepsy_Mut_Non_Inbred_Albino"                                                                                                                                       
[14198] "EL_Mouse"                                                                                                                                                             
[14199] "Kunming_Stock_Peking_Bioproducts_1972"                                                                                                                                
[14200] "AMMS_1_Mouse"                                                                                                                                                         
[14201] "Peking_Bioproducts_Inst_1962_Outbred_Kunming"                                                                                                                         
[14202] "TA2_Mouse"                                                                                                                                                            
[14203] "Tianjin_China_1956_Outbred"                                                                                                                                           
[14204] "TA1_Mouse"                                                                                                                                                            
[14205] "US_Army_Gen_Med_Lab"                                                                                                                                                  
[14206] "S_Nishida_Tohoku_U"                                                                                                                                                   
[14207] "SS_Mouse"                                                                                                                                                             
[14208] "Japanese_Fancy_Mice_2"                                                                                                                                                
[14209] "Bxs_1958"                                                                                                                                                             
[14210] "FM_Mouse"                                                                                                                                                             
[14211] "US_Army_Gen_Med_Lab_2"                                                                                                                                                
[14212] "K_Konda_Nagoya_U_1944"                                                                                                                                                
[14213] "KSB_Mouse"                                                                                                                                                            
[14214] "KK_Mouse"                                                                                                                                                             
[14215] "KR_Mouse"                                                                                                                                                             
[14216] "S_Nishida_Tohoku_U_1951"                                                                                                                                              
[14217] "AA_Mouse"                                                                                                                                                             
[14218] "Japanese_Fancy_Mice_Sendai"                                                                                                                                           
[14219] "T_Ino_1963"                                                                                                                                                           
[14220] "RR_Mouse"                                                                                                                                                             
[14221] "Four_Pairs_KM_Outbred"                                                                                                                                                
[14222] "NJS_Mouse"                                                                                                                                                            
[14223] "Developed_from_Crosses_of_CBA_A_HeNga_Dd_and_NC_Nga"                                                                                                                  
[14224] "KYF_Ms_Mouse"                                                                                                                                                         
[14225] "KYF_Hok_Mouse"                                                                                                                                                        
[14226] "Female_Kunming_Albino_X_Male_615"                                                                                                                                     
[14227] "T739_Mouse"                                                                                                                                                           
[14228] "Outbred_Jcl_dd"                                                                                                                                                       
[14229] "DDN_Mouse"                                                                                                                                                            
[14230] "DDP_Mouse"                                                                                                                                                            
[14231] "European_Origin"                                                                                                                                                      
[14232] "Wild_Mice_Trapped_in_Toulouse_France_1976_J-L_Guenet_M_M_Domesticus"                                                                                                  
[14233] "WLA_Pas_Mouse"                                                                                                                                                        
[14234] "Wild_Mice_Trapped_Sanga_Fe_Nr_Granada_Spain_L_Thaler_1978_M_Spretus"                                                                                                  
[14235] "SEG_Pas_Mouse"                                                                                                                                                        
[14236] "Wild_Mice_Trapped_Illmitz_Austria_F_Bonhomme_U_Montpellier_1981_M_M_Musculus"                                                                                         
[14237] "MAI_Pas_Mouse"                                                                                                                                                        
[14238] "Wild_Mice_Trapped_Val_Bregaglia_Grisons_SE_Switzerland_M_M_Domesticus"                                                                                                
[14239] "RBB_Dn_Mouse"                                                                                                                                                         
[14240] "Wild_Mice_Trapped_Aluba_Valley_Grisons_SE_Switzerland_M_M_Domesticus"                                                                                                 
[14241] "RBA_Dn_Mouse"                                                                                                                                                         
[14242] "Trapped_by_D_Katarnovsli_in_Serbia_1979_for_RD_Sage_UC_Berkeley_M_Hortulanus"                                                                                         
[14243] "PANCEVO_Ei_Mouse"                                                                                                                                                     
[14244] "_3_Mice_Trapped_Stockholm_Island_off_Pembrokeshire_RJ_Berry_1962_M_M_Domesticus"                                                                                      
[14245] "SK_CamEi_Mouse"                                                                                                                                                       
[14246] "Wild_Mice_Trapped_in_Lhotka_Nr_Prague_J_Forejt_1974_M_M_Musculus"                                                                                                     
[14247] "PWD_Ph_Mouse"                                                                                                                                                         
[14248] "PWB_Mouse"                                                                                                                                                            
[14249] "Wild_Mice_Trapped_in_Photka_Nr_Prague_J_Forejt_1974_M_M_Musculus"                                                                                                     
[14250] "V_Chapman_Roswell_Park"                                                                                                                                               
[14251] "PWK_Ph_Mouse"                                                                                                                                                         
[14252] "Switzerland_X_Han_NMRI_M_M_Poschiavinus"                                                                                                                              
[14253] "RBF_Dn_Mouse"                                                                                                                                                         
[14254] "RBD_Dn_Mouse"                                                                                                                                                         
[14255] "Trapped_Saldeckovce_Czech_for_RD_Sage_UC_Berkeley_1978_M_M_Musculus"                                                                                                  
[14256] "CZECHII_Ei_Mouse"                                                                                                                                                     
[14257] "Wild_Mice_Trapped_in_Puerto_Real_Spain_RD_Sage_UC_Berkeley_1978_M_Spretus"                                                                                            
[14258] "SPRET_Ei_Mouse"                                                                                                                                                       
[14259] "Wild_Mice_Trapped_General_Toshevo_Bulgaria_1980_F_Bonhomme_Montpellier_U_M_M_Musculus"                                                                                
[14260] "MBT_Pas_Mouse"                                                                                                                                                        
[14261] "Wild_Mice_Trapped_at_Montpellier_U_F_Bonhomme_1970s_M_M_Domesticus"                                                                                                   
[14262] "BFM_2_Mouse"                                                                                                                                                          
[14263] "Trapped_Santa_Fe_nr_Granada_Spain_by_Louis_Thaler_1978_M_Spretus"                                                                                                     
[14264] "SPE_Mouse"                                                                                                                                                            
[14265] "Trapped_in_Zalende_Switzerland_RD_Sage_UC_Berkeley_M_M_Domesticus"                                                                                                    
[14266] "ALENDE_Ei_Mouse"                                                                                                                                                      
[14267] "Wild_Mice_Trapped_in_Israeli_Port_D_Michie_M_M_Praetextus"                                                                                                            
[14268] "IS_cam_Mouse"                                                                                                                                                         
[14269] "African_Origin"                                                                                                                                                       
[14270] "Wild_Mice_Monastir_Tunisia_G_Lefranc_1980_M_M_Domesticus"                                                                                                             
[14271] "WMP_Pas_Mouse"                                                                                                                                                        
[14272] "Asian_Origin"                                                                                                                                                         
[14273] "Wild_Mice_Trapped_in_Thailand_JT_Marshall_M_M_Castaneus"                                                                                                              
[14274] "CASA_Rk_Mouse"                                                                                                                                                        
[14275] "CAST_Ei_Mouse"                                                                                                                                                        
[14276] "Albino_Mice_Tokyo_U_M_M_Musculus"                                                                                                                                     
[14277] "MT_Hokldr"                                                                                                                                                            
[14278] "MTH_Mouse"                                                                                                                                                            
[14279] "Japanese_Tree_Mice_M_Potter_NIH_1969_M_M_Molossinus"                                                                                                                  
[14280] "MOLF_Ei_Mouse"                                                                                                                                                        
[14281] "MOLC_Rk"                                                                                                                                                              
[14282] "MOLG_Dn_Mouse"                                                                                                                                                        
[14283] "MOLD_RK"                                                                                                                                                              
[14284] "MOLE_Mouse"                                                                                                                                                           
[14285] "Wild_Mice_Trapped_Mishima_City_Shizuoka_Prefecture_Japan_M_M_Molossinus"                                                                                              
[14286] "MSM_Mouse"                                                                                                                                                            
[14287] "Wild_Mice_Trapped_in_Anjo-City_Japan_M_M_Molossinus"                                                                                                                  
[14288] "MOA_Mouse"                                                                                                                                                            
[14289] "Wild_Mice_Trapped_Mizuho_District_Nagoya_City_Japan_M_M_Molossinus"                                                                                                   
[14290] "MOM_Mouse"                                                                                                                                                            
[14291] "Wild_Mice_Trapped_Nishiocity_Japan_1980_M_M_Molossinus"                                                                                                               
[14292] "MOL-NIS_Mouse"                                                                                                                                                        
[14293] "Japanese_Fancy_Mice_M_M_Molossinus"                                                                                                                                   
[14294] "JF1_Mouse"                                                                                                                                                            
[14295] "American_Origin"                                                                                                                                                      
[14296] "Wild_Mice_Trapped_Centerville_MD_M_M_Domesticus"                                                                                                                      
[14297] "CLA2_Cn_Mouse"                                                                                                                                                        
[14298] "CLA_Mouse"                                                                                                                                                            
[14299] "WSA_Mouse"                                                                                                                                                            
[14300] "WSB_Mouse"                                                                                                                                                            
[14301] "Wild_Pair_Trapped_in_Philadelphia_Factory_H_Winston_U_Penn_1970s_M_M_Musculus"                                                                                        
[14302] "PAA_Mouse"                                                                                                                                                            
[14303] "PAB_Mouse"                                                                                                                                                            
[14304] "PAC_Mouse"                                                                                                                                                            
[14305] "PAD_Mouse"                                                                                                                                                            
[14306] "Wild_Mice_Trapped_Pigeon_Ontario_ML_Petras_M_M_Molossinus"                                                                                                            
[14307] "DOPG_Mouse"                                                                                                                                                           
[14308] "Wild_Mice_Trapped_in_Rimac_Valley_Peru_J_Coppock_M_M_Domesticus"                                                                                                      
[14309] "PERC_Ei_Mouse"                                                                                                                                                        
[14310] "Wild_Mice_Trapped_in_Ohio_J_Bruell_Case_Western_U_Early_1960s_M_M_Domesticus"                                                                                         
[14311] "MOR2_Mouse"                                                                                                                                                           
[14312] "MOR_Mouse"                                                                                                                                                            
[14313] "Wild_Mice_Trapped_in_Rimac_Valley_Peru_J_Coppock_M_M_Domesticus_2_plus_H2732"                                                                                         
[14314] "PERU-COPPOCK_W4_Mouse"                                                                                                                                                
[14315] "_7_Breeders_Trapped_by_Olga_Attack_Peru_1961_M_M_Domesticus"                                                                                                          
[14316] "PERA_Mouse"                                                                                                                                                           
[14317] "Wild_Mice_Trapped_in_Coal_Mine_by_RL_Rudd_UC_Davis_1951_M_M_Domesticus"                                                                                               
[14318] "SF_Mouse"                                                                                                                                                             
[14319] "C57BL_Gr-Myo5ad_d-l_dilute_Lethal_Mutn_GM_Truslove_UCL_1950"                                                                                                          
[14320] "DLS_Le_Mouse"                                                                                                                                                         
[14321] "ML_Lamoreuz_Harwell_TOE_By_RW_JUN_Stock"                                                                                                                              
[14322] "DK_Lm_Mouse"                                                                                                                                                          
[14323] "Balanced_Se_plus_plus_short_Ear_Dl_dilute_Lethal_GM_Truslove"                                                                                                         
[14324] "DL_Mouse"                                                                                                                                                             
[14325] "Varicoloured_Outbreds_Carring_Dw_dwarf_California"                                                                                                                    
[14326] "OUCW_Mouse"                                                                                                                                                           
[14327] "OUBW_Mouse"                                                                                                                                                           
[14328] "OUGW_Mouse"                                                                                                                                                           
[14329] "Anna_Dex_Gliwice_1950"                                                                                                                                                
[14330] "BN_a_Mouse"                                                                                                                                                           
[14331] "BN_b_Mouse"                                                                                                                                                           
[14332] "P_Schafer_Tubingen_1958"                                                                                                                                              
[14333] "TSI_Mouse"                                                                                                                                                            
[14334] "RC_Roberts_Edinburgh_1968"                                                                                                                                            
[14335] "RNC_Mouse"                                                                                                                                                            
[14336] "Wroclaw_U_Poland"                                                                                                                                                     
[14337] "RW_Mouse"                                                                                                                                                             
[14338] "Waltzing_Mice"                                                                                                                                                        
[14339] "TRE_Ko_Mouse"                                                                                                                                                         
[14340] "KSB_NBR_Hybrids_1964"                                                                                                                                                 
[14341] "SIIT_Mouse"                                                                                                                                                           
[14342] "Non_Inbred_Yellow_Stock"                                                                                                                                              
[14343] "BLN_Mouse"                                                                                                                                                            
[14344] "Unknown_Origin_2"                                                                                                                                                     
[14345] "WHT_Mouse"                                                                                                                                                            
[14346] "Outbred_NMRI_from_Bomholtgaard_Denmark"                                                                                                                               
[14347] "BOMG_Mouse"                                                                                                                                                           
[14348] "Div_Lab_and_Res_State_Dept_Health_Albany_1930"                                                                                                                        
[14349] "DMC_Mouse"                                                                                                                                                            
[14350] "G_Bonser_Leeds_1932-36"                                                                                                                                               
[14351] "IF_Mouse"                                                                                                                                                             
[14352] "DS_Falconer_Edinburgh_Non-obese_Inbred_Stock"                                                                                                                         
[14353] "CN_Mouse"                                                                                                                                                             
[14354] "Random_Inbred_Stock_JC_DeFries_Inst_Behav_Genet_Colorado"                                                                                                             
[14355] "C1_Mouse"                                                                                                                                                             
[14356] "C2_Mouse"                                                                                                                                                             
[14357] "LC_Dunn_and_S_Gluecksohn-Waelsh_A_Einstein_Carries_Sd_Danforth_s_Short_Tail"                                                                                          
[14358] "SD_Mouse"                                                                                                                                                             
[14359] "Hygiene_Inst_Zurich"                                                                                                                                                  
[14360] "LIS_Mouse"                                                                                                                                                            
[14361] "PE_RI"                                                                                                                                                                
[14362] "_201_RI_Mouse"                                                                                                                                                        
[14363] "A_y_a"                                                                                                                                                                
[14364] "Outbred_Albino_Mice_C_Menendez_Cuba_1970"                                                                                                                             
[14365] "IOR_Hab_Mouse"                                                                                                                                                        
[14366] "PD_Forbes_Outbred_Pigmented_Mice"                                                                                                                                     
[14367] "HRA_Skh"                                                                                                                                                              
[14368] "HRA_Mouse"                                                                                                                                                            
[14369] "SP_Homan_Florida_Mouse_Fancier"                                                                                                                                       
[14370] "KI_Mouse"                                                                                                                                                             
[14371] "P_Loustalot_Ciba_Basel_1954"                                                                                                                                          
[14372] "LTS_Mouse"                                                                                                                                                            
[14373] "Hy3_Mutn_in_Guy_s_Hosp_Stock_London"                                                                                                                                  
[14374] "SUMS_Mouse"                                                                                                                                                           
[14375] "Oak_Ridge_1957_Tabby_circling_Stock"                                                                                                                                  
[14376] "LST_Mouse"                                                                                                                                                            
[14377] "Yellow_Lethal_Mice_Misima_1961"                                                                                                                                       
[14378] "AY_Mouse"                                                                                                                                                             
[14379] "LC_Strong"                                                                                                                                                            
[14380] "STR_Mouse"                                                                                                                                                            
[14381] "STR_1_Mouse"                                                                                                                                                          
[14382] "Albino_Stock_Pet_Shop_Birmingham_AL_1958"                                                                                                                             
[14383] "PBA_Mouse"                                                                                                                                                            
[14384] "PBB_Ld_Mouse"                                                                                                                                                         
[14385] "VY_Wf-a_m_a_Male_Oakridge_1965_F5"                                                                                                                                    
[14386] "AM_Mouse"                                                                                                                                                             
[14387] "VY_Wf-A_vy_aF12_GL_Wolff_Natl_Ctr_Toxicol_Res"                                                                                                                        
[14388] "Ab_Griffen_Jax"                                                                                                                                                       
[14389] "ABP_Le_Mouse"                                                                                                                                                         
[14390] "Stock_Royal_Coll_Surgeons"                                                                                                                                            
[14391] "ABH_Mouse"                                                                                                                                                            
[14392] "ABL_Mouse"                                                                                                                                                            
[14393] "JW_Wilson_Brown_U_1950s"                                                                                                                                              
[14394] "BUA_Mouse"                                                                                                                                                            
[14395] "BUB_BnJ_Mouse"                                                                                                                                                        
[14396] "Pi_Stock_Mutn_Wl_wabbler_Lethal_1948"                                                                                                                                 
[14397] "WLHR_Le_Mouse"                                                                                                                                                        
[14398] "Polydactyl_Stock_PF_Forsthoefel_Detroit_U_1973"                                                                                                                       
[14399] "PF_Mouse"                                                                                                                                                             
[14400] "JW_MacArthur_Stock_L_Butler_1949"                                                                                                                                     
[14401] "PHH_Mouse"                                                                                                                                                            
[14402] "PHL_Mouse"                                                                                                                                                            
[14403] "Random_Bred_ARC_Stock_Pre-1960"                                                                                                                                       
[14404] "VL_Mouse"                                                                                                                                                             
[14405] "JW_MacArthur_Toronto_Outbred_T_Stock"                                                                                                                                 
[14406] "TH_Mouse"                                                                                                                                                             
[14407] "TL_Mouse"                                                                                                                                                             
[14408] "Carworth_Farms"                                                                                                                                                       
[14409] "ICFW_Mouse"                                                                                                                                                           
[14410] "CFW_Mouse"                                                                                                                                                            
[14411] "CF1_Mouse"                                                                                                                                                            
[14412] "CF0_Mouse"                                                                                                                                                            
[14413] "Unknown_Origin_Rockland_USA"                                                                                                                                          
[14414] "RAP_Ko_Mouse"                                                                                                                                                         
[14415] "AL_Hagedoorn_Neth"                                                                                                                                                    
[14416] "QC_Mouse"                                                                                                                                                             
[14417] "Outbred_Mice_Carworth_Farms"                                                                                                                                          
[14418] "CFCW_Mouse"                                                                                                                                                           
[14419] "Outbred_Charles_River_USA"                                                                                                                                            
[14420] "MIW_Mouse"                                                                                                                                                            
[14421] "B6CBA-ch_congenital_Hydrocephalus_H_Gruneburg"                                                                                                                        
[14422] "CHMU_Le_Mouse"                                                                                                                                                        
[14423] "G_Rudali_Fond_Curie_1956"                                                                                                                                             
[14424] "NLC_Mouse"                                                                                                                                                            
[14425] "Seven-locus_Stock_M_Lyon_Harwell_1969"                                                                                                                                
[14426] "PT_Mouse"                                                                                                                                                             
[14427] "Dobrovlskaia-Zavadskaia_Paris_1928"                                                                                                                                   
[14428] "XVII_Mouse"                                                                                                                                                           
[14429] "XLII_Mouse"                                                                                                                                                           
[14430] "Unknown_Origin_3"                                                                                                                                                     
[14431] "X_Mouse"                                                                                                                                                              
[14432] "Outbred_TO-Crm_cream_Mutn_Harwell_1987"                                                                                                                               
[14433] "CRM_Mouse"                                                                                                                                                            
[14434] "Danish_White_Mice_MRS_Street_1932"                                                                                                                                    
[14435] "ST_Simonex_Heston_Jax_Substrains_Mouse"                                                                                                                               
[14436] "K_Mouse"                                                                                                                                                              
[14437] "LC_Strong_2"                                                                                                                                                          
[14438] "English_Fancier_before_1929"                                                                                                                                          
[14439] "DW_J_Mouse"                                                                                                                                                           
[14440] "HG_Goodale"                                                                                                                                                           
[14441] "G_Mouse"                                                                                                                                                              
[14442] "Random_Bred_Fawn-coloured_Mice_1953"                                                                                                                                  
[14443] "OUF_Mouse"                                                                                                                                                            
[14444] "Varicoloured_Random_Bred_Mice_UK_1939"                                                                                                                                
[14445] "OUYW_Mouse"                                                                                                                                                           
[14446] "Mutn_to_Sa_satin_and_Bg_beige_Oak_Ridge"                                                                                                                              
[14447] "Sb_Le_Mouse"                                                                                                                                                          
[14448] "Dealer_to_RG_Schott_1927"                                                                                                                                             
[14449] "S_Mouse"                                                                                                                                                              
[14450] "Albino_Mice"                                                                                                                                                          
[14451] "LG_J_Mouse"                                                                                                                                                           
[14452] "Female_Tfm_plus_X_Ta_Y_Male_1971"                                                                                                                                     
[14453] "TFM_Mouse"                                                                                                                                                            
[14454] "Outbred_T_Tf_plus_Tf_Stock"                                                                                                                                           
[14455] "TFH_Mouse"                                                                                                                                                            
[14456] "Dealer_1922"                                                                                                                                                          
[14457] "PL_J_Mouse"                                                                                                                                                           
[14458] "Imported_to_Australia_1928"                                                                                                                                           
[14459] "STUD_Mouse"                                                                                                                                                           
[14460] "B6D2F1J-mk_microcytic_Anemia_Mutn_MM_Dickie_Jax"                                                                                                                      
[14461] "MH_Mouse"                                                                                                                                                             
[14462] "Unknown_Origin_4"                                                                                                                                                     
[14463] "STOLI_Mouse"                                                                                                                                                          
[14464] "Non_Inbred_Obese_Stock_DS_Falconer_Edinburgh_1958"                                                                                                                    
[14465] "BA_Mouse"                                                                                                                                                             
[14466] "H_Krzanowska_Krakow_1952"                                                                                                                                             
[14467] "KP_Mouse"                                                                                                                                                             
[14468] "KE_Mouse"                                                                                                                                                             
[14469] "Outbred_Defence_Res_BD_Suffield_Alberta"                                                                                                                              
[14470] "SWV_Mouse"                                                                                                                                                            
[14471] "Albino_Mice_Hyg_INst_Zurich_1955"                                                                                                                                     
[14472] "STS_Mouse"                                                                                                                                                            
[14473] "Unknown_Origin_HG_Wolfe_Kansas_U_1970s"                                                                                                                               
[14474] "QF-5604_Mouse"                                                                                                                                                        
[14475] "QF-5612_Mouse"                                                                                                                                                        
[14476] "Outbred_Mice_NMRI_Bethesda"                                                                                                                                           
[14477] "MIG_Mouse"                                                                                                                                                            
[14478] "Jax_Grey_Lethal_Mutn"                                                                                                                                                 
[14479] "GLF_Y_Mouse"                                                                                                                                                          
[14480] "Outbred_Mice_Grumbach_Zurich"                                                                                                                                         
[14481] "MAS_Mouse"                                                                                                                                                            
[14482] "GRS_Mouse"                                                                                                                                                            
[14483] "B_Cattanach_Harwell_C3H_HeH_X_101H_F1-hpg_hypogonadal_Mutn"                                                                                                           
[14484] "HPG_Mouse"                                                                                                                                                            
[14485] "FAE_Crew_1925"                                                                                                                                                        
[14486] "HR_De_Mouse"                                                                                                                                                          
[14487] "HRS_Mouse"                                                                                                                                                            
[14488] "HR_Ri_Mouse"                                                                                                                                                          
[14489] "Inbred_Strains_Freiburg_U_1938"                                                                                                                                       
[14490] "HLG_Mouse"                                                                                                                                                            
[14491] "H_Gruneberg_Stock_Tyr_c-e_Gl_grey_Lethal_Mutn_U_Coll_London_1935"                                                                                                     
[14492] "GL_Le_Mouse"                                                                                                                                                          
[14493] "A_J-Mip_Cat_Fr_Mutn_McGill_U_1966"                                                                                                                                    
[14494] "CA_Mouse"                                                                                                                                                             
[14495] "Commercial_Dealer_Oslo"                                                                                                                                               
[14496] "WLL_Mouse"                                                                                                                                                            
[14497] "WLO_Mouse"                                                                                                                                                            
[14498] "DS_Falconer_Edinburgh"                                                                                                                                                
[14499] "NAKED_Mouse"                                                                                                                                                          
[14500] "Breeder_Albany_NY_1930"                                                                                                                                               
[14501] "NYLR_Mouse"                                                                                                                                                           
[14502] "Carworth_Farms_CF-1"                                                                                                                                                  
[14503] "NRH_Mouse"                                                                                                                                                            
[14504] "DS_Falconer_Edinburgh_2"                                                                                                                                              
[14505] "J_Mouse"                                                                                                                                                              
[14506] "JBT_Jd_Mouse"                                                                                                                                                         
[14507] "VM_X_Linkage_Marker_Stock_Moredun_Res_Inst_Edinburgh"                                                                                                                 
[14508] "LM_Mouse"                                                                                                                                                             
[14509] "MM_Mouse"                                                                                                                                                             
[14510] "Albino_Mice_NZ_Pet_Shop_1948"                                                                                                                                         
[14511] "P_Mouse"                                                                                                                                                              
[14512] "Unknown_Origin_5"                                                                                                                                                     
[14513] "RIIl_J"                                                                                                                                                               
[14514] "RIIlS_J_Mouse"                                                                                                                                                        
[14515] "Wild_Mutant_Trapped_in_Illinois_by_Knight_1920"                                                                                                                       
[14516] "DE_J_Mouse"                                                                                                                                                           
[14517] "CE_J_Mouse"                                                                                                                                                           
[14518] "Unspecified_Stock_A_Bluhm"                                                                                                                                            
[14519] "AB_Mouse"                                                                                                                                                             
[14520] "Stock_RA_Fisher_Cambridge"                                                                                                                                            
[14521] "JE_Le_Mouse"                                                                                                                                                          
[14522] "Non_Inbred_Obese_Stock_Atp7a_Mo-to_tortoise_Mutn"                                                                                                                     
[14523] "TR"                                                                                                                                                                   
[14524] "TT6_Mouse"                                                                                                                                                            
[14525] "Texas_A_and_M_Outbred_SENCAR_Stock_1970s"                                                                                                                             
[14526] "SSIN_Mouse"                                                                                                                                                           
[14527] "Iffa_Credo_France"                                                                                                                                                    
[14528] "UMDH_plus_Mouse"                                                                                                                                                      
[14529] "UMS_Mouse"                                                                                                                                                            
[14530] "Central_Proefdierenbedrijf_TNO_Holland_1950"                                                                                                                          
[14531] "CPB-X_Mouse"                                                                                                                                                          
[14532] "CPB-Q_Mouse"                                                                                                                                                          
[14533] "CPB-N_Mouse"                                                                                                                                                          
[14534] "CPB-F_Mouse"                                                                                                                                                          
[14535] "CPB-MO_Mouse"                                                                                                                                                         
[14536] "CPB-M_Mouse"                                                                                                                                                          
[14537] "CPB-T"                                                                                                                                                                
[14538] "CPB-TK_Mouse"                                                                                                                                                         
[14539] "CPB-K"                                                                                                                                                                
[14540] "CPB-WG_Mouse"                                                                                                                                                         
[14541] "CPB-H_Mouse"                                                                                                                                                          
[14542] "Utrecht"                                                                                                                                                              
[14543] "NCU_CpbU_Mouse"                                                                                                                                                       
[14544] "HC_Mouse"                                                                                                                                                             
[14545] "MOC_Mouse"                                                                                                                                                            
[14546] "FTC_Mouse"                                                                                                                                                            
[14547] "PC_CpbU_Mouse"                                                                                                                                                        
[14548] "RC_Mouse"                                                                                                                                                             
[14549] "VC_Mouse"                                                                                                                                                             
[14550] "H_Gruneberg_UCL"                                                                                                                                                      
[14551] "CPB-WV_Mouse"                                                                                                                                                         
[14552] "N_Kobozieff_Alfort_France_1949"                                                                                                                                       
[14553] "MO_Mouse"                                                                                                                                                             
[14554] "RB_8_17_1Lem_Arose_in_White_Mice_at_Inst_Med_Leningrad_Rappolovo_Nursery"                                                                                             
[14555] "RBC_Dn_Mouse"                                                                                                                                                         
[14556] "Common_Inbred_Mouse_Strains"                                                                                                                                          
[14557] "Unsorted_Inbred_Strains"                                                                                                                                              
[14558] "Common_Mouse_Strains"                                                                                                                                                 
[14559] "_129_Mouse"                                                                                                                                                           
[14560] "CD-1_Nude_Mouse"                                                                                                                                                      
[14561] "BALB_c_Nude_Mouse"                                                                                                                                                    
[14562] "NIH-III_Mouse"                                                                                                                                                        
[14563] "NU_NU_Mouse"                                                                                                                                                          
[14564] "Immunodeficient_Mouse"                                                                                                                                                
[14565] "Rag1_Mouse"                                                                                                                                                           
[14566] "Fox_Chase_SCID_Mouse"                                                                                                                                                 
[14567] "SCID_Beige_Mouse"                                                                                                                                                     
[14568] "B6_Cg-Foxn1-nu_Mouse"                                                                                                                                                 
[14569] "CBy_Cg-Foxn1-nu"                                                                                                                                                      
[14570] "CByB6F1_J-Foxn1-nu_Mouse"                                                                                                                                             
[14571] "NU_J_Foxn1-nu_Mouse"                                                                                                                                                  
[14572] "CBySmn_CB17-Prkdc-scid_J_Mouse"                                                                                                                                       
[14573] "C3Smn_CB17-Prkdc-scid_J_Mouse"                                                                                                                                        
[14574] "B6_CB17-Prkdc-scid_SzJ_Mouse"                                                                                                                                         
[14575] "NOD_CB17-Prkdc-scid_J_Mouse"                                                                                                                                          
[14576] "NOD_129S7_B6_Rag1-tm1Mom_Mouse"                                                                                                                                       
[14577] "C_129S7-Rag1-tm1Mom_Mouse"                                                                                                                                            
[14578] "B6_129-Rag1-tm1Mom_Mouse"                                                                                                                                             
[14579] "B6_129S7-Rag1-tm1Mom_Mouse"                                                                                                                                           
[14580] "Common_Rattus_Norvegicus_Strains"                                                                                                                                     
[14581] "CD80_Antigen"                                                                                                                                                         
[14582] "CD2_Antigen"                                                                                                                                                          
[14583] "HIV_Positive"                                                                                                                                                         
[14584] "Acupuncture"                                                                                                                                                          
[14585] "Adrenalectomy"                                                                                                                                                        
[14586] "Complementary_and_Alternative_Medicine"                                                                                                                               
[14587] "Amputation"                                                                                                                                                           
[14588] "Pain_Therapy"                                                                                                                                                         
[14589] "Anesthesia_Procedure"                                                                                                                                                 
[14590] "Animal_Testing_Alternatives"                                                                                                                                          
[14591] "Antimetabolite_Chemotherapy"                                                                                                                                          
[14592] "Behavioral_Intervention"                                                                                                                                              
[14593] "Behavioral_Research"                                                                                                                                                  
[14594] "Biofeedback"                                                                                                                                                          
[14595] "Biological_Therapy"                                                                                                                                                   
[14596] "Biomedical_Research"                                                                                                                                                  
[14597] "Biopsy"                                                                                                                                                               
[14598] "Needle_Biopsy"                                                                                                                                                        
[14599] "Pheresis"                                                                                                                                                             
[14600] "Blood_Transfusion"                                                                                                                                                    
[14601] "Bone_Marrow_Biopsy"                                                                                                                                                   
[14602] "Bone_Marrow_Transplantation"                                                                                                                                          
[14603] "Radiation_Brachytherapy"                                                                                                                                              
[14604] "Carcinogenicity_Test"                                                                                                                                                 
[14605] "Case-Control_Study"                                                                                                                                                   
[14606] "Surgical_Castration"                                                                                                                                                  
[14607] "Cauterization"                                                                                                                                                        
[14608] "cecostomy"                                                                                                                                                            
[14609] "Cell-free_System"                                                                                                                                                     
[14610] "Child_Development"                                                                                                                                                    
[14611] "Child_Health"                                                                                                                                                         
[14612] "Chiropractic_Medicine"                                                                                                                                                
[14613] "Nutrition_Cholesterol"                                                                                                                                                
[14614] "Clinical_Study"                                                                                                                                                       
[14615] "Clinical_Trial"                                                                                                                                                       
[14616] "Cohort_Study"                                                                                                                                                         
[14617] "Colectomy"                                                                                                                                                            
[14618] "Colon_and_Rectal_Surgery"                                                                                                                                             
[14619] "Colostomy"                                                                                                                                                            
[14620] "Multimodal_Therapy"                                                                                                                                                   
[14621] "Community_Health_Services"                                                                                                                                            
[14622] "Craniotomy"                                                                                                                                                           
[14623] "Cryosurgery"                                                                                                                                                          
[14624] "Curettage_Procedure"                                                                                                                                                  
[14625] "Cystectomy"                                                                                                                                                           
[14626] "Cystostomy"                                                                                                                                                           
[14627] "Health_Care_Delivery"                                                                                                                                                 
[14628] "Diagnosis"                                                                                                                                                            
[14629] "Dialysis"                                                                                                                                                             
[14630] "Diet"                                                                                                                                                                 
[14631] "Nutrition_Carbohydrates"                                                                                                                                              
[14632] "Nutrition_Fats"                                                                                                                                                       
[14633] "Nutrition_Fiber"                                                                                                                                                      
[14634] "Dilation_and_Curettage"                                                                                                                                               
[14635] "Dissection"                                                                                                                                                           
[14636] "Double_Blind_Study"                                                                                                                                                   
[14637] "Drug_Screening_Assay_Antitumor"                                                                                                                                       
[14638] "Embolization_Therapy"                                                                                                                                                 
[14639] "Estrogen_Replacement_Therapy"                                                                                                                                         
[14640] "Excision"                                                                                                                                                             
[14641] "Nutrition_Fats_Unsaturated"                                                                                                                                           
[14642] "Follow-up_Study"                                                                                                                                                      
[14643] "Nutrition_Food_Additives"                                                                                                                                             
[14644] "Gastrectomy"                                                                                                                                                          
[14645] "Gene_Bank"                                                                                                                                                            
[14646] "Gene_Therapy"                                                                                                                                                         
[14647] "Patient_Care"                                                                                                                                                         
[14648] "Genetic_Counseling"                                                                                                                                                   
[14649] "Genomic_Library"                                                                                                                                                      
[14650] "Health_Maintenance_Organization"                                                                                                                                      
[14651] "Health_Promotion_Salutogenesis"                                                                                                                                       
[14652] "Access_to_Care"                                                                                                                                                       
[14653] "Health_Services_Research"                                                                                                                                             
[14654] "Heart_Transplantation"                                                                                                                                                
[14655] "Heart_and_Lung_transplantation"                                                                                                                                       
[14656] "Hemodialysis"                                                                                                                                                         
[14657] "Hepatectomy"                                                                                                                                                          
[14658] "Phytotherapy_or_Herbalism"                                                                                                                                            
[14659] "Postmenopausal_Hormone_Replacement_Therapy"                                                                                                                           
[14660] "Hospice_Care"                                                                                                                                                         
[14661] "Hospital_Administration"                                                                                                                                              
[14662] "Human_Genome_Project"                                                                                                                                                 
[14663] "Hypophysectomy"                                                                                                                                                       
[14664] "Hysterectomy"                                                                                                                                                         
[14665] "Ileostomy"                                                                                                                                                            
[14666] "Immunization"                                                                                                                                                         
[14667] "Passive_Immunization"                                                                                                                                                 
[14668] "Immunodiagnosis"                                                                                                                                                      
[14669] "Immunosuppressive_Therapy"                                                                                                                                            
[14670] "Immunotherapy"                                                                                                                                                        
[14671] "in_vitro"                                                                                                                                                             
[14672] "Infant_Nutrition"                                                                                                                                                     
[14673] "Kidney_Transplantation"                                                                                                                                               
[14674] "Laparotomy"                                                                                                                                                           
[14675] "Laryngectomy"                                                                                                                                                         
[14676] "Laser_Surgery"                                                                                                                                                        
[14677] "Leukapheresis"                                                                                                                                                        
[14678] "Ligation"                                                                                                                                                             
[14679] "Liver_Transplantation"                                                                                                                                                
[14680] "Lobectomy"                                                                                                                                                            
[14681] "Longitudinal_Study"                                                                                                                                                   
[14682] "Lung_Transplantation"                                                                                                                                                 
[14683] "Lymphadenectomy"                                                                                                                                                      
[14684] "Massage"                                                                                                                                                              
[14685] "Mastectomy"                                                                                                                                                           
[14686] "Modified_Radical_Mastectomy"                                                                                                                                          
[14687] "Radical_Mastectomy"                                                                                                                                                   
[14688] "Breast_Conservation_Treatment"                                                                                                                                        
[14689] "Total_Mastectomy"                                                                                                                                                     
[14690] "Oriental_Medicine"                                                                                                                                                    
[14691] "Naturopathy"                                                                                                                                                          
[14692] "Nephrectomy"                                                                                                                                                          
[14693] "Nursing_Research"                                                                                                                                                     
[14694] "Nutritional_Assessment"                                                                                                                                               
[14695] "Nutritional_Requirements"                                                                                                                                             
[14696] "Orchiectomy"                                                                                                                                                          
[14697] "Organ_Transplantation"                                                                                                                                                
[14698] "Ostomy"                                                                                                                                                               
[14699] "Oophorectomy"                                                                                                                                                         
[14700] "Palliative_Care"                                                                                                                                                      
[14701] "Pancreas_Transplantation"                                                                                                                                             
[14702] "Pancreatectomy"                                                                                                                                                       
[14703] "Perfusion"                                                                                                                                                            
[14704] "Isolated_Perfusion"                                                                                                                                                   
[14705] "Peritoneal_Dialysis"                                                                                                                                                  
[14706] "Intraperitoneal_Infusion"                                                                                                                                             
[14707] "Pharmacokinetics"                                                                                                                                                     
[14708] "Photodynamic_Therapy"                                                                                                                                                 
[14709] "Phototherapy"                                                                                                                                                         
[14710] "Physical_Therapy"                                                                                                                                                     
[14711] "Pilot_Study"                                                                                                                                                          
[14712] "Plasmapheresis"                                                                                                                                                       
[14713] "Pneumonectomy"                                                                                                                                                        
[14714] "Primary_Prevention"                                                                                                                                                   
[14715] "Prostatectomy"                                                                                                                                                        
[14716] "Psychotherapy"                                                                                                                                                        
[14717] "Public_Health_Administration"                                                                                                                                         
[14718] "Paracentesis"                                                                                                                                                         
[14719] "Quality_Control"                                                                                                                                                      
[14720] "Radiation_Dosimetry"                                                                                                                                                  
[14721] "Radiation_Therapy"                                                                                                                                                    
[14722] "Diagnostic_Reagents_and_Test_Kits"                                                                                                                                    
[14723] "Rehabilitation"                                                                                                                                                       
[14724] "Relaxation_Therapy"                                                                                                                                                   
[14725] "Second-Look_Surgery"                                                                                                                                                  
[14726] "Reproducibility"                                                                                                                                                      
[14727] "Research"                                                                                                                                                             
[14728] "Study_Design"                                                                                                                                                         
[14729] "Research_Resources"                                                                                                                                                   
[14730] "Respiratory_Therapy"                                                                                                                                                  
[14731] "Salpingo-Oophorectomy"                                                                                                                                                
[14732] "Self_Care"                                                                                                                                                            
[14733] "Skin_Transplantation"                                                                                                                                                 
[14734] "Sperm_Banking"                                                                                                                                                        
[14735] "Lumbar_Puncture"                                                                                                                                                      
[14736] "Splenectomy"                                                                                                                                                          
[14737] "Surgical_Procedure"                                                                                                                                                   
[14738] "Digestive_System_Surgery"                                                                                                                                             
[14739] "Ophthalmologic_Surgical_Procedure"                                                                                                                                    
[14740] "Gynecological_Surgical_Procedure"                                                                                                                                     
[14741] "Urogenital_Surgical_Procedure"                                                                                                                                        
[14742] "Urologic_Surgical_Procedure"                                                                                                                                          
[14743] "Technology_Assessment"                                                                                                                                                
[14744] "Testing"                                                                                                                                                              
[14745] "Thoracotomy"                                                                                                                                                          
[14746] "Thrombolytic_Therapy"                                                                                                                                                 
[14747] "Tissue_Collection"                                                                                                                                                    
[14748] "Total_Pancreatectomy"                                                                                                                                                 
[14749] "Tracheostomy"                                                                                                                                                         
[14750] "Transplantation"                                                                                                                                                      
[14751] "Transurethral_Prostatic_Resection"                                                                                                                                    
[14752] "UV_Light_Therapy"                                                                                                                                                     
[14753] "Ureterostomy"                                                                                                                                                         
[14754] "Vaccination"                                                                                                                                                          
[14755] "Vaccine_Therapy"                                                                                                                                                      
[14756] "Vasectomy"                                                                                                                                                            
[14757] "Nutrition_Water"                                                                                                                                                      
[14758] "Total-Body_Irradiation"                                                                                                                                               
[14759] "Adoptive_Immunotherapy"                                                                                                                                               
[14760] "Pancreatic_Islet_Transplantation"                                                                                                                                     
[14761] "Self-Examination"                                                                                                                                                     
[14762] "Breast_Reconstruction"                                                                                                                                                
[14763] "Radioimmunotherapy"                                                                                                                                                   
[14764] "Whipple_procedure"                                                                                                                                                    
[14765] "Esophagectomy"                                                                                                                                                        
[14766] "Stereotaxic_Radiosurgery"                                                                                                                                             
[14767] "Salvage_Therapy"                                                                                                                                                      
[14768] "Adjuvant_Chemotherapy"                                                                                                                                                
[14769] "Fine-Needle_Aspiration"                                                                                                                                               
[14770] "Case_Study"                                                                                                                                                           
[14771] "Healthcare"                                                                                                                                                           
[14772] "Managed_Care"                                                                                                                                                         
[14773] "Outcomes_Research"                                                                                                                                                    
[14774] "Platelet_Transfusion"                                                                                                                                                 
[14775] "Risk_Assessment"                                                                                                                                                      
[14776] "Treatment"                                                                                                                                                            
[14777] "Allogeneic_Bone_Marrow_Transplantation"                                                                                                                               
[14778] "Steroid_Therapy"                                                                                                                                                      
[14779] "Cerebral_Edema_Management"                                                                                                                                            
[14780] "Smoking_Cessation_Intervention"                                                                                                                                       
[14781] "Therapeutic_Touch"                                                                                                                                                    
[14782] "Douche"                                                                                                                                                               
[14783] "Imagery"                                                                                                                                                              
[14784] "Transcendental_Meditation"                                                                                                                                            
[14785] "Immunologic_Desensitization"                                                                                                                                          
[14786] "Boron_Neutron_Capture_Therapy"                                                                                                                                        
[14787] "Teleradiology"                                                                                                                                                        
[14788] "Telemedicine"                                                                                                                                                         
[14789] "Quality_Assurance"                                                                                                                                                    
[14790] "Gamma_Knife"                                                                                                                                                          
[14791] "Special_Diet_Therapy"                                                                                                                                                 
[14792] "Surgical_Incision"                                                                                                                                                    
[14793] "Excisional_Biopsy"                                                                                                                                                    
[14794] "Incisional_Biopsy"                                                                                                                                                    
[14795] "Shave_Biopsy"                                                                                                                                                         
[14796] "Infusion"                                                                                                                                                             
[14797] "Endoscopic_Biopsy"                                                                                                                                                    
[14798] "Fulguration"                                                                                                                                                          
[14799] "Electrodesiccation"                                                                                                                                                   
[14800] "Thoracentesis"                                                                                                                                                        
[14801] "Limb_Perfusion"                                                                                                                                                       
[14802] "Partial_Hepatectomy"                                                                                                                                                  
[14803] "Autologous_Bone_Marrow_Transplantation"                                                                                                                               
[14804] "Radical_Cystectomy"                                                                                                                                                   
[14805] "Bladder_Irrigation"                                                                                                                                                   
[14806] "Urethrostomy"                                                                                                                                                         
[14807] "Radical_Prostatectomy"                                                                                                                                                
[14808] "Perineal_Prostatectomy"                                                                                                                                               
[14809] "Retropubic_Prostatectomy"                                                                                                                                             
[14810] "Conization"                                                                                                                                                           
[14811] "Endocervical_Curettage"                                                                                                                                               
[14812] "Mediastinotomy"                                                                                                                                                       
[14813] "Prevention"                                                                                                                                                           
[14814] "Cancer_Screening"                                                                                                                                                     
[14815] "Family_Study"                                                                                                                                                         
[14816] "Transfusion"                                                                                                                                                          
[14817] "Packed_Red_Blood_Cell_Transfusion"                                                                                                                                    
[14818] "Biological_Response_Modifier_Therapy"                                                                                                                                 
[14819] "Cytokine_Therapy"                                                                                                                                                     
[14820] "Lymphokine-Activated_Killer_Cell_Therapy"                                                                                                                             
[14821] "Fertility_Study"                                                                                                                                                      
[14822] "ADCC_Assay"                                                                                                                                                           
[14823] "Hyperthermia_Treatment"                                                                                                                                               
[14824] "Active_Immunization"                                                                                                                                                  
[14825] "Randomized_Clinical_Trial"                                                                                                                                            
[14826] "Sargramostim_Thiotepa"                                                                                                                                                
[14827] "Screening"                                                                                                                                                            
[14828] "Hypnotherapy"                                                                                                                                                         
[14829] "Postmenopausal"                                                                                                                                                       
[14830] "Human_Migration"                                                                                                                                                      
[14831] "Psychosocial_Rehabilitation"                                                                                                                                          
[14832] "Record_Linkage_Study"                                                                                                                                                 
[14833] "Supplementation"                                                                                                                                                      
[14834] "Database"                                                                                                                                                             
[14835] "Lymph_Node_Dissection"                                                                                                                                                
[14836] "Interdisciplinary_Research"                                                                                                                                           
[14837] "Research_Activity"                                                                                                                                                    
[14838] "Peripheral_Blood_Stem_Cell_Transplantation"                                                                                                                           
[14839] "Stem_Cell_Transplantation"                                                                                                                                            
[14840] "Surveillance_Epidemiology_and_End_Results_Program"                                                                                                                    
[14841] "Nutritional_Support"                                                                                                                                                  
[14842] "Technology_Transfer"                                                                                                                                                  
[14843] "Transfer_Factor_Therapy"                                                                                                                                              
[14844] "Mind-Body_Intervention"                                                                                                                                               
[14845] "Nutrition_Food_and_Water_Contaminants"                                                                                                                                
[14846] "Cancer_Immunotherapy"                                                                                                                                                 
[14847] "PDQ_Information_System"                                                                                                                                               
[14848] "High-LET_Neutron_Therapy"                                                                                                                                             
[14849] "Interleukin-2_Poly-ICLC"                                                                                                                                              
[14850] "Interleukin-2_Zidovudine"                                                                                                                                             
[14851] "Low-LET_Cobalt-60_Gamma_Ray_Therapy"                                                                                                                                  
[14852] "Low-LET_Photon_Therapy"                                                                                                                                               
[14853] "Hormone_Therapy"                                                                                                                                                      
[14854] "Adjuvant_Study"                                                                                                                                                       
[14855] "Dietary_Intervention"                                                                                                                                                 
[14856] "Graft_Versus_Host_Disease_Prophylaxis_Therapy"                                                                                                                        
[14857] "Somatostatin_Analog_Therapy"                                                                                                                                          
[14858] "Prior_Chemotherapy_for_Advanced_Disease"                                                                                                                              
[14859] "Prior_Anthracycline_Therapy"                                                                                                                                          
[14860] "Prior_Biologic_Therapy"                                                                                                                                               
[14861] "Prior_Interferon_Therapy"                                                                                                                                             
[14862] "Head_and_Neck_Surgery"                                                                                                                                                
[14863] "Evaluation_of_Cancer_Risk_Factors"                                                                                                                                    
[14864] "Low-LET_Implant_Therapy"                                                                                                                                              
[14865] "Low-LET_Electron_Therapy"                                                                                                                                             
[14866] "High-LET_Heavy_Ion_Therapy"                                                                                                                                           
[14867] "High-LET_Pion_Therapy"                                                                                                                                                
[14868] "Mixed_High-Low_LET_Therapy"                                                                                                                                           
[14869] "Non-Specific_Immune-Modulator_Therapy"                                                                                                                                
[14870] "in_vitro-Treated_Bone_Marrow_Transplantation"                                                                                                                         
[14871] "Chemosensitization"                                                                                                                                                   
[14872] "Radiosensitization"                                                                                                                                                   
[14873] "Syngeneic_Bone_Marrow_Transplantation"                                                                                                                                
[14874] "Laser_Therapy"                                                                                                                                                        
[14875] "Ablative_Endocrine_Surgery"                                                                                                                                           
[14876] "Depigmentation_Therapy"                                                                                                                                               
[14877] "Interferon_Therapy"                                                                                                                                                   
[14878] "Isotope_Therapy"                                                                                                                                                      
[14879] "Replacement_Therapy"                                                                                                                                                  
[14880] "Adrenal_Blockade"                                                                                                                                                     
[14881] "Nausea_and_Vomiting_Therapy"                                                                                                                                          
[14882] "Hematologic_Toxicity_Attenuation"                                                                                                                                     
[14883] "Radioprotection"                                                                                                                                                      
[14884] "Complications_of_Therapy_Assessment"                                                                                                                                  
[14885] "Prior_Radiation_Therapy"                                                                                                                                              
[14886] "Group_C_Treatment_IND_Protocol"                                                                                                                                       
[14887] "Immune-Globulin_Zidovudine"                                                                                                                                           
[14888] "Sargramostim_Zidovudine"                                                                                                                                              
[14889] "Antiandrogen_Therapy"                                                                                                                                                 
[14890] "Androgen_Therapy"                                                                                                                                                     
[14891] "Estrogen_Therapy"                                                                                                                                                     
[14892] "Progestin_Therapy"                                                                                                                                                    
[14893] "Neurotoxicity_Attenuation"                                                                                                                                            
[14894] "Prostaglandin_Inhibition"                                                                                                                                             
[14895] "Hypercalcemia_Therapy"                                                                                                                                                
[14896] "Drug_Modulation"                                                                                                                                                      
[14897] "Releasing_Factor_Agonist_Therapy"                                                                                                                                     
[14898] "Monoclonal_Antibody_Therapy"                                                                                                                                          
[14899] "Premenopausal"                                                                                                                                                        
[14900] "Estrogen_Receptor_Positive"                                                                                                                                           
[14901] "Estrogen_Receptor_Negative"                                                                                                                                           
[14902] "Fatigue_Assessment_and_Management"                                                                                                                                    
[14903] "Estrogen_Receptor_Status_Unknown"                                                                                                                                     
[14904] "Progesterone_Receptor_Positive"                                                                                                                                       
[14905] "Progesterone_Receptor_Negative"                                                                                                                                       
[14906] "Progesterone_Receptor_Status_Unknown"                                                                                                                                 
[14907] "Prior_Oophorectomy"                                                                                                                                                   
[14908] "Prior_Estrogen_Therapy"                                                                                                                                               
[14909] "Prior_Antiestrogen_Therapy"                                                                                                                                           
[14910] "Prior_Progestin_Therapy"                                                                                                                                              
[14911] "Prior_LHRH_Agonist_Therapy"                                                                                                                                           
[14912] "Prior_Androgen_Therapy"                                                                                                                                               
[14913] "Peripheral_Blood_Lymphocyte_Therapy"                                                                                                                                  
[14914] "Anticachectic_Therapy"                                                                                                                                                
[14915] "Tumor_Necrosis_Factor_Therapy"                                                                                                                                        
[14916] "Antibody_Conjugate_Therapy"                                                                                                                                           
[14917] "Amino_Acid_Injection"                                                                                                                                                 
[14918] "Growth_Factor_Antagonist_Therapy"                                                                                                                                     
[14919] "Infection_Prophylaxis_and_Management"                                                                                                                                 
[14920] "Prior_Endocrine_Therapy_for_Advanced_Disease"                                                                                                                         
[14921] "Drug_Extravasation_Therapy"                                                                                                                                           
[14922] "Psychosocial_Assessment_and_Care"                                                                                                                                     
[14923] "Colony-Stimulating_Factor_Therapy"                                                                                                                                    
[14924] "Fertility_Assessment_and_Management"                                                                                                                                  
[14925] "Catheter_Management"                                                                                                                                                  
[14926] "Clinical_Trials_Information_for_Patients"                                                                                                                             
[14927] "Clinical_Trials_Information_for_Physicians"                                                                                                                           
[14928] "Flavone-Acetic-Acid_Interleukin-2"                                                                                                                                    
[14929] "Antiprogestational_Therapy"                                                                                                                                           
[14930] "Interleukin-2_Tumor-Necrosis-Factor"                                                                                                                                  
[14931] "Interleukin-2_Tumor-Infiltrating-Lymphocytes"                                                                                                                         
[14932] "Tumor_Infiltrating_Lymphocyte_Therapy"                                                                                                                                
[14933] "Aromatase_Inhibition"                                                                                                                                                 
[14934] "_5a-Reductase_Inhibition"                                                                                                                                             
[14935] "Interleukin-2_Sargramostim"                                                                                                                                           
[14936] "Interleukin-2_Monoclonal-Antibody-Lym-1"                                                                                                                              
[14937] "Bone_Metastases_Prevention"                                                                                                                                           
[14938] "Interleukin-2_Monoclonal-Antibody-R24"                                                                                                                                
[14939] "Monoclonal-Antibody-R24_Sargramostim"                                                                                                                                 
[14940] "in_vitro-Treated_Peripheral_Blood_Stem_Cell_Transplantation"                                                                                                          
[14941] "Chemoprotection"                                                                                                                                                      
[14942] "Cardiotoxicity_Attenuation"                                                                                                                                           
[14943] "Urothelial_Toxicity_Attenuation"                                                                                                                                      
[14944] "Bone_Marrow_Suppression"                                                                                                                                              
[14945] "Macrophage_Colony-Stimulating_Factor_Monoclonal_Antibody_R24"                                                                                                         
[14946] "Protocol_Treatment_Arm"                                                                                                                                               
[14947] "Treatment_Referral_Center_Protocol"                                                                                                                                   
[14948] "Antiprolactin_Therapy"                                                                                                                                                
[14949] "Sleep_Disorders_Therapy"                                                                                                                                              
[14950] "Antibody_Therapy"                                                                                                                                                     
[14951] "Interleukin_Therapy"                                                                                                                                                  
[14952] "Anti-Cytokine_Therapy"                                                                                                                                                
[14953] "Leukocyte_Therapy"                                                                                                                                                    
[14954] "Breast_Cancer_Screening"                                                                                                                                              
[14955] "Screening_for_Skin_Cancer"                                                                                                                                            
[14956] "Screening_for_Oral_Cancer"                                                                                                                                            
[14957] "Screening_for_Colorectal_Cancer"                                                                                                                                      
[14958] "Screening_for_Prostate_Cancer"                                                                                                                                        
[14959] "Cervical_Cancer_Screening"                                                                                                                                            
[14960] "Screening_for_Testicular_Cancer"                                                                                                                                      
[14961] "Breast_Cancer_Prevention"                                                                                                                                             
[14962] "Prevention_of_Colorectal_Cancer"                                                                                                                                      
[14963] "Prevention_of_Head_and_Neck_Cancer"                                                                                                                                   
[14964] "Prevention_of_Skin_Cancer"                                                                                                                                            
[14965] "Prevention_of_Cervical_Cancer"                                                                                                                                        
[14966] "Prevention_of_Lung_Cancer"                                                                                                                                            
[14967] "Prevention_of_Esophageal_Cancer"                                                                                                                                      
[14968] "Interleukin-3_Thiotepa"                                                                                                                                               
[14969] "Cancer_Prevention_Intervention"                                                                                                                                       
[14970] "Interleukin-3_Melphalan"                                                                                                                                              
[14971] "Interleukin-3_Zidovudine"                                                                                                                                             
[14972] "Prior_Adjuvant_Chemotherapy"                                                                                                                                          
[14973] "Prior_Adjuvant_Endocrine_Hormonal_Therapy"                                                                                                                            
[14974] "Neoadjuvant_Study"                                                                                                                                                    
[14975] "Screening_for_Gastric_Cancer"                                                                                                                                         
[14976] "Antiangiogenesis_Therapy"                                                                                                                                             
[14977] "Bone_Marrow_Ablation"                                                                                                                                                 
[14978] "Pressor_Support"                                                                                                                                                      
[14979] "Differentiation_Therapy"                                                                                                                                              
[14980] "Prevention_of_Prostate_Cancer"                                                                                                                                        
[14981] "Tumor-Draining_Lymph_Node_Lymphocyte_Therapy"                                                                                                                         
[14982] "Interleukin-3_Interleukin-6"                                                                                                                                          
[14983] "Screening_for_Lung_Cancer"                                                                                                                                            
[14984] "Screening_for_Ovarian_Cancer"                                                                                                                                         
[14985] "Anti-Tumor_Necrosis_Factor_Therapy"                                                                                                                                   
[14986] "in_vitro_Sensitivity-Directed_Chemotherapy"                                                                                                                           
[14987] "Interleukin-2_Tumor-Necrosis-Factor-Receptor-IgG-Chimera"                                                                                                             
[14988] "Intra-Operative_Blood_Salvage"                                                                                                                                        
[14989] "Intraperitoneal_Therapy"                                                                                                                                              
[14990] "Prevention_of_Aerodigestive_Tract_Cancer"                                                                                                                             
[14991] "Sargramostim_Tumor-Necrosis-Factor"                                                                                                                                   
[14992] "Quality-of-Life_Assessment"                                                                                                                                           
[14993] "Targeted_Fusion_Protein_Therapy"                                                                                                                                      
[14994] "BiSpecific-Antibody-520C9XH22_Interferon-Gamma"                                                                                                                       
[14995] "Bone_Marrow_Ablation_with_Stem_Cell_Support"                                                                                                                          
[14996] "Interleukin-6_Sargramostim"                                                                                                                                           
[14997] "Melphalan_Tumor-Necrosis-Factor"                                                                                                                                      
[14998] "Monoclonal-Antibody-3F8_Sargramostim"                                                                                                                                 
[14999] "Prevention_of_Ovarian_Cancer"                                                                                                                                         
[15000] "Incomplete-Freunds-Adjuvant_MART-1"                                                                                                                                   
[15001] "gp100-Antigen_Interleukin-2"                                                                                                                                          
[15002] "Interleukin-2_Monoclonal-Antibody-HuG1-M195"                                                                                                                          
[15003] "Transitional_Care_Planning"                                                                                                                                           
[15004] "Interleukin-2_Vinblastine"                                                                                                                                            
[15005] "Incomplete-Freunds-Adjuvant_Interleukin-12_MART-1-Antigen"                                                                                                            
[15006] "BiSpecific-Antibody-520C9XH22_Filgrastim"                                                                                                                             
[15007] "Hormone_Replacement_Therapy"                                                                                                                                          
[15008] "Phase_I_Trial"                                                                                                                                                        
[15009] "Phase_II_Trial"                                                                                                                                                       
[15010] "Phase_III_Trial"                                                                                                                                                      
[15011] "Phase_IV_Trial"                                                                                                                                                       
[15012] "Chemoprevention"                                                                                                                                                      
[15013] "Nutrition_Trace_Elements"                                                                                                                                             
[15014] "Acupressure"                                                                                                                                                          
[15015] "Clinical_Diagnosis"                                                                                                                                                   
[15016] "Staging"                                                                                                                                                              
[15017] "Anastomosis"                                                                                                                                                          
[15018] "Aspirin_Interferon-Alfa"                                                                                                                                              
[15019] "Interferon-Alfa_Monoclonal-Antibody-CC49"                                                                                                                             
[15020] "Interleukin-2_Monoclonal-Antibody-OKT3"                                                                                                                               
[15021] "Interleukin-2_Monoclonal-Antibody-OKT3_Tumor-Necrosis-Factor"                                                                                                         
[15022] "Interleukin-2_Monoclonal-Antibody-OKT3_Pentoxifylline"                                                                                                                
[15023] "gp100-Antigen_Incomplete-Freunds-Adjuvant"                                                                                                                            
[15024] "Monoclonal-Antibody-17-1A_sargramostim"                                                                                                                               
[15025] "Cancer_and_Suicide"                                                                                                                                                   
[15026] "Edetate-Calcium-Disodium_Interferon-Alfa_Monoclonal-Antibody-CC49"                                                                                                    
[15027] "Antibiotic_Therapy"                                                                                                                                                   
[15028] "H2_Receptor_Antagonist_Therapy"                                                                                                                                       
[15029] "Radioimmunoguided_Surgery"                                                                                                                                            
[15030] "Intraoperative_Radiation_Therapy"                                                                                                                                     
[15031] "_9-cis-Retinoic-Acid_Interferon-Alfa"                                                                                                                                 
[15032] "QS21_Tyrosinase-Peptide"                                                                                                                                              
[15033] "Neuroendocrine_Therapy"                                                                                                                                               
[15034] "Interferon-Alfa_Monoclonal-Antibody-CC49_Paclitaxel"                                                                                                                  
[15035] "Interferon-Alfa_Monoclonal-Antibody-CC49_Pentetic-Acid"                                                                                                               
[15036] "Keyhole-Limpet-Hemocyanin_MUC-1-Antigen"                                                                                                                              
[15037] "Vegan_Diet"                                                                                                                                                           
[15038] "Aspiration"                                                                                                                                                           
[15039] "Chemotherapy"                                                                                                                                                         
[15040] "Cancer_Pain_Management"                                                                                                                                               
[15041] "_70-kD-Heat-Shock-Protein_MUC-1-Antigen"                                                                                                                              
[15042] "gp100-Antigen_Incomplete-Freunds-Adjuvant_Interleukin-2"                                                                                                              
[15043] "gp100-Antigen_Incomplete-Freunds-Adjuvant_Interleukin-12"                                                                                                             
[15044] "gp100-Antigen_Interleukin-2_MART-1-Antigen"                                                                                                                           
[15045] "Genetic_Testing_for_Cancer_Risk"                                                                                                                                      
[15046] "Level_of_Evidence"                                                                                                                                                    
[15047] "Umbilical_Cord_Blood_Transplantation"                                                                                                                                 
[15048] "Screening_for_Neuroblastoma"                                                                                                                                          
[15049] "Epidural_Block"                                                                                                                                                       
[15050] "Neck_Dissection"                                                                                                                                                      
[15051] "Bone_Marrow_Aspiration"                                                                                                                                               
[15052] "Other_Therapy"                                                                                                                                                        
[15053] "Nutrition_Calories"                                                                                                                                                   
[15054] "Anterior_Mediastinotomy"                                                                                                                                              
[15055] "Continuous_Infusion"                                                                                                                                                  
[15056] "Diet_Research"                                                                                                                                                        
[15057] "Electron_Beam_Therapy"                                                                                                                                                
[15058] "High-Dose_Rate_Brachytherapy"                                                                                                                                         
[15059] "Image_Guided_Biopsy"                                                                                                                                                  
[15060] "Drug_Formulation"                                                                                                                                                     
[15061] "Fractionation"                                                                                                                                                        
[15062] "Thoracic_Surgical_Procedures"                                                                                                                                         
[15063] "Neurosurgical_Procedure"                                                                                                                                              
[15064] "Blood_Treatment"                                                                                                                                                      
[15065] "Cancer_and_Nutrition"                                                                                                                                                 
[15066] "Aging_and_Nutrition"                                                                                                                                                  
[15067] "Vaccine_Development"                                                                                                                                                  
[15068] "ATCC"                                                                                                                                                                 
[15069] "Neuroprotection"                                                                                                                                                      
[15070] "Nicotine_Gum"                                                                                                                                                         
[15071] "Technology_Development"                                                                                                                                               
[15072] "Neoadjuvant_Therapy"                                                                                                                                                  
[15073] "Radiofrequency_Interstitial_Ablation"                                                                                                                                 
[15074] "Sentinel_Lymph_Node_Biopsy"                                                                                                                                           
[15075] "Prevention_of_Liver_Cancer"                                                                                                                                           
[15076] "Cancer_Prevention"                                                                                                                                                    
[15077] "Thermal_Ablation_Therapy"                                                                                                                                             
[15078] "Screening_for_Endometrial_Cancer"                                                                                                                                     
[15079] "Hot_Flashes_Attenuation"                                                                                                                                              
[15080] "Keratinocyte_Growth_Factor_Therapy"                                                                                                                                   
[15081] "Prevention_of_Endometrial_Cancer"                                                                                                                                     
[15082] "Adjuvant_Therapy"                                                                                                                                                     
[15083] "Androgen_Suppression"                                                                                                                                                 
[15084] "Axillary_Lymph_Node_Dissection"                                                                                                                                       
[15085] "Bolus_Infusion"                                                                                                                                                       
[15086] "Consolidation_Therapy"                                                                                                                                                
[15087] "Core_Biopsy"                                                                                                                                                          
[15088] "Cytotoxic_Chemotherapy"                                                                                                                                               
[15089] "Dose-Rate"                                                                                                                                                            
[15090] "Epidural"                                                                                                                                                             
[15091] "Hyperthermic_Perfusion"                                                                                                                                               
[15092] "Incubated"                                                                                                                                                            
[15093] "Isolated_Hepatic_Perfusion"                                                                                                                                           
[15094] "Local_Therapy"                                                                                                                                                        
[15095] "Maintenance_Therapy"                                                                                                                                                  
[15096] "Drug_Resistance_Inhibition"                                                                                                                                           
[15097] "Myelosuppressive_Therapy"                                                                                                                                             
[15098] "Ovarian_Ablation"                                                                                                                                                     
[15099] "Perimenopausal"                                                                                                                                                       
[15100] "Phase_I_II_Trial"                                                                                                                                                     
[15101] "Phase_II_III_Trial"                                                                                                                                                   
[15102] "Quadrantectomy"                                                                                                                                                       
[15103] "Radiation_Surgery"                                                                                                                                                    
[15104] "Treatment_Regimen"                                                                                                                                                    
[15105] "Systemic_Therapy"                                                                                                                                                     
[15106] "T-Cell_Depletion"                                                                                                                                                     
[15107] "Total_Estrogen_Blockade"                                                                                                                                              
[15108] "Total_Hysterectomy"                                                                                                                                                   
[15109] "Video-Assisted_Surgery"                                                                                                                                               
[15110] "Colposcopic_Biopsy"                                                                                                                                                   
[15111] "Antifungal_Therapy"                                                                                                                                                   
[15112] "Transurethral_Resection"                                                                                                                                              
[15113] "Bryostatin_1_Interleukin-2_Ionomycin"                                                                                                                                 
[15114] "Electroporation_Therapy"                                                                                                                                              
[15115] "Prevention_of_Oral_Cancer"                                                                                                                                            
[15116] "Genetic_Testing"                                                                                                                                                      
[15117] "Nicotine_Replacement"                                                                                                                                                 
[15118] "Prevention_Research"                                                                                                                                                  
[15119] "Secondary_Prevention"                                                                                                                                                 
[15120] "Religion_and_Spirituality"                                                                                                                                            
[15121] "Basic_Science"                                                                                                                                                        
[15122] "Applied_Research"                                                                                                                                                     
[15123] "Population_Study"                                                                                                                                                     
[15124] "Cytogenetic_Map"                                                                                                                                                      
[15125] "Homeopathic_Remedy"                                                                                                                                                   
[15126] "Surveillance"                                                                                                                                                         
[15127] "Pharmacodynamics"                                                                                                                                                     
[15128] "Epidemiology_Research"                                                                                                                                                
[15129] "Patient_Observation"                                                                                                                                                  
[15130] "Bypass"                                                                                                                                                               
[15131] "Inguinal_Orchiectomy"                                                                                                                                                 
[15132] "Laparoscopic_Surgery"                                                                                                                                                 
[15133] "Thoracoscopic_Surgery"                                                                                                                                                
[15134] "cDNA_Library"                                                                                                                                                         
[15135] "Reiki"                                                                                                                                                                
[15136] "Sequential_Treatment"                                                                                                                                                 
[15137] "Peritoneal_Perfusion"                                                                                                                                                 
[15138] "Intrahepatic_Infusion"                                                                                                                                                
[15139] "Continuous_Hyperthermic_Peritoneal_Perfusion"                                                                                                                         
[15140] "Diagnostic_Trial"                                                                                                                                                     
[15141] "Prevention_of_Gastric_Cancer"                                                                                                                                         
[15142] "Prevention_of_Bladder_Cancer"                                                                                                                                         
[15143] "Intracarotid_Infusion"                                                                                                                                                
[15144] "Intraventricular_Infusion"                                                                                                                                            
[15145] "Dyspnea_Management"                                                                                                                                                   
[15146] "Immunotoxin_Therapy"                                                                                                                                                  
[15147] "Menopausal_Symptoms_Attenuation"                                                                                                                                      
[15148] "Screening_for_Hepatocellular_Cancer"                                                                                                                                  
[15149] "Postremission_Therapy"                                                                                                                                                
[15150] "Medical_Castration"                                                                                                                                                   
[15151] "in_vivo"                                                                                                                                                              
[15152] "Hyperfractionation"                                                                                                                                                   
[15153] "Remission_Induction_Therapy"                                                                                                                                          
[15154] "Supportive_Care"                                                                                                                                                      
[15155] "Total_Nodal_Irradiation"                                                                                                                                              
[15156] "Tumor_Debulking"                                                                                                                                                      
[15157] "Intrathecal_Chemotherapy"                                                                                                                                             
[15158] "External_Beam_Radiation"                                                                                                                                              
[15159] "Chemoembolization"                                                                                                                                                    
[15160] "Cancer_Registry"                                                                                                                                                      
[15161] "Geographic_Information_System"                                                                                                                                        
[15162] "Lumpectomy"                                                                                                                                                           
[15163] "Single_Agent_Systemic_Chemotherapy"                                                                                                                                   
[15164] "Antiestrogen_Therapy"                                                                                                                                                 
[15165] "Central_Line_Management"                                                                                                                                              
[15166] "Urostomy"                                                                                                                                                             
[15167] "Drug_Development"                                                                                                                                                     
[15168] "Acustimulation"                                                                                                                                                       
[15169] "Laparoscopic_Colectomy"                                                                                                                                               
[15170] "Advanced_Manufacturing_Technology"                                                                                                                                    
[15171] "AIDS_Clinical_Trial-AIDS-Related_Malignancie"                                                                                                                         
[15172] "AIDS_Clinical_Trials-Minority"                                                                                                                                        
[15173] "AIDS_Clinical_Trial-Opportunistic_Infection"                                                                                                                          
[15174] "AIDS_Clinical_Trials-Pediatric"                                                                                                                                       
[15175] "AIDS_Clinical_Trials-Women"                                                                                                                                           
[15176] "Basic_Behavioral_and_Social_Science_Research"                                                                                                                         
[15177] "Behavior_Research_Direct"                                                                                                                                             
[15178] "Behavior_Research_Indirect"                                                                                                                                           
[15179] "Biological_Response_Modifiers_Program"                                                                                                                                
[15180] "Blood_Banking_Leukocyte"                                                                                                                                              
[15181] "Breast_Cancer_Treatment"                                                                                                                                              
[15182] "Breast_Cancer_Detection"                                                                                                                                              
[15183] "Cancer_Detection"                                                                                                                                                     
[15184] "Cancer_Prevention_Primary"                                                                                                                                            
[15185] "Cancer_Prevention_Secondary"                                                                                                                                          
[15186] "Carcinogen_Screening"                                                                                                                                                 
[15187] "Carcinogenesis_Inhibition"                                                                                                                                            
[15188] "Carcinogenesis_Reversion"                                                                                                                                             
[15189] "Chemoprevention_Clinical"                                                                                                                                             
[15190] "Clinical_Data"                                                                                                                                                        
[15191] "Clinical_Nutrition"                                                                                                                                                   
[15192] "Clinical_Services"                                                                                                                                                    
[15193] "Clinical_Treatment"                                                                                                                                                   
[15194] "Clinical_Trial_Design"                                                                                                                                                
[15195] "Clinical_Trials_Diagnosis"                                                                                                                                            
[15196] "Clinical_Trials_Monitoring"                                                                                                                                           
[15197] "Cancer_Prevention_Trial"                                                                                                                                              
[15198] "Clinical_Testing"                                                                                                                                                     
[15199] "Transplantation_and_Immune_System"                                                                                                                                    
[15200] "Conduct_Clinical_Trials"                                                                                                                                              
[15201] "Cancer_Therapy_Evaluation_Program"                                                                                                                                    
[15202] "Detection_of_Minimal_Residual_Disease"                                                                                                                                
[15203] "Developmental_Diagnostic"                                                                                                                                             
[15204] "Diagnostic_Methods_and_Reagents"                                                                                                                                      
[15205] "Diagnostics_Research"                                                                                                                                                 
[15206] "Diagnostics_Cancer"                                                                                                                                                   
[15207] "Drug_Development_Clinical"                                                                                                                                            
[15208] "Drug_Development_Preclinical"                                                                                                                                         
[15209] "Drug_Discovery"                                                                                                                                                       
[15210] "Drug_Discovery_Groups"                                                                                                                                                
[15211] "EPS_Library"                                                                                                                                                          
[15212] "Experimental_Nutrition"                                                                                                                                               
[15213] "Health_and_Behavior_in_Children"                                                                                                                                      
[15214] "High_Dose_Chemotherapy"                                                                                                                                               
[15215] "Intercept_Vertical_Transmission-Perinatal_Transmission_of_HIV"                                                                                                        
[15216] "Laboratory_Animal_Production_and_Facilities"                                                                                                                          
[15217] "Laboratory_Correlate_Data"                                                                                                                                            
[15218] "Low_Dose_Radiation"                                                                                                                                                   
[15219] "Maternal_and_Child_Health"                                                                                                                                            
[15220] "Media_Intervention"                                                                                                                                                   
[15221] "Multicenter_Hemophilia_Cohort_Study"                                                                                                                                  
[15222] "Monitoring_for_Recurrence"                                                                                                                                            
[15223] "Natural_History_of_Progression_of_HIV-related_Diseases"                                                                                                               
[15224] "Neuroscience_and_Neuropsychiatric_Research"                                                                                                                           
[15225] "National_Surgical_Adjuvant_Breast_and_Bowel_Project"                                                                                                                  
[15226] "Nucleic_Acid_Resources"                                                                                                                                               
[15227] "Nutritional_Study"                                                                                                                                                    
[15228] "Nutrition_Research_Applied_Clinical_Trials"                                                                                                                           
[15229] "Nutrition_Research_Applied_Non-Clinical_Trials"                                                                                                                       
[15230] "Nutrition_Research_Basic_Non-Clinical_Trials"                                                                                                                         
[15231] "Nutrition_Dietary_Components"                                                                                                                                         
[15232] "Nutrition_Fats_Saturated"                                                                                                                                             
[15233] "Nutritional_Anthropometry"                                                                                                                                            
[15234] "Nutritional_Biochemistry"                                                                                                                                             
[15235] "Other_Resources"                                                                                                                                                      
[15236] "Outcomes_and_Health_Services_Research"                                                                                                                                
[15237] "Palliative_Other_Than_Pain_and_Hospice"                                                                                                                               
[15238] "Pathobiology_of_Wasting_and_Growth_Retardation"                                                                                                                       
[15239] "Patient_Oriented_Research"                                                                                                                                            
[15240] "Pediatric_Clinic_and_Service"                                                                                                                                         
[15241] "Pharmaceutical_Resources"                                                                                                                                             
[15242] "Phase_I_and_II_Vaccine_Trials"                                                                                                                                        
[15243] "Prostate_Lung_Colorectal_and_Ovarian_Cancer_Screening_Trial"                                                                                                          
[15244] "Population_Intervention"                                                                                                                                              
[15245] "Prevent_Transmission_of_HIV_Safety_Blood_Supply"                                                                                                                      
[15246] "Prevention_and_Treatment_Evaluation"                                                                                                                                  
[15247] "Prevention_and_Treatment_of_Opportunistic_Infection"                                                                                                                  
[15248] "Prevention_of_High-Risk_Behaviors"                                                                                                                                    
[15249] "Prevention_Early_Detection_of_Premalignant_Lesions"                                                                                                                   
[15250] "Preventive_Intervention"                                                                                                                                              
[15251] "Protein_Amino_Acid_Nutrition_Animal"                                                                                                                                  
[15252] "Protein_Amino_Acid_Nutrition_Non-Animal"                                                                                                                              
[15253] "Radiation_Ionizing_Radiotherapy"                                                                                                                                      
[15254] "Radiation_Non-Ionizing_Radiotherapy"                                                                                                                                  
[15255] "Radiology_Treatment_Planning"                                                                                                                                         
[15256] "Radiotherapy_High_Linear_Energy_Transfer"                                                                                                                             
[15257] "Radiotherapy_Low_Linear_Energy_Transfer"                                                                                                                              
[15258] "Redirected_Cytolysis"                                                                                                                                                 
[15259] "Repository_Operations_Other"                                                                                                                                          
[15260] "Repository_Operations_Sera"                                                                                                                                           
[15261] "Social_Health_Services"                                                                                                                                               
[15262] "State_Cancer_Legislative_Database"                                                                                                                                    
[15263] "Clinical_Trials_Therapy"                                                                                                                                              
[15264] "Therapy_Evaluation"                                                                                                                                                   
[15265] "Tissue_Resources"                                                                                                                                                     
[15266] "Trace_Element_Nutrition_Fluorides"                                                                                                                                    
[15267] "Trace_Element_Nutrition_Mercury"                                                                                                                                      
[15268] "Trace_Element_Nutrition_Other"                                                                                                                                        
[15269] "Translational_Research"                                                                                                                                               
[15270] "Tumor_Bank"                                                                                                                                                           
[15271] "Vaccine_Clinical_Trial"                                                                                                                                               
[15272] "Vaccine_Design_and_Animal_Testing"                                                                                                                                    
[15273] "Vaccine_Development_AIDS"                                                                                                                                             
[15274] "Vaccine_Development_Other_Non-AIDS"                                                                                                                                   
[15275] "Vaccine_Related_Development_AIDS"                                                                                                                                     
[15276] "Vaccine_Related_Development_Cancer"                                                                                                                                   
[15277] "Vaccine_Related_Development_Non-Cancer_Non-AIDS"                                                                                                                      
[15278] "Vaccine_Related_Non-Development_AIDS"                                                                                                                                 
[15279] "Vaccine_Related_Non-Development_Non-AIDS"                                                                                                                             
[15280] "Vaccine_Trial-Phase_III_Large_Scale"                                                                                                                                  
[15281] "Validation_of_Clinical_Utility_of_Markers"                                                                                                                            
[15282] "Validation_of_Technology"                                                                                                                                             
[15283] "Virus_Cancer_Research"                                                                                                                                                
[15284] "Worksite_Health_Services"                                                                                                                                             
[15285] "Population_Research"                                                                                                                                                  
[15286] "Infrastructure_Activities"                                                                                                                                            
[15287] "Biology_of_the_Brain_Disorders"                                                                                                                                       
[15288] "New_Approach_to_Pathogenesis"                                                                                                                                         
[15289] "New_Prevention_Strategy_Against_Disease"                                                                                                                              
[15290] "New_Avenue_for_the_Development_of_Therapeutics"                                                                                                                       
[15291] "Computers_and_Advanced_Instrumentation"                                                                                                                               
[15292] "Mind-Body_System"                                                                                                                                                     
[15293] "Mind-Body_Method"                                                                                                                                                     
[15294] "Social_and_Contextual_Areas_of_Mind_Body_Medicine"                                                                                                                    
[15295] "Alternative_Medical_System"                                                                                                                                           
[15296] "Traditional_Indigenous_Systems"                                                                                                                                       
[15297] "Unconventional_Western_System"                                                                                                                                        
[15298] "Social_Aspects_of_Cancer"                                                                                                                                             
[15299] "Evaluation_of_Risk_Factors"                                                                                                                                           
[15300] "Cell_Bank"                                                                                                                                                            
[15301] "Technique_Development"                                                                                                                                                
[15302] "Use_of_New_Techniques"                                                                                                                                                
[15303] "Core_Facility"                                                                                                                                                        
[15304] "Cancer_Causation_Research"                                                                                                                                            
[15305] "Lifestyle_and_Disease_Prevention"                                                                                                                                     
[15306] "Clinical_Preventive_Practices"                                                                                                                                        
[15307] "Lifestyle_Therapy"                                                                                                                                                    
[15308] "Biologically_Based_Therapy"                                                                                                                                           
[15309] "Molecular_Bank"                                                                                                                                                       
[15310] "No_Prior_Therapy"                                                                                                                                                     
[15311] "Prior_Extensive_Radiation"                                                                                                                                            
[15312] "Prior_Limited_Radiation"                                                                                                                                              
[15313] "Pharmacological_Biological_and_Instrumental_Interventions"                                                                                                            
[15314] "Manipulative_and_Body-Based_Methods"                                                                                                                                  
[15315] "Massage_and_Body_Techniques"                                                                                                                                          
[15316] "Unconventional_Physical_Therapies"                                                                                                                                    
[15317] "Biofield_Therapy"                                                                                                                                                     
[15318] "Bioelectromagnetics"                                                                                                                                                  
[15319] "Regional_Chemotherapy"                                                                                                                                                
[15320] "Prophylactic_Cranial_Irradiation"                                                                                                                                     
[15321] "Topical_Chemotherapy"                                                                                                                                                 
[15322] "Tracheoesophageal_Puncture"                                                                                                                                           
[15323] "Central_Nervous_System_Prophylaxis"                                                                                                                                   
[15324] "Arterial_Embolization"                                                                                                                                                
[15325] "Chemical_Immunotherapy"                                                                                                                                               
[15326] "Nutrition_Plant_Components"                                                                                                                                           
[15327] "Nutrition_Protein_Amino_Acids"                                                                                                                                        
[15328] "Vaccine_Related_Non-Development_Total"                                                                                                                                
[15329] "Smoking_and_Health_Research"                                                                                                                                          
[15330] "Cancer_Genome_Anatomy_Project"                                                                                                                                        
[15331] "Definitive_Radiation_Therapy"                                                                                                                                         
[15332] "Nutrition_Alcohol"                                                                                                                                                    
[15333] "Nutrition_Minerals"                                                                                                                                                   
[15334] "Nutrition_Vitamin_B"                                                                                                                                                  
[15335] "Nutrition_Vitamin_C"                                                                                                                                                  
[15336] "Nutrition_Vitamin_E"                                                                                                                                                  
[15337] "Clinical_Management"                                                                                                                                                  
[15338] "Effectiveness_of_Interventions"                                                                                                                                       
[15339] "Health_Research_Service"                                                                                                                                              
[15340] "Risk_Factor_Services"                                                                                                                                                 
[15341] "Surveillance_Modeling"                                                                                                                                                
[15342] "Validity_of_Self_Report"                                                                                                                                              
[15343] "Community_Practice"                                                                                                                                                   
[15344] "Cooperative_Family_Registry"                                                                                                                                          
[15345] "Cancer_Chromosome_Aberration_Project"                                                                                                                                 
[15346] "Genetic_Annotation_Index"                                                                                                                                             
[15347] "Interdisciplinary_Studies_in_the_Genetic_Epidemiology_of_Cancer"                                                                                                      
[15348] "Basic_Behavioral_Studies_in_Cancer-Related_Behaviors"                                                                                                                 
[15349] "Directory_of_Cancer_Genetics_Providers"                                                                                                                               
[15350] "Mouse_Cancer_Genome_Anatomy_Project"                                                                                                                                  
[15351] "Small_Animal_Imaging_Resource_Programs"                                                                                                                               
[15352] "Development_and_Application_of_Imaging_in_Therapeutic_Studies"                                                                                                        
[15353] "Cooperative_Trial_in_Diagnostic_Imaging"                                                                                                                              
[15354] "Development_and_Testing_of_Digital_Mammography_Displays_and_Workstations"                                                                                             
[15355] "Human_Tumor_Gene_Index"                                                                                                                                               
[15356] "Advanced_Technology_Center"                                                                                                                                           
[15357] "Human_Specimen_Resources"                                                                                                                                             
[15358] "Cancer_Control_Research_Program"                                                                                                                                      
[15359] "Cooperative_Family_Registries_for_Breast_and_Colorectal_Cancer_Studies"                                                                                               
[15360] "Genetic_Annotation_Initiative"                                                                                                                                        
[15361] "Heart_Research"                                                                                                                                                       
[15362] "Nucleotide_Analog_Therapeutic"                                                                                                                                        
[15363] "Breast_Cancer_Basic_Research"                                                                                                                                         
[15364] "in_vitro_Assay"                                                                                                                                                       
[15365] "Cellular_Assay"                                                                                                                                                       
[15366] "Blood_Screening"                                                                                                                                                      
[15367] "Rehabilitation_Research"                                                                                                                                              
[15368] "TIL_Research"                                                                                                                                                         
[15369] "Cancer_Control_Research"                                                                                                                                              
[15370] "Neurosciences_Research"                                                                                                                                               
[15371] "Nutrition_Other"                                                                                                                                                      
[15372] "Nutrition_Vitamins_Other"                                                                                                                                             
[15373] "ADME_Study"                                                                                                                                                           
[15374] "Linscott_s_Directory"                                                                                                                                                 
[15375] "NIH_Emphasis_Area"                                                                                                                                                    
[15376] "Genetics_and_Medicine"                                                                                                                                                
[15377] "Cancer_Control"                                                                                                                                                       
[15378] "Biological_Immunotherapy"                                                                                                                                             
[15379] "Immunotoxin_Cancer_Immunotherapy"                                                                                                                                     
[15380] "Biological_Cancer_Immunotherapy"                                                                                                                                      
[15381] "Chemical_Cancer_Immunotherapy"                                                                                                                                        
[15382] "Mouse_Tumor_Gene_Index"                                                                                                                                               
[15383] "Repository_Operations"                                                                                                                                                
[15384] "Repository_Operations_Tissues"                                                                                                                                        
[15385] "Focused_Ultrasound_Therapy"                                                                                                                                           
[15386] "Radiometry_Microwave"                                                                                                                                                 
[15387] "Supportive_Cancer_Chemotherapy"                                                                                                                                       
[15388] "Drug_Development_Experimental"                                                                                                                                        
[15389] "Combined_Pharmacological_Behavioral_Treatment"                                                                                                                        
[15390] "Combined_Prevention_Cessation_Research"                                                                                                                               
[15391] "Nicotine_Dependence_Addiction_on_Treatment"                                                                                                                           
[15392] "Pharmacological_Treatment"                                                                                                                                            
[15393] "Tobacco_Use_and_Related_Risk_Factors_Surveillance"                                                                                                                    
[15394] "Tobacco_Use_Basic_Biological_Research"                                                                                                                                
[15395] "Tobacco_Use_Chemoprevention"                                                                                                                                          
[15396] "Tobacco_Use_Community_and_State_Intervention_Research"                                                                                                                
[15397] "Tobacco_Use_Cessation_Research"                                                                                                                                       
[15398] "Tobacco_Use_Combined_Prevention_Cessation_Research"                                                                                                                   
[15399] "Tobacco_Use_Policy_Research"                                                                                                                                          
[15400] "Basic_Biobehavioral_Research"                                                                                                                                         
[15401] "Behavioral_Biological_Association"                                                                                                                                    
[15402] "Behavioral_Mechanisms"                                                                                                                                                
[15403] "Cessation_Research"                                                                                                                                                   
[15404] "Minimal_Contact_Treatment"                                                                                                                                            
[15405] "Policy_Research"                                                                                                                                                      
[15406] "Health_Services_Delivery_Other"                                                                                                                                       
[15407] "Hospice_Planning_Development"                                                                                                                                         
[15408] "Treatment_of_Infectious_Diseases"                                                                                                                                     
[15409] "Infectious_Diseases_Research"                                                                                                                                         
[15410] "Plasma_Enhancement"                                                                                                                                                   
[15411] "New_Agent"                                                                                                                                                            
[15412] "Vaccine_Design"                                                                                                                                                       
[15413] "Cancer_Information_Service"                                                                                                                                           
[15414] "Cooperative_Group_Program"                                                                                                                                            
[15415] "Developmental_Therapeutics_Program"                                                                                                                                   
[15416] "Scientist_Exchange_Program"                                                                                                                                           
[15417] "Diet_and_Nutrition"                                                                                                                                                   
[15418] "Nutrition_Artificial_Sweeteners"                                                                                                                                      
[15419] "Nutrition_Antioxidants"                                                                                                                                               
[15420] "Nutrition_Caffeine"                                                                                                                                                   
[15421] "Nutrition_Vitamin_A"                                                                                                                                                  
[15422] "Nutrition_Vitamins"                                                                                                                                                   
[15423] "Trace_Element_Nutrition_Selenium"                                                                                                                                     
[15424] "Diet_and_Nutrition_DCP"                                                                                                                                               
[15425] "Diet_and_Nutrition_DCCPS"                                                                                                                                             
[15426] "Breast_Cancer_Prevention_Education_and_Diagnosis_Program_Initiative"                                                                                                  
[15427] "Nutrition_Monitoring"                                                                                                                                                 
[15428] "Antibody-Directed_Enzyme_Prodrug_Therapy"                                                                                                                             
[15429] "Transgenic_Mouse_Facility"                                                                                                                                            
[15430] "Animal_Barrier_Facility"                                                                                                                                              
[15431] "DNA_Sequencing_Facility"                                                                                                                                              
[15432] "Blood_Brain_Barrier_Disruption_Chemotherapy"                                                                                                                          
[15433] "Nucleic_Acid_Core_Facility"                                                                                                                                           
[15434] "Oligonucleotide_Synthesis_Facility"                                                                                                                                   
[15435] "Modest-Temperature_Hyperthermia"                                                                                                                                      
[15436] "Carbogen_Breathing"                                                                                                                                                   
[15437] "Perioperative_Adjuvant_Therapy"                                                                                                                                       
[15438] "Longterm_Follow-up"                                                                                                                                                   
[15439] "Follow-up"                                                                                                                                                            
[15440] "Progenitor_Cell_Engraftment"                                                                                                                                          
[15441] "Three-Dimensional_Conformal_Radiation_Therapy"                                                                                                                        
[15442] "Histopathology_Facility"                                                                                                                                              
[15443] "Organic_Synthesis_Facility"                                                                                                                                           
[15444] "Investigation_of_Mechanisms_of_Drug_Resistance"                                                                                                                       
[15445] "Autologous_Stem_Cell_Transplantation"                                                                                                                                 
[15446] "Immunooncology"                                                                                                                                                       
[15447] "Ancillary_Study"                                                                                                                                                      
[15448] "Limb_Salvage_Procedure"                                                                                                                                               
[15449] "Electron_Microscopy_Facility"                                                                                                                                         
[15450] "Biostatistics_Core"                                                                                                                                                   
[15451] "Food_Patterns"                                                                                                                                                        
[15452] "Diagnostic_Imaging_Program"                                                                                                                                           
[15453] "Community_Oncology_and_Rehabilitation"                                                                                                                                
[15454] "Information_Resources"                                                                                                                                                
[15455] "Radiotherapy_Research"                                                                                                                                                
[15456] "Surveillance_Program"                                                                                                                                                 
[15457] "Toxicity_Attenuation"                                                                                                                                                 
[15458] "Breast_Cancer_Rehabilitation"                                                                                                                                         
[15459] "Cancer_Surveillance_Research"                                                                                                                                         
[15460] "Drug_Synthesis_and_Chemistry"                                                                                                                                         
[15461] "CEPH_Genethon_Map"                                                                                                                                                    
[15462] "Physical_Map_of_the_Human_Genome"                                                                                                                                     
[15463] "Clone-Based_Physical_Map"                                                                                                                                             
[15464] "Recombinant_Interval_Database"                                                                                                                                        
[15465] "Sequence-Ready_Maps"                                                                                                                                                  
[15466] "Single_Nucleotide_Polymorphism_Map"                                                                                                                                   
[15467] "Whitehead_Map_of_the_Human_Genome"                                                                                                                                    
[15468] "Electronic_Tracking_Database"                                                                                                                                         
[15469] "Modeling"                                                                                                                                                             
[15470] "Cancer_Burden"                                                                                                                                                        
[15471] "Cancer_Surveillance_Research_Program"                                                                                                                                 
[15472] "Mortality_Map"                                                                                                                                                        
[15473] "Black_White_Cancer_Survival_Study"                                                                                                                                    
[15474] "Cancer_Surveillance_Project"                                                                                                                                          
[15475] "Breast_Cancer_Prevention_Trial"                                                                                                                                       
[15476] "Prostate_Cancer_Prevention_Trial"                                                                                                                                     
[15477] "Pharmacobehavioral_Research"                                                                                                                                          
[15478] "ASCUS_LSIL_Triage_Study"                                                                                                                                              
[15479] "Marker_Network_for_Bladder_Cancer"                                                                                                                                    
[15480] "Minority-Based_Community_Clinical_Oncology_Program"                                                                                                                   
[15481] "Patient-Focused_Outcomes"                                                                                                                                             
[15482] "Childhood_Cancer_Survivor_Study"                                                                                                                                      
[15483] "Clinical_Trials_Database"                                                                                                                                             
[15484] "Pediatric_Surgical_Procedures"                                                                                                                                        
[15485] "Conventional_Surgery"                                                                                                                                                 
[15486] "Surgical_Management"                                                                                                                                                  
[15487] "Laboratory_Sensitivity"                                                                                                                                               
[15488] "Marker_Discovery"                                                                                                                                                     
[15489] "Prevention_Protocols"                                                                                                                                                 
[15490] "Observational_Study"                                                                                                                                                  
[15491] "Basic_Cancer_Research"                                                                                                                                                
[15492] "Cancer_Intervention"                                                                                                                                                  
[15493] "Animal_Testing"                                                                                                                                                       
[15494] "Extraordinary_Opportunities_for_Investment"                                                                                                                           
[15495] "Extraordinary_Opportunity_Cancer_Genetics"                                                                                                                            
[15496] "Molecular_Classification_of_Tumors-Director_s_Challenge"                                                                                                              
[15497] "Extraordinary_Opportunity_Imaging_Technologies"                                                                                                                       
[15498] "Extraordinary_Opportunity_Preclinical_Models_of_Cancer"                                                                                                               
[15499] "Exogenous_Hormone_Therapy"                                                                                                                                            
[15500] "Cardiac_Function_Study"                                                                                                                                               
[15501] "Clinical_Trials_Cancer_Control"                                                                                                                                       
[15502] "Clinical_Trials_Cancer_Treatment"                                                                                                                                     
[15503] "Community_Clinical_Oncology_Program"                                                                                                                                  
[15504] "Helium-Ion_Radiation"                                                                                                                                                 
[15505] "Cooperative_Breast_Cancer_Tissue_Resource"                                                                                                                            
[15506] "Correlative_Study"                                                                                                                                                    
[15507] "HIV_Drug_Resistance_Program"                                                                                                                                          
[15508] "Investigator-Initiated_Research"                                                                                                                                      
[15509] "Intramural_Research"                                                                                                                                                  
[15510] "Multi-Institutional_Clinical_Trial"                                                                                                                                   
[15511] "Nurses_Health_Study"                                                                                                                                                  
[15512] "Nutrition_Fats_Monosaturated"                                                                                                                                         
[15513] "Non-Invasive_Cancer_Detection"                                                                                                                                        
[15514] "Population-Based_Registry"                                                                                                                                            
[15515] "Preclinical_Testing"                                                                                                                                                  
[15516] "Study_of_Tamoxifen_and_Raloxifene"                                                                                                                                    
[15517] "Nutrition_Fats_Polyunsaturated"                                                                                                                                       
[15518] "Clinical_Trial_Eligibility_Criteria"                                                                                                                                  
[15519] "Psychological_Impact_of_Cancer"                                                                                                                                       
[15520] "Smoking_Prevention"                                                                                                                                                   
[15521] "Suicide_Gene_Therapy"                                                                                                                                                 
[15522] "C51_Cytotoxicity_Assay"                                                                                                                                               
[15523] "Craniospinal_Axis_Irradiation_in_Children"                                                                                                                            
[15524] "Anti-HIV_Therapy"                                                                                                                                                     
[15525] "Antiviral_Therapy"                                                                                                                                                    
[15526] "Abdominal_Surgical_Procedures"                                                                                                                                        
[15527] "Neoplastic_Disease_and_Pregnancy"                                                                                                                                     
[15528] "Biomaterials_Research"                                                                                                                                                
[15529] "Clinical_Trials_Other"                                                                                                                                                
[15530] "Prior_Therapy"                                                                                                                                                        
[15531] "High_Dose_Interferon_Alpha_2a"                                                                                                                                        
[15532] "Population_Database"                                                                                                                                                  
[15533] "Long_Island_Breast_Cancer_Study"                                                                                                                                      
[15534] "Molecular_Target"                                                                                                                                                     
[15535] "Small_Molecule_Chemical_Library"                                                                                                                                      
[15536] "Diversity_Library"                                                                                                                                                    
[15537] "CDC_Behavioral_Risk_Factor_Surveillance_Survey"                                                                                                                       
[15538] "Extraordinary_Opportunity_Genes_and_the_Environment"                                                                                                                  
[15539] "Extraordinary_Opportunity_Cancer_Communications"                                                                                                                      
[15540] "Biobehavioral_Determinants_of_Tobacco_Use_and_Addiction"                                                                                                              
[15541] "Intensity-Modulated_Radiotherapy"                                                                                                                                     
[15542] "Natural_History_and_Cofactors"                                                                                                                                        
[15543] "Special_Populations_Research"                                                                                                                                         
[15544] "Extraordinary_Opportunity_Molecular_Targets_of_Prevention_and_Treatment"                                                                                              
[15545] "Extraordinary_Opportunity_Research_on_Tobacco_and_Tobacco_Related_Cancers"                                                                                            
[15546] "Intervention_Trial"                                                                                                                                                   
[15547] "Pain_Research"                                                                                                                                                        
[15548] "Acupuncture_and_Oriental_Medicine"                                                                                                                                    
[15549] "Repository_of_Specimens_and_Reagents"                                                                                                                                 
[15550] "Combination_Drug_Therapy"                                                                                                                                             
[15551] "Donor_Lymphocyte_Infusion"                                                                                                                                            
[15552] "Public_Health_Applications_Research"                                                                                                                                  
[15553] "Natural_History"                                                                                                                                                      
[15554] "Exclusion_Criteria"                                                                                                                                                   
[15555] "Progesterone_Receptor_Status"                                                                                                                                         
[15556] "Estrogen_Receptor_Status"                                                                                                                                             
[15557] "Menopausal_Status"                                                                                                                                                    
[15558] "Her2_Neu_Status"                                                                                                                                                      
[15559] "Stratification_Factors"                                                                                                                                               
[15560] "Treatment_Step"                                                                                                                                                       
[15561] "Prior_Adjuvant_HDC_ASCT"                                                                                                                                              
[15562] "Prior_Adjuvant_Hormonal_Therapy"                                                                                                                                      
[15563] "Prior_Adjuvant_Immunotherapy"                                                                                                                                         
[15564] "Prior_Adjuvant_Other_Therapy"                                                                                                                                         
[15565] "Number_of_Prior_Chemotherapies"                                                                                                                                       
[15566] "Genetic_Population_Study"                                                                                                                                             
[15567] "Four_A_s_Treatment_Protocol"                                                                                                                                          
[15568] "Nicotine_Nasal_Spray"                                                                                                                                                 
[15569] "Polyp_Prevention_Trial"                                                                                                                                               
[15570] "Low_Fat_High_Fiber_Diet"                                                                                                                                              
[15571] "Highly_Active_Antiretroviral_Therapy"                                                                                                                                 
[15572] "Prostate_Cancer_Outcomes_Study"                                                                                                                                       
[15573] "gp100_Human_Melanoma_Peptide_Vaccine_with_Incomplete_Freunds_Adjuvant"                                                                                                
[15574] "Prior_Immunotherapy"                                                                                                                                                  
[15575] "Prior_Surgery"                                                                                                                                                        
[15576] "Prior_Gene_Therapy"                                                                                                                                                   
[15577] "Prior_Chemotherapy"                                                                                                                                                   
[15578] "Other_Prior_Therapy"                                                                                                                                                  
[15579] "National_Breast_and_Cervical_Cancer_Early_Detection_Program"                                                                                                          
[15580] "Compartmental_Treatment"                                                                                                                                              
[15581] "Prior_Hormone_Therapy"                                                                                                                                                
[15582] "Tobacco_Surveillance"                                                                                                                                                 
[15583] "NCI_Strategic_Plan_to_Reduce_Health_Disparities"                                                                                                                      
[15584] "Center_for_Population_Health"                                                                                                                                         
[15585] "Selenium_and_Vitamin_E_Efficacy_Trial"                                                                                                                                
[15586] "Total_Mesorectal_Excision"                                                                                                                                            
[15587] "Cancer_Biomarkers_Research_Group"                                                                                                                                     
[15588] "Cooperative_Family_Registry_for_Epidemiologic_Studies_of_Colon_Cancer"                                                                                                
[15589] "Telehealth"                                                                                                                                                           
[15590] "Gel_Dosimetry"                                                                                                                                                        
[15591] "Imaging_Guided_Therapy"                                                                                                                                               
[15592] "Orthopedic_Surgical_Procedure"                                                                                                                                        
[15593] "Whole-Brain_Radiotherapy"                                                                                                                                             
[15594] "Transurethral_Electrovaporization_of_the_Prostate"                                                                                                                    
[15595] "Atlas_of_Cancer_Mortality_in_the_United_States"                                                                                                                       
[15596] "Cancer_Care_Outcomes_Research_and_Surveillance_Consortium"                                                                                                            
[15597] "Tissue_Array_Research_Program"                                                                                                                                        
[15598] "Sputum_Cytology"                                                                                                                                                      
[15599] "Genoplasty"                                                                                                                                                           
[15600] "Preoperative_Endocrine_Therapy"                                                                                                                                       
[15601] "AIDS_and_Cancer_Specimen_Bank"                                                                                                                                        
[15602] "Clinical_Trials_Cooperative_Groups_Human_Tissue_Resources"                                                                                                            
[15603] "Intervention"                                                                                                                                                         
[15604] "Protein_Structure_Initiative"                                                                                                                                         
[15605] "Cancer_Research_Project"                                                                                                                                              
[15606] "Stem_Cell_Research"                                                                                                                                                   
[15607] "Hematopoietic_Stem_Cell_Research"                                                                                                                                     
[15608] "Non-Hematopoietic_Stem_Cell_Research"                                                                                                                                 
[15609] "Clinical_or_Research_Activity"                                                                                                                                        
[15610] "MAGE-3-1_PADRE-965-10"                                                                                                                                                
[15611] "Healthcare_Activity"                                                                                                                                                  
[15612] "Energy_Therapy"                                                                                                                                                       
[15613] "Bioelectromagnetic-Based_Therapy"                                                                                                                                     
[15614] "EST_Library"                                                                                                                                                          
[15615] "Early_Detection"                                                                                                                                                      
[15616] "Detection"                                                                                                                                                            
[15617] "Tobacco_Use_Prevention_Research"                                                                                                                                      
[15618] "Cancer_Treatment"                                                                                                                                                     
[15619] "Cancer_Diagnosis"                                                                                                                                                     
[15620] "Mutagenicity_Test"                                                                                                                                                    
[15621] "Soft_Agar_Assay"                                                                                                                                                      
[15622] "Matrigel_Invasion_Assay"                                                                                                                                              
[15623] "Tumor_Formation_in_Athymic_Mice"                                                                                                                                      
[15624] "Nerve-Sparing_Prostatectomy"                                                                                                                                          
[15625] "Seed_Implantation"                                                                                                                                                    
[15626] "ORESTES_Library"                                                                                                                                                      
[15627] "Protein_Replacement_Therapy"                                                                                                                                          
[15628] "Psychological_Impact"                                                                                                                                                 
[15629] "Library"                                                                                                                                                              
[15630] "SAGE_Library"                                                                                                                                                         
[15631] "Nutrition_Vitamin_D"                                                                                                                                                  
[15632] "Health_and_Behavior"                                                                                                                                                  
[15633] "MOP_Photochemotherapy"                                                                                                                                                
[15634] "UVA_Light_Therapy"                                                                                                                                                    
[15635] "Case_Series"                                                                                                                                                          
[15636] "Extensive_Radiation"                                                                                                                                                  
[15637] "Myeloablative_Chemotherapy"                                                                                                                                           
[15638] "Expression_Library"                                                                                                                                                   
[15639] "Nutrition_Macronutrients"                                                                                                                                             
[15640] "Clinical_Sensitivity"                                                                                                                                                 
[15641] "Ames_Assay"                                                                                                                                                           
[15642] "Antisense_Oligonucleotide_Therapy"                                                                                                                                    
[15643] "Validation"                                                                                                                                                           
[15644] "Predictive_Value"                                                                                                                                                     
[15645] "Oncogene_ErbB2"                                                                                                                                                       
[15646] "Oncogene_CSF1R"                                                                                                                                                       
[15647] "Exonuclease"                                                                                                                                                          
[15648] "Five_Prime-Three_Prime_Exonuclease"                                                                                                                                   
[15649] "CRYPTIC_Gene"                                                                                                                                                         
[15650] "Hydroxysteroid-17-Beta_Dehydrogenase-2"                                                                                                                               
[15651] "Acetylation"                                                                                                                                                          
[15652] "Acoustic"                                                                                                                                                             
[15653] "Actin-Binding_Protein"                                                                                                                                                
[15654] "Actin"                                                                                                                                                                
[15655] "Acyltransferase"                                                                                                                                                      
[15656] "Adenine_Phosphoribosyltransferase"                                                                                                                                    
[15657] "Adenosine_Deaminase"                                                                                                                                                  
[15658] "Purinergic-P1_Receptor"                                                                                                                                               
[15659] "ATPase"                                                                                                                                                               
[15660] "Adenylate_Cyclase"                                                                                                                                                    
[15661] "Teenagers"                                                                                                                                                            
[15662] "Adolescents"                                                                                                                                                          
[15663] "Afghanistan"                                                                                                                                                          
[15664] "Elderly"                                                                                                                                                              
[15665] "Aging"                                                                                                                                                                
[15666] "Agriculture"                                                                                                                                                          
[15667] "Albania"                                                                                                                                                              
[15668] "Alcohol_Dehydrogenase"                                                                                                                                                
[15669] "Alcohol_Consumption"                                                                                                                                                  
[15670] "Algeria"                                                                                                                                                              
[15671] "Algorithms"                                                                                                                                                           
[15672] "Alkaline_Phosphatase"                                                                                                                                                 
[15673] "Allele"                                                                                                                                                               
[15674] "Alpha-Fetoprotein"                                                                                                                                                    
[15675] "Alpha_Radiation"                                                                                                                                                      
[15676] "Alternate_Splicing"                                                                                                                                                   
[15677] "Ambulatory_Care_Facility"                                                                                                                                             
[15678] "American_Cancer_Society"                                                                                                                                              
[15679] "Native_American"                                                                                                                                                      
[15680] "Amylase"                                                                                                                                                              
[15681] "Amyloid_Beta-A4_Protein_Precursor"                                                                                                                                    
[15682] "Anaphase"                                                                                                                                                             
[15683] "Anatomical_Sciences"                                                                                                                                                  
[15684] "Comparative_Anatomy"                                                                                                                                                  
[15685] "Andorra"                                                                                                                                                              
[15686] "Angiogram"                                                                                                                                                            
[15687] "Digital_Subtraction_Angiography"                                                                                                                                      
[15688] "Angola"                                                                                                                                                               
[15689] "Animal_Husbandry"                                                                                                                                                     
[15690] "Anthropology"                                                                                                                                                         
[15691] "Antibody"                                                                                                                                                             
[15692] "Anti-Idiotype_Antibody"                                                                                                                                               
[15693] "Avidity"                                                                                                                                                              
[15694] "Antibody-Dependent_Cellular_Cytotoxicity"                                                                                                                             
[15695] "Anticoagulation"                                                                                                                                                      
[15696] "CD4_Antigen"                                                                                                                                                          
[15697] "Differentiation_Antigen"                                                                                                                                              
[15698] "T-Antigen"                                                                                                                                                            
[15699] "Antigua_and_Barbuda"                                                                                                                                                  
[15700] "Architecture"                                                                                                                                                         
[15701] "Argentina"                                                                                                                                                            
[15702] "Armenia"                                                                                                                                                              
[15703] "Aromatase"                                                                                                                                                            
[15704] "Arteriography"                                                                                                                                                        
[15705] "Artificial_Intelligence"                                                                                                                                              
[15706] "Asian_American"                                                                                                                                                       
[15707] "Australia"                                                                                                                                                            
[15708] "Austria"                                                                                                                                                              
[15709] "Autoimmune_Process"                                                                                                                                                   
[15710] "Autoradiography"                                                                                                                                                      
[15711] "Award"                                                                                                                                                                
[15712] "Azerbaijan"                                                                                                                                                           
[15713] "B16_Malignant_Melanoma"                                                                                                                                               
[15714] "Low-Level_Radiation"                                                                                                                                                  
[15715] "Bacterial_Protein"                                                                                                                                                    
[15716] "Bacteriology"                                                                                                                                                         
[15717] "Bahamas"                                                                                                                                                              
[15718] "Bahrain"                                                                                                                                                              
[15719] "Bangladesh"                                                                                                                                                           
[15720] "Barbados"                                                                                                                                                             
[15721] "BCR-ABL_Oncoprotein"                                                                                                                                                  
[15722] "Behavior"                                                                                                                                                             
[15723] "Behavioral_Medicine"                                                                                                                                                  
[15724] "Behavioral_Sciences"                                                                                                                                                  
[15725] "Belgium"                                                                                                                                                              
[15726] "Belief_System"                                                                                                                                                        
[15727] "Belize"                                                                                                                                                               
[15728] "Benin_Republic"                                                                                                                                                       
[15729] "Bermuda"                                                                                                                                                              
[15730] "Beta_Globulin"                                                                                                                                                        
[15731] "Bhutan"                                                                                                                                                               
[15732] "Biochemistry"                                                                                                                                                         
[15733] "Biomaterials"                                                                                                                                                         
[15734] "Bioelectric_Energy_Sources"                                                                                                                                           
[15735] "Biomedical_Ethics"                                                                                                                                                    
[15736] "Bioassay"                                                                                                                                                             
[15737] "Biomarker"                                                                                                                                                            
[15738] "Psychobiology"                                                                                                                                                        
[15739] "Biological_Sciences"                                                                                                                                                  
[15740] "Biology"                                                                                                                                                              
[15741] "Biomechanics"                                                                                                                                                         
[15742] "Biostatistics"                                                                                                                                                        
[15743] "Biological_Rhythm"                                                                                                                                                    
[15744] "Biophysics"                                                                                                                                                           
[15745] "Biosensors"                                                                                                                                                           
[15746] "Biotechnology"                                                                                                                                                        
[15747] "African_American"                                                                                                                                                     
[15748] "Blood_Circulation"                                                                                                                                                    
[15749] "Coagulation_Factor"                                                                                                                                                   
[15750] "Northern_Blotting"                                                                                                                                                    
[15751] "Blotting_Southern"                                                                                                                                                    
[15752] "Blotting_Western"                                                                                                                                                     
[15753] "Body_Mass_Index"                                                                                                                                                      
[15754] "Bolivia"                                                                                                                                                              
[15755] "Book"                                                                                                                                                                 
[15756] "Bosnia-Herzegovina"                                                                                                                                                   
[15757] "Botany"                                                                                                                                                               
[15758] "Botswana"                                                                                                                                                             
[15759] "Brazil"                                                                                                                                                               
[15760] "British_Indian_Ocean_Territory"                                                                                                                                       
[15761] "Bronchoscopy"                                                                                                                                                         
[15762] "Brunei"                                                                                                                                                               
[15763] "Bulgaria"                                                                                                                                                             
[15764] "Burkina_Faso"                                                                                                                                                         
[15765] "Myanmar"                                                                                                                                                              
[15766] "Burundi"                                                                                                                                                              
[15767] "Belarus"                                                                                                                                                              
[15768] "Cadherin"                                                                                                                                                             
[15769] "Calcium_Channel"                                                                                                                                                      
[15770] "Calmodulin"                                                                                                                                                           
[15771] "Mitogen-Activated_Protein_Kinase"                                                                                                                                     
[15772] "Calpain"                                                                                                                                                              
[15773] "Cambodia"                                                                                                                                                             
[15774] "Cameroon"                                                                                                                                                             
[15775] "Canada"                                                                                                                                                               
[15776] "Canton_and_Enderbury_Islands"                                                                                                                                         
[15777] "Cape_Verde"                                                                                                                                                           
[15778] "Capsid_Protein"                                                                                                                                                       
[15779] "CD66E_Antigen"                                                                                                                                                        
[15780] "Cardiovascular_Physiology"                                                                                                                                            
[15781] "Transport_Protein"                                                                                                                                                    
[15782] "Catechol-O-Methyltransferase"                                                                                                                                         
[15783] "Cathepsin-D"                                                                                                                                                          
[15784] "Cathepsin"                                                                                                                                                            
[15785] "Etiology"                                                                                                                                                             
[15786] "Cayman_Islands"                                                                                                                                                       
[15787] "Cell_Adhesion"                                                                                                                                                        
[15788] "Cell_Adhesion_Molecule"                                                                                                                                               
[15789] "Cell_Aging"                                                                                                                                                           
[15790] "Intercellular_Communication"                                                                                                                                          
[15791] "Cell_Culture"                                                                                                                                                         
[15792] "Cell_Cycle"                                                                                                                                                           
[15793] "Cell_Death"                                                                                                                                                           
[15794] "Cell_Differentiation"                                                                                                                                                 
[15795] "Cell_Division"                                                                                                                                                        
[15796] "Cell_Fusion"                                                                                                                                                          
[15797] "Cell_Growth"                                                                                                                                                          
[15798] "Cell_Line"                                                                                                                                                            
[15799] "Cell_Motility"                                                                                                                                                        
[15800] "Cell_Physiology"                                                                                                                                                      
[15801] "Cell_Sorting"                                                                                                                                                         
[15802] "Cell_Survival"                                                                                                                                                        
[15803] "Centers_for_Disease_Control_and_Prevention"                                                                                                                           
[15804] "Central_African_Republic"                                                                                                                                             
[15805] "Centrifugation"                                                                                                                                                       
[15806] "Density_Gradient_Centrifugation"                                                                                                                                      
[15807] "Chad"                                                                                                                                                                 
[15808] "Chemical_Engineering"                                                                                                                                                 
[15809] "Chemistry"                                                                                                                                                            
[15810] "Analytical_Chemistry"                                                                                                                                                 
[15811] "Bioinorganic_Chemistry"                                                                                                                                               
[15812] "Clinical_Chemistry"                                                                                                                                                   
[15813] "Inorganic_Chemistry"                                                                                                                                                  
[15814] "Organic_Chemistry"                                                                                                                                                    
[15815] "Medicinal_Chemistry"                                                                                                                                                  
[15816] "Physical_Chemistry"                                                                                                                                                   
[15817] "Chemotaxis"                                                                                                                                                           
[15818] "Children"                                                                                                                                                             
[15819] "Child_Abuse_and_Neglect"                                                                                                                                              
[15820] "Child_Psychiatry"                                                                                                                                                     
[15821] "Developmental_Psychology_Child"                                                                                                                                       
[15822] "Chile"                                                                                                                                                                
[15823] "China"                                                                                                                                                                
[15824] "Chloramphenicol-O-Acetyltransferase"                                                                                                                                  
[15825] "Endoscopic_Retrograde_Cholangiopancreatography"                                                                                                                       
[15826] "Chromatography"                                                                                                                                                       
[15827] "Affinity_Chromatography"                                                                                                                                              
[15828] "Gel_Filtration_Chromatography"                                                                                                                                        
[15829] "High_Performance-Liquid_Chromatography"                                                                                                                               
[15830] "Liquid_Chromatography"                                                                                                                                                
[15831] "Chromogranin"                                                                                                                                                         
[15832] "Chromosome_Banding"                                                                                                                                                   
[15833] "Gene_Mapping"                                                                                                                                                         
[15834] "Clinical_Informatics"                                                                                                                                                 
[15835] "Clinical_Medicine"                                                                                                                                                    
[15836] "Cell_Clone"                                                                                                                                                           
[15837] "Cloning"                                                                                                                                                              
[15838] "Gene_Cloning"                                                                                                                                                         
[15839] "Cloudman_S91_Malignant_Melanoma"                                                                                                                                      
[15840] "Cocos_Keeling_Islands"                                                                                                                                                
[15841] "Cognition"                                                                                                                                                            
[15842] "Collagen"                                                                                                                                                             
[15843] "Collagen-IV"                                                                                                                                                          
[15844] "Colombia"                                                                                                                                                             
[15845] "Colonoscopy"                                                                                                                                                          
[15846] "Colposcopy"                                                                                                                                                           
[15847] "Communication"                                                                                                                                                        
[15848] "Community"                                                                                                                                                            
[15849] "Community_Health_Center"                                                                                                                                              
[15850] "Community_Health_Education"                                                                                                                                           
[15851] "Community_Health_Nursing"                                                                                                                                             
[15852] "Comorbidity"                                                                                                                                                          
[15853] "Comoros"                                                                                                                                                              
[15854] "Complement"                                                                                                                                                           
[15855] "Computer_Graphics"                                                                                                                                                    
[15856] "Computer_Modeling"                                                                                                                                                    
[15857] "Computer_System"                                                                                                                                                      
[15858] "Computer_Systems_Development"                                                                                                                                         
[15859] "Computers"                                                                                                                                                            
[15860] "Conception"                                                                                                                                                           
[15861] "Confidentiality"                                                                                                                                                      
[15862] "Congo"                                                                                                                                                                
[15863] "Consent_Form"                                                                                                                                                         
[15864] "Cook_Islands"                                                                                                                                                         
[15865] "Costa_Rica"                                                                                                                                                           
[15866] "Costs"                                                                                                                                                                
[15867] "Cost_Benefit_Analysis"                                                                                                                                                
[15868] "Creatine_Kinase"                                                                                                                                                      
[15869] "Croatia"                                                                                                                                                              
[15870] "Cryopreservation"                                                                                                                                                     
[15871] "Crystallography"                                                                                                                                                      
[15872] "Cuba"                                                                                                                                                                 
[15873] "Culture"                                                                                                                                                              
[15874] "Protein_Kinase-A"                                                                                                                                                     
[15875] "Cyprus"                                                                                                                                                               
[15876] "Cysteine_Proteinase"                                                                                                                                                  
[15877] "Cystoscopy"                                                                                                                                                           
[15878] "Cytochemistry"                                                                                                                                                        
[15879] "Cytochrome-P450"                                                                                                                                                      
[15880] "Cytochrome-P450-2E1"                                                                                                                                                  
[15881] "Cytochrome"                                                                                                                                                           
[15882] "Cytogenetics"                                                                                                                                                         
[15883] "Cytokeratin-19"                                                                                                                                                       
[15884] "Cytokinesis"                                                                                                                                                          
[15885] "Cytological_Techniques"                                                                                                                                               
[15886] "Cytology"                                                                                                                                                             
[15887] "Cytoskeletal_Protein"                                                                                                                                                 
[15888] "Data_Sources"                                                                                                                                                         
[15889] "Demographics"                                                                                                                                                         
[15890] "Denmark"                                                                                                                                                              
[15891] "Dentistry"                                                                                                                                                            
[15892] "Deoxycytidine_Kinase"                                                                                                                                                 
[15893] "Deoxyribonuclease"                                                                                                                                                    
[15894] "Dermatology"                                                                                                                                                          
[15895] "Developmental_Biology"                                                                                                                                                
[15896] "Diagnostic_Imaging"                                                                                                                                                   
[15897] "Digestion"                                                                                                                                                            
[15898] "Animal_Model"                                                                                                                                                         
[15899] "Susceptibility"                                                                                                                                                       
[15900] "Djibouti"                                                                                                                                                             
[15901] "DNA_Damage"                                                                                                                                                           
[15902] "DNA_Modification_Methylase"                                                                                                                                           
[15903] "Terminal_Deoxyribonucleotidyl_Transferase"                                                                                                                            
[15904] "DNA_Polymerase_Alpha"                                                                                                                                                 
[15905] "DNA_Polymerase_Delta"                                                                                                                                                 
[15906] "DNA-Directed_DNA_Polymerase"                                                                                                                                          
[15907] "DNA_Repair"                                                                                                                                                           
[15908] "DNA_Replication"                                                                                                                                                      
[15909] "Restriction_Endonuclease"                                                                                                                                             
[15910] "Topoisomerase-I"                                                                                                                                                      
[15911] "DNA_Helicase"                                                                                                                                                         
[15912] "DNA_Binding_Protein"                                                                                                                                                  
[15913] "Dominica"                                                                                                                                                             
[15914] "Dominican_Republic"                                                                                                                                                   
[15915] "Transcriptional_Repression"                                                                                                                                           
[15916] "Drug_Abuse"                                                                                                                                                           
[15917] "Drug_Resistance"                                                                                                                                                      
[15918] "Echocardiography"                                                                                                                                                     
[15919] "Ecology"                                                                                                                                                              
[15920] "Medical_Economics"                                                                                                                                                    
[15921] "Ecuador"                                                                                                                                                              
[15922] "Education"                                                                                                                                                            
[15923] "Egypt"                                                                                                                                                                
[15924] "Ejaculation"                                                                                                                                                          
[15925] "El_Salvador"                                                                                                                                                          
[15926] "Electromagnetic_Fields"                                                                                                                                               
[15927] "Electron_Spin_Resonance_Spectroscopy"                                                                                                                                 
[15928] "Beta_Radiation"                                                                                                                                                       
[15929] "Electrophoresis"                                                                                                                                                      
[15930] "Agarose_Gel_Electrophoresis"                                                                                                                                          
[15931] "_2-D_Gel_Electrophoresis"                                                                                                                                             
[15932] "Polyacrylamide_Gel_Electrophoresis"                                                                                                                                   
[15933] "Electrophysiology"                                                                                                                                                    
[15934] "Embryo_Transfer"                                                                                                                                                      
[15935] "Embryology"                                                                                                                                                           
[15936] "Endocrinology"                                                                                                                                                        
[15937] "Endocytosis"                                                                                                                                                          
[15938] "Endoscope"                                                                                                                                                            
[15939] "Endoscopy"                                                                                                                                                            
[15940] "Energy_Metabolism"                                                                                                                                                    
[15941] "Engineering"                                                                                                                                                          
[15942] "Engineering_Psychology"                                                                                                                                               
[15943] "Entomology"                                                                                                                                                           
[15944] "Environment"                                                                                                                                                          
[15945] "Environmental_Exposure"                                                                                                                                               
[15946] "ELISA"                                                                                                                                                                
[15947] "Enzyme"                                                                                                                                                               
[15948] "Epidemiological_Methods"                                                                                                                                              
[15949] "Epidemiology"                                                                                                                                                         
[15950] "Equatorial_Guinea"                                                                                                                                                    
[15951] "Eritrea"                                                                                                                                                              
[15952] "Erythropoiesis"                                                                                                                                                       
[15953] "Esophagoscopy"                                                                                                                                                        
[15954] "Esterase"                                                                                                                                                             
[15955] "Estonia"                                                                                                                                                              
[15956] "Ethiopia"                                                                                                                                                             
[15957] "Ethnic_Group"                                                                                                                                                         
[15958] "Evolution"                                                                                                                                                            
[15959] "Excision_Repair"                                                                                                                                                      
[15960] "Exercise"                                                                                                                                                             
[15961] "Exocytosis"                                                                                                                                                           
[15962] "DNA_Exonuclease"                                                                                                                                                      
[15963] "Coagulation_Factor-VII"                                                                                                                                               
[15964] "Coagulation_Factor-VIII"                                                                                                                                              
[15965] "von_Willebrand_Factor"                                                                                                                                                
[15966] "Faroe_Islands"                                                                                                                                                        
[15967] "Fatty_Acid_Synthase"                                                                                                                                                  
[15968] "Ingestive_Behavior"                                                                                                                                                   
[15969] "Female"                                                                                                                                                               
[15970] "Ferritin"                                                                                                                                                             
[15971] "Fertility"                                                                                                                                                            
[15972] "Fertilization"                                                                                                                                                        
[15973] "in_vitro_Fertilization"                                                                                                                                               
[15974] "Fibronectin"                                                                                                                                                          
[15975] "Fiji"                                                                                                                                                                 
[15976] "Filtration"                                                                                                                                                           
[15977] "Finland"                                                                                                                                                              
[15978] "Flow_Cytometry"                                                                                                                                                       
[15979] "Fluorescence"                                                                                                                                                         
[15980] "Fluorophotometry"                                                                                                                                                     
[15981] "Fluoroscopy"                                                                                                                                                          
[15982] "Food_Microbiology"                                                                                                                                                    
[15983] "Food_Industry"                                                                                                                                                        
[15984] "Forensic_Medicine"                                                                                                                                                    
[15985] "France"                                                                                                                                                               
[15986] "French_Guiana"                                                                                                                                                        
[15987] "French_Polynesia"                                                                                                                                                     
[15988] "Fucosyltransferase"                                                                                                                                                   
[15989] "Gabon"                                                                                                                                                                
[15990] "Galactosyltransferase"                                                                                                                                                
[15991] "Gambia"                                                                                                                                                               
[15992] "Gametogenesis"                                                                                                                                                        
[15993] "Gamma_Camera"                                                                                                                                                         
[15994] "Gamma_Globulin"                                                                                                                                                       
[15995] "Gamma-Glutamylcysteine_Synthetase"                                                                                                                                    
[15996] "Gastroenterology"                                                                                                                                                     
[15997] "Gastroscopy"                                                                                                                                                          
[15998] "Gene_Amplification"                                                                                                                                                   
[15999] "Gene_Deletion"                                                                                                                                                        
[16000] "Gene_Duplication"                                                                                                                                                     
[16001] "Gene_Expression"                                                                                                                                                      
[16002] "Regulation_of_Gene_Expression"                                                                                                                                        
[16003] "ENV_Protein"                                                                                                                                                          
[16004] "Gene_Rearrangement"                                                                                                                                                   
[16005] "Gene"                                                                                                                                                                 
[16006] "ENV"                                                                                                                                                                  
[16007] "GAG_Gene"                                                                                                                                                             
[16008] "Homeobox_Gene"                                                                                                                                                        
[16009] "MHC_Class-II_Gene"                                                                                                                                                    
[16010] "MHC_Class-I_Gene"                                                                                                                                                     
[16011] "POL_Gene"                                                                                                                                                             
[16012] "TAT_Gene"                                                                                                                                                             
[16013] "Viral_Gene"                                                                                                                                                           
[16014] "Genetic_Engineering"                                                                                                                                                  
[16015] "Genetic_Marker"                                                                                                                                                       
[16016] "Genetic_Techniques"                                                                                                                                                   
[16017] "Genetics"                                                                                                                                                             
[16018] "Behavioral_Genetics"                                                                                                                                                  
[16019] "Biochemical_Genetics"                                                                                                                                                 
[16020] "Medical_Genetics"                                                                                                                                                     
[16021] "Population_Genetics"                                                                                                                                                  
[16022] "Genome"                                                                                                                                                               
[16023] "Human_Genome"                                                                                                                                                         
[16024] "Genotype"                                                                                                                                                             
[16025] "Geographic_Area"                                                                                                                                                      
[16026] "Geography"                                                                                                                                                            
[16027] "Georgia"                                                                                                                                                              
[16028] "Geriatrics"                                                                                                                                                           
[16029] "Germany"                                                                                                                                                              
[16030] "Gold_Coast"                                                                                                                                                           
[16031] "Gibraltar"                                                                                                                                                            
[16032] "Kiribati"                                                                                                                                                             
[16033] "Glucose-6-Phosphate_Dehydrogenase"                                                                                                                                    
[16034] "Glutathione_S-Transferase"                                                                                                                                            
[16035] "Glycoprotein"                                                                                                                                                         
[16036] "Protein_Glycosylation"                                                                                                                                                
[16037] "Grants"                                                                                                                                                               
[16038] "Greece"                                                                                                                                                               
[16039] "Greenland"                                                                                                                                                            
[16040] "Grenada"                                                                                                                                                              
[16041] "Tissue_Growth"                                                                                                                                                        
[16042] "Embryogenesis"                                                                                                                                                        
[16043] "GTPase"                                                                                                                                                               
[16044] "Guadeloupe"                                                                                                                                                           
[16045] "Guam"                                                                                                                                                                 
[16046] "Guanylate_Cyclase"                                                                                                                                                    
[16047] "Guatemala"                                                                                                                                                            
[16048] "Guinea"                                                                                                                                                               
[16049] "Guinea-Bissau"                                                                                                                                                        
[16050] "Guyana"                                                                                                                                                               
[16051] "Gynecology"                                                                                                                                                           
[16052] "Oncogene_H-Ras"                                                                                                                                                       
[16053] "Haiti"                                                                                                                                                                
[16054] "Disabled_Population"                                                                                                                                                  
[16055] "Harding-Passey_Malignant_Melanoma"                                                                                                                                    
[16056] "Health_Behavior"                                                                                                                                                      
[16057] "Health_Education"                                                                                                                                                     
[16058] "Medicare"                                                                                                                                                             
[16059] "Health_Care_Provider"                                                                                                                                                 
[16060] "Health_Physics"                                                                                                                                                       
[16061] "Health_Policy"                                                                                                                                                        
[16062] "Health_Status"                                                                                                                                                        
[16063] "Hearing"                                                                                                                                                              
[16064] "Heat_Shock_27kD_Protein-1"                                                                                                                                            
[16065] "Heat_Shock_Protein"                                                                                                                                                   
[16066] "Hematology"                                                                                                                                                           
[16067] "Hematopoiesis"                                                                                                                                                        
[16068] "Heme_Protein"                                                                                                                                                         
[16069] "Hemoglobin"                                                                                                                                                           
[16070] "Canonical_HMG_Protein"                                                                                                                                                
[16071] "Histocompatibility_Antigen_Class_I"                                                                                                                                   
[16072] "Histocompatibility_Antigen_Class_II"                                                                                                                                  
[16073] "Histological_Techniques"                                                                                                                                              
[16074] "Histology"                                                                                                                                                            
[16075] "Histone_Deacetylase"                                                                                                                                                  
[16076] "Histone-H1"                                                                                                                                                           
[16077] "Histone-H2A"                                                                                                                                                          
[16078] "Histone-H3"                                                                                                                                                           
[16079] "Histone-H4"                                                                                                                                                           
[16080] "Histone"                                                                                                                                                              
[16081] "HIV_Antibody"                                                                                                                                                         
[16082] "HIV_Envelope_Protein-gp120"                                                                                                                                           
[16083] "HIV_Envelope_Protein-gp41"                                                                                                                                            
[16084] "HLA-A2_Antigen"                                                                                                                                                       
[16085] "HLA-DR_Antigen"                                                                                                                                                       
[16086] "HMGN2_Protein"                                                                                                                                                        
[16087] "Honduras"                                                                                                                                                             
[16088] "Hong_Kong"                                                                                                                                                            
[16089] "Hospital"                                                                                                                                                             
[16090] "Host-Parasite_Relationship"                                                                                                                                           
[16091] "Human_Genetics"                                                                                                                                                       
[16092] "Hungary"                                                                                                                                                              
[16093] "Hybridoma"                                                                                                                                                            
[16094] "Hydrolase"                                                                                                                                                            
[16095] "Hydrolysis"                                                                                                                                                           
[16096] "Hypoxanthine_Phosphoribosyltransferase"                                                                                                                               
[16097] "Iceland"                                                                                                                                                              
[16098] "Immunity"                                                                                                                                                             
[16099] "Cell-Mediated_Immunity"                                                                                                                                               
[16100] "Humoral_Immunity"                                                                                                                                                     
[16101] "Immunochemistry"                                                                                                                                                      
[16102] "Immunoenzyme_Techniques"                                                                                                                                              
[16103] "Immunogenetics"                                                                                                                                                       
[16104] "Idiotype"                                                                                                                                                             
[16105] "Immunoglobulin_Heavy_Chain"                                                                                                                                           
[16106] "Immunoglobulin_Light_Chain_Kappa"                                                                                                                                     
[16107] "Immunoglobulin_Light_Chain_Lambda"                                                                                                                                    
[16108] "Immunoglobulin_Light_Chain"                                                                                                                                           
[16109] "Immunohistochemistry"                                                                                                                                                 
[16110] "Immunologic_Techniques"                                                                                                                                               
[16111] "Immunoprecipitation"                                                                                                                                                  
[16112] "Immunoprotein"                                                                                                                                                        
[16113] "Incidence"                                                                                                                                                            
[16114] "India"                                                                                                                                                                
[16115] "Indonesia"                                                                                                                                                            
[16116] "Infant_Mortality"                                                                                                                                                     
[16117] "Developmental_Psychology_Infant"                                                                                                                                      
[16118] "Newborn"                                                                                                                                                              
[16119] "Information_Dissemination"                                                                                                                                            
[16120] "Information_Sciences"                                                                                                                                                 
[16121] "Information_Storage_and_Retrieval"                                                                                                                                    
[16122] "Informed_Consent"                                                                                                                                                     
[16123] "Infrared_Radiation"                                                                                                                                                   
[16124] "Implantable_Pump"                                                                                                                                                     
[16125] "Inhaler"                                                                                                                                                              
[16126] "Artificial_Insemination"                                                                                                                                              
[16127] "Institute_of_Medicine"                                                                                                                                                
[16128] "Institutional_Review_Board"                                                                                                                                           
[16129] "Instrumentation"                                                                                                                                                      
[16130] "Insulin-Like_Growth_Factor-1"                                                                                                                                         
[16131] "Insulin-Like_Growth_Factor-2"                                                                                                                                         
[16132] "Insurance"                                                                                                                                                            
[16133] "Insurance_Health_Reimbursement"                                                                                                                                       
[16134] "Transmembrane_Protein"                                                                                                                                                
[16135] "Integrin"                                                                                                                                                             
[16136] "Internal_Medicine"                                                                                                                                                    
[16137] "Interphase"                                                                                                                                                           
[16138] "Interview"                                                                                                                                                            
[16139] "Thyroid_Peroxidase"                                                                                                                                                   
[16140] "Gated_Ion_Channel"                                                                                                                                                    
[16141] "Ion_Channel"                                                                                                                                                          
[16142] "Iran"                                                                                                                                                                 
[16143] "Iraq"                                                                                                                                                                 
[16144] "Ireland"                                                                                                                                                              
[16145] "Isoelectric_Focusing"                                                                                                                                                 
[16146] "Isomerase"                                                                                                                                                            
[16147] "Israel"                                                                                                                                                               
[16148] "Italy"                                                                                                                                                                
[16149] "Cote_dIvoire"                                                                                                                                                         
[16150] "Jamaica"                                                                                                                                                              
[16151] "Japan"                                                                                                                                                                
[16152] "Jordan"                                                                                                                                                               
[16153] "Oncogene_K-Ras"                                                                                                                                                       
[16154] "Kallikrein"                                                                                                                                                           
[16155] "Karyotyping"                                                                                                                                                          
[16156] "Kenya"                                                                                                                                                                
[16157] "Kinetics"                                                                                                                                                             
[16158] "Kyrgyzstan"                                                                                                                                                           
[16159] "Knowledge_Attitudes_Behaviors"                                                                                                                                        
[16160] "North_Korea"                                                                                                                                                          
[16161] "South_Korea"                                                                                                                                                          
[16162] "Kuwait"                                                                                                                                                               
[16163] "Laboratory_Animal_Science"                                                                                                                                            
[16164] "LacZ_Gene"                                                                                                                                                            
[16165] "Laminin"                                                                                                                                                              
[16166] "Language"                                                                                                                                                             
[16167] "Lao_Peoples_Democratic_Republic"                                                                                                                                      
[16168] "Laryngoscopy"                                                                                                                                                         
[16169] "Laser"                                                                                                                                                                
[16170] "Latvia"                                                                                                                                                               
[16171] "Lebanon"                                                                                                                                                              
[16172] "Lectin"                                                                                                                                                               
[16173] "Law"                                                                                                                                                                  
[16174] "Lesotho"                                                                                                                                                              
[16175] "LD-50"                                                                                                                                                                
[16176] "Integrin_Alpha-X"                                                                                                                                                     
[16177] "Mixed_Lymphocyte_Reaction_Test"                                                                                                                                       
[16178] "Liberia"                                                                                                                                                              
[16179] "Library_Science"                                                                                                                                                      
[16180] "Libyan_Arab_Jamahiriya"                                                                                                                                               
[16181] "Liechtenstein"                                                                                                                                                        
[16182] "Lifestyle"                                                                                                                                                            
[16183] "Ligase"                                                                                                                                                               
[16184] "Genetic_Linkage_Analysis"                                                                                                                                             
[16185] "Linkage_Disequilibrium"                                                                                                                                               
[16186] "Lithuania"                                                                                                                                                            
[16187] "LOD_Score"                                                                                                                                                            
[16188] "Long-Term_Care_for_Elderly"                                                                                                                                           
[16189] "Luciferase"                                                                                                                                                           
[16190] "Luxembourg"                                                                                                                                                           
[16191] "Lyase"                                                                                                                                                                
[16192] "Lymphangiogram"                                                                                                                                                       
[16193] "Lymphography"                                                                                                                                                         
[16194] "Macau"                                                                                                                                                                
[16195] "Madagascar"                                                                                                                                                           
[16196] "Magnetic_Resonance_Imaging"                                                                                                                                           
[16197] "Magnetic_Resonance_Spectroscopy"                                                                                                                                      
[16198] "Magnetoencephalography"                                                                                                                                               
[16199] "Major_Histocompatibility_Complex_Gene"                                                                                                                                
[16200] "Malawi"                                                                                                                                                               
[16201] "Malaysia"                                                                                                                                                             
[16202] "Maldives"                                                                                                                                                             
[16203] "Mali"                                                                                                                                                                 
[16204] "Malta"                                                                                                                                                                
[16205] "Mammography"                                                                                                                                                          
[16206] "Manganese_Superoxide_Dismutase"                                                                                                                                       
[16207] "Manometry"                                                                                                                                                            
[16208] "Marine_Biology"                                                                                                                                                       
[16209] "Marshall_Islands"                                                                                                                                                     
[16210] "Martinique"                                                                                                                                                           
[16211] "Maternal_Physiology"                                                                                                                                                  
[16212] "Mathematics"                                                                                                                                                          
[16213] "Mauritania"                                                                                                                                                           
[16214] "Mauritius"                                                                                                                                                            
[16215] "Mayotte"                                                                                                                                                              
[16216] "Mediastinoscopy"                                                                                                                                                      
[16217] "Medical_Device"                                                                                                                                                       
[16218] "Medical_Imaging"                                                                                                                                                      
[16219] "Medical_Oncology"                                                                                                                                                     
[16220] "Medicine"                                                                                                                                                             
[16221] "Meiosis"                                                                                                                                                              
[16222] "Experimental_Malignant_Melanoma"                                                                                                                                      
[16223] "Membrane_Metalloendopeptidase"                                                                                                                                        
[16224] "Membrane_Protein"                                                                                                                                                     
[16225] "Menstrual_Cycle"                                                                                                                                                      
[16226] "Psychological_Health"                                                                                                                                                 
[16227] "Mental_Process"                                                                                                                                                       
[16228] "Detoxification"                                                                                                                                                       
[16229] "Metabolism_Organismal"                                                                                                                                                
[16230] "Metalloproteinase"                                                                                                                                                    
[16231] "Metalloprotein"                                                                                                                                                       
[16232] "Metallothionein"                                                                                                                                                      
[16233] "Metaphase"                                                                                                                                                            
[16234] "Techniques"                                                                                                                                                           
[16235] "Methylation"                                                                                                                                                          
[16236] "Methyltransferase"                                                                                                                                                    
[16237] "Mexico"                                                                                                                                                               
[16238] "Microbiology"                                                                                                                                                         
[16239] "Microfilament_Protein"                                                                                                                                                
[16240] "Microscopy"                                                                                                                                                           
[16241] "Electron_Microscopy"                                                                                                                                                  
[16242] "Scanning_Electron_Microscopy"                                                                                                                                         
[16243] "Fluorescence_Microscopy"                                                                                                                                              
[16244] "Phase-Contrast_Microscopy"                                                                                                                                            
[16245] "Polarization_Microscopy"                                                                                                                                              
[16246] "Ultraviolet_Microscopy"                                                                                                                                               
[16247] "Microsomal_Epoxide_Hydrolase"                                                                                                                                         
[16248] "Microtubule_Associated_Protein"                                                                                                                                       
[16249] "Microwave_Radiation"                                                                                                                                                  
[16250] "Minority_Group"                                                                                                                                                       
[16251] "Mitosis"                                                                                                                                                              
[16252] "Mixed_Function_Oxidase"                                                                                                                                               
[16253] "Model_System"                                                                                                                                                         
[16254] "Molecular_Model"                                                                                                                                                      
[16255] "Neurological_Model"                                                                                                                                                   
[16256] "Statistical_Modeling"                                                                                                                                                 
[16257] "Mathematical_Model"                                                                                                                                                   
[16258] "Moldova"                                                                                                                                                              
[16259] "Molecular_Biology"                                                                                                                                                    
[16260] "Molecular_Neurobiology"                                                                                                                                               
[16261] "Monaco"                                                                                                                                                               
[16262] "Mongolia"                                                                                                                                                             
[16263] "Montserrat"                                                                                                                                                           
[16264] "Morbidity"                                                                                                                                                            
[16265] "Morocco"                                                                                                                                                              
[16266] "Morphogenesis"                                                                                                                                                        
[16267] "Mortality"                                                                                                                                                            
[16268] "MOS_Gene"                                                                                                                                                             
[16269] "Mozambique"                                                                                                                                                           
[16270] "Mucin"                                                                                                                                                                
[16271] "Muscle_Protein"                                                                                                                                                       
[16272] "Mutation"                                                                                                                                                             
[16273] "Oncogene_MYB"                                                                                                                                                         
[16274] "MYC_Gene"                                                                                                                                                             
[16275] "Myelogram"                                                                                                                                                            
[16276] "Oncogene_N-RAS"                                                                                                                                                       
[16277] "Cytochrome-P450_Reductase"                                                                                                                                            
[16278] "Namibia"                                                                                                                                                              
[16279] "National_Academy_of_Science"                                                                                                                                          
[16280] "National_Center_for_Health_Statistics"                                                                                                                                
[16281] "National_Institute_of_Mental_Health"                                                                                                                                  
[16282] "National_Institutes_of_Health"                                                                                                                                        
[16283] "Nauru"                                                                                                                                                                
[16284] "Necrosis"                                                                                                                                                             
[16285] "NEF_Protein"                                                                                                                                                          
[16286] "Stage"                                                                                                                                                                
[16287] "Neovascularization"                                                                                                                                                   
[16288] "Nepal"                                                                                                                                                                
[16289] "Nephrology"                                                                                                                                                           
[16290] "Netherlands"                                                                                                                                                          
[16291] "Netherlands_Antilles"                                                                                                                                                 
[16292] "Neuroanatomy"                                                                                                                                                         
[16293] "Neurochemistry"                                                                                                                                                       
[16294] "Neuroendocrinology"                                                                                                                                                   
[16295] "Neurology"                                                                                                                                                            
[16296] "Neuropharmacology"                                                                                                                                                    
[16297] "Neurophysiology"                                                                                                                                                      
[16298] "Neuropsychology"                                                                                                                                                      
[16299] "Neurosciences"                                                                                                                                                        
[16300] "New_Caledonia"                                                                                                                                                        
[16301] "New_Zealand"                                                                                                                                                          
[16302] "Nicaragua"                                                                                                                                                            
[16303] "Niger"                                                                                                                                                                
[16304] "Nigeria"                                                                                                                                                              
[16305] "Niue"                                                                                                                                                                 
[16306] "Norfolk_Island"                                                                                                                                                       
[16307] "Norway"                                                                                                                                                               
[16308] "Nuclear_Magnetic_Resonance"                                                                                                                                           
[16309] "Nuclear_Medicine"                                                                                                                                                     
[16310] "Nuclear_Protein"                                                                                                                                                      
[16311] "Nucleic_Acid_Hybridization"                                                                                                                                           
[16312] "Nucleotidyltransferase"                                                                                                                                               
[16313] "Nursing"                                                                                                                                                              
[16314] "Nutritional_Science"                                                                                                                                                  
[16315] "Obstetrics"                                                                                                                                                           
[16316] "Occupational_Exposure"                                                                                                                                                
[16317] "Occupational_Health_Nursing"                                                                                                                                          
[16318] "Occupational_Medicine"                                                                                                                                                
[16319] "Odds_Ratio"                                                                                                                                                           
[16320] "Oman"                                                                                                                                                                 
[16321] "Oncoprotein"                                                                                                                                                          
[16322] "Viral_Oncogene_Protein"                                                                                                                                               
[16323] "Oncogene"                                                                                                                                                             
[16324] "Oncology_Nursing"                                                                                                                                                     
[16325] "Oogenesis"                                                                                                                                                            
[16326] "Ophthalmology"                                                                                                                                                        
[16327] "Optics"                                                                                                                                                               
[16328] "Organ_Culture"                                                                                                                                                        
[16329] "Orthopedics"                                                                                                                                                          
[16330] "Otolaryngology"                                                                                                                                                       
[16331] "Oxidation"                                                                                                                                                            
[16332] "Oxidation-Reduction"                                                                                                                                                  
[16333] "Oxidoreductase"                                                                                                                                                       
[16334] "Plasminogen_Activator_Inhibitor-1"                                                                                                                                    
[16335] "Plasminogen_Activator_Inhibitor-2"                                                                                                                                    
[16336] "Pakistan"                                                                                                                                                             
[16337] "Palpation"                                                                                                                                                            
[16338] "Panama"                                                                                                                                                               
[16339] "Papua_New_Guinea"                                                                                                                                                     
[16340] "Paraguay"                                                                                                                                                             
[16341] "Parasitology"                                                                                                                                                         
[16342] "Parity"                                                                                                                                                               
[16343] "Pathologic_Process"                                                                                                                                                   
[16344] "Oral_Pathology"                                                                                                                                                       
[16345] "Surgical_Pathology"                                                                                                                                                   
[16346] "Patient_Education"                                                                                                                                                    
[16347] "Patient"                                                                                                                                                              
[16348] "Pattern_Recognition"                                                                                                                                                  
[16349] "Pediatrics"                                                                                                                                                           
[16350] "Peer_Review"                                                                                                                                                          
[16351] "Beta-Lactamase"                                                                                                                                                       
[16352] "Protease"                                                                                                                                                             
[16353] "Peptide_Synthesis"                                                                                                                                                    
[16354] "Perception"                                                                                                                                                           
[16355] "Peristalsis"                                                                                                                                                          
[16356] "Laparoscopy"                                                                                                                                                          
[16357] "Permease"                                                                                                                                                             
[16358] "Permissiveness_Behavior"                                                                                                                                              
[16359] "Peru"                                                                                                                                                                 
[16360] "Pharmacogenetics"                                                                                                                                                     
[16361] "Pharmacology"                                                                                                                                                         
[16362] "Clinical_Pharmacology"                                                                                                                                                
[16363] "Pharmaceutics"                                                                                                                                                        
[16364] "Phenotype"                                                                                                                                                            
[16365] "Philippines"                                                                                                                                                          
[16366] "Phospholipase-A2"                                                                                                                                                     
[16367] "Phospholipase"                                                                                                                                                        
[16368] "Phosphatase"                                                                                                                                                          
[16369] "Phosphoprotein"                                                                                                                                                       
[16370] "Phosphorylation"                                                                                                                                                      
[16371] "Phosphotransferase"                                                                                                                                                   
[16372] "Photochemistry"                                                                                                                                                       
[16373] "Photosynthesis"                                                                                                                                                       
[16374] "Physical_Sciences"                                                                                                                                                    
[16375] "Physician_Office"                                                                                                                                                     
[16376] "Physics"                                                                                                                                                              
[16377] "Physiology"                                                                                                                                                           
[16378] "Comparative_Physiology"                                                                                                                                               
[16379] "Physiologic_Process"                                                                                                                                                  
[16380] "Pitcairn_Island"                                                                                                                                                      
[16381] "Plasminogen"                                                                                                                                                          
[16382] "Tissue_Plasminogen_Activator"                                                                                                                                         
[16383] "Plasminogen_Activator"                                                                                                                                                
[16384] "Plasminogen_Activator_Inhibitor"                                                                                                                                      
[16385] "Platelet_Activating_Factor"                                                                                                                                           
[16386] "Platelet_Aggregation"                                                                                                                                                 
[16387] "Pleomorphism"                                                                                                                                                         
[16388] "Ploidy"                                                                                                                                                               
[16389] "Poland"                                                                                                                                                               
[16390] "Polymerase_Chain_Reaction"                                                                                                                                            
[16391] "Genetic_Polymorphism"                                                                                                                                                 
[16392] "Population_Group"                                                                                                                                                     
[16393] "Portugal"                                                                                                                                                             
[16394] "Positron_Emission_Tomography"                                                                                                                                         
[16395] "Potassium_Channel"                                                                                                                                                    
[16396] "Poverty"                                                                                                                                                              
[16397] "Prevalence"                                                                                                                                                           
[16398] "Preventive_Medicine"                                                                                                                                                  
[16399] "Proctoscopy"                                                                                                                                                          
[16400] "Prognosis"                                                                                                                                                            
[16401] "Prophase"                                                                                                                                                             
[16402] "Cyclooxygenase"                                                                                                                                                       
[16403] "Prosthodontics"                                                                                                                                                       
[16404] "Protein_Kinase-C"                                                                                                                                                     
[16405] "Protein_Kinase"                                                                                                                                                       
[16406] "Post-Translational_Modification"                                                                                                                                      
[16407] "Protein_Tyrosine_Kinase"                                                                                                                                              
[16408] "Protein"                                                                                                                                                              
[16409] "Proteoglycan"                                                                                                                                                         
[16410] "Proto-Oncogene"                                                                                                                                                       
[16411] "Proton"                                                                                                                                                               
[16412] "Psychiatric_Nursing"                                                                                                                                                  
[16413] "Psychiatry"                                                                                                                                                           
[16414] "Psychology"                                                                                                                                                           
[16415] "Clinical_Psychology"                                                                                                                                                  
[16416] "Comparative_Psychology"                                                                                                                                               
[16417] "Educational_Psychology"                                                                                                                                               
[16418] "Experimental_Psychiatry"                                                                                                                                              
[16419] "Psychology_Industrial"                                                                                                                                                
[16420] "Social_Psychology"                                                                                                                                                    
[16421] "Psychometrics"                                                                                                                                                        
[16422] "Psychopathology"                                                                                                                                                      
[16423] "Psychopharmacology"                                                                                                                                                   
[16424] "Psychophysiology"                                                                                                                                                     
[16425] "Psychosomatic_Medicine"                                                                                                                                               
[16426] "Public_Health"                                                                                                                                                        
[16427] "Public_Health_Nursing"                                                                                                                                                
[16428] "Public_Policy"                                                                                                                                                        
[16429] "Public_Relations"                                                                                                                                                     
[16430] "Puerto_Rico"                                                                                                                                                          
[16431] "Pulse_Radiolysis"                                                                                                                                                     
[16432] "Qatar"                                                                                                                                                                
[16433] "Quality_of_Care"                                                                                                                                                      
[16434] "Quality_of_Life"                                                                                                                                                      
[16435] "Questionnaire"                                                                                                                                                        
[16436] "Race"                                                                                                                                                                 
[16437] "Electromagnetic_Radiation"                                                                                                                                            
[16438] "Radiation_Sensitivity"                                                                                                                                                
[16439] "Ionizing_Radiation"                                                                                                                                                   
[16440] "Nonionizing_Radiation"                                                                                                                                                
[16441] "Radioactivity"                                                                                                                                                        
[16442] "Radiation_Biology"                                                                                                                                                    
[16443] "Radiochemistry"                                                                                                                                                       
[16444] "Radioimmunoassay"                                                                                                                                                     
[16445] "Radiologic_Health"                                                                                                                                                    
[16446] "Radiology"                                                                                                                                                            
[16447] "HRAS_Gene"                                                                                                                                                            
[16448] "RAS_Family_Oncogene"                                                                                                                                                  
[16449] "Beta_Adrenergic_Receptor"                                                                                                                                             
[16450] "Androgen_Receptor"                                                                                                                                                    
[16451] "MAS1_Protein"                                                                                                                                                         
[16452] "T-Cell_Receptor"                                                                                                                                                      
[16453] "Dopamine_Receptor"                                                                                                                                                    
[16454] "Cell_Surface_Receptor"                                                                                                                                                
[16455] "Epidermal_Growth_Factor_Receptor"                                                                                                                                     
[16456] "Estrogen_Receptor"                                                                                                                                                    
[16457] "Fc_Receptor"                                                                                                                                                          
[16458] "Glucocorticoid_Receptor"                                                                                                                                              
[16459] "Insulin_Receptor"                                                                                                                                                     
[16460] "Interleukin-2_Receptor_Alpha"                                                                                                                                         
[16461] "Low_Density_Lipoprotein_Receptor"                                                                                                                                     
[16462] "Progesterone_Receptor"                                                                                                                                                
[16463] "Prolactin_Receptor"                                                                                                                                                   
[16464] "Purinergic_Receptor"                                                                                                                                                  
[16465] "Thyroid_Hormone_Receptor"                                                                                                                                             
[16466] "Transferrin_Receptor"                                                                                                                                                 
[16467] "Viral_Receptor"                                                                                                                                                       
[16468] "Recombinant_Protein"                                                                                                                                                  
[16469] "Recombination"                                                                                                                                                        
[16470] "Regeneration"                                                                                                                                                         
[16471] "REL_Gene"                                                                                                                                                             
[16472] "Religion"                                                                                                                                                             
[16473] "Repression"                                                                                                                                                           
[16474] "Reproduction"                                                                                                                                                         
[16475] "Request_for_Proposals"                                                                                                                                                
[16476] "Research_Personnel"                                                                                                                                                   
[16477] "Research_Support"                                                                                                                                                     
[16478] "Respiration"                                                                                                                                                          
[16479] "Respiratory_Physiology"                                                                                                                                               
[16480] "Restriction_Fragment_Length_Polymorphism"                                                                                                                             
[16481] "Restriction_Enzyme_Mapping"                                                                                                                                           
[16482] "Reunion"                                                                                                                                                              
[16483] "Reverse_Transcriptase"                                                                                                                                                
[16484] "Reverse_Transcription"                                                                                                                                                
[16485] "Rheumatology"                                                                                                                                                         
[16486] "Ribonuclease"                                                                                                                                                         
[16487] "Ribonucleotide_Reductase"                                                                                                                                             
[16488] "Risk"                                                                                                                                                                 
[16489] "Risk_Factor"                                                                                                                                                          
[16490] "DNA-Directed_RNA_Polymerase"                                                                                                                                          
[16491] "RNA-Directed_RNA_Polymerase"                                                                                                                                          
[16492] "RNA_Splicing"                                                                                                                                                         
[16493] "tRNA_Methyltransferase"                                                                                                                                               
[16494] "Romania"                                                                                                                                                              
[16495] "Rural_Health"                                                                                                                                                         
[16496] "Rural_Population"                                                                                                                                                     
[16497] "Russia"                                                                                                                                                               
[16498] "Rwanda"                                                                                                                                                               
[16499] "Saint_Lucia"                                                                                                                                                          
[16500] "Saint_Vincent_and_the_Grenadines"                                                                                                                                     
[16501] "San_Marino"                                                                                                                                                           
[16502] "Sao_Tome_and_Principe"                                                                                                                                                
[16503] "Saudi_Arabia"                                                                                                                                                         
[16504] "School"                                                                                                                                                               
[16505] "Cellular_Secretion"                                                                                                                                                   
[16506] "Support_Group"                                                                                                                                                        
[16507] "Senegal"                                                                                                                                                              
[16508] "Serine_Proteinase_Inhibitor"                                                                                                                                          
[16509] "Serine_Protease"                                                                                                                                                      
[16510] "Serpin"                                                                                                                                                               
[16511] "Serum_Globulin"                                                                                                                                                       
[16512] "Serum_Protein"                                                                                                                                                        
[16513] "Sex_Behavior"                                                                                                                                                         
[16514] "Sex_Hormone-Binding_Globulin"                                                                                                                                         
[16515] "Seychelles"                                                                                                                                                           
[16516] "Sierra_Leone"                                                                                                                                                         
[16517] "Sigmoidoscopy"                                                                                                                                                        
[16518] "Signal_Transduction"                                                                                                                                                  
[16519] "Singapore"                                                                                                                                                            
[16520] "Oncogene_SIS"                                                                                                                                                         
[16521] "Sister_Chromatid_Exchange"                                                                                                                                            
[16522] "Skin_Test"                                                                                                                                                            
[16523] "Slovenia"                                                                                                                                                             
[16524] "Olfaction"                                                                                                                                                            
[16525] "Passive_Smoke_Exposure"                                                                                                                                               
[16526] "Social_Sciences"                                                                                                                                                      
[16527] "Social_Work"                                                                                                                                                          
[16528] "Sociology"                                                                                                                                                            
[16529] "Medical_Sociology"                                                                                                                                                    
[16530] "Sodium_Channel"                                                                                                                                                       
[16531] "Computer_Program"                                                                                                                                                     
[16532] "Computer_Software_Engineering"                                                                                                                                        
[16533] "Solomon_Islands"                                                                                                                                                      
[16534] "Somalia"                                                                                                                                                              
[16535] "SOS_Function"                                                                                                                                                         
[16536] "South_Africa"                                                                                                                                                         
[16537] "Spain"                                                                                                                                                                
[16538] "Medical_Specialty"                                                                                                                                                    
[16539] "Surgical_Specialty"                                                                                                                                                   
[16540] "Spectroscopy"                                                                                                                                                         
[16541] "Mass_Spectrometry"                                                                                                                                                    
[16542] "Spectroscopy_Raman"                                                                                                                                                   
[16543] "Speculum"                                                                                                                                                             
[16544] "Alaryngeal_Speech"                                                                                                                                                    
[16545] "Esophageal_Speech"                                                                                                                                                    
[16546] "Spermatogenesis"                                                                                                                                                      
[16547] "SRC_Family_Gene"                                                                                                                                                      
[16548] "Sri_Lanka"                                                                                                                                                            
[16549] "Saint_Helena"                                                                                                                                                         
[16550] "Saint_Pierre_and_Miquelon"                                                                                                                                            
[16551] "Staphylococcus_aureus_Protein-A"                                                                                                                                      
[16552] "Statistics"                                                                                                                                                           
[16553] "Stent"                                                                                                                                                                
[16554] "Cell_Fraction"                                                                                                                                                        
[16555] "Sudan"                                                                                                                                                                
[16556] "Sulfotransferase"                                                                                                                                                     
[16557] "Superoxide_Dismutase"                                                                                                                                                 
[16558] "Surgery"                                                                                                                                                              
[16559] "Oral_Surgery"                                                                                                                                                         
[16560] "Suriname"                                                                                                                                                             
[16561] "Survey"                                                                                                                                                               
[16562] "Survival"                                                                                                                                                             
[16563] "Svalbard_and_Jan_Mayen"                                                                                                                                               
[16564] "Swaziland"                                                                                                                                                            
[16565] "Sweden"                                                                                                                                                               
[16566] "Switzerland"                                                                                                                                                          
[16567] "Syria"                                                                                                                                                                
[16568] "Tajikistan"                                                                                                                                                           
[16569] "Taiwan"                                                                                                                                                               
[16570] "Tanzania"                                                                                                                                                             
[16571] "TAT_Protein"                                                                                                                                                          
[16572] "Technology"                                                                                                                                                           
[16573] "Telecommunications"                                                                                                                                                   
[16574] "Telophase"                                                                                                                                                            
[16575] "Steroid_5-Alpha-Reductase-2"                                                                                                                                          
[16576] "Dihydrofolate_Reductase"                                                                                                                                              
[16577] "Thailand"                                                                                                                                                             
[16578] "Thermodynamics"                                                                                                                                                       
[16579] "Thermography"                                                                                                                                                         
[16580] "Thoracic_Surgery"                                                                                                                                                     
[16581] "Thoracoscopy"                                                                                                                                                         
[16582] "Coagulation_Factor-III"                                                                                                                                               
[16583] "Thymidine_Kinase"                                                                                                                                                     
[16584] "Thymidylate_Synthase"                                                                                                                                                 
[16585] "East_Timor"                                                                                                                                                           
[16586] "Tissue_Culture"                                                                                                                                                       
[16587] "Togo"                                                                                                                                                                 
[16588] "Single_Photon_Emission_Computed_Tomography"                                                                                                                           
[16589] "Computed_Tomography"                                                                                                                                                  
[16590] "Tonga"                                                                                                                                                                
[16591] "Toxicology"                                                                                                                                                           
[16592] "Transcription_Factor"                                                                                                                                                 
[16593] "Transcription"                                                                                                                                                        
[16594] "Transfection"                                                                                                                                                         
[16595] "Transferase"                                                                                                                                                          
[16596] "Transferrin"                                                                                                                                                          
[16597] "Transformation"                                                                                                                                                       
[16598] "Translation"                                                                                                                                                          
[16599] "Transmission"                                                                                                                                                         
[16600] "Transplantation_Immunology"                                                                                                                                           
[16601] "Trends"                                                                                                                                                               
[16602] "Trinidad_and_Tobago"                                                                                                                                                  
[16603] "Tryptophanase"                                                                                                                                                        
[16604] "Tubulin"                                                                                                                                                              
[16605] "Tumor_Marker"                                                                                                                                                         
[16606] "Tunisia"                                                                                                                                                              
[16607] "Turkey"                                                                                                                                                               
[16608] "Turkmenistan"                                                                                                                                                         
[16609] "Turks_and_Caicos_Islands"                                                                                                                                             
[16610] "Tuvalu"                                                                                                                                                               
[16611] "Tyrosinase"                                                                                                                                                           
[16612] "Ubiquitin"                                                                                                                                                            
[16613] "Uganda"                                                                                                                                                               
[16614] "Ukraine"                                                                                                                                                              
[16615] "Ultrasound_Imaging"                                                                                                                                                   
[16616] "Ultraviolet_Radiation"                                                                                                                                                
[16617] "United_Arab_Emirates"                                                                                                                                                 
[16618] "United_Kingdom"                                                                                                                                                       
[16619] "United_States"                                                                                                                                                        
[16620] "Department_of_Health_and_Human_Services"                                                                                                                              
[16621] "Environmental_Protection_Agency"                                                                                                                                      
[16622] "Food_and_Drug_Administration"                                                                                                                                         
[16623] "Public_Health_Service"                                                                                                                                                
[16624] "Veterans_Administration"                                                                                                                                              
[16625] "Urban_Population"                                                                                                                                                     
[16626] "Urinalysis"                                                                                                                                                           
[16627] "Urokinase"                                                                                                                                                            
[16628] "Urology"                                                                                                                                                              
[16629] "Uruguay"                                                                                                                                                              
[16630] "E-Cadherin"                                                                                                                                                           
[16631] "Uzbekistan"                                                                                                                                                           
[16632] "Vanuatu"                                                                                                                                                              
[16633] "Genetic_Variation"                                                                                                                                                    
[16634] "Vatican_City"                                                                                                                                                         
[16635] "Venezuela"                                                                                                                                                            
[16636] "Veterinary_Medicine"                                                                                                                                                  
[16637] "Vietnam"                                                                                                                                                              
[16638] "Viral_Genome"                                                                                                                                                         
[16639] "Viral_Protein"                                                                                                                                                        
[16640] "United_States_Virgin_Islands"                                                                                                                                         
[16641] "Virology"                                                                                                                                                             
[16642] "Visual_Perception"                                                                                                                                                    
[16643] "Vital_Statistics"                                                                                                                                                     
[16644] "Wallis_and_Futuna_Islands"                                                                                                                                            
[16645] "Wound_Repair"                                                                                                                                                         
[16646] "Diagnostic_Radiology"                                                                                                                                                 
[16647] "X-Ray"                                                                                                                                                                
[16648] "Xeroradiography"                                                                                                                                                      
[16649] "Yemen"                                                                                                                                                                
[16650] "Serbia_and_Montenegro"                                                                                                                                                
[16651] "Democratic_Republic_of_the_Congo"                                                                                                                                     
[16652] "Zambia"                                                                                                                                                               
[16653] "Zimbabwe"                                                                                                                                                             
[16654] "Zoology"                                                                                                                                                              
[16655] "Phosphatidylinositol-3_Kinase"                                                                                                                                        
[16656] "Amino_Acid_Transporter"                                                                                                                                               
[16657] "Thrombin-Antithrombin_Complex"                                                                                                                                        
[16658] "Aryl_Hydrocarbon_Receptor"                                                                                                                                            
[16659] "Bone_Morphogenetic_Protein"                                                                                                                                           
[16660] "Calcineurin"                                                                                                                                                          
[16661] "Cathepsin-H"                                                                                                                                                          
[16662] "Cathepsin-L"                                                                                                                                                          
[16663] "Azurocidin"                                                                                                                                                           
[16664] "CD22_Antigen"                                                                                                                                                         
[16665] "CD34_Antigen"                                                                                                                                                         
[16666] "CD40L_Receptor"                                                                                                                                                       
[16667] "Protein_Tyrosine_Phosphatase_Receptor_Type-C"                                                                                                                         
[16668] "Vitronectin"                                                                                                                                                          
[16669] "Chromogranin-A"                                                                                                                                                       
[16670] "CRE_Recombinase"                                                                                                                                                      
[16671] "cAMP_Responsive_Element_Binding_Protein"                                                                                                                              
[16672] "Cytochrome-P450-2D6"                                                                                                                                                  
[16673] "dGTPase"                                                                                                                                                              
[16674] "Dihydroorotate_Dehydrogenase"                                                                                                                                         
[16675] "Dihydropyrimidine_Dehydrogenase"                                                                                                                                      
[16676] "DNA_Primase"                                                                                                                                                          
[16677] "Dopamine_Receptor-D2"                                                                                                                                                 
[16678] "Vascular_Endothelial_Growth_Factor_Receptor"                                                                                                                          
[16679] "Transcription_Factor-AP2_Alpha"                                                                                                                                       
[16680] "Erythropoietin_Receptor"                                                                                                                                              
[16681] "Cytochrome-P450-1A1"                                                                                                                                                  
[16682] "Fibroblast_Growth_Factor_Receptor_Family"                                                                                                                             
[16683] "GTPase-Activating_Protein"                                                                                                                                            
[16684] "Haptoglobin-Related_Protein"                                                                                                                                          
[16685] "Heparan_Sulfate_Proteoglycan"                                                                                                                                         
[16686] "Heparinase"                                                                                                                                                           
[16687] "Histone_Acetylase"                                                                                                                                                    
[16688] "Integrase"                                                                                                                                                            
[16689] "Intercellular_Adhesion_Molecule-1"                                                                                                                                    
[16690] "Ku_Protein"                                                                                                                                                           
[16691] "Laminin_Receptor-1"                                                                                                                                                   
[16692] "Lamin"                                                                                                                                                                
[16693] "CD18_Antigen"                                                                                                                                                         
[16694] "p56-LCK"                                                                                                                                                              
[16695] "Melatonin_Receptor"                                                                                                                                                   
[16696] "Methylenetetrahydrofolate_Reductase"                                                                                                                                  
[16697] "Mineralocorticoid_Receptor"                                                                                                                                           
[16698] "Melanoma_Adhesion_Molecule"                                                                                                                                           
[16699] "Nucleoside_Diphosphate_Kinase-A"                                                                                                                                      
[16700] "O-6-Methylguanine-DNA_Methyltransferase"                                                                                                                              
[16701] "DBL_Oncoprotein"                                                                                                                                                      
[16702] "Papillomavirus_Type_16_Protein-E2"                                                                                                                                    
[16703] "Papillomavirus_Type_1_Protein-E4"                                                                                                                                     
[16704] "ERBB2_Receptor_Protein-Tyrosine_Kinase"                                                                                                                               
[16705] "Myb_Oncogene_Protein"                                                                                                                                                 
[16706] "Urokinase_Receptor"                                                                                                                                                   
[16707] "Platelet-Derived_Growth_Factor_Receptor"                                                                                                                              
[16708] "Proliferating_Cell_Nuclear_Antigen"                                                                                                                                   
[16709] "Plasminogen_Activator_Inhibitor-3"                                                                                                                                    
[16710] "Serine-Threonine_Protein_Kinase"                                                                                                                                      
[16711] "p53-LYN_Protein"                                                                                                                                                      
[16712] "MOS-pp39_Serine-Threonine_Kinase"                                                                                                                                     
[16713] "Stem_Cell_Factor_Receptor"                                                                                                                                            
[16714] "c-Myb_Protein"                                                                                                                                                        
[16715] "PS2_Protein"                                                                                                                                                          
[16716] "RHOB_Protein"                                                                                                                                                         
[16717] "Insulin-Like_Growth_Factor-Binding_Protein"                                                                                                                           
[16718] "Somatostatin_Receptor"                                                                                                                                                
[16719] "Streptavidin"                                                                                                                                                         
[16720] "Syndecans"                                                                                                                                                            
[16721] "CD28_Antigen"                                                                                                                                                         
[16722] "Taq_Polymerase"                                                                                                                                                       
[16723] "Tenascin-C"                                                                                                                                                           
[16724] "Thrombospondin"                                                                                                                                                       
[16725] "Topoisomerase-III"                                                                                                                                                    
[16726] "Transforming_Growth_Factor_Beta_Receptor_II"                                                                                                                          
[16727] "Nerve_Growth_Factor_Receptor"                                                                                                                                         
[16728] "Troponin-I"                                                                                                                                                           
[16729] "Tumor_Necrosis_Factor_Receptor"                                                                                                                                       
[16730] "Vasopressin_Receptor"                                                                                                                                                 
[16731] "ABL1_Gene"                                                                                                                                                            
[16732] "CD-ROM"                                                                                                                                                               
[16733] "Pap_Smear"                                                                                                                                                            
[16734] "Cyclin"                                                                                                                                                               
[16735] "DNA_Fingerprinting"                                                                                                                                                   
[16736] "Extracellular_Matrix_Protein"                                                                                                                                         
[16737] "Facility_Construction"                                                                                                                                                
[16738] "Fluorescence_Activated_Cell_Sorting"                                                                                                                                  
[16739] "Frameshift_Mutation"                                                                                                                                                  
[16740] "G1-Phase"                                                                                                                                                             
[16741] "G2-Phase"                                                                                                                                                             
[16742] "Gender"                                                                                                                                                               
[16743] "DCC_Gene"                                                                                                                                                             
[16744] "TP53_Gene"                                                                                                                                                            
[16745] "RB1_Gene"                                                                                                                                                             
[16746] "REX_Gene"                                                                                                                                                             
[16747] "Tumor_Suppressor_Gene"                                                                                                                                                
[16748] "TAX_Gene"                                                                                                                                                             
[16749] "Wilms_Tumor_Gene"                                                                                                                                                     
[16750] "HTLV-I_REX_Gene"                                                                                                                                                      
[16751] "HTLV-I_TAX_Gene"                                                                                                                                                      
[16752] "HTLV-II_REX_Gene"                                                                                                                                                     
[16753] "HTLV-II_TAX_Gene"                                                                                                                                                     
[16754] "Imaging_Technique"                                                                                                                                                    
[16755] "Fluorescent_Antibody_Technique"                                                                                                                                       
[16756] "L-Myc_Protein"                                                                                                                                                        
[16757] "Integrin_Alpha-L"                                                                                                                                                     
[16758] "Integrin_Alpha-M"                                                                                                                                                     
[16759] "Scanning_Tunneling_Microscopy"                                                                                                                                        
[16760] "Murine_AIDS"                                                                                                                                                          
[16761] "Mutagenesis"                                                                                                                                                          
[16762] "Insertional_Mutagenesis"                                                                                                                                              
[16763] "Site-Directed_Mutagenesis"                                                                                                                                            
[16764] "N-Myc_Protein"                                                                                                                                                        
[16765] "NF-kB"                                                                                                                                                                
[16766] "Occupational_Health"                                                                                                                                                  
[16767] "p21_H-Ras_Protein"                                                                                                                                                    
[16768] "p21_K-Ras_Protein"                                                                                                                                                    
[16769] "p21_N-Ras_Protein"                                                                                                                                                    
[16770] "Privacy"                                                                                                                                                              
[16771] "Cyclin-Dependent_Kinase-1"                                                                                                                                            
[16772] "Tumor_Protein-p53"                                                                                                                                                    
[16773] "p21_RAS_Protein"                                                                                                                                                      
[16774] "p60-SRC"                                                                                                                                                              
[16775] "ABL1_Tyrosine_Kinase"                                                                                                                                                 
[16776] "c-MYC_Protein"                                                                                                                                                        
[16777] "Colony_Stimulating_Factor-1_Receptor"                                                                                                                                 
[16778] "Colony_Stimulating_Factor_Receptor"                                                                                                                                   
[16779] "RB_Protein"                                                                                                                                                           
[16780] "S-Phase"                                                                                                                                                              
[16781] "Sequence_Tagged_Site"                                                                                                                                                 
[16782] "Oncogene_ABL1"                                                                                                                                                        
[16783] "Oncogene_SRC"                                                                                                                                                         
[16784] "Women_s_Health"                                                                                                                                                       
[16785] "Speech_Pathology"                                                                                                                                                     
[16786] "B-MYB_Protein"                                                                                                                                                        
[16787] "CD31_Antigen"                                                                                                                                                         
[16788] "Lymphocyte_Function-Associated_Antigen-3"                                                                                                                             
[16789] "CD72_Antigen"                                                                                                                                                         
[16790] "Topoisomerase-IV"                                                                                                                                                     
[16791] "Endoglin"                                                                                                                                                             
[16792] "Ecotropic_Virus_Integration-1_Site_Protein"                                                                                                                           
[16793] "MAP-Kinase-3"                                                                                                                                                         
[16794] "FK506_Binding_Protein"                                                                                                                                                
[16795] "GLI3_Protein"                                                                                                                                                         
[16796] "Fibroblast_Growth_Factor_Receptor-2"                                                                                                                                  
[16797] "Neurofibromin"                                                                                                                                                        
[16798] "Sperm_Adhesion_Molecule-1"                                                                                                                                            
[16799] "CRK_Protein"                                                                                                                                                          
[16800] "RHOA_Protein"                                                                                                                                                         
[16801] "RHOC_Protein"                                                                                                                                                         
[16802] "RNA_Helicase"                                                                                                                                                         
[16803] "SCL_Transcription_Factor"                                                                                                                                             
[16804] "SPT6_Protein"                                                                                                                                                         
[16805] "PEA3"                                                                                                                                                                 
[16806] "CHO_Cells"                                                                                                                                                            
[16807] "NIH_3T3"                                                                                                                                                              
[16808] "Drug_Delivery_System"                                                                                                                                                 
[16809] "NF1_Gene"                                                                                                                                                             
[16810] "NF2_Gene"                                                                                                                                                             
[16811] "Pulsed-Field_Gel_Electrophoresis"                                                                                                                                     
[16812] "Smoking_Cessation"                                                                                                                                                    
[16813] "Glucose_Phosphate_Isomerase"                                                                                                                                          
[16814] "Neural_Network"                                                                                                                                                       
[16815] "Vinculin"                                                                                                                                                             
[16816] "HIV-p24_Antigen"                                                                                                                                                      
[16817] "T-Cell_Receptor_Gamma-Delta"                                                                                                                                          
[16818] "T-Cell_Receptor_Alpha-Beta"                                                                                                                                           
[16819] "Glycosyltransferase"                                                                                                                                                  
[16820] "PC-12"                                                                                                                                                                
[16821] "Immunoscintigraphy"                                                                                                                                                   
[16822] "JUN_Protein"                                                                                                                                                          
[16823] "FOS_Protein"                                                                                                                                                          
[16824] "FOS_Oncoprotein"                                                                                                                                                      
[16825] "Oncogene_FOS"                                                                                                                                                         
[16826] "CD8_Antigen_Beta_Polypeptide-1"                                                                                                                                       
[16827] "Anisotropy"                                                                                                                                                           
[16828] "Adverse_Drug_Experience_Reporting_System"                                                                                                                             
[16829] "Protein_Tyrosine_Phosphatase"                                                                                                                                         
[16830] "Caregiver"                                                                                                                                                            
[16831] "Catheter"                                                                                                                                                             
[16832] "Serine_Protease_Inhibitor_Kazal_Type-1"                                                                                                                               
[16833] "Antibiotic_Resistance"                                                                                                                                                
[16834] "AP-1"                                                                                                                                                                 
[16835] "FOS_Family_Gene"                                                                                                                                                      
[16836] "JUN_Family_Gene"                                                                                                                                                      
[16837] "Conference"                                                                                                                                                           
[16838] "Diagnostic_Test"                                                                                                                                                      
[16839] "Enzyme_Immunoassay"                                                                                                                                                   
[16840] "Experimental_Model"                                                                                                                                                   
[16841] "Molecular_Genetics"                                                                                                                                                   
[16842] "G_Protein"                                                                                                                                                            
[16843] "Hispanic"                                                                                                                                                             
[16844] "Histone-H2B"                                                                                                                                                          
[16845] "Initiation_Factor"                                                                                                                                                    
[16846] "JUNB_Protein"                                                                                                                                                         
[16847] "JUND_Protein"                                                                                                                                                         
[16848] "Oncogene_MYC"                                                                                                                                                         
[16849] "Personal_Communication"                                                                                                                                               
[16850] "Rous_Sarcoma"                                                                                                                                                         
[16851] "Senescence"                                                                                                                                                           
[16852] "Socioeconomic_Factors"                                                                                                                                                
[16853] "Taxonomy"                                                                                                                                                             
[16854] "Telomerase"                                                                                                                                                           
[16855] "Youth"                                                                                                                                                                
[16856] "Acylaminoacyl-Peptidase"                                                                                                                                              
[16857] "E1A_Protein"                                                                                                                                                          
[16858] "E1B_Protein"                                                                                                                                                          
[16859] "AXL_Protein"                                                                                                                                                          
[16860] "B-RAF_Protein_Kinase"                                                                                                                                                 
[16861] "BCR_Protein"                                                                                                                                                          
[16862] "Beta_Catenin"                                                                                                                                                         
[16863] "Human_Chorionic_Gonadotropin_Beta_Subunit"                                                                                                                            
[16864] "BMI1_Protein"                                                                                                                                                         
[16865] "ETS1_Protein"                                                                                                                                                         
[16866] "ETS2_Protein"                                                                                                                                                         
[16867] "p55-FGR"                                                                                                                                                              
[16868] "RAF-1_Protein"                                                                                                                                                        
[16869] "Vitamin-D3_Receptor"                                                                                                                                                  
[16870] "CCAAT_Enhancer_Binding_Protein"                                                                                                                                       
[16871] "Fc-Gamma_Receptor-III"                                                                                                                                                
[16872] "CD14_Antigen"                                                                                                                                                         
[16873] "Cytotoxic_T-Lymphocyte-Associated_Protein-4"                                                                                                                          
[16874] "Cyclin_E"                                                                                                                                                             
[16875] "E-Selectin"                                                                                                                                                           
[16876] "FAT_Protein"                                                                                                                                                          
[16877] "GATA-1"                                                                                                                                                               
[16878] "Guanine_Nucleotide_Exchange_Factor"                                                                                                                                   
[16879] "Ephrin_Receptor-EphA3"                                                                                                                                                
[16880] "Hh-1_Antigen"                                                                                                                                                         
[16881] "HOX11_Protein"                                                                                                                                                        
[16882] "Papillomavirus_Type_8_Protein-E7"                                                                                                                                     
[16883] "Papillomavirus_Type_18_Protein-E2"                                                                                                                                    
[16884] "Papillomavirus_Type_16_Protein-E5"                                                                                                                                    
[16885] "Papillomavirus_Type_16_Protein-E4"                                                                                                                                    
[16886] "Intercellular_Adhesion_Molecule-2"                                                                                                                                    
[16887] "Intercellular_Adhesion_Molecule-3"                                                                                                                                    
[16888] "Insulin-Like_Growth_Factor-Binding_Protein-1"                                                                                                                         
[16889] "Insulin-Like_Growth_Factor-Binding_Protein-2"                                                                                                                         
[16890] "Insulin-Like_Growth_Factor-Binding_Protein-4"                                                                                                                         
[16891] "Insulin-Like_Growth_Factor-Binding_Protein-5"                                                                                                                         
[16892] "Insulin-Like_Growth_Factor-Binding_Protein-3"                                                                                                                         
[16893] "WNT2_Protein"                                                                                                                                                         
[16894] "L-Plastin"                                                                                                                                                            
[16895] "Selectin-L"                                                                                                                                                           
[16896] "MAGE-3-1_Antigen"                                                                                                                                                     
[16897] "MCC_Protein"                                                                                                                                                          
[16898] "MDM2_Protein"                                                                                                                                                         
[16899] "APEH_Gene"                                                                                                                                                            
[16900] "Nuclear_Matrix_Protein"                                                                                                                                               
[16901] "Papillomavirus_Type_6_Protein-E4"                                                                                                                                     
[16902] "Papillomavirus_Type_11_Protein-E4"                                                                                                                                    
[16903] "Papillomavirus_Type_18_Protein-E6"                                                                                                                                    
[16904] "OTF-1"                                                                                                                                                                
[16905] "P-Selectin"                                                                                                                                                           
[16906] "Papillomavirus_Enhancer-Associated_Factor"                                                                                                                            
[16907] "Junction_Plakoglobin"                                                                                                                                                 
[16908] "Prostate-Specific_Antigen"                                                                                                                                            
[16909] "Farnesyl_Protein_Transferase"                                                                                                                                         
[16910] "Papillomavirus_Type_16_Protein-L1"                                                                                                                                    
[16911] "CSK_Protein_Kinase"                                                                                                                                                   
[16912] "Qa-1_Antigen"                                                                                                                                                         
[16913] "Insulin-Like_Growth_Factor_Receptor"                                                                                                                                  
[16914] "Insulin-Like_Growth_Factor-1_Receptor"                                                                                                                                
[16915] "Retinoic_Acid_Receptor"                                                                                                                                               
[16916] "Retinoic_Acid_Receptor_Alpha"                                                                                                                                         
[16917] "Retinoid-X_Receptor"                                                                                                                                                  
[16918] "RGD_Receptor"                                                                                                                                                         
[16919] "Sodium-Iodide_Symporter"                                                                                                                                              
[16920] "SPT5_Protein"                                                                                                                                                         
[16921] "T4_Endonuclease-V"                                                                                                                                                    
[16922] "OTF-2"                                                                                                                                                                
[16923] "TFIID"                                                                                                                                                                
[16924] "TFIIIB"                                                                                                                                                               
[16925] "TIMP-2"                                                                                                                                                               
[16926] "TIMP-1"                                                                                                                                                               
[16927] "Tissue_Inhibitor_of_Metalloproteinases"                                                                                                                               
[16928] "AP-2_Family_Transcription_Factor"                                                                                                                                     
[16929] "E2F_Transcription_Factor-1"                                                                                                                                           
[16930] "Thrombospondin-1"                                                                                                                                                     
[16931] "Proteinase-3"                                                                                                                                                         
[16932] "WT1_Protein"                                                                                                                                                          
[16933] "Hepatitis-B_X-Protein"                                                                                                                                                
[16934] "Advocacy"                                                                                                                                                             
[16935] "Ethnography"                                                                                                                                                          
[16936] "Clinical_Ethics"                                                                                                                                                      
[16937] "Transcriptional_Activation"                                                                                                                                           
[16938] "Oncogene_JUN"                                                                                                                                                         
[16939] "Worksite"                                                                                                                                                             
[16940] "Apoptosis"                                                                                                                                                            
[16941] "Echo-Planar_Imaging"                                                                                                                                                  
[16942] "Collagenase"                                                                                                                                                          
[16943] "Isoprenylation"                                                                                                                                                       
[16944] "Fusion_Protein"                                                                                                                                                       
[16945] "in_situ_Hybridization"                                                                                                                                                
[16946] "Fluorescence_in_situ_Hybridization"                                                                                                                                   
[16947] "Guidelines"                                                                                                                                                           
[16948] "Sequence_Analysis"                                                                                                                                                    
[16949] "MCC_Gene"                                                                                                                                                             
[16950] "APC_Gene"                                                                                                                                                             
[16951] "Protein_Folding"                                                                                                                                                      
[16952] "Aryldialkylphosphatase"                                                                                                                                               
[16953] "Nucleophosmin"                                                                                                                                                        
[16954] "Matrix_Metalloproteinase-3"                                                                                                                                           
[16955] "Focal_Adhesion_Kinase-1"                                                                                                                                              
[16956] "Cytochrome-P450-3A4"                                                                                                                                                  
[16957] "p59-FYN"                                                                                                                                                              
[16958] "Matrix_Metalloproteinase-9"                                                                                                                                           
[16959] "Papillomavirus_Type_6_Protein-E7"                                                                                                                                     
[16960] "Autocrine_Mobility_Factor_Receptor"                                                                                                                                   
[16961] "TATA_Box_Binding_Protein"                                                                                                                                             
[16962] "RAC-Alpha_Serine-Threonine_Kinase"                                                                                                                                    
[16963] "Protein_Kinase-B_Beta"                                                                                                                                                
[16964] "Tumor-Associated_Antigen-L6"                                                                                                                                          
[16965] "bZIP_Protein"                                                                                                                                                         
[16966] "I-Kappa-B_Protein"                                                                                                                                                    
[16967] "Forkhead_Box_Protein-G1B_Protein"                                                                                                                                     
[16968] "Erythrocyte-Brain_Glucose_Transporter_Type-1"                                                                                                                         
[16969] "Cyclin-Dependent_Kinase_Inhibitor-1C"                                                                                                                                 
[16970] "Insulin-Like_Growth_Factor-Binding_Protein-6"                                                                                                                         
[16971] "SPT3_Protein"                                                                                                                                                         
[16972] "Mitogen-Activated_Protein_Kinase-1"                                                                                                                                   
[16973] "Fibroblast_Growth_Factor_Receptor-1"                                                                                                                                  
[16974] "GRB2_Protein"                                                                                                                                                         
[16975] "Matrix_Metalloproteinase-2"                                                                                                                                           
[16976] "Zuotin"                                                                                                                                                               
[16977] "Matrix_Metalloproteinase-11"                                                                                                                                          
[16978] "HRX_Protein"                                                                                                                                                          
[16979] "Zeta-Chain_Associated_Protein_Kinase"                                                                                                                                 
[16980] "Adhesion"                                                                                                                                                             
[16981] "Prosthesis"                                                                                                                                                           
[16982] "Immunologist"                                                                                                                                                         
[16983] "Adult"                                                                                                                                                                
[16984] "Bacterial_Genetics"                                                                                                                                                   
[16985] "Critical_Care_Nursing"                                                                                                                                                
[16986] "Environmental_Toxicology"                                                                                                                                             
[16987] "Food_Preparation"                                                                                                                                                     
[16988] "Food_Science_and_Technology"                                                                                                                                          
[16989] "Image_Processing"                                                                                                                                                     
[16990] "Nucleocapsid_Protein"                                                                                                                                                 
[16991] "Plant_Genetics"                                                                                                                                                       
[16992] "Tumor_Progression"                                                                                                                                                    
[16993] "Blood_Sample"                                                                                                                                                         
[16994] "Bronchoscope"                                                                                                                                                         
[16995] "Central_Venous_Access_Catheter"                                                                                                                                       
[16996] "Colonoscope"                                                                                                                                                          
[16997] "Colposcope"                                                                                                                                                           
[16998] "Curette"                                                                                                                                                              
[16999] "Cystoscope"                                                                                                                                                           
[17000] "Dilator"                                                                                                                                                              
[17001] "Laryngoscope"                                                                                                                                                         
[17002] "Fluoroscope"                                                                                                                                                          
[17003] "Gastroscope"                                                                                                                                                          
[17004] "Humidifier"                                                                                                                                                           
[17005] "Ophthalmoscope"                                                                                                                                                       
[17006] "Patient_Monitoring_System"                                                                                                                                            
[17007] "Picture_Archiving_and_Communication_System"                                                                                                                           
[17008] "Pump"                                                                                                                                                                 
[17009] "Sigmoidoscope"                                                                                                                                                        
[17010] "Swab"                                                                                                                                                                 
[17011] "Tracheostomy_Button"                                                                                                                                                  
[17012] "Tracheostomy_Tube"                                                                                                                                                    
[17013] "Subcutaneous_Port"                                                                                                                                                    
[17014] "Digital_Rectal_Examination"                                                                                                                                           
[17015] "DNA_Analysis"                                                                                                                                                         
[17016] "Restriction_Fragment_Length_Polymorphism_Analysis"                                                                                                                    
[17017] "PSA_Assay"                                                                                                                                                            
[17018] "Tumor_Necrosis_Factor_Assay"                                                                                                                                          
[17019] "Antigen_Proliferation_Assay"                                                                                                                                          
[17020] "Capillary_Electrophoresis"                                                                                                                                            
[17021] "Immunoblot_Analysis"                                                                                                                                                  
[17022] "Upper_GI_Series"                                                                                                                                                      
[17023] "Esophagram"                                                                                                                                                           
[17024] "Percutaneous_Transhepatic_Cholangiography"                                                                                                                            
[17025] "Nephrotomogram"                                                                                                                                                       
[17026] "Intravenous_Pyelogram"                                                                                                                                                
[17027] "Transvaginal_Ultrasound"                                                                                                                                              
[17028] "Radionuclide_Scanning"                                                                                                                                                
[17029] "Bone_Scan"                                                                                                                                                            
[17030] "Liver_Scan"                                                                                                                                                           
[17031] "Multiple"                                                                                                                                                             
[17032] "Other"                                                                                                                                                                
[17033] "Physiologic"                                                                                                                                                          
[17034] "Waist-Hip_Ratio"                                                                                                                                                      
[17035] "Gerontology"                                                                                                                                                          
[17036] "British_Virgin_Islands"                                                                                                                                               
[17037] "The_Former_Yugoslav_Republic_of_Macedonia"                                                                                                                            
[17038] "Reproductive_History"                                                                                                                                                 
[17039] "Clonal_Regression"                                                                                                                                                    
[17040] "Molecular_Epidemiology"                                                                                                                                               
[17041] "Long_Term_Survivor"                                                                                                                                                   
[17042] "Survivor"                                                                                                                                                             
[17043] "Receptor_Tyrosine_Kinase"                                                                                                                                             
[17044] "Reporter_Gene"                                                                                                                                                        
[17045] "Antigen_Processing"                                                                                                                                                   
[17046] "Antigen_Presentation"                                                                                                                                                 
[17047] "Growth_Factor_Receptor"                                                                                                                                               
[17048] "Neural_Peptide_Receptor"                                                                                                                                              
[17049] "Germline_Mutation"                                                                                                                                                    
[17050] "Cytokine_Receptor"                                                                                                                                                    
[17051] "Czech_Republic"                                                                                                                                                       
[17052] "Slovakia"                                                                                                                                                             
[17053] "Cytoplasmic_Receptor"                                                                                                                                                 
[17054] "Nuclear_Receptor"                                                                                                                                                     
[17055] "X-Ray_Crystallography"                                                                                                                                                
[17056] "Cytochrome-P450-1A2"                                                                                                                                                  
[17057] "Human_Papillomavirus_Type_18_Protein_E7"                                                                                                                              
[17058] "Proliferation-Related-Ki-67_Antigen"                                                                                                                                  
[17059] "TAF-II-250_Protein"                                                                                                                                                   
[17060] "I-Kappa-B-Alpha_Protein"                                                                                                                                              
[17061] "Upstream_Stimulatory_Factor"                                                                                                                                          
[17062] "Cyclin-Dependent_Kinase-4"                                                                                                                                            
[17063] "TIMP-3"                                                                                                                                                               
[17064] "Multiple_Drug_Resistance-Associated_Protein"                                                                                                                          
[17065] "Core-Binding_Factor"                                                                                                                                                  
[17066] "Activating_Transcription_Factor-2"                                                                                                                                    
[17067] "ERBB4_Receptor_Protein_Tyrosine_Kinase"                                                                                                                               
[17068] "NF-Kappa-B-p65_Protein"                                                                                                                                               
[17069] "Adenomatous_Polyposis_Coli_Protein"                                                                                                                                   
[17070] "MCL-1_Protein"                                                                                                                                                        
[17071] "Cortactin"                                                                                                                                                            
[17072] "Hypoxia-Inducible_Factor-1"                                                                                                                                           
[17073] "c-Ros_Tyrosine_Kinase"                                                                                                                                                
[17074] "Reticulon-1"                                                                                                                                                          
[17075] "NK-Tumor_Recognition_Protein"                                                                                                                                         
[17076] "Cytochrome-P450-2C18"                                                                                                                                                 
[17077] "Thrombopoietin_Receptor"                                                                                                                                              
[17078] "RAB8_Protein"                                                                                                                                                         
[17079] "B_Lymphoid_Tyrosine_Kinase"                                                                                                                                           
[17080] "BCL-XL_Protein"                                                                                                                                                       
[17081] "BCL2-Associated_X_Protein"                                                                                                                                            
[17082] "CRKL_Protein"                                                                                                                                                         
[17083] "GLI_Family_Protein"                                                                                                                                                   
[17084] "Biosynthesis"                                                                                                                                                         
[17085] "Teratology"                                                                                                                                                           
[17086] "Tokelau"                                                                                                                                                              
[17087] "Training"                                                                                                                                                             
[17088] "Anergy"                                                                                                                                                               
[17089] "Thrombopoiesis"                                                                                                                                                       
[17090] "Physical_Activity"                                                                                                                                                    
[17091] "Cell-Mediated_Cytolysis"                                                                                                                                              
[17092] "Subcellular_Process"                                                                                                                                                  
[17093] "Prokaryotic_Cell_Component"                                                                                                                                           
[17094] "Immunologic_Tolerance"                                                                                                                                                
[17095] "Personality_Trait"                                                                                                                                                    
[17096] "Substance_Abuse_Other"                                                                                                                                                
[17097] "Discipline"                                                                                                                                                           
[17098] "Support_System"                                                                                                                                                       
[17099] "Uninsured_Medical_Expense"                                                                                                                                            
[17100] "Individual"                                                                                                                                                           
[17101] "Gynecologist"                                                                                                                                                         
[17102] "Neurologist"                                                                                                                                                          
[17103] "Neurosurgeon"                                                                                                                                                         
[17104] "Pathologist"                                                                                                                                                          
[17105] "Rural"                                                                                                                                                                
[17106] "Sun_Exposure"                                                                                                                                                         
[17107] "Family_Medical_History"                                                                                                                                               
[17108] "Pacific_Island_American"                                                                                                                                              
[17109] "Ligand_Binding_Protein"                                                                                                                                               
[17110] "Organogenesis"                                                                                                                                                        
[17111] "Fetal_Tissue"                                                                                                                                                         
[17112] "Immunocytochemistry"                                                                                                                                                  
[17113] "Visible_Light"                                                                                                                                                        
[17114] "Palau"                                                                                                                                                                
[17115] "At-Risk_Population"                                                                                                                                                   
[17116] "Policy"                                                                                                                                                               
[17117] "Thyroid_Hormone_Receptor_Beta"                                                                                                                                        
[17118] "Sperm_Preservation"                                                                                                                                                   
[17119] "Fluorescence_Spectroscopy"                                                                                                                                            
[17120] "American_Samoa"                                                                                                                                                       
[17121] "Samoa"                                                                                                                                                                
[17122] "Oxidative_Stress"                                                                                                                                                     
[17123] "Gene_Targeting"                                                                                                                                                       
[17124] "Genomic_Imprinting"                                                                                                                                                   
[17125] "Homeodomain_Protein"                                                                                                                                                  
[17126] "Multidrug_Resistance"                                                                                                                                                 
[17127] "P-Glycoprotein-1"                                                                                                                                                     
[17128] "Disease_Progression"                                                                                                                                                  
[17129] "Reproductive_Medicine"                                                                                                                                                
[17130] "Photobiology"                                                                                                                                                         
[17131] "ABC_Transporter"                                                                                                                                                      
[17132] "Disease-Free_Survival"                                                                                                                                                
[17133] "Fee_for_Service"                                                                                                                                                      
[17134] "Confocal_Microscopy"                                                                                                                                                  
[17135] "Atomic_Force_Microscopy"                                                                                                                                              
[17136] "Toxicity_Test"                                                                                                                                                        
[17137] "ERBB2_Gene"                                                                                                                                                           
[17138] "EGFR_Gene"                                                                                                                                                            
[17139] "Oncogene_ERB-A"                                                                                                                                                       
[17140] "Radiology_Therapeutic"                                                                                                                                                
[17141] "Radiation_Oncology"                                                                                                                                                   
[17142] "Cell_Cycle_Protein"                                                                                                                                                   
[17143] "Single-Stranded_Conformational_Polymorphism"                                                                                                                          
[17144] "Oncogene_ERB-B"                                                                                                                                                       
[17145] "Chaperone"                                                                                                                                                            
[17146] "Heat_Shock_Protein-70"                                                                                                                                                
[17147] "Heat_Shock_Protein-90"                                                                                                                                                
[17148] "Cyclin-Dependent_Kinase"                                                                                                                                              
[17149] "Cellular_Morphology"                                                                                                                                                  
[17150] "Funding"                                                                                                                                                              
[17151] "Development"                                                                                                                                                          
[17152] "Chemical_Properties"                                                                                                                                                  
[17153] "CD44_Antigen"                                                                                                                                                         
[17154] "Arylamine_N-Acetyltransferase-2"                                                                                                                                      
[17155] "TACSTD2_Gene"                                                                                                                                                         
[17156] "Telomeric-Repeat_Binding_Factor"                                                                                                                                      
[17157] "FAS_Antigen"                                                                                                                                                          
[17158] "BCL6_Protein"                                                                                                                                                         
[17159] "Proteasome-26S_Subunit_Non-ATPase-10"                                                                                                                                 
[17160] "FADD"                                                                                                                                                                 
[17161] "MAP-Kinase-8"                                                                                                                                                         
[17162] "RRAD_Protein"                                                                                                                                                         
[17163] "CDKN1A_Gene"                                                                                                                                                          
[17164] "Cyclin-Dependent_Kinase_Inhibitor-1A"                                                                                                                                 
[17165] "Cyclin-Dependent_Kinase-4_Inhibitor-B"                                                                                                                                
[17166] "Cyclin-Dependent_Kinase-5"                                                                                                                                            
[17167] "Cyclin-Dependent_Kinase_Inhibitor-2A"                                                                                                                                 
[17168] "M_Protein"                                                                                                                                                            
[17169] "SDF1-PBSF_Receptor-CXCR4"                                                                                                                                             
[17170] "Maspin"                                                                                                                                                               
[17171] "DAN_Protein"                                                                                                                                                          
[17172] "Collagen_XVIII_Alpha-1"                                                                                                                                               
[17173] "Growth_Arrest_and_DNA-Damage-Inducible_Alpha_Protein"                                                                                                                 
[17174] "MLH1_Protein"                                                                                                                                                         
[17175] "ISWI"                                                                                                                                                                 
[17176] "Folate_Hydrolase-1"                                                                                                                                                   
[17177] "Merlin"                                                                                                                                                               
[17178] "TEL_Protein"                                                                                                                                                          
[17179] "Fibroblast_Activation_Protein_Alpha"                                                                                                                                  
[17180] "Tumor_Necrosis_Factor_Alpha_Receptor"                                                                                                                                 
[17181] "Topoisomerase-II_Alpha"                                                                                                                                               
[17182] "Topoisomerase-II_Beta"                                                                                                                                                
[17183] "CREB_Binding_Protein"                                                                                                                                                 
[17184] "E1A_Binding_Protein-p300"                                                                                                                                             
[17185] "Protein_Kinase-C-alpha"                                                                                                                                               
[17186] "ETV3_Protein"                                                                                                                                                         
[17187] "Prostasin"                                                                                                                                                            
[17188] "MAP2K1_Protein"                                                                                                                                                       
[17189] "Kangai-1_Protein"                                                                                                                                                     
[17190] "A-MYB_Protein"                                                                                                                                                        
[17191] "D10S170_Protein"                                                                                                                                                      
[17192] "TNF_Receptor-Associated_Factor-2"                                                                                                                                     
[17193] "Orphan_Nuclear_Receptor-EAR2"                                                                                                                                         
[17194] "Elongin_Binding_Protein"                                                                                                                                              
[17195] "BRCA1_Protein"                                                                                                                                                        
[17196] "Dermatologist"                                                                                                                                                        
[17197] "Endocrinologist"                                                                                                                                                      
[17198] "Gastroenterologist"                                                                                                                                                   
[17199] "Experimental_Hematology"                                                                                                                                              
[17200] "Cell_Tissue_Histochemistry"                                                                                                                                           
[17201] "Oncologist"                                                                                                                                                           
[17202] "Ophthalmologist"                                                                                                                                                      
[17203] "Otolaryngologist"                                                                                                                                                     
[17204] "Radiologist"                                                                                                                                                          
[17205] "Oral_Surgeon"                                                                                                                                                         
[17206] "Urologist"                                                                                                                                                            
[17207] "Information_Resources_Management"                                                                                                                                     
[17208] "Biological_Process"                                                                                                                                                   
[17209] "Gynecologic_Oncology"                                                                                                                                                 
[17210] "Gynecologic_Oncologist"                                                                                                                                               
[17211] "Hematologist"                                                                                                                                                         
[17212] "Internist"                                                                                                                                                            
[17213] "Radiation_Oncologist"                                                                                                                                                 
[17214] "Radiation_Therapist"                                                                                                                                                  
[17215] "Eye_Surgeon"                                                                                                                                                          
[17216] "Thoracic_Surgeon"                                                                                                                                                     
[17217] "Oncology"                                                                                                                                                             
[17218] "Medical_Oncologist"                                                                                                                                                   
[17219] "Surgical_Oncology"                                                                                                                                                    
[17220] "Surgical_Oncologist"                                                                                                                                                  
[17221] "Oncologic_Surgeon"                                                                                                                                                    
[17222] "Urologic_Surgeon"                                                                                                                                                     
[17223] "Epidemiologist"                                                                                                                                                       
[17224] "Pediatric_Hematology_Oncology"                                                                                                                                        
[17225] "Hematologist_Oncologist_Pediatric"                                                                                                                                    
[17226] "Performance_Status_2"                                                                                                                                                 
[17227] "Performance_Status_3"                                                                                                                                                 
[17228] "Performance_Status_4"                                                                                                                                                 
[17229] "History_of_Myocardial_Infarction_Within_6_Months"                                                                                                                     
[17230] "Head_and_Neck_Surgeon"                                                                                                                                                
[17231] "Pediatric_Surgery"                                                                                                                                                    
[17232] "Pediatric_Oncology"                                                                                                                                                   
[17233] "Pediatric_Oncologist"                                                                                                                                                 
[17234] "Neurologic_Oncology"                                                                                                                                                  
[17235] "Pediatric_Neurology"                                                                                                                                                  
[17236] "Dermatologic_Oncology"                                                                                                                                                
[17237] "Plastic_Surgeon"                                                                                                                                                      
[17238] "Pediatric_Neurology_Oncology"                                                                                                                                         
[17239] "Pediatric_Neurologist_Oncologist"                                                                                                                                     
[17240] "Colon_and_Rectal_Surgeon"                                                                                                                                             
[17241] "Pediatric_Radiology"                                                                                                                                                  
[17242] "Pediatric_Radiologist"                                                                                                                                                
[17243] "Endocrinology_and_Metabolism"                                                                                                                                         
[17244] "Hematology_Board_Certification"                                                                                                                                       
[17245] "Medical_Oncology_Board_Certification"                                                                                                                                 
[17246] "Gynecologic_Oncology_Board_Certification"                                                                                                                             
[17247] "Therapeutic_Radiology_Board_Certification"                                                                                                                            
[17248] "Pediatric_Hematology-Oncology_Board_Certification"                                                                                                                    
[17249] "Assessment_of_Gonadal_Function"                                                                                                                                       
[17250] "Metabolic_Abnormality_Assessment"                                                                                                                                     
[17251] "Psychosocial_Effects_Treatment"                                                                                                                                       
[17252] "Educational_Intervention"                                                                                                                                             
[17253] "Methotrexate-E_Therapeutic_Implant"                                                                                                                                   
[17254] "Fluorouracil-E_Therapeutic_Implant"                                                                                                                                   
[17255] "Melan-A"                                                                                                                                                              
[17256] "Cisplatin-E_Therapeutic_Implant"                                                                                                                                      
[17257] "Federated_States_of_Micronesia"                                                                                                                                       
[17258] "Northern_Mariana_Islands"                                                                                                                                             
[17259] "Palliative_Surgery"                                                                                                                                                   
[17260] "Aruba"                                                                                                                                                                
[17261] "Saint_Kitts_and_Nevis"                                                                                                                                                
[17262] "Meta-Analysis"                                                                                                                                                        
[17263] "Cultural_Diversity"                                                                                                                                                   
[17264] "Heat-Shock_Response"                                                                                                                                                  
[17265] "Mucosal_Immunity"                                                                                                                                                     
[17266] "DNA_Footprinting"                                                                                                                                                     
[17267] "CD56_Antigen"                                                                                                                                                         
[17268] "Imaging_Phantoms"                                                                                                                                                     
[17269] "SRC_Family_Tyrosine_Kinase"                                                                                                                                           
[17270] "Cell_Respiration"                                                                                                                                                     
[17271] "Cell_Lineage"                                                                                                                                                         
[17272] "HT-29"                                                                                                                                                                
[17273] "Selectin"                                                                                                                                                             
[17274] "Blocking_Antibody"                                                                                                                                                    
[17275] "p59-HCK"                                                                                                                                                              
[17276] "CCAAT_Enhancer_Binding_Protein_Epsilon"                                                                                                                               
[17277] "Cyclin-Dependent_Kinase_Inhibitor-1B"                                                                                                                                 
[17278] "Furin_Preproprotein"                                                                                                                                                  
[17279] "NF-AT"                                                                                                                                                                
[17280] "Ewing_Sarcoma_Breakpoint_Region-1_Protein"                                                                                                                            
[17281] "ELK3_Protein"                                                                                                                                                         
[17282] "BHLH_Protein"                                                                                                                                                         
[17283] "TRADD_Protein"                                                                                                                                                        
[17284] "DCC_Protein"                                                                                                                                                          
[17285] "Tissue_Polypeptide_Specific_Antigen"                                                                                                                                  
[17286] "Angiostatin"                                                                                                                                                          
[17287] "Polo-Like_Kinase"                                                                                                                                                     
[17288] "Tumor_Protein_p53-Binding_Protein-2"                                                                                                                                  
[17289] "Tuberin"                                                                                                                                                              
[17290] "RecQL_Helicase"                                                                                                                                                       
[17291] "hSNF5-INI1_Protein"                                                                                                                                                   
[17292] "BRCA2_Protein"                                                                                                                                                        
[17293] "Eukaryotic_Translation_Initiation_Factor_3_Subunit-6"                                                                                                                 
[17294] "Zinc_Finger_Protein-145"                                                                                                                                              
[17295] "WNT7A_Protein"                                                                                                                                                        
[17296] "CD166_Antigen"                                                                                                                                                        
[17297] "VAV2_Protein"                                                                                                                                                         
[17298] "Somatostatin_Receptor-2"                                                                                                                                              
[17299] "Receptor-Interacting_Serine-Threonine_Kinase-1"                                                                                                                       
[17300] "Ataxia_Telangiectasia_Mutated_Protein"                                                                                                                                
[17301] "Interferon_Regulatory_Factor-4"                                                                                                                                       
[17302] "Somatostatin_Receptor-5"                                                                                                                                              
[17303] "Centromere_Protein-F"                                                                                                                                                 
[17304] "RIP140_Protein"                                                                                                                                                       
[17305] "Immune_Response"                                                                                                                                                      
[17306] "Antibody-Mediated_Lympholysis"                                                                                                                                        
[17307] "Angiogenesis"                                                                                                                                                         
[17308] "Carbohydrate_Metabolism"                                                                                                                                              
[17309] "Tobacco_Smoking"                                                                                                                                                      
[17310] "Therapeutic_Agents"                                                                                                                                                   
[17311] "Quinone_Oxidoreductase"                                                                                                                                               
[17312] "Immune_Function"                                                                                                                                                      
[17313] "Genetic"                                                                                                                                                              
[17314] "Genetic_Susceptibility"                                                                                                                                               
[17315] "Microbial_Genetics"                                                                                                                                                   
[17316] "Exposure"                                                                                                                                                             
[17317] "Gleason_Score"                                                                                                                                                        
[17318] "Morphology"                                                                                                                                                           
[17319] "Contracting"                                                                                                                                                          
[17320] "Atypical_Regeneration"                                                                                                                                                
[17321] "Community_Physician"                                                                                                                                                  
[17322] "Prosthodontist"                                                                                                                                                       
[17323] "Therapeutic_Implant"                                                                                                                                                  
[17324] "Cigarette_Smoker"                                                                                                                                                     
[17325] "Ashkenazi_Jew"                                                                                                                                                        
[17326] "MAGEA3_Gene"                                                                                                                                                          
[17327] "Interventional_Radiology"                                                                                                                                             
[17328] "Education_Level"                                                                                                                                                      
[17329] "Falkland_Islands"                                                                                                                                                     
[17330] "Nicotine_Patch"                                                                                                                                                       
[17331] "Aromatase_Cytochrome-P450"                                                                                                                                            
[17332] "Foreign_Component"                                                                                                                                                    
[17333] "Functional_Magnetic_Resonance_Imaging"                                                                                                                                
[17334] "Rehabilitation_Nursing"                                                                                                                                               
[17335] "Hypermedia"                                                                                                                                                           
[17336] "DNA_Methylation"                                                                                                                                                      
[17337] "Multimedia"                                                                                                                                                           
[17338] "BCL2_Gene"                                                                                                                                                            
[17339] "Bioinformatics"                                                                                                                                                       
[17340] "BRCA1_Gene"                                                                                                                                                           
[17341] "ABCB1_Gene"                                                                                                                                                           
[17342] "Multidrug_Resistance_Gene"                                                                                                                                            
[17343] "COS-1"                                                                                                                                                                
[17344] "Ku80_Protein"                                                                                                                                                         
[17345] "AP-2_Beta_Protein"                                                                                                                                                    
[17346] "Caveolin-1"                                                                                                                                                           
[17347] "ERCC6_Protein"                                                                                                                                                        
[17348] "LMO2_Gene"                                                                                                                                                            
[17349] "Rhombotin-2"                                                                                                                                                          
[17350] "Vascular_Endothelial_Growth_Factor_Receptor-1"                                                                                                                        
[17351] "Rho_Guanine_Nucleotide_Exchange_Factor-5"                                                                                                                             
[17352] "Nuclear_Receptor_Coactivator-1"                                                                                                                                       
[17353] "PTK2B_Protein_Tyrosine_Kinase-2_Beta"                                                                                                                                 
[17354] "Epithelial_Membrane_Protein-1"                                                                                                                                        
[17355] "Bloom_Syndrome_Protein"                                                                                                                                               
[17356] "Cyclin-B1"                                                                                                                                                            
[17357] "Mothers_Against_Decapentaplegic_Homolog-4_Protein"                                                                                                                    
[17358] "G-s_Alpha"                                                                                                                                                            
[17359] "Prostaglandin-Endoperoxide_Synthase-2"                                                                                                                                
[17360] "CKR5"                                                                                                                                                                 
[17361] "Metalloprotease-RGD-Disintegrin_Protein"                                                                                                                              
[17362] "Somatostatin_Receptor-4"                                                                                                                                              
[17363] "Cyclin-D1"                                                                                                                                                            
[17364] "Adenovirus_Death_Protein"                                                                                                                                             
[17365] "p300_CBP-Associated_Factor"                                                                                                                                           
[17366] "Spermidine-Spermine_N1-Acetyltransferase"                                                                                                                             
[17367] "Cell_Biology"                                                                                                                                                         
[17368] "Nutritional_Status"                                                                                                                                                   
[17369] "Dietary_History"                                                                                                                                                      
[17370] "Light_Microscopy"                                                                                                                                                     
[17371] "Cell-Mediated_Immunity_Multitest"                                                                                                                                     
[17372] "Immune"                                                                                                                                                               
[17373] "Unknown"                                                                                                                                                              
[17374] "Scan"                                                                                                                                                                 
[17375] "Histopathologic_Grade"                                                                                                                                                
[17376] "Digital_X-Ray"                                                                                                                                                        
[17377] "Home"                                                                                                                                                                 
[17378] "Vital"                                                                                                                                                                
[17379] "Staging_System"                                                                                                                                                       
[17380] "_3-Dimensional"                                                                                                                                                       
[17381] "ST7_Gene"                                                                                                                                                             
[17382] "Antarctica"                                                                                                                                                           
[17383] "TNM_Ovary_Neoplasm_Staging"                                                                                                                                           
[17384] "Tumor_Tissue"                                                                                                                                                         
[17385] "Roller_Bottle"                                                                                                                                                        
[17386] "Immunology"                                                                                                                                                           
[17387] "Carcinogen_Effect_in_Offspring"                                                                                                                                       
[17388] "Megakaryopoiesis"                                                                                                                                                     
[17389] "Fecal_Occult_Blood_Test"                                                                                                                                              
[17390] "Prostatic_Acid_Phosphatase"                                                                                                                                           
[17391] "Loss_of_Heterozygosity"                                                                                                                                               
[17392] "T-Cell_Receptor_Gene"                                                                                                                                                 
[17393] "Chemokine_Receptor"                                                                                                                                                   
[17394] "Leukopoiesis"                                                                                                                                                         
[17395] "Diagnostic_Procedure"                                                                                                                                                 
[17396] "CCND1_Gene"                                                                                                                                                           
[17397] "CDKN2A_Gene"                                                                                                                                                          
[17398] "DNA_Polymerase_Beta"                                                                                                                                                  
[17399] "Cytochrome-P450-2A5"                                                                                                                                                  
[17400] "Ap3A-Hydrolase"                                                                                                                                                       
[17401] "FPS-FES-Related_Tyrosine_Kinase"                                                                                                                                      
[17402] "Core-Binding_Factor_Beta_Subunit"                                                                                                                                     
[17403] "Telomeric_Repeat_Binding_Factor-1"                                                                                                                                    
[17404] "Vascular_Endothelial_Growth_Factor_Receptor_3"                                                                                                                        
[17405] "Non-Receptor_Type_11_Protein_Tyrosine_Phosphatase"                                                                                                                    
[17406] "Caspase-3"                                                                                                                                                            
[17407] "hHLTF_Protein"                                                                                                                                                        
[17408] "HKR3_Protein"                                                                                                                                                         
[17409] "Mothers_Against_Decapentaplegic_Homolog-3_Protein"                                                                                                                    
[17410] "Somatostatin_Receptor-1"                                                                                                                                              
[17411] "PU-1_Transcription_Factor"                                                                                                                                            
[17412] "Exostosin-2"                                                                                                                                                          
[17413] "Thrombospondin-2"                                                                                                                                                     
[17414] "Cytokeratin-19_Fragment-21-1_Peptide"                                                                                                                                 
[17415] "TEL-AML1_Fusion_Protein"                                                                                                                                              
[17416] "Thymosin_Beta-15"                                                                                                                                                     
[17417] "Angiopoietin-1"                                                                                                                                                       
[17418] "Somatostatin_Receptor-3"                                                                                                                                              
[17419] "CDC6_Cell_Division_Cycle-6_Homolog_Protein"                                                                                                                           
[17420] "Caspase-1"                                                                                                                                                            
[17421] "Endostatin"                                                                                                                                                           
[17422] "MAFG_Protein"                                                                                                                                                         
[17423] "GLI2_Protein"                                                                                                                                                         
[17424] "Glutathione_S-Transferase-Pi"                                                                                                                                         
[17425] "Exostosin-1"                                                                                                                                                          
[17426] "Menin"                                                                                                                                                                
[17427] "ESX_Protein"                                                                                                                                                          
[17428] "LY-49"                                                                                                                                                                
[17429] "Notch4_Protein"                                                                                                                                                       
[17430] "Checkpoint_Suppressor-1_Protein"                                                                                                                                      
[17431] "Angiopoietin-2"                                                                                                                                                       
[17432] "Environmental_Carcinogenesis"                                                                                                                                         
[17433] "Partial_Remission"                                                                                                                                                    
[17434] "Tobacco_Use"                                                                                                                                                          
[17435] "Somatic_Mutation"                                                                                                                                                     
[17436] "Blast_Cell_Proliferation"                                                                                                                                             
[17437] "Human_Anti-Mouse_Antibody"                                                                                                                                            
[17438] "Gray"                                                                                                                                                                 
[17439] "Rad"                                                                                                                                                                  
[17440] "Oncology_Nurse"                                                                                                                                                       
[17441] "Supermarkets"                                                                                                                                                         
[17442] "Inner_City"                                                                                                                                                           
[17443] "Radiation_Dose_Unit"                                                                                                                                                  
[17444] "Church"                                                                                                                                                               
[17445] "Neutron_Radiation"                                                                                                                                                    
[17446] "Surgeon"                                                                                                                                                              
[17447] "Enzyme_Inhibitor_Protein"                                                                                                                                             
[17448] "Structural_Protein"                                                                                                                                                   
[17449] "Training_and_Education"                                                                                                                                               
[17450] "Tissue_Engineering"                                                                                                                                                   
[17451] "Bioengineering"                                                                                                                                                       
[17452] "Cancer_Risk"                                                                                                                                                          
[17453] "Carcinogenesis"                                                                                                                                                       
[17454] "Cardiovascular_Pharmacology"                                                                                                                                          
[17455] "Cell_Growth_Regulation"                                                                                                                                               
[17456] "Cell_Proliferation"                                                                                                                                                   
[17457] "Cellular_Oncology"                                                                                                                                                    
[17458] "Chemical_Carcinogenesis"                                                                                                                                              
[17459] "Comparative_Genomic_Analysis"                                                                                                                                         
[17460] "Data_Management"                                                                                                                                                      
[17461] "Developmental_Genetics"                                                                                                                                               
[17462] "Developmental_Neurobiology"                                                                                                                                           
[17463] "Environmental_Engineering"                                                                                                                                            
[17464] "FOS_Family_Protein"                                                                                                                                                   
[17465] "Gel_Electrophoresis"                                                                                                                                                  
[17466] "Gene-Environment_Interaction"                                                                                                                                         
[17467] "Gene_Mutation"                                                                                                                                                        
[17468] "Immunopathology"                                                                                                                                                      
[17469] "Immunoregulation"                                                                                                                                                     
[17470] "MCF7"                                                                                                                                                                 
[17471] "Molecular_Dynamics"                                                                                                                                                   
[17472] "Molecular_Pathology"                                                                                                                                                  
[17473] "Molecular_Psychobiology"                                                                                                                                              
[17474] "Myogenesis"                                                                                                                                                           
[17475] "Special_Population"                                                                                                                                                   
[17476] "Physical_Phenomena_or_Properties"                                                                                                                                     
[17477] "Protein_Synthesis"                                                                                                                                                    
[17478] "Protein_Degradation"                                                                                                                                                  
[17479] "Proteolysis"                                                                                                                                                          
[17480] "Receptor"                                                                                                                                                             
[17481] "Receptor_Mediated_Endocytosis"                                                                                                                                        
[17482] "Steroid_Hormone_Receptor"                                                                                                                                             
[17483] "Steroid_Metabolism"                                                                                                                                                   
[17484] "Stoichiometry"                                                                                                                                                        
[17485] "Structural_Biology"                                                                                                                                                   
[17486] "Protein_Trafficking"                                                                                                                                                  
[17487] "Cryo-Electron_Microscopy"                                                                                                                                             
[17488] "Representational_Difference_Analysis"                                                                                                                                 
[17489] "B-Cell_CLL_Lymphoma-2"                                                                                                                                                
[17490] "Enhancer_Binding_Protein"                                                                                                                                             
[17491] "Surface_Plasmon_Resonance"                                                                                                                                            
[17492] "Research_Facilities"                                                                                                                                                  
[17493] "Biophysical_Chemistry"                                                                                                                                                
[17494] "BRCA2_Gene"                                                                                                                                                           
[17495] "Tumorigenesis"                                                                                                                                                        
[17496] "Chemical_Kinetics"                                                                                                                                                    
[17497] "Cryobiology"                                                                                                                                                          
[17498] "Microdissection"                                                                                                                                                      
[17499] "DNA_Synthesis"                                                                                                                                                        
[17500] "Lipophilicity"                                                                                                                                                        
[17501] "RNA_Transport"                                                                                                                                                        
[17502] "Leukemogenesis"                                                                                                                                                       
[17503] "Tumor_Initiation"                                                                                                                                                     
[17504] "Neural_Prosthesis"                                                                                                                                                    
[17505] "Neuroimmunology"                                                                                                                                                      
[17506] "Parallel_Computing"                                                                                                                                                   
[17507] "Missense_Mutation"                                                                                                                                                    
[17508] "Transition_Mutation"                                                                                                                                                  
[17509] "Transversion_Mutation"                                                                                                                                                
[17510] "RT-PCR"                                                                                                                                                               
[17511] "Protein_Renaturation"                                                                                                                                                 
[17512] "Radiolabeled"                                                                                                                                                         
[17513] "ERG_Gene"                                                                                                                                                             
[17514] "Yeast_One_Two-Hybrid_System"                                                                                                                                          
[17515] "Computer_Sciences"                                                                                                                                                    
[17516] "Tandem_Mass_Spectrometry"                                                                                                                                             
[17517] "Gene_Knockout"                                                                                                                                                        
[17518] "Homologous_Recombination"                                                                                                                                             
[17519] "Informatics"                                                                                                                                                          
[17520] "Intracellular_Transport"                                                                                                                                              
[17521] "Intracellular_Protein_Transport"                                                                                                                                      
[17522] "Molecular_Modeling"                                                                                                                                                   
[17523] "High_Performance_Computing"                                                                                                                                           
[17524] "Sodium_Dodecylsulfate-Polyacrylamide_Gel_Electrophoresis"                                                                                                             
[17525] "Diaphanography"                                                                                                                                                       
[17526] "Threonine-Tyrosine_Protein_Kinase"                                                                                                                                    
[17527] "Caspase"                                                                                                                                                              
[17528] "Chromosome_Painting"                                                                                                                                                  
[17529] "Expressed_Sequence_Tag"                                                                                                                                               
[17530] "Graft-vs-Leukemia_Effect"                                                                                                                                             
[17531] "Distance_Learning"                                                                                                                                                    
[17532] "DNA_Microarray_Chip"                                                                                                                                                  
[17533] "Journalism"                                                                                                                                                           
[17534] "Manuscripts"                                                                                                                                                          
[17535] "eIF2B"                                                                                                                                                                
[17536] "Glandular_Kallikrein-2_Precursor"                                                                                                                                     
[17537] "Matrix_Metalloproteinase"                                                                                                                                             
[17538] "Neuregulin-1_Protein"                                                                                                                                                 
[17539] "RGS_Family_Protein"                                                                                                                                                   
[17540] "B-Cell_CLL_Lymphoma-3"                                                                                                                                                
[17541] "ID2_Protein"                                                                                                                                                          
[17542] "Spleen_Tyrosine_Kinase"                                                                                                                                               
[17543] "MAF_Protein"                                                                                                                                                          
[17544] "GLI_Protein"                                                                                                                                                          
[17545] "Nuclear_Receptor_Coactivator-3"                                                                                                                                       
[17546] "TERT_Gene"                                                                                                                                                            
[17547] "TRAIL_Receptor-1"                                                                                                                                                     
[17548] "Neuregulin-2_Protein"                                                                                                                                                 
[17549] "Hamartin"                                                                                                                                                             
[17550] "Axin-1_Protein"                                                                                                                                                       
[17551] "TRAIL_Receptor-2"                                                                                                                                                     
[17552] "Survivin"                                                                                                                                                             
[17553] "Neuregulin-3_Protein"                                                                                                                                                 
[17554] "PTEN_Tyrosine_Phosphatase"                                                                                                                                            
[17555] "Caspase-8"                                                                                                                                                            
[17556] "Serine-Threonine_Protein_Kinase-11"                                                                                                                                   
[17557] "Histone_Acetyltransferase-1"                                                                                                                                          
[17558] "TAF-172"                                                                                                                                                              
[17559] "Hepatocyte_Growth_Factor_Receptor"                                                                                                                                    
[17560] "DDX6_Protein"                                                                                                                                                         
[17561] "Stereochemistry"                                                                                                                                                      
[17562] "Pathology"                                                                                                                                                            
[17563] "Histopathology"                                                                                                                                                       
[17564] "Computer_Analysis"                                                                                                                                                    
[17565] "Plastic_Surgery"                                                                                                                                                      
[17566] "Immunological_Diagnostic_Methods"                                                                                                                                     
[17567] "Molecular_Diagnostic_Methods"                                                                                                                                         
[17568] "Medical_Genetics_Board_Certification"                                                                                                                                 
[17569] "Genetic_Counseling_Board_Certification"                                                                                                                               
[17570] "Clinical_Genetics_Board_Certification"                                                                                                                                
[17571] "Clinical_Biochemical_Genetics_Board_Certification"                                                                                                                    
[17572] "Clinical_Molecular_Genetics_Board_Certification"                                                                                                                      
[17573] "Clinical_Cytogenetics_Board_Certification"                                                                                                                            
[17574] "Antiangiogenesis"                                                                                                                                                     
[17575] "Biopsy_Specimen"                                                                                                                                                      
[17576] "Brief_Pain_Inventory"                                                                                                                                                 
[17577] "Compression_Bandage"                                                                                                                                                  
[17578] "Clinical_Trials_Cooperative_Group"                                                                                                                                    
[17579] "Distant_Metastasis"                                                                                                                                                   
[17580] "Liposome"                                                                                                                                                             
[17581] "Lymph_Node_Drainage"                                                                                                                                                  
[17582] "Lymph_Node_Mapping"                                                                                                                                                   
[17583] "Protein_Overexpression"                                                                                                                                               
[17584] "Partial_Response"                                                                                                                                                     
[17585] "Stable_Disease"                                                                                                                                                       
[17586] "Whitmore-Jewett_Staging_System"                                                                                                                                       
[17587] "Chemosensitivity_Assay"                                                                                                                                               
[17588] "Transmission_Electron_Microscopy"                                                                                                                                     
[17589] "Potential_Energy"                                                                                                                                                     
[17590] "Free_Energy"                                                                                                                                                          
[17591] "Molecular_Interaction"                                                                                                                                                
[17592] "Human_Biology"                                                                                                                                                        
[17593] "Ethanol_Metabolism"                                                                                                                                                   
[17594] "Pharmacology_and_Toxicology"                                                                                                                                          
[17595] "Therapeutic_Index"                                                                                                                                                    
[17596] "Endocrine_Physiology"                                                                                                                                                 
[17597] "Phenocopy"                                                                                                                                                            
[17598] "Disease_Outcome"                                                                                                                                                      
[17599] "Media_Campaign"                                                                                                                                                       
[17600] "Treatment_Factors"                                                                                                                                                    
[17601] "Health_Information_System"                                                                                                                                            
[17602] "Social_Group"                                                                                                                                                         
[17603] "Communication_Methods"                                                                                                                                                
[17604] "Glossary"                                                                                                                                                             
[17605] "Program_Announcements"                                                                                                                                                
[17606] "Geographic_Distribution"                                                                                                                                              
[17607] "Time_Series_Analysis"                                                                                                                                                 
[17608] "Ethnic_Origin"                                                                                                                                                        
[17609] "Alaska_Native"                                                                                                                                                        
[17610] "Economically_Deprived"                                                                                                                                                
[17611] "G_Protein-Coupled_Receptor"                                                                                                                                           
[17612] "Academia"                                                                                                                                                             
[17613] "General_Population"                                                                                                                                                   
[17614] "Column_Chromatography"                                                                                                                                                
[17615] "Regression"                                                                                                                                                           
[17616] "Environmental_Risk_Factor"                                                                                                                                            
[17617] "Organization_Charts"                                                                                                                                                  
[17618] "Remission"                                                                                                                                                            
[17619] "Cancer_Genetics"                                                                                                                                                      
[17620] "Oncogene_MET"                                                                                                                                                         
[17621] "CDH1_Gene"                                                                                                                                                            
[17622] "CDK4_Gene"                                                                                                                                                            
[17623] "EXT1_Gene"                                                                                                                                                            
[17624] "EXT2_Gene"                                                                                                                                                            
[17625] "STK11_Gene"                                                                                                                                                           
[17626] "MEN1_Gene"                                                                                                                                                            
[17627] "PTCH_Gene"                                                                                                                                                            
[17628] "PTEN_Gene"                                                                                                                                                            
[17629] "RET_Gene"                                                                                                                                                             
[17630] "MADH4_Gene"                                                                                                                                                           
[17631] "TSC1_Gene"                                                                                                                                                            
[17632] "TSC2_Gene"                                                                                                                                                            
[17633] "VHL_Gene"                                                                                                                                                             
[17634] "WT1_Gene"                                                                                                                                                             
[17635] "WT2_Gene"                                                                                                                                                             
[17636] "Pathogenesis"                                                                                                                                                         
[17637] "Relapse"                                                                                                                                                              
[17638] "Catabolism"                                                                                                                                                           
[17639] "Cathepsin-B"                                                                                                                                                          
[17640] "Community_Health"                                                                                                                                                     
[17641] "Manpower"                                                                                                                                                             
[17642] "Cigarette_Smoking"                                                                                                                                                    
[17643] "Tyrosinase-Related_Protein-1"                                                                                                                                         
[17644] "Substance_Abuse"                                                                                                                                                      
[17645] "Cardiovascular_Pathology"                                                                                                                                             
[17646] "Isotropy"                                                                                                                                                             
[17647] "Pulmonary_Pathology"                                                                                                                                                  
[17648] "Proteome"                                                                                                                                                             
[17649] "Small_G_Protein"                                                                                                                                                      
[17650] "PDGFB_Gene"                                                                                                                                                           
[17651] "Single_Nucleotide_Polymorphism"                                                                                                                                       
[17652] "Cytogenetic_Analysis"                                                                                                                                                 
[17653] "Heterotrimeric_G_Protein"                                                                                                                                             
[17654] "AP-2_Gamma_Protein"                                                                                                                                                   
[17655] "VAV1_Protein"                                                                                                                                                         
[17656] "ST5_Protein"                                                                                                                                                          
[17657] "Nuclear_Receptor_Co-Repressor-1"                                                                                                                                      
[17658] "Peroxisome_Proliferator-Activated_Receptor_Binding_Protein"                                                                                                           
[17659] "Caspase-10"                                                                                                                                                           
[17660] "ELK-1_Protein"                                                                                                                                                        
[17661] "VEG_Inhibitor"                                                                                                                                                        
[17662] "Glutathione_S-Transferase-M1"                                                                                                                                         
[17663] "RALA_Protein"                                                                                                                                                         
[17664] "PLZF-RARalpha"                                                                                                                                                        
[17665] "RALB_Protein"                                                                                                                                                         
[17666] "Histone_Deacetylase-2"                                                                                                                                                
[17667] "Matriptase"                                                                                                                                                           
[17668] "Pancreatic_Enzyme"                                                                                                                                                    
[17669] "X-Ray_Cross_Complementing_Group"                                                                                                                                      
[17670] "Hepatitis-B_Antigen_Peptide"                                                                                                                                          
[17671] "Polymorphic_Microsatellite_Marker"                                                                                                                                    
[17672] "DNA_Maintenance"                                                                                                                                                      
[17673] "TAL1_Gene"                                                                                                                                                            
[17674] "Mutation_Analysis"                                                                                                                                                    
[17675] "DNA_Ploidy_Analysis"                                                                                                                                                  
[17676] "Clonality"                                                                                                                                                            
[17677] "HUMARA_Assay"                                                                                                                                                         
[17678] "Videothoracoscopy"                                                                                                                                                    
[17679] "Tumor_Replication_Error_Analysis"                                                                                                                                     
[17680] "Fc-Gamma_Receptor-II"                                                                                                                                                 
[17681] "Polymorphism_Analysis"                                                                                                                                                
[17682] "Flu_Matrix_Protein"                                                                                                                                                   
[17683] "NAT2_Gene"                                                                                                                                                            
[17684] "ETV6_Gene"                                                                                                                                                            
[17685] "Hormone_Receptor_Test"                                                                                                                                                
[17686] "Differentiation"                                                                                                                                                      
[17687] "Transrectal_Ultrasound"                                                                                                                                               
[17688] "Xerogram"                                                                                                                                                             
[17689] "Sun_Protection_Factor"                                                                                                                                                
[17690] "RevM10_Gene"                                                                                                                                                          
[17691] "Core-Binding_Factor_Alpha"                                                                                                                                            
[17692] "ETO_Protein"                                                                                                                                                          
[17693] "FLI1_Gene"                                                                                                                                                            
[17694] "EWSR1_Gene"                                                                                                                                                           
[17695] "CDKN2B_Gene"                                                                                                                                                          
[17696] "BAX_Gene"                                                                                                                                                             
[17697] "C-MET_Gene"                                                                                                                                                           
[17698] "ETS_Family_Gene"                                                                                                                                                      
[17699] "ETS1_Gene"                                                                                                                                                            
[17700] "ETS2_Gene"                                                                                                                                                            
[17701] "Disease_Marker"                                                                                                                                                       
[17702] "NME1_Gene"                                                                                                                                                            
[17703] "Oncogene_AP2"                                                                                                                                                         
[17704] "Oncogene_B-LYM"                                                                                                                                                       
[17705] "Oncogene_FGR"                                                                                                                                                         
[17706] "Oncogene_LCK"                                                                                                                                                         
[17707] "Oncogene_DBL"                                                                                                                                                         
[17708] "MEL_Gene"                                                                                                                                                             
[17709] "PIM1_Gene"                                                                                                                                                            
[17710] "RAF1_Gene"                                                                                                                                                            
[17711] "Oncogene_ROS"                                                                                                                                                         
[17712] "G-Protein_Oncogene"                                                                                                                                                   
[17713] "Growth_Factor_Oncogene"                                                                                                                                               
[17714] "Nuclear_Protein_Oncogene"                                                                                                                                             
[17715] "Protein-Kinase_Oncogene"                                                                                                                                              
[17716] "Tyrosine-Kinase_Oncogene"                                                                                                                                             
[17717] "MDM2_Gene"                                                                                                                                                            
[17718] "NOTCH4_Gene"                                                                                                                                                          
[17719] "EIF3S6_Gene"                                                                                                                                                          
[17720] "Oncogene_KIT"                                                                                                                                                         
[17721] "Oncogene_YES-1"                                                                                                                                                       
[17722] "AKT1_Gene"                                                                                                                                                            
[17723] "WNT5A_Gene"                                                                                                                                                           
[17724] "AKT2_Gene"                                                                                                                                                            
[17725] "WNT2_Gene"                                                                                                                                                            
[17726] "ARAF1_Gene"                                                                                                                                                           
[17727] "WNT1_Gene"                                                                                                                                                            
[17728] "ARHA_Gene"                                                                                                                                                            
[17729] "ARHB_Gene"                                                                                                                                                            
[17730] "ARHC_Gene"                                                                                                                                                            
[17731] "AXL_Gene"                                                                                                                                                             
[17732] "BCL3_Gene"                                                                                                                                                            
[17733] "VAV2_Gene"                                                                                                                                                            
[17734] "BMI1_Gene"                                                                                                                                                            
[17735] "BRAF_Gene"                                                                                                                                                            
[17736] "CBL_Gene"                                                                                                                                                             
[17737] "VAV1_Gene"                                                                                                                                                            
[17738] "TP73_Gene"                                                                                                                                                            
[17739] "TP53BP2_Gene"                                                                                                                                                         
[17740] "TNF_Gene"                                                                                                                                                             
[17741] "Oncogene_TIM"                                                                                                                                                         
[17742] "TIAM1_Gene"                                                                                                                                                           
[17743] "CDKN1C_Gene"                                                                                                                                                          
[17744] "CHES1_Gene"                                                                                                                                                           
[17745] "MAP3K8_Gene"                                                                                                                                                          
[17746] "CRK_Gene"                                                                                                                                                             
[17747] "CRKL_Gene"                                                                                                                                                            
[17748] "D10S170"                                                                                                                                                              
[17749] "THRB_Gene"                                                                                                                                                            
[17750] "DDX6_Gene"                                                                                                                                                            
[17751] "E2F1_Gene"                                                                                                                                                            
[17752] "THRA_Gene"                                                                                                                                                            
[17753] "NCOA4_Gene"                                                                                                                                                           
[17754] "EMS1_Gene"                                                                                                                                                            
[17755] "EPHA1_Gene"                                                                                                                                                           
[17756] "EPHA3_Gene"                                                                                                                                                           
[17757] "NR2F6_Gene"                                                                                                                                                           
[17758] "ERBB3_Gene"                                                                                                                                                           
[17759] "SUPT3H_Gene"                                                                                                                                                          
[17760] "ERBB4_Gene"                                                                                                                                                           
[17761] "SUPT5H_Gene"                                                                                                                                                          
[17762] "SUPT6H_Gene"                                                                                                                                                          
[17763] "ETV3_Gene"                                                                                                                                                            
[17764] "EVI1_Gene"                                                                                                                                                            
[17765] "Oncogene_SPI1"                                                                                                                                                        
[17766] "SMARCB1_Gene"                                                                                                                                                         
[17767] "Proliferation_Marker"                                                                                                                                                 
[17768] "Metastasis_and_Aggressiveness_Marker"                                                                                                                                 
[17769] "FAT_Gene"                                                                                                                                                             
[17770] "ERBB5_Receptor_Protein_Tyrosine_Kinase"                                                                                                                               
[17771] "ROS1_Gene"                                                                                                                                                            
[17772] "CSVTCG-Specific_TSP-1_Receptor"                                                                                                                                       
[17773] "RALB_Gene"                                                                                                                                                            
[17774] "RALA_Gene"                                                                                                                                                            
[17775] "PVT1_Gene"                                                                                                                                                            
[17776] "NFKB2_Gene"                                                                                                                                                           
[17777] "NMYC_Gene"                                                                                                                                                            
[17778] "FER_Gene"                                                                                                                                                             
[17779] "LMYC_Gene"                                                                                                                                                            
[17780] "FGF3_Gene"                                                                                                                                                            
[17781] "MYBL2_Gene"                                                                                                                                                           
[17782] "MYBL1_Gene"                                                                                                                                                           
[17783] "MPL_Gene"                                                                                                                                                             
[17784] "FGF6_Gene"                                                                                                                                                            
[17785] "FOXG1B_Gene"                                                                                                                                                          
[17786] "FLT1_Gene"                                                                                                                                                            
[17787] "FOSL1_Gene"                                                                                                                                                           
[17788] "MAFG_Gene"                                                                                                                                                            
[17789] "MAF_Gene"                                                                                                                                                             
[17790] "FOSL2_Gene"                                                                                                                                                           
[17791] "FYN_Gene"                                                                                                                                                             
[17792] "GLI1_Gene"                                                                                                                                                            
[17793] "TACSTD1_Gene"                                                                                                                                                         
[17794] "GLI2_Gene"                                                                                                                                                            
[17795] "LYN_Gene"                                                                                                                                                             
[17796] "LTA_Gene"                                                                                                                                                             
[17797] "LTB_Gene"                                                                                                                                                             
[17798] "CXCL2_Gene"                                                                                                                                                           
[17799] "CXCL3_Gene"                                                                                                                                                           
[17800] "JUND_Gene"                                                                                                                                                            
[17801] "JUNB_Gene"                                                                                                                                                            
[17802] "IRF4_Gene"                                                                                                                                                            
[17803] "Oncogene_Transcription_Factor"                                                                                                                                        
[17804] "HKR3_Gene"                                                                                                                                                            
[17805] "HCK_Gene"                                                                                                                                                             
[17806] "Topoisomerase-II"                                                                                                                                                     
[17807] "Soluble_ERBB-2_Protein"                                                                                                                                               
[17808] "Soluble_ERBB-1_Protein"                                                                                                                                               
[17809] "G_Protein_Gene"                                                                                                                                                       
[17810] "Proto-Oncogene_Growth_Factor"                                                                                                                                         
[17811] "Proto-Oncogene_Nuclear_Protein"                                                                                                                                       
[17812] "Proto-Oncogene_Transcription_Factor"                                                                                                                                  
[17813] "Proto-Oncogene_Protein-Kinase"                                                                                                                                        
[17814] "Proto-Oncogene_Tyrosine-Kinase"                                                                                                                                       
[17815] "Oncogene_LMYC"                                                                                                                                                        
[17816] "Oncogene_NMYC"                                                                                                                                                        
[17817] "MAS1_Gene"                                                                                                                                                            
[17818] "ELK3_Gene"                                                                                                                                                            
[17819] "ST5_Gene"                                                                                                                                                             
[17820] "SPINK1_Gene"                                                                                                                                                          
[17821] "Oncogene_SKI"                                                                                                                                                         
[17822] "Oncogene_ETS"                                                                                                                                                         
[17823] "ABL2_Gene"                                                                                                                                                            
[17824] "GLI3_Gene"                                                                                                                                                            
[17825] "Oncogene_FPS-FES"                                                                                                                                                     
[17826] "EMP1_Gene"                                                                                                                                                            
[17827] "BCR_Gene"                                                                                                                                                             
[17828] "S-Phase_Fraction"                                                                                                                                                     
[17829] "Oncogene_TRK"                                                                                                                                                         
[17830] "THPO_Gene"                                                                                                                                                            
[17831] "KAI1_Gene"                                                                                                                                                            
[17832] "CXCL1_Gene"                                                                                                                                                           
[17833] "ELK1_Gene"                                                                                                                                                            
[17834] "Oncogene_HST"                                                                                                                                                         
[17835] "NKTR_Gene"                                                                                                                                                            
[17836] "Oncogene_RET"                                                                                                                                                         
[17837] "Research_Ethics"                                                                                                                                                      
[17838] "Regulatory_Protein"                                                                                                                                                   
[17839] "Digital_Mammography"                                                                                                                                                  
[17840] "Virtual_Reality"                                                                                                                                                      
[17841] "Protein-Protein_Interaction"                                                                                                                                          
[17842] "Computational_Chemistry"                                                                                                                                              
[17843] "Genetic_Epidemiology"                                                                                                                                                 
[17844] "High_Throughput_Screening"                                                                                                                                            
[17845] "RNA_Analysis"                                                                                                                                                         
[17846] "Yeast_Protein"                                                                                                                                                        
[17847] "Liquid_Chromatography_Mass_Spectrometry"                                                                                                                              
[17848] "Underserved_Population"                                                                                                                                               
[17849] "Microarray_Analysis"                                                                                                                                                  
[17850] "Nanotechnology"                                                                                                                                                       
[17851] "Neuropathology"                                                                                                                                                       
[17852] "Serial_Analysis_of_Gene_Expression"                                                                                                                                   
[17853] "MSH2_Gene"                                                                                                                                                            
[17854] "MLH1_Gene"                                                                                                                                                            
[17855] "Differential_Display"                                                                                                                                                 
[17856] "Nuclear_Hormone_Receptor_Superfamily"                                                                                                                                 
[17857] "Three_Dimensional_Imaging"                                                                                                                                            
[17858] "Horizontal_Gene_Transfer"                                                                                                                                             
[17859] "Tumor_Necrosis_Factor_Beta_Receptor"                                                                                                                                  
[17860] "TEK_Tyrosine_Kinase"                                                                                                                                                  
[17861] "CD209_Antigen"                                                                                                                                                        
[17862] "ERBB3_Receptor_Protein-Tyrosine_Kinase"                                                                                                                               
[17863] "Cell_Cycle_Kinetics"                                                                                                                                                  
[17864] "Cyclin-Dependent_Kinase_Inhibitor"                                                                                                                                    
[17865] "Risk_Marker"                                                                                                                                                          
[17866] "Oncogene_EGF"                                                                                                                                                         
[17867] "Unclassified_Oncogene"                                                                                                                                                
[17868] "Protein_Phosphorylation"                                                                                                                                              
[17869] "Tyrosine_Phosphorylation"                                                                                                                                             
[17870] "CYP1A1_Gene"                                                                                                                                                          
[17871] "CYP2E1_Gene"                                                                                                                                                          
[17872] "MTHFR_Gene"                                                                                                                                                           
[17873] "NQO1_Gene"                                                                                                                                                            
[17874] "SRD5A2_Gene"                                                                                                                                                          
[17875] "VDR_Gene"                                                                                                                                                             
[17876] "MADH3_Gene"                                                                                                                                                           
[17877] "Short_Tandem_Repeat_Polymorphism"                                                                                                                                     
[17878] "ErbB_Receptor_Family_Protein"                                                                                                                                         
[17879] "ERB_Oncogene_Family"                                                                                                                                                  
[17880] "REL_Protein"                                                                                                                                                          
[17881] "EPH_Tyrosine_Kinase-1"                                                                                                                                                
[17882] "NOV_Gene"                                                                                                                                                             
[17883] "NBL1_Gene"                                                                                                                                                            
[17884] "BCL1_Oncogene"                                                                                                                                                        
[17885] "Nuclear_Grade"                                                                                                                                                        
[17886] "SERPINB5_Gene"                                                                                                                                                        
[17887] "Signaling_Protein"                                                                                                                                                    
[17888] "CSF1R_Gene"                                                                                                                                                           
[17889] "TEL-AML1_Oncogene"                                                                                                                                                    
[17890] "Single_Nucleotide_Polymorphisms_in_Coding_Sequences"                                                                                                                  
[17891] "GSTP1_Gene"                                                                                                                                                           
[17892] "Metabolic_Marker"                                                                                                                                                     
[17893] "Cancer-Predisposing_Gene"                                                                                                                                             
[17894] "Microsatellite_Mutator_Phenotype"                                                                                                                                     
[17895] "RRAD_Gene"                                                                                                                                                            
[17896] "FHIT_Gene"                                                                                                                                                            
[17897] "ABCC1_Gene"                                                                                                                                                           
[17898] "Transcription_Coactivator"                                                                                                                                            
[17899] "Transcription_Repressor_Corepressor"                                                                                                                                  
[17900] "ARHGEF5_Gene"                                                                                                                                                         
[17901] "GLI_Family_Gene"                                                                                                                                                      
[17902] "FOSL1_Protein"                                                                                                                                                        
[17903] "FOSL2_Protein"                                                                                                                                                        
[17904] "FGF4_Gene"                                                                                                                                                            
[17905] "ABL2_Tyrosine_Kinase"                                                                                                                                                 
[17906] "JUN_Family_Protein"                                                                                                                                                   
[17907] "A-RAF_Protein_Kinase"                                                                                                                                                 
[17908] "MYC-Family_Oncogene"                                                                                                                                                  
[17909] "MYC_Family_Gene"                                                                                                                                                      
[17910] "MYC_Family_Protein"                                                                                                                                                   
[17911] "RET_Protein"                                                                                                                                                          
[17912] "SRC_Family_Oncogene"                                                                                                                                                  
[17913] "LCK_Gene"                                                                                                                                                             
[17914] "FGR_Gene"                                                                                                                                                             
[17915] "YES1_Gene"                                                                                                                                                            
[17916] "Tumor-Associated_Calcium_Signal_Transducer-2"                                                                                                                         
[17917] "MAF_Family_Gene"                                                                                                                                                      
[17918] "MAF_Family_Protein"                                                                                                                                                   
[17919] "CBL_Protein"                                                                                                                                                          
[17920] "NTRK1_Tropomyosin_Chimeric_Protein"                                                                                                                                   
[17921] "RAS_Superfamily_Protein"                                                                                                                                              
[17922] "NF-Kappa_B_p49-p100_Protein"                                                                                                                                          
[17923] "NTRK1_Gene"                                                                                                                                                           
[17924] "ETS_Family_Protein"                                                                                                                                                   
[17925] "SPI1_Gene"                                                                                                                                                            
[17926] "TIAM1_Protein"                                                                                                                                                        
[17927] "SPI1_Oncoprotein"                                                                                                                                                     
[17928] "p61-YES"                                                                                                                                                              
[17929] "Transforming_Protein-ERG"                                                                                                                                             
[17930] "p60-HCK"                                                                                                                                                              
[17931] "TFAP2A_Gene"                                                                                                                                                          
[17932] "WNT1_Protein"                                                                                                                                                         
[17933] "WNT5A_Protein"                                                                                                                                                        
[17934] "Thyroid_Hormone_Receptor_Gene"                                                                                                                                        
[17935] "WT2_Protein"                                                                                                                                                          
[17936] "BLYM_Oncoprotein"                                                                                                                                                     
[17937] "FLI1_Transcription_Factor"                                                                                                                                            
[17938] "Apoptosis_Promoter"                                                                                                                                                   
[17939] "Fibroblast_Growth_Factor_Gene_Family"                                                                                                                                 
[17940] "FGF2_Gene"                                                                                                                                                            
[17941] "FGF7_Gene"                                                                                                                                                            
[17942] "FGF5_Gene"                                                                                                                                                            
[17943] "Proto-Oncogene_Growth_Factor_Receptor"                                                                                                                                
[17944] "RET-H4_Oncogene"                                                                                                                                                      
[17945] "Angiogenesis_Promoter"                                                                                                                                                
[17946] "Insulin-Like_Growth_Factor-Binding_Protein-9"                                                                                                                         
[17947] "MAX_Gene"                                                                                                                                                             
[17948] "TP73_Protein"                                                                                                                                                         
[17949] "FPS-FES_Protein"                                                                                                                                                      
[17950] "RUNX1_Gene"                                                                                                                                                           
[17951] "PTTG1_Gene"                                                                                                                                                           
[17952] "Securin"                                                                                                                                                              
[17953] "Angiogenesis_Inhibitory_Protein"                                                                                                                                      
[17954] "ATM_Gene"                                                                                                                                                             
[17955] "CBFB_Gene"                                                                                                                                                            
[17956] "MLL_Gene"                                                                                                                                                             
[17957] "Tumor_Promoter_Induced_Gene"                                                                                                                                          
[17958] "GSTM1_Gene"                                                                                                                                                           
[17959] "COMT_Gene"                                                                                                                                                            
[17960] "PMS1_Gene"                                                                                                                                                            
[17961] "PMS2_Gene"                                                                                                                                                            
[17962] "TGFBR2_Gene"                                                                                                                                                          
[17963] "Cyclin-Dependent_Kinase_Inhibitor_Gene"                                                                                                                               
[17964] "BLCA-4"                                                                                                                                                               
[17965] "Susceptibility-Resistance_Gene"                                                                                                                                       
[17966] "Ultrastructural_Pathology"                                                                                                                                            
[17967] "DNA_Binding"                                                                                                                                                          
[17968] "Apoptosis_Inhibitor"                                                                                                                                                  
[17969] "Biomarker_of_Dietary_Intake"                                                                                                                                          
[17970] "PIM-1_Serine-Threonine_Kinase"                                                                                                                                        
[17971] "PVT1_Protein"                                                                                                                                                         
[17972] "Chromatin_Remodeling_Factor"                                                                                                                                          
[17973] "FURIN_Gene"                                                                                                                                                           
[17974] "Oncogene_MAX"                                                                                                                                                         
[17975] "Patched"                                                                                                                                                              
[17976] "Ephrin_Receptor"                                                                                                                                                      
[17977] "TM4SF1_Gene"                                                                                                                                                          
[17978] "HOX11_Gene"                                                                                                                                                           
[17979] "C-KIT_Gene"                                                                                                                                                           
[17980] "Pharmacology_Other"                                                                                                                                                   
[17981] "Office_of_Administrative_Management"                                                                                                                                  
[17982] "Academic_Career_Award"                                                                                                                                                
[17983] "Academic_Grants_and_Contracts_Administration"                                                                                                                         
[17984] "Acute_Illnesses_Nursing"                                                                                                                                              
[17985] "Administrative_Supplements_to_Research_Grants"                                                                                                                        
[17986] "Adult_Health_Nursing"                                                                                                                                                 
[17987] "Aging_Other"                                                                                                                                                          
[17988] "AIDS_Epidemiology"                                                                                                                                                    
[17989] "AIDS_Population"                                                                                                                                                      
[17990] "AIDS_Related_Research_Women"                                                                                                                                          
[17991] "AIDS_Black"                                                                                                                                                           
[17992] "AIDS_Hispanic"                                                                                                                                                        
[17993] "AIDS_Homosexual"                                                                                                                                                      
[17994] "AIDS_International"                                                                                                                                                   
[17995] "AIDS_Minority"                                                                                                                                                        
[17996] "AIDS_Other_Minorities"                                                                                                                                                
[17997] "AIDS_Women"                                                                                                                                                           
[17998] "Allied_Health_Sciences_Education_and_Training"                                                                                                                        
[17999] "Allied_Health_Sciences_Other"                                                                                                                                         
[18000] "Analytical_Biochemistry"                                                                                                                                              
[18001] "Animal_Genetics"                                                                                                                                                      
[18002] "Animal_Sources"                                                                                                                                                       
[18003] "Academic_Research_Enhancement_Award"                                                                                                                                  
[18004] "Auditory_Physiology"                                                                                                                                                  
[18005] "Auditory_Psychophysics"                                                                                                                                               
[18006] "Autoradiography_Microscopic"                                                                                                                                          
[18007] "Autoradiography_Quantitative"                                                                                                                                         
[18008] "Bioassay_in_vitro"                                                                                                                                                    
[18009] "Bioassay_in_vivo"                                                                                                                                                     
[18010] "Biochemical_Endocrinology"                                                                                                                                            
[18011] "Biochemical_Energetics"                                                                                                                                               
[18012] "Biochemical_Epidemiology"                                                                                                                                             
[18013] "Enzymology"                                                                                                                                                           
[18014] "Biochemistry_Other"                                                                                                                                                   
[18015] "Bioengineering_Other"                                                                                                                                                 
[18016] "Bioinstrument_Application_and_Development"                                                                                                                            
[18017] "Biological_Testing"                                                                                                                                                   
[18018] "Biology_of_HIV_Infection"                                                                                                                                             
[18019] "Biology_Other"                                                                                                                                                        
[18020] "Biomedical_Research_Careers_Notice"                                                                                                                                   
[18021] "Biomolecule_Separations_Technology"                                                                                                                                   
[18022] "Biophysics_Bioengineering_and_Instrumentation"                                                                                                                        
[18023] "Biophysics_Other"                                                                                                                                                     
[18024] "Biotechnology_Fermentation"                                                                                                                                           
[18025] "Biotechnology_Mass_Cell_Culture"                                                                                                                                      
[18026] "Biotechnology_Synthetic_Nucleic_Acid_Peptide"                                                                                                                         
[18027] "Bishop-Calabresi_Report"                                                                                                                                              
[18028] "Bone_and_Connective_Tissue_Pathology"                                                                                                                                 
[18029] "Bone_and_Connective_Tissue_Physiology"                                                                                                                                
[18030] "Breast_Cancer_Education"                                                                                                                                              
[18031] "Breast_Cancer_Genetics"                                                                                                                                               
[18032] "Breast_Cancer_Treatment_and_Rehabilitation"                                                                                                                           
[18033] "Breast_Cancer_Epidemiology"                                                                                                                                           
[18034] "Cancer_Biology"                                                                                                                                                       
[18035] "Office_of_Cancer_Information_Communication_and_Education"                                                                                                             
[18036] "Cancer_Epidemiology"                                                                                                                                                  
[18037] "Cancer_Etiology"                                                                                                                                                      
[18038] "Cancer_Immunology"                                                                                                                                                    
[18039] "Cancer_Prevention_Fellowship_Program"                                                                                                                                 
[18040] "Cancer_Prognosis"                                                                                                                                                     
[18041] "Cancer_Survivor"                                                                                                                                                      
[18042] "Cancer_Survivorship"                                                                                                                                                  
[18043] "Cancer_Viral"                                                                                                                                                         
[18044] "Carbohydrate_Biochemistry"                                                                                                                                            
[18045] "Carbohydrate_Chemistry"                                                                                                                                               
[18046] "Biological_Carcinogenesis"                                                                                                                                            
[18047] "Carcinogenesis_Co-Carcinogenesis"                                                                                                                                     
[18048] "Hormonal_Carcinogenesis"                                                                                                                                              
[18049] "Carcinogenesis_Mechanism"                                                                                                                                             
[18050] "Physical_Carcinogenesis"                                                                                                                                              
[18051] "Carcinogenesis_Radiation"                                                                                                                                             
[18052] "Cardiopulmonary_Physiology"                                                                                                                                           
[18053] "cDNA_Library_Construction"                                                                                                                                            
[18054] "cDNA_Subtraction"                                                                                                                                                     
[18055] "cDNA_Expression"                                                                                                                                                      
[18056] "Cell_Biology_Other"                                                                                                                                                   
[18057] "Cell_Cycle_Checkpoint"                                                                                                                                                
[18058] "Cellular_Immunology"                                                                                                                                                  
[18059] "Cerebrovascular_Physiology"                                                                                                                                           
[18060] "Cervical_Cancer_Education"                                                                                                                                            
[18061] "Chemistry_Other"                                                                                                                                                      
[18062] "Chemistry_Quantitative"                                                                                                                                               
[18063] "Chicken_Cells"                                                                                                                                                        
[18064] "Child_and_Family_Social_Services"                                                                                                                                     
[18065] "Chromosome_Rearrangement_Detection"                                                                                                                                   
[18066] "Chromosome_Transfer"                                                                                                                                                  
[18067] "Clinical_Dental_Sciences_Other"                                                                                                                                       
[18068] "Clinical_Endocrinology"                                                                                                                                               
[18069] "Clinical_Immunology"                                                                                                                                                  
[18070] "Clinical_Microbiology"                                                                                                                                                
[18071] "Clinical_Nursing_Care_Other"                                                                                                                                          
[18072] "Clinical_Nursing_Sciences_Other"                                                                                                                                      
[18073] "Clinical_Parasitology"                                                                                                                                                
[18074] "Clinical_Sciences"                                                                                                                                                    
[18075] "Clinical_Trials_Adjunct"                                                                                                                                              
[18076] "Clinical_Virology"                                                                                                                                                    
[18077] "Colloquia_Series_Including_Statistical_Colloquia"                                                                                                                     
[18078] "Combinatorial_Synthesis_of_Biomolecules"                                                                                                                              
[18079] "Communication_Research"                                                                                                                                               
[18080] "Comparative_Biochemistry"                                                                                                                                             
[18081] "Computer_Sciences_Other"                                                                                                                                              
[18082] "Concept_Review"                                                                                                                                                       
[18083] "Conference_Grant_Guidelines"                                                                                                                                          
[18084] "Conjugated_Carrier"                                                                                                                                                   
[18085] "Consequences_of_HIV"                                                                                                                                                  
[18086] "Consumer_Liaison"                                                                                                                                                     
[18087] "Contracts_Review"                                                                                                                                                     
[18088] "Coordinating_Center_Administration"                                                                                                                                   
[18089] "Coordination_and_Collaboration"                                                                                                                                       
[18090] "Culturally_and_Economically_Diverse_Group"                                                                                                                            
[18091] "Cyclic_Nucleotide_Biochemistry"                                                                                                                                       
[18092] "Cyclic_Nucleotide_Pharmacology"                                                                                                                                       
[18093] "Cytidylyltransferase"                                                                                                                                                 
[18094] "Data_Base_Management"                                                                                                                                                 
[18095] "Dental_Epidemiology"                                                                                                                                                  
[18096] "Dental_Sciences_Clinical"                                                                                                                                             
[18097] "Development-Other"                                                                                                                                                    
[18098] "Developmental_Biochemistry"                                                                                                                                           
[18099] "Developmental_Cell_Biology"                                                                                                                                           
[18100] "Developmental_Endocrinology"                                                                                                                                          
[18101] "Developmental_Physiology_Differentiation_Growth"                                                                                                                      
[18102] "Developmental_Psychology_Adolescence"                                                                                                                                 
[18103] "Developmental_Psychology_Adult"                                                                                                                                       
[18104] "Developmental_Psychology_Aged"                                                                                                                                        
[18105] "Developmental_Psychology_General"                                                                                                                                     
[18106] "Device_or_Instrument_Development"                                                                                                                                     
[18107] "Diagnostic_or_Prognostic_Tests"                                                                                                                                       
[18108] "Dietary_Epidemiology"                                                                                                                                                 
[18109] "Dietary_Factors"                                                                                                                                                      
[18110] "Differentiation_and_Growth"                                                                                                                                           
[18111] "Directors_Working_Group"                                                                                                                                              
[18112] "Discover_and_Develop_HIV_Treatments-Preclinical"                                                                                                                      
[18113] "Division_of_Cancer_Biology"                                                                                                                                           
[18114] "Division_of_Cancer_Epidemiology_and_Genetics"                                                                                                                         
[18115] "Division_of_Cancer_Prevention"                                                                                                                                        
[18116] "Division_of_Cancer_Treatment_and_Diagnosis"                                                                                                                           
[18117] "Division_of_Clinical_Sciences"                                                                                                                                        
[18118] "Division_of_Extramural_Activities"                                                                                                                                    
[18119] "Radiation_Induced_DNA_Damage"                                                                                                                                         
[18120] "DNA-Protein_Interaction"                                                                                                                                              
[18121] "Dominant-Negative_Mutation"                                                                                                                                           
[18122] "Drosophila_Patched_Gene"                                                                                                                                              
[18123] "Epstein_Barr_Nuclear_Antigen-3"                                                                                                                                       
[18124] "Egg_Preservation"                                                                                                                                                     
[18125] "Embryo_Preservation"                                                                                                                                                  
[18126] "Endocrine_Epidemiology"                                                                                                                                               
[18127] "Enhancing_Accessibility_to_Health_Care"                                                                                                                               
[18128] "Environmental_Engineering_Atmosphere"                                                                                                                                 
[18129] "Environmental_Engineering_Land"                                                                                                                                       
[18130] "Environmental_Engineering_Water"                                                                                                                                      
[18131] "Environmental_Health_Sciences"                                                                                                                                        
[18132] "Environmental_Health_Sciences_Other"                                                                                                                                  
[18133] "Epidemiology_Age_Sex"                                                                                                                                                 
[18134] "Environmental_Epidemiology"                                                                                                                                           
[18135] "Epidemiology_Geographic_Location"                                                                                                                                     
[18136] "Epidemiology_Occupation"                                                                                                                                              
[18137] "Personal_Medical_History"                                                                                                                                             
[18138] "Epidemiology_Race_Ethnic_Origin"                                                                                                                                      
[18139] "Epidemiology_Tobacco_Alcohol_Drugs"                                                                                                                                   
[18140] "Epithelial_Physiology"                                                                                                                                                
[18141] "Epithelial-Stromal_Communication"                                                                                                                                     
[18142] "Exercise_Physiology_and_Stress"                                                                                                                                       
[18143] "Expedite_Dissemination"                                                                                                                                               
[18144] "Experimental_Models_Other"                                                                                                                                            
[18145] "Experimental_Ophthalmology"                                                                                                                                           
[18146] "Experimental_Pathology_Other_Than_Tumors"                                                                                                                             
[18147] "Experimental_Pathology_Tumors"                                                                                                                                        
[18148] "Experimental_Psychology_Animal"                                                                                                                                       
[18149] "Experimental_Psychology_Human"                                                                                                                                        
[18150] "Experimental_Tumor"                                                                                                                                                   
[18151] "Extra-Nuclear_Genetics"                                                                                                                                               
[18152] "Extramural_Activities"                                                                                                                                                
[18153] "Extramural_Epidemiology_and_Genetics_Program"                                                                                                                         
[18154] "Extramural_Policy_Announcements"                                                                                                                                      
[18155] "Family_Health_Nursing"                                                                                                                                                
[18156] "Family_Sociology"                                                                                                                                                     
[18157] "Fellowship_Programs_DCEG"                                                                                                                                             
[18158] "Fellowship_Programs_F-Series"                                                                                                                                         
[18159] "Fiber_Chemistry"                                                                                                                                                      
[18160] "First_Independent_Research_Support_and_Transition_Awards"                                                                                                             
[18161] "Five-A-Day_Program"                                                                                                                                                   
[18162] "Analytical_Centrifugation"                                                                                                                                            
[18163] "Elutriative_Centrifugation"                                                                                                                                           
[18164] "Preparative_Centrifugation"                                                                                                                                           
[18165] "Chemical_Fractionation"                                                                                                                                               
[18166] "Frederick_Cancer_Research_and_Development_Center"                                                                                                                     
[18167] "Gastrointestinal_Physiology"                                                                                                                                          
[18168] "Gene_Knock-Out_Model"                                                                                                                                                 
[18169] "Gene_Mapping_Human"                                                                                                                                                   
[18170] "Gene_Mapping_Non-Human"                                                                                                                                               
[18171] "Genetic_Medicine"                                                                                                                                                     
[18172] "Genetic_Models_for_Cancer"                                                                                                                                            
[18173] "Genetic_Risk"                                                                                                                                                         
[18174] "Genetic_Toxicology"                                                                                                                                                   
[18175] "Applied_Genetics"                                                                                                                                                     
[18176] "Experimental_Genetics"                                                                                                                                                
[18177] "Genetics_Other"                                                                                                                                                       
[18178] "Gerontological_Nursing"                                                                                                                                               
[18179] "Global_Change"                                                                                                                                                        
[18180] "Global_Change_UV"                                                                                                                                                     
[18181] "Glycobiology"                                                                                                                                                         
[18182] "Grant_Opportunities_DCB"                                                                                                                                              
[18183] "Grant_Referral_and_Review"                                                                                                                                            
[18184] "Grants_and_Contracts_Operations"                                                                                                                                      
[18185] "Grants_and_Contracts_NIH"                                                                                                                                             
[18186] "Award_Guidelines"                                                                                                                                                     
[18187] "Grants_Preparing_Applications"                                                                                                                                        
[18188] "Group_Affiliation"                                                                                                                                                    
[18189] "Cell_Cycle_Inhibition"                                                                                                                                                
[18190] "Growth"                                                                                                                                                               
[18191] "Gynecologic_Pathology"                                                                                                                                                
[18192] "Gynecological_Obstetrical_Nursing"                                                                                                                                    
[18193] "Health_and_Behavior_Intramural_Dollars"                                                                                                                               
[18194] "Health_and_Behavior_Training_Dollars"                                                                                                                                 
[18195] "Health_Promotion_and_Care"                                                                                                                                            
[18196] "Health_Promotion_and_Care-Work_Site"                                                                                                                                  
[18197] "Health_Promotion_in_Nursing"                                                                                                                                          
[18198] "Health_Promotion_Sciences"                                                                                                                                            
[18199] "Herpes_Other_Than_Genital"                                                                                                                                            
[18200] "High_Percent_Effort"                                                                                                                                                  
[18201] "High-LET_Radiation"                                                                                                                                                   
[18202] "HIV_and_HIV_Genome"                                                                                                                                                   
[18203] "HIV_Surveys_Incidence_and_Prevalence"                                                                                                                                 
[18204] "Host_Defense_Mechanism"                                                                                                                                               
[18205] "Howard_Temin_Award_Guidelines"                                                                                                                                        
[18206] "Human_Fetal_Tissue"                                                                                                                                                   
[18207] "Hybridization_Array"                                                                                                                                                  
[18208] "Imaging_Technology"                                                                                                                                                   
[18209] "Immune_Reconstitution_Approaches_for_HIV"                                                                                                                             
[18210] "Immunologic_Epidemiology"                                                                                                                                             
[18211] "Immunotoxicology"                                                                                                                                                     
[18212] "Improve_Access"                                                                                                                                                       
[18213] "Independent_Scientist_Award_Guidelines"                                                                                                                               
[18214] "Individual_Cancer_History"                                                                                                                                            
[18215] "Non-AIDS_Infant_Mortality"                                                                                                                                            
[18216] "Infectious_Disease_Epidemiology"                                                                                                                                      
[18217] "Infrastructure_Domestic_and_International"                                                                                                                            
[18218] "Inhalation_Toxicology"                                                                                                                                                
[18219] "Institutional_National_Research_Service_Award"                                                                                                                        
[18220] "DNA_Integration"                                                                                                                                                      
[18221] "Intramural_Research_Training_Award"                                                                                                                                   
[18222] "Intramural_Research_Program"                                                                                                                                          
[18223] "Invertebrate_Biology"                                                                                                                                                 
[18224] "Invertebrate_Tissue_and_Cells"                                                                                                                                        
[18225] "Laboratory_Animal_Medicine"                                                                                                                                           
[18226] "Lipid_Biochemistry"                                                                                                                                                   
[18227] "Lipid_Chemistry"                                                                                                                                                      
[18228] "LMP1"                                                                                                                                                                 
[18229] "Low_Prevalence"                                                                                                                                                       
[18230] "Lymphocyte_Biology"                                                                                                                                                   
[18231] "Macrophage_Cell_Biology"                                                                                                                                              
[18232] "Mathematical_Biology"                                                                                                                                                 
[18233] "Medical_Entomology"                                                                                                                                                   
[18234] "Medical_Imaging_Virtual_Reality"                                                                                                                                      
[18235] "Medical_Radiation_Physics"                                                                                                                                            
[18236] "Medicine_Precancer"                                                                                                                                                   
[18237] "Mentored_Clinical_Scientist_Development_Award"                                                                                                                        
[18238] "Microbial_Physiology"                                                                                                                                                 
[18239] "Medical_Microbiology"                                                                                                                                                 
[18240] "Microbiology_Other"                                                                                                                                                   
[18241] "Microscopy_Electron_Other"                                                                                                                                            
[18242] "Microscopy_Light_Other"                                                                                                                                               
[18243] "Quantitative_Microscopy"                                                                                                                                              
[18244] "Minority_Health_and_Assistance_Targeted"                                                                                                                              
[18245] "Modeling_of_Functional_Interactions"                                                                                                                                  
[18246] "Nucleic_Acid_Sequencing"                                                                                                                                              
[18247] "Molecular_Biology_Other"                                                                                                                                              
[18248] "Protein_Sequencing"                                                                                                                                                   
[18249] "Molecular_Cytogenetics"                                                                                                                                               
[18250] "Molecular_Medicine"                                                                                                                                                   
[18251] "Molecular_Receptor_Pharmacology"                                                                                                                                      
[18252] "Molecular_Virology"                                                                                                                                                   
[18253] "mRNA_Expression"                                                                                                                                                      
[18254] "Muscle_Physiology_Contractile"                                                                                                                                        
[18255] "Mutation_Detection"                                                                                                                                                   
[18256] "Mutation_Spectra"                                                                                                                                                     
[18257] "Mycology_Nonclinical"                                                                                                                                                 
[18258] "National_Cancer_Program"                                                                                                                                              
[18259] "National_Cancer_Advisory_Board"                                                                                                                                       
[18260] "NCI_Program_T_P_or_N"                                                                                                                                                 
[18261] "Strategic_Planning"                                                                                                                                                   
[18262] "Neurofibromatosis_Related"                                                                                                                                            
[18263] "Neurogenetics"                                                                                                                                                        
[18264] "Neurovirology"                                                                                                                                                        
[18265] "Individual_National_Research_Service_Award"                                                                                                                           
[18266] "Request_for_Applications"                                                                                                                                             
[18267] "None_or_Not_Applicable"                                                                                                                                               
[18268] "Nucleic_Acid_Biochemistry_Synthesis"                                                                                                                                  
[18269] "Nutrition_Training_Dollars"                                                                                                                                           
[18270] "Occupational_Carcinogenesis"                                                                                                                                          
[18271] "Occupational_Epidemiology"                                                                                                                                            
[18272] "Ocular_Pathology"                                                                                                                                                     
[18273] "Older_Population"                                                                                                                                                     
[18274] "Oncogene_Activation"                                                                                                                                                  
[18275] "Oncogene_E1A-E1B"                                                                                                                                                     
[18276] "Oncology_Other"                                                                                                                                                       
[18277] "Optical_Methods"                                                                                                                                                      
[18278] "Oral_Microbiology"                                                                                                                                                    
[18279] "Organometallic_Chemistry"                                                                                                                                             
[18280] "Other_Minority"                                                                                                                                                       
[18281] "Other_Multiple_Areas"                                                                                                                                                 
[18282] "Other_Support_Update"                                                                                                                                                 
[18283] "Other_Types_of_Training"                                                                                                                                              
[18284] "Outcomes_of_Therapy"                                                                                                                                                  
[18285] "Outreach_Research"                                                                                                                                                    
[18286] "Oxidative_Regulation"                                                                                                                                                 
[18287] "Program_Research_Project_Grants"                                                                                                                                      
[18288] "Pathogenesis_of_HIV_Malignancy"                                                                                                                                       
[18289] "Pathogenesis_of_HIV_Neurological_Disease"                                                                                                                             
[18290] "Pathogenesis_of_HIV_Opportunistic_Infection"                                                                                                                          
[18291] "Pathogenesis_of_HIV-Related_Organ_Tissue_Disorder"                                                                                                                    
[18292] "Pathology_of_Tumors_in_Animals"                                                                                                                                       
[18293] "Insurance_and_Payment_Issues"                                                                                                                                         
[18294] "Pediatric_Adolescence_Nursing"                                                                                                                                        
[18295] "Peptide_MHC_Complex"                                                                                                                                                  
[18296] "Perinatal_Epidemiology"                                                                                                                                               
[18297] "Peroxisome_Proliferation"                                                                                                                                             
[18298] "Pesticide_Toxicology"                                                                                                                                                 
[18299] "Phage_Display"                                                                                                                                                        
[18300] "Pharmacology_Biologicals"                                                                                                                                             
[18301] "Pharmacology-Drug_Structure"                                                                                                                                          
[18302] "Photometry_Spectrum_Analysis_Visible_Light"                                                                                                                           
[18303] "Photometry_Spectrum_Analysis_X-ray_Neutron"                                                                                                                           
[18304] "Phylogenetic_Analysis"                                                                                                                                                
[18305] "Electromagnetic_Flux"                                                                                                                                                 
[18306] "Phospholipase-C_Gamma-2"                                                                                                                                              
[18307] "Planning_Evaluation_and_Analysis"                                                                                                                                     
[18308] "Plant_Sources"                                                                                                                                                        
[18309] "Plant_Tissue_Cells"                                                                                                                                                   
[18310] "Policy_Notice_NIH"                                                                                                                                                    
[18311] "RNA_Polyadenylation"                                                                                                                                                  
[18312] "Polymer_Chemistry"                                                                                                                                                    
[18313] "Population_Analysis"                                                                                                                                                  
[18314] "Population_Psychology"                                                                                                                                                
[18315] "Post_Translational_Modification_Analysis"                                                                                                                             
[18316] "Post-Transcriptional_Regulation"                                                                                                                                      
[18317] "Pre-Clinical_Model"                                                                                                                                                   
[18318] "Prediction_of_Response_to_Therapy"                                                                                                                                    
[18319] "Predoctoral_Fellowship-Minority_Students"                                                                                                                             
[18320] "Predoctoral_Fellowship-Students_with_Disabilities"                                                                                                                    
[18321] "Preparation_for_Vaccine_Efficacy_Trials"                                                                                                                              
[18322] "Prevention_Capacity_Enhancement"                                                                                                                                      
[18323] "Prognostic_Factor"                                                                                                                                                    
[18324] "Progress_Review_Group"                                                                                                                                                
[18325] "Prostaglandin_Pharmacology"                                                                                                                                           
[18326] "Protein_Analysis"                                                                                                                                                     
[18327] "Protein-Carbohydrate_Interaction"                                                                                                                                     
[18328] "Protein_Chemistry"                                                                                                                                                    
[18329] "Protein_Disruption_Model"                                                                                                                                             
[18330] "Protein_Expression"                                                                                                                                                   
[18331] "Protein_Function"                                                                                                                                                     
[18332] "Protein_Hormone_Receptor"                                                                                                                                             
[18333] "Protein_Import"                                                                                                                                                       
[18334] "Protein_Kinase_Protein_Phosphorylation"                                                                                                                               
[18335] "Protein_Secretion"                                                                                                                                                    
[18336] "Protein_Amino_Acid_Biochemistry_Degradation_and_Protease_Chemistry"                                                                                                   
[18337] "Protein_Amino_Acid_Biochemistry_Enzymology"                                                                                                                           
[18338] "Protein_Amino_Acid_Biochemistry_Synthesis"                                                                                                                            
[18339] "Public_Health_Education"                                                                                                                                              
[18340] "Pulmonary_Pharmacology_Toxicology"                                                                                                                                    
[18341] "PUR_Alpha_Protein"                                                                                                                                                    
[18342] "Radiation_Biology_Electromagnetic_Fields"                                                                                                                             
[18343] "Radiation_Biology_Low_Level_Ionizing_Radiation"                                                                                                                       
[18344] "Radiation_Ionizing_Diagnostic_Imaging"                                                                                                                                
[18345] "Radiation_Non-Ionizing_Diagnostic_Imaging"                                                                                                                            
[18346] "Charged_Particles_Radiation"                                                                                                                                          
[18347] "Low-Level_Ionizing_Radiation"                                                                                                                                         
[18348] "Non-Ionizing_Radiation_DX_or_RX"                                                                                                                                      
[18349] "Radioimmune_Chemistry"                                                                                                                                                
[18350] "Radiology_Bone"                                                                                                                                                       
[18351] "Radiology_Dental"                                                                                                                                                     
[18352] "Radiology_Head_Neck"                                                                                                                                                  
[18353] "Radiology_Soft_Tissue"                                                                                                                                                
[18354] "Radiology_Thorax_Chest"                                                                                                                                               
[18355] "Receptor_Biology_and_Gene_Expression"                                                                                                                                 
[18356] "Receptor_Signaling"                                                                                                                                                   
[18357] "Recombinant_Antibody"                                                                                                                                                 
[18358] "Reduction_of_Opportunistic_Illness"                                                                                                                                   
[18359] "Regulatory_Affairs"                                                                                                                                                   
[18360] "Renal_Pharmacology"                                                                                                                                                   
[18361] "Renal_Urogenital_Pathology"                                                                                                                                           
[18362] "Repair_Enzymology"                                                                                                                                                    
[18363] "Reproduction_Other"                                                                                                                                                   
[18364] "Reproductive_Biology"                                                                                                                                                 
[18365] "Reproductive_Endocrinology"                                                                                                                                           
[18366] "Reproductive_Physiology"                                                                                                                                              
[18367] "Research_Construction_Programs_C-Series"                                                                                                                              
[18368] "Research_Contracts"                                                                                                                                                   
[18369] "Research_Methods"                                                                                                                                                     
[18370] "Research_Program_Projects_and_Centers_P-Series"                                                                                                                       
[18371] "Research_Supplements_for_Underrepresented_Minorities_Notice"                                                                                                          
[18372] "Research_Supplements_to_Promote_the_Recruitment_of_Individuals_with_Disabilities"                                                                                     
[18373] "Research_Training"                                                                                                                                                    
[18374] "Research-Related_Programs_S-Series"                                                                                                                                   
[18375] "Reservations"                                                                                                                                                         
[18376] "Resource_Sharing"                                                                                                                                                     
[18377] "Retinoid_Receptor"                                                                                                                                                    
[18378] "Retrovirology"                                                                                                                                                        
[18379] "Risk_Estimate"                                                                                                                                                        
[18380] "Risk_Factors_and_Mechanisms_of_HIV_Transmission"                                                                                                                      
[18381] "RNA_Folding"                                                                                                                                                          
[18382] "RNA_Synthesis"                                                                                                                                                        
[18383] "RNA-Protein_Interaction"                                                                                                                                              
[18384] "Receiver_Operator_Characteristics"                                                                                                                                    
[18385] "Rodent_Model"                                                                                                                                                         
[18386] "Small_Business_Innovation_Research_Grant"                                                                                                                             
[18387] "School_Health_Nursing"                                                                                                                                                
[18388] "Science_Enrichment"                                                                                                                                                   
[18389] "Science_Policy"                                                                                                                                                       
[18390] "Scientific_Publications"                                                                                                                                              
[18391] "Senior_Scientist_Award_Guidelines"                                                                                                                                    
[18392] "Sensory_and_Communicative_Sciences"                                                                                                                                   
[18393] "Sensory_Physiology"                                                                                                                                                   
[18394] "Sequencing_Biochemistry"                                                                                                                                              
[18395] "Shannon_Awards_Guidelines"                                                                                                                                            
[18396] "Site_Visit"                                                                                                                                                           
[18397] "Skin_Carcinogenesis"                                                                                                                                                  
[18398] "American_Stop_Smoking_Intervention_for_Cancer_Prevention"                                                                                                             
[18399] "Social_Networking"                                                                                                                                                    
[18400] "Sociobiology"                                                                                                                                                         
[18401] "Somatic_Cell_Genetics"                                                                                                                                                
[18402] "Special_Activities_Biological_Resources"                                                                                                                              
[18403] "Special_Interest_Category_Clinical_Trials_Code"                                                                                                                       
[18404] "Special_Interest_Category_Special_Area_Code"                                                                                                                          
[18405] "Spectroscopy_Circular_Dichroism"                                                                                                                                      
[18406] "State_and_Local_Projects_Risk_Assessment_and_Prevention"                                                                                                              
[18407] "State_or_Local_Health_Department"                                                                                                                                     
[18408] "Statistical_Methods"                                                                                                                                                  
[18409] "Stem_Cell_Development"                                                                                                                                                
[18410] "Steroid_Biochemistry"                                                                                                                                                 
[18411] "Structural_Biochemistry"                                                                                                                                              
[18412] "Structural_Chemistry"                                                                                                                                                 
[18413] "Small_Business_Technology_Transfer_Research"                                                                                                                          
[18414] "Support_Contracts"                                                                                                                                                    
[18415] "Surgery_Neonatal_Pediatric"                                                                                                                                           
[18416] "System_for_Primary_Care_Professionals"                                                                                                                                
[18417] "T-Cell_Activation"                                                                                                                                                    
[18418] "T-Cell_Transformation"                                                                                                                                                
[18419] "T-Cell_Development"                                                                                                                                                   
[18420] "Taxonomy_Invertebrate"                                                                                                                                                
[18421] "Taxonomy_Microbial"                                                                                                                                                   
[18422] "Taxonomy_Plant"                                                                                                                                                       
[18423] "Taxonomy_Vertebrate"                                                                                                                                                  
[18424] "TCR_Activation"                                                                                                                                                       
[18425] "Theoretical_Biology"                                                                                                                                                  
[18426] "Thoracic_Oncology"                                                                                                                                                    
[18427] "Thrombosis_Hemostasis_Platelet_Function"                                                                                                                              
[18428] "Thymocyte_Selection"                                                                                                                                                  
[18429] "Tissue_Specimen_Availability"                                                                                                                                         
[18430] "Tissue_Fresh"                                                                                                                                                         
[18431] "Title"                                                                                                                                                                
[18432] "TNF_Alpha_ICE_Proteinase"                                                                                                                                             
[18433] "Tobacco_Control_Research"                                                                                                                                             
[18434] "Analytical_Toxicology"                                                                                                                                                
[18435] "Toxicology_Antidotes_Treatment"                                                                                                                                       
[18436] "Toxicology_Biologicals"                                                                                                                                               
[18437] "Toxicology_Non-Drug"                                                                                                                                                  
[18438] "Trace_Element_Biochemistry"                                                                                                                                           
[18439] "Training_in_Biomedical_and_Behavioral_Research"                                                                                                                       
[18440] "Training_Programs_T-Series"                                                                                                                                           
[18441] "Transcriptional_Regulation"                                                                                                                                           
[18442] "Transient_Gene_Knock-Out_Model"                                                                                                                                       
[18443] "Recipient-Donor_Blood_Transmission"                                                                                                                                   
[18444] "Hemophilia-Population_Blood_Transmission"                                                                                                                             
[18445] "Intravenous_Drug_Abuser_Blood_Transmission"                                                                                                                           
[18446] "Occupationally-Related_Transmission"                                                                                                                                  
[18447] "Unclassified_Transmission"                                                                                                                                            
[18448] "Perinatal_Infectious_Transmission"                                                                                                                                    
[18449] "Sexual_Transmission"                                                                                                                                                  
[18450] "Transplacental_Carcinogenesis"                                                                                                                                        
[18451] "Transport_Models_Radionuclides"                                                                                                                                       
[18452] "Cellular_Transport_Process"                                                                                                                                           
[18453] "Treat_AIDS-Related_Malignancies"                                                                                                                                      
[18454] "Treat_AIDS-Related_Neurologic_Disease"                                                                                                                                
[18455] "Treat_Other_HIV-Associated_Complications"                                                                                                                             
[18456] "TTA_System"                                                                                                                                                           
[18457] "Tumor_Cell_Biology"                                                                                                                                                   
[18458] "Tumor_Immunity"                                                                                                                                                       
[18459] "Tumor_Immunology"                                                                                                                                                     
[18460] "Tumor_Immunology_and_Biology"                                                                                                                                         
[18461] "Tumor_Pathology"                                                                                                                                                      
[18462] "Tumor_Promotion"                                                                                                                                                      
[18463] "Cellular_Tumor_Suppression"                                                                                                                                           
[18464] "Ultraviolet_Radiation_Biology"                                                                                                                                        
[18465] "Underserved_Other_Than_Rural_Health"                                                                                                                                  
[18466] "Urologic_Oncology"                                                                                                                                                    
[18467] "UV-Mutagenesis"                                                                                                                                                       
[18468] "V-ABL"                                                                                                                                                                
[18469] "V-Ras-Ha"                                                                                                                                                             
[18470] "V-SRC"                                                                                                                                                                
[18471] "Viral_Cell_Proliferation"                                                                                                                                             
[18472] "Viral_Envelope_Gene"                                                                                                                                                  
[18473] "Viral_Epidemiology"                                                                                                                                                   
[18474] "Viral_Etiology_of_Cancer"                                                                                                                                             
[18475] "Viral_Genetics"                                                                                                                                                       
[18476] "Virology_and_Immunopathogenesis_of_HIV"                                                                                                                               
[18477] "Virology_Animal"                                                                                                                                                      
[18478] "Virology_DNA_Viruses_Adenovirus"                                                                                                                                      
[18479] "Virology_DNA_Viruses_General"                                                                                                                                         
[18480] "Virology_DNA_Viruses_Papillomavirus"                                                                                                                                  
[18481] "Virology_DNA_Viruses_Papovavirus"                                                                                                                                     
[18482] "Virology_DNA_Viruses_Polyomavirus"                                                                                                                                    
[18483] "Virology_Human"                                                                                                                                                       
[18484] "Virology_RNA_Viruses"                                                                                                                                                 
[18485] "Visual_Physiology"                                                                                                                                                    
[18486] "Visual_Psychophysics"                                                                                                                                                 
[18487] "Volunteer_Organization"                                                                                                                                               
[18488] "VPR_Gene"                                                                                                                                                             
[18489] "Whole_Organism_Analysis"                                                                                                                                              
[18490] "Whole_Organism_Cloning"                                                                                                                                               
[18491] "Women_s_Health_Nursing"                                                                                                                                               
[18492] "Antisense_Technology"                                                                                                                                                 
[18493] "Cancer_Research_Infrastructure"                                                                                                                                       
[18494] "Chemical_Dynamics"                                                                                                                                                    
[18495] "Deceptive_Imprinting"                                                                                                                                                 
[18496] "Expression_Technologies_for_DNA_and_RNA"                                                                                                                              
[18497] "Gene_Amplification_or_Deletion_Detection"                                                                                                                             
[18498] "NCI_Governance"                                                                                                                                                       
[18499] "Congress"                                                                                                                                                             
[18500] "President"                                                                                                                                                            
[18501] "NCI_Advisory_Boards_and_Groups"                                                                                                                                       
[18502] "Advocates"                                                                                                                                                            
[18503] "Board_of_Scientific_Counselors_NCI"                                                                                                                                   
[18504] "National_Cancer_Policy_Board"                                                                                                                                         
[18505] "Patient_or_Public_Education"                                                                                                                                          
[18506] "Population_Biology"                                                                                                                                                   
[18507] "Environment-to-Cell_Communication"                                                                                                                                    
[18508] "RNA_Degradation"                                                                                                                                                      
[18509] "Molecular_Transport"                                                                                                                                                  
[18510] "in_vitro_Model"                                                                                                                                                       
[18511] "Cell_Culture_System"                                                                                                                                                  
[18512] "in_vivo_Model"                                                                                                                                                        
[18513] "Tumor_Development_Stage"                                                                                                                                              
[18514] "Tumor_Progression_Process"                                                                                                                                            
[18515] "Metastasis"                                                                                                                                                           
[18516] "Molecular_Sequence_Alteration"                                                                                                                                        
[18517] "Viral_Oncogene"                                                                                                                                                       
[18518] "Pathologic_Mutagenesis"                                                                                                                                               
[18519] "Patterns_of_Care"                                                                                                                                                     
[18520] "Epidemiology_Other"                                                                                                                                                   
[18521] "Specimen"                                                                                                                                                             
[18522] "Research_Infrastructure"                                                                                                                                              
[18523] "Special_Equipment"                                                                                                                                                    
[18524] "Occupation_or_Discipline"                                                                                                                                             
[18525] "Business_Rules"                                                                                                                                                       
[18526] "Thrusts_I_II_III_IV_VI"                                                                                                                                               
[18527] "Presidents_Cancer_Panel"                                                                                                                                              
[18528] "Experimental_Pathology"                                                                                                                                               
[18529] "Cancer_Histology"                                                                                                                                                     
[18530] "Reproductive_Techniques"                                                                                                                                              
[18531] "Bacterial_Model"                                                                                                                                                      
[18532] "Fungi_Model"                                                                                                                                                          
[18533] "Plant_Model"                                                                                                                                                          
[18534] "Papillomavirus_Transforming_Protein-E6"                                                                                                                               
[18535] "Papillomavirus_Transforming_Protein-E7"                                                                                                                               
[18536] "DNA_Polymerase"                                                                                                                                                       
[18537] "Laryngectomee"                                                                                                                                                        
[18538] "Lower_GI_Series"                                                                                                                                                      
[18539] "Pneumatic_Larynx"                                                                                                                                                     
[18540] "Radioactive"                                                                                                                                                          
[18541] "Speech_Pathologist"                                                                                                                                                   
[18542] "Continent_Reservoir"                                                                                                                                                  
[18543] "Electrolarynx"                                                                                                                                                        
[18544] "Enterostomal_Therapist"                                                                                                                                               
[18545] "Antismoking"                                                                                                                                                          
[18546] "B_A_D_Codes"                                                                                                                                                          
[18547] "Causation_Research_Budget_Activity"                                                                                                                                   
[18548] "Colon_Rectum"                                                                                                                                                         
[18549] "Control_Budget_Activity"                                                                                                                                              
[18550] "Core_Assembly"                                                                                                                                                        
[18551] "Diagnostic_Radiology_Ionizing_and_Nonionizing"                                                                                                                        
[18552] "Genetic_Engineering_Applied"                                                                                                                                          
[18553] "Lung_Cancer_Women_Subset_of_Total_Lung"                                                                                                                               
[18554] "Mason_Codes"                                                                                                                                                          
[18555] "Medicine_Non-Malignant_Disease"                                                                                                                                       
[18556] "Primary_Nutrition_NCI_Program"                                                                                                                                        
[18557] "Urologic_Excluding_Kidney"                                                                                                                                            
[18558] "MSH6_Gene"                                                                                                                                                            
[18559] "Not_Site_Specific"                                                                                                                                                    
[18560] "Small_Business_Funding_Mechanisms"                                                                                                                                    
[18561] "Strategic_Code"                                                                                                                                                       
[18562] "Health_Sciences"                                                                                                                                                      
[18563] "Experimental_Psychology"                                                                                                                                              
[18564] "AIDS_Treatment_Research"                                                                                                                                              
[18565] "National_Cancer_Institute"                                                                                                                                            
[18566] "Office_of_the_Director"                                                                                                                                               
[18567] "Office_of_International_Affairs"                                                                                                                                      
[18568] "Office_of_Centers_Training_and_Resources"                                                                                                                             
[18569] "Office_of_Special_Populations_Research"                                                                                                                               
[18570] "Office_of_Budget_and_Financial_Management"                                                                                                                            
[18571] "Office_of_Legislative_and_Congressional_Activities"                                                                                                                   
[18572] "Journal_of_the_National_Cancer_Institute"                                                                                                                             
[18573] "Office_of_Science_Planning_and_Analysis"                                                                                                                              
[18574] "Office_of_Cancer_Genomics"                                                                                                                                            
[18575] "Office_of_Science_Opportunity"                                                                                                                                        
[18576] "Office_of_Management"                                                                                                                                                 
[18577] "Office_of_Liaison_Activities"                                                                                                                                         
[18578] "Division_of_Basic_Sciences"                                                                                                                                           
[18579] "Extramural_Research_Program"                                                                                                                                          
[18580] "Division_of_Cancer_Control_and_Population_Sciences"                                                                                                                   
[18581] "NCI_Board_of_Scientific_Advisors"                                                                                                                                     
[18582] "Prevention_Clinical_and_Therapeutic_Subcommittee"                                                                                                                     
[18583] "Cancer_Biology_Epidemiology_and_Genetics_Subcommittee"                                                                                                                
[18584] "Subcommittee_B_Basic_Sciences"                                                                                                                                        
[18585] "Subcommittee_A_Clinical_Sciences_and_Epidemiology"                                                                                                                    
[18586] "Other_Agency_or_Organization"                                                                                                                                         
[18587] "Department_of_Energy"                                                                                                                                                 
[18588] "Department_of_Defense"                                                                                                                                                
[18589] "Advisory_Committee_to_the_NCI_Director"                                                                                                                               
[18590] "NCI_Director_s_Consumer_Liaison_Group"                                                                                                                                
[18591] "Optical_Instrument"                                                                                                                                                   
[18592] "SSCP_Analysis"                                                                                                                                                        
[18593] "Dideoxy_Fingerprinting"                                                                                                                                               
[18594] "Autoradiography_Gross"                                                                                                                                                
[18595] "Preservation_Technique"                                                                                                                                               
[18596] "Computational_Technique"                                                                                                                                              
[18597] "Homology_Modeling"                                                                                                                                                    
[18598] "Molecular_Biology_Techniques"                                                                                                                                         
[18599] "Physical_Chemical_Techniques"                                                                                                                                         
[18600] "Subcommittee_to_Evaluate_the_National_Cancer_Program"                                                                                                                 
[18601] "Diagnostic_Therapeutic_and_Research_Equipment"                                                                                                                        
[18602] "AIDS_Infant_Mortality"                                                                                                                                                
[18603] "Deletion_Mutagenesis"                                                                                                                                                 
[18604] "S1_Protection"                                                                                                                                                        
[18605] "NEO_Gene"                                                                                                                                                             
[18606] "Luc_Gene"                                                                                                                                                             
[18607] "Socioeconomics"                                                                                                                                                       
[18608] "Social_Sciences_Other"                                                                                                                                                
[18609] "DNA_Ligation"                                                                                                                                                         
[18610] "Biomedical_Computing"                                                                                                                                                 
[18611] "Cost_Effective_Management"                                                                                                                                            
[18612] "Cost_Effectiveness_Analysis"                                                                                                                                          
[18613] "Economic_Burden"                                                                                                                                                      
[18614] "Stage_at_Diagnosis"                                                                                                                                                   
[18615] "Surveillance_Methods"                                                                                                                                                 
[18616] "Comorbidity_Index"                                                                                                                                                    
[18617] "Medical_Occupation"                                                                                                                                                   
[18618] "B-Cell_Activation"                                                                                                                                                    
[18619] "Cancer_Genetics_Network"                                                                                                                                              
[18620] "Molecular_Epidemiology_of_Prostate_Cancer"                                                                                                                            
[18621] "Cancer_Center_Supplements"                                                                                                                                            
[18622] "International_Consortium_on_Prostate_Cancer_Genetics"                                                                                                                 
[18623] "Mouse_Models_of_Human_Cancer"                                                                                                                                         
[18624] "Non-Mammalian_Organisms_as_Models_for_Cancer"                                                                                                                         
[18625] "Exploratory_Developmental_Grant_for_Diagnostic_Cancer_Imaging"                                                                                                        
[18626] "Laser_Capture_Microdissection"                                                                                                                                        
[18627] "Phased_Innovation_Awards"                                                                                                                                             
[18628] "Early_Detection_Research_Network"                                                                                                                                     
[18629] "Immune_Surveillance"                                                                                                                                                  
[18630] "Biochemistry_and_Pharmacology_Cancer_Activity"                                                                                                                        
[18631] "Resource_Informatics"                                                                                                                                                 
[18632] "Howard_Temin_Award"                                                                                                                                                   
[18633] "Independent_Scientist_Award"                                                                                                                                          
[18634] "Diagnostic_Imaging_Network"                                                                                                                                           
[18635] "Transgenic_Model"                                                                                                                                                     
[18636] "Heterotrimeric_G_Protein_Subunit"                                                                                                                                     
[18637] "G_Beta_Gamma"                                                                                                                                                         
[18638] "G-i_Alpha"                                                                                                                                                            
[18639] "G-q_Alpha"                                                                                                                                                            
[18640] "G_12_13_Alpha"                                                                                                                                                        
[18641] "Grb-2"                                                                                                                                                                
[18642] "Information_Sciences_Other"                                                                                                                                           
[18643] "Community_Oncology_and_Rehabilitation_Branch"                                                                                                                         
[18644] "Public_Health_Applications_Research_Branch"                                                                                                                           
[18645] "Immunology_Other"                                                                                                                                                     
[18646] "Cytochrome-P450-2D5"                                                                                                                                                  
[18647] "syk_Family_Tyrosine_Kinase"                                                                                                                                           
[18648] "TNF_Receptor_Family_Protein"                                                                                                                                          
[18649] "Tissue_Slice_Technology"                                                                                                                                              
[18650] "Commercial_Sources"                                                                                                                                                   
[18651] "Non-Commercial_Sources"                                                                                                                                               
[18652] "Research_Project_Grants"                                                                                                                                              
[18653] "Blue-Collar_Group"                                                                                                                                                    
[18654] "Epidemiological_Factors"                                                                                                                                              
[18655] "Organ_Transplant_Research"                                                                                                                                            
[18656] "Pathology_Other"                                                                                                                                                      
[18657] "Parasitology_Other"                                                                                                                                                   
[18658] "Insertion_Mutation"                                                                                                                                                   
[18659] "Deletion_Mutation"                                                                                                                                                    
[18660] "Neurosciences_Other"                                                                                                                                                  
[18661] "Nursing_Sciences_Clinical"                                                                                                                                            
[18662] "Fetal_Thymic_Organ_Culture"                                                                                                                                           
[18663] "Non-Rodent_Model"                                                                                                                                                     
[18664] "Comparative_Biology"                                                                                                                                                  
[18665] "Psychology_Other"                                                                                                                                                     
[18666] "Radiation_Biology_Other"                                                                                                                                              
[18667] "Magnetic_Bead_Technology"                                                                                                                                             
[18668] "CTLL-2_Assay"                                                                                                                                                         
[18669] "Hollow_Fiber_Apparatus"                                                                                                                                               
[18670] "Physiology_Other"                                                                                                                                                     
[18671] "Average_Household_Income"                                                                                                                                             
[18672] "Number_of_Children_in_Household"                                                                                                                                      
[18673] "Statistics_Other"                                                                                                                                                     
[18674] "Biologic_Permissiveness"                                                                                                                                              
[18675] "Long_Term_Survivorship"                                                                                                                                               
[18676] "Cryopreserved_Tissue"                                                                                                                                                 
[18677] "Cryopreserved_Cell"                                                                                                                                                   
[18678] "Primary_Cell_Culture"                                                                                                                                                 
[18679] "Allied_Health_Sciences"                                                                                                                                               
[18680] "Thymocyte_Development"                                                                                                                                                
[18681] "Reproductive_Immunology"                                                                                                                                              
[18682] "Subcellular_Targeting_Experimental"                                                                                                                                   
[18683] "Breast_Cancer_Model"                                                                                                                                                  
[18684] "Combinatorial_Synthesis"                                                                                                                                              
[18685] "Organic_Synthesis"                                                                                                                                                    
[18686] "Tumor_Biology"                                                                                                                                                        
[18687] "Supercomputing"                                                                                                                                                       
[18688] "RNA_Processing"                                                                                                                                                       
[18689] "Clinics_and_Hospitals"                                                                                                                                                
[18690] "Endocrinology_Other"                                                                                                                                                  
[18691] "Cooperative_Human_Tissue_Network"                                                                                                                                     
[18692] "NCI_Special_Emphasis_Panel"                                                                                                                                           
[18693] "NCI_Initial_Review_Group"                                                                                                                                             
[18694] "Adenosine_Receptor"                                                                                                                                                   
[18695] "Personal_Attribute"                                                                                                                                                   
[18696] "Intramural_Research_Award"                                                                                                                                            
[18697] "Targeted_Research"                                                                                                                                                    
[18698] "Funding_Category"                                                                                                                                                     
[18699] "Head_and_Neck_Subset_of_Total"                                                                                                                                        
[18700] "Diagnostic_Ultrasound"                                                                                                                                                
[18701] "Magnetic_Resonance_Elastography"                                                                                                                                      
[18702] "Optical_Image_Reconstruction"                                                                                                                                         
[18703] "Reflectance_or_Transmission_Spectroscopy"                                                                                                                             
[18704] "Multimodal_Imaging"                                                                                                                                                   
[18705] "Digital_Photography"                                                                                                                                                  
[18706] "Other_Imaging_Modalities"                                                                                                                                             
[18707] "Metabolic_Control"                                                                                                                                                    
[18708] "Chronic_Disorders_Nursing"                                                                                                                                            
[18709] "Culturing_in_vitro_Invertebrate"                                                                                                                                      
[18710] "Culturing_in_vitro_Microbial"                                                                                                                                         
[18711] "DNA_Replication_Damage"                                                                                                                                               
[18712] "Electrical_Engineering"                                                                                                                                               
[18713] "Nucleic_Acid_Biochemistry"                                                                                                                                            
[18714] "Nude_Mouse_Assay"                                                                                                                                                     
[18715] "Epidemiology_Descriptive"                                                                                                                                             
[18716] "Tobacco_Use_Epidemiology"                                                                                                                                             
[18717] "Food_Assistance_Programs"                                                                                                                                             
[18718] "Health_Communication"                                                                                                                                                 
[18719] "Virus-Cell_Membrane_Interaction"                                                                                                                                      
[18720] "Cytotoxic_T-Lymphocyte_Analysis"                                                                                                                                      
[18721] "Ubiquitination"                                                                                                                                                       
[18722] "DNA_Folding"                                                                                                                                                          
[18723] "Dominant_Negative_Receptor"                                                                                                                                           
[18724] "Tumor_Angiogenesis"                                                                                                                                                   
[18725] "Electrophoretic_Mobility_Shift_Assay"                                                                                                                                 
[18726] "Electrospray_Ionization"                                                                                                                                              
[18727] "Health_Promotion_and_Education"                                                                                                                                       
[18728] "Host-Tumor_Interaction"                                                                                                                                               
[18729] "Infection_Control_Nursing"                                                                                                                                            
[18730] "Information_and_Communication_Theory"                                                                                                                                 
[18731] "Interfacial_Phenomena"                                                                                                                                                
[18732] "Learning"                                                                                                                                                             
[18733] "Marriage_and_Family"                                                                                                                                                  
[18734] "Medical_Sciences_Clinical_Other"                                                                                                                                      
[18735] "Molecular_and_Cellular_Biology"                                                                                                                                       
[18736] "Natural_Products_Chemistry"                                                                                                                                           
[18737] "Pathway_Analysis"                                                                                                                                                     
[18738] "Neural_Development"                                                                                                                                                   
[18739] "Neurological_Nursing"                                                                                                                                                 
[18740] "Not_Defined"                                                                                                                                                          
[18741] "Nuclear_Radiochemistry"                                                                                                                                               
[18742] "Nursing_Information_System"                                                                                                                                           
[18743] "Retrovirology_Other"                                                                                                                                                  
[18744] "Sensory_and_Communicative_Sciences_Other"                                                                                                                             
[18745] "Stress_and_Coping"                                                                                                                                                    
[18746] "Adjuvanticity"                                                                                                                                                        
[18747] "Admixture"                                                                                                                                                            
[18748] "B-Cell_Proliferation"                                                                                                                                                 
[18749] "B-Lymphoma_Development"                                                                                                                                               
[18750] "Cancer_Cell_Growth"                                                                                                                                                   
[18751] "Cancer_Cell_Growth_Regulation"                                                                                                                                        
[18752] "Candidate_Disease_Gene"                                                                                                                                               
[18753] "Carcinogen_Metabolism"                                                                                                                                                
[18754] "Resistance"                                                                                                                                                           
[18755] "Carcinogen_Resistance"                                                                                                                                                
[18756] "Cell_Energetics"                                                                                                                                                      
[18757] "Cellular_Tropism"                                                                                                                                                     
[18758] "Chromosome_Condensation"                                                                                                                                              
[18759] "Equilibrium_Centrifugation"                                                                                                                                           
[18760] "Chemical_Interference"                                                                                                                                                
[18761] "Complexes"                                                                                                                                                            
[18762] "Computational_Chemistry_Statistics"                                                                                                                                   
[18763] "Nucleotide_Biochemistry"                                                                                                                                              
[18764] "Nuclei_Structure_Function"                                                                                                                                            
[18765] "Disease_Association"                                                                                                                                                  
[18766] "Nucleotide_Metabolism"                                                                                                                                                
[18767] "Mineral_and_Electrolyte_Metabolism"                                                                                                                                   
[18768] "Lipid-Lipoprotein-Membrane_Constituent_Metabolism"                                                                                                                    
[18769] "Amino_Acid-Peptide-Protein_Metabolism"                                                                                                                                
[18770] "Docking"                                                                                                                                                              
[18771] "Membrane_Structure_and_Function"                                                                                                                                      
[18772] "DRB_Gene"                                                                                                                                                             
[18773] "Membrane_Structure_Transport_Phenomena"                                                                                                                               
[18774] "Drug_Efflux"                                                                                                                                                          
[18775] "Drug_Transport"                                                                                                                                                       
[18776] "Eye_Development"                                                                                                                                                      
[18777] "Nucleotide_Synthesis"                                                                                                                                                 
[18778] "Nucleocytoplasmic_Transport"                                                                                                                                          
[18779] "G1-S_Restriction_Point"                                                                                                                                               
[18780] "GATA-Binding_Protein"                                                                                                                                                 
[18781] "Genetic_Algorithm"                                                                                                                                                    
[18782] "Genotoxic_Stress"                                                                                                                                                     
[18783] "N-Myristoylation"                                                                                                                                                     
[18784] "N-Myristoyltransferase-2"                                                                                                                                             
[18785] "Sporadic_Breast_Tumor_Mutation"                                                                                                                                       
[18786] "Multiparametric_Analysis"                                                                                                                                             
[18787] "mRNA_Export"                                                                                                                                                          
[18788] "Migration_Assays"                                                                                                                                                     
[18789] "Metal_Ion_Binding"                                                                                                                                                    
[18790] "Hepatocarcinogenesis"                                                                                                                                                 
[18791] "Metal_Carcinogenesis"                                                                                                                                                 
[18792] "Membrane_Protein_Traffic"                                                                                                                                             
[18793] "Membrane_Biology"                                                                                                                                                     
[18794] "Mammary_Tumorigenesis"                                                                                                                                                
[18795] "Histone-H2AX"                                                                                                                                                         
[18796] "HL60"                                                                                                                                                                 
[18797] "HU_Protein"                                                                                                                                                           
[18798] "Human_Pathology"                                                                                                                                                      
[18799] "Malignant_Conversion"                                                                                                                                                 
[18800] "K-562"                                                                                                                                                                
[18801] "Leukocyte_Trafficking"                                                                                                                                                
[18802] "Keratinocyte_Differentiation"                                                                                                                                         
[18803] "Volunteer_Group"                                                                                                                                                      
[18804] "Resource_Development"                                                                                                                                                 
[18805] "Media"                                                                                                                                                                
[18806] "Lung_Development"                                                                                                                                                     
[18807] "Infectious_Disease_Immunology"                                                                                                                                        
[18808] "Business_Commerce_Fiscal_Consultation"                                                                                                                                
[18809] "Red_Blood_Cell_Structure_Function_Metabolism"                                                                                                                         
[18810] "Environmental_and_Occupational_Exposure"                                                                                                                              
[18811] "Blood_and_Blood_Products"                                                                                                                                             
[18812] "DNA_Modification_Process"                                                                                                                                             
[18813] "CAT_Gene"                                                                                                                                                             
[18814] "Nucleic_Acid_Biochemistry_Enzymology"                                                                                                                                 
[18815] "Psychiatry_Other"                                                                                                                                                     
[18816] "Allogenicity"                                                                                                                                                         
[18817] "Toxicology_Other"                                                                                                                                                     
[18818] "Miscellaneous_Chemistry_Terms"                                                                                                                                        
[18819] "Vaccine_Development_Total"                                                                                                                                            
[18820] "Scientific_Advances_and_Accomplishments"                                                                                                                              
[18821] "Calendars"                                                                                                                                                            
[18822] "Specialized_Programs_of_Research_Excellence"                                                                                                                          
[18823] "Contractor"                                                                                                                                                           
[18824] "Educational_Materials"                                                                                                                                                
[18825] "Employment_Opportunities"                                                                                                                                             
[18826] "Form"                                                                                                                                                                 
[18827] "Funding_Applicant"                                                                                                                                                    
[18828] "Gifts_and_Donations"                                                                                                                                                  
[18829] "Home_Page"                                                                                                                                                            
[18830] "Industry_Collaboration"                                                                                                                                               
[18831] "Industry_Collaborators"                                                                                                                                               
[18832] "Links_List"                                                                                                                                                           
[18833] "Research_Project_Summaries"                                                                                                                                           
[18834] "Rapid_Access_to_Intervention_Development"                                                                                                                             
[18835] "Recently_Cleared_Concept"                                                                                                                                             
[18836] "Program_Review_Group_Report"                                                                                                                                          
[18837] "Grant_Review_Process"                                                                                                                                                 
[18838] "Spanish-Language_Documents"                                                                                                                                           
[18839] "Medical_Image"                                                                                                                                                        
[18840] "G-Banding"                                                                                                                                                            
[18841] "R-Banding"                                                                                                                                                            
[18842] "Culturing_in_vitro_Vertebrate_Tissue"                                                                                                                                 
[18843] "Culturing_in_vitro_Vertebrate_Cell"                                                                                                                                   
[18844] "Certificate_of_Confidentiality"                                                                                                                                       
[18845] "Expanded_Authorities"                                                                                                                                                 
[18846] "Facilities_and_Administrative_Costs"                                                                                                                                  
[18847] "Green_Card"                                                                                                                                                           
[18848] "Institution_Supplementation"                                                                                                                                          
[18849] "Institutional_Animal_Care_and_Use_Committee"                                                                                                                          
[18850] "Just-in-time-concept"                                                                                                                                                 
[18851] "Mentor_s_Statement"                                                                                                                                                   
[18852] "Non-Citizen_National"                                                                                                                                                 
[18853] "Population_Sciences"                                                                                                                                                  
[18854] "Professional_Degree_Clinically_Equivalent"                                                                                                                            
[18855] "Reapplication"                                                                                                                                                        
[18856] "NCI_Scholars_Program"                                                                                                                                                 
[18857] "Senior_Scientist"                                                                                                                                                     
[18858] "Transition_Career_Development_Award"                                                                                                                                  
[18859] "National_Research_Service_Award_for_Senior_Fellows"                                                                                                                   
[18860] "Document_Type"                                                                                                                                                        
[18861] "DNA_Biochemistry"                                                                                                                                                     
[18862] "RNA_Biochemistry"                                                                                                                                                     
[18863] "Tumorigenicity"                                                                                                                                                       
[18864] "Gender_Minority_Enrollment"                                                                                                                                           
[18865] "Underserved_Rural_Health"                                                                                                                                             
[18866] "Herpes_Total"                                                                                                                                                         
[18867] "Cancer_Centers-Subcommittee_A"                                                                                                                                        
[18868] "Basic_and_Preclinical-Subcommittee_C"                                                                                                                                 
[18869] "Clinical_Studies-Subcommittee_D"                                                                                                                                      
[18870] "Prevention_and_Control-Subcommittee_E"                                                                                                                                
[18871] "Manpower_and_Training-Subcommittee_F"                                                                                                                                 
[18872] "Education-Subcommittee_G"                                                                                                                                             
[18873] "Clinical_Groups-Subcommittee_H"                                                                                                                                       
[18874] "Terminated_Comprehensiveness-Subcommittee_B"                                                                                                                          
[18875] "NCI_Director_s_Working_Groups"                                                                                                                                        
[18876] "Program_Review_Groups"                                                                                                                                                
[18877] "Breast_Cancer_Progress_Review_Group"                                                                                                                                  
[18878] "Prostate_Cancer_Progress_Review_Group"                                                                                                                                
[18879] "Other_Working_Groups"                                                                                                                                                 
[18880] "AIDS-Related_Malignancies_Working_Group"                                                                                                                              
[18881] "Contingency_Fund"                                                                                                                                                     
[18882] "Early_Detection_Branch"                                                                                                                                               
[18883] "Cancer_Genetics_Working_Group"                                                                                                                                        
[18884] "Developmental_Diagnostics_Working_Group"                                                                                                                              
[18885] "Preclinical_Models_for_Human_Cancers_Working_Group"                                                                                                                   
[18886] "Imaging_Sciences_Working_Group"                                                                                                                                       
[18887] "Developmental_Therapeutics_Program_Review_Group"                                                                                                                      
[18888] "Cancer_Centers_Program_Review_Group"                                                                                                                                  
[18889] "Cancer_Control_Program_Review_Group"                                                                                                                                  
[18890] "Clinical_Trials_Program_Review_Group"                                                                                                                                 
[18891] "Prevention_Program_Review_Groups"                                                                                                                                     
[18892] "Sequence-Specific_DNA_Binding_Protein"                                                                                                                                
[18893] "JUN_Gene"                                                                                                                                                             
[18894] "FOS_Gene"                                                                                                                                                             
[18895] "Vertebrate_Biology"                                                                                                                                                   
[18896] "Recombination_Repair"                                                                                                                                                 
[18897] "UV_Systematic_Effects"                                                                                                                                                
[18898] "Metabolic_Process"                                                                                                                                                    
[18899] "High_Prevalence"                                                                                                                                                      
[18900] "Training_and_Infrastructure"                                                                                                                                          
[18901] "Radiotherapy_Medical_Specialty"                                                                                                                                       
[18902] "Cancer_Gene"                                                                                                                                                          
[18903] "Compact_Disc-Interactive"                                                                                                                                             
[18904] "Desktop_Video"                                                                                                                                                        
[18905] "Digital_Video-Interactive"                                                                                                                                            
[18906] "Integrated_Learning_System"                                                                                                                                           
[18907] "Interactive_Communication"                                                                                                                                            
[18908] "Palmtop"                                                                                                                                                              
[18909] "Smart_Card"                                                                                                                                                           
[18910] "Z-DNA_Binding_Protein"                                                                                                                                                
[18911] "Education_of_Caregivers"                                                                                                                                              
[18912] "Alpha_Particle_Emitter"                                                                                                                                               
[18913] "Epidemiology_of_Childhood_Malignancies"                                                                                                                               
[18914] "Prediction_of_Radiation_Response"                                                                                                                                     
[18915] "Baculovirus_Expression_System"                                                                                                                                        
[18916] "HIV-1_Load"                                                                                                                                                           
[18917] "Microtubule_Depolymerization"                                                                                                                                         
[18918] "Microtubule_Polymerization"                                                                                                                                           
[18919] "Tumor_Oxygenation"                                                                                                                                                    
[18920] "Cocrystallography"                                                                                                                                                    
[18921] "Cell_Cycle_Arrest"                                                                                                                                                    
[18922] "Cell_Ontogeny"                                                                                                                                                        
[18923] "Sister_Chromatid_Exchange_Assay"                                                                                                                                      
[18924] "Nuclear_Transfer"                                                                                                                                                     
[18925] "Tissue-Specific_Gene_Expression"                                                                                                                                      
[18926] "Tissue-Specific_Splicing"                                                                                                                                             
[18927] "Whole-Body_Scintigraphy"                                                                                                                                              
[18928] "Ectopic_Expression"                                                                                                                                                   
[18929] "Isozyme"                                                                                                                                                              
[18930] "Viral_Function"                                                                                                                                                       
[18931] "Virus-Induced_Membrane_Fusion"                                                                                                                                        
[18932] "Membrane_Fusion_Activity"                                                                                                                                             
[18933] "Molecular_Toxicology"                                                                                                                                                 
[18934] "Bistrand_Abasic_Site"                                                                                                                                                 
[18935] "Fiber_FISH"                                                                                                                                                           
[18936] "GIS_Imaging"                                                                                                                                                          
[18937] "Random_Peptide_Synthesis"                                                                                                                                             
[18938] "Nutritional_Carcinogenesis"                                                                                                                                           
[18939] "Multidimensional_NMR_Techniques"                                                                                                                                      
[18940] "Lytic_Phase"                                                                                                                                                          
[18941] "Direct_Costs"                                                                                                                                                         
[18942] "Protein_Phosphatase_2A"                                                                                                                                               
[18943] "Restriction_Enzyme_Analysis"                                                                                                                                          
[18944] "Run-On_Assays"                                                                                                                                                        
[18945] "Embryonic_Lethal_Mutation"                                                                                                                                            
[18946] "Rat-1"                                                                                                                                                                
[18947] "DNA-Mediated_Gene_Transfer"                                                                                                                                           
[18948] "Liposome-Mediated_Gene_Transfer"                                                                                                                                      
[18949] "Antibody_Repertoire"                                                                                                                                                  
[18950] "Atomic_Resolution_X-Ray_Crystallography"                                                                                                                              
[18951] "Viral_Pathogenesis"                                                                                                                                                   
[18952] "Whole_Genome_PCR"                                                                                                                                                     
[18953] "Diagnostic_Factor"                                                                                                                                                    
[18954] "Direct_Cost_Greater_Than_500K_Per_Year"                                                                                                                               
[18955] "Gender_Minority_Projection"                                                                                                                                           
[18956] "Not_Otherwise_Specified"                                                                                                                                              
[18957] "Nutritional_Epidemiology"                                                                                                                                             
[18958] "Occupational_Environmental_Epidemiology"                                                                                                                              
[18959] "Tissue_Paraffin"                                                                                                                                                      
[18960] "Cell_Cycle_Regulation"                                                                                                                                                
[18961] "T-Cell_Proliferation"                                                                                                                                                 
[18962] "Replication_Error"                                                                                                                                                    
[18963] "Breast_Cancer_Prognostic_Factor"                                                                                                                                      
[18964] "Board_Certification"                                                                                                                                                  
[18965] "American_College_of_Radiology_Imaging_Network"                                                                                                                        
[18966] "Office_of_Technology_and_Industrial_Relations"                                                                                                                        
[18967] "Biochemistry_and_Cellular_Biology"                                                                                                                                    
[18968] "Biology_of_HIV_Transmission"                                                                                                                                          
[18969] "Comparative_Carcinogenesis"                                                                                                                                           
[18970] "Double_Strand_Break_Repair"                                                                                                                                           
[18971] "Functional_Imaging"                                                                                                                                                   
[18972] "Immunodeficiency_and_Cancer"                                                                                                                                          
[18973] "Molecular_Immunology"                                                                                                                                                 
[18974] "Legislative_Liaison"                                                                                                                                                  
[18975] "Mammalian_Genetics"                                                                                                                                                   
[18976] "Manpower_and_Training"                                                                                                                                                
[18977] "Neuropharmacology_and_Toxicology"                                                                                                                                     
[18978] "James_A_Shannon_Directors_Award"                                                                                                                                      
[18979] "Yeast_Model_System"                                                                                                                                                   
[18980] "Signal_Transducer_and_Activator_of_Transcription"                                                                                                                     
[18981] "RNA_Metabolism_Processing_and_Transport"                                                                                                                              
[18982] "GFP-NIC96"                                                                                                                                                            
[18983] "Metastasize"                                                                                                                                                          
[18984] "Clinical_Oncology"                                                                                                                                                    
[18985] "Biomarkers_and_Prevention_Research_Branch"                                                                                                                            
[18986] "Scientific_Evaluation"                                                                                                                                                
[18987] "Cytoskeleton_Tumor_Biology"                                                                                                                                           
[18988] "Neural_Growth_Development_Degeneration"                                                                                                                               
[18989] "DNA_Replication_and_Repair"                                                                                                                                           
[18990] "Education_and_Outreach"                                                                                                                                               
[18991] "Radiation-Induced_Gene_Expression"                                                                                                                                    
[18992] "Immune_Targeting"                                                                                                                                                     
[18993] "Leukocyte_Cell_Biology"                                                                                                                                               
[18994] "Lymphocyte_Function"                                                                                                                                                  
[18995] "NCI_Strategic_Planning"                                                                                                                                               
[18996] "BRCA1_Mutation"                                                                                                                                                       
[18997] "BRCA2_Mutation"                                                                                                                                                       
[18998] "Five_Prime_Nucleotidase"                                                                                                                                              
[18999] "Classical_Mechanics"                                                                                                                                                  
[19000] "Clone-Based_Physical_Mapping"                                                                                                                                         
[19001] "Clusters_of_Orthologous_Groups_of_Genes"                                                                                                                              
[19002] "Dideoxy_Chain_Termination_DNA_Sequencing"                                                                                                                             
[19003] "Founder_Generation"                                                                                                                                                   
[19004] "Gene_Combinations"                                                                                                                                                    
[19005] "Genotypic_Risk_Ratio"                                                                                                                                                 
[19006] "Large-Scale_Sequencing"                                                                                                                                               
[19007] "Shotgun_Sequencing"                                                                                                                                                   
[19008] "Linkage_Disequilibrium_Mapping"                                                                                                                                       
[19009] "Phylogenetic_Patterns"                                                                                                                                                
[19010] "Protein_Dynamics"                                                                                                                                                     
[19011] "Quantum_Mechanics"                                                                                                                                                    
[19012] "Shotgun_Sequence_Assembly"                                                                                                                                            
[19013] "Statistical_Mechanics"                                                                                                                                                
[19014] "Whole-Genome_Shotgun_Sequencing"                                                                                                                                      
[19015] "YAC-Based_STS-Content_Mapping"                                                                                                                                        
[19016] "YAC_Cloning"                                                                                                                                                          
[19017] "Signal_Induction"                                                                                                                                                     
[19018] "Recombinant_Haplotype"                                                                                                                                                
[19019] "Radioactive_Sequencing"                                                                                                                                               
[19020] "System_for_Public_Use"                                                                                                                                                
[19021] "School_Drop-Outs"                                                                                                                                                     
[19022] "Breast_Cancer_Surveillance_Consortium"                                                                                                                                
[19023] "Lifetime_Risk"                                                                                                                                                        
[19024] "Cell-Cell_Adhesion"                                                                                                                                                   
[19025] "Angiogenic_Switch"                                                                                                                                                    
[19026] "Breast_Cancer_Risk_Assessment_Tool"                                                                                                                                   
[19027] "Age_at_Menarche"                                                                                                                                                      
[19028] "Age_at_First_Live_Birth"                                                                                                                                              
[19029] "Tobacco_Research_Implementation_Group"                                                                                                                                
[19030] "Glioma_Marker_Network"                                                                                                                                                
[19031] "Vasculostatin"                                                                                                                                                        
[19032] "Histone_Deacetylase-1"                                                                                                                                                
[19033] "Histone_Deacetylase-3"                                                                                                                                                
[19034] "Histone_Deacetylase-4"                                                                                                                                                
[19035] "Scaffold_Attachment_Factor-B"                                                                                                                                         
[19036] "XRCC1_Gene"                                                                                                                                                           
[19037] "DNA_Repair_Gene"                                                                                                                                                      
[19038] "APEX1_Gene"                                                                                                                                                           
[19039] "Histone_Deacetylase-5"                                                                                                                                                
[19040] "Histone_Deacetylase-6"                                                                                                                                                
[19041] "Biostatistical_Methods"                                                                                                                                               
[19042] "Dietary_Questionnaires"                                                                                                                                               
[19043] "Mutation_Fixation"                                                                                                                                                    
[19044] "Personal_Behavior"                                                                                                                                                    
[19045] "Training_of_Investigators"                                                                                                                                            
[19046] "Biology_of_Aging"                                                                                                                                                     
[19047] "Clonal_Evolution"                                                                                                                                                     
[19048] "Communication_Tools"                                                                                                                                                  
[19049] "Exogenous_Factors"                                                                                                                                                    
[19050] "Organ_Model"                                                                                                                                                          
[19051] "Predictive_Cancer_Model"                                                                                                                                              
[19052] "Cancer_Model"                                                                                                                                                         
[19053] "Tissue_Model"                                                                                                                                                         
[19054] "Endogenous_Factors"                                                                                                                                                   
[19055] "Risk_Reduction"                                                                                                                                                       
[19056] "Audiovisual_Material"                                                                                                                                                 
[19057] "Sites_of_Care_Delivery"                                                                                                                                               
[19058] "Tissue_Sample"                                                                                                                                                        
[19059] "Cancer_Advocacy"                                                                                                                                                      
[19060] "Cancer_Gene_Mutation"                                                                                                                                                 
[19061] "Cancer_Patient"                                                                                                                                                       
[19062] "Cancer_Death_Rates"                                                                                                                                                   
[19063] "Cigar_Smoking"                                                                                                                                                        
[19064] "Clinical_Oncology_Supplement_K12"                                                                                                                                     
[19065] "Clinical_Research_Curriculum_Award"                                                                                                                                   
[19066] "Prostaglandin-Endoperoxide_Synthase-1"                                                                                                                                
[19067] "Dietary_Practices"                                                                                                                                                    
[19068] "AIDS_Malignancy_Consortium"                                                                                                                                           
[19069] "AIDS_Oncology_Research_Handbook"                                                                                                                                      
[19070] "American_College_of_Surgeons"                                                                                                                                         
[19071] "Environmentally_Produced_Gene_Alteration"                                                                                                                             
[19072] "Professional_Organization_or_Group"                                                                                                                                   
[19073] "American_College_of_Surgeons_Oncology_Group"                                                                                                                          
[19074] "Oncology_Group"                                                                                                                                                       
[19075] "Bypass_Budget"                                                                                                                                                        
[19076] "Cancer_Center_Support_Grant"                                                                                                                                          
[19077] "Cancer_Cluster"                                                                                                                                                       
[19078] "Cancer_Education_Grant_Program_CEGP"                                                                                                                                  
[19079] "Cancer_Genetics_and_Epidemiology_Fellowship_Program"                                                                                                                  
[19080] "Cancer_Genetics_Education_Program"                                                                                                                                    
[19081] "Cancer_Research_Network"                                                                                                                                              
[19082] "CancerFax"                                                                                                                                                            
[19083] "CancerLit"                                                                                                                                                            
[19084] "Cancer_Grant_Supplements_P30"                                                                                                                                         
[19085] "Childrens_Cancer_Group"                                                                                                                                               
[19086] "Clinical_Cancer_Center"                                                                                                                                               
[19087] "Clinical_Intramural_Research_Award"                                                                                                                                   
[19088] "Colorectal_Cancer_Surveillance_Consortium"                                                                                                                            
[19089] "Colorectal_Cancer_Surveillance_Health_Information_System"                                                                                                             
[19090] "Comprehensive_Cancer_Center"                                                                                                                                          
[19091] "Comprehensive_Minority_Biomedical_Program"                                                                                                                            
[19092] "FDA_Modernization_Act_of_1997"                                                                                                                                        
[19093] "Continuing_Umbrella_of_Research_Experience_for_Underserved_Minorities_Program"                                                                                        
[19094] "Cooking_Practices"                                                                                                                                                    
[19095] "Grants_Applications"                                                                                                                                                  
[19096] "Grant_Review"                                                                                                                                                         
[19097] "Heightened_Cancer_Risk"                                                                                                                                               
[19098] "Cooperative_Agreements_U-Series"                                                                                                                                      
[19099] "Cooperative_Research_and_Development_Agreement"                                                                                                                       
[19100] "Epidemiology_and_Biostatistics_Fellowship"                                                                                                                            
[19101] "Established_Investigator_in_Cancer_Prevention_Control_and_Population_Sciences_Award_K05"                                                                              
[19102] "European_Organization_for_Research_and_Treatment_of_Cancer"                                                                                                           
[19103] "Gamma_Particles"                                                                                                                                                      
[19104] "Genetic_Status"                                                                                                                                                       
[19105] "Hot_Spot"                                                                                                                                                             
[19106] "Hormonal_Risk_Factor"                                                                                                                                                 
[19107] "Human_Cancer_Pathology"                                                                                                                                               
[19108] "Imaging_Device"                                                                                                                                                       
[19109] "Laboratory_of_Population_Genetics"                                                                                                                                    
[19110] "Interactive_Kiosk"                                                                                                                                                    
[19111] "Mouse_Models_of_Human_Cancer_Consortium"                                                                                                                              
[19112] "National_Action_Plan_on_Breast_Cancer"                                                                                                                                
[19113] "National_Health_Interview_Survey"                                                                                                                                     
[19114] "National_Institute_of_Allergy_and_Infectious_Disease"                                                                                                                 
[19115] "National_Institute_of_Child_Health_and_Human_Development"                                                                                                             
[19116] "National_Institute_of_Dental_Research"                                                                                                                                
[19117] "National_Institute_of_Digestive_Diseases_and_Kidney_Disorders"                                                                                                        
[19118] "National_Institute_of_Drug_Abuse"                                                                                                                                     
[19119] "National_Institute_of_Nursing_Research"                                                                                                                               
[19120] "Mentored_Clinical_Oncology_Award"                                                                                                                                     
[19121] "National_Wilms_Tumor_Study_Group"                                                                                                                                     
[19122] "Mentored_Clinical_Scientist_Award"                                                                                                                                    
[19123] "Network_for_Research_on_Cancer_in_Children"                                                                                                                           
[19124] "Mentored_Patient-Oriented_Research_Career_Development_Award"                                                                                                          
[19125] "NIH_Center_for_Scientific_Review"                                                                                                                                     
[19126] "NIH_Office_of_AIDS_Research"                                                                                                                                          
[19127] "NIH_Vaccine_Research_Center"                                                                                                                                          
[19128] "Number_of_First_Degree_Relatives_Affected"                                                                                                                            
[19129] "Mid-Career_Clinical_Scientist_Award"                                                                                                                                  
[19130] "Midcareer_Investigator_Award_in_Patient-Oriented_Research"                                                                                                            
[19131] "Molecular_Analysis"                                                                                                                                                   
[19132] "Molecular_Profiling"                                                                                                                                                  
[19133] "NCI_Executive_Committee"                                                                                                                                              
[19134] "Office_for_Protection_from_Research_Risks"                                                                                                                            
[19135] "Office_of_Cancer_Survivorship"                                                                                                                                        
[19136] "Pediatric_Cancer_Care_Network"                                                                                                                                        
[19137] "Pediatric_Oncology_Group"                                                                                                                                             
[19138] "Polyvalence"                                                                                                                                                          
[19139] "Radiation_Therapy_Oncology_Group"                                                                                                                                     
[19140] "Small_Animal_Imaging_Systems"                                                                                                                                         
[19141] "Study_Section"                                                                                                                                                        
[19142] "Surveillance_Implementation_Group"                                                                                                                                    
[19143] "Task_Force_on_Environmental_Health_Safety_Risks_to_Children"                                                                                                          
[19144] "Tumor-Secreted_Protein"                                                                                                                                               
[19145] "Uncertain_Risk"                                                                                                                                                       
[19146] "Research_Career_Programs_K-Series"                                                                                                                                    
[19147] "Warren_G_Magnuson_Clinical_Center"                                                                                                                                    
[19148] "Population_Scientist_Supplement"                                                                                                                                      
[19149] "Underrepresented_Minority"                                                                                                                                            
[19150] "Tumor_Subtype"                                                                                                                                                        
[19151] "Cancer_Prevention_Control_and_Population_Sciences_Career_Development_Award_K07"                                                                                       
[19152] "Program_Reviews"                                                                                                                                                      
[19153] "Training_Program_for_Cancer_Prevention_and_Control_Scientists"                                                                                                        
[19154] "Therapeutic_Studies"                                                                                                                                                  
[19155] "Societal_Factors"                                                                                                                                                     
[19156] "Smoking_Status"                                                                                                                                                       
[19157] "Chromatin_Remodeling"                                                                                                                                                 
[19158] "Splice-Site_Mutation"                                                                                                                                                 
[19159] "DRD2-A1_Allele"                                                                                                                                                       
[19160] "Yeast_Protein_Complex"                                                                                                                                                
[19161] "NURF"                                                                                                                                                                 
[19162] "RSC"                                                                                                                                                                  
[19163] "SWI2-SNF2_Protein"                                                                                                                                                    
[19164] "SAGA"                                                                                                                                                                 
[19165] "CHRAC"                                                                                                                                                                
[19166] "Model_Genes_and_Proteins"                                                                                                                                             
[19167] "SWI1"                                                                                                                                                                 
[19168] "Swi3p"                                                                                                                                                                
[19169] "SNF6"                                                                                                                                                                 
[19170] "DRD2-A2_Allele"                                                                                                                                                       
[19171] "Second_Degree_Relative"                                                                                                                                               
[19172] "Xenograft_Model"                                                                                                                                                      
[19173] "Immunoliposome"                                                                                                                                                       
[19174] "Drosophila_Protein_Complex"                                                                                                                                           
[19175] "TdT-Mediated_dUTP_Nick_End_Labeling_Assay"                                                                                                                            
[19176] "G1_Arrest"                                                                                                                                                            
[19177] "HSV-Tk_Gene"                                                                                                                                                          
[19178] "Cellular_Retinoic_Acid_Binding_Protein"                                                                                                                               
[19179] "cDNA_Array"                                                                                                                                                           
[19180] "Warburg_Effect"                                                                                                                                                       
[19181] "CpG_Island_Methylator_Phenotype"                                                                                                                                      
[19182] "Allelotyping"                                                                                                                                                         
[19183] "Allelotype_Analysis"                                                                                                                                                  
[19184] "Polyamine_Catabolism"                                                                                                                                                 
[19185] "Epithelial_Cell_Aggregation_and_Separation"                                                                                                                           
[19186] "Short_Oligonucleotide_Mass_Analysis"                                                                                                                                  
[19187] "Brightfield_Microscopy"                                                                                                                                               
[19188] "Metaphase_Spread"                                                                                                                                                     
[19189] "G2-M_Arrest"                                                                                                                                                          
[19190] "Co-Immunoprecipitation"                                                                                                                                               
[19191] "Tissue_Recombination"                                                                                                                                                 
[19192] "Nuclear_Extract"                                                                                                                                                      
[19193] "Dorsal_Skinfold_Window_Chamber_Model"                                                                                                                                 
[19194] "Matrigel_Artificial_Basement_Membrane_Model"                                                                                                                          
[19195] "Gelatin_Zymography"                                                                                                                                                   
[19196] "Cytosolic_Phospholipase-A2"                                                                                                                                           
[19197] "hSWI-SNF_Protein"                                                                                                                                                     
[19198] "BAF155"                                                                                                                                                               
[19199] "BAF170"                                                                                                                                                               
[19200] "BAF57"                                                                                                                                                                
[19201] "SWP73"                                                                                                                                                                
[19202] "BAF60A"                                                                                                                                                               
[19203] "BAF60b"                                                                                                                                                               
[19204] "BAF60C"                                                                                                                                                               
[19205] "BRG1_Protein"                                                                                                                                                         
[19206] "hBRM"                                                                                                                                                                 
[19207] "SWP82"                                                                                                                                                                
[19208] "SWP61"                                                                                                                                                                
[19209] "SWP59"                                                                                                                                                                
[19210] "SWP29"                                                                                                                                                                
[19211] "Basal_Transcription_Factor"                                                                                                                                           
[19212] "dSWI-SNF_Protein"                                                                                                                                                     
[19213] "SWI2-SNF2_Family_Protein"                                                                                                                                             
[19214] "Swh3p"                                                                                                                                                                
[19215] "Sth1p"                                                                                                                                                                
[19216] "SNR1"                                                                                                                                                                 
[19217] "SNF2L1"                                                                                                                                                               
[19218] "SNF2H"                                                                                                                                                                
[19219] "SNF11"                                                                                                                                                                
[19220] "Sfh1"                                                                                                                                                                 
[19221] "Rsc6"                                                                                                                                                                 
[19222] "OSA"                                                                                                                                                                  
[19223] "MOIRA_Gene_Product"                                                                                                                                                   
[19224] "Mediator_of_Activation"                                                                                                                                               
[19225] "BRAHMA"                                                                                                                                                               
[19226] "PRC1"                                                                                                                                                                 
[19227] "Polycomb"                                                                                                                                                             
[19228] "Polyhomeotic"                                                                                                                                                         
[19229] "Posterior_Sex_Combs_Protein"                                                                                                                                          
[19230] "Sex_Combs_on_Midleg_Protein"                                                                                                                                          
[19231] "E-RC1"                                                                                                                                                                
[19232] "SMARCC1_Gene"                                                                                                                                                         
[19233] "SMARCC2_Gene"                                                                                                                                                         
[19234] "SMARCE1_Gene"                                                                                                                                                         
[19235] "SMARCD1_Gene"                                                                                                                                                         
[19236] "SMARCD2_Gene"                                                                                                                                                         
[19237] "SMARCD3_Gene"                                                                                                                                                         
[19238] "SMARCA4_Gene"                                                                                                                                                         
[19239] "SMARCA2_Gene"                                                                                                                                                         
[19240] "SWI-SNF-Related_Gene"                                                                                                                                                 
[19241] "ERCC6_Gene"                                                                                                                                                           
[19242] "SMARCA3_Gene"                                                                                                                                                         
[19243] "SMARCA5_Gene"                                                                                                                                                         
[19244] "SMARCA1_Gene"                                                                                                                                                         
[19245] "mSin3"                                                                                                                                                                
[19246] "Nuclear_Receptor_Coactivator-4"                                                                                                                                       
[19247] "TIP60"                                                                                                                                                                
[19248] "Nuclear_Receptor_Coactivator-2"                                                                                                                                       
[19249] "P_CIP"                                                                                                                                                                
[19250] "TRAP_Complex"                                                                                                                                                         
[19251] "Nuclear_Receptor_Co-Repressor-2"                                                                                                                                      
[19252] "AML1-ETO_Chimeric_Protein"                                                                                                                                            
[19253] "MAD_MXI1"                                                                                                                                                             
[19254] "Gcn5p"                                                                                                                                                                
[19255] "DRD2_Gene"                                                                                                                                                            
[19256] "Miscellaneous_Molecular_Biology_Terms"                                                                                                                                
[19257] "National_Center_for_Complementary_and_Alternative_Medicine"                                                                                                           
[19258] "Dnase-I_Footprinting"                                                                                                                                                 
[19259] "Biochemical_Reaction"                                                                                                                                                 
[19260] "Proteolytic_Processing"                                                                                                                                               
[19261] "Dimerization"                                                                                                                                                         
[19262] "Protein_Biochemistry"                                                                                                                                                 
[19263] "Post-Translational_Regulation"                                                                                                                                        
[19264] "Enhanced_Spiral_CT"                                                                                                                                                   
[19265] "Phased_Spiral_CT"                                                                                                                                                     
[19266] "Two-Phase_Spiral_CT"                                                                                                                                                  
[19267] "Triple-Phase_Spiral_CT"                                                                                                                                               
[19268] "Quadruple_Phase_Spiral_CT"                                                                                                                                            
[19269] "Portal_Venous_Phase_Spiral_CT"                                                                                                                                        
[19270] "Arterial_Phase_Spiral_CT"                                                                                                                                             
[19271] "Equilibrium_Phase_Spiral_CT"                                                                                                                                          
[19272] "Subsecond_Spiral_CT"                                                                                                                                                  
[19273] "Dynamic_Spiral_CT"                                                                                                                                                    
[19274] "Incremental_Spiral_CT"                                                                                                                                                
[19275] "Retrotransposition"                                                                                                                                                   
[19276] "SAFB_Gene"                                                                                                                                                            
[19277] "SRC_Gene"                                                                                                                                                             
[19278] "SIL-SCL_Chimeric_Protein"                                                                                                                                             
[19279] "Megakaryocyte_Proliferation"                                                                                                                                          
[19280] "Thyroid_Hormone_Receptor_Alpha-1"                                                                                                                                     
[19281] "Dynamic_Enhanced_CT"                                                                                                                                                  
[19282] "Tissue_Microarray"                                                                                                                                                    
[19283] "Tissue_Expediter"                                                                                                                                                     
[19284] "Principal_Investigator"                                                                                                                                               
[19285] "Postdoctoral_Fellow"                                                                                                                                                  
[19286] "Venous_Phase_Spiral_CT"                                                                                                                                               
[19287] "Subsecond_Spiral_CT_Scanner"                                                                                                                                          
[19288] "Apoptosis_Regulator"                                                                                                                                                  
[19289] "FGFR1_Gene"                                                                                                                                                           
[19290] "Fibroblast_Growth_Factor_Receptor_Family_Gene"                                                                                                                        
[19291] "FGFR2_Gene"                                                                                                                                                           
[19292] "Inhibition_of_Apoptosis"                                                                                                                                              
[19293] "AIDS-Indirect"                                                                                                                                                        
[19294] "HMGN1"                                                                                                                                                                
[19295] "MALDI-TOF_Mass_Spectrometry"                                                                                                                                          
[19296] "Alternative_Medicine_Direct"                                                                                                                                          
[19297] "Alternative_Medicine_Indirect"                                                                                                                                        
[19298] "Arctic_Research"                                                                                                                                                      
[19299] "ATP_Hydrolysis"                                                                                                                                                       
[19300] "NK-Cell_Activation"                                                                                                                                                   
[19301] "Perinatal_Carcinogenesis"                                                                                                                                             
[19302] "Perinatal_Exposure"                                                                                                                                                   
[19303] "Heparan_Sulfate_Biosynthesis"                                                                                                                                         
[19304] "Stress_Response_Signaling"                                                                                                                                            
[19305] "RET-H4_Oncoprotein"                                                                                                                                                   
[19306] "Limb_Development"                                                                                                                                                     
[19307] "Epithelial_Cell_Proliferation"                                                                                                                                        
[19308] "Bacteriophage_Genetics"                                                                                                                                               
[19309] "Angiotropin"                                                                                                                                                          
[19310] "Transmembrane_Transport"                                                                                                                                              
[19311] "MYC-Associated_Factor-X"                                                                                                                                              
[19312] "Immunoglobulin-Mediated_Cell_Signaling"                                                                                                                               
[19313] "Spleen_Development"                                                                                                                                                   
[19314] "RET_Oncoprotein"                                                                                                                                                      
[19315] "Myeloproliferation"                                                                                                                                                   
[19316] "Folate_Metabolism"                                                                                                                                                    
[19317] "Quinone_Metabolism"                                                                                                                                                   
[19318] "Androgen_Metabolism"                                                                                                                                                  
[19319] "Pediatric_Brain_Tumor_Consortium"                                                                                                                                     
[19320] "Phased_Technology_Application_Award"                                                                                                                                  
[19321] "in_vivo_Cellular_and_Molecular_Imaging_Centers"                                                                                                                       
[19322] "Accelerated_Executive_Review"                                                                                                                                         
[19323] "Joining_Organizations_with_Leading_Technologies"                                                                                                                      
[19324] "Association_of_Cancer_On-line_Resources"                                                                                                                              
[19325] "Molecular_Epidemiology_of_Cancer"                                                                                                                                     
[19326] "Molecular_Fingerprint_of_Tumor"                                                                                                                                       
[19327] "Molecular_Fingerprinting_of_Tumor"                                                                                                                                    
[19328] "Molecular_Target_Discovery_Grants"                                                                                                                                    
[19329] "AXIN1_Gene"                                                                                                                                                           
[19330] "Pattern_Formation"                                                                                                                                                    
[19331] "Dorsal-Ventral_Pattern_Formation"                                                                                                                                     
[19332] "Signatures_of_Cancer_Cells"                                                                                                                                           
[19333] "Quick_Trials_Program"                                                                                                                                                 
[19334] "Biosynthetic_Chemistry"                                                                                                                                               
[19335] "NCI_Consortium_or_Network"                                                                                                                                            
[19336] "Regional_Enhancement_Center"                                                                                                                                          
[19337] "Nicotine_Inhaler"                                                                                                                                                     
[19338] "Special_Populations_Networks"                                                                                                                                         
[19339] "Structural_Biologist"                                                                                                                                                 
[19340] "NCI-Designated_Cancer_Center"                                                                                                                                         
[19341] "Transdisciplinary_Tobacco_Research_Center"                                                                                                                            
[19342] "NCI_Unconventional_Innovations_Program"                                                                                                                               
[19343] "Centers_of_Research_Excellence"                                                                                                                                       
[19344] "Common_Data_Element"                                                                                                                                                  
[19345] "Diagnostics_Validation_Network"                                                                                                                                       
[19346] "Biophysical_Process"                                                                                                                                                  
[19347] "Cancer_Progression"                                                                                                                                                   
[19348] "Organismal_Process"                                                                                                                                                   
[19349] "Sensory_Process"                                                                                                                                                      
[19350] "Cancer_Informatics_Infrastructure"                                                                                                                                    
[19351] "Clinical_Trials_Informatics_System"                                                                                                                                   
[19352] "Clinical_Data_Update_System"                                                                                                                                          
[19353] "SKI_Oncoprotein"                                                                                                                                                      
[19354] "Electromagnetism"                                                                                                                                                     
[19355] "Attributes_of_Chemicals"                                                                                                                                              
[19356] "Biological_Effect_of_Chemicals"                                                                                                                                       
[19357] "Research_Funding_Categories"                                                                                                                                          
[19358] "Performance_Status_0"                                                                                                                                                 
[19359] "Performance_Status_1"                                                                                                                                                 
[19360] "Performance_Status_5"                                                                                                                                                 
[19361] "Postdoctoral_Individual_National_Research_Service_Award"                                                                                                              
[19362] "Predoctoral_Individual_National_Research_Service_Award"                                                                                                               
[19363] "Fellowship_Programs"                                                                                                                                                  
[19364] "Extramural_Funding_Mechanisms"                                                                                                                                        
[19365] "Mentored_Research_Scientist_Development_Award"                                                                                                                        
[19366] "Research_Scientist_Award"                                                                                                                                             
[19367] "Physician_Scientist_Award_Program"                                                                                                                                    
[19368] "Career_Transition_Award"                                                                                                                                              
[19369] "Academic_Teacher_Award"                                                                                                                                               
[19370] "Clinical_Investigator_Award"                                                                                                                                          
[19371] "National_Research_Service_Awards"                                                                                                                                     
[19372] "Exploratory_Developmental_Grant"                                                                                                                                      
[19373] "Exploratory_Developmental_Grant_Phase_II"                                                                                                                             
[19374] "Center_Core_Grants"                                                                                                                                                   
[19375] "Education_Projects"                                                                                                                                                   
[19376] "National_Center_for_Research_Resources"                                                                                                                               
[19377] "Extramural_Research_Facilities_Construction_Project"                                                                                                                  
[19378] "Research_Facilities_Construction_Grants"                                                                                                                              
[19379] "Specialized_Center"                                                                                                                                                   
[19380] "Funding_Mechanisms"                                                                                                                                                   
[19381] "Funding_Opportunities"                                                                                                                                                
[19382] "Research_and_Development-Related_Contracts_N-Series"                                                                                                                  
[19383] "Ku70_Protein"                                                                                                                                                         
[19384] "Biophotonics"                                                                                                                                                         
[19385] "_14_3_3_Sigma_Gene"                                                                                                                                                   
[19386] "Flame-Broiling"                                                                                                                                                       
[19387] "Protein_Organized_by_Function"                                                                                                                                        
[19388] "Protein_Organized_by_Structure"                                                                                                                                       
[19389] "Lipoprotein"                                                                                                                                                          
[19390] "Protein_Organized_by_Location"                                                                                                                                        
[19391] "Extracellular_Protein"                                                                                                                                                
[19392] "Protein_Organized_by_Origin"                                                                                                                                          
[19393] "Cytoplasmic_Protein"                                                                                                                                                  
[19394] "Senior_Scientist_Award"                                                                                                                                               
[19395] "Fluorescence_Bronchoscopy"                                                                                                                                            
[19396] "Nuclear_Orphan_Receptor"                                                                                                                                              
[19397] "FAK_Family_Tyrosine_Kinase"                                                                                                                                           
[19398] "Population_Attributable_Risks"                                                                                                                                        
[19399] "Hematology_Other"                                                                                                                                                     
[19400] "K22_Award"                                                                                                                                                            
[19401] "Technology_Development_and_Commercialization_Branch"                                                                                                                  
[19402] "Percent_Free_Prostate-Specific_Antigen"                                                                                                                               
[19403] "Transition_Zone_PSA_Density"                                                                                                                                          
[19404] "Pathologic_Ab-Ig_Protein"                                                                                                                                             
[19405] "Immunoglobulin_Gene_Rearrangement"                                                                                                                                    
[19406] "Red_Meat_Consumption"                                                                                                                                                 
[19407] "Diagnostic_or_Prognostic_Factor"                                                                                                                                      
[19408] "High_Vegetable_Diet"                                                                                                                                                  
[19409] "Other_Radiation"                                                                                                                                                      
[19410] "Pharmacogenomics"                                                                                                                                                     
[19411] "Surgically-Created_Resection_Cavity"                                                                                                                                  
[19412] "Papillomavirus_Protein-E4"                                                                                                                                            
[19413] "Papillomavirus_Protein-E2"                                                                                                                                            
[19414] "Academic_Detailing"                                                                                                                                                   
[19415] "Nucleic_Acid_Amplification_Tests"                                                                                                                                     
[19416] "Adenovirus_Protein"                                                                                                                                                   
[19417] "Cancer_Intervention_and_Surveillance_Modeling_Network"                                                                                                                
[19418] "H19_Gene"                                                                                                                                                             
[19419] "Light-Scattering_Spectroscopy"                                                                                                                                        
[19420] "CDKN1B_Gene"                                                                                                                                                          
[19421] "Neuregulin_Receptor"                                                                                                                                                  
[19422] "Cellular_Compartment_Analysis"                                                                                                                                        
[19423] "Combinatorial_Synthesis_of_Small_Molecules"                                                                                                                           
[19424] "Conformation_Dependent_Mutation_Detection"                                                                                                                            
[19425] "Microdeposition"                                                                                                                                                      
[19426] "Microfabrication"                                                                                                                                                     
[19427] "Modeling_of_Cellular_Pathways"                                                                                                                                        
[19428] "Spectral_Karyotyping"                                                                                                                                                 
[19429] "Prognostic_Marker"                                                                                                                                                    
[19430] "WRN_Gene"                                                                                                                                                             
[19431] "Administrative_Supplement"                                                                                                                                            
[19432] "Immunophenotype"                                                                                                                                                      
[19433] "Shiga_Toxin_Beta_Subunit"                                                                                                                                             
[19434] "Telomerase-Associated_Protein-1"                                                                                                                                      
[19435] "Alkyltransferase_and_Aryltransferase"                                                                                                                                 
[19436] "RNA_Polymerase"                                                                                                                                                       
[19437] "v-sis_PDGF_Beta_Polypeptide"                                                                                                                                          
[19438] "SF-36"                                                                                                                                                                
[19439] "SF-12"                                                                                                                                                                
[19440] "Angiography"                                                                                                                                                          
[19441] "Emerging_Technologies"                                                                                                                                                
[19442] "Shared_Pathology_Informatics_Network"                                                                                                                                 
[19443] "Office_of_Communications"                                                                                                                                             
[19444] "Special_Exceptions_Process"                                                                                                                                           
[19445] "Proteomics"                                                                                                                                                           
[19446] "Cancer_Clinical_Trials_Education_Program"                                                                                                                             
[19447] "CancerNet"                                                                                                                                                            
[19448] "CancerTrials"                                                                                                                                                         
[19449] "Minority_Clinical_Oncology_Awards"                                                                                                                                    
[19450] "Cancer_Trials_Support_Unit"                                                                                                                                           
[19451] "Physician_Survey_on_Cancer_Susceptibility_Testing"                                                                                                                    
[19452] "Genome_Scan"                                                                                                                                                          
[19453] "Health_Information_National_Trends_Survey"                                                                                                                            
[19454] "Low-Dose_Spiral_CT"                                                                                                                                                   
[19455] "Co-Receptor_Switch"                                                                                                                                                   
[19456] "Aptamer_Technology"                                                                                                                                                   
[19457] "Virtual_Endoscopy"                                                                                                                                                    
[19458] "DNA_Image_Cytometry"                                                                                                                                                  
[19459] "WNT7A_Gene"                                                                                                                                                           
[19460] "WNT_Family_Gene"                                                                                                                                                      
[19461] "Proto-Oncogene_Signaling_Factor"                                                                                                                                      
[19462] "Hypermethylation"                                                                                                                                                     
[19463] "Receptor_Gene"                                                                                                                                                        
[19464] "Bouvet_Island"                                                                                                                                                        
[19465] "French_Southern_Territories"                                                                                                                                          
[19466] "Heard_Island_and_McDonald_Islands"                                                                                                                                    
[19467] "Kazakhstan"                                                                                                                                                           
[19468] "Country_Code"                                                                                                                                                         
[19469] "Topoisomerase-III_Alpha"                                                                                                                                              
[19470] "Palestinian_Territory_Occupied"                                                                                                                                       
[19471] "South_Georgia_and_the_South_Sandwich_Islands"                                                                                                                         
[19472] "United_States_Minor_Outlying_Islands"                                                                                                                                 
[19473] "Western_Sahara"                                                                                                                                                       
[19474] "Binet_Staging_System"                                                                                                                                                 
[19475] "Rai_Staging_System"                                                                                                                                                   
[19476] "Breast_Cancer_Risk_Factor"                                                                                                                                            
[19477] "Diffusion_MRI"                                                                                                                                                        
[19478] "International_Prognostic_Index"                                                                                                                                       
[19479] "PSA_Velocity"                                                                                                                                                         
[19480] "Age-adjusted_PSA"                                                                                                                                                     
[19481] "Molecular_Carcinogenesis"                                                                                                                                             
[19482] "Experimental_Tobacco_Carcinogenesis"                                                                                                                                  
[19483] "CSK_Gene"                                                                                                                                                             
[19484] "Reticulon-4"                                                                                                                                                          
[19485] "Tankyrase"                                                                                                                                                            
[19486] "Structural_Genomics"                                                                                                                                                  
[19487] "CEA_Assay"                                                                                                                                                            
[19488] "UGT1A1_Gene"                                                                                                                                                          
[19489] "Repairosome"                                                                                                                                                          
[19490] "Protein_Family"                                                                                                                                                       
[19491] "National_Institute_of_General_Medical_Sciences"                                                                                                                       
[19492] "Phosphoprotein_Phosphatase"                                                                                                                                           
[19493] "Anguilla"                                                                                                                                                             
[19494] "Smoking_Behavior"                                                                                                                                                     
[19495] "IGF1R_Gene"                                                                                                                                                           
[19496] "Estrogen_Metabolism"                                                                                                                                                  
[19497] "Nitrosamine_Metabolism"                                                                                                                                               
[19498] "Skeletal_Development"                                                                                                                                                 
[19499] "Ligand_Binding"                                                                                                                                                       
[19500] "Regulation_of_Proteolysis"                                                                                                                                            
[19501] "Soluble_Guanylate_Cyclase"                                                                                                                                            
[19502] "Golgi_Targeting"                                                                                                                                                      
[19503] "Nuclear_Division"                                                                                                                                                     
[19504] "DNA_Replication_Factor"                                                                                                                                               
[19505] "Caspase-2"                                                                                                                                                            
[19506] "Mitotic_Recombination"                                                                                                                                                
[19507] "Transcription_Initiation"                                                                                                                                             
[19508] "Peptide_Metabolism"                                                                                                                                                   
[19509] "Subcellular_Protein_Targeting"                                                                                                                                        
[19510] "Induction_of_Apoptosis"                                                                                                                                               
[19511] "Inflammatory_Response"                                                                                                                                                
[19512] "Telomere_Maintenance"                                                                                                                                                 
[19513] "RNA_Interference"                                                                                                                                                     
[19514] "ACF_Complex"                                                                                                                                                          
[19515] "AREG_Gene"                                                                                                                                                            
[19516] "Radiation-Induced_Recombination"                                                                                                                                      
[19517] "Non-Human_Gene"                                                                                                                                                       
[19518] "Non-Human_Protein"                                                                                                                                                    
[19519] "Drosophila_Protein"                                                                                                                                                   
[19520] "NCI_Center_for_Cancer_Research"                                                                                                                                       
[19521] "Component_of_the_National_Cancer_Institute"                                                                                                                           
[19522] "Component_of_the_Division_of_Cancer_Biology"                                                                                                                          
[19523] "Component_of_the_Division_of_Cancer_Epidemiology_and_Genetics"                                                                                                        
[19524] "Component_of_the_Division_of_Cancer_Prevention"                                                                                                                       
[19525] "Component_of_the_Division_of_Cancer_Treatment_and_Diagnosis"                                                                                                          
[19526] "Component_of_the_Division_of_Extramural_Activities"                                                                                                                   
[19527] "Component_of_the_Intramural_Research_Program"                                                                                                                         
[19528] "Component_of_NCI_Governance"                                                                                                                                          
[19529] "Component_of_the_Office_of_the_Director"                                                                                                                              
[19530] "Component_of_the_Division_of_Cancer_Control_and_Population_Sciences"                                                                                                  
[19531] "Component_of_the_Center_for_Cancer_Research"                                                                                                                          
[19532] "Component_of_the_National_Institutes_of_Health"                                                                                                                       
[19533] "Tetracycline_Control"                                                                                                                                                 
[19534] "NRG1_Gene"                                                                                                                                                            
[19535] "Myelography"                                                                                                                                                          
[19536] "Nephrotomography"                                                                                                                                                     
[19537] "Intravenous_Pyelography"                                                                                                                                              
[19538] "Mammogram"                                                                                                                                                            
[19539] "Toxicogenomics"                                                                                                                                                       
[19540] "Cell_Cycle_Stage"                                                                                                                                                     
[19541] "Conceptual_Entities"                                                                                                                                                  
[19542] "Population_Process"                                                                                                                                                   
[19543] "Telomerase_Reverse_Transcriptase_Protein"                                                                                                                             
[19544] "Protein_Complex_Subunit"                                                                                                                                              
[19545] "Gene_Transfer"                                                                                                                                                        
[19546] "NF-I"                                                                                                                                                                 
[19547] "Cancer_Science"                                                                                                                                                       
[19548] "Social_Concepts"                                                                                                                                                      
[19549] "Properties_or_Attributes"                                                                                                                                             
[19550] "Chemical_Agents"                                                                                                                                                      
[19551] "Cell-Matrix_Adhesion"                                                                                                                                                 
[19552] "Miscellaneous_Occupations"                                                                                                                                            
[19553] "Genetic_Drift"                                                                                                                                                        
[19554] "Regulatory_Gene"                                                                                                                                                      
[19555] "Gene_Fusion"                                                                                                                                                          
[19556] "Cancer_Center"                                                                                                                                                        
[19557] "Male"                                                                                                                                                                 
[19558] "Low_Literacy_Population"                                                                                                                                              
[19559] "Unspecified_Risk_Factor"                                                                                                                                              
[19560] "Outcome"                                                                                                                                                              
[19561] "Lifestyle_Factors_Unspecified"                                                                                                                                        
[19562] "Wireless_Technology"                                                                                                                                                  
[19563] "Laser-Induced_Fluorescence_Endoscopy"                                                                                                                                 
[19564] "Preneoplastic_Change"                                                                                                                                                 
[19565] "Marker_of_Preneoplastic_Change"                                                                                                                                       
[19566] "Sentinel_Lymph_Node_Mapping"                                                                                                                                          
[19567] "Nonhomologous_DNA_End_Joining"                                                                                                                                        
[19568] "TEP1_Gene"                                                                                                                                                            
[19569] "Tumor-Associated_Calcium_Signal_Transducer-1"                                                                                                                         
[19570] "MLH3_Gene"                                                                                                                                                            
[19571] "MSH3_Gene"                                                                                                                                                            
[19572] "Base_Excision_Repair"                                                                                                                                                 
[19573] "Nucleotide_Excision_Repair"                                                                                                                                           
[19574] "Hypoxia-Inducible_Factor-1_Alpha_Subunit"                                                                                                                             
[19575] "Secondary_Cell_Culture"                                                                                                                                               
[19576] "Adherent_Culture"                                                                                                                                                     
[19577] "Suspension_Culture"                                                                                                                                                   
[19578] "Human_Cell_Line"                                                                                                                                                      
[19579] "Monkey_Cell_Line"                                                                                                                                                     
[19580] "Mouse_Cell_Line"                                                                                                                                                      
[19581] "Hamster_Cell_Line"                                                                                                                                                    
[19582] "Rat_Cell_Line"                                                                                                                                                        
[19583] "hGH_Gene"                                                                                                                                                             
[19584] "TK_Gene"                                                                                                                                                              
[19585] "DNA_Interstrand_Cross-Link_Repair"                                                                                                                                    
[19586] "HeLa"                                                                                                                                                                 
[19587] "HeLa_S3"                                                                                                                                                              
[19588] "HeLa_SF"                                                                                                                                                              
[19589] "HL-60_MX2"                                                                                                                                                            
[19590] "HL-60_MX1"                                                                                                                                                            
[19591] "EG_Cell_Line"                                                                                                                                                         
[19592] "ES_Cell_Line"                                                                                                                                                         
[19593] "BG01"                                                                                                                                                                 
[19594] "BG02"                                                                                                                                                                 
[19595] "BG03"                                                                                                                                                                 
[19596] "BG04"                                                                                                                                                                 
[19597] "CY12"                                                                                                                                                                 
[19598] "CY30"                                                                                                                                                                 
[19599] "CY40"                                                                                                                                                                 
[19600] "CY51"                                                                                                                                                                 
[19601] "CY81"                                                                                                                                                                 
[19602] "CY82"                                                                                                                                                                 
[19603] "CY91"                                                                                                                                                                 
[19604] "CY92"                                                                                                                                                                 
[19605] "CY10"                                                                                                                                                                 
[19606] "CyThera_ES_Cell_Line"                                                                                                                                                 
[19607] "BresaGen_ES_Cell_Line"                                                                                                                                                
[19608] "ES_ES_Cell_Line"                                                                                                                                                      
[19609] "ES01"                                                                                                                                                                 
[19610] "ES02"                                                                                                                                                                 
[19611] "ES03"                                                                                                                                                                 
[19612] "ES04"                                                                                                                                                                 
[19613] "ES05"                                                                                                                                                                 
[19614] "ES06"                                                                                                                                                                 
[19615] "Geron_ES_Cell_Line"                                                                                                                                                   
[19616] "GE01"                                                                                                                                                                 
[19617] "GE07"                                                                                                                                                                 
[19618] "GE09"                                                                                                                                                                 
[19619] "GE13"                                                                                                                                                                 
[19620] "GE14"                                                                                                                                                                 
[19621] "GE91"                                                                                                                                                                 
[19622] "GE92"                                                                                                                                                                 
[19623] "Goteborg_ES_Cell_Line"                                                                                                                                                
[19624] "SA01"                                                                                                                                                                 
[19625] "SA02"                                                                                                                                                                 
[19626] "SA03"                                                                                                                                                                 
[19627] "Karolinska_ES_Cell_Line"                                                                                                                                              
[19628] "KA08"                                                                                                                                                                 
[19629] "KA09"                                                                                                                                                                 
[19630] "KA40"                                                                                                                                                                 
[19631] "KA41"                                                                                                                                                                 
[19632] "KA42"                                                                                                                                                                 
[19633] "KA43"                                                                                                                                                                 
[19634] "Maria_ES_Cell_Line"                                                                                                                                                   
[19635] "MB01"                                                                                                                                                                 
[19636] "MB02"                                                                                                                                                                 
[19637] "MB03"                                                                                                                                                                 
[19638] "MizMedi_ES_Cell_Line"                                                                                                                                                 
[19639] "MI01"                                                                                                                                                                 
[19640] "Tara_ES_Cell_Line"                                                                                                                                                    
[19641] "NC01"                                                                                                                                                                 
[19642] "NC02"                                                                                                                                                                 
[19643] "NC03"                                                                                                                                                                 
[19644] "Pochon_ES_Cell_Line"                                                                                                                                                  
[19645] "CH01"                                                                                                                                                                 
[19646] "CH02"                                                                                                                                                                 
[19647] "Reliance_ES_Cell_Line"                                                                                                                                                
[19648] "RL05"                                                                                                                                                                 
[19649] "RL07"                                                                                                                                                                 
[19650] "RL10"                                                                                                                                                                 
[19651] "RL13"                                                                                                                                                                 
[19652] "RL15"                                                                                                                                                                 
[19653] "RL20"                                                                                                                                                                 
[19654] "RL21"                                                                                                                                                                 
[19655] "Technion_ES_Cell_Line"                                                                                                                                                
[19656] "TE03"                                                                                                                                                                 
[19657] "TE32"                                                                                                                                                                 
[19658] "TE33"                                                                                                                                                                 
[19659] "TE04"                                                                                                                                                                 
[19660] "TE06"                                                                                                                                                                 
[19661] "TE62"                                                                                                                                                                 
[19662] "TE07"                                                                                                                                                                 
[19663] "TE72"                                                                                                                                                                 
[19664] "UCSF_ES_Cell_Line"                                                                                                                                                    
[19665] "UC01"                                                                                                                                                                 
[19666] "UC06"                                                                                                                                                                 
[19667] "Wisconsin_ES_Cell_Line"                                                                                                                                               
[19668] "WA01"                                                                                                                                                                 
[19669] "WA07"                                                                                                                                                                 
[19670] "WA09"                                                                                                                                                                 
[19671] "WA13"                                                                                                                                                                 
[19672] "WA14"                                                                                                                                                                 
[19673] "Tumor_Cell_Line"                                                                                                                                                      
[19674] "Protein_Truncation"                                                                                                                                                   
[19675] "Trace_Metal_Storage_Protein"                                                                                                                                          
[19676] "WRN_Protein"                                                                                                                                                          
[19677] "Consumer_Advocates_in_Research_and_Related_Activities"                                                                                                                
[19678] "RecQL4"                                                                                                                                                               
[19679] "Licensing_Factor"                                                                                                                                                     
[19680] "Replication_Initiation_Point_Mapping"                                                                                                                                 
[19681] "hCdt1"                                                                                                                                                                
[19682] "HMGA1a"                                                                                                                                                               
[19683] "HMGA1b"                                                                                                                                                               
[19684] "HMGA2"                                                                                                                                                                
[19685] "HMGA_Family_Protein"                                                                                                                                                  
[19686] "HMGB_Family_Protein"                                                                                                                                                  
[19687] "HMGN_Family_Protein"                                                                                                                                                  
[19688] "HMGB1"                                                                                                                                                                
[19689] "HMGB3"                                                                                                                                                                
[19690] "HMGB2"                                                                                                                                                                
[19691] "HMGA1c"                                                                                                                                                               
[19692] "HMGN3_Protein"                                                                                                                                                        
[19693] "HMGN4"                                                                                                                                                                
[19694] "XRCC2_Gene"                                                                                                                                                           
[19695] "XRCC3_Gene"                                                                                                                                                           
[19696] "Telomere_Length_Maintenance"                                                                                                                                          
[19697] "PRKDC_Gene"                                                                                                                                                           
[19698] "Telomere_Maintenance_Gene"                                                                                                                                            
[19699] "Telomere_Capping"                                                                                                                                                     
[19700] "Telomere_Recombination"                                                                                                                                               
[19701] "Elongation_by_Telomerase"                                                                                                                                             
[19702] "Internet"                                                                                                                                                             
[19703] "Human_Glandular_Kallikrein"                                                                                                                                           
[19704] "OGG1_Gene"                                                                                                                                                            
[19705] "EXO1_Gene"                                                                                                                                                            
[19706] "Atomic_Resolution_Microscopy"                                                                                                                                         
[19707] "Apoptosis_Inhibitor_Gene"                                                                                                                                             
[19708] "Apoptosis_Promoter_Gene"                                                                                                                                              
[19709] "M-Phase"                                                                                                                                                              
[19710] "BIRC5_Gene"                                                                                                                                                           
[19711] "MAGE_Family_A_Gene"                                                                                                                                                   
[19712] "BIRC6_Gene"                                                                                                                                                           
[19713] "BIRC7_Gene"                                                                                                                                                           
[19714] "BIRC1_Gene"                                                                                                                                                           
[19715] "BIRC2_Gene"                                                                                                                                                           
[19716] "BIRC3_Gene"                                                                                                                                                           
[19717] "BIRC4_Gene"                                                                                                                                                           
[19718] "APAF1_Gene"                                                                                                                                                           
[19719] "TOPBP1_Gene"                                                                                                                                                          
[19720] "FLJ20174_Gene"                                                                                                                                                        
[19721] "XPA_Gene"                                                                                                                                                             
[19722] "XRCC4_Gene"                                                                                                                                                           
[19723] "XRCC5_Gene"                                                                                                                                                           
[19724] "Small_Inducible_Cytokine-C1"                                                                                                                                          
[19725] "Replication_Licensing"                                                                                                                                                
[19726] "Diaphranography"                                                                                                                                                      
[19727] "MCM_Protein"                                                                                                                                                          
[19728] "Research_Techniques"                                                                                                                                                  
[19729] "Microtechniques"                                                                                                                                                      
[19730] "Replication_Initiation_Gene"                                                                                                                                          
[19731] "ORC_Subunit_Gene"                                                                                                                                                     
[19732] "Licensing_Factor_Gene"                                                                                                                                                
[19733] "MCM2_Gene"                                                                                                                                                            
[19734] "MCM4_Gene"                                                                                                                                                            
[19735] "MCM5_Gene"                                                                                                                                                            
[19736] "MCM6_Gene"                                                                                                                                                            
[19737] "MCM3_Gene"                                                                                                                                                            
[19738] "MCM7_Gene"                                                                                                                                                            
[19739] "CDC45L_Gene"                                                                                                                                                          
[19740] "ORC2L_Gene"                                                                                                                                                           
[19741] "CDT1_Gene"                                                                                                                                                            
[19742] "CDC6_Gene"                                                                                                                                                            
[19743] "MCM10_Gene"                                                                                                                                                           
[19744] "CDC7_Gene"                                                                                                                                                            
[19745] "ASK_Gene"                                                                                                                                                             
[19746] "ORC1L_Gene"                                                                                                                                                           
[19747] "ORC4L_Gene"                                                                                                                                                           
[19748] "ORC5L_Gene"                                                                                                                                                           
[19749] "ORC6L_Gene"                                                                                                                                                           
[19750] "ORC3L_Gene"                                                                                                                                                           
[19751] "Neurotrophic_Factor"                                                                                                                                                  
[19752] "Neuropoietic_Cytokine"                                                                                                                                                
[19753] "Heparin-Binding_Neurotrophic_Factor"                                                                                                                                  
[19754] "WNT_Family_Protein"                                                                                                                                                   
[19755] "GMNN_Gene"                                                                                                                                                            
[19756] "Protein_Phosphatase-2A_Subunit_Gene"                                                                                                                                  
[19757] "PR48_Gene"                                                                                                                                                            
[19758] "PPP2CA_Gene"                                                                                                                                                          
[19759] "PPP2CB_Gene"                                                                                                                                                          
[19760] "Monoclonal_Antibody"                                                                                                                                                  
[19761] "PPP2R5A_Gene"                                                                                                                                                         
[19762] "PPP2R5B_Gene"                                                                                                                                                         
[19763] "PPP2R5C_Gene"                                                                                                                                                         
[19764] "PPP2R5D_Gene"                                                                                                                                                         
[19765] "PPP2R5E_Gene"                                                                                                                                                         
[19766] "PPP2R4_Gene"                                                                                                                                                          
[19767] "VAV_Family_Gene"                                                                                                                                                      
[19768] "BCL-2_Gene_Family"                                                                                                                                                    
[19769] "BCL2L1_Gene"                                                                                                                                                          
[19770] "BCL2L2_Gene"                                                                                                                                                          
[19771] "MCL1_Gene"                                                                                                                                                            
[19772] "BAK1_Gene"                                                                                                                                                            
[19773] "BAD_Gene"                                                                                                                                                             
[19774] "BCL-Xs_Protein"                                                                                                                                                       
[19775] "BCL2L11_Gene"                                                                                                                                                         
[19776] "BIK_Gene"                                                                                                                                                             
[19777] "HRK_Gene"                                                                                                                                                             
[19778] "BID_Gene"                                                                                                                                                             
[19779] "Transcription_Factor_Gene"                                                                                                                                            
[19780] "TAF1_Gene"                                                                                                                                                            
[19781] "Mitochondrial_Membrane_Protein"                                                                                                                                       
[19782] "Helicase"                                                                                                                                                             
[19783] "Growth_Factor"                                                                                                                                                        
[19784] "Epidermal_Growth_Factor"                                                                                                                                              
[19785] "Fibroblast_Growth_Factor"                                                                                                                                             
[19786] "Hematopoietic_Growth_Factor"                                                                                                                                          
[19787] "Hepatocyte_Growth_Factor"                                                                                                                                             
[19788] "Erythropoietin"                                                                                                                                                       
[19789] "Angiogenin"                                                                                                                                                           
[19790] "Amphiregulin"                                                                                                                                                         
[19791] "Betacellulin"                                                                                                                                                         
[19792] "Neuregulin"                                                                                                                                                           
[19793] "Fibroblast_Growth_Factor-5"                                                                                                                                           
[19794] "Fibroblast_Growth_Factor-6"                                                                                                                                           
[19795] "Fibroblast_Growth_Factor-7"                                                                                                                                           
[19796] "Colony_Stimulating_Factor-1"                                                                                                                                          
[19797] "Granulocyte_Colony-Stimulating_Factor"                                                                                                                                
[19798] "Interleukin-3"                                                                                                                                                        
[19799] "Kit_Ligand"                                                                                                                                                           
[19800] "Thrombopoietin"                                                                                                                                                       
[19801] "Insulin-Like_Growth_Factor"                                                                                                                                           
[19802] "Neurotrophin"                                                                                                                                                         
[19803] "Nerve_Growth_Factor"                                                                                                                                                  
[19804] "Brain-Derived_Neurotrophic_Factor"                                                                                                                                    
[19805] "Glial_Cell_Line_Derived_Neurotrophic_Factor"                                                                                                                          
[19806] "Parathyroid_Hormone-Like_Hormone"                                                                                                                                     
[19807] "Platelet-Derived_Growth_Factor"                                                                                                                                       
[19808] "Platelet_Derived_Growth_Factor_Beta_Chain"                                                                                                                            
[19809] "Vascular_Endothelial_Growth_Factor"                                                                                                                                   
[19810] "Interleukin-6"                                                                                                                                                        
[19811] "Pleiotrophin"                                                                                                                                                         
[19812] "Transforming_Growth_Factor"                                                                                                                                           
[19813] "Transforming_Growth_Factor_Alpha"                                                                                                                                     
[19814] "Transforming_Growth_Factor-Beta"                                                                                                                                      
[19815] "Activin"                                                                                                                                                              
[19816] "Transforming_Growth_Factor_Beta-1"                                                                                                                                    
[19817] "Transforming_Growth_Factor_Beta-2"                                                                                                                                    
[19818] "Transforming_Growth_Factor_Beta-3"                                                                                                                                    
[19819] "TBP_Gene"                                                                                                                                                             
[19820] "World_Wide_Web"                                                                                                                                                       
[19821] "Apoptosis_Regulation_Gene"                                                                                                                                            
[19822] "TERC_Gene"                                                                                                                                                            
[19823] "Cytokine"                                                                                                                                                             
[19824] "ATL_Derived_Factor"                                                                                                                                                   
[19825] "Chemokine"                                                                                                                                                            
[19826] "Alpha_Chemokine"                                                                                                                                                      
[19827] "Beta_Thromboglobulin"                                                                                                                                                 
[19828] "Connective-Tissue-Activating_Peptide-III"                                                                                                                             
[19829] "Epithelial_Neutrophil_Activating_Peptide-78"                                                                                                                          
[19830] "C-X-C_Motif_Chemokine_Ligand-1"                                                                                                                                       
[19831] "Interferon-alpha_Inducible_Protein_10"                                                                                                                                
[19832] "Interleukin-8"                                                                                                                                                        
[19833] "Macrophage_Inflammatory_Protein-2_Alpha"                                                                                                                              
[19834] "Macrophage_Inflammatory_Protein-2_Beta"                                                                                                                               
[19835] "Beta_Chemokine"                                                                                                                                                       
[19836] "C-C_Motif_Chemokine_Ligand-4"                                                                                                                                         
[19837] "Small_Inducible_Cytokine-A1"                                                                                                                                          
[19838] "Small_Inducible_Cytokine-A8"                                                                                                                                          
[19839] "Cellular_Process"                                                                                                                                                     
[19840] "Small_Inducible_Cytokine-A3"                                                                                                                                          
[19841] "Monocyte_Chemoattractant_Protein-1"                                                                                                                                   
[19842] "Small_Inducible_Cytokine-A5"                                                                                                                                          
[19843] "Small_Inducible_Cytokine-A21"                                                                                                                                         
[19844] "Small_Inducible_Cytokine-A11"                                                                                                                                         
[19845] "Unclassified_Chemokine"                                                                                                                                               
[19846] "C5a"                                                                                                                                                                  
[19847] "Delta_Chemokine"                                                                                                                                                      
[19848] "Small_Inducible_Cytokine-D1"                                                                                                                                          
[19849] "Gamma_Chemokine"                                                                                                                                                      
[19850] "Molecular_Nanotechnology"                                                                                                                                             
[19851] "FLT3_Ligand"                                                                                                                                                          
[19852] "Interferon"                                                                                                                                                           
[19853] "Interferon_Alpha"                                                                                                                                                     
[19854] "Interferon_Beta"                                                                                                                                                      
[19855] "Interferon_Gamma"                                                                                                                                                     
[19856] "Interleukin"                                                                                                                                                          
[19857] "Lymphokine"                                                                                                                                                           
[19858] "Oncostatin-M"                                                                                                                                                         
[19859] "Tumor_Necrosis_Factor_Family_Protein"                                                                                                                                 
[19860] "TAF2_Gene"                                                                                                                                                            
[19861] "TAF3_Gene"                                                                                                                                                            
[19862] "TAF4_Gene"                                                                                                                                                            
[19863] "Cell_Maintenance"                                                                                                                                                     
[19864] "TAF5_Gene"                                                                                                                                                            
[19865] "Interleukin-1"                                                                                                                                                        
[19866] "Interleukin-2"                                                                                                                                                        
[19867] "Interleukin-4"                                                                                                                                                        
[19868] "Interleukin-5"                                                                                                                                                        
[19869] "Interleukin-7"                                                                                                                                                        
[19870] "Interleukin-9"                                                                                                                                                        
[19871] "Interleukin-10"                                                                                                                                                       
[19872] "Interleukin-11"                                                                                                                                                       
[19873] "Interleukin-12"                                                                                                                                                       
[19874] "Interleukin-13"                                                                                                                                                       
[19875] "Interleukin-14"                                                                                                                                                       
[19876] "Interleukin-15"                                                                                                                                                       
[19877] "Interleukin-16"                                                                                                                                                       
[19878] "Interleukin-17"                                                                                                                                                       
[19879] "Interleukin-18"                                                                                                                                                       
[19880] "Interleukin-1-Alpha"                                                                                                                                                  
[19881] "Interleukin-1-Beta"                                                                                                                                                   
[19882] "Leukocyte_Interleukin"                                                                                                                                                
[19883] "Leukemia_Inhibitory_Factor"                                                                                                                                           
[19884] "Leukoregulin"                                                                                                                                                         
[19885] "TAF6_Gene"                                                                                                                                                            
[19886] "TAF7_Gene"                                                                                                                                                            
[19887] "CD40_Ligand"                                                                                                                                                          
[19888] "FAS_Ligand"                                                                                                                                                           
[19889] "Tumor_Necrosis_Factor-C"                                                                                                                                              
[19890] "TAF7L_Gene"                                                                                                                                                           
[19891] "CD134_Ligand"                                                                                                                                                         
[19892] "TRAIL_Protein"                                                                                                                                                        
[19893] "TAF8_Gene"                                                                                                                                                            
[19894] "Tumor_Necrosis_Factor-Alpha"                                                                                                                                          
[19895] "Tumor_Necrosis_Factor-Beta"                                                                                                                                           
[19896] "TAF9_Gene"                                                                                                                                                            
[19897] "TAF10_Gene"                                                                                                                                                           
[19898] "TBP-Associated_Factor_Gene"                                                                                                                                           
[19899] "TAF11_Gene"                                                                                                                                                           
[19900] "TAF12_Gene"                                                                                                                                                           
[19901] "TAF13_Gene"                                                                                                                                                           
[19902] "TFIID_Subunit_Gene"                                                                                                                                                   
[19903] "TFIIA_Subunit_Gene"                                                                                                                                                   
[19904] "Colony_Stimulating_Factor-2"                                                                                                                                          
[19905] "Sonogram"                                                                                                                                                             
[19906] "Fibroblast_Growth_Factor-2"                                                                                                                                           
[19907] "Fibroblast_Growth_Factor-1"                                                                                                                                           
[19908] "Fibroblast_Growth_Factor-3"                                                                                                                                           
[19909] "Fibroblast_Growth_Factor-4"                                                                                                                                           
[19910] "TBPL1_Gene"                                                                                                                                                           
[19911] "PMS2L1_Gene"                                                                                                                                                          
[19912] "APEXL2_Gene"                                                                                                                                                          
[19913] "ERCC1_Gene"                                                                                                                                                           
[19914] "ERCC2_Gene"                                                                                                                                                           
[19915] "ERCC3_Gene"                                                                                                                                                           
[19916] "ERCC5_Gene"                                                                                                                                                           
[19917] "ERCC4_Gene"                                                                                                                                                           
[19918] "TREX1_Gene"                                                                                                                                                           
[19919] "ATR_Gene"                                                                                                                                                             
[19920] "TREX2_Gene"                                                                                                                                                           
[19921] "TERF2_Gene"                                                                                                                                                           
[19922] "TERF1_Gene"                                                                                                                                                           
[19923] "TINF2_Gene"                                                                                                                                                           
[19924] "LIG4_Gene"                                                                                                                                                            
[19925] "Ku_Subunit_Gene"                                                                                                                                                      
[19926] "XAF1_Gene"                                                                                                                                                            
[19927] "G22P1_Gene"                                                                                                                                                           
[19928] "Shunt"                                                                                                                                                                
[19929] "HMG_Family_Gene"                                                                                                                                                      
[19930] "Canonical_HMG_Gene"                                                                                                                                                   
[19931] "HMG_Motif_Genes"                                                                                                                                                      
[19932] "HMGA_Family_Gene"                                                                                                                                                     
[19933] "HMGB_Family_Gene"                                                                                                                                                     
[19934] "HMGN_Family_Gene"                                                                                                                                                     
[19935] "HMGA1_Gene"                                                                                                                                                           
[19936] "HMGA2_Gene"                                                                                                                                                           
[19937] "HMGB1_Gene"                                                                                                                                                           
[19938] "HMGB2_Gene"                                                                                                                                                           
[19939] "HMGB3_Gene"                                                                                                                                                           
[19940] "HMGN1_Gene"                                                                                                                                                           
[19941] "HMGN2_Gene"                                                                                                                                                           
[19942] "HMGN3_Gene"                                                                                                                                                           
[19943] "HMGN4_Gene"                                                                                                                                                           
[19944] "MAP-Kinase_Kinase_Kinase_8"                                                                                                                                           
[19945] "Colony_Stimulating_Factor"                                                                                                                                            
[19946] "Age_Group"                                                                                                                                                            
[19947] "GAG_Protein"                                                                                                                                                          
[19948] "Gene_Amplification_Technique"                                                                                                                                         
[19949] "Arylesterase"                                                                                                                                                         
[19950] "SWI-SNF_Family_Complex"                                                                                                                                               
[19951] "ISWI_Family_Protein"                                                                                                                                                  
[19952] "TFIIH"                                                                                                                                                                
[19953] "GTF2A1_Gene"                                                                                                                                                          
[19954] "RecQ_Helicase_Family_Protein"                                                                                                                                         
[19955] "RecQ_Protein-Like-5_Protein"                                                                                                                                          
[19956] "ALF_Gene"                                                                                                                                                             
[19957] "GTF2A2_Gene"                                                                                                                                                          
[19958] "TBP_Inhibitor_Gene"                                                                                                                                                   
[19959] "DR1_Gene"                                                                                                                                                             
[19960] "DRAP1_Gene"                                                                                                                                                           
[19961] "B-TFIID_Subunit_Gene"                                                                                                                                                 
[19962] "BTAF1_Gene"                                                                                                                                                           
[19963] "Affinity"                                                                                                                                                             
[19964] "Developmental_Anatomy"                                                                                                                                                
[19965] "Catchment_Area"                                                                                                                                                       
[19966] "Arteriogram"                                                                                                                                                          
[19967] "Radiation_Biophysics"                                                                                                                                                 
[19968] "Synthesis_Chemistry"                                                                                                                                                  
[19969] "Partition_Coefficient"                                                                                                                                                
[19970] "Cytopathology"                                                                                                                                                        
[19971] "Dephosphorylation"                                                                                                                                                    
[19972] "Clonal_Expansion"                                                                                                                                                     
[19973] "Primer_Extension"                                                                                                                                                     
[19974] "Cancer_Family"                                                                                                                                                        
[19975] "Recombination_Fraction"                                                                                                                                               
[19976] "Housekeeping_Gene"                                                                                                                                                    
[19977] "Quantitative_Genetics"                                                                                                                                                
[19978] "Granzyme"                                                                                                                                                             
[19979] "Gustation"                                                                                                                                                            
[19980] "Hematopathology"                                                                                                                                                      
[19981] "Somatic_Cell_Hybridization"                                                                                                                                           
[19982] "Immunobiology"                                                                                                                                                        
[19983] "Embryonic_Induction"                                                                                                                                                  
[19984] "Tumor_Cell_Invasion"                                                                                                                                                  
[19985] "Enzyme_Kinetics"                                                                                                                                                      
[19986] "Linker-Scanning_Mutagenesis"                                                                                                                                          
[19987] "Melanogenesis"                                                                                                                                                        
[19988] "Silent_Mutation"                                                                                                                                                      
[19989] "Neuropathogenesis"                                                                                                                                                    
[19990] "Comparative_Pathology"                                                                                                                                                
[19991] "Pathophysiology"                                                                                                                                                      
[19992] "Biochemical_Pharmacology"                                                                                                                                             
[19993] "Radiation_Physics"                                                                                                                                                    
[19994] "Polymerase"                                                                                                                                                           
[19995] "Sp1_Transcription_Factor"                                                                                                                                             
[19996] "Community_Psychology"                                                                                                                                                 
[19997] "Mismatch_Repair"                                                                                                                                                      
[19998] "Ommaya_Reservoir"                                                                                                                                                     
[19999] "Performance_Status"                                                                                                                                                   
[20000] "Stereotaxis"                                                                                                                                                          
[20001] "Schiller_Test"                                                                                                                                                        
[20002] "High_Resolution_Computed_Tomography"                                                                                                                                  
[20003] "Spiral_CT"                                                                                                                                                            
[20004] "Topoisomerase"                                                                                                                                                        
[20005] "TFIIE_Subunit_Gene"                                                                                                                                                   
[20006] "GTF2B_Gene"                                                                                                                                                           
[20007] "GTF2E1_Gene"                                                                                                                                                          
[20008] "GTF2E2_Gene"                                                                                                                                                          
[20009] "TFIIF_Subunit_Gene"                                                                                                                                                   
[20010] "GTF2F1_Gene"                                                                                                                                                          
[20011] "GTF2F2_Gene"                                                                                                                                                          
[20012] "TFIIH_Subunit_Gene"                                                                                                                                                   
[20013] "TFIIH_Core_Subunit_Gene"                                                                                                                                              
[20014] "GTF2H1_Gene"                                                                                                                                                          
[20015] "XPD_Gene"                                                                                                                                                             
[20016] "Mediator_Complex_Component_Gene"                                                                                                                                      
[20017] "MED6_Gene"                                                                                                                                                            
[20018] "RNA_Polymerase-II_Subunit_Gene"                                                                                                                                       
[20019] "POLR2A_Gene"                                                                                                                                                          
[20020] "Nursing_Informatics"                                                                                                                                                  
[20021] "TFIIIC_Subunit_Gene"                                                                                                                                                  
[20022] "GTF3C3_Gene"                                                                                                                                                          
[20023] "GTF3C1_Gene"                                                                                                                                                          
[20024] "GTF3C2_Gene"                                                                                                                                                          
[20025] "GTF3C4_Gene"                                                                                                                                                          
[20026] "GTF3C5_Gene"                                                                                                                                                          
[20027] "TFIIIB_Subunit_Gene"                                                                                                                                                  
[20028] "BRF1_Gene"                                                                                                                                                            
[20029] "BDP1_Gene"                                                                                                                                                            
[20030] "BRF2_Gene"                                                                                                                                                            
[20031] "Transcription_Coactivator_Gene"                                                                                                                                       
[20032] "X-Chromosome_Inactivation"                                                                                                                                            
[20033] "PC4_Gene"                                                                                                                                                             
[20034] "PSIP1_Gene"                                                                                                                                                           
[20035] "Microscope"                                                                                                                                                           
[20036] "Robot"                                                                                                                                                                
[20037] "Serine-Threonine_Phosphorylation"                                                                                                                                     
[20038] "Electrolaryngeal_Speech"                                                                                                                                              
[20039] "Tracheoesophageal_Speech"                                                                                                                                             
[20040] "PPARBP_Gene"                                                                                                                                                          
[20041] "CRSP2_Gene"                                                                                                                                                           
[20042] "Chromogranin-B"                                                                                                                                                       
[20043] "Secretogranin-II"                                                                                                                                                     
[20044] "Sp1_Activation_Cofactor_Gene"                                                                                                                                         
[20045] "CRSP3_Gene"                                                                                                                                                           
[20046] "CRSP6_Gene"                                                                                                                                                           
[20047] "CRSP7_Gene"                                                                                                                                                           
[20048] "CRSP8_Gene"                                                                                                                                                           
[20049] "CRSP9_Gene"                                                                                                                                                           
[20050] "Nuclear_Receptor_Coactivator_Gene"                                                                                                                                    
[20051] "Cytokeratin"                                                                                                                                                          
[20052] "Intermediate_Filament_Protein"                                                                                                                                        
[20053] "NCOA1_Gene"                                                                                                                                                           
[20054] "Other_Evaluation_of_Risk_Factors"                                                                                                                                     
[20055] "NCOA2_Gene"                                                                                                                                                           
[20056] "Breast_Cancer_Early_Detection"                                                                                                                                        
[20057] "NCOA3_Gene"                                                                                                                                                           
[20058] "NCOA5_Gene"                                                                                                                                                           
[20059] "Alcohol_Abuse"                                                                                                                                                        
[20060] "NCOA6_Gene"                                                                                                                                                           
[20061] "Transcription_Corepressor_Gene"                                                                                                                                       
[20062] "NRIP1_Gene"                                                                                                                                                           
[20063] "MHC_Class-II_Protein"                                                                                                                                                 
[20064] "MHC_Class-I_Protein"                                                                                                                                                  
[20065] "NR0B2_Gene"                                                                                                                                                           
[20066] "Orphan_Nuclear_Receptor_Gene"                                                                                                                                         
[20067] "Nuclear_Receptor_Gene"                                                                                                                                                
[20068] "Transcription_Coregulator_Gene"                                                                                                                                       
[20069] "SP1_Gene"                                                                                                                                                             
[20070] "CRSP4_Gene"                                                                                                                                                           
[20071] "Autoantigen_Gene"                                                                                                                                                     
[20072] "AMPH_Gene"                                                                                                                                                            
[20073] "BARD1_Gene"                                                                                                                                                           
[20074] "Serine_Hydrolase_Gene"                                                                                                                                                
[20075] "BPHL_Gene"                                                                                                                                                            
[20076] "DDR1_Gene"                                                                                                                                                            
[20077] "Receptor_Tyrosine_Kinase_Gene"                                                                                                                                        
[20078] "CDH3_Gene"                                                                                                                                                            
[20079] "Cell_Adhesion_Receptor_Gene"                                                                                                                                          
[20080] "CDH5_Gene"                                                                                                                                                            
[20081] "CDH13_Gene"                                                                                                                                                           
[20082] "CREBL2_Gene"                                                                                                                                                          
[20083] "Cysteine_Proteinase_Inhibitor_Gene"                                                                                                                                   
[20084] "Cystatin_Superfamily_Gene"                                                                                                                                            
[20085] "Cystatin_Family_Gene"                                                                                                                                                 
[20086] "CST6_Gene"                                                                                                                                                            
[20087] "Stefin_Family_Gene"                                                                                                                                                   
[20088] "Kininogen_Family_Gene"                                                                                                                                                
[20089] "Protein_Phosphatase_Gene"                                                                                                                                             
[20090] "DUSP3_Gene"                                                                                                                                                           
[20091] "FABP_Family_Gene"                                                                                                                                                     
[20092] "FABP3_Gene"                                                                                                                                                           
[20093] "RNA_Binding"                                                                                                                                                          
[20094] "Lipid_Binding"                                                                                                                                                        
[20095] "Lipid_Transport"                                                                                                                                                      
[20096] "Histone_Acetylation"                                                                                                                                                  
[20097] "Tumor_Cell_Mobility"                                                                                                                                                  
[20098] "FGFR4_Gene"                                                                                                                                                           
[20099] "Structural_Gene"                                                                                                                                                      
[20100] "Cytoskeletal_Gene"                                                                                                                                                    
[20101] "Microfilament_Gene"                                                                                                                                                   
[20102] "GAS2_Gene"                                                                                                                                                            
[20103] "Regulation_of_Cell_Shape"                                                                                                                                             
[20104] "Segmental_Mastectomy"                                                                                                                                                 
[20105] "Cell_Proliferation_Regulation"                                                                                                                                        
[20106] "Inhibition_of_Cell_Proliferation"                                                                                                                                     
[20107] "GAS8_Gene"                                                                                                                                                            
[20108] "ACRBP_Gene"                                                                                                                                                           
[20109] "AGR2_Gene"                                                                                                                                                            
[20110] "ANP32C_Gene"                                                                                                                                                          
[20111] "HMMR_Gene"                                                                                                                                                            
[20112] "Hyaluronic_Acid_Binding"                                                                                                                                              
[20113] "ANP32D_Gene"                                                                                                                                                          
[20114] "APPBP2_Gene"                                                                                                                                                          
[20115] "ARHI_Gene"                                                                                                                                                            
[20116] "Metastasis_Suppressor_Gene"                                                                                                                                           
[20117] "AXIN2_Gene"                                                                                                                                                           
[20118] "Metastasis_Suppression"                                                                                                                                               
[20119] "KISS1_Gene"                                                                                                                                                           
[20120] "BAP1_Gene"                                                                                                                                                            
[20121] "BCAR1_Gene"                                                                                                                                                           
[20122] "Cytoskeletal_Modeling"                                                                                                                                                
[20123] "BCAR2_Gene"                                                                                                                                                           
[20124] "BCAR3_Gene"                                                                                                                                                           
[20125] "BCAS1_Gene"                                                                                                                                                           
[20126] "BCAS2_Gene"                                                                                                                                                           
[20127] "BCAS3_Gene"                                                                                                                                                           
[20128] "BCAS4_Gene"                                                                                                                                                           
[20129] "BRCD1_Gene"                                                                                                                                                           
[20130] "BCPR_Gene"                                                                                                                                                            
[20131] "BC-2_Gene"                                                                                                                                                            
[20132] "BRCA3_Gene"                                                                                                                                                           
[20133] "NY-BR-1_Gene"                                                                                                                                                         
[20134] "BRMS1_Gene"                                                                                                                                                           
[20135] "COX7A2L_Gene"                                                                                                                                                         
[20136] "DLC1_Gene"                                                                                                                                                            
[20137] "Epithelial_Protein_Up-Regulated_in_Carcinoma_Membrane_Associated_Protein_17_Gene"                                                                                     
[20138] "EPSTI1_Gene"                                                                                                                                                          
[20139] "FBXW7_Gene"                                                                                                                                                           
[20140] "GA_Gene"                                                                                                                                                              
[20141] "GAGED3_Gene"                                                                                                                                                          
[20142] "CLCA2_Gene"                                                                                                                                                           
[20143] "HYOU1_Gene"                                                                                                                                                           
[20144] "ADAM_Family_Gene"                                                                                                                                                     
[20145] "ADAM11_Gene"                                                                                                                                                          
[20146] "IL24_Gene"                                                                                                                                                            
[20147] "MLN51_Gene"                                                                                                                                                           
[20148] "NY-BR-20_Gene"                                                                                                                                                        
[20149] "NY-BR-84_Gene"                                                                                                                                                        
[20150] "C6orf49_Gene"                                                                                                                                                         
[20151] "PHEMX_Gene"                                                                                                                                                           
[20152] "BCAA_Gene"                                                                                                                                                            
[20153] "LOC118430_Gene"                                                                                                                                                       
[20154] "TACC2_Gene"                                                                                                                                                           
[20155] "TRAF4_Gene"                                                                                                                                                           
[20156] "TSSC4_Gene"                                                                                                                                                           
[20157] "MSMB_Gene"                                                                                                                                                            
[20158] "BLM_Gene"                                                                                                                                                             
[20159] "WFDC1_Gene"                                                                                                                                                           
[20160] "WNT4_Gene"                                                                                                                                                            
[20161] "ABCG2_Gene"                                                                                                                                                           
[20162] "RAD54L_Gene"                                                                                                                                                          
[20163] "Platelet_Basic_Protein"                                                                                                                                               
[20164] "Platelet_Factor-4"                                                                                                                                                    
[20165] "Coagulation"                                                                                                                                                          
[20166] "RAD51_Family_Gene"                                                                                                                                                    
[20167] "RAD51C_Gene"                                                                                                                                                          
[20168] "NOVA1_Gene"                                                                                                                                                           
[20169] "TXN_Gene"                                                                                                                                                             
[20170] "Paraneoplastic_Disease_Antigen_Gene"                                                                                                                                  
[20171] "NOVA_Family_Gene"                                                                                                                                                     
[20172] "Nucleoporin_Gene"                                                                                                                                                     
[20173] "NUP98_Gene"                                                                                                                                                           
[20174] "Nurse"                                                                                                                                                                
[20175] "Licensed_Practical_Nurse"                                                                                                                                             
[20176] "Strategic_Supplement_Program"                                                                                                                                         
[20177] "Registered_Nurse"                                                                                                                                                     
[20178] "Advanced_Practice_Nurse"                                                                                                                                              
[20179] "Molecular_Diagnosis"                                                                                                                                                  
[20180] "Optical_Biopsy"                                                                                                                                                       
[20181] "Optical_Coherence_Tomography"                                                                                                                                         
[20182] "SLC22A1L_Gene"                                                                                                                                                        
[20183] "Certified_Nurse_Midwife"                                                                                                                                              
[20184] "Certified_Registered_Nurse_Anesthetist"                                                                                                                               
[20185] "Clinical_Nurse_Specialist"                                                                                                                                            
[20186] "Cardiovascular_Nurse"                                                                                                                                                 
[20187] "Community_Health_Nurse_Specialist"                                                                                                                                    
[20188] "Diabetes_Management_Nurse_Specialist"                                                                                                                                 
[20189] "Enterostomal_Therapy_Nurse_Specialist"                                                                                                                                
[20190] "Gerontological_Nurse_Specialist"                                                                                                                                      
[20191] "Home_Health_Nurse_Specialist"                                                                                                                                         
[20192] "PHB_Gene"                                                                                                                                                             
[20193] "Medical-Surgical_Nurse_Specialist"                                                                                                                                    
[20194] "Nurse_Psychotherapist"                                                                                                                                                
[20195] "Oncology_Nurse_Specialist"                                                                                                                                            
[20196] "Pediatric_Nurse_Specialist"                                                                                                                                           
[20197] "Nurse_Educator"                                                                                                                                                       
[20198] "Ribosome_Subunit_Gene"                                                                                                                                                
[20199] "RPL13_Gene"                                                                                                                                                           
[20200] "Ribonucleotide_Reductase_Subunit_Gene"                                                                                                                                
[20201] "RRM1_Gene"                                                                                                                                                            
[20202] "S100_Family_Gene"                                                                                                                                                     
[20203] "S100A2_Gene"                                                                                                                                                          
[20204] "Centers_of_Excellence_in_Cancer_Communications_Research"                                                                                                              
[20205] "Nurse_Practitioner"                                                                                                                                                   
[20206] "Case_Management_Nurse"                                                                                                                                                
[20207] "Non-Clinical_Specialty_Nurse"                                                                                                                                         
[20208] "Informatics_Nurse_Specialist"                                                                                                                                         
[20209] "Neurodegenerative_Disease_Gene"                                                                                                                                       
[20210] "Synuclein_Family_Gene"                                                                                                                                                
[20211] "SNCG_Gene"                                                                                                                                                            
[20212] "Nurse_Administrator"                                                                                                                                                  
[20213] "Nurse_Specialist_in_Health_and_Public_Policy"                                                                                                                         
[20214] "Unlicensed_Assistive_Personnel"                                                                                                                                       
[20215] "STIM1_Gene"                                                                                                                                                           
[20216] "Stimulation_of_Cell_Proliferation"                                                                                                                                    
[20217] "TACC1_Gene"                                                                                                                                                           
[20218] "Information_and_Media"                                                                                                                                                
[20219] "Ambulatory_Care_Nursing"                                                                                                                                              
[20220] "Cardiac_Vascular_Nursing"                                                                                                                                             
[20221] "Clinical_Nursing"                                                                                                                                                     
[20222] "Hospital_Nursing"                                                                                                                                                     
[20223] "Long-Term_Care_Nursing"                                                                                                                                               
[20224] "Trefoil_Family_Gene"                                                                                                                                                  
[20225] "TFF1_Gene"                                                                                                                                                            
[20226] "GPR39_Gene"                                                                                                                                                           
[20227] "Medical-Surgical_Nursing"                                                                                                                                             
[20228] "Orthopedic_Nursing"                                                                                                                                                   
[20229] "Subacute_Nursing"                                                                                                                                                     
[20230] "Clinical_Research_Nursing"                                                                                                                                            
[20231] "Flight_Nursing"                                                                                                                                                       
[20232] "OR_Nursing"                                                                                                                                                           
[20233] "Perianesthesia_Nursing"                                                                                                                                               
[20234] "Emergency_Room_Nursing"                                                                                                                                               
[20235] "Trauma_Nursing"                                                                                                                                                       
[20236] "Home_Health_Nursing"                                                                                                                                                  
[20237] "Infusion_Nursing"                                                                                                                                                     
[20238] "Neonatal_Nursing"                                                                                                                                                     
[20239] "MSLN_Gene"                                                                                                                                                            
[20240] "Mesothelin"                                                                                                                                                           
[20241] "Obstetrical_Nursing"                                                                                                                                                  
[20242] "Palliative_Care_Nursing"                                                                                                                                              
[20243] "Pediatric_Nursing"                                                                                                                                                    
[20244] "WFDC2_Gene"                                                                                                                                                           
[20245] "Camp_Nursing"                                                                                                                                                         
[20246] "Epididymal_Secretory_Protein-E4"                                                                                                                                      
[20247] "Developmental_Disabilities_Nursing"                                                                                                                                   
[20248] "Epidemiology_Nursing"                                                                                                                                                 
[20249] "Transplant_Nursing"                                                                                                                                                   
[20250] "TSSC1_Gene"                                                                                                                                                           
[20251] "PHLDA2_Gene"                                                                                                                                                          
[20252] "ELF3_Gene"                                                                                                                                                            
[20253] "E74-Like_Factor-3"                                                                                                                                                    
[20254] "Restraining_Placental_Growth"                                                                                                                                         
[20255] "SLPI_Gene"                                                                                                                                                            
[20256] "WNT3_Gene"                                                                                                                                                            
[20257] "SLC5A5_Gene"                                                                                                                                                          
[20258] "WNT10B_Gene"                                                                                                                                                          
[20259] "Adipogenesis"                                                                                                                                                         
[20260] "CCL2_Gene"                                                                                                                                                            
[20261] "ZNF147_Gene"                                                                                                                                                          
[20262] "Small_Inducible_Cytokine-A2"                                                                                                                                          
[20263] "WNT1_Inducible_Signaling_Pathway_Protein-1"                                                                                                                           
[20264] "WISP1_Gene"                                                                                                                                                           
[20265] "Cytokine_Receptor_Gene"                                                                                                                                               
[20266] "TGFB3_Gene"                                                                                                                                                           
[20267] "Uterine_Swelling"                                                                                                                                                     
[20268] "BRCD2_Gene"                                                                                                                                                           
[20269] "SHFM1_Gene"                                                                                                                                                           
[20270] "Cell_Cycle_Gene"                                                                                                                                                      
[20271] "Cell_Cycle_Completion"                                                                                                                                                
[20272] "BRCATA_Gene"                                                                                                                                                          
[20273] "Whey_Protein"                                                                                                                                                         
[20274] "Signaling_Pathway_Gene"                                                                                                                                               
[20275] "Axin_2_Protein"                                                                                                                                                       
[20276] "G_Protein-Coupled_Receptor_Gene"                                                                                                                                      
[20277] "GPR54_Gene"                                                                                                                                                           
[20278] "NOVA2_Gene"                                                                                                                                                           
[20279] "FABP2_Gene"                                                                                                                                                           
[20280] "BCL2L2_Protein"                                                                                                                                                       
[20281] "Baculoviral_IAP_Repeat-Containing_Protein-1"                                                                                                                          
[20282] "XIAP-Associated_Factor-1"                                                                                                                                             
[20283] "Apoptotic_Protease_Activating_Factor-1"                                                                                                                               
[20284] "Baculoviral_IAP_Repeat-Containing_Protein-2"                                                                                                                          
[20285] "Alpha_Adrenergic_Receptor"                                                                                                                                            
[20286] "Alpha_Adrenergic_Receptor_Gene"                                                                                                                                       
[20287] "IAP_Family_Protein"                                                                                                                                                   
[20288] "Alpha-1B_Adrenergic_Receptor"                                                                                                                                         
[20289] "ADRA1B_Gene"                                                                                                                                                          
[20290] "AKT3_Gene"                                                                                                                                                            
[20291] "IAP_Family_Gene"                                                                                                                                                      
[20292] "Protein_Kinase-B_Gamma"                                                                                                                                               
[20293] "ANXA8_Gene"                                                                                                                                                           
[20294] "Annexin-A8_Protein"                                                                                                                                                   
[20295] "Rho_Guanine_Nucleotide_Exchange_Factor-1"                                                                                                                             
[20296] "ARHGEF1_Gene"                                                                                                                                                         
[20297] "ASCL1_Protein"                                                                                                                                                        
[20298] "ACSL1_Gene"                                                                                                                                                           
[20299] "Baculoviral_IAP_Repeat-Containing_Protein-3"                                                                                                                          
[20300] "Baculoviral_IAP_Repeat-Containing_Protein-4"                                                                                                                          
[20301] "AUH_Gene"                                                                                                                                                             
[20302] "Apollon"                                                                                                                                                              
[20303] "AU-RNA_Binding_Protein"                                                                                                                                               
[20304] "Livin"                                                                                                                                                                
[20305] "BAG1_Gene"                                                                                                                                                            
[20306] "BAG1_Protein"                                                                                                                                                         
[20307] "BRS3_Gene"                                                                                                                                                            
[20308] "Bombesin-Like_Receptor-3"                                                                                                                                             
[20309] "Cyclin-A2"                                                                                                                                                            
[20310] "CCNA2_Gene"                                                                                                                                                           
[20311] "CCNE2_Gene"                                                                                                                                                           
[20312] "Cyclin-E2"                                                                                                                                                            
[20313] "CDC25A_Gene"                                                                                                                                                          
[20314] "Cell_Division_Cycle-25A_Protein"                                                                                                                                      
[20315] "MCL-1_Protien"                                                                                                                                                        
[20316] "HRK_Protein"                                                                                                                                                          
[20317] "CHRM1_Gene"                                                                                                                                                           
[20318] "Muscarinic_Acetylcholine_Receptor-M1"                                                                                                                                 
[20319] "CHRM3_Gene"                                                                                                                                                           
[20320] "Muscarinic_Acetylcholine_Receptor-M3"                                                                                                                                 
[20321] "CHRM5_Gene"                                                                                                                                                           
[20322] "Muscarinic_Acetylcholine_Receptor-M5"                                                                                                                                 
[20323] "Epidermal_Growth_Factor_Superfamily_Protein"                                                                                                                          
[20324] "V-D-J_Recombination"                                                                                                                                                  
[20325] "Autoantigen"                                                                                                                                                          
[20326] "Amphiphysin"                                                                                                                                                          
[20327] "Fatty_Acid-Binding_Protein-3"                                                                                                                                         
[20328] "FABP1_Gene"                                                                                                                                                           
[20329] "FABP4_Gene"                                                                                                                                                           
[20330] "FABP5_Gene"                                                                                                                                                           
[20331] "Regulation_of_Exocytosis"                                                                                                                                             
[20332] "GTP_Binding"                                                                                                                                                          
[20333] "BRCA1_Associated_RING_Domain-1_Protein"                                                                                                                               
[20334] "Physiotherapy"                                                                                                                                                        
[20335] "Tumor_Suppressor_Protein"                                                                                                                                             
[20336] "Serine_Hydrolase"                                                                                                                                                     
[20337] "Biphenyl_Hydrolase-Like_Protein"                                                                                                                                      
[20338] "Ablation"                                                                                                                                                             
[20339] "Trefoil_Factor-1"                                                                                                                                                     
[20340] "CTNNB1_Gene"                                                                                                                                                          
[20341] "Cell_Adhesion_Molecule_Gene"                                                                                                                                          
[20342] "Physical_Examination"                                                                                                                                                 
[20343] "CD22_Gene"                                                                                                                                                            
[20344] "Cancer_Pain_Group"                                                                                                                                                    
[20345] "Pain_Assessment"                                                                                                                                                      
[20346] "Clinical_Assessment_Tool"                                                                                                                                             
[20347] "ALCAM_Gene"                                                                                                                                                           
[20348] "Pain_Assessment_Tool"                                                                                                                                                 
[20349] "Category_Rating_Scale"                                                                                                                                                
[20350] "PECAM1_Gene"                                                                                                                                                          
[20351] "CEACAM5_Gene"                                                                                                                                                         
[20352] "CD44_Gene"                                                                                                                                                            
[20353] "Choices_and_Control"                                                                                                                                                  
[20354] "Cordotomy"                                                                                                                                                            
[20355] "Deafferentation"                                                                                                                                                      
[20356] "CD34_Gene"                                                                                                                                                            
[20357] "NCAM1_Gene"                                                                                                                                                           
[20358] "Dermatome_Map"                                                                                                                                                        
[20359] "ICAM1_Gene"                                                                                                                                                           
[20360] "Disability"                                                                                                                                                           
[20361] "ICAM2_Gene"                                                                                                                                                           
[20362] "Discectomy"                                                                                                                                                           
[20363] "Discomfort_Scale_for_Patients_with_Dementia_of_the_Alzheimer_s_Type"                                                                                                  
[20364] "Distraction_and_Attention"                                                                                                                                            
[20365] "Electroanalgesia"                                                                                                                                                     
[20366] "ICAM3_Gene"                                                                                                                                                           
[20367] "DBCCR1_Protein"                                                                                                                                                       
[20368] "CD58_Gene"                                                                                                                                                            
[20369] "Protein_Acetylation"                                                                                                                                                  
[20370] "Protein_Dephosphorylation"                                                                                                                                            
[20371] "Suppression_of_Cancer_Cell_Invasion"                                                                                                                                  
[20372] "P-Cadherin"                                                                                                                                                           
[20373] "VE-Cadherin"                                                                                                                                                          
[20374] "H-Cadherin"                                                                                                                                                           
[20375] "Spinal_Cord_Stimulation"                                                                                                                                              
[20376] "Deep_Brain_Stimulation"                                                                                                                                               
[20377] "Peripheral_Nerve_Stimulation"                                                                                                                                         
[20378] "Peripheral_Electronic_Nerve_Stimulation"                                                                                                                              
[20379] "Percutaneous_Neuromodulation_Therapy"                                                                                                                                 
[20380] "Transcutaneous_Acupoint_Electrical_Stimulation"                                                                                                                       
[20381] "H-Wave_Therapy"                                                                                                                                                       
[20382] "Inferential_Current_Treatment"                                                                                                                                        
[20383] "Piezo-Electric_Current_Therapy"                                                                                                                                       
[20384] "Transcutaneous_Electrical_Nerve_Stimulation"                                                                                                                          
[20385] "ITGAL_Gene"                                                                                                                                                           
[20386] "Glycosylation"                                                                                                                                                        
[20387] "Protein_Methylation"                                                                                                                                                  
[20388] "Facial_Affective_Scale"                                                                                                                                               
[20389] "Fleming_Method_Relaxation"                                                                                                                                            
[20390] "Molecular_Folding"                                                                                                                                                    
[20391] "Nucleic_Acid_Folding"                                                                                                                                                 
[20392] "Cell_Signaling_Process"                                                                                                                                               
[20393] "SELP_Gene"                                                                                                                                                            
[20394] "Group_Therapy"                                                                                                                                                        
[20395] "SELE_Gene"                                                                                                                                                            
[20396] "Cell_Death_Signaling_Process"                                                                                                                                         
[20397] "Coagulation_Process"                                                                                                                                                  
[20398] "SELL_Gene"                                                                                                                                                            
[20399] "VTN_Gene"                                                                                                                                                             
[20400] "DNA_Replication_Proofreading"                                                                                                                                         
[20401] "Gene_Expression_Process"                                                                                                                                              
[20402] "Gene_Regulation"                                                                                                                                                      
[20403] "Epigenetic_Process"                                                                                                                                                   
[20404] "Post-Transcriptional_Regulation_Process"                                                                                                                              
[20405] "RNA_Polyadenylation_Regulation"                                                                                                                                       
[20406] "RNA_Polyadenylation_Inhibition"                                                                                                                                       
[20407] "Impairment"                                                                                                                                                           
[20408] "Interpretive_Therapy"                                                                                                                                                 
[20409] "Isometric_Exercise"                                                                                                                                                   
[20410] "Isotonic_Exercise"                                                                                                                                                    
[20411] "Isokinetic_Exercise"                                                                                                                                                  
[20412] "Intravenous_Patient-Controlled_Analgesia"                                                                                                                             
[20413] "Laminectomy"                                                                                                                                                          
[20414] "Actinotherapy"                                                                                                                                                        
[20415] "Low_Emission_Laser_Therapy"                                                                                                                                           
[20416] "Protein_Turnover"                                                                                                                                                     
[20417] "Cell_Stress_Process"                                                                                                                                                  
[20418] "Cellular_Stress"                                                                                                                                                      
[20419] "Cellular_Stress_Response"                                                                                                                                             
[20420] "DNA_Sequence_Alteration"                                                                                                                                              
[20421] "DNA_Sequence_Rearrangement"                                                                                                                                           
[20422] "Protein_Sequence_Alteration"                                                                                                                                          
[20423] "Multidisciplinary_Pain_Treatment_Center"                                                                                                                              
[20424] "Neural_Block"                                                                                                                                                         
[20425] "Neuraxial_Opioid_Analgesia"                                                                                                                                           
[20426] "Neurologic_Process"                                                                                                                                                   
[20427] "Nociception"                                                                                                                                                          
[20428] "Nociceptive_Impulse"                                                                                                                                                  
[20429] "Nociceptive_Reflex"                                                                                                                                                   
[20430] "Nociceptive_Stimulus"                                                                                                                                                 
[20431] "Transport_Process"                                                                                                                                                    
[20432] "Replication-Associated_Process"                                                                                                                                       
[20433] "Growth_Arrest-Specific_Protein-8"                                                                                                                                     
[20434] "Numeric_Rating_Scale"                                                                                                                                                 
[20435] "Opioid_Rotation"                                                                                                                                                      
[20436] "Pain_Map"                                                                                                                                                             
[20437] "Pain_Threshold"                                                                                                                                                       
[20438] "Pain_Tolerance"                                                                                                                                                       
[20439] "Infusion_Technique"                                                                                                                                                   
[20440] "Parenteral_Infusion"                                                                                                                                                  
[20441] "Patient_Self-Report"                                                                                                                                                  
[20442] "Pharmacologic_Management"                                                                                                                                             
[20443] "TNC_Gene"                                                                                                                                                             
[20444] "HSPB1_Gene"                                                                                                                                                           
[20445] "Preemptive_Analgesia"                                                                                                                                                 
[20446] "Quality_Adjusted_Life_Years"                                                                                                                                          
[20447] "Cell_Motility_Process"                                                                                                                                                
[20448] "Sedation"                                                                                                                                                             
[20449] "F3_Gene"                                                                                                                                                              
[20450] "Cell_Viability_Process"                                                                                                                                               
[20451] "Social_Isolation"                                                                                                                                                     
[20452] "Cell_Growth_Process"                                                                                                                                                  
[20453] "Cell_Division_Process"                                                                                                                                                
[20454] "Hyaluronan-Mediated_Motility_Receptor"                                                                                                                                
[20455] "Pain_Origin"                                                                                                                                                          
[20456] "Pain_Attribute"                                                                                                                                                       
[20457] "Pain_Nature"                                                                                                                                                          
[20458] "Previous_Pain_Treatment_Assessment"                                                                                                                                   
[20459] "M-Phase_Substage"                                                                                                                                                     
[20460] "Supportive_Therapy"                                                                                                                                                   
[20461] "Sympathetic_Block"                                                                                                                                                    
[20462] "Inflammation_Process"                                                                                                                                                 
[20463] "KITLG_Gene"                                                                                                                                                           
[20464] "TNFSF15_Gene"                                                                                                                                                         
[20465] "Tumor_Necrosis_Factor_Family_Gene"                                                                                                                                    
[20466] "Terminal_Sedation"                                                                                                                                                    
[20467] "Terminal_Illness"                                                                                                                                                     
[20468] "Therapeutic_Heat"                                                                                                                                                     
[20469] "Therapeutic_Cold"                                                                                                                                                     
[20470] "Traction"                                                                                                                                                             
[20471] "Visual_Analog_Scale"                                                                                                                                                  
[20472] "TNFRSF5_Gene"                                                                                                                                                         
[20473] "WHO_Analgesic_Method"                                                                                                                                                 
[20474] "Pain_Management_Method"                                                                                                                                               
[20475] "Multicellular_Process"                                                                                                                                                
[20476] "Rolfing"                                                                                                                                                              
[20477] "Ceiling_Effect"                                                                                                                                                       
[20478] "Single_Convention_on_Narcotic_Drugs"                                                                                                                                  
[20479] "Histogenesis"                                                                                                                                                         
[20480] "Physical_Dependence"                                                                                                                                                  
[20481] "Tolerance"                                                                                                                                                            
[20482] "Psychological_Dependence"                                                                                                                                             
[20483] "TNFSF5_Gene"                                                                                                                                                          
[20484] "Verbal_Rating_Scale"                                                                                                                                                  
[20485] "Wisconsin_Brief_Pain_Questionnaire"                                                                                                                                   
[20486] "McGill_Pain_Questionnaire"                                                                                                                                            
[20487] "Short-Form_McGill_Pain_Questionnaire"                                                                                                                                 
[20488] "Memorial_Pain_Questionnaire"                                                                                                                                          
[20489] "Patient_Outcome_Questionnaire"                                                                                                                                        
[20490] "Descriptor_Differential_Scale"                                                                                                                                        
[20491] "Metastasis_Suppressor_Protein"                                                                                                                                        
[20492] "KiSS1_Metastasis_Suppressor_Protein"                                                                                                                                  
[20493] "Integrated_Pain_Scale"                                                                                                                                                
[20494] "Myelopoiesis"                                                                                                                                                         
[20495] "TNFSF10_Gene"                                                                                                                                                         
[20496] "ADAM_Family_Protein"                                                                                                                                                  
[20497] "Developmental_Process"                                                                                                                                                
[20498] "TNFSF6_Gene"                                                                                                                                                          
[20499] "TNFSF4_Gene"                                                                                                                                                          
[20500] "Pain_Perception_Profile"                                                                                                                                              
[20501] "West_Haven-Yale_Multidimensional_Pain_Inventory"                                                                                                                      
[20502] "Unmet_Analgesic_Needs_Questionnaire"                                                                                                                                  
[20503] "City_of_Hope_Mayday_Pain_Resource_Center_Patient_Pain_Questionnaire"                                                                                                  
[20504] "Symptom_Specific_Assessment_Tool"                                                                                                                                     
[20505] "Baseline_Dyspnea_Index"                                                                                                                                               
[20506] "Quality_of_Life_in_Chronic_Lung_Disease"                                                                                                                              
[20507] "Medical_Research_Council_Dyspnea_Scale"                                                                                                                               
[20508] "ATS-DLD-78_Adult_Questionnaire"                                                                                                                                       
[20509] "Peptidase_Family-M12B"                                                                                                                                                
[20510] "Immunoglobulin_Binding_Protein"                                                                                                                                       
[20511] "Beta-Microseminoprotein"                                                                                                                                              
[20512] "ITGAM_Gene"                                                                                                                                                           
[20513] "TNF_Receptor-Associated_Factor-4_Protein"                                                                                                                             
[20514] "Beta-Microseminoprotein_Family"                                                                                                                                       
[20515] "TNF_Receptor_Family_Gene"                                                                                                                                             
[20516] "CD72_Gene"                                                                                                                                                            
[20517] "CHGA_Gene"                                                                                                                                                            
[20518] "Immune_Function_System"                                                                                                                                               
[20519] "SHBG_Gene"                                                                                                                                                            
[20520] "DNA_Repair_Protein"                                                                                                                                                   
[20521] "Nibrin"                                                                                                                                                               
[20522] "Aging-Related_Process"                                                                                                                                                
[20523] "Reproductive_Process"                                                                                                                                                 
[20524] "CAV1_Gene"                                                                                                                                                            
[20525] "Growth_Arrest_Specific_Protein"                                                                                                                                       
[20526] "Protein_or_Riboprotein_Complex"                                                                                                                                       
[20527] "MRE11-RAD50_Double-Strand_Break_Repair_Complex"                                                                                                                       
[20528] "NBS1_Gene"                                                                                                                                                            
[20529] "CLIC4_Gene"                                                                                                                                                           
[20530] "Chloride_Intracellular_Channel-4"                                                                                                                                     
[20531] "NOVA_Family"                                                                                                                                                          
[20532] "Neuro-Oncological_Ventral_Antigen-1"                                                                                                                                  
[20533] "Nucleoporin"                                                                                                                                                          
[20534] "Nucleoporin-98kD"                                                                                                                                                     
[20535] "NPM1_Gene"                                                                                                                                                            
[20536] "Tumor_Expansion"                                                                                                                                                      
[20537] "TSSC5_Protein"                                                                                                                                                        
[20538] "Tumor-Associated_Process"                                                                                                                                             
[20539] "Metabolic_Process_Organismal"                                                                                                                                         
[20540] "Physiologic_Reproductive_Process"                                                                                                                                     
[20541] "BCL2-Binding_Protein"                                                                                                                                                 
[20542] "BCL2-Antagonist_Killer-1"                                                                                                                                             
[20543] "BCL2-Related_Protein_1_Long_Isoform"                                                                                                                                  
[20544] "BCL2-Related_Protein_1_Short_Isoform"                                                                                                                                 
[20545] "BCL2-Related_Protein-11"                                                                                                                                              
[20546] "Immune_Function_Subcellular"                                                                                                                                          
[20547] "BCL2-Related-2_Protein"                                                                                                                                               
[20548] "Intermediary_Metabolism"                                                                                                                                              
[20549] "BH3_Interacting_Domain_Death_Agonist_Protein"                                                                                                                         
[20550] "Chromogranin_Gene"                                                                                                                                                    
[20551] "CHGB_Gene"                                                                                                                                                            
[20552] "Viral_Reverse_Transcription"                                                                                                                                          
[20553] "BCL2-Interacting_Killer_Protein"                                                                                                                                      
[20554] "Organic_Cation_Transporter"                                                                                                                                           
[20555] "SCG2_Gene"                                                                                                                                                            
[20556] "Harakiri"                                                                                                                                                             
[20557] "Prohibitin"                                                                                                                                                           
[20558] "BRCA1_Associated_RING_Domain_Protein_1"                                                                                                                               
[20559] "RAD51_Homolog-C_Protein"                                                                                                                                              
[20560] "Ribosomal_Protein"                                                                                                                                                    
[20561] "Ribosomal_Protein-L13"                                                                                                                                                
[20562] "Ribonucleotide_Reductase_Subunit"                                                                                                                                     
[20563] "Ribonucleoside-Diphosphate_Reductase-M1_Chain"                                                                                                                        
[20564] "Calcium_Binding_Protein"                                                                                                                                              
[20565] "S100_Calcium_Binding_Protein-A2"                                                                                                                                      
[20566] "Calcium_Binding"                                                                                                                                                      
[20567] "Synuclein_Family"                                                                                                                                                     
[20568] "Synuclein_Gamma"                                                                                                                                                      
[20569] "Stromal_Interaction_Molecule-1"                                                                                                                                       
[20570] "PIK3CA_Gene"                                                                                                                                                          
[20571] "DCK_Gene"                                                                                                                                                             
[20572] "MAP2K1_Gene"                                                                                                                                                          
[20573] "RIPK1_Gene"                                                                                                                                                           
[20574] "Anchorage-Independent_Growth"                                                                                                                                         
[20575] "Transforming_Acidic_Coiled-Coil_Containing_Protein-1"                                                                                                                 
[20576] "MAPK3_Gene"                                                                                                                                                           
[20577] "MAPK1_Gene"                                                                                                                                                           
[20578] "MAPK8_Gene"                                                                                                                                                           
[20579] "TYMS_Gene"                                                                                                                                                            
[20580] "G1-S_Arrest"                                                                                                                                                          
[20581] "Trefoil_Family"                                                                                                                                                       
[20582] "MGMT_Gene"                                                                                                                                                            
[20583] "TSG101_Gene"                                                                                                                                                          
[20584] "CKB_Gene"                                                                                                                                                             
[20585] "TNKS_Gene"                                                                                                                                                            
[20586] "TYRP1_Gene"                                                                                                                                                           
[20587] "Tumor_Susceptibility_Gene-101_Protein"                                                                                                                                
[20588] "PSMD10_Gene"                                                                                                                                                          
[20589] "Translation_Process_Gene"                                                                                                                                             
[20590] "Replication_Process"                                                                                                                                                  
[20591] "Vacuolar_Protein_Sorting"                                                                                                                                             
[20592] "Ubiquitinated_Protein_Degradation"                                                                                                                                    
[20593] "HIV_Budding"                                                                                                                                                          
[20594] "TSSC1_Protein"                                                                                                                                                        
[20595] "TSSC3_Protein"                                                                                                                                                        
[20596] "WNT-3_Protein"                                                                                                                                                        
[20597] "HPR_Gene"                                                                                                                                                             
[20598] "WNT-10B_Protein"                                                                                                                                                      
[20599] "RTN4_Gene"                                                                                                                                                            
[20600] "Zinc_Finger_Protein-147"                                                                                                                                              
[20601] "CENPF_Gene"                                                                                                                                                           
[20602] "ATP_Binding_Cassette_Transporter-G2"                                                                                                                                  
[20603] "E3_Ubiquitin_Ligase"                                                                                                                                                  
[20604] "TRIM_Family"                                                                                                                                                          
[20605] "_14-3-3_Family"                                                                                                                                                       
[20606] "Breast_Cancer_Suppressor-2"                                                                                                                                           
[20607] "RTN1_Gene"                                                                                                                                                            
[20608] "Neuroendocrine-Specific_Protein"                                                                                                                                      
[20609] "Death_Domain-Associated_Protein-6"                                                                                                                                    
[20610] "MCAM_Gene"                                                                                                                                                            
[20611] "BRCATA_Protein"                                                                                                                                                       
[20612] "ITGB2_Gene"                                                                                                                                                           
[20613] "ABCB6_Gene"                                                                                                                                                           
[20614] "ABI2_Gene"                                                                                                                                                            
[20615] "ACK1_Gene"                                                                                                                                                            
[20616] "ACVR1_Gene"                                                                                                                                                           
[20617] "ACVR1B_Gene"                                                                                                                                                          
[20618] "ACVRL1_Gene"                                                                                                                                                          
[20619] "Ontology"                                                                                                                                                             
[20620] "ACVR2_Gene"                                                                                                                                                           
[20621] "Activin-A_Type-II_Receptor"                                                                                                                                           
[20622] "ACVR2B_Gene"                                                                                                                                                          
[20623] "Activin-A_Type-IIB_Receptor"                                                                                                                                          
[20624] "Metalloproteinase_Gene"                                                                                                                                               
[20625] "ADAMTS1_Gene"                                                                                                                                                         
[20626] "ADAMTS1_Protein"                                                                                                                                                      
[20627] "ADAMTS9_Gene"                                                                                                                                                         
[20628] "ADAMTS9_Protein"                                                                                                                                                      
[20629] "JUP_Gene"                                                                                                                                                             
[20630] "Enzyme_Gene"                                                                                                                                                          
[20631] "Lyase_Gene"                                                                                                                                                           
[20632] "ADCY9_Gene"                                                                                                                                                           
[20633] "ADRA1A_Gene"                                                                                                                                                          
[20634] "Alpha-1A_Adrenergic_Receptor"                                                                                                                                         
[20635] "ADRA2A_Gene"                                                                                                                                                          
[20636] "Alpha-2A_Adrenergic_Receptor"                                                                                                                                         
[20637] "ADRA2B_Gene"                                                                                                                                                          
[20638] "Alpha-2B_Adrenergic_Receptor"                                                                                                                                         
[20639] "CD14_Gene"                                                                                                                                                            
[20640] "CD28_Gene"                                                                                                                                                            
[20641] "Beta_Adrenergic_Receptor_Gene"                                                                                                                                        
[20642] "ADRB2_Gene"                                                                                                                                                           
[20643] "LCP1_Gene"                                                                                                                                                            
[20644] "Ligand_Binding_Protein_Gene"                                                                                                                                          
[20645] "VCL_Gene"                                                                                                                                                             
[20646] "Beta-2_Adrenergic_Receptor"                                                                                                                                           
[20647] "RNA_Binding_Protein"                                                                                                                                                  
[20648] "Mitochondrial_ABC_Protein-3"                                                                                                                                          
[20649] "ABL-Interactor_2_Protein"                                                                                                                                             
[20650] "ASCL1_Gene"                                                                                                                                                           
[20651] "ANP32B_Gene"                                                                                                                                                          
[20652] "APS_Gene"                                                                                                                                                             
[20653] "APCL_Gene"                                                                                                                                                            
[20654] "AKAP9_Gene"                                                                                                                                                           
[20655] "AKAP12_Gene"                                                                                                                                                          
[20656] "AKAP13_Gene"                                                                                                                                                          
[20657] "ALDH1A2_Gene"                                                                                                                                                         
[20658] "AKR7A2_Gene"                                                                                                                                                          
[20659] "APRIN_Gene"                                                                                                                                                           
[20660] "ANGPT1_Gene"                                                                                                                                                          
[20661] "ANGPT2_Gene"                                                                                                                                                          
[20662] "AMHR2_Gene"                                                                                                                                                           
[20663] "ASE-1_Gene"                                                                                                                                                           
[20664] "ALOX15_Gene"                                                                                                                                                          
[20665] "ARMET_Gene"                                                                                                                                                           
[20666] "Arrestin_Beta_1_Gene"                                                                                                                                                 
[20667] "AMSH_Gene"                                                                                                                                                            
[20668] "ARHH_Gene"                                                                                                                                                            
[20669] "Achaete-Scute_Complex-Like-1_Protein"                                                                                                                                 
[20670] "Protein_with_Unknown_or_Unclassified_Function"                                                                                                                        
[20671] "APS_Protein"                                                                                                                                                          
[20672] "Adenomatous_Polyposis_Coli_Like_Protein"                                                                                                                              
[20673] "A_Kinase_Anchor_Protein-9"                                                                                                                                            
[20674] "A_Kinase_Anchor_Protein-12"                                                                                                                                           
[20675] "EZH2_Gene"                                                                                                                                                            
[20676] "Computerized_Thermal_Imaging"                                                                                                                                         
[20677] "A_Kinase_Anchor_Protein-13"                                                                                                                                           
[20678] "Aldehyde_Dehydrogenase-1A2"                                                                                                                                           
[20679] "Aldo-Keto_Reductase-7"                                                                                                                                                
[20680] "APRIN_Protein"                                                                                                                                                        
[20681] "Annexin-A5_Protein"                                                                                                                                                   
[20682] "Anti-Mullerian_Hormone_Receptor_Type-II"                                                                                                                              
[20683] "CD3-Epsilon-Associated_Protein"                                                                                                                                       
[20684] "Arachidonate_15-Lipoxygenase"                                                                                                                                         
[20685] "ARMET_Protein"                                                                                                                                                        
[20686] "Arrestin_Beta_1_Protein"                                                                                                                                              
[20687] "AMSH_Protein"                                                                                                                                                         
[20688] "RAS_Homolog_Gene_Family_Member-H_Protein"                                                                                                                             
[20689] "Activated-p21cdc42Hs_Kinase"                                                                                                                                          
[20690] "Scanning_Transmission_Electron_Microscopy"                                                                                                                            
[20691] "BMP10_Gene"                                                                                                                                                           
[20692] "Growth_Factor_Gene"                                                                                                                                                   
[20693] "Transforming_Growth_Factor-Beta_Family_Gene"                                                                                                                          
[20694] "Bone_Morphogenetic_Protein-10"                                                                                                                                        
[20695] "BMP15_Gene"                                                                                                                                                           
[20696] "Bone_Morphogenetic_Protein-15"                                                                                                                                        
[20697] "BMP2_Gene"                                                                                                                                                            
[20698] "Bone_Morphogenetic_Protein-2"                                                                                                                                         
[20699] "BMP3_Gene"                                                                                                                                                            
[20700] "Osteogenic_Bone_Morphogenetic_Protein-3"                                                                                                                              
[20701] "BMP5_Gene"                                                                                                                                                            
[20702] "Bone_Morphogenetic_Protein-5"                                                                                                                                         
[20703] "BMP6_Gene"                                                                                                                                                            
[20704] "Bone_Morphogenetic_Protein-6"                                                                                                                                         
[20705] "BMP7_Gene"                                                                                                                                                            
[20706] "Bone_Morphogenetic_Protein-7"                                                                                                                                         
[20707] "BMP8_Gene"                                                                                                                                                            
[20708] "Bone_Morphogenetic_Protein-8"                                                                                                                                         
[20709] "CD2_Gene"                                                                                                                                                             
[20710] "CD4_Gene"                                                                                                                                                             
[20711] "CD80_Gene"                                                                                                                                                            
[20712] "Receptor_Serine-Threonine_Kinase_Gene"                                                                                                                                
[20713] "Bone_Morphogenetic_Protein_Receptor_Gene"                                                                                                                             
[20714] "BMPR1A_Gene"                                                                                                                                                          
[20715] "Bone_Morphogenetic_Protein_Receptor_Type-IA"                                                                                                                          
[20716] "BMPR2_Gene"                                                                                                                                                           
[20717] "Bone_Morphogenetic_Protein_Receptor_Type-II"                                                                                                                          
[20718] "BMX_Gene"                                                                                                                                                             
[20719] "CD8B1_Gene"                                                                                                                                                           
[20720] "BMX_Non-Receptor_Tyrosine_Kinase"                                                                                                                                     
[20721] "BNIP3L_Gene"                                                                                                                                                          
[20722] "Adenovirus_E1b19kD-Binding_Protein-B5"                                                                                                                                
[20723] "BRD2_Gene"                                                                                                                                                            
[20724] "Bromodomain_Containing_Protein-2"                                                                                                                                     
[20725] "BRDG1_Gene"                                                                                                                                                           
[20726] "BCR_Downstream_Signaling-1_Protein"                                                                                                                                   
[20727] "BTG2_Gene"                                                                                                                                                            
[20728] "BTG2_Protein"                                                                                                                                                         
[20729] "ADRBK1_Gene"                                                                                                                                                          
[20730] "Beta_Adrenergic_Receptor_Kinase-1"                                                                                                                                    
[20731] "ADRBK2_Gene"                                                                                                                                                          
[20732] "Beta_Adrenergic_Receptor_Kinase-2"                                                                                                                                    
[20733] "AF5Q31_Gene"                                                                                                                                                          
[20734] "AF5Q31_Protein"                                                                                                                                                       
[20735] "AGTR2_Gene"                                                                                                                                                           
[20736] "Angiotensin_Receptor-2"                                                                                                                                               
[20737] "AIM1_Gene"                                                                                                                                                            
[20738] "Absent_in_Melanoma_1_Protein"                                                                                                                                         
[20739] "AIM2_Gene"                                                                                                                                                            
[20740] "Absent_in_Melanoma_2_Protein"                                                                                                                                         
[20741] "RNR1_Gene"                                                                                                                                                            
[20742] "RPL8_Gene"                                                                                                                                                            
[20743] "Ribosomal_Protein-L8"                                                                                                                                                 
[20744] "RPL19_Gene"                                                                                                                                                           
[20745] "Ribosomal_Protein-L19"                                                                                                                                                
[20746] "RPL29_Gene"                                                                                                                                                           
[20747] "Ribosomal_Protein-L29"                                                                                                                                                
[20748] "CTBP1_Gene"                                                                                                                                                           
[20749] "C-Terminal_Binding_Protein-1"                                                                                                                                         
[20750] "MSH4_Gene"                                                                                                                                                            
[20751] "MutS_Homolog-4_Protein"                                                                                                                                               
[20752] "SPO11_Gene"                                                                                                                                                           
[20753] "VEGF_Gene"                                                                                                                                                            
[20754] "SPO11_Homolog_Protein"                                                                                                                                                
[20755] "VEGFC_Gene"                                                                                                                                                           
[20756] "VIP_Gene"                                                                                                                                                             
[20757] "CCNE1_Gene"                                                                                                                                                           
[20758] "VIPR1_Gene"                                                                                                                                                           
[20759] "Cyclin-E1"                                                                                                                                                            
[20760] "APEX_Nuclease"                                                                                                                                                        
[20761] "WHSC1_Gene"                                                                                                                                                           
[20762] "WISP2_Gene"                                                                                                                                                           
[20763] "WISP3_Gene"                                                                                                                                                           
[20764] "WNT2B_Gene"                                                                                                                                                           
[20765] "WNT6_Gene"                                                                                                                                                            
[20766] "WNT10A_Gene"                                                                                                                                                          
[20767] "Class-II_AP-Endonuclease"                                                                                                                                             
[20768] "Apurinic-Apyrimidinic_Endonuclease-2"                                                                                                                                 
[20769] "WNT11_Gene"                                                                                                                                                           
[20770] "WNT14_Gene"                                                                                                                                                           
[20771] "WSX1_Gene"                                                                                                                                                            
[20772] "XCR1_Gene"                                                                                                                                                            
[20773] "YARS_Gene"                                                                                                                                                            
[20774] "YWHAQ_Gene"                                                                                                                                                           
[20775] "Protein_Kinase-ATR"                                                                                                                                                   
[20776] "ZFP36L2_Gene"                                                                                                                                                         
[20777] "ZNF151_Gene"                                                                                                                                                          
[20778] "ZNF217_Gene"                                                                                                                                                          
[20779] "Chemokine_C_Motif_XC_Receptor_1"                                                                                                                                      
[20780] "Class-I_Cytokine_Receptor"                                                                                                                                            
[20781] "Tyrosyl-tRNA_Synthetase"                                                                                                                                              
[20782] "Excision_Repair_Cross-Complementing-1_Protein"                                                                                                                        
[20783] "DNA_Repair_Endonuclease"                                                                                                                                              
[20784] "Ubiquitin_Specific_Protease-6"                                                                                                                                        
[20785] "Ubiquitin_Specific_Protease-8"                                                                                                                                        
[20786] "Vascular_Endothelial_Growth_Factor-C"                                                                                                                                 
[20787] "Vasoactive_Intestinal_Peptide"                                                                                                                                        
[20788] "Vasoactive_Intestinal_Peptide_Receptor-1"                                                                                                                             
[20789] "VAV3_Protein"                                                                                                                                                         
[20790] "WNT1_Inducible_Signaling_Pathway_Protein-2"                                                                                                                           
[20791] "DNA_Excision_Repair_Protein-ERCC2"                                                                                                                                    
[20792] "WNT1_Inducible_Signaling_Pathway_Protein-3"                                                                                                                           
[20793] "WNT2B_Protein"                                                                                                                                                        
[20794] "WNT6_Protein"                                                                                                                                                         
[20795] "WNT10A_Protein"                                                                                                                                                       
[20796] "WNT11_Protein"                                                                                                                                                        
[20797] "DNA_Excision_Repair_Protein-ERCC3"                                                                                                                                    
[20798] "WNT14_Protein"                                                                                                                                                        
[20799] "Wolf-Hirschhorn_Syndrome_Candidate-1_Protein"                                                                                                                         
[20800] "YWHAQ_Protein"                                                                                                                                                        
[20801] "EGF-Response_Factor-2"                                                                                                                                                
[20802] "Zinc_Finger_Protein-151"                                                                                                                                              
[20803] "Zinc_Finger_Protein-217"                                                                                                                                              
[20804] "DNA_Excision_Repair_Protein-ERCC4"                                                                                                                                    
[20805] "DNA_Excision_Repair_Protein-ERCC5"                                                                                                                                    
[20806] "DNA_Excision_Repair_Protein-ERCC6"                                                                                                                                    
[20807] "Exonuclease-1"                                                                                                                                                        
[20808] "DNA_Ligase-IV"                                                                                                                                                        
[20809] "DNA_Mismatch_Repair_Protein-MLH1"                                                                                                                                     
[20810] "DNA_Mismatch_Repair_Protein-MLH3"                                                                                                                                     
[20811] "DNA_Mismatch_Repair_Protein-MSH2"                                                                                                                                     
[20812] "DNA_Mismatch_Repair_Protein-MSH3"                                                                                                                                     
[20813] "DNA_Mismatch_Repair_Protein-MSH6"                                                                                                                                     
[20814] "TRAF6_Gene"                                                                                                                                                           
[20815] "TRAG3_Gene"                                                                                                                                                           
[20816] "Oncogenesis"                                                                                                                                                          
[20817] "TRC8_Gene"                                                                                                                                                            
[20818] "TRIM_Gene"                                                                                                                                                            
[20819] "TRIO_Gene"                                                                                                                                                            
[20820] "Eight-Oxoguanine_DNA_Glycosylase"                                                                                                                                     
[20821] "TRIP10_Gene"                                                                                                                                                          
[20822] "DNA_Mismatch_Repair_Protein-PMS1"                                                                                                                                     
[20823] "Acrosin_Binding_Protein"                                                                                                                                              
[20824] "DNA_Mismatch_Repair_Protein-PMS2"                                                                                                                                     
[20825] "Relative"                                                                                                                                                             
[20826] "First_Degree_Relative"                                                                                                                                                
[20827] "AGR2_Protein"                                                                                                                                                         
[20828] "Protein_Kinase_DNA-Activated_Catalytic_Subunit"                                                                                                                       
[20829] "ANP32C_Protein"                                                                                                                                                       
[20830] "ANP32D_Protein"                                                                                                                                                       
[20831] "Amyloid_Beta_Precursor_Protein-Binding_Protein_2"                                                                                                                     
[20832] "RHO-Related_GTP-Binding_Protein_RHOI"                                                                                                                                 
[20833] "Axin-2_Protein"                                                                                                                                                       
[20834] "Transaminase"                                                                                                                                                         
[20835] "BRCA1_Associated_Protein-1"                                                                                                                                           
[20836] "Breast_Cancer_Anti-Estrogen_Resistance-1_Protein"                                                                                                                     
[20837] "Mitotic_Spindle_Checkpoint"                                                                                                                                           
[20838] "Breast_Cancer_Anti-Estrogen_Resistance-2_Protein"                                                                                                                     
[20839] "BUB1_Gene"                                                                                                                                                            
[20840] "BUB1_Protein"                                                                                                                                                         
[20841] "Breast_Cancer_Anti-Estrogen_Resistance-3_Protein"                                                                                                                     
[20842] "Breast_Carcinoma_Amplified_Sequence-1_Protein"                                                                                                                        
[20843] "Breast_Carcinoma_Amplified_Sequence-2_Protein"                                                                                                                        
[20844] "Breast_Carcinoma_Amplified_Sequence-3_Protein"                                                                                                                        
[20845] "Breast_Carcinoma_Amplified_Sequence-4_Protein"                                                                                                                        
[20846] "BRCD1_Protein"                                                                                                                                                        
[20847] "BCPR_Protein"                                                                                                                                                         
[20848] "BC-2_Protein"                                                                                                                                                         
[20849] "BRCA3_Protein"                                                                                                                                                        
[20850] "Breast_Cancer_Antigen_NY-BR-1_Protein"                                                                                                                                
[20851] "BRMS1_Protein"                                                                                                                                                        
[20852] "COX7A2L_Protein"                                                                                                                                                      
[20853] "RHO-GTPase-Activating_Protein-7"                                                                                                                                      
[20854] "C22orf19_Gene"                                                                                                                                                        
[20855] "Epithelial_Stromal_Interaction-1_Protein"                                                                                                                             
[20856] "FBXW7_Protein"                                                                                                                                                        
[20857] "GAGED3_Protein"                                                                                                                                                       
[20858] "Temporal_Modifier"                                                                                                                                                    
[20859] "NF2-Meningioma_Region_Protein-pK1-3"                                                                                                                                  
[20860] "Glutaminase"                                                                                                                                                          
[20861] "Calcium-Activated_Chloride_Channel-2"                                                                                                                                 
[20862] "Complement_Component_Gene"                                                                                                                                            
[20863] "Complement_Activation"                                                                                                                                                
[20864] "Hypoxia_Up-Regulated-1_Protein"                                                                                                                                       
[20865] "C3_Gene"                                                                                                                                                              
[20866] "Host_Defense"                                                                                                                                                         
[20867] "Complement_Component_Protein"                                                                                                                                         
[20868] "Interleukin-24"                                                                                                                                                       
[20869] "MLN51_Protein"                                                                                                                                                        
[20870] "NY-BR-20_Protein"                                                                                                                                                     
[20871] "Complement_Component-3"                                                                                                                                               
[20872] "NY-BR-84_Protein"                                                                                                                                                     
[20873] "OBTP_Protein"                                                                                                                                                         
[20874] "PHEMX_Protein"                                                                                                                                                        
[20875] "RBBP1L1_Protein"                                                                                                                                                      
[20876] "Small_Breast_Epithelial_Mucin"                                                                                                                                        
[20877] "TACC2_Protein"                                                                                                                                                        
[20878] "TRAF4_Protein"                                                                                                                                                        
[20879] "TSSC4_Protein"                                                                                                                                                        
[20880] "WFDC1_Protein"                                                                                                                                                        
[20881] "WNT4_Protein"                                                                                                                                                         
[20882] "C5_Gene"                                                                                                                                                              
[20883] "Complement_Component-5"                                                                                                                                               
[20884] "CALM1_Gene"                                                                                                                                                           
[20885] "Healthcare_Facility"                                                                                                                                                  
[20886] "Meiotic_Recombination"                                                                                                                                                
[20887] "RAD54-Like_Protein"                                                                                                                                                   
[20888] "TRF1-Interacting_Nuclear_Protein-2"                                                                                                                                   
[20889] "DNA_Topoisomerase-II_Binding_Protein"                                                                                                                                 
[20890] "Three_Prime-Five_Prime_Exonuclease"                                                                                                                                   
[20891] "Three_Prime_Repair_Exonuclease-1"                                                                                                                                     
[20892] "Telomere_Shortening"                                                                                                                                                  
[20893] "OSM_Gene"                                                                                                                                                             
[20894] "Cytokine_Gene"                                                                                                                                                        
[20895] "FLT3LG_Gene"                                                                                                                                                          
[20896] "Three_Prime_Repair_Exonuclease_2"                                                                                                                                     
[20897] "TNFRSF1B_Gene"                                                                                                                                                        
[20898] "TNFRSF1A_Gene"                                                                                                                                                        
[20899] "TNFRSF6_Gene"                                                                                                                                                         
[20900] "Deubiquitination"                                                                                                                                                     
[20901] "Deubiquitinating_Enzyme"                                                                                                                                              
[20902] "Ubiquitin_C-Terminal_Hydrolase"                                                                                                                                       
[20903] "TNFRSF10A_Gene"                                                                                                                                                       
[20904] "Three_Prime_Repair_Exonuclease-2"                                                                                                                                     
[20905] "TNFRSF10B_Gene"                                                                                                                                                       
[20906] "EPOR_Gene"                                                                                                                                                            
[20907] "IL2RA_Gene"                                                                                                                                                           
[20908] "Xeroderma_Pigmentosum_Complementation_Group-A_Protein"                                                                                                                
[20909] "X-Ray_Repair_Cross_Complementing_Protein-1"                                                                                                                           
[20910] "Single_Strand_Break_Repair"                                                                                                                                           
[20911] "X-Ray_Repair_Cross_Complementing_Protein-2"                                                                                                                           
[20912] "CD209_Gene"                                                                                                                                                           
[20913] "X-Ray_Repair_Cross_Complementing_Protein-3"                                                                                                                           
[20914] "X-Ray_Repair_Cross_Complementing_Protein-4"                                                                                                                           
[20915] "RARA_Gene"                                                                                                                                                            
[20916] "Peptide_Transport"                                                                                                                                                    
[20917] "TAP1_Gene"                                                                                                                                                            
[20918] "ABC_Transporter-MHC1"                                                                                                                                                 
[20919] "Neuronal_Transmission"                                                                                                                                                
[20920] "Regulation_of_Cell_Size"                                                                                                                                              
[20921] "AFP_Gene"                                                                                                                                                             
[20922] "TAP2_Gene"                                                                                                                                                            
[20923] "ABC_Transporter-MHC2"                                                                                                                                                 
[20924] "TF_Gene"                                                                                                                                                              
[20925] "CAMLG_Gene"                                                                                                                                                           
[20926] "Calcium_Signaling"                                                                                                                                                    
[20927] "Calcium_Modulating_Ligand"                                                                                                                                            
[20928] "Docking_Protein"                                                                                                                                                      
[20929] "CAV2_Gene"                                                                                                                                                            
[20930] "Caveolin-2"                                                                                                                                                           
[20931] "Polyubiquitination"                                                                                                                                                   
[20932] "Monoubiquitination"                                                                                                                                                   
[20933] "CBLB_Gene"                                                                                                                                                            
[20934] "Signal_Transduction_Protein-CBLB"                                                                                                                                     
[20935] "G_Protein-Coupled_Receptor_Signaling"                                                                                                                                 
[20936] "CCBP2_Gene"                                                                                                                                                           
[20937] "Chemokine_Binding_Protein_2"                                                                                                                                          
[20938] "Thiopurine_S-Methyltransferase"                                                                                                                                       
[20939] "TPMT_Gene"                                                                                                                                                            
[20940] "CCKBR_Gene"                                                                                                                                                           
[20941] "CYP2C9_Gene"                                                                                                                                                          
[20942] "Cholecystokinin-B_Receptor"                                                                                                                                           
[20943] "Microanatomy"                                                                                                                                                         
[20944] "Mouse_Neuroglia_Neoplasm"                                                                                                                                             
[20945] "Mouse_Lobular_Neoplasm"                                                                                                                                               
[20946] "Mouse_Lymphoma"                                                                                                                                                       
[20947] "Mouse_Sarcoma"                                                                                                                                                        
[20948] "Mouse_Leukemia"                                                                                                                                                       
[20949] "Mouse_Giant_Cell_Neoplasm"                                                                                                                                            
[20950] "Mouse_Mixed_Mesodermal_Tumor"                                                                                                                                         
[20951] "Mouse_Malignant_Mixed_Mesodermal_Tumor"                                                                                                                               
[20952] "Mouse_Carcinoid_Tumor"                                                                                                                                                
[20953] "Mouse_Squamous_Cell_Carcinoma"                                                                                                                                        
[20954] "Mouse_Undifferentiated_Carcinoma"                                                                                                                                     
[20955] "Mouse_Small_Cell_Undifferentiated_Carcinoma"                                                                                                                          
[20956] "Mouse_Large_Cell_Undifferentiated_Carcinoma"                                                                                                                          
[20957] "Mouse_Spindle_Cell_Neoplasm"                                                                                                                                          
[20958] "Mouse_Intraepithelial_Neoplasia"                                                                                                                                      
[20959] "Mouse_Liposarcoma"                                                                                                                                                    
[20960] "Mouse_Benign_Mesenchymal_Neoplasm"                                                                                                                                    
[20961] "Mouse_Malignant_Mesenchymal_Neoplasm"                                                                                                                                 
[20962] "Mouse_Hemangiopericytoma"                                                                                                                                             
[20963] "Mouse_Mesothelioma"                                                                                                                                                   
[20964] "Mouse_Angioma"                                                                                                                                                        
[20965] "Mouse_Leiomyoma"                                                                                                                                                      
[20966] "Mouse_Fibroma"                                                                                                                                                        
[20967] "Mouse_Lipoma"                                                                                                                                                         
[20968] "Mouse_Myoepithelioma"                                                                                                                                                 
[20969] "Mouse_Mixed_Neoplasm"                                                                                                                                                 
[20970] "Mouse_Luminal_Carcinoma"                                                                                                                                              
[20971] "Mouse_Basal_Cell_Neoplasm"                                                                                                                                            
[20972] "Mouse_Plasma_Cell_Neoplasm"                                                                                                                                           
[20973] "Mouse_B_Cell_Neoplasms"                                                                                                                                               
[20974] "Mouse_T_Cell_Neoplasms"                                                                                                                                               
[20975] "Mouse_Plasmacytoma"                                                                                                                                                   
[20976] "Mouse_Mast_Cell_Neoplasm"                                                                                                                                             
[20977] "Mouse_Granular_Cell_Neoplasm"                                                                                                                                         
[20978] "Mouse_Hibernoma"                                                                                                                                                      
[20979] "Mouse_Stromal_Neoplasm"                                                                                                                                               
[20980] "Mouse_Clear_Cell_Neoplasm"                                                                                                                                            
[20981] "Mouse_Pathologic_Diagnoses"                                                                                                                                           
[20982] "Inflammatory_Conditions_of_the_Mouse_Mammary_Gland"                                                                                                                   
[20983] "Mastitis_of_the_Mouse_Mammary_Gland"                                                                                                                                  
[20984] "Abscess_of_the_Mouse_Mammary_Gland"                                                                                                                                   
[20985] "Granuloma_of_the_Mouse_Mammary_Gland"                                                                                                                                 
[20986] "Fat_Necrosis_of_the_Mouse_Mammary_Gland"                                                                                                                              
[20987] "Duct_Ectasia_of_the_Mouse_Mammary_Gland"                                                                                                                              
[20988] "Fibrosis_NOS_of_the_Mouse_Mammary_Gland"                                                                                                                              
[20989] "Non-proliferative_Developmental_Conditions_of_the_Mouse_Mammary_Gland"                                                                                                
[20990] "Aplasia_of_the_Mouse_Mammary_Gland"                                                                                                                                   
[20991] "Hypoplasia_of_the_Mouse_Mammary_Gland"                                                                                                                                
[20992] "Ductal_Hypoplasia_of_the_Mouse_Mammary_Gland"                                                                                                                         
[20993] "Lobuloacinar_Hypoplasia_of_the_Mouse_Mammary_Gland"                                                                                                                   
[20994] "Terminal_End_Bud_Hypoplasia_of_the_Mouse_Mammary_Gland"                                                                                                               
[20995] "Non-Neoplastic_Proliferation_of_the_Mouse_Mammary_Gland"                                                                                                              
[20996] "Hyperplasia_of_the_Mouse_Mammary_Gland"                                                                                                                               
[20997] "Diffuse_Hyperplasia_of_the_Mouse_Mammary_Gland"                                                                                                                       
[20998] "Physiological_Diffuse_Hyperplasia_of_the_Mouse_Mammary_Gland"                                                                                                         
[20999] "Non-physiological_Diffuse_Hyperplasia_of_the_Mouse_Mammary_Gland"                                                                                                     
[21000] "Focal_Hyperplasias_of_the_Mouse_Mammary_Gland"                                                                                                                        
[21001] "Inflammatory_Nodule_of_the_Mouse_Mammary_Gland"                                                                                                                       
[21002] "Squamous_Nodule_of_the_Mouse_Mammary_Gland"                                                                                                                           
[21003] "Other_Focal_Hyperplasias_of_the_Mouse_Mammary_Gland"                                                                                                                  
[21004] "Other_Non-neoplastic_Proliferations_of_the_Mouse_Mammary_Gland"                                                                                                       
[21005] "Neoplasms_of_the_Mouse_Mammary_Gland"                                                                                                                                 
[21006] "Benign_Neoplasms_of_the_Mouse_Mammary_Gland"                                                                                                                          
[21007] "Fibroadenoma_of_the_Mouse_Mammary_Gland"                                                                                                                              
[21008] "Papilloma_of_the_Mouse_Mammary_Gland"                                                                                                                                 
[21009] "Adenoma_of_the_Mouse_Mammary_Gland"                                                                                                                                   
[21010] "Adenomyoepithelioma_of_the_Mouse_Mammary_Gland"                                                                                                                       
[21011] "Intraepithelial_Neoplasia_of_the_Mouse_Mammary_Gland"                                                                                                                 
[21012] "Low_Grade_Mouse_MIN"                                                                                                                                                  
[21013] "LobuloAlveolar_Mouse_MIN"                                                                                                                                             
[21014] "Ductal_Mouse_MIN"                                                                                                                                                     
[21015] "Mouse_MIN_NOS"                                                                                                                                                        
[21016] "Simple_Mouse_MIN_NOS"                                                                                                                                                 
[21017] "Cystic_Mouse_MIN_NOS"                                                                                                                                                 
[21018] "Solid_Mouse_MIN_NOS"                                                                                                                                                  
[21019] "Mixed_Mouse_MIN_NOS"                                                                                                                                                  
[21020] "High_Grade_Mouse_MIN"                                                                                                                                                 
[21021] "Carcinoma_in_Situ_of_the_Mouse_Mammary_Gland"                                                                                                                         
[21022] "Malignant_Neoplasms_of_the_Mouse_Mammary_Gland"                                                                                                                       
[21023] "Carcinoma_of_the_Mouse_Mammary_Gland_Histologic_Patterns"                                                                                                             
[21024] "Luminal_Carcinoma_of_the_Mouse_Mammary_Gland"                                                                                                                         
[21025] "Acinar_Mammary_Carcinoma_of_Mouse"                                                                                                                                    
[21026] "Glandular_Mammary_Carcinoma_of_Mouse"                                                                                                                                 
[21027] "Cribriform_Mammary_Carcinoma_of_Mouse"                                                                                                                                
[21028] "Papillary_Mammary_Carcinoma_of_Mouse"                                                                                                                                 
[21029] "Solid_Mammary_Carcinoma_of_Mouse"                                                                                                                                     
[21030] "Other_Mammary_Carcinoma_of_Mouse"                                                                                                                                     
[21031] "Myoepithelial_Carcinoma_of_the_Mouse_Mammary_Gland"                                                                                                                   
[21032] "Myoepithelial_and_Mixed_Glandular_Myoepithelial_Carcinoma_of_the_Mouse_Mammary_Gland"                                                                                 
[21033] "Monomorphic_Myoepithelial_Spindle_Cell_Carcinoma_of_the_Mouse_Mammary_Gland"                                                                                          
[21034] "Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland"                                                                                                                     
[21035] "Adenosquamous_Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland"                                                                                                       
[21036] "Squamous_Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland"                                                                                                            
[21037] "Osseous_Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland"                                                                                                             
[21038] "Spindle_Cell_Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland"                                                                                                        
[21039] "Other_Metaplastic_Carcinomas_of_the_Mouse_Mammary_Gland"                                                                                                              
[21040] "Other_Cancer_of_the_Mouse_Mammary_Gland_NOS"                                                                                                                          
[21041] "Inflammatory_Conditions_of_the_Mouse_Prostate_Gland"                                                                                                                  
[21042] "Mouse_Prostatitis"                                                                                                                                                    
[21043] "Chronic_Active_Prostatitis_of_Mouse"                                                                                                                                  
[21044] "Infectious_Granulomatous_Prostatitis_of_Mouse"                                                                                                                        
[21045] "Abscess_of_the_Mouse_Prostate_Gland"                                                                                                                                  
[21046] "Coagulative_Necrosis_of_the_Mouse_Prostate_Gland"                                                                                                                     
[21047] "Fibrosis_NOS_of_the_Mouse_Prostate_Gland"                                                                                                                             
[21048] "Non-proliferative_Developmental_Conditions_of_the_Mouse_Prostate_Gland"                                                                                               
[21049] "Aplasia_of_the_Mouse_Prostate_Gland"                                                                                                                                  
[21050] "Hypoplasia_of_the_Mouse_Prostate_Gland"                                                                                                                               
[21051] "Non-neoplastic_Proliferation_of_the_Murine_Prostate_Gland"                                                                                                            
[21052] "Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                                                              
[21053] "Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                                                      
[21054] "Physiological_Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                                        
[21055] "Non-physiological_Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                                    
[21056] "Epithelial_Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                                           
[21057] "Stromal_Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                                              
[21058] "Combined_Epithelial_Stromal_Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                          
[21059] "Focal_Hyperplasias_of_the_Mouse_Prostate_Gland"                                                                                                                       
[21060] "Physiological_Focal_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                                          
[21061] "Non-physiological_Focal_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                                      
[21062] "Epithelial_Focal_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                                             
[21063] "Stromal_Focal_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                                                
[21064] "Combined_Epithelial_Stromal_Focal_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                            
[21065] "Other_Non-Neoplastic_Proliferation_of_the_Mouse_Prostate_Gland"                                                                                                       
[21066] "Neoplasms_of_the_Mouse_Prostate_Gland"                                                                                                                                
[21067] "High_Risk_Proliferative_Disease_of_the_Mouse_Prostate_Gland_of_Unknown_or_Premalignant_Potential"                                                                     
[21068] "Atypical_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                                                     
[21069] "Epithelial_Atypical_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                                          
[21070] "Stromal_Atypical_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                                             
[21071] "Combined_Epithelial_Stromal_Atypical_Hyperplasia_of_the_Mouse_Prostate_Gland"                                                                                         
[21072] "Prostatic_Intraepithelial_Neoplasia_of_the_Mouse_Prostate_Gland"                                                                                                      
[21073] "Low_Grade_Mouse_Prostatic_Intraepithelial_Neoplasia"                                                                                                                  
[21074] "High_Grade_Mouse_Prostatic_Intraepithelial_Neoplasia"                                                                                                                 
[21075] "Malignant_Neoplasms_of_the_Mouse_Prostate_Gland"                                                                                                                      
[21076] "Carcinoma_of_the_Mouse_Prostate_Gland"                                                                                                                                
[21077] "Microinvasive_Carcinoma_of_the_Mouse_Prostate_Gland"                                                                                                                  
[21078] "Microinvasive_Adenocarcinoma_of_the_Mouse_Prostate_Gland"                                                                                                             
[21079] "Undifferentiated_Microinvasive_Carcinoma_of_the_Mouse_Prostate_Gland"                                                                                                 
[21080] "Microinvasive_Neuroendocrine_Carcinoma_of_the_Mouse_Prostate_Gland"                                                                                                   
[21081] "Microinvasive_Small_Cell_Carcinoma_of_the_Mouse_Prostate_Gland"                                                                                                       
[21082] "Invasive_Carcinoma_of_the_Mouse_Prostate_Gland"                                                                                                                       
[21083] "Invasive_Adenocarcinoma_of_the_Mouse_Prostate_Gland"                                                                                                                  
[21084] "Moderately_Differentiated_Invasive_Adenocarcinoma_of_the_Mouse_Prostate_Gland"                                                                                        
[21085] "Poorly_Differentiated_Invasive_Adenocarcinoma_of_the_Mouse_Prostate_Gland"                                                                                            
[21086] "Undifferentiated_Invasive_Carcinoma_of_the_Mouse_Prostate_Gland"                                                                                                      
[21087] "Invasive_Neuroendocrine_Carcinoma_of_the_Mouse_Prostate_Gland"                                                                                                        
[21088] "Invasive_Small_Cell_Carcinoma_of_the_Mouse_Prostate_Gland"                                                                                                            
[21089] "Spindle_Cell_Sarcomatoid_Carcinoma_of_the_Mouse_Prostate_Gland"                                                                                                       
[21090] "Squamous_Cell_Carcinoma_of_the_Mouse_Prostate_Gland"                                                                                                                  
[21091] "Adenosquamous_Cell_Carcinoma_of_the_Mouse_Prostate_Gland"                                                                                                             
[21092] "Sarcoma_of_the_Mouse_Prostate_Gland"                                                                                                                                  
[21093] "Leiomyosarcoma_of_the_Mouse_Prostate_Gland"                                                                                                                           
[21094] "Rhabdomyosarcoma_of_the_Mouse_Prostate_Gland"                                                                                                                         
[21095] "Chondrosarcoma_of_the_Mouse_Prostate_Gland"                                                                                                                           
[21096] "Osteosarcoma_of_the_Mouse_Prostate_Gland"                                                                                                                             
[21097] "Sarcoma_NOS_of_the_Mouse_Prostate_Gland"                                                                                                                              
[21098] "Carcinosarcoma_of_the_Mouse_Prostate_Gland"                                                                                                                           
[21099] "Mouse_Primary_Pulmonary_Tumors"                                                                                                                                       
[21100] "Hyperplasia_of_the_Mouse_Pulmonary_System"                                                                                                                            
[21101] "Epithelial_Hyperplasia_of_the_Mouse_Pulmonary_System"                                                                                                                 
[21102] "Neuroendocrine_Hyperplasia_of_the_Mouse_Pulmonary_System"                                                                                                             
[21103] "Epithelial_Tumors_of_the_Murine_Pulmonary_System"                                                                                                                     
[21104] "Benign_Tumors_of_the_Mouse_Pulmonary_System"                                                                                                                          
[21105] "Papilloma_of_the_Mouse_Pulmonary_System"                                                                                                                              
[21106] "Adenoma_of_the_Mouse_Pulmonary_System"                                                                                                                                
[21107] "Papillary_Adenoma_of_the_Mouse_Pulmonary_System"                                                                                                                      
[21108] "Solid_Adenoma_of_the_Mouse_Pulmonary_System"                                                                                                                          
[21109] "Adenoma_of_the_Mouse_Pulmonary_System_with_Mixed_Subtypes"                                                                                                            
[21110] "Preinvasive_Lesions_of_the_Mouse_Pulmonary_System"                                                                                                                    
[21111] "Squamous_Dysplasia_of_the_Mouse_Pulmonary_System"                                                                                                                     
[21112] "Atypical_Adenomatous_Hyperplasia_of_the_Mouse_Pulmonary_System"                                                                                                       
[21113] "Malignant_Tumors_of_the_Mouse_Pulmonary_System"                                                                                                                       
[21114] "Squamous_Cell_Carcinoma_of_the_Mouse_Pulmonary_System"                                                                                                                
[21115] "Adenocarcinoma_of_the_Mouse_Pulmonary_System"                                                                                                                         
[21116] "Papillary_Adenocarcinoma_of_the_Mouse_Pulmonary_System"                                                                                                               
[21117] "Acinar_Adenocarcinoma_of_the_Mouse_Pulmonary_System"                                                                                                                  
[21118] "Solid_Adenocarcinoma_of_the_Mouse_Pulmonary_System"                                                                                                                   
[21119] "Adenocarcinoma_with_Mixed_Subtypes_of_the_Mouse_Pulmonary_System"                                                                                                     
[21120] "Adenocarcinoma_NOS_of_the_Mouse_Pulmonary_System"                                                                                                                     
[21121] "Adenosquamous_Carcinoma_of_the_Mouse_Pulmonary_System"                                                                                                                
[21122] "Neuroendocrine_Carcinoma_of_the_Mouse_Pulmonary_System"                                                                                                               
[21123] "Carcinoma_Other_of_the_Mouse_Pulmonary_System"                                                                                                                        
[21124] "Neoplasms_of_the_Mouse_Skin"                                                                                                                                          
[21125] "Mouse_Melanocytic_Neoplasms_and_Proliferations"                                                                                                                       
[21126] "Melanocytic_Proliferative_Disorders_of_Mouse"                                                                                                                         
[21127] "Junctional_Melanocytic_Hyperplasia_of_Mouse"                                                                                                                          
[21128] "Dermal_Melanocytic_Hyperplasia_of_Mouse"                                                                                                                              
[21129] "Compound_Melanocytic_Hyperplasia_of_Mouse"                                                                                                                            
[21130] "Mouse_Benign_Melanocytic_Neoplasms"                                                                                                                                   
[21131] "Mouse_Melanocytoma"                                                                                                                                                   
[21132] "Mouse_Melanocytic_Neoplasms_of_Uncertain_Malignant_Potential"                                                                                                         
[21133] "Mouse_Malignant_Melanocytic_Neoplasms"                                                                                                                                
[21134] "Mouse_Melanoma"                                                                                                                                                       
[21135] "Mouse_Epithelioid_Melanoma"                                                                                                                                           
[21136] "Mouse_Amelanotic_Epithelioid_Melanoma"                                                                                                                                
[21137] "Mouse_Spindle-cell_Melanoma"                                                                                                                                          
[21138] "Mouse_Amelanotic_Spindle-cell_Melanoma"                                                                                                                               
[21139] "Mouse_Spindle_and_Epithelioid_Melanoma"                                                                                                                               
[21140] "Mouse_Amelanotic_Spindle_and_Epithelioid_Melanoma"                                                                                                                    
[21141] "Other_Mouse_Melanoma"                                                                                                                                                 
[21142] "Squamous_Neoplasms_of_the_Mouse_Skin"                                                                                                                                 
[21143] "Squamous_Proliferative_Disorders_of_the_Mouse_Skin"                                                                                                                   
[21144] "Squamous_Hyperplasia_of_the_Mouse_Skin"                                                                                                                               
[21145] "Squamous_Hyperplasia_of_the_Mouse_Skin_with_Atypia"                                                                                                                   
[21146] "Benign_Squamous_Neoplasms_of_the_Mouse_Skin"                                                                                                                          
[21147] "Papilloma_of_the_Mouse_Skin"                                                                                                                                          
[21148] "Benign_Basal_Cell_Tumor_of_the_Mouse_Skin"                                                                                                                            
[21149] "Squamous_Cell_Carcinoma_in_Situ_of_the_Mouse_Skin"                                                                                                                    
[21150] "Squamous_Cell_Carcinoma_of_the_Mouse_Skin"                                                                                                                            
[21151] "Well-differentiated_Squamous_Cell_Carcinoma_of_the_Mouse_Skin"                                                                                                        
[21152] "Moderately-differentiated_Squamous_Cell_Carcinoma_of_the_Mouse_Skin"                                                                                                  
[21153] "Poorly-differentiated_Squamous_Cell_Carcinoma_of_the_Mouse_Skin"                                                                                                      
[21154] "Spindle-cell_Squamous_Cell_Carcinoma_of_the_Mouse_Skin"                                                                                                               
[21155] "Malignant_Basal_Cell_Tumor_of_the_Mouse_Skin"                                                                                                                         
[21156] "Adnexal_Neoplasms_of_the_Mouse_Skin"                                                                                                                                  
[21157] "Follicular_Neoplasms_of_the_Mouse_Skin"                                                                                                                               
[21158] "Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin"                                                                                                                       
[21159] "Pilomatrixoma_Type_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin"                                                                                                 
[21160] "Trichoblastoma_Type_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin"                                                                                                
[21161] "Trichoepithelioma_Type_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin"                                                                                             
[21162] "Trichofolliculoma_Type_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin"                                                                                             
[21163] "Cylindroma_Type_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin"                                                                                                    
[21164] "Spiradenoma_Type_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin"                                                                                                   
[21165] "Superficial_Basal_Cell_Carcinoma_Type_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin"                                                                              
[21166] "Other_Variants_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin"                                                                                                     
[21167] "Sebaceous_Neoplasms_and_Hyperplasias_of_the_Mouse_Skin"                                                                                                               
[21168] "Sebaceous_Hyperplasia_of_the_Mouse_Skin"                                                                                                                              
[21169] "Sebaceous_Adenoma_of_the_Mouse_Skin"                                                                                                                                  
[21170] "Sebaceous_Carcinoma_of_the_Mouse_Skin"                                                                                                                                
[21171] "Mouse_Eccrine_Neoplasms"                                                                                                                                              
[21172] "Apocrine_Neoplasms_of_the_Mouse_Skin"                                                                                                                                 
[21173] "Mixed_Tumors_of_the_Mouse_Skin"                                                                                                                                       
[21174] "Other_Adnexal_Neoplasms_of_the_Mouse_Skin"                                                                                                                            
[21175] "Benign_Mesenchymal_Neoplasms_of_the_Mouse_Skin"                                                                                                                       
[21176] "Fibroma_of_the_Mouse_Skin"                                                                                                                                            
[21177] "Hemangioma_of_the_Mouse_Skin"                                                                                                                                         
[21178] "Lipoma_of_the_Mouse_Skin"                                                                                                                                             
[21179] "Hibernoma_of_the_Mouse_Skin"                                                                                                                                          
[21180] "Schwannoma_of_the_Mouse_Skin"                                                                                                                                         
[21181] "Neurofibroma_of_the_Mouse_Skin"                                                                                                                                       
[21182] "Myxoma_of_the_Mouse_Skin"                                                                                                                                             
[21183] "Granular_Cell_Tumor_of_the_Mouse_Skin"                                                                                                                                
[21184] "Sarcomas_of_the_Mouse_Skin_and_Subcutis"                                                                                                                              
[21185] "Hemangiosarcoma_of_the_Mouse_Skin"                                                                                                                                    
[21186] "Lymphangiosarcoma_of_the_Mouse_Skin"                                                                                                                                  
[21187] "Malignant_Peripheral_Nerve_Sheath_Tumor_of_the_Mouse_Skin"                                                                                                            
[21188] "Leiomyosarcoma_of_the_Mouse_Skin"                                                                                                                                     
[21189] "Rhabdomyosarcoma_of_the_Mouse_Skin"                                                                                                                                   
[21190] "Liposarcoma_of_the_Mouse_Skin"                                                                                                                                        
[21191] "Unclassified_Malignant_Spindle_Cell_Neoplasm_of_the_Mouse_Skin"                                                                                                       
[21192] "Mouse_Cutaneous_Tumors_of_Hematompoetic_Origin"                                                                                                                       
[21193] "Mouse_Cutaneous_Lymphomas"                                                                                                                                            
[21194] "B-cell_Lymphomas_of_the_Mouse_Skin"                                                                                                                                   
[21195] "T-cell_Lymphomas_of_the_Mouse_Skin"                                                                                                                                   
[21196] "Other_Lymphomas_of_the_Mouse_Skin"                                                                                                                                    
[21197] "Plasma_Cell_Neoplasms_of_the_Mouse_Skin"                                                                                                                              
[21198] "Benign_Plasma_Cell_Proliferations_of_the_Mouse_Skin"                                                                                                                  
[21199] "Malignant_Plasmacytoma_of_the_Mouse_Skin"                                                                                                                             
[21200] "Histiocytic_Neoplasms_of_the_Mouse_Skin"                                                                                                                              
[21201] "Benign_Histiocytic_Neoplasms_of_the_Mouse_Skin"                                                                                                                       
[21202] "Malignant_Histiocytic_Neoplasms_of_the_Mouse_Skin"                                                                                                                    
[21203] "Mast_Cell_Neoplasms_of_the_Mouse_Skin"                                                                                                                                
[21204] "Mastocytoma_of_the_Mouse_Skin"                                                                                                                                        
[21205] "Other_Cutaneous_Neoplasms_of_Hematopoetic_Origin_of_Mouse"                                                                                                            
[21206] "Non-neoplastic_Disorders_of_the_Mouse_Skin"                                                                                                                           
[21207] "Disorders_of_the_Squamous_Epithelium_of_the_Mouse_Skin"                                                                                                               
[21208] "Disorders_of_Pigmentation_of_the_Mouse_Skin"                                                                                                                          
[21209] "Disorders_of_the_Mouse_Hair_Follicle"                                                                                                                                 
[21210] "Follicular_Cyst_of_the_Mouse_Skin"                                                                                                                                    
[21211] "Non-Neoplastic_Hematopoietic_Disorders_of_Mouse"                                                                                                                      
[21212] "Non-Neoplastic_Non-Lymphoid_Hematopoietic_Disorders_of_Mouse"                                                                                                         
[21213] "Non-Neoplastic_Myeloid_Disorders_of_Mouse"                                                                                                                            
[21214] "Non-Neoplastic_Splenic_Myeloid_Hyperplasia_of_Mouse"                                                                                                                  
[21215] "Mouse_Extramedullary_Hematopoiesis"                                                                                                                                   
[21216] "Non-Neoplastic_Histiocytic_Disorders_of_Mouse"                                                                                                                        
[21217] "Sinus_Histiocytosis_of_Mouse"                                                                                                                                         
[21218] "Histiocytosis_in_Association_with_a_Hematopoietic_Neoplasm_of_Mouse"                                                                                                  
[21219] "Non-Neoplastic_Mast_Cell_Disorders_of_the_Mouse_Hematologic_System"                                                                                                   
[21220] "Mastocytosis_of_the_Mouse_Hematologic_System"                                                                                                                         
[21221] "Non-neoplastic_Lymphoid_Disorders_of_the_Mouse_Hematologic_System"                                                                                                    
[21222] "Pre-lymphoma_Lymphoproliferative_Disorders_of_the_Mouse_Hematologic_System"                                                                                           
[21223] "Fas_and_Fas_Ligand_Diseases_of_the_Mouse_Hematologic_System"                                                                                                          
[21224] "SJL_Disease_of_the_Mouse_Hematologic_System"                                                                                                                          
[21225] "MAIDS"                                                                                                                                                                
[21226] "Mouse_Hematologic_Neoplasms_and_Related_Disorders"                                                                                                                    
[21227] "Non-Lymphoid_Hematopoietic_Neoplasm_of_Mouse"                                                                                                                         
[21228] "Mouse_Non-lymphoid_Hematopoietic_Sarcoma"                                                                                                                             
[21229] "Mouse_Granulocytic_Hematopoietic_Sarcoma"                                                                                                                             
[21230] "Mouse_Histiocytic_Hematopoietic_Sarcoma"                                                                                                                              
[21231] "Mouse_Mast_Cell_Hematopoietic_Sarcoma"                                                                                                                                
[21232] "Mouse_Non-lymphoid_Leukemia"                                                                                                                                          
[21233] "Mouse_Myeloid_Leukemia"                                                                                                                                               
[21234] "Mouse_Myeloid_Leukemia_without_Maturation"                                                                                                                            
[21235] "Mouse_Myeloid_Leukemia_with_Maturation"                                                                                                                               
[21236] "Mouse_MPD-like_Myeloid_Leukemia"                                                                                                                                      
[21237] "Mouse_Myelomonocytic_Leukemia"                                                                                                                                        
[21238] "Mouse_Monocytic_Leukemia"                                                                                                                                             
[21239] "Mouse_Erythroid_Leukemia"                                                                                                                                             
[21240] "Mouse_Megakaryocytic_Leukemia"                                                                                                                                        
[21241] "Mouse_Bi-phenotypic_Leukemia"                                                                                                                                         
[21242] "Myeloid_Dysplasia_of_Mouse"                                                                                                                                           
[21243] "Mouse_Myelodysplastic_Syndrome"                                                                                                                                       
[21244] "Cytopenia_with_Increased_Blasts_of_Mouse"                                                                                                                             
[21245] "Mouse_Myeloid_Proliferation"                                                                                                                                          
[21246] "Mouse_Myeloproliferation"                                                                                                                                             
[21247] "Mouse_Myeloproliferative_Disease"                                                                                                                                     
[21248] "Lymphoid_Neoplasms_and_Related_Disorders_of_the_Mouse_Hematologic_System"                                                                                             
[21249] "B_Cell_Neoplasms_of_the_Mouse_Hematologic_System"                                                                                                                     
[21250] "Precursor_B_Cell_Neoplasm_of_the_Mouse_Hematologic_System"                                                                                                            
[21251] "Mouse_Precursor_B_Cell_Lymphoblastic_Lymphoma_Leukemia"                                                                                                               
[21252] "Mature_B_Cell_Neoplasms_of_the_Mouse_Hematologic_System"                                                                                                              
[21253] "Small_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System"                                                                                                                
[21254] "Splenic_Marginal_Zone_Lymphoma_of_the_Mouse_Hematologic_System"                                                                                                       
[21255] "Follicular_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System"                                                                                                           
[21256] "Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System"                                                                                                        
[21257] "Centroblastic_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System"                                                                                          
[21258] "Immunoblastic_Diffuse_Large_B_Cell_LymphomaLymphoblastic_Lymphoma_Type_of_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System"                              
[21259] "Histiocyte-Associated_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System"                                                                                  
[21260] "Primary_Mediastinal_Thymic_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System"                                                                             
[21261] "Classic_Burkitt_Lymphoma_of_the_Mouse_Hematologic_System"                                                                                                             
[21262] "Plasma_Cell_Neoplasm_of_the_Mouse_Hematologic_System"                                                                                                                 
[21263] "Plasmacytoma_of_the_Mouse_Hematologic_System"                                                                                                                         
[21264] "Extraosseus_Plasmacytoma_of_the_Mouse_Hematologic_System"                                                                                                             
[21265] "Anaplastic_Plasmacytoma_of_the_Mouse_Hematologic_System"                                                                                                              
[21266] "B-NK_Cell_Lymphoma_of_the_Mouse_Hematologic_System"                                                                                                                   
[21267] "T_Cell_Neoplasms_of_the_Mouse_Hematologic_System"                                                                                                                     
[21268] "Precursor_T_Cell_Neoplasm_of_the_Mouse_Hematologic_System"                                                                                                            
[21269] "Mouse_Precursor_T_Cell_Lymphoblastic_Lymphoma_Leukemia"                                                                                                               
[21270] "Large_Cell_Anaplastic_Lymphoma_of_the_Mouse_Hematologic_System"                                                                                                       
[21271] "Mature_T_Cell_Lineage_Lymphoma_of_the_Mouse_Hematologic_System"                                                                                                       
[21272] "Small_T_Cell_Lymphoma_of_the_Mouse_Hematologic_System"                                                                                                                
[21273] "Mouse_T-NK_Cell_Lymphoma"                                                                                                                                             
[21274] "Mouse_Nervous_System_Neoplasms"                                                                                                                                       
[21275] "Mouse_Tumors_of_Neuroepithelial_Tissue"                                                                                                                               
[21276] "Mouse_Astrocytic_Tumours"                                                                                                                                             
[21277] "Mouse_Diffuse_Astrocytoma"                                                                                                                                            
[21278] "Mouse_Fibrillary_Astrocytoma"                                                                                                                                         
[21279] "Mouse_Protoplasmic_Astrocytoma"                                                                                                                                       
[21280] "Mouse_Gemistocytic_Astrocytoma"                                                                                                                                       
[21281] "Mouse_Anaplastic_Astrocytoma"                                                                                                                                         
[21282] "Mouse_Glioblastoma"                                                                                                                                                   
[21283] "Mouse_Giant_Cell_Glioblastoma"                                                                                                                                        
[21284] "Mouse_Gliosarcoma"                                                                                                                                                    
[21285] "Mouse_Pilocytic_Astrocytoma"                                                                                                                                          
[21286] "Mouse_Pleomorphic_Xanthoastrocytoma"                                                                                                                                  
[21287] "Mouse_Subependymal_Giant_Cell_Astrocytoma"                                                                                                                            
[21288] "Mouse_Oligodendroglial_Tumours"                                                                                                                                       
[21289] "Mouse_Oligodendroglioma"                                                                                                                                              
[21290] "Mouse_Anaplastic_Oligodendroglioma"                                                                                                                                   
[21291] "Mixed_Mouse_Gliomas"                                                                                                                                                  
[21292] "Mouse_Oligoastrocytoma"                                                                                                                                               
[21293] "Mouse_Anaplastic_Oligoastrocytoma"                                                                                                                                    
[21294] "Mouse_Ependymal_Tumours"                                                                                                                                              
[21295] "Mouse_Ependymoma"                                                                                                                                                     
[21296] "Mouse_Cellular_Ependymoma"                                                                                                                                            
[21297] "Mouse_Papillary_Ependymoma"                                                                                                                                           
[21298] "Mouse_Clear_Cell_Ependymoma"                                                                                                                                          
[21299] "Mouse_Tanycytic_Ependymoma"                                                                                                                                           
[21300] "Mouse_Anaplastic_Ependymoma"                                                                                                                                          
[21301] "Mouse_Myxopapillary_Ependymoma"                                                                                                                                       
[21302] "Mouse_Subependymoma"                                                                                                                                                  
[21303] "Mouse_Choroid_Plexus_Tumours"                                                                                                                                         
[21304] "Mouse_Choroid_Plexus_Papilloma"                                                                                                                                       
[21305] "Mouse_Choroid_Plexus_Carcinoma"                                                                                                                                       
[21306] "Mouse_Glial_Tumours_of_Uncertain_Origin"                                                                                                                              
[21307] "Mouse_Astroblastoma"                                                                                                                                                  
[21308] "Mouse_Gliomatosis_Cerebri"                                                                                                                                            
[21309] "Mouse_Chordoid_Glioma_of_the_3rd_Ventricle"                                                                                                                           
[21310] "Mouse_Neuronal_and_Mixed_Neuronal-glial_Tumours"                                                                                                                      
[21311] "Mouse_Gangliocytoma"                                                                                                                                                  
[21312] "Dysplastic_Lhermitte-Duclos_Gangliocytoma_of_Mouse_Cerebellum"                                                                                                        
[21313] "Mouse_Desmoplastic_Infantile_Astrocytoma_Ganglioglioma"                                                                                                               
[21314] "Mouse_Dysembryoplastic_Neuroepithelial_Tumour"                                                                                                                        
[21315] "Mouse_Ganglioglioma"                                                                                                                                                  
[21316] "Mouse_Anaplastic_Ganglioglioma"                                                                                                                                       
[21317] "Mouse_Central_Neurocytoma"                                                                                                                                            
[21318] "Mouse_Cerebellar_Liponeurocytoma"                                                                                                                                     
[21319] "Paraganglioma_of_the_Mouse_Filum_Terminale"                                                                                                                           
[21320] "Mouse_Neuroblastic_Tumours"                                                                                                                                           
[21321] "Mouse_Olfactory_Neuroblastoma"                                                                                                                                        
[21322] "Mouse_Olfactory_Neuroepithelioma"                                                                                                                                     
[21323] "Neuroblastomas_of_the_Mouse_Adrenal_Gland_and_Sympathetic_Nervous_System"                                                                                             
[21324] "Mouse_Pineal_Parenchymal_Tumours"                                                                                                                                     
[21325] "Mouse_Pineocytoma"                                                                                                                                                    
[21326] "Mouse_Pineoblastoma"                                                                                                                                                  
[21327] "Mouse_Pineal_Parenchymal_Tumour_of_Intermediate_Differentiation"                                                                                                      
[21328] "Mouse_Embryonal_Tumours"                                                                                                                                              
[21329] "Mouse_Medulloepithelioma"                                                                                                                                             
[21330] "Mouse_Ependymoblastoma"                                                                                                                                               
[21331] "Mouse_Medulloblastoma"                                                                                                                                                
[21332] "Mouse_Desmoplastic_Medulloblastoma"                                                                                                                                   
[21333] "Mouse_Large_Cell_Medulloblastoma"                                                                                                                                     
[21334] "Mouse_Medullomyoblastoma"                                                                                                                                             
[21335] "Mouse_Melanotic_Medulloblastoma"                                                                                                                                      
[21336] "Mouse_Supratentorial_Primitive_Neuroectodermal_Tumour"                                                                                                                
[21337] "Mouse_Neuroblastoma"                                                                                                                                                  
[21338] "Mouse_Ganglioneuroblastoma"                                                                                                                                           
[21339] "Atypical_Mouse_Tertoid_Thaboid_Tumour"                                                                                                                                
[21340] "Tumors_of_the_Mouse_Peripheral_Nerves"                                                                                                                                
[21341] "Mouse_Schwannoma"                                                                                                                                                     
[21342] "Mouse_Cellular_Neurilemmoma_Neurinoma"                                                                                                                                
[21343] "Mouse_Plexiform_Neurilemmoma_Neurinoma"                                                                                                                               
[21344] "Mouse_Melanotic_Neurilemmoma_Neurinoma"                                                                                                                               
[21345] "Mouse_Neurofibroma"                                                                                                                                                   
[21346] "Mouse_Plexiform_Neurofibroma"                                                                                                                                         
[21347] "Mouse_Perineurioma"                                                                                                                                                   
[21348] "Mouse_Intraneural_Perineurioma"                                                                                                                                       
[21349] "Mouse_Soft_Tissue_Perineurioma"                                                                                                                                       
[21350] "Malignant_Mouse_Peripheral_Nerve_Sheath_Tumor"                                                                                                                        
[21351] "Mouse_Epithelioid_MPNST"                                                                                                                                              
[21352] "Mouse_MPNST_with_Divergent_Mesenchymal_and_or_Epithelial_Differentiation"                                                                                             
[21353] "Mouse_Melanotic_MPNST"                                                                                                                                                
[21354] "Mouse_Melanotic_Psammomatous_MPNST"                                                                                                                                   
[21355] "Tumors_of_the_Mouse_Meninges"                                                                                                                                         
[21356] "Tumors_of_the_Mouse_Meningothelial_Cells"                                                                                                                             
[21357] "Mouse_Meningioma"                                                                                                                                                     
[21358] "Mouse_Meningothelial_Meningioma"                                                                                                                                      
[21359] "Mouse_Fibrous_Fibroblastic_Meningioma"                                                                                                                                
[21360] "Mouse_Transitional_Mixed_Meningioma"                                                                                                                                  
[21361] "Mouse_Psammomatous_Meningioma"                                                                                                                                        
[21362] "Mouse_Angiomatous_Meningioma"                                                                                                                                         
[21363] "Mouse_Microcystic_Meningioma"                                                                                                                                         
[21364] "Mouse_Secretory_Meningioma"                                                                                                                                           
[21365] "Mouse_Lymphoplasmacyte-rich_Meningioma"                                                                                                                               
[21366] "Mouse_Metaplastic_Meningioma"                                                                                                                                         
[21367] "Mouse_Clear_Cell_Meningioma"                                                                                                                                          
[21368] "Mouse_Chordoid_Meningioma"                                                                                                                                            
[21369] "Atypical_Mouse_Meningioma"                                                                                                                                            
[21370] "Mouse_Papillary_Meningioma"                                                                                                                                           
[21371] "Mouse_Rhabdoid_Meningioma"                                                                                                                                            
[21372] "Mouse_Anaplastic_Meningioma"                                                                                                                                          
[21373] "Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System"                                                                                                   
[21374] "Lipoma_of_the_Mouse_Nervous_System"                                                                                                                                   
[21375] "Angiolipoma_of_the_Mouse_Nervous_System"                                                                                                                              
[21376] "Hibernoma_of_the_Mouse_Nervous_System"                                                                                                                                
[21377] "Intracranial_Liposarcoma_of_the_Mouse_Nervous_System"                                                                                                                 
[21378] "Solitary_Fibrous_Tumour_of_the_Mouse_Nervous_System"                                                                                                                  
[21379] "Fibrosarcoma_of_the_Mouse_Nervous_System"                                                                                                                             
[21380] "Malignant_Fibrous_Histiocytoma_of_the_Mouse_Nervous_System"                                                                                                           
[21381] "Leiomyoma_of_the_Mouse_Nervous_System"                                                                                                                                
[21382] "Leiomyosarcoma_of_the_Mouse_Nervous_System"                                                                                                                           
[21383] "Rhabdomyoma_of_the_Mouse_Nervous_System"                                                                                                                              
[21384] "Rhabdomyosarcoma_of_the_Mouse_Nervous_System"                                                                                                                         
[21385] "Chondroma_of_the_Mouse_Nervous_System"                                                                                                                                
[21386] "Chondrosarcoma_of_the_Mouse_Nervous_System"                                                                                                                           
[21387] "Osteoma_of_the_Mouse_Nervous_System"                                                                                                                                  
[21388] "Osteosarcoma_of_the_Mouse_Nervous_System"                                                                                                                             
[21389] "Osteochondroma_of_the_Mouse_Nervous_System"                                                                                                                           
[21390] "Haemangioma_of_the_Mouse_Nervous_System"                                                                                                                              
[21391] "Epithelioid_Haemangioendothelioma_of_the_Mouse_Nervous_System"                                                                                                        
[21392] "Haemangiopericytoma_of_the_Mouse_Nervous_System"                                                                                                                      
[21393] "Angiosarcoma_of_the_Mouse_Nervous_System"                                                                                                                             
[21394] "Kaposi_Sarcoma_of_the_Mouse_Nervous_System"                                                                                                                           
[21395] "Primary_Melanocytic_Lesions_of_the_Mouse_Nervous_System"                                                                                                              
[21396] "Diffuse_Melanocytosis_of_the_Mouse_Nervous_System"                                                                                                                    
[21397] "Melanocytoma_of_the_Mouse_Nervous_System"                                                                                                                             
[21398] "Malignant_Melanoma_of_the_Mouse_Nervous_System"                                                                                                                       
[21399] "Mouse_Meningeal_Melanomatosis"                                                                                                                                        
[21400] "Mouse_Nervous_System_Tumors_of_Uncertain_Histogenesis"                                                                                                                
[21401] "Mouse_Hemangioblastoma"                                                                                                                                               
[21402] "Lymphomas_and_Haemopoietic_Neoplasms_of_the_Mouse_Nervous_System"                                                                                                     
[21403] "Malignant_Lymphomas_of_the_Mouse_Nervous_System"                                                                                                                      
[21404] "Plasmacytoma_of_the_Mouse_Nervous_System"                                                                                                                             
[21405] "Granulocytic_Sarcoma_of_the_Mouse_Nervous_System"                                                                                                                     
[21406] "Germ_Cell_Tumors_of_the_Mouse_Nervous_System"                                                                                                                         
[21407] "Germinoma_of_the_Mouse_Nervous_System"                                                                                                                                
[21408] "Embryonal_Carcinoma_of_the_Mouse_Nervous_System"                                                                                                                      
[21409] "Yolk_Sac_Tumour_of_the_Mouse_Nervous_System"                                                                                                                          
[21410] "Choriocarcinoma_of_the_Mouse_Nervous_System"                                                                                                                          
[21411] "Teratoma_of_the_Mouse_Nervous_System"                                                                                                                                 
[21412] "Mature_Teratoma_of_the_Mouse_Nervous_System"                                                                                                                          
[21413] "Immature_Teratoma_of_the_Mouse_Nervous_System"                                                                                                                        
[21414] "Teratoma_of_the_Mouse_Nervous_System_with_Malignant_Transformation"                                                                                                   
[21415] "Mixed_Germ_Cell_Tumours_of_the_Mouse_Nervous_System"                                                                                                                  
[21416] "Tumors_of_the_Mouse_Sellar_Region"                                                                                                                                    
[21417] "Mouse_Craniopharyngioma"                                                                                                                                              
[21418] "Mouse_Adamantinomatous_Craniopharyngioma"                                                                                                                             
[21419] "Mouse_Papillary_Craniopharyngioma"                                                                                                                                    
[21420] "Granular_Cell_Tumor_of_the_Mouse_Sellar_Region"                                                                                                                       
[21421] "Metastatic_Tumours_of_the_Mouse_Nervous_System"                                                                                                                       
[21422] "Inflammatory_Diseases_of_the_Mouse_Intestinal_Tract"                                                                                                                  
[21423] "Acute_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                                        
[21424] "Focal_Acute_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                                  
[21425] "Focal_Acute_Suppurative_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                      
[21426] "Focal_Acute_Eosinophilic_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                     
[21427] "Diffuse_Acute_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                                
[21428] "Diffuse_Acute_Suppurative_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                    
[21429] "Diffuse_Acute_Eosinophilic_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                   
[21430] "Acute_Ulcerative_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                             
[21431] "Chronic_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                                      
[21432] "Focal_Chronic_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                                
[21433] "Focal_Chronic_Granulomatous_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                  
[21434] "Focal_Chronic_Lymphoplasmacytic_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                              
[21435] "Diffuse_Chronic_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                              
[21436] "Diffuse_Chronic_Granulomatous_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                
[21437] "Diffuse_Chronic_Lymphoplasmacytic_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                            
[21438] "Chronic_Ulcerative_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                           
[21439] "Necrotizing_Enteritis_of_the_Mouse_Intestinal_Tract"                                                                                                                  
[21440] "Hyperplasia_of_the_Mouse_Intestinal_Tract"                                                                                                                            
[21441] "Mucosal_Hyperplasia_of_the_Mouse_Intestinal_Tract"                                                                                                                    
[21442] "Focal_Mucosal_Hyperplasia_of_the_Mouse_Intestinal_Tract"                                                                                                              
[21443] "Diffuse_Mucosal_Hyperplasia_of_the_Mouse_Intestinal_Tract"                                                                                                            
[21444] "Lymphoid_Hyperplasia_of_the_Mouse_Intestinal_Tract"                                                                                                                   
[21445] "Neuroendocrine_Cell_Hyperplasia_of_the_Mouse_Intestinal_Tract"                                                                                                        
[21446] "Benign_Conditions_of_the_Mouse_Intestinal_Tract"                                                                                                                      
[21447] "Mucosal_Herniation_of_the_Mouse_Intestinal_Tract"                                                                                                                     
[21448] "Hamartoma_of_the_Mouse_Intestinal_Tract"                                                                                                                              
[21449] "Congestion_of_the_Mouse_Intestinal_Tract"                                                                                                                             
[21450] "Focal_Congestion_of_the_Mouse_Intestinal_Tract"                                                                                                                       
[21451] "Diffuse_Congestion_of_the_Mouse_Intestinal_Tract"                                                                                                                     
[21452] "Squamous_Metaplasia_of_the_Mouse_Intestinal_Tract"                                                                                                                    
[21453] "Erosion_of_the_Mouse_Intestinal_Tract"                                                                                                                                
[21454] "Mucosal_Atrophy_of_the_Mouse_Intestinal_Tract"                                                                                                                        
[21455] "Ulceration_of_the_Mouse_Intestinal_Tract"                                                                                                                             
[21456] "Glandular_Cystic_Dilation_of_the_Mouse_Intestinal_Tract"                                                                                                              
[21457] "Preneoplastic_Lesions_of_the_Mouse_Intestinal_Tract"                                                                                                                  
[21458] "Aberrant_Crypt_Foci_of_the_Mouse_Intestinal_Tract"                                                                                                                    
[21459] "Neoplasms_of_the_Mouse_Intestinal_Tract"                                                                                                                              
[21460] "Gastrointestinal_Intraepithelial_Neoplasia_of_Mouse"                                                                                                                  
[21461] "Benign_Neoplasms_of_the_Mouse_Intestinal_Tract"                                                                                                                       
[21462] "Adenoma_of_the_Mouse_Intestinal_Tract"                                                                                                                                
[21463] "Sessile_Adenoma_of_the_Mouse_Intestinal_Tract"                                                                                                                        
[21464] "Sessile_Tubular_Adenoma_of_the_Mouse_Intestinal_Tract"                                                                                                                
[21465] "Low_Grade_Sessile_Tubular_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                                    
[21466] "High_Grade_Sessile_Tubular_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                                   
[21467] "Sessile_Villous_Adenoma_of_the_Mouse_Intestinal_Tract"                                                                                                                
[21468] "Low_Grade_Sessile_Villous_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                                    
[21469] "High_Grade_Sessile_Villous_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                                   
[21470] "Sessile_Tubulovillous_Adenoma_of_the_Mouse_Intestinal_Tract"                                                                                                          
[21471] "Low_Grade_Sessile_Tubulovillous_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                              
[21472] "High_Grade_Sessile_Tubulovillous_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                             
[21473] "Flat_Adenoma_of_the_Mouse_Intestinal_Tract"                                                                                                                           
[21474] "Flat_Tubular_Adenoma_of_the_Mouse_Intestinal_Tract"                                                                                                                   
[21475] "Low_Grade_Flat_Tubular_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                                       
[21476] "High_Grade_Flat_Tubular_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                                      
[21477] "Flat_Villous_Adenoma_of_the_Mouse_Intestinal_Tract"                                                                                                                   
[21478] "Low_Grade_Flat_Villous_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                                       
[21479] "High_Grade_Flat_Villous_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                                      
[21480] "Flat_Tubulovillous_Adenoma_of_the_Mouse_Intestinal_Tract"                                                                                                             
[21481] "Low_Grade_Flat_Tubulovillous_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                                 
[21482] "High_Grade_Flat_Tubulovillous_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                                
[21483] "Pedunculated_Adenoma_of_the_Mouse_Intestinal_Tract"                                                                                                                   
[21484] "Pedunculated_Tubular_Adenoma_of_the_Mouse_Intestinal_Tract"                                                                                                           
[21485] "Low_Grade_Pedunculated_Tubular_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                               
[21486] "High_Grade_Pedunculated_Tubular_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                              
[21487] "Pedunculated_Tubulovillous_Adenoma_of_the_Mouse_Intestinal_Tract"                                                                                                     
[21488] "Low_Grade_Pedunculated_Tubulovillous_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                         
[21489] "High_Grade_Pedunculated_Tubulovillous_Dysplasia_of_the_Mouse_Intestinal_Tract"                                                                                        
[21490] "Fibroma_of_the_Mouse_Intestinal_Tract"                                                                                                                                
[21491] "Leiomyoma_of_the_Mouse_Intestinal_Tract"                                                                                                                              
[21492] "Lipoma_of_the_Mouse_Intestinal_Tract"                                                                                                                                 
[21493] "Hemangioma_of_the_Mouse_Intestinal_Tract"                                                                                                                             
[21494] "Neuroendocrine_Adenoma_of_the_Mouse_Intestinal_Tract"                                                                                                                 
[21495] "Malignant_Neoplasms_of_the_Mouse_Intestinal_Tract"                                                                                                                    
[21496] "Adenocarcinoma_of_the_Mouse_Intestinal_Tract"                                                                                                                         
[21497] "Tubular_Adenocarcinoma_of_the_Mouse_Intestinal_Tract"                                                                                                                 
[21498] "Mucinous_Adenocarcinoma_of_the_Mouse_Intestinal_Tract"                                                                                                                
[21499] "Villous_Adenocarcinoma_of_the_Mouse_Intestinal_Tract"                                                                                                                 
[21500] "Signet_Ring_Cell_Adenocarcinoma_of_the_Mouse_Intestinal_Tract"                                                                                                        
[21501] "Squamous_Cell_Carcinoma_of_the_Mouse_Intestinal_Tract"                                                                                                                
[21502] "Fibrosarcoma_of_the_Mouse_Intestinal_Tract"                                                                                                                           
[21503] "Leiomyosarcoma_of_the_Mouse_Intestinal_Tract"                                                                                                                         
[21504] "Lymphoma_of_the_Mouse_Intestinal_Tract"                                                                                                                               
[21505] "Hemangiosarcoma_of_the_Mouse_Intestinal_Tract"                                                                                                                        
[21506] "Liposarcoma_of_the_Mouse_Intestinal_Tract"                                                                                                                            
[21507] "Neuroendocrine_Cell_Carcinoma_of_the_Mouse_Intestinal_Tract"                                                                                                          
[21508] "Murine_Tissue_Type"                                                                                                                                                   
[21509] "Male_Reproductive_System_MMHCC"                                                                                                                                       
[21510] "Prostate_Gland_MMHCC"                                                                                                                                                 
[21511] "Ampullary_Gland_MMHCC"                                                                                                                                                
[21512] "Bulbourethral_Gland_MMHCC"                                                                                                                                            
[21513] "Anterior_Prostate_Gland_MMHCC"                                                                                                                                        
[21514] "Epididymis_MMHCC"                                                                                                                                                     
[21515] "Epididymis_Interstitial_Cell_MMHCC"                                                                                                                                   
[21516] "Penis_MMHCC"                                                                                                                                                          
[21517] "Prepuce_MMHCC"                                                                                                                                                        
[21518] "Prepucial_Gland_MMHCC"                                                                                                                                                
[21519] "Rete_Testis_MMHCC"                                                                                                                                                    
[21520] "Scrotum_MMHCC"                                                                                                                                                        
[21521] "Seminal_Vesicles_MMHCC"                                                                                                                                               
[21522] "Testis_MMHCC"                                                                                                                                                         
[21523] "Testis_Germ_Cell_MMHCC"                                                                                                                                               
[21524] "Testis_Interstitial_Cell_MMHCC"                                                                                                                                       
[21525] "Testis_Leydig_Cell_MMHCC"                                                                                                                                             
[21526] "Testis_Seminiferous_Tubules_MMHCC"                                                                                                                                    
[21527] "Sertoli_Cells_MMHCC"                                                                                                                                                  
[21528] "Tunica_Vaginalis_Testis_MMHCC"                                                                                                                                        
[21529] "Vas_Deferens_MMHCC"                                                                                                                                                   
[21530] "Vesicular_Gland_MMHCC"                                                                                                                                                
[21531] "Experimental_Organism_Diagnoses"                                                                                                                                      
[21532] "Experimental_Organism_Anatomical_Concepts"                                                                                                                            
[21533] "Genetically_Engineered_Mouse"                                                                                                                                         
[21534] "Transgene"                                                                                                                                                            
[21535] "Mouse_Prostate"                                                                                                                                                       
[21536] "Ventral_Prostate"                                                                                                                                                     
[21537] "Right_Dorsolateral_Prostate"                                                                                                                                          
[21538] "Right_Coagulating_Gland"                                                                                                                                              
[21539] "Capsule_of_Ventral_Lobe_of_Prostate"                                                                                                                                  
[21540] "Parenchyma_of_Right_Lobe_of_Ventral_Prostate"                                                                                                                         
[21541] "Stroma_of_Right_Lobe_of_Ventral_Prostate"                                                                                                                             
[21542] "Capsule_of_Right_Coagulating_Gland_of_Prostate"                                                                                                                       
[21543] "Parenchyma_of_Right_Coagulating_Gland_of_Prostate"                                                                                                                    
[21544] "Stroma_of_Right_Coagulating_Gland_of_Prostate"                                                                                                                        
[21545] "Wall_of_Duct_Proper_of_Left_Coagulating_Gland"                                                                                                                        
[21546] "Left_Coagulating_Gland"                                                                                                                                               
[21547] "Right_Lobe_of_Ventral_Prostate"                                                                                                                                       
[21548] "Left_Lobe_of_Ventral_Prostate"                                                                                                                                        
[21549] "Parenchyma_of_Left_Lobe_of_Ventral_Prostate"                                                                                                                          
[21550] "Stroma_of_Left_Lobe_of_Ventral_Prostate"                                                                                                                              
[21551] "Duct_Tree_of_Right_Lobe_of_Ventral_Prostate"                                                                                                                          
[21552] "Duct_Tree_of_Left_Lobe_of_Ventral_Prostate"                                                                                                                           
[21553] "Periductal_Adventitia_of_Right_Lobe_of_Ventral_Prostate"                                                                                                              
[21554] "Periductal_Adventitia_of_Left_Lobe_of_Ventral_Prostate"                                                                                                               
[21555] "Interductal_Stroma_of_Right_Lobe_of_Ventral_Prostate"                                                                                                                 
[21556] "Interductal_Stroma_of_Left_Lobe_of_Ventral_Prostate"                                                                                                                  
[21557] "Primary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                                                       
[21558] "Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                                                     
[21559] "Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                                                      
[21560] "Primary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                                                        
[21561] "Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                                                      
[21562] "Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                                                       
[21563] "Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                                      
[21564] "Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate"                                                                                                                
[21565] "Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate"                                                                                                                 
[21566] "Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                                       
[21567] "Left_Dorsolateral_Prostate"                                                                                                                                           
[21568] "Capsule_of_Right_Dorsolateral_Prostate"                                                                                                                               
[21569] "Capsule_of_Left_Dorsolateral_Prostate"                                                                                                                                
[21570] "Parenchyma_of_Right_Dorsolateral_Prostate"                                                                                                                            
[21571] "Stroma_of_Right_Dorsolateral_Prostate"                                                                                                                                
[21572] "Stroma_of_Left_Dorsolateral_Prostate"                                                                                                                                 
[21573] "Parenchyma_of_Left_Dorsolateral_Prostate"                                                                                                                             
[21574] "Right_Coagulating_Gland_Proper"                                                                                                                                       
[21575] "Left_Coagulating_Gland_Proper"                                                                                                                                        
[21576] "Duct_of_Right_Coagulating_Gland"                                                                                                                                      
[21577] "Duct_of_Left_Coagulating_Gland"                                                                                                                                       
[21578] "Duct_Tree_of_Right_Dorsolateral_Prostate"                                                                                                                             
[21579] "Duct_Tree_of_Left_Dorsolateral_Prostate"                                                                                                                              
[21580] "Periductal_Adventitia_of_Right_Dorsolateral_Prostate"                                                                                                                 
[21581] "Periductal_Adventitia_of_Left_Dorsolateral_Prostate"                                                                                                                  
[21582] "Interductal_Stroma_of_Right_Dorsolateral_Prostate"                                                                                                                    
[21583] "Interductal_Stroma_of_Left_Dorsolateral_Prostate"                                                                                                                     
[21584] "Primary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                                          
[21585] "Secondary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                                        
[21586] "Tertiary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                                         
[21587] "Primary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                                           
[21588] "Secondary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                                         
[21589] "Tertiary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                                          
[21590] "Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                         
[21591] "Primary_Duct_Proper_of_Right_Dorsolateral_Prostate"                                                                                                                   
[21592] "Primary_Duct_Proper_of_Left_Dorsolateral_Prostate"                                                                                                                    
[21593] "Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                          
[21594] "Duct_Tree_of_Right_Coagulating_Gland"                                                                                                                                 
[21595] "Capsule_of_Left_Coagulating_Gland_of_Prostate"                                                                                                                        
[21596] "Parenchyma_of_Left_Coagulating_Gland_of_Prostate"                                                                                                                     
[21597] "Duct_Tree_of_Left_Coagulating_Gland"                                                                                                                                  
[21598] "Stroma_of_Left_Coagulating_Gland_of_Prostate"                                                                                                                         
[21599] "Primary_Duct_of_Right_Coagulating_Gland"                                                                                                                              
[21600] "Secondary_Duct_of_Right_Coagulating_Gland"                                                                                                                            
[21601] "Tertiary_Duct_of_Right_Coagulating_Gland"                                                                                                                             
[21602] "Periductal_Adventitia_of_Right_Coagulating_Gland"                                                                                                                     
[21603] "Interductal_Stroma_of_Right_Coagulating_Gland"                                                                                                                        
[21604] "Primary_Duct_of_Left_Coagulating_Gland"                                                                                                                               
[21605] "Secondary_Duct_of_Left_Coagulating_Gland"                                                                                                                             
[21606] "Tertiary_Duct_of_Left_Coagulating_Gland"                                                                                                                              
[21607] "Periductal_Adventitia_of_Left_Coagulating_Gland"                                                                                                                      
[21608] "Interductal_Stroma_of_Left_Coagulating_Gland"                                                                                                                         
[21609] "Wall_of_Duct_of_Right_Coagulating_Gland"                                                                                                                              
[21610] "Lumen_of_Duct_of_Right_Coagulating_Gland"                                                                                                                             
[21611] "Urethral_Part_of_Duct_of_Right_Coagulating_Gland"                                                                                                                     
[21612] "Duct_Proper_of_Right_Coagulating_Gland"                                                                                                                               
[21613] "Wall_of_Duct_of_Left_Coagulating_Gland"                                                                                                                               
[21614] "Lumen_of_Duct_of_Left_Coagulating_Gland"                                                                                                                              
[21615] "Urethral_Part_of_Duct_of_Left_Coagulating_Gland"                                                                                                                      
[21616] "Duct_Proper_of_Left_Coagulating_Gland"                                                                                                                                
[21617] "Epithelium_of_Duct_of_Right_Coagulating_Gland"                                                                                                                        
[21618] "Muscle_Layer_of_Duct_of_Right_Coagulating_Gland"                                                                                                                      
[21619] "Adventitia_of_Duct_of_Right_Coagulating_Gland"                                                                                                                        
[21620] "Epithelium_of_Duct_of_Left_Coagulating_Gland"                                                                                                                         
[21621] "Muscle_Layer_of_Duct_of_Left_Coagulating_Gland"                                                                                                                       
[21622] "Adventitia_of_Duct_of_Left_Coagulating_Gland"                                                                                                                         
[21623] "Epithelium_of_Duct_Proper_of_Left_Coagulating_Gland"                                                                                                                  
[21624] "Muscle_Layer_of_Duct_Proper_of_Left_Coagulating_Gland"                                                                                                                
[21625] "Periductal_Adventitia_of_Duct_Proper_of_Left_Coagulating_Gland"                                                                                                       
[21626] "Luminal_Epithelial_Cell_of_Duct_Proper_of_Left_Coagulating_Gland"                                                                                                     
[21627] "Basal_Epithelial_Cell_of_Duct_Proper_of_Left_Coagulating_Gland"                                                                                                       
[21628] "Neuroendocrine_Cell_of_Duct_Proper_of_Left_Coagulating_Gland"                                                                                                         
[21629] "Basement_Membrane_of_Duct_Proper_of_Left_Coagulating_Gland"                                                                                                           
[21630] "Lumen_of_Duct_Proper_of_Left_Coagulating_Gland"                                                                                                                       
[21631] "Lumen_of_Primary_Duct_of_Left_Coagulating_Gland"                                                                                                                      
[21632] "Lumen_of_Secondary_Duct_of_Left_Coagulating_Gland"                                                                                                                    
[21633] "Wall_of_Secondary_Duct_of_Left_Coagulating_Gland"                                                                                                                     
[21634] "Lumen_of_Tertiary_Duct_of_Left_Coagulating_Gland"                                                                                                                     
[21635] "Wall_of_Tertiary_Duct_of_Left_Coagulating_Gland"                                                                                                                      
[21636] "Lumen_of_Duct_Proper_of_Right_Coagulating_Gland"                                                                                                                      
[21637] "Wall_of_Duct_Proper_of_Right_Coagulating_Gland"                                                                                                                       
[21638] "Lumen_of_Primary_Duct_of_Right_Coagulating_Gland"                                                                                                                     
[21639] "Wall_of_Primary_Duct_of_Right_Coagulating_Gland"                                                                                                                      
[21640] "Wall_of_Secondary_Duct_of_Right_Coagulating_Gland"                                                                                                                    
[21641] "Lumen_of_Secondary_Duct_of_Right_Coagulating_Gland"                                                                                                                   
[21642] "Lumen_of_Tertiary_Duct_of_Right_Coagulating_Gland"                                                                                                                    
[21643] "Epithelium_of_Duct_Proper_of_Right_Coagulating_Gland"                                                                                                                 
[21644] "Muscle_Layer_of_Duct_Proper_of_Right_Coagulating_Gland"                                                                                                               
[21645] "Periductal_Adventitia_of_Duct_Proper_of_Right_Coagulating_Gland"                                                                                                      
[21646] "Wall_of_Primary_Duct_of_Left_Coagulating_Gland"                                                                                                                       
[21647] "Wall_of_Tertiary_Duct_of_Right_Coagulating_Gland"                                                                                                                     
[21648] "Epithelium_of_Secondary_Duct_of_Left_Coagulating_Gland"                                                                                                               
[21649] "Muscle_Layer_of_Secondary_Duct_of_Left_Coagulating_Gland"                                                                                                             
[21650] "Periductal_Adventitia_of_Secondary_Duct_of_Left_Coagulating_Gland"                                                                                                    
[21651] "Epithelium_of_Tertiary_Duct_of_Left_Coagulating_Gland"                                                                                                                
[21652] "Muscle_Layer_of_Tertiary_Duct_of_Left_Coagulating_Gland"                                                                                                              
[21653] "Periductal_Adventitia_of_Tertiary_Duct_of_Left_Coagulating_Gland"                                                                                                     
[21654] "Epithelium_of_Primary_Duct_of_Right_Coagulating_Gland"                                                                                                                
[21655] "Muscle_Layer_of_Primary_Duct_of_Right_Coagulating_Gland"                                                                                                              
[21656] "Periductal_Adventitia_of_Primary_Duct_of_Right_Coagulating_Gland"                                                                                                     
[21657] "Epithelium_of_Secondary_Duct_of_Right_Coagulating_Gland"                                                                                                              
[21658] "Muscle_Layer_of_Secondary_Duct_of_Right_Coagulating_Gland"                                                                                                            
[21659] "Periductal_Adventitia_of_Secondary_Duct_of_Right_Coagulating_Gland"                                                                                                   
[21660] "Epithelium_of_Primary_Duct_of_Left_Coagulating_Gland"                                                                                                                 
[21661] "Muscle_Layer_of_Primary_Duct_of_Left_Coagulating_Gland"                                                                                                               
[21662] "Periductal_Adventitia_of_Primary_Duct_of_Left_Coagulating_Gland"                                                                                                      
[21663] "Epithelium_of_Tertiary_Duct_of_Right_Coagulating_Gland"                                                                                                               
[21664] "Muscle_Layer_of_Tertiary_Duct_of_Right_Coagulating_Gland"                                                                                                             
[21665] "Periductal_Adventitia_of_Tertiary_Duct_of_Right_Coagulating_Gland"                                                                                                    
[21666] "Basal_Epithelial_Cell_of_Duct_Proper_of_Right_Coagulating_Gland"                                                                                                      
[21667] "Basement_Membrane_of_Duct_Proper_of_Right_Coagulating_Gland"                                                                                                          
[21668] "Luminal_Epithelial_Cell_of_Duct_Proper_of_Right_Coagulating_Gland"                                                                                                    
[21669] "Neuroendocrine_Cell_of_Duct_Proper_of_Right_Coagulating_Gland"                                                                                                        
[21670] "Basal_Epithelial_Cell_of_Primary_Duct_of_Left_Coagulating_Gland"                                                                                                      
[21671] "Basement_Membrane_of_Primary_Duct_of_Left_Coagulating_Gland"                                                                                                          
[21672] "Luminal_Epithelial_Cell_of_Primary_Duct_of_Left_Coagulating_Gland"                                                                                                    
[21673] "Neuroendocrine_Cell_of_Primary_Duct_of_Left_Coagulating_Gland"                                                                                                        
[21674] "Basal_Epithelial_Cell_of_Secondary_Duct_of_Left_Coagulating_Gland"                                                                                                    
[21675] "Basement_Membrane_of_Secondary_Duct_of_Left_Coagulating_Gland"                                                                                                        
[21676] "Luminal_Epithelial_Cell_of_Secondary_Duct_of_Left_Coagulating_Gland"                                                                                                  
[21677] "Neuroendocrine_Cell_of_Secondary_Duct_of_Left_Coagulating_Gland"                                                                                                      
[21678] "Basal_Epithelial_Cell_of_Tertiary_Duct_of_Left_Coagulating_Gland"                                                                                                     
[21679] "Basement_Membrane_of_Tertiary_Duct_of_Left_Coagulating_Gland"                                                                                                         
[21680] "Luminal_Epithelial_Cell_of_Tertiary_Duct_of_Left_Coagulating_Gland"                                                                                                   
[21681] "Neuroendocrine_Cell_of_Tertiary_Duct_of_Left_Coagulating_Gland"                                                                                                       
[21682] "Basal_Epithelial_Cell_of_Primary_Duct_of_Right_Coagulating_Gland"                                                                                                     
[21683] "Basement_Membrane_of_Primary_Duct_of_Right_Coagulating_Gland"                                                                                                         
[21684] "Luminal_Epithelial_Cell_of_Primary_Duct_of_Right_Coagulating_Gland"                                                                                                   
[21685] "Neuroendocrine_Cell_of_Primary_Duct_of_Right_Coagulating_Gland"                                                                                                       
[21686] "Basement_Membrane_of_Secondary_Duct_of_Right_Coagulating_Gland"                                                                                                       
[21687] "Luminal_Epithelial_Cell_of_Secondary_Duct_of_Right_Coagulating_Gland"                                                                                                 
[21688] "Neuroendocrine_Cell_of_Secondary_Duct_of_Right_Coagulating_Gland"                                                                                                     
[21689] "Basal_Epithelial_Cell_of_Tertiary_Duct_of_Right_Coagulating_Gland"                                                                                                    
[21690] "Basement_Membrane_of_Tertiary_Duct_of_Right_Coagulating_Gland"                                                                                                        
[21691] "Luminal_Epithelial_Cell_of_Tertiary_Duct_of_Right_Coagulating_Gland"                                                                                                  
[21692] "Neuroendocrine_Cell_of_Tertiary_Duct_of_Right_Coagulating_Gland"                                                                                                      
[21693] "Basal_Epithelial_Cell_of_Secondary_Duct_of_Right_Coagulating_Gland"                                                                                                   
[21694] "Wall_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate"                                                                                                            
[21695] "Lumen_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate"                                                                                                           
[21696] "Lumen_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                 
[21697] "Wall_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                  
[21698] "Lumen_of_Secondary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                                
[21699] "Wall_of_Secondary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                                 
[21700] "Lumen_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                                 
[21701] "Wall_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                                  
[21702] "Lumen_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate"                                                                                                          
[21703] "Wall_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate"                                                                                                           
[21704] "Lumen_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                
[21705] "Wall_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                 
[21706] "Lumen_of_Secondary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                               
[21707] "Wall_of_Secondary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                                
[21708] "Lumen_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                                
[21709] "Wall_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                                 
[21710] "Epithelium_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate"                                                                                                      
[21711] "Muscle_Layer_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate"                                                                                                    
[21712] "Periductal_Adventitia_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate"                                                                                           
[21713] "Epithelium_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate"                                                                                            
[21714] "Muscle_Layer_of_Urethral_Part_of_Primary_Duct_of_Dorsolateral_Prostate"                                                                                               
[21715] "Periductal_Adventitia_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate"                                                                                 
[21716] "Epithelium_of_Secondary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                           
[21717] "Muscle_Layer_of_Secondary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                         
[21718] "Periductal_Adventitia_of_Secondary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                
[21719] "Epithelium_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                            
[21720] "Muscle_Layer_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                          
[21721] "Periductal_Adventitia_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                 
[21722] "Epithelium_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate"                                                                                                     
[21723] "Muscle_Layer_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate"                                                                                                   
[21724] "Periductal_Adventitia_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate"                                                                                          
[21725] "Epithelium_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate"                                                                                           
[21726] "Muscle_Layer_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate"                                                                                         
[21727] "Periductal_Adventitia_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate"                                                                                
[21728] "Epithelium_of_Secondary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                          
[21729] "Muscle_Layer_of_Secondary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                        
[21730] "Periductal_Adventitia_of_Secondary_Duct_of_Right_Dorsolateral_Prostate"                                                                                               
[21731] "Epithelium_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                           
[21732] "Muscle_Layer_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                         
[21733] "Basal_Epithelial_Cell_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate"                                                                                           
[21734] "Luminal_Epithelial_Cell_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate"                                                                                         
[21735] "Basement_Membrane_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate"                                                                                               
[21736] "Neuroendocrine_Cell_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate"                                                                                             
[21737] "Basal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate"                                                                                 
[21738] "Basement_Membrane_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate"                                                                                     
[21739] "Luminal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate"                                                                               
[21740] "Neuroendocrine_Cell_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate"                                                                                   
[21741] "Basal_Epithelial_Cell_of_Secondary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                
[21742] "Basement_Membrane_of_Secondary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                    
[21743] "Luminal_Epithelial_Cell_of_Secondary_Duct_of_Left_Dorsolateral_Prostate"                                                                                              
[21744] "Neuroendocrine_Cell_of_Secondary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                  
[21745] "Basal_Epithelial_Cell_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                 
[21746] "Basement_Membrane_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                     
[21747] "Luminal_Epithelial_Cell_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate"                                                                                               
[21748] "Neuroendocrine_Cell_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate"                                                                                                   
[21749] "Basal_Epithelial_Cell_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate"                                                                                          
[21750] "Basement_Membrane_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate"                                                                                              
[21751] "Luminal_Epithelial_Cell_of_Primary_Duct_Proper_of_Right_Dorsolatereal_Prostate"                                                                                       
[21752] "Neuroendocrine_Cell_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate"                                                                                            
[21753] "Basal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate"                                                                                
[21754] "Basement_Membrane_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate"                                                                                    
[21755] "Luminal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate"                                                                              
[21756] "Neuroendocrine_Cell_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate"                                                                                  
[21757] "Basal_Epithelial_Cell_of_Secondary_Duct_of_Right_Dorsolatera_Prostate"                                                                                                
[21758] "Basement_Membrane_of_Secondary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                   
[21759] "Luminal_Epithelial_Cell_of_Secondary_Duct_of_Right_Dorsolateral_Prostate"                                                                                             
[21760] "Neuroendocrine_Cell_of_Secondary_Duct_of_Right_Dorsolateral"                                                                                                          
[21761] "Basal_Epithelial_Cell_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                
[21762] "Basement_Membrane_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                    
[21763] "Luminal_Epithelial_Cell_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate"                                                                                              
[21764] "Neuroendocrine_Cell_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate"                                                                                                  
[21765] "Lumen_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate"                                                                                                        
[21766] "Wall_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate"                                                                                                         
[21767] "Lumen_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                              
[21768] "Wall_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                               
[21769] "Lumen_of_Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                                             
[21770] "Wall_of_Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                                              
[21771] "Lumen_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                                              
[21772] "Wall_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                                               
[21773] "Lumen_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate"                                                                                                       
[21774] "Wall_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate"                                                                                                        
[21775] "Lumen_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                             
[21776] "Wall_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                              
[21777] "Lumen_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                                            
[21778] "Wall_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                                             
[21779] "Lumen_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                                             
[21780] "Wall_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                                              
[21781] "Epithelium_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate"                                                                                                   
[21782] "Muscle_Layer_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate"                                                                                                 
[21783] "Periductal_Adventitia_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate"                                                                                        
[21784] "Epithelium_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                         
[21785] "Muscle_Layer_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                       
[21786] "Epithelium_of_Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                                        
[21787] "Muscle_Layer_of_Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                                      
[21788] "Periductal_Adventitia_of_Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                             
[21789] "Epithelium_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                                         
[21790] "Muscle_Layer_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                                       
[21791] "Periductal_Adventitia_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                              
[21792] "Epithelium_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate"                                                                                                  
[21793] "Muscle_Layer_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate"                                                                                                
[21794] "Periductal_Adventitia_of_Primary_Duct_Proper_of_Right_Lobe_of_Venral_Prostate"                                                                                        
[21795] "Epithelium_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                        
[21796] "Muscle_Layer_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                      
[21797] "Periductal_Adventitia_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                             
[21798] "Epithelium_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                                       
[21799] "Muscle_Layer_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                                     
[21800] "Periductal_Adventitia_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                            
[21801] "Epithelium_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                                        
[21802] "Muscle_Layer_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                                      
[21803] "Basal_Epithelial_Cell_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate"                                                                                        
[21804] "Basement_Membrane_of_Primary_Duct_Proper_of_Left_Lobe_of_Dorsolateral_Prostate"                                                                                       
[21805] "Luminal_Epithelial_Cell_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate"                                                                                      
[21806] "Neuroendocrine_Cell_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate"                                                                                          
[21807] "Basal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                              
[21808] "Basement_Membrane_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                  
[21809] "Luminal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                            
[21810] "Neuroendocrine_Cell_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                
[21811] "Basal_Epithelial_Cell_of_Secondary_Duct_of_Left_Lobe_of_Venral_Prostate"                                                                                              
[21812] "Luminal_Epithelial_Cell_of_Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                           
[21813] "Neuroendocrine_Cell_of_Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                               
[21814] "Basal_Epithelial_Cell_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                              
[21815] "Basement_Membrane_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                                  
[21816] "Luminal_Epithelial_Cell_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                            
[21817] "Neuroendocrine_Cell_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate"                                                                                                
[21818] "Basal_Epithelial_Cell_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate"                                                                                       
[21819] "Basement_Membrane_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate"                                                                                           
[21820] "Luminal_Epithelial_Cell_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate"                                                                                     
[21821] "Neuroendocrine_Cell_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate"                                                                                         
[21822] "Basal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                             
[21823] "Luminal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                           
[21824] "Neuroendocrine_Cell_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                               
[21825] "Basal_Epithelial_Cell_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                            
[21826] "Basement_Membrane_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                                
[21827] "Luminal_Epithelial_Cell_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                          
[21828] "Neuroendocrine_Cell_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                              
[21829] "Basal_Epithelial_Cell_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                             
[21830] "Periductal_Adventitia_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                             
[21831] "Luminal_Epithelial_Cell_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                           
[21832] "Neuroendocrine_Cell_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate"                                                                                               
[21833] "Organism_Modification"                                                                                                                                                
[21834] "Tumor_Cell_Graft"                                                                                                                                                     
[21835] "Knock-out"                                                                                                                                                            
[21836] "Knock-in"                                                                                                                                                             
[21837] "Radiation-Induced_Change"                                                                                                                                             
[21838] "Chemical-Induced_Change"                                                                                                                                              
[21839] "Retrovirus"                                                                                                                                                           
[21840] "Rat_Transgene"                                                                                                                                                        
[21841] "Cardiovascular_System_MMHCC"                                                                                                                                          
[21842] "Heart_MMHCC"                                                                                                                                                          
[21843] "Blood_Vessel_MMHCC"                                                                                                                                                   
[21844] "Digestive_System_MMHCC"                                                                                                                                               
[21845] "Oral_Cavity_MMHCC"                                                                                                                                                    
[21846] "Teeth_MMHCC"                                                                                                                                                          
[21847] "Salivary_Gland_MMHCC"                                                                                                                                                 
[21848] "Salivary_Gland_Parotid_MMHCC"                                                                                                                                         
[21849] "Salivary_Gland_Sublingual_MMHCC"                                                                                                                                      
[21850] "Salivary_Gland_Submandibular_MMHCC"                                                                                                                                   
[21851] "Pharynx_MMHCC"                                                                                                                                                        
[21852] "Tongue_MMHCC"                                                                                                                                                         
[21853] "Esophagus_MMHCC"                                                                                                                                                      
[21854] "Gastrointestinal_Tract_MMHCC"                                                                                                                                         
[21855] "Stomach_MMHCC"                                                                                                                                                        
[21856] "Forestomach_MMHCC"                                                                                                                                                    
[21857] "Stomach_glandular_MMHCC"                                                                                                                                              
[21858] "Stomach_glandular_Pyloric_Antrum_MMHCC"                                                                                                                               
[21859] "Liver_MMHCC"                                                                                                                                                          
[21860] "Liver_fetal_MMHCC"                                                                                                                                                    
[21861] "Liver_Hepatocyte_MMHCC"                                                                                                                                               
[21862] "Liver_Sinusoid_MMHCC"                                                                                                                                                 
[21863] "Liver_Sinusoid_Ito_Cell_MMHCC"                                                                                                                                        
[21864] "Gallbladder_MMHCC"                                                                                                                                                    
[21865] "Intestine_MMHCC"                                                                                                                                                      
[21866] "Intestine_Small_Intestine_MMHCC"                                                                                                                                      
[21867] "Intestine_Small_Intestine_Duodenum_MMHCC"                                                                                                                             
[21868] "Intestine_Small_Intestine_Jejunum_MMHCC"                                                                                                                              
[21869] "Intestine_Small_Intestine_Ileum_MMHCC"                                                                                                                                
[21870] "Intestine_Large_Intestine_MMHCC"                                                                                                                                      
[21871] "Intestine_Large_Intestine_Cecum_MMHCC"                                                                                                                                
[21872] "Intestine_Large_Intestine_Colon_MMHCC"                                                                                                                                
[21873] "Large_Intestine_Colon_Proximal_MMHCC"                                                                                                                                 
[21874] "Large_Intestine_Colon_Medial_MMHCC"                                                                                                                                   
[21875] "Large_Intestine_Colon_Distal_MMHCC"                                                                                                                                   
[21876] "Intestine_Large_Intestine_Rectum_MMHCC"                                                                                                                               
[21877] "Intestine_Large_Intestine_Anus_MMHCC"                                                                                                                                 
[21878] "Integument_System_MMHCC"                                                                                                                                              
[21879] "Skin_MMHCC"                                                                                                                                                           
[21880] "Skin_Anogenital_Region_MMHCC"                                                                                                                                         
[21881] "Skin_Dermis_MMHCC"                                                                                                                                                    
[21882] "Skin_Dorsal_Region_MMHCC"                                                                                                                                             
[21883] "Skin_Epidermis_MMHCC"                                                                                                                                                 
[21884] "Skin_Epidermis_Basal_Cell_MMHCC"                                                                                                                                      
[21885] "Skin_Epidermis_Hair_Matrix_Cell_MMHCC"                                                                                                                                
[21886] "Skin_Epidermis_Keratinocyte_MMHCC"                                                                                                                                    
[21887] "Skin_Melanocyte_MMHCC"                                                                                                                                                
[21888] "Skin_Hair_Follicle_MMHCC"                                                                                                                                             
[21889] "Skin_Gland_MMHCC"                                                                                                                                                     
[21890] "Skin_Gland_Sebaceous_Gland_MMHCC"                                                                                                                                     
[21891] "Skin_Gland_Sweat_Gland_MMHCC"                                                                                                                                         
[21892] "Skin_Gland_Mucous_Gland_MMHCC"                                                                                                                                        
[21893] "Mammary_Gland_MMHCC"                                                                                                                                                  
[21894] "Mammary_Fat_Pad_MMHCC"                                                                                                                                                
[21895] "Lymphohematopoietic_System_MMHCC"                                                                                                                                     
[21896] "Bone_Marrow_MMHCC"                                                                                                                                                    
[21897] "Thymus_MMHCC"                                                                                                                                                         
[21898] "Thymus_Cortex_MMHCC"                                                                                                                                                  
[21899] "Thymus_Medulla_MMHCC"                                                                                                                                                 
[21900] "Spleen_MMHCC"                                                                                                                                                         
[21901] "Spleen_Red_Pulp_MMHCC"                                                                                                                                                
[21902] "Spleen_White_Pulp_MMHCC"                                                                                                                                              
[21903] "Blood_MMHCC"                                                                                                                                                          
[21904] "Blood_fetal_MMHCC"                                                                                                                                                    
[21905] "Lymph_Node_MMHCC"                                                                                                                                                     
[21906] "Peyers_Patch_MMHCC"                                                                                                                                                   
[21907] "Stem_Cell_MMHCC"                                                                                                                                                      
[21908] "Myeloerythroid_Progenitor_MMHCC"                                                                                                                                      
[21909] "Erythroblast_MMHCC"                                                                                                                                                   
[21910] "Erythrocyte_RBC_MMHCC"                                                                                                                                                
[21911] "Megakaryocyte_MMHCC"                                                                                                                                                  
[21912] "Platelet_MMHCC"                                                                                                                                                       
[21913] "Leukoblast_MMHCC"                                                                                                                                                     
[21914] "Leukocyte_WBC_MMHCC"                                                                                                                                                  
[21915] "Leukocyte_Lymphoblast_MMHCC"                                                                                                                                          
[21916] "Leukocyte_Lymphocyte_MMHCC"                                                                                                                                           
[21917] "Leukocyte_Lymphocyte_Immature_B-Lymphocyte_MMHCC"                                                                                                                     
[21918] "Leukocyte_Lymphocyte_Pre-B-Lymphocyte_MMHCC"                                                                                                                          
[21919] "Leukocyte_Lymphocyte_Pro-B-Lymphocyte_MMHCC"                                                                                                                          
[21920] "Leukocyte_Lymphocyte_B-Lymphocyte_MMHCC"                                                                                                                              
[21921] "Leukocyte_Lymphocyte_B-Lymphocyte_Plasma_Cell_MMHCC"                                                                                                                  
[21922] "Leukocyte_Lymphocyte_B-Lymphocyte_Follicular_Center_Cell_MMHCC"                                                                                                       
[21923] "Leukocyte_Lymphocyte_Immature_T-Lymphocyte_MMHCC"                                                                                                                     
[21924] "Leukocyte_Lymphocyte_Pre-T-Lymphocyte_MMHCC"                                                                                                                          
[21925] "Leukocyte_Lymphocyte_Pro-T-Lymphocyte_MMHCC"                                                                                                                          
[21926] "Leukocyte_Lymphocyte_T-Lymphocyte_MMHCC"                                                                                                                              
[21927] "Leukocyte_Lymphocyte_Thymocyte_MMHCC"                                                                                                                                 
[21928] "Leukocyte_Monoblast_MMHCC"                                                                                                                                            
[21929] "Leukocyte_Promonocyte_MMHCC"                                                                                                                                          
[21930] "Leukocyte_Monocyte_MMHCC"                                                                                                                                             
[21931] "Leukocyte_Monocyte_Macrophage_MMHCC"                                                                                                                                  
[21932] "Leukocyte_Monocyte_Macrophage_Histiocyte_MMHCC"                                                                                                                       
[21933] "Leukocyte_Myeloblast_MMHCC"                                                                                                                                           
[21934] "Leukocyte_Myelocyte_Granulocyte_MMHCC"                                                                                                                                
[21935] "Leukocyte_Myelocyte_Granulocyte_Basophil_MMHCC"                                                                                                                       
[21936] "Leukocyte_Myelocyte_Granulocyte_Eosinophil_MMHCC"                                                                                                                     
[21937] "Leukocyte_Myelocyte_Granulocyte_Neutrophil_MMHCC"                                                                                                                     
[21938] "Leukocyte_Myelocyte_Granulocyte_Basophil_Mast_Cell_MMHCC"                                                                                                             
[21939] "Leukocyte_Natural_Killer_Cell_MMHCC"                                                                                                                                  
[21940] "Dendritic_Cell_MMHCC"                                                                                                                                                 
[21941] "Respiratory_System_MMHCC"                                                                                                                                             
[21942] "Larynx_MMHCC"                                                                                                                                                         
[21943] "Trachea_MMHCC"                                                                                                                                                        
[21944] "Lung_MMHCC"                                                                                                                                                           
[21945] "Lung_Alveolus_MMHCC"                                                                                                                                                  
[21946] "Lung_Bronchiole_MMHCC"                                                                                                                                                
[21947] "Lung_Clara_Cell_MMHCC"                                                                                                                                                
[21948] "Nervous_System_MMHCC"                                                                                                                                                 
[21949] "CNS_MMHCC"                                                                                                                                                            
[21950] "CNS_Brain_MMHCC"                                                                                                                                                      
[21951] "CNS_Brain_Astrocyte_MMHCC"                                                                                                                                            
[21952] "CNS_Brain_Brain_Stem_MMHCC"                                                                                                                                           
[21953] "CNS_Brain_Cerebellum_MMHCC"                                                                                                                                           
[21954] "CNS_Brain_Cerebrum_Cortex_MMHCC"                                                                                                                                      
[21955] "CNS_Brain_Choroid_Plexus_MMHCC"                                                                                                                                       
[21956] "CNS_Brain_Ependyma_MMHCC"                                                                                                                                             
[21957] "CNS_Brain_Glial_Cell_MMHCC"                                                                                                                                           
[21958] "CNS_Brain_Hindbrain_MMHCC"                                                                                                                                            
[21959] "CNS_Brain_Hippocampus_MMHCC"                                                                                                                                          
[21960] "CNS_Brain_Hypothalamus_MMHCC"                                                                                                                                         
[21961] "CNS_Brain_Meninges_MMHCC"                                                                                                                                             
[21962] "CNS_Brain_Neuron_MMHCC"                                                                                                                                               
[21963] "CNS_Brain_Olfactory_Bulb_MMHCC"                                                                                                                                       
[21964] "CNS_Brain_Oligodendroglial_Cell_MMHCC"                                                                                                                                
[21965] "CNS_Brain_Optic_Chiasma_MMHCC"                                                                                                                                        
[21966] "CNS_Brain_Striatum_MMHCC"                                                                                                                                             
[21967] "CNS_Brain_Thalamus_MMHCC"                                                                                                                                             
[21968] "CNS_Brain_Undifferentiated_Cell_MMHCC"                                                                                                                                
[21969] "CNS_Spinal_Cord_MMHCC"                                                                                                                                                
[21970] "CNS_Spinal_Cord_Neuron_MMHCC"                                                                                                                                         
[21971] "CNS_Spinal_Cord_Neuron_Ganglion_MMHCC"                                                                                                                                
[21972] "Nerve_MMHCC"                                                                                                                                                          
[21973] "Nerve_Raphe_Nuclei_MMHCC"                                                                                                                                             
[21974] "Neuroblast_MMHCC"                                                                                                                                                     
[21975] "PNS_MMHCC"                                                                                                                                                            
[21976] "PNS_Schwann_Cell_MMHCC"                                                                                                                                               
[21977] "Mouse_Reproductive_System"                                                                                                                                            
[21978] "Endocrine_Gland_System_MMHCC"                                                                                                                                         
[21979] "Adrenal_Gland_MMHCC"                                                                                                                                                  
[21980] "Adrenal_Gland_Cortex_MMHCC"                                                                                                                                           
[21981] "Adrenal_Gland_Medulla_MMHCC"                                                                                                                                          
[21982] "Adrenal_Gland_Subcapsular_Cell_MMHCC"                                                                                                                                 
[21983] "Endocrine_Pancreas_MMHCC"                                                                                                                                             
[21984] "Endocrine_Pancreas_Islet_of_Langerhans_MMHCC"                                                                                                                         
[21985] "Endocrine_Pancreas_Islet_of_Langerhans_Alpha_Cell_MMHCC"                                                                                                              
[21986] "Endocrine_Pancreas_Islet_Cell_of_Langerhans_Beta_Cell_MMHCC"                                                                                                          
[21987] "Exocrine_Pancreas_Acinar_Cell_MMHCC"                                                                                                                                  
[21988] "Parathyroid_Gland_MMHCC"                                                                                                                                              
[21989] "Pineal_Gland_MMHCC"                                                                                                                                                   
[21990] "Pituitary_Gland_MMHCC"                                                                                                                                                
[21991] "Pituitary_Gland_Pars_Anterior_MMHCC"                                                                                                                                  
[21992] "Pituitary_Gland_Pars_Intermedia_MMHCC"                                                                                                                                
[21993] "Pituitary_Gland_Pars_Distalis_MMHCC"                                                                                                                                  
[21994] "Thyroid_Gland_MMHCC"                                                                                                                                                  
[21995] "Thyroid_Gland_Parafollicular_Cell_MMHCC"                                                                                                                              
[21996] "Thyroid_Gland_Follicular_Cell_MMHCC"                                                                                                                                  
[21997] "Female_Reproductive_System_MMHCC"                                                                                                                                     
[21998] "Clitoral_Gland_MMHCC"                                                                                                                                                 
[21999] "Clitoris_MMHCC"                                                                                                                                                       
[22000] "Ovary_MMHCC"                                                                                                                                                          
[22001] "Ovary_Capsule_MMHCC"                                                                                                                                                  
[22002] "Ovary_Germinal_Epithelium_MMHCC"                                                                                                                                      
[22003] "Ovary_Germ_Cell_MMHCC"                                                                                                                                                
[22004] "Ovary_Follicle_MMHCC"                                                                                                                                                 
[22005] "Ovary_Follicular_Cell_MMHCC"                                                                                                                                          
[22006] "Ovary_Granulosa_Cell_MMHCC"                                                                                                                                           
[22007] "Ovary_Interstitial_Cell_MMHCC"                                                                                                                                        
[22008] "Ovary_Lutein_Cell_MMHCC"                                                                                                                                              
[22009] "Ovary_Sertoli_Cell_MMHCC"                                                                                                                                             
[22010] "Ovary_Theca_Cell_MMHCC"                                                                                                                                               
[22011] "Oviduct_MMHCC"                                                                                                                                                        
[22012] "Placenta_MMHCC"                                                                                                                                                       
[22013] "Placenta_Trophoblast_MMHCC"                                                                                                                                           
[22014] "Rete_Ovarii_MMHCC"                                                                                                                                                    
[22015] "Uterus_MMHCC"                                                                                                                                                         
[22016] "Uterus_Cervix_MMHCC"                                                                                                                                                  
[22017] "Uterus_Endometrium_MMHCC"                                                                                                                                             
[22018] "Uterus_Myometrium_MMHCC"                                                                                                                                              
[22019] "Uterus_Serosa_MMHCC"                                                                                                                                                  
[22020] "Vagina_MMHCC"                                                                                                                                                         
[22021] "Vulva_MMHCC"                                                                                                                                                          
[22022] "Yolk_Sac_MMHCC"                                                                                                                                                       
[22023] "Skeletal_System_MMHCC"                                                                                                                                                
[22024] "Osteoblast_MMHCC"                                                                                                                                                     
[22025] "Osteoclast_MMHCC"                                                                                                                                                     
[22026] "Bone_MMHCC"                                                                                                                                                           
[22027] "Bone_Jaw_MMHCC"                                                                                                                                                       
[22028] "Bone_Skull_MMHCC"                                                                                                                                                     
[22029] "Soft_Tissues_MMHCC"                                                                                                                                                   
[22030] "Mesodermal_Cell_Mesoblast_MMHCC"                                                                                                                                      
[22031] "Lymphatic_Vessel_MMHCC"                                                                                                                                               
[22032] "Cartilage_MMHCC"                                                                                                                                                      
[22033] "Ligament_MMHCC"                                                                                                                                                       
[22034] "Tendon_MMHCC"                                                                                                                                                         
[22035] "Muscle_MMHCC"                                                                                                                                                         
[22036] "Muscle_Immature_MMHCC"                                                                                                                                                
[22037] "Muscle_Smooth_MMHCC"                                                                                                                                                  
[22038] "Muscle_Striated_MMHCC"                                                                                                                                                
[22039] "Muscle_Striated_Cardiac_MMHCC"                                                                                                                                        
[22040] "Muscle_Striated_Skeletal_MMHCC"                                                                                                                                       
[22041] "Myoepitheliocyte_MMHCC"                                                                                                                                               
[22042] "Muscle_Striated_Skeletal_Diaphragm_MMHCC"                                                                                                                             
[22043] "Connective_Tissue_MMHCC"                                                                                                                                              
[22044] "Connective_Tissue_Fibroblasts_MMHCC"                                                                                                                                  
[22045] "Connective_Tissue_Mesentery_MMHCC"                                                                                                                                    
[22046] "Connective_Tissue_Mesothelium_MMHCC"                                                                                                                                  
[22047] "Adipose_Tissue_MMHCC"                                                                                                                                                 
[22048] "Adipose_Tissue_Brown_MMHCC"                                                                                                                                           
[22049] "Adipose_Tissue_White_MMHCC"                                                                                                                                           
[22050] "Mediastinum_MMHCC"                                                                                                                                                    
[22051] "Periosteum_MMHCC"                                                                                                                                                     
[22052] "Peritoneum_MMHCC"                                                                                                                                                     
[22053] "Synovial_Membrane_MMHCC"                                                                                                                                              
[22054] "Special_Sensory_Organs_MMHCC"                                                                                                                                         
[22055] "Eye_MMHCC"                                                                                                                                                            
[22056] "Ear_MMHCC"                                                                                                                                                            
[22057] "Ear_Inner_Ear_Cochlea_MMHCC"                                                                                                                                          
[22058] "Ear_Middle_Ear_MMHCC"                                                                                                                                                 
[22059] "Ear_Outer_Ear_External_MMHCC"                                                                                                                                         
[22060] "Eye_Conjunctiva_MMHCC"                                                                                                                                                
[22061] "Eye_Cornea_MMHCC"                                                                                                                                                     
[22062] "Eye_Iris_MMHCC"                                                                                                                                                       
[22063] "Eye_Harderian_Gland_MMHCC"                                                                                                                                            
[22064] "Eye_Lacrimal_Gland_MMHCC"                                                                                                                                             
[22065] "Eye_Lens_MMHCC"                                                                                                                                                       
[22066] "Eye_Retina_MMHCC"                                                                                                                                                     
[22067] "Nose_MMHCC"                                                                                                                                                           
[22068] "Nose_Nasal_Cavity_MMHCC"                                                                                                                                              
[22069] "Nose_Nasal_Cavity_Nasal_Gland_MMHCC"                                                                                                                                  
[22070] "Nose_Nasal_Cavity_Olfactory_Cell_MMHCC"                                                                                                                               
[22071] "Nose_Olfactory_Glands_MMHCC"                                                                                                                                          
[22072] "Urinary_System_MMHCC"                                                                                                                                                 
[22073] "Bladder_MMHCC"                                                                                                                                                        
[22074] "Kidney_MMHCC"                                                                                                                                                         
[22075] "Kidney_Cortex_MMHCC"                                                                                                                                                  
[22076] "Kidney_Cortex_Glomerulus_MMHCC"                                                                                                                                       
[22077] "Kidney_Cortex_Renal_Tubule_MMHCC"                                                                                                                                     
[22078] "Kidney_Cortex_Renal_Tubule_Collecting_Duct_MMHCC"                                                                                                                     
[22079] "Kidney_Cortex_Renal_Tubule_Loop_of_Henle_MMHCC"                                                                                                                       
[22080] "Kidney_Medulla_MMHCC"                                                                                                                                                 
[22081] "Renal_Pelvis_MMHCC"                                                                                                                                                   
[22082] "Ureter_MMHCC"                                                                                                                                                         
[22083] "Urethra_MMHCC"                                                                                                                                                        
[22084] "Urethra_Gland_MMHCC"                                                                                                                                                  
[22085] "Mouse_Ovarian_Tumors_Histological_Classification"                                                                                                                     
[22086] "Surface_Epithelial-Stromal_Tumors_of_the_Mouse_Ovary"                                                                                                                 
[22087] "Serous_Tumors_of_the_Mouse_Ovary"                                                                                                                                     
[22088] "Benign_Serous_Tumors_of_the_Mouse_Ovary"                                                                                                                              
[22089] "Serous_Cystadenoma_of_the_Mouse_Ovary"                                                                                                                                
[22090] "Papillary_Serous_Cystadenoma_of_the_Mouse_Ovary"                                                                                                                      
[22091] "Surface_Papilloma_of_the_Mouse_Ovary"                                                                                                                                 
[22092] "Serous_Adenofibroma_of_the_Mouse_Ovary_Benign_Serous_Cystadenofibroma_of_the_Mouse_Ovary"                                                                             
[22093] "Mouse_Serous_Ovarian_Tumors_of_Borderline_Malignancy"                                                                                                                 
[22094] "Mouse_Serous_Cystic_Ovarian_Tumors_of_Borderline_Malignancy"                                                                                                          
[22095] "Mouse_Papillary_Serous_Cystic_Ovarian_Tumors_of_Borderline_Malignancy"                                                                                                
[22096] "Mouse_Surface_Papillary_Serous_Ovarian_Tumors_of_Borderline_Malignancy"                                                                                               
[22097] "Mouse_Serous_Ovarian_Adenofibroma_of_Borderline_Malignancy_Mouse_Serous_Ovarian_Cystadenofibroma_of_Borderline_Malignancy"                                            
[22098] "Malignant_Serous_Tumors_of_the_Mouse_Ovary"                                                                                                                           
[22099] "Serous_Adenocarcinoma_of_the_Mouse_Ovary"                                                                                                                             
[22100] "Papillary_Serous_Adenocarcinoma_of_the_Mouse_Ovary"                                                                                                                   
[22101] "Papillary_Serous_Cystadenocarcinoma_of_the_Mouse_Ovary"                                                                                                               
[22102] "Surface_Papillary_Serous_Adenocarcinoma_of_the_Mouse_Ovary"                                                                                                           
[22103] "Serous_Adenocarcinofibroma_of_the_Mouse_Ovary_Serous_Cystadenocarcinofibroma_of_the_Mouse_Ovary"                                                                      
[22104] "Mucinous_Tumors_of_the_Mouse_Ovary_Endocervical-like_and_Intestinal_Types"                                                                                            
[22105] "Benign_Mucinous_Tumors_of_the_Mouse_Ovary"                                                                                                                            
[22106] "Mucinous_Cystadenoma_of_the_Mouse_Ovary"                                                                                                                              
[22107] "Mucinous_Adenofibroma_of_the_Mouse_Ovary_Mucinous_Cystadenofibroma_of_the_Mouse_Ovary"                                                                                
[22108] "Mucinous_Tumors_of_the_Mouse_Ovary_of_Borderline_Malignancy"                                                                                                          
[22109] "Mucinous_Cystic_Tumors_of_the_Mouse_Ovary_of_Borderline_Malignancy"                                                                                                   
[22110] "Mucinous_Adenofibroma_of_the_Mouse_Ovary_of_Borderline_Malignancy_Mucinous_Cystadenofibroma_of_the_Mouse_Ovary_of_Borderline_Malignancy"                              
[22111] "Malignant_Mucinous_Tumors_of_the_Mouse_Ovary"                                                                                                                         
[22112] "Mucinous_Adenocarcinoma_of_the_Mouse_Ovary"                                                                                                                           
[22113] "Mucinous_Cystadenocarcinoma_of_the_Mouse_Ovary"                                                                                                                       
[22114] "Mucinous_Adenocarcinofibroma_of_the_Mouse_Ovary_Mucinous_Cystadenocarcinofibroma_of_the_Mouse_Ovary"                                                                  
[22115] "Mouse_Endometrioid_Tumors"                                                                                                                                            
[22116] "Benign_Endometrioid_Tumors_of_the_Mouse_Ovary"                                                                                                                        
[22117] "Endometrioid_Cystadenoma_of_the_Mouse_Ovary"                                                                                                                          
[22118] "Benign_Endometrioid_Cystadenoma_of_the_Mouse_Ovary_with_Squamous_Differentiation"                                                                                     
[22119] "Endometrioid_Adenofibroma_of_the_Mouse_Ovary_Endrometrioid_Cystadenofibroma_of_the_Mouse_Ovary"                                                                       
[22120] "Benign_Endometrioid_Adenofibroma_of_the_Mouse_Ovary_Benign_Endometrioid_Cystadenofibroma_of_the_Mouse_Ovary_with_Squamous_Differentiation"                            
[22121] "Mouse_Endometrioid_Ovarian_Tumors_of_Borderline_Malignancy"                                                                                                           
[22122] "Mouse_Endometrioid_Cystic_Ovarian_Tumors_of_Borderline_Malignancy"                                                                                                    
[22123] "Mouse_Endometrioid_Cystic_Ovarian_Tumors_of_Borderline_Malignancy_with_Squamous_Differentiation"                                                                      
[22124] "Mouse_Endometrioid_Ovarian_Adenofibroma_of_Borderline_Malignancy_Mouse_Endometrioid_Ovarian_Cystadenofibroma_of_Borderline_Malignancy"                                
[22125] "Mouse_Endometrioid_Ovarian_Adenofibroma_of_Borderline_Malignancy_Mouse_Endometrioid_Ovarian_Cystadenofibroma_of_Borderline_Malignancy_with_Squamous_Differentiation"  
[22126] "Malignant_Endometrioid_Tumors_of_the_Mouse_Ovary"                                                                                                                     
[22127] "Endometrioid_Adenocarcinoma_of_the_Mouse_Ovary_Endometrioid_Cystadenocarcinoma_of_the_Mouse_Ovary"                                                                    
[22128] "Endometrioid_Adenocarcinoma_of_the_Mouse_Ovary_Endometrioid_Cystadenocarcinoma_of_the_Mouse_Ovary_with_Squamous_Differentiation"                                      
[22129] "Endometrioid_Adenocarcinoma_of_the_Mouse_Ovary_Endometrioid_Cystadenocarcinofibroma_of_the_Mouse_Ovary"                                                               
[22130] "Endometrioid_Adenocarcinoma_of_the_Mouse_Ovary_Endometrioid_Cystadenocarcinofibroma_of_the_Mouse_Ovary_with_Squamous_Differentiation"                                 
[22131] "Epithelial-Stromal_and_Stromal_Endometrioid_Tumors_of_the_Mouse_Ovary"                                                                                                
[22132] "Endometrioid_Adenosarcoma_of_the_Mouse_Ovary_Homologous_Heterologous"                                                                                                 
[22133] "Malignant_Mesodermal_Mullerian_Mixed_Tumor_of_the_Mouse_Ovary_carcinosarcoma_Homologous_Heterologous"                                                                 
[22134] "Stromal_Sarcoma_of_the_Mouse_Ovary"                                                                                                                                   
[22135] "Clear_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                                 
[22136] "Benign_Clear_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                          
[22137] "Clear_Cell_Cystadenoma_of_the_Mouse_Ovary"                                                                                                                            
[22138] "Clear_Cell_Adenofibroma_of_the_Mouse_Ovary_Clear_Cell_Cystadenofibroma_of_the_Mouse_Ovary"                                                                            
[22139] "Mouse_Clear_Cell_Ovarian_Tumors_of_Borderline_Malignancy"                                                                                                             
[22140] "Mouse_Clear_Cell_Cystic_Ovarian_Tumor_of_Borderline_Malignancy"                                                                                                       
[22141] "Malignant_Clear_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                       
[22142] "Clear_Cell_Adenocarcinoma_of_the_Mouse_Ovary"                                                                                                                         
[22143] "Clear_Cell_Adenocarcinofibroma_of_the_Mouse_Ovary_Clear_Cell_Cystadenocarcinofibroma_of_the_Mouse_Ovary"                                                              
[22144] "Transitional_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                          
[22145] "Mouse_Brenner_Tumor"                                                                                                                                                  
[22146] "Mouse_Proliferating_Brenner_Tumor_of_Borderline_Malignancy"                                                                                                           
[22147] "Malignant_Mouse_Brenner_Tumor"                                                                                                                                        
[22148] "Transitional_Cell_Non-Brenner_Type_Carcinoma_of_the_Ovary"                                                                                                            
[22149] "Squamous_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                              
[22150] "Mixed_Epithelial_Tumors_of_the_Mouse_Ovary_specify_Components"                                                                                                        
[22151] "Benign_Mixed_Epithelial_Tumors_of_the_Mouse_Ovary"                                                                                                                    
[22152] "Mouse_Mixed_Epithelial_Ovarian_Tumors_of_Borderline_Malignancy"                                                                                                       
[22153] "Malignant_Mixed_Epithelial_Tumors_of_the_Mouse_Ovary"                                                                                                                 
[22154] "Undifferentiated_Carcinoma_of_the_Mouse_Ovary"                                                                                                                        
[22155] "Sex_Cord-Stromal_Tumors_of_the_Mouse_Ovary"                                                                                                                           
[22156] "Granulosa-Stromal_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                     
[22157] "Granulosa_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                             
[22158] "Adult_Granulosa_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                       
[22159] "Juvenile_Granulosa_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                    
[22160] "Mouse_Thecoma-fibroma_Group"                                                                                                                                          
[22161] "Mouse_Thecoma"                                                                                                                                                        
[22162] "Fibroma_of_the_Mouse_Ovary"                                                                                                                                           
[22163] "Cellular_Fibroma_of_the_Mouse_Ovary"                                                                                                                                  
[22164] "Fibrosarcoma_of_the_Mouse_Ovary"                                                                                                                                      
[22165] "Stromal_Tumor_of_the_Mouse_Ovary_with_Minor_Sex_Cord_Elements"                                                                                                        
[22166] "Sclerosing_Stromal_Tumor_of_the_Mouse_Ovary"                                                                                                                          
[22167] "Stromal_Luteoma_of_the_Mouse_Ovary"                                                                                                                                   
[22168] "Unclassified_Thecoma-Fibroma_Type_Tumors_of_the_Mouse_Ovary"                                                                                                          
[22169] "Other_Thecoma-Fibroma_Type_Tumors_of_the_Mouse_Ovary_Not_Specified"                                                                                                   
[22170] "Sertoli-Stromal_Cell_Tumors_of_the_Mouse_Ovary_Androblastomas"                                                                                                        
[22171] "Well_Differentiated_Sertoli-Stromal_Cell_Tumors_of_the_Ovary_and_Androblastomas"                                                                                      
[22172] "Sertoli_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                               
[22173] "Sertoli-Leydig_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                        
[22174] "Leydig_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                                
[22175] "Mouse_Sertoli-Leydig_Cell_Ovarian_Tumors_of_Intermediate_Differentiation"                                                                                             
[22176] "Mouse_Sertoli-Leydig_Cell_Ovarian_Tumors_of_Intermediate_Differentiation_with_Heterologous_Elements"                                                                  
[22177] "Mouse_Sertoli-Leydig_Cell_Ovarian_Tumor_Poorly_Differentiated_sarcomatoid"                                                                                            
[22178] "Mouse_Sertoli-Leydig_Cell_Tumor_Poorly_Differentiated_with_Heterologous_Elements"                                                                                     
[22179] "Retiform_Sertoli-Stromal_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                              
[22180] "Mouse_Sertoli-Leydig_Cell_Tumor_Retiform_with_Heterologous_Elements"                                                                                                  
[22181] "Sex_Cord_Tumors_of_the_Mouse_Ovary_with_Annular_Tubules"                                                                                                              
[22182] "Mouse_Gynandroblastoma"                                                                                                                                               
[22183] "Unclassified_Sex_Cord_Stromal_Tumors_of_the_Mouse_Ovary"                                                                                                              
[22184] "Steroid_Lipid_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                         
[22185] "Steroid_Stromal_Luteoma_of_the_Ovary"                                                                                                                                 
[22186] "Steroid_Leydig_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                        
[22187] "Hilus_Cell_Tumor_of_the_Mouse_Ovary"                                                                                                                                  
[22188] "Leydig_Cell_Tumor_of_the_Mouse_Ovary_Non-Hilar_Type"                                                                                                                  
[22189] "Unclassified_Steroid_Lipid_Cell_Tumors_of_the_Mouse_Ovary_NOS"                                                                                                        
[22190] "Germ_Cell_Tumors_of_the_Mouse_Ovary"                                                                                                                                  
[22191] "Mouse_Dysgerminoma"                                                                                                                                                   
[22192] "Mouse_Disgerminoma_Variant_with_Syncytiotrophoblast_Cells"                                                                                                            
[22193] "Yolk_Sac_Tumor_of_the_Mouse_Ovary"                                                                                                                                    
[22194] "Polyvesicular_Vitelline_Tumor_of_the_Mouse_Ovary"                                                                                                                     
[22195] "Hepatoid_Yolk_Sac_Tumors_of_the_Mouse_Ovary"                                                                                                                          
[22196] "Glandular_Yolk_Sac_Tumors_of_the_Mouse_Ovary"                                                                                                                         
[22197] "Mouse_Embryonal_Carcinoma"                                                                                                                                            
[22198] "Mouse_Polyembryoma"                                                                                                                                                   
[22199] "Murine_Choriocarcinoma"                                                                                                                                               
[22200] "Teratomas_of_the_Mouse_Ovary"                                                                                                                                         
[22201] "Immature_Teratoma_of_the_Mouse_Ovary"                                                                                                                                 
[22202] "Mature_Teratoma_of_the_Mouse_Ovary"                                                                                                                                   
[22203] "Mature_Solid_Teratoma_of_the_Mouse_Ovary"                                                                                                                             
[22204] "Mature_Cystic_Teratoma_of_the_Mouse_Ovary"                                                                                                                            
[22205] "Teratoma_of_the_Mouse_Ovary_with_Malignant_Transformation"                                                                                                            
[22206] "Mature_Teratoma_of_the_Mouse_Ovary_Foetiform"                                                                                                                         
[22207] "Monodermal_Teratoma_of_the_Mouse_Ovary"                                                                                                                               
[22208] "Mouse_Struma_Ovarii"                                                                                                                                                  
[22209] "Carcinoid_Tumor_of_the_Mouse_Ovary"                                                                                                                                   
[22210] "Strumal_Carcinoid_Tumor_of_the_Mouse_Ovary"                                                                                                                           
[22211] "Goblet_Cell_Carcinoid_Tumor_of_the_Mouse_Ovary"                                                                                                                       
[22212] "Neuroectodermal_Tumors_of_the_Mouse_Ovary_specify_Type"                                                                                                               
[22213] "Sebaceous_Tumors_of_the_Mouse_Ovary"                                                                                                                                  
[22214] "Other_Monodermal_Teratomas_of_the_Mouse_Ovary"                                                                                                                        
[22215] "Mixed_Germ_Cell_Tumors_of_the_Mouse_Ovary_specify_Components"                                                                                                         
[22216] "Gonadoblastoma_of_the_Mouse_Ovary"                                                                                                                                    
[22217] "Gonadoblastoma_Variant_of_the_Mouse_Ovary_with_Dysgerminoma_or_Other_Germ_Cell_Tumor"                                                                                 
[22218] "Germ_Cell_Sex_Cord-Stromal_Tumors_of_the_Mouse_Ovary_of_Non-gonadoblastoma_Type"                                                                                      
[22219] "Germ_Cell_Sex_Cord-stromal_Tumors_of_the_Mouse_Ovary_Non-gonadoblastoma_Variant_with_Dysgerminoma_or_Other_Germ_Cell_Tumor"                                           
[22220] "Mouse_Tumors_of_Rete_Ovarii"                                                                                                                                          
[22221] "Mouse_Adenoma_of_Rete_Ovarii"                                                                                                                                         
[22222] "Mouse_Cystadenoma_of_Rete_Ovarii"                                                                                                                                     
[22223] "Mouse_Adenocarcinoma_of_Rete_Ovarii"                                                                                                                                  
[22224] "Mesothelial_Tumors_of_the_Mouse_Ovary"                                                                                                                                
[22225] "Adenomatoid_Tumors_of_the_Mouse_Ovary"                                                                                                                                
[22226] "Mesothelioma_of_the_Mouse_Ovary"                                                                                                                                      
[22227] "Tumors_of_Uncertain_Origin_and_Miscellaneous_Tumors_of_the_Mouse_Ovary"                                                                                               
[22228] "Small_Cell_Carcinoma_of_the_Mouse_Ovary"                                                                                                                              
[22229] "Tumors_of_the_Mouse_Ovary_of_Probable_Wolffian_Origin"                                                                                                                
[22230] "Hepatoid_Carcinoma_of_the_Mouse_Ovary"                                                                                                                                
[22231] "Mouse_Myxoma"                                                                                                                                                         
[22232] "Other_Tumors_of_the_Mouse_Ovary_of_Uncertain_Origin_or_Miscellaneous"                                                                                                 
[22233] "Gestational_Trophoblastic_Diseases_of_the_Mouse_Ovary"                                                                                                                
[22234] "Mouse_Soft_Tissue_Ovarian_Tumors_Not_Specific_to_Ovary"                                                                                                               
[22235] "Malignant_Lymphomas_Leukemias_and_Plasmacytoma_of_the_Mouse_Ovary"                                                                                                    
[22236] "Unclassified_Tumors_of_the_Mouse_Ovary"                                                                                                                               
[22237] "Secondary_Metastatic_Tumors_of_the_Mouse_Ovary"                                                                                                                       
[22238] "Tumor-Like_Lesions_of_the_Ovary"                                                                                                                                      
[22239] "Solitary_Follicle_Cyst_of_the_Ovary"                                                                                                                                  
[22240] "Multiple_Follicle_Cysts_of_the_Ovary"                                                                                                                                 
[22241] "Large_Solitary_Luteinized_Follicle_Cyst_of_Pregnancy_and_Puerperium"                                                                                                  
[22242] "Hyperreactio_Luteinalis"                                                                                                                                              
[22243] "Hyperreactio_Luteinalis_Variant_with_Corpora_Lutea"                                                                                                                   
[22244] "Mouse_Corpus_Luteum_Cyst"                                                                                                                                             
[22245] "Pregnancy_Luteoma"                                                                                                                                                    
[22246] "Mouse_Ectopic_Pregnancy"                                                                                                                                              
[22247] "Mouse_Stromal_Hyperplasia"                                                                                                                                            
[22248] "Stromal_Hyperthecosis"                                                                                                                                                
[22249] "Massive_Oedema"                                                                                                                                                       
[22250] "Fibromatosis_of_the_Ovary"                                                                                                                                            
[22251] "Endometriosis_of_the_Ovary"                                                                                                                                           
[22252] "Cyst_of_the_Ovary_Unclassified"                                                                                                                                       
[22253] "Inflammatory_Lesions_of_the_Ovary"                                                                                                                                    
[22254] "Mouse_Primary_Cardiac_Tumors"                                                                                                                                         
[22255] "Mouse_Cardiac_Sarcoma"                                                                                                                                                
[22256] "Mouse_Cardiac_Angiosarcoma"                                                                                                                                           
[22257] "Mouse_Cardiac_Rhabdomyosarcoma"                                                                                                                                       
[22258] "Mouse_Cardiac_Mesothelioma"                                                                                                                                           
[22259] "Mouse_Cardiac_Fibrosarcoma"                                                                                                                                           
[22260] "Mouse_Cardiac_Malignant_Fibrous_Histiocytoma"                                                                                                                         
[22261] "Mouse_Cardiac_Kaposi_s_Sarcoma"                                                                                                                                       
[22262] "Mouse_Cardiovascular_System_Neoplasms"                                                                                                                                
[22263] "Mouse_Primary_Tumors_of_the_Blood_Vessel"                                                                                                                             
[22264] "Hemangioma_of_the_Mouse_Blood_Vessel"                                                                                                                                 
[22265] "Hemangiosarcoma_of_the_Mouse_Blood_Vessel"                                                                                                                            
[22266] "Cavernous_Hemangioma_of_the_Mouse_Blood_Vessel"                                                                                                                       
[22267] "Venous_Hemangioma_of_the_Mouse_Blood_Vessel"                                                                                                                          
[22268] "Racemose_Hemangioma_of_the_Mouse_Blood_Vessel"                                                                                                                        
[22269] "Epithelioid_Hemangioma_of_the_Mouse_Blood_Vessel_NOS"                                                                                                                 
[22270] "Epithelioid_Hemangioma_of_the_Mouse_Blood_Vessel_Malignant"                                                                                                           
[22271] "Epithelioid_Hemangioma_of_the_Mouse_Blood_Vessel"                                                                                                                     
[22272] "Hemangioma_of_the_Mouse_Blood_Vessel_NOS"                                                                                                                             
[22273] "Hemangioendothelioma_of_the_Mouse_Blood_Vessel_Benign"                                                                                                                
[22274] "Hemangioendothelioma_of_the_Mouse_Blood_Vessel_NOS"                                                                                                                   
[22275] "Hemangioendothelioma_of_the_Mouse_Blood_Vessel_Malignant"                                                                                                             
[22276] "Capillary_Hemangioma_of_the_Mouse_Blood_Vessel"                                                                                                                       
[22277] "Intramuscular_Hemangioma_of_the_Mouse_Blood_Vessel"                                                                                                                   
[22278] "Kupffer_Cell_Sarcoma_of_the_Mouse_Blood_Vessel"                                                                                                                       
[22279] "Endovascular_Papillary_Angioendothelioma_of_the_Mouse_Blood_Vessel"                                                                                                   
[22280] "Spindle_Cell_Hemangioendothelioma_of_the_Mouse_Blood_Vessel"                                                                                                          
[22281] "Kaposi_Sarcoma_of_the_Mouse_Blood_Vessel"                                                                                                                             
[22282] "Angiokeratoma_of_the_Mouse_Blood_Vessel"                                                                                                                              
[22283] "Verrucous_Keratotic_Hemangioma_of_the_Mouse_Blood_Vessel"                                                                                                             
[22284] "Hemangiopericytoma_of_the_Mouse_Blood_Vessel_Benign"                                                                                                                  
[22285] "Hemangiopericytoma_of_the_Mouse_Blood_Vessel_NOS"                                                                                                                     
[22286] "Hemangiopericytoma_of_the_Mouse_Blood_Vessel_Malignant"                                                                                                               
[22287] "Angiofibroma_of_the_Mouse_Blood_Vessel_NOS"                                                                                                                           
[22288] "Acquired_Tufted_Hemangioma_of_the_Mouse_Blood_Vessel"                                                                                                                 
[22289] "Hemangioblastoma_of_the_Mouse_Blood_Vessel"                                                                                                                           
[22290] "Mouse_Skeletal_System_Neoplasms"                                                                                                                                      
[22291] "Osteoma_of_the_Mouse_Skeletal_System_NOS"                                                                                                                             
[22292] "Osteosarcoma_of_the_Mouse_Skeletal_System_NOS"                                                                                                                        
[22293] "Osteosarcoma_of_the_Mouse_Skeletal_System"                                                                                                                            
[22294] "Chondroblastic_Osteosarcoma_of_the_Mouse_Skeletal_System"                                                                                                             
[22295] "Fibroblastic_Osteosarcoma_of_the_Mouse_Skeletal_System"                                                                                                               
[22296] "Telangiectatic_Osteosarcoma_of_the_Mouse_Skeletal_System"                                                                                                             
[22297] "Osteosarcoma_in_Paget_Disease_of_the_Mouse_Skeletal_System"                                                                                                           
[22298] "Small_Cell_Osteosarcoma_of_the_Mouse_Skeletal_System"                                                                                                                 
[22299] "Central_Osteosarcoma_of_the_Mouse_Skeletal_System"                                                                                                                    
[22300] "Intraosseous_Well_Differentiated_Osteosarcoma_of_the_Mouse_Skeletal_System"                                                                                           
[22301] "Osteoid_Osteoma_of_the_Mouse_Skeletal_System_NOS"                                                                                                                     
[22302] "Parosteal_Osteosarcoma_of_the_Mouse_Skeletal_System"                                                                                                                  
[22303] "Periosteal_Osteosarcoma_of_the_Mouse_Skeletal_System"                                                                                                                 
[22304] "High_Grade_Surface_Osteosarcoma_of_the_Mouse_Skeletal_System"                                                                                                         
[22305] "Intracortical_Osteosarcoma_of_the_Mouse_Skeletal_System"                                                                                                              
[22306] "Osteoblastoma_of_the_Mouse_Skeletal_System_NOS"                                                                                                                       
[22307] "Aggressive_Osteoblastoma_of_the_Mouse_Skeletal_System"                                                                                                                
[22308] "Osteochondroma_of_the_Mouse_Skeletal_System"                                                                                                                          
[22309] "Osteochondromatosis_of_the_Mouse_Skeletal_System_NOS"                                                                                                                 
[22310] "Chondroma_of_the_Mouse_Skeletal_System_NOS"                                                                                                                           
[22311] "Chondromatosis_of_the_Mouse_Skeletal_System_NOS"                                                                                                                      
[22312] "Chondrosarcoma_of_the_Mouse_Skeletal_System_NOS"                                                                                                                      
[22313] "Juxtacortical_Chondroma_of_the_Mouse_Skeletal_System"                                                                                                                 
[22314] "Juxtacortical_Chondrosarcoma_of_the_Mouse_Skeletal_System"                                                                                                            
[22315] "Chondroblastoma_of_the_Mouse_Skeletal_System_NOS"                                                                                                                     
[22316] "Chondroblastoma_of_the_Mouse_Skeletal_System_Malignant"                                                                                                               
[22317] "Myxoid_Chondrosarcoma_of_the_Mouse_Skeletal_System"                                                                                                                   
[22318] "Mesenchymal_Chondrosarcoma_of_the_Mouse_Skeletal_System"                                                                                                              
[22319] "Chondromyxoid_Fibroma_of_the_Mouse_Skeletal_System"                                                                                                                   
[22320] "Clear_Cell_Chondrosarcoma_of_the_Mouse_Skeletal_System"                                                                                                               
[22321] "Dedifferentiated_Chondrosarcoma_of_the_Mouse_Skeletal_System"                                                                                                         
[22322] "Giant_Cell_Tumor_of_Bone_of_the_Mouse_Skeletal_System_NOS"                                                                                                            
[22323] "Giant_Cell_Tumor_of_Bone_of_the_Mouse_Skeletal_System_Malignant"                                                                                                      
[22324] "Mouse_Endocrine_Gland_System_Neoplasms"                                                                                                                               
[22325] "Murine_Islet_Cell_Adenoma"                                                                                                                                            
[22326] "Mouse_Islet_Cell_Tumor_NOS"                                                                                                                                           
[22327] "Murine_Islet_Cell_Carcinoma"                                                                                                                                          
[22328] "Mouse_Insulinoma_NOS"                                                                                                                                                 
[22329] "Malignant_Mouse_Insulinoma"                                                                                                                                           
[22330] "Mouse_Glucagonoma_NOS"                                                                                                                                                
[22331] "Malignant_Mouse_Glucagonoma"                                                                                                                                          
[22332] "Mixed_Mouse_Islet_Cell_and_Exocrine_Adenocarcinoma"                                                                                                                   
[22333] "Mouse_Pituitary_Adenoma_NOS"                                                                                                                                          
[22334] "Mouse_Pituitary_Carcinoma_NOS"                                                                                                                                        
[22335] "Mouse_Adrenal_Cortical_Adenoma_NOS"                                                                                                                                   
[22336] "Mouse_Adrenal_Cortical_Carcinoma"                                                                                                                                     
[22337] "Mouse_Adrenal_Cortical_Adenoma_Compact_Cell"                                                                                                                          
[22338] "Mouse_Adrenal_Cortical_Adenoma"                                                                                                                                       
[22339] "Mouse_Adrenal_Cortical_Adenoma_Pigmented"                                                                                                                             
[22340] "Mouse_Adrenal_Cortical_Adenoma_Clear_Cell"                                                                                                                            
[22341] "Mouse_Adrenal_Cortical_Adenoma_Glomerulosa_Cell"                                                                                                                      
[22342] "Mouse_Adrenal_Cortical_Adenoma_Mixed_Cell"                                                                                                                            
[22343] "T_Cell_Neoplasms_of_Undetermined_Character_of_the_Mouse_Hematologic_System"                                                                                           
[22344] "Burkitt-like_Lymphoma_of_the_Mouse_Hematologic_System"                                                                                                                
[22345] "Morphologic_Variants_of_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System"                                                                                
[22346] "Subtypes_of_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System"                                                                                            
[22347] "Soft_Tissue_Tumors_of_the_Murine_Pulmonary_System"                                                                                                                    
[22348] "Mesothelial_Tumors_of_the_Mouse_Pulmonary_System"                                                                                                                     
[22349] "Miscellaneous_Tumors_of_the_Mouse_Pulmonary_System"                                                                                                                   
[22350] "Lymphoproliferative_Tumors_of_the_Mouse_Pulmonary_System"                                                                                                             
[22351] "Secondary_Tumors_of_the_Murine_Pulmonary_System"                                                                                                                      
[22352] "Unclassified_Tumors_of_the_Mouse_Pulmonary_System"                                                                                                                    
[22353] "Tumor-Like_Diseases_of_the_Mouse_Pulmonary_System"                                                                                                                    
[22354] "Staining_Methods"                                                                                                                                                     
[22355] "Hematoxylin_and_Eosin_Staining_Method"                                                                                                                                
[22356] "Trichrome_Staining_Method"                                                                                                                                            
[22357] "Elastin_Staining_Method"                                                                                                                                              
[22358] "Gram_Staining_Method"                                                                                                                                                 
[22359] "Acid_Fast_Bacillae_Staining_Method"                                                                                                                                   
[22360] "Iron_Staining_Method"                                                                                                                                                 
[22361] "Methyl_Green_Pyronine_Staining_Method"                                                                                                                                
[22362] "Silver_Staining_Method"                                                                                                                                               
[22363] "Periodic_Acid_Schiff_Staining_Method"                                                                                                                                 
[22364] "Immunohistochemistry_Staining_Method"                                                                                                                                 
[22365] "Smooth_Muscle_Actin_Staining_Method"                                                                                                                                  
[22366] "in_situ_Hybridization_Staining_Method"                                                                                                                                
[22367] "E-Cadherin_Staining_Method"                                                                                                                                           
[22368] "Beta_Catenin_Staining_Method"                                                                                                                                         
[22369] "Cytokeratin-14_Staining_Method"                                                                                                                                       
[22370] "Cytokeratin-8_Staining_Method"                                                                                                                                        
[22371] "Cytokeratin-18_Staining_Method"                                                                                                                                       
[22372] "Laminin_Staining_Method"                                                                                                                                              
[22373] "Synaptophysin_Staining_Method"                                                                                                                                        
[22374] "Whey_Acidic_Protein_Staining_Method"                                                                                                                                  
[22375] "Osteopontin_Staining_Method"                                                                                                                                          
[22376] "Mucin-1_Staining_Method"                                                                                                                                              
[22377] "Mucin-2_Staining_Method"                                                                                                                                              
[22378] "Polyoma_Virus_Middle_T_Staining_Method"                                                                                                                               
[22379] "c-Myc_Staining_Method"                                                                                                                                                
[22380] "Her2_erbb2_neu_Staining_Method"                                                                                                                                       
[22381] "Neu_Staining_Method"                                                                                                                                                  
[22382] "Staining_for_Viral_Inclusions"                                                                                                                                        
[22383] "Staining_of_Sputum_for_Pneumocystis"                                                                                                                                  
[22384] "Warthin-Starry_Staining_Method"                                                                                                                                       
[22385] "Wright-Giemsa_Staining_Method"                                                                                                                                        
[22386] "Diff-Quik_Staining_Method"                                                                                                                                            
[22387] "Routine_Histology_Staining_Method"                                                                                                                                    
[22388] "Special_Histology_Staining_Method"                                                                                                                                    
[22389] "Mouse_Head_and_Neck_Neoplasms"                                                                                                                                        
[22390] "Mouse_Oral_Cavity_Neoplasms"                                                                                                                                          
[22391] "Epithelial_Neoplasms_of_the_Mouse_Oral_Cavity"                                                                                                                        
[22392] "Carcinoma_of_the_Mouse_Oral_Cavity"                                                                                                                                   
[22393] "Squamous_Cell_Carcinoma_of_the_Mouse_Oral_Cavity"                                                                                                                     
[22394] "Squamous_Cell_Carcinoma_In-situ_of_the_Mouse_Oral_Cavity"                                                                                                             
[22395] "Verrucous_Carcinoma_of_the_Mouse_Oral_Cavity"                                                                                                                         
[22396] "Adenosquamous_Cell_Carcinoma_of_the_Mouse_Oral_Cavity"                                                                                                                
[22397] "Smooth_Muscle_Neoplasms_of_the_Mouse_Oral_Cavity"                                                                                                                     
[22398] "Leiomyoma_of_the_Mouse_Oral_Cavity"                                                                                                                                   
[22399] "Leiomyosarcoma_of_the_Mouse_Oral_Cavity"                                                                                                                              
[22400] "Neural_Neoplasms_of_the_Mouse_Oral_Cavity"                                                                                                                            
[22401] "Neurilemoma_of_the_Mouse_Oral_Cavity"                                                                                                                                 
[22402] "Neurofibroma_of_the_Mouse_Oral_Cavity"                                                                                                                                
[22403] "Synovial_Neoplasms_of_the_Mouse_Oral_Cavity"                                                                                                                          
[22404] "Synovial_Sarcoma_of_the_Mouse_Oral_Cavity"                                                                                                                            
[22405] "Melanocytic_Neoplasms_of_the_Mouse_Oral_Cavity"                                                                                                                       
[22406] "Melanoma_of_the_Mouse_Oral_Cavity"                                                                                                                                    
[22407] "Hematopoietic_Neoplasms_of_the_Mouse_Oral_Cavity"                                                                                                                     
[22408] "Lymphoproliferative_Neoplasms_of_the_Mouse_Oral_Cavity"                                                                                                               
[22409] "Lymphoma_of_the_Mouse_Oral_Cavity"                                                                                                                                    
[22410] "Plasma_Cell_Neoplasms_of_the_Mouse_Oral_Cavity"                                                                                                                       
[22411] "Plasmacytoma_of_the_Mouse_Oral_Cavity"                                                                                                                                
[22412] "Mouse_Pharyngeal_Neoplasms"                                                                                                                                           
[22413] "Epithelial_Neoplasms_of_the_Mouse_Pharynx"                                                                                                                            
[22414] "Squamous_Cell_Carcinoma_of_the_Mouse_Pharynx"                                                                                                                         
[22415] "Non-Keratinizing_Carcinoma_of_the_Mouse_Pharynx"                                                                                                                      
[22416] "Non-Keratinizing_Carcinoma_of_the_Mouse_Pharynx_Without_Lymphoid_Stroma"                                                                                              
[22417] "Non-Keratinizing_Carcinoma_of_the_Mouse_Pharynx_With_Lymphoid_Stroma"                                                                                                 
[22418] "Undifferentiated_Carcinoma_of_the_Mouse_Pharynx"                                                                                                                      
[22419] "Undifferentiated_Carcinoma_of_the_Mouse_Pharynx_Without_Lymphoid_Stroma"                                                                                              
[22420] "Undifferentiated_Carcinoma_of_the_Mouse_Pharynx_With_Lymphoid_Stroma"                                                                                                 
[22421] "Skeletal_Muscle_Neoplasms_of_the_Mouse_Pharynx"                                                                                                                       
[22422] "Embryonal_Rhabdomyosarcoma_of_the_Mouse_Pharynx"                                                                                                                      
[22423] "Synovial_Neoplasms_of_the_Mouse_Pharynx"                                                                                                                              
[22424] "Synovial_Sarcoma_of_the_Mouse_Pharynx"                                                                                                                                
[22425] "Vascular-fibrous_Neoplasms_of_the_Mouse_Pharynx"                                                                                                                      
[22426] "Angiofibroma_of_the_Mouse_Pharynx"                                                                                                                                    
[22427] "Hematopoietic_Neoplasms_of_the_Mouse_Pharynx"                                                                                                                         
[22428] "Lymphoproliferative_Neoplasms_of_the_Mouse_Pharynx"                                                                                                                   
[22429] "Lymphoma_of_the_Mouse_Pharynx"                                                                                                                                        
[22430] "Plasma_Cell_Neoplasms_of_the_Mouse_Pharynx"                                                                                                                           
[22431] "Plasmacytoma_of_the_Mouse_Pharynx"                                                                                                                                    
[22432] "Mouse_Nose_and_Paranasal_Sinuses_Neoplasms"                                                                                                                           
[22433] "Epithelial_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                         
[22434] "Papilloma_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                                    
[22435] "Carcinoma_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                                    
[22436] "Squamous_Cell_Carcinoma_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                      
[22437] "Verrucous_Carcinoma_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                          
[22438] "Adenocarcinoma_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                               
[22439] "Neural_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                             
[22440] "Olfactory_Neuroblastoma_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                      
[22441] "Melanocytic_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                        
[22442] "Melanoma_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                                     
[22443] "Hematopoietic_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                      
[22444] "Lymphoproliferative_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                
[22445] "Lymphoma_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                                     
[22446] "Angiocentric_Immunoproliferative_Lesion_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                      
[22447] "Plasma_Cell_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                        
[22448] "Plasmacytoma_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                                 
[22449] "Smooth_Muscle_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                      
[22450] "Leiomyosarcoma_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                               
[22451] "Skeletal_Muscle_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                    
[22452] "Embryonal_Rhabdomyosarcoma_of_the_Mouse_Nose_and_Paranasal_Sinuses"                                                                                                   
[22453] "Mouse_Laryngeal_Neoplasms"                                                                                                                                            
[22454] "Epithelial_Neoplasms_of_the_Mouse_Larynx"                                                                                                                             
[22455] "Papilloma_of_the_Mouse_Larynx"                                                                                                                                        
[22456] "Carcinoma_of_the_Mouse_Larynx"                                                                                                                                        
[22457] "Squamous_Cell_Carcinoma_of_the_Mouse_Larynx"                                                                                                                          
[22458] "Squamous_Cell_Carcinoma_In-situ_of_the_Mouse_Larynx"                                                                                                                  
[22459] "Adenoid_Cystic_Carcinoma_of_the_Mouse_Larynx"                                                                                                                         
[22460] "Mucoepidermoid_Carcinoma_of_the_Mouse_Larynx"                                                                                                                         
[22461] "Acinic_Cell_Carcinoma_of_the_Mouse_Larynx"                                                                                                                            
[22462] "Cartilage_Bone_Neoplasms_of_the_Mouse_Larynx"                                                                                                                         
[22463] "Chondrosarcoma_of_the_Mouse_Larynx"                                                                                                                                   
[22464] "Osteosarcoma_of_the_Mouse_Larynx"                                                                                                                                     
[22465] "Histiocytic_Neoplasms_of_the_Mouse_Larynx"                                                                                                                            
[22466] "Malignant_Fibrous_Histiocytoma_of_the_Mouse_Larynx"                                                                                                                   
[22467] "Neuroendocrine_Neoplasms_of_the_Mouse_Larynx"                                                                                                                         
[22468] "Carcinoid_Tumor_of_the_Mouse_Larynx"                                                                                                                                  
[22469] "Mouse_Salivary_Gland_Neoplasms"                                                                                                                                       
[22470] "Epithelial_Neoplasms_of_the_Mouse_Salivary_Glands"                                                                                                                    
[22471] "Adenoma_of_the_Mouse_Salivary_Glands"                                                                                                                                 
[22472] "Pleomorphic_Adenoma_of_the_Mouse_Salivary_Glands"                                                                                                                     
[22473] "Carcinoma_In_Pleomorphic_Adenoma_of_the_Mouse_Salivary_Glands"                                                                                                        
[22474] "Monomorphic_Adenoma_of_the_Mouse_Salivary_Glands"                                                                                                                     
[22475] "Oxyphilic_Adenoma_of_the_Mouse_Salivary_Glands"                                                                                                                       
[22476] "Warthin_s_Tumor_of_the_Mouse_Salivary_Glands"                                                                                                                         
[22477] "Basal_Cell_Adenoma_of_the_Mouse_Salivary_Glands"                                                                                                                      
[22478] "Clear_Cell_Adenoma_of_the_Mouse_Salivary_Glands"                                                                                                                      
[22479] "Sebaceous_Lymphadenoma_of_the_Mouse_Salivary_Glands"                                                                                                                  
[22480] "Myoepithelioma_of_the_Mouse_Salivary_Glands"                                                                                                                          
[22481] "Mucoepidermoid_Tumor_of_the_Mouse_Salivary_Glands"                                                                                                                    
[22482] "Low_Grade_Mucoepidermoid_Tumor_of_the_Mouse_Salivary_Glands"                                                                                                          
[22483] "High_Grade_Mucoepidermoid_Tumor_of_the_Mouse_Salivary_Glands"                                                                                                         
[22484] "Carcinoma_of_the_Mouse_Salivary_Glands"                                                                                                                               
[22485] "Acinic_Cell_Carcinoma_of_the_Mouse_Salivary_Glands"                                                                                                                   
[22486] "Adenoid_Cystic_Carcinoma_of_the_Mouse_Salivary_Glands"                                                                                                                
[22487] "Papillary_Adenocarcinoma_of_the_Mouse_Salivary_Glands"                                                                                                                
[22488] "Squamous_Cell_Carcinoma_of_the_Mouse_Salivary_Glands"                                                                                                                 
[22489] "Adenocarcinoma_of_the_Mouse_Salivary_Glands"                                                                                                                          
[22490] "Metastatic_Carcinoma_of_the_Mouse_Salivary_Glands"                                                                                                                    
[22491] "Hematopoietic_Neoplasms_of_the_Mouse_Salivary_Glands"                                                                                                                 
[22492] "Lymphoproliferative_Neoplasms_of_the_Mouse_Salivary_Glands"                                                                                                           
[22493] "Lymphoma_of_the_Mouse_Salivary_Glands"                                                                                                                                
[22494] "Plasma_Cell_Neoplasms_of_the_Mouse_Salivary_Glands"                                                                                                                   
[22495] "Plasmacytoma_of_the_Mouse_Salivary_Glands"                                                                                                                            
[22496] "Mouse_Anatomical_Concepts"                                                                                                                                            
[22497] "Mouse_Lip"                                                                                                                                                            
[22498] "Mouse_External_Upper_Lip"                                                                                                                                             
[22499] "Mouse_External_Lower_Lip"                                                                                                                                             
[22500] "Mouse_External_Lip_NOS"                                                                                                                                               
[22501] "Mouse_Mucosa_of_Upper_Lip"                                                                                                                                            
[22502] "Mouse_Mucosa_of_Lower_Lip"                                                                                                                                            
[22503] "Mouse_Mucosa_of_Lip_NOS"                                                                                                                                              
[22504] "Mouse_Commissure_of_Lip"                                                                                                                                              
[22505] "Mouse_Base_of_Tongue"                                                                                                                                                 
[22506] "Mouse_Palate"                                                                                                                                                         
[22507] "Mouse_Hard_Palate"                                                                                                                                                    
[22508] "Mouse_Soft_Palate"                                                                                                                                                    
[22509] "Mouse_Uvula"                                                                                                                                                          
[22510] "Mouse_Submandibular_Gland"                                                                                                                                            
[22511] "Mouse_Sublingual_Gland"                                                                                                                                               
[22512] "Mouse_Tonsillar_Fossa"                                                                                                                                                
[22513] "Mouse_Tonsillar_Pillar"                                                                                                                                               
[22514] "Mouse_Vallecula"                                                                                                                                                      
[22515] "Mouse_Anterior_Surface_of_Epiglottis"                                                                                                                                 
[22516] "Mouse_Lateral_Wall_of_Oropharynx"                                                                                                                                     
[22517] "Mouse_Posterior_Wall_of_Oropharynx"                                                                                                                                   
[22518] "Mouse_Branchial_Cleft"                                                                                                                                                
[22519] "Mouse_Superior_Wall_of_Nasopharynx"                                                                                                                                   
[22520] "Mouse_Posterior_Wall_of_Nasopharynx"                                                                                                                                  
[22521] "Mouse_Lateral_Wall_of_Nasopharynx"                                                                                                                                    
[22522] "Mouse_Anterior_Wall_of_Nasopharynx"                                                                                                                                   
[22523] "Mouse_Hypopharynx"                                                                                                                                                    
[22524] "Mouse_Postcricoid_Region"                                                                                                                                             
[22525] "Mouse_Hypopharyngeal_Aspect_of_Aryepiglottic_Fold"                                                                                                                    
[22526] "Mouse_Posterior_Wall_of_Hypopharynx"                                                                                                                                  
[22527] "Mouse_Cervical_Esophagus"                                                                                                                                             
[22528] "Mouse_Thoracic_Esophagus"                                                                                                                                             
[22529] "Mouse_Abdominal_Esophagus"                                                                                                                                            
[22530] "Mouse_Upper_Third_of_Esophagus"                                                                                                                                       
[22531] "Mouse_Middle_Third_of_Esophagus"                                                                                                                                      
[22532] "Mouse_Lower_Third_of_Esophagus"                                                                                                                                       
[22533] "Mouse_Cardia_NOS_Gastric_Cardia"                                                                                                                                      
[22534] "Mouse_Fundus_of_Stomach"                                                                                                                                              
[22535] "Mouse_Body_of_Stomach"                                                                                                                                                
[22536] "Mouse_Gastric_Antrum"                                                                                                                                                 
[22537] "Mouse_Pylorus"                                                                                                                                                        
[22538] "Mouse_Lesser_Curvature_of_Stomach_NOS"                                                                                                                                
[22539] "Mouse_Greater_Curvature_of_Stomach_NOS"                                                                                                                               
[22540] "Mouse_Duodenum"                                                                                                                                                       
[22541] "Mouse_Meckel_Diverticulum"                                                                                                                                            
[22542] "Mouse_Ascending_Colon"                                                                                                                                                
[22543] "Mouse_Hepatic_Flexure_of_Colon"                                                                                                                                       
[22544] "Mouse_Splenic_Flexure_of_Colon"                                                                                                                                       
[22545] "Mouse_Descending_Colon"                                                                                                                                               
[22546] "Mouse_Head_of_Pancreas"                                                                                                                                               
[22547] "Mouse_Body_of_Pancreas"                                                                                                                                               
[22548] "Mouse_Tail_of_Pancreas"                                                                                                                                               
[22549] "Mouse_Pancreatic_Duct"                                                                                                                                                
[22550] "Mouse_Other_Specified_Parts_of_Pancreas"                                                                                                                              
[22551] "Mouse_Middle_Ear"                                                                                                                                                     
[22552] "Mouse_Maxillary_Sinus"                                                                                                                                                
[22553] "Mouse_Ethmoid_Sinus"                                                                                                                                                  
[22554] "Mouse_Frontal_Sinus"                                                                                                                                                  
[22555] "Mouse_Sphenoid_Sinus"                                                                                                                                                 
[22556] "Mouse_Supraglottis"                                                                                                                                                   
[22557] "Mouse_Subglottis"                                                                                                                                                     
[22558] "Mouse_Laryngeal_Cartilage"                                                                                                                                            
[22559] "Mouse_Trachea_Proper"                                                                                                                                                 
[22560] "Mouse_Lung_and_Bronchus"                                                                                                                                              
[22561] "Mouse_Main_Bronchus"                                                                                                                                                  
[22562] "Mouse_Upper_Lobe_Lung"                                                                                                                                                
[22563] "Mouse_Right_Middle_Lobe_Lung"                                                                                                                                         
[22564] "Mouse_Lower_Lobe_Lung"                                                                                                                                                
[22565] "Mouse_Thymus_Proper"                                                                                                                                                  
[22566] "Mouse_Bones_of_Skull_and_Face_and_Associated_Joints"                                                                                                                  
[22567] "Mouse_Mandible"                                                                                                                                                       
[22568] "Mouse_Skin_of_Lip_NOS"                                                                                                                                                
[22569] "Mouse_External_Ear"                                                                                                                                                   
[22570] "Mouse_Skin_of_Other_and_Unspecified_Parts_of_Face"                                                                                                                    
[22571] "Mouse_Skin_of_Scalp_and_Neck"                                                                                                                                         
[22572] "Mouse_Skin_of_Trunk"                                                                                                                                                  
[22573] "Mouse_Skin_of_Upper_Limb_and_Shoulder"                                                                                                                                
[22574] "Mouse_Skin_of_Lower_Limb_and_Hip"                                                                                                                                     
[22575] "Mouse_Retroperitoneum"                                                                                                                                                
[22576] "Mouse_Nipple"                                                                                                                                                         
[22577] "Mouse_Central_Portion_of_Breast"                                                                                                                                      
[22578] "Mouse_Upper-inner_Quadrant_of_Breast"                                                                                                                                 
[22579] "Mouse_Lower-inner_Quadrant_of_Breast"                                                                                                                                 
[22580] "Mouse_Upper-outer_Quadrant_of_Breast"                                                                                                                                 
[22581] "Mouse_Lower-outer_Quadrant_of_Breast"                                                                                                                                 
[22582] "Mouse_Axillary_Tail_of_Breast"                                                                                                                                        
[22583] "Mouse_Female_Genital_Organs"                                                                                                                                          
[22584] "Mouse_Labium_Majus"                                                                                                                                                   
[22585] "Mouse_Labium_Minus"                                                                                                                                                   
[22586] "Mouse_Clitoris"                                                                                                                                                       
[22587] "Mouse_Endocervix"                                                                                                                                                     
[22588] "Mouse_Exocervix"                                                                                                                                                      
[22589] "Mouse_Cervix_Uteri"                                                                                                                                                   
[22590] "Mouse_Isthmus_Uteri"                                                                                                                                                  
[22591] "Mouse_Endometrium"                                                                                                                                                    
[22592] "Mouse_Myometrium"                                                                                                                                                     
[22593] "Mouse_Fundus_Uteri"                                                                                                                                                   
[22594] "Mouse_Corpus_Uteri"                                                                                                                                                   
[22595] "Mouse_Other_and_Unspecified_Female_Genital_Organs"                                                                                                                    
[22596] "Mouse_Broad_Ligament"                                                                                                                                                 
[22597] "Mouse_Round_Ligament"                                                                                                                                                 
[22598] "Mouse_Parametrium"                                                                                                                                                    
[22599] "Mouse_Uterine_Adnexa"                                                                                                                                                 
[22600] "Mouse_Other_Specified_Parts_of_Female_Genital_Organs"                                                                                                                 
[22601] "Mouse_Male_Genital_Organs"                                                                                                                                            
[22602] "Mouse_Prepuce"                                                                                                                                                        
[22603] "Mouse_Glans_Penis"                                                                                                                                                    
[22604] "Mouse_Body_of_Penis"                                                                                                                                                  
[22605] "Mouse_Undescended_Testis"                                                                                                                                             
[22606] "Mouse_Descended_Testis"                                                                                                                                               
[22607] "Mouse_Epididymis"                                                                                                                                                     
[22608] "Mouse_Spermatic_Cord"                                                                                                                                                 
[22609] "Mouse_Other_Specified_Parts_of_Male_Genital_Organs"                                                                                                                   
[22610] "Mouse_Trigone_of_Bladder"                                                                                                                                             
[22611] "Mouse_Dome_of_Bladder"                                                                                                                                                
[22612] "Mouse_Lateral_Wall_of_Bladder"                                                                                                                                        
[22613] "Mouse_Anterior_Wall_of_Bladder"                                                                                                                                       
[22614] "Mouse_Posterior_Wall_of_Bladder"                                                                                                                                      
[22615] "Mouse_Bladder_Neck"                                                                                                                                                   
[22616] "Mouse_Ureteric_Orifice"                                                                                                                                               
[22617] "Mouse_Urachus"                                                                                                                                                        
[22618] "Mouse_Paraurethral_Gland"                                                                                                                                             
[22619] "Mouse_Eye_and_Adnexa"                                                                                                                                                 
[22620] "Mouse_Conjunctiva"                                                                                                                                                    
[22621] "Mouse_Cornea"                                                                                                                                                         
[22622] "Mouse_Retina"                                                                                                                                                         
[22623] "Mouse_Choroid"                                                                                                                                                        
[22624] "Mouse_Ciliary_Body"                                                                                                                                                   
[22625] "Mouse_Lacrimal_Gland"                                                                                                                                                 
[22626] "Mouse_Orbit"                                                                                                                                                          
[22627] "Mouse_Meninges"                                                                                                                                                       
[22628] "Mouse_Cerebral_Meninges"                                                                                                                                              
[22629] "Mouse_Spinal_Meninges"                                                                                                                                                
[22630] "Mouse_Cerebral_Hemispheres"                                                                                                                                           
[22631] "Mouse_Frontal_Lobe"                                                                                                                                                   
[22632] "Mouse_Temporal_Lobe"                                                                                                                                                  
[22633] "Mouse_Parietal_Lobe"                                                                                                                                                  
[22634] "Mouse_Occipital_Lobe"                                                                                                                                                 
[22635] "Mouse_Ventricles_Brain"                                                                                                                                               
[22636] "Mouse_Craniopharyngeal_Duct"                                                                                                                                          
[22637] "Mouse_Lymph_Nodes_of_Head_Face_and_Neck"                                                                                                                              
[22638] "Mouse_Intrathoracic_Lymph_Nodes"                                                                                                                                      
[22639] "Mouse_Intra-abdominal_Lymph_Nodes"                                                                                                                                    
[22640] "Mouse_Lymph_Nodes_of_Axilla_or_Arm"                                                                                                                                   
[22641] "Mouse_Lymph_Nodes_of_Inguinal_Region_or_Leg"                                                                                                                          
[22642] "Mouse_Pelvic_Lymph_Nodes"                                                                                                                                             
[22643] "Mouse_Lymph_Nodes_of_Multiple_Regions"                                                                                                                                
[22644] "Mouse_Amnion"                                                                                                                                                         
[22645] "Mouse_Bones"                                                                                                                                                          
[22646] "Mouse_Mammary_Gland"                                                                                                                                                  
[22647] "Mouse_Areola"                                                                                                                                                         
[22648] "Mouse_Mammary_Gland_Fat-pad"                                                                                                                                          
[22649] "Mouse_Mammary_Gland_Parenchyma"                                                                                                                                       
[22650] "Mouse_Myocardium"                                                                                                                                                     
[22651] "Mouse_Artery"                                                                                                                                                         
[22652] "Mouse_Cartilage"                                                                                                                                                      
[22653] "Mouse_Connective_Tissue"                                                                                                                                              
[22654] "Mouse_Anus"                                                                                                                                                           
[22655] "Mouse_Bile_Duct"                                                                                                                                                      
[22656] "Mouse_Gall_Bladder"                                                                                                                                                   
[22657] "Mouse_Gastrointestinal_System"                                                                                                                                        
[22658] "Mouse_Large_Intestine"                                                                                                                                                
[22659] "Mouse_Appendix"                                                                                                                                                       
[22660] "Mouse_Cecum"                                                                                                                                                          
[22661] "Mouse_Colon"                                                                                                                                                          
[22662] "Mouse_Right_Colon"                                                                                                                                                    
[22663] "Mouse_Sigmoid_Colon"                                                                                                                                                  
[22664] "Mouse_Transverse_Colon"                                                                                                                                               
[22665] "Mouse_Small_Intestine"                                                                                                                                                
[22666] "Mouse_Ileum"                                                                                                                                                          
[22667] "Mouse_Jejunum"                                                                                                                                                        
[22668] "Mouse_Esophagus"                                                                                                                                                      
[22669] "Mouse_Rectum"                                                                                                                                                         
[22670] "Mouse_Stomach"                                                                                                                                                        
[22671] "Mouse_Liver"                                                                                                                                                          
[22672] "Mouse_Pancreas"                                                                                                                                                       
[22673] "Mouse_Ear"                                                                                                                                                            
[22674] "Mouse_Cochlea"                                                                                                                                                        
[22675] "Mouse_Adrenal_Cortex"                                                                                                                                                 
[22676] "Mouse_Adrenal_Medulla"                                                                                                                                                
[22677] "Mouse_Pineal_Gland"                                                                                                                                                   
[22678] "Mouse_Pituitary_Gland"                                                                                                                                                
[22679] "Mouse_Thyroid"                                                                                                                                                        
[22680] "Mouse_Eye"                                                                                                                                                            
[22681] "Mouse_Female_Reproductive_System"                                                                                                                                     
[22682] "Mouse_Fallopian_Tube"                                                                                                                                                 
[22683] "Mouse_Ovary"                                                                                                                                                          
[22684] "Mouse_Uterus"                                                                                                                                                         
[22685] "Mouse_Pregnant_Uterus"                                                                                                                                                
[22686] "Mouse_Vagina"                                                                                                                                                         
[22687] "Mouse_Vulva"                                                                                                                                                          
[22688] "Mouse_Penis"                                                                                                                                                          
[22689] "Mouse_Prostate_MF"                                                                                                                                                    
[22690] "Mouse_Testes"                                                                                                                                                         
[22691] "Mouse_Urinary_System"                                                                                                                                                 
[22692] "Mouse_Bladder"                                                                                                                                                        
[22693] "Mouse_Kidney"                                                                                                                                                         
[22694] "Mouse_Ureter"                                                                                                                                                         
[22695] "Mouse_Urethra"                                                                                                                                                        
[22696] "Mouse_Head_and_Neck"                                                                                                                                                  
[22697] "Mouse_Head"                                                                                                                                                           
[22698] "Mouse_Larynx"                                                                                                                                                         
[22699] "Mouse_Mouth"                                                                                                                                                          
[22700] "Mouse_Tongue"                                                                                                                                                         
[22701] "Mouse_Nasopharynx"                                                                                                                                                    
[22702] "Mouse_Nasal_Cavity"                                                                                                                                                   
[22703] "Mouse_Pharynx"                                                                                                                                                        
[22704] "Mouse_Salivary_Glands"                                                                                                                                                
[22705] "Mouse_Parotid"                                                                                                                                                        
[22706] "Mouse_Trachea"                                                                                                                                                        
[22707] "Mouse_Limb"                                                                                                                                                           
[22708] "Mouse_Lymphoreticular_Tissue"                                                                                                                                         
[22709] "Mouse_Bone_Marrow"                                                                                                                                                    
[22710] "Mouse_Spleen"                                                                                                                                                         
[22711] "Mouse_Thymus_Gland"                                                                                                                                                   
[22712] "Mouse_Blood"                                                                                                                                                          
[22713] "Mouse_Muscle_Tissue"                                                                                                                                                  
[22714] "Mouse_Striated_Muscle"                                                                                                                                                
[22715] "Mouse_Smooth_Muscle"                                                                                                                                                  
[22716] "Mouse_Central_Nervous_System"                                                                                                                                         
[22717] "Mouse_Brain"                                                                                                                                                          
[22718] "Mouse_Amygdala"                                                                                                                                                       
[22719] "Mouse_Brain_Stem"                                                                                                                                                     
[22720] "Mouse_Medulla_Oblongata"                                                                                                                                              
[22721] "Mouse_Cortex"                                                                                                                                                         
[22722] "Mouse_Hippocampus"                                                                                                                                                    
[22723] "Mouse_Cerebellum"                                                                                                                                                     
[22724] "Mouse_Corpus_Callosum"                                                                                                                                                
[22725] "Mouse_Basal_Ganglia"                                                                                                                                                  
[22726] "Mouse_Corpus_Striatum"                                                                                                                                                
[22727] "Mouse_Globus_Pallidus"                                                                                                                                                
[22728] "Mouse_Striatum"                                                                                                                                                       
[22729] "Mouse_Caudate_Nucleus"                                                                                                                                                
[22730] "Mouse_Putamen"                                                                                                                                                        
[22731] "Mouse_Substantia_Nigra"                                                                                                                                               
[22732] "Mouse_Subthalamic_Nucleus"                                                                                                                                            
[22733] "Mouse_Prosencephalon"                                                                                                                                                 
[22734] "Mouse_Diencephalon"                                                                                                                                                   
[22735] "Mouse_Epithalamus"                                                                                                                                                    
[22736] "Mouse_Hypothalamus"                                                                                                                                                   
[22737] "Mouse_Thalamus"                                                                                                                                                       
[22738] "Mouse_Tectum_Mesencephali"                                                                                                                                            
[22739] "Mouse_Corpora_Quadrigemina"                                                                                                                                           
[22740] "Mouse_Dorsal_Root_Ganglion"                                                                                                                                           
[22741] "Mouse_Notochord"                                                                                                                                                      
[22742] "Mouse_Spinal_Cord"                                                                                                                                                    
[22743] "Mouse_Peripheral_Nervous_System"                                                                                                                                      
[22744] "Mouse_Nerve"                                                                                                                                                          
[22745] "Mouse_Sympathetic_Ganglion"                                                                                                                                           
[22746] "Mouse_Lung"                                                                                                                                                           
[22747] "Mouse_Pleura"                                                                                                                                                         
[22748] "Mouse_Skin"                                                                                                                                                           
[22749] "Mouse_Soft_Tissue"                                                                                                                                                    
[22750] "Mouse_Adipose_Tissue"                                                                                                                                                 
[22751] "Mouse_Synovium"                                                                                                                                                       
[22752] "Mouse_B-Lymphocytes"                                                                                                                                                  
[22753] "Mouse_Basal_Cells"                                                                                                                                                    
[22754] "Mouse_T-Lymphocytes"                                                                                                                                                  
[22755] "Mouse_Astrocytes"                                                                                                                                                     
[22756] "Mouse_Clear_Cells"                                                                                                                                                    
[22757] "Mouse_Ductal_Cells"                                                                                                                                                   
[22758] "Mouse_Terminal_Ductal_Lobular_Units"                                                                                                                                  
[22759] "Mouse_Endothelium"                                                                                                                                                    
[22760] "Mouse_Fibroblasts"                                                                                                                                                    
[22761] "Mouse_Granular_Cell"                                                                                                                                                  
[22762] "Mouse_Large_Cell"                                                                                                                                                     
[22763] "Mouse_Neuroendocrine_Cells"                                                                                                                                           
[22764] "Mouse_Plasma_Cells"                                                                                                                                                   
[22765] "Mouse_Signet_Ring_Cells"                                                                                                                                              
[22766] "Mouse_Small_Cells"                                                                                                                                                    
[22767] "Mouse_Spindle_Cell"                                                                                                                                                   
[22768] "Mouse_Stroma"                                                                                                                                                         
[22769] "Mouse_Intrathoracal"                                                                                                                                                  
[22770] "Mouse_Intraabdominal"                                                                                                                                                 
[22771] "Mouse_Base_of_Skull"                                                                                                                                                  
[22772] "Mouse_Clivus"                                                                                                                                                         
[22773] "Mouse_Foramen_Magnum"                                                                                                                                                 
[22774] "Mouse_Jugular_Foramen"                                                                                                                                                
[22775] "Mouse_Sella_Turcica"                                                                                                                                                  
[22776] "Mouse_External_Auditory_Canal"                                                                                                                                        
[22777] "Mouse_Inner_Ear"                                                                                                                                                      
[22778] "Mouse_Eustachian_Tube"                                                                                                                                                
[22779] "Mouse_Internal_Auditory_Canal"                                                                                                                                        
[22780] "Mouse_Tympanic_Membrane"                                                                                                                                              
[22781] "Mouse_Mastoid"                                                                                                                                                        
[22782] "Mouse_Buccal_Cavity"                                                                                                                                                  
[22783] "Mouse_Buccal_Mucosa"                                                                                                                                                  
[22784] "Mouse_Tooth"                                                                                                                                                          
[22785] "Mouse_Mantle_Field"                                                                                                                                                   
[22786] "Mouse_Cell_Types"                                                                                                                                                     
[22787] "Mouse_Infratentorial_Brain"                                                                                                                                           
[22788] "Mouse_Midbrain"                                                                                                                                                       
[22789] "Mouse_Pons"                                                                                                                                                           
[22790] "Mouse_Supratentorial_Brain"                                                                                                                                           
[22791] "Mouse_Sagittal_Sinus"                                                                                                                                                 
[22792] "Mouse_Inferior_Sagittal_Sinus"                                                                                                                                        
[22793] "Mouse_Superior_Sagittal_Sinus"                                                                                                                                        
[22794] "Mouse_Intracranial_Nervous_System"                                                                                                                                    
[22795] "Mouse_Intraspinal_Nervous_System"                                                                                                                                     
[22796] "Mouse_Blastomeres"                                                                                                                                                    
[22797] "Mouse_Blood_Cells"                                                                                                                                                    
[22798] "Mouse_Blood_Platelets"                                                                                                                                                
[22799] "Mouse_Erythrocytes"                                                                                                                                                   
[22800] "Mouse_Abnormal_Red_Blood_Cell"                                                                                                                                        
[22801] "Mouse_Acanthocytes"                                                                                                                                                   
[22802] "Mouse_Megaloblasts"                                                                                                                                                   
[22803] "Mouse_Spherocytes"                                                                                                                                                    
[22804] "Mouse_Erythroid_Progenitor_Cells"                                                                                                                                     
[22805] "Mouse_Erythroblasts"                                                                                                                                                  
[22806] "Mouse_Reticulocytes"                                                                                                                                                  
[22807] "Mouse_Leukocytes"                                                                                                                                                     
[22808] "Mouse_Granulocytes"                                                                                                                                                   
[22809] "Mouse_Basophils"                                                                                                                                                      
[22810] "Mouse_Eosinophils"                                                                                                                                                    
[22811] "Mouse_Neutrophils"                                                                                                                                                    
[22812] "Mouse_Leukocytes_Mononuclear"                                                                                                                                         
[22813] "Mouse_Lymphocytes"                                                                                                                                                    
[22814] "Mouse_Killer_Cells"                                                                                                                                                   
[22815] "Mouse_CD4-Positive_T-Lymphocytes"                                                                                                                                     
[22816] "Mouse_T-Lymphocytes_Helper-Inducer"                                                                                                                                   
[22817] "Mouse_Th1_Cells"                                                                                                                                                      
[22818] "Mouse_Th2_Cells"                                                                                                                                                      
[22819] "Mouse_T-Lymphocytes_Suppressor-Inducer"                                                                                                                               
[22820] "Mouse_CD8-Positive_T-Lymphocytes"                                                                                                                                     
[22821] "Mouse_T-Lymphocytes_Cytotoxic"                                                                                                                                        
[22822] "Mouse_T-Lymphocytes_Suppressor-Effector"                                                                                                                              
[22823] "Mouse_Lymphocytes_Null"                                                                                                                                               
[22824] "Mouse_Lymphocytes_Tumor-Infiltrating"                                                                                                                                 
[22825] "Mouse_Monocytes"                                                                                                                                                      
[22826] "Mouse_Monocytes_Activated_Killer"                                                                                                                                     
[22827] "Mouse_Myeloid_Cells"                                                                                                                                                  
[22828] "Mouse_Bone_Marrow_Blood-Forming_Cells"                                                                                                                                
[22829] "Mouse_Hematopoietic_Stem_Cells"                                                                                                                                       
[22830] "Mouse_Myeloid_Progenitor_Cells"                                                                                                                                       
[22831] "Mouse_Megakaryocytes"                                                                                                                                                 
[22832] "Mouse_Chromaffin_Cells"                                                                                                                                               
[22833] "Mouse_Connective_Tissue_Cells"                                                                                                                                        
[22834] "Mouse_Adipocytes"                                                                                                                                                     
[22835] "Mouse_Chondrocytes"                                                                                                                                                   
[22836] "Mouse_Macrophages"                                                                                                                                                    
[22837] "Mouse_Epithelioid_Cells"                                                                                                                                              
[22838] "Mouse_Foam_Cells"                                                                                                                                                     
[22839] "Mouse_Giant_Cells_Foreign-Body"                                                                                                                                       
[22840] "Mouse_Giant_Cells_Langhans"                                                                                                                                           
[22841] "Mouse_Histiocytes"                                                                                                                                                    
[22842] "Mouse_Kupffer_Cells"                                                                                                                                                  
[22843] "Mouse_Alveolar_Macrophage"                                                                                                                                            
[22844] "Mouse_Peritoneal_Macrophages"                                                                                                                                         
[22845] "Mouse_Odontoblasts"                                                                                                                                                   
[22846] "Mouse_Osteoblasts"                                                                                                                                                    
[22847] "Mouse_Osteocytes"                                                                                                                                                     
[22848] "Mouse_Osteoclasts"                                                                                                                                                    
[22849] "Mouse_Stromal_Cells"                                                                                                                                                  
[22850] "Mouse_Theca_Cells"                                                                                                                                                    
[22851] "Mouse_Endocrine_Cells_of_Gut"                                                                                                                                         
[22852] "Mouse_D_Cells"                                                                                                                                                        
[22853] "Mouse_Enterochromaffin_Cells"                                                                                                                                         
[22854] "Mouse_Enterochromaffin-like_Cells"                                                                                                                                    
[22855] "Mouse_G_Cells"                                                                                                                                                        
[22856] "Mouse_Epithelial_Cells"                                                                                                                                               
[22857] "Mouse_Ameloblasts"                                                                                                                                                    
[22858] "Mouse_Chief_Cells_Gastric"                                                                                                                                            
[22859] "Mouse_Chromatophores"                                                                                                                                                 
[22860] "Mouse_Melanophores"                                                                                                                                                   
[22861] "Mouse_Dendritic_Cell"                                                                                                                                                 
[22862] "Mouse_Langerhans_Cells"                                                                                                                                               
[22863] "Mouse_Enterocytes"                                                                                                                                                    
[22864] "Mouse_Goblet_Cells"                                                                                                                                                   
[22865] "Mouse_Granulosa_Cells"                                                                                                                                                
[22866] "Mouse_Hepatocytes"                                                                                                                                                    
[22867] "Mouse_Keratinocytes"                                                                                                                                                  
[22868] "Mouse_Labyrinth_Supporting_Cells"                                                                                                                                     
[22869] "Mouse_Melanocytes"                                                                                                                                                    
[22870] "Mouse_Merkel_Cells"                                                                                                                                                   
[22871] "Mouse_Paneth_Cells"                                                                                                                                                   
[22872] "Mouse_Parietal_Cells_Gastric"                                                                                                                                         
[22873] "Mouse_Sertoli_Cells"                                                                                                                                                  
[22874] "Mouse_Eukaryotic_Cells"                                                                                                                                               
[22875] "Mouse_Germ_Cells"                                                                                                                                                     
[22876] "Mouse_Ovum"                                                                                                                                                           
[22877] "Mouse_Oocytes"                                                                                                                                                        
[22878] "Mouse_Oogonia"                                                                                                                                                        
[22879] "Mouse_Zygote"                                                                                                                                                         
[22880] "Mouse_Spermatozoa"                                                                                                                                                    
[22881] "Mouse_Sperm_Head"                                                                                                                                                     
[22882] "Mouse_Spermatids"                                                                                                                                                     
[22883] "Mouse_Spermatocytes"                                                                                                                                                  
[22884] "Mouse_Spermatogonia"                                                                                                                                                  
[22885] "Mouse_Giant_Cells"                                                                                                                                                    
[22886] "Mouse_Islets_of_Langerhans"                                                                                                                                           
[22887] "Mouse_Leydig_Cells"                                                                                                                                                   
[22888] "Mouse_Lutein_Cells"                                                                                                                                                   
[22889] "Mouse_Antibody-Producing_Cells"                                                                                                                                       
[22890] "Mouse_Muscle_Cells"                                                                                                                                                   
[22891] "Mouse_Muscle_Fibers_Fast-Twitch"                                                                                                                                      
[22892] "Mouse_Muscle_Fibers_Slow-Twitch"                                                                                                                                      
[22893] "Mouse_Neuroglia"                                                                                                                                                      
[22894] "Mouse_Microglia"                                                                                                                                                      
[22895] "Mouse_Neuropil"                                                                                                                                                       
[22896] "Mouse_Oligodendroglia"                                                                                                                                                
[22897] "Mouse_Perineuronal_Satellite_Cell"                                                                                                                                    
[22898] "Mouse_Schwann_Cells"                                                                                                                                                  
[22899] "Mouse_Antigen-Presenting_Cells"                                                                                                                                       
[22900] "Mouse_Follicular_Dendritic_Cells"                                                                                                                                     
[22901] "Mouse_Neurons"                                                                                                                                                        
[22902] "Mouse_Autonomic_Fibers_Preganglionic"                                                                                                                                 
[22903] "Mouse_Interneurons"                                                                                                                                                   
[22904] "Mouse_Amacrine_Cells"                                                                                                                                                 
[22905] "Mouse_Nerve_Fibers_Myelinated"                                                                                                                                        
[22906] "Mouse_Neurons_Afferent"                                                                                                                                               
[22907] "Mouse_Hair_Cells"                                                                                                                                                     
[22908] "Mouse_Hair_Cells_Inner"                                                                                                                                               
[22909] "Mouse_Hair_Cells_Outer"                                                                                                                                               
[22910] "Mouse_Hair_Cells_Vestibular"                                                                                                                                          
[22911] "Mouse_Olfactory_Receptor_Neurons"                                                                                                                                     
[22912] "Mouse_Photoreceptors"                                                                                                                                                 
[22913] "Mouse_Photoreceptors_Invertebrate"                                                                                                                                    
[22914] "Mouse_Photoreceptors_Vertebrate"                                                                                                                                      
[22915] "Mouse_Cones_Retina"                                                                                                                                                   
[22916] "Mouse_Rods_Retina"                                                                                                                                                    
[22917] "Mouse_Rod_Outer_Segments"                                                                                                                                             
[22918] "Mouse_Posterior_Horn_Cells"                                                                                                                                           
[22919] "Mouse_Substantia_Gelatinosa"                                                                                                                                          
[22920] "Mouse_Retinal_Ganglion_Cells"                                                                                                                                         
[22921] "Mouse_Neurons_Efferent"                                                                                                                                               
[22922] "Mouse_Motor_Neurons"                                                                                                                                                  
[22923] "Mouse_Anterior_Horn_Cells"                                                                                                                                            
[22924] "Mouse_Motor_Neurons_Gamma"                                                                                                                                            
[22925] "Mouse_Nitrergic_Neurons"                                                                                                                                              
[22926] "Mouse_Autonomic_Fibers_Postganglionic"                                                                                                                                
[22927] "Mouse_Parasympathetic_Fibers_Postganglionic"                                                                                                                          
[22928] "Mouse_Sympathetic_Fibers_Postganglionic"                                                                                                                              
[22929] "Mouse_Purkinje_Cells"                                                                                                                                                 
[22930] "Mouse_Pyramidal_Cells"                                                                                                                                                
[22931] "Mouse_Senile_Plaques"                                                                                                                                                 
[22932] "Mouse_Oxyphil_Cells"                                                                                                                                                  
[22933] "Mouse_APUD_Cells"                                                                                                                                                     
[22934] "Mouse_Pericytes"                                                                                                                                                      
[22935] "Mouse_Phagocytes"                                                                                                                                                     
[22936] "Mouse_Reed-Sternberg_Cells"                                                                                                                                           
[22937] "Mouse_Stem_Cells"                                                                                                                                                     
[22938] "Mouse_Tumor_Stem_Cells"                                                                                                                                               
[22939] "Mouse_Abdomen"                                                                                                                                                        
[22940] "Mouse_Abducens_Nerve"                                                                                                                                                 
[22941] "Mouse_Adrenal_Gland"                                                                                                                                                  
[22942] "Mouse_Anterior_Chamber_of_Eye"                                                                                                                                        
[22943] "Mouse_Anterior_Eye_Segment"                                                                                                                                           
[22944] "Mouse_Aorta"                                                                                                                                                          
[22945] "Mouse_Aortic_Valve"                                                                                                                                                   
[22946] "Mouse_Upper_Extremity"                                                                                                                                                
[22947] "Mouse_Arteriole"                                                                                                                                                      
[22948] "Mouse_Autonomic_Nervous_System"                                                                                                                                       
[22949] "Mouse_Axilla"                                                                                                                                                         
[22950] "Mouse_Bartholin_s_Gland"                                                                                                                                              
[22951] "Mouse_Basilar_Artery"                                                                                                                                                 
[22952] "Mouse_Intrahepatic_Bile_Duct"                                                                                                                                         
[22953] "Mouse_Biliary_Tract"                                                                                                                                                  
[22954] "Mouse_Blood_Vessel"                                                                                                                                                   
[22955] "Mouse_Body_Region"                                                                                                                                                    
[22956] "Mouse_Brachial_Artery"                                                                                                                                                
[22957] "Mouse_Brachial_Plexus"                                                                                                                                                
[22958] "Mouse_Bronchus"                                                                                                                                                       
[22959] "Mouse_Bronchioles"                                                                                                                                                    
[22960] "Mouse_Capillary"                                                                                                                                                      
[22961] "Mouse_Cardiovascular_System"                                                                                                                                          
[22962] "Mouse_Carotid_Artery"                                                                                                                                                 
[22963] "Mouse_Carpal_Bone"                                                                                                                                                    
[22964] "Mouse_Cauda_Equina"                                                                                                                                                   
[22965] "Mouse_Cavernous_Sinus"                                                                                                                                                
[22966] "Mouse_Cerebral_Arteries"                                                                                                                                              
[22967] "Mouse_Cerebrospinal_Fluid"                                                                                                                                            
[22968] "Mouse_Cervical_Vertebrae"                                                                                                                                             
[22969] "Mouse_Choroid_Plexus"                                                                                                                                                 
[22970] "Mouse_Clavicle"                                                                                                                                                       
[22971] "Mouse_Coccyx"                                                                                                                                                         
[22972] "Mouse_Cochlear_Nerve"                                                                                                                                                 
[22973] "Mouse_Common_Bile_Duct"                                                                                                                                               
[22974] "Mouse_Corneal_Stroma"                                                                                                                                                 
[22975] "Mouse_Cranial_Nerve"                                                                                                                                                  
[22976] "Mouse_Dermis"                                                                                                                                                         
[22977] "Mouse_Diaphragm"                                                                                                                                                      
[22978] "Mouse_Ectoderm"                                                                                                                                                       
[22979] "Mouse_Endocrine_Gland"                                                                                                                                                
[22980] "Mouse_Endocrine_System"                                                                                                                                               
[22981] "Mouse_Endoderm"                                                                                                                                                       
[22982] "Mouse_Corneal_Endothelium"                                                                                                                                            
[22983] "Mouse_Epidermis"                                                                                                                                                      
[22984] "Mouse_Epiglottis"                                                                                                                                                     
[22985] "Mouse_Epithelium"                                                                                                                                                     
[22986] "Mouse_Ethmoid_Bone"                                                                                                                                                   
[22987] "Mouse_Exocrine_Gland"                                                                                                                                                 
[22988] "Mouse_Eyelid"                                                                                                                                                         
[22989] "Mouse_Facial_Nerve"                                                                                                                                                   
[22990] "Mouse_Femoral_Artery"                                                                                                                                                 
[22991] "Mouse_Femoral_Vein"                                                                                                                                                   
[22992] "Mouse_Femur"                                                                                                                                                          
[22993] "Mouse_Fibula"                                                                                                                                                         
[22994] "Mouse_Ganglia"                                                                                                                                                        
[22995] "Mouse_Autonomic_Ganglia"                                                                                                                                              
[22996] "Mouse_Geniculate_Ganglion"                                                                                                                                            
[22997] "Mouse_Male_Reproductive_System"                                                                                                                                       
[22998] "Mouse_Glossopharyngeal_Nerve"                                                                                                                                         
[22999] "Mouse_Glottis"                                                                                                                                                        
[23000] "Mouse_Gonads"                                                                                                                                                         
[23001] "Mouse_Groin"                                                                                                                                                          
[23002] "Mouse_Heart"                                                                                                                                                          
[23003] "Mouse_Cardiac_Atria"                                                                                                                                                  
[23004] "Mouse_Cardiac_Valves"                                                                                                                                                 
[23005] "Mouse_Cardiac_Ventricles"                                                                                                                                             
[23006] "Mouse_Humerus"                                                                                                                                                        
[23007] "Mouse_Hypoglossal_Nerve"                                                                                                                                              
[23008] "Mouse_Iliac_Artery"                                                                                                                                                   
[23009] "Mouse_Iliac_Vein"                                                                                                                                                     
[23010] "Mouse_Immune_System"                                                                                                                                                  
[23011] "Mouse_Intestines"                                                                                                                                                     
[23012] "Mouse_Iris"                                                                                                                                                           
[23013] "Mouse_Jugular_Vein"                                                                                                                                                   
[23014] "Mouse_Renal_Cortex"                                                                                                                                                   
[23015] "Mouse_Renal_Medulla"                                                                                                                                                  
[23016] "Mouse_Natural_Killer_Cells"                                                                                                                                           
[23017] "Mouse_Lower_Extremity"                                                                                                                                                
[23018] "Mouse_Lens"                                                                                                                                                           
[23019] "Mouse_Lumbar_Vertebrae"                                                                                                                                               
[23020] "Mouse_Lymph_Nodes"                                                                                                                                                    
[23021] "Mouse_Lymphatic_System"                                                                                                                                               
[23022] "Mouse_Mast_Cells"                                                                                                                                                     
[23023] "Mouse_Mediastinum"                                                                                                                                                    
[23024] "Mouse_Membrane"                                                                                                                                                       
[23025] "Mouse_Mesoderm"                                                                                                                                                       
[23026] "Mouse_Metacarpal_Bones"                                                                                                                                               
[23027] "Mouse_Metatarsal_Bones"                                                                                                                                               
[23028] "Mouse_Mitral_Valve"                                                                                                                                                   
[23029] "Mouse_Musculoskeletal_System"                                                                                                                                         
[23030] "Mouse_Nervous_System"                                                                                                                                                 
[23031] "Mouse_Nose"                                                                                                                                                           
[23032] "Mouse_Occipital_Bone"                                                                                                                                                 
[23033] "Mouse_Oculomotor_Nerve"                                                                                                                                               
[23034] "Mouse_Olfactory_Nerve"                                                                                                                                                
[23035] "Mouse_Optic_Disc"                                                                                                                                                     
[23036] "Mouse_Optic_Nerve"                                                                                                                                                    
[23037] "Mouse_Oropharynx"                                                                                                                                                     
[23038] "Mouse_Nasal_Sinuses"                                                                                                                                                  
[23039] "Mouse_Parasympathetic_Nervous_System"                                                                                                                                 
[23040] "Mouse_Parathyroid_Gland"                                                                                                                                              
[23041] "Mouse_Parietal_Bone"                                                                                                                                                  
[23042] "Mouse_Pelvis"                                                                                                                                                         
[23043] "Mouse_Peripheral_Nerves"                                                                                                                                              
[23044] "Mouse_Peritoneal_Cavity"                                                                                                                                              
[23045] "Mouse_Peritoneum"                                                                                                                                                     
[23046] "Mouse_Peyer_s_Patches"                                                                                                                                                
[23047] "Mouse_Anterior_Pituitary_Gland"                                                                                                                                       
[23048] "Mouse_Posterior_Pituitary_Gland"                                                                                                                                      
[23049] "Mouse_Pulmonary_Artery"                                                                                                                                               
[23050] "Mouse_Pulmonic_Valve"                                                                                                                                                 
[23051] "Mouse_Pulmonary_Vein"                                                                                                                                                 
[23052] "Mouse_Radius"                                                                                                                                                         
[23053] "Mouse_Renal_Artery"                                                                                                                                                   
[23054] "Mouse_Respiratory_System"                                                                                                                                             
[23055] "Mouse_Reticuloendothelial_System"                                                                                                                                     
[23056] "Mouse_Retroperitoneal_Space"                                                                                                                                          
[23057] "Mouse_Rib"                                                                                                                                                            
[23058] "Mouse_Scapula"                                                                                                                                                        
[23059] "Mouse_Sclera"                                                                                                                                                         
[23060] "Mouse_Scrotum"                                                                                                                                                        
[23061] "Mouse_Lunate_Bone"                                                                                                                                                    
[23062] "Mouse_Seminal_Vesicles"                                                                                                                                               
[23063] "Mouse_Skeletal_System"                                                                                                                                                
[23064] "Mouse_Skull"                                                                                                                                                          
[23065] "Mouse_Sphenoid_Bone"                                                                                                                                                  
[23066] "Mouse_Spinal_Nerve_Roots"                                                                                                                                             
[23067] "Mouse_Spinal_Nerves"                                                                                                                                                  
[23068] "Mouse_Sternum"                                                                                                                                                        
[23069] "Mouse_Subclavian_Vein"                                                                                                                                                
[23070] "Mouse_Sympathetic_Nervous_System"                                                                                                                                     
[23071] "Mouse_Tarsal_Bones"                                                                                                                                                   
[23072] "Mouse_Temporal_Bone"                                                                                                                                                  
[23073] "Mouse_Thoracic_Vertebrae"                                                                                                                                             
[23074] "Mouse_Thorax"                                                                                                                                                         
[23075] "Mouse_Tibia"                                                                                                                                                          
[23076] "Mouse_Tissue_Types"                                                                                                                                                   
[23077] "Mouse_Tonsils"                                                                                                                                                        
[23078] "Mouse_Trabecular_Meshwork"                                                                                                                                            
[23079] "Mouse_Transplanted_Bone_Marrow"                                                                                                                                       
[23080] "Mouse_Tricuspid_Valve"                                                                                                                                                
[23081] "Mouse_Trigeminal_Nerve"                                                                                                                                               
[23082] "Mouse_Trigeminal_Nuclei"                                                                                                                                              
[23083] "Mouse_Trochlear_Nerve"                                                                                                                                                
[23084] "Mouse_Ulna"                                                                                                                                                           
[23085] "Mouse_Genitourinary_System"                                                                                                                                           
[23086] "Mouse_Uveal_Tract"                                                                                                                                                    
[23087] "Mouse_Vagus_Nerve"                                                                                                                                                    
[23088] "Mouse_Vas_Deferens"                                                                                                                                                   
[23089] "Mouse_Vein"                                                                                                                                                           
[23090] "Mouse_Inferior_Vena_Cava"                                                                                                                                             
[23091] "Mouse_Superior_Vena_Cava"                                                                                                                                             
[23092] "Mouse_Vena_Cava"                                                                                                                                                      
[23093] "Mouse_Venule"                                                                                                                                                         
[23094] "Mouse_Vertebral_Artery"                                                                                                                                               
[23095] "Mouse_Vestibular_Nerve"                                                                                                                                               
[23096] "Mouse_Vestibular_Nuclei"                                                                                                                                              
[23097] "Mouse_Vocal_Cords"                                                                                                                                                    
[23098] "Mouse_Corneal_Limbus"                                                                                                                                                 
[23099] "Mouse_Tibial_Arteries"                                                                                                                                                
[23100] "Mouse_Anterior_Tibial_Artery"                                                                                                                                         
[23101] "Mouse_Posterior_Tibial_Artery"                                                                                                                                        
[23102] "Mouse_Third_Ventricle_of_Brain"                                                                                                                                       
[23103] "Mouse_Fourth_Ventricle_of_Brain"                                                                                                                                      
[23104] "Mouse_Anterior_Cerebral_Arteries"                                                                                                                                     
[23105] "Mouse_Middle_Cerebral_Arteries"                                                                                                                                       
[23106] "Mouse_Posterior_Cerebral_Arteries"                                                                                                                                    
[23107] "Mouse_Conus_Medullaris"                                                                                                                                               
[23108] "Mouse_Anterior_Spinal_Artery"                                                                                                                                         
[23109] "Mouse_Lateral_Ventricle_of_Brain"                                                                                                                                     
[23110] "Mouse_Nucleus_Ambiguus"                                                                                                                                               
[23111] "Mouse_Abducens_Nucleus"                                                                                                                                               
[23112] "Mouse_Cochlear_Nuclei"                                                                                                                                                
[23113] "Mouse_Radial_Artery"                                                                                                                                                  
[23114] "Mouse_Ulnar_Artery"                                                                                                                                                   
[23115] "Mouse_Pleural_Cavity"                                                                                                                                                 
[23116] "Mouse_Skin_Graft"                                                                                                                                                     
[23117] "Mouse_Coronary_Artery"                                                                                                                                                
[23118] "Mouse_Cervical_Neck_Region"                                                                                                                                           
[23119] "Mouse_Lumbar_Plexus"                                                                                                                                                  
[23120] "Mouse_Sacral_Plexus"                                                                                                                                                  
[23121] "Mouse_Reactive_Lymphocyte"                                                                                                                                            
[23122] "Mouse_Squamous_Epithelium"                                                                                                                                            
[23123] "Mouse_Squamous_Cells"                                                                                                                                                 
[23124] "Mouse_Stratum_Spinosum"                                                                                                                                               
[23125] "Mouse_Breast_Female"                                                                                                                                                  
[23126] "Mouse_Vertebral_Body"                                                                                                                                                 
[23127] "Mouse_Sacral_Vertebrae"                                                                                                                                               
[23128] "Mouse_Scaphoid_Bone"                                                                                                                                                  
[23129] "Mouse_Pisiform_Bone"                                                                                                                                                  
[23130] "Mouse_Capitate_Bone"                                                                                                                                                  
[23131] "Mouse_Trapezial_Bone"                                                                                                                                                 
[23132] "Mouse_Triangular_Bone"                                                                                                                                                
[23133] "Mouse_Trapezoid_Bone"                                                                                                                                                 
[23134] "Mouse_Hamate_Bone"                                                                                                                                                    
[23135] "Mouse_Phalanges_of_Hand"                                                                                                                                              
[23136] "Mouse_Proximal_Phalanx_of_Hand"                                                                                                                                       
[23137] "Mouse_Middle_Phalanx_of_Hand"                                                                                                                                         
[23138] "Mouse_Distal_Phalanx_of_Hand"                                                                                                                                         
[23139] "Mouse_Endothelial_Cells"                                                                                                                                              
[23140] "Mouse_Transitional_Cells"                                                                                                                                             
[23141] "Mouse_Alveolar_Epithelium"                                                                                                                                            
[23142] "Mouse_Right_Atrium"                                                                                                                                                   
[23143] "Mouse_Left_Atrium"                                                                                                                                                    
[23144] "Mouse_Right_Ventricle"                                                                                                                                                
[23145] "Mouse_Left_Ventricle"                                                                                                                                                 
[23146] "Mouse_Left_Coronary_Artery"                                                                                                                                           
[23147] "Mouse_Diagonal_Branch_of_Descending_Branch_of_Left_Coronary_Artery"                                                                                                   
[23148] "Mouse_Circumflex_Branch_of_Left_Coronary_Artery"                                                                                                                      
[23149] "Mouse_RIght_Coronary_Artery"                                                                                                                                          
[23150] "Mouse_Posterior_Spinal_Artery"                                                                                                                                        
[23151] "Mouse_Venous_Sinus"                                                                                                                                                   
[23152] "Mouse_Cardiac_Vein"                                                                                                                                                   
[23153] "Mouse_Great_Cardiac_Vein"                                                                                                                                             
[23154] "Mouse_Middle_Cardiac_Vein"                                                                                                                                            
[23155] "Mouse_Small_Cardiac_Vein"                                                                                                                                             
[23156] "Mouse_Coronary_Vein"                                                                                                                                                  
[23157] "Mouse_Brachial_Vein"                                                                                                                                                  
[23158] "Mouse_Urothelium"                                                                                                                                                     
[23159] "Mouse_Renal_Capsule"                                                                                                                                                  
[23160] "Mouse_Renal_Pyramid"                                                                                                                                                  
[23161] "Mouse_Renal_Pelvis"                                                                                                                                                   
[23162] "Mouse_Visual_System"                                                                                                                                                  
[23163] "Mouse_Auditory_System"                                                                                                                                                
[23164] "Mouse_Cerebral_Falx"                                                                                                                                                  
[23165] "Mouse_Central_Canal_of_Spinal_Cord"                                                                                                                                   
[23166] "Mouse_Cervical_Spinal_Cord"                                                                                                                                           
[23167] "Mouse_Cervical_Spinal_Nerve_Roots"                                                                                                                                    
[23168] "Mouse_Thoracic_Spinal_Cord"                                                                                                                                           
[23169] "Mouse_Lumbar_Spinal_Cord"                                                                                                                                             
[23170] "Mouse_Sacral_Spinal_Cord"                                                                                                                                             
[23171] "Mouse_Oculomotor_Nucleus"                                                                                                                                             
[23172] "Mouse_Facial_Nerve_Nucleus"                                                                                                                                           
[23173] "Mouse_Hypoglossal_Nucleus"                                                                                                                                            
[23174] "Mouse_Posterior_Chamber_of_Eye"                                                                                                                                       
[23175] "Mouse_Palpebral_Conjunctiva"                                                                                                                                          
[23176] "Mouse_Bulbar_Conjunctiva"                                                                                                                                             
[23177] "Mouse_Supraclavicular_Lymph_Nodes"                                                                                                                                    
[23178] "Mouse_Axillary_Lymph_Node"                                                                                                                                            
[23179] "Mouse_Thoracic_Cavity"                                                                                                                                                
[23180] "Mouse_Posterior_Eye_Segment"                                                                                                                                          
[23181] "Mouse_Integumentary_System"                                                                                                                                           
[23182] "Mouse_Other_unique_Body_System"                                                                                                                                       
[23183] "Mouse_Hematopoietic_Body_System"                                                                                                                                      
[23184] "Mouse_Mucosa-Associated_Lymphoid_Tissue"                                                                                                                              
[23185] "Mouse_Spinal_Accessory_Nerve"                                                                                                                                         
[23186] "Mouse_Caco-2_Cells"                                                                                                                                                   
[23187] "Mouse_Abnormal_Cells"                                                                                                                                                 
[23188] "Mouse_Atypical_Lymphoblast"                                                                                                                                           
[23189] "Mouse_Small_Cleaved_Cell"                                                                                                                                             
[23190] "Mouse_Micromegakaryocyte"                                                                                                                                             
[23191] "Mouse_Cancer_Cell"                                                                                                                                                    
[23192] "Mouse_Blast_Cells"                                                                                                                                                    
[23193] "Mouse_Organ_System"                                                                                                                                                   
[23194] "Mouse_EBV-specific_Cytotoxic_T-lymphocytes"                                                                                                                           
[23195] "Mouse_Large_Granular_Lymphocytes"                                                                                                                                     
[23196] "Mouse_Tumor_Cells"                                                                                                                                                    
[23197] "Mouse_Supratentorial"                                                                                                                                                 
[23198] "Mouse_Lumbar_Spinal_Nerve_Roots"                                                                                                                                      
[23199] "Mouse_Sacral_Spinal_Nerve_Roots"                                                                                                                                      
[23200] "Mouse_Thoracic_Spinal_Nerve_Roots"                                                                                                                                    
[23201] "Mouse_Renal_Calyces"                                                                                                                                                  
[23202] "Mouse_Corneal_Epithelium"                                                                                                                                             
[23203] "Mouse_Nerve_Plexi"                                                                                                                                                    
[23204] "Mouse_Intrapulmonary_Bronchus"                                                                                                                                        
[23205] "Mouse_Meningeal"                                                                                                                                                      
[23206] "Mouse_Xenograft"                                                                                                                                                      
[23207] "Mouse_Vertebrae"                                                                                                                                                      
[23208] "Mouse_Dorsal_Motor_Nucleus_of_the_Vagus"                                                                                                                              
[23209] "Mouse_Embryonic_Stem_Cells"                                                                                                                                           
[23210] "Mouse_Gut_Associated_Lymphoid_Tissue"                                                                                                                                 
[23211] "Mouse_Mammary_Epithelium"                                                                                                                                             
[23212] "Mouse_Peripheral_Blood_Lymphocyte"                                                                                                                                    
[23213] "Mouse_Autologous_Lymphocytes"                                                                                                                                         
[23214] "Mouse_Autologous_Tumor_Cells"                                                                                                                                         
[23215] "Mouse_Coactivated_T_Cells"                                                                                                                                            
[23216] "Mouse_Intracarotid"                                                                                                                                                   
[23217] "Mouse_Intrathecal"                                                                                                                                                    
[23218] "Mouse_Medial_Supraclavicular_Lymph_Nodes"                                                                                                                             
[23219] "Mouse_Neurosecretory_System"                                                                                                                                          
[23220] "Mouse_Peripheral_Blood_Stem_Cells"                                                                                                                                    
[23221] "Mouse_Sentinel_Lymph_Node"                                                                                                                                            
[23222] "Mouse_Ductal_Epithelium"                                                                                                                                              
[23223] "Mouse_Somatic_Cells"                                                                                                                                                  
[23224] "Mouse_Embryonic_Tissue"                                                                                                                                               
[23225] "Mouse_Splenocytes"                                                                                                                                                    
[23226] "Mouse_Upper_Aerodigestive_Passage"                                                                                                                                    
[23227] "Mouse_Nervous_System_Fluids_and_Secretions"                                                                                                                           
[23228] "Mouse_Peripheral_Blood_Mononuclear_Cell"                                                                                                                              
[23229] "Mouse_Nervous_System_Ear"                                                                                                                                             
[23230] "Mouse_Neuro-Ocular_System"                                                                                                                                            
[23231] "Mouse_Exocrine_System"                                                                                                                                                
[23232] "Mouse_Mammalian_Cell"                                                                                                                                                 
[23233] "Mouse_Breast_Cancer_Cells"                                                                                                                                            
[23234] "Mouse_Liver_Stem_Cells"                                                                                                                                               
[23235] "Mouse_Trachea_and_Bronchus"                                                                                                                                           
[23236] "Mouse_Clonogen"                                                                                                                                                       
[23237] "Mouse_Gut_Epithelium"                                                                                                                                                 
[23238] "Mouse_Connective_And_Soft_Tissue"                                                                                                                                     
[23239] "Mouse_Genital_System_Female_Other"                                                                                                                                    
[23240] "Mouse_Genital_System_Male_Other"                                                                                                                                      
[23241] "Mouse_Ascending_Spinal_Cord_Tracts"                                                                                                                                   
[23242] "Mouse_Tumor-Associated_Vasculature"                                                                                                                                   
[23243] "Mouse_Descending_Spinal_Cord_Tracts"                                                                                                                                  
[23244] "Mouse_Pontine_Base"                                                                                                                                                   
[23245] "Mouse_Breast"                                                                                                                                                         
[23246] "Mouse_Peripheral_Nerve_Sheath"                                                                                                                                        
[23247] "Mouse_Cervicomedullary_Junction"                                                                                                                                      
[23248] "Mouse_Supratentorial_Nervous_System"                                                                                                                                  
[23249] "Mouse_Infratentorial_Nervous_System"                                                                                                                                  
[23250] "Mouse_Premalignant_Cells"                                                                                                                                             
[23251] "Mouse_Pluripotent_Stem_Cell"                                                                                                                                          
[23252] "Mouse_Totipotent_Stem_Cell"                                                                                                                                           
[23253] "Mouse_Atypical_Mononuclear_Cell"                                                                                                                                      
[23254] "Mouse_Intracranial_Arteries"                                                                                                                                          
[23255] "Mouse_Graft"                                                                                                                                                          
[23256] "Mouse_Bones_of_Lower_Extremity"                                                                                                                                       
[23257] "Mouse_Bones_of_Upper_Extremity"                                                                                                                                       
[23258] "Mouse_Interval_Lymph_Node"                                                                                                                                            
[23259] "Mouse_Neural_Stem_Cells"                                                                                                                                              
[23260] "Mouse_Alveoli"                                                                                                                                                        
[23261] "Mouse_Caruncle"                                                                                                                                                       
[23262] "Mouse_Cybrid"                                                                                                                                                         
[23263] "Mouse_Episclera"                                                                                                                                                      
[23264] "Mouse_Lobule"                                                                                                                                                         
[23265] "Mouse_Neuroblast"                                                                                                                                                     
[23266] "Mouse_Red_Pulp"                                                                                                                                                       
[23267] "Mouse_White_Pulp"                                                                                                                                                     
[23268] "Mouse_Thymocyte"                                                                                                                                                      
[23269] "Mouse_Spinal_Cord_Tracts"                                                                                                                                             
[23270] "Mouse_Vestibulocochlear_Nerve"                                                                                                                                        
[23271] "Mouse_Body_Space"                                                                                                                                                     
[23272] "Mouse_Spine"                                                                                                                                                          
[23273] "Mouse_Major_Salivary_Gland_NOS"                                                                                                                                       
[23274] "Mouse_Rhabdomyocytes"                                                                                                                                                 
[23275] "Mouse_Leiomyocyte"                                                                                                                                                    
[23276] "Mouse_Cardiocyte"                                                                                                                                                     
[23277] "Mouse_Ependymocyte"                                                                                                                                                   
[23278] "Mouse_Endocardium"                                                                                                                                                    
[23279] "Mouse_Pericardium"                                                                                                                                                    
[23280] "Mouse_Epithelial_Cells_Specialized"                                                                                                                                   
[23281] "Mouse_Gross_Anatomy_Concepts"                                                                                                                                         
[23282] "Mouse_Lymphokine_Activated_Killer_Cells"                                                                                                                              
[23283] "Mouse_Histopathology_Concepts"                                                                                                                                        
[23284] "Mouse_Brunner_s_Glands"                                                                                                                                               
[23285] "Mouse_Vater_s_Ampulla"                                                                                                                                                
[23286] "Mouse_Lymphoid_Blood-Forming_Cells"                                                                                                                                   
[23287] "Mouse_Lymphoblast"                                                                                                                                                    
[23288] "Mouse_Monoblast"                                                                                                                                                      
[23289] "Mouse_Myeloblast"                                                                                                                                                     
[23290] "Mouse_Joints"                                                                                                                                                         
[23291] "Mouse_Tendons"                                                                                                                                                        
[23292] "Mouse_Ligaments"                                                                                                                                                      
[23293] "Mouse_Seminiferous_Tubules"                                                                                                                                           
[23294] "Mouse_Nephron"                                                                                                                                                        
[23295] "Mouse_Lymphoid_Tissue"                                                                                                                                                
[23296] "Mouse_Skeletal_Muscle"                                                                                                                                                
[23297] "Mouse_Hematopoietic_Tissue"                                                                                                                                           
[23298] "Mouse_Nerve_Tissue"                                                                                                                                                   
[23299] "Mouse_Vascular_Endothelium"                                                                                                                                           
[23300] "Mouse_Embryonic_Cells"                                                                                                                                                
[23301] "Mouse_Secretory_Cells"                                                                                                                                                
[23302] "Mouse_Muscle"                                                                                                                                                         
[23303] "Mouse_Reticular_Cells"                                                                                                                                                
[23304] "Mouse_Special_Sense_Organ_System"                                                                                                                                     
[23305] "Mouse_Synovial_Cells"                                                                                                                                                 
[23306] "Mouse_Sensory_Ganglia"                                                                                                                                                
[23307] "Mouse_Chromaffin_System"                                                                                                                                              
[23308] "Mouse_Back"                                                                                                                                                           
[23309] "Mouse_Neck"                                                                                                                                                           
[23310] "Mouse_Digestive_System"                                                                                                                                               
[23311] "Mouse_Oddi_s_Sphincter"                                                                                                                                               
[23312] "Mouse_Ileocecal_Valve"                                                                                                                                                
[23313] "Mouse_Solitary_Nucleus"                                                                                                                                               
[23314] "Mouse_Foot_Bones"                                                                                                                                                     
[23315] "Mouse_Stomatognathic_System"                                                                                                                                          
[23316] "Mouse_Cheek"                                                                                                                                                          
[23317] "Mouse_Face"                                                                                                                                                           
[23318] "Mouse_Dentition"                                                                                                                                                      
[23319] "Mouse_Facial_Muscles"                                                                                                                                                 
[23320] "Mouse_Masticatory_Muscles"                                                                                                                                            
[23321] "Mouse_Pharyngeal_Muscles"                                                                                                                                             
[23322] "Mouse_Bone_Tissue"                                                                                                                                                    
[23323] "Mouse_Acinar_Cells"                                                                                                                                                   
[23324] "Mouse_Ependyma"                                                                                                                                                       
[23325] "Mouse_Neural_Pathways"                                                                                                                                                
[23326] "Mouse_Afferent_Pathways"                                                                                                                                              
[23327] "Mouse_Efferent_Pathways"                                                                                                                                              
[23328] "Mouse_Internal_Capsule"                                                                                                                                               
[23329] "Mouse_Medial_Forebrain_Bundle"                                                                                                                                        
[23330] "Mouse_Perforant_Pathway"                                                                                                                                              
[23331] "Mouse_Cancer-Related_Conditions"                                                                                                                                      
[23332] "Mouse_Neoplasms"                                                                                                                                                      
[23333] "Mouse_Noncancerous_Conditions"                                                                                                                                        
[23334] "Mouse_Precancerous_Conditions"                                                                                                                                        
[23335] "Mouse_Metastatic_Neoplasms"                                                                                                                                           
[23336] "Mouse_Neoplasms_by_Histopathology"                                                                                                                                    
[23337] "Mouse_Neoplasms_by_Location"                                                                                                                                          
[23338] "Mouse_Neoplasms_by_Cell_Type"                                                                                                                                         
[23339] "Mouse_Neoplasms_by_Morphology"                                                                                                                                        
[23340] "Mouse_Acinar_Cell_Neoplasm"                                                                                                                                           
[23341] "Mouse_Ductal_Cell_Neoplasm"                                                                                                                                           
[23342] "Mouse_Epithelial_Cell_Neoplasms"                                                                                                                                      
[23343] "Mouse_Germ_Cell_Neoplasm"                                                                                                                                             
[23344] "Mouse_Granulosa_Cell_Tumor"                                                                                                                                           
[23345] "Mouse_Lymph_Cell_Neoplasm"                                                                                                                                            
[23346] "Mouse_Melanocyte_Neoplasm"                                                                                                                                            
[23347] "Mouse_Mesenchymal_Neoplasm"                                                                                                                                           
[23348] "Mouse_Monocyte_Neoplasm"                                                                                                                                              
[23349] "Mouse_Myeloid_Cell_Neoplasm"                                                                                                                                          
[23350] "Mouse_Neural_Cell_Neoplasm"                                                                                                                                           
[23351] "Mouse_Plasma_Cell_Dyscrasia"                                                                                                                                          
[23352] "Mouse_Transitional_Cell_Neoplasm"                                                                                                                                     
[23353] "Mouse_Adenoma"                                                                                                                                                        
[23354] "Mouse_Carcinoma"                                                                                                                                                      
[23355] "Mouse_Adenocarcinoma"                                                                                                                                                 
[23356] "Mouse_Squamous_Cell_Neoplasm"                                                                                                                                         
[23357] "Mouse_Adenosquamous_Carcinoma"                                                                                                                                        
[23358] "Mouse_Benign_Epithelial_Neoplasm"                                                                                                                                     
[23359] "Mouse_Papilloma"                                                                                                                                                      
[23360] "Mouse_Angiosarcoma"                                                                                                                                                   
[23361] "Mouse_Fibrosarcoma"                                                                                                                                                   
[23362] "Mouse_Chondrosarcoma"                                                                                                                                                 
[23363] "Mouse_Kaposi_s_Sarcoma"                                                                                                                                               
[23364] "Mouse_Leiomyosarcoma"                                                                                                                                                 
[23365] "Mouse_Osteosarcoma"                                                                                                                                                   
[23366] "Mouse_Rhabdomyosarcoma"                                                                                                                                               
[23367] "Mouse_Synovial_Sarcoma"                                                                                                                                               
[23368] "Mouse_Gastrointestinal_System_Neoplasms"                                                                                                                              
[23369] "Mouse_Hepatic_System_Neoplasms"                                                                                                                                       
[23370] "Mouse_Benign_Hepatic_System_Neoplasms"                                                                                                                                
[23371] "Mouse_Malignant_Hepatic_System_Neoplasms"                                                                                                                             
[23372] "Mouse_Hepatocellular_Adenoma"                                                                                                                                         
[23373] "Mouse_Hepatocellular_Carcinoma"                                                                                                                                       
[23374] "Mouse_Genitourinary_Neoplasms"                                                                                                                                        
[23375] "Mouse_Reproductive_System_Neoplasms"                                                                                                                                  
[23376] "Mouse_Male_Reproductive_System_Neoplasms"                                                                                                                             
[23377] "Mouse_Female_Reproductive_System_Neoplasms"                                                                                                                           
[23378] "Mouse_Digestive_System_Neoplasms"                                                                                                                                     
[23379] "Mouse_Integumentary_System_Neoplasms"                                                                                                                                 
[23380] "Mouse_Adrenal_Gland_Neoplasms"                                                                                                                                        
[23381] "Mouse_Pituitary_Gland_Neoplasms"                                                                                                                                      
[23382] "Mouse_Pancreatic_Neoplasms"                                                                                                                                           
[23383] "Tumors_of_the_Mouse_Pulmonary_System"                                                                                                                                 
[23384] "Mouse_Special_Sense_Organ_Neoplasms"                                                                                                                                  
[23385] "Biliary_Tract_MMHCC"                                                                                                                                                  
[23386] "Bile_Duct_MMHCC"                                                                                                                                                      
[23387] "Exocrine_Pancreas_MMHCC"                                                                                                                                              
[23388] "Pancreas_MMHCC"                                                                                                                                                       
[23389] "Exocrine_Pancreas_Ductal_System_MMHCC"                                                                                                                                
[23390] "Lateral_Prostate_Gland_MMHCC"                                                                                                                                         
[23391] "Dorsal_Prostate_Gland_MMHCC"                                                                                                                                          
[23392] "Ventral_Prostate_Gland_MMHCC"                                                                                                                                         
[23393] "Lung_Bronchus_MMHCC"                                                                                                                                                  
[23394] "Mouse_Fallopian_Tube_Neoplasm"                                                                                                                                        
[23395] "Benign_Mouse_Fallopian_Tube_Neoplasm"                                                                                                                                 
[23396] "Malignant_Mouse_Fallopian_Tube_Neoplasm"                                                                                                                              
[23397] "Mouse_Fallopian_Tube_Carcinoma"                                                                                                                                       
[23398] "Mouse_Fallopian_Tube_Adenocarcinoma"                                                                                                                                  
[23399] "Mouse_Fallopian_Tube_Clear_Cell_Adenocarcinoma"                                                                                                                       
[23400] "Mouse_Fallopian_Tube_Endometrioid_Adenocarcinoma"                                                                                                                     
[23401] "Mouse_Fallopian_Tube_Mucinous_Adenocarcinoma"                                                                                                                         
[23402] "Mouse_Fallopian_Tube_Papillary_Adenocarcinoma"                                                                                                                        
[23403] "Mouse_Fallopian_Tube_Papillary_Serous_Adenocarcinoma"                                                                                                                 
[23404] "Mouse_Fallopian_Tube_Serous_Adenocarcinoma"                                                                                                                           
[23405] "Fallopian_Tube_Papillary_Serous_Adenocarcinoma_of_Mouse"                                                                                                              
[23406] "Mouse_Fallopian_Tube_Gestational_Choriocarcinoma"                                                                                                                     
[23407] "Mouse_Fallopian_Tube_Squamous_Cell_Carcinoma"                                                                                                                         
[23408] "Undifferentiated_Mouse_Fallopian_Tube_Carcinoma"                                                                                                                      
[23409] "Malignant_Mouse_Uterine_Neoplasms"                                                                                                                                    
[23410] "Malignant_Mouse_Cervical_Neoplasm"                                                                                                                                    
[23411] "Mouse_Cervical_Carcinoma"                                                                                                                                             
[23412] "Mouse_Cervical_Adenocarcinoma"                                                                                                                                        
[23413] "Mouse_Cervical_Adenocarcinoma_in_Situ"                                                                                                                                
[23414] "Mouse_Mesonephric_Adenocarcinoma"                                                                                                                                     
[23415] "Mouse_Uterine_Cervix_Clear_Cell_Adenocarcinoma"                                                                                                                       
[23416] "Mouse_Uterine_Cervix_Endometrioid_Adenocarcinoma"                                                                                                                     
[23417] "Mouse_Cervical_Adenoid_Cystic_Carcinoma"                                                                                                                              
[23418] "Mouse_Cervical_Adenosquamous_Cell_Carcinoma"                                                                                                                          
[23419] "Mouse_Cervical_Small_Cell_Carcinoma"                                                                                                                                  
[23420] "Mouse_Cervical_Squamous_Cell_Carcinoma"                                                                                                                               
[23421] "Mouse_Endocervical_Carcinoma"                                                                                                                                         
[23422] "Mouse_Exocervical_Carcinoma"                                                                                                                                          
[23423] "Mouse_Infiltrating_Cervical_Carcinoma"                                                                                                                                
[23424] "Mouse_Recurrent_Cervical_Carcinoma"                                                                                                                                   
[23425] "Undifferentiated_Mouse_Cervical_Carcinoma"                                                                                                                            
[23426] "Malignant_Mouse_Endocervical_Neoplasm"                                                                                                                                
[23427] "Malignant_Mouse_Exocervical_Neoplasm"                                                                                                                                 
[23428] "Metastasis_to_the_Mouse_Cervix"                                                                                                                                       
[23429] "Metastatic_Carcinoma_to_the_Mouse_Uterine_Cervix"                                                                                                                     
[23430] "Malignant_Mouse_Uterine_Corpus_Neoplasm"                                                                                                                              
[23431] "Mouse_Endometrial_Carcinoma"                                                                                                                                          
[23432] "Mouse_Endometrial_Adenocarcinoma"                                                                                                                                     
[23433] "Mouse_Endometrial_Adenocarcinoma_with_Squamous_Metaplasia"                                                                                                            
[23434] "Mouse_Endometrial_Clear_Cell_Adenocarcinoma"                                                                                                                          
[23435] "Mouse_Endometrial_Endometrioid_Adenocarcinoma"                                                                                                                        
[23436] "Mouse_Endometrial_Mucinous_Adenocarcinoma"                                                                                                                            
[23437] "Serous_Carcinoma_of_the_Mouse_Endometrium"                                                                                                                            
[23438] "Papillary_Serous_Carcinoma_of_the_Mouse_Endometrium"                                                                                                                  
[23439] "Mouse_Endometrial_Mixed_Carcinoma"                                                                                                                                    
[23440] "Mouse_Endometrial_Adenosquamous_Carcinoma"                                                                                                                            
[23441] "Mouse_Endometrial_Squamous_Cell_Carcinoma"                                                                                                                            
[23442] "Recurrent_Malignant_Mouse_Endometrial_Neoplasm"                                                                                                                       
[23443] "Recurrent_Mouse_Endometrial_Carcinoma"                                                                                                                                
[23444] "Undifferentiated_Mouse_Endometrial_Carcinoma"                                                                                                                         
[23445] "Malignant_Mouse_Uterine_Corpus_Mixed_Neoplasm"                                                                                                                        
[23446] "Mouse_Uterine_Malignant_Mixed_Mesodermal_Mullerian_Tumor"                                                                                                             
[23447] "Mouse_Uterine_Mullerian_Adenosarcoma"                                                                                                                                 
[23448] "Mouse_Uterine_Choriocarcinoma"                                                                                                                                        
[23449] "Mouse_Uterine_Gestational_Choriocarcinoma"                                                                                                                            
[23450] "Mouse_Uterine_Sarcoma"                                                                                                                                                
[23451] "Mouse_Endometrial_Stromal_Sarcoma"                                                                                                                                    
[23452] "Recurrent_Mouse_Uterine_Sarcoma"                                                                                                                                      
[23453] "Malignant_Mouse_Placental_Neoplasm"                                                                                                                                   
[23454] "Metastasis_to_the_Mouse_Placenta"                                                                                                                                     
[23455] "Mouse_Placental_Choriocarcinoma"                                                                                                                                      
[23456] "Mouse_Connective_and_Soft_Tissue_Neoplasms"                                                                                                                           
[23457] "Mouse_Lipomatous_Neoplasm"                                                                                                                                            
[23458] "Malignant_Mouse_Lipomatous_Neoplasm"                                                                                                                                  
[23459] "Mouse_Soft_Tissue_Neoplasm"                                                                                                                                           
[23460] "Mouse_Myomatous_Neoplasm"                                                                                                                                             
[23461] "Malignant_Mouse_Muscle_Neoplasm"                                                                                                                                      
[23462] "Malignant_Mouse_Smooth_Muscle_Neoplasm"                                                                                                                               
[23463] "Malignant_Mouse_Skeletal_Muscle_Neoplasm"                                                                                                                             
[23464] "Mouse_Bile_Duct_Neoplasm"                                                                                                                                             
[23465] "Mouse_Bile_Duct_Adenoma"                                                                                                                                              
[23466] "Mouse_Intrahepatic_Bile_Duct_Adenoma"                                                                                                                                 
[23467] "Mouse_Extrahepatic_Bile_Duct_Adenoma"                                                                                                                                 
[23468] "Mouse_Extrahepatic_Bile_Duct_Papillary_Adenoma"                                                                                                                       
[23469] "Mouse_Extrahepatic_Bile_Duct_Tubular_Adenoma"                                                                                                                         
[23470] "Mouse_Bile_Duct_Cystadenoma"                                                                                                                                          
[23471] "Mouse_Extrahepatic_Bile_Duct_Cystadenoma"                                                                                                                             
[23472] "Mouse_Intrahepatic_Bile_Duct_Cystadenoma"                                                                                                                             
[23473] "Mouse_Bile_Duct_Papillomatosis"                                                                                                                                       
[23474] "Mouse_Extrahepatic_Bile_Duct_Papillomatosis"                                                                                                                          
[23475] "Mouse_Intrahepatic_Bile_Duct_Papillomatosis"                                                                                                                          
[23476] "Mouse_Extrahepatic_Bile_Duct_Neoplasm"                                                                                                                                
[23477] "Malignant_Mouse_Extrahepatic_Bile_Duct_Neoplasm"                                                                                                                      
[23478] "Mouse_Bile_Duct_Sarcoma"                                                                                                                                              
[23479] "Mouse_Extrahepatic_Bile_Duct_Leiomyosarcoma"                                                                                                                          
[23480] "Malignant_Mouse_Extrahepatic_Bile_Duct_Fibrous_Histocytoma"                                                                                                           
[23481] "Mouse_Bile_Duct_Rhabdomyosarcoma"                                                                                                                                     
[23482] "Mouse_Extrahepatic_Bile_Duct_Embryonal_Rhabdomyosarcoma"                                                                                                              
[23483] "Mouse_Extrahepatic_Bile_Duct_Carcinoid_Neoplasm"                                                                                                                      
[23484] "Mouse_Extrahepatic_Bile_Duct_Carcinoma"                                                                                                                               
[23485] "Mouse_Adenosquamous_Bile_Duct_Carcinoma"                                                                                                                              
[23486] "Mouse_Bile_Duct_Mucoepidermoid_Carcinoma"                                                                                                                             
[23487] "Mouse_Bile_Duct_Small_Cell_Carcinoma"                                                                                                                                 
[23488] "Mouse_Squamous_Cell_Bile_Duct_Carcinoma"                                                                                                                              
[23489] "Mouse_Gallbladder_Neoplasm"                                                                                                                                           
[23490] "Malignant_Mouse_Gallbladder_Neoplasm"                                                                                                                                 
[23491] "Mouse_Gallbladder_Carcinoma"                                                                                                                                          
[23492] "Mouse_Gallbladder_Adenocarcinoma"                                                                                                                                     
[23493] "Mouse_Gallbladder_Squamous_Cell_Gallbladder"                                                                                                                          
[23494] "Mouse_Gallbladder_Small_Cell_Gallbladder"                                                                                                                             
[23495] "Mouse_Gallbladder_Carcinosarcoma"                                                                                                                                     
[23496] "Mouse_Gallbladder_Lymphoma"                                                                                                                                           
[23497] "Mouse_Gallbladder_Mucosa_Associated_Lymphoid_Tissue_Lymphoma"                                                                                                         
[23498] "Mouse_Gallbladder_Melanoma"                                                                                                                                           
[23499] "Mouse_Gallbladder_Sarcoma"                                                                                                                                            
[23500] "Mouse_Gallbladder_Angiosarcoma"                                                                                                                                       
[23501] "Mouse_Gallbladder_Kaposi_s_Sarcoma"                                                                                                                                   
[23502] "Mouse_Gallbladder_Leiomyosarcoma"                                                                                                                                     
[23503] "Mouse_Gallbladder_Malignant_Fibrous_Histiocytoma"                                                                                                                     
[23504] "Rhabdomyosarcoma_of_the_Mouse_Gallbladder"                                                                                                                            
[23505] "Metastatic_Neoplasm_to_the_Mouse_Gallbladder"                                                                                                                         
[23506] "Mouse_Thyroid_Neoplasm"                                                                                                                                               
[23507] "Malignant_Mouse_Thyroid_Neoplasm"                                                                                                                                     
[23508] "Metastasis_to_the_Mouse_Thyroid"                                                                                                                                      
[23509] "Mouse_Thyroid_Carcinoma"                                                                                                                                              
[23510] "Mouse_Anaplastic_Thyroid_Carcinoma"                                                                                                                                   
[23511] "Mouse_Anaplastic_Giant_Cell_Thyroid_Carcinoma"                                                                                                                        
[23512] "Mouse_Anaplastic_Small_Cell_Thyroid_Carcinoma"                                                                                                                        
[23513] "Mouse_Medullary_Thyroid_Carcinoma"                                                                                                                                    
[23514] "Mouse_Medullary_Thyroid_Carcinoma_with_Amyloid_Stroma"                                                                                                                
[23515] "Poorly_Differentiated_Mouse_Thyroid_Carcinoma"                                                                                                                        
[23516] "Recurrent_Mouse_Thyroid_Carcinoma"                                                                                                                                    
[23517] "Well-Differentiated_Mouse_Thyroid_Carcinoma"                                                                                                                          
[23518] "Mouse_Follicular_Thyroid_Carcinoma"                                                                                                                                   
[23519] "Mouse_Trabecular_Follicular_Adenocarcinoma"                                                                                                                           
[23520] "Mouse_Hurthle_Cell_Carcinoma_of_the_Thyroid"                                                                                                                          
[23521] "Mouse_Papillary_Thyroid_Carcinoma"                                                                                                                                    
[23522] "Mouse_Follicular_Variant_Papillary_Carcinoma"                                                                                                                         
[23523] "Mouse_Papillary_and_Follicular_Adenocarcinoma"                                                                                                                        
[23524] "Mouse_Thyroid_Lymphoma"                                                                                                                                               
[23525] "Mouse_Thyroid_Hodgkin_s_Lymphoma"                                                                                                                                     
[23526] "Mouse_Thyroid_Non-Hodgkin_s_Lymphoma"                                                                                                                                 
[23527] "Mouse_Thyroid_Diffuse_Large_B-Cell_Lymphoma"                                                                                                                          
[23528] "Mouse_Thyroid_Immunoblastic_Lymphoma"                                                                                                                                 
[23529] "Mouse_Thyroid_Plasmacytoma"                                                                                                                                           
[23530] "Mouse_Thyroid_Sarcoma"                                                                                                                                                
[23531] "Mouse_Thyroid_Angiosarcoma"                                                                                                                                           
[23532] "PNS_Motor_and_Sensory_Nerves_MMHCC"                                                                                                                                   
[23533] "Autonomic_Nerves_MMHCC"                                                                                                                                               
[23534] "Dendritic_Cell_Langerhans_Cell_MMHCC"                                                                                                                                 
[23535] "Reproductive_System_MMHCC"                                                                                                                                            
[23536] "Germ_Cell_MMHCC"                                                                                                                                                      
[23537] "Musculoskeletal_System_MMHCC"                                                                                                                                         
[23538] "Embryonic_Tissue_MMHCC"                                                                                                                                               
[23539] "Embryonic_Tissue_MEF_MMHCC"                                                                                                                                           
[23540] "Mouse_Chondrocyte_Neoplasm"                                                                                                                                           
[23541] "Connective_Tissue_Reticular_Cells_MMHCC"                                                                                                                              
[23542] "Mouse_Chondrogenic_Neoplasm"                                                                                                                                          
[23543] "Mouse_Gastric_Neoplasm"                                                                                                                                               
[23544] "Benign_Mouse_Gastric_Neoplasm"                                                                                                                                        
[23545] "Benign_Mouse_Gastric_Gastrointestinal_Stromal_Neoplasm"                                                                                                               
[23546] "Benign_Mouse_Gastric_Granular_Cell_Tumor"                                                                                                                             
[23547] "Mouse_Gastric_Hamartoma"                                                                                                                                              
[23548] "Mouse_Gastric_Leiomyoma"                                                                                                                                              
[23549] "Mouse_Gastric_Epithelioid_Leiomyoma"                                                                                                                                  
[23550] "Mouse_Gastric_Lipoma"                                                                                                                                                 
[23551] "Mouse_Gastric_Germ_Cell_Neoplasm"                                                                                                                                     
[23552] "Malignant_Mouse_Gastric_Germ_Cell_Neoplasm"                                                                                                                           
[23553] "Immature_Mouse_Gastric_Teratoma"                                                                                                                                      
[23554] "Mouse_Gastric_Mesenchymal_Neoplasm"                                                                                                                                   
[23555] "Mouse_Gastric_Gastrointestinal_Stromal_Tumor"                                                                                                                         
[23556] "Malignant_Mouse_Gastric_Gastrointestinal_Stromal_Tumor"                                                                                                               
[23557] "Mouse_Gastric_Hemangioma"                                                                                                                                             
[23558] "Mouse_Gastric_Inflammatory_Myofibroblastic_Neoplasm"                                                                                                                  
[23559] "Mouse_Gastric_Liposarcoma"                                                                                                                                            
[23560] "Mouse_Gastric_Xanthoma"                                                                                                                                               
[23561] "Malignant_Mouse_Gastric_Fibrous_Histocytoma"                                                                                                                          
[23562] "Mouse_Gastric_Neuroendocrine_Neoplasm"                                                                                                                                
[23563] "Mouse_Gastric_Carcinoid_Neoplasm"                                                                                                                                     
[23564] "Mouse_Gastric_Small_Cell_Carcinoma"                                                                                                                                   
[23565] "Mouse_Gastric_Teratoma"                                                                                                                                               
[23566] "Mature_Mouse_Gastric_Teratoma"                                                                                                                                        
[23567] "Malignant_Mouse_Gastric_Neoplasm"                                                                                                                                     
[23568] "Mouse_Gastric_Carcinoma"                                                                                                                                              
[23569] "Carcinoma_in_situ_of_the_Mouse_Antrum"                                                                                                                                
[23570] "Mouse_Gastric_Adenocarcinoma"                                                                                                                                         
[23571] "Mouse_Gastric_Adenosquamous_Carcinoma"                                                                                                                                
[23572] "Mouse_Gastric_Body_Carcinoma"                                                                                                                                         
[23573] "Mouse_Gastric_Cardia_Carcinoma"                                                                                                                                       
[23574] "Mouse_Gastric_Fundus_Carcinoma"                                                                                                                                       
[23575] "Mouse_Gastric_Kaposi_s_Sarcoma"                                                                                                                                       
[23576] "Mouse_Gastric_Pylorus_Carcinoma"                                                                                                                                      
[23577] "Mouse_Gastric_Squamous_Cell_Carcinoma"                                                                                                                                
[23578] "Recurrent_Mouse_Gastric_Cancer"                                                                                                                                       
[23579] "Mouse_Gastric_Lymphoma"                                                                                                                                               
[23580] "Mouse_Gastric_Hodgkin_s_Lymphoma"                                                                                                                                     
[23581] "Primary_Mouse_Gastric_Non-Hodgkin_s_Lymphoma"                                                                                                                         
[23582] "Secondary_Mouse_Gastric_Non-Hodgkin_s_Lymphoma"                                                                                                                       
[23583] "Malignant_Mouse_Gastric_Cardio-Esophageal_Junction_Neoplasm"                                                                                                          
[23584] "Mouse_Barrett_s_Adenocarcinoma"                                                                                                                                       
[23585] "Malignant_Mouse_Gastric_Granular_Cell_Tumor"                                                                                                                          
[23586] "Mixed_Malignant_Mouse_Gastric_Neoplasm"                                                                                                                               
[23587] "Mouse_Gastric_Carcinosarcoma"                                                                                                                                         
[23588] "ANXA5_Gene"                                                                                                                                                           
[23589] "ARRB1_Gene"                                                                                                                                                           
[23590] "ATP8A2_Gene"                                                                                                                                                          
[23591] "AVP_Gene"                                                                                                                                                             
[23592] "AVPR1A_Gene"                                                                                                                                                          
[23593] "AVPR1B_Gene"                                                                                                                                                          
[23594] "AVPR2_Gene"                                                                                                                                                           
[23595] "BAG4_Gene"                                                                                                                                                            
[23596] "BAG5_Gene"                                                                                                                                                            
[23597] "BAI1_Gene"                                                                                                                                                            
[23598] "BAI2_Gene"                                                                                                                                                            
[23599] "BAI3_Gene"                                                                                                                                                            
[23600] "BAIAP1_Gene"                                                                                                                                                          
[23601] "BAIAP2_Gene"                                                                                                                                                          
[23602] "BCL10_Gene"                                                                                                                                                           
[23603] "BCL6_Gene"                                                                                                                                                            
[23604] "BCL7A_Gene"                                                                                                                                                           
[23605] "BCL9_Gene"                                                                                                                                                            
[23606] "WDR22_Gene"                                                                                                                                                           
[23607] "BDKRB2_Gene"                                                                                                                                                          
[23608] "BIN1_Gene"                                                                                                                                                            
[23609] "BLR1_Gene"                                                                                                                                                            
[23610] "CCM1_Gene"                                                                                                                                                            
[23611] "CCNB2_Gene"                                                                                                                                                           
[23612] "CCR1_Gene"                                                                                                                                                            
[23613] "CCR5_Gene"                                                                                                                                                            
[23614] "CCR6_Gene"                                                                                                                                                            
[23615] "CCR8_Gene"                                                                                                                                                            
[23616] "CCR9_Gene"                                                                                                                                                            
[23617] "CCRL1_Gene"                                                                                                                                                           
[23618] "CCRL2_Gene"                                                                                                                                                           
[23619] "CCXCR1_Gene"                                                                                                                                                          
[23620] "CD3E_Gene"                                                                                                                                                            
[23621] "CD47_Gene"                                                                                                                                                            
[23622] "CD97_Gene"                                                                                                                                                            
[23623] "CDC2L1_Gene"                                                                                                                                                          
[23624] "CDC37_Gene"                                                                                                                                                           
[23625] "CDC42_Gene"                                                                                                                                                           
[23626] "CDK10_Gene"                                                                                                                                                           
[23627] "CDK2_Gene"                                                                                                                                                            
[23628] "CDK2AP1_Gene"                                                                                                                                                         
[23629] "CDK3_Gene"                                                                                                                                                            
[23630] "CDKL2_Gene"                                                                                                                                                           
[23631] "CDKN2C_Gene"                                                                                                                                                          
[23632] "CDKN3_Gene"                                                                                                                                                           
[23633] "CDON_Gene"                                                                                                                                                            
[23634] "CDR1_Gene"                                                                                                                                                            
[23635] "CDX2_Gene"                                                                                                                                                            
[23636] "CEACAM7_Gene"                                                                                                                                                         
[23637] "CELSR1_Gene"                                                                                                                                                          
[23638] "CHEK1_Gene"                                                                                                                                                           
[23639] "CHK_Gene"                                                                                                                                                             
[23640] "CHRM4_Gene"                                                                                                                                                           
[23641] "CHS1_Gene"                                                                                                                                                            
[23642] "CISH_Gene"                                                                                                                                                            
[23643] "CLC_Gene"                                                                                                                                                             
[23644] "CMKLR1_Gene"                                                                                                                                                          
[23645] "CNK_Gene"                                                                                                                                                             
[23646] "CNK1_Gene"                                                                                                                                                            
[23647] "CNTNAP1_Gene"                                                                                                                                                         
[23648] "COL18A1_Gene"                                                                                                                                                         
[23649] "COL4A3_Gene"                                                                                                                                                          
[23650] "COL4A6_Gene"                                                                                                                                                          
[23651] "COX6C_Gene"                                                                                                                                                           
[23652] "CPNE7_Gene"                                                                                                                                                           
[23653] "CSF2_Gene"                                                                                                                                                            
[23654] "CSF2RB_Gene"                                                                                                                                                          
[23655] "CSF3_Gene"                                                                                                                                                            
[23656] "CSF3R_Gene"                                                                                                                                                           
[23657] "CSNK1A1_Gene"                                                                                                                                                         
[23658] "CSNK2A1_Gene"                                                                                                                                                         
[23659] "CSPG4_Gene"                                                                                                                                                           
[23660] "CSPG6_Gene"                                                                                                                                                           
[23661] "CTBP2_Gene"                                                                                                                                                           
[23662] "CTF1_Gene"                                                                                                                                                            
[23663] "CTSZ_Gene"                                                                                                                                                            
[23664] "CUL1_Gene"                                                                                                                                                            
[23665] "CUL2_Gene"                                                                                                                                                            
[23666] "CUL3_Gene"                                                                                                                                                            
[23667] "CUL4A_Gene"                                                                                                                                                           
[23668] "CUL5_Gene"                                                                                                                                                            
[23669] "CX3CR1_Gene"                                                                                                                                                          
[23670] "CXCR4_Gene"                                                                                                                                                           
[23671] "CYP3A4_Gene"                                                                                                                                                          
[23672] "DAB2_Gene"                                                                                                                                                            
[23673] "DAXX_Gene"                                                                                                                                                            
[23674] "DBCCR1_Gene"                                                                                                                                                          
[23675] "MAP17_Gene"                                                                                                                                                           
[23676] "DDR2_Gene"                                                                                                                                                            
[23677] "DDX1_Gene"                                                                                                                                                            
[23678] "DDX16_Gene"                                                                                                                                                           
[23679] "DDX26_Gene"                                                                                                                                                           
[23680] "DEC1_Gene"                                                                                                                                                            
[23681] "DEFB1_Gene"                                                                                                                                                           
[23682] "DEK_Gene"                                                                                                                                                             
[23683] "DLEC1_Gene"                                                                                                                                                           
[23684] "DLEU1_Gene"                                                                                                                                                           
[23685] "DLEU2_Gene"                                                                                                                                                           
[23686] "DLG1_Gene"                                                                                                                                                            
[23687] "DLG4_Gene"                                                                                                                                                            
[23688] "DMBT1_Gene"                                                                                                                                                           
[23689] "DNMT3B_Gene"                                                                                                                                                          
[23690] "DOC-1R_Gene"                                                                                                                                                          
[23691] "DOCK1_Gene"                                                                                                                                                           
[23692] "DOK1_Gene"                                                                                                                                                            
[23693] "DRD1_Gene"                                                                                                                                                            
[23694] "DRD4_Gene"                                                                                                                                                            
[23695] "DRD5_Gene"                                                                                                                                                            
[23696] "DTR_Gene"                                                                                                                                                             
[23697] "DTX1_Gene"                                                                                                                                                            
[23698] "DUSP1_Gene"                                                                                                                                                           
[23699] "EBAF_Gene"                                                                                                                                                            
[23700] "ECGF1_Gene"                                                                                                                                                           
[23701] "EDN2_Gene"                                                                                                                                                            
[23702] "EGF_Gene"                                                                                                                                                             
[23703] "EGFL6_Gene"                                                                                                                                                           
[23704] "EHF_Gene"                                                                                                                                                             
[23705] "EMILIN_Gene"                                                                                                                                                          
[23706] "EPHA2_Gene"                                                                                                                                                           
[23707] "EPHA4_Gene"                                                                                                                                                           
[23708] "EPHA8_Gene"                                                                                                                                                           
[23709] "EPHB1_Gene"                                                                                                                                                           
[23710] "EPHB2_Gene"                                                                                                                                                           
[23711] "EPHB3_Gene"                                                                                                                                                           
[23712] "EPS15_Gene"                                                                                                                                                           
[23713] "EPS8_Gene"                                                                                                                                                            
[23714] "EPS8L1_Gene"                                                                                                                                                          
[23715] "EPS8L2_Gene"                                                                                                                                                          
[23716] "EPS8L3_Gene"                                                                                                                                                          
[23717] "ERBB2IP_Gene"                                                                                                                                                         
[23718] "EREG_Gene"                                                                                                                                                            
[23719] "ERF_Gene"                                                                                                                                                             
[23720] "ETV1_Gene"                                                                                                                                                            
[23721] "ETV4_Gene"                                                                                                                                                            
[23722] "EVI2B_Gene"                                                                                                                                                           
[23723] "EXTL1_Gene"                                                                                                                                                           
[23724] "EXTL2_Gene"                                                                                                                                                           
[23725] "EXTL3_Gene"                                                                                                                                                           
[23726] "F2R_Gene"                                                                                                                                                             
[23727] "FADD_Gene"                                                                                                                                                            
[23728] "FANCG_Gene"                                                                                                                                                           
[23729] "GLMN_Gene"                                                                                                                                                            
[23730] "FASTK_Gene"                                                                                                                                                           
[23731] "FGF1_Gene"                                                                                                                                                            
[23732] "FGF10_Gene"                                                                                                                                                           
[23733] "FGF20_Gene"                                                                                                                                                           
[23734] "FGF21_Gene"                                                                                                                                                           
[23735] "FGF8_Gene"                                                                                                                                                            
[23736] "FGFR3_Gene"                                                                                                                                                           
[23737] "FGFRL1_Gene"                                                                                                                                                          
[23738] "FHL2_Gene"                                                                                                                                                            
[23739] "FIBP_Gene"                                                                                                                                                            
[23740] "THSD2_Gene"                                                                                                                                                           
[23741] "FLRT3_Gene"                                                                                                                                                           
[23742] "FLT3_Gene"                                                                                                                                                            
[23743] "FLT4_Gene"                                                                                                                                                            
[23744] "FGFR1OP_Gene"                                                                                                                                                         
[23745] "FOXO1A_Gene"                                                                                                                                                          
[23746] "FPR1_Gene"                                                                                                                                                            
[23747] "FRAG1_Gene"                                                                                                                                                           
[23748] "FRAT1_Gene"                                                                                                                                                           
[23749] "FRK_Gene"                                                                                                                                                             
[23750] "FRSB_Gene"                                                                                                                                                            
[23751] "FSTL3_Gene"                                                                                                                                                           
[23752] "PDAP2_Gene"                                                                                                                                                           
[23753] "FVT1_Gene"                                                                                                                                                            
[23754] "FZD2_Gene"                                                                                                                                                            
[23755] "FZD3_Gene"                                                                                                                                                            
[23756] "FZD4_Gene"                                                                                                                                                            
[23757] "FZD6_Gene"                                                                                                                                                            
[23758] "FZD7_Gene"                                                                                                                                                            
[23759] "FZD9_Gene"                                                                                                                                                            
[23760] "GAB2_Gene"                                                                                                                                                            
[23761] "GAC1_Gene"                                                                                                                                                            
[23762] "GADD45A_Gene"                                                                                                                                                         
[23763] "GALR2_Gene"                                                                                                                                                           
[23764] "GAS41_Gene"                                                                                                                                                           
[23765] "GCG_Gene"                                                                                                                                                             
[23766] "GDF10_Gene"                                                                                                                                                           
[23767] "GDF5_Gene"                                                                                                                                                            
[23768] "GDF8_Gene"                                                                                                                                                            
[23769] "GDF9_Gene"                                                                                                                                                            
[23770] "GFI1B_Gene"                                                                                                                                                           
[23771] "GFRA2_Gene"                                                                                                                                                           
[23772] "GIPR_Gene"                                                                                                                                                            
[23773] "GIT1_Gene"                                                                                                                                                            
[23774] "GIT2_Gene"                                                                                                                                                            
[23775] "GLI_Gene"                                                                                                                                                             
[23776] "GLTSCR1_Gene"                                                                                                                                                         
[23777] "GLTSCR2_Gene"                                                                                                                                                         
[23778] "GNA12_Gene"                                                                                                                                                           
[23779] "GNAI2_Gene"                                                                                                                                                           
[23780] "GNAZ_Gene"                                                                                                                                                            
[23781] "GNB1_Gene"                                                                                                                                                            
[23782] "GNB2_Gene"                                                                                                                                                            
[23783] "GNB3_Gene"                                                                                                                                                            
[23784] "GPA33_Gene"                                                                                                                                                           
[23785] "GPR17_Gene"                                                                                                                                                           
[23786] "GPR2_Gene"                                                                                                                                                            
[23787] "GPR32_Gene"                                                                                                                                                           
[23788] "GPR68_Gene"                                                                                                                                                           
[23789] "CXCR3_Gene"                                                                                                                                                           
[23790] "GPRC5C_Gene"                                                                                                                                                          
[23791] "GPRK2L_Gene"                                                                                                                                                          
[23792] "GPRK5_Gene"                                                                                                                                                           
[23793] "GPRK6_Gene"                                                                                                                                                           
[23794] "GPRK7_Gene"                                                                                                                                                           
[23795] "GPS1_Gene"                                                                                                                                                            
[23796] "GPS2_Gene"                                                                                                                                                            
[23797] "GR6_Gene"                                                                                                                                                             
[23798] "GRAP_Gene"                                                                                                                                                            
[23799] "GRB10_Gene"                                                                                                                                                           
[23800] "GRB14_Gene"                                                                                                                                                           
[23801] "GRB2_Gene"                                                                                                                                                            
[23802] "GRB7_Gene"                                                                                                                                                            
[23803] "GRF2_Gene"                                                                                                                                                            
[23804] "GRIA3_Gene"                                                                                                                                                           
[23805] "GRM1_Gene"                                                                                                                                                            
[23806] "GRM5_Gene"                                                                                                                                                            
[23807] "GRM6_Gene"                                                                                                                                                            
[23808] "GSTT1_Gene"                                                                                                                                                           
[23809] "HDAC5_Gene"                                                                                                                                                           
[23810] "HGF_Gene"                                                                                                                                                             
[23811] "HGS_Gene"                                                                                                                                                             
[23812] "HHCM_Gene"                                                                                                                                                            
[23813] "HK2_Gene"                                                                                                                                                             
[23814] "HM74_Gene"                                                                                                                                                            
[23815] "HNRPA3_Gene"                                                                                                                                                          
[23816] "HOXA10_Gene"                                                                                                                                                          
[23817] "HOXA9_Gene"                                                                                                                                                           
[23818] "HOXC6_Gene"                                                                                                                                                           
[23819] "HPCA_Gene"                                                                                                                                                            
[23820] "HPSE_Gene"                                                                                                                                                            
[23821] "HSD17B7_Gene"                                                                                                                                                         
[23822] "HTATIP2_Gene"                                                                                                                                                         
[23823] "IFITM1_Gene"                                                                                                                                                          
[23824] "IFNA13_Gene"                                                                                                                                                          
[23825] "IFNA2_Gene"                                                                                                                                                           
[23826] "IFNW1_Gene"                                                                                                                                                           
[23827] "IGBP1_Gene"                                                                                                                                                           
[23828] "IGF1_Gene"                                                                                                                                                            
[23829] "IGF2_Gene"                                                                                                                                                            
[23830] "IGF2R_Gene"                                                                                                                                                           
[23831] "IGFBP3_Gene"                                                                                                                                                          
[23832] "IGFBP4_Gene"                                                                                                                                                          
[23833] "IGFBP5_Gene"                                                                                                                                                          
[23834] "IGFBP6_Gene"                                                                                                                                                          
[23835] "IL10RB_Gene"                                                                                                                                                          
[23836] "IL11RA_Gene"                                                                                                                                                          
[23837] "IL12A_Gene"                                                                                                                                                           
[23838] "IL12B_Gene"                                                                                                                                                           
[23839] "IL13_Gene"                                                                                                                                                            
[23840] "IL17C_Gene"                                                                                                                                                           
[23841] "IL2_Gene"                                                                                                                                                             
[23842] "IL2RB_Gene"                                                                                                                                                           
[23843] "IL2RG_Gene"                                                                                                                                                           
[23844] "IL4R_Gene"                                                                                                                                                            
[23845] "IL5_Gene"                                                                                                                                                             
[23846] "IL5RA_Gene"                                                                                                                                                           
[23847] "IL6_Gene"                                                                                                                                                             
[23848] "IL6ST_Gene"                                                                                                                                                           
[23849] "IL7R_Gene"                                                                                                                                                            
[23850] "IL8_Gene"                                                                                                                                                             
[23851] "IL8RA_Gene"                                                                                                                                                           
[23852] "IL8RB_Gene"                                                                                                                                                           
[23853] "ILK_Gene"                                                                                                                                                             
[23854] "ING1_Gene"                                                                                                                                                            
[23855] "INHA_Gene"                                                                                                                                                            
[23856] "INHBA_Gene"                                                                                                                                                           
[23857] "INS_Gene"                                                                                                                                                             
[23858] "INSL4_Gene"                                                                                                                                                           
[23859] "INSR_Gene"                                                                                                                                                            
[23860] "INSRR_Gene"                                                                                                                                                           
[23861] "IRAK1_Gene"                                                                                                                                                           
[23862] "IRAK3_Gene"                                                                                                                                                           
[23863] "IRF1_Gene"                                                                                                                                                            
[23864] "IRF2_Gene"                                                                                                                                                            
[23865] "IRS1_Gene"                                                                                                                                                            
[23866] "IRS2_Gene"                                                                                                                                                            
[23867] "IRS4_Gene"                                                                                                                                                            
[23868] "ITGB4_Gene"                                                                                                                                                           
[23869] "ITK_Gene"                                                                                                                                                             
[23870] "ITPR1_Gene"                                                                                                                                                           
[23871] "JAK1_Gene"                                                                                                                                                            
[23872] "JAK2_Gene"                                                                                                                                                            
[23873] "JAK3_Gene"                                                                                                                                                            
[23874] "JTB_Gene"                                                                                                                                                             
[23875] "KDR_Gene"                                                                                                                                                             
[23876] "KLK15_Gene"                                                                                                                                                           
[23877] "KLRB1_Gene"                                                                                                                                                           
[23878] "KLRD1_Gene"                                                                                                                                                           
[23879] "KOC1_Gene"                                                                                                                                                            
[23880] "KSR_Gene"                                                                                                                                                             
[23881] "LAF4_Gene"                                                                                                                                                            
[23882] "LAMP3_Gene"                                                                                                                                                           
[23883] "LAMR1_Gene"                                                                                                                                                           
[23884] "LATS1_Gene"                                                                                                                                                           
[23885] "LATS2_Gene"                                                                                                                                                           
[23886] "LCP2_Gene"                                                                                                                                                            
[23887] "LEFTB_Gene"                                                                                                                                                           
[23888] "LEPR_Gene"                                                                                                                                                            
[23889] "LGALS3BP_Gene"                                                                                                                                                        
[23890] "LGALS8_Gene"                                                                                                                                                          
[23891] "LGI1_Gene"                                                                                                                                                            
[23892] "LHX1_Gene"                                                                                                                                                            
[23893] "LHX2_Gene"                                                                                                                                                            
[23894] "LIF_Gene"                                                                                                                                                             
[23895] "LIFR_Gene"                                                                                                                                                            
[23896] "LIMD1_Gene"                                                                                                                                                           
[23897] "LIMK1_Gene"                                                                                                                                                           
[23898] "LIMS1_Gene"                                                                                                                                                           
[23899] "CEB1_Gene"                                                                                                                                                            
[23900] "Link-GEFII_plus_H1171Gene"                                                                                                                                            
[23901] "LOH11CR2A_Gene"                                                                                                                                                       
[23902] "LOX_Gene"                                                                                                                                                             
[23903] "LTB4R_Gene"                                                                                                                                                           
[23904] "LTBP2_Gene"                                                                                                                                                           
[23905] "LTK_Gene"                                                                                                                                                             
[23906] "LY6E_Gene"                                                                                                                                                            
[23907] "LYL1_Gene"                                                                                                                                                            
[23908] "MADD_Gene"                                                                                                                                                            
[23909] "MADH2_Gene"                                                                                                                                                           
[23910] "MADH6_Gene"                                                                                                                                                           
[23911] "MADH7_Gene"                                                                                                                                                           
[23912] "MADHIP_Gene"                                                                                                                                                          
[23913] "MAGED1_Gene"                                                                                                                                                          
[23914] "MAP2K6_Gene"                                                                                                                                                          
[23915] "MAP3K1_Gene"                                                                                                                                                          
[23916] "MAP3K14_Gene"                                                                                                                                                         
[23917] "MAP3K7_Gene"                                                                                                                                                          
[23918] "MAP3K7IP1_Gene"                                                                                                                                                       
[23919] "MAP4K4_Gene"                                                                                                                                                          
[23920] "MAPK10_Gene"                                                                                                                                                          
[23921] "MAPK11_Gene"                                                                                                                                                          
[23922] "MAPK12_Gene"                                                                                                                                                          
[23923] "MAPK13_Gene"                                                                                                                                                          
[23924] "MAPK14_Gene"                                                                                                                                                          
[23925] "MAPK4_Gene"                                                                                                                                                           
[23926] "MAPK6_Gene"                                                                                                                                                           
[23927] "MAPK7_Gene"                                                                                                                                                           
[23928] "MAPK9_Gene"                                                                                                                                                           
[23929] "MAPRE1_Gene"                                                                                                                                                          
[23930] "MATK_Gene"                                                                                                                                                            
[23931] "MCT-1_Gene"                                                                                                                                                           
[23932] "MDK_Gene"                                                                                                                                                             
[23933] "MEIS1_Gene"                                                                                                                                                           
[23934] "MERTK_Gene"                                                                                                                                                           
[23935] "MFGE8_Gene"                                                                                                                                                           
[23936] "MFHAS1_Gene"                                                                                                                                                          
[23937] "MFNG_Gene"                                                                                                                                                            
[23938] "MGP_Gene"                                                                                                                                                             
[23939] "MIF_Gene"                                                                                                                                                             
[23940] "CXCL9_Gene"                                                                                                                                                           
[23941] "MKNK1_Gene"                                                                                                                                                           
[23942] "MKPX_Gene"                                                                                                                                                            
[23943] "MLL2_Gene"                                                                                                                                                            
[23944] "MLLT1_Gene"                                                                                                                                                           
[23945] "MLLT2_Gene"                                                                                                                                                           
[23946] "MLLT3_Gene"                                                                                                                                                           
[23947] "MLLT4_Gene"                                                                                                                                                           
[23948] "MLLT6_Gene"                                                                                                                                                           
[23949] "MLLT7_Gene"                                                                                                                                                           
[23950] "MME_Gene"                                                                                                                                                             
[23951] "MMP11_Gene"                                                                                                                                                           
[23952] "MPP1_Gene"                                                                                                                                                            
[23953] "MPP2_Gene"                                                                                                                                                            
[23954] "MPP3_Gene"                                                                                                                                                            
[23955] "MPZL1_Gene"                                                                                                                                                           
[23956] "MRAS_Gene"                                                                                                                                                            
[23957] "MRVI1_Gene"                                                                                                                                                           
[23958] "MSC_Gene"                                                                                                                                                             
[23959] "MST1R_Gene"                                                                                                                                                           
[23960] "MTCP1_Gene"                                                                                                                                                           
[23961] "MUSK_Gene"                                                                                                                                                            
[23962] "MXI1_Gene"                                                                                                                                                            
[23963] "MYBBP1A_Gene"                                                                                                                                                         
[23964] "N33_Gene"                                                                                                                                                             
[23965] "NAG_Gene"                                                                                                                                                             
[23966] "NCK2_Gene"                                                                                                                                                            
[23967] "NCYM_Gene"                                                                                                                                                            
[23968] "NDRG1_Gene"                                                                                                                                                           
[23969] "NEO1_Gene"                                                                                                                                                            
[23970] "NEURL_Gene"                                                                                                                                                           
[23971] "NGFR_Gene"                                                                                                                                                            
[23972] "NGFRAP1_Gene"                                                                                                                                                         
[23973] "NKX2H_Gene"                                                                                                                                                           
[23974] "NKX3-1_Gene"                                                                                                                                                          
[23975] "NMA_Gene"                                                                                                                                                             
[23976] "NMBR_Gene"                                                                                                                                                            
[23977] "NMI_Gene"                                                                                                                                                             
[23978] "NMU_Gene"                                                                                                                                                             
[23979] "NOTCH1_Gene"                                                                                                                                                          
[23980] "NPR2_Gene"                                                                                                                                                            
[23981] "NR1_Gene"                                                                                                                                                             
[23982] "NRBP_Gene"                                                                                                                                                            
[23983] "NRCAM_Gene"                                                                                                                                                           
[23984] "NRG2_Gene"                                                                                                                                                            
[23985] "NRP1_Gene"                                                                                                                                                            
[23986] "NRTN_Gene"                                                                                                                                                            
[23987] "NTF3_Gene"                                                                                                                                                            
[23988] "NTN1_Gene"                                                                                                                                                            
[23989] "NTRK2_Gene"                                                                                                                                                           
[23990] "NTRK3_Gene"                                                                                                                                                           
[23991] "NUMA1_Gene"                                                                                                                                                           
[23992] "NUP214_Gene"                                                                                                                                                          
[23993] "OR1G1_Gene"                                                                                                                                                           
[23994] "OS4_Gene"                                                                                                                                                             
[23995] "OSMR_Gene"                                                                                                                                                            
[23996] "P37NB_Gene"                                                                                                                                                           
[23997] "PAG_Gene"                                                                                                                                                             
[23998] "PAK6_Gene"                                                                                                                                                            
[23999] "PARD6A_Gene"                                                                                                                                                          
[24000] "PAWR_Gene"                                                                                                                                                            
[24001] "PAX3_Gene"                                                                                                                                                            
[24002] "PAX5_Gene"                                                                                                                                                            
[24003] "PAX7_Gene"                                                                                                                                                            
[24004] "PBEF_Gene"                                                                                                                                                            
[24005] "PBX3_Gene"                                                                                                                                                            
[24006] "PCTK1_Gene"                                                                                                                                                           
[24007] "PDC_Gene"                                                                                                                                                             
[24008] "PDGFA_Gene"                                                                                                                                                           
[24009] "PDGFRA_Gene"                                                                                                                                                          
[24010] "PDGFRB_Gene"                                                                                                                                                          
[24011] "PDGFRL_Gene"                                                                                                                                                          
[24012] "PDPK1_Gene"                                                                                                                                                           
[24013] "PGF_Gene"                                                                                                                                                             
[24014] "PIAS3_Gene"                                                                                                                                                           
[24015] "PIK3CB_Gene"                                                                                                                                                          
[24016] "PIK3CG_Gene"                                                                                                                                                          
[24017] "PIK3R3_Gene"                                                                                                                                                          
[24018] "PIK4CB_Gene"                                                                                                                                                          
[24019] "PIP5K2A_Gene"                                                                                                                                                         
[24020] "PIP5K2B_Gene"                                                                                                                                                         
[24021] "PLA2G2A_Gene"                                                                                                                                                         
[24022] "PLAB_Gene"                                                                                                                                                            
[24023] "PLAGL1_Gene"                                                                                                                                                          
[24024] "PLAUR_Gene"                                                                                                                                                           
[24025] "PLCB3_Gene"                                                                                                                                                           
[24026] "PLK_Gene"                                                                                                                                                             
[24027] "PLU-1_Gene"                                                                                                                                                           
[24028] "PMAIP1_Gene"                                                                                                                                                          
[24029] "PML_Gene"                                                                                                                                                             
[24030] "POV1_Gene"                                                                                                                                                            
[24031] "PPAP2A_Gene"                                                                                                                                                          
[24032] "PPARG_Gene"                                                                                                                                                           
[24033] "PPP1CA_Gene"                                                                                                                                                          
[24034] "PPP2R1B_Gene"                                                                                                                                                         
[24035] "PRDM1_Gene"                                                                                                                                                           
[24036] "PRDM4_Gene"                                                                                                                                                           
[24037] "PRKCA_Gene"                                                                                                                                                           
[24038] "PRKG2_Gene"                                                                                                                                                           
[24039] "PRKR_Gene"                                                                                                                                                            
[24040] "PTCH2_Gene"                                                                                                                                                           
[24041] "PTHLH_Gene"                                                                                                                                                           
[24042] "PTK2_Gene"                                                                                                                                                            
[24043] "PTK2B_Gene"                                                                                                                                                           
[24044] "PTK6_Gene"                                                                                                                                                            
[24045] "PTK7_Gene"                                                                                                                                                            
[24046] "PTN_Gene"                                                                                                                                                             
[24047] "PTP4A1_Gene"                                                                                                                                                          
[24048] "PTPN1_Gene"                                                                                                                                                           
[24049] "PTPN12_Gene"                                                                                                                                                          
[24050] "PTPN22_Gene"                                                                                                                                                          
[24051] "PTPN6_Gene"                                                                                                                                                           
[24052] "PTPN7_Gene"                                                                                                                                                           
[24053] "PTPNS1_Gene"                                                                                                                                                          
[24054] "PTPRC_Gene"                                                                                                                                                           
[24055] "PTPRE_Gene"                                                                                                                                                           
[24056] "PTPRG_Gene"                                                                                                                                                           
[24057] "PTPRJ_Gene"                                                                                                                                                           
[24058] "PTPRR_Gene"                                                                                                                                                           
[24059] "PTPRT_Gene"                                                                                                                                                           
[24060] "RAD54B_Gene"                                                                                                                                                          
[24061] "RRAGA_Gene"                                                                                                                                                           
[24062] "RAGE_Gene"                                                                                                                                                            
[24063] "RAI3_Gene"                                                                                                                                                            
[24064] "RALGDS_Gene"                                                                                                                                                          
[24065] "RANGAP1_Gene"                                                                                                                                                         
[24066] "RAP1A_Gene"                                                                                                                                                           
[24067] "RARB_Gene"                                                                                                                                                            
[24068] "RARRES3_Gene"                                                                                                                                                         
[24069] "RASD1_Gene"                                                                                                                                                           
[24070] "RBBP9_Gene"                                                                                                                                                           
[24071] "RBL2_Gene"                                                                                                                                                            
[24072] "RBM5_Gene"                                                                                                                                                            
[24073] "RBM6_Gene"                                                                                                                                                            
[24074] "RBX1_Gene"                                                                                                                                                            
[24075] "RCN2_Gene"                                                                                                                                                            
[24076] "RFP_Gene"                                                                                                                                                             
[24077] "RFP2_Gene"                                                                                                                                                            
[24078] "RGS1_Gene"                                                                                                                                                            
[24079] "RGS19_Gene"                                                                                                                                                           
[24080] "RGS2_Gene"                                                                                                                                                            
[24081] "RGS3_Gene"                                                                                                                                                            
[24082] "RHOK_Gene"                                                                                                                                                            
[24083] "RIL_Gene"                                                                                                                                                             
[24084] "RIPK2_Gene"                                                                                                                                                           
[24085] "RIPK3_Gene"                                                                                                                                                           
[24086] "RNF11_Gene"                                                                                                                                                           
[24087] "ROCK1_Gene"                                                                                                                                                           
[24088] "ROR1_Gene"                                                                                                                                                            
[24089] "ROR2_Gene"                                                                                                                                                            
[24090] "RORA_Gene"                                                                                                                                                            
[24091] "RPL10_Gene"                                                                                                                                                           
[24092] "RPL7A_Gene"                                                                                                                                                           
[24093] "RPS19_Gene"                                                                                                                                                           
[24094] "RPS27_Gene"                                                                                                                                                           
[24095] "RPS3_Gene"                                                                                                                                                            
[24096] "RPS6KA5_Gene"                                                                                                                                                         
[24097] "RPS6KB2_Gene"                                                                                                                                                         
[24098] "RRAS2_Gene"                                                                                                                                                           
[24099] "RRP22_Gene"                                                                                                                                                           
[24100] "RSU1_Gene"                                                                                                                                                            
[24101] "RYK_Gene"                                                                                                                                                             
[24102] "S100A11_Gene"                                                                                                                                                         
[24103] "S100A12_Gene"                                                                                                                                                         
[24104] "S100A8_Gene"                                                                                                                                                          
[24105] "S100A9_Gene"                                                                                                                                                          
[24106] "S100P_Gene"                                                                                                                                                           
[24107] "SCAP2_Gene"                                                                                                                                                           
[24108] "SCTR_Gene"                                                                                                                                                            
[24109] "CCL1_Gene"                                                                                                                                                            
[24110] "CCL11_Gene"                                                                                                                                                           
[24111] "CCL13_Gene"                                                                                                                                                           
[24112] "CCL14_Gene"                                                                                                                                                           
[24113] "CCL15_Gene"                                                                                                                                                           
[24114] "CCL17_Gene"                                                                                                                                                           
[24115] "CCL18_Gene"                                                                                                                                                           
[24116] "CCL19_Gene"                                                                                                                                                           
[24117] "CCL20_Gene"                                                                                                                                                           
[24118] "CCL21_Gene"                                                                                                                                                           
[24119] "CCL22_Gene"                                                                                                                                                           
[24120] "CCL23_Gene"                                                                                                                                                           
[24121] "CCL24_Gene"                                                                                                                                                           
[24122] "CCL25_Gene"                                                                                                                                                           
[24123] "CCL26_Gene"                                                                                                                                                           
[24124] "CCL27_Gene"                                                                                                                                                           
[24125] "CCL3_Gene"                                                                                                                                                            
[24126] "CCL3L1_Gene"                                                                                                                                                          
[24127] "CCL4_Gene"                                                                                                                                                            
[24128] "CCL5_Gene"                                                                                                                                                            
[24129] "CCL7_Gene"                                                                                                                                                            
[24130] "CCL8_Gene"                                                                                                                                                            
[24131] "CXCL10_Gene"                                                                                                                                                          
[24132] "CXCL11_Gene"                                                                                                                                                          
[24133] "CXCL13_Gene"                                                                                                                                                          
[24134] "CXCL14_Gene"                                                                                                                                                          
[24135] "CXCL5_Gene"                                                                                                                                                           
[24136] "CXCL6_Gene"                                                                                                                                                           
[24137] "XCL1_Gene"                                                                                                                                                            
[24138] "XCL2_Gene"                                                                                                                                                            
[24139] "CX3CL1_Gene"                                                                                                                                                          
[24140] "CXCL12_Gene"                                                                                                                                                          
[24141] "SECTM1_Gene"                                                                                                                                                          
[24142] "SEMA3E_Gene"                                                                                                                                                          
[24143] "SERPINI2_Gene"                                                                                                                                                        
[24144] "SET_Gene"                                                                                                                                                             
[24145] "SETDB1_Gene"                                                                                                                                                          
[24146] "SFN_Gene"                                                                                                                                                             
[24147] "SFRP4_Gene"                                                                                                                                                           
[24148] "SH2B_Gene"                                                                                                                                                            
[24149] "SH2D3A_Gene"                                                                                                                                                          
[24150] "SH2D3C_Gene"                                                                                                                                                          
[24151] "SHC1_Gene"                                                                                                                                                            
[24152] "SHC3_Gene"                                                                                                                                                            
[24153] "SHH_Gene"                                                                                                                                                             
[24154] "SIRPB1_Gene"                                                                                                                                                          
[24155] "SKIL_Gene"                                                                                                                                                            
[24156] "SKIV2L_Gene"                                                                                                                                                          
[24157] "SKP2_Gene"                                                                                                                                                            
[24158] "SLC26A3_Gene"                                                                                                                                                         
[24159] "SLI_Gene"                                                                                                                                                             
[24160] "SMO_Gene"                                                                                                                                                             
[24161] "SNK_Gene"                                                                                                                                                             
[24162] "FRS2_Gene"                                                                                                                                                            
[24163] "FRS3_Gene"                                                                                                                                                            
[24164] "SNW1_Gene"                                                                                                                                                            
[24165] "SRP19_Gene"                                                                                                                                                           
[24166] "SRPUL_Gene"                                                                                                                                                           
[24167] "SSH3BP1_Gene"                                                                                                                                                         
[24168] "SSPN_Gene"                                                                                                                                                            
[24169] "SST_Gene"                                                                                                                                                             
[24170] "SSTR1_Gene"                                                                                                                                                           
[24171] "SSTR3_Gene"                                                                                                                                                           
[24172] "SSTR4_Gene"                                                                                                                                                           
[24173] "ST13_Gene"                                                                                                                                                            
[24174] "STAT1_Gene"                                                                                                                                                           
[24175] "STAT2_Gene"                                                                                                                                                           
[24176] "STAT3_Gene"                                                                                                                                                           
[24177] "STAT5A_Gene"                                                                                                                                                          
[24178] "STAT6_Gene"                                                                                                                                                           
[24179] "STC1_Gene"                                                                                                                                                            
[24180] "STC2_Gene"                                                                                                                                                            
[24181] "STK15_Gene"                                                                                                                                                           
[24182] "STK6_Gene"                                                                                                                                                            
[24183] "SUI1_Gene"                                                                                                                                                            
[24184] "TACC3_Gene"                                                                                                                                                           
[24185] "TACR3_Gene"                                                                                                                                                           
[24186] "TAL2_Gene"                                                                                                                                                            
[24187] "TAZ_Gene"                                                                                                                                                             
[24188] "TBK1_Gene"                                                                                                                                                            
[24189] "TCF3_Gene"                                                                                                                                                            
[24190] "TCF7L2_Gene"                                                                                                                                                          
[24191] "TCL1B_Gene"                                                                                                                                                           
[24192] "TCTA_Gene"                                                                                                                                                            
[24193] "TEC_Gene"                                                                                                                                                             
[24194] "TEK_Gene"                                                                                                                                                             
[24195] "TFAP2C_Gene"                                                                                                                                                          
[24196] "TFDP2_Gene"                                                                                                                                                           
[24197] "TFE3_Gene"                                                                                                                                                            
[24198] "TGFA_Gene"                                                                                                                                                            
[24199] "TGFB1_Gene"                                                                                                                                                           
[24200] "TGFB2_Gene"                                                                                                                                                           
[24201] "TGFBI_Gene"                                                                                                                                                           
[24202] "TGFBR1_Gene"                                                                                                                                                          
[24203] "TGFBR3_Gene"                                                                                                                                                          
[24204] "TIE_Gene"                                                                                                                                                             
[24205] "TLR1_Gene"                                                                                                                                                            
[24206] "TLR2_Gene"                                                                                                                                                            
[24207] "TLR3_Gene"                                                                                                                                                            
[24208] "TLR4_Gene"                                                                                                                                                            
[24209] "TLR5_Gene"                                                                                                                                                            
[24210] "TLR6_Gene"                                                                                                                                                            
[24211] "TLR7_Gene"                                                                                                                                                            
[24212] "TLR8_Gene"                                                                                                                                                            
[24213] "TLX1_Gene"                                                                                                                                                            
[24214] "TMPRSS2_Gene"                                                                                                                                                         
[24215] "TNFRSF11B_Gene"                                                                                                                                                       
[24216] "TNFRSF6B_Gene"                                                                                                                                                        
[24217] "TNFSF11_Gene"                                                                                                                                                         
[24218] "TNK1_Gene"                                                                                                                                                            
[24219] "TOLLIP_Gene"                                                                                                                                                          
[24220] "TPD52_Gene"                                                                                                                                                           
[24221] "TPD52L1_Gene"                                                                                                                                                         
[24222] "TRPM5_Gene"                                                                                                                                                           
[24223] "TRRAP_Gene"                                                                                                                                                           
[24224] "TSHR_Gene"                                                                                                                                                            
[24225] "TSKS_Gene"                                                                                                                                                            
[24226] "TSLP_Gene"                                                                                                                                                            
[24227] "TSPY_Gene"                                                                                                                                                            
[24228] "TTC4_Gene"                                                                                                                                                            
[24229] "TTK_Gene"                                                                                                                                                             
[24230] "CXCR6_Gene"                                                                                                                                                           
[24231] "TYRO3_Gene"                                                                                                                                                           
[24232] "TYROBP_Gene"                                                                                                                                                          
[24233] "UBE2D2_Gene"                                                                                                                                                          
[24234] "UNC13_Gene"                                                                                                                                                           
[24235] "USP6_Gene"                                                                                                                                                            
[24236] "USP8_Gene"                                                                                                                                                            
[24237] "VAV3_Gene"                                                                                                                                                            
[24238] "_10p11_1"                                                                                                                                                             
[24239] "_10p11_23"                                                                                                                                                            
[24240] "_10p12"                                                                                                                                                               
[24241] "_10p12_3-p11_2"                                                                                                                                                       
[24242] "_10p12_31"                                                                                                                                                            
[24243] "_10q11_1"                                                                                                                                                             
[24244] "_10q11_21"                                                                                                                                                            
[24245] "_10q24-q25"                                                                                                                                                           
[24246] "_10q24-qter"                                                                                                                                                          
[24247] "_10q24_31"                                                                                                                                                            
[24248] "_10q25"                                                                                                                                                               
[24249] "_10q25_1"                                                                                                                                                             
[24250] "_10q25_3"                                                                                                                                                             
[24251] "_10q25_3-q26_1"                                                                                                                                                       
[24252] "_10q26_13"                                                                                                                                                            
[24253] "_10q26_13-q26_3"                                                                                                                                                      
[24254] "_11p11_2-p11_1"                                                                                                                                                       
[24255] "_11p12"                                                                                                                                                               
[24256] "_11p12-p11_2"                                                                                                                                                         
[24257] "_11p13-p12"                                                                                                                                                           
[24258] "_11p14_3"                                                                                                                                                             
[24259] "_11p15_2"                                                                                                                                                             
[24260] "_11p15_5-p15_4"                                                                                                                                                       
[24261] "_11q12_2"                                                                                                                                                             
[24262] "_11q13_2"                                                                                                                                                             
[24263] "_11q13_3-q13_5"                                                                                                                                                       
[24264] "_11q13_4"                                                                                                                                                             
[24265] "_11q14_2"                                                                                                                                                             
[24266] "_11q14_2-q14_3"                                                                                                                                                       
[24267] "_11q23-q24"                                                                                                                                                           
[24268] "_11q24-q24"                                                                                                                                                           
[24269] "_12p11_2"                                                                                                                                                             
[24270] "_12p12_1-p11_2"                                                                                                                                                       
[24271] "_12p13-p12_3"                                                                                                                                                         
[24272] "_12p13_1-p12_3"                                                                                                                                                       
[24273] "_12q12"                                                                                                                                                               
[24274] "_12q12-q14"                                                                                                                                                           
[24275] "_12q13-q15"                                                                                                                                                           
[24276] "_12q13_13"                                                                                                                                                            
[24277] "_12q14-q15"                                                                                                                                                           
[24278] "_12q21"                                                                                                                                                               
[24279] "_12q23-q24"                                                                                                                                                           
[24280] "_12q23-q24_1"                                                                                                                                                         
[24281] "_12q24_1"                                                                                                                                                             
[24282] "_12q24_11"                                                                                                                                                            
[24283] "_12q24_13"                                                                                                                                                            
[24284] "_12q24_31"                                                                                                                                                            
[24285] "_13q11-q12"                                                                                                                                                           
[24286] "_13q12-13"                                                                                                                                                            
[24287] "_13q14_1"                                                                                                                                                             
[24288] "_13q14_12-q14_2"                                                                                                                                                      
[24289] "_13q34"                                                                                                                                                               
[24290] "_14q13_1"                                                                                                                                                             
[24291] "_14q22"                                                                                                                                                               
[24292] "_14q23-q24_1"                                                                                                                                                         
[24293] "_14q31-q32_1"                                                                                                                                                         
[24294] "_14q32_1"                                                                                                                                                             
[24295] "_14q32_1-q32_2"                                                                                                                                                       
[24296] "_14q32_33"                                                                                                                                                            
[24297] "_15q14"                                                                                                                                                               
[24298] "_15q15_1-q21_1"                                                                                                                                                       
[24299] "_15q21"                                                                                                                                                               
[24300] "_15q22"                                                                                                                                                               
[24301] "_15q22_3-q23"                                                                                                                                                         
[24302] "_15q23"                                                                                                                                                               
[24303] "_15q25"                                                                                                                                                               
[24304] "_16p11_2-12_1"                                                                                                                                                        
[24305] "_16p11_2-p11_1"                                                                                                                                                       
[24306] "_16q12_2"                                                                                                                                                             
[24307] "_16q22_2-q22_3"                                                                                                                                                       
[24308] "_16q24"                                                                                                                                                               
[24309] "_17p11_1"                                                                                                                                                             
[24310] "_17p11_2"                                                                                                                                                             
[24311] "_17p13"                                                                                                                                                               
[24312] "_17q11-qter"                                                                                                                                                          
[24313] "_17q11_1"                                                                                                                                                             
[24314] "_17q12-q21"                                                                                                                                                           
[24315] "_17q21-q22"                                                                                                                                                           
[24316] "_17q21_1-q21_3"                                                                                                                                                       
[24317] "_17q22-q23_2"                                                                                                                                                         
[24318] "_17q22-qter"                                                                                                                                                          
[24319] "_17q24-q25"                                                                                                                                                           
[24320] "_17q25_1"                                                                                                                                                             
[24321] "_17q25_3"                                                                                                                                                             
[24322] "_18q11_1"                                                                                                                                                             
[24323] "_18q12-q21"                                                                                                                                                           
[24324] "_18q21_31"                                                                                                                                                            
[24325] "_19p13_1-13_2"                                                                                                                                                        
[24326] "_19q13_1-qter"                                                                                                                                                        
[24327] "_19q13_4"                                                                                                                                                             
[24328] "_19q13_41"                                                                                                                                                            
[24329] "_19q13_42"                                                                                                                                                            
[24330] "_1p13_2"                                                                                                                                                              
[24331] "_1p13_3-p13_1"                                                                                                                                                        
[24332] "_1p21"                                                                                                                                                                
[24333] "_1p31_2-p31_1"                                                                                                                                                        
[24334] "_1p31_3"                                                                                                                                                              
[24335] "_1p32_3"                                                                                                                                                              
[24336] "_1p32_3-p31_3"                                                                                                                                                        
[24337] "_1p33"                                                                                                                                                                
[24338] "_1p33-p32"                                                                                                                                                            
[24339] "_1p33-p34"                                                                                                                                                            
[24340] "_1p34-p33"                                                                                                                                                            
[24341] "_1p34_1"                                                                                                                                                              
[24342] "_1p35-p34_2"                                                                                                                                                          
[24343] "_1p35_3"                                                                                                                                                              
[24344] "_1p36_1-p35"                                                                                                                                                          
[24345] "_1p36_12"                                                                                                                                                             
[24346] "_1p36_2-p36_12"                                                                                                                                                       
[24347] "_1p36_33"                                                                                                                                                             
[24348] "_1pter-p22_1"                                                                                                                                                         
[24349] "_1q12-q23"                                                                                                                                                            
[24350] "_1q23_2"                                                                                                                                                              
[24351] "_1q25-q31_1"                                                                                                                                                          
[24352] "_1q31"                                                                                                                                                                
[24353] "_1q31-q32"                                                                                                                                                            
[24354] "_1q32_1"                                                                                                                                                              
[24355] "_1q41-q42"                                                                                                                                                            
[24356] "_1q42_1-q42_2"                                                                                                                                                        
[24357] "_20p11"                                                                                                                                                               
[24358] "_20p11_2"                                                                                                                                                             
[24359] "_20p13"                                                                                                                                                               
[24360] "_20q11_1-11_23"                                                                                                                                                       
[24361] "_20q13_1-q13_2"                                                                                                                                                       
[24362] "_21q22_11"                                                                                                                                                            
[24363] "_22q11_22"                                                                                                                                                            
[24364] "_22q13_2"                                                                                                                                                             
[24365] "_22q13_33"                                                                                                                                                            
[24366] "_2p13"                                                                                                                                                                
[24367] "_2p14_1"                                                                                                                                                              
[24368] "_2p23_3-p23_2"                                                                                                                                                        
[24369] "_2p24"                                                                                                                                                                
[24370] "_2p24_3-q21_3"                                                                                                                                                        
[24371] "_2q11_2-q12"                                                                                                                                                          
[24372] "_2q12"                                                                                                                                                                
[24373] "_2q12-q14"                                                                                                                                                            
[24374] "_2q12_2"                                                                                                                                                              
[24375] "_2q14_1"                                                                                                                                                              
[24376] "_2q22-q24"                                                                                                                                                            
[24377] "_2q22_2-q23_3"                                                                                                                                                        
[24378] "_2q23-q24"                                                                                                                                                            
[24379] "_2q32_2"                                                                                                                                                              
[24380] "_2q35-q37"                                                                                                                                                            
[24381] "_2q36"                                                                                                                                                                
[24382] "_2q36-q37"                                                                                                                                                            
[24383] "_2q36_3"                                                                                                                                                              
[24384] "_2q37_1"                                                                                                                                                              
[24385] "_3p12-q13_2"                                                                                                                                                          
[24386] "_3p14_1"                                                                                                                                                              
[24387] "_3p24"                                                                                                                                                                
[24388] "_3p26-p24"                                                                                                                                                            
[24389] "_3q21-q23"                                                                                                                                                            
[24390] "_3q21-qter"                                                                                                                                                           
[24391] "_3q22"                                                                                                                                                                
[24392] "_3q23"                                                                                                                                                                
[24393] "_3q24"                                                                                                                                                                
[24394] "_3q25_1-q25_2"                                                                                                                                                        
[24395] "_3q26_1-q26_2"                                                                                                                                                        
[24396] "_3q28"                                                                                                                                                                
[24397] "_3q29"                                                                                                                                                                
[24398] "_4p12"                                                                                                                                                                
[24399] "_4p14"                                                                                                                                                                
[24400] "_4p15_1"                                                                                                                                                              
[24401] "_4p16_1"                                                                                                                                                              
[24402] "_4q11"                                                                                                                                                                
[24403] "_4q13_1-q21_1"                                                                                                                                                        
[24404] "_4q13_3"                                                                                                                                                              
[24405] "_4q21_1"                                                                                                                                                              
[24406] "_4q21_3"                                                                                                                                                              
[24407] "_4q22_1-q23"                                                                                                                                                          
[24408] "_4q26-q27"                                                                                                                                                            
[24409] "_4q28-q32"                                                                                                                                                            
[24410] "_4q32"                                                                                                                                                                
[24411] "_4q34_1-q35_1"                                                                                                                                                        
[24412] "_4q35"                                                                                                                                                                
[24413] "_5p13"                                                                                                                                                                
[24414] "_5p13-p12"                                                                                                                                                            
[24415] "_5p13_1"                                                                                                                                                              
[24416] "_5q11"                                                                                                                                                                
[24417] "_5q11_2"                                                                                                                                                              
[24418] "_5q12_1-q13_2"                                                                                                                                                        
[24419] "_5q12_3"                                                                                                                                                              
[24420] "_5q21_3"                                                                                                                                                              
[24421] "_5q23-q33"                                                                                                                                                            
[24422] "_5q23_2"                                                                                                                                                              
[24423] "_5q31-q32"                                                                                                                                                            
[24424] "_5q31_1-q33_1"                                                                                                                                                        
[24425] "_5q31_3"                                                                                                                                                              
[24426] "_5q33_1-qter"                                                                                                                                                         
[24427] "_5q34"                                                                                                                                                                
[24428] "_5q34-q35"                                                                                                                                                            
[24429] "_5q35_2"                                                                                                                                                              
[24430] "_6p21_1-p12_2"                                                                                                                                                        
[24431] "_6p21_3-p21_2"                                                                                                                                                        
[24432] "_6p22"                                                                                                                                                                
[24433] "_6p23"                                                                                                                                                                
[24434] "_6q12"                                                                                                                                                                
[24435] "_6q13-q21"                                                                                                                                                            
[24436] "_6q16_1-q16_3"                                                                                                                                                        
[24437] "_6q21-q22_1"                                                                                                                                                          
[24438] "_6q21-q22_3"                                                                                                                                                          
[24439] "_6q21-qter"                                                                                                                                                           
[24440] "_6q22_33"                                                                                                                                                             
[24441] "_6q24"                                                                                                                                                                
[24442] "_6q24-q25_1"                                                                                                                                                          
[24443] "_6q26"                                                                                                                                                                
[24444] "_7p11"                                                                                                                                                                
[24445] "_7p12_1"                                                                                                                                                              
[24446] "_7p13-p12"                                                                                                                                                            
[24447] "_7p14_1"                                                                                                                                                              
[24448] "_7p15-p13"                                                                                                                                                            
[24449] "_7p21"                                                                                                                                                                
[24450] "_7p21-p15"                                                                                                                                                            
[24451] "_7p22-p21"                                                                                                                                                            
[24452] "_7q11_23"                                                                                                                                                             
[24453] "_7q21_11"                                                                                                                                                             
[24454] "_7q32_3"                                                                                                                                                              
[24455] "_7q33-q34"                                                                                                                                                            
[24456] "_7q34-q35"                                                                                                                                                            
[24457] "_7q36"                                                                                                                                                                
[24458] "_8p11_21"                                                                                                                                                             
[24459] "_8p21-p11_2"                                                                                                                                                          
[24460] "_8p21_1"                                                                                                                                                              
[24461] "_8p23_2-p23_1"                                                                                                                                                        
[24462] "_8q21_3-q22"                                                                                                                                                          
[24463] "_8q22_3-q23_1"                                                                                                                                                        
[24464] "_8q24-qter"                                                                                                                                                           
[24465] "_9p12-p11"                                                                                                                                                            
[24466] "_9p13"                                                                                                                                                                
[24467] "_9p21-p12"                                                                                                                                                            
[24468] "_9p21_2"                                                                                                                                                              
[24469] "_9p22"                                                                                                                                                                
[24470] "_9p24"                                                                                                                                                                
[24471] "_9q22"                                                                                                                                                                
[24472] "_9q22_1"                                                                                                                                                              
[24473] "_9q31_3-q32"                                                                                                                                                          
[24474] "_9q32-q33"                                                                                                                                                            
[24475] "_9q33-q34"                                                                                                                                                            
[24476] "_9q33-q34_1"                                                                                                                                                          
[24477] "_9q34_13"                                                                                                                                                             
[24478] "Xp11_3-p11_23"                                                                                                                                                        
[24479] "Xp22"                                                                                                                                                                 
[24480] "Xp22_3"                                                                                                                                                               
[24481] "Xq13_1-q13_3"                                                                                                                                                         
[24482] "Xq21_33-q23"                                                                                                                                                          
[24483] "Xq22"                                                                                                                                                                 
[24484] "Xq22-24"                                                                                                                                                              
[24485] "Xq22_3"                                                                                                                                                               
[24486] "Xq25-q26"                                                                                                                                                             
[24487] "Xq27_1-q27_2"                                                                                                                                                         
[24488] "Yp11_1-q11_1"                                                                                                                                                         
[24489] "Age"                                                                                                                                                                  
[24490] "Appetite"                                                                                                                                                             
[24491] "Autopsy"                                                                                                                                                              
[24492] "Axis"                                                                                                                                                                 
[24493] "Birth"                                                                                                                                                                
[24494] "Body_Surface_Area"                                                                                                                                                    
[24495] "Capsule"                                                                                                                                                              
[24496] "Carcinoembryonic_Antigen"                                                                                                                                             
[24497] "City"                                                                                                                                                                 
[24498] "Classification"                                                                                                                                                       
[24499] "Code"                                                                                                                                                                 
[24500] "Coombs_Test"                                                                                                                                                          
[24501] "Date"                                                                                                                                                                 
[24502] "Daughter"                                                                                                                                                             
[24503] "Discharge_from_Healthcare_Facility"                                                                                                                                   
[24504] "Distance"                                                                                                                                                             
[24505] "Donor"                                                                                                                                                                
[24506] "Route"                                                                                                                                                                
[24507] "E-mail"                                                                                                                                                               
[24508] "Eligibility_Determination"                                                                                                                                            
[24509] "Employment"                                                                                                                                                           
[24510] "Family"                                                                                                                                                               
[24511] "Father"                                                                                                                                                               
[24512] "Filed"                                                                                                                                                                
[24513] "Projection"                                                                                                                                                           
[24514] "Genitalia"                                                                                                                                                            
[24515] "Health"                                                                                                                                                               
[24516] "Hospitalization"                                                                                                                                                      
[24517] "Indicator"                                                                                                                                                            
[24518] "Industry"                                                                                                                                                             
[24519] "Inpatient"                                                                                                                                                            
[24520] "Lactate_Dehydrogenase"                                                                                                                                                
[24521] "Laterality"                                                                                                                                                           
[24522] "High_Density_Lipoprotein"                                                                                                                                             
[24523] "Low_Density_Lipoprotein"                                                                                                                                              
[24524] "Marital_Status"                                                                                                                                                       
[24525] "Mother"                                                                                                                                                               
[24526] "Person"                                                                                                                                                               
[24527] "Name"                                                                                                                                                                 
[24528] "Occupation"                                                                                                                                                           
[24529] "Compliance"                                                                                                                                                           
[24530] "Pressure"                                                                                                                                                             
[24531] "Randomization"                                                                                                                                                        
[24532] "Recommendation"                                                                                                                                                       
[24533] "Record"                                                                                                                                                               
[24534] "Role"                                                                                                                                                                 
[24535] "Self"                                                                                                                                                                 
[24536] "Sensitivity"                                                                                                                                                          
[24537] "SGOT-AST_Protein"                                                                                                                                                     
[24538] "Shoulder"                                                                                                                                                             
[24539] "Sibling"                                                                                                                                                              
[24540] "Son"                                                                                                                                                                  
[24541] "Temperature"                                                                                                                                                          
[24542] "Time"                                                                                                                                                                 
[24543] "Weight"                                                                                                                                                               
[24544] "Measure"                                                                                                                                                              
[24545] "Fax"                                                                                                                                                                  
[24546] "Schedule"                                                                                                                                                             
[24547] "End_Point"                                                                                                                                                            
[24548] "Baseline"                                                                                                                                                             
[24549] "Evaluation"                                                                                                                                                           
[24550] "Karyotype"                                                                                                                                                            
[24551] "Collimator"                                                                                                                                                           
[24552] "Assessed"                                                                                                                                                             
[24553] "Procedure"                                                                                                                                                            
[24554] "Fixation"                                                                                                                                                             
[24555] "Sternotomy"                                                                                                                                                           
[24556] "Tomogram"                                                                                                                                                             
[24557] "Bronchial"                                                                                                                                                            
[24558] "Pleural"                                                                                                                                                              
[24559] "Rectal"                                                                                                                                                               
[24560] "Renal"                                                                                                                                                                
[24561] "Mesenteric"                                                                                                                                                           
[24562] "High"                                                                                                                                                                 
[24563] "Right"                                                                                                                                                                
[24564] "Left"                                                                                                                                                                 
[24565] "Lateral"                                                                                                                                                              
[24566] "Anterior"                                                                                                                                                             
[24567] "Medial"                                                                                                                                                               
[24568] "Peripheral"                                                                                                                                                           
[24569] "Internal"                                                                                                                                                             
[24570] "Superior"                                                                                                                                                             
[24571] "Proximal"                                                                                                                                                             
[24572] "Distal"                                                                                                                                                               
[24573] "Segmental"                                                                                                                                                            
[24574] "Superficial"                                                                                                                                                          
[24575] "Deep"                                                                                                                                                                 
[24576] "Horizontal"                                                                                                                                                           
[24577] "Longitudinal"                                                                                                                                                         
[24578] "Vertical"                                                                                                                                                             
[24579] "Area"                                                                                                                                                                 
[24580] "Surface"                                                                                                                                                              
[24581] "Positive"                                                                                                                                                             
[24582] "Negative"                                                                                                                                                             
[24583] "Long"                                                                                                                                                                 
[24584] "Short"                                                                                                                                                                
[24585] "Complete"                                                                                                                                                             
[24586] "Primary"                                                                                                                                                              
[24587] "Microscopic"                                                                                                                                                          
[24588] "Multifocal"                                                                                                                                                           
[24589] "Progressive"                                                                                                                                                          
[24590] "Soft"                                                                                                                                                                 
[24591] "Quantity"                                                                                                                                                             
[24592] "Phase"                                                                                                                                                                
[24593] "Most"                                                                                                                                                                 
[24594] "Mixed"                                                                                                                                                                
[24595] "Third"                                                                                                                                                                
[24596] "Medical"                                                                                                                                                              
[24597] "Neurologic"                                                                                                                                                           
[24598] "Prognostic"                                                                                                                                                           
[24599] "Carina"                                                                                                                                                               
[24600] "Upper_GI"                                                                                                                                                             
[24601] "Intestinal"                                                                                                                                                           
[24602] "Lymphatic"                                                                                                                                                            
[24603] "Infraclavicular_Region"                                                                                                                                               
[24604] "Symptomatic"                                                                                                                                                          
[24605] "Extension"                                                                                                                                                            
[24606] "Painful"                                                                                                                                                              
[24607] "Painless"                                                                                                                                                             
[24608] "Residence"                                                                                                                                                            
[24609] "Actual"                                                                                                                                                               
[24610] "Occurrence"                                                                                                                                                           
[24611] "Neural_Cell_Adhesion_Molecule"                                                                                                                                        
[24612] "Therapeutic"                                                                                                                                                          
[24613] "Fluid"                                                                                                                                                                
[24614] "Onset"                                                                                                                                                                
[24615] "Recent"                                                                                                                                                               
[24616] "Associated"                                                                                                                                                           
[24617] "Within"                                                                                                                                                               
[24618] "Quality"                                                                                                                                                              
[24619] "Type"                                                                                                                                                                 
[24620] "Diameter"                                                                                                                                                             
[24621] "Necrotic"                                                                                                                                                             
[24622] "Auer_Rod"                                                                                                                                                             
[24623] "Hairy_Cell"                                                                                                                                                           
[24624] "Brother"                                                                                                                                                              
[24625] "Adopted"                                                                                                                                                              
[24626] "Venous"                                                                                                                                                               
[24627] "Cardiovascular"                                                                                                                                                       
[24628] "SGPT-ALT_Protein"                                                                                                                                                     
[24629] "Test"                                                                                                                                                                 
[24630] "Mobile"                                                                                                                                                               
[24631] "Birth_Date"                                                                                                                                                           
[24632] "Notification"                                                                                                                                                         
[24633] "Systolic_Pressure"                                                                                                                                                    
[24634] "Diastolic_Pressure"                                                                                                                                                   
[24635] "Culture_Procedure"                                                                                                                                                    
[24636] "Day"                                                                                                                                                                  
[24637] "Granulomatous"                                                                                                                                                        
[24638] "Multicentric"                                                                                                                                                         
[24639] "Total"                                                                                                                                                                
[24640] "Examination"                                                                                                                                                          
[24641] "Side"                                                                                                                                                                 
[24642] "Contralateral"                                                                                                                                                        
[24643] "Ipsilateral"                                                                                                                                                          
[24644] "Lower"                                                                                                                                                                
[24645] "Mediastinal"                                                                                                                                                          
[24646] "Oral"                                                                                                                                                                 
[24647] "Parietal"                                                                                                                                                             
[24648] "Peritoneal"                                                                                                                                                           
[24649] "Radial"                                                                                                                                                               
[24650] "Visceral"                                                                                                                                                             
[24651] "Paraaortic"                                                                                                                                                           
[24652] "Paratracheal"                                                                                                                                                         
[24653] "Subaortic"                                                                                                                                                            
[24654] "Place"                                                                                                                                                                
[24655] "Protocol"                                                                                                                                                             
[24656] "Distant"                                                                                                                                                              
[24657] "Long-Term"                                                                                                                                                            
[24658] "Nodal"                                                                                                                                                                
[24659] "Viable"                                                                                                                                                               
[24660] "Slide"                                                                                                                                                                
[24661] "Whole"                                                                                                                                                                
[24662] "Core"                                                                                                                                                                 
[24663] "Unrelated"                                                                                                                                                            
[24664] "Supraclavicular"                                                                                                                                                      
[24665] "Duration"                                                                                                                                                             
[24666] "Progression"                                                                                                                                                          
[24667] "Extent"                                                                                                                                                               
[24668] "Depth"                                                                                                                                                                
[24669] "Length"                                                                                                                                                               
[24670] "Volume"                                                                                                                                                               
[24671] "Pattern"                                                                                                                                                              
[24672] "Number"                                                                                                                                                               
[24673] "Score"                                                                                                                                                                
[24674] "Position"                                                                                                                                                             
[24675] "Use"                                                                                                                                                                  
[24676] "Location"                                                                                                                                                             
[24677] "Abdominal"                                                                                                                                                            
[24678] "Mechanism"                                                                                                                                                            
[24679] "Paraesophageal"                                                                                                                                                       
[24680] "Width"                                                                                                                                                                
[24681] "Class"                                                                                                                                                                
[24682] "Height"                                                                                                                                                               
[24683] "Musculoskeletal"                                                                                                                                                      
[24684] "Polypectomy"                                                                                                                                                          
[24685] "Genitourinary"                                                                                                                                                        
[24686] "Reconstruction"                                                                                                                                                       
[24687] "International_Normalized_Ratio"                                                                                                                                       
[24688] "Inferior"                                                                                                                                                             
[24689] "Academic_Degree"                                                                                                                                                      
[24690] "Upper"                                                                                                                                                                
[24691] "Documented"                                                                                                                                                           
[24692] "Registrar"                                                                                                                                                            
[24693] "Attribution"                                                                                                                                                          
[24694] "Expectancy"                                                                                                                                                           
[24695] "Mutant"                                                                                                                                                               
[24696] "Performance"                                                                                                                                                          
[24697] "Success"                                                                                                                                                              
[24698] "Neural"                                                                                                                                                               
[24699] "Identifier"                                                                                                                                                           
[24700] "Description"                                                                                                                                                          
[24701] "Closure"                                                                                                                                                              
[24702] "Assessment"                                                                                                                                                           
[24703] "Member"                                                                                                                                                               
[24704] "Agreement"                                                                                                                                                            
[24705] "Exclusion"                                                                                                                                                            
[24706] "Payment"                                                                                                                                                              
[24707] "Category"                                                                                                                                                             
[24708] "Classified"                                                                                                                                                           
[24709] "Options"                                                                                                                                                              
[24710] "Report"                                                                                                                                                               
[24711] "Small"                                                                                                                                                                
[24712] "Appearance"                                                                                                                                                           
[24713] "Partial"                                                                                                                                                              
[24714] "Course"                                                                                                                                                               
[24715] "End_Date"                                                                                                                                                             
[24716] "Maiden_Name"                                                                                                                                                          
[24717] "Administered"                                                                                                                                                         
[24718] "Begin_Date"                                                                                                                                                           
[24719] "TNM"                                                                                                                                                                  
[24720] "Admission"                                                                                                                                                            
[24721] "Cytometry"                                                                                                                                                            
[24722] "Benefits"                                                                                                                                                             
[24723] "Local-Regional"                                                                                                                                                       
[24724] "Chest"                                                                                                                                                                
[24725] "Index"                                                                                                                                                                
[24726] "Analysis"                                                                                                                                                             
[24727] "Manufacturer_Name"                                                                                                                                                    
[24728] "Comments"                                                                                                                                                             
[24729] "Pill"                                                                                                                                                                 
[24730] "Telephone"                                                                                                                                                            
[24731] "Access"                                                                                                                                                               
[24732] "Application"                                                                                                                                                          
[24733] "Clinical"                                                                                                                                                             
[24734] "Pelvic"                                                                                                                                                               
[24735] "Zubrod_Performance_Status"                                                                                                                                            
[24736] "Abnormal"                                                                                                                                                             
[24737] "Accession_Number"                                                                                                                                                     
[24738] "Accrual"                                                                                                                                                              
[24739] "Action"                                                                                                                                                               
[24740] "Activation_Date"                                                                                                                                                      
[24741] "Additional"                                                                                                                                                           
[24742] "Address"                                                                                                                                                              
[24743] "Adjacent"                                                                                                                                                             
[24744] "Administration"                                                                                                                                                       
[24745] "Adverse_Drug_Experience_Report"                                                                                                                                       
[24746] "Advanced"                                                                                                                                                             
[24747] "Affiliate"                                                                                                                                                            
[24748] "Affiliated"                                                                                                                                                           
[24749] "Aliquot"                                                                                                                                                              
[24750] "Alternative"                                                                                                                                                          
[24751] "Amended"                                                                                                                                                              
[24752] "Amount"                                                                                                                                                               
[24753] "Amplification"                                                                                                                                                        
[24754] "Anal_Verge"                                                                                                                                                           
[24755] "Analyzed"                                                                                                                                                             
[24756] "Anatomic"                                                                                                                                                             
[24757] "Anterolateral"                                                                                                                                                        
[24758] "Apical"                                                                                                                                                               
[24759] "Approach"                                                                                                                                                             
[24760] "Approved"                                                                                                                                                             
[24761] "Assignment"                                                                                                                                                           
[24762] "At"                                                                                                                                                                   
[24763] "Atypical"                                                                                                                                                             
[24764] "Available"                                                                                                                                                            
[24765] "Basis"                                                                                                                                                                
[24766] "Begin"                                                                                                                                                                
[24767] "Best"                                                                                                                                                                 
[24768] "Bimanual"                                                                                                                                                             
[24769] "Biochemical"                                                                                                                                                          
[24770] "Biphasic"                                                                                                                                                             
[24771] "Blocks"                                                                                                                                                               
[24772] "Bone_Marrow_Stem_Cell_Transplantation"                                                                                                                                
[24773] "Boost"                                                                                                                                                                
[24774] "Anatomic_Border"                                                                                                                                                      
[24775] "Bottom"                                                                                                                                                               
[24776] "Calcified"                                                                                                                                                            
[24777] "Cancer_and_Leukemia_Group_B"                                                                                                                                          
[24778] "Capacity"                                                                                                                                                             
[24779] "Cavity"                                                                                                                                                               
[24780] "Center"                                                                                                                                                               
[24781] "Change"                                                                                                                                                               
[24782] "Characteristics"                                                                                                                                                      
[24783] "Clinical_Radiologic"                                                                                                                                                  
[24784] "Closest"                                                                                                                                                              
[24785] "Coated"                                                                                                                                                               
[24786] "Childrens_Oncology_Group"                                                                                                                                             
[24787] "Collected"                                                                                                                                                            
[24788] "Collection"                                                                                                                                                           
[24789] "Combined"                                                                                                                                                             
[24790] "Complicating"                                                                                                                                                         
[24791] "Concurrent"                                                                                                                                                           
[24792] "Condition"                                                                                                                                                            
[24793] "Confirmed"                                                                                                                                                            
[24794] "Congestive"                                                                                                                                                           
[24795] "Consent"                                                                                                                                                              
[24796] "Contact"                                                                                                                                                              
[24797] "Coordinating"                                                                                                                                                         
[24798] "Count"                                                                                                                                                                
[24799] "Country"                                                                                                                                                              
[24800] "Clinical_Research_Associate"                                                                                                                                          
[24801] "Criteria"                                                                                                                                                             
[24802] "Critical"                                                                                                                                                             
[24803] "Common_Toxicity_Criteria"                                                                                                                                             
[24804] "Cumulative"                                                                                                                                                           
[24805] "Current"                                                                                                                                                              
[24806] "Cycle"                                                                                                                                                                
[24807] "Daily"                                                                                                                                                                
[24808] "Data"                                                                                                                                                                 
[24809] "Declining"                                                                                                                                                            
[24810] "Delay"                                                                                                                                                                
[24811] "Delayed"                                                                                                                                                              
[24812] "Dermal"                                                                                                                                                               
[24813] "Designated"                                                                                                                                                           
[24814] "Details"                                                                                                                                                              
[24815] "Detected"                                                                                                                                                             
[24816] "Diagnostic"                                                                                                                                                           
[24817] "Dimension"                                                                                                                                                            
[24818] "Discontinued"                                                                                                                                                         
[24819] "Display"                                                                                                                                                              
[24820] "Disruption"                                                                                                                                                           
[24821] "Dominant"                                                                                                                                                             
[24822] "Dose"                                                                                                                                                                 
[24823] "Dryness"                                                                                                                                                              
[24824] "During"                                                                                                                                                               
[24825] "Eastern_Cooperative_Oncology_Group"                                                                                                                                   
[24826] "Effect"                                                                                                                                                               
[24827] "Elevated"                                                                                                                                                             
[24828] "Elevation"                                                                                                                                                            
[24829] "Emotional"                                                                                                                                                            
[24830] "End"                                                                                                                                                                  
[24831] "Entire"                                                                                                                                                               
[24832] "Estimated"                                                                                                                                                            
[24833] "Event"                                                                                                                                                                
[24834] "Examined"                                                                                                                                                             
[24835] "Expected"                                                                                                                                                             
[24836] "Extracapsular"                                                                                                                                                        
[24837] "Extramedullary"                                                                                                                                                       
[24838] "Extranodal"                                                                                                                                                           
[24839] "Extraprostatic"                                                                                                                                                       
[24840] "Factor"                                                                                                                                                               
[24841] "Field"                                                                                                                                                                
[24842] "Final"                                                                                                                                                                
[24843] "First"                                                                                                                                                                
[24844] "Fissural"                                                                                                                                                             
[24845] "Focus"                                                                                                                                                                
[24846] "Foreign"                                                                                                                                                              
[24847] "Formation"                                                                                                                                                            
[24848] "Fraction"                                                                                                                                                             
[24849] "Frequency"                                                                                                                                                            
[24850] "From"                                                                                                                                                                 
[24851] "Full"                                                                                                                                                                 
[24852] "Function"                                                                                                                                                             
[24853] "Further"                                                                                                                                                              
[24854] "Gingival"                                                                                                                                                             
[24855] "Gynecologic_Oncology_Group"                                                                                                                                           
[24856] "Granulopenic"                                                                                                                                                         
[24857] "Grouping"                                                                                                                                                             
[24858] "HercepTest"                                                                                                                                                           
[24859] "Highest"                                                                                                                                                              
[24860] "Histologic"                                                                                                                                                           
[24861] "Histologically"                                                                                                                                                       
[24862] "Hormonal"                                                                                                                                                             
[24863] "Hour"                                                                                                                                                                 
[24864] "International_Breast_Cancer_Study_Group"                                                                                                                              
[24865] "Immature"                                                                                                                                                             
[24866] "Inclusion"                                                                                                                                                            
[24867] "Increase"                                                                                                                                                             
[24868] "Induration"                                                                                                                                                           
[24869] "Inflammatory"                                                                                                                                                         
[24870] "Initial"                                                                                                                                                              
[24871] "Initials"                                                                                                                                                             
[24872] "Intake"                                                                                                                                                               
[24873] "Intensity"                                                                                                                                                            
[24874] "Interlobar"                                                                                                                                                           
[24875] "International"                                                                                                                                                        
[24876] "Interruption"                                                                                                                                                         
[24877] "Interval"                                                                                                                                                             
[24878] "Into"                                                                                                                                                                 
[24879] "Intraclavicular"                                                                                                                                                      
[24880] "Invaded"                                                                                                                                                              
[24881] "Involved"                                                                                                                                                             
[24882] "Involvement"                                                                                                                                                          
[24883] "Isolated"                                                                                                                                                             
[24884] "Largest"                                                                                                                                                              
[24885] "Last"                                                                                                                                                                 
[24886] "Lead"                                                                                                                                                                 
[24887] "Leukemic_Cell"                                                                                                                                                        
[24888] "Level"                                                                                                                                                                
[24889] "Lower_Limit_of_Normal"                                                                                                                                                
[24890] "Lobar"                                                                                                                                                                
[24891] "Lobular"                                                                                                                                                              
[24892] "Longest"                                                                                                                                                              
[24893] "Loss"                                                                                                                                                                 
[24894] "Lost"                                                                                                                                                                 
[24895] "Lymphovascular"                                                                                                                                                       
[24896] "Main"                                                                                                                                                                 
[24897] "Margin"                                                                                                                                                               
[24898] "Maximum"                                                                                                                                                              
[24899] "Mesorectal"                                                                                                                                                           
[24900] "Metaplastic"                                                                                                                                                          
[24901] "Metastatic_Recurrent"                                                                                                                                                 
[24902] "Microinvasive"                                                                                                                                                        
[24903] "Middle"                                                                                                                                                               
[24904] "Minimum"                                                                                                                                                              
[24905] "Mode"                                                                                                                                                                 
[24906] "Modification"                                                                                                                                                         
[24907] "Modified"                                                                                                                                                             
[24908] "Molecular"                                                                                                                                                            
[24909] "Mononuclear"                                                                                                                                                          
[24910] "Monophasic"                                                                                                                                                           
[24911] "Most_Recent"                                                                                                                                                          
[24912] "Myocardial"                                                                                                                                                           
[24913] "Myometrial"                                                                                                                                                           
[24914] "N_Stage"                                                                                                                                                              
[24915] "North_Central_Cancer_Treatment_Group"                                                                                                                                 
[24916] "National_Cancer_Institute_of_Canada"                                                                                                                                  
[24917] "Nearest"                                                                                                                                                              
[24918] "Nervous"                                                                                                                                                              
[24919] "Nevus_Cell"                                                                                                                                                           
[24920] "New"                                                                                                                                                                  
[24921] "Newly_Diagnosed"                                                                                                                                                      
[24922] "Non-Malignant"                                                                                                                                                        
[24923] "Non-Measurable"                                                                                                                                                       
[24924] "Non-Protocol"                                                                                                                                                         
[24925] "Non-Surgical"                                                                                                                                                         
[24926] "Non-Target"                                                                                                                                                           
[24927] "Non-Visceral"                                                                                                                                                         
[24928] "Not"                                                                                                                                                                  
[24929] "Nottingham_Score"                                                                                                                                                     
[24930] "Breast_Feeding"                                                                                                                                                       
[24931] "Nutritional"                                                                                                                                                          
[24932] "Observation"                                                                                                                                                          
[24933] "Observed"                                                                                                                                                             
[24934] "Occupational"                                                                                                                                                         
[24935] "Off-Treatment"                                                                                                                                                        
[24936] "Opposite"                                                                                                                                                             
[24937] "Optional"                                                                                                                                                             
[24938] "Original"                                                                                                                                                             
[24939] "Overall"                                                                                                                                                              
[24940] "Palpable"                                                                                                                                                             
[24941] "Parametrial"                                                                                                                                                          
[24942] "Participating"                                                                                                                                                        
[24943] "Past"                                                                                                                                                                 
[24944] "Pathologic"                                                                                                                                                           
[24945] "Pectoral"                                                                                                                                                             
[24946] "Penetration"                                                                                                                                                          
[24947] "Percentage"                                                                                                                                                           
[24948] "Pericolic"                                                                                                                                                            
[24949] "Perineural"                                                                                                                                                           
[24950] "Period"                                                                                                                                                               
[24951] "Periprostatic"                                                                                                                                                        
[24952] "Physical"                                                                                                                                                             
[24953] "Planned"                                                                                                                                                              
[24954] "Platinum-Based"                                                                                                                                                       
[24955] "Postal_Code"                                                                                                                                                          
[24956] "Posterior"                                                                                                                                                            
[24957] "Post-Operative"                                                                                                                                                       
[24958] "Premalignant"                                                                                                                                                         
[24959] "Preparation"                                                                                                                                                          
[24960] "Present"                                                                                                                                                              
[24961] "Previous"                                                                                                                                                             
[24962] "Principal"                                                                                                                                                            
[24963] "Prior"                                                                                                                                                                
[24964] "Progress"                                                                                                                                                             
[24965] "Projected"                                                                                                                                                            
[24966] "Province"                                                                                                                                                             
[24967] "Proximity"                                                                                                                                                            
[24968] "Purpose"                                                                                                                                                              
[24969] "Qualifying"                                                                                                                                                           
[24970] "Rate"                                                                                                                                                                 
[24971] "Reaction"                                                                                                                                                             
[24972] "Reason"                                                                                                                                                               
[24973] "Received"                                                                                                                                                             
[24974] "Reduced"                                                                                                                                                              
[24975] "Reference"                                                                                                                                                            
[24976] "Referring"                                                                                                                                                            
[24977] "Regional"                                                                                                                                                             
[24978] "Registered"                                                                                                                                                           
[24979] "Registering"                                                                                                                                                          
[24980] "Registration"                                                                                                                                                         
[24981] "Regular"                                                                                                                                                              
[24982] "Related"                                                                                                                                                              
[24983] "Remaining"                                                                                                                                                            
[24984] "Removed"                                                                                                                                                              
[24985] "Reporting"                                                                                                                                                            
[24986] "Required"                                                                                                                                                             
[24987] "Resectable"                                                                                                                                                           
[24988] "Resected"                                                                                                                                                             
[24989] "Resolution"                                                                                                                                                           
[24990] "Respiratory"                                                                                                                                                          
[24991] "Responsible_Person"                                                                                                                                                   
[24992] "Restart"                                                                                                                                                              
[24993] "Retrieval"                                                                                                                                                            
[24994] "Retrotracheal"                                                                                                                                                        
[24995] "Reviewing"                                                                                                                                                            
[24996] "Sampling"                                                                                                                                                             
[24997] "Satellite"                                                                                                                                                            
[24998] "Scale"                                                                                                                                                                
[24999] "Scheme"                                                                                                                                                               
[25000] "Second"                                                                                                                                                               
[25001] "Secondary"                                                                                                                                                            
[25002] "Section"                                                                                                                                                              
[25003] "Security"                                                                                                                                                             
[25004] "Self-Administered"                                                                                                                                                    
[25005] "Seminal"                                                                                                                                                              
[25006] "Sent"                                                                                                                                                                 
[25007] "Sequence"                                                                                                                                                             
[25008] "Series"                                                                                                                                                               
[25009] "Serum_Immunologic"                                                                                                                                                    
[25010] "Severity"                                                                                                                                                             
[25011] "Shape"                                                                                                                                                                
[25012] "Signature"                                                                                                                                                            
[25013] "Signed"                                                                                                                                                               
[25014] "Sister"                                                                                                                                                               
[25015] "Size"                                                                                                                                                                 
[25016] "Slice"                                                                                                                                                                
[25017] "Source"                                                                                                                                                               
[25018] "Special"                                                                                                                                                              
[25019] "Specify"                                                                                                                                                              
[25020] "Social_Security_Number"                                                                                                                                               
[25021] "State"                                                                                                                                                                
[25022] "Status"                                                                                                                                                               
[25023] "Stratification"                                                                                                                                                       
[25024] "Street_Address"                                                                                                                                                       
[25025] "Subcarinal"                                                                                                                                                           
[25026] "Subcategory"                                                                                                                                                          
[25027] "Subgroup"                                                                                                                                                             
[25028] "Submission"                                                                                                                                                           
[25029] "Submitted"                                                                                                                                                            
[25030] "Subtype"                                                                                                                                                              
[25031] "Sum"                                                                                                                                                                  
[25032] "Surgical"                                                                                                                                                             
[25033] "Southwest_Oncology_Group"                                                                                                                                             
[25034] "System"                                                                                                                                                               
[25035] "Taken"                                                                                                                                                                
[25036] "Target"                                                                                                                                                               
[25037] "Term"                                                                                                                                                                 
[25038] "Text"                                                                                                                                                                 
[25039] "Treating"                                                                                                                                                             
[25040] "Upper_Limit_of_Normal"                                                                                                                                                
[25041] "Uncoated"                                                                                                                                                             
[25042] "Unfiltered"                                                                                                                                                           
[25043] "Unit_of_Measure"                                                                                                                                                      
[25044] "Update"                                                                                                                                                               
[25045] "Urinary"                                                                                                                                                              
[25046] "Value"                                                                                                                                                                
[25047] "Variation"                                                                                                                                                            
[25048] "Version"                                                                                                                                                              
[25049] "Vertebral"                                                                                                                                                            
[25050] "Visit"                                                                                                                                                                
[25051] "Vital_Status"                                                                                                                                                         
[25052] "Without"                                                                                                                                                              
[25053] "Worst"                                                                                                                                                                
[25054] "Zip_Code"                                                                                                                                                             
[25055] "Mesenchymal"                                                                                                                                                          
[25056] "Adjuvant_CADSR"                                                                                                                                                       
[25057] "Dermoid"                                                                                                                                                              
[25058] "Hilar"                                                                                                                                                                
[25059] "Intent"                                                                                                                                                               
[25060] "Pancreatic"                                                                                                                                                           
[25061] "M_Stage"                                                                                                                                                              
[25062] "T_Stage"                                                                                                                                                              
[25063] "Adherence"                                                                                                                                                            
[25064] "Concomitant"                                                                                                                                                          
[25065] "Cribriform"                                                                                                                                                           
[25066] "Ductal"                                                                                                                                                               
[25067] "En_Bloc"                                                                                                                                                              
[25068] "Breslow_Thickness"                                                                                                                                                    
[25069] "Inhaling"                                                                                                                                                             
[25070] "Fibrinogen"                                                                                                                                                           
[25071] "Identified"                                                                                                                                                           
[25072] "Infarction"                                                                                                                                                           
[25073] "Metabolism"                                                                                                                                                           
[25074] "Erection"                                                                                                                                                             
[25075] "Physician"                                                                                                                                                            
[25076] "Pregnancy"                                                                                                                                                            
[25077] "Urination"                                                                                                                                                            
[25078] "Failure"                                                                                                                                                              
[25079] "Recovery"                                                                                                                                                             
[25080] "Creatinine_Clearance"                                                                                                                                                 
[25081] "Iron_Binding_Capacity"                                                                                                                                                
[25082] "Pulse"                                                                                                                                                                
[25083] "Deterioration"                                                                                                                                                        
[25084] "Bronchoscopist"                                                                                                                                                       
[25085] "Infiltration"                                                                                                                                                         
[25086] "Response"                                                                                                                                                             
[25087] "Translocation"                                                                                                                                                        
[25088] "Ulceration"                                                                                                                                                           
[25089] "HPV-16_E7_Peptide"                                                                                                                                                    
[25090] "Clinical_Study_Element"                                                                                                                                               
[25091] "DNA_Crosslinking_Agent"                                                                                                                                               
[25092] "Surgically_Created_Structure"                                                                                                                                         
[25093] "Cardiovascular_System_Part"                                                                                                                                           
[25094] "Gastrointestinal_System_Part"                                                                                                                                         
[25095] "Secondary_Acute_Myeloid_Leukemia"                                                                                                                                     
[25096] "Cervical_Neck_Region"                                                                                                                                                 
[25097] "Digestive_System_Part"                                                                                                                                                
[25098] "Musculoskeletal_System_Part"                                                                                                                                          
[25099] "Mucous_Membrane"                                                                                                                                                      
[25100] "Metastatic_Malignant_Testicular_Germ_Cell_Tumor"                                                                                                                      
[25101] "Cerebral_Cavernous_Malformations-1_Protein"                                                                                                                           
[25102] "Cyclin-B2"                                                                                                                                                            
[25103] "Phalanx_of_the_Foot"                                                                                                                                                  
[25104] "Chemokine_Receptor_Gene"                                                                                                                                              
[25105] "C-C_Motif_Chemokine_Receptor-1"                                                                                                                                       
[25106] "C-C_Motif_Chemokine_Receptor-5"                                                                                                                                       
[25107] "C-C_Motif_Chemokine_Receptor-6"                                                                                                                                       
[25108] "C-C_Motif_Chemokine_Receptor-8"                                                                                                                                       
[25109] "C-C_Motif_Chemokine_Receptor-9"                                                                                                                                       
[25110] "RAS_Family_Gene"                                                                                                                                                      
[25111] "KRAS2_Gene"                                                                                                                                                           
[25112] "NRAS_Gene"                                                                                                                                                            
[25113] "Ductal_Epithelium"                                                                                                                                                    
[25114] "C-C_Motif_Chemokine_Receptor-Like_1_Protein"                                                                                                                          
[25115] "C-C_Motif_Chemokine_Receptor-Like_2_Protein"                                                                                                                          
[25116] "Immunoprotein_Gene"                                                                                                                                                   
[25117] "Immunoglobulin_Family_Gene"                                                                                                                                           
[25118] "T-Cell_Surface_Glycoprotein-CD3_Epsilon_Chain"                                                                                                                        
[25119] "Immunoglobulin-Like_C2-Type_Domain"                                                                                                                                   
[25120] "Immunoglobulin-Like_V-Type_Domain"                                                                                                                                    
[25121] "CD47_Antigen"                                                                                                                                                         
[25122] "Eukaryote"                                                                                                                                                            
[25123] "E7070"                                                                                                                                                                
[25124] "CD97_Antigen"                                                                                                                                                         
[25125] "ADAM11_Protein"                                                                                                                                                       
[25126] "Cystatin-6"                                                                                                                                                           
[25127] "Cell_Division_Cycle-2-Like-1_Protein"                                                                                                                                 
[25128] "Chaperone_Gene"                                                                                                                                                       
[25129] "CDC37_Homolog_Protein"                                                                                                                                                
[25130] "Hydrolase_Gene"                                                                                                                                                       
[25131] "GTPase_Gene"                                                                                                                                                          
[25132] "Mouse_Urinary_Tract_Neoplasm"                                                                                                                                         
[25133] "Mouse_Bladder_Neoplasm"                                                                                                                                               
[25134] "Mouse_Bladder_Paraganglioma"                                                                                                                                          
[25135] "Mouse_Bladder_Inflammatory_Myofibroblastic_Neoplasm"                                                                                                                  
[25136] "Benign_Mouse_Bladder_Neoplasm"                                                                                                                                        
[25137] "Benign_Mouse_Bladder_Paraganglioma"                                                                                                                                   
[25138] "Mouse_Bladder_Leiomyoma"                                                                                                                                              
[25139] "Mouse_Bladder_Papilloma"                                                                                                                                              
[25140] "Malignant_Mouse_Bladder_Neoplasm"                                                                                                                                     
[25141] "Malignant_Mouse_Bladder_Paraganglioma"                                                                                                                                
[25142] "Metastatic_Neoplasm_to_the_Mouse_Urinary_Bladder"                                                                                                                     
[25143] "Cell_Division_Cycle-42_Protein"                                                                                                                                       
[25144] "Mouse_Bladder_Lymphoma"                                                                                                                                               
[25145] "Mouse_Bladder_Sarcoma"                                                                                                                                                
[25146] "Mouse_Bladder_Carcinoma"                                                                                                                                              
[25147] "Mouse_Bladder_Adenocarcinoma"                                                                                                                                         
[25148] "Mouse_Bladder_Squamous_Cell_Carcinoma"                                                                                                                                
[25149] "Mouse_Bladder_Transitional_Cell_Carcinoma"                                                                                                                            
[25150] "Chloride"                                                                                                                                                             
[25151] "DNA_Adduction"                                                                                                                                                        
[25152] "DNA_Alkylation"                                                                                                                                                       
[25153] "DNA_Crosslinking"                                                                                                                                                     
[25154] "DNA_Interstrand_Crosslinking"                                                                                                                                         
[25155] "DNA_Intrastrand_Crosslinking"                                                                                                                                         
[25156] "DNA_Strand_Break"                                                                                                                                                     
[25157] "DNA_Single_Strand_Break"                                                                                                                                              
[25158] "DNA_Double_Strand_Break"                                                                                                                                              
[25159] "Abasic_Site_Formation"                                                                                                                                                
[25160] "Formation_of_Apurinic_Site"                                                                                                                                           
[25161] "Formation_of_Apyrimidine_Site"                                                                                                                                        
[25162] "Formation_of_Bistrand_Abasic_Site"                                                                                                                                    
[25163] "Base-Base_Mismatch"                                                                                                                                                   
[25164] "Annamycin_Liposomal"                                                                                                                                                  
[25165] "Cyclin-Dependent_Kinase_Gene"                                                                                                                                         
[25166] "Cyclin_Gene"                                                                                                                                                          
[25167] "Cyclin-Dependent_Kinase-10"                                                                                                                                           
[25168] "Cyclin-Dependent_Kinase-2"                                                                                                                                            
[25169] "BARD-1_Protein"                                                                                                                                                       
[25170] "CREB-Related_Protein-2"                                                                                                                                               
[25171] "Deleted_in_Split_Hand-Split_Foot_Protein-1"                                                                                                                           
[25172] "CDK_Inhibitor_Gene"                                                                                                                                                   
[25173] "Epithelial_Discoidin_Domain_Receptor-1"                                                                                                                               
[25174] "Dual_Specificity_Phosphatase-3"                                                                                                                                       
[25175] "CDK_Inhibitor_Protein"                                                                                                                                                
[25176] "CDK2-Associated_Protein-1"                                                                                                                                            
[25177] "Fibroblast_Growth_Factor_Receptor-4"                                                                                                                                  
[25178] "Growth_Arrest_Specific_11_Protein"                                                                                                                                    
[25179] "Organic_Cation_Transporter-Like_2_Protein"                                                                                                                            
[25180] "ADAM_Type_Metalloprotease_Domain"                                                                                                                                     
[25181] "Integrin_Binding"                                                                                                                                                     
[25182] "Cyclin-Dependent_Kinase-3"                                                                                                                                            
[25183] "cDNA_Microarray"                                                                                                                                                      
[25184] "Protein_Microarray"                                                                                                                                                   
[25185] "G1-S_Transition"                                                                                                                                                      
[25186] "Transmembrane_Protein_Gene"                                                                                                                                           
[25187] "Transferase_Gene"                                                                                                                                                     
[25188] "Phosphotransferase_Gene"                                                                                                                                              
[25189] "Kinase_Family_Gene"                                                                                                                                                   
[25190] "Serine-Threonine_Protein_Kinase_Gene"                                                                                                                                 
[25191] "Cyclin-Dependent_Kinase-Like-2_Protein"                                                                                                                               
[25192] "Cyclin-Dependent_Kinase_Inhibitor-2C"                                                                                                                                 
[25193] "Cyclin-Dependent_Kinase_Inhibitor-3"                                                                                                                                  
[25194] "Dual-Specificity_Phosphoprotein_Phosphatase"                                                                                                                          
[25195] "Surface_Glycoprotein_Ig_Superfamily_Member"                                                                                                                           
[25196] "Cerebellar-Degeneration-Related_Antigen-1"                                                                                                                            
[25197] "Homeobox_Protein"                                                                                                                                                     
[25198] "Caudal_Type_Homeobox_Transcription_Factor-2"                                                                                                                          
[25199] "CEA_Family_Gene"                                                                                                                                                      
[25200] "CEA_Family_Protein"                                                                                                                                                   
[25201] "N_Domain"                                                                                                                                                             
[25202] "CEACAM7_Protein"                                                                                                                                                      
[25203] "Protocadherin_Flamingo-2_Protein"                                                                                                                                     
[25204] "Serotonin-5-HT-3_Receptor"                                                                                                                                            
[25205] "HTR3_Gene"                                                                                                                                                            
[25206] "_11q23_1-q23_2"                                                                                                                                                       
[25207] "CHK1_Checkpoint_Homolog_Protein"                                                                                                                                      
[25208] "Choline_Kinase"                                                                                                                                                       
[25209] "Muscarinic_Acetylcholine_Receptor-M4"                                                                                                                                 
[25210] "DNA_Microarray"                                                                                                                                                       
[25211] "_15q15_3"                                                                                                                                                             
[25212] "Investigator"                                                                                                                                                         
[25213] "Mitochondrial_Membrane"                                                                                                                                               
[25214] "Nuclear_Inner_Membrane"                                                                                                                                               
[25215] "Oxidoreductase_Gene"                                                                                                                                                  
[25216] "Nuclear_Outer_Membrane"                                                                                                                                               
[25217] "Isomerase_Gene"                                                                                                                                                       
[25218] "Polymerase_Gene"                                                                                                                                                      
[25219] "Ligase_Gene"                                                                                                                                                          
[25220] "Cytochrome-P450-2C19"                                                                                                                                                 
[25221] "Hydrochloride_Salt"                                                                                                                                                   
[25222] "Maleate"                                                                                                                                                              
[25223] "Esterase_Gene"                                                                                                                                                        
[25224] "Ribonuclease_Gene"                                                                                                                                                    
[25225] "Endoribonuclease_Gene"                                                                                                                                                
[25226] "Rnase-III_Gene"                                                                                                                                                       
[25227] "DICER1_Gene"                                                                                                                                                          
[25228] "_14q32_2"                                                                                                                                                             
[25229] "Double-Stranded_RNA_Binding_Domain"                                                                                                                                   
[25230] "Endoribonuclease"                                                                                                                                                     
[25231] "Rnase-III_Family_Protein"                                                                                                                                             
[25232] "Endoribonuclease_Dicer"                                                                                                                                               
[25233] "PHAPI2_Protein"                                                                                                                                                       
[25234] "Yp11_2"                                                                                                                                                               
[25235] "Small_RNA"                                                                                                                                                            
[25236] "Toll-Like_Receptor_Family_Gene"                                                                                                                                       
[25237] "MicroRNA"                                                                                                                                                             
[25238] "pri-miRNA"                                                                                                                                                            
[25239] "pre-miRNA"                                                                                                                                                            
[25240] "Cytoplasmic_Protein_Gene"                                                                                                                                             
[25241] "Lysosomal_Trafficking_Regulator"                                                                                                                                      
[25242] "Non-Receptor_Tyrosine_Kinase_Gene"                                                                                                                                    
[25243] "Non-Receptor_Protein_Tyrosine_Phosphatase_Gene"                                                                                                                       
[25244] "Tubulin_Binding_Agent"                                                                                                                                                
[25245] "Mitochondrial_RNA"                                                                                                                                                    
[25246] "Cytokine_Signaling"                                                                                                                                                   
[25247] "Suppressor_of_Cytokine_Signaling_Family_Gene"                                                                                                                         
[25248] "Suppressor_of_Cytokine_Signaling_Family_Protein"                                                                                                                      
[25249] "Cytokine_Inducible_SH2-Containing_Protein"                                                                                                                            
[25250] "SOCS_Box_Domain"                                                                                                                                                      
[25251] "Membrane-Associated_Guanylate_Kinase_Family_Gene"                                                                                                                     
[25252] "Interleukin_Gene"                                                                                                                                                     
[25253] "Nerve_Cell_Survival"                                                                                                                                                  
[25254] "Cardiotrophin-Like_Cytokine"                                                                                                                                          
[25255] "Chemokine-Like_Receptor-1"                                                                                                                                            
[25256] "Polo-Box_Domain"                                                                                                                                                      
[25257] "_17q21_2"                                                                                                                                                             
[25258] "Cytokine-Inducible_Kinase"                                                                                                                                            
[25259] "Homeostasis"                                                                                                                                                          
[25260] "Connector_Enhancer_of_KSR-Like_Protein"                                                                                                                               
[25261] "Signal_Transducer_and_Activator_of_Transcription_Family_Gene"                                                                                                         
[25262] "Ion_Channel_Protein_Gene"                                                                                                                                             
[25263] "Peptide_Hormone_Gene"                                                                                                                                                 
[25264] "RNA_Polymerase_Inhibitor"                                                                                                                                             
[25265] "Gene_with_Unknown_or_Unclassified_Function"                                                                                                                           
[25266] "Adaptor_Signaling_Protein_Gene"                                                                                                                                       
[25267] "_2p25_3"                                                                                                                                                              
[25268] "Contactin_Associated_Protein-1"                                                                                                                                       
[25269] "Extracellular_Matrix_Protein_Gene"                                                                                                                                    
[25270] "Collagen_Gene"                                                                                                                                                        
[25271] "Collagen_IV_Alpha-3"                                                                                                                                                  
[25272] "Protease_Gene"                                                                                                                                                        
[25273] "Gene_Family"                                                                                                                                                          
[25274] "_16p12_1"                                                                                                                                                             
[25275] "Trafficking_Protein_Gene"                                                                                                                                             
[25276] "Collagen_IV_Alpha-6"                                                                                                                                                  
[25277] "_17q11-q21"                                                                                                                                                           
[25278] "CC_Cytokine_Gene"                                                                                                                                                     
[25279] "CXC_Cytokine_Gene"                                                                                                                                                    
[25280] "Antiviral_Response"                                                                                                                                                   
[25281] "Antibacterial_Response"                                                                                                                                               
[25282] "_16q13"                                                                                                                                                               
[25283] "Protein_Complex_Subunit_Gene"                                                                                                                                         
[25284] "Vitamin_Other"                                                                                                                                                        
[25285] "Biological_Carcinogenesis_Non-Viral"                                                                                                                                  
[25286] "Viral_Carcinogenesis"                                                                                                                                                 
[25287] "Terrorism_Research"                                                                                                                                                   
[25288] "Bioterrorism_Research"                                                                                                                                                
[25289] "Genetic_Testing_Research_Human"                                                                                                                                       
[25290] "Iatrogenesis"                                                                                                                                                         
[25291] "No_SIC"                                                                                                                                                               
[25292] "Pediatric_Research"                                                                                                                                                   
[25293] "Cytochrome_C_Oxidase_Subunit-Vic"                                                                                                                                     
[25294] "Vaccine_Research"                                                                                                                                                     
[25295] "Vaccine_Production"                                                                                                                                                   
[25296] "Vaccine_Testing"                                                                                                                                                      
[25297] "Casein_Kinase_1_Alpha-1"                                                                                                                                              
[25298] "Cytochrome_C_Oxidase"                                                                                                                                                 
[25299] "_2q33-q37"                                                                                                                                                            
[25300] "_4q21_2"                                                                                                                                                              
[25301] "Food_Safety"                                                                                                                                                          
[25302] "Unborn_Children_Conditions_Affecting"                                                                                                                                 
[25303] "Membrane_Protein_Gene"                                                                                                                                                
[25304] "Tumor_Suppression"                                                                                                                                                    
[25305] "Copine-VII"                                                                                                                                                           
[25306] "C2_Domain"                                                                                                                                                            
[25307] "Von_Willebrand_Factor_A_Domain"                                                                                                                                       
[25308] "Angiogenic_Inhibition"                                                                                                                                                
[25309] "Yp"                                                                                                                                                                   
[25310] "Hematopoietic_Factor_Gene"                                                                                                                                            
[25311] "Colony-Stimulating_Factor_Gene"                                                                                                                                       
[25312] "RGS_Family_Gene"                                                                                                                                                      
[25313] "Nucleosome_Assembly_Protein_Gene"                                                                                                                                     
[25314] "Sushi_Domain"                                                                                                                                                         
[25315] "Retinoic_Acid_Binding"                                                                                                                                                
[25316] "Autoimmune_Status"                                                                                                                                                    
[25317] "_22q13"                                                                                                                                                               
[25318] "Extracellular_Space"                                                                                                                                                  
[25319] "_9p21_3"                                                                                                                                                              
[25320] "Helicase_Gene"                                                                                                                                                        
[25321] "Protein_Tyrosine_Phosphatase_Gene"                                                                                                                                    
[25322] "Alpha-Globulin"                                                                                                                                                       
[25323] "_12q14_3"                                                                                                                                                             
[25324] "Secretory_Granule"                                                                                                                                                    
[25325] "Secretory_Vesicle"                                                                                                                                                    
[25326] "Protein_Serine-Threonine_Phosphatase_Gene"                                                                                                                            
[25327] "Ubiquitin_Protein_Ligase"                                                                                                                                             
[25328] "Ubiquitin_Ligase_Gene"                                                                                                                                                
[25329] "_16p12_3"                                                                                                                                                             
[25330] "Bone_Morphogenetic_Protein_Gene"                                                                                                                                      
[25331] "_2p13_2"                                                                                                                                                              
[25332] "Phosphatase_Family_Gene"                                                                                                                                              
[25333] "_3q22_3"                                                                                                                                                              
[25334] "Phosphoinositol_Kinase_Family_Gene"                                                                                                                                   
[25335] "_7q22_2"                                                                                                                                                              
[25336] "Cullin_Family_Gene"                                                                                                                                                   
[25337] "_10p11_21"                                                                                                                                                            
[25338] "Arrestin_Beta-1"                                                                                                                                                      
[25339] "_10q26_2"                                                                                                                                                             
[25340] "Colony_Stimulating_Factor-3"                                                                                                                                          
[25341] "Colony_Stimulating_Factor-3_Receptor"                                                                                                                                 
[25342] "Granulopoiesis"                                                                                                                                                       
[25343] "ATP8A2_Protein"                                                                                                                                                       
[25344] "Casein_Kinase-2_Alpha-1_Polypeptide"                                                                                                                                  
[25345] "Chondroitin_Sulfate_Proteoglycan-4"                                                                                                                                   
[25346] "Chondroitin_Sulfate_Proteoglycan-6"                                                                                                                                   
[25347] "C-Terminal_Binding_Protein-2"                                                                                                                                         
[25348] "Cardiotrophin-1"                                                                                                                                                      
[25349] "Cathepsin-Z"                                                                                                                                                          
[25350] "Cullin-1_Protein"                                                                                                                                                     
[25351] "Arginine_Vasopressin-Neurophysin-II_Preproprotein"                                                                                                                    
[25352] "Cullin-2_Protein"                                                                                                                                                     
[25353] "Cullin_Family_Protein"                                                                                                                                                
[25354] "Cullin-3_Protein"                                                                                                                                                     
[25355] "Cullin-4A_Protein"                                                                                                                                                    
[25356] "Cullin-5_Protein"                                                                                                                                                     
[25357] "Arginine_Vasopressin_Receptor-1A"                                                                                                                                     
[25358] "Arginine_Vasopressin_Receptor-1B"                                                                                                                                     
[25359] "Arginine_Vasopressin_Receptor-2"                                                                                                                                      
[25360] "Bradykinin_Receptor-B2"                                                                                                                                               
[25361] "Burkitt_Lymphoma_Receptor-1_Protein"                                                                                                                                  
[25362] "C_Motif_Chemokine_Receptor-1"                                                                                                                                         
[25363] "Colony_Stimulating_Factor-2_Receptor_Beta"                                                                                                                            
[25364] "Coagulation_Factor-II_Receptor"                                                                                                                                       
[25365] "Fas-Associated_Via_Death_Domain_Protein"                                                                                                                              
[25366] "Deleted_in_Malignant_Brain_Tumors-1_Protein"                                                                                                                          
[25367] "Scavenger_Receptor_Cysteine-Rich_Domain"                                                                                                                              
[25368] "SRCR-Interspersed_Domain"                                                                                                                                             
[25369] "Methyltransferase_Gene"                                                                                                                                               
[25370] "ADD-Type_Zinc-Finger"                                                                                                                                                 
[25371] "DNA_Methyltransferase-3B"                                                                                                                                             
[25372] "DOC-1_Related_Protein"                                                                                                                                                
[25373] "Cell_Surface_Extension"                                                                                                                                               
[25374] "Phagocytosis"                                                                                                                                                         
[25375] "Dedicator_of_Cyto-Kinesis-1_Protein"                                                                                                                                  
[25376] "Docking_Protein-1"                                                                                                                                                    
[25377] "PTB_Domain"                                                                                                                                                           
[25378] "DOK_Domain"                                                                                                                                                           
[25379] "Dopamine_Receptor-D1"                                                                                                                                                 
[25380] "Dopamine_Receptor-D4"                                                                                                                                                 
[25381] "Dopamine_Receptor-D5"                                                                                                                                                 
[25382] "Diphtheria_Toxin_Receptor"                                                                                                                                            
[25383] "Heparin_Binding"                                                                                                                                                      
[25384] "Fibroblast_Growth_Factor-10"                                                                                                                                          
[25385] "Fibroblast_Growth_Factor-20"                                                                                                                                          
[25386] "Fibroblast_Growth_Factor-21"                                                                                                                                          
[25387] "Fibroblast_Growth_Factor-8"                                                                                                                                           
[25388] "Fibroblast_Growth_Factor_Receptor-3"                                                                                                                                  
[25389] "Endometrial_Bleeding_Associated_Factor"                                                                                                                               
[25390] "Growth_Factor_Receptor_Gene"                                                                                                                                          
[25391] "Fibroblast_Growth_Factor_Receptor-Like-1_Protein"                                                                                                                     
[25392] "Fas-Activated_Serine-Threonine_Kinase"                                                                                                                                
[25393] "Glomulin"                                                                                                                                                             
[25394] "DNA_Repair_Protein-XRCC9"                                                                                                                                             
[25395] "Exostosin-Like-1_Protein"                                                                                                                                             
[25396] "Exostosin-Like-2_Protein"                                                                                                                                             
[25397] "Exostosin-Like-3_Protein"                                                                                                                                             
[25398] "STAT4_Gene"                                                                                                                                                           
[25399] "_2q32_2-q32_3"                                                                                                                                                        
[25400] "BCL2-Associated_Athanogene-4"                                                                                                                                         
[25401] "Cell_Fate_Control"                                                                                                                                                    
[25402] "Deltex_Homolog-1_Protein"                                                                                                                                             
[25403] "BCL2-Associated_Athanogene-5"                                                                                                                                         
[25404] "Brain-Specific_Angiogenesis_Inhibitor-1"                                                                                                                              
[25405] "Fibroblast_Growth_Factor-9"                                                                                                                                           
[25406] "Glycosyltransferase_Gene"                                                                                                                                             
[25407] "Platelet-Derived_Endothelial_Cell_Growth_Factor-1"                                                                                                                    
[25408] "B-Cell_Lymphoma-6_Protein"                                                                                                                                            
[25409] "Glial_Cell_Proliferation"                                                                                                                                             
[25410] "Endothelin-2"                                                                                                                                                         
[25411] "B-Cell_CLL_Lymphoma-10"                                                                                                                                               
[25412] "Epidermal_Growth_Factor-Like_Protein-6"                                                                                                                               
[25413] "ETS_Homologous_Factor"                                                                                                                                                
[25414] "Ephrin_Receptor-Epha2"                                                                                                                                                
[25415] "Elastin_Microfibril_Interfacer-1_Protein"                                                                                                                             
[25416] "_2q36_1"                                                                                                                                                              
[25417] "Ephrin_Receptor-EphA4"                                                                                                                                                
[25418] "Ephrin_Receptor-EphA8"                                                                                                                                                
[25419] "Nervous_System_Development"                                                                                                                                           
[25420] "Ephrin_Receptor-EphB1"                                                                                                                                                
[25421] "Frizzled-2_Protein"                                                                                                                                                   
[25422] "Frizzled_Domain"                                                                                                                                                      
[25423] "Frizzled-3_Protein"                                                                                                                                                   
[25424] "Ephrin_Receptor-EphB2"                                                                                                                                                
[25425] "Frizzled-4_Protein"                                                                                                                                                   
[25426] "Ephrin_Receptor-EphB3"                                                                                                                                                
[25427] "Cell_Migration"                                                                                                                                                       
[25428] "Protective_Agent"                                                                                                                                                     
[25429] "Epiregulin"                                                                                                                                                           
[25430] "Frizzled-7_Protein"                                                                                                                                                   
[25431] "Ets2_Repressor_Factor"                                                                                                                                                
[25432] "_5q12_2"                                                                                                                                                              
[25433] "ERBB2_Interacting_Protein"                                                                                                                                            
[25434] "Ets_Variant_Protein-1"                                                                                                                                                
[25435] "Ets_Variant_Protein-4"                                                                                                                                                
[25436] "EGF_Receptor_Pathway_Substrate-8"                                                                                                                                     
[25437] "EGF_Receptor_Pathway_Substrate-15"                                                                                                                                    
[25438] "Frizzled-6_Protein"                                                                                                                                                   
[25439] "Gastric_Inhibitory_Polypeptide_Receptor"                                                                                                                              
[25440] "G_Protein-Coupled_Receptor_Kinase-Interactor-1"                                                                                                                       
[25441] "G_Protein-Coupled_Receptor_Kinase-Interactor-2"                                                                                                                       
[25442] "Frizzled-9_Protein"                                                                                                                                                   
[25443] "Guanine_Nucleotide_Binding_Protein_Alpha-Z"                                                                                                                           
[25444] "Guanine_Nucleotide_Binding_Protein_Alpha-12"                                                                                                                          
[25445] "G-Protein_Alpha_Subunit-I2"                                                                                                                                           
[25446] "Heterotrimeric_G_Protein_Subunit_Gene"                                                                                                                                
[25447] "GRB2-Associated_Binding_Protein-2"                                                                                                                                    
[25448] "Guanine_Nucleotide_Binding_Protein_Beta-1"                                                                                                                            
[25449] "Guanine_Nucleotide_Binding_Protein_Beta-2"                                                                                                                            
[25450] "Guanine_Nucleotide_Binding_Protein_Beta-3"                                                                                                                            
[25451] "G_Protein-Coupled_Receptor-17"                                                                                                                                        
[25452] "Leucine-Rich_Repeat"                                                                                                                                                  
[25453] "Four_and_a_Half_LIM_Domains-2_Protein"                                                                                                                                
[25454] "Transcription_Regulatory_Protein"                                                                                                                                     
[25455] "Leucine_Rich_Repeat_Neuronal-5_Protein"                                                                                                                               
[25456] "Acidic_Fibroblast_Growth_Factor_Intracellular_Binding_Protein"                                                                                                        
[25457] "Fms-Related_Tyrosine_Kinase-3"                                                                                                                                        
[25458] "FMS-Related_Tyrosine_Kinase-4"                                                                                                                                        
[25459] "G_Protein-Coupled_Receptor-2"                                                                                                                                         
[25460] "G_Protein-Coupled_Receptor-32"                                                                                                                                        
[25461] "G_Protein-Coupled_Receptor-68"                                                                                                                                        
[25462] "Forkhead_Box-O1A_Protein"                                                                                                                                             
[25463] "Formyl_Peptide_Receptor-1"                                                                                                                                            
[25464] "Fractalkine_Receptor"                                                                                                                                                 
[25465] "Disabled_Homolog-2_Protein"                                                                                                                                           
[25466] "Discoidin_Domain_Receptor-2"                                                                                                                                          
[25467] "DEAD-H_Box_Protein-1"                                                                                                                                                 
[25468] "DEAD-H_Box_Protein-16"                                                                                                                                                
[25469] "DEC1_Protein"                                                                                                                                                         
[25470] "Beta_Defensin-1_Protein"                                                                                                                                              
[25471] "DEK_Protein"                                                                                                                                                          
[25472] "DLEC1_Protein"                                                                                                                                                        
[25473] "DLEU1_Protein"                                                                                                                                                        
[25474] "DLEU2_Protein"                                                                                                                                                        
[25475] "GRB2-Related_Adaptor_Protein"                                                                                                                                         
[25476] "Growth_Factor_Receptor-Bound_Protein-2"                                                                                                                               
[25477] "Growth_Factor_Receptor-Bound_Protein-7"                                                                                                                               
[25478] "Xq13"                                                                                                                                                                 
[25479] "C-X-C_Motif_Chemokine_Receptor-3"                                                                                                                                     
[25480] "Growth_Factor_Receptor-Bound_Protein-10"                                                                                                                              
[25481] "Orphan_G-Protein_Coupled_Receptor"                                                                                                                                    
[25482] "Growth_Factor_Receptor-Bound_Protein-14"                                                                                                                              
[25483] "Adaptor_Signaling_Protein"                                                                                                                                            
[25484] "G_Protein-Coupled_Receptor_Kinase-2-Like_Protein"                                                                                                                     
[25485] "G_Protein-Coupled_Receptor_Kinase_Family"                                                                                                                             
[25486] "G_Protein-Coupled_Receptor_Kinase_Gene"                                                                                                                               
[25487] "G_Protein-Coupled_Receptor_Kinase-5"                                                                                                                                  
[25488] "Guanine_Nucleotide-Releasing_Factor-2"                                                                                                                                
[25489] "G_Protein-Coupled_Receptor_Kinase-6"                                                                                                                                  
[25490] "Ionotrophic_Glutamate_Receptor_AMPA3"                                                                                                                                 
[25491] "Metabotropic_Glutamate_Receptor-1"                                                                                                                                    
[25492] "_11q14_1"                                                                                                                                                             
[25493] "Metabotropic_Glutamate_Receptor-5"                                                                                                                                    
[25494] "G_Protein-Coupled_Receptor_Kinase-7"                                                                                                                                  
[25495] "Metabotropic_Glutamate_Receptor-6"                                                                                                                                    
[25496] "Glutathione_S-Transferase_Theta-1"                                                                                                                                    
[25497] "Hepatocyte_Growth_Factor-Regulated_Tyrosine_Kinase_Substrate"                                                                                                         
[25498] "G_Protein_Pathway_Suppressor-1_Protein"                                                                                                                               
[25499] "Galanin_Receptor-2"                                                                                                                                                   
[25500] "G_Protein_Pathway_Suppressor-2_Protein"                                                                                                                               
[25501] "Regulator_of_G-Protein_Signaling-1_Protein"                                                                                                                           
[25502] "Regulator_of_G-Protein_Signaling-2_Protein"                                                                                                                           
[25503] "Regulator_of_G-Protein_Signaling-3_Protein"                                                                                                                           
[25504] "Regulator_of_G-Protein_Signaling-19_Protein"                                                                                                                          
[25505] "Insulin-Like_Growth_Factor-2_Receptor"                                                                                                                                
[25506] "Interleukin-6_Signal_Transducer"                                                                                                                                      
[25507] "Interleukin-2_Receptor_Gamma"                                                                                                                                         
[25508] "Interleukin-2_Receptor_Beta"                                                                                                                                          
[25509] "Interleukin-4_Receptor"                                                                                                                                               
[25510] "Interleukin-5_Receptor_Alpha"                                                                                                                                         
[25511] "Interleukin-10_Receptor_Beta"                                                                                                                                         
[25512] "Interleukin-11_Receptor_Alpha"                                                                                                                                        
[25513] "Africa"                                                                                                                                                               
[25514] "Asia"                                                                                                                                                                 
[25515] "Europe"                                                                                                                                                               
[25516] "North_America"                                                                                                                                                        
[25517] "Oceania"                                                                                                                                                              
[25518] "South_America"                                                                                                                                                        
[25519] "Interleukin-7_Receptor"                                                                                                                                               
[25520] "Immunoglobulin_Switch_Recombination"                                                                                                                                  
[25521] "Immune_Cell_Activation"                                                                                                                                               
[25522] "Neutrophil_Activation"                                                                                                                                                
[25523] "Interleukin-8_Receptor_Alpha"                                                                                                                                         
[25524] "GAS41_Protein"                                                                                                                                                        
[25525] "Interleukin-8_Receptor_Beta"                                                                                                                                          
[25526] "Integrin-Linked_Kinase"                                                                                                                                               
[25527] "Inhibitor_of_Growth-1_Protein"                                                                                                                                        
[25528] "_2p12-p13"                                                                                                                                                            
[25529] "Bone_Morphogenetic_Protein-3B"                                                                                                                                        
[25530] "_7p15-p14_2"                                                                                                                                                          
[25531] "_12q13_3"                                                                                                                                                             
[25532] "_11p15_1"                                                                                                                                                             
[25533] "_9p21-p22"                                                                                                                                                            
[25534] "_6p22_1"                                                                                                                                                              
[25535] "INHBB_Gene"                                                                                                                                                           
[25536] "Hepatocellular_Carcinoma_Protein-HHCM"                                                                                                                                
[25537] "IRAK2_Gene"                                                                                                                                                           
[25538] "IRAK4_Gene"                                                                                                                                                           
[25539] "Hexokinase-2"                                                                                                                                                         
[25540] "Chemokine_Receptor-HM74"                                                                                                                                              
[25541] "IRF3_Gene"                                                                                                                                                            
[25542] "Heterogeneous_Nuclear_Ribonucleoprotein-A3"                                                                                                                           
[25543] "Homeobox_Protein-A10"                                                                                                                                                 
[25544] "Homeobox_Protein-A9"                                                                                                                                                  
[25545] "Homeobox_Protein-C6"                                                                                                                                                  
[25546] "HPCA_Protein"                                                                                                                                                         
[25547] "Heparanase"                                                                                                                                                           
[25548] "Hydroxysteroid-17-Beta_Dehydrogenase-7"                                                                                                                               
[25549] "TAT-Interacting_Protein-TIP30"                                                                                                                                        
[25550] "Interferon-Induced_Transmembrane_Protein-1"                                                                                                                           
[25551] "Interferon_Alpha-13"                                                                                                                                                  
[25552] "Interferon_Alpha-2"                                                                                                                                                   
[25553] "Interferon_Omega-1"                                                                                                                                                   
[25554] "Caribbean"                                                                                                                                                            
[25555] "Leukemia_Inhibitory_Factor_Receptor"                                                                                                                                  
[25556] "Growth_Differentiation_Factor-5"                                                                                                                                      
[25557] "Hematologic_Disorder"                                                                                                                                                 
[25558] "Non-Neoplastic_Hematologic_Disorder"                                                                                                                                  
[25559] "Non-Neoplastic_Connective_and_Soft_Tissue_Disorder"                                                                                                                   
[25560] "Protein-Lysine-6-Oxidase"                                                                                                                                             
[25561] "Growth_Differentiation_Factor-8"                                                                                                                                      
[25562] "Leukotriene-B4_Receptor"                                                                                                                                              
[25563] "Ghana"                                                                                                                                                                
[25564] "Latent_TGF_Beta_Binding_Protein-2"                                                                                                                                    
[25565] "Leukocyte_Tyrosine_Kinase"                                                                                                                                            
[25566] "Lymphocyte_Antigen-LY6E"                                                                                                                                              
[25567] "IGF-II_mRNA-Binding_Protein-3"                                                                                                                                        
[25568] "Kinase_Suppressor_of_RAS-1"                                                                                                                                           
[25569] "Middle_East"                                                                                                                                                          
[25570] "PTPN11_Gene"                                                                                                                                                          
[25571] "Lymphoid_Nuclear_Protein-4"                                                                                                                                           
[25572] "Non-Receptor_Type_1_Protein_Tyrosine_Phosphatase"                                                                                                                     
[25573] "Lysosomal-Associated_Membrane_Protein-3"                                                                                                                              
[25574] "Non-Receptor_Type_12_Protein_Tyrosine_Phosphatase"                                                                                                                    
[25575] "Non-Receptor_Type_22_Protein_Tyrosine_Phosphatase"                                                                                                                    
[25576] "Non-Receptor_Type_6_Protein_Tyrosine_Phosphatase"                                                                                                                     
[25577] "Large_Tumor_Suppressor_Homolog-1_Protein"                                                                                                                             
[25578] "Non-Receptor_Type_7_Protein_Tyrosine_Phosphatase"                                                                                                                     
[25579] "Large_Tumor_Suppressor_Homolog-2_Protein"                                                                                                                             
[25580] "Lymphocyte_Cytosolic_Protein-2"                                                                                                                                       
[25581] "Left-Right_Determination_Factor-B"                                                                                                                                    
[25582] "Leptin_Receptor"                                                                                                                                                      
[25583] "CCNB1_Gene"                                                                                                                                                           
[25584] "Galectin-3_Binding_Protein"                                                                                                                                           
[25585] "Galectin-8_Protein"                                                                                                                                                   
[25586] "Leucine-Rich_Glioma-Inactivated_Protein"                                                                                                                              
[25587] "LIM_Homeobox_Protein-1"                                                                                                                                               
[25588] "LIM_Homeobox_Protein-2"                                                                                                                                               
[25589] "Hippocalcin"                                                                                                                                                          
[25590] "DEAD-H_Box_Protein-26"                                                                                                                                                
[25591] "Array"                                                                                                                                                                
[25592] "Serving"                                                                                                                                                              
[25593] "MAP_Kinase_Gene"                                                                                                                                                      
[25594] "MAP-Kinase-11"                                                                                                                                                        
[25595] "MAP-Kinase-10"                                                                                                                                                        
[25596] "MAP-Kinase-12"                                                                                                                                                        
[25597] "MAP-Kinase-13"                                                                                                                                                        
[25598] "MAP-Kinase-14"                                                                                                                                                        
[25599] "MAP-Kinase-4"                                                                                                                                                         
[25600] "MAP-Kinase-6"                                                                                                                                                         
[25601] "HIF1A_Gene"                                                                                                                                                           
[25602] "ARNT_Gene"                                                                                                                                                            
[25603] "ARNT2_Gene"                                                                                                                                                           
[25604] "Growth_Differentiation_Factor-9"                                                                                                                                      
[25605] "Post-Replication_Modification"                                                                                                                                        
[25606] "DNA_Methylation_Regulation"                                                                                                                                           
[25607] "MAP-Kinase-7"                                                                                                                                                         
[25608] "MAP-Kinase-9"                                                                                                                                                         
[25609] "APC-Binding_Protein-EB1"                                                                                                                                              
[25610] "Neurite_Growth-Promoting_Factor-2"                                                                                                                                    
[25611] "Homeobox_Protein-MEIS1"                                                                                                                                               
[25612] "Receptor_Tyrosine_Kinase-MERTK"                                                                                                                                       
[25613] "Growth_Factor_Independence-1B_Protein"                                                                                                                                
[25614] "_1q41-q44"                                                                                                                                                            
[25615] "_15q26"                                                                                                                                                               
[25616] "Exercise_Pain_Management"                                                                                                                                             
[25617] "Milk_Fat_Globule-EGF_Factor-8_Protein"                                                                                                                                
[25618] "GDNF_Family_Receptor_Alpha-2"                                                                                                                                         
[25619] "Mouse_Disorder_by_Site"                                                                                                                                               
[25620] "Mouse_Cardiovascular_System_Disorder"                                                                                                                                 
[25621] "Mouse_Connective_and_Soft_Tissue_Disorder"                                                                                                                            
[25622] "Mouse_Digestive_System_Disorder"                                                                                                                                      
[25623] "Mouse_Endocrine_Gland_System_Disorder"                                                                                                                                
[25624] "Mouse_Urinary_Tract_Disorder"                                                                                                                                         
[25625] "Mouse_Reproductive_System_Disorder"                                                                                                                                   
[25626] "Mouse_Female_Reproductive_System_Disorder"                                                                                                                            
[25627] "Protein_Splicing"                                                                                                                                                     
[25628] "Mouse_Male_Reproductive_System_Disorder"                                                                                                                              
[25629] "Mouse_Prostate_Disorder"                                                                                                                                              
[25630] "Mouse_Head_and_Neck_Disorder"                                                                                                                                         
[25631] "Mouse_Hematologic_Disorder"                                                                                                                                           
[25632] "Mouse_Mammary_Gland_Disorder"                                                                                                                                         
[25633] "Mouse_Skin_Disorder"                                                                                                                                                  
[25634] "Mouse_Nervous_System_Disorder"                                                                                                                                        
[25635] "Mouse_Respiratory_System_Disorder"                                                                                                                                    
[25636] "Mouse_Skeletal_System_Disorder"                                                                                                                                       
[25637] "Body_Fluids_and_Substances_MMHCC"                                                                                                                                     
[25638] "Urine_MMHCC"                                                                                                                                                          
[25639] "Pleural_Fluid_MMHCC"                                                                                                                                                  
[25640] "Mucus_MMHCC"                                                                                                                                                          
[25641] "Sebum_MMHCC"                                                                                                                                                          
[25642] "Sputum_MMHCC"                                                                                                                                                         
[25643] "Stool_MMHCC"                                                                                                                                                          
[25644] "Discharge_MMHCC"                                                                                                                                                      
[25645] "Exudate_MMHCC"                                                                                                                                                        
[25646] "T-Cell_Receptor_Beta_Locus"                                                                                                                                           
[25647] "T-Cell_Receptor_Alpha_Locus"                                                                                                                                          
[25648] "T-Cell_Receptor_Delta_Locus"                                                                                                                                          
[25649] "T-Cell_Receptor_Gamma_Locus"                                                                                                                                          
[25650] "Immunoglobulin_Heavy_Locus"                                                                                                                                           
[25651] "Immunoglobulin_Lambda_Locus"                                                                                                                                          
[25652] "_22q11_1-q11_2"                                                                                                                                                       
[25653] "Immunoglobulin_Kappa_Locus"                                                                                                                                           
[25654] "T-Cell_Receptor_Alpha_Chain"                                                                                                                                          
[25655] "T-Cell_Receptor_Beta_Chain"                                                                                                                                           
[25656] "T-Cell_Receptor_Gamma_Chain"                                                                                                                                          
[25657] "T-Cell_Receptor_Delta_Chain"                                                                                                                                          
[25658] "NFKBIA_Gene"                                                                                                                                                          
[25659] "Coronavirus"                                                                                                                                                          
[25660] "GLTSCR1_Protein"                                                                                                                                                      
[25661] "GLTSCR2-p60_Protein"                                                                                                                                                  
[25662] "_4q25-q31"                                                                                                                                                            
[25663] "_5q12"                                                                                                                                                                
[25664] "_8q22_1"                                                                                                                                                              
[25665] "_15q24"                                                                                                                                                               
[25666] "Conation"                                                                                                                                                             
[25667] "MDX-060_Monoclonal_Antibody"                                                                                                                                          
[25668] "I_131_Monoclonal_Antibody_CC49"                                                                                                                                       
[25669] "_14q21-q24"                                                                                                                                                           
[25670] "Adenovirus_5-Tumor_Necrosis_Factor_Alpha"                                                                                                                             
[25671] "Autologous_Dendritic_Cell-Adenovirus_P53_Vaccine"                                                                                                                     
[25672] "Dendritic_Cell-Autologous_Lung_Tumor_Vaccine"                                                                                                                         
[25673] "IDEC-114_Monoclonal_Antibody"                                                                                                                                         
[25674] "IDEC-152_Monoclonal_Antibody"                                                                                                                                         
[25675] "Monoclonal_Antibody_ACA125_Anti-Idiotype_Vaccine"                                                                                                                     
[25676] "Monoclonal_Antibody_GD2_Anti-Idiotype_Vaccine"                                                                                                                        
[25677] "Anthraquinone"                                                                                                                                                        
[25678] "Comedo"                                                                                                                                                               
[25679] "Dopaminergic_Cell"                                                                                                                                                    
[25680] "Luminal"                                                                                                                                                              
[25681] "Mixed_normal_and_tumor"                                                                                                                                               
[25682] "Intraductal_Hyperplasia"                                                                                                                                              
[25683] "Uncharacterized_Histology"                                                                                                                                            
[25684] "Animal_Cap"                                                                                                                                                           
[25685] "Dorsal_Lip"                                                                                                                                                           
[25686] "Endomesoderm"                                                                                                                                                         
[25687] "Fovea_Centralis"                                                                                                                                                      
[25688] "Macula"                                                                                                                                                               
[25689] "Corpus_Luteum"                                                                                                                                                        
[25690] "Mesonephros"                                                                                                                                                          
[25691] "Vesicular_Gland"                                                                                                                                                      
[25692] "Mesonephric_Duct"                                                                                                                                                     
[25693] "Maxilla"                                                                                                                                                              
[25694] "_2q21_1"                                                                                                                                                              
[25695] "_7q31_1-q31_3"                                                                                                                                                        
[25696] "_12p13_2-p12_3"                                                                                                                                                       
[25697] "Stratifin"                                                                                                                                                            
[25698] "_17q24_3"                                                                                                                                                             
[25699] "Transforming_Acidic_Coiled-Coil_Containing_Protein-2"                                                                                                                 
[25700] "NKRP1A_Protein"                                                                                                                                                       
[25701] "CD94_Antigen"                                                                                                                                                         
[25702] "MADD_Protein"                                                                                                                                                         
[25703] "SMAD2_Protein"                                                                                                                                                        
[25704] "SMAD6_Protein"                                                                                                                                                        
[25705] "SMAD7_Protein"                                                                                                                                                        
[25706] "SARA_Protein"                                                                                                                                                         
[25707] "NRAGE_Protein"                                                                                                                                                        
[25708] "MKK6_Protein"                                                                                                                                                         
[25709] "MEKK1_Protein"                                                                                                                                                        
[25710] "Serine-Threonine_Protein_Kinase-NIK"                                                                                                                                  
[25711] "TAK1_Protein"                                                                                                                                                         
[25712] "TAK1-Binding_Protein-1"                                                                                                                                               
[25713] "HGK_Protein"                                                                                                                                                          
[25714] "RECQL_Gene"                                                                                                                                                           
[25715] "RECQL4_Gene"                                                                                                                                                          
[25716] "RECQL5_Gene"                                                                                                                                                          
[25717] "_17q25_2-q25_3"                                                                                                                                                       
[25718] "HDAC1_Gene"                                                                                                                                                           
[25719] "HDAC2_Gene"                                                                                                                                                           
[25720] "HDAC3_Gene"                                                                                                                                                           
[25721] "HDAC4_Gene"                                                                                                                                                           
[25722] "_2q37_2"                                                                                                                                                              
[25723] "HDAC6_Gene"                                                                                                                                                           
[25724] "CYP19A1_Gene"                                                                                                                                                         
[25725] "_15q21_1"                                                                                                                                                             
[25726] "Deacetylase"                                                                                                                                                          
[25727] "SPAM1_Gene"                                                                                                                                                           
[25728] "_7q31_3"                                                                                                                                                              
[25729] "EPHX1_Gene"                                                                                                                                                           
[25730] "ACPP_Gene"                                                                                                                                                            
[25731] "MMP9_Gene"                                                                                                                                                            
[25732] "_20q11_2-q13_1"                                                                                                                                                       
[25733] "MMP3_Gene"                                                                                                                                                            
[25734] "Cytochrome_P450_Family_Gene"                                                                                                                                          
[25735] "CYP2C19_Gene"                                                                                                                                                         
[25736] "CYP2C18_Gene"                                                                                                                                                         
[25737] "MMP2_Gene"                                                                                                                                                            
[25738] "_16q13-q21"                                                                                                                                                           
[25739] "_10q24_1-q24_3"                                                                                                                                                       
[25740] "CYP2D6_Gene"                                                                                                                                                          
[25741] "CYP1A2_Gene"                                                                                                                                                          
[25742] "_15q22-qter"                                                                                                                                                          
[25743] "_16q24_1-q24_2"                                                                                                                                                       
[25744] "HSD17B2_Gene"                                                                                                                                                         
[25745] "_16q2"                                                                                                                                                                
[25746] "G6PD_Gene"                                                                                                                                                            
[25747] "TPO_Gene"                                                                                                                                                             
[25748] "_2p25"                                                                                                                                                                
[25749] "Mouse_Protein"                                                                                                                                                        
[25750] "Xenobiotic_Metabolism"                                                                                                                                                
[25751] "Rat_Protein"                                                                                                                                                          
[25752] "ZAP-70_Gene"                                                                                                                                                          
[25753] "SYK_Gene"                                                                                                                                                             
[25754] "DHODH_Gene"                                                                                                                                                           
[25755] "DHFR_Gene"                                                                                                                                                            
[25756] "BLK_Gene"                                                                                                                                                             
[25757] "_5q11_2-q13_2"                                                                                                                                                        
[25758] "_8p23-p22"                                                                                                                                                            
[25759] "DPYD_Gene"                                                                                                                                                            
[25760] "ADAM15_Gene"                                                                                                                                                          
[25761] "_1q21_3"                                                                                                                                                              
[25762] "PLAT_Gene"                                                                                                                                                            
[25763] "_8p12"                                                                                                                                                                
[25764] "Gene_Product"                                                                                                                                                         
[25765] "Functional_RNA"                                                                                                                                                       
[25766] "NRG3_Gene"                                                                                                                                                            
[25767] "Caspase_Gene"                                                                                                                                                         
[25768] "CASP1_Gene"                                                                                                                                                           
[25769] "Generation_of_Antibody_Diversity"                                                                                                                                     
[25770] "DNTT_Gene"                                                                                                                                                            
[25771] "_10q23-q24"                                                                                                                                                           
[25772] "PRIM1_Gene"                                                                                                                                                           
[25773] "PRIM2B_Gene"                                                                                                                                                          
[25774] "_6p12-p11_1"                                                                                                                                                          
[25775] "Primase_Polypeptide-2B"                                                                                                                                               
[25776] "Primase_Polypeptide-1"                                                                                                                                                
[25777] "Ethylnitrosourea"                                                                                                                                                     
[25778] "FASN_Gene"                                                                                                                                                            
[25779] "Fatty_Acid_Metabolism"                                                                                                                                                
[25780] "CASP2_Gene"                                                                                                                                                           
[25781] "NMT2_Gene"                                                                                                                                                            
[25782] "CREBBP_Gene"                                                                                                                                                          
[25783] "EP300_Gene"                                                                                                                                                           
[25784] "HAT1_Gene"                                                                                                                                                            
[25785] "_2q31_2-q33_1"                                                                                                                                                        
[25786] "PCAF_Gene"                                                                                                                                                            
[25787] "CASP3_Gene"                                                                                                                                                           
[25788] "HTATIP_Gene"                                                                                                                                                          
[25789] "_4q34"                                                                                                                                                                
[25790] "_11q12_1"                                                                                                                                                             
[25791] "FGF9_Gene"                                                                                                                                                            
[25792] "PLAU_Gene"                                                                                                                                                            
[25793] "FAP_Gene"                                                                                                                                                             
[25794] "_2q23"                                                                                                                                                                
[25795] "KLK2_Gene"                                                                                                                                                            
[25796] "KLK3_Gene"                                                                                                                                                            
[25797] "ST14_Gene"                                                                                                                                                            
[25798] "_11q24-q25"                                                                                                                                                           
[25799] "PRSS8_Gene"                                                                                                                                                           
[25800] "PRTN3_Gene"                                                                                                                                                           
[25801] "GPI_Gene"                                                                                                                                                             
[25802] "TOP1_Gene"                                                                                                                                                            
[25803] "TOP2A_Gene"                                                                                                                                                           
[25804] "TOP2B_Gene"                                                                                                                                                           
[25805] "TOP3A_Gene"                                                                                                                                                           
[25806] "_17p12-17p11_2"                                                                                                                                                       
[25807] "PTGS1_Gene"                                                                                                                                                           
[25808] "_9q32-q33_3"                                                                                                                                                          
[25809] "PTGS2_Gene"                                                                                                                                                           
[25810] "_1q25_2-q25_3"                                                                                                                                                        
[25811] "PF4_Gene"                                                                                                                                                             
[25812] "_4q12-q21"                                                                                                                                                            
[25813] "FOSB_Protein"                                                                                                                                                         
[25814] "FOSB_Gene"                                                                                                                                                            
[25815] "_19q13_32"                                                                                                                                                            
[25816] "ATF2_Gene"                                                                                                                                                            
[25817] "Pro-Platelet_Basic_Protein"                                                                                                                                           
[25818] "PPBP_Gene"                                                                                                                                                            
[25819] "Activin_A_Receptor_Type-I"                                                                                                                                            
[25820] "Activin-A_Receptor_Type-II-Like-1_Protein"                                                                                                                            
[25821] "Neutrophil-Activating_Peptide-2"                                                                                                                                      
[25822] "Adrenergic_Alpha-1A-Receptor"                                                                                                                                         
[25823] "RRM2_Gene"                                                                                                                                                            
[25824] "_2p25-p24"                                                                                                                                                            
[25825] "Alpha_Granule"                                                                                                                                                        
[25826] "ANG_Gene"                                                                                                                                                             
[25827] "_14q11_1-q11_2"                                                                                                                                                       
[25828] "Ribonucleoside-Diphosphate_Reductase-M2_Chain"                                                                                                                        
[25829] "CASP8_Gene"                                                                                                                                                           
[25830] "Interferon_Regulatory_Factor-3"                                                                                                                                       
[25831] "Interferon_Regulatory_Factor-2"                                                                                                                                       
[25832] "Interferon_Regulatory_Factor-1"                                                                                                                                       
[25833] "_3p25_3"                                                                                                                                                              
[25834] "_12q14_1"                                                                                                                                                             
[25835] "POR_Gene"                                                                                                                                                             
[25836] "_7q11_2"                                                                                                                                                              
[25837] "Follistatin-Like-3_Glycoprotein"                                                                                                                                      
[25838] "Drug_Metabolism"                                                                                                                                                      
[25839] "BAI1-Associated_Protein-2"                                                                                                                                            
[25840] "BLNK_Gene"                                                                                                                                                            
[25841] "B-Cell_Linker"                                                                                                                                                        
[25842] "Immunoglobulin_Binding_Protein-1"                                                                                                                                     
[25843] "Clofarabine"                                                                                                                                                          
[25844] "Epoetin_Beta"                                                                                                                                                         
[25845] "CMV_pp65_Peptide"                                                                                                                                                     
[25846] "Buspirone"                                                                                                                                                            
[25847] "Dexmethylphenidate"                                                                                                                                                   
[25848] "Dextroamphetamine-Amphetamine"                                                                                                                                        
[25849] "E7389"                                                                                                                                                                
[25850] "EP-2101"                                                                                                                                                              
[25851] "EGb761"                                                                                                                                                               
[25852] "Black_Cohosh"                                                                                                                                                         
[25853] "CP-724_714"                                                                                                                                                           
[25854] "Essiac"                                                                                                                                                               
[25855] "Flaxseed"                                                                                                                                                             
[25856] "Ginseng"                                                                                                                                                              
[25857] "GTI-2040"                                                                                                                                                             
[25858] "GW572016"                                                                                                                                                             
[25859] "Hexyl_5-Aminolevulinate"                                                                                                                                              
[25860] "Immucillin-H"                                                                                                                                                         
[25861] "Juven"                                                                                                                                                                
[25862] "Levocarnitine"                                                                                                                                                        
[25863] "LY317615"                                                                                                                                                             
[25864] "Marijuana"                                                                                                                                                            
[25865] "MLN2704"                                                                                                                                                              
[25866] "Modafinil"                                                                                                                                                            
[25867] "Morinda_citrifolia"                                                                                                                                                   
[25868] "Pixantrone"                                                                                                                                                           
[25869] "Camptothecin_Polyglutamate"                                                                                                                                           
[25870] "Pomegranate_Juice"                                                                                                                                                    
[25871] "R-flurbiprofen"                                                                                                                                                       
[25872] "Zileuton"                                                                                                                                                             
[25873] "RK-0202"                                                                                                                                                              
[25874] "Seocalcitol"                                                                                                                                                          
[25875] "Sildenafil_Citrate"                                                                                                                                                   
[25876] "Silymarin"                                                                                                                                                            
[25877] "Soblidotin"                                                                                                                                                           
[25878] "SU11248"                                                                                                                                                              
[25879] "T900607"                                                                                                                                                              
[25880] "Taporfin_Sodium"                                                                                                                                                      
[25881] "Transferrin-CRM107"                                                                                                                                                   
[25882] "Virulizin"                                                                                                                                                            
[25883] "YM598"                                                                                                                                                                
[25884] "GW786034"                                                                                                                                                             
[25885] "NY-ESO-B"                                                                                                                                                             
[25886] "HPV_18E6"                                                                                                                                                             
[25887] "Abdominal_Pain"                                                                                                                                                       
[25888] "Abnormal_Laboratory_Test"                                                                                                                                             
[25889] "Radiation-Induced_Abnormalities"                                                                                                                                      
[25890] "Premature_Separation_of_Placenta"                                                                                                                                     
[25891] "Abscess"                                                                                                                                                              
[25892] "Acanthosis_Nigricans"                                                                                                                                                 
[25893] "Acute_Laryngitis"                                                                                                                                                     
[25894] "Addison_s_Disease"                                                                                                                                                    
[25895] "Adrenal_Gland_Disorder"                                                                                                                                               
[25896] "Adrenal_Gland_Insufficiency"                                                                                                                                          
[25897] "Factor_I_Deficiency"                                                                                                                                                  
[25898] "Aneurysm"                                                                                                                                                             
[25899] "Dissecting_Aneurysm"                                                                                                                                                  
[25900] "Anal_Disorder"                                                                                                                                                        
[25901] "Anxiety"                                                                                                                                                              
[25902] "Aortic_Aneurysm"                                                                                                                                                      
[25903] "Apnea"                                                                                                                                                                
[25904] "Bacterial_Arthritis"                                                                                                                                                  
[25905] "Infective_Arthritis"                                                                                                                                                  
[25906] "Septic_Arthritis"                                                                                                                                                     
[25907] "Ataxia"                                                                                                                                                               
[25908] "Atrioventricular_Block"                                                                                                                                               
[25909] "Bacterial_Pneumonia"                                                                                                                                                  
[25910] "Balanitis"                                                                                                                                                            
[25911] "Bartholin_s_Cyst"                                                                                                                                                     
[25912] "Bladder_Stone"                                                                                                                                                        
[25913] "Eyelid_Ptosis"                                                                                                                                                        
[25914] "Breast_Disorder"                                                                                                                                                      
[25915] "Bronchopneumonia"                                                                                                                                                     
[25916] "Candidiasis"                                                                                                                                                          
[25917] "Mucinous_Adenocarcinoma"                                                                                                                                              
[25918] "Cataract"                                                                                                                                                             
[25919] "Celiac_Disease"                                                                                                                                                       
[25920] "Cellulitis"                                                                                                                                                           
[25921] "Cervicitis"                                                                                                                                                           
[25922] "Chalazion"                                                                                                                                                            
[25923] "Cholangitis"                                                                                                                                                          
[25924] "Chondrocalcinosis"                                                                                                                                                    
[25925] "Chorioamnionitis"                                                                                                                                                     
[25926] "Hemophilia_B"                                                                                                                                                         
[25927] "Chronic_Bronchitis"                                                                                                                                                   
[25928] "Colitis"                                                                                                                                                              
[25929] "Colles_Fracture"                                                                                                                                                      
[25930] "Common_Variable_Immunodeficiency"                                                                                                                                     
[25931] "Infectious_Disorder"                                                                                                                                                  
[25932] "Transplanted_Organ_Complication"                                                                                                                                      
[25933] "Conjunctival_Haemorrhage"                                                                                                                                             
[25934] "Connective_Tissue_Disorder"                                                                                                                                           
[25935] "Corneal_Abrasion"                                                                                                                                                     
[25936] "Corneal_Disorder"                                                                                                                                                     
[25937] "Coronary_Disease"                                                                                                                                                     
[25938] "Cranial_Nerve_Disorder"                                                                                                                                               
[25939] "Congenital_Hypothyroidism"                                                                                                                                            
[25940] "Croup"                                                                                                                                                                
[25941] "Cryoglobulinemia"                                                                                                                                                     
[25942] "Cyanosis"                                                                                                                                                             
[25943] "Cystitis"                                                                                                                                                             
[25944] "Sensorineural_Deafness"                                                                                                                                               
[25945] "Dehydration"                                                                                                                                                          
[25946] "Delusion"                                                                                                                                                             
[25947] "Dermatitis_Herpetiformis"                                                                                                                                             
[25948] "Contact_Dermatitis"                                                                                                                                                   
[25949] "Dermatomyositis"                                                                                                                                                      
[25950] "Dermatophytosis"                                                                                                                                                      
[25951] "Scleroderma"                                                                                                                                                          
[25952] "Non-Insulin_Dependent_Diabetes_Mellitus"                                                                                                                              
[25953] "Diabetic_Neuropathy"                                                                                                                                                  
[25954] "Vasoactive_Intestinal_Peptide_Producing_Neoplasm"                                                                                                                     
[25955] "Joint_Dislocation"                                                                                                                                                    
[25956] "Dissecting_Aortic_Aneurysm"                                                                                                                                           
[25957] "Diverticulitis"                                                                                                                                                       
[25958] "Diverticulum"                                                                                                                                                         
[25959] "Somnolence"                                                                                                                                                           
[25960] "Duodenal_Ulcer"                                                                                                                                                       
[25961] "Dyspepsia"                                                                                                                                                            
[25962] "Ear_Disorder"                                                                                                                                                         
[25963] "Ecchymosis"                                                                                                                                                           
[25964] "Embolism"                                                                                                                                                             
[25965] "Encephalitis"                                                                                                                                                         
[25966] "Encephalitis_Lethargica"                                                                                                                                              
[25967] "Endocervicitis"                                                                                                                                                       
[25968] "Fallopian_Tube_Endometriosis"                                                                                                                                         
[25969] "Endometritis"                                                                                                                                                         
[25970] "Enteritis"                                                                                                                                                            
[25971] "Epistaxis"                                                                                                                                                            
[25972] "Eye_Disorder"                                                                                                                                                         
[25973] "Eyelid_Disorder"                                                                                                                                                      
[25974] "Facial_Nerve_Paralysis"                                                                                                                                               
[25975] "Factor_XII_Deficiency"                                                                                                                                                
[25976] "Fallopian_Tube_Disorder"                                                                                                                                              
[25977] "Fat_Necrosis"                                                                                                                                                         
[25978] "Feminization"                                                                                                                                                         
[25979] "Femur_Fracture"                                                                                                                                                       
[25980] "Flushing"                                                                                                                                                             
[25981] "Solitary_Follicle_Cyst"                                                                                                                                               
[25982] "Carpal_Bone_Fracture"                                                                                                                                                 
[25983] "Multiple_Fractures"                                                                                                                                                   
[25984] "Stress_Fracture"                                                                                                                                                      
[25985] "Gastritis"                                                                                                                                                            
[25986] "Gastroesophageal_Reflux_Disease"                                                                                                                                      
[25987] "Glaucoma"                                                                                                                                                             
[25988] "Gliosis"                                                                                                                                                              
[25989] "Glomerulonephritis"                                                                                                                                                   
[25990] "Goiter"                                                                                                                                                               
[25991] "Gonadal_Disorder"                                                                                                                                                     
[25992] "Gonococcal_Urethritis"                                                                                                                                                
[25993] "Chronic_Granulomatous_Disease"                                                                                                                                        
[25994] "Granulomatous_Prostatitis"                                                                                                                                            
[25995] "Acute_Infective_Polyneuritis"                                                                                                                                         
[25996] "Hemorrhage"                                                                                                                                                           
[25997] "Hemorrhoid"                                                                                                                                                           
[25998] "Hepatic_Veno-Occlusive_Disease"                                                                                                                                       
[25999] "Hip_Fracture"                                                                                                                                                         
[26000] "Humerus_Fracture"                                                                                                                                                     
[26001] "Hydronephrosis"                                                                                                                                                       
[26002] "Hyperglycemia"                                                                                                                                                        
[26003] "Hypophosphatasia"                                                                                                                                                     
[26004] "Factor_II_Deficiency"                                                                                                                                                 
[26005] "Hypothyroidism"                                                                                                                                                       
[26006] "Intestinal_Disorder"                                                                                                                                                  
[26007] "Creutzfeldt-Jacob_Disease"                                                                                                                                            
[26008] "Jaw_Fracture"                                                                                                                                                         
[26009] "Joint_Tuberculosis"                                                                                                                                                   
[26010] "Keratitis"                                                                                                                                                            
[26011] "Keratoconus"                                                                                                                                                          
[26012] "Renal_Stone"                                                                                                                                                          
[26013] "Acute_Renal_Failure"                                                                                                                                                  
[26014] "Lacrimal_System_Disorder"                                                                                                                                             
[26015] "Laryngeal_Disorder"                                                                                                                                                   
[26016] "Laryngitis"                                                                                                                                                           
[26017] "Lens_Disorder"                                                                                                                                                        
[26018] "Acute_Eosinophilic_Leukemia"                                                                                                                                          
[26019] "Radiation-Related_Leukemia"                                                                                                                                           
[26020] "Progressive_Multifocal_Leukoencephalopathy"                                                                                                                           
[26021] "Leukopenia"                                                                                                                                                           
[26022] "Lichen_Sclerosus_et_Atrophicus"                                                                                                                                       
[26023] "Lip_Disorder"                                                                                                                                                         
[26024] "Cutaneous_Lupus_Erythematosus"                                                                                                                                        
[26025] "Discoid_Lupus_Erythematosus"                                                                                                                                          
[26026] "Lymphadenitis"                                                                                                                                                        
[26027] "Lymphogranuloma_Venereum"                                                                                                                                             
[26028] "Lymphopenia"                                                                                                                                                          
[26029] "Mandible_Fracture"                                                                                                                                                    
[26030] "Mediastinal_Disorder"                                                                                                                                                 
[26031] "Mediastinitis"                                                                                                                                                        
[26032] "Meningitis"                                                                                                                                                           
[26033] "Menorrhagia"                                                                                                                                                          
[26034] "Mesenteric_Lymphadenitis"                                                                                                                                             
[26035] "Mycobacterial_Infection"                                                                                                                                              
[26036] "Myelitis"                                                                                                                                                             
[26037] "Nephritis"                                                                                                                                                            
[26038] "Interstitial_Nephritis"                                                                                                                                               
[26039] "Nervous_System_Disorder"                                                                                                                                              
[26040] "Nutritional_Disorder"                                                                                                                                                 
[26041] "Osteogenesis_Imperfecta"                                                                                                                                              
[26042] "Osteomalacia"                                                                                                                                                         
[26043] "Bone_Infection"                                                                                                                                                       
[26044] "Osteopetrosis"                                                                                                                                                        
[26045] "Ovarian_Disorder"                                                                                                                                                     
[26046] "Pancreatic_Disorder"                                                                                                                                                  
[26047] "Paranasal_Sinus_Disorder"                                                                                                                                             
[26048] "Parathyroid_Gland_Disorder"                                                                                                                                           
[26049] "Parkinson_s_Disease"                                                                                                                                                  
[26050] "Penile_Disorder"                                                                                                                                                      
[26051] "Polyarteritis_Nodosa"                                                                                                                                                 
[26052] "Peritoneal_Disorder"                                                                                                                                                  
[26053] "Peritonitis"                                                                                                                                                          
[26054] "Pharyngeal_Disorder"                                                                                                                                                  
[26055] "Pharyngitis"                                                                                                                                                          
[26056] "Phimosis"                                                                                                                                                             
[26057] "Pituitary_Apoplexy"                                                                                                                                                   
[26058] "Pituitary_Gland_Disorder"                                                                                                                                             
[26059] "Pityriasis_Rosea"                                                                                                                                                     
[26060] "Placenta_Accreta"                                                                                                                                                     
[26061] "Placenta_Disorder"                                                                                                                                                    
[26062] "Placenta_Previa"                                                                                                                                                      
[26063] "Pleural_Disorder"                                                                                                                                                     
[26064] "Pleuritis"                                                                                                                                                            
[26065] "Pneumoconiosis"                                                                                                                                                       
[26066] "Stein-Leventhal_Syndrome"                                                                                                                                             
[26067] "Polycythemia"                                                                                                                                                         
[26068] "Polyneuritis"                                                                                                                                                         
[26069] "Prostate_Disorder"                                                                                                                                                    
[26070] "Prostatitis"                                                                                                                                                          
[26071] "Kimura_s_Disease"                                                                                                                                                     
[26072] "Pulmonary_Edema"                                                                                                                                                      
[26073] "Pulmonary_Fibrosis"                                                                                                                                                   
[26074] "Thrombocytopenic_Purpura"                                                                                                                                             
[26075] "Respiratory_Disorder"                                                                                                                                                 
[26076] "Respiratory_Failure"                                                                                                                                                  
[26077] "Infectious_Lung_Disorder"                                                                                                                                             
[26078] "Retinal_Detachment"                                                                                                                                                   
[26079] "Retinal_Disorder"                                                                                                                                                     
[26080] "Retroperitoneal_Fibrosis"                                                                                                                                             
[26081] "Rheumatism"                                                                                                                                                           
[26082] "Rickets"                                                                                                                                                              
[26083] "Salivary_Gland_Disorder"                                                                                                                                              
[26084] "Salpingitis"                                                                                                                                                          
[26085] "Solar_Lentigo"                                                                                                                                                        
[26086] "Sialoadenitis"                                                                                                                                                        
[26087] "Sjogren_s_Syndrome"                                                                                                                                                   
[26088] "Sleep_Apnea"                                                                                                                                                          
[26089] "Testicular_Torsion"                                                                                                                                                   
[26090] "Stomach_Disorder"                                                                                                                                                     
[26091] "Stomatitis"                                                                                                                                                           
[26092] "Sinus_Tachycardia"                                                                                                                                                    
[26093] "Testicular_Disorder"                                                                                                                                                  
[26094] "Thrombosis"                                                                                                                                                           
[26095] "Thymic_Cyst"                                                                                                                                                          
[26096] "Thyroid_Gland_Disorder"                                                                                                                                               
[26097] "Thyroiditis"                                                                                                                                                          
[26098] "Tuberculous_Laryngitis"                                                                                                                                               
[26099] "Lymph_Node_Tuberculosis"                                                                                                                                              
[26100] "Bone_Tuberculosis"                                                                                                                                                    
[26101] "Tuberculosis_of_Pleura"                                                                                                                                               
[26102] "Lung_Tuberculosis"                                                                                                                                                    
[26103] "Turner_s_Syndrome"                                                                                                                                                    
[26104] "Erythema"                                                                                                                                                             
[26105] "Ureteric_Calculus"                                                                                                                                                    
[26106] "Urethra_Disorder"                                                                                                                                                     
[26107] "Urethritis"                                                                                                                                                           
[26108] "Urinary_Stone"                                                                                                                                                        
[26109] "Urinary_Frequency"                                                                                                                                                    
[26110] "Uterine_Disorder"                                                                                                                                                     
[26111] "Uveal_Disorder"                                                                                                                                                       
[26112] "Uveitis"                                                                                                                                                              
[26113] "Vaginal_Disorder"                                                                                                                                                     
[26114] "Vaginitis"                                                                                                                                                            
[26115] "Vasculitis"                                                                                                                                                           
[26116] "Verruca_Plantaris"                                                                                                                                                    
[26117] "Virilism"                                                                                                                                                             
[26118] "Vitiligo"                                                                                                                                                             
[26119] "Anticipatory_Vomiting"                                                                                                                                                
[26120] "Dry_Mouth"                                                                                                                                                            
[26121] "AIDS-Related_Nephropathy"                                                                                                                                             
[26122] "Lymphosarcoma"                                                                                                                                                        
[26123] "Encephalopathy"                                                                                                                                                       
[26124] "Fever_Chills"                                                                                                                                                         
[26125] "Hepatic_Failure"                                                                                                                                                      
[26126] "Sinus_Bradycardia"                                                                                                                                                    
[26127] "Ventricular_Arrhythmia"                                                                                                                                               
[26128] "Polymyositis"                                                                                                                                                         
[26129] "Alcoholic_Polyneuropathy"                                                                                                                                             
[26130] "Hydroureter"                                                                                                                                                          
[26131] "Hemorrhagic_Gastritis"                                                                                                                                                
[26132] "Chronic_Gastritis"                                                                                                                                                    
[26133] "Chronic_Prostatitis"                                                                                                                                                  
[26134] "Hypogammaglobulinemia"                                                                                                                                                
[26135] "Acute_Bronchitis"                                                                                                                                                     
[26136] "Acute_Gastritis"                                                                                                                                                      
[26137] "Acute_Cystitis"                                                                                                                                                       
[26138] "Acute_Prostatitis"                                                                                                                                                    
[26139] "Prostatic_Stone"                                                                                                                                                      
[26140] "Cervical_Lymphadenitis"                                                                                                                                               
[26141] "Fibula_Fracture"                                                                                                                                                      
[26142] "Coccyx_Fracture"                                                                                                                                                      
[26143] "Chronic_Pain"                                                                                                                                                         
[26144] "Cranial_Nerve_Paralysis"                                                                                                                                              
[26145] "Thyroid_Atrophy"                                                                                                                                                      
[26146] "Gamma-Glutamyltransferase_Increased"                                                                                                                                  
[26147] "Retroperitoneal_Hemorrhage"                                                                                                                                           
[26148] "Vaginal_Hemorrhage"                                                                                                                                                   
[26149] "Hepatocellular_Damage"                                                                                                                                                
[26150] "Aspartate_Aminotransferase_Increased"                                                                                                                                 
[26151] "Alanine_Aminotransferase_Increased"                                                                                                                                   
[26152] "Duodenal_Ulcer_Hemorrhage"                                                                                                                                            
[26153] "Esophageal_Ulcer"                                                                                                                                                     
[26154] "Polyneuropathy"                                                                                                                                                       
[26155] "Trigeminal_Nerve_Disorder"                                                                                                                                            
[26156] "Disorder_of_the_11th_Nerve"                                                                                                                                           
[26157] "Hypoglossal_Nerve_Disorder"                                                                                                                                           
[26158] "Familiar_Polycythemia"                                                                                                                                                
[26159] "Hodgkin_s_Paragranuloma"                                                                                                                                              
[26160] "Tuberculous_Bronchiectasis"                                                                                                                                           
[26161] "Adrenal_Gland_Tuberculosis"                                                                                                                                           
[26162] "Reticulosarcoma_Involving_Spleen"                                                                                                                                     
[26163] "Lymphosarcoma_Involving_Spleen"                                                                                                                                       
[26164] "Hodgkin_s_Paragranuloma_Involving_Spleen"                                                                                                                             
[26165] "Thymus_Disorder"                                                                                                                                                      
[26166] "Carotenemia"                                                                                                                                                          
[26167] "Selective_IgA_Immunodeficiency"                                                                                                                                       
[26168] "Selective_IgM_Immunodeficiency"                                                                                                                                       
[26169] "Chronic_Lymphadenitis"                                                                                                                                                
[26170] "Retinal_Detachment_and_Defect"                                                                                                                                        
[26171] "Retinal_Defect"                                                                                                                                                       
[26172] "Corneal_Abscess"                                                                                                                                                      
[26173] "Bullous_Keratopathy"                                                                                                                                                  
[26174] "Dacryoadenitis"                                                                                                                                                       
[26175] "External_Ear_Disorder"                                                                                                                                                
[26176] "Sensory_Hearing_Loss"                                                                                                                                                 
[26177] "Mixed_Conductive_and_Sensorineural_Deafness"                                                                                                                          
[26178] "Chronic_Laryngitis"                                                                                                                                                   
[26179] "Chronic_Obstructive_Asthma"                                                                                                                                           
[26180] "Alcoholic_Gastritis"                                                                                                                                                  
[26181] "Acute_Lymphadenitis"                                                                                                                                                  
[26182] "Juvenile_Chronic_Polyarthritis"                                                                                                                                       
[26183] "Allergic_Arthritis"                                                                                                                                                   
[26184] "Climacteric_Arthritis"                                                                                                                                                
[26185] "Pathologic_Joint_Dislocation"                                                                                                                                         
[26186] "Intervertebral_Disc_Degenerative_Disorder"                                                                                                                            
[26187] "Infective_Myositis"                                                                                                                                                   
[26188] "Interstitial_Myositis"                                                                                                                                                
[26189] "Pharyngeal_Hemorrhage"                                                                                                                                                
[26190] "Clavicle_Fracture"                                                                                                                                                    
[26191] "Forearm_Fracture"                                                                                                                                                     
[26192] "Ankle_Fracture"                                                                                                                                                       
[26193] "Transplanted_Kidney_Complication"                                                                                                                                     
[26194] "Transplanted_Liver_Complication"                                                                                                                                      
[26195] "Transplanted_Heart_Complication"                                                                                                                                      
[26196] "Transplanted_Lung_Complication"                                                                                                                                       
[26197] "Burn_of_Esophagus"                                                                                                                                                    
[26198] "Urethral_Stone"                                                                                                                                                       
[26199] "Polyarthritis"                                                                                                                                                        
[26200] "Hypertrophic_Scar"                                                                                                                                                    
[26201] "Allergic_Contact_Dermatitis"                                                                                                                                          
[26202] "Ruptured_Aneurysm"                                                                                                                                                    
[26203] "Abdominal_Aortic_Aneurysm"                                                                                                                                            
[26204] "Thoracic_Aortic_Aneurysm"                                                                                                                                             
[26205] "Lower_Extremity_Fracture"                                                                                                                                             
[26206] "Acute_Pain"                                                                                                                                                           
[26207] "Sarcomatoid_Carcinoma"                                                                                                                                                
[26208] "Spindle_Cell_Sarcoma"                                                                                                                                                 
[26209] "Interstitial_Pneumonitis"                                                                                                                                             
[26210] "Spitz_Spindle_Cell_Nevus"                                                                                                                                             
[26211] "Chronic_Cystitis"                                                                                                                                                     
[26212] "Myalgia"                                                                                                                                                              
[26213] "Sterile"                                                                                                                                                              
[26214] "Euphoric_Mood"                                                                                                                                                        
[26215] "Keratopathy"                                                                                                                                                          
[26216] "Erosive_Gastritis"                                                                                                                                                    
[26217] "Chemical_Esophagitis"                                                                                                                                                 
[26218] "Granulomatous_Hepatitis"                                                                                                                                              
[26219] "Submandibular_Lymphadenitis"                                                                                                                                          
[26220] "Aggravated_Arthritis"                                                                                                                                                 
[26221] "Acquired_Hemangioma"                                                                                                                                                  
[26222] "Male_Reproductive_System_Disorder"                                                                                                                                    
[26223] "Female_Reproductive_System_Disorder"                                                                                                                                  
[26224] "Collagenous_Colitis"                                                                                                                                                  
[26225] "Acute_Endometritis"                                                                                                                                                   
[26226] "Herpes_Esophagitis"                                                                                                                                                   
[26227] "Selective_Immunoglobulin_G_Subclass_Deficiency"                                                                                                                       
[26228] "Ischemic_Neuropathy"                                                                                                                                                  
[26229] "Talc_Pneumoconiosis"                                                                                                                                                  
[26230] "Candida_Esophagitis"                                                                                                                                                  
[26231] "Prolonged_Partial_Thromboplastin_Time"                                                                                                                                
[26232] "Autoimmune_Hepatitis"                                                                                                                                                 
[26233] "Cerebral_Abscess"                                                                                                                                                     
[26234] "Pancreatic_Endocrine_Neoplasm"                                                                                                                                        
[26235] "Anaplastic_Lymphoma_Kinase"                                                                                                                                           
[26236] "Autonomic_Neuropathy"                                                                                                                                                 
[26237] "Juvenile_Angiofibroma"                                                                                                                                                
[26238] "Lumbar_Vertebral_Fracture"                                                                                                                                            
[26239] "Nerve_Paralysis"                                                                                                                                                      
[26240] "Spongiotic_Dermatitis"                                                                                                                                                
[26241] "Hypereosinophilic_Syndrome"                                                                                                                                           
[26242] "Hemophilic_Arthritis"                                                                                                                                                 
[26243] "Spinal_Degenerative_Arthritis"                                                                                                                                        
[26244] "Neck_Arthritis"                                                                                                                                                       
[26245] "Soft_Tissue_Disorder"                                                                                                                                                 
[26246] "Acute_Respiratory_Failure"                                                                                                                                            
[26247] "Eosinophilic_Endomyocardial_Disease"                                                                                                                                  
[26248] "Nodal_Arrhythmia"                                                                                                                                                     
[26249] "Ruptured_Abdominal_Aortic_Aneurysm"                                                                                                                                   
[26250] "Connective_Tissue_Nevus"                                                                                                                                              
[26251] "Congenital_Eyelid_Malformation"                                                                                                                                       
[26252] "Congenital_Eyelid_Ptosis"                                                                                                                                             
[26253] "Placenta_Malformation"                                                                                                                                                
[26254] "Lymphocytic_Gastritis"                                                                                                                                                
[26255] "Eosinophilic_Gastritis"                                                                                                                                               
[26256] "Eosinophilic_Colitis"                                                                                                                                                 
[26257] "Rectal_Hemorrhage"                                                                                                                                                    
[26258] "Uremic_Neuropathy"                                                                                                                                                    
[26259] "Acute_Cervicitis"                                                                                                                                                     
[26260] "Chronic_Cervicitis"                                                                                                                                                   
[26261] "Brain_Damage"                                                                                                                                                         
[26262] "Leukoencephalopathy"                                                                                                                                                  
[26263] "Radiation-Induced_Myelopathy"                                                                                                                                         
[26264] "Peroneal_Nerve_Paralysis"                                                                                                                                             
[26265] "Demyelinating_Polyneuropathy"                                                                                                                                         
[26266] "Toxic_Polyneuropathy"                                                                                                                                                 
[26267] "Radiation-Induced_Cataract"                                                                                                                                           
[26268] "Middle_Ear_Disorder"                                                                                                                                                  
[26269] "Pituitary_Necrosis"                                                                                                                                                   
[26270] "Endocrine_Pancreas_Disorder"                                                                                                                                          
[26271] "Diabetic_Autonomic_Neuropathy"                                                                                                                                        
[26272] "Polycythemia_Neonatorum"                                                                                                                                              
[26273] "Reticular_Dysgenesis"                                                                                                                                                 
[26274] "Transient_Hypogammaglobulinemia_of_Infancy"                                                                                                                           
[26275] "Finger_Fracture"                                                                                                                                                      
[26276] "Cranial_Nerve_Injury"                                                                                                                                                 
[26277] "Arthritis_or_Polyarthritis_due_to_Pneumococcus"                                                                                                                       
[26278] "Arthritis_or_Polyarthritis_due_to_Streptococcus"                                                                                                                      
[26279] "Tuberculous_Ascites"                                                                                                                                                  
[26280] "Arthritis_or_Polyarthritis_due_to_Pseudomonas"                                                                                                                        
[26281] "Arthritis_or_Polyarthritis_due_to_Escherichia_Coli"                                                                                                                   
[26282] "Non-Gonococcal_Urethritis"                                                                                                                                            
[26283] "Refractory_Anemia_with_Excess_Blasts_in_Transformation"                                                                                                               
[26284] "Juvenile_Pilocytic_Astrocytoma"                                                                                                                                       
[26285] "Radiation-Induced_Cerebritis"                                                                                                                                         
[26286] "Blood_Clot"                                                                                                                                                           
[26287] "Sarcomatoid_Squamous_Cell_Carcinoma"                                                                                                                                  
[26288] "Dissecting_Abdominal_Aortic_Aneurysm"                                                                                                                                 
[26289] "Polycystic_Ovarian_Disease"                                                                                                                                           
[26290] "Verruca_Vulgaris"                                                                                                                                                     
[26291] "Elevated_Bilirubin"                                                                                                                                                   
[26292] "Vesicle"                                                                                                                                                              
[26293] "Degenerative_Disorder"                                                                                                                                                
[26294] "Malignant_Spindle_Cell_Neoplasm"                                                                                                                                      
[26295] "Small_Cell_Carcinoma_Fusiform_Cell_Type"                                                                                                                              
[26296] "Stage_0_Squamous_Cell_Carcinoma"                                                                                                                                      
[26297] "Cylindroma"                                                                                                                                                           
[26298] "Nonpigmented_Nevus"                                                                                                                                                   
[26299] "Undifferentiated_Embryonal_Sarcoma"                                                                                                                                   
[26300] "Anaplastic_Variant_of_Spermatocytic_Seminoma"                                                                                                                         
[26301] "Hodgkin_s_Disease_Nodular_Sclerosis_Mixed_Cellularity"                                                                                                                
[26302] "Malignant_Lymphoma_Histiocytic_Diffuse"                                                                                                                               
[26303] "Actinomycotic_Cerebral_Abscess"                                                                                                                                       
[26304] "Cognitive_Disturbance"                                                                                                                                                
[26305] "Nasal_Cavity_Disorder"                                                                                                                                                
[26306] "Localized_Pulmonary_Fibrosis"                                                                                                                                         
[26307] "Radiation-Induced_Damage_to_Artery"                                                                                                                                   
[26308] "Eosinophilic_Esophagitis"                                                                                                                                             
[26309] "Bacterial_Esophagitis"                                                                                                                                                
[26310] "Fungal_Esophagitis"                                                                                                                                                   
[26311] "Viral_Esophagitis"                                                                                                                                                    
[26312] "Radiation-Induced_Esophageal_Stricture"                                                                                                                               
[26313] "Colitis_of_Indeterminate_Type"                                                                                                                                        
[26314] "Radiation_Colitis"                                                                                                                                                    
[26315] "Congenital_Thyroid_Aplasia"                                                                                                                                           
[26316] "Congenital_Thyroid_Hypoplasia"                                                                                                                                        
[26317] "Congenital_Hypothyroidism_with_Ectopic_Thyroid"                                                                                                                       
[26318] "Thyroid_Gland_Abscess"                                                                                                                                                
[26319] "Congenital_Iodine_Deficiency_Hypothyroidism"                                                                                                                          
[26320] "Pituitary_Infarction"                                                                                                                                                 
[26321] "Pituitary_Hemorrhage"                                                                                                                                                 
[26322] "Pituitary_Gland_Cyst"                                                                                                                                                 
[26323] "Electrolyte_Disorder"                                                                                                                                                 
[26324] "Helicobacter_Pylori-Associated_Gastritis"                                                                                                                             
[26325] "Endemic_Burkitt_s_Lymphoma"                                                                                                                                           
[26326] "Blurred_Vision"                                                                                                                                                       
[26327] "Congenital_Phimosis"                                                                                                                                                  
[26328] "Pilar_Tumor"                                                                                                                                                          
[26329] "Multiple_Pigmented_Terminal_Hair_Cysts"                                                                                                                               
[26330] "Benign_Cutaneous_Vascular_Neoplasm"                                                                                                                                   
[26331] "Adrenal_Gland_Injury"                                                                                                                                                 
[26332] "Acetabulum_Fracture"                                                                                                                                                  
[26333] "Ilium_Fracture"                                                                                                                                                       
[26334] "Early_Gastric_Cancer"                                                                                                                                                 
[26335] "Trichogenic_Trichoblastoma"                                                                                                                                           
[26336] "Prostate_Endometrioid_Carcinoma"                                                                                                                                      
[26337] "Hematopoietic_Cell_Neoplasm"                                                                                                                                          
[26338] "Suppurative_Lymphadenitis"                                                                                                                                            
[26339] "Placental_Necrosis"                                                                                                                                                   
[26340] "Radiation-Induced_Stomatitis"                                                                                                                                         
[26341] "Peritoneal_Hemorrhage"                                                                                                                                                
[26342] "Pyogenic_Arthritis"                                                                                                                                                   
[26343] "Ventricular_Aneurysm"                                                                                                                                                 
[26344] "Immunoglobulin_Heavy_Chain_Deletion"                                                                                                                                  
[26345] "Selective_IgG_Immunodeficiency"                                                                                                                                       
[26346] "Selective_IgE_Immunodeficiency"                                                                                                                                       
[26347] "Selective_IgD_Immunodeficiency"                                                                                                                                       
[26348] "T-Cell_Immunodeficiency"                                                                                                                                              
[26349] "Hemophilia_A"                                                                                                                                                         
[26350] "Lymphocytic_Colitis"                                                                                                                                                  
[26351] "Ureter_Disorder"                                                                                                                                                      
[26352] "Aquired_Phimosis"                                                                                                                                                     
[26353] "Adrenal_Cortical_Insufficiency"                                                                                                                                       
[26354] "Irritant_Contact_Dermatitis"                                                                                                                                          
[26355] "Sebaceous_Hyperplasia"                                                                                                                                                
[26356] "Lupus_Erythematosus"                                                                                                                                                  
[26357] "Lumbar_Disc_Degenerative_Disorder"                                                                                                                                    
[26358] "Thoracic_Disc_Degenerative_Disorder"                                                                                                                                  
[26359] "Cervical_Disc_Degenerative_Disorder"                                                                                                                                  
[26360] "Mouth_Sore"                                                                                                                                                           
[26361] "Supraventricular_Arrhythmia"                                                                                                                                          
[26362] "Gingival_Ecchymosis"                                                                                                                                                  
[26363] "Injury_of_Inner_Ear"                                                                                                                                                  
[26364] "Hand_Fracture"                                                                                                                                                        
[26365] "Non-Specific_Granulomatous_Orchitis"                                                                                                                                  
[26366] "Arthritis_or_Polyarthritis_due_to_Staphylococcus"                                                                                                                     
[26367] "Epiphyseal_Fracture"                                                                                                                                                  
[26368] "Respiratory_Distress"                                                                                                                                                 
[26369] "Inner_Ear_Disorder"                                                                                                                                                   
[26370] "Primary_Biliary_Cirrhosis"                                                                                                                                            
[26371] "Obstructive_Sleep_Apnea_Syndrome"                                                                                                                                     
[26372] "Central_Sleep_Apnea_Syndrome"                                                                                                                                         
[26373] "Compression_Fracture"                                                                                                                                                 
[26374] "Systemic_Lupus_Erythematosus_Rash"                                                                                                                                    
[26375] "Neonatal_Apneic_Attack"                                                                                                                                               
[26376] "Stress_Polycythemia"                                                                                                                                                  
[26377] "Injection_Site_Thrombophlebitis"                                                                                                                                      
[26378] "Accelerated_Neoplasm_Growth"                                                                                                                                          
[26379] "Palmar-Plantar_Erythodysthesia"                                                                                                                                       
[26380] "Secondary_Polycythemia"                                                                                                                                               
[26381] "Juvenile_Rheumatoid_Arthritis"                                                                                                                                        
[26382] "Radiation-Induced_Fibrous_Mediastinitis"                                                                                                                              
[26383] "Placental_Infarction"                                                                                                                                                 
[26384] "Morphea-Type_Sclerosing_Basal_Cell_Carcinoma"                                                                                                                         
[26385] "Adult_Spinal_Cord_Glioblastoma"                                                                                                                                       
[26386] "Viral_Gastritis"                                                                                                                                                      
[26387] "Disseminated_Adenocarcinoma"                                                                                                                                          
[26388] "Clinical_Finding"                                                                                                                                                     
[26389] "Inherited_Neuropathy"                                                                                                                                                 
[26390] "Radiation-Induced_Mosaicism"                                                                                                                                          
[26391] "Interstitial_Cystitis"                                                                                                                                                
[26392] "Elbow_Fracture"                                                                                                                                                       
[26393] "Hashimoto_s_Thyroiditis"                                                                                                                                              
[26394] "Regional_Enteritis"                                                                                                                                                   
[26395] "Ear_Infection"                                                                                                                                                        
[26396] "Brachial_Plexopathy"                                                                                                                                                  
[26397] "Acne"                                                                                                                                                                 
[26398] "Lupus_Encephalitis"                                                                                                                                                   
[26399] "Acute_Pneumonia"                                                                                                                                                      
[26400] "Ruptured_Aortic_Aneurysm"                                                                                                                                             
[26401] "Cerebritis"                                                                                                                                                           
[26402] "Gastric_Leiomyosarcoma"                                                                                                                                               
[26403] "Knee_Fracture"                                                                                                                                                        
[26404] "Invasive_Papillary_Urothelial_Carcinoma"                                                                                                                              
[26405] "Bacterial_Prostatitis"                                                                                                                                                
[26406] "Rheumatologic_Disorder"                                                                                                                                               
[26407] "Vertebral_Disc_Degenerative_Disorder"                                                                                                                                 
[26408] "Atrophic_Arthritis"                                                                                                                                                   
[26409] "Vestibulocochlear_Nerve_Disorder"                                                                                                                                     
[26410] "Brain_Aneurysm"                                                                                                                                                       
[26411] "Radiation-Related_Malignant_Neoplasm"                                                                                                                                 
[26412] "Olfactory_Nerve_Disorder"                                                                                                                                             
[26413] "Glossopharyngeal_Nerve_Disorder"                                                                                                                                      
[26414] "Glossopharyngeal_Motor_Neuropathy"                                                                                                                                    
[26415] "t_14_18_q32_q21"                                                                                                                                                      
[26416] "t_11_22_q24_q12_EWS-FLI1"                                                                                                                                             
[26417] "Coagulation_Factor_Deficiency"                                                                                                                                        
[26418] "Diffuse_Pulmonary_Fibrosis"                                                                                                                                           
[26419] "Cytomegalovirus-Related_Gastritis"                                                                                                                                    
[26420] "Cytomegalovirus_Esophagitis"                                                                                                                                          
[26421] "Viral_Respiratory_Tract_Infection"                                                                                                                                    
[26422] "Bone_Infarction"                                                                                                                                                      
[26423] "Entrapment_Neuropathy"                                                                                                                                                
[26424] "Cerebral_Aneurysm"                                                                                                                                                    
[26425] "Infection-Related_Malignant_Neoplasm"                                                                                                                                 
[26426] "Infection-Related_Neoplasm"                                                                                                                                           
[26427] "Environment-Related_Neoplasm"                                                                                                                                         
[26428] "Testicular_Feminization_Syndrome"                                                                                                                                     
[26429] "Neonatal_Leukopenia"                                                                                                                                                  
[26430] "Gonadal_Agenesis"                                                                                                                                                     
[26431] "Radiation_Induced_DNA_Damage_Retired"                                                                                                                                 
[26432] "Respiratory_Thoracic_and_Mediastinal_Neoplasm"                                                                                                                        
[26433] "Cardiovascular_Manifestation"                                                                                                                                         
[26434] "Blood_Test_Result"                                                                                                                                                    
[26435] "Transplant-Related_Disorder"                                                                                                                                          
[26436] "Nipple_Duct_Carcinoma"                                                                                                                                                
[26437] "Gastric_Non-Hodgkin_s_Lymphoma"                                                                                                                                       
[26438] "Tobacco-Related_Carcinoma"                                                                                                                                            
[26439] "Familial_Adenomatous_Polyposis_Associated_Medulloblastomas"                                                                                                           
[26440] "Low-Grade_Anal_Canal_Intraepithelial_Neoplasia"                                                                                                                       
[26441] "Low_Risk_Gastric_Gastrointestinal_Stromal_Tumor"                                                                                                                      
[26442] "High_Risk_Gastric_Gastrointestinal_Stromal_Tumor"                                                                                                                     
[26443] "Adult_Yolk_Sac_Tumor"                                                                                                                                                 
[26444] "Low_Risk_Gastrointestinal_Stromal_Tumor"                                                                                                                              
[26445] "High_Risk_Gastrointestinal_Stromal_Tumor"                                                                                                                             
[26446] "Low_Risk_Small_Intestinal_Gastrointestinal_Stromal_Tumor"                                                                                                             
[26447] "High_Risk_Small_Intestinal_Gastrointestinal_Stromal_Tumor"                                                                                                            
[26448] "Uterine_Corpus_Choriocarcinoma"                                                                                                                                       
[26449] "Stage_IVB_Vulvar_Cancer"                                                                                                                                              
[26450] "Cranial_Nodular_Fasciitis"                                                                                                                                            
[26451] "Non-Hodgkin_s_Lymphoma_Lymphoblastic_WF"                                                                                                                              
[26452] "Uterine_Corpus_Adenomatoid_Tumor"                                                                                                                                     
[26453] "PDQ_Antiquated_Neoplastic_Concept"                                                                                                                                    
[26454] "Enterochromaffin-Like_Cell_Carcinoid_Tumor"                                                                                                                           
[26455] "Metanephric_Adenoma"                                                                                                                                                  
[26456] "Eccrine_Papillary_Adenocarcinoma"                                                                                                                                     
[26457] "Eccrine_Adenocarcinoma"                                                                                                                                               
[26458] "Giant_Cell_Angiofibroma"                                                                                                                                              
[26459] "Cellular_Angiofibroma"                                                                                                                                                
[26460] "Malignant_Lymphoma_Non-Cleaved_Cell_Type"                                                                                                                             
[26461] "Malignant_Non-Hodgkin_s_Lymphoma_Diffuse_Lymphocytic_Poorly_Differentiated"                                                                                           
[26462] "Dendritic_Cell_Sarcoma_Not_Otherwise_Specified"                                                                                                                       
[26463] "Pre_T-ALL"                                                                                                                                                            
[26464] "Myelodysplastic_Myeloproliferative_Disease"                                                                                                                           
[26465] "Spindle_Cell_Neoplasm"                                                                                                                                                
[26466] "Familial_Atypical_Mole_Melanoma_Syndrome"                                                                                                                             
[26467] "Malignant_Lymphoma_Large_Cell_Cleaved"                                                                                                                                
[26468] "Malignant_Lymphoma_Non-Cleaved_Diffuse"                                                                                                                               
[26469] "Lymphoma_Leukemia_by_Kiel_Classification_Antiquated"                                                                                                                  
[26470] "Lymphoma_by_Stage"                                                                                                                                                    
[26471] "Glandular_Cell_Intraepithelial_Neoplasia"                                                                                                                             
[26472] "Hodgkin_s_Disease_Nodular_Sclerosis_Lymphocyte_Predominance"                                                                                                          
[26473] "Intermediate_Risk_Gastrointestinal_Stromal_Tumor"                                                                                                                     
[26474] "Malignant_Lymphoma_Large_Cell_Cleaved_and_Non-Cleaved"                                                                                                                
[26475] "Poroma_Acrospiroma"                                                                                                                                                   
[26476] "Premalignant_Hematologic_Condition"                                                                                                                                   
[26477] "High_Grade_Anal_Canal_Intraepithelial_Neoplasia"                                                                                                                      
[26478] "Increased_Atypical_Lymphocytes"                                                                                                                                       
[26479] "Arrhythmia_Requiring_Therapy"                                                                                                                                         
[26480] "L1_Adult_Acute_Lymphoblastic_Leukemia"                                                                                                                                
[26481] "Localized_Pheochromocytoma"                                                                                                                                           
[26482] "Secondary_Myelodysplastic_Syndrome"                                                                                                                                   
[26483] "FAB_L2"                                                                                                                                                               
[26484] "Stage_0_AIDS-Related_Anal_Canal_Cancer"                                                                                                                               
[26485] "Stage_I_AIDS-Related_Anal_Canal_Cancer"                                                                                                                               
[26486] "Stage_II_AIDS-Related_Anal_Canal_Cancer"                                                                                                                              
[26487] "Stage_III_AIDS-Related_Anal_Canal_Cancer"                                                                                                                             
[26488] "Stage_IV_AIDS-Related_Anal_Canal_Cancer"                                                                                                                              
[26489] "Ovarian_Endometrioid_Adenofibroma"                                                                                                                                    
[26490] "Ovarian_Endometrioid_Cystadenofibroma"                                                                                                                                
[26491] "Borderline_Ovarian_Endometrioid_Cystadenofibroma"                                                                                                                     
[26492] "L1_Acute_Lymphoblastic_Leukemia"                                                                                                                                      
[26493] "Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor"                                                                                                           
[26494] "Metastatic_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor"                                                                                                
[26495] "Extraosseous_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor"                                                                                              
[26496] "Localized_Primitive_Neuroectodermal_Tumor"                                                                                                                            
[26497] "Recurrent_Primitive_Neuroectodermal_Tumor"                                                                                                                            
[26498] "Positive_Lymph_Node"                                                                                                                                                  
[26499] "Hormonal_Change"                                                                                                                                                      
[26500] "Ptosis"                                                                                                                                                               
[26501] "Ruptured_Thoracic_Aneurysm"                                                                                                                                           
[26502] "Meckel_s_Diverticulitis"                                                                                                                                              
[26503] "Axonal_Neuropathy"                                                                                                                                                    
[26504] "Xanthogranuloma"                                                                                                                                                      
[26505] "Peritoneal_and_Retroperitoneal_Hemorrhage"                                                                                                                            
[26506] "Congenital_Thyroid_Disorder"                                                                                                                                          
[26507] "Viral_Laryngitis"                                                                                                                                                     
[26508] "Staphylococcal_Septic_Arthritis"                                                                                                                                      
[26509] "Anaplastic_Malignant_Intracranial_Meningioma"                                                                                                                         
[26510] "Stage_I_B-Cell_Non-Hodgkin_s_Lymphoma"                                                                                                                                
[26511] "Ethmoid_Fracture"                                                                                                                                                     
[26512] "Dehydration_Polycythemia"                                                                                                                                             
[26513] "Physiological_Polycythemia"                                                                                                                                           
[26514] "Polycythemia_due_to_Hypoxia"                                                                                                                                          
[26515] "Adult_Dermatomyositis"                                                                                                                                                
[26516] "Mycobacterium_Avium_Complex_Lymphadenitis"                                                                                                                            
[26517] "Mycobacterium_Avium_Intracellulare_Lymphadenitis"                                                                                                                     
[26518] "Permanent_Spinal_Nerve_Paralysis"                                                                                                                                     
[26519] "Conjunctival_Ecchymosis"                                                                                                                                              
[26520] "Dissecting_Thoracic_Aortic_Aneurysm"                                                                                                                                  
[26521] "Transient_Hypogammaglobulinemia"                                                                                                                                      
[26522] "Blennorrhagic_Arthritis"                                                                                                                                              
[26523] "AIDS-Related_Enterocolitis"                                                                                                                                           
[26524] "Periampullary_Adenocarcinoma"                                                                                                                                         
[26525] "Resectable_Duodenal_Carcinoma"                                                                                                                                        
[26526] "Non-Resectable_Cholangiocarcinoma"                                                                                                                                    
[26527] "Recurrent_Cholangiocarcinoma"                                                                                                                                         
[26528] "Resectable_Cholangiocarcinoma"                                                                                                                                        
[26529] "Stage_I_Centroblastic_Follicular_Lymphoma"                                                                                                                            
[26530] "Stage_II_Centroblastic_Follicular_Lymphoma"                                                                                                                           
[26531] "Necrotizing_Gastritis"                                                                                                                                                
[26532] "Injection_Site_Arthritis"                                                                                                                                             
[26533] "Thyroid_Malformation"                                                                                                                                                 
[26534] "Postauricular_Lymphadenitis"                                                                                                                                          
[26535] "Axillary_Lymphadenitis"                                                                                                                                               
[26536] "Adrenal_Gland_Abscess"                                                                                                                                                
[26537] "Glossopharyngeal_Nerve_Paralysis"                                                                                                                                     
[26538] "Lumbar_Vertebral_Fracture_L2"                                                                                                                                         
[26539] "Median_Nerve_Paralysis"                                                                                                                                               
[26540] "Congenital_Neuropathy"                                                                                                                                                
[26541] "Inner_Ear_Infection"                                                                                                                                                  
[26542] "Bacterial_Gastritis"                                                                                                                                                  
[26543] "Herpetic_Gastritis"                                                                                                                                                   
[26544] "Fungal_Gastritis"                                                                                                                                                     
[26545] "Pituitary_Hypoplasia"                                                                                                                                                 
[26546] "AIDS-Related_Retinopathy"                                                                                                                                             
[26547] "Non-Resectable_Hepatocellular_Carcinoma"                                                                                                                              
[26548] "Parathyroid_Gland_Abscess"                                                                                                                                            
[26549] "Tuberculous_Abscess"                                                                                                                                                  
[26550] "Granulomatous_Gastritis"                                                                                                                                              
[26551] "Histiocytic_Sarcoma"                                                                                                                                                  
[26552] "Chronic_Myeloproliferative_Disease_Unclassifiable"                                                                                                                    
[26553] "Immune_System_and_Related_Disorders"                                                                                                                                  
[26554] "Peripheral_T-Cell_Lymphoma_Large_Cell"                                                                                                                                
[26555] "Localized_Peripheral_Primitive_Neuroectodermal_Tumor_of_Bone"                                                                                                         
[26556] "Recurrent_Peripheral_Primitive_Neuroectodermal_Tumor_of_Bone"                                                                                                         
[26557] "Mixed_Pineocytoma-Pineoblastoma"                                                                                                                                      
[26558] "Leukemia_Antiquated"                                                                                                                                                  
[26559] "Refractory_Hematologic_Malignancy"                                                                                                                                    
[26560] "Relapsed_Hematologic_Malignancy"                                                                                                                                      
[26561] "Unresectable_Malignant_Neoplasm"                                                                                                                                      
[26562] "Philadelphia_Chromosome_Negative_BCR-ABL_Positive_Chronic_Myelogenous_Leukemia"                                                                                       
[26563] "Philadelphia_Chromosome_Negative_BCR-ABL_Negative_Chronic_Myelogenous_Leukemia"                                                                                       
[26564] "Childhood_Ganglioglioma"                                                                                                                                              
[26565] "Adult_Ganglioglioma"                                                                                                                                                  
[26566] "Childhood_Yolk_Sac_Tumor"                                                                                                                                             
[26567] "Adult_Primary_Cutaneous_Anaplastic_Large_Cell_Lymphoma"                                                                                                               
[26568] "Adult_Systemic_Anaplastic_Large_Cell_Lymphoma"                                                                                                                        
[26569] "Adult_Anaplastic_Large_Cell_Lymphoma"                                                                                                                                 
[26570] "Childhood_Hepatic_Neoplasm"                                                                                                                                           
[26571] "Adult_Pleomorphic_Rhabdomyosarcoma"                                                                                                                                   
[26572] "Adult_Clear_Cell_Sarcoma_of_Soft_Parts"                                                                                                                               
[26573] "Childhood_Clear_Cell_Sarcoma_of_Soft_Parts"                                                                                                                           
[26574] "Childhood_Desmoplastic_Small_Round_Cell_Tumor"                                                                                                                        
[26575] "Adult_Desmoplastic_Small_Round_Cell_Tumor"                                                                                                                            
[26576] "Childhood_Mesenchymal_Chondrosarcoma"                                                                                                                                 
[26577] "Adult_Mesenchymal_Chondrosarcoma"                                                                                                                                     
[26578] "Childhood_Extraskeletal_Osteosarcoma"                                                                                                                                 
[26579] "Childhood_Myxoid_Chondrosarcoma"                                                                                                                                      
[26580] "Adult_Myxoid_Chondrosarcoma"                                                                                                                                          
[26581] "Mucin-Secreting_Adenocarcinoma"                                                                                                                                       
[26582] "Thyroid_Adenocarcinoma"                                                                                                                                               
[26583] "Metastatic_Carcinoma_to_Adrenal_Cortex"                                                                                                                               
[26584] "Abdominal_Carcinomatosis"                                                                                                                                             
[26585] "Meningeal_Carcinomatosis"                                                                                                                                             
[26586] "Pleural_Carcinomatosis"                                                                                                                                               
[26587] "Pericardial_Carcinomatosis"                                                                                                                                           
[26588] "Lymphoepithelioma-Like_Gastric_Carcinoma"                                                                                                                             
[26589] "Lymphoepithelioma-Like_Carcinoma"                                                                                                                                     
[26590] "Sclerosing_Hepatocellular_Carcinoma"                                                                                                                                  
[26591] "Carcinoma_Arising_in_Nasal_Papillomatosis"                                                                                                                            
[26592] "Ovarian_Small_Cell_Carcinoma"                                                                                                                                         
[26593] "Metastatic_Ovarian_Small_Cell_Carcinoma_with_Hypercalcemia"                                                                                                           
[26594] "Basophil_Adenocarcinoma"                                                                                                                                              
[26595] "Parathyroid_Oncocytic_Adenoma"                                                                                                                                        
[26596] "Vaginal_Melanoma"                                                                                                                                                     
[26597] "Intraosseous_Ameloblastoma"                                                                                                                                           
[26598] "Extraosseous_Ameloblastoma"                                                                                                                                           
[26599] "Follicular_Ameloblastoma"                                                                                                                                             
[26600] "Granular_Cell_Ameloblastoma"                                                                                                                                          
[26601] "Adult_Spinal_Cord_Ependymoma"                                                                                                                                         
[26602] "Adult_Central_Nervous_System_Mature_Teratoma"                                                                                                                         
[26603] "Adult_Central_Nervous_System_Immature_Teratoma"                                                                                                                       
[26604] "Adult_Central_Nervous_System_Mixed_Germ_Cell_Neoplasm"                                                                                                                
[26605] "Childhood_Central_Nervous_System_Mixed_Germ_Cell_Neoplasm"                                                                                                            
[26606] "Childhood_Central_Nervous_System_Mature_Teratoma"                                                                                                                     
[26607] "Childhood_Central_Nervous_System_Immature_Teratoma"                                                                                                                   
[26608] "Childhood_Central_Nervous_System_Germinoma"                                                                                                                           
[26609] "Duodenal_Delta_Cell_Somatostatin_Producing_Neoplasm"                                                                                                                  
[26610] "Metastatic_Carcinoma_to_the_Lung"                                                                                                                                     
[26611] "Small_Intestinal_Burkitt_s_Lymphoma"                                                                                                                                  
[26612] "Small_Intestinal_Atypical_Burkitt_s_Burkitt_s-Like_Lymphoma"                                                                                                          
[26613] "Colon_Mantle_Cell_Lymphoma"                                                                                                                                           
[26614] "Ampulla_of_Vater_Tubulovillous_Adenoma"                                                                                                                               
[26615] "Adenoma_of_the_Colon_with_Intramucosal_Adenocarcinoma"                                                                                                                
[26616] "Ampulla_of_Vater_Clear_Cell_Adenocarcinoma"                                                                                                                           
[26617] "Ampulla_of_Vater_Intestinal_Type_Adenocarcinoma"                                                                                                                      
[26618] "Ampulla_of_Vater_Mucinous_Adenocarcinoma"                                                                                                                             
[26619] "Ampulla_of_Vater_Squamous_Cell_Carcinoma"                                                                                                                             
[26620] "Ampulla_of_Vater_Adenosquamous_Carcinoma"                                                                                                                             
[26621] "Ampulla_of_Vater_Undifferentiated_Carcinoma"                                                                                                                          
[26622] "Esophageal_Verrucous_Carcinoma"                                                                                                                                       
[26623] "Esophageal_Adenosquamous_Carcinoma"                                                                                                                                   
[26624] "Esophageal_Undifferentiated_Carcinoma"                                                                                                                                
[26625] "Esophageal_Squamous_Intraepithelial_Neoplasia"                                                                                                                        
[26626] "Esophageal_Glandular_Intraepithelial_Neoplasia"                                                                                                                       
[26627] "Esophageal_High-Grade_Intraepithelial_Neoplasia"                                                                                                                      
[26628] "Esophageal_High-Grade_Squamous_Intraepithelial_Neoplasia"                                                                                                             
[26629] "Esophageal_Low-Grade_Squamous_Intraepithelial_Neoplasia"                                                                                                              
[26630] "Esophageal_Low-Grade_Glandular_Intraepithelial_Neoplasia"                                                                                                             
[26631] "Esophageal_High-Grade_Glandular_Intraepithelial_Neoplasia"                                                                                                            
[26632] "Esophageal_Gastrointestinal_Stromal_Tumor"                                                                                                                            
[26633] "Low_Risk_Esophageal_Gastrointestinal_Stromal_Tumor"                                                                                                                   
[26634] "High_Risk_Esophageal_Gastrointestinal_Stromal_Tumor"                                                                                                                  
[26635] "Intermediate_Risk_Esophageal_Gastrointestinal_Stromal_Tumor"                                                                                                          
[26636] "Intermediate_Risk_Small_Intestinal_Gastrointestinal_Stromal_Tumor"                                                                                                    
[26637] "Intermediate_Risk_Gastric_Gastrointestinal_Stromal_Tumor"                                                                                                             
[26638] "Low-Grade_Gastric_Intraepithelial_Neoplasia"                                                                                                                          
[26639] "High-Grade_Gastric_Intraepithelial_Neoplasia"                                                                                                                         
[26640] "Benign_Gastric_Mesenchymal_Neoplasm"                                                                                                                                  
[26641] "Malignant_Gastric_Mesenchymal_Neoplasm"                                                                                                                               
[26642] "Gastric_Mantle_Cell_Lymphoma"                                                                                                                                         
[26643] "Small_Intestinal_Mantle_Cell_Lymphoma"                                                                                                                                
[26644] "Gastric_Enterochromaffin-Like_Cell_Carcinoid_Tumor"                                                                                                                   
[26645] "Gastric_EC-Cell_Serotonin_Producing_Carcinoid_Tumor"                                                                                                                  
[26646] "Gastric_G-Cell_Gastrin_Producing_Neoplasm"                                                                                                                            
[26647] "Appendiceal_L-Cell_Glucagon-Like_Peptide_Producing_Neoplasm"                                                                                                          
[26648] "Colonic_EC-Cell_Serotonin_Producing_Tumor"                                                                                                                            
[26649] "Colonic_L-Cell_Glucagon-Like_Peptide_Producing_Neoplasm"                                                                                                              
[26650] "L-Cell_Glucagon-Like_Peptide_Producing_Neoplasm"                                                                                                                      
[26651] "Small_Intestinal_Small_Cell_Carcinoma"                                                                                                                                
[26652] "Small_Intestinal_G-Cell_Gastrin_Producing_Neoplasm"                                                                                                                   
[26653] "Small_Intestinal_EC-Cell_Serotonin_Producing_Tumor"                                                                                                                   
[26654] "Small_Intestinal_L-Cell_Glucagon-Like_Peptide_Producing_Neoplasm"                                                                                                     
[26655] "Small_Intestinal_Delta_Cell_Somatostatin_Producing_Neoplasm"                                                                                                          
[26656] "Pancreatic_Vasoactive_Intestinal_Peptide_Producing_Neoplasm"                                                                                                          
[26657] "Small_Intestinal_Vasoactive_Intestinal_Peptide_Producing_Neoplasm"                                                                                                    
[26658] "Colorectal_Tubular_Adenoma"                                                                                                                                           
[26659] "Colorectal_Adenoma_with_Moderate_Dysplasia"                                                                                                                           
[26660] "Colorectal_Adenoma_with_Mild_Dysplasia"                                                                                                                               
[26661] "Colorectal_Intraepithelial_Neoplasia"                                                                                                                                 
[26662] "Colorectal_Low-Grade_Intraepithelial_Neoplasia"                                                                                                                       
[26663] "Colorectal_High-Grade_Intraepithelial_Neoplasia"                                                                                                                      
[26664] "Small_Intestinal_Intraepithelial_Neoplasia"                                                                                                                           
[26665] "Small_Intestinal_Low-Grade_Intraepithelial_Neoplasia"                                                                                                                 
[26666] "Small_Intestinal_High-Grade_Intraepithelial_Neoplasia"                                                                                                                
[26667] "Colon_Burkitt_s_Lymphoma"                                                                                                                                             
[26668] "Pancreatic_Adrenocorticotropic_Hormone_Producing_Neoplasm"                                                                                                            
[26669] "Stage_0_Lung_Cancer"                                                                                                                                                  
[26670] "Paraproteinemia"                                                                                                                                                      
[26671] "Disseminated_Carcinoma"                                                                                                                                               
[26672] "Disseminated_Malignant_Neoplasm"                                                                                                                                      
[26673] "Peripheral_Neuroectodermal_Tumor_of_Soft_Tissues"                                                                                                                     
[26674] "Proximal-Type_Epithelioid_Sarcoma"                                                                                                                                    
[26675] "Distal-Type_Epithelioid_Sarcoma"                                                                                                                                      
[26676] "Superficial_Bladder_Cancer"                                                                                                                                           
[26677] "Bone_Lipoma"                                                                                                                                                          
[26678] "Benign_Bone_Schwannoma"                                                                                                                                               
[26679] "Benign_Giant_Cell_Tumor_of_Bone"                                                                                                                                      
[26680] "Gingival_Angiofibroma"                                                                                                                                                
[26681] "Nasopharyngeal_Angiofibroma"                                                                                                                                          
[26682] "Myxoid_Rhabdomyoma"                                                                                                                                                   
[26683] "Mesenchymal_Extraskeletal_Chondrosarcoma"                                                                                                                             
[26684] "Secondary_Chondrosarcoma"                                                                                                                                             
[26685] "Lipoblastoma"                                                                                                                                                         
[26686] "Neural_Fibrolipoma"                                                                                                                                                   
[26687] "Hepatic_Angiomyolipoma"                                                                                                                                               
[26688] "Pelvic_Lipomatosis"                                                                                                                                                   
[26689] "Steroid_Lipomatosis"                                                                                                                                                  
[26690] "Mediastinal_Lipomatosis"                                                                                                                                              
[26691] "Spindle_Cell_Liposarcoma"                                                                                                                                             
[26692] "t_11_14_q13_q32"                                                                                                                                                      
[26693] "Congenital_Granular_Cell_Tumor"                                                                                                                                       
[26694] "Conventional_Alveolar_Rhabdomyosarcoma"                                                                                                                               
[26695] "Solid_Alveolar_Rhabdomyosarcoma"                                                                                                                                      
[26696] "Granular_Cell_Leiomyosarcoma"                                                                                                                                         
[26697] "Inflammatory_Leiomyosarcoma"                                                                                                                                          
[26698] "Glomangiomatosis"                                                                                                                                                     
[26699] "Glomus_Tumor_of_Uncertain_Malignant_Potential"                                                                                                                        
[26700] "Infantile_Hemangiopericytoma"                                                                                                                                         
[26701] "Lipomatous_Hemangiopericytoma"                                                                                                                                        
[26702] "Lymphadenopathic_Kaposi_s_Sarcoma"                                                                                                                                    
[26703] "Well-Differentiated_Extraskeletal_Chondrosarcoma"                                                                                                                     
[26704] "Myxoid_Extraskeletal_Chondrosarcoma"                                                                                                                                  
[26705] "Angiomatosis"                                                                                                                                                         
[26706] "Diffuse_Angiomatosis"                                                                                                                                                 
[26707] "Glomeruloid_Hemangioma"                                                                                                                                               
[26708] "Hobnail_Hemangioma"                                                                                                                                                   
[26709] "Hemangioma_of_Peripheral_Nerve"                                                                                                                                       
[26710] "Intra-Abdominal_Lymphangioma"                                                                                                                                         
[26711] "Cutaneous_Lymphangioma"                                                                                                                                               
[26712] "Kaposiform_Hemangioendothelioma"                                                                                                                                      
[26713] "Hobnail_Hemangioendothelioma"                                                                                                                                         
[26714] "Angiosarcoma_Associated_with_Lymphedema"                                                                                                                              
[26715] "Radiation-Related_Angiosarcoma"                                                                                                                                       
[26716] "Adult_Xanthogranuloma"                                                                                                                                                
[26717] "Sclerotic_Fibroma"                                                                                                                                                    
[26718] "Epidermolytic_Acanthoma"                                                                                                                                              
[26719] "Acantholytic_Acanthoma"                                                                                                                                               
[26720] "Large_Cell_Acanthoma"                                                                                                                                                 
[26721] "Epidermolysis_Verruciformis"                                                                                                                                          
[26722] "Benign_Hair_Follicle_Neoplasm"                                                                                                                                        
[26723] "Classic_Type_Trichilemmoma"                                                                                                                                           
[26724] "Desmoplastic_Trichilemmoma"                                                                                                                                           
[26725] "Classic_Type_Trichoepithelioma"                                                                                                                                       
[26726] "Desmoplastic_Trichoepithelioma"                                                                                                                                       
[26727] "Trichoblastic_Fibroma"                                                                                                                                                
[26728] "Trichogenic_Myxoma"                                                                                                                                                   
[26729] "Tubular_Apocrine_Adenoma"                                                                                                                                             
[26730] "Angiokeratoma_Corporis_Diffusum"                                                                                                                                      
[26731] "Malignant_Cutaneous_Vascular_Neoplasm"                                                                                                                                
[26732] "Classic_Type_Lipoma"                                                                                                                                                  
[26733] "Pre-Malignant_Skin_Epithelial_Lesions"                                                                                                                                
[26734] "Malignant_Acrospiroma"                                                                                                                                                
[26735] "Adnexal_Mucinous_Adenocarcinoma"                                                                                                                                      
[26736] "Aggressive_Digital_Papillary_Adenocarcinoma"                                                                                                                          
[26737] "Adenoid_Basal_Cell_Carcinoma"                                                                                                                                         
[26738] "Clear_Cell_Basal_Cell_Carcinoma"                                                                                                                                      
[26739] "Cystic_Basal_Cell_Carcinoma"                                                                                                                                          
[26740] "Follicular_Pilar_Basal_Cell_Carcinoma"                                                                                                                                
[26741] "Infiltrating_Basal_Cell_Carcinoma"                                                                                                                                    
[26742] "Infundibulocystic_Basal_Cell_Carcinoma"                                                                                                                               
[26743] "Micronodular_Basal_Cell_Carcinoma"                                                                                                                                    
[26744] "Skin_Pseudovascular_Squamous_Cell_Carcinoma"                                                                                                                          
[26745] "Skin_Basaloid_Squamous_Cell_Carcinoma"                                                                                                                                
[26746] "Retiform_Hemangioendothelioma"                                                                                                                                        
[26747] "Classic_Type_Atypical_Fibroxanthoma"                                                                                                                                  
[26748] "Spindle_Cell_Type_Atypical_Fibroxanthoma"                                                                                                                             
[26749] "Fibrosarcomatous_Dermatofibrosarcoma_Protuberans"                                                                                                                     
[26750] "Melanoacanthoma"                                                                                                                                                      
[26751] "Reactive_Cutaneous_Fibrous_Lesions"                                                                                                                                   
[26752] "Non-Neoplastic_Gastrointestinal_Disorder"                                                                                                                             
[26753] "Disorder_by_Site"                                                                                                                                                     
[26754] "Multiple_Lobular_Capillary_Hemangiomas"                                                                                                                               
[26755] "Genital_Human_Papilloma_Virus_Infection"                                                                                                                              
[26756] "Dermatosis"                                                                                                                                                           
[26757] "Non-Neoplastic_Skin_Disorder"                                                                                                                                         
[26758] "Non-Neoplastic_Skin_Cyst"                                                                                                                                             
[26759] "Non-Neoplastic_Lung_Disorder"                                                                                                                                         
[26760] "Lymphocytic_Interstitial_Pneumonitis"                                                                                                                                 
[26761] "Mixed_Mineral_Dust_Pneumoconiosis"                                                                                                                                    
[26762] "Neonatal_Respiratory_Distress_Syndrome"                                                                                                                               
[26763] "Respiratory_Distress_Syndrome"                                                                                                                                        
[26764] "Hyaline_Membrane_Syndrome"                                                                                                                                            
[26765] "Non-Neoplastic_Pleural_Disorder"                                                                                                                                      
[26766] "Endocrine_Syndrome"                                                                                                                                                   
[26767] "Non-Neoplastic_Endocrine_Disorder"                                                                                                                                    
[26768] "Non-Neoplastic_Thyroid_Gland_Disorder"                                                                                                                                
[26769] "Non-Neoplastic_Pituitary_Gland_Disorder"                                                                                                                              
[26770] "Non-Neoplastic_Parathyroid_Gland_Disorder"                                                                                                                            
[26771] "Non-Neoplastic_Adrenal_Gland_Disorder"                                                                                                                                
[26772] "Non-Neoplastic_Gonadal_Disorder"                                                                                                                                      
[26773] "Head_and_Neck_Disorder"                                                                                                                                               
[26774] "Non-Neoplastic_Bone_Disorder"                                                                                                                                         
[26775] "Non-Neoplastic_Soft_Tissue_Disorder"                                                                                                                                  
[26776] "Connective_and_Soft_Tissue_Disorder"                                                                                                                                  
[26777] "Idiopathic_Granulomatous_Myositis"                                                                                                                                    
[26778] "Childhood_Dermatomyositis"                                                                                                                                            
[26779] "Osteomyelitis"                                                                                                                                                        
[26780] "Myositis"                                                                                                                                                             
[26781] "Hyperimmunoglobulin_Syndrome"                                                                                                                                         
[26782] "Peripheral_Nervous_System_Disorder"                                                                                                                                   
[26783] "Meningeal_Fibrosis"                                                                                                                                                   
[26784] "Central_Nervous_System_Infectious_Disorder"                                                                                                                           
[26785] "Infectious_Disorder_by_Site"                                                                                                                                          
[26786] "HIV_Leukoencephalopathy"                                                                                                                                              
[26787] "Spongiform_Encephalopathy"                                                                                                                                            
[26788] "Non-Neoplastic_Central_Nervous_System_Disorder"                                                                                                                       
[26789] "Non-Neoplastic_Peripheral_Nervous_System_Disorder"                                                                                                                    
[26790] "Non-Neoplastic_Nervous_System_Disorder"                                                                                                                               
[26791] "Peripheral_Nervous_System_Infectious_Disorder"                                                                                                                        
[26792] "Nervous_System_Infectious_Disorder"                                                                                                                                   
[26793] "Vagus_Nerve_Disorder"                                                                                                                                                 
[26794] "Abducent_Nerve_Paralysis"                                                                                                                                             
[26795] "Abducens_Nerve_Disorder"                                                                                                                                              
[26796] "Facial_Nerve_Disorder"                                                                                                                                                
[26797] "Femoral_Neuropathy"                                                                                                                                                   
[26798] "Peroneal_Neuropathy"                                                                                                                                                  
[26799] "Oculomotor_Nerve_Paralysis"                                                                                                                                           
[26800] "Oculomotor_Nerve_Disorder"                                                                                                                                            
[26801] "Non-Neoplastic_Urinary_Tract_Disorder"                                                                                                                                
[26802] "Non-Neoplastic_Renal_Disorder"                                                                                                                                        
[26803] "Non-Neoplastic_Bladder_Disorder"                                                                                                                                      
[26804] "Non-Neoplastic_Urethra_Disorder"                                                                                                                                      
[26805] "Non-Neoplastic_Ureter_Disorder"                                                                                                                                       
[26806] "Non-Neoplastic_Eye_Disorder"                                                                                                                                          
[26807] "Conjunctival_Disorder"                                                                                                                                                
[26808] "Conjuctivitis"                                                                                                                                                        
[26809] "Non-Neoplastic_Conjunctival_Disorder"                                                                                                                                 
[26810] "Non-Neoplastic_Corneal_Disorder"                                                                                                                                      
[26811] "Non-Neoplastic_Eyelid_Disorder"                                                                                                                                       
[26812] "Non-Neoplastic_Retinal_Disorder"                                                                                                                                      
[26813] "Male_Non-Neoplastic_Reproductive_System_Disorder"                                                                                                                     
[26814] "Female_Non-Neoplastic_Reproductive_System_Disorder"                                                                                                                   
[26815] "Non-Neoplastic_Reproductive_System_Disorder"                                                                                                                          
[26816] "Prostate_Non-Neoplastic_Disorder"                                                                                                                                     
[26817] "Prostatic_Infection"                                                                                                                                                  
[26818] "Testicular_Non-Neoplastic_Disorder"                                                                                                                                   
[26819] "Testicular_Infarction"                                                                                                                                                
[26820] "Penile_Non-Neoplastic_Disorder"                                                                                                                                       
[26821] "Placental_Non-Neoplastic_Disorder"                                                                                                                                    
[26822] "Vulvar_Non-Neoplastic_Disorder"                                                                                                                                       
[26823] "Vaginal_Non-Neoplastic_Disorder"                                                                                                                                      
[26824] "Cervical_Non-Neoplastic_Disorder"                                                                                                                                     
[26825] "Cervical_Endometriosis"                                                                                                                                               
[26826] "Uterine_Corpus_Non-Neoplastic_Disorder"                                                                                                                               
[26827] "Non_Specific_Chronic_Endometritis"                                                                                                                                    
[26828] "Granulomatous_Endometritis"                                                                                                                                           
[26829] "Ovarian_Non-Neoplastic_Disorder"                                                                                                                                      
[26830] "Ovarian_Endometriosis"                                                                                                                                                
[26831] "Uterine_Non-Neoplastic_Disorder"                                                                                                                                      
[26832] "Fallopian_Tube_Non-Neoplastic_Disorder"                                                                                                                               
[26833] "Vulvar_Disorder"                                                                                                                                                      
[26834] "Transplant-Related_Malignant_Neoplasm"                                                                                                                                
[26835] "Transplant-Related_Carcinoma"                                                                                                                                         
[26836] "Transplant-Related_Urothelial_Transitional_Cell_Carcinoma"                                                                                                            
[26837] "Transplant-Related_Hepatocellular_Carcinoma"                                                                                                                          
[26838] "Transplant-Related_Skin_Squamous_Cell_Carcinoma"                                                                                                                      
[26839] "Transplant-Related_Lung_Carcinoma"                                                                                                                                    
[26840] "Transplant-Related_Renal_Cell_Carcinoma"                                                                                                                              
[26841] "Transplant-Related_Hematologic_Malignancy"                                                                                                                            
[26842] "Transplant-Related_Kaposi_s_Sarcoma"                                                                                                                                  
[26843] "Oral_Cavity_Disorder"                                                                                                                                                 
[26844] "Head_and_Neck_Precancerous_Condition"                                                                                                                                 
[26845] "Partial_Hearing_Loss"                                                                                                                                                 
[26846] "Deafness"                                                                                                                                                             
[26847] "Conductive_Hearing_Loss"                                                                                                                                              
[26848] "Conductive_Deafness"                                                                                                                                                  
[26849] "Nasal_Cavity_and_Paranasal_Sinus_Disorder"                                                                                                                            
[26850] "Neck_Disorder"                                                                                                                                                        
[26851] "Salivary_Cyst"                                                                                                                                                        
[26852] "Non-Neoplastic_Oral_Disorder"                                                                                                                                         
[26853] "Non-Neoplastic_Oral_Cavity_Disorder"                                                                                                                                  
[26854] "Non-Neoplastic_Ear_Disorder"                                                                                                                                          
[26855] "Non-Neoplastic_External_Ear_Disorder"                                                                                                                                 
[26856] "Non-Neoplastic_Inner_Ear_Disorder"                                                                                                                                    
[26857] "Skull_Disorder"                                                                                                                                                       
[26858] "Non-Neoplastic_Nasal_Cavity_and_Paranasal_Sinus_Disorder"                                                                                                             
[26859] "Non-Neoplastic_Paranasal_Sinus_Disorder"                                                                                                                              
[26860] "Non-Neoplastic_Nasal_Cavity_Disorder"                                                                                                                                 
[26861] "Non-Neoplastic_Laryngeal_Disorder"                                                                                                                                    
[26862] "Non-Neoplastic_Neck_Disorder"                                                                                                                                         
[26863] "Non-Neoplastic_Pharyngeal_Disorder"                                                                                                                                   
[26864] "Non-Neoplastic_Salivary_Gland_Disorder"                                                                                                                               
[26865] "Non-Neoplastic_Head_and_Neck_Disorder"                                                                                                                                
[26866] "Peritoneal_and_Retroperitoneal_Disorder"                                                                                                                              
[26867] "Non-Neoplastic_Peritoneal_and_Retroperitoneal_Disorder"                                                                                                               
[26868] "Non-Neoplastic_Peritoneal_Disorder"                                                                                                                                   
[26869] "Retroperitoneal_Disorder"                                                                                                                                             
[26870] "Non-Neoplastic_Retroperitoneal_Disorder"                                                                                                                              
[26871] "Respiratory_and_Thoracic_Disorder"                                                                                                                                    
[26872] "Non-Neoplastic_Respiratory_Thoracic_and_Mediastinal_Disorder"                                                                                                         
[26873] "Non-Neoplastic_Mediastinal_Disorder"                                                                                                                                  
[26874] "Non-Neoplastic_Cardiovascular_Disorder"                                                                                                                               
[26875] "Virus-Related_Malignant_Neoplasm"                                                                                                                                     
[26876] "Human_Papilloma_Virus-Related_Carcinoma"                                                                                                                              
[26877] "Human_Papilloma_Virus-Related_Cervical_Carcinoma"                                                                                                                     
[26878] "Human_Papilloma_Virus-Related_Cervical_Squamous_Cell_Carcinoma"                                                                                                       
[26879] "Human_Papilloma_Virus-Related_Endocervical_Adenocarcinoma"                                                                                                            
[26880] "Human_Papilloma_Virus-Related_Verrucous_Carcinoma"                                                                                                                    
[26881] "Human_Papilloma_Virus-Related_Vulvar_Squamous_Cell_Carcinoma"                                                                                                         
[26882] "Human_Papilloma_Virus-Related_Esophageal_Squamous_Cell_Carcinoma"                                                                                                     
[26883] "Human_Papilloma_Virus-Related_Anal_Squamous_Cell_Carcinoma"                                                                                                           
[26884] "Human_Papilloma_Virus-Related_Penile_Squamous_Cell_Carcinoma"                                                                                                         
[26885] "Human_Papilloma_Virus-Related_Squamous_Cell_Carcinoma"                                                                                                                
[26886] "Human_Papilloma_Virus-Related_Adenocarcinoma"                                                                                                                         
[26887] "HTLV-1-Related_Malignant_Neoplasm"                                                                                                                                    
[26888] "Hepatitis_Virus-Related_Hepatocellular_Carcinoma"                                                                                                                     
[26889] "Hepatitis_B_Virus-Related_Hepatocellular_Carcinoma"                                                                                                                   
[26890] "Hepatitis_C_Virus-Related_Hepatocellular_Carcinoma"                                                                                                                   
[26891] "Epstein-Barr_Virus-Related_Malignant_Neoplasm"                                                                                                                        
[26892] "Epstein-Barr_Virus-Related_Carcinoma"                                                                                                                                 
[26893] "Epstein-Barr_Virus-Related_Lymphoma"                                                                                                                                  
[26894] "Epstein-Barr_Virus-Related_Hodgkin_s_Lymphoma"                                                                                                                        
[26895] "Epstein-Barr_Virus-Related_Non-Hodgkin_s_Lymphoma"                                                                                                                    
[26896] "Epstein-Barr_Virus-Related_Burkitt_s_Lymphoma"                                                                                                                        
[26897] "Epstein-Barr_Virus-Related_Clonal_Post-Transplant_Lymphoproliferative_Disorder"                                                                                       
[26898] "Epstein-Barr_Virus-Related_Post-Transplant_Lymphoproliferative_Disorder"                                                                                              
[26899] "Human_Herpes_Virus_8-Related_Malignant_Neoplasm"                                                                                                                      
[26900] "Virus-Related_Carcinoma"                                                                                                                                              
[26901] "Virus-Related_Lymphoma"                                                                                                                                               
[26902] "AIDS-Related_Carcinoma"                                                                                                                                               
[26903] "Secondary_Myelofibrosis"                                                                                                                                              
[26904] "Previously_Treated_Myelodysplastic_Syndrome"                                                                                                                          
[26905] "C-Myc_Translocation"                                                                                                                                                  
[26906] "t_8_14"                                                                                                                                                               
[26907] "t_2_8"                                                                                                                                                                
[26908] "t_8_22"                                                                                                                                                               
[26909] "Virus-Related_Sarcoma"                                                                                                                                                
[26910] "Psammoma_Body_Formation"                                                                                                                                              
[26911] "Pulmonary_Sulcus_Neoplasm"                                                                                                                                            
[26912] "t_2_5"                                                                                                                                                                
[26913] "_5q-"                                                                                                                                                                 
[26914] "t_11_18_q21_q21"                                                                                                                                                      
[26915] "CCND1_Gene_Rearrangement"                                                                                                                                             
[26916] "t_1_19_q23_p13_3_PBX_E2A"                                                                                                                                             
[26917] "Extragastrointestinal_Gastrointestinal_Stromal_Tumor"                                                                                                                 
[26918] "Tubulolobular_Breast_Carcinoma"                                                                                                                                       
[26919] "Human_Papilloma_Virus-Related_Malignant_Neoplasm"                                                                                                                     
[26920] "Cutaneous_Radiation-Related_Angiosarcoma"                                                                                                                             
[26921] "Well-Differentiated_Pancreatic_Endocrine_Neoplasm"                                                                                                                    
[26922] "Gastrointestinal_Neuroendocrine_Neoplasm"                                                                                                                             
[26923] "Therapy-Related_Myelodysplastic_Syndrome"                                                                                                                             
[26924] "Vulvar_Lichen_Sclerosus"                                                                                                                                              
[26925] "Psoriasiform_Dermatitis"                                                                                                                                              
[26926] "Porphyria_Cutanea_Tarda"                                                                                                                                              
[26927] "Refractory_Cytopenia_with_Multilineage_Dysplasia_and_Ringed_Sideroblasts"                                                                                             
[26928] "Non-Functioning_Pancreatic_Endocrine_Neoplasm"                                                                                                                        
[26929] "Poorly_Differentiated_Pancreatic_Endocrine_Carcinoma"                                                                                                                 
[26930] "Atypical_Follicular_Adenoma"                                                                                                                                          
[26931] "Childhood_Wilms_Tumor"                                                                                                                                                
[26932] "Very_Low_Risk_Gastrointestinal_Stromal_Tumor"                                                                                                                         
[26933] "Very_Low_Risk_Esophageal_Gastrointestinal_Stromal_Tumor"                                                                                                              
[26934] "Very_Low_Risk_Gastric_Gastrointestinal_Stromal_Tumor"                                                                                                                 
[26935] "Very_Low_Risk_Small_Intestinal_Gastrointestinal_Stromal_Tumor"                                                                                                        
[26936] "Colorectal_Gastrointestinal_Stromal_Tumor"                                                                                                                            
[26937] "Very_Low_Risk_Colorectal_Gastrointestinal_Stromal_Tumor"                                                                                                              
[26938] "Low_Risk_Colorectal_Gastrointestinal_Stromal_Tumor"                                                                                                                   
[26939] "Intermediate_Risk_Colorectal_Gastrointestinal_Stromal_Tumor"                                                                                                          
[26940] "High_Risk_Colorectal_Gastrointestinal_Stromal_Tumor"                                                                                                                  
[26941] "Focal_Active_Colitis"                                                                                                                                                 
[26942] "Thrombohemorrhagic_Event"                                                                                                                                             
[26943] "Stage_IIB_Melanoma_of_the_Skin"                                                                                                                                       
[26944] "Somnolence_Syndrome"                                                                                                                                                  
[26945] "Plexopathy"                                                                                                                                                           
[26946] "Non-Small_Cell_Adenocarcinoma"                                                                                                                                        
[26947] "Hypoxic"                                                                                                                                                              
[26948] "Impotent"                                                                                                                                                             
[26949] "t_9_14_p13_q32"                                                                                                                                                       
[26950] "Precancerous_Dermatitis"                                                                                                                                              
[26951] "Spinal_Degenerative_Disorder"                                                                                                                                         
[26952] "t_1_14_p22_q32"                                                                                                                                                       
[26953] "t_2_18_p12_q21"                                                                                                                                                       
[26954] "Acute_Myeloid_Leukemia_not_Otherwise_Categorized"                                                                                                                     
[26955] "Alkylating_Agent-Related_Acute_Myeloid_Leukemia"                                                                                                                      
[26956] "Topoisomerase_II_Inhibitor-Related_Acute_Myeloid_Leukemia"                                                                                                            
[26957] "Typical_Acute_Promyelocytic_Leukemia"                                                                                                                                 
[26958] "Microgranular_Acute_Promyelocytic_Leukemia"                                                                                                                           
[26959] "t_15_17_q22_q12"                                                                                                                                                      
[26960] "t_16_16_p13_q22"                                                                                                                                                      
[26961] "Bacterium-Related_Malignant_Neoplasm"                                                                                                                                 
[26962] "Helicobacter_Pylori-Related_Malignant_Neoplasm"                                                                                                                       
[26963] "Helicobacter_Pylori-Related_Non-Hodgkin_s_Lymphoma"                                                                                                                   
[26964] "Helicobacter_Pylori-Related_Gastric_Mucosa-Associated_Lymphoid_Tissue_Lymphoma"                                                                                       
[26965] "Helicobacter_Pylori-Related_Carcinoma"                                                                                                                                
[26966] "Helicobacter_Pylori-Related_Gastric_Adenocarcinoma"                                                                                                                   
[26967] "Parasite-Related_Malignant_Neoplasm"                                                                                                                                  
[26968] "Parasite-Related_Carcinoma"                                                                                                                                           
[26969] "Schistosoma_Hematobium-Related_Bladder_Squamous_Cell_Carcinoma"                                                                                                       
[26970] "Opisthorchis_Viverrini-Related_Cholangiocarcinoma"                                                                                                                    
[26971] "Immunodeficiency-Related_Malignant_Neoplasm"                                                                                                                          
[26972] "Old_Burn_Scar-Related_Neoplasm"                                                                                                                                       
[26973] "Cigarette_Smoking-Related_Carcinoma"                                                                                                                                  
[26974] "Tobacco_Chewing-Related_Carcinoma"                                                                                                                                    
[26975] "Asbestos-Related_Malignant_Neoplasm"                                                                                                                                  
[26976] "Aromatic_Dyes-Related_Malignant_Neoplasm"                                                                                                                             
[26977] "Solar_Radiation-Related_Malignant_Neoplasm"                                                                                                                           
[26978] "Giant_Hemangioma"                                                                                                                                                     
[26979] "Autoimmune_Hepatitis_with_Centrilobular_Necrosis"                                                                                                                     
[26980] "Lymphohistiocytoid_Mesothelioma"                                                                                                                                      
[26981] "Myelodysplastic_Myeloproliferative_Disease_Unclassifiable"                                                                                                            
[26982] "Myxoid_Round_Cell_Liposarcoma"                                                                                                                                        
[26983] "Upper_Extremity_Fracture"                                                                                                                                             
[26984] "Arm_Fracture"                                                                                                                                                         
[26985] "Metastatic_Penile_Cancer"                                                                                                                                             
[26986] "Stage_I_Testicular_Non-Seminomatous_Germ_Cell_Tumor"                                                                                                                  
[26987] "Stage_II_Testicular_Non-Seminomatous_Germ_Cell_Tumor"                                                                                                                 
[26988] "Stage_III_Testicular_Non-Seminomatous_Germ_Cell_Tumor"                                                                                                                
[26989] "Female_Reproductive_System_Precancerous_Condition"                                                                                                                    
[26990] "Endometrial_Intraepithelial_Neoplasia"                                                                                                                                
[26991] "Penile_Carcinoma_in_situ"                                                                                                                                             
[26992] "Non-Invasive_Verrucous_Carcinoma_of_the_Penis"                                                                                                                        
[26993] "Spindle_Cell_Type_Gastrointestinal_Stromal_Tumor"                                                                                                                     
[26994] "Mixed_Cell_Type_Gastrointestinal_Stromal_Tumor"                                                                                                                       
[26995] "Polycythemia_Excluding_Polycythemia_Vera"                                                                                                                             
[26996] "Urothelial_Transitional_Cell_Carcinoma_with_Glandular_Differentiation"                                                                                                
[26997] "Urothelial_Transitional_Cell_Carcinoma_with_Squamous_Differentiation"                                                                                                 
[26998] "Common_Acute_Lymphoblastic_Leukemia"                                                                                                                                  
[26999] "Pre-B_Acute_Lymphoblastic_Leukemia"                                                                                                                                   
[27000] "Pre-Pre-B_Acute_Lymphoblastic_Leukemia"                                                                                                                               
[27001] "Mycosis_Fungoides_Working_Formulation"                                                                                                                                
[27002] "Non-Neoplastic_Thymus_Disorder"                                                                                                                                       
[27003] "Thymic_Dysplasia"                                                                                                                                                     
[27004] "Acute_Thymic_Involution"                                                                                                                                              
[27005] "Ectopic_Thymus"                                                                                                                                                       
[27006] "True_Thymic_Hyperplasia"                                                                                                                                              
[27007] "Metastatic_Renal_Cell_Cancer"                                                                                                                                         
[27008] "Hodgkin_s_Disease_Nodular_Sclerosis_Syncytial_Variant"                                                                                                                
[27009] "Hodgkin_s_Disease_Nodular_Sclerosis_Lymphocyte_Depletion"                                                                                                             
[27010] "Hodgkin_s_Lymphoma_Antiquated"                                                                                                                                        
[27011] "Malignant_Non-Hodgkin_s_Lymphoma_Cleaved_Cell"                                                                                                                        
[27012] "Malignant_Non-Hodgkin_s_Lymphoma_Small_Cleaved_Cell"                                                                                                                  
[27013] "Hematopoietic_Neoplasm_of_Unclear_Meaning"                                                                                                                            
[27014] "Bile_Duct_Adenocarcinoma"                                                                                                                                             
[27015] "Bile_Duct_Carcinoma"                                                                                                                                                  
[27016] "Malignant_Endometrial_Neoplasm"                                                                                                                                       
[27017] "Pigmented_Nevus"                                                                                                                                                      
[27018] "Paget_s_Disease_of_Penis"                                                                                                                                             
[27019] "Metastatic_Neoplasm_of_the_Ureter"                                                                                                                                    
[27020] "Metastatic_Neoplasm_of_the_Urethra"                                                                                                                                   
[27021] "Mature_T-ALL"                                                                                                                                                         
[27022] "Malignant_Lymphoma_Convoluted"                                                                                                                                        
[27023] "Diffuse_Malignant_Lymphoma"                                                                                                                                           
[27024] "Malignant_Lymphoma_Large_Cell_Type"                                                                                                                                   
[27025] "Reticulosarcoma"                                                                                                                                                      
[27026] "Mucin-Secreting_Carcinoma"                                                                                                                                            
[27027] "AIDS-Related_Lymphoma_by_Working_Formulation"                                                                                                                         
[27028] "Malignant_Lymphoma_by_Cell_Type_Working_Formulation"                                                                                                                  
[27029] "Stage_IIIC_Breast_Cancer"                                                                                                                                             
[27030] "Invasive_Breast_Carcinoma_by_Histologic_Grade"                                                                                                                        
[27031] "Grade_1_Invasive_Breast_Carcinoma"                                                                                                                                    
[27032] "Grade_2_Invasive_Breast_Carcinoma"                                                                                                                                    
[27033] "Grade_3_Invasive_Breast_Carcinoma"                                                                                                                                    
[27034] "Dysplasia_in_Barrett_s_Esophagus"                                                                                                                                     
[27035] "Low-Grade_Dysplasia_in_Barrett_s_Esophagus"                                                                                                                           
[27036] "High-Grade_Dysplasia_in_Barrett_s_Esophagus"                                                                                                                          
[27037] "Persistent_Superficial_Gastritis"                                                                                                                                     
[27038] "Gastritis_Associated_with_Crohn_s_Disease"                                                                                                                            
[27039] "Uterine_Serous_Carcinoma"                                                                                                                                             
[27040] "Uterine_Corpus_Endometrioid_Adenocarcinoma_Secretory_Variant"                                                                                                         
[27041] "Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Papillae"                                                                                                             
[27042] "Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Small_Glands_Tubules_or_Cords"                                                                                        
[27043] "Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Metaplastic_Changes"                                                                                                  
[27044] "Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Clear_Cell_Change"                                                                                                    
[27045] "Uterine_Corpus_Endometrioid_Adenocarcinoma_with_a_Poorly_Differentiated_Carcinomatous_Component"                                                                      
[27046] "Uterine_Corpus_Endometrioid_Adenocarcinoma_with_an_Undifferentiated_Carcinomatous_Component"                                                                          
[27047] "Villoglandular_Uterine_Corpus_Endometrioid_Adenocarcinoma"                                                                                                            
[27048] "Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Small_Nonvillous_Papillae"                                                                                            
[27049] "Uterine_Corpus_Endometrioid_Adenocarcinoma_Ciliated_Variant"                                                                                                          
[27050] "Oxyphilic_Uterine_Corpus_Endometrioid_Adenocarcinoma"                                                                                                                 
[27051] "Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Spindled_Epithelial_Cells"                                                                                            
[27052] "Human_Papilloma_Virus_Infection"                                                                                                                                      
[27053] "AIDS-Related_Human_Papilloma_Virus_Infection"                                                                                                                         
[27054] "Angiofollicular_Lymphoid_Hyperplasia_Hyaline-Vascular_Type"                                                                                                           
[27055] "Angiofollicular_Lymphoid_Hyperplasia_Plasma_Cell_Type"                                                                                                                
[27056] "Multicentric_Angiofollicular_Lymphoid_Hyperplasia"                                                                                                                    
[27057] "Kaposi_s_Sarcoma-Associated_Human_Herpes_Virus_8_Positive_Extracavity_Lymphoma"                                                                                       
[27058] "V-ABL_Gene"                                                                                                                                                           
[27059] "AIDS-Related_Kaposi_s_Sarcoma-Associated_Human_Herpes_Virus_8_Positive_Extracavity_Lymphoma"                                                                          
[27060] "AIDS-Related_Plasmablastic_Lymphoma"                                                                                                                                  
[27061] "AIDS-Related_Vulvovaginal_Candidiasis"                                                                                                                                
[27062] "AIDS-Related_Cryptococcosis"                                                                                                                                          
[27063] "AIDS-Related_Herpes_Zoster"                                                                                                                                           
[27064] "AIDS-Related_Pneumocystis_Carinii_Pneumonia"                                                                                                                          
[27065] "Parasitic_Infection"                                                                                                                                                  
[27066] "AIDS-Related_Toxoplasmosis"                                                                                                                                           
[27067] "AIDS-Related_Pelvic_Inflammatory_Disease"                                                                                                                             
[27068] "AIDS-Related_Oropharyngeal_Candidiasis"                                                                                                                               
[27069] "AIDS-Related_Isosporiasis"                                                                                                                                            
[27070] "AIDS-Related_Idiopathic_Thrombocytopenic_Purpura"                                                                                                                     
[27071] "Selective_Immunoglobulin_Isotype_Deficiency"                                                                                                                          
[27072] "Congenital_Combined_Immunodeficiency"                                                                                                                                 
[27073] "Congenital_T-Cell_Immunodeficiency"                                                                                                                                   
[27074] "Congenital_Disorder_of_Natural_Immunity"                                                                                                                              
[27075] "Leukocyte_Adhesion_Deficiency"                                                                                                                                        
[27076] "Low-Grade_Papillary_Urothelial_Carcinoma"                                                                                                                             
[27077] "High-Grade_Papillary_Urothelial_Carcinoma"                                                                                                                            
[27078] "Urothelial_Hyperplasia"                                                                                                                                               
[27079] "Flat_Urothelial_Hyperplasia"                                                                                                                                          
[27080] "Papillary_Urothelial_Hyperplasia"                                                                                                                                     
[27081] "Intraurothelial_Neoplasia"                                                                                                                                            
[27082] "Transitional_Cell_Intraepithelial_Neoplasia"                                                                                                                          
[27083] "Low-Grade_Intraurothelial_Neoplasia"                                                                                                                                  
[27084] "Papillary_Urothelial_Neoplasm"                                                                                                                                        
[27085] "Papillary_Urothelial_Neoplasm_of_Low_Malignant_Potential"                                                                                                             
[27086] "Invasive_Urothelial_Transitional_Cell_Carcinoma"                                                                                                                      
[27087] "Type_1_Papillary_Renal_Cell_Carcinoma"                                                                                                                                
[27088] "Type_2_Papillary_Renal_Cell_Carcinoma"                                                                                                                                
[27089] "Classic_Variant_of_Chromophobe_Renal_Cell_Carcinoma"                                                                                                                  
[27090] "Eosinophilic_Variant_of_Chromophobe_Renal_Cell_Carcinoma"                                                                                                             
[27091] "Sporadic_Papillary_Renal_Cell_Carcinoma"                                                                                                                              
[27092] "Xp11_Translocation-Related_Renal_Cell_Carcinoma"                                                                                                                      
[27093] "Unclassified_Renal_Cell_Carcinoma"                                                                                                                                    
[27094] "Sarcomatoid_Renal_Cell_Carcinoma"                                                                                                                                     
[27095] "Carotenosis_Cutis"                                                                                                                                                    
[27096] "Laboratory_and_Clinical_Finding"                                                                                                                                      
[27097] "Multicentric_Reticulohistiocytosis"                                                                                                                                   
[27098] "T-Cell_Proliferation_of_Uncertain_Malignant_Potential"                                                                                                                
[27099] "Recurrent_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor"                                                                                                 
[27100] "Recurrent_Peripheral_Primitive_Neuroectodermal_Tumor"                                                                                                                 
[27101] "Recurrent_Askin_s_Tumor"                                                                                                                                              
[27102] "Localized_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor"                                                                                                 
[27103] "Localized_Askin_s_Tumor"                                                                                                                                              
[27104] "Localized_Peripheral_Primitive_Neuroectodermal_Tumor"                                                                                                                 
[27105] "Retroperitoneal_Leiomyosarcoma"                                                                                                                                       
[27106] "Well_Differentiated_Prostate_Adenocarcinoma"                                                                                                                          
[27107] "Moderately_Differentiated_Prostate_Adenocarcinoma"                                                                                                                    
[27108] "B-Cell_Lymphocytic_Neoplasm"                                                                                                                                          
[27109] "T-Cell_and_NK-Cell_Neoplasm"                                                                                                                                          
[27110] "Mature_T-Cell_and_NK-Cell_Neoplasm"                                                                                                                                   
[27111] "Mature_B-Cell_Lymphocytic_Neoplasm"                                                                                                                                   
[27112] "Chronic_Lymphocytic_Leukemia_Small_Lymphocytic_Lymphoma"                                                                                                              
[27113] "Therapy-Related_Acute_Myeloid_Leukemia_and_Myelodysplastic_Syndrome"                                                                                                  
[27114] "Alkylating_Agent-Related_Acute_Myeloid_Leukemia_and_Myelodysplastic_Syndrome"                                                                                         
[27115] "Sporadic_Burkitt_s_Lymphoma"                                                                                                                                          
[27116] "Immunodeficiency-Related_Burkitt_s_Lymphoma"                                                                                                                          
[27117] "Poorly_Differentiated_Prostate_Adenocarcinoma"                                                                                                                        
[27118] "Lymphocytic_and_Plasma_Cell_Neoplasm"                                                                                                                                 
[27119] "Old_Burn_Scar-Related_Skin_Squamous_Cell_Carcinoma"                                                                                                                   
[27120] "Old_Burn_Scar-Related_Melanoma_of_the_Skin"                                                                                                                           
[27121] "Solar_Radiation-Related_Melanoma_of_the_Skin"                                                                                                                         
[27122] "Solar_Radiation-Related_Skin_Squamous_Cell_Carcinoma"                                                                                                                 
[27123] "Aflatoxins-Related_Hepatocellular_Carcinoma"                                                                                                                          
[27124] "Lifestyle-Related_Neoplasm"                                                                                                                                           
[27125] "Alcohol-Related_Hepatocellular_Carcinoma"                                                                                                                             
[27126] "Asbestos-Related_Lung_Carcinoma"                                                                                                                                      
[27127] "Asbestos-Related_Malignant_Mesothelioma"                                                                                                                              
[27128] "Alcohol-Related_Carcinoma"                                                                                                                                            
[27129] "Alcohol-Related_Esophageal_Carcinoma"                                                                                                                                 
[27130] "Alcohol-Related_Laryngeal_Carcinoma"                                                                                                                                  
[27131] "Ionizing_Radiation-Related_Malignant_Neoplasm"                                                                                                                        
[27132] "Benzene-Related_Acute_Myeloid_Leukemia"                                                                                                                               
[27133] "Radiation-Induced_Pneumonitis"                                                                                                                                        
[27134] "Neoplasm_by_Cause"                                                                                                                                                    
[27135] "Radiation-Related_Disorder"                                                                                                                                           
[27136] "Occupational_Neoplasm"                                                                                                                                                
[27137] "Immunodeficiency-Related_Neoplasm"                                                                                                                                    
[27138] "Papillary_Thymic_Carcinoma"                                                                                                                                           
[27139] "Combined_Thymoma"                                                                                                                                                     
[27140] "Lobular_Neoplasia"                                                                                                                                                    
[27141] "Gastrointestinal_Autonomic_Nerve_Tumor"                                                                                                                               
[27142] "Usual_Ductal_Breast_Hyperplasia"                                                                                                                                      
[27143] "Mammary_Intraepithelial_Neoplasia_Ductal_Type"                                                                                                                        
[27144] "Solitary_Intraductal_Breast_Papilloma"                                                                                                                                
[27145] "Sclerosing_Breast_Papilloma"                                                                                                                                          
[27146] "Ductal_Adenoma"                                                                                                                                                       
[27147] "Multiple_Breast_Papillomas"                                                                                                                                           
[27148] "Radiation_Anemia"                                                                                                                                                     
[27149] "Tuberculous_Bronchopneumonia"                                                                                                                                         
[27150] "Metaplastic_Carcinoma"                                                                                                                                                
[27151] "Secretory_Carcinoma"                                                                                                                                                  
[27152] "Lymphoma_by_Lukes-Collins_Classification_Antiquated"                                                                                                                  
[27153] "Senile_Sebaceous_Hyperplasia"                                                                                                                                         
[27154] "Asymmetric_Motor_Neuropathy"                                                                                                                                          
[27155] "Adolescent"                                                                                                                                                           
[27156] "Drug_Toxicity"                                                                                                                                                        
[27157] "Infant"                                                                                                                                                               
[27158] "Pedigree"                                                                                                                                                             
[27159] "Nasal"                                                                                                                                                                
[27160] "Prostatic"                                                                                                                                                            
[27161] "Personality_Traits"                                                                                                                                                   
[27162] "Neurotoxicity"                                                                                                                                                        
[27163] "Radiation_Toxicity"                                                                                                                                                   
[27164] "Lytic"                                                                                                                                                                
[27165] "Stage_0a"                                                                                                                                                             
[27166] "Stage_0is"                                                                                                                                                            
[27167] "Stage_I"                                                                                                                                                              
[27168] "Stage_IIA"                                                                                                                                                            
[27169] "Stage_IIB"                                                                                                                                                            
[27170] "Stage_IIC"                                                                                                                                                            
[27171] "Stage_III"                                                                                                                                                            
[27172] "Stage_IV"                                                                                                                                                             
[27173] "Stage_IVS"                                                                                                                                                            
[27174] "Stage_V"                                                                                                                                                              
[27175] "Intramuscular"                                                                                                                                                        
[27176] "Stage_IA"                                                                                                                                                             
[27177] "Stage_IB"                                                                                                                                                             
[27178] "Stage_IIIA"                                                                                                                                                           
[27179] "Stage_IIIB"                                                                                                                                                           
[27180] "Stage_IVA"                                                                                                                                                            
[27181] "Stage_IVB"                                                                                                                                                            
[27182] "Stage_IC"                                                                                                                                                             
[27183] "Stage_IIIC"                                                                                                                                                           
[27184] "Stage_IA1"                                                                                                                                                            
[27185] "Stage_IA2"                                                                                                                                                            
[27186] "Viral"                                                                                                                                                                
[27187] "Ultraviolet_A_radiation"                                                                                                                                              
[27188] "Ultraviolet_B_Radiation"                                                                                                                                              
[27189] "Cytotoxicity"                                                                                                                                                         
[27190] "Physical_Property"                                                                                                                                                    
[27191] "Toxicity"                                                                                                                                                             
[27192] "Intrathecal"                                                                                                                                                          
[27193] "Disease_Modifier"                                                                                                                                                     
[27194] "General_Modifier"                                                                                                                                                     
[27195] "Cardiotoxicity"                                                                                                                                                       
[27196] "Urinary_Tract_Toxicity"                                                                                                                                               
[27197] "Myocardial_Infarction"                                                                                                                                                
[27198] "New_York_Heart_Association_Classification_III_or_IV"                                                                                                                  
[27199] "Hereditary"                                                                                                                                                           
[27200] "Hypervascular"                                                                                                                                                        
[27201] "Autologous"                                                                                                                                                           
[27202] "Activate"                                                                                                                                                             
[27203] "Ultrasound_Therapy"                                                                                                                                                   
[27204] "Toxic"                                                                                                                                                                
[27205] "Preventive"                                                                                                                                                           
[27206] "Postoperative"                                                                                                                                                        
[27207] "Median"                                                                                                                                                               
[27208] "Irreversible_Toxicity"                                                                                                                                                
[27209] "Hydration"                                                                                                                                                            
[27210] "Retrospective"                                                                                                                                                        
[27211] "Biliary"                                                                                                                                                              
[27212] "unilateral"                                                                                                                                                           
[27213] "Karnofsky_Performance_Status"                                                                                                                                         
[27214] "Dose-Limiting"                                                                                                                                                        
[27215] "Bioavailable"                                                                                                                                                         
[27216] "Gynecologic"                                                                                                                                                          
[27217] "Transdermal"                                                                                                                                                          
[27218] "Inherited"                                                                                                                                                            
[27219] "Contiguous"                                                                                                                                                           
[27220] "Problem"                                                                                                                                                              
[27221] "Internal_Radiation"                                                                                                                                                   
[27222] "Dilate"                                                                                                                                                               
[27223] "Hormone_Responsive"                                                                                                                                                   
[27224] "Asymmetry"                                                                                                                                                            
[27225] "Epigastric"                                                                                                                                                           
[27226] "Germ-Free"                                                                                                                                                            
[27227] "Protozoal"                                                                                                                                                            
[27228] "Dose-dependent"                                                                                                                                                       
[27229] "Biochemical_Reactions"                                                                                                                                                
[27230] "Mutate"                                                                                                                                                               
[27231] "Nontoxic"                                                                                                                                                             
[27232] "Pontine"                                                                                                                                                              
[27233] "Attenuated"                                                                                                                                                           
[27234] "Intracolonic"                                                                                                                                                         
[27235] "Intratumoral"                                                                                                                                                         
[27236] "Inviable"                                                                                                                                                             
[27237] "Replicate"                                                                                                                                                            
[27238] "Electron_Beam"                                                                                                                                                        
[27239] "Intralesional"                                                                                                                                                        
[27240] "Investigational"                                                                                                                                                      
[27241] "Proliferative_Index"                                                                                                                                                  
[27242] "Metasynchronous"                                                                                                                                                      
[27243] "Isointense"                                                                                                                                                           
[27244] "Nonlytic"                                                                                                                                                             
[27245] "Nonseminomatous"                                                                                                                                                      
[27246] "Ovarian"                                                                                                                                                              
[27247] "Anal"                                                                                                                                                                 
[27248] "Intracavitary_Radiation"                                                                                                                                              
[27249] "Subependymal"                                                                                                                                                         
[27250] "Stage_0"                                                                                                                                                              
[27251] "Stage_IB1"                                                                                                                                                            
[27252] "Stage_IB2"                                                                                                                                                            
[27253] "Stage_II"                                                                                                                                                             
[27254] "Stage_IVC"                                                                                                                                                            
[27255] "Stage_A"                                                                                                                                                              
[27256] "Stage_B"                                                                                                                                                              
[27257] "Stage_B1"                                                                                                                                                             
[27258] "Stage_B2"                                                                                                                                                             
[27259] "Stage_C"                                                                                                                                                              
[27260] "Stage_D"                                                                                                                                                              
[27261] "Stage_D1"                                                                                                                                                             
[27262] "Stage_D2"                                                                                                                                                             
[27263] "Extensive_Stage"                                                                                                                                                      
[27264] "Limited_Stage"                                                                                                                                                        
[27265] "Stage_Unspecified"                                                                                                                                                    
[27266] "Hepatoblastoma_Stage"                                                                                                                                                 
[27267] "Postsurgical_Stage_I"                                                                                                                                                 
[27268] "Postsurgical_Stage_II"                                                                                                                                                
[27269] "Postsurgical_Stage_III"                                                                                                                                               
[27270] "Postsurgical_Stage_IV"                                                                                                                                                
[27271] "PRETEXT_Stage_1"                                                                                                                                                      
[27272] "PRETEXT_Stage_2"                                                                                                                                                      
[27273] "PRETEXT_Stage_3"                                                                                                                                                      
[27274] "PRETEXT_Stage_4"                                                                                                                                                      
[27275] "Disease_Grade_Modifier"                                                                                                                                               
[27276] "Grade_1"                                                                                                                                                              
[27277] "Grade_2"                                                                                                                                                              
[27278] "Grade_3"                                                                                                                                                              
[27279] "Grade_3a"                                                                                                                                                             
[27280] "Grade_3b"                                                                                                                                                             
[27281] "Grade_4"                                                                                                                                                              
[27282] "Intermediate_Grade"                                                                                                                                                   
[27283] "Gleason_Score_for_Prostate_Cancer"                                                                                                                                    
[27284] "Gleason_Grade_1"                                                                                                                                                      
[27285] "Gleason_Grade_2"                                                                                                                                                      
[27286] "Gleason_Grade_3"                                                                                                                                                      
[27287] "Gleason_Grade_4"                                                                                                                                                      
[27288] "Gleason_Grade_5"                                                                                                                                                      
[27289] "Gleason_Score_6"                                                                                                                                                      
[27290] "Gleason_Score_7"                                                                                                                                                      
[27291] "Gleason_Score_8"                                                                                                                                                      
[27292] "Gleason_Score_9"                                                                                                                                                      
[27293] "Gleason_Score_10"                                                                                                                                                     
[27294] "Gleason_Score_2"                                                                                                                                                      
[27295] "Gleason_Score_3"                                                                                                                                                      
[27296] "Gleason_Score_4"                                                                                                                                                      
[27297] "Gleason_Score_5"                                                                                                                                                      
[27298] "Disease_Morphology_Modifier"                                                                                                                                          
[27299] "Disease_Gross_Finding_Modifier"                                                                                                                                       
[27300] "Disease_Laboratory_Finding_Modifier"                                                                                                                                  
[27301] "Disease_Clinical_Modifier"                                                                                                                                            
[27302] "Disease_Treatment_Modifier"                                                                                                                                           
[27303] "Patient_Characteristics_Modifier"                                                                                                                                     
[27304] "Distantly_Metastatic"                                                                                                                                                 
[27305] "Locally_Metastatic"                                                                                                                                                   
[27306] "Gleason_Grade_for_Prostate_Cancer"                                                                                                                                    
[27307] "Disease_Stage_Modifier"                                                                                                                                               
[27308] "Pleomorphic"                                                                                                                                                          
[27309] "Statistically_Significant"                                                                                                                                            
[27310] "Gene-Modified"                                                                                                                                                        
[27311] "Cleaved_Cell"                                                                                                                                                         
[27312] "Renal_Tubular_Acidosis"                                                                                                                                               
[27313] "Acrylonitrile"                                                                                                                                                        
[27314] "Arsenic"                                                                                                                                                              
[27315] "Asthenia"                                                                                                                                                             
[27316] "Blood_Cell_Count"                                                                                                                                                     
[27317] "Bromelain"                                                                                                                                                            
[27318] "Caloric_Intake"                                                                                                                                                       
[27319] "Camphor"                                                                                                                                                              
[27320] "Oral_Candidiasis"                                                                                                                                                     
[27321] "Catechol"                                                                                                                                                             
[27322] "Decortication"                                                                                                                                                        
[27323] "Chlorine"                                                                                                                                                             
[27324] "Chondroitin_Sulfate"                                                                                                                                                  
[27325] "Collagen_Disease"                                                                                                                                                     
[27326] "Control_Group"                                                                                                                                                        
[27327] "Drug_Tolerance"                                                                                                                                                       
[27328] "Dysgeusia"                                                                                                                                                            
[27329] "Electroacupuncture"                                                                                                                                                   
[27330] "Embryo"                                                                                                                                                               
[27331] "Enema_Administration"                                                                                                                                                 
[27332] "Fluoride"                                                                                                                                                             
[27333] "Freeze-Drying"                                                                                                                                                        
[27334] "Gluconeogenesis"                                                                                                                                                      
[27335] "Glycolysis"                                                                                                                                                           
[27336] "Glycosaminoglycan"                                                                                                                                                    
[27337] "Hormone_Receptor"                                                                                                                                                     
[27338] "Horner_s_Syndrome"                                                                                                                                                    
[27339] "Hydrogen_Peroxide"                                                                                                                                                    
[27340] "_5-Hydroxyindoleacetic_Acid"                                                                                                                                          
[27341] "Hypnosis"                                                                                                                                                             
[27342] "Immunocompetence"                                                                                                                                                     
[27343] "Injection"                                                                                                                                                            
[27344] "Intramuscular_Injection"                                                                                                                                              
[27345] "Intravenous_Injection"                                                                                                                                                
[27346] "Inositol"                                                                                                                                                             
[27347] "Keratan_Sulfate"                                                                                                                                                      
[27348] "Klebsiella"                                                                                                                                                           
[27349] "Lactose"                                                                                                                                                              
[27350] "Laparoscope"                                                                                                                                                          
[27351] "Lentinan"                                                                                                                                                             
[27352] "Linear_Accelerator"                                                                                                                                                   
[27353] "Myelin"                                                                                                                                                               
[27354] "narcotic"                                                                                                                                                             
[27355] "Nebulizer"                                                                                                                                                            
[27356] "Nerve_Block"                                                                                                                                                          
[27357] "Occupational_Therapist"                                                                                                                                               
[27358] "Parachloroamphetamine"                                                                                                                                                
[27359] "Parasite"                                                                                                                                                             
[27360] "Paresthesia"                                                                                                                                                          
[27361] "Plant_Sterol"                                                                                                                                                         
[27362] "Polysaccharide"                                                                                                                                                       
[27363] "Prescription"                                                                                                                                                         
[27364] "Psychologist"                                                                                                                                                         
[27365] "Rabies"                                                                                                                                                               
[27366] "Radioactive_Fallout"                                                                                                                                                  
[27367] "Relaxation_Technique"                                                                                                                                                 
[27368] "Resting"                                                                                                                                                              
[27369] "Selection_Bias"                                                                                                                                                       
[27370] "Serum_Albumin"                                                                                                                                                        
[27371] "Sialic_Acid"                                                                                                                                                          
[27372] "Silicone"                                                                                                                                                             
[27373] "Social_Worker"                                                                                                                                                        
[27374] "Sulfuric_Acid"                                                                                                                                                        
[27375] "Survival_Rate"                                                                                                                                                        
[27376] "Syndrome"                                                                                                                                                             
[27377] "Telangiectasia"                                                                                                                                                       
[27378] "Thromboembolism"                                                                                                                                                      
[27379] "Anxiolytic"                                                                                                                                                           
[27380] "Virulence"                                                                                                                                                            
[27381] "Yttrium"                                                                                                                                                              
[27382] "Aluminum_Sulfate"                                                                                                                                                     
[27383] "Biochanin_A"                                                                                                                                                          
[27384] "Nitric_Acid"                                                                                                                                                          
[27385] "Polyphenol"                                                                                                                                                           
[27386] "Potassium_Hydroxide"                                                                                                                                                  
[27387] "Sodium_Sulfite"                                                                                                                                                       
[27388] "Viscotoxin"                                                                                                                                                           
[27389] "Patient-Controlled_Analgesia"                                                                                                                                         
[27390] "Mohs_Surgery"                                                                                                                                                         
[27391] "Obtundation"                                                                                                                                                          
[27392] "Photophobia"                                                                                                                                                          
[27393] "Enclomiphene"                                                                                                                                                         
[27394] "Intradermal"                                                                                                                                                          
[27395] "Barbiturate_Intoxication"                                                                                                                                             
[27396] "Transplanted_Pancreas_Complication"                                                                                                                                   
[27397] "Chorioallantoic_Membrane"                                                                                                                                             
[27398] "Intracellular"                                                                                                                                                        
[27399] "Scalpel"                                                                                                                                                              
[27400] "Electron_Microscope"                                                                                                                                                  
[27401] "Sensor"                                                                                                                                                               
[27402] "Phlebotomy"                                                                                                                                                           
[27403] "Disseminate"                                                                                                                                                          
[27404] "Endogenous"                                                                                                                                                           
[27405] "Focal"                                                                                                                                                                
[27406] "Latent"                                                                                                                                                               
[27407] "Biological"                                                                                                                                                           
[27408] "Bispecific_Monoclonal_Antibody"                                                                                                                                       
[27409] "Metabolic_Acidosis"                                                                                                                                                   
[27410] "Ingestion"                                                                                                                                                            
[27411] "Conditioned_Stimulus"                                                                                                                                                 
[27412] "Nutritionist"                                                                                                                                                         
[27413] "Bias"                                                                                                                                                                 
[27414] "Single_Blind_Study"                                                                                                                                                   
[27415] "Progression-free_Survival"                                                                                                                                            
[27416] "Valacyclovir"                                                                                                                                                         
[27417] "Foot_Fracture"                                                                                                                                                        
[27418] "Clinical_Practice_Guidelines"                                                                                                                                         
[27419] "Soft_Diet"                                                                                                                                                            
[27420] "Cobalt_60"                                                                                                                                                            
[27421] "Metabolic"                                                                                                                                                            
[27422] "Effector_Cell"                                                                                                                                                        
[27423] "Idiopathic"                                                                                                                                                           
[27424] "Oncolysis"                                                                                                                                                            
[27425] "Birt-Hogg-Dube_Syndrome"                                                                                                                                              
[27426] "Inhalation"                                                                                                                                                           
[27427] "Dysesthesia"                                                                                                                                                          
[27428] "Speech_Therapist"                                                                                                                                                     
[27429] "Dietitian"                                                                                                                                                            
[27430] "Scientist"                                                                                                                                                            
[27431] "Nothing_by_Mouth"                                                                                                                                                     
[27432] "Millimeter"                                                                                                                                                           
[27433] "Kilogram"                                                                                                                                                             
[27434] "Milligram"                                                                                                                                                            
[27435] "Milliliter"                                                                                                                                                           
[27436] "International_Unit"                                                                                                                                                   
[27437] "Retroperitoneal"                                                                                                                                                      
[27438] "Pathological_Staging"                                                                                                                                                 
[27439] "Condom"                                                                                                                                                               
[27440] "Sensory"                                                                                                                                                              
[27441] "Phantom_Limb_Pain"                                                                                                                                                    
[27442] "Mung_Bean"                                                                                                                                                            
[27443] "Chronic_Phase"                                                                                                                                                        
[27444] "Accelerated_Phase"                                                                                                                                                    
[27445] "Localization"                                                                                                                                                         
[27446] "Light_Microscope"                                                                                                                                                     
[27447] "Mold"                                                                                                                                                                 
[27448] "Urea_Nitrogen_Retired"                                                                                                                                                
[27449] "Burr_Hole"                                                                                                                                                            
[27450] "Phytochemical"                                                                                                                                                        
[27451] "Transplant_Surgeon"                                                                                                                                                   
[27452] "Molecular_Mass"                                                                                                                                                       
[27453] "Aqueous"                                                                                                                                                              
[27454] "Skin_Patch"                                                                                                                                                           
[27455] "Pathology_Report"                                                                                                                                                     
[27456] "Laboratory_Study"                                                                                                                                                     
[27457] "Controlled_Study"                                                                                                                                                     
[27458] "Uncontrolled_Study"                                                                                                                                                   
[27459] "Predictive_Factor"                                                                                                                                                    
[27460] "Intoxication"                                                                                                                                                         
[27461] "Filler"                                                                                                                                                               
[27462] "Stage_Is"                                                                                                                                                             
[27463] "Insomnia"                                                                                                                                                             
[27464] "Viscera"                                                                                                                                                              
[27465] "UGT1A1_Protein"                                                                                                                                                       
[27466] "Enema"                                                                                                                                                                
[27467] "Panacea"                                                                                                                                                              
[27468] "Squamous_Cell_Carcinoma_In_Situ_of_the_Nipple"                                                                                                                        
[27469] "Outpatient"                                                                                                                                                           
[27470] "Nutrition"                                                                                                                                                            
[27471] "Randomized"                                                                                                                                                           
[27472] "Experimental"                                                                                                                                                         
[27473] "Pilocytic"                                                                                                                                                            
[27474] "Physician_Data_Query"                                                                                                                                                 
[27475] "Advanced_Adult_Primary_Hepatocellular_Carcinoma"                                                                                                                      
[27476] "Aggressive_Lymphoma"                                                                                                                                                  
[27477] "Stage_I_Mesothelioma"                                                                                                                                                 
[27478] "Stage_II_Mesothelioma"                                                                                                                                                
[27479] "Stage_III_Mesothelioma"                                                                                                                                               
[27480] "Stage_IV_Mesothelioma"                                                                                                                                                
[27481] "APC_Vaccine"                                                                                                                                                          
[27482] "Whole_Cell_Vaccine"                                                                                                                                                   
[27483] "Dendritic_Cell_Vaccine"                                                                                                                                               
[27484] "Breast_Carcinoma_Metastatic_to_the_Skin"                                                                                                                              
[27485] "High-Risk_Cancer"                                                                                                                                                     
[27486] "Endothelin_Receptor_Antagonist"                                                                                                                                       
[27487] "Lhermitte_s_Sign"                                                                                                                                                     
[27488] "Normal_Renal_Arteriogram"                                                                                                                                             
[27489] "Aggravated_Acne"                                                                                                                                                      
[27490] "Normal_Carotid_Arteriogram"                                                                                                                                           
[27491] "Normal_Cerebral_Arteriogram"                                                                                                                                          
[27492] "Normal_Coronary_Arteriogram"                                                                                                                                          
[27493] "Booster"                                                                                                                                                              
[27494] "Cisclomiphene"                                                                                                                                                        
[27495] "stage_III_cancer_of_the_uterus"                                                                                                                                       
[27496] "stage_II_cancer_of_the_uterus"                                                                                                                                        
[27497] "stage_I_cancer_of_the_uterus"                                                                                                                                         
[27498] "stage_IV_cancer_of_the_uterus"                                                                                                                                        
[27499] "Endocervical_Carcinoma"                                                                                                                                               
[27500] "Yttrium_Y90_or_Indium_111_Labeled_Humanized_Monoclonal_Antibody_BrE-3"                                                                                                
[27501] "Commercial_or_Non-CTEP_IND_agent"                                                                                                                                     
[27502] "Anti-Idiotype_Specified_Monoclonal_Antibody"                                                                                                                          
[27503] "Follicle_Centre_Lymphoma_Follicular_Grade_I_II_III_Stage_IV"                                                                                                          
[27504] "Pancreatic_Non-Functioning_Delta_Cell_Neoplasm"                                                                                                                       
[27505] "Endothelin-1_Protein_Receptor_Antagonist"                                                                                                                             
[27506] "Breast_Implant"                                                                                                                                                       
[27507] "Breast_Prosthesis_Implantation"                                                                                                                                       
[27508] "Stage_IV_Testicular_Non-Seminomatous_Germ_Cell_Tumor"                                                                                                                 
[27509] "Aerobic"                                                                                                                                                              
[27510] "Alkalinization"                                                                                                                                                       
[27511] "Allogenic"                                                                                                                                                            
[27512] "Alteration"                                                                                                                                                           
[27513] "Angelica_Root"                                                                                                                                                        
[27514] "Control_Animal"                                                                                                                                                       
[27515] "Anti-inflammatory"                                                                                                                                                    
[27516] "Carcinostatic"                                                                                                                                                        
[27517] "Cauterize"                                                                                                                                                            
[27518] "Cerebellopontine"                                                                                                                                                     
[27519] "Chiasma"                                                                                                                                                              
[27520] "Dukes_Classification"                                                                                                                                                 
[27521] "Cordectomy"                                                                                                                                                           
[27522] "de_novo"                                                                                                                                                              
[27523] "Derivative"                                                                                                                                                           
[27524] "Tropical_Disease"                                                                                                                                                     
[27525] "Dyscrasia"                                                                                                                                                            
[27526] "Extrahepatic"                                                                                                                                                         
[27527] "Heterogeneous"                                                                                                                                                        
[27528] "Heterogenous"                                                                                                                                                         
[27529] "Hypothesis"                                                                                                                                                           
[27530] "Immunocompetent"                                                                                                                                                      
[27531] "Intracavitary"                                                                                                                                                        
[27532] "Irradiated"                                                                                                                                                           
[27533] "Dark-Field_Microscope"                                                                                                                                                
[27534] "Motor"                                                                                                                                                                
[27535] "Nephrotoxic"                                                                                                                                                          
[27536] "Neuroepithelial"                                                                                                                                                      
[27537] "Neurotropism"                                                                                                                                                         
[27538] "Cold_Nodule"                                                                                                                                                          
[27539] "Hot_Nodule"                                                                                                                                                           
[27540] "Oncolytic"                                                                                                                                                            
[27541] "Perioperative"                                                                                                                                                        
[27542] "Phosphorous"                                                                                                                                                          
[27543] "Pluripotent"                                                                                                                                                          
[27544] "Proliferating"                                                                                                                                                        
[27545] "Septate"                                                                                                                                                              
[27546] "Sphincter"                                                                                                                                                            
[27547] "Hand-Foot_Syndrome"                                                                                                                                                   
[27548] "Totipotent"                                                                                                                                                           
[27549] "Tumor_Burden"                                                                                                                                                         
[27550] "Vaccinated"                                                                                                                                                           
[27551] "Vasomotor"                                                                                                                                                            
[27552] "Virulent"                                                                                                                                                             
[27553] "NCI_Administrative_Concepts"                                                                                                                                          
[27554] "B-Cell_Development"                                                                                                                                                   
[27555] "_10q23_2-q23_33"                                                                                                                                                      
[27556] "Peptidase"                                                                                                                                                            
[27557] "Topical_Anti-Infective_Agent"                                                                                                                                         
[27558] "Computed_Tomography_Colonography"                                                                                                                                     
[27559] "Pancreatic_Delta_Cell_Neoplasm"                                                                                                                                       
[27560] "Asthma"                                                                                                                                                               
[27561] "Allied_Health_Profession"                                                                                                                                             
[27562] "CASP10_Gene"                                                                                                                                                          
[27563] "Olfactory_Bulb"                                                                                                                                                       
[27564] "Primitive_Streak"                                                                                                                                                     
[27565] "Cysteine_Protease_Gene"                                                                                                                                               
[27566] "CTSB_Gene"                                                                                                                                                            
[27567] "CTSD_Gene"                                                                                                                                                            
[27568] "National_Origin"                                                                                                                                                      
[27569] "Quantitative_Reverse_Transcriptase_PCR"                                                                                                                               
[27570] "Chloroacetate_Esterase_Staining_Method"                                                                                                                               
[27571] "Aspartyl_Protease"                                                                                                                                                    
[27572] "Wilson_s_Staining_Method"                                                                                                                                             
[27573] "Synaptophysin_and_Hematoxylin_Staining_Method"                                                                                                                        
[27574] "Alpha_Naphthyl_Butyrate_Esterase_Staining_Method"                                                                                                                     
[27575] "Alpha_Naphthyl_Acetate_Esterase_Staining_Method"                                                                                                                      
[27576] "Somatostatin"                                                                                                                                                         
[27577] "Growth_Hormone-Releasing_Hormone"                                                                                                                                     
[27578] "Thyrotropin-Releasing_Hormone"                                                                                                                                        
[27579] "Sex"                                                                                                                                                                  
[27580] "Inbred_Strain"                                                                                                                                                        
[27581] "CASP9_Gene"                                                                                                                                                           
[27582] "_1p36_3-p36_1"                                                                                                                                                        
[27583] "Caspase-9"                                                                                                                                                            
[27584] "Retired_Concepts"                                                                                                                                                     
[27585] "CASP4_Gene"                                                                                                                                                           
[27586] "_11q22_2-q22_3"                                                                                                                                                       
[27587] "Caspase-4"                                                                                                                                                            
[27588] "Nipple_Carcinoma"                                                                                                                                                     
[27589] "CASP5_Gene"                                                                                                                                                           
[27590] "Caspase-5"                                                                                                                                                            
[27591] "CASP6_Gene"                                                                                                                                                           
[27592] "Caspase-6"                                                                                                                                                            
[27593] "_5p13_2"                                                                                                                                                              
[27594] "CASP7_Gene"                                                                                                                                                           
[27595] "Caspase-7"                                                                                                                                                            
[27596] "Small_Nuclear_Ribonucleoprotein_Particle"                                                                                                                             
[27597] "Alpha_Naphthyl_Esterase_Staining_Method"                                                                                                                              
[27598] "EPO_Gene"                                                                                                                                                             
[27599] "Chromosomal_Nondisjunction"                                                                                                                                           
[27600] "Reciprocal_Translocation"                                                                                                                                             
[27601] "Paracentric_Inversion"                                                                                                                                                
[27602] "Pericentric_Inversion"                                                                                                                                                
[27603] "Robertsonian_Translocation"                                                                                                                                           
[27604] "Meiotic_Nondisjunction"                                                                                                                                               
[27605] "Mitotic_Nondisjunction"                                                                                                                                               
[27606] "Tetraploidy"                                                                                                                                                          
[27607] "CSF1_Gene"                                                                                                                                                            
[27608] "Philadelphia_Chromosome"                                                                                                                                              
[27609] "Aberrant_Chromosome"                                                                                                                                                  
[27610] "hnRNA"                                                                                                                                                                
[27611] "Ultrasonogram"                                                                                                                                                        
[27612] "Oxygenase"                                                                                                                                                            
[27613] "Subcellular_Anatomy"                                                                                                                                                  
[27614] "CTSL_Gene"                                                                                                                                                            
[27615] "_9q21-q22"                                                                                                                                                            
[27616] "CTSH_Gene"                                                                                                                                                            
[27617] "_5p13_1-p12"                                                                                                                                                          
[27618] "GDNF_Gene"                                                                                                                                                            
[27619] "Neurturin"                                                                                                                                                            
[27620] "Macrophage_Migration_Inhibitory_Factor"                                                                                                                               
[27621] "Small_Inducible_Cytokine-B9"                                                                                                                                          
[27622] "F7_Gene"                                                                                                                                                              
[27623] "F8_Gene"                                                                                                                                                              
[27624] "Inhibin_Alpha"                                                                                                                                                        
[27625] "Inhibin_Beta-A"                                                                                                                                                       
[27626] "Inhibin_Beta-B"                                                                                                                                                       
[27627] "Insulin_Receptor_Substrate-1"                                                                                                                                         
[27628] "Insulin_Receptor_Substrate-2"                                                                                                                                         
[27629] "Insulin_Receptor_Substrate-4"                                                                                                                                         
[27630] "Coagulation_Factor_Gene"                                                                                                                                              
[27631] "F9_Gene"                                                                                                                                                              
[27632] "Coagulation_Factor-IX"                                                                                                                                                
[27633] "VWF_Gene"                                                                                                                                                             
[27634] "_12p13_3"                                                                                                                                                             
[27635] "Kallikrein-15_Protein"                                                                                                                                                
[27636] "Cell_Movement"                                                                                                                                                        
[27637] "_8q21_12"                                                                                                                                                             
[27638] "_7q31_1-q31_2"                                                                                                                                                        
[27639] "Integrin_Beta-2"                                                                                                                                                      
[27640] "Integrin_Beta-4"                                                                                                                                                      
[27641] "Cellular_Infiltration"                                                                                                                                                
[27642] "Janus_Kinase-3"                                                                                                                                                       
[27643] "Janus_Kinase-1"                                                                                                                                                       
[27644] "Janus_Kinase-2"                                                                                                                                                       
[27645] "Motivation"                                                                                                                                                           
[27646] "Vascular_Endothelial_Growth_Factor_Receptor-2"                                                                                                                        
[27647] "Biochemical_Process"                                                                                                                                                  
[27648] "Manic_Fringe_Protein"                                                                                                                                                 
[27649] "Iodinated_Contrast_Dye"                                                                                                                                               
[27650] "Wobe-Mugos_E"                                                                                                                                                         
[27651] "Bismuth_Bi213_Monoclonal_Antibody_M195"                                                                                                                               
[27652] "Globo_H-GM2-Lewis-y-MUC1-32-mer-TF_c_Tn_c_KLH_Conjugate_Vaccine"                                                                                                      
[27653] "Globo-H-GM2-Lewis-y-MUC1-32-mer-TF_c_Tn_c_KLH-Conjugate-Vaccine_QS21"                                                                                                 
[27654] "Ion_Channel_Protein"                                                                                                                                                  
[27655] "Nuclear_Translocation"                                                                                                                                                
[27656] "Transport_Reaction"                                                                                                                                                   
[27657] "Interleukin-12A"                                                                                                                                                      
[27658] "Interleukin-12B"                                                                                                                                                      
[27659] "Fusion_Gene"                                                                                                                                                          
[27660] "Nitric_Oxide_Synthetase"                                                                                                                                              
[27661] "Mitochondrial_DNA"                                                                                                                                                    
[27662] "Heterodimerization"                                                                                                                                                   
[27663] "Homodimerization"                                                                                                                                                     
[27664] "Glutamic_Acid_Hydrochloride"                                                                                                                                          
[27665] "Sickle_Cell_Dactylitis"                                                                                                                                               
[27666] "Drug_Implant"                                                                                                                                                         
[27667] "Double_Stranded_RNA_Virus"                                                                                                                                            
[27668] "FOXO3A_Gene"                                                                                                                                                          
[27669] "Forkhead_Box-O3A_Protein"                                                                                                                                             
[27670] "JAW1-Related_Protein"                                                                                                                                                 
[27671] "Musculin"                                                                                                                                                             
[27672] "AHR_Gene"                                                                                                                                                             
[27673] "_7p15"                                                                                                                                                                
[27674] "AMFR_Gene"                                                                                                                                                            
[27675] "Macrophage_Stimulating-1_Receptor"                                                                                                                                    
[27676] "_16q21"                                                                                                                                                               
[27677] "Muscle-Specific_Kinase"                                                                                                                                               
[27678] "ITGAX_Gene"                                                                                                                                                           
[27679] "CDK5_Gene"                                                                                                                                                            
[27680] "AZU1_Gene"                                                                                                                                                            
[27681] "CEBPE_Gene"                                                                                                                                                           
[27682] "Transport_Protein_Gene"                                                                                                                                               
[27683] "BDNF_Gene"                                                                                                                                                            
[27684] "_12p13_1-p12"                                                                                                                                                         
[27685] "APP_Gene"                                                                                                                                                             
[27686] "_21q21_3"                                                                                                                                                             
[27687] "AR_Gene"                                                                                                                                                              
[27688] "Xq11_2-q12"                                                                                                                                                           
[27689] "PLG_Gene"                                                                                                                                                             
[27690] "BTC_Gene"                                                                                                                                                             
[27691] "TFAP2B_Gene"                                                                                                                                                          
[27692] "_6p21-p12"                                                                                                                                                            
[27693] "Alkyl-Guanine_Transferase_Inhibitor"                                                                                                                                  
[27694] "Chromosome_Segregation"                                                                                                                                               
[27695] "J5_Antiserum"                                                                                                                                                         
[27696] "Synchrovax_SEM_Plasmid_DNA_Vaccine"                                                                                                                                   
[27697] "Recombinant_Adenovirus-hIFN-beta"                                                                                                                                     
[27698] "Globo-H-GM2-Lewis-y-MUC1-32_aa_sTn_c_TF_c_Tn_c_KLH_Conjugate_Vaccine"                                                                                                 
[27699] "Globo-H-GM2-Lewis-y-MUC1-32_aa_sTn_c_TF_c_Tn_c_KLH-Conjugate-Vaccine_QS21"                                                                                            
[27700] "Aryl_Hydrocarbon_Receptor_Nuclear_Translocator"                                                                                                                       
[27701] "Death"                                                                                                                                                                
[27702] "_9q22_31"                                                                                                                                                             
[27703] "MAX_Interacting_Protein-1"                                                                                                                                            
[27704] "M-Phase_Promoting_Factor"                                                                                                                                             
[27705] "Neurotrophic_Tyrosine_Kinase_Receptor_Type-1"                                                                                                                         
[27706] "CDC2_Gene"                                                                                                                                                            
[27707] "Xq22_2"                                                                                                                                                               
[27708] "Nerve_Growth_Factor_Receptor_Associated_Protein-1"                                                                                                                    
[27709] "_14q13_2"                                                                                                                                                             
[27710] "G2-M_Transition"                                                                                                                                                      
[27711] "Neuromedin-B_Receptor"                                                                                                                                                
[27712] "NMYC_Interactor"                                                                                                                                                      
[27713] "Protein_Fragment"                                                                                                                                                     
[27714] "CTLA4_Gene"                                                                                                                                                           
[27715] "_2q34"                                                                                                                                                                
[27716] "MYB_Gene"                                                                                                                                                             
[27717] "CBFA2T1_Gene"                                                                                                                                                         
[27718] "NR3C1_Gene"                                                                                                                                                           
[27719] "SLC2A1_Gene"                                                                                                                                                          
[27720] "ENG_Gene"                                                                                                                                                             
[27721] "FN1_Gene"                                                                                                                                                             
[27722] "GATA1_Gene"                                                                                                                                                           
[27723] "_6p24_1"                                                                                                                                                              
[27724] "EDN1_Gene"                                                                                                                                                            
[27725] "Harvey_Murine_Sarcoma_Virus"                                                                                                                                          
[27726] "Ethylchlorformate_Vaccine"                                                                                                                                            
[27727] "CpG_7909"                                                                                                                                                             
[27728] "psiCRIP-MFG-S-TK1-67"                                                                                                                                                 
[27729] "H2AX_Gene"                                                                                                                                                            
[27730] "_11q23_2-q23_3"                                                                                                                                                       
[27731] "_7p14-p12"                                                                                                                                                            
[27732] "HLA-A_Gene"                                                                                                                                                           
[27733] "Transcription_Elongation"                                                                                                                                             
[27734] "ID2_Gene"                                                                                                                                                             
[27735] "IGFBP1_Gene"                                                                                                                                                          
[27736] "IGFBP2_Gene"                                                                                                                                                          
[27737] "_6q14_3"                                                                                                                                                              
[27738] "_4q31"                                                                                                                                                                
[27739] "IL1A_Gene"                                                                                                                                                            
[27740] "IL1B_Gene"                                                                                                                                                            
[27741] "Cell_Maturation"                                                                                                                                                      
[27742] "IL3_Gene"                                                                                                                                                             
[27743] "IL4_Gene"                                                                                                                                                             
[27744] "Kinase"                                                                                                                                                               
[27745] "IL7_Gene"                                                                                                                                                             
[27746] "IL9_Gene"                                                                                                                                                             
[27747] "IL10_Gene"                                                                                                                                                            
[27748] "IL11_Gene"                                                                                                                                                            
[27749] "IL14_Gene"                                                                                                                                                            
[27750] "IFNG_Gene"                                                                                                                                                            
[27751] "IL15_Gene"                                                                                                                                                            
[27752] "IL16_Gene"                                                                                                                                                            
[27753] "_15q26_3"                                                                                                                                                             
[27754] "LDLR_Gene"                                                                                                                                                            
[27755] "IL17_Gene"                                                                                                                                                            
[27756] "IL18_Gene"                                                                                                                                                            
[27757] "KLRA1_Gene"                                                                                                                                                           
[27758] "_12p13-p12"                                                                                                                                                           
[27759] "IL19_Gene"                                                                                                                                                            
[27760] "Interleukin-19"                                                                                                                                                       
[27761] "Transcription_Process"                                                                                                                                                
[27762] "Transcription_Termination"                                                                                                                                            
[27763] "E7_86-93_Lipopeptide"                                                                                                                                                 
[27764] "Mouse_Pulmonary_Disorder"                                                                                                                                             
[27765] "Pulmonary_Proliferative_Lesions_of_the_Mouse"                                                                                                                         
[27766] "Epithelial_Proliferative_Lesions_of_the_Mouse_Pulmonary_System"                                                                                                       
[27767] "Airway_Epithelial_Hyperplasia_of_the_Mouse_Pulmonary_System"                                                                                                          
[27768] "Alveoli_Epithelial_Hyperplasia_of_the_Mouse_Pulmonary_System"                                                                                                         
[27769] "Immunoglobulin_Family_Protein"                                                                                                                                        
[27770] "Diffuse_Idiopathic_Pulmonary_Neuroendocrine_Cell_Hyperplasia_of_the_Mouse_Pulmonary_System"                                                                           
[27771] "MAD_Gene"                                                                                                                                                             
[27772] "MAX_Dimerization_Protein-1"                                                                                                                                           
[27773] "PCNA_Gene"                                                                                                                                                            
[27774] "MLANA_Gene"                                                                                                                                                           
[27775] "_9p24_1"                                                                                                                                                              
[27776] "Antitumor_Response"                                                                                                                                                   
[27777] "PURA_Gene"                                                                                                                                                            
[27778] "NCOR2_Gene"                                                                                                                                                           
[27779] "_12q24"                                                                                                                                                               
[27780] "ZNF145_Gene"                                                                                                                                                          
[27781] "MKI67_Gene"                                                                                                                                                           
[27782] "_10q25-qter"                                                                                                                                                          
[27783] "SSTR2_Gene"                                                                                                                                                           
[27784] "SSTR5_Gene"                                                                                                                                                           
[27785] "NCOR1_Gene"                                                                                                                                                           
[27786] "Hospice_Nursing"                                                                                                                                                      
[27787] "Minichromosome_Maintenance_Protein-2"                                                                                                                                 
[27788] "NID_Gene"                                                                                                                                                             
[27789] "_1q43"                                                                                                                                                                
[27790] "Nidogen"                                                                                                                                                              
[27791] "RELA_Gene"                                                                                                                                                            
[27792] "_11q12-q13"                                                                                                                                                           
[27793] "_1q22-q23"                                                                                                                                                            
[27794] "POU2F1_Gene"                                                                                                                                                          
[27795] "_19q13_31"                                                                                                                                                            
[27796] "POU2F2_Gene"                                                                                                                                                          
[27797] "TRADD_Gene"                                                                                                                                                           
[27798] "TRAF2_Gene"                                                                                                                                                           
[27799] "Retrograde_Pyelogram"                                                                                                                                                 
[27800] "PLCG2_Gene"                                                                                                                                                           
[27801] "PGR_Gene"                                                                                                                                                             
[27802] "PRLR_Gene"                                                                                                                                                            
[27803] "Telomeric_Repeat_Binding_Factor-2"                                                                                                                                    
[27804] "Signal_Transducer_and_Activator_of_Transcription-1"                                                                                                                   
[27805] "Signal_Transducer_and_Activator_of_Transcription-2"                                                                                                                   
[27806] "THBS1_Gene"                                                                                                                                                           
[27807] "_15q15"                                                                                                                                                               
[27808] "THBS2_Gene"                                                                                                                                                           
[27809] "Signal_Transducer_and_Activator_of_Transcription-3"                                                                                                                   
[27810] "Signal_Transducer_and_Activator_of_Transcription-4"                                                                                                                   
[27811] "Placental_Growth_Factor"                                                                                                                                              
[27812] "STAT5B_Gene"                                                                                                                                                          
[27813] "Signal_Transducer_and_Activator_of_Transcription-5A"                                                                                                                  
[27814] "Signal_Transducer_and_Activator_of_Transcription-5B"                                                                                                                  
[27815] "Signal_Transducer_and_Activator_of_Transcription-6"                                                                                                                   
[27816] "Activator_of_S_Phase_Kinase"                                                                                                                                          
[27817] "CDC7L1_Kinase_Complex"                                                                                                                                                
[27818] "CDC45-Related_Protein"                                                                                                                                                
[27819] "_22q12_1-q13_2"                                                                                                                                                       
[27820] "TIMP1_Gene"                                                                                                                                                           
[27821] "Allogeneic_Lymphocytes"                                                                                                                                               
[27822] "Replication_Initiation"                                                                                                                                               
[27823] "CDC7_Cell_Division_Cycle-7_Protein"                                                                                                                                   
[27824] "TIMP2_Gene"                                                                                                                                                           
[27825] "TIMP3_Gene"                                                                                                                                                           
[27826] "Autologous_Lymphocytes"                                                                                                                                               
[27827] "AUT-OV-ALVAC-hB7_1_Vaccine"                                                                                                                                           
[27828] "Cell_Cycle_Progression"                                                                                                                                               
[27829] "Minichromosome_Maintenance_Protein-3"                                                                                                                                 
[27830] "Pre-Replication_Complex"                                                                                                                                              
[27831] "Transcriptional_Co-Activator-CRSP150"                                                                                                                                 
[27832] "Cofactor_Required_for_SP1_Activation"                                                                                                                                 
[27833] "Transcriptional_Co-Activator-CRSP130"                                                                                                                                 
[27834] "Transcriptional_Co-Activator-CRSP77"                                                                                                                                  
[27835] "Transcriptional_Co-Activator-CRSP70"                                                                                                                                  
[27836] "Transcriptional_Co-Activator-CRSP34"                                                                                                                                  
[27837] "Transcriptional_Co-Activator-CRSP33"                                                                                                                                  
[27838] "CRYPTIC_Protein"                                                                                                                                                      
[27839] "beta-Lapachone"                                                                                                                                                       
[27840] "Therapeutic_70-kD_Heat-Shock_Protein"                                                                                                                                 
[27841] "Baculoviral_IAP_Repeat-Containing_Protein-6"                                                                                                                          
[27842] "Laniquidar"                                                                                                                                                           
[27843] "Therapeutic_Tumor_Infiltrating_Lymphocytes"                                                                                                                           
[27844] "_5q23-q32"                                                                                                                                                            
[27845] "TFIIA-Alpha-Beta-Like_Factor"                                                                                                                                         
[27846] "_19q13_13"                                                                                                                                                            
[27847] "Activator_of_S_Phase_Kinase_retired"                                                                                                                                  
[27848] "_9p12"                                                                                                                                                                
[27849] "TAF3B2"                                                                                                                                                               
[27850] "BCL7A_Protein"                                                                                                                                                        
[27851] "B-Cell_Lymphoma-9_Protein"                                                                                                                                            
[27852] "Orthologous_Gene"                                                                                                                                                     
[27853] "Homologous_Gene"                                                                                                                                                      
[27854] "RNA_Polymerase-III_Transcription_Initiation_Factor-BRF2"                                                                                                              
[27855] "Transcription_Factor-Like_Nuclear_Regulator"                                                                                                                          
[27856] "Xq26-q28"                                                                                                                                                             
[27857] "General_Transcription_Factor_3B_90-kD_Subunit"                                                                                                                        
[27858] "Activin-A_Type-B_Receptor"                                                                                                                                            
[27859] "Aryl_Hydrocarbon_Receptor_Nuclear_Translocator-2"                                                                                                                     
[27860] "Brain-Specific_Angiogenesis_Inhibitor-2"                                                                                                                              
[27861] "Brain-Specific_Angiogenesis_Inhibitor-3"                                                                                                                              
[27862] "BAI1-Associated_Protein-1"                                                                                                                                            
[27863] "Anti-human_Chorionic_Gonadotropin_Vaccine"                                                                                                                            
[27864] "Bridging_Integrator-1_Protein"                                                                                                                                        
[27865] "Recombinant_KSA_Glycoprotein"                                                                                                                                         
[27866] "MART-1_Antigen"                                                                                                                                                       
[27867] "Therapeutic_Tyrosinase-Related_Protein-1"                                                                                                                             
[27868] "Small_Inducible_Cytokine-A13"                                                                                                                                         
[27869] "Small_Inducible_Cytokine-A14"                                                                                                                                         
[27870] "Small_Inducible_Cytokine-A3-Like-1_Protein"                                                                                                                           
[27871] "Small_Inducible_Cytokine-A15"                                                                                                                                         
[27872] "Small_Inducible_Cytokine-A17"                                                                                                                                         
[27873] "Small_Inducible_Cytokine-A7"                                                                                                                                          
[27874] "Small_Inducible_Cytokine-A18"                                                                                                                                         
[27875] "Small_Inducible_Cytokine-A19"                                                                                                                                         
[27876] "Small_Inducible_Cytokine-A20"                                                                                                                                         
[27877] "Small_Inducible_Cytokine-A22"                                                                                                                                         
[27878] "Small_Inducible_Cytokine-A24"                                                                                                                                         
[27879] "Small_Inducible_Cytokine-A25"                                                                                                                                         
[27880] "Small_Inducible_Cytokine-A23_Isoform-CKBeta8"                                                                                                                         
[27881] "Small_Inducible_Cytokine-A26"                                                                                                                                         
[27882] "Small_Inducible_Cytokine-A27"                                                                                                                                         
[27883] "Ideal"                                                                                                                                                                
[27884] "Body_Weight"                                                                                                                                                          
[27885] "Punch_Biopsy"                                                                                                                                                         
[27886] "Tracheobronchial"                                                                                                                                                     
[27887] "Subsegmental_Lymph_Node"                                                                                                                                              
[27888] "Enhancing_Lesion"                                                                                                                                                     
[27889] "Reader"                                                                                                                                                               
[27890] "C-X-C_Motif_Chemokine_Receptor-6"                                                                                                                                     
[27891] "Spiculate"                                                                                                                                                            
[27892] "Cytochrome-P450-2C9"                                                                                                                                                  
[27893] "Phosphatidylcholine_Biosynthesis"                                                                                                                                     
[27894] "Chromosome_Cohesion"                                                                                                                                                  
[27895] "_10p12_1"                                                                                                                                                             
[27896] "Innate_Bone_Remodeling"                                                                                                                                               
[27897] "Unclassified_Drugs_and_Chemicals"                                                                                                                                     
[27898] "Small_Inducible_Cytokine-B10"                                                                                                                                         
[27899] "Small_Inducible_Cytokine-B11"                                                                                                                                         
[27900] "Stromal_Cell-Derived_Factor-1"                                                                                                                                        
[27901] "_161-180_ESO-1"                                                                                                                                                       
[27902] "_H115D_VHL35"                                                                                                                                                         
[27903] "_1_9-Nonanediol"                                                                                                                                                      
[27904] "_1-Aminocyclopentane"                                                                                                                                                 
[27905] "_117-126_FGF-5_Peptide"                                                                                                                                               
[27906] "_11D10_AluGel_Anti-Idiotype_Monoclonal_Antibody"                                                                                                                      
[27907] "_27-35_27L_MART-1"                                                                                                                                                    
[27908] "_3H1_Aluminum_Hydroxide-Precipitated_Anti-Idiotype_Monoclonal_Antibody"                                                                                               
[27909] "_5-HP"                                                                                                                                                                
[27910] "_8-Azaguanine"                                                                                                                                                        
[27911] "_9-Ethyl_6-Mercaptopurine"                                                                                                                                            
[27912] "_9H-Purine-6Thio-98D"                                                                                                                                                 
[27913] "A_and_D_Ointment"                                                                                                                                                     
[27914] "Alpha-Thioguanine_Deoxyriboside"                                                                                                                                      
[27915] "Acronycine"                                                                                                                                                           
[27916] "ADA_Transduced_T-Cell"                                                                                                                                                
[27917] "Ametantrone_Acetate"                                                                                                                                                  
[27918] "Amino-Arginine"                                                                                                                                                       
[27919] "Amygdalin"                                                                                                                                                            
[27920] "Aphidicoline_Glycinate"                                                                                                                                               
[27921] "Azotomycin"                                                                                                                                                           
[27922] "Abacavir"                                                                                                                                                             
[27923] "Denatured_Absolute_Ethanol"                                                                                                                                           
[27924] "Acebutolol"                                                                                                                                                           
[27925] "Acetaminophen_3"                                                                                                                                                      
[27926] "Acetaminophen_Diphenhydramine"                                                                                                                                        
[27927] "Acetazolamide"                                                                                                                                                        
[27928] "Ad_CMV_I_kappaB_alpha"                                                                                                                                                
[27929] "Adefovir"                                                                                                                                                             
[27930] "Allergy_Shot"                                                                                                                                                         
[27931] "Aloe_Vera"                                                                                                                                                            
[27932] "Alprostadil"                                                                                                                                                          
[27933] "Aluminum_Magnesium"                                                                                                                                                   
[27934] "Amantadine_Hydrochloride"                                                                                                                                             
[27935] "Amitriptyline"                                                                                                                                                        
[27936] "Amlodipine_Besylate"                                                                                                                                                  
[27937] "Ammonium_Lactate"                                                                                                                                                     
[27938] "Amphetamine"                                                                                                                                                          
[27939] "Ampicillin_Sodium-Sulbactam_Sodium"                                                                                                                                   
[27940] "Amprenavir"                                                                                                                                                           
[27941] "Anagrelide"                                                                                                                                                           
[27942] "Anagrelide_Hydrochloride"                                                                                                                                             
[27943] "Anthralin"                                                                                                                                                            
[27944] "Apheresis"                                                                                                                                                            
[27945] "Aquaphor"                                                                                                                                                             
[27946] "Argatroban"                                                                                                                                                           
[27947] "Astemizole"                                                                                                                                                           
[27948] "Atazanavir"                                                                                                                                                           
[27949] "Atenolol"                                                                                                                                                             
[27950] "Atorvastatin"                                                                                                                                                         
[27951] "Atovoquone"                                                                                                                                                           
[27952] "Atracuruim_Besylate"                                                                                                                                                  
[27953] "Atropine"                                                                                                                                                             
[27954] "Attapulgite"                                                                                                                                                          
[27955] "Autologous_Epstein-Barr_Virus-Specific_Cytotoxic_T_Lymphocytes"                                                                                                       
[27956] "Azithromycin"                                                                                                                                                         
[27957] "Aztreonam"                                                                                                                                                            
[27958] "B3_90YB3_111Y-B3"                                                                                                                                                     
[27959] "Bactobolin"                                                                                                                                                           
[27960] "Baculovirus_CEA_Protein_Vaccine"                                                                                                                                      
[27961] "Baculovirus-Derived_PSA_Protein"                                                                                                                                      
[27962] "BLED"                                                                                                                                                                 
[27963] "Breflate"                                                                                                                                                             
[27964] "BVCPP"                                                                                                                                                                
[27965] "Bacitracin_Zinc"                                                                                                                                                      
[27966] "Baclofen"                                                                                                                                                             
[27967] "Barium_Sulfate"                                                                                                                                                       
[27968] "Bcl-Xs_Adenovirus_Vaccine"                                                                                                                                            
[27969] "Belladona_Phenobarbital_Ergotamine"                                                                                                                                   
[27970] "Benazepril_Hydrochloride"                                                                                                                                             
[27971] "Benzonatate"                                                                                                                                                          
[27972] "Benztropine_Mesylate"                                                                                                                                                 
[27973] "Benzylpenicillin_Sodium"                                                                                                                                              
[27974] "Bethanechol_Chloride"                                                                                                                                                 
[27975] "Sodium_Bicarbonate-Aspirin-Citric_Acid"                                                                                                                               
[27976] "Biotene_Mouthwash"                                                                                                                                                    
[27977] "Biotope_CD"                                                                                                                                                           
[27978] "Bisacodyl"                                                                                                                                                            
[27979] "Bisoprolol_Fumarate"                                                                                                                                                  
[27980] "Bisoprolol-Fumarate_Hydrochlorothiazide"                                                                                                                              
[27981] "Brimodine"                                                                                                                                                            
[27982] "Bromocryptine"                                                                                                                                                        
[27983] "Bumetanide"                                                                                                                                                           
[27984] "Bupivacaine"                                                                                                                                                          
[27985] "CAP-2_CEA_Peptide_9-mer"                                                                                                                                              
[27986] "CAP-3_CEA_Peptide_9-Mer"                                                                                                                                              
[27987] "Carbestrol"                                                                                                                                                           
[27988] "CC49-218_sFv"                                                                                                                                                         
[27989] "Cesalin"                                                                                                                                                              
[27990] "CH-296_Fibronectin"                                                                                                                                                   
[27991] "Chelate_Monoclonal_Antibody_B72_3"                                                                                                                                    
[27992] "Chimeric_Antibody_CHCC49"                                                                                                                                             
[27993] "Chimeric_Monoclonal_Antibody_B72_3"                                                                                                                                   
[27994] "Clomesone"                                                                                                                                                            
[27995] "Cyclophosphamide_Mechlorethamine_Prednisone_Procarbazine_Vincristine"                                                                                                 
[27996] "CODP-WAC"                                                                                                                                                             
[27997] "Monoclonal_Antibody_COL-1"                                                                                                                                            
[27998] "Cremophor"                                                                                                                                                            
[27999] "CTLA4-Ig"                                                                                                                                                             
[28000] "Cyclodisone"                                                                                                                                                          
[28001] "Calcipotriene"                                                                                                                                                        
[28002] "Calcium_Chloride"                                                                                                                                                     
[28003] "Calcium_Polycarbophil"                                                                                                                                                
[28004] "Candesartan_Cilexetil"                                                                                                                                                
[28005] "Carisoprodol"                                                                                                                                                         
[28006] "Carteolol_Hydrochloride"                                                                                                                                              
[28007] "Carvedilol"                                                                                                                                                           
[28008] "Casanthranol"                                                                                                                                                         
[28009] "Casanthranol_Docusate"                                                                                                                                                
[28010] "Cascara"                                                                                                                                                              
[28011] "Caspofungin"                                                                                                                                                          
[28012] "Cefaclor"                                                                                                                                                             
[28013] "Cefadroxil"                                                                                                                                                           
[28014] "Cefazolin"                                                                                                                                                            
[28015] "Cefdinir"                                                                                                                                                             
[28016] "Cefoxitin_Sodium"                                                                                                                                                     
[28017] "Cefpodoxime"                                                                                                                                                          
[28018] "Cefprozil"                                                                                                                                                            
[28019] "Cefurexine_Axetil"                                                                                                                                                    
[28020] "Cerivastatin_Sodium"                                                                                                                                                  
[28021] "Cetirizine_Hydrochloride"                                                                                                                                             
[28022] "Chloral_Hydrate"                                                                                                                                                      
[28023] "Benzocaines"                                                                                                                                                          
[28024] "Chlorothiazide"                                                                                                                                                       
[28025] "Chlorpheniramine_Maleate"                                                                                                                                             
[28026] "Chlorzoxazone"                                                                                                                                                        
[28027] "Chlorzoxazone_Acetaminophen"                                                                                                                                          
[28028] "Chlotrimazole"                                                                                                                                                        
[28029] "Cholestyramine"                                                                                                                                                       
[28030] "Chromium_Piccolinate"                                                                                                                                                 
[28031] "Citalopram_Hydrobromide"                                                                                                                                              
[28032] "Citrucel"                                                                                                                                                             
[28033] "Clobetasol_Propionate"                                                                                                                                                
[28034] "Clonazepam"                                                                                                                                                           
[28035] "Clozapine"                                                                                                                                                            
[28036] "Colesevelam_Hydrochloride"                                                                                                                                            
[28037] "Colestipol_Hydrochloride"                                                                                                                                             
[28038] "Lamivudine_Zidovudine"                                                                                                                                                
[28039] "Comtrex"                                                                                                                                                              
[28040] "Cortrsyn"                                                                                                                                                             
[28041] "Cosanthranol"                                                                                                                                                         
[28042] "Cranberry"                                                                                                                                                            
[28043] "Cream"                                                                                                                                                                
[28044] "Creatine_Supplement"                                                                                                                                                  
[28045] "Cromolyn_Sodium"                                                                                                                                                      
[28046] "Cyclobenzaprine"                                                                                                                                                      
[28047] "Cyclopentolate_Hydrochloride"                                                                                                                                         
[28048] "Cyproheptadine_Hydrochloride"                                                                                                                                         
[28049] "Cytochlor"                                                                                                                                                            
[28050] "Tetrandrine"                                                                                                                                                          
[28051] "DAB"                                                                                                                                                                  
[28052] "Dacplatinum"                                                                                                                                                          
[28053] "Diamorphine_Hydrochloride"                                                                                                                                            
[28054] "Dichloroallyl_Lawsone"                                                                                                                                                
[28055] "Diluent_12"                                                                                                                                                           
[28056] "Diluent_for_BCG-Tice"                                                                                                                                                 
[28057] "Diluent_for_Hepsulfam"                                                                                                                                                
[28058] "Anti-Dopamine-b-Hydroxylase_Monoclonal_Antibody-Saporin"                                                                                                              
[28059] "Dacarbazine_Mesna"                                                                                                                                                    
[28060] "Deodorized_Tincture_of_Opium"                                                                                                                                         
[28061] "Dtpace"                                                                                                                                                               
[28062] "Dakins_Solution"                                                                                                                                                      
[28063] "Danaparoid_Sodium"                                                                                                                                                    
[28064] "Dayquil"                                                                                                                                                              
[28065] "Delavirdine_Mesylate"                                                                                                                                                 
[28066] "Demeclocycline_Hydrochloride"                                                                                                                                         
[28067] "Dendritic_Cell_Therapy"                                                                                                                                               
[28068] "Deniluekin"                                                                                                                                                           
[28069] "Deoxythioguanosine"                                                                                                                                                   
[28070] "Desipramine_Hydrochloride"                                                                                                                                            
[28071] "Devils_Foot-Jambul"                                                                                                                                                   
[28072] "Dextroamphetamine"                                                                                                                                                    
[28073] "Diazepam"                                                                                                                                                             
[28074] "Dibromannitol"                                                                                                                                                        
[28075] "Dibucaine"                                                                                                                                                            
[28076] "Diclofenac"                                                                                                                                                           
[28077] "Dicloxacillin"                                                                                                                                                        
[28078] "Dicyclomine_Hydrochloride"                                                                                                                                            
[28079] "Adapalene"                                                                                                                                                            
[28080] "Digoxin"                                                                                                                                                              
[28081] "Diluent_for_161-180_ESO-1_Peptide"                                                                                                                                    
[28082] "Dimenhydrinate"                                                                                                                                                       
[28083] "Dimetapp"                                                                                                                                                             
[28084] "Diphencyprone"                                                                                                                                                        
[28085] "Diphenoxylate"                                                                                                                                                        
[28086] "Divalproex"                                                                                                                                                           
[28087] "Dobutamine_Hydrochloride"                                                                                                                                             
[28088] "Docetaxel_flavopiradol"                                                                                                                                               
[28089] "Docusate_Calcium"                                                                                                                                                     
[28090] "Docusate_Sodium"                                                                                                                                                      
[28091] "Domeboro_Solution"                                                                                                                                                    
[28092] "Donnatol"                                                                                                                                                             
[28093] "Dorzolamide"                                                                                                                                                          
[28094] "Dorzolamide_Sodium"                                                                                                                                                   
[28095] "Doxazosin_Mesylate"                                                                                                                                                   
[28096] "Doxepin_Hydrochloride"                                                                                                                                                
[28097] "Doxycline_Hyclate"                                                                                                                                                    
[28098] "Doxycycline_Calcium"                                                                                                                                                  
[28099] "Doxycycline_Chloride"                                                                                                                                                 
[28100] "Doxycycline_Hydrochloride"                                                                                                                                            
[28101] "Doxycycline_Monohydrate"                                                                                                                                              
[28102] "Drops"                                                                                                                                                                
[28103] "DuraVent_DA"                                                                                                                                                          
[28104] "Duratec"                                                                                                                                                              
[28105] "Dyclonine"                                                                                                                                                            
[28106] "EGFRvIII_Peptide"                                                                                                                                                     
[28107] "Emetine_Hydrochloride"                                                                                                                                                
[28108] "Emfolin_Sodium"                                                                                                                                                       
[28109] "EQUILIN"                                                                                                                                                              
[28110] "Ethidium_Chloride"                                                                                                                                                    
[28111] "Etiocholanolone"                                                                                                                                                      
[28112] "EWS-FLI1_Type_4"                                                                                                                                                      
[28113] "EWS-FLI1_Type_8"                                                                                                                                                      
[28114] "Echinacea"                                                                                                                                                            
[28115] "Efavirenz"                                                                                                                                                            
[28116] "Entex"                                                                                                                                                                
[28117] "Ergocalciferol"                                                                                                                                                       
[28118] "Small_Inducible_Cytokine-B13"                                                                                                                                         
[28119] "Small_Inducible_Cytokine-B14"                                                                                                                                         
[28120] "Esomeprazole_Magnesium"                                                                                                                                               
[28121] "Ethambutol_Hydrochloride"                                                                                                                                             
[28122] "Ethinyl_Estradiol-Levonorgestrel"                                                                                                                                     
[28123] "Ethinyl_Estradiol-Norethindrone"                                                                                                                                      
[28124] "Etretinate"                                                                                                                                                           
[28125] "Ex-Lax"                                                                                                                                                               
[28126] "Excedrin"                                                                                                                                                             
[28127] "FDG"                                                                                                                                                                  
[28128] "FGF-5_172-176_217-220_Peptide"                                                                                                                                        
[28129] "Fluorodopan"                                                                                                                                                          
[28130] "Fluorotestosterone"                                                                                                                                                   
[28131] "Famciclovir"                                                                                                                                                          
[28132] "Famotidine"                                                                                                                                                           
[28133] "Felodipine"                                                                                                                                                           
[28134] "Fenofibrate"                                                                                                                                                          
[28135] "Ferrous_Gluconate"                                                                                                                                                    
[28136] "Ferrous_Sulfate"                                                                                                                                                      
[28137] "Fexofenadine_Hydrochloride"                                                                                                                                           
[28138] "Fioricet"                                                                                                                                                             
[28139] "Fleets_Phospho-Soda"                                                                                                                                                  
[28140] "Flucinolone"                                                                                                                                                          
[28141] "Flunisolide"                                                                                                                                                          
[28142] "Fluocinolone_Acetonide"                                                                                                                                               
[28143] "Fluocinonide"                                                                                                                                                         
[28144] "Fluorometholone"                                                                                                                                                      
[28145] "Fluoxamine"                                                                                                                                                           
[28146] "Flurazepam"                                                                                                                                                           
[28147] "Fluticasone_Propionate"                                                                                                                                               
[28148] "Fluvastatin_Sodium"                                                                                                                                                   
[28149] "Fluvoxamine_Maleate"                                                                                                                                                  
[28150] "FrSh61_MEA_VHL33"                                                                                                                                                     
[28151] "Gamma_Interferon-SCH"                                                                                                                                                 
[28152] "GM-CSF_DNA"                                                                                                                                                           
[28153] "gp100_Vaccinia_Vaccine"                                                                                                                                               
[28154] "Garlic_Extract"                                                                                                                                                       
[28155] "Gatifloxacin"                                                                                                                                                         
[28156] "Gemfibrozil"                                                                                                                                                          
[28157] "Gingkgo"                                                                                                                                                              
[28158] "Glimepiride"                                                                                                                                                          
[28159] "Glipizide"                                                                                                                                                            
[28160] "Glucosamine_Sulfate"                                                                                                                                                  
[28161] "Glyburide"                                                                                                                                                            
[28162] "Glycerin"                                                                                                                                                             
[28163] "Glycopyrrolate"                                                                                                                                                       
[28164] "Glyoktyl"                                                                                                                                                             
[28165] "GoLYTELY"                                                                                                                                                             
[28166] "Guaifenesin"                                                                                                                                                          
[28167] "Guaifenesin_Codeine"                                                                                                                                                  
[28168] "Guaifenisin-DM"                                                                                                                                                       
[28169] "Guaifenisin_Pseudoephedrine"                                                                                                                                          
[28170] "HIV_Peptide_Vaccine"                                                                                                                                                  
[28171] "HIVgP160_Vaccine"                                                                                                                                                     
[28172] "HPV_16_L1-VLP"                                                                                                                                                        
[28173] "Human_MOAB_LICO_28a32"                                                                                                                                                
[28174] "Hepatitis_A_Vaccine"                                                                                                                                                  
[28175] "Hepatitis_B_Vaccine"                                                                                                                                                  
[28176] "Hexylresorcinol"                                                                                                                                                      
[28177] "Homatropine_Hydrobromide"                                                                                                                                             
[28178] "HuCC49deltaCH2-PA-DOTA"                                                                                                                                               
[28179] "Hycaptmn"                                                                                                                                                             
[28180] "Hydrazine"                                                                                                                                                            
[28181] "Hydrochlorothiazide"                                                                                                                                                  
[28182] "Hydrocodone"                                                                                                                                                          
[28183] "Hydrocodone_Acetaminophen"                                                                                                                                            
[28184] "Hydroxychloroquine_Sulfate"                                                                                                                                           
[28185] "Hydroxypropyl_Methycellulose_D"                                                                                                                                       
[28186] "Hydroxyzine"                                                                                                                                                          
[28187] "Hyoscyamine"                                                                                                                                                          
[28188] "Hypoxanthine"                                                                                                                                                         
[28189] "I131-COL1"                                                                                                                                                            
[28190] "IV_Fluid"                                                                                                                                                             
[28191] "Id_Lymph_Skin_Test_Vaccine"                                                                                                                                           
[28192] "Id_MM_Skin_Test_Vaccine"                                                                                                                                              
[28193] "Interleukin-2_Anti-Idiotype_Vaccine"                                                                                                                                  
[28194] "Imexon"                                                                                                                                                               
[28195] "Imipramine"                                                                                                                                                           
[28196] "Immutol"                                                                                                                                                              
[28197] "Indapamide"                                                                                                                                                           
[28198] "Influenza_Vaccine"                                                                                                                                                    
[28199] "Insulin_70_30"                                                                                                                                                        
[28200] "Lente_Insulin"                                                                                                                                                        
[28201] "Lispo_Insulin"                                                                                                                                                        
[28202] "NPH_Insulin"                                                                                                                                                          
[28203] "Regular_Insulin"                                                                                                                                                      
[28204] "Ultralente_Insulin"                                                                                                                                                   
[28205] "Iodine-131_Human_Serum_Albumin"                                                                                                                                       
[28206] "Ipratropium_Bromide"                                                                                                                                                  
[28207] "Ipratropium_Albuterol"                                                                                                                                                
[28208] "Irbesartan"                                                                                                                                                           
[28209] "Irritumomab_tiuxetan"                                                                                                                                                 
[28210] "Isoproterenol"                                                                                                                                                        
[28211] "Isosorbide_Dinitrate"                                                                                                                                                 
[28212] "K-RAS_ASP-12_Mutant_Protein"                                                                                                                                          
[28213] "K-RAS_ASP-13_Mutant_Protein"                                                                                                                                          
[28214] "K-RAS_GLY-12_Mutant_Protein"                                                                                                                                          
[28215] "K-RAS_VAL-12_Mutant_Protein"                                                                                                                                          
[28216] "Hydroxypropylcellulose"                                                                                                                                               
[28217] "KNI-272"                                                                                                                                                              
[28218] "KRAS_CYS-12_Mutant_Protein"                                                                                                                                           
[28219] "Ketamine_Hydrochloride"                                                                                                                                               
[28220] "Lactobutyrin"                                                                                                                                                         
[28221] "Labetalol"                                                                                                                                                            
[28222] "Lactase_Enzyme"                                                                                                                                                       
[28223] "Lactulose"                                                                                                                                                            
[28224] "Laetrille"                                                                                                                                                            
[28225] "Lansoprazole"                                                                                                                                                         
[28226] "Latanoprost"                                                                                                                                                          
[28227] "Levarterenol_Bitartrate"                                                                                                                                              
[28228] "Levobunolol"                                                                                                                                                          
[28229] "Liboxin"                                                                                                                                                              
[28230] "Lidobenalox"                                                                                                                                                          
[28231] "Lidobenalox_Solution"                                                                                                                                                 
[28232] "Linezolid"                                                                                                                                                            
[28233] "Lisinopril"                                                                                                                                                           
[28234] "Lodoxamide_Tromethamide"                                                                                                                                              
[28235] "Lomotrex"                                                                                                                                                             
[28236] "Loratadine"                                                                                                                                                           
[28237] "Loratadine_Pseudoephedrine"                                                                                                                                           
[28238] "Lorcet"                                                                                                                                                               
[28239] "Losartan_Potassium"                                                                                                                                                   
[28240] "Losartan_Hydrochlorothiazide"                                                                                                                                         
[28241] "Lotion"                                                                                                                                                               
[28242] "Amlodipine_Besylate_Benazepril_Hydrochloride"                                                                                                                         
[28243] "Lubriderm"                                                                                                                                                            
[28244] "Lubrin"                                                                                                                                                               
[28245] "Lysine"                                                                                                                                                               
[28246] "M_A_131I_Osteogenic_Sarcoma"                                                                                                                                          
[28247] "M_A_B72_3_CEL"                                                                                                                                                        
[28248] "Monoclonal_Antibody_hB72_3"                                                                                                                                           
[28249] "Monoclonal_Antibody_B72_3F"                                                                                                                                           
[28250] "Monoclonal_Antibody_hLEU_2A"                                                                                                                                          
[28251] "M_A_Idiotypic_Determinants"                                                                                                                                           
[28252] "Melanoma_Monoclonal_Antibody_hIgG2A"                                                                                                                                  
[28253] "M_A_Radiolabeled_Anti-BRST_Cancer"                                                                                                                                    
[28254] "M_A_Radiolabeled_Anti-Carcinoma"                                                                                                                                      
[28255] "M_A_Radiolabeled_T101_Human_T-LYMP"                                                                                                                                   
[28256] "M_A_T101_HUMAN_T-LYMPHOCYTE"                                                                                                                                          
[28257] "M_A_TAC_Conjugated_Pseudomonas_EXO"                                                                                                                                   
[28258] "M-BADOC"                                                                                                                                                              
[28259] "MAGE-1_VACCINIA_CONTAM_BVDV"                                                                                                                                          
[28260] "MAGE-3_Peptide_Amino_acid_sequence_FLWGPRALV_plus_H22806"                                                                                                             
[28261] "MELENGESTEROL"                                                                                                                                                        
[28262] "Retroviral_Vector_MFGS-MOv18-gamma"                                                                                                                                   
[28263] "Michellamine_B"                                                                                                                                                       
[28264] "MITINDOMIDE"                                                                                                                                                          
[28265] "Monoclonal_Antibody_1_4"                                                                                                                                              
[28266] "Monoclonal_Antibody_1_4_F_ab"                                                                                                                                         
[28267] "Monoclonal_Antibody_1F5"                                                                                                                                              
[28268] "Monoclonal_Antibody_48_7"                                                                                                                                             
[28269] "Monoclonal_Antibody_48_7_F_ab"                                                                                                                                        
[28270] "Monoclonal_Antibody_528"                                                                                                                                              
[28271] "Monoclonal_Antibody_8_2"                                                                                                                                              
[28272] "Monoclonal_Antibody_8_2_F_ab"                                                                                                                                         
[28273] "Monoclonal_Antibody_9_2_27_F_ab"                                                                                                                                      
[28274] "Monoclonal_Antibody_96_5"                                                                                                                                             
[28275] "Monoclonal_Antibody_96_5_F_ab"                                                                                                                                        
[28276] "MOAB_B-3-CHX-A-DTPA"                                                                                                                                                  
[28277] "Monoclonal_Antibody_B6_2_F_ab"                                                                                                                                        
[28278] "Monoclonal_Antibody_B6_2F_ab_2"                                                                                                                                       
[28279] "Monoclonal_Antibody_BL-3"                                                                                                                                             
[28280] "MOAB_BOMBESIN_2A11"                                                                                                                                                   
[28281] "MOAB_BOMBESIN_DTPA"                                                                                                                                                   
[28282] "MOAB_BOMBESIN_ITC-D"                                                                                                                                                  
[28283] "Monoclonal_Antibody_CC-83"                                                                                                                                            
[28284] "Monoclonal_Antibody_CC-92"                                                                                                                                            
[28285] "Monoclonal_Antibody_CEM-231"                                                                                                                                          
[28286] "Monoclonal_Antibody_COL-6"                                                                                                                                            
[28287] "Monoclonal_Antibody_45-2D9"                                                                                                                                           
[28288] "MOAB_Colorectal_Carcinoma"                                                                                                                                            
[28289] "Monoclonal_Antibody_HD37-SMPT-dgA_Immunotoxin"                                                                                                                        
[28290] "Monoclonal_Antibody_BL3-GD_Idiotypic_Determinant"                                                                                                                     
[28291] "Monoclonal_Antibody_IMMU-14"                                                                                                                                          
[28292] "Monoclonal_Antibody_LYM-2"                                                                                                                                            
[28293] "Monoclonal_Antibody_N901-bR"                                                                                                                                          
[28294] "Monoclonal_Antibody_NR-CO-04"                                                                                                                                         
[28295] "Monoclonal_Antibody_OVB3-PE"                                                                                                                                          
[28296] "Monoclonal_Antibody_RG_83852"                                                                                                                                         
[28297] "In_111_Monoclonal_Antibody_Anti-TAC"                                                                                                                                  
[28298] "MOv-gamma"                                                                                                                                                            
[28299] "MSM_Glucosamine"                                                                                                                                                      
[28300] "Mouse_Monoclonal_Antibody_LYM-1"                                                                                                                                      
[28301] "Murine_Monoclonal_Antibody_D612"                                                                                                                                      
[28302] "Magic_Mouthwash"                                                                                                                                                      
[28303] "Magnesium"                                                                                                                                                            
[28304] "Magnesium_Chloride"                                                                                                                                                   
[28305] "Magnesium_Citrate"                                                                                                                                                    
[28306] "Magnesium_Oxide"                                                                                                                                                      
[28307] "Choline_Magnesium_Trisalicylate"                                                                                                                                      
[28308] "Meclizine_Hydrochloride"                                                                                                                                              
[28309] "Meglumine_Amidotrizoate"                                                                                                                                              
[28310] "Meropenum"                                                                                                                                                            
[28311] "Mesalamine"                                                                                                                                                           
[28312] "Psyllium_Husk"                                                                                                                                                        
[28313] "Metformin_Hydrochloride"                                                                                                                                              
[28314] "Methocarbamol"                                                                                                                                                        
[28315] "Methylcellulose"                                                                                                                                                      
[28316] "Metoprolol_Succinate"                                                                                                                                                 
[28317] "Metoprolol_Tartrate"                                                                                                                                                  
[28318] "Micellar_Paclitaxel"                                                                                                                                                  
[28319] "Miconazole"                                                                                                                                                           
[28320] "Pyrilamine_Caffeine_Acetaminophen"                                                                                                                                    
[28321] "Pyrilamine_Pamabrom_Acetaminophen"                                                                                                                                    
[28322] "Isometheptane_Dichloralphenazone_Acetaminophen"                                                                                                                       
[28323] "Milk_Thistle"                                                                                                                                                         
[28324] "Milk_of_Magnesium"                                                                                                                                                    
[28325] "Milrinone_Lactate"                                                                                                                                                    
[28326] "Mineral_Oil"                                                                                                                                                          
[28327] "Mirtazapine"                                                                                                                                                          
[28328] "Mivopenim"                                                                                                                                                            
[28329] "Moexipril_Hydrochloride"                                                                                                                                              
[28330] "Mometasone_Furoate"                                                                                                                                                   
[28331] "Mouthwash"                                                                                                                                                            
[28332] "Multivitamins_Minerals"                                                                                                                                               
[28333] "Mupirocin"                                                                                                                                                            
[28334] "Mycophenolate"                                                                                                                                                        
[28335] "Mylanta"                                                                                                                                                              
[28336] "N_N-Dimethylacetamide"                                                                                                                                                
[28337] "NA17_Peptide_Amino_acid_sequence_VLPDVFIRCV"                                                                                                                          
[28338] "Nevirapine"                                                                                                                                                           
[28339] "Nitroestron_Meth_ETH"                                                                                                                                                 
[28340] "Nandrolone"                                                                                                                                                           
[28341] "Nadolol"                                                                                                                                                              
[28342] "Nafcillin"                                                                                                                                                            
[28343] "Nature_s_Remedy"                                                                                                                                                      
[28344] "Nefazadone_Hydrochloride"                                                                                                                                             
[28345] "Nefludan"                                                                                                                                                             
[28346] "Nelfinavir"                                                                                                                                                           
[28347] "Neosporin_Cream"                                                                                                                                                      
[28348] "Neosporin_Ophthalmic"                                                                                                                                                 
[28349] "Potassium_Phosphate-Sodium_Phosphate"                                                                                                                                 
[28350] "Nifabutin"                                                                                                                                                            
[28351] "Nifedipine"                                                                                                                                                           
[28352] "Nisoldipine"                                                                                                                                                          
[28353] "Nitrofurantoin"                                                                                                                                                       
[28354] "Nitroglycerin"                                                                                                                                                        
[28355] "Nizatidine"                                                                                                                                                           
[28356] "Nyquil"                                                                                                                                                               
[28357] "OXY_104"                                                                                                                                                              
[28358] "Oatmeal_Powder"                                                                                                                                                       
[28359] "Olizumab"                                                                                                                                                             
[28360] "Opium_Tincture"                                                                                                                                                       
[28361] "Ophthalmic_Solution"                                                                                                                                                  
[28362] "Orlistat"                                                                                                                                                             
[28363] "Ethinyl_Estradiol-Norgestimate"                                                                                                                                       
[28364] "Oseltamivir"                                                                                                                                                          
[28365] "Oxandrolone"                                                                                                                                                          
[28366] "Oxaprozin"                                                                                                                                                            
[28367] "Oxybutynin_Cloride"                                                                                                                                                   
[28368] "Oxycodone"                                                                                                                                                            
[28369] "Oxycodone_Acetaminophen"                                                                                                                                              
[28370] "Oxycodone_Rixicodone"                                                                                                                                                 
[28371] "Oxymetazoline_Hydrochloride"                                                                                                                                          
[28372] "Oxymorphone"                                                                                                                                                          
[28373] "P32"                                                                                                                                                                  
[28374] "rFowlpox-CEA_D609_MUC1_L93_TRICOM"                                                                                                                                    
[28375] "rVaccinia-CEA_D609_MUC1_L93_TRICOM"                                                                                                                                   
[28376] "PCLUS_3_18MN_PCLUS_6_1_18MN"                                                                                                                                          
[28377] "Phetharbital"                                                                                                                                                         
[28378] "Phosphate_Buffer"                                                                                                                                                     
[28379] "Phosphoramide_Mustard"                                                                                                                                                
[28380] "Phsap"                                                                                                                                                                
[28381] "Phyllanthoside"                                                                                                                                                       
[28382] "PIXY"                                                                                                                                                                 
[28383] "PNU-214565"                                                                                                                                                           
[28384] "Purified_Protein_Derivative"                                                                                                                                          
[28385] "PR-52"                                                                                                                                                                
[28386] "PR18_ras-12CYS_Peptide"                                                                                                                                               
[28387] "Pregn-4-ene_Trione"                                                                                                                                                   
[28388] "Prospidin"                                                                                                                                                            
[28389] "PROSTVAC-CONTAMINATED_W_BVDV"                                                                                                                                         
[28390] "PS_IL-10"                                                                                                                                                             
[28391] "PS_IL-10_Placebo"                                                                                                                                                     
[28392] "PSA-OP_Peptide_Vaccine"                                                                                                                                               
[28393] "PSA_154-163_155L_PSA-3A"                                                                                                                                              
[28394] "Small_Inducible_Cytokine-B6"                                                                                                                                          
[28395] "PSMA_Peptide"                                                                                                                                                         
[28396] "PT523"                                                                                                                                                                
[28397] "PTF"                                                                                                                                                                  
[28398] "Pyran_Polymer"                                                                                                                                                        
[28399] "Pyrazole_Imidazole"                                                                                                                                                   
[28400] "Pancrelipase"                                                                                                                                                         
[28401] "Pantoprazole"                                                                                                                                                         
[28402] "Pegfilgrastim_Neulasta"                                                                                                                                               
[28403] "Pentamidine_Isethionate"                                                                                                                                              
[28404] "Pentosan"                                                                                                                                                             
[28405] "Percocet"                                                                                                                                                             
[28406] "Peri-Colace"                                                                                                                                                          
[28407] "Peripheral_Stem_Cell_Transplant"                                                                                                                                      
[28408] "Permethrin"                                                                                                                                                           
[28409] "Perphenazine"                                                                                                                                                         
[28410] "Petrolatum_Hydrophilic"                                                                                                                                               
[28411] "Phenazopyridine"                                                                                                                                                      
[28412] "Pheniramine_Maleate"                                                                                                                                                  
[28413] "Phenolphthalein"                                                                                                                                                      
[28414] "Phenoxymethylpenicillin"                                                                                                                                              
[28415] "Phentermine_Hydrochloride"                                                                                                                                            
[28416] "Phenylephedrine_Phenylpropanolamine_Guaifenesin"                                                                                                                      
[28417] "Phenylephrine"                                                                                                                                                        
[28418] "Phenylpropanolamine"                                                                                                                                                  
[28419] "Phytonadione"                                                                                                                                                         
[28420] "Pimonidazole_Hydrochloride"                                                                                                                                           
[28421] "Pioglitazone"                                                                                                                                                         
[28422] "Podofilox"                                                                                                                                                            
[28423] "Polycitra"                                                                                                                                                            
[28424] "Polyvinyl_Alcohol"                                                                                                                                                    
[28425] "Polyvinyl_Alcohol_PVA"                                                                                                                                                
[28426] "Potassium_Citrate"                                                                                                                                                    
[28427] "Potassium_Phosphate"                                                                                                                                                  
[28428] "Pramipexole_Dihydrochloride"                                                                                                                                          
[28429] "Pravastatin"                                                                                                                                                          
[28430] "Etoposide_Prednisone"                                                                                                                                                 
[28431] "Prempro"                                                                                                                                                              
[28432] "Preparation_H"                                                                                                                                                        
[28433] "Probenecid_Colchicine"                                                                                                                                                
[28434] "Proctofoam"                                                                                                                                                           
[28435] "Propranolol_Hydrochloride"                                                                                                                                            
[28436] "Propantheline_Bromide"                                                                                                                                                
[28437] "Propofol"                                                                                                                                                             
[28438] "Propoxyphene_Hydrochloride"                                                                                                                                           
[28439] "Propoxyphene_Napsylate"                                                                                                                                               
[28440] "Propoxyphene_Napsylate-Acetaminophen"                                                                                                                                 
[28441] "Propylene_Glycol"                                                                                                                                                     
[28442] "Propyllin_CCC"                                                                                                                                                        
[28443] "Pseudoephedrine_Hydrochloride"                                                                                                                                        
[28444] "Pseudophedrine_Sulfate"                                                                                                                                               
[28445] "Pseudophedrine_Loratadine"                                                                                                                                            
[28446] "Psyllium"                                                                                                                                                             
[28447] "Pyazoloacidine"                                                                                                                                                       
[28448] "Pyrazinamide"                                                                                                                                                         
[28449] "Pyrazole"                                                                                                                                                             
[28450] "Quinapril"                                                                                                                                                            
[28451] "Quinine_Sulfate"                                                                                                                                                      
[28452] "Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Vincristine_R-Verapamil"                                                                                            
[28453] "RASVAC-C"                                                                                                                                                             
[28454] "RASVAC-V"                                                                                                                                                             
[28455] "RH1"                                                                                                                                                                  
[28456] "Rhizoxin_Diluent"                                                                                                                                                     
[28457] "Rifamycin"                                                                                                                                                            
[28458] "RTGF-Beta"                                                                                                                                                            
[28459] "RV-B7_RECOMB_VACCINIA_B7"                                                                                                                                             
[28460] "Recombinant_Vaccinia-MUC-1_B7"                                                                                                                                        
[28461] "Rabeprazole"                                                                                                                                                          
[28462] "Ramipril"                                                                                                                                                             
[28463] "Ranitidine"                                                                                                                                                           
[28464] "Refresh_PM_Lubricant"                                                                                                                                                 
[28465] "Replens"                                                                                                                                                              
[28466] "Murine_MCA_Ricin_Conjugate"                                                                                                                                           
[28467] "Risperidone"                                                                                                                                                          
[28468] "Sangivamycin_Hydrochloride"                                                                                                                                           
[28469] "SBIL-2"                                                                                                                                                               
[28470] "SCAB"                                                                                                                                                                 
[28471] "Shared_Anti-Idiotype-AB-S002"                                                                                                                                         
[28472] "Shared_Anti-Idiotype-AB-S003"                                                                                                                                         
[28473] "Shared_Anti-Idiotype-AB-S004"                                                                                                                                         
[28474] "Shared_Anti-Idiotype-AB-S005"                                                                                                                                         
[28475] "Shared_Anti-Idiotype-AB-S006"                                                                                                                                         
[28476] "Shared_Anti-Idiotype-AB-S008A"                                                                                                                                        
[28477] "Shared_Anti-Idiotype-AB-S011A"                                                                                                                                        
[28478] "Shared_Anti-Idiotype-AB-S012"                                                                                                                                         
[28479] "Shared_Anti-Idiotype-AB-S016"                                                                                                                                         
[28480] "Shared_Anti-Idiotpe-AB-S017"                                                                                                                                          
[28481] "Shared_Anti-Idiotype-AB-S018"                                                                                                                                         
[28482] "Shared_Anti-Idiotype-AB-S021A"                                                                                                                                        
[28483] "Shared_Anti-Idiotype-AB-S024A"                                                                                                                                        
[28484] "Shared_Anti-Idiotype-AB-S025"                                                                                                                                         
[28485] "Shared_Anti-Idiotype-AB-S027"                                                                                                                                         
[28486] "SJG-136"                                                                                                                                                              
[28487] "SPI-77"                                                                                                                                                               
[28488] "SS1_dsFv_PE38"                                                                                                                                                        
[28489] "STAMP"                                                                                                                                                                
[28490] "Steroid_Suspending_Vehicle"                                                                                                                                           
[28491] "Stilbene_Aldehyde"                                                                                                                                                    
[28492] "Salicylic_Acid-Sulfur"                                                                                                                                                
[28493] "Salivart"                                                                                                                                                             
[28494] "Salmeterol"                                                                                                                                                           
[28495] "Saquinavir"                                                                                                                                                           
[28496] "Sarna"                                                                                                                                                                
[28497] "Scopolamine_Hydrobromide"                                                                                                                                             
[28498] "Senna_Fruit"                                                                                                                                                          
[28499] "Sennosides"                                                                                                                                                           
[28500] "Senokot"                                                                                                                                                              
[28501] "Senokot-S"                                                                                                                                                            
[28502] "Sertraline_Hydrochloride"                                                                                                                                             
[28503] "Silenafil_Citrate"                                                                                                                                                    
[28504] "Simethicone"                                                                                                                                                          
[28505] "Simvastatin"                                                                                                                                                          
[28506] "Sinucleanse_Kit"                                                                                                                                                      
[28507] "Skelex"                                                                                                                                                               
[28508] "Sodium_Bicarbonate"                                                                                                                                                   
[28509] "Sodium_Cromoglycate"                                                                                                                                                  
[28510] "Sodium_Phosphorus"                                                                                                                                                    
[28511] "Sodium_Polystrene"                                                                                                                                                    
[28512] "Sodium_Polystyrene_Sulfonate"                                                                                                                                         
[28513] "Sorbitol"                                                                                                                                                             
[28514] "Sotalol_Hydrochloride"                                                                                                                                                
[28515] "StudyMed_00C0080"                                                                                                                                                     
[28516] "StudyMed_98C0118"                                                                                                                                                     
[28517] "Succinylated_Dimer_Form_of"                                                                                                                                           
[28518] "Sulfacetamide"                                                                                                                                                        
[28519] "Sulfadiazine"                                                                                                                                                         
[28520] "Sulfasalazine"                                                                                                                                                        
[28521] "Sumatriptan_Succinate"                                                                                                                                                
[28522] "Aminoglutethimide_Hydrocortisone_Suramin"                                                                                                                             
[28523] "Flutamide_Hydrocortisone_Suramin"                                                                                                                                     
[28524] "Swiss_Kiss"                                                                                                                                                           
[28525] "Synerlip_p53"                                                                                                                                                         
[28526] "TAS-106"                                                                                                                                                              
[28527] "TBC-CEA_Contaminated_w_BVDV"                                                                                                                                          
[28528] "THYMOSIN_FRACTION_5"                                                                                                                                                  
[28529] "Tumor_Infiltrating_Lymphocytes-N2-Transduced"                                                                                                                         
[28530] "TIL_TRANSDUCED_GENE_CODING_FOR_TNF"                                                                                                                                   
[28531] "Cisplatin_Dacarbazine_Interferon-alpha_Tamoxifen_Tumor-Infiltrating-Lymphocytes"                                                                                      
[28532] "Monoclonal_Antibody_T101_F_AB_2"                                                                                                                                      
[28533] "TNF_Transduced_TIL"                                                                                                                                                   
[28534] "TP-38"                                                                                                                                                                
[28535] "TPN"                                                                                                                                                                  
[28536] "Trimelamole"                                                                                                                                                          
[28537] "Tamsulosin_Hydrochloride"                                                                                                                                             
[28538] "Tazarotene"                                                                                                                                                           
[28539] "Temezepam"                                                                                                                                                            
[28540] "Tenecteplase"                                                                                                                                                         
[28541] "Tenofovir"                                                                                                                                                            
[28542] "Terazosin_Hydrochloride"                                                                                                                                              
[28543] "Terbinafine_Hydrochloride"                                                                                                                                            
[28544] "Terconzole"                                                                                                                                                           
[28545] "Terfenadine"                                                                                                                                                          
[28546] "Theraflu"                                                                                                                                                             
[28547] "Thiethylperazine"                                                                                                                                                     
[28548] "Thioridazine_Hydrochloride"                                                                                                                                           
[28549] "Thrombin"                                                                                                                                                             
[28550] "Tioconazole"                                                                                                                                                          
[28551] "Timolol_Maleate"                                                                                                                                                      
[28552] "Tolazamide"                                                                                                                                                           
[28553] "Tolmetin"                                                                                                                                                             
[28554] "Tolterodine"                                                                                                                                                          
[28555] "Topical_Corticosteroids"                                                                                                                                              
[28556] "Torsemide"                                                                                                                                                            
[28557] "Tramadol"                                                                                                                                                             
[28558] "Tramadol_Hydrochloride"                                                                                                                                               
[28559] "Trastuzamab_Gemcitabine"                                                                                                                                              
[28560] "Trazadone"                                                                                                                                                            
[28561] "TriGem"                                                                                                                                                               
[28562] "Triaminic_AM_Cough_and_Decongestant"                                                                                                                                  
[28563] "Triaminic_AM_Decongestant"                                                                                                                                            
[28564] "Triaminic_Cold"                                                                                                                                                       
[28565] "Triaminic_Cold_and_Allergy"                                                                                                                                           
[28566] "Triaminic_DM_Syrup"                                                                                                                                                   
[28567] "Triaminic_Night_Time"                                                                                                                                                 
[28568] "Triaminic_Syrup"                                                                                                                                                      
[28569] "Triamterene"                                                                                                                                                          
[28570] "Triazolam"                                                                                                                                                            
[28571] "Trilisate"                                                                                                                                                            
[28572] "Trimethobenzamide_Hydrochloride"                                                                                                                                      
[28573] "Triptorelin_Pamoate"                                                                                                                                                  
[28574] "Trisalicylate"                                                                                                                                                        
[28575] "Tucks"                                                                                                                                                                
[28576] "Tylenol_Sinus"                                                                                                                                                        
[28577] "U-90"                                                                                                                                                                 
[28578] "Uniroyal_Compound"                                                                                                                                                    
[28579] "UVB"                                                                                                                                                                  
[28580] "Undecyclenic_Acid"                                                                                                                                                    
[28581] "Carbamide"                                                                                                                                                            
[28582] "Urised"                                                                                                                                                               
[28583] "VAC0P"                                                                                                                                                                
[28584] "VATH"                                                                                                                                                                 
[28585] "Valacyclovir_Hydrochloride"                                                                                                                                           
[28586] "Valproic_Acid"                                                                                                                                                        
[28587] "Variconazole"                                                                                                                                                         
[28588] "Vaseline"                                                                                                                                                             
[28589] "Enalapril_Maleate-Hydrochlorothiazide"                                                                                                                                
[28590] "Venlafaxine_Hydrochloride"                                                                                                                                            
[28591] "Vicodin"                                                                                                                                                              
[28592] "Etoposide_Prednisone_Vinblastine"                                                                                                                                     
[28593] "Vortex_Mixer"                                                                                                                                                         
[28594] "Warburg_Therapy"                                                                                                                                                      
[28595] "White_Petrolatum-Minerals"                                                                                                                                            
[28596] "Wild_Type_and_Mutant_MGMT_Vector"                                                                                                                                     
[28597] "Zolimomab_Aritox"                                                                                                                                                     
[28598] "Zaleplon"                                                                                                                                                             
[28599] "Zinc_Undecylenate"                                                                                                                                                    
[28600] "Zolpidem_Tartrate"                                                                                                                                                    
[28601] "gp-120_Antigen"                                                                                                                                                       
[28602] "gp100_Protein_184V"                                                                                                                                                   
[28603] "gp100_Peptide-sensitized_Autologous_T-cells_CD4_plus_and_CD8_plus"                                                                                                    
[28604] "rCD4_IgG"                                                                                                                                                             
[28605] "rF-MUC-1_DF3-TRICOM"                                                                                                                                                  
[28606] "rF-PSA_PSMA_TRICOM"                                                                                                                                                   
[28607] "rFowlpox-PSA_L155_TRICOM"                                                                                                                                             
[28608] "rMVA-PSA_PSMA_TRICOM"                                                                                                                                                 
[28609] "Recombinant_Vaccinia-MUC1-B7_1"                                                                                                                                       
[28610] "Recombinant_Vaccinia-PSA_PSMA"                                                                                                                                        
[28611] "Recombinant_Vaccinia-TRP1"                                                                                                                                            
[28612] "rVaccinia-PSA_L155_TRICOM"                                                                                                                                            
[28613] "Recombinant_Vaccinia-gp100p209"                                                                                                                                       
[28614] "y2B8"                                                                                                                                                                 
[28615] "Dual_Specificity_Phosphatase-1"                                                                                                                                       
[28616] "Presynaptic_Protein-SAP97"                                                                                                                                            
[28617] "Presynaptic_Density_Protein-95"                                                                                                                                       
[28618] "TATA-Binding_Protein-Associated_Phosphoprotein"                                                                                                                       
[28619] "DR1-Associated_Protein-1"                                                                                                                                             
[28620] "HLA_Class-II_Histocompatibility_Antigen-DRB"                                                                                                                          
[28621] "Nitric_Oxide_Synthetase_Inhibitor"                                                                                                                                    
[28622] "DNA_Polymerase_Inhibitor"                                                                                                                                             
[28623] "Beta-Adrenergic_Blocking_Agent"                                                                                                                                       
[28624] "Carbonic_Anhydrase_Inhibitor"                                                                                                                                         
[28625] "Histamine-1_Receptor_Antagonist"                                                                                                                                      
[28626] "Thrombospondin_Type-I_Domain-2_Protein"                                                                                                                               
[28627] "Hypothetical_Protein-FLJ20174"                                                                                                                                        
[28628] "Leucine-Rich_Repeat_Transmembrane_Protein_FLRT3"                                                                                                                      
[28629] "FGFR1_Oncogene_Partner"                                                                                                                                               
[28630] "Epithelial_Mesenchymal_Transition_Tumor_of_the_Mouse_Mammary_Gland"                                                                                                   
[28631] "FGF_Receptor_Activating_Protein-1"                                                                                                                                    
[28632] "Proto-Oncogene-FRAT1_Protein"                                                                                                                                         
[28633] "FYN-Related_Kinase"                                                                                                                                                   
[28634] "FGFR_Signalling_Adaptor"                                                                                                                                              
[28635] "FGFR_Substrate-3"                                                                                                                                                     
[28636] "Phenylalanyl-tRNA_Synthetase_Beta-Subunit"                                                                                                                            
[28637] "FUS-1_Protein"                                                                                                                                                        
[28638] "Follicular_Variant_Translocation_Protein-1"                                                                                                                           
[28639] "EPS8-Related_Protein-1"                                                                                                                                               
[28640] "EPS8-Related_Protein-2"                                                                                                                                               
[28641] "Growth-Arrest-Specific_Protein-2"                                                                                                                                     
[28642] "Essential_Amino_Acid"                                                                                                                                                 
[28643] "Non-Essential_Amino_Acid"                                                                                                                                             
[28644] "Histidine"                                                                                                                                                            
[28645] "Isoleucine"                                                                                                                                                           
[28646] "Leucine"                                                                                                                                                              
[28647] "Methionine"                                                                                                                                                           
[28648] "Phenylalanine"                                                                                                                                                        
[28649] "Threonine"                                                                                                                                                            
[28650] "Tryptophan"                                                                                                                                                           
[28651] "Valine"                                                                                                                                                               
[28652] "Alanine"                                                                                                                                                              
[28653] "Arginine"                                                                                                                                                             
[28654] "Asparagine"                                                                                                                                                           
[28655] "Aspartic_Acid"                                                                                                                                                        
[28656] "Cysteine"                                                                                                                                                             
[28657] "Cystine"                                                                                                                                                              
[28658] "Ornithine"                                                                                                                                                            
[28659] "Proline"                                                                                                                                                              
[28660] "Serine"                                                                                                                                                               
[28661] "EPS8-Related_Protein-3"                                                                                                                                               
[28662] "Fatty_Acid-Binding_Protein-1"                                                                                                                                         
[28663] "Fatty_Acid-Binding_Protein-2"                                                                                                                                         
[28664] "Fatty_Acid-Binding_Protein-4"                                                                                                                                         
[28665] "Therapeutic_Androstanolone"                                                                                                                                           
[28666] "Androstanolone"                                                                                                                                                       
[28667] "Geminin"                                                                                                                                                              
[28668] "Glycoprotein-A33"                                                                                                                                                     
[28669] "Metaplasia_of_the_Mouse_Prostate_Gland"                                                                                                                               
[28670] "Well_Differentiated_Invasive_Adenocarcinoma_of_the_Mouse_Prostate_Gland"                                                                                              
[28671] "Combination_Medication"                                                                                                                                               
[28672] "Cough_and_Cold_Preparation"                                                                                                                                           
[28673] "Analgesic_Preparation"                                                                                                                                                
[28674] "Laxative_Preparation"                                                                                                                                                 
[28675] "Antacid_Preparation"                                                                                                                                                  
[28676] "Antirheumatic_Preparation"                                                                                                                                            
[28677] "Asthma_Preparation"                                                                                                                                                   
[28678] "Antihypertensive_Preparation"                                                                                                                                         
[28679] "Anti-infective_Preparation"                                                                                                                                           
[28680] "Electrolyte_Replacement_Preparation"                                                                                                                                  
[28681] "Topical_Preparation"                                                                                                                                                  
[28682] "Oral_Contraceptive_Preparation"                                                                                                                                       
[28683] "G_Protein-Coupled_Receptor-39-1"                                                                                                                                      
[28684] "Sexual_Maturation"                                                                                                                                                    
[28685] "G_Protein-Coupled_Receptor-54-1"                                                                                                                                      
[28686] "pH_Homeostasis"                                                                                                                                                       
[28687] "mRNA_Surveillance"                                                                                                                                                    
[28688] "RNA_Proof-Reading"                                                                                                                                                    
[28689] "Non-Stop_Decay"                                                                                                                                                       
[28690] "Nonsense-Mediated_Decay"                                                                                                                                              
[28691] "Body_Surface"                                                                                                                                                         
[28692] "Signal_Repression"                                                                                                                                                    
[28693] "H19_Imprinted_Maternal_Untranslated_mRNA"                                                                                                                             
[28694] "G_Protein-Coupled_Receptor_39"                                                                                                                                        
[28695] "G_Protein-Coupled_Receptor_54"                                                                                                                                        
[28696] "TFIIA_Alpha-p55"                                                                                                                                                      
[28697] "Transcription_Initiation_Factor-IIA_Alpha_Chain"                                                                                                                      
[28698] "Transcription_Initiation_Factor-IIA_Beta_Chain"                                                                                                                       
[28699] "Transcription_Initiation_Factor-IIA_Gamma_Chain"                                                                                                                      
[28700] "General_Transcription_Factor-TFIIB"                                                                                                                                   
[28701] "Transcription_Initiation_Factor-IIE_Alpha_Subunit"                                                                                                                    
[28702] "Transcription_Initiation_Factor-IIF_Alpha_Subunit"                                                                                                                    
[28703] "Transcription_Initiation_Factor-IIF_Beta_Subunit"                                                                                                                     
[28704] "General_Transcription_Factor-IIH1-62kDa"                                                                                                                              
[28705] "General_Transcription_Factor-IIIC1_Alpha_Subunit"                                                                                                                     
[28706] "General_Transcription_Factor-IIIC2_Beta_Subunit"                                                                                                                      
[28707] "General_Transcription_Factor-IIIC3-102kDa"                                                                                                                            
[28708] "General_Transcription_Factor-IIIC4-90kDa"                                                                                                                             
[28709] "General_Transcription_Factor-IIIC5-63kDa"                                                                                                                             
[28710] "Transcription_Initiation_Factor-IIE_Beta_Subunit"                                                                                                                     
[28711] "Putative_GR6_Protein"                                                                                                                                                 
[28712] "GR6_Protein"                                                                                                                                                          
[28713] "Jumping_Translocation_Breakpoint_Protein"                                                                                                                             
[28714] "Oligonucleotide_Linker"                                                                                                                                               
[28715] "Merphalen"                                                                                                                                                            
[28716] "Skin_Test_Vaccine"                                                                                                                                                    
[28717] "Inactivated_Vaccine"                                                                                                                                                  
[28718] "Yttrium_90_Monoclonal_Antibody_T101"                                                                                                                                  
[28719] "Muscle_Relaxant"                                                                                                                                                      
[28720] "Laxative"                                                                                                                                                             
[28721] "Antispasmotic_Agent"                                                                                                                                                  
[28722] "Stool_Softener"                                                                                                                                                       
[28723] "Astringent"                                                                                                                                                           
[28724] "Anti-ulcer_Agent"                                                                                                                                                     
[28725] "Histamine-2_Receptor_Antagonist"                                                                                                                                      
[28726] "Anti-lipidemic_Agent"                                                                                                                                                 
[28727] "Antimuscarinic_Agent"                                                                                                                                                 
[28728] "Anti-glaucoma_Agent"                                                                                                                                                  
[28729] "Mydriatic_Agent"                                                                                                                                                      
[28730] "Vasodilating_Agent"                                                                                                                                                   
[28731] "Anti-psoriatic_Agent"                                                                                                                                                 
[28732] "Alpha-adrenergic_Agonist"                                                                                                                                             
[28733] "Antipsychotic_Agent"                                                                                                                                                  
[28734] "Anti-diabetic_Agent"                                                                                                                                                  
[28735] "Anti-asthmatic_Agent"                                                                                                                                                 
[28736] "Alpha-adrenergic_Blocking_Agent"                                                                                                                                      
[28737] "Mast_Cell_Stabilizer"                                                                                                                                                 
[28738] "Gastrointestinal_Lipase_Inhibitor"                                                                                                                                    
[28739] "Antihistamine"                                                                                                                                                        
[28740] "DNA_Compaction_Peptide"                                                                                                                                               
[28741] "Smoking_History"                                                                                                                                                      
[28742] "Monoclonal_Antibody_to_Colorectal_Cancer"                                                                                                                             
[28743] "Hypotensive_Agent"                                                                                                                                                    
[28744] "Proton_Pump_Inhibitor"                                                                                                                                                
[28745] "Cyanoglycoside_Agent"                                                                                                                                                 
[28746] "Conjugating_Agent"                                                                                                                                                    
[28747] "Enzyme_Replacement_Preparation"                                                                                                                                       
[28748] "Pediculocide"                                                                                                                                                         
[28749] "Anorexiant"                                                                                                                                                           
[28750] "Alkalinizing_Agent_Preparation"                                                                                                                                       
[28751] "Electrolyte_Replacement_Agent"                                                                                                                                        
[28752] "Hormone_Replacement_Preparation"                                                                                                                                      
[28753] "Antigout_Preparation"                                                                                                                                                 
[28754] "Hemmorrhoidal_Preparation"                                                                                                                                            
[28755] "Stress-Induced_Protein"                                                                                                                                               
[28756] "_11q23_1-q23_3"                                                                                                                                                       
[28757] "Antiflatulent_Agent"                                                                                                                                                  
[28758] "Sulfonamide_Anti-infective_Agent"                                                                                                                                     
[28759] "Interleukin-17C"                                                                                                                                                      
[28760] "Formaldehyde"                                                                                                                                                         
[28761] "Metastin"                                                                                                                                                             
[28762] "Adrenergic_Agent"                                                                                                                                                     
[28763] "Interleukin-1_Receptor-Associated_Kinase-1"                                                                                                                           
[28764] "Interleukin-1_Receptor-Associated_Kinase-2"                                                                                                                           
[28765] "Thrombolytic_Agent"                                                                                                                                                   
[28766] "Interleukin-1_Receptor-Associated_Kinase-3"                                                                                                                           
[28767] "Interleukin-1_Receptor-Associated_Kinase-4"                                                                                                                           
[28768] "IL2-Inducible_T-Cell_Kinase"                                                                                                                                          
[28769] "Inositol-1-4-5-Triphosphate_Receptor_Type-1"                                                                                                                          
[28770] "Sedative_and_Hypnotic"                                                                                                                                                
[28771] "RAD54B_Homolog_Protein"                                                                                                                                               
[28772] "RAS-Related_GTP-Binding_Protein-RAGA"                                                                                                                                 
[28773] "Renal_Tumor_Antigen"                                                                                                                                                  
[28774] "Retinoic_Acid_Induced-3_Protein"                                                                                                                                      
[28775] "RAL_Guanine_Nucleotide_Dissociation_Stimulator"                                                                                                                       
[28776] "RAN_GTPase_Activating_Protein-1"                                                                                                                                      
[28777] "RAS-Related_Protein-RAP1A"                                                                                                                                            
[28778] "Retinoic_Acid_Receptor_Beta"                                                                                                                                          
[28779] "Retinoic_Acid_Receptor_Responder_Protein-3"                                                                                                                           
[28780] "Activator_of_G-Protein_Signaling_1_Protein"                                                                                                                           
[28781] "Expectorant"                                                                                                                                                          
[28782] "_1-Aminobenzo_a_pyrene"                                                                                                                                               
[28783] "Estradiol_Benzoate"                                                                                                                                                   
[28784] "Estradiol_Dipropionate"                                                                                                                                               
[28785] "Horse_Anti-mouse_Anti-lymphocyte_Serum"                                                                                                                               
[28786] "Normal_Horse_Serum"                                                                                                                                                   
[28787] "Pregnant_Mare_Serum_Gonadotropin"                                                                                                                                     
[28788] "Plutonium-239"                                                                                                                                                        
[28789] "Radium-224"                                                                                                                                                           
[28790] "Strontium-90"                                                                                                                                                         
[28791] "Uranium_Ore_Dust"                                                                                                                                                     
[28792] "Adenovirus_5-Fibroblast_Growth_Factor_2"                                                                                                                              
[28793] "_1-Nitrobenzo_a_pyrene"                                                                                                                                               
[28794] "_1-Nitrobenzo_a_pyrene_trans-7_8-Dihydrodiol"                                                                                                                         
[28795] "_1-Nitropyrene"                                                                                                                                                       
[28796] "_19-nor-Progesterone"                                                                                                                                                 
[28797] "Androsterone"                                                                                                                                                         
[28798] "Bovine_Pituitary_Extract"                                                                                                                                             
[28799] "Recombinant_Adenovirus-Cre_Recombinase"                                                                                                                               
[28800] "Recombinant_Adenovirus-LacZ"                                                                                                                                          
[28801] "_1_2-Dimethylhydrazine"                                                                                                                                               
[28802] "_1_2-Dimethylhydrazine_Dihydrochloride"                                                                                                                               
[28803] "_1_2_5_6-Dibenzanthracene"                                                                                                                                            
[28804] "_1_3-Butadiene"                                                                                                                                                       
[28805] "_2-Acetylaminofluorene"                                                                                                                                               
[28806] "_2-Amino-1-Methyl-6-Phenylimidazo_4_5-b_pyridine"                                                                                                                     
[28807] "_2-Amino-3_4-Dimethylimidazole_4_5-f_quinoline"                                                                                                                       
[28808] "_2-Fluoroadenine"                                                                                                                                                     
[28809] "_20-Methylcholanthrene"                                                                                                                                               
[28810] "_2_6-Diaminopurine"                                                                                                                                                   
[28811] "_3-Aminobenzo_a_pyrene"                                                                                                                                               
[28812] "_3-Nitrobenzo_a_pyrene"                                                                                                                                               
[28813] "_3-Nitrobenzo_a_pyrene_trans-7_8-Dihydrodiol"                                                                                                                         
[28814] "_3_4-Benzpyrene"                                                                                                                                                      
[28815] "_4-Methylnitrosamino_1-3-Pyridyl_1-Butanone"                                                                                                                          
[28816] "_4-Nitroquinoline_N-oxide"                                                                                                                                            
[28817] "_4-o-Tolylazo-o-Toluidine"                                                                                                                                            
[28818] "_5-Methylchrysene"                                                                                                                                                    
[28819] "_6-Nitrochrysene"                                                                                                                                                     
[28820] "_9_10-Dimethyl-1_2-Benzanthracene"                                                                                                                                    
[28821] "Acetone"                                                                                                                                                              
[28822] "Benzo_a_pyrene"                                                                                                                                                       
[28823] "Benzo_a_pyrene_trans-7_8-Dihydrodiol"                                                                                                                                 
[28824] "Benzo_b_fluoranthene"                                                                                                                                                 
[28825] "Benzotrichloride"                                                                                                                                                     
[28826] "Beta-Naphthoflavone"                                                                                                                                                  
[28827] "Carbon_Disulfide"                                                                                                                                                     
[28828] "Chlordane"                                                                                                                                                            
[28829] "Chloroform"                                                                                                                                                           
[28830] "Crocidolite_Asbestos"                                                                                                                                                 
[28831] "Croton_Oil"                                                                                                                                                           
[28832] "Cyclopenta_cd_pyrene"                                                                                                                                                 
[28833] "Ether"                                                                                                                                                                
[28834] "Ethyl_Methanesulfonate"                                                                                                                                               
[28835] "Ethylene_Oxide"                                                                                                                                                       
[28836] "Ferric-Nitrilotriacetate"                                                                                                                                             
[28837] "Hydroquinone"                                                                                                                                                         
[28838] "Isoprene"                                                                                                                                                             
[28839] "N-Amyl-N-Methylnitrosoamine"                                                                                                                                          
[28840] "N-butyl-N-4-hydroxybutyl_nitrosamine"                                                                                                                                 
[28841] "N-Nitrosodiethylamine"                                                                                                                                                
[28842] "N-ethyl-N_nitro-N-nitrosoguanidine"                                                                                                                                   
[28843] "N-nitroso-N-methylurethane"                                                                                                                                           
[28844] "Retinoblastoma_Binding_Protein-9"                                                                                                                                     
[28845] "Retinoblastoma-Like-2_Protein"                                                                                                                                        
[28846] "RNA_Binding_Motif_Protein-5"                                                                                                                                          
[28847] "RNA_Binding_Motif_Protein-6"                                                                                                                                          
[28848] "RING_Box_Protein-1"                                                                                                                                                   
[28849] "Reticulocalbin-2"                                                                                                                                                     
[28850] "DNA_Topology_Regulation"                                                                                                                                              
[28851] "RET_Finger_Protein"                                                                                                                                                   
[28852] "RET_Finger_Protein-2"                                                                                                                                                 
[28853] "Naphthalene"                                                                                                                                                          
[28854] "Nicardipine"                                                                                                                                                          
[28855] "Nickel_Subsulfide"                                                                                                                                                    
[28856] "Nimesulide"                                                                                                                                                           
[28857] "Nitrogen_Dioxide"                                                                                                                                                     
[28858] "Week"                                                                                                                                                                 
[28859] "o-Aminoazotoluene"                                                                                                                                                    
[28860] "Month"                                                                                                                                                                
[28861] "Cresidine"                                                                                                                                                            
[28862] "Year"                                                                                                                                                                 
[28863] "Piperonyl_Butoxide"                                                                                                                                                   
[28864] "Pristane"                                                                                                                                                             
[28865] "Off_Study"                                                                                                                                                            
[28866] "Rebamipide"                                                                                                                                                           
[28867] "Silica"                                                                                                                                                               
[28868] "Sulindac_Sulfide"                                                                                                                                                     
[28869] "Theaflavins"                                                                                                                                                          
[28870] "Thiouracil"                                                                                                                                                           
[28871] "Translational_Regulation"                                                                                                                                             
[28872] "Triethylenemelamine"                                                                                                                                                  
[28873] "Translational_Activation"                                                                                                                                             
[28874] "Translational_Repression"                                                                                                                                             
[28875] "Tricaprylin"                                                                                                                                                          
[28876] "Process"                                                                                                                                                              
[28877] "Triphenylethylene"                                                                                                                                                    
[28878] "Vinyl_Carbamate"                                                                                                                                                      
[28879] "Zinc_Chloride"                                                                                                                                                        
[28880] "Pirinixic_Acid"                                                                                                                                                       
[28881] "Participant"                                                                                                                                                          
[28882] "Rhodopsin_Kinase"                                                                                                                                                     
[28883] "sn-1_2-Didecanoylglycerol"                                                                                                                                            
[28884] "LIM_Domain_Protein"                                                                                                                                                   
[28885] "Black_Tea"                                                                                                                                                            
[28886] "Receptor-Interacting_Serine-Threonine_Protein_Kinase-2"                                                                                                               
[28887] "Receptor-Interacting_Serine-Threonine_Protein_Kinase-3"                                                                                                               
[28888] "Ring_Finger_Protein-11"                                                                                                                                               
[28889] "Ribosomal_RNA-1"                                                                                                                                                      
[28890] "Ribonuclease-III"                                                                                                                                                     
[28891] "ROCK1_Protein"                                                                                                                                                        
[28892] "Family_Cancer_History"                                                                                                                                                
[28893] "Receptor_Tyrosine_Kinase-Like_Orphan_Receptor-1"                                                                                                                      
[28894] "Receptor_Tyrosine_Kinase-Like_Orphan_Receptor-2"                                                                                                                      
[28895] "RAR-Related_Orphan_Receptor-A"                                                                                                                                        
[28896] "Ribosomal_Protein-L10"                                                                                                                                                
[28897] "AS101"                                                                                                                                                                
[28898] "Vaccinia_Virus_Study"                                                                                                                                                 
[28899] "Cholesterol_Homeostasis"                                                                                                                                              
[28900] "Airborne_Particulate_Matter"                                                                                                                                          
[28901] "Californium-252_Fission_Neutron_Radiation"                                                                                                                            
[28902] "Mumps"                                                                                                                                                                
[28903] "Regressing_Friend_Leukemia_Virus"                                                                                                                                     
[28904] "Gastrectomy_with_Esophagojejunostomy"                                                                                                                                 
[28905] "Muscle_Relaxant_Preparation"                                                                                                                                          
[28906] "Unilateral_Oophorectomy"                                                                                                                                              
[28907] "Incomplete_Oophorectomy"                                                                                                                                              
[28908] "Thymectomy"                                                                                                                                                           
[28909] "Inhibition_of_Cancer_Cell_Growth"                                                                                                                                     
[28910] "Stimulation_of_Cancer_Cell_Growth"                                                                                                                                    
[28911] "Ovarian_Implantation"                                                                                                                                                 
[28912] "Pituitary_Isograft"                                                                                                                                                   
[28913] "Male_Gonadal_Ridge_Implantation"                                                                                                                                      
[28914] "Mechanical_Stimulation"                                                                                                                                               
[28915] "Moloney_Murine_Leukemia_Virus_TB"                                                                                                                                     
[28916] "Nodule-Inducing_Virus"                                                                                                                                                
[28917] "Ribosomal_Protein-L7A"                                                                                                                                                
[28918] "Ribosomal_Protein-S19"                                                                                                                                                
[28919] "Ribosomal_Protein-S27"                                                                                                                                                
[28920] "Ribosomal_Protein-S3"                                                                                                                                                 
[28921] "Murine_Retrovirus_Containing_Human_PDGFB_cDNA"                                                                                                                        
[28922] "RCAS-Akt"                                                                                                                                                             
[28923] "Ribosomal_Protein-S6_Kinase_Alpha-5"                                                                                                                                  
[28924] "RCAS-Ras"                                                                                                                                                             
[28925] "Ribosomal_Protein_S6_Kinase_Beta-2"                                                                                                                                   
[28926] "RAS-Related_Protein-RRAS2"                                                                                                                                            
[28927] "RAS-Like_Protein-RRP22"                                                                                                                                               
[28928] "R7_Virus"                                                                                                                                                             
[28929] "RAS_Suppressor_Protein-1"                                                                                                                                             
[28930] "Graffi_Murine_Leukemia_Virus"                                                                                                                                         
[28931] "Gross_Leukemia_Virus"                                                                                                                                                 
[28932] "Inactivated_Vaccinia_Virus"                                                                                                                                           
[28933] "LIM_Domains_Containing_1"                                                                                                                                             
[28934] "RYK_Receptor-Like_Tyrosine_Kinase"                                                                                                                                    
[28935] "Receptor_Serine-Threonine_Kinase"                                                                                                                                     
[28936] "LIM_Domain_Kinase-1"                                                                                                                                                  
[28937] "PINCH_Protein"                                                                                                                                                        
[28938] "S100_Calcium_Binding_Protein"                                                                                                                                         
[28939] "S100_Calcium_Binding_Protein-A11"                                                                                                                                     
[28940] "S100_Calcium_Binding_Protein-A12"                                                                                                                                     
[28941] "S100_Calcium_Binding_Protein-A8"                                                                                                                                      
[28942] "S100_Calcium_Binding_Protein-A9"                                                                                                                                      
[28943] "S100_Calcium_Binding_Protein-P"                                                                                                                                       
[28944] "SRC_Family_Associated_Phosphoprotein-2"                                                                                                                               
[28945] "Secretin_Receptor"                                                                                                                                                    
[28946] "Secreted_and_Transmembrane-1_Protein"                                                                                                                                 
[28947] "Ethnicity"                                                                                                                                                            
[28948] "Magnetic_Resonance_Spectroscopic_Imaging"                                                                                                                             
[28949] "Semaphorin-3E"                                                                                                                                                        
[28950] "Proteinase_Inhibitor_Gene"                                                                                                                                            
[28951] "Protease_Inhibitor-14"                                                                                                                                                
[28952] "Enzyme_Inhibitor_Gene"                                                                                                                                                
[28953] "Phosphatase-2A_Inhibitor-I2PP2A"                                                                                                                                      
[28954] "Histone-H3-K9_Methyltransferase-4"                                                                                                                                    
[28955] "Secreted_Frizzled-Related_Protein-4"                                                                                                                                  
[28956] "SH2-B_Homolog_Protein"                                                                                                                                                
[28957] "SH2_Domain_Containing_Protein-3A"                                                                                                                                     
[28958] "SH2_Domain_Containing_Protein-3C"                                                                                                                                     
[28959] "Recombinant_Vaccinia-Prostate_Specific_Antigen"                                                                                                                       
[28960] "SH2_Domain_Containing_Transforming_Protein-1"                                                                                                                         
[28961] "Recombinant_Vaccinia-Tyrosinase"                                                                                                                                      
[28962] "ACTG2_Gene"                                                                                                                                                           
[28963] "COL1A1_Gene"                                                                                                                                                          
[28964] "COL1A2_Gene"                                                                                                                                                          
[28965] "DHPS_Gene"                                                                                                                                                            
[28966] "EIF4EL3_Gene"                                                                                                                                                         
[28967] "HLA-DPB1_Gene"                                                                                                                                                        
[28968] "HNRPAB_Gene"                                                                                                                                                          
[28969] "LMNB1_Gene"                                                                                                                                                           
[28970] "MT3_Gene"                                                                                                                                                             
[28971] "MYH11_Gene"                                                                                                                                                           
[28972] "MYLK_Gene"                                                                                                                                                            
[28973] "NR4A1_Gene"                                                                                                                                                           
[28974] "SNRPF_Gene"                                                                                                                                                           
[28975] "Neuronal-SHC_Protein"                                                                                                                                                 
[28976] "Sonic_Hedgehog_Homolog_Protein"                                                                                                                                       
[28977] "_12q23_1"                                                                                                                                                             
[28978] "_17q21_3-q22_1"                                                                                                                                                       
[28979] "_19p13_2-p13_1"                                                                                                                                                       
[28980] "_5q35_3"                                                                                                                                                              
[28981] "_5q23_3-q31_1"                                                                                                                                                        
[28982] "_16p13_13-p13_12"                                                                                                                                                     
[28983] "Signal-Regulatory_Protein_Beta-1"                                                                                                                                     
[28984] "SKI-Like_Protein-SKIL"                                                                                                                                                
[28985] "Helicase-SKI2W"                                                                                                                                                       
[28986] "S-Phase_Kinase-Associated_Protein-2"                                                                                                                                  
[28987] "PUVA_Photochemotherapy"                                                                                                                                               
[28988] "Sodium_Chloride"                                                                                                                                                      
[28989] "Recombinant_Fowlpox-GM-CSF"                                                                                                                                           
[28990] "Recombinant_Vaccinia-GM-CSF"                                                                                                                                          
[28991] "Chloride_Anion_Exchanger"                                                                                                                                             
[28992] "Neuronal-SHC_Adaptor_Homolog_Protein"                                                                                                                                 
[28993] "Secretory_Leukocyte_Protease_Inhibitor"                                                                                                                               
[28994] "Smoothened_Homolog_Protein"                                                                                                                                           
[28995] "Ibritumomab_Tiuxetan"                                                                                                                                                 
[28996] "ALVAC-CEA_6D_B7_1_Vaccine"                                                                                                                                            
[28997] "Anti-MUC-1_Monoclonal_Antibody"                                                                                                                                       
[28998] "Fluorouracil_Interferon-alpha_Interleukin-2_Leucovorin-Calcium"                                                                                                       
[28999] "Interleukin-1-beta_New_Formulation"                                                                                                                                   
[29000] "Interleukin-2_Jurkat_Derived"                                                                                                                                         
[29001] "Lidocaine_Oral_Solution"                                                                                                                                              
[29002] "Lidocaine_Patch"                                                                                                                                                      
[29003] "Lidocaine_Topical"                                                                                                                                                    
[29004] "Monoclonal_Antibody_CC-46"                                                                                                                                            
[29005] "Serum-Inducible_Kinase"                                                                                                                                               
[29006] "Cyclin-E_Binding_Protein-1"                                                                                                                                           
[29007] "SKI-Interacting_Protein"                                                                                                                                              
[29008] "Signal_Recognition_Particle-19kDa"                                                                                                                                    
[29009] "Sushi-Repeat_Protein"                                                                                                                                                 
[29010] "Spectrin_SH3-Domain_Binding_Protein-1"                                                                                                                                
[29011] "Sarcospan"                                                                                                                                                            
[29012] "Heat_Shock_70kD_Protein_Binding_Protein"                                                                                                                              
[29013] "CTP-37-DT_Vaccine"                                                                                                                                                    
[29014] "Link_Guanine_Nucleotide_Exchange_Factor-II"                                                                                                                           
[29015] "BCSC-1"                                                                                                                                                               
[29016] "Suppression_of_Tumorigenicity-7_Protein"                                                                                                                              
[29017] "Stanniocalcin-1"                                                                                                                                                      
[29018] "Stanniocalcin-2"                                                                                                                                                      
[29019] "Serine-Threonine_Kinase-6"                                                                                                                                            
[29020] "Protein_Translation_Factor-SUI1_Homolog_Protein"                                                                                                                      
[29021] "US_State"                                                                                                                                                             
[29022] "Actin_Gamma-2"                                                                                                                                                        
[29023] "Cell_Mobility"                                                                                                                                                        
[29024] "Collagen_I_Alpha-1"                                                                                                                                                   
[29025] "Gas_Chromatography"                                                                                                                                                   
[29026] "Collagen_I_Alpha-2"                                                                                                                                                   
[29027] "Deoxyhypusine_Synthase"                                                                                                                                               
[29028] "Amino_Acid_Biosynthesis"                                                                                                                                              
[29029] "Eukaryotic_Translation_Initiation_Factor-4E-Like-3_Protein"                                                                                                           
[29030] "Translation_Process"                                                                                                                                                  
[29031] "Translation_Initiation"                                                                                                                                               
[29032] "HLA-DP_Histocompatibility_Type_Beta-1_Subunit"                                                                                                                        
[29033] "Heterogeneous_Nuclear_Ribonucleoprotein-AB"                                                                                                                           
[29034] "Transcriptional_Co-Activator-CRSP100"                                                                                                                                 
[29035] "Transforming_Acidic_Coiled-Coil_Containing_Protein-3"                                                                                                                 
[29036] "Mouse_Ovarian_Disorder"                                                                                                                                               
[29037] "Mouse_Non-Neoplastic_Ovarian_Proliferative_Disorder"                                                                                                                  
[29038] "Mouse_Ovarian_Neoplasm"                                                                                                                                               
[29039] "Mouse_Cystic_or_Papillary_Hyperplasia"                                                                                                                                
[29040] "Mouse_Sex_Cord_Stromal_Hyperplasia"                                                                                                                                   
[29041] "Mouse_Tubulostromal_Hyperplasia"                                                                                                                                      
[29042] "Mouse_Ovarian_Cysts"                                                                                                                                                  
[29043] "Mouse_Ovarian_Angiectasis"                                                                                                                                            
[29044] "Mouse_Benign_Ovarian_Neoplasm"                                                                                                                                        
[29045] "Mouse_Malignant_Ovarian_Neoplasm"                                                                                                                                     
[29046] "Mouse_Ovarian_Tubulostromal_Adenoma"                                                                                                                                  
[29047] "Mouse_Ovarian_Cystadenoma"                                                                                                                                            
[29048] "Mouse_Benign_Luteoma"                                                                                                                                                 
[29049] "Mouse_Benign_Ovarian_Teratoma"                                                                                                                                        
[29050] "Mouse_Benign_Thecoma"                                                                                                                                                 
[29051] "Mouse_Benign_Granulosa_Cell_Tumor"                                                                                                                                    
[29052] "Mouse_Benign_Sertoli_Cell_Tumor"                                                                                                                                      
[29053] "Mouse_Benign_Sex_Cord_Stromal_Mixed_Tumor"                                                                                                                            
[29054] "Mouse_Ovarian_Hemangioma"                                                                                                                                             
[29055] "Mouse_Ovarian_Tubulostromal_Adenocarcinoma"                                                                                                                           
[29056] "Mouse_Ovarian_Cystadenocarcinoma"                                                                                                                                     
[29057] "Mouse_Ovarian_Embryonal_Carcinoma"                                                                                                                                    
[29058] "Mouse_Yolk_Sac_Carcinoma"                                                                                                                                             
[29059] "Mouse_Choriocarcinoma"                                                                                                                                                
[29060] "Mouse_Malignant_Ovarian_Thecoma"                                                                                                                                      
[29061] "Mouse_Malignant_Ovarian_Granulosa_Cell_Tumor"                                                                                                                         
[29062] "Mouse_Malignant_Ovarian_Sertoli_Cell_Tumor"                                                                                                                           
[29063] "Mouse_Ovarian_Hemangiosarcoma"                                                                                                                                        
[29064] "Mouse_Ovarian_Histiocytic_Sarcoma"                                                                                                                                    
[29065] "Tachykinin_Receptor-3"                                                                                                                                                
[29066] "TBP-Related_Factor-10"                                                                                                                                                
[29067] "TBP-Associated_Factor-11"                                                                                                                                             
[29068] "TBP-Associated_Factor-20kDa"                                                                                                                                          
[29069] "TBP-Associated_Factor-15kDa"                                                                                                                                          
[29070] "TBP-Associated_Factor-13"                                                                                                                                             
[29071] "TBP-Associated_Factor-2"                                                                                                                                              
[29072] "TBP-Associated_Factor-140kDa"                                                                                                                                         
[29073] "TBP-Associated_Factor-4"                                                                                                                                              
[29074] "TBP-Associated_Factor-5"                                                                                                                                              
[29075] "TBP-Associated_Factor-6"                                                                                                                                              
[29076] "TBP-Associated_Factor-F"                                                                                                                                              
[29077] "TBP-Associated_Factor-50kDa"                                                                                                                                          
[29078] "Taube_Nuss_Homologue_Protein"                                                                                                                                         
[29079] "TBP-Associated_Factor-9"                                                                                                                                              
[29080] "T-Cell_Acute_Lymphocytic_Leukemia-2_Protein"                                                                                                                          
[29081] "Intermediate_Filament_Gene"                                                                                                                                           
[29082] "Lamin-B1"                                                                                                                                                             
[29083] "Metallothionein-3"                                                                                                                                                    
[29084] "Transcriptional_Coactivator_with_PDZ-Binding_Motif"                                                                                                                   
[29085] "TANK-Binding_Kinase-1"                                                                                                                                                
[29086] "TBP-Like_Protein-1"                                                                                                                                                   
[29087] "Transcription_Factor-3"                                                                                                                                               
[29088] "Transcription_Factor-7-Like-2_Protein"                                                                                                                                
[29089] "T-Cell_Leukemia_Lymphoma_1B_Protein"                                                                                                                                  
[29090] "TCTA_Protein"                                                                                                                                                         
[29091] "TEC_Protein_Tyrosine_Kinase"                                                                                                                                          
[29092] "Smooth_Muscle_Myosin_Heavy_Chain-11"                                                                                                                                  
[29093] "Muscle_Contraction"                                                                                                                                                   
[29094] "Myosin_Light_Polypeptide_Kinase"                                                                                                                                      
[29095] "Early_Response_Protein-NAK1"                                                                                                                                          
[29096] "snRNP_Structural_Core_Protein"                                                                                                                                        
[29097] "Small_Nuclear_Ribonucleoprotein_Polypeptide-F"                                                                                                                        
[29098] "snRNP_Biogenesis"                                                                                                                                                     
[29099] "Transcription_Factor-DP2"                                                                                                                                             
[29100] "Transcription_Factor-E3"                                                                                                                                              
[29101] "Cardiac_Muscle_Contraction"                                                                                                                                           
[29102] "Basal_Transcription_Factor_Gene"                                                                                                                                      
[29103] "LYL1_Protein"                                                                                                                                                         
[29104] "Transforming_Growth_Factor_Beta_Receptor-I"                                                                                                                           
[29105] "Transforming_Growth_Factor_Beta_Receptor-III"                                                                                                                         
[29106] "Protein_Receptor_Tyrosine_Kinase-TIE1"                                                                                                                                
[29107] "Toll-Like_Receptor-1"                                                                                                                                                 
[29108] "Toll-Like_Receptor-2"                                                                                                                                                 
[29109] "Stable"                                                                                                                                                               
[29110] "Toll-Like_Receptor-3"                                                                                                                                                 
[29111] "Toll-Like_Receptor-4"                                                                                                                                                 
[29112] "Toll-Like_Receptor-5"                                                                                                                                                 
[29113] "Toll-Like_Receptor-6"                                                                                                                                                 
[29114] "Toll-Like_Receptor-7"                                                                                                                                                 
[29115] "Toll-Like_Receptor-8"                                                                                                                                                 
[29116] "Transmembrane_Protease_Serine-2"                                                                                                                                      
[29117] "Osteoprotegerin"                                                                                                                                                      
[29118] "FAS_Ligand_Decoy_Receptor"                                                                                                                                            
[29119] "Osteoprotegerin_Ligand"                                                                                                                                               
[29120] "Non-Receptor_Tyrosine_Kinase-1"                                                                                                                                       
[29121] "Toll-Interacting_Protein"                                                                                                                                             
[29122] "Tumor_Protein-D52"                                                                                                                                                    
[29123] "Tumor_Protein-D52-Like-1_Protein"                                                                                                                                     
[29124] "Phosphoprotein_Associated_with_GEMs"                                                                                                                                  
[29125] "p21-Activated_Kinase-6"                                                                                                                                               
[29126] "Apoptosis_Response_Protein"                                                                                                                                           
[29127] "Smooth_Endoplasmic_Reticulum"                                                                                                                                         
[29128] "Tax_Interaction_Protein-40"                                                                                                                                           
[29129] "Paired_Box_Protein_Pax-3"                                                                                                                                             
[29130] "Paired_Box-5_Protein"                                                                                                                                                 
[29131] "TNF_Receptor-Associated_Factor-6"                                                                                                                                     
[29132] "Taxol_Resistance_Associated_Protein-3"                                                                                                                                
[29133] "Multiple_Membrane_Spanning_Receptor-TRC8"                                                                                                                             
[29134] "T-Cell_Receptor_Interacting_Molecule"                                                                                                                                 
[29135] "Triple_Functional_Domain_Protein"                                                                                                                                     
[29136] "Thyroid_Hormone_Receptor_Interactor-10"                                                                                                                               
[29137] "MLSN1_and_TRP-Related_Protein"                                                                                                                                        
[29138] "Transformation-Transcription_Domain-Associated_Protein"                                                                                                               
[29139] "Thyroid_Stimulating_Hormone_Receptor"                                                                                                                                 
[29140] "Testis-Specific_Kinase_Substrate"                                                                                                                                     
[29141] "Thymic_Stromal_Lymphopoietin"                                                                                                                                         
[29142] "Interferon_Alfa-N3"                                                                                                                                                   
[29143] "Paired_Box_Protein_Pax-7"                                                                                                                                             
[29144] "Pre-B-Cell_Colony-Enhancing_Factor"                                                                                                                                   
[29145] "Pre-B-Cell_Leukemia_Transcription_Factor-3"                                                                                                                           
[29146] "Extremities"                                                                                                                                                          
[29147] "Constitutional_Finding"                                                                                                                                               
[29148] "Transfusion_History"                                                                                                                                                  
[29149] "Lerisetron"                                                                                                                                                           
[29150] "Human_Achaete-Scute_Homolog-1_Protein"                                                                                                                                
[29151] "Testis-Specific_Y-Encoded_Protein"                                                                                                                                    
[29152] "Tetratricopeptide_Repeat_Protein-4"                                                                                                                                   
[29153] "TTK_Protein_Kinase"                                                                                                                                                   
[29154] "TYRO3_Protein_Tyrosine_Kinase"                                                                                                                                        
[29155] "TYRO_Protein_Tyrosine_Kinase_Binding_Protein"                                                                                                                         
[29156] "Ubiquitin-Conjugating_Enzyme-E2D2"                                                                                                                                    
[29157] "UNC-13_Homolog-B_Protein"                                                                                                                                             
[29158] "WD_Repeat_Domain_Protein-22"                                                                                                                                          
[29159] "C_Motif_Chemokine_Ligand-2"                                                                                                                                           
[29160] "GH1_Gene"                                                                                                                                                             
[29161] "_17q24_2"                                                                                                                                                             
[29162] "ADA_Gene"                                                                                                                                                             
[29163] "_1p36_23-p35_1"                                                                                                                                                       
[29164] "_20q12-q13_11"                                                                                                                                                        
[29165] "Activated_RNA_Polymerase_II_Transcription_Cofactor-4"                                                                                                                 
[29166] "PCTAIRE_Protein_Kinase-1"                                                                                                                                             
[29167] "Phosducin"                                                                                                                                                            
[29168] "Platelet-Derived_Growth_Factor_Alpha"                                                                                                                                 
[29169] "Platelet-Derived_Growth_Factor_Receptor_Alpha_Polypeptide"                                                                                                            
[29170] "Platelet-Derived_Growth_Factor_Receptor_Beta_Polypeptide"                                                                                                             
[29171] "Platelet-Derived_Growth_Factor_Receptor-Like_Protein"                                                                                                                 
[29172] "PKB_Kinase"                                                                                                                                                           
[29173] "Protein_Inhibitor_of_Activated_STAT3_Protein"                                                                                                                         
[29174] "Phosphoinositide-3-Kinase_Catalytic_Alpha_Polypeptide"                                                                                                                
[29175] "Phosphoinositide-3-Kinase_Catalytic_Beta_Polypeptide"                                                                                                                 
[29176] "Phosphoinositide-3-Kinase_Catalytic_Gamma_Polypeptide"                                                                                                                
[29177] "Phosphoinositide-3-Kinase_Regulatory_Subunit_Polypeptide-3"                                                                                                           
[29178] "Phosphoinositide-4-Kinase_Catalytic_Beta_Polypeptide"                                                                                                                 
[29179] "EVI2B_Protein"                                                                                                                                                        
[29180] "Enhancer_of_Zeste_Homolog_2_Protein"                                                                                                                                  
[29181] "Fatty_Acid_Binding_Protein-5"                                                                                                                                         
[29182] "Abdominal_Aorta"                                                                                                                                                      
[29183] "Abdominal_Aorta_Branch"                                                                                                                                               
[29184] "Abdominal_Muscle"                                                                                                                                                     
[29185] "Accessory_Nerve"                                                                                                                                                      
[29186] "Acetabulum"                                                                                                                                                           
[29187] "Achilles_Tendon"                                                                                                                                                      
[29188] "Acidophilic_Cell"                                                                                                                                                     
[29189] "Acinar_Salivary_Gland_System"                                                                                                                                         
[29190] "Acromial_Thoracic_Artery"                                                                                                                                             
[29191] "Acromioclavicular_Joint"                                                                                                                                              
[29192] "Acromion"                                                                                                                                                             
[29193] "Activated_Lymphocyte"                                                                                                                                                 
[29194] "Adrenal_Gland_Capsule"                                                                                                                                                
[29195] "Adrenal_Gland_Tissue"                                                                                                                                                 
[29196] "Alpha_Cell"                                                                                                                                                           
[29197] "Alveolar_Cell"                                                                                                                                                        
[29198] "Alveolar_Cell_Type_I"                                                                                                                                                 
[29199] "Alveolar_Cell_Type_II"                                                                                                                                                
[29200] "Alveolar_Duct"                                                                                                                                                        
[29201] "Alveolar_Sac"                                                                                                                                                         
[29202] "Alveus"                                                                                                                                                               
[29203] "Ambient_Cistern"                                                                                                                                                      
[29204] "A-Microtubule"                                                                                                                                                        
[29205] "Amphiarthrosis"                                                                                                                                                       
[29206] "Ampullary_Crest"                                                                                                                                                      
[29207] "Ampullary_Segment_of_the_Fallopian_Tube"                                                                                                                              
[29208] "Amygdaloid_Body"                                                                                                                                                      
[29209] "Anal_Column"                                                                                                                                                          
[29210] "Anal_Gland"                                                                                                                                                           
[29211] "Anal_Region"                                                                                                                                                          
[29212] "Anal_Sinus"                                                                                                                                                           
[29213] "Anal_Squamous_Zone"                                                                                                                                                   
[29214] "Anal_Transitional_Zone"                                                                                                                                               
[29215] "Anastomosing_Tubule_of_the_Smooth_Endoplasmic_Reticulum"                                                                                                              
[29216] "Anastomotica_Magna_Artery"                                                                                                                                            
[29217] "Angular_Artery"                                                                                                                                                       
[29218] "Angular_Gyrus"                                                                                                                                                        
[29219] "Ankle_Joint"                                                                                                                                                          
[29220] "Anterior_Annular_Ligament"                                                                                                                                            
[29221] "Anterior_Carpal_Artery"                                                                                                                                               
[29222] "Anterior_Caudate_Vein"                                                                                                                                                
[29223] "Anterior_Cerebral_Artery_Branch"                                                                                                                                      
[29224] "Anterior_Choroidal_Artery"                                                                                                                                            
[29225] "Anterior_Circulation_Intracranial_Artery"                                                                                                                             
[29226] "Anterior_Circumflex_Artery"                                                                                                                                           
[29227] "Anterior_Commissure"                                                                                                                                                  
[29228] "Anterior_Communicating_Artery"                                                                                                                                        
[29229] "Anterior_Cruciate_Ligament"                                                                                                                                           
[29230] "Anterior_Descending_Coronary_Artery"                                                                                                                                  
[29231] "Anterior_Fossa"                                                                                                                                                       
[29232] "Anterior_Inferior_Cerebellar_Artery"                                                                                                                                  
[29233] "Anterior_Inferior_Frontal_Convolution"                                                                                                                                
[29234] "Anterior_Infratentorial_Cistern"                                                                                                                                      
[29235] "Anterior_Jugular_Vein"                                                                                                                                                
[29236] "Anterior_Longitudinal_Ligament"                                                                                                                                       
[29237] "Anterior_Median_Fissure_of_Spinal_Cord"                                                                                                                               
[29238] "Anterior_Mediastinal_Lymph_Node"                                                                                                                                      
[29239] "Anterior_Mediastinum"                                                                                                                                                 
[29240] "Anterior_Meningeal_Artery"                                                                                                                                            
[29241] "Anterior_Olfactory_Lobule"                                                                                                                                            
[29242] "Anterior_Parietal_Artery"                                                                                                                                             
[29243] "Anterior_Part_of_the_Calcarine_Fissure"                                                                                                                               
[29244] "Anterior_Pole_of_the_Lens"                                                                                                                                            
[29245] "Anterior_Portion_of_the_Corpus_Callosum_Cistern"                                                                                                                      
[29246] "Anterior_Quadrigeminal_Body"                                                                                                                                          
[29247] "Anterior_Supratentorial_Cistern"                                                                                                                                      
[29248] "Anterior_Surface_of_the_Kidney"                                                                                                                                       
[29249] "Anterior_Surface_of_the_Lens"                                                                                                                                         
[29250] "Anterior_Surface_of_the_Liver"                                                                                                                                        
[29251] "Anterior_Surface_of_the_Stomach"                                                                                                                                      
[29252] "Anterior_Surface_of_the_Vagina"                                                                                                                                       
[29253] "Anterior_Temporal_Artery"                                                                                                                                             
[29254] "Anterior_Tibial_Artery_Branch"                                                                                                                                        
[29255] "Anterior_Tibial_Vein"                                                                                                                                                 
[29256] "Anterior_Ulnar_Vein"                                                                                                                                                  
[29257] "Anterior_Wall_of_the_Tympanum"                                                                                                                                        
[29258] "Antero-lateral_Ascending_Tract"                                                                                                                                       
[29259] "Antero-lateral_Column"                                                                                                                                                
[29260] "Antihelix"                                                                                                                                                            
[29261] "Antitragus"                                                                                                                                                           
[29262] "Aortic_Arch"                                                                                                                                                          
[29263] "Aortic_Arch_Branch"                                                                                                                                                   
[29264] "Aortic_Opening"                                                                                                                                                       
[29265] "Apex_of_the_Heart"                                                                                                                                                    
[29266] "Apex_of_the_Lung"                                                                                                                                                     
[29267] "Apex_of_the_Pericardium"                                                                                                                                              
[29268] "Apex_of_the_Tongue"                                                                                                                                                   
[29269] "Apical_Domain_of_the_Epithelium"                                                                                                                                      
[29270] "Apocrine_Sweat_Gland"                                                                                                                                                 
[29271] "Aponeurosis"                                                                                                                                                          
[29272] "Aqueduct_of_Sylvius"                                                                                                                                                  
[29273] "Arachnoid_Membrane"                                                                                                                                                   
[29274] "Arachnoid_Villus"                                                                                                                                                     
[29275] "Arch_of_the_Vertebra"                                                                                                                                                 
[29276] "Area_of_Broca"                                                                                                                                                        
[29277] "Argentaffin_Cell"                                                                                                                                                     
[29278] "Arm"                                                                                                                                                                  
[29279] "Arteriovenous_Shunt"                                                                                                                                                  
[29280] "Articular_Bone_Surface"                                                                                                                                               
[29281] "Articular_Cartilage"                                                                                                                                                  
[29282] "Articular_Muscle"                                                                                                                                                     
[29283] "Aryepiglottic_Muscle"                                                                                                                                                 
[29284] "Aryteno-epiglottic_Fold"                                                                                                                                              
[29285] "Arytenoid_Cartilage"                                                                                                                                                  
[29286] "Arytenoid_Muscle"                                                                                                                                                     
[29287] "Ascending_Aorta"                                                                                                                                                      
[29288] "Ascending_Aorta_Branch"                                                                                                                                               
[29289] "Ascending_Frontal_Artery"                                                                                                                                             
[29290] "Ascending_Frontal_Convolution"                                                                                                                                        
[29291] "Ascending_Limb_of_the_Henle_s_Loop"                                                                                                                                   
[29292] "Ascending_Parietal_Convolution"                                                                                                                                       
[29293] "Astragalus"                                                                                                                                                           
[29294] "Atlanto-axial_Joint"                                                                                                                                                  
[29295] "Atlanto-occipital_Joint"                                                                                                                                              
[29296] "Atlas_of_the_Vertebra"                                                                                                                                                
[29297] "Atrioventricular_Bundle"                                                                                                                                              
[29298] "Atrioventricular_Node"                                                                                                                                                
[29299] "Atrium_of_the_Middle_Ear"                                                                                                                                             
[29300] "Attachment_Plaque"                                                                                                                                                    
[29301] "Auditory_Ossicle"                                                                                                                                                     
[29302] "Auricle"                                                                                                                                                              
[29303] "Autophagolysosome"                                                                                                                                                    
[29304] "Autophagosome"                                                                                                                                                        
[29305] "Autosome"                                                                                                                                                             
[29306] "Axillary_Artery"                                                                                                                                                      
[29307] "Axillary_Artery_Branch"                                                                                                                                               
[29308] "Axillary_Vein"                                                                                                                                                        
[29309] "Axial_Skeleton"                                                                                                                                                       
[29310] "Axis_of_the_Centriole"                                                                                                                                                
[29311] "Axis_of_the_Vertebra"                                                                                                                                                 
[29312] "Axoaxonic_Synapse"                                                                                                                                                    
[29313] "Axodendritic_Synapse"                                                                                                                                                 
[29314] "Axon"                                                                                                                                                                 
[29315] "Axosomatic_Synapse"                                                                                                                                                   
[29316] "Azurophilic_Granule"                                                                                                                                                  
[29317] "Azygos_Articular_Artery"                                                                                                                                              
[29318] "Balbiani_Body"                                                                                                                                                        
[29319] "Barr_Body"                                                                                                                                                            
[29320] "Basal_Body"                                                                                                                                                           
[29321] "Basal_Cerebral_Vein_of_the_Rosenthal"                                                                                                                                 
[29322] "Basal_Domain_of_the_Epithelium"                                                                                                                                       
[29323] "Basal_Lamina"                                                                                                                                                         
[29324] "Basal_Lamina_Collagen"                                                                                                                                                
[29325] "Basal_Lamina_of_the_Vascular_Endothelium"                                                                                                                             
[29326] "Basal_Layer_of_the_Endometrium"                                                                                                                                       
[29327] "Basaloid_Cell"                                                                                                                                                        
[29328] "Base_of_the_Brain"                                                                                                                                                    
[29329] "Base_of_the_Lung"                                                                                                                                                     
[29330] "Base_of_the_Pericardium"                                                                                                                                              
[29331] "Basilar_Artery_Branch"                                                                                                                                                
[29332] "Basilar_Membrane_of_the_Membranous_Canal_of_the_Cochlea"                                                                                                              
[29333] "Basilic_Vein"                                                                                                                                                         
[29334] "Basophilic_Cell"                                                                                                                                                      
[29335] "Beta_Cell"                                                                                                                                                            
[29336] "Biceps"                                                                                                                                                               
[29337] "Bicuspid_Tooth"                                                                                                                                                       
[29338] "Bile_Canaliculus"                                                                                                                                                     
[29339] "Bile_Salt"                                                                                                                                                            
[29340] "Birbeck_Granule"                                                                                                                                                      
[29341] "Bladder_Mucosa"                                                                                                                                                       
[29342] "Bladder_Muscular_Coat"                                                                                                                                                
[29343] "Bladder_Muscularis_Mucosa"                                                                                                                                            
[29344] "Bladder_Serosal_Surface"                                                                                                                                              
[29345] "Bladder_Tissue"                                                                                                                                                       
[29346] "Bladder_Transitional_Cell"                                                                                                                                            
[29347] "Bladder_Transitional_Cell_Epithelium"                                                                                                                                 
[29348] "Blood_Capillary"                                                                                                                                                      
[29349] "Blood_Vessel_Tissue"                                                                                                                                                  
[29350] "B-Microtubule"                                                                                                                                                        
[29351] "Body_Cavity"                                                                                                                                                          
[29352] "Body_of_the_Corpus_Callosum"                                                                                                                                          
[29353] "Body_of_the_Epididymis"                                                                                                                                               
[29354] "Body_of_the_Lateral_Ventricle"                                                                                                                                        
[29355] "Body_of_the_Nail"                                                                                                                                                     
[29356] "Body_of_the_Spermatozoon"                                                                                                                                             
[29357] "Body_Part"                                                                                                                                                            
[29358] "Bone_Matrix"                                                                                                                                                          
[29359] "Bone_of_the_Extremity"                                                                                                                                                
[29360] "Bone_Surface"                                                                                                                                                         
[29361] "Bowman_s_Capsule"                                                                                                                                                     
[29362] "Bowman_s_Membrane"                                                                                                                                                    
[29363] "Brachial_Artery_Branch"                                                                                                                                               
[29364] "Brain_Infundibulum"                                                                                                                                                   
[29365] "Bronchial_Artery"                                                                                                                                                     
[29366] "Bronchial_Epithelium"                                                                                                                                                 
[29367] "Bronchial_Lymph_Node"                                                                                                                                                 
[29368] "Bronchial_Tree"                                                                                                                                                       
[29369] "Bronchus-Associated_Lymphoid_Tissue"                                                                                                                                  
[29370] "Brown_Adipose_Tissue"                                                                                                                                                 
[29371] "Brush_Cell"                                                                                                                                                           
[29372] "Buccal_Salivary_Gland"                                                                                                                                                
[29373] "C1_Vertebra"                                                                                                                                                          
[29374] "C2_Vertebra"                                                                                                                                                          
[29375] "C3_Vertebra"                                                                                                                                                          
[29376] "C4_Vertebra"                                                                                                                                                          
[29377] "C5_Vertebra"                                                                                                                                                          
[29378] "C6_Vertebra"                                                                                                                                                          
[29379] "C7_Vertebra"                                                                                                                                                          
[29380] "CA1_Field_of_the_Cornu_Ammonis"                                                                                                                                       
[29381] "CA2_Field_of_the_Cornu_Ammonis"                                                                                                                                       
[29382] "CA3_Field_of_the_Cornu_Ammonis"                                                                                                                                       
[29383] "CA4_Field_of_the_Cornu_Ammonis"                                                                                                                                       
[29384] "Calcaneum"                                                                                                                                                            
[29385] "Calcarine_Artery"                                                                                                                                                     
[29386] "Calcarine_Sulcus"                                                                                                                                                     
[29387] "Callosomarginal_Artery"                                                                                                                                               
[29388] "Canal_for_Tensor_Tympani"                                                                                                                                             
[29389] "Canal_of_Hering"                                                                                                                                                      
[29390] "Canal_of_Schlemm"                                                                                                                                                     
[29391] "Canalis_Radicis_Dentis"                                                                                                                                               
[29392] "Canine_Tooth"                                                                                                                                                         
[29393] "Capsular_Ligament"                                                                                                                                                    
[29394] "Cardia_Gland"                                                                                                                                                         
[29395] "Cardia_Orifice"                                                                                                                                                       
[29396] "Carotid_Cistern"                                                                                                                                                      
[29397] "Carpal_Joint"                                                                                                                                                         
[29398] "Carpometacarpal_Joint"                                                                                                                                                
[29399] "Carpus_Bone"                                                                                                                                                          
[29400] "Cartilage_Matrix"                                                                                                                                                     
[29401] "Cartilagenous_Tissue"                                                                                                                                                 
[29402] "Cavum_Conchae"                                                                                                                                                        
[29403] "Perikaryon"                                                                                                                                                           
[29404] "Cell_of_the_Epidermis"                                                                                                                                                
[29405] "Cell-to-extracellular_Matrix_Junction"                                                                                                                                
[29406] "Cellular_Pump"                                                                                                                                                        
[29407] "Cementoblast"                                                                                                                                                         
[29408] "Cementocyte"                                                                                                                                                          
[29409] "Cementum"                                                                                                                                                             
[29410] "Central_Artery"                                                                                                                                                       
[29411] "Central_Lobe"                                                                                                                                                         
[29412] "Central_Pore_of_the_Nuclear_Pore_Complex"                                                                                                                             
[29413] "Central_Sulcus_of_Rolando"                                                                                                                                            
[29414] "Central_Vein"                                                                                                                                                         
[29415] "Central_Zone_of_the_Prostatic_Parenchyma"                                                                                                                             
[29416] "Centriole"                                                                                                                                                            
[29417] "Centromedian_Nucleus_of_the_Thalamus"                                                                                                                                 
[29418] "Centrosome"                                                                                                                                                           
[29419] "Cephalic_Vein"                                                                                                                                                        
[29420] "Cerebral_Aqueduct"                                                                                                                                                    
[29421] "Cerebral_Fissure"                                                                                                                                                     
[29422] "Cerebral_Fornix"                                                                                                                                                      
[29423] "Cerebral_Gyrus"                                                                                                                                                       
[29424] "Cerebral_Peduncle"                                                                                                                                                    
[29425] "Cerebral_Sulcus"                                                                                                                                                      
[29426] "Cerumen"                                                                                                                                                              
[29427] "Ceruminous_Gland"                                                                                                                                                     
[29428] "Cervical_Curve"                                                                                                                                                       
[29429] "Cervical_Gland"                                                                                                                                                       
[29430] "Cervical_Gland_Secretion"                                                                                                                                             
[29431] "Cervical_Lymph_Node"                                                                                                                                                  
[29432] "Cervical_Nerve"                                                                                                                                                       
[29433] "Chamber_of_the_Eye"                                                                                                                                                   
[29434] "Chemical_Synapse"                                                                                                                                                     
[29435] "Chemical_Synapse_Component"                                                                                                                                           
[29436] "Chiasmatic_Cistern"                                                                                                                                                   
[29437] "Chief_Cell_of_the_Stomach"                                                                                                                                            
[29438] "Chondroblast"                                                                                                                                                         
[29439] "Chordae_Tendineae"                                                                                                                                                    
[29440] "Choroid_Plexus_of_the_Fourth_Ventricle"                                                                                                                               
[29441] "Choroid_Plexus_of_the_Lateral_Ventricle"                                                                                                                              
[29442] "Choroidal_Artery"                                                                                                                                                     
[29443] "Choroidal_Fissure"                                                                                                                                                    
[29444] "Chromatin_Fibril"                                                                                                                                                     
[29445] "Chromophobe_Cell"                                                                                                                                                     
[29446] "Ciliary_Epithelium"                                                                                                                                                   
[29447] "Ciliary_Muscle"                                                                                                                                                       
[29448] "Ciliary_Process"                                                                                                                                                      
[29449] "Ciliated_Bronchial_Epithelial_Cell"                                                                                                                                   
[29450] "Cilium"                                                                                                                                                               
[29451] "Cilium_Microtubule"                                                                                                                                                   
[29452] "Circular_Ligament_of_the_Tooth"                                                                                                                                       
[29453] "Circular_Sulcus"                                                                                                                                                      
[29454] "Circumvallate_Papilla"                                                                                                                                                
[29455] "Cis-Golgi_Network"                                                                                                                                                    
[29456] "Cisterna_Magna"                                                                                                                                                       
[29457] "Cisterna_of_the_Endosome"                                                                                                                                             
[29458] "Cisterna_of_the_Golgi_Apparatus"                                                                                                                                      
[29459] "Cisterna_of_the_Rough_Endoplasmic_Reticulum"                                                                                                                          
[29460] "Classic_Lobule"                                                                                                                                                       
[29461] "Claustrum"                                                                                                                                                            
[29462] "C-Microtubule"                                                                                                                                                        
[29463] "Coated_Vesicle"                                                                                                                                                       
[29464] "Coccygeal_Muscle"                                                                                                                                                     
[29465] "Coccygeal_Nerve"                                                                                                                                                      
[29466] "Coccygeal_Vertebra"                                                                                                                                                   
[29467] "Cochlear_Duct"                                                                                                                                                        
[29468] "Cochlear_Labyrinth"                                                                                                                                                   
[29469] "Cochlear_Nucleus"                                                                                                                                                     
[29470] "Collagen_Fiber"                                                                                                                                                       
[29471] "Collagen_Fibril"                                                                                                                                                      
[29472] "Collateral_Fissure"                                                                                                                                                   
[29473] "Collateral_Gyrus"                                                                                                                                                     
[29474] "Collateral_Sulcus"                                                                                                                                                    
[29475] "Collecting_Cell"                                                                                                                                                      
[29476] "Collecting_Tube"                                                                                                                                                      
[29477] "Colloid"                                                                                                                                                              
[29478] "Collum_Dentis"                                                                                                                                                        
[29479] "Colorectal_Zone_of_the_Anal_Canal"                                                                                                                                    
[29480] "Colostrum"                                                                                                                                                            
[29481] "Commissure"                                                                                                                                                           
[29482] "Common_Bony_Limb"                                                                                                                                                     
[29483] "Common_Canaliculus"                                                                                                                                                   
[29484] "Common_Carotid_Artery"                                                                                                                                                
[29485] "Common_Carotid_Artery_Branch"                                                                                                                                         
[29486] "Common_Femoral_Artery"                                                                                                                                                
[29487] "Common_Femoral_Artery_Branch"                                                                                                                                         
[29488] "Common_Hepatic_Duct"                                                                                                                                                  
[29489] "Common_Iliac_Artery"                                                                                                                                                  
[29490] "Common_Iliac_Artery_Branch"                                                                                                                                           
[29491] "Common_Iliac_Vein"                                                                                                                                                    
[29492] "Common_Thymocyte"                                                                                                                                                     
[29493] "Common_Ulnar_Vein"                                                                                                                                                    
[29494] "Concha"                                                                                                                                                               
[29495] "Condensed_Configuration_of_the_Mitochondrion"                                                                                                                         
[29496] "Conjunctival_Epithelium"                                                                                                                                              
[29497] "Connecting_Segment_of_the_Photoreceptor_Cell"                                                                                                                         
[29498] "Connective_Tissue_Component_of_the_Peripheral_Nerve"                                                                                                                  
[29499] "Connective_Tissue_Fiber"                                                                                                                                              
[29500] "Connective_Tissue_Proper"                                                                                                                                             
[29501] "Continuous_Capillary"                                                                                                                                                 
[29502] "Corneoscleral_Coat"                                                                                                                                                   
[29503] "Corniculate_Cartilage"                                                                                                                                                
[29504] "Cornu_Ammonis"                                                                                                                                                        
[29505] "Corona_Dentis"                                                                                                                                                        
[29506] "Coronary_Artery_Branch"                                                                                                                                               
[29507] "Coronary_Ligament"                                                                                                                                                    
[29508] "Coronary_Sinus"                                                                                                                                                       
[29509] "Coronary_Valve"                                                                                                                                                       
[29510] "Corpora_Albicantia"                                                                                                                                                   
[29511] "Corpora_Cavernosa"                                                                                                                                                    
[29512] "Corpus_Callosum_Cistern"                                                                                                                                              
[29513] "Corpus_Spongiosum"                                                                                                                                                    
[29514] "Cortical_Arch"                                                                                                                                                        
[29515] "Cortical_Cell_Layer"                                                                                                                                                  
[29516] "Cortical_Column"                                                                                                                                                      
[29517] "Cortical_Nephron"                                                                                                                                                     
[29518] "Cortical_Vein"                                                                                                                                                        
[29519] "Corticotrope_Cell"                                                                                                                                                    
[29520] "Costal_Cartilage"                                                                                                                                                     
[29521] "Costochondral_Joint"                                                                                                                                                  
[29522] "Costophrenic_Angle"                                                                                                                                                   
[29523] "Costovertebral_Joint"                                                                                                                                                 
[29524] "Cowper_s_Gland"                                                                                                                                                       
[29525] "Cremaster_Muscle"                                                                                                                                                     
[29526] "Cricoarytenoid_Joint"                                                                                                                                                 
[29527] "Cricoarytenoid_Muscle"                                                                                                                                                
[29528] "Cricoesophageal_Tendon"                                                                                                                                               
[29529] "Cricoid_Cartilage"                                                                                                                                                    
[29530] "Cricopharyngeus_Muscle"                                                                                                                                               
[29531] "Cricothyroid_Joint"                                                                                                                                                   
[29532] "Cricothyroid_Ligament"                                                                                                                                                
[29533] "Cricothyroid_Muscle"                                                                                                                                                  
[29534] "Cricotracheal_Ligament"                                                                                                                                               
[29535] "Crossed_Pyramidal_Tract"                                                                                                                                              
[29536] "Crosslinker"                                                                                                                                                          
[29537] "Crural_Cistern"                                                                                                                                                       
[29538] "Crus_Cerebri"                                                                                                                                                         
[29539] "Crus_Helicis"                                                                                                                                                         
[29540] "Crypts_of_the_Lieberkuhn"                                                                                                                                             
[29541] "Crystal_of_Reinke"                                                                                                                                                    
[29542] "Crystalline_Inclusion"                                                                                                                                                
[29543] "Cuboid_Bone"                                                                                                                                                          
[29544] "Cuboidal_Epithelium"                                                                                                                                                  
[29545] "Cuneiform_Bone_of_the_Foot"                                                                                                                                           
[29546] "Cuneiform_Cartilage"                                                                                                                                                  
[29547] "Curved_Tube"                                                                                                                                                          
[29548] "Cutaneous_Muscle"                                                                                                                                                     
[29549] "Cymba_Conchae"                                                                                                                                                        
[29550] "Cystic_Duct"                                                                                                                                                          
[29551] "Cystic_Vein"                                                                                                                                                          
[29552] "Cytoplasmic_Inclusion"                                                                                                                                                
[29553] "Cytoplasmic_Matrix"                                                                                                                                                   
[29554] "Decidua"                                                                                                                                                              
[29555] "Decidua_Basalis"                                                                                                                                                      
[29556] "Decidua_Capsularis"                                                                                                                                                   
[29557] "Decidua_Parietalis"                                                                                                                                                   
[29558] "Decidual_Cell"                                                                                                                                                        
[29559] "Deep_Abdominal_Muscle"                                                                                                                                                
[29560] "Deep_Cervical_Lymph_Node"                                                                                                                                             
[29561] "Deep_Circumflex_Iliac_Artery"                                                                                                                                         
[29562] "Deep_Epigastric_Artery"                                                                                                                                               
[29563] "Deep_Epigastric_Vein"                                                                                                                                                 
[29564] "Deep_Fascia"                                                                                                                                                          
[29565] "Deep_Femoral_Artery"                                                                                                                                                  
[29566] "Deep_Femoral_Artery_Branch"                                                                                                                                           
[29567] "Deep_Intracranial_Venous_System"                                                                                                                                      
[29568] "Deep_Lymphatic_Vessel"                                                                                                                                                
[29569] "Deep_Middle_Cerebral_Vein"                                                                                                                                            
[29570] "Deep_Palmar_Artery"                                                                                                                                                   
[29571] "Deep_Palmar_Fascia"                                                                                                                                                   
[29572] "Deep_Palmar_Vein"                                                                                                                                                     
[29573] "Deep_Vein"                                                                                                                                                            
[29574] "Deltoid"                                                                                                                                                              
[29575] "Dendrite"                                                                                                                                                             
[29576] "Dendritic_Tree"                                                                                                                                                       
[29577] "Dendrodendritic_Synapse"                                                                                                                                              
[29578] "Dense_Connective_Tissue"                                                                                                                                              
[29579] "Dental_Pulp"                                                                                                                                                          
[29580] "Dentate_Gyrus"                                                                                                                                                        
[29581] "Dentin"                                                                                                                                                               
[29582] "Descemet_s_Membrane"                                                                                                                                                  
[29583] "Descending_Aorta"                                                                                                                                                     
[29584] "Descending_Limb_of_the_Henle_s_Loop"                                                                                                                                  
[29585] "Desmoplakin"                                                                                                                                                          
[29586] "Diagonal_Branch_of_the_Anterior_Descending_Artery"                                                                                                                    
[29587] "Diaphragma_Sellae"                                                                                                                                                    
[29588] "Diaphysis_of_the_Bone"                                                                                                                                                
[29589] "Diarthrosis"                                                                                                                                                          
[29590] "Digastric_Muscle"                                                                                                                                                     
[29591] "Dilator_Pupillae_Muscle"                                                                                                                                              
[29592] "Dimeric_Tubulin_Molecule"                                                                                                                                             
[29593] "Direct_Cerebellar_Tract"                                                                                                                                              
[29594] "Direct_Pyramidal_Tract"                                                                                                                                               
[29595] "Discontinuous_Capillary"                                                                                                                                              
[29596] "Distal_Connecting_Fiber"                                                                                                                                              
[29597] "Distal_Convoluted_Tubule"                                                                                                                                             
[29598] "Distal_Part_of_the_Lumen_of_the_Centriole"                                                                                                                            
[29599] "Dorsal_Cochlear_Nucleus"                                                                                                                                              
[29600] "Dorsal_Curve"                                                                                                                                                         
[29601] "Dorsal_Horn_of_the_Spinal_Cord"                                                                                                                                       
[29602] "Dorsal_Muscle_of_the_Back"                                                                                                                                            
[29603] "Dorsal_Nucleus_of_the_Vagus_Nerve"                                                                                                                                    
[29604] "Dorsal_Region_of_Foot"                                                                                                                                                
[29605] "Dorsal_Root_of_the_Spinal_Nerve"                                                                                                                                      
[29606] "Dorsalis_Pedis_Artery"                                                                                                                                                
[29607] "Dorsalis_Pedis_Artery_Branch"                                                                                                                                         
[29608] "Dorsomedial_Nucleus_of_the_Thalamus"                                                                                                                                  
[29609] "Dorsum"                                                                                                                                                               
[29610] "Dorsum_of_the_Tongue"                                                                                                                                                 
[29611] "Duct_of_the_Epididymis"                                                                                                                                               
[29612] "Duct_of_the_Gartner"                                                                                                                                                  
[29613] "Duct_Salivary_Gland_System"                                                                                                                                           
[29614] "Ductus_Santorini"                                                                                                                                                     
[29615] "Dura_Mater"                                                                                                                                                           
[29616] "Early_Endosome"                                                                                                                                                       
[29617] "Eccrine_Sweat_Gland"                                                                                                                                                  
[29618] "Ectocervical_Os"                                                                                                                                                      
[29619] "Efferent_Ductule"                                                                                                                                                     
[29620] "Ejaculatory_Duct"                                                                                                                                                     
[29621] "Elastic_Cartilage"                                                                                                                                                    
[29622] "Elastic_Fiber"                                                                                                                                                        
[29623] "Elastin_Fiber"                                                                                                                                                        
[29624] "Elbow_Joint"                                                                                                                                                          
[29625] "Electrical_Synapse"                                                                                                                                                   
[29626] "Electron-dense_Plasma_Membrane_Layer"                                                                                                                                 
[29627] "Electron-lucent_Plasma_Membrane_Layer"                                                                                                                                
[29628] "Electron-transport_Chain_of_the_Respiratory_Enzymes"                                                                                                                  
[29629] "Elementary_Particles"                                                                                                                                                 
[29630] "Ellipsoid_Portion_of_the_Inner_Segment_of_the_Photoreceptor_Cell"                                                                                                     
[29631] "Embryonic_Connective_Tissue"                                                                                                                                          
[29632] "Enamel"                                                                                                                                                               
[29633] "Endocrine_Cell_and_Neuroendocrine_Cell"                                                                                                                               
[29634] "Endocrine_Ovary"                                                                                                                                                      
[29635] "Endocrine_Pancreas"                                                                                                                                                   
[29636] "Endocrine_Sex_Organ"                                                                                                                                                  
[29637] "Endocrine_Testis"                                                                                                                                                     
[29638] "Endocytotic_Vesicle"                                                                                                                                                  
[29639] "Endolymph"                                                                                                                                                            
[29640] "Endometrial_Cavity"                                                                                                                                                   
[29641] "Endometrial_Cell"                                                                                                                                                     
[29642] "Endometrial_Stroma"                                                                                                                                                   
[29643] "Endomysium"                                                                                                                                                           
[29644] "Endoneurium"                                                                                                                                                          
[29645] "Endosome"                                                                                                                                                             
[29646] "Endosome_Proton"                                                                                                                                                      
[29647] "Endosteal_Cell"                                                                                                                                                       
[29648] "Endothelium_of_the_Glomerular_Capillary"                                                                                                                              
[29649] "Eparterial_Branch"                                                                                                                                                    
[29650] "Epidermal_Ridges"                                                                                                                                                     
[29651] "Epigastric_Region"                                                                                                                                                    
[29652] "Epiglottic_Cartilage"                                                                                                                                                 
[29653] "Epimysium"                                                                                                                                                            
[29654] "Epineurium"                                                                                                                                                           
[29655] "Epiphysis_of_the_Bone"                                                                                                                                                
[29656] "Epithelial_Cell_Junction"                                                                                                                                             
[29657] "Epithelial_Microvillus"                                                                                                                                               
[29658] "Epithelial_Plica"                                                                                                                                                     
[29659] "Epitympanic_Recess"                                                                                                                                                   
[29660] "Erector_Muscle_of_the_Hair"                                                                                                                                           
[29661] "Esophageal_Artery"                                                                                                                                                    
[29662] "Esophageal_Gland"                                                                                                                                                     
[29663] "Esophageal_Glandular_Cell"                                                                                                                                            
[29664] "Esophageal_Mucosa"                                                                                                                                                    
[29665] "Esophageal_Muscular_Coat"                                                                                                                                             
[29666] "Esophageal_Muscularis_Mucosa"                                                                                                                                         
[29667] "Esophageal_Opening"                                                                                                                                                   
[29668] "Esophageal_Squamous_Cell"                                                                                                                                             
[29669] "Esophageal_Tissue"                                                                                                                                                    
[29670] "Eustachian_Valve"                                                                                                                                                     
[29671] "Excitatory_Synapse"                                                                                                                                                   
[29672] "Exocrine_Pancreas"                                                                                                                                                    
[29673] "External_Abdominal_Ring"                                                                                                                                              
[29674] "External_Anal_Sphincter"                                                                                                                                              
[29675] "External_Canal"                                                                                                                                                       
[29676] "External_Capsule"                                                                                                                                                     
[29677] "External_Carotid_Artery"                                                                                                                                              
[29678] "External_Carotid_Artery_Branch"                                                                                                                                       
[29679] "External_Circumflex_Artery"                                                                                                                                           
[29680] "External_Cuneiform_Bone_of_the_Foot"                                                                                                                                  
[29681] "External_Elastic_Membrane"                                                                                                                                            
[29682] "External_Geniculate_Body"                                                                                                                                             
[29683] "External_Granular_Layer"                                                                                                                                              
[29684] "External_Iliac_Artery"                                                                                                                                                
[29685] "External_Iliac_Artery_Branch"                                                                                                                                         
[29686] "External_Iliac_Vein"                                                                                                                                                  
[29687] "External_Intercostal_Muscle"                                                                                                                                          
[29688] "External_Jugular_Vein"                                                                                                                                                
[29689] "External_Lateral_Ligament_of_the_Ankle"                                                                                                                               
[29690] "External_Maleolus"                                                                                                                                                    
[29691] "External_Malleolar_Artery"                                                                                                                                            
[29692] "External_Nose"                                                                                                                                                        
[29693] "External_Oblique_Muscle"                                                                                                                                              
[29694] "External_Parieto-occipital_Fissure"                                                                                                                                   
[29695] "External_Plantar_Artery"                                                                                                                                              
[29696] "External_Pterygoid_Muscle"                                                                                                                                            
[29697] "External_Pyramidal_Cell_Layer"                                                                                                                                        
[29698] "Extraglomerular_Mesangial_Cell"                                                                                                                                       
[29699] "Extrahepatic_Bile_Duct"                                                                                                                                               
[29700] "Eye_Appendage"                                                                                                                                                        
[29701] "Eyebrow"                                                                                                                                                              
[29702] "Eyelash"                                                                                                                                                              
[29703] "Facet_Joint"                                                                                                                                                          
[29704] "Facial_Artery"                                                                                                                                                        
[29705] "Facial_Vein"                                                                                                                                                          
[29706] "Facies_Posterior_Lentis"                                                                                                                                              
[29707] "F-actin"                                                                                                                                                              
[29708] "Falciform_Ligament"                                                                                                                                                   
[29709] "False_Vocal_Cord"                                                                                                                                                     
[29710] "Falx_Cerebelli"                                                                                                                                                       
[29711] "Fascia_Lata"                                                                                                                                                          
[29712] "Fascicle"                                                                                                                                                             
[29713] "Fasciculata_Zone"                                                                                                                                                     
[29714] "Fast-twitch_Motor_Unit"                                                                                                                                               
[29715] "Female_Genital_System_Fluid_or_Secretion"                                                                                                                             
[29716] "Female_Prepuce"                                                                                                                                                       
[29717] "Female_Urethra"                                                                                                                                                       
[29718] "Femoral_Artery_Branch"                                                                                                                                                
[29719] "Fenestra_Ovalis"                                                                                                                                                      
[29720] "Fenestra_Rotunda"                                                                                                                                                     
[29721] "Fenestrated_Capillary"                                                                                                                                                
[29722] "Fibrillin"                                                                                                                                                            
[29723] "Fibrillin_Microfibrils"                                                                                                                                               
[29724] "Fibrin"                                                                                                                                                               
[29725] "Fibrocartilage"                                                                                                                                                       
[29726] "Fibrous_Astrocyte"                                                                                                                                                    
[29727] "Fibrous_Coat_of_the_Liver"                                                                                                                                            
[29728] "Fifth_Ventricle"                                                                                                                                                      
[29729] "Filament"                                                                                                                                                             
[29730] "Filiform_Papilla"                                                                                                                                                     
[29731] "Filopodia"                                                                                                                                                            
[29732] "Fimbria"                                                                                                                                                              
[29733] "Fimbriated_End_of_the_Fallopian_tube"                                                                                                                                 
[29734] "Finger"                                                                                                                                                               
[29735] "Fingernail"                                                                                                                                                           
[29736] "First_Portion_of_the_Duodenum"                                                                                                                                        
[29737] "Fissure_of_the_Ductus_Venosus"                                                                                                                                        
[29738] "Fissure_of_the_Gallbladder"                                                                                                                                           
[29739] "Fissure_of_the_Inferior_Vena_Cava"                                                                                                                                    
[29740] "Fissure_of_Rolando"                                                                                                                                                   
[29741] "Fissure_of_Sylvius"                                                                                                                                                   
[29742] "Flat_Bone"                                                                                                                                                            
[29743] "Floor_of_the_Fourth_Ventricle"                                                                                                                                        
[29744] "Focal_Adhesion"                                                                                                                                                       
[29745] "Foliate_Papilla"                                                                                                                                                      
[29746] "Follicular_Ovarian_Cell"                                                                                                                                              
[29747] "Fontanelle"                                                                                                                                                           
[29748] "Foot"                                                                                                                                                                 
[29749] "Foot_Process"                                                                                                                                                         
[29750] "Foramen_Apicis_Dentis"                                                                                                                                                
[29751] "Foramen_of_Luschka"                                                                                                                                                   
[29752] "Foramen_of_Magendie"                                                                                                                                                  
[29753] "Foramen_of_Monroe"                                                                                                                                                    
[29754] "Forearm"                                                                                                                                                              
[29755] "Fossa_of_the_Antihelix"                                                                                                                                               
[29756] "Fossa_of_the_Helix"                                                                                                                                                   
[29757] "Fourth_Portion_of_the_Duodenum"                                                                                                                                       
[29758] "Foveolar_Cell"                                                                                                                                                        
[29759] "Free_Edge_of_the_Nail"                                                                                                                                                
[29760] "Free_Ribosome"                                                                                                                                                        
[29761] "Frontal_Bone"                                                                                                                                                         
[29762] "Frontal_Gyrus"                                                                                                                                                        
[29763] "Frontal_Horn_of_the_Lateral_Ventricle"                                                                                                                                
[29764] "Frontal_Nerve"                                                                                                                                                        
[29765] "Frontal_Sulcus"                                                                                                                                                       
[29766] "Frontopolar_Artery"                                                                                                                                                   
[29767] "FSH_Cell"                                                                                                                                                             
[29768] "Functional_Layer_of_the_Endometrium"                                                                                                                                  
[29769] "Fundic_Gland"                                                                                                                                                         
[29770] "Fungiform_Papilla"                                                                                                                                                    
[29771] "Fusiform_Cell"                                                                                                                                                        
[29772] "G-actin"                                                                                                                                                              
[29773] "Gallbladder_Body"                                                                                                                                                     
[29774] "Gallbladder_Fundus"                                                                                                                                                   
[29775] "Gallbladder_Neck"                                                                                                                                                     
[29776] "Gamma-Tubulin"                                                                                                                                                        
[29777] "Gamma-tubulin_Ring"                                                                                                                                                   
[29778] "Ganglion_Cell_Layer"                                                                                                                                                  
[29779] "Ganglionic_Layer"                                                                                                                                                     
[29780] "Gastric_Artery"                                                                                                                                                       
[29781] "Gastric_Glandular_Cell"                                                                                                                                               
[29782] "Gastric_Mucosa"                                                                                                                                                       
[29783] "Gastric_Muscular_Coat"                                                                                                                                                
[29784] "Gastric_Muscularis_Mucosa"                                                                                                                                            
[29785] "Gastric_Pit"                                                                                                                                                          
[29786] "Gastric_Rugae"                                                                                                                                                        
[29787] "Gastric_Secretion"                                                                                                                                                    
[29788] "Gastric_Serosal_Surface"                                                                                                                                              
[29789] "Gastric_Submucosa"                                                                                                                                                    
[29790] "Gastric_Tissue"                                                                                                                                                       
[29791] "Gastric_Vein"                                                                                                                                                         
[29792] "Gastrocnemius_Muscle"                                                                                                                                                 
[29793] "Gastrocolic_Ligament"                                                                                                                                                 
[29794] "Gastroesophageal_Junction"                                                                                                                                            
[29795] "Gastrointestinal_Sphincter"                                                                                                                                           
[29796] "Gastrophrenic_Ligament"                                                                                                                                               
[29797] "Gastrosplenic_Omentum"                                                                                                                                                
[29798] "G-Cell_of_the_Pancreas"                                                                                                                                               
[29799] "Geniculate_Body"                                                                                                                                                      
[29800] "Genito-urinary_Region"                                                                                                                                                
[29801] "Genu_of_the_Corpus_Callosum"                                                                                                                                          
[29802] "Germinal_Epithelium"                                                                                                                                                  
[29803] "Gingiva"                                                                                                                                                              
[29804] "Gland_of_Krause"                                                                                                                                                      
[29805] "Gland_of_Moll"                                                                                                                                                        
[29806] "Gland_of_Wolfring"                                                                                                                                                    
[29807] "Glans_Clitoris"                                                                                                                                                       
[29808] "Glenoid_Fossa"                                                                                                                                                        
[29809] "Glomerular_Basement_Membrane"                                                                                                                                         
[29810] "Glomerular_Capillary"                                                                                                                                                 
[29811] "Glomerular_Mesangial_Cell"                                                                                                                                            
[29812] "Glomeruloza_Zone"                                                                                                                                                     
[29813] "Gluteal_Artery"                                                                                                                                                       
[29814] "Glycocalyx"                                                                                                                                                           
[29815] "Glycogen_Inclusion"                                                                                                                                                   
[29816] "Gonadotrope_Cell"                                                                                                                                                     
[29817] "Graafian_Follicle"                                                                                                                                                    
[29818] "Granulosa_Lutein_Cell"                                                                                                                                                
[29819] "Gray_Commissure"                                                                                                                                                      
[29820] "Gray_Matter"                                                                                                                                                          
[29821] "Gray_Matter_of_the_Spinal_Cord"                                                                                                                                       
[29822] "Greater_Omentum"                                                                                                                                                      
[29823] "Great_Trochanter"                                                                                                                                                     
[29824] "Greater_Tuberosity"                                                                                                                                                   
[29825] "Ground_Substance"                                                                                                                                                     
[29826] "Growing_Follicle"                                                                                                                                                     
[29827] "Gyri_Breves_Insulae"                                                                                                                                                  
[29828] "Gyrus_Longus_Insulae"                                                                                                                                                 
[29829] "Hair"                                                                                                                                                                 
[29830] "Hair_Bulb"                                                                                                                                                            
[29831] "Hair_Follicle_Inferior_Segment"                                                                                                                                       
[29832] "Hair_Follicle_Infundibulum"                                                                                                                                           
[29833] "Hair_Follicle_Isthmus"                                                                                                                                                
[29834] "Hair_Papilla"                                                                                                                                                         
[29835] "Hair_Root"                                                                                                                                                            
[29836] "Hand"                                                                                                                                                                 
[29837] "Haversian_Canal"                                                                                                                                                      
[29838] "Haversian_System"                                                                                                                                                     
[29839] "Head_and_Neck_Muscle"                                                                                                                                                 
[29840] "Head_of_the_Epididymis"                                                                                                                                               
[29841] "Head_of_the_Femur"                                                                                                                                                    
[29842] "Head_of_the_Fibula"                                                                                                                                                   
[29843] "Head_of_the_Humerus"                                                                                                                                                  
[29844] "Head_of_the_Tibia"                                                                                                                                                    
[29845] "Helicotrema"                                                                                                                                                          
[29846] "Helix"                                                                                                                                                                
[29847] "Hematopoietic_Cell"                                                                                                                                                   
[29848] "Hemisphere_of_the_Cerebellum"                                                                                                                                         
[29849] "Hemispheric_Cistern"                                                                                                                                                  
[29850] "Hemorrhoidal_Plexus"                                                                                                                                                  
[29851] "Hepatic_Artery"                                                                                                                                                       
[29852] "Hepatic_Duct"                                                                                                                                                         
[29853] "Hepatic_Lobule"                                                                                                                                                       
[29854] "Hepatic_Sinusoid"                                                                                                                                                     
[29855] "Hepatic_Stellate_Cell"                                                                                                                                                
[29856] "Hepatic_Tissue"                                                                                                                                                       
[29857] "Hepatic_Vein"                                                                                                                                                         
[29858] "Hepatogastric_Ligament"                                                                                                                                               
[29859] "Herring_Body"                                                                                                                                                         
[29860] "High_Endothelial_Venule"                                                                                                                                              
[29861] "Hilar_Area_of_the_Kidney"                                                                                                                                             
[29862] "Epencephalon"                                                                                                                                                         
[29863] "Hip_Joint"                                                                                                                                                            
[29864] "Hippocampal_Fissure"                                                                                                                                                  
[29865] "Hippocampal_Sulcus"                                                                                                                                                   
[29866] "Horizontal_Cell_of_Cajal"                                                                                                                                             
[29867] "Hyaline_Cartilage"                                                                                                                                                    
[29868] "Hydatid_of_Morgani"                                                                                                                                                   
[29869] "Hydrophilic_Portion_of_the_Plasma_Membrane"                                                                                                                           
[29870] "Hydrophobic_Portion_of_the_Plasma_Membrane"                                                                                                                           
[29871] "Hymen"                                                                                                                                                                
[29872] "Hyoepiglottic_Ligament"                                                                                                                                               
[29873] "Hyoid_Bone"                                                                                                                                                           
[29874] "Hyoid_Muscle"                                                                                                                                                         
[29875] "Hyparterial_Branch"                                                                                                                                                   
[29876] "Hypogastric_Region"                                                                                                                                                   
[29877] "Hypoglossal_Triangle"                                                                                                                                                 
[29878] "Hypopharyngeal_Aspect_of_the_Aryteno-epiglottic_Fold"                                                                                                                 
[29879] "Hypophyseal_Portal_Vein"                                                                                                                                              
[29880] "Hypothalamohypophyseal_Portal_System"                                                                                                                                 
[29881] "Ileo-colic_Artery"                                                                                                                                                    
[29882] "Iliac_Lymph_Node"                                                                                                                                                     
[29883] "Iliacus"                                                                                                                                                              
[29884] "Iliocostal_Muscle"                                                                                                                                                    
[29885] "Iliopsoas_Muscle"                                                                                                                                                     
[29886] "Ilium"                                                                                                                                                                
[29887] "Immature_B-Lymphocyte"                                                                                                                                                
[29888] "Immature_Bone"                                                                                                                                                        
[29889] "Immature_Centriole"                                                                                                                                                   
[29890] "Incisor"                                                                                                                                                              
[29891] "Incus"                                                                                                                                                                
[29892] "Inferior_Anastomotic_Vein_of_the_Labbe"                                                                                                                               
[29893] "Inferior_Cerebellopontine_Cistern"                                                                                                                                    
[29894] "Inferior_External_Articular_Artery"                                                                                                                                   
[29895] "Inferior_Frontal_Convolution"                                                                                                                                         
[29896] "Inferior_Frontal_Gyrus"                                                                                                                                               
[29897] "Inferior_Frontal_Sulcus"                                                                                                                                              
[29898] "Inferior_Hypophyseal_Artery"                                                                                                                                          
[29899] "Inferior_Internal_Articular_Artery"                                                                                                                                   
[29900] "Inferior_Maxillary_Nerve"                                                                                                                                             
[29901] "Inferior_Mesenteric_Artery"                                                                                                                                           
[29902] "Inferior_Mesenteric_Artery_Branch"                                                                                                                                    
[29903] "Inferior_Mesenteric_Vein"                                                                                                                                             
[29904] "Inferior_Oblique_Muscle"                                                                                                                                              
[29905] "Inferior_Occipital_Convolution"                                                                                                                                       
[29906] "Inferior_Palpebral_Fold"                                                                                                                                              
[29907] "Inferior_Pancreatico-duodenal_artery"                                                                                                                                 
[29908] "Inferior_Parathyroid_Gland"                                                                                                                                           
[29909] "Inferior_Parietal_Convolution"                                                                                                                                        
[29910] "Inferior_Profunda_Artery"                                                                                                                                             
[29911] "Inferior_Rectus_Muscle"                                                                                                                                               
[29912] "Inferior_Temporal_Convolution"                                                                                                                                        
[29913] "Inferior_Temporal_Gyrus"                                                                                                                                              
[29914] "Inferior_Temporal_Sulcus"                                                                                                                                             
[29915] "Inferior_Turbinate"                                                                                                                                                   
[29916] "Inferior_Vena_Cava_Opening"                                                                                                                                           
[29917] "Inferior_Vermian_Artery"                                                                                                                                              
[29918] "Infraspinatus"                                                                                                                                                        
[29919] "Infratentorial_Cistern"                                                                                                                                               
[29920] "Infundibular_Cusp"                                                                                                                                                    
[29921] "Infundibular_Segment_of_the_Fallopian_Tube"                                                                                                                           
[29922] "Inguinal_Lymph_Node"                                                                                                                                                  
[29923] "Inhibitory_Synapse"                                                                                                                                                   
[29924] "Inner_Enamel_Epithelium"                                                                                                                                              
[29925] "Inner_Hair_Cell_of_the_Organ_of_the_Corti"                                                                                                                            
[29926] "Inner_Leaflet_of_the_Lipid_Bilayer"                                                                                                                                   
[29927] "Inner_Limiting_Membrane"                                                                                                                                              
[29928] "Inner_Nuclear_Layer"                                                                                                                                                  
[29929] "Inner_Plexiform_Layer"                                                                                                                                                
[29930] "Inner_Rod_of_the_Corti"                                                                                                                                               
[29931] "Inner_Segment_of_the_Photoreceptor_Cell"                                                                                                                              
[29932] "Inner_Supporting_Cell"                                                                                                                                                
[29933] "Inner_Wall_of_the_Vestibule"                                                                                                                                          
[29934] "Innominate_Artery"                                                                                                                                                    
[29935] "Innominate_Artery_Branch"                                                                                                                                             
[29936] "Innominate_Vein"                                                                                                                                                      
[29937] "Insula"                                                                                                                                                               
[29938] "Interatrial_Septum"                                                                                                                                                   
[29939] "Intercalated_Disk"                                                                                                                                                    
[29940] "Intercalated_Duct"                                                                                                                                                    
[29941] "Intercostal_Artery"                                                                                                                                                   
[29942] "Intercostal_Artery_Branch"                                                                                                                                            
[29943] "Intercostal_Fascia"                                                                                                                                                   
[29944] "Intercostal_Muscle"                                                                                                                                                   
[29945] "Intercostal_Nerve"                                                                                                                                                    
[29946] "Interlobular_Artery"                                                                                                                                                  
[29947] "Interlobular_Bile_Duct"                                                                                                                                               
[29948] "Interlobular_Duct"                                                                                                                                                    
[29949] "Intermediate_Fiber"                                                                                                                                                   
[29950] "Intermediate_Line"                                                                                                                                                    
[29951] "Intermembrane_Space_of_the_Mitochondrion"                                                                                                                             
[29952] "Internal_Abdominal_Ring"                                                                                                                                              
[29953] "Internal_Anal_Sphincter"                                                                                                                                              
[29954] "Internal_Auditory_Artery"                                                                                                                                             
[29955] "Internal_Calcanean_Artery"                                                                                                                                            
[29956] "Internal_Carotid_Artery"                                                                                                                                              
[29957] "Internal_Carotid_Artery_Branch"                                                                                                                                       
[29958] "Internal_Cerebral_Vein"                                                                                                                                               
[29959] "Internal_Circumflex_Artery"                                                                                                                                           
[29960] "Internal_Cuneiform_Bone_of_the_Foot"                                                                                                                                  
[29961] "Internal_Elastic_Membrane"                                                                                                                                            
[29962] "Internal_Geniculate_Body"                                                                                                                                             
[29963] "Internal_Granular_Layer"                                                                                                                                              
[29964] "Internal_Iliac_Artery"                                                                                                                                                
[29965] "Internal_Iliac_Artery_Branch"                                                                                                                                         
[29966] "Internal_Iliac_Vein"                                                                                                                                                  
[29967] "Internal_Intercostal_Muscle"                                                                                                                                          
[29968] "Internal_Jugular_Vein"                                                                                                                                                
[29969] "Internal_Lateral_Ligament_of_the_Ankle"                                                                                                                               
[29970] "Internal_Lumen_of_the_Centriole"                                                                                                                                      
[29971] "Internal_Malleolar_Artery"                                                                                                                                            
[29972] "Internal_Mammary_Lymph_Node"                                                                                                                                          
[29973] "Internal_Mammary_Vein"                                                                                                                                                
[29974] "Internal_Maxillary_Vein"                                                                                                                                              
[29975] "Internal_Nare"                                                                                                                                                        
[29976] "Internal_Oblique_Muscle"                                                                                                                                              
[29977] "Internal_Occipital_Vein"                                                                                                                                              
[29978] "Internal_Parieto-occipital_Fissure"                                                                                                                                   
[29979] "Internal_Plantar_Artery"                                                                                                                                              
[29980] "Internal_Pterygoid_Muscle"                                                                                                                                            
[29981] "Internal_Pubic_Artery"                                                                                                                                                
[29982] "Internal_Wall_of_the_Tympanum"                                                                                                                                        
[29983] "Interosseous_Artery"                                                                                                                                                  
[29984] "Interosseous_Vein"                                                                                                                                                    
[29985] "Interpenduncular_Cistern"                                                                                                                                             
[29986] "Interphalangeal_Joint_of_the_Foot"                                                                                                                                    
[29987] "Interphalangeal_Joint_of_the_Hand"                                                                                                                                    
[29988] "Interphase_Cell"                                                                                                                                                      
[29989] "Interstitial_Cell"                                                                                                                                                    
[29990] "Interstitial_Cell_of_Cajal"                                                                                                                                           
[29991] "Interstitial_Cell_of_the_Pineal_Gland"                                                                                                                                
[29992] "Interstitial_Segment_of_the_Fallopian_Tube"                                                                                                                           
[29993] "Interventricular_Septum"                                                                                                                                              
[29994] "Intestinal_Secretion"                                                                                                                                                 
[29995] "Intracellular_Membrane"                                                                                                                                               
[29996] "Intracranial_Venous_System"                                                                                                                                           
[29997] "Intralaminar_Nucleus"                                                                                                                                                 
[29998] "Intraparietal_Sulcus"                                                                                                                                                 
[29999] "Intra-thoracic_Lymph_Node"                                                                                                                                            
[30000] "Irregular_Bone"                                                                                                                                                       
[30001] "Irregular_Dense_Connective_Tissue"                                                                                                                                    
[30002] "Irregular_Tubule"                                                                                                                                                     
[30003] "Ischium"                                                                                                                                                              
[30004] "Islet_Cell"                                                                                                                                                           
[30005] "Isthmic_Segment_of_the_Fallopian_Tube"                                                                                                                                
[30006] "Thyroid_Gland_Isthmus"                                                                                                                                                
[30007] "Jaw_Joint"                                                                                                                                                            
[30008] "Joint_By_Site"                                                                                                                                                        
[30009] "Joint_of_the_Pelvic_Girdle"                                                                                                                                           
[30010] "Juxtaglomerular_Apparatus"                                                                                                                                            
[30011] "Juxtamedullary_Nephron"                                                                                                                                               
[30012] "Karyosome"                                                                                                                                                            
[30013] "Kidney_Lower_Lobe"                                                                                                                                                    
[30014] "Kidney_Posterior_Surface"                                                                                                                                             
[30015] "Kidney_Upper_Lobe"                                                                                                                                                    
[30016] "Kinocilium"                                                                                                                                                           
[30017] "Knee_Joint"                                                                                                                                                           
[30018] "L1_Vertebra"                                                                                                                                                          
[30019] "L2_Vertebra"                                                                                                                                                          
[30020] "L3_Vertebra"                                                                                                                                                          
[30021] "L4_Vertebra"                                                                                                                                                          
[30022] "L5_Vertebra"                                                                                                                                                          
[30023] "Labial_Salivary_Gland"                                                                                                                                                
[30024] "Lacrimal_Apparatus"                                                                                                                                                   
[30025] "Lacrimal_Bone"                                                                                                                                                        
[30026] "Lacrimal_Canaliculus"                                                                                                                                                 
[30027] "Lacrimal_Nerve"                                                                                                                                                       
[30028] "Lacrimal_Sac"                                                                                                                                                         
[30029] "Lactiferous_Duct"                                                                                                                                                     
[30030] "Lactotrope_Cell"                                                                                                                                                      
[30031] "Lamella_of_Harvesian_System"                                                                                                                                          
[30032] "Lamellar_Body"                                                                                                                                                        
[30033] "Lamellipodia"                                                                                                                                                         
[30034] "Lamina_Cinerea"                                                                                                                                                       
[30035] "Lamina_Densa"                                                                                                                                                         
[30036] "Lamina_Lucida"                                                                                                                                                        
[30037] "Lamina_Propria"                                                                                                                                                       
[30038] "Lamina_Rara_Externa"                                                                                                                                                  
[30039] "Lamina_Rara_Interna"                                                                                                                                                  
[30040] "Lamina_Spiralis_Ossea"                                                                                                                                                
[30041] "Lamina_Terminalis_Cistern"                                                                                                                                            
[30042] "Large_Cleaved_Cell"                                                                                                                                                   
[30043] "Large_Intestinal_Crypt_of_the_Lieberkuhn"                                                                                                                             
[30044] "Large_Intestinal_Glandular_Cell"                                                                                                                                      
[30045] "Large_Intestinal_Mucosa"                                                                                                                                              
[30046] "Large_Intestinal_Muscular_Coat"                                                                                                                                       
[30047] "Large_Intestinal_Muscularis_Mucosa"                                                                                                                                   
[30048] "Large_Intestinal_Serosal_Surface"                                                                                                                                     
[30049] "Large_Intestinal_Submucosa"                                                                                                                                           
[30050] "Large_Intestinal_Wall_Tissue"                                                                                                                                         
[30051] "Large_Non-cleaved_Cell"                                                                                                                                               
[30052] "Laryngeal_Ligament"                                                                                                                                                   
[30053] "Laryngeal_Muscle"                                                                                                                                                     
[30054] "Laryngeal_Ventricle"                                                                                                                                                  
[30055] "Late_Endosome"                                                                                                                                                        
[30056] "Lateral_Domain_of_the_Epithelium"                                                                                                                                     
[30057] "Lateral_Horn_of_the_Spinal_Cord"                                                                                                                                      
[30058] "Lateral_Infratentorial_Cistern"                                                                                                                                       
[30059] "Lateral_Lenticulostriate_Artery"                                                                                                                                      
[30060] "Lateral_Ligament"                                                                                                                                                     
[30061] "Lateral_Orbitofrontal_Artery"                                                                                                                                         
[30062] "Lateral_Posterior_Nucleus_of_the_Thalamus"                                                                                                                            
[30063] "Lateral_Rectus_Muscle"                                                                                                                                                
[30064] "Lateral_Sulcus_of_Sylvius"                                                                                                                                            
[30065] "Lateral_Supratentorial_Cistern"                                                                                                                                       
[30066] "Lateral_Surface_of_the_Liver"                                                                                                                                         
[30067] "Lateral_Surface_of_the_Prostate"                                                                                                                                      
[30068] "Lateral_Thyrohyoid_Ligament"                                                                                                                                          
[30069] "Lateral_Vestibular_Nucleus"                                                                                                                                           
[30070] "Lateral-occipital_Sulcus"                                                                                                                                             
[30071] "Layer_of_the_Ophthalmic_Nerve_Fibers"                                                                                                                                 
[30072] "Layer_of_the_Rods_and_Cones"                                                                                                                                          
[30073] "Left_Cerebral_Hemisphere"                                                                                                                                             
[30074] "Left_Common_Carotid_Artery"                                                                                                                                           
[30075] "Left_Common_Iliac_Artery"                                                                                                                                             
[30076] "Left_Coronary_Artery_Branch"                                                                                                                                          
[30077] "Left_Fallopian_Tube"                                                                                                                                                  
[30078] "Left_Hepatic_Duct"                                                                                                                                                    
[30079] "Left_Hypochondriac_Region"                                                                                                                                            
[30080] "Left_Inferior_Frontal_Convolution"                                                                                                                                    
[30081] "Left_Inguinal_Region"                                                                                                                                                 
[30082] "Left_Innominate_Vein"                                                                                                                                                 
[30083] "Left_Lobe_of_the_Liver"                                                                                                                                               
[30084] "Left_Lumbar_Region"                                                                                                                                                   
[30085] "Left_Lung"                                                                                                                                                            
[30086] "Left_Main_Bronchus"                                                                                                                                                   
[30087] "Left_Ovary"                                                                                                                                                           
[30088] "Left_Portion_of_the_Diaphragm"                                                                                                                                        
[30089] "Left_Pulmonary_Artery"                                                                                                                                                
[30090] "Left_Subclavian_Artery"                                                                                                                                               
[30091] "Left_Thyroid_Gland_Lobe"                                                                                                                                              
[30092] "Leg"                                                                                                                                                                  
[30093] "Lens_Capsule"                                                                                                                                                         
[30094] "Lens_Fiber"                                                                                                                                                           
[30095] "Lenticular_Nucleus"                                                                                                                                                   
[30096] "Lentiform_Nucleus"                                                                                                                                                    
[30097] "Leptomeninges"                                                                                                                                                        
[30098] "Lesser_Omentum"                                                                                                                                                       
[30099] "Lesser_Trochanter"                                                                                                                                                    
[30100] "Lesser_Tuberosity"                                                                                                                                                    
[30101] "Levator_Ani"                                                                                                                                                          
[30102] "LH_Cell"                                                                                                                                                              
[30103] "Ligamentum_Flavum"                                                                                                                                                    
[30104] "Lingual_Salivary_Gland"                                                                                                                                               
[30105] "Lingual_Tonsil"                                                                                                                                                       
[30106] "Lipid_Inclusion"                                                                                                                                                      
[30107] "Lipoblast"                                                                                                                                                            
[30108] "Lipocyte"                                                                                                                                                             
[30109] "Liver_Acinus"                                                                                                                                                         
[30110] "Liver_Acinus_Zone_1"                                                                                                                                                  
[30111] "Liver_Acinus_Zone_2"                                                                                                                                                  
[30112] "Liver_Acinus_Zone_3"                                                                                                                                                  
[30113] "Liver_Fissure"                                                                                                                                                        
[30114] "Liver_Ligament"                                                                                                                                                       
[30115] "Lobar_Bronchus"                                                                                                                                                       
[30116] "Lobule_of_the_Auricle"                                                                                                                                                
[30117] "Lobus_Caudatus"                                                                                                                                                       
[30118] "Lobus_Quadratus"                                                                                                                                                      
[30119] "Lobus_Spigelii"                                                                                                                                                       
[30120] "Long_Bone"                                                                                                                                                            
[30121] "Long_Saphenous_Vein"                                                                                                                                                  
[30122] "Longitudinal_Fissure"                                                                                                                                                 
[30123] "Loop_of_Henle"                                                                                                                                                        
[30124] "Loose_Connective_Tissue"                                                                                                                                              
[30125] "Low_Columnar_Cell"                                                                                                                                                    
[30126] "Lower_Esophageal_Sphincter"                                                                                                                                           
[30127] "Lower_Gastrointestinal_Tract"                                                                                                                                         
[30128] "Lower_Opening_of_the_Thorax"                                                                                                                                          
[30129] "Lower_Respiratory_System"                                                                                                                                             
[30130] "Lumbar_Artery"                                                                                                                                                        
[30131] "Lumbar_Curve"                                                                                                                                                         
[30132] "Lumbar_Nerve"                                                                                                                                                         
[30133] "Lumen_of_the_Endosome"                                                                                                                                                
[30134] "Lumen_of_the_Lysosome"                                                                                                                                                
[30135] "Lumen_of_the_Peroxisome"                                                                                                                                              
[30136] "Lunate_Sulcus"                                                                                                                                                        
[30137] "Lower_Lobe_of_the_Left_Lung"                                                                                                                                          
[30138] "Upper_Lobe_of_the_Left_Lung"                                                                                                                                          
[30139] "Lower_Lobe_of_the_Right_Lung"                                                                                                                                         
[30140] "Upper_Lobe_of_the_Right_Lung"                                                                                                                                         
[30141] "Lung_Tissue"                                                                                                                                                          
[30142] "Lunula"                                                                                                                                                               
[30143] "Lymph_Node_Afferent_Vessel"                                                                                                                                           
[30144] "Lymph_Node_by_Anatomic_Site"                                                                                                                                          
[30145] "Lymph_Node_Capsule"                                                                                                                                                   
[30146] "Lymph_Node_Cortex"                                                                                                                                                    
[30147] "Lymph_Node_Efferent_Vessel"                                                                                                                                           
[30148] "Lymph_Node_Hilum"                                                                                                                                                     
[30149] "Lymph_Node_Medullary_Portion"                                                                                                                                         
[30150] "Lymph_Node_Sinus"                                                                                                                                                     
[30151] "Lymph_Node_Tissue"                                                                                                                                                    
[30152] "Lymph_Node_Trabecula"                                                                                                                                                 
[30153] "Lymphatic_Capillary"                                                                                                                                                  
[30154] "Lymphatic_Vessel"                                                                                                                                                     
[30155] "Lymphoid_Follicle"                                                                                                                                                    
[30156] "Lymphokine-Activated_Natural_Killer_Cell"                                                                                                                             
[30157] "Lysosome_Proton"                                                                                                                                                      
[30158] "Macula_Densa"                                                                                                                                                         
[30159] "Macula_Lutea"                                                                                                                                                         
[30160] "Macula_of_Saccule"                                                                                                                                                    
[30161] "Macula_of_Utricle"                                                                                                                                                    
[30162] "Magendie_s_Foramen"                                                                                                                                                   
[30163] "Male_Breast"                                                                                                                                                          
[30164] "Male_Prepuce"                                                                                                                                                         
[30165] "Male_Urethra"                                                                                                                                                         
[30166] "Malleus"                                                                                                                                                              
[30167] "Mamillary_Body"                                                                                                                                                       
[30168] "Mantle_Zone"                                                                                                                                                          
[30169] "Marginal_Chromatin"                                                                                                                                                   
[30170] "Marginal_Cusp"                                                                                                                                                        
[30171] "Marginal_Zone_of_Lymph_Node"                                                                                                                                          
[30172] "Maturation-stage_Ameloblast"                                                                                                                                          
[30173] "Mature_B-Lymphocyte"                                                                                                                                                  
[30174] "Mature_Bone"                                                                                                                                                          
[30175] "Mature_Centriole"                                                                                                                                                     
[30176] "Mature_T-Lymphocyte"                                                                                                                                                  
[30177] "Mature_Thymocyte"                                                                                                                                                     
[30178] "Mechanoreceptor_Cell"                                                                                                                                                 
[30179] "Medial_Collateral_Ligament_of_the_Knee"                                                                                                                               
[30180] "Medial_Golgi"                                                                                                                                                         
[30181] "Medial_Lenticulostriate_Artery"                                                                                                                                       
[30182] "Medial_Orbitofrontal_Artery"                                                                                                                                          
[30183] "Medial_Rectus_Muscle"                                                                                                                                                 
[30184] "Medial_Vestibular_Nucleus"                                                                                                                                            
[30185] "Median_Basilic_Vein"                                                                                                                                                  
[30186] "Median_Cephalic_Vein"                                                                                                                                                 
[30187] "Median_Vein"                                                                                                                                                          
[30188] "Mediastinal_Lymph_Node"                                                                                                                                               
[30189] "Medullary_Artery"                                                                                                                                                     
[30190] "Meibomian_Gland"                                                                                                                                                      
[30191] "Membrane_of_the_Brain_or_Spinal_Cord"                                                                                                                                 
[30192] "Membrane_of_Crista"                                                                                                                                                   
[30193] "Membrane_of_the_Endosome"                                                                                                                                             
[30194] "Membrane_of_the_Golgi_Apparatus"                                                                                                                                      
[30195] "Membrane_of_the_Lysosome"                                                                                                                                             
[30196] "Membrane_of_the_Peroxisome"                                                                                                                                           
[30197] "Vestibular_Membrane"                                                                                                                                                  
[30198] "Membrane_of_the_Rough_Endoplasmic_Reticulum"                                                                                                                          
[30199] "Membrane_of_the_Smooth_Endoplasmic_Reticulum"                                                                                                                         
[30200] "Membrane-attached_Polyribosome"                                                                                                                                       
[30201] "Membrane-attached_Ribosome"                                                                                                                                           
[30202] "Membranous_Canal_of_the_Cochlea"                                                                                                                                      
[30203] "Membranous_Cytoplasmic_Organelle"                                                                                                                                     
[30204] "Membranous_Labyrinth"                                                                                                                                                 
[30205] "Membranous_Urethra"                                                                                                                                                   
[30206] "Meningeal_Layer_of_the_Dura_Mater"                                                                                                                                    
[30207] "Meningeal_Nerve"                                                                                                                                                      
[30208] "Meningothelial_Cell"                                                                                                                                                  
[30209] "Meniscus"                                                                                                                                                             
[30210] "Meniscus_Lateralis"                                                                                                                                                   
[30211] "Meniscus_Medialis"                                                                                                                                                    
[30212] "Menses"                                                                                                                                                               
[30213] "Mesangium"                                                                                                                                                            
[30214] "Mesencephalic_Perforating_Artery"                                                                                                                                     
[30215] "Mesentery"                                                                                                                                                            
[30216] "Mesothelial_Cell"                                                                                                                                                     
[30217] "Mesothelium"                                                                                                                                                          
[30218] "Metacarpophalangeal_Joint"                                                                                                                                            
[30219] "Metatarsal_Artery"                                                                                                                                                    
[30220] "Metatarsophalangeal_Joint"                                                                                                                                            
[30221] "Microcirculatory_Bed"                                                                                                                                                 
[30222] "Microtrabecular_Strand"                                                                                                                                               
[30223] "Microtubule_Triplet"                                                                                                                                                  
[30224] "Microvillus"                                                                                                                                                          
[30225] "Midcortical_Nephron"                                                                                                                                                  
[30226] "Middle_Cerebral_Artery_Branch"                                                                                                                                        
[30227] "Middle_Constrictor_Muscle"                                                                                                                                            
[30228] "Middle_Cuneiform_Bone_of_the_Foot"                                                                                                                                    
[30229] "Middle_Fossa"                                                                                                                                                         
[30230] "Middle_Frontal_Convolution"                                                                                                                                           
[30231] "Middle_Frontal_Gyrus"                                                                                                                                                 
[30232] "Middle_Hemorrhoidal_Artery"                                                                                                                                           
[30233] "Middle_Inferior_Frontal_Convolution"                                                                                                                                  
[30234] "Middle_Mediastinum"                                                                                                                                                   
[30235] "Middle_Occipital_Convolution"                                                                                                                                         
[30236] "Middle_Temporal_Convolution"                                                                                                                                          
[30237] "Middle_Temporal_Gyrus"                                                                                                                                                
[30238] "Middle_Temporal_Sulcus"                                                                                                                                               
[30239] "Middle_Thyrohyoid_Ligament"                                                                                                                                           
[30240] "Minor_Salivary_Gland"                                                                                                                                                 
[30241] "Minus_End_of_the_Actin_Filament"                                                                                                                                      
[30242] "Minus_End_of_the_Microtubule"                                                                                                                                         
[30243] "Mitochondrial_Crista"                                                                                                                                                 
[30244] "Mitochondrial_Matrix"                                                                                                                                                 
[30245] "Mitochondrial_Matrix_Granule"                                                                                                                                         
[30246] "Modiolus"                                                                                                                                                             
[30247] "Molar_Tooth"                                                                                                                                                          
[30248] "Molecular_Layer"                                                                                                                                                      
[30249] "Monocytoid_B-Cell"                                                                                                                                                    
[30250] "Mons_Pubis"                                                                                                                                                           
[30251] "Motor_Nucleus_of_the_Trigeminal_Nerve"                                                                                                                                
[30252] "Mucous_Salivary_Gland"                                                                                                                                                
[30253] "Multiform_Cell_Layer"                                                                                                                                                 
[30254] "Multipolar_Neuron"                                                                                                                                                    
[30255] "Multivesicular_Body"                                                                                                                                                  
[30256] "Muscle_and_Fasciae_of_the_Thorax"                                                                                                                                     
[30257] "Muscle_of_the_Coccyx"                                                                                                                                                 
[30258] "Muscle_of_the_Mastication"                                                                                                                                            
[30259] "Muscle_of_the_Tympanum"                                                                                                                                               
[30260] "Muscularis_Mucosa"                                                                                                                                                    
[30261] "Musculus_Latissimus_Dorsi"                                                                                                                                            
[30262] "Myoblast"                                                                                                                                                             
[30263] "Myoepithelial_Cell"                                                                                                                                                   
[30264] "Myofibroblast"                                                                                                                                                        
[30265] "Myofilament"                                                                                                                                                          
[30266] "Myoid_Portion_of_the_Inner_Segment_of_the_Photoreceptor_Cell"                                                                                                         
[30267] "Nail"                                                                                                                                                                 
[30268] "Nasal_Bone"                                                                                                                                                           
[30269] "Nasal_Muscle"                                                                                                                                                         
[30270] "Nasal_Nerve"                                                                                                                                                          
[30271] "Nasal_Septum"                                                                                                                                                         
[30272] "Nasolacrimal_Duct"                                                                                                                                                    
[30273] "Navicular_Bone"                                                                                                                                                       
[30274] "Neck_Muscle"                                                                                                                                                          
[30275] "Neck_of_the_Humerus"                                                                                                                                                  
[30276] "Nervi_Vascularis"                                                                                                                                                     
[30277] "Neural_Retina"                                                                                                                                                        
[30278] "Neurofilament-H"                                                                                                                                                      
[30279] "Neurofilament-L"                                                                                                                                                      
[30280] "Neurofilament-M"                                                                                                                                                      
[30281] "Nissl_Body"                                                                                                                                                           
[30282] "Node_of_Bizzozero"                                                                                                                                                    
[30283] "Node_of_Ranvier"                                                                                                                                                      
[30284] "Non-articular_Bone_Surface"                                                                                                                                           
[30285] "Nonmembranous_Cytoplasmic_Organelle"                                                                                                                                  
[30286] "Nonphotosensitive_Region_of_the_Retina"                                                                                                                               
[30287] "Normal_Cell"                                                                                                                                                          
[30288] "Normal_Tissue"                                                                                                                                                        
[30289] "Nostril"                                                                                                                                                              
[30290] "Nuclear_Lamin"                                                                                                                                                        
[30291] "Nucleolar-Associated_Chromatin"                                                                                                                                       
[30292] "Nucleolar_Fibrillar_Material"                                                                                                                                         
[30293] "Nucleolar_Granular_Material"                                                                                                                                          
[30294] "Nucleolonema"                                                                                                                                                         
[30295] "Nucleus_of_the_Hypoglossal_Nerve"                                                                                                                                     
[30296] "Nucleus_of_the_Mesencephalic_Tract_of_the_Trigeminal_Nerve"                                                                                                           
[30297] "Nucleus_of_the_Solitary_Tract"                                                                                                                                        
[30298] "Nucleus_of_the_Spinal_Tract_of_the_Trigeminal_Nerve"                                                                                                                  
[30299] "Nutrient_Artery"                                                                                                                                                      
[30300] "Obturator_Artery"                                                                                                                                                     
[30301] "Obturator_Externus_Muscle"                                                                                                                                            
[30302] "Obturator_Internus_Muscle"                                                                                                                                            
[30303] "Obturator_Muscle"                                                                                                                                                     
[30304] "Occipital_Artery"                                                                                                                                                     
[30305] "Occipital_Horn_of_the_Lateral_Ventricle"                                                                                                                              
[30306] "Occipital_Sulcus"                                                                                                                                                     
[30307] "Occipital-temporal_Gyrus"                                                                                                                                             
[30308] "Occipito-frontalis_Muscle"                                                                                                                                            
[30309] "Oculomotor_Muscle"                                                                                                                                                    
[30310] "Olecranon"                                                                                                                                                            
[30311] "Olfactory_Chemoreceptor"                                                                                                                                              
[30312] "Olfactory_Cistern"                                                                                                                                                    
[30313] "Olfactory_Epithelium"                                                                                                                                                 
[30314] "Olfactory_Lobe"                                                                                                                                                       
[30315] "Olfactory_Mucosa"                                                                                                                                                     
[30316] "Olfactory_Sulcus"                                                                                                                                                     
[30317] "Olfactory_Tract"                                                                                                                                                      
[30318] "Omentum"                                                                                                                                                              
[30319] "Oolemma"                                                                                                                                                              
[30320] "Ooplasm"                                                                                                                                                              
[30321] "Opening_of_the_Antrum"                                                                                                                                                
[30322] "Opening_of_the_Pulmonary_Vein"                                                                                                                                        
[30323] "Opening_of_the_Vena_Cava"                                                                                                                                             
[30324] "Ophthalmic_Nerve"                                                                                                                                                     
[30325] "Opthalmic_Artery"                                                                                                                                                     
[30326] "Optic_Commissure"                                                                                                                                                     
[30327] "Optic_Tract"                                                                                                                                                          
[30328] "Orbiculus_Ciliaris"                                                                                                                                                   
[30329] "Orbit_Disc"                                                                                                                                                           
[30330] "Orbital_Part_of_the_Inferior_Frontal_Gyrus"                                                                                                                           
[30331] "Orbital_Sulcus"                                                                                                                                                       
[30332] "Organ_of_Corti"                                                                                                                                                       
[30333] "Organ_of_the_Special_Sense"                                                                                                                                           
[30334] "Orifice_of_the_Eustachian_Tube"                                                                                                                                       
[30335] "Orthodox_Configuration_of_the_Mitochondrion"                                                                                                                          
[30336] "Osseous_Labyrinth"                                                                                                                                                    
[30337] "Osteoid"                                                                                                                                                              
[30338] "Other_Body_Part"                                                                                                                                                      
[30339] "Otolith"                                                                                                                                                              
[30340] "Otolymph"                                                                                                                                                             
[30341] "Outer_Enamel_Epithelium"                                                                                                                                              
[30342] "Outer_Hair_Cell_of_the_Organ_of_the_Corti"                                                                                                                            
[30343] "Outer_Leaflet_of_the_Lipid_Bilayer"                                                                                                                                   
[30344] "Outer_Limiting_Membrane"                                                                                                                                              
[30345] "Outer_Nuclear_Layer_of_Retina"                                                                                                                                        
[30346] "Outer_Plexiform_Layer"                                                                                                                                                
[30347] "Outer_Rod_of_the_Corti"                                                                                                                                               
[30348] "Outer_Segment_of_the_Photoreceptor_Cell"                                                                                                                              
[30349] "Outer_Supporting_Cell"                                                                                                                                                
[30350] "Outer_Wall_of_the_Vestibule"                                                                                                                                          
[30351] "Ovarian_Artery"                                                                                                                                                       
[30352] "Ovarian_Cortex"                                                                                                                                                       
[30353] "Ovarian_Follicle"                                                                                                                                                     
[30354] "Ovarian_Medulla"                                                                                                                                                      
[30355] "Ovarian_Tissue"                                                                                                                                                       
[30356] "Palatal_Muscle"                                                                                                                                                       
[30357] "Palate_Bone"                                                                                                                                                          
[30358] "Palatine_Salivary_Gland"                                                                                                                                              
[30359] "Palatine_Tonsil"                                                                                                                                                      
[30360] "Palmar_Fascia"                                                                                                                                                        
[30361] "Palmar_Region"                                                                                                                                                        
[30362] "Pancreatic_Centroacinar_Cell"                                                                                                                                         
[30363] "Pancreatic_Endocrine_Secretion"                                                                                                                                       
[30364] "Pancreatic_Exocrine_Secretion"                                                                                                                                        
[30365] "Papilla_of_the_Tongue"                                                                                                                                                
[30366] "Papillary_Muscle"                                                                                                                                                     
[30367] "Parafascicular_Nucleus_of_the_Thalamus"                                                                                                                               
[30368] "Parafollicular_Cell"                                                                                                                                                  
[30369] "Parahippocampal_Gyrus"                                                                                                                                                
[30370] "Paranasal_Sinus_Retired"                                                                                                                                              
[30371] "Paranemin"                                                                                                                                                            
[30372] "Parathyroid_Gland_Capsule"                                                                                                                                            
[30373] "Parathyroid_Gland_Chief_Cell"                                                                                                                                         
[30374] "Parathyroid_Gland_Clear_Cell"                                                                                                                                         
[30375] "Parathyroid_Gland_Follicle"                                                                                                                                           
[30376] "Parathyroid_Gland_Oxyphil_Cell"                                                                                                                                       
[30377] "Parathyroid_Gland_Tissue"                                                                                                                                             
[30378] "Parietal_Layer_of_Bowman_s_Capsule"                                                                                                                                   
[30379] "Parietal_Part_of_the_Peritoneum"                                                                                                                                      
[30380] "Parietal_Pleura"                                                                                                                                                      
[30381] "Parieto-occipital_Artery"                                                                                                                                             
[30382] "Parieto-occipital_Fissure"                                                                                                                                            
[30383] "Parieto-occipital_Sulcus"                                                                                                                                             
[30384] "Parotid_Duct"                                                                                                                                                         
[30385] "Parotid_Gland_Lymph_Node"                                                                                                                                             
[30386] "Pars_Externa"                                                                                                                                                         
[30387] "Pars_Interna"                                                                                                                                                         
[30388] "Pars_Media"                                                                                                                                                           
[30389] "Patella"                                                                                                                                                              
[30390] "Patellar_Ligament"                                                                                                                                                    
[30391] "Pectoralis_Major"                                                                                                                                                     
[30392] "Pectoralis_Minor"                                                                                                                                                     
[30393] "Pectoralis_Muscle"                                                                                                                                                    
[30394] "Pelvic_Bone"                                                                                                                                                          
[30395] "Pelvic_Curve"                                                                                                                                                         
[30396] "Pelvic_Floor_Muscle"                                                                                                                                                  
[30397] "Pelvic_Girdle"                                                                                                                                                        
[30398] "Perforating_Artery"                                                                                                                                                   
[30399] "Perforating_Canal"                                                                                                                                                    
[30400] "Periarteriolar_Lymphoid_Sheath"                                                                                                                                       
[30401] "Pericallosal_Artery"                                                                                                                                                  
[30402] "Pericardiac_Artery"                                                                                                                                                   
[30403] "Perilymph"                                                                                                                                                            
[30404] "Perimetrium"                                                                                                                                                          
[30405] "Perimysium"                                                                                                                                                           
[30406] "Perineal_Muscle"                                                                                                                                                      
[30407] "Perineum"                                                                                                                                                             
[30408] "Perineurium"                                                                                                                                                          
[30409] "Perinuclear_Cisternal_Space"                                                                                                                                          
[30410] "Periodontium"                                                                                                                                                         
[30411] "Periosteal_Cell"                                                                                                                                                      
[30412] "Periosteal_Layer_of_the_Dura_Mater"                                                                                                                                   
[30413] "Peripheral_Zone_of_the_Prostatic_Parenchyma"                                                                                                                          
[30414] "Perisinusoidal_Space"                                                                                                                                                 
[30415] "Peritoneal_Mesothelial_Cell"                                                                                                                                          
[30416] "Periurethral_Zone_of_the_Prostatic_Parenchyma"                                                                                                                        
[30417] "Perivitelline_Space"                                                                                                                                                  
[30418] "Permanent_Tooth"                                                                                                                                                      
[30419] "Peroneal_Artery"                                                                                                                                                      
[30420] "Phagolysosome"                                                                                                                                                        
[30421] "Phagosome"                                                                                                                                                            
[30422] "Phalanx"                                                                                                                                                              
[30423] "Pharyngeal_Tonsil"                                                                                                                                                    
[30424] "Photosensitive_Region_of_the_Retina"                                                                                                                                  
[30425] "Phrenic_Artery"                                                                                                                                                       
[30426] "Pia_Mater"                                                                                                                                                            
[30427] "Pillar_Cell"                                                                                                                                                          
[30428] "Pinealocyte"                                                                                                                                                          
[30429] "Pinocytotic_Vesicle"                                                                                                                                                  
[30430] "Plantar_Fascia"                                                                                                                                                       
[30431] "Plantar_Region"                                                                                                                                                       
[30432] "Plasma_Membrane_Glycolipid"                                                                                                                                           
[30433] "Plasma_Membrane_Lipid_Bilayer"                                                                                                                                        
[30434] "Platysma_Myoides"                                                                                                                                                     
[30435] "Pleural_Mesothelial_Cell"                                                                                                                                             
[30436] "Pluripotential_Bone_Marrow_Stem_Cell"                                                                                                                                 
[30437] "Plus_End_of_the_Actin_Filament"                                                                                                                                       
[30438] "Plus_End_of_the_Microtubule"                                                                                                                                          
[30439] "Podocyte"                                                                                                                                                             
[30440] "Pontine_Branch"                                                                                                                                                       
[30441] "Popliteal_Artery"                                                                                                                                                     
[30442] "Popliteal_Artery_Branch"                                                                                                                                              
[30443] "Popliteal_Vein"                                                                                                                                                       
[30444] "Popliteus_Muscle"                                                                                                                                                     
[30445] "Portal_Lobule"                                                                                                                                                        
[30446] "Portal_Triad"                                                                                                                                                         
[30447] "Portal_Vein"                                                                                                                                                          
[30448] "Portal_Venous_System"                                                                                                                                                 
[30449] "Postcapillary_Venule"                                                                                                                                                 
[30450] "Postcentral_Gyrus"                                                                                                                                                    
[30451] "Postcentral_Sulcus"                                                                                                                                                   
[30452] "Posterior_Annular_Ligament"                                                                                                                                           
[30453] "Posterior_Auricular_Vein"                                                                                                                                             
[30454] "Posterior_Carpal_Artery"                                                                                                                                              
[30455] "Posterior_Cerebral_Artery_Branch"                                                                                                                                     
[30456] "Posterior_Choroidal_Artery"                                                                                                                                           
[30457] "Posterior_Circulation_Intracranial_Artery"                                                                                                                            
[30458] "Posterior_Circumflex_Artery"                                                                                                                                          
[30459] "Posterior_Column"                                                                                                                                                     
[30460] "Posterior_Commissure"                                                                                                                                                 
[30461] "Posterior_Communicating_Artery"                                                                                                                                       
[30462] "Posterior_Cricoarytenoid_Ligament"                                                                                                                                    
[30463] "Posterior_Cruciate_Ligament"                                                                                                                                          
[30464] "Posterior_External_Jugular_Vein"                                                                                                                                      
[30465] "Posterior_Fossa"                                                                                                                                                      
[30466] "Posterior_Inferior_Cerebellar_Artery"                                                                                                                                 
[30467] "Posterior_Inferior_Frontal_Convolution"                                                                                                                               
[30468] "Posterior_Infratentorial_Cistern"                                                                                                                                     
[30469] "Posterior_Longitudinal_Ligament"                                                                                                                                      
[30470] "Posterior_Median_Fissure"                                                                                                                                             
[30471] "Posterior_Mediastinal_Artery"                                                                                                                                         
[30472] "Posterior_Mediastinum"                                                                                                                                                
[30473] "Posterior_Meningeal_Artery"                                                                                                                                           
[30474] "Posterior_Nucleus_of_the_Thalamus"                                                                                                                                    
[30475] "Posterior_Olfactory_Lobule"                                                                                                                                           
[30476] "Posterior_Parietal_Artery"                                                                                                                                            
[30477] "Posterior_Part_of_the_Ambient_Cistern"                                                                                                                                
[30478] "Posterior_Pigment_Epithelium"                                                                                                                                         
[30479] "Posterior_Pole_of_the_Lens"                                                                                                                                           
[30480] "Posterior_Portion_of_the_Corpus_Callosum_Cistern"                                                                                                                     
[30481] "Posterior_Quadrigeminal_Body"                                                                                                                                         
[30482] "Posterior_Semicircular_Canal"                                                                                                                                         
[30483] "Posterior_Supratentorial_Cistern"                                                                                                                                     
[30484] "Posterior_Surface_of_the_Liver"                                                                                                                                       
[30485] "Posterior_Surface_of_the_Stomach"                                                                                                                                     
[30486] "Posterior_Surface_of_the_Vagina"                                                                                                                                      
[30487] "Posterior_Temporal_Artery"                                                                                                                                            
[30488] "Posterior_Tibial_Artery_Branch"                                                                                                                                       
[30489] "Posterior_Tibial_Vein"                                                                                                                                                
[30490] "Posterior_Ulnar_Vein"                                                                                                                                                 
[30491] "Posterior_Wall_of_the_Tympanum"                                                                                                                                       
[30492] "Postero-lateral_Fissure"                                                                                                                                              
[30493] "Postsynaptic_Membrane"                                                                                                                                                
[30494] "Pre-B_Lymphocyte"                                                                                                                                                     
[30495] "Precentral_Artery"                                                                                                                                                    
[30496] "Precentral_Gyrus"                                                                                                                                                     
[30497] "Precentral_Sulcus"                                                                                                                                                    
[30498] "Precentral_Vermian_Vein"                                                                                                                                              
[30499] "Premedullary_Cistern"                                                                                                                                                 
[30500] "Prepontine_Cistern"                                                                                                                                                   
[30501] "Presynaptic_Knob"                                                                                                                                                     
[30502] "Pre-Thymocyte"                                                                                                                                                        
[30503] "Primordial_Follicle"                                                                                                                                                  
[30504] "Primordial_Germ_Cell"                                                                                                                                                 
[30505] "Principal_Sensory_Nucleus_of_the_Trigeminal_Nerve"                                                                                                                    
[30506] "Procentriole"                                                                                                                                                         
[30507] "Processus_Cochleariformis"                                                                                                                                            
[30508] "Promontory"                                                                                                                                                           
[30509] "Prostate_Capsule"                                                                                                                                                     
[30510] "Prostatic_Duct_Tissue"                                                                                                                                                
[30511] "Prostatic_Glandular_Cell"                                                                                                                                             
[30512] "Prostatic_Tissue"                                                                                                                                                     
[30513] "Protoplasmic_Astrocyte"                                                                                                                                               
[30514] "Proximal_Connecting_Fiber"                                                                                                                                            
[30515] "Proximal_Convoluted_Tube"                                                                                                                                             
[30516] "Proximal_Part_of_the_Lumen_of_the_Centriole"                                                                                                                          
[30517] "Pseudostratified_Epithelium"                                                                                                                                          
[30518] "Psoas_Major"                                                                                                                                                          
[30519] "Psoas_Minor"                                                                                                                                                          
[30520] "Psoas_Muscle"                                                                                                                                                         
[30521] "Pubic_Bone"                                                                                                                                                           
[30522] "Pubic_Hair"                                                                                                                                                           
[30523] "Pubic_Symphisis"                                                                                                                                                      
[30524] "Pulmonary_Acinus"                                                                                                                                                     
[30525] "Pulmonary_Artery_Branch"                                                                                                                                              
[30526] "Pulmonary_Lobule"                                                                                                                                                     
[30527] "Pupil"                                                                                                                                                                
[30528] "Purkinje_Fiber"                                                                                                                                                       
[30529] "Pyloric_Gland"                                                                                                                                                        
[30530] "Pyloric_Orifice"                                                                                                                                                      
[30531] "Pyloric_Sphincter"                                                                                                                                                    
[30532] "Pyramid"                                                                                                                                                              
[30533] "Pyramid_of_Ferrein"                                                                                                                                                   
[30534] "Pyramid_of_Malpighi"                                                                                                                                                  
[30535] "Pyramidal_Lobe"                                                                                                                                                       
[30536] "Pyramidalis"                                                                                                                                                          
[30537] "Pyriform_Sinus"                                                                                                                                                       
[30538] "Quadratus_Lumborum"                                                                                                                                                   
[30539] "Quadriceps_Muscle_of_the_Thigh"                                                                                                                                       
[30540] "Quadrigeminal_Artery"                                                                                                                                                 
[30541] "Quadrigeminal_Body"                                                                                                                                                   
[30542] "Quadrigeminal_Cistern"                                                                                                                                                
[30543] "Radial_Vein_of_the_Upper_Extremity"                                                                                                                                   
[30544] "Radix_Dentis"                                                                                                                                                         
[30545] "Recto-Vaginal_Pouch"                                                                                                                                                  
[30546] "Recto-Vesical_Pouch"                                                                                                                                                  
[30547] "Rectus_Abdominis"                                                                                                                                                     
[30548] "Recurrent_Artery_of_Heubner"                                                                                                                                          
[30549] "Red_Fiber"                                                                                                                                                            
[30550] "Refractile_Media"                                                                                                                                                     
[30551] "Regular_Dense_Connective_Tissue"                                                                                                                                      
[30552] "Renal_Afferent_Vessel"                                                                                                                                                
[30553] "Renal_Cell"                                                                                                                                                           
[30554] "Renal_Corpuscle"                                                                                                                                                      
[30555] "Renal_Efferent_Vessel"                                                                                                                                                
[30556] "Renal_Interstitial_Cell"                                                                                                                                              
[30557] "Renal_Interstitial_Tissue"                                                                                                                                            
[30558] "Renal_Papilla"                                                                                                                                                        
[30559] "Renal_Tissue"                                                                                                                                                         
[30560] "Renal_Vein"                                                                                                                                                           
[30561] "Renshaw_Cell"                                                                                                                                                         
[30562] "Reserve_Stem_Cell"                                                                                                                                                    
[30563] "Respiratory_Bronchiole"                                                                                                                                               
[30564] "Rete_Malpighii"                                                                                                                                                       
[30565] "Rete_Testis"                                                                                                                                                          
[30566] "Reticular_Fiber"                                                                                                                                                      
[30567] "Reticularis_Zone"                                                                                                                                                     
[30568] "Retinal_Pigment_Epithelium"                                                                                                                                           
[30569] "Ridge_of_the_Aqueductus_Fallopii"                                                                                                                                     
[30570] "Right_Cerebral_Hemisphere"                                                                                                                                            
[30571] "Right_Common_Carotid_Artery"                                                                                                                                          
[30572] "Right_Common_Iliac_Artery"                                                                                                                                            
[30573] "Right_Fallopian_Tube"                                                                                                                                                 
[30574] "Right_Hepatic_Duct"                                                                                                                                                   
[30575] "Right_Hypochondriac_Region"                                                                                                                                           
[30576] "Right_Inferior_Frontal_Convolution"                                                                                                                                   
[30577] "Right_Inguinal_Region"                                                                                                                                                
[30578] "Right_Innominate_Vein"                                                                                                                                                
[30579] "Right_Lobe_of_the_Liver"                                                                                                                                              
[30580] "Right_Lumbar_Region"                                                                                                                                                  
[30581] "Right_Lung"                                                                                                                                                           
[30582] "Right_Lymphatic_Duct"                                                                                                                                                 
[30583] "Right_Lymphatic_Trunk"                                                                                                                                                
[30584] "Right_Main_Bronchus"                                                                                                                                                  
[30585] "Right_Ovary"                                                                                                                                                          
[30586] "Right_Portion_of_the_Diaphragm"                                                                                                                                       
[30587] "Right_Pulmonary_Artery"                                                                                                                                               
[30588] "Right_Subclavian_Artery"                                                                                                                                              
[30589] "Right_Thyroid_Gland_Lobe"                                                                                                                                             
[30590] "Rokitansky-Aschoff_Sinus"                                                                                                                                             
[30591] "Roof_of_the_Fourth_Ventricle"                                                                                                                                         
[30592] "Root_of_the_Nail"                                                                                                                                                     
[30593] "Rostrum_of_the_Corpus_Callosum"                                                                                                                                       
[30594] "Rotator_Cuff"                                                                                                                                                         
[30595] "S1_Vertebra"                                                                                                                                                          
[30596] "S2_Vertebra"                                                                                                                                                          
[30597] "S3_Vertebra"                                                                                                                                                          
[30598] "S4_Vertebra"                                                                                                                                                          
[30599] "S5_Vertebra"                                                                                                                                                          
[30600] "Saccule"                                                                                                                                                              
[30601] "Sacral_Bone"                                                                                                                                                          
[30602] "Sacral_Nerve"                                                                                                                                                         
[30603] "Sacrococcygeal_Joint"                                                                                                                                                 
[30604] "Sacroiliac_Joint"                                                                                                                                                     
[30605] "Sacrum"                                                                                                                                                               
[30606] "Salivary_Gland_Tissue"                                                                                                                                                
[30607] "Salpingopharyngeus"                                                                                                                                                   
[30608] "Saphenous_Vein"                                                                                                                                                       
[30609] "Sarcolemma"                                                                                                                                                           
[30610] "Sarcoplasm"                                                                                                                                                           
[30611] "Sarcoplasmic_Reticulum"                                                                                                                                               
[30612] "Sartorius_Muscle"                                                                                                                                                     
[30613] "Satellite_Cell"                                                                                                                                                       
[30614] "Scalene_Muscle"                                                                                                                                                       
[30615] "Sciatic_Artery"                                                                                                                                                       
[30616] "Sebaceous_Gland"                                                                                                                                                      
[30617] "Sebaceous_Gland_Duct"                                                                                                                                                 
[30618] "Sebaceous_Gland_of_the_Eyelash"                                                                                                                                       
[30619] "Second_Portion_of_the_Duodenum"                                                                                                                                       
[30620] "Secondary_Oocyte"                                                                                                                                                     
[30621] "Secretory-stage_Ameloblast"                                                                                                                                           
[30622] "Eye_Segment"                                                                                                                                                          
[30623] "Segmental_Bronchus"                                                                                                                                                   
[30624] "Semicircular_Canal"                                                                                                                                                   
[30625] "Semicircular_Duct"                                                                                                                                                    
[30626] "Seminal_Fluid"                                                                                                                                                        
[30627] "Sensory_Hair"                                                                                                                                                         
[30628] "Sensory_Receptor_of_the_Ear"                                                                                                                                          
[30629] "Sensory-Somatic_Nervous_System"                                                                                                                                       
[30630] "Septal_Cusp"                                                                                                                                                          
[30631] "Septal_Vein"                                                                                                                                                          
[30632] "Septum_Pellucidum"                                                                                                                                                    
[30633] "Seromucous_Salivary_Gland"                                                                                                                                            
[30634] "Serosal_Surface_of_the_Liver"                                                                                                                                         
[30635] "Serous_Salivary_Gland"                                                                                                                                                
[30636] "Serratus_Magnus"                                                                                                                                                      
[30637] "Sesamoid_Bone"                                                                                                                                                        
[30638] "Sex_Chromosome"                                                                                                                                                       
[30639] "Shaft_of_the_Hair"                                                                                                                                                    
[30640] "Sheath_of_Schwann"                                                                                                                                                    
[30641] "Short_Bone"                                                                                                                                                           
[30642] "Short_Saphenous_Vein"                                                                                                                                                 
[30643] "Shoulder_Girdle"                                                                                                                                                      
[30644] "Shoulder_Joint"                                                                                                                                                       
[30645] "Sigmoid_Artery"                                                                                                                                                       
[30646] "Sigmoid_Flexure"                                                                                                                                                      
[30647] "Sigmoid_Sinus"                                                                                                                                                        
[30648] "Simple_Columnar_Epithelium"                                                                                                                                           
[30649] "Simple_Cuboidal_Epithelium"                                                                                                                                           
[30650] "Simple_Epithelium"                                                                                                                                                    
[30651] "Sinoatrial_Node"                                                                                                                                                      
[30652] "Sinus"                                                                                                                                                                
[30653] "Sinus_of_Valsava"                                                                                                                                                     
[30654] "Skeletal_Fiber"                                                                                                                                                       
[30655] "Skin_of_the_Face"                                                                                                                                                     
[30656] "Skin_Squamous_Cell"                                                                                                                                                   
[30657] "Skin_Tissue"                                                                                                                                                          
[30658] "Slow-twitch_Motor_Unit"                                                                                                                                               
[30659] "Small_Intestinal_Crypt_of_Lieberkuhn"                                                                                                                                 
[30660] "Small_Intestinal_Glandular_Cell"                                                                                                                                      
[30661] "Small_Intestinal_Goblet_Cell"                                                                                                                                         
[30662] "Small_Intestinal_Mucosa"                                                                                                                                              
[30663] "Small_Intestinal_Muscular_Coat"                                                                                                                                       
[30664] "Small_Intestinal_Muscularis_Mucosa"                                                                                                                                   
[30665] "Small_Intestinal_Serosal_Surface"                                                                                                                                     
[30666] "Small_Intestinal_Submucosa"                                                                                                                                           
[30667] "Small_Intestinal_Wall_Tissue"                                                                                                                                         
[30668] "Smegma"                                                                                                                                                               
[30669] "Soluble_Enzymes_of_the_Citric_Acid_Cycle"                                                                                                                             
[30670] "Somatotrope_Cell"                                                                                                                                                     
[30671] "Space_of_Fontana"                                                                                                                                                     
[30672] "Space_of_Mall"                                                                                                                                                        
[30673] "Spermatic_Artery"                                                                                                                                                     
[30674] "Spermatogenic_Cell"                                                                                                                                                   
[30675] "Sphenomaxillary_Fossa"                                                                                                                                                
[30676] "Sphenoparietal_Sinus"                                                                                                                                                 
[30677] "Sphincter_Pupillae_Muscle"                                                                                                                                            
[30678] "Spinal_Artery"                                                                                                                                                        
[30679] "Spinal_Cord_Column"                                                                                                                                                   
[30680] "Spinal_Cord_Fissure"                                                                                                                                                  
[30681] "Spinal_Dorsal_Nerve"                                                                                                                                                  
[30682] "Spinal_Vestibular_Nucleus"                                                                                                                                            
[30683] "Spiral_Artery"                                                                                                                                                        
[30684] "Spiral_Organ_of_Corti"                                                                                                                                                
[30685] "Spiral_Tube_of_Schchowa"                                                                                                                                              
[30686] "Splenial_Artery"                                                                                                                                                      
[30687] "Splenic_Arteriole"                                                                                                                                                    
[30688] "Splenic_Artery"                                                                                                                                                       
[30689] "Splenic_Capsule"                                                                                                                                                      
[30690] "Splenic_Cord"                                                                                                                                                         
[30691] "Splenic_Hilar_Lymph_Node"                                                                                                                                             
[30692] "Splenic_Hilum"                                                                                                                                                        
[30693] "Splenic_Lymphoid_Follicle"                                                                                                                                            
[30694] "Splenic_Pulp"                                                                                                                                                         
[30695] "Splenic_Sinus"                                                                                                                                                        
[30696] "Splenic_Trabecula"                                                                                                                                                    
[30697] "Splenic_Vein"                                                                                                                                                         
[30698] "Splenium_of_the_Corpus_Callosum"                                                                                                                                      
[30699] "Stapedius_Muscle"                                                                                                                                                     
[30700] "Stapes"                                                                                                                                                               
[30701] "Stellate_Reticulum"                                                                                                                                                   
[30702] "Stereocilium"                                                                                                                                                         
[30703] "Sternoclavicular_Joint"                                                                                                                                               
[30704] "Sternocleidomastoid_Muscle"                                                                                                                                           
[30705] "Sternocostal_Joint"                                                                                                                                                   
[30706] "Straight_Artery"                                                                                                                                                      
[30707] "Straight_Sinus"                                                                                                                                                       
[30708] "Stratified_Columnar_Epithelium"                                                                                                                                       
[30709] "Stratified_Cuboidal_Epithelium"                                                                                                                                       
[30710] "Stratified_Epithelium"                                                                                                                                                
[30711] "Stratum_Basale"                                                                                                                                                       
[30712] "Stratum_Conjunctum"                                                                                                                                                   
[30713] "Stratum_Corneum"                                                                                                                                                      
[30714] "Stratum_Disjunctum"                                                                                                                                                   
[30715] "Stratum_Granulosum"                                                                                                                                                   
[30716] "Stratum_Intermedium"                                                                                                                                                  
[30717] "Stratum_Lucidum"                                                                                                                                                      
[30718] "Stratum_Papillare"                                                                                                                                                    
[30719] "Stratum_Reticulare"                                                                                                                                                   
[30720] "Striae_Medullares"                                                                                                                                                    
[30721] "Striated_Border"                                                                                                                                                      
[30722] "Striated_Duct"                                                                                                                                                        
[30723] "Striated_Muscle_Tissue_Cell"                                                                                                                                          
[30724] "Stroma_of_the_Ovarian_Cortex"                                                                                                                                         
[30725] "Stylopharyngeus"                                                                                                                                                      
[30726] "Subarachnoid_Cistern"                                                                                                                                                 
[30727] "Subcapsular_Epithelium_of_the_Lens"                                                                                                                                   
[30728] "Lymph_Node_Subcapsular_Sinus"                                                                                                                                         
[30729] "Subclavian_Artery"                                                                                                                                                    
[30730] "Subclavius"                                                                                                                                                           
[30731] "Subcutis"                                                                                                                                                             
[30732] "Subendocardial_Layer"                                                                                                                                                 
[30733] "Subendothelial_Layer"                                                                                                                                                 
[30734] "Subiculum"                                                                                                                                                            
[30735] "Submandibular_Duct"                                                                                                                                                   
[30736] "Subscapular_Artery"                                                                                                                                                   
[30737] "Subscapularis"                                                                                                                                                        
[30738] "Substantia_Propria"                                                                                                                                                   
[30739] "Subtalar_Joint"                                                                                                                                                       
[30740] "Sulcus_Centralis"                                                                                                                                                     
[30741] "Sulcus_Centralis_Insulae"                                                                                                                                             
[30742] "Sulcus_Limitans"                                                                                                                                                      
[30743] "Sulcus_Terminalis"                                                                                                                                                    
[30744] "Superficial_Abdominal_Muscle"                                                                                                                                         
[30745] "Superficial_Cervical_Lymph_Node"                                                                                                                                      
[30746] "Superficial_Fascia"                                                                                                                                                   
[30747] "Superficial_Femoral_Artery"                                                                                                                                           
[30748] "Superficial_Intracranial_Venous_System"                                                                                                                               
[30749] "Superficial_Lymphatic_Vessel"                                                                                                                                         
[30750] "Superficial_Middle_Cerebral_Vein"                                                                                                                                     
[30751] "Superficial_Palmar_Arch"                                                                                                                                              
[30752] "Superficial_Vein"                                                                                                                                                     
[30753] "Superficial_Vein_of_the_Hand"                                                                                                                                         
[30754] "Superior_Anastomotic_Vein_of_the_Trolard"                                                                                                                             
[30755] "Superior_Cerebellar_Artery"                                                                                                                                           
[30756] "Superior_Cerebellar_Cistern"                                                                                                                                          
[30757] "Superior_Cerebellopontine_Cistern"                                                                                                                                    
[30758] "Superior_Constrictor_Muscle"                                                                                                                                          
[30759] "Superior_External_Articular_Artery"                                                                                                                                   
[30760] "Superior_Frontal_Convolution"                                                                                                                                         
[30761] "Superior_Frontal_Gyrus"                                                                                                                                               
[30762] "Superior_Frontal_Sulcus"                                                                                                                                              
[30763] "Superior_Hemorrhoidal_Artery"                                                                                                                                         
[30764] "Superior_Hypophyseal_Artery"                                                                                                                                          
[30765] "Superior_Infratentorial_Cistern"                                                                                                                                      
[30766] "Superior_Intercostal_Vein"                                                                                                                                            
[30767] "Superior_Internal_Articular_Artery"                                                                                                                                   
[30768] "Superior_Maxillary_Bone"                                                                                                                                              
[30769] "Superior_Maxillary_Nerve"                                                                                                                                             
[30770] "Superior_Mediastinum"                                                                                                                                                 
[30771] "Superior_Mesenteric_Artery"                                                                                                                                           
[30772] "Superior_Mesenteric_Artery_Branch"                                                                                                                                    
[30773] "Superior_Mesenteric_Vein"                                                                                                                                             
[30774] "Superior_Oblique_Muscle"                                                                                                                                              
[30775] "Superior_Occipital_Convolution"                                                                                                                                       
[30776] "Superior_Palpebral_Fold"                                                                                                                                              
[30777] "Superior_Parathyroid_Gland"                                                                                                                                           
[30778] "Superior_Parietal_Convolution"                                                                                                                                        
[30779] "Superior_Profunda_Artery"                                                                                                                                             
[30780] "Superior_Rectus_Muscle"                                                                                                                                               
[30781] "Superior_Semicircular_Canal"                                                                                                                                          
[30782] "Superior_Supratentorial_Cistern"                                                                                                                                      
[30783] "Superior_Surface_of_the_Liver"                                                                                                                                        
[30784] "Superior_Temporal_Convolution"                                                                                                                                        
[30785] "Superior_Temporal_Gyrus"                                                                                                                                              
[30786] "Superior_Temporal_Sulcus"                                                                                                                                             
[30787] "Superior_Thoracic_Artery"                                                                                                                                             
[30788] "Superior_Vena_Cava_Opening"                                                                                                                                           
[30789] "Superior_Vestibular_Nucleus"                                                                                                                                          
[30790] "Supporting_Cell_of_the_Nervous_System"                                                                                                                                
[30791] "Suprachorioid_Lamina"                                                                                                                                                 
[30792] "Supramarginal_Gyrus"                                                                                                                                                  
[30793] "Supra-orbital_Vein"                                                                                                                                                   
[30794] "Suprarenal_Artery"                                                                                                                                                    
[30795] "Supraspinatus"                                                                                                                                                        
[30796] "Supratentorial_Cistern"                                                                                                                                               
[30797] "Sweat_Gland"                                                                                                                                                          
[30798] "Sweat_Gland_Duct"                                                                                                                                                     
[30799] "Sylvian_Cistern"                                                                                                                                                      
[30800] "Synaptic_Cleft"                                                                                                                                                       
[30801] "Synarthrosis"                                                                                                                                                         
[30802] "Synovial_Bursa"                                                                                                                                                       
[30803] "Synovial_Fluid"                                                                                                                                                       
[30804] "Systemic_Vein"                                                                                                                                                        
[30805] "T1_Vertebra"                                                                                                                                                          
[30806] "T10_Vertebra"                                                                                                                                                         
[30807] "T11_Vertebra"                                                                                                                                                         
[30808] "T12_Vertebra"                                                                                                                                                         
[30809] "T2_Vertebra"                                                                                                                                                          
[30810] "T3_Vertebra"                                                                                                                                                          
[30811] "T4_Vertebra"                                                                                                                                                          
[30812] "T5_Vertebra"                                                                                                                                                          
[30813] "T6_Vertebra"                                                                                                                                                          
[30814] "T7_Vertebra"                                                                                                                                                          
[30815] "T8_Vertebra"                                                                                                                                                          
[30816] "T9_Vertebra"                                                                                                                                                          
[30817] "Tail_of_the_Epididymis"                                                                                                                                               
[30818] "Tail_of_the_Spermatozoon"                                                                                                                                             
[30819] "Tarsal_Artery"                                                                                                                                                        
[30820] "Tarsal_Joint"                                                                                                                                                         
[30821] "Tarsal_Plate"                                                                                                                                                         
[30822] "Tarsus_Bone"                                                                                                                                                          
[30823] "Taste_Pore"                                                                                                                                                           
[30824] "Tear"                                                                                                                                                                 
[30825] "Tectorial_Membrane"                                                                                                                                                   
[30826] "Temporal_Artery"                                                                                                                                                      
[30827] "Temporal_Fossa"                                                                                                                                                       
[30828] "Temporal_Muscle"                                                                                                                                                      
[30829] "Temporal_Sulcus"                                                                                                                                                      
[30830] "Temporary_Tooth"                                                                                                                                                      
[30831] "Temporo-maxillary_Vein"                                                                                                                                               
[30832] "Tendinocyte"                                                                                                                                                          
[30833] "Tensor_Tympani"                                                                                                                                                       
[30834] "Tentorium_Cerebelli"                                                                                                                                                  
[30835] "Teres_Major_Muscle"                                                                                                                                                   
[30836] "Teres_Minor_Muscle"                                                                                                                                                   
[30837] "Teres_Muscle"                                                                                                                                                         
[30838] "Terminal_Bar"                                                                                                                                                         
[30839] "Terminal_Bronchiole"                                                                                                                                                  
[30840] "Terminal_Bronchiole_Epithelium"                                                                                                                                       
[30841] "Terminal_Ductal_Lobular_Unit_Cell"                                                                                                                                    
[30842] "Terminal_Ileum"                                                                                                                                                       
[30843] "Testicular_Tissue"                                                                                                                                                    
[30844] "Thalamencephalon"                                                                                                                                                     
[30845] "Thalamostriate_Vein"                                                                                                                                                  
[30846] "Theca_Lutein_Cell"                                                                                                                                                    
[30847] "Thick_Filament"                                                                                                                                                       
[30848] "Thigh"                                                                                                                                                                
[30849] "Thin_Filament"                                                                                                                                                        
[30850] "Third_Portion_of_the_Duodenum"                                                                                                                                        
[30851] "Thoracic_Aorta"                                                                                                                                                       
[30852] "Thoracic_Aorta_Branch"                                                                                                                                                
[30853] "Thoracic_Duct"                                                                                                                                                        
[30854] "Thoracic_Lymph_Node"                                                                                                                                                  
[30855] "Thymic_Capsule"                                                                                                                                                       
[30856] "Thymic_Epithelial_Cell"                                                                                                                                               
[30857] "Thymic_Lobule"                                                                                                                                                        
[30858] "Thymic_Trabecula"                                                                                                                                                     
[30859] "Thymus_Cortex"                                                                                                                                                        
[30860] "Thymus_Medulla"                                                                                                                                                       
[30861] "Thyroarytenoid_Muscle"                                                                                                                                                
[30862] "Thyroepiglottic_Ligament"                                                                                                                                             
[30863] "Thyroepiglottic_Muscle"                                                                                                                                               
[30864] "Thyrohyoid_Ligament"                                                                                                                                                  
[30865] "Thyroid_Cartilage"                                                                                                                                                    
[30866] "Thyroid_Gland_Capsule"                                                                                                                                                
[30867] "Thyroid_Gland_Follicle"                                                                                                                                               
[30868] "Thyroid_Gland_Follicular_Cell"                                                                                                                                        
[30869] "Thyroid_Gland_Lobe"                                                                                                                                                   
[30870] "Thyroid_Gland_Tissue"                                                                                                                                                 
[30871] "Thyrotrope_Cell"                                                                                                                                                      
[30872] "Tibial_Vein"                                                                                                                                                          
[30873] "Toe"                                                                                                                                                                  
[30874] "Toe_Joint"                                                                                                                                                            
[30875] "Toe_Nail"                                                                                                                                                             
[30876] "Tonsillar_Crypt"                                                                                                                                                      
[30877] "Tonsillohemispheric_Artery"                                                                                                                                           
[30878] "Tooth_Cell"                                                                                                                                                           
[30879] "Tooth_Tissue"                                                                                                                                                         
[30880] "Torcular_Herophilli"                                                                                                                                                  
[30881] "Totipotent_Neuroepithelial_Stem_Cell"                                                                                                                                 
[30882] "Tracheal_Epithelium"                                                                                                                                                  
[30883] "Tract_of_Burdach"                                                                                                                                                     
[30884] "Tract_of_Goll"                                                                                                                                                        
[30885] "Tract_of_Lissauer"                                                                                                                                                    
[30886] "Tragus"                                                                                                                                                               
[30887] "Trans-Golgi_Network"                                                                                                                                                  
[30888] "Transitional_Zone_of_the_Prostatic_Parenchyma"                                                                                                                        
[30889] "Transport_Vesicle"                                                                                                                                                    
[30890] "Transversalis"                                                                                                                                                        
[30891] "Transverse_Fissure"                                                                                                                                                   
[30892] "Transverse_Rectal_Fold"                                                                                                                                               
[30893] "Transverse_Sinus"                                                                                                                                                     
[30894] "Trapezius_Muscle"                                                                                                                                                     
[30895] "Triangular_Ligament"                                                                                                                                                  
[30896] "Triangular_Part_of_the_Inferior_Frontal_Gyrus"                                                                                                                        
[30897] "Triceps"                                                                                                                                                              
[30898] "Trigonum_Olfactorium"                                                                                                                                                 
[30899] "Trochanter"                                                                                                                                                           
[30900] "True_Vocal_Cord"                                                                                                                                                      
[30901] "Trunk"                                                                                                                                                                
[30902] "Tuber_Cinereum"                                                                                                                                                       
[30903] "Tunica_Adventitia"                                                                                                                                                    
[30904] "Tunica_Albuginea"                                                                                                                                                     
[30905] "Tunica_Intima"                                                                                                                                                        
[30906] "Tunica_Media"                                                                                                                                                         
[30907] "Tunica_Vaginalis"                                                                                                                                                     
[30908] "Tunica_Vasculosa"                                                                                                                                                     
[30909] "Type_I_Epithelial_Receptor_Cell"                                                                                                                                      
[30910] "Type_II_Epithelial_Receptor_Cell"                                                                                                                                     
[30911] "Ulnar_Artery_Branch"                                                                                                                                                  
[30912] "Umbilical_Artery"                                                                                                                                                     
[30913] "Umbilical_Fissure"                                                                                                                                                    
[30914] "Umbilical_Region"                                                                                                                                                     
[30915] "Umbilical_Vein"                                                                                                                                                       
[30916] "Uncus"                                                                                                                                                                
[30917] "Undersurface_of_the_Frontal_Lobe"                                                                                                                                     
[30918] "Undersurface_of_the_Temporal_Lobe"                                                                                                                                    
[30919] "Unipolar_Neuron"                                                                                                                                                      
[30920] "Unmyelinated_Nerve_Fiber"                                                                                                                                             
[30921] "Upper_Esophageal_Sphincter"                                                                                                                                           
[30922] "Upper_Gastrointestinal_Tract"                                                                                                                                         
[30923] "Upper_Opening_of_the_Thorax"                                                                                                                                          
[30924] "Upper_Respiratory_System"                                                                                                                                             
[30925] "Urinary_Space"                                                                                                                                                        
[30926] "Urothelial_Cell"                                                                                                                                                      
[30927] "Uterine_Gland"                                                                                                                                                        
[30928] "Utero-Vesical_Pouch"                                                                                                                                                  
[30929] "Utricle"                                                                                                                                                              
[30930] "Utriculosaccular_Duct"                                                                                                                                                
[30931] "Vagal_Triangle"                                                                                                                                                       
[30932] "Vaginal_Fornix"                                                                                                                                                       
[30933] "Cardiac_Valve_Cusp"                                                                                                                                                   
[30934] "Valve_of_Kerckring"                                                                                                                                                   
[30935] "Valve_of_Vieussens"                                                                                                                                                   
[30936] "Vasa_Vasorum"                                                                                                                                                         
[30937] "Vascular_Smooth_Muscle_Tissue"                                                                                                                                        
[30938] "Vascular_System"                                                                                                                                                      
[30939] "Great_Cerebral_Vein_of_Galen"                                                                                                                                         
[30940] "Vein_of_the_Head_or_Neck"                                                                                                                                             
[30941] "Velum_Interpositum_Cistern"                                                                                                                                           
[30942] "Venous_System"                                                                                                                                                        
[30943] "Ventral_Horn_of_the_Spinal_Cord"                                                                                                                                      
[30944] "Ventral_Nerve_Root"                                                                                                                                                   
[30945] "Ventroanterior_Nucleus_of_the_Thalamus"                                                                                                                               
[30946] "Ventrolateral_Nucleus_of_the_Thalamus"                                                                                                                                
[30947] "Ventroposterior_Lateral_Nucleus_of_the_Thalamus"                                                                                                                      
[30948] "Ventroposterior_Medial_Nucleus_of_the_Thalamus"                                                                                                                       
[30949] "Vermian_Cistern"                                                                                                                                                      
[30950] "Vermis"                                                                                                                                                               
[30951] "Vertebral_Artery_Branch"                                                                                                                                              
[30952] "Vertebral_Bone"                                                                                                                                                       
[30953] "Vertebral_Canal"                                                                                                                                                      
[30954] "Vestibular_Ganglion"                                                                                                                                                  
[30955] "Vestibular_Labyrinth"                                                                                                                                                 
[30956] "Vestibule"                                                                                                                                                            
[30957] "Villus"                                                                                                                                                               
[30958] "Vimentin-like_Filament"                                                                                                                                               
[30959] "Virchow_s_Cell"                                                                                                                                                       
[30960] "Visceral_Afferent_Neuron"                                                                                                                                             
[30961] "Visceral_Efferent_Neuron"                                                                                                                                             
[30962] "Visceral_Layer_of_Bowman_s_Capsule"                                                                                                                                   
[30963] "Visceral_Part_of_the_Peritoneum"                                                                                                                                      
[30964] "Visceral_Pleura"                                                                                                                                                      
[30965] "Visceral_Striated_Muscle_Tissue"                                                                                                                                      
[30966] "Visceral_Surface_of_the_Liver"                                                                                                                                        
[30967] "Vitreous_Body"                                                                                                                                                        
[30968] "Vitreous_Chamber"                                                                                                                                                     
[30969] "Vocalis_Muscle"                                                                                                                                                       
[30970] "Voltage-dependent_Anion_Channel"                                                                                                                                      
[30971] "Vomer"                                                                                                                                                                
[30972] "White_Adipose_Tissue"                                                                                                                                                 
[30973] "White_Commissure"                                                                                                                                                     
[30974] "White_Fiber"                                                                                                                                                          
[30975] "White_Matter"                                                                                                                                                         
[30976] "White_Matter_of_the_Spinal_Cord"                                                                                                                                      
[30977] "Wrist_Joint"                                                                                                                                                          
[30978] "Xiphoid_Process"                                                                                                                                                      
[30979] "Zona_Pellucida"                                                                                                                                                       
[30980] "Zygomatic_Arch"                                                                                                                                                       
[30981] "Zygomatic_Fossa"                                                                                                                                                      
[30982] "Purdue_Pegboard_Test"                                                                                                                                                 
[30983] "Graviola"                                                                                                                                                             
[30984] "Agent_Orange"                                                                                                                                                         
[30985] "Mouse_Ovarian_Serous_Adenocarcinoma"                                                                                                                                  
[30986] "Other_Anatomic_Concept"                                                                                                                                               
[30987] "Membrane_Associated_Protein-17kDa"                                                                                                                                    
[30988] "Minichromosome_Maintenance_Protein-10"                                                                                                                                
[30989] "DNA_Replication_Licensing_Factor-MCM4"                                                                                                                                
[30990] "DNA_Replication_Licensing_Factor-MCM5"                                                                                                                                
[30991] "DNA_Replication_Licensing_Factor-MCM6"                                                                                                                                
[30992] "DNA_Replication_Licensing_Factor-MCM7"                                                                                                                                
[30993] "MCT-1_Protein"                                                                                                                                                        
[30994] "Endocervical_Columnar_Cell"                                                                                                                                           
[30995] "Ectocervical_Squamous_Cell"                                                                                                                                           
[30996] "Reserve_Cell"                                                                                                                                                         
[30997] "Trophoblastic_Cell"                                                                                                                                                   
[30998] "Syncytiotrophoblast"                                                                                                                                                  
[30999] "Cytotrophoblast"                                                                                                                                                      
[31000] "Intermediate_Trophoblast"                                                                                                                                             
[31001] "Endometrial_Stromal_Cell"                                                                                                                                             
[31002] "Mucinous_Bronchial_Cell"                                                                                                                                              
[31003] "Glandular_Cell"                                                                                                                                                       
[31004] "Ductal_Epithelial_Cell_Retired"                                                                                                                                       
[31005] "Thyroid_Gland_Oxyphil_Cell"                                                                                                                                           
[31006] "B-Prolymphocyte"                                                                                                                                                      
[31007] "T-Prolymphocyte"                                                                                                                                                      
[31008] "Left_Colon"                                                                                                                                                           
[31009] "T-Lymphoblast"                                                                                                                                                        
[31010] "B-Lymphoblast"                                                                                                                                                        
[31011] "Endoderm_Cell"                                                                                                                                                        
[31012] "Yolk_Cell"                                                                                                                                                            
[31013] "Angioblast"                                                                                                                                                           
[31014] "Ectoderm_Cell"                                                                                                                                                        
[31015] "Mesoderm_Cell"                                                                                                                                                        
[31016] "Neural_Crest_Cell"                                                                                                                                                    
[31017] "MED6_Homolog_Protein"                                                                                                                                                 
[31018] "MASL1_Protein"                                                                                                                                                        
[31019] "Matrix_Gla_Protein"                                                                                                                                                   
[31020] "ENL_Protein"                                                                                                                                                          
[31021] "AF-4_Protein"                                                                                                                                                         
[31022] "AF-9_Protein"                                                                                                                                                         
[31023] "AF-6_Protein"                                                                                                                                                         
[31024] "AF-17_Protein"                                                                                                                                                        
[31025] "Forkhead_Box_Protein-O4_Protein"                                                                                                                                      
[31026] "Palmitoylated_Membrane_Protein-1"                                                                                                                                     
[31027] "_1q23_3"                                                                                                                                                              
[31028] "Myelin_Protein_Zero-Like-1_Protein"                                                                                                                                   
[31029] "Thymic_Tissue"                                                                                                                                                        
[31030] "Virosome"                                                                                                                                                             
[31031] "RAS-Related_Protein-MRAS"                                                                                                                                             
[31032] "Mature_T-Cell_Proliferation-1_Protein"                                                                                                                                
[31033] "MYB_Binding_Protein-1A"                                                                                                                                               
[31034] "Eyelid_Part"                                                                                                                                                          
[31035] "Lacrimal_Apparatus_Part"                                                                                                                                              
[31036] "N33_Protein"                                                                                                                                                          
[31037] "Neuroblastoma-Amplified_Protein"                                                                                                                                      
[31038] "NCK_Adaptor_Protein-2"                                                                                                                                                
[31039] "DNA-Binding_Transcriptional_Activator-NCYM"                                                                                                                           
[31040] "N-Myc_Downstream_Regulated_Protein-1"                                                                                                                                 
[31041] "Central_Nervous_System_Part"                                                                                                                                          
[31042] "Neuralized-Like_Protein"                                                                                                                                              
[31043] "Peripheral_Nervous_System_Part"                                                                                                                                       
[31044] "Spinal_Cord_Part"                                                                                                                                                     
[31045] "Homeobox_Protein-NK2_Homolog-H"                                                                                                                                       
[31046] "Homeobox_Protein-NKX3A"                                                                                                                                               
[31047] "Putative_Transmembrane_Protein-NMA"                                                                                                                                   
[31048] "Cell_Surface"                                                                                                                                                         
[31049] "Neuromedin-U_Protein"                                                                                                                                                 
[31050] "Notch_Homolog-1_Protein"                                                                                                                                              
[31051] "Neuro-Oncological_Ventral_Antigen-2"                                                                                                                                  
[31052] "Natriuretic_Peptide_Receptor-B"                                                                                                                                       
[31053] "NR1_Protein"                                                                                                                                                          
[31054] "Nuclear_Receptor_Binding_Protein"                                                                                                                                     
[31055] "Neuropilin-1_Protein"                                                                                                                                                 
[31056] "Netrin-1_Protein"                                                                                                                                                     
[31057] "Neurotrophic_Tyrosine_Kinase_Receptor_Type-2"                                                                                                                         
[31058] "Neurotrophic_Tyrosine_Kinase_Receptor_Type-3"                                                                                                                         
[31059] "Nuclear_Mitotic_Apparatus_Protein-1"                                                                                                                                  
[31060] "Nucleoporin-214kDa"                                                                                                                                                   
[31061] "PEG-Interferon_Alfa-2a"                                                                                                                                               
[31062] "Megakaryocyte-Associated_Tyrosine_Kinase"                                                                                                                             
[31063] "Endocervical_Mucosa"                                                                                                                                                  
[31064] "Ectocervical_Mucosa"                                                                                                                                                  
[31065] "MAP-Kinase_Interacting_Kinase-1"                                                                                                                                      
[31066] "Melan-A_Protein"                                                                                                                                                      
[31067] "ALL1-Related_Protein"                                                                                                                                                 
[31068] "Palmitoylated_Membrane_Protein-2"                                                                                                                                     
[31069] "Palmitoylated_Membrane_Protein-3"                                                                                                                                     
[31070] "Nuclear_Receptor_Coactivator-5"                                                                                                                                       
[31071] "Nuclear_Receptor_Coactivator-6"                                                                                                                                       
[31072] "Neogenin_Homolog-1_Protein"                                                                                                                                           
[31073] "Orphan_Nuclear_Receptor-SHP"                                                                                                                                          
[31074] "Neuronal_Cell_Adhesion_Molecule"                                                                                                                                      
[31075] "Neurotrophin-3_Protein"                                                                                                                                               
[31076] "Hypochondrial_Region"                                                                                                                                                 
[31077] "Lumbar_Region"                                                                                                                                                        
[31078] "Right_Kidney"                                                                                                                                                         
[31079] "Left_Kidney"                                                                                                                                                          
[31080] "Fossa"                                                                                                                                                                
[31081] "Round_Ligament_of_the_Liver"                                                                                                                                          
[31082] "Round_Ligament_of_the_Uterus"                                                                                                                                         
[31083] "Olfactory_Receptor-1G1"                                                                                                                                               
[31084] "Origin_Recognition_Complex_Subunit-1"                                                                                                                                 
[31085] "Radial_Artery_of_the_Upper_Extremity"                                                                                                                                 
[31086] "Radial_Artery_of_the_Endometrium"                                                                                                                                     
[31087] "Origin_Recognition_Complex_Subunit-2"                                                                                                                                 
[31088] "Origin_Recognition_Complex_Subunit-3"                                                                                                                                 
[31089] "Origin_Recognition_Complex_Subunit-4"                                                                                                                                 
[31090] "Origin_Recognition_Complex_Subunit-5"                                                                                                                                 
[31091] "Origin_Recognition_Complex_Subunit-6"                                                                                                                                 
[31092] "Oncostatin-M_Specific_Receptor_Beta_Subunit"                                                                                                                          
[31093] "Nuclear_LIM_Interactor-Interacting_Factor-2"                                                                                                                          
[31094] "Lung_Lobe"                                                                                                                                                            
[31095] "Anatomic_Surface"                                                                                                                                                     
[31096] "Posterior_Surface_of_the_Kidney"                                                                                                                                      
[31097] "Phosphatidylinositol-4-Phosphate-5-Kinase_Type-II_Alpha"                                                                                                              
[31098] "Phosphatidylinositol-4-Phosphate-5-Kinase_Type-II_Beta"                                                                                                               
[31099] "Placental_TGF-Beta"                                                                                                                                                   
[31100] "Aortic_Segment"                                                                                                                                                       
[31101] "Kidney_Part"                                                                                                                                                          
[31102] "Mediastinum_Part"                                                                                                                                                     
[31103] "Organ_Capsule"                                                                                                                                                        
[31104] "Mouse_Pancreatic_Disorder"                                                                                                                                            
[31105] "Immunoblast"                                                                                                                                                          
[31106] "B-Immunoblast"                                                                                                                                                        
[31107] "T-Immunoblast"                                                                                                                                                        
[31108] "Mouse_Pancreatic_Neoplasm"                                                                                                                                            
[31109] "Mouse_Pancreatic_Acinar_Neoplasm"                                                                                                                                     
[31110] "Benign_Mouse_Pancreatic_Neoplasm"                                                                                                                                     
[31111] "Mouse_Acinar_Cell_Adenoma"                                                                                                                                            
[31112] "Mouse_Mixed_Acinar_Islet_Cell_Adenoma"                                                                                                                                
[31113] "Malignant_Mouse_Pancreatic_Neoplasm"                                                                                                                                  
[31114] "Mouse_Pancreatic_Ductal_Adenocarcinoma"                                                                                                                               
[31115] "Mouse_Acinar_Cell_Adenocarcinoma"                                                                                                                                     
[31116] "Mouse_Islet_Cell_Carcinoma"                                                                                                                                           
[31117] "Mouse_Islet_Cell_Adenocarcinoma"                                                                                                                                      
[31118] "Mouse_Pancreatic_Intraepithelial_Neoplasia-1"                                                                                                                         
[31119] "Mouse_Pancreatic_Intraepithelial_Neoplasia-1B"                                                                                                                        
[31120] "Mouse_Pancreatic_Intraepithelial_Neoplasia-2"                                                                                                                         
[31121] "Mouse_Pancreatic_Intraepithelial_Neoplasia-3"                                                                                                                         
[31122] "Mouse_Islet_Cell_Neoplasm"                                                                                                                                            
[31123] "Mouse_Islet_Cell_Adenoma"                                                                                                                                             
[31124] "Mouse_Somatostatinoma"                                                                                                                                                
[31125] "Mouse_Insulinoma"                                                                                                                                                     
[31126] "Mouse_Glucagonoma"                                                                                                                                                    
[31127] "Extraembryonic_Structure"                                                                                                                                             
[31128] "Mouse_Pancreatic_Intraepithelial_Neoplasia-1A"                                                                                                                        
[31129] "Gastrula"                                                                                                                                                             
[31130] "Trilaminar_Embryonic_Disc"                                                                                                                                            
[31131] "Embryonic_Urogenital_System"                                                                                                                                          
[31132] "Autonomic_Nervous_System_Part"                                                                                                                                        
[31133] "Reproductive_System_Part"                                                                                                                                             
[31134] "Exocrine_Gland_Fluid_or_Secretion"                                                                                                                                    
[31135] "Phospholipase-A2_Group-IIA"                                                                                                                                           
[31136] "Pleiomorphic_Adenoma-Like_Protein-1"                                                                                                                                  
[31137] "Phospholipase-C_Beta-3"                                                                                                                                               
[31138] "RBP2-Like_Protein"                                                                                                                                                    
[31139] "Immediate-Early-Response_Protein-APR"                                                                                                                                 
[31140] "Tripartite_Motif_Protein-TRIM19"                                                                                                                                      
[31141] "Postmeiotic_Segregation_Increased-2-Like_Protein-1"                                                                                                                   
[31142] "Cell_Part"                                                                                                                                                            
[31143] "DNA-Directed_RNA_Polymerase-II_Polypeptide-A"                                                                                                                         
[31144] "Polymerization"                                                                                                                                                       
[31145] "L-Type_Amino_Acid_Transporter-3"                                                                                                                                      
[31146] "Phosphatidic_Acid_Phosphatase_Type-2A"                                                                                                                                
[31147] "Skeletal_System_Part"                                                                                                                                                 
[31148] "Peroxisome_Proliferative_Activated_Receptor_Gamma"                                                                                                                    
[31149] "Protein_Serine-Threonine_Phosphatase"                                                                                                                                 
[31150] "Protein_Phosphatase-1_Catalytic_Subunit_Alpha"                                                                                                                        
[31151] "Protein_Phosphatase-2_Catalytic_Subunit_Alpha"                                                                                                                        
[31152] "Protein_Phosphatase-2_Catalytic_Subunit_Beta"                                                                                                                         
[31153] "Gastrointestinal_Tract"                                                                                                                                               
[31154] "Protein_Phosphatase_Regulatory_Protein"                                                                                                                               
[31155] "Protein_Phosphatase-2_Regulatory_Subunit-A_Beta"                                                                                                                      
[31156] "Protein_Phosphatase-2A_Regulatory_Subunit-PR53"                                                                                                                       
[31157] "Splenic_Tissue"                                                                                                                                                       
[31158] "Protein_Phosphatase-2_Regulatory_Subunit-B_Alpha"                                                                                                                     
[31159] "Protein_Phosphatase-2_Regulatory_Subunit-B_Beta"                                                                                                                      
[31160] "Protein_Phosphatase-2_Regulatory_Subunit-B_Gamma"                                                                                                                     
[31161] "Protein_Phosphatase-2_Regulatory_Subunit-B_Delta"                                                                                                                     
[31162] "Protein_Phosphatase-2_Regulatory_Subunit-B_Epsilon"                                                                                                                   
[31163] "PR-Domain_Zinc_Finger_Protein-1"                                                                                                                                      
[31164] "PR-Domain_Zinc_Finger_Protein-4"                                                                                                                                      
[31165] "Type-II_cGMP-Dependent_Protein_Kinase"                                                                                                                                
[31166] "Interferon-Inducible_elF2Alpha_Kinase"                                                                                                                                
[31167] "Transcriptional_Coactivator-p52"                                                                                                                                      
[31168] "Transcriptional_Coactivator-p75"                                                                                                                                      
[31169] "Patched_Homolog-2_Protein"                                                                                                                                            
[31170] "PTK6_Protein_Tyrosine_Kinase-6"                                                                                                                                       
[31171] "Embryonic"                                                                                                                                                            
[31172] "Allantois"                                                                                                                                                            
[31173] "Amniotic_Cavity"                                                                                                                                                      
[31174] "Amniotic_Sac"                                                                                                                                                         
[31175] "Amniotic_Surface_of_the_Placenta"                                                                                                                                     
[31176] "Anal_Membrane"                                                                                                                                                        
[31177] "Angioblastic_Cord"                                                                                                                                                    
[31178] "Anocutaneous_Line"                                                                                                                                                    
[31179] "Anterior_Cardinal_Vein"                                                                                                                                               
[31180] "Apical_Ectodermal_Ridge"                                                                                                                                              
[31181] "Auricular_Hillock"                                                                                                                                                    
[31182] "Basal_Plate"                                                                                                                                                          
[31183] "Bilaminar_Embryonic_Disc"                                                                                                                                             
[31184] "Blood_Island"                                                                                                                                                         
[31185] "Bulbus_Cordis"                                                                                                                                                        
[31186] "Cardiac_Jelly"                                                                                                                                                        
[31187] "Cardinal_Vein"                                                                                                                                                        
[31188] "Caudal_Ridge"                                                                                                                                                         
[31189] "Cecal_Diverticulum"                                                                                                                                                   
[31190] "Central_Tendon_of_the_Diaphragm"                                                                                                                                      
[31191] "Chondrification_Center"                                                                                                                                               
[31192] "Chondrocranium"                                                                                                                                                       
[31193] "Chorion"                                                                                                                                                              
[31194] "Chorionic_Plate"                                                                                                                                                      
[31195] "Chorionic_Sac"                                                                                                                                                        
[31196] "Chorionic_Villus"                                                                                                                                                     
[31197] "Chyle_Cistern"                                                                                                                                                        
[31198] "Cloaca"                                                                                                                                                               
[31199] "Cloacal_Membrane"                                                                                                                                                     
[31200] "Cloacal_Sphincter"                                                                                                                                                    
[31201] "Common_Cardinal_Vein"                                                                                                                                                 
[31202] "Conceptus"                                                                                                                                                            
[31203] "Connecting_Stalk"                                                                                                                                                     
[31204] "Connective_Tissue_of_Villus"                                                                                                                                          
[31205] "Cortical_Cord"                                                                                                                                                        
[31206] "Cotyledon"                                                                                                                                                            
[31207] "Cranial_Ridge"                                                                                                                                                        
[31208] "Cytotrophoblastic_Shell"                                                                                                                                              
[31209] "Dental_Sac"                                                                                                                                                           
[31210] "Dermatome_Region"                                                                                                                                                     
[31211] "Dermomyotome"                                                                                                                                                         
[31212] "Digital_Ray"                                                                                                                                                          
[31213] "Dorsal_Mesogastrium"                                                                                                                                                  
[31214] "Ductus_Venosus"                                                                                                                                                       
[31215] "Embryologic_Structure_or_System"                                                                                                                                      
[31216] "Embryonic_Artery"                                                                                                                                                     
[31217] "Embryonic_Atrium"                                                                                                                                                     
[31218] "Embryonic_Body_Cavity"                                                                                                                                                
[31219] "Embryonic_Cardiovascular_System"                                                                                                                                      
[31220] "Embryonic_Digestive_System"                                                                                                                                           
[31221] "Embryonic_Disc"                                                                                                                                                       
[31222] "Embryonic_Ear"                                                                                                                                                        
[31223] "Embryonic_Eye"                                                                                                                                                        
[31224] "Embryonic_Heart"                                                                                                                                                      
[31225] "Embryonic_Integumentary_System"                                                                                                                                       
[31226] "Embryonic_Muskuloskeletal_System"                                                                                                                                     
[31227] "Embryonic_Nervous_System"                                                                                                                                             
[31228] "Embryonic_Palate"                                                                                                                                                     
[31229] "Embryonic_Respiratory_System"                                                                                                                                         
[31230] "Embryonic_Vein"                                                                                                                                                       
[31231] "Embryonic_Ventricle"                                                                                                                                                  
[31232] "Endocardial_Heart_Tube"                                                                                                                                               
[31233] "Endothelium_of_the_Fetal_Capillary"                                                                                                                                   
[31234] "Epaxial_Division_of_the_Myotome"                                                                                                                                      
[31235] "Epiblast"                                                                                                                                                             
[31236] "Extraembryonic_Coelom"                                                                                                                                                
[31237] "Fetal_Gastrointestinal_Tract"                                                                                                                                         
[31238] "Fetal_Heart"                                                                                                                                                          
[31239] "Fetal_Kidney"                                                                                                                                                         
[31240] "Fetal_Liver"                                                                                                                                                          
[31241] "Fetal_Lung"                                                                                                                                                           
[31242] "Fetal_Skeleton"                                                                                                                                                       
[31243] "Fetal_Skull"                                                                                                                                                          
[31244] "Fetal_Spleen"                                                                                                                                                         
[31245] "Fifth_Pharyngeal_Pouch"                                                                                                                                               
[31246] "First_Pharyngeal_Arch"                                                                                                                                                
[31247] "First_Pharyngeal_Pouch"                                                                                                                                               
[31248] "Foot_Plate"                                                                                                                                                           
[31249] "Foramen_Primum"                                                                                                                                                       
[31250] "Foramen_Secundum"                                                                                                                                                     
[31251] "Foregut"                                                                                                                                                              
[31252] "Fourth_Pharyngeal_Pouch"                                                                                                                                              
[31253] "Frontonasal_Prominence"                                                                                                                                               
[31254] "Gonadal_Cord"                                                                                                                                                         
[31255] "Gonadal_Ridge"                                                                                                                                                        
[31256] "Hand_Plate"                                                                                                                                                           
[31257] "Hepatic_Cord"                                                                                                                                                         
[31258] "Hepatic_Diverticulum"                                                                                                                                                 
[31259] "Hindgut"                                                                                                                                                              
[31260] "Hypaxial_Division_of_the_Myotome"                                                                                                                                     
[31261] "Hypoblast"                                                                                                                                                            
[31262] "Iliac_Lymph_Sac"                                                                                                                                                      
[31263] "Indifferent_Gonad"                                                                                                                                                    
[31264] "Intermediate_Mesoderm"                                                                                                                                                
[31265] "Interventricular_Foramen"                                                                                                                                             
[31266] "Intraembryonic_Coelom"                                                                                                                                                
[31267] "Jugular_Lymph_Sac"                                                                                                                                                    
[31268] "Lanugo"                                                                                                                                                               
[31269] "Laryngotracheal_Tube"                                                                                                                                                 
[31270] "Lateral_Mesoderm"                                                                                                                                                     
[31271] "Left_Brachiocephalic_Vein"                                                                                                                                            
[31272] "Lens_Pit"                                                                                                                                                             
[31273] "Lens_Placodes"                                                                                                                                                        
[31274] "Limb_Bud"                                                                                                                                                             
[31275] "Mandibular_Prominence"                                                                                                                                                
[31276] "Maxillary_Artery"                                                                                                                                                     
[31277] "Maxillary_Prominence"                                                                                                                                                 
[31278] "Metanephric_Diverticulum"                                                                                                                                             
[31279] "Metanephric_Mass_of_the_Intermediate_Mesoderm"                                                                                                                        
[31280] "Metanephros"                                                                                                                                                          
[31281] "Midgut"                                                                                                                                                               
[31282] "Midgut_Loop"                                                                                                                                                          
[31283] "Morula"                                                                                                                                                               
[31284] "Mucous_Connective_Tissue"                                                                                                                                             
[31285] "Myotome_Region"                                                                                                                                                       
[31286] "Nail_Fold"                                                                                                                                                            
[31287] "Nail_Plate"                                                                                                                                                           
[31288] "Nasal_Prominence"                                                                                                                                                     
[31289] "Nasolacrimal_Groove"                                                                                                                                                  
[31290] "Nephrogenic_Cord"                                                                                                                                                     
[31291] "Nerve_of_the_Pharyngeal_Arch"                                                                                                                                         
[31292] "Neural_Canal"                                                                                                                                                         
[31293] "Neural_Crest"                                                                                                                                                         
[31294] "Neural_Fold"                                                                                                                                                          
[31295] "Neural_Groove"                                                                                                                                                        
[31296] "Neural_Plate"                                                                                                                                                         
[31297] "Neural_Tube"                                                                                                                                                          
[31298] "Neurenteric_Canal"                                                                                                                                                    
[31299] "Neuroectoderm"                                                                                                                                                        
[31300] "Neurula"                                                                                                                                                              
[31301] "Notochordal_Canal"                                                                                                                                                    
[31302] "Notochordal_Plate"                                                                                                                                                    
[31303] "Notochordal_Process"                                                                                                                                                  
[31304] "Optic_Cup"                                                                                                                                                            
[31305] "Optic_Groove"                                                                                                                                                         
[31306] "Optic_Stalk"                                                                                                                                                          
[31307] "Optic_Vesicle"                                                                                                                                                        
[31308] "Other_Embryologic_Structure"                                                                                                                                          
[31309] "Otic_Pit"                                                                                                                                                             
[31310] "Otic_Placodes"                                                                                                                                                        
[31311] "Otic_Vesicle"                                                                                                                                                         
[31312] "Oval_Foramen"                                                                                                                                                         
[31313] "Pancreatic_Bud"                                                                                                                                                       
[31314] "Parachordal_Cartilage"                                                                                                                                                
[31315] "Paraxial_Mesoderm"                                                                                                                                                    
[31316] "Pectinate_Line"                                                                                                                                                       
[31317] "Pericardioperitoneal_Canal"                                                                                                                                           
[31318] "Periderm"                                                                                                                                                             
[31319] "Pharyngeal_Apparatus"                                                                                                                                                 
[31320] "Pharyngeal_Arch"                                                                                                                                                      
[31321] "Pharyngeal_Groove"                                                                                                                                                    
[31322] "Pharyngeal_Membrane"                                                                                                                                                  
[31323] "Pharyngeal_Pouch"                                                                                                                                                     
[31324] "Placental_Membrane"                                                                                                                                                   
[31325] "Placental_Septum"                                                                                                                                                     
[31326] "Pleuropericardial_Membrane"                                                                                                                                           
[31327] "Pleuroperitoneal_Membrane"                                                                                                                                            
[31328] "Posterior_Cardinal_Vein"                                                                                                                                              
[31329] "Primordial_Uteroplacental_Circulation"                                                                                                                                
[31330] "Primary_Brain_Vesicle"                                                                                                                                                
[31331] "Primary_Bronchial_Bud"                                                                                                                                                
[31332] "Primary_Chorionic_Villus"                                                                                                                                             
[31333] "Primary_Lymph_Sac"                                                                                                                                                    
[31334] "Primary_Ossification_Center"                                                                                                                                          
[31335] "Primary_Palate"                                                                                                                                                       
[31336] "Primitive_Groove"                                                                                                                                                     
[31337] "Primitive_Node"                                                                                                                                                       
[31338] "Primitive_Pit"                                                                                                                                                        
[31339] "Primordial_Gut"                                                                                                                                                       
[31340] "Primordial_Interventricular_Septum"                                                                                                                                   
[31341] "Primordial_Laryngeal_Inlet"                                                                                                                                           
[31342] "Primordial_Mediastinum"                                                                                                                                               
[31343] "Primordial_Myocardium"                                                                                                                                                
[31344] "Primordial_Optic_Nerve"                                                                                                                                               
[31345] "Primordial_Phallus"                                                                                                                                                   
[31346] "Primordium"                                                                                                                                                           
[31347] "Primordium_of_the_Heart"                                                                                                                                              
[31348] "Primordium_of_the_Liver"                                                                                                                                              
[31349] "Proctodeum"                                                                                                                                                           
[31350] "Pronephric_Duct"                                                                                                                                                      
[31351] "Pronephros"                                                                                                                                                           
[31352] "Rathke_s_Pouch"                                                                                                                                                       
[31353] "Respiratory_Diverticulum"                                                                                                                                             
[31354] "Respiratory_Primordium"                                                                                                                                               
[31355] "Retinal_Fissure"                                                                                                                                                      
[31356] "Retroperitoneal_Lymph_Sac"                                                                                                                                            
[31357] "Scalp_Vascular_Plexus"                                                                                                                                                
[31358] "Sclerotome"                                                                                                                                                           
[31359] "Second_Pharyngeal_Arch"                                                                                                                                               
[31360] "Second_Pharyngeal_Pouch"                                                                                                                                              
[31361] "Secondary_Brain_Vesicle"                                                                                                                                              
[31362] "Secondary_Chorionic_Villus"                                                                                                                                           
[31363] "Secondary_Palate"                                                                                                                                                     
[31364] "Seminiferous_Cord"                                                                                                                                                    
[31365] "Septum_Primum"                                                                                                                                                        
[31366] "Septum_Secundum"                                                                                                                                                      
[31367] "Septum_Transversum"                                                                                                                                                   
[31368] "Sinovaginal_Bulb"                                                                                                                                                     
[31369] "Sinus_Tubercle"                                                                                                                                                       
[31370] "Sinus_Venarum"                                                                                                                                                        
[31371] "Sinus_Venosus"                                                                                                                                                        
[31372] "Somatopleure"                                                                                                                                                         
[31373] "Somite"                                                                                                                                                               
[31374] "Splanchnopleure"                                                                                                                                                      
[31375] "Stapedial_Artery"                                                                                                                                                     
[31376] "Stomach_Primordium"                                                                                                                                                   
[31377] "Stomodeum"                                                                                                                                                            
[31378] "Subcardinal_Vein"                                                                                                                                                     
[31379] "Supracardinal_Vein"                                                                                                                                                   
[31380] "Surface_Ectoderm"                                                                                                                                                     
[31381] "Tertiary_Chorionic_Villus"                                                                                                                                            
[31382] "Third_Pharyngeal_Pouch"                                                                                                                                               
[31383] "Thyroid_Primordium"                                                                                                                                                   
[31384] "Tooth_Bud"                                                                                                                                                            
[31385] "Tracheal_Bud"                                                                                                                                                         
[31386] "Tracheoesophageal_Fold"                                                                                                                                               
[31387] "Tracheoesophageal_Septum"                                                                                                                                             
[31388] "Trancus_Arteriosus"                                                                                                                                                   
[31389] "Tubotympanic_Recess"                                                                                                                                                  
[31390] "Umbilical_Blood"                                                                                                                                                      
[31391] "Umbilical_Cord"                                                                                                                                                       
[31392] "Urogenital_Ridge"                                                                                                                                                     
[31393] "Urogenital_Sinus"                                                                                                                                                     
[31394] "Urorectal_Septum"                                                                                                                                                     
[31395] "Uterovaginal_Primordium"                                                                                                                                              
[31396] "Vaginal_Plate"                                                                                                                                                        
[31397] "Valve_of_the_Oval_Foramen"                                                                                                                                            
[31398] "Ventral_Mesogastrium"                                                                                                                                                 
[31399] "Vernix_Caseosa"                                                                                                                                                       
[31400] "Vitelline_Vein"                                                                                                                                                       
[31401] "PTK7_Protein_Tyrosine_Kinase-7"                                                                                                                                       
[31402] "Abdominal_Cramp"                                                                                                                                                      
[31403] "Abdominal_Injury"                                                                                                                                                     
[31404] "Abdominal_Mass"                                                                                                                                                       
[31405] "Abnormal_Hard_Tissue_Formation_in_Pulp"                                                                                                                               
[31406] "Spontaneous_Abortion"                                                                                                                                                 
[31407] "Illegal_Abortion"                                                                                                                                                     
[31408] "Therapeutic_Abortion"                                                                                                                                                 
[31409] "Legally_Induced_Abortion"                                                                                                                                             
[31410] "Accident"                                                                                                                                                             
[31411] "Aircraft_Accident"                                                                                                                                                    
[31412] "Domestic_Accident"                                                                                                                                                    
[31413] "Industrial_Accident"                                                                                                                                                  
[31414] "Automobile_Accident"                                                                                                                                                  
[31415] "Achondroplasia"                                                                                                                                                       
[31416] "Acne_Keloid"                                                                                                                                                          
[31417] "Acquired_Coagulation_Factor_Deficiency"                                                                                                                               
[31418] "Acrocephalosyndactyly"                                                                                                                                                
[31419] "Actinomycetoma"                                                                                                                                                       
[31420] "Actinomycosis"                                                                                                                                                        
[31421] "Cervicofacial_Actinomycotic_Infection"                                                                                                                                
[31422] "Acute_Alcoholic_Hepatitis"                                                                                                                                            
[31423] "Acute_Atopic_Conjunctivitis"                                                                                                                                          
[31424] "Acute_Periodontitis"                                                                                                                                                  
[31425] "Acute_Pharyngitis"                                                                                                                                                    
[31426] "Acute_Intestinal_Ischemia"                                                                                                                                            
[31427] "Holmes-Adie_Syndrome"                                                                                                                                                 
[31428] "Adjustment_Reaction_with_Brief_Depressive_Reaction"                                                                                                                   
[31429] "Adnexitis"                                                                                                                                                            
[31430] "Congenital_Adrenal_Hyperplasia"                                                                                                                                       
[31431] "Affective_Psychosis"                                                                                                                                                  
[31432] "Agoraphobia"                                                                                                                                                          
[31433] "Agoraphobia_without_a_History_of_Panic_Disorder"                                                                                                                      
[31434] "Air_Sickness"                                                                                                                                                         
[31435] "Alastrim"                                                                                                                                                             
[31436] "Alcohol-Induced_Wernicke-Korsakoff_s_Syndrome"                                                                                                                        
[31437] "Alcohol_Intoxication"                                                                                                                                                 
[31438] "Alpha_Thalassemia"                                                                                                                                                    
[31439] "Extrinsic_Allergic_Alveolitis"                                                                                                                                        
[31440] "Amelia"                                                                                                                                                               
[31441] "Ametropia"                                                                                                                                                            
[31442] "Retrograde_Amnesia"                                                                                                                                                   
[31443] "Amyotrophic_Lateral_Sclerosis"                                                                                                                                        
[31444] "Ancylostomiasis_due_to_Ancylostoma_Duodenale"                                                                                                                         
[31445] "Thalassemia_Major"                                                                                                                                                    
[31446] "Hemolytic_Anemia"                                                                                                                                                     
[31447] "Acquired_Hemolytic_Anemia"                                                                                                                                            
[31448] "Autoimmune_Hemolytic_Anemia"                                                                                                                                          
[31449] "Hereditary_Hemolytic_Anemia"                                                                                                                                          
[31450] "Hypochromic_Anemia"                                                                                                                                                   
[31451] "Macrocytic_Anemia"                                                                                                                                                    
[31452] "Megaloblastic_Anemia"                                                                                                                                                 
[31453] "Sickle_Cell_Disease"                                                                                                                                                  
[31454] "Anemia_due_to_Disorder_of_Glutathione_Metabolism"                                                                                                                     
[31455] "Anhidrosis"                                                                                                                                                           
[31456] "Anomia"                                                                                                                                                               
[31457] "Anorexia_Nervosa"                                                                                                                                                     
[31458] "Anovulation"                                                                                                                                                          
[31459] "Anthracosilicosis"                                                                                                                                                    
[31460] "Coal_Miner_s_Pneumoconiosis"                                                                                                                                          
[31461] "Aortic_Arch_Syndrome"                                                                                                                                                 
[31462] "Aphakia"                                                                                                                                                              
[31463] "Aphasia"                                                                                                                                                              
[31464] "Broca_s_Aphasia"                                                                                                                                                      
[31465] "Arthropod-Born_Hemorrhagic_Fever"                                                                                                                                     
[31466] "Arthropod-Born_Viral_Infection"                                                                                                                                       
[31467] "Arm_Pain"                                                                                                                                                             
[31468] "Arteriosclerosis"                                                                                                                                                     
[31469] "Arteritis"                                                                                                                                                            
[31470] "Arthus_Reaction"                                                                                                                                                      
[31471] "Aschoff_Body"                                                                                                                                                         
[31472] "Peritoneal_Effusion"                                                                                                                                                  
[31473] "Arteriosclerotic_Cardiovascular_Disease"                                                                                                                              
[31474] "Aseptic_Necrosis_of_Head_and_Neck_of_Femur"                                                                                                                           
[31475] "Sports_Injury"                                                                                                                                                        
[31476] "Avitaminosis"                                                                                                                                                         
[31477] "Back_Injury"                                                                                                                                                          
[31478] "Background_Diabetic_Retinopathy"                                                                                                                                      
[31479] "Bagassosis"                                                                                                                                                           
[31480] "Baritosis"                                                                                                                                                            
[31481] "Cervicocranial_Syndrome"                                                                                                                                              
[31482] "Bartter_s_Syndrome"                                                                                                                                                   
[31483] "Basilar_Artery_Syndrome"                                                                                                                                              
[31484] "Basophilia"                                                                                                                                                           
[31485] "Beckwith-Wiedemann_Syndrome"                                                                                                                                          
[31486] "Behcet_s_Syndrome"                                                                                                                                                    
[31487] "Benign_Neoplasm_of_Lower_Jaw_Bone"                                                                                                                                    
[31488] "Beri_Beri"                                                                                                                                                            
[31489] "Berry_Aneurysm"                                                                                                                                                       
[31490] "Extrahepatic_Cholestasis"                                                                                                                                             
[31491] "Biliary_Atresia"                                                                                                                                                      
[31492] "Binocular_Vision_Disorder"                                                                                                                                            
[31493] "Bipolar_Disorder"                                                                                                                                                     
[31494] "Bipolar_Depression"                                                                                                                                                   
[31495] "Bird_Fancier_s_Lung"                                                                                                                                                  
[31496] "Blackwater_Fever"                                                                                                                                                     
[31497] "Blast_Injury"                                                                                                                                                         
[31498] "Blastomycosis"                                                                                                                                                        
[31499] "North_American_Blastomycosis"                                                                                                                                         
[31500] "Blepharoconjunctivitis"                                                                                                                                               
[31501] "Blind_Loop_Syndrome"                                                                                                                                                  
[31502] "Bone_Development_Disorder"                                                                                                                                            
[31503] "Bone_Marrow_Disorder"                                                                                                                                                 
[31504] "Bonnevie-Ullrich_Syndrome"                                                                                                                                            
[31505] "Chronic_Encephalopathy"                                                                                                                                               
[31506] "Retinal_Arterial_Branch_Occlusion"                                                                                                                                    
[31507] "Breast_Swelling"                                                                                                                                                      
[31508] "Breech_Presentation"                                                                                                                                                  
[31509] "Bronchospasm"                                                                                                                                                         
[31510] "Bulimia"                                                                                                                                                              
[31511] "Burn"                                                                                                                                                                 
[31512] "Chemical_Burn"                                                                                                                                                        
[31513] "Gallbladder_Stone"                                                                                                                                                    
[31514] "Chronic_Mucocutaneous_Candidiasis"                                                                                                                                    
[31515] "Cannabis_Dependence"                                                                                                                                                  
[31516] "Capgras_Syndrome"                                                                                                                                                     
[31517] "Head_and_Neck_Squamous_Cell_Carcinoma"                                                                                                                                
[31518] "Carcinosarcoma"                                                                                                                                                       
[31519] "Hypertrophic_Cardiomyopathy"                                                                                                                                          
[31520] "Carpal_Tunnel_Syndrome"                                                                                                                                               
[31521] "Car_Sickness"                                                                                                                                                         
[31522] "Catalepsy"                                                                                                                                                            
[31523] "Cauda_Equina_Syndrome_with_Neurogenic_Bladder"                                                                                                                        
[31524] "Cellulitis_of_Hand"                                                                                                                                                   
[31525] "Central_Opacity_of_Cornea"                                                                                                                                            
[31526] "Central_Retinal_Artery_Occlusion"                                                                                                                                     
[31527] "Cutaneous_Schistosomiasis"                                                                                                                                            
[31528] "Intracranial_Aneurysm"                                                                                                                                                
[31529] "Cerebral_Atherosclerosis"                                                                                                                                             
[31530] "Cerebral_Palsy"                                                                                                                                                       
[31531] "Cerebrospinal_Fluid_Otorrhea"                                                                                                                                         
[31532] "Cardiomyopathy_in_Chagas_Disease"                                                                                                                                     
[31533] "Chlamydial_Infection"                                                                                                                                                 
[31534] "Chronic_Non-Suppurative_Destructive_Cholangitis"                                                                                                                      
[31535] "Cholecystitis"                                                                                                                                                        
[31536] "Cartilage_Development_Disorder"                                                                                                                                       
[31537] "Synovial_Chondromatosis"                                                                                                                                              
[31538] "Choroid_Disorder"                                                                                                                                                     
[31539] "Choroideremia"                                                                                                                                                        
[31540] "Chromosome_Disorder"                                                                                                                                                  
[31541] "Chronic_Eosinophilic_Pneumonia"                                                                                                                                       
[31542] "Chronic_Ethmoidal_Sinusitis"                                                                                                                                          
[31543] "Chronic_Frontal_Sinusitis"                                                                                                                                            
[31544] "Chronic_Gingivitis"                                                                                                                                                   
[31545] "Chronic_Glomerulonephritis_with_Lesion_of_Membranous_Glomerulonephritis"                                                                                              
[31546] "Chronic_Iridocyclitis"                                                                                                                                                
[31547] "Chronic_Maxillary_Sinusitis"                                                                                                                                          
[31548] "Chronic_Pulmonary_Heart_Disease"                                                                                                                                      
[31549] "Chronic_Rhinitis"                                                                                                                                                     
[31550] "Chronic_Sphenoidal_Sinusitis"                                                                                                                                         
[31551] "Churg-Strauss_Syndrome"                                                                                                                                               
[31552] "Chylous_Ascites"                                                                                                                                                      
[31553] "Scar"                                                                                                                                                                 
[31554] "Clonus"                                                                                                                                                               
[31555] "Closed_Dislocation_of_Hip"                                                                                                                                            
[31556] "Closed_Dislocation_of_Shoulder"                                                                                                                                       
[31557] "Closed_Dislocation_Multiple_and_Ill-Defined_Sites"                                                                                                                    
[31558] "Closed_Fracture_of_Carpal_Bone"                                                                                                                                       
[31559] "Closed_Fracture_of_Malar_and_Maxillary_Bone"                                                                                                                          
[31560] "Closed_Fracture_of_Mandible"                                                                                                                                          
[31561] "Clubbing_of_Fingers"                                                                                                                                                  
[31562] "Cocaine_Dependence"                                                                                                                                                   
[31563] "Coccidiosis"                                                                                                                                                          
[31564] "Colic"                                                                                                                                                                
[31565] "Closed_Colles_Fracture"                                                                                                                                               
[31566] "Defective_Color_Vision"                                                                                                                                               
[31567] "Coma"                                                                                                                                                                 
[31568] "Combat_Neurosis"                                                                                                                                                      
[31569] "Common_Bile_Duct_Stone"                                                                                                                                               
[31570] "Acute_Nasopharyngitis"                                                                                                                                                
[31571] "Communicating_Hydrocephalus"                                                                                                                                          
[31572] "Congenital_Spondylolysis_Lumbosacral_Region"                                                                                                                          
[31573] "Xerophthalmia"                                                                                                                                                        
[31574] "Conjunctivitis"                                                                                                                                                       
[31575] "Acute_Hemorrhagic_Conjunctivitis"                                                                                                                                     
[31576] "Atopic_Conjunctivitis"                                                                                                                                                
[31577] "Giant_Papillary_Conjunctivitis"                                                                                                                                       
[31578] "Vernal_Conjunctivitis"                                                                                                                                                
[31579] "Viral_Conjunctivitis"                                                                                                                                                 
[31580] "Conn_s_Syndrome"                                                                                                                                                      
[31581] "Coprophagia"                                                                                                                                                          
[31582] "Hereditary_Corneal_Dystrophy"                                                                                                                                         
[31583] "Corneal_Dystrophy"                                                                                                                                                    
[31584] "Corn"                                                                                                                                                                 
[31585] "Coronary_Vasospasm"                                                                                                                                                   
[31586] "Corpus_Luteum_Cyst"                                                                                                                                                   
[31587] "Limb_Cramp"                                                                                                                                                           
[31588] "Cri_du_Chat_Syndrome"                                                                                                                                                 
[31589] "Cystic_Endometrial_Hyperplasia"                                                                                                                                       
[31590] "Cysticercosis"                                                                                                                                                        
[31591] "Dacryocystitis"                                                                                                                                                       
[31592] "Multi-infarct_Dementia"                                                                                                                                               
[31593] "Pre-senile_Dementia"                                                                                                                                                  
[31594] "Senile_Dementia"                                                                                                                                                      
[31595] "Vascular_Dementia"                                                                                                                                                    
[31596] "Demyelinating_Disorder_of_Central_Nervous_System"                                                                                                                     
[31597] "Demyelinating_Disorder"                                                                                                                                               
[31598] "Dengue_Fever"                                                                                                                                                         
[31599] "Enamel_Hypoplasia"                                                                                                                                                    
[31600] "Dental_Pulp_Disorder"                                                                                                                                                 
[31601] "Amyloid_Deposition"                                                                                                                                                   
[31602] "Endogenous_Depression"                                                                                                                                                
[31603] "Reactive_Depression"                                                                                                                                                  
[31604] "Dermatitis_due_to_Food_taken_Internally"                                                                                                                              
[31605] "Dermatophytosis_of_Groin_and_Perianal_Area"                                                                                                                           
[31606] "Dermatophytosis_of_Scalp_and_Beard"                                                                                                                                   
[31607] "Lipoatrophic_Diabetes_Mellitus"                                                                                                                                       
[31608] "Diabetic_Retinopathy"                                                                                                                                                 
[31609] "Digitalis_Toxicity"                                                                                                                                                   
[31610] "Dipetalonemiasis"                                                                                                                                                     
[31611] "Diphtheria"                                                                                                                                                           
[31612] "Anterior_Nasal_Diphtheria"                                                                                                                                            
[31613] "Pseudomembranous_Diphtheritic_Conjunctivitis"                                                                                                                         
[31614] "Cutaneous_Diphtheria"                                                                                                                                                 
[31615] "Faucial_Diphtheria"                                                                                                                                                   
[31616] "Laryngeal_Diphtheria"                                                                                                                                                 
[31617] "Nasopharyngeal_Diphtheria"                                                                                                                                            
[31618] "Fluid_Discharge"                                                                                                                                                      
[31619] "Disturbance_of_Skin_Sensation"                                                                                                                                        
[31620] "Colonic_Diverticulum"                                                                                                                                                 
[31621] "Colonic_Diverticulosis"                                                                                                                                               
[31622] "Dry_Eye_Syndrome"                                                                                                                                                     
[31623] "Dwarfism"                                                                                                                                                             
[31624] "Pituitary_Dwarfism"                                                                                                                                                   
[31625] "Dyschondroplasia"                                                                                                                                                     
[31626] "Skin_Pigmentation_Disorder"                                                                                                                                           
[31627] "Amebic_Colitis"                                                                                                                                                       
[31628] "Dysmenorrhea"                                                                                                                                                         
[31629] "Dysostosis"                                                                                                                                                           
[31630] "Dyspnea_Paroxysmal_Nocturnal"                                                                                                                                         
[31631] "Dysthymic_Disorder"                                                                                                                                                   
[31632] "Dystonia"                                                                                                                                                             
[31633] "Idiopathic_Torsion_Dystonia"                                                                                                                                          
[31634] "Vulvar_Dystrophy"                                                                                                                                                     
[31635] "Congenital_Ectopic_Lens"                                                                                                                                              
[31636] "Ectromelia"                                                                                                                                                           
[31637] "Ehlers-Danlos_Syndrome"                                                                                                                                               
[31638] "Elephantiasis"                                                                                                                                                        
[31639] "Emaciation"                                                                                                                                                           
[31640] "Interstitial_Emphysema"                                                                                                                                               
[31641] "Empyema"                                                                                                                                                              
[31642] "Empyema_with_Fistula"                                                                                                                                                 
[31643] "Pulmonary_Empyema"                                                                                                                                                    
[31644] "Tuberculous_Empyema"                                                                                                                                                  
[31645] "Epidemic_Encephalitis"                                                                                                                                                
[31646] "Japanese_B_Encephalitis"                                                                                                                                              
[31647] "Acute_Disseminated_Encephalomyelitis"                                                                                                                                 
[31648] "Tick-born_Viral_Encephalitis"                                                                                                                                         
[31649] "Encephalomyelitis"                                                                                                                                                    
[31650] "Endarteritis"                                                                                                                                                         
[31651] "Endocarditis"                                                                                                                                                         
[31652] "Subacute_Bacterial_Endocarditis"                                                                                                                                      
[31653] "Endocervical_Polyp"                                                                                                                                                   
[31654] "Endomyocardial_Fibrosis"                                                                                                                                              
[31655] "Endophthalmitis"                                                                                                                                                      
[31656] "Parasitic_Endophthalmitis"                                                                                                                                            
[31657] "Enuresis"                                                                                                                                                             
[31658] "Epicondylitis"                                                                                                                                                        
[31659] "Epidemic_Keratoconjunctivitis"                                                                                                                                        
[31660] "Erythematosquamous_Dermatosis"                                                                                                                                        
[31661] "Erythroid_Hyperplasia"                                                                                                                                                
[31662] "Erythromelalgia"                                                                                                                                                      
[31663] "Escherichia_Coli_Infection"                                                                                                                                           
[31664] "Esophageal_Stricture"                                                                                                                                                 
[31665] "Internal_Strabismus"                                                                                                                                                  
[31666] "Ethmoidal_Sinusitis"                                                                                                                                                  
[31667] "Euphoria"                                                                                                                                                             
[31668] "Excoriation"                                                                                                                                                          
[31669] "Exercise-Induced_Bronchospasm"                                                                                                                                        
[31670] "Divergent_Strabismus"                                                                                                                                                 
[31671] "Ocular_Injury"                                                                                                                                                        
[31672] "Face_Injury"                                                                                                                                                          
[31673] "Farmer_s_Lung"                                                                                                                                                        
[31674] "Fasciculation"                                                                                                                                                        
[31675] "Favism"                                                                                                                                                               
[31676] "Fever_of_Unknown_Origin"                                                                                                                                              
[31677] "Fibrous_Dysplasia_of_Bone"                                                                                                                                            
[31678] "Polyostotic_Fibrous_Dysplasia_of_Bone"                                                                                                                                
[31679] "Filariasis"                                                                                                                                                           
[31680] "Mansonella_Ozzardi_Infection"                                                                                                                                         
[31681] "Finger_Injury"                                                                                                                                                        
[31682] "Intestinal_Fistula_excluding_Rectum_and_Anus"                                                                                                                         
[31683] "Flank_Pain"                                                                                                                                                           
[31684] "Flat_Foot"                                                                                                                                                            
[31685] "Follicular_Cyst_of_Ovary"                                                                                                                                             
[31686] "Foot_Pain"                                                                                                                                                            
[31687] "Patent_Foramen_Ovale"                                                                                                                                                 
[31688] "Foreign_Body"                                                                                                                                                         
[31689] "Foreign_Body_Granuloma_of_Muscle"                                                                                                                                     
[31690] "Foreign_Body_in_Gastrointestinal_Tract"                                                                                                                               
[31691] "Closed_Fracture"                                                                                                                                                      
[31692] "Open_Fracture"                                                                                                                                                        
[31693] "Frohlich_s_Syndrome"                                                                                                                                                  
[31694] "Frontal_Sinusitis"                                                                                                                                                    
[31695] "Frostbite"                                                                                                                                                            
[31696] "Nonorganic_Enuresis"                                                                                                                                                  
[31697] "Furunculosis"                                                                                                                                                         
[31698] "Gagging"                                                                                                                                                              
[31699] "Gallbladder_Disorder"                                                                                                                                                 
[31700] "Gastroenteritis"                                                                                                                                                      
[31701] "Gastrointestinal_Malfunction_Arising_from_Mental_Factor"                                                                                                              
[31702] "Congenital_Leucocyte_Anomaly"                                                                                                                                         
[31703] "Gingival_Pocket"                                                                                                                                                      
[31704] "Gingivitis"                                                                                                                                                           
[31705] "Necrotizing_Ulcerative_Gingivitis"                                                                                                                                    
[31706] "Glanders"                                                                                                                                                             
[31707] "Angle_Closure_Glaucoma"                                                                                                                                               
[31708] "Primary_Angle_Closure_Glaucoma"                                                                                                                                       
[31709] "Open_Angle_Glaucoma"                                                                                                                                                  
[31710] "Globus_Hystericus"                                                                                                                                                    
[31711] "IgA_Nephropathy"                                                                                                                                                      
[31712] "Membranoproliferative_Glomerulonephritis"                                                                                                                             
[31713] "Membranous_Glomerulonephritis"                                                                                                                                        
[31714] "Glucose_Intolerance"                                                                                                                                                  
[31715] "Non-toxic_Nodular_Goiter"                                                                                                                                             
[31716] "Acute_Gonococcal_Infection_of_Lower_Genitourinary_Tract"                                                                                                              
[31717] "Goodpasture_Syndrome"                                                                                                                                                 
[31718] "Gout"                                                                                                                                                                 
[31719] "Granular_Corneal_Dystrophy"                                                                                                                                           
[31720] "Granulation_Tissue"                                                                                                                                                   
[31721] "Granulomatous_Arteritis"                                                                                                                                              
[31722] "Hemophilus_Infection"                                                                                                                                                 
[31723] "Hemophilus_Influenza_Infection"                                                                                                                                       
[31724] "Hair_Disorder"                                                                                                                                                        
[31725] "Hallucinogen_Dependence"                                                                                                                                              
[31726] "Hallux_Valgus"                                                                                                                                                        
[31727] "Hand_Injury"                                                                                                                                                          
[31728] "Head_Injury"                                                                                                                                                          
[31729] "Headache"                                                                                                                                                             
[31730] "Central_Hearing_Loss"                                                                                                                                                 
[31731] "High_Frequency_Hearing_Loss"                                                                                                                                          
[31732] "Noise_Induced_Hearing_Loss"                                                                                                                                           
[31733] "Heart_Block"                                                                                                                                                          
[31734] "Heart_Malformation"                                                                                                                                                   
[31735] "Cardiac_Rupture"                                                                                                                                                      
[31736] "Post_Infarct_Cardiac_Rupture"                                                                                                                                         
[31737] "Heartburn"                                                                                                                                                            
[31738] "Heberden_s_Node"                                                                                                                                                      
[31739] "Heinz_Body"                                                                                                                                                           
[31740] "Hemimelia"                                                                                                                                                            
[31741] "Hemoglobin_C_Disease"                                                                                                                                                 
[31742] "Hemoglobin_SC_Disease"                                                                                                                                                
[31743] "Hemoglobinuria"                                                                                                                                                       
[31744] "Hemoglobinuria_due_to_Hemolysis_from_External_Causes"                                                                                                                 
[31745] "Hemoperitoneum"                                                                                                                                                       
[31746] "Non-Traumatic_Hemoperitoneum"                                                                                                                                         
[31747] "Hemorrhage_of_Rectum_and_Anus"                                                                                                                                        
[31748] "Congo-Crimean_Hemorrhagic_Fever"                                                                                                                                      
[31749] "Dengue_Hemorrhagic_Fever"                                                                                                                                             
[31750] "Alcoholic_Hepatitis"                                                                                                                                                  
[31751] "Hernia"                                                                                                                                                               
[31752] "Hernia_without_mention_of_Obstruction_or_Gangrene"                                                                                                                    
[31753] "Diaphragmatic_Hernia"                                                                                                                                                 
[31754] "Traumatic_Diaphragmatic_Hernia"                                                                                                                                       
[31755] "Femoral_Hernia"                                                                                                                                                       
[31756] "Inguinal_Hernia"                                                                                                                                                      
[31757] "Direct_Inguinal_Hernia"                                                                                                                                               
[31758] "Indirect_Inguinal_Hernia"                                                                                                                                             
[31759] "Scrotal_Hernia"                                                                                                                                                       
[31760] "Heroin_Dependence"                                                                                                                                                    
[31761] "Cold_Sore"                                                                                                                                                            
[31762] "Herpes_Zoster_Dermatitis_of_Eyelid"                                                                                                                                   
[31763] "Herpetic_Vulvovaginitis"                                                                                                                                              
[31764] "Hip_Dislocation"                                                                                                                                                      
[31765] "Hip_Pain"                                                                                                                                                             
[31766] "Aganglionic_Megacolon"                                                                                                                                                
[31767] "Hookworm_Infection"                                                                                                                                                   
[31768] "Hyperalgesia"                                                                                                                                                         
[31769] "Type_II_Hyperlipidemia"                                                                                                                                               
[31770] "Hypergammaglobulinemia"                                                                                                                                               
[31771] "Hyperactivity"                                                                                                                                                        
[31772] "Hyperlipidemia"                                                                                                                                                       
[31773] "Type_IIb_Hyperlipoproteinemia"                                                                                                                                        
[31774] "Hyperlipoproteinemia"                                                                                                                                                 
[31775] "Remnant_Hyperlipidemia"                                                                                                                                               
[31776] "Fredrickson_Type_IV_Lipidemia"                                                                                                                                        
[31777] "Hyperostosis"                                                                                                                                                         
[31778] "Hyperostosis_of_Skull"                                                                                                                                                
[31779] "Hypersplenism"                                                                                                                                                        
[31780] "Hypertelorism"                                                                                                                                                        
[31781] "Hypertropia"                                                                                                                                                          
[31782] "Hypogalactia"                                                                                                                                                         
[31783] "Hypohidrosis"                                                                                                                                                         
[31784] "Hypomenorrhea"                                                                                                                                                        
[31785] "Hypotrichosis"                                                                                                                                                        
[31786] "Hysteria"                                                                                                                                                             
[31787] "Illusion"                                                                                                                                                             
[31788] "Impulse-Control_Disorder"                                                                                                                                             
[31789] "Low_Birth_Weight"                                                                                                                                                     
[31790] "Premature_Infant"                                                                                                                                                     
[31791] "Infectious_Mononucleosis"                                                                                                                                             
[31792] "Infective_Otitis_Externa"                                                                                                                                             
[31793] "Inguinal_Hernia_without_mention_of_Obstruction_or_Gangrene"                                                                                                           
[31794] "Injury_to_Diaphragm_without_mention_of_Open_Wound_into_Cavity"                                                                                                        
[31795] "Insulin_Coma"                                                                                                                                                         
[31796] "Intestinal_Disaccharidase_Deficiency_and_Disaccharidase_Malabsorption"                                                                                                
[31797] "Intestinal_Fistula"                                                                                                                                                   
[31798] "Intestinal_Pseudo-obstruction"                                                                                                                                        
[31799] "Intracranial_Abscess"                                                                                                                                                 
[31800] "Intraoperative_Complication"                                                                                                                                          
[31801] "Iridocyclitis"                                                                                                                                                        
[31802] "Iris_Disorder"                                                                                                                                                        
[31803] "Ischemia"                                                                                                                                                             
[31804] "Jacksonian_Seizure"                                                                                                                                                   
[31805] "Cholestatic_Jaundice"                                                                                                                                                 
[31806] "Dubin-Johnson_Syndrome"                                                                                                                                               
[31807] "Obstructive_Jaundice"                                                                                                                                                 
[31808] "Dendritic_Keratitis"                                                                                                                                                  
[31809] "Keratoconjunctivitis"                                                                                                                                                 
[31810] "Keratoderma"                                                                                                                                                          
[31811] "Acquired_Keratoderma"                                                                                                                                                 
[31812] "Keratosis"                                                                                                                                                            
[31813] "Palmoplantar_Keratoderma"                                                                                                                                             
[31814] "Acute_Renal_Failure_with_Tubular_Necrosis"                                                                                                                            
[31815] "Cystic_Kidney_Disease"                                                                                                                                                
[31816] "Medullary_Sponge_Kidney"                                                                                                                                              
[31817] "Klinefelter_s_Syndrome"                                                                                                                                               
[31818] "Knee_Injury"                                                                                                                                                          
[31819] "Kyphosis"                                                                                                                                                             
[31820] "Acquired_Kyphosis"                                                                                                                                                    
[31821] "Acquired_Postural_Kyphosis"                                                                                                                                           
[31822] "Lacrimal_Duct_Obstruction"                                                                                                                                            
[31823] "Visceral_Larva_Migrans"                                                                                                                                               
[31824] "Latent_Schizophrenia"                                                                                                                                                 
[31825] "Laurence-Moon_Syndrome"                                                                                                                                               
[31826] "Lead_Poisoning"                                                                                                                                                       
[31827] "Leg_Cramp"                                                                                                                                                            
[31828] "Leg_Injury"                                                                                                                                                           
[31829] "Leg_Pain"                                                                                                                                                             
[31830] "Lower_Extremity_Ulcer"                                                                                                                                                
[31831] "Perthes_Disease"                                                                                                                                                      
[31832] "Leishmaniasis"                                                                                                                                                        
[31833] "Cutaneous_Leishmaniasis"                                                                                                                                              
[31834] "American_Cutaneous_Leishmaniasis"                                                                                                                                     
[31835] "Asian_Desert_Cutaneous_Leishmaniasis"                                                                                                                                 
[31836] "Kala-Azar"                                                                                                                                                            
[31837] "Lens_Subluxation"                                                                                                                                                     
[31838] "Leriche_Syndrome"                                                                                                                                                     
[31839] "Chronic_Monocytic_Leukemia"                                                                                                                                           
[31840] "Leukorrhea"                                                                                                                                                           
[31841] "Lice"                                                                                                                                                                 
[31842] "Atrophic_Lichen_Planus"                                                                                                                                               
[31843] "Bullous_Lichen_Planus"                                                                                                                                                
[31844] "Hypertrophic_Lichen_Planus"                                                                                                                                           
[31845] "Lichenoid_Drug_Eruption"                                                                                                                                              
[31846] "Spastic_Diplegia"                                                                                                                                                     
[31847] "Alcoholic_Cirrhosis"                                                                                                                                                  
[31848] "Alcoholic_Liver_Disease"                                                                                                                                              
[31849] "Loiasis"                                                                                                                                                              
[31850] "Loneliness"                                                                                                                                                           
[31851] "Long_QT_Syndrome"                                                                                                                                                     
[31852] "Lordosis"                                                                                                                                                             
[31853] "Lower_Back_Pain"                                                                                                                                                      
[31854] "Lupus_Glomerulonephritis"                                                                                                                                             
[31855] "Lymphangitis"                                                                                                                                                         
[31856] "Lymphocytosis"                                                                                                                                                        
[31857] "Hemophagocytic_Lymphohistiocytosis"                                                                                                                                   
[31858] "Macular_Corneal_Dystrophy"                                                                                                                                            
[31859] "Cystoid_Macular_Edema"                                                                                                                                                
[31860] "Macular_Hole"                                                                                                                                                         
[31861] "Single_Episode_of_Major_Depressive_Disorder"                                                                                                                          
[31862] "Malaria"                                                                                                                                                              
[31863] "Falciparum_Malaria"                                                                                                                                                   
[31864] "Quartan_Malaria"                                                                                                                                                      
[31865] "Vivax_Malaria"                                                                                                                                                        
[31866] "Male_Erectile_Disorder"                                                                                                                                               
[31867] "Malignant_Essential_Hypertension"                                                                                                                                     
[31868] "Primary_Malignant_Neoplasm_of_Liver"                                                                                                                                  
[31869] "Malposition_of_Heart_and_Cardiac_Apex"                                                                                                                                
[31870] "Manic_Bipolar_Affective_Disorder"                                                                                                                                     
[31871] "Maple_Syrup_Urine_Disease"                                                                                                                                            
[31872] "Marfan_s_Syndrome"                                                                                                                                                    
[31873] "Mass"                                                                                                                                                                 
[31874] "Maxillary_Sinusitis"                                                                                                                                                  
[31875] "Megacolon"                                                                                                                                                            
[31876] "Megaesophagus"                                                                                                                                                        
[31877] "Melancholia"                                                                                                                                                          
[31878] "Meningoencephalitis"                                                                                                                                                  
[31879] "Menopausal_Syndrome"                                                                                                                                                  
[31880] "Menstrual_Disorder"                                                                                                                                                   
[31881] "Inborn_Errors_of_Metabolism"                                                                                                                                          
[31882] "Methemoglobinemia"                                                                                                                                                    
[31883] "Metrorrhagia"                                                                                                                                                         
[31884] "Mikulicz_Disease"                                                                                                                                                     
[31885] "Miliaria"                                                                                                                                                             
[31886] "Mixed_Hyperlipidemia"                                                                                                                                                 
[31887] "Closed_Monteggia_s_Fracture"                                                                                                                                          
[31888] "Mosquito-Born_Viral_Encephalitis"                                                                                                                                     
[31889] "Motion_Sickness"                                                                                                                                                      
[31890] "Kawasaki_Disease"                                                                                                                                                     
[31891] "Mucous_Polyp_of_Cervix"                                                                                                                                               
[31892] "Muscle_Cramp"                                                                                                                                                         
[31893] "Flaccidity"                                                                                                                                                           
[31894] "Myocardial_Degeneration"                                                                                                                                              
[31895] "Cardiomyopathy"                                                                                                                                                       
[31896] "Myocarditis"                                                                                                                                                          
[31897] "Myoclonic_Jerk"                                                                                                                                                       
[31898] "Myotonic_Cataract"                                                                                                                                                    
[31899] "Myxedema"                                                                                                                                                             
[31900] "Nabothian_Cyst"                                                                                                                                                       
[31901] "Ingrown_Toenail"                                                                                                                                                      
[31902] "Nasopharyngitis"                                                                                                                                                      
[31903] "Necatoriasis"                                                                                                                                                         
[31904] "Neck_Sprain"                                                                                                                                                          
[31905] "Necrobiosis_Lipoidica"                                                                                                                                                
[31906] "Avascular_Necrosis_of_Bone"                                                                                                                                           
[31907] "Alport_s_Syndrome"                                                                                                                                                    
[31908] "Nephropathy"                                                                                                                                                          
[31909] "Minimal_Change_Glomerulonephritis"                                                                                                                                    
[31910] "Nephrotic_Syndrome"                                                                                                                                                   
[31911] "Nervous_Debility"                                                                                                                                                     
[31912] "Neuronitis"                                                                                                                                                           
[31913] "Neurosis"                                                                                                                                                             
[31914] "Newcastle_Disease"                                                                                                                                                    
[31915] "Night_Blindness"                                                                                                                                                      
[31916] "Increased_NPN"                                                                                                                                                        
[31917] "Gangrenous_Stomatitis"                                                                                                                                                
[31918] "Non-Autoimmune_Hemolytic_Anemia"                                                                                                                                      
[31919] "Noonan_Syndrome"                                                                                                                                                      
[31920] "Norwegian_Scabies"                                                                                                                                                    
[31921] "Acquired_Deformity_of_Nose"                                                                                                                                           
[31922] "Numbness"                                                                                                                                                             
[31923] "Morbid_Obesity"                                                                                                                                                       
[31924] "Occupational_Dermatitis"                                                                                                                                              
[31925] "Oligospermia"                                                                                                                                                         
[31926] "Onchocerciasis"                                                                                                                                                       
[31927] "Ocular_Onchocerciasis"                                                                                                                                                
[31928] "Optic_Atrophy"                                                                                                                                                        
[31929] "Hereditary_Optic_Atrophy"                                                                                                                                             
[31930] "Optical_Illusion"                                                                                                                                                     
[31931] "Oral_Cavity_Submucous_Fibrosis"                                                                                                                                       
[31932] "Organic_Anxiety_Disorder"                                                                                                                                             
[31933] "Organic_Brain_Syndrome"                                                                                                                                               
[31934] "Organic_Delusional_Syndrome"                                                                                                                                          
[31935] "Organic_Mental_Disorder"                                                                                                                                              
[31936] "Organic_Affective_Syndrome"                                                                                                                                           
[31937] "Organic_Personality_Syndrome"                                                                                                                                         
[31938] "Ornithosis"                                                                                                                                                           
[31939] "Osgood-Schlatter_s_Disease"                                                                                                                                           
[31940] "Osteitis_Fibrosa_Cystica"                                                                                                                                             
[31941] "Hip_Osteoarthritis"                                                                                                                                                   
[31942] "Osteochondritis"                                                                                                                                                      
[31943] "Osteochondritis_Dissecans"                                                                                                                                            
[31944] "Osteochondrosis"                                                                                                                                                      
[31945] "Bone_Necrosis"                                                                                                                                                        
[31946] "Congenital_Deformity_of_Hip"                                                                                                                                          
[31947] "Rheumatic_Heart_Disease"                                                                                                                                              
[31948] "Multiple_Dislocations"                                                                                                                                                
[31949] "Otitis"                                                                                                                                                               
[31950] "Otitis_Media"                                                                                                                                                         
[31951] "Secretory_Otitis_Media"                                                                                                                                               
[31952] "Post-operative_Pain"                                                                                                                                                  
[31953] "Palmoplantar_Pustulosis"                                                                                                                                              
[31954] "Pancytopenia"                                                                                                                                                         
[31955] "Panic_Disorder"                                                                                                                                                       
[31956] "Paracoccidioidomycosis"                                                                                                                                               
[31957] "Parakeratosis"                                                                                                                                                        
[31958] "Paraphimosis"                                                                                                                                                         
[31959] "Paratyphoid_Fever_A"                                                                                                                                                  
[31960] "Paratyphoid_Fever_B"                                                                                                                                                  
[31961] "Paratyphoid_Fever_C"                                                                                                                                                  
[31962] "Paratyphoid_Fever"                                                                                                                                                    
[31963] "Postencephalitic_Parkinsonism"                                                                                                                                        
[31964] "Secondary_Parkinsonism"                                                                                                                                               
[31965] "Paroxysmal_Atrial_Tachycardia"                                                                                                                                        
[31966] "Paroxysmal_Supraventricular_Tachycardia"                                                                                                                              
[31967] "Paroxysmal_Ventricular_Tachycardia"                                                                                                                                   
[31968] "Pars_Planitis"                                                                                                                                                        
[31969] "Passive-Aggressive_Personality"                                                                                                                                       
[31970] "Head_Lice"                                                                                                                                                            
[31971] "Body_Lice"                                                                                                                                                            
[31972] "Benign_Mucous_Membrane_Pemphigoid"                                                                                                                                    
[31973] "Pemphigoid"                                                                                                                                                           
[31974] "Pemphigus"                                                                                                                                                            
[31975] "Pemphigus_Vulgaris"                                                                                                                                                   
[31976] "Penicillin_Allergy"                                                                                                                                                   
[31977] "Perceptual_Distortion"                                                                                                                                                
[31978] "Dentoalveolar_Abscess"                                                                                                                                                
[31979] "Periapical_Abscess_with_Sinus"                                                                                                                                        
[31980] "Pericarditis"                                                                                                                                                         
[31981] "Pericholangitis"                                                                                                                                                      
[31982] "Periodontal_Abscess"                                                                                                                                                  
[31983] "Periodontitis"                                                                                                                                                        
[31984] "Peripheral_Retinal_Degeneration"                                                                                                                                      
[31985] "Chronic_Peritoneal_Effusion"                                                                                                                                          
[31986] "Ostium_Primum_Defect"                                                                                                                                                 
[31987] "Personality_Disorder"                                                                                                                                                 
[31988] "Stump_Hallucination"                                                                                                                                                  
[31989] "Pharyngoconjunctival_Fever"                                                                                                                                           
[31990] "Phlegmon"                                                                                                                                                             
[31991] "School_Phobia"                                                                                                                                                        
[31992] "Social_Phobia"                                                                                                                                                        
[31993] "Phocomelia"                                                                                                                                                           
[31994] "Photodermatitis"                                                                                                                                                      
[31995] "Abnormal_Pigmentation"                                                                                                                                                
[31996] "Pilonidal_Cyst"                                                                                                                                                       
[31997] "Aspiration_Pneumonia"                                                                                                                                                 
[31998] "Poisoning"                                                                                                                                                            
[31999] "Polyradiculopathy"                                                                                                                                                    
[32000] "Baker_s_Cyst"                                                                                                                                                         
[32001] "Post_Kala-Azar_Dermal_Leishmaniasis"                                                                                                                                  
[32002] "Postmenopausal_Hemorrhage"                                                                                                                                            
[32003] "Postoperative_Bleeding"                                                                                                                                               
[32004] "Potassium_Deficiency"                                                                                                                                                 
[32005] "Pre-Excitation_Syndrome"                                                                                                                                              
[32006] "Pregnancy_Complication"                                                                                                                                               
[32007] "Diabetes_in_Pregnancy"                                                                                                                                                
[32008] "Toxemia_of_Pregnancy"                                                                                                                                                 
[32009] "Abdominal_Pregnancy"                                                                                                                                                  
[32010] "Ectopic_Pregnancy"                                                                                                                                                    
[32011] "Ovarian_Pregnancy"                                                                                                                                                    
[32012] "Tubal_Pregnancy"                                                                                                                                                      
[32013] "Puncture_Wound"                                                                                                                                                       
[32014] "Primary_Insomnia"                                                                                                                                                     
[32015] "Proctosigmoiditis"                                                                                                                                                    
[32016] "Progeria"                                                                                                                                                             
[32017] "Protein_Energy_Malnutrition"                                                                                                                                          
[32018] "Protozoal_Infection"                                                                                                                                                  
[32019] "Pruritus_Vulvae"                                                                                                                                                      
[32020] "Pseudogout"                                                                                                                                                           
[32021] "Psychosomatic_Disorder"                                                                                                                                               
[32022] "Drug-Induced_Psychosis"                                                                                                                                               
[32023] "Female_Orgasmic_Disorder"                                                                                                                                             
[32024] "Male_Orgasmic_Disorder"                                                                                                                                               
[32025] "Psychosexual_Dysfunction_with_Inhibited_Sexual_Excitement"                                                                                                            
[32026] "Congenital_Infundibular_Stenosis"                                                                                                                                     
[32027] "Pulp_Degeneration"                                                                                                                                                    
[32028] "Henoch-Schonlein_Purpura"                                                                                                                                             
[32029] "Pyelitis"                                                                                                                                                             
[32030] "Pyelonephritis"                                                                                                                                                       
[32031] "Pyloric_Stenosis"                                                                                                                                                     
[32032] "Lobular_Capillary_Hemangioma_of_Skin_and_Subcutaneous_Tissue"                                                                                                         
[32033] "Pyosalpinx"                                                                                                                                                           
[32034] "Pyridoxine_Deficiency"                                                                                                                                                
[32035] "Q_Fever"                                                                                                                                                              
[32036] "Rat-Bite_Fever"                                                                                                                                                       
[32037] "Raynaud_s_Disease"                                                                                                                                                    
[32038] "Rectal_Prolapse"                                                                                                                                                      
[32039] "Pure_Red_Cell_Aplasia"                                                                                                                                                
[32040] "Reiter_s_Syndrome"                                                                                                                                                    
[32041] "Tick-Born_Relapsing_Fever"                                                                                                                                            
[32042] "Reticuloendothelial_Hyperplasia"                                                                                                                                      
[32043] "Retinal_Artery_Occlusion"                                                                                                                                             
[32044] "Retinal_Degeneration"                                                                                                                                                 
[32045] "Retinal_Vascular_Occlusion"                                                                                                                                           
[32046] "Retinal_Vein_Occlusion"                                                                                                                                               
[32047] "Retrolental_Fibroplasia"                                                                                                                                              
[32048] "Reye_s_Syndrome"                                                                                                                                                      
[32049] "Rheumatic_Fever"                                                                                                                                                      
[32050] "Acute_Rheumatic_Heart_Disease"                                                                                                                                        
[32051] "Rhinitis"                                                                                                                                                             
[32052] "Atopic_Rhinitis"                                                                                                                                                      
[32053] "Vasomotor_Rhinitis"                                                                                                                                                   
[32054] "Rhinophyma"                                                                                                                                                           
[32055] "Rib_Fracture"                                                                                                                                                         
[32056] "Rickettsiosis"                                                                                                                                                        
[32057] "Congenital_Rubella"                                                                                                                                                   
[32058] "Salivary_Duct_Stone"                                                                                                                                                  
[32059] "Salivary_Gland_Stone"                                                                                                                                                 
[32060] "Sarcoidosis"                                                                                                                                                          
[32061] "Cutaneous_Sarcoidosis"                                                                                                                                                
[32062] "Pulmonary_Sarcoidosis"                                                                                                                                                
[32063] "Scabies"                                                                                                                                                              
[32064] "Juvenile_Osteochondrosis_of_Spine"                                                                                                                                    
[32065] "Schistosomiasis"                                                                                                                                                      
[32066] "Schistosoma_Japonicum_Infection"                                                                                                                                      
[32067] "Schistosoma_Mansoni_Infection"                                                                                                                                        
[32068] "Catatonic_Type_Schizophrenia"                                                                                                                                         
[32069] "Childhood_Schizophrenia"                                                                                                                                              
[32070] "Disorganized_Type_Schizophrenia"                                                                                                                                      
[32071] "Paranoid_Type_Schizophrenia"                                                                                                                                          
[32072] "Residual_Type_Schizophrenia"                                                                                                                                          
[32073] "Schwartz_Syndrome"                                                                                                                                                    
[32074] "Sclerema_Neonatorum"                                                                                                                                                  
[32075] "Scurvy"                                                                                                                                                               
[32076] "Sea_Sickness"                                                                                                                                                         
[32077] "Senile_Cataract"                                                                                                                                                      
[32078] "Senile_Corneal_Change"                                                                                                                                                
[32079] "Separation_Anxiety_Disorder"                                                                                                                                          
[32080] "Shivering"                                                                                                                                                            
[32081] "Shock"                                                                                                                                                                
[32082] "Hemorrhagic_Shock"                                                                                                                                                    
[32083] "Septic_Shock"                                                                                                                                                         
[32084] "Surgical_Shock"                                                                                                                                                       
[32085] "Shoulder_Dislocation"                                                                                                                                                 
[32086] "Shoulder_Fracture"                                                                                                                                                    
[32087] "Shoulder_Pain"                                                                                                                                                        
[32088] "Endemic_Goiter"                                                                                                                                                       
[32089] "Sinusitis"                                                                                                                                                            
[32090] "Skin_Infection"                                                                                                                                                       
[32091] "Skin_Pigmentation"                                                                                                                                                    
[32092] "Smallpox"                                                                                                                                                             
[32093] "Modified_Smallpox"                                                                                                                                                    
[32094] "Socialized_Conduct_Disorder"                                                                                                                                          
[32095] "Sparganosis"                                                                                                                                                          
[32096] "Sphenoidal_Sinusitis"                                                                                                                                                 
[32097] "Splenic_Rupture"                                                                                                                                                      
[32098] "Spondylolisthesis"                                                                                                                                                    
[32099] "Spondylolysis"                                                                                                                                                        
[32100] "Sprain"                                                                                                                                                               
[32101] "Staphylococcus_Aureus_Gastroenteritis"                                                                                                                                
[32102] "Staphylococcal_Food_Poisoning"                                                                                                                                        
[32103] "Staphylococcal_Infection"                                                                                                                                             
[32104] "Ulcerative_Stomatitis"                                                                                                                                                
[32105] "Strabismus"                                                                                                                                                           
[32106] "Stress"                                                                                                                                                               
[32107] "Female_Stress_Incontinence"                                                                                                                                           
[32108] "Stutter"                                                                                                                                                              
[32109] "Subclavian_Steal_Syndrome"                                                                                                                                            
[32110] "Subconjunctival_Hemorrhage"                                                                                                                                           
[32111] "Withdrawal_Syndrome"                                                                                                                                                  
[32112] "Sun_Stroke"                                                                                                                                                           
[32113] "Superficial_Injury_of_Cornea"                                                                                                                                         
[32114] "Wound_Breakdown"                                                                                                                                                      
[32115] "Surgical_Wound_Infection"                                                                                                                                             
[32116] "Diaphoresis"                                                                                                                                                          
[32117] "Sweating_Fever"                                                                                                                                                       
[32118] "Syncope"                                                                                                                                                              
[32119] "Syphilis"                                                                                                                                                             
[32120] "Latent_Syphilis"                                                                                                                                                      
[32121] "Tabes_Dorsalis"                                                                                                                                                       
[32122] "Atrioventricular_Nodal_Reentry_Tachycardia"                                                                                                                           
[32123] "Junctional_Tachycardia"                                                                                                                                               
[32124] "Paroxysmal_Tachycardia"                                                                                                                                               
[32125] "Supraventricular_Tachycardia"                                                                                                                                         
[32126] "Takayasu_s_Arteritis"                                                                                                                                                 
[32127] "Teething_Syndrome"                                                                                                                                                    
[32128] "Hereditary_Hemorrhagic_Telangiectasia"                                                                                                                                
[32129] "Temporal_Arteritis"                                                                                                                                                   
[32130] "Temporomandibular_Joint_Dysfunction_Syndrome"                                                                                                                         
[32131] "Lateral_Epicondylitis"                                                                                                                                                
[32132] "Tetanic_Cataract"                                                                                                                                                     
[32133] "Thalassemia"                                                                                                                                                          
[32134] "Buerger_s_Disease"                                                                                                                                                    
[32135] "Subacute_Thyroiditis"                                                                                                                                                 
[32136] "Favus"                                                                                                                                                                
[32137] "Deep_Seated_Dermatophytosis"                                                                                                                                          
[32138] "Tobacco_Use_Disorder"                                                                                                                                                 
[32139] "Hairy_Tongue"                                                                                                                                                         
[32140] "Tooth_Abrasion"                                                                                                                                                       
[32141] "Dental_Disorder"                                                                                                                                                      
[32142] "Tourette_s_Syndrome"                                                                                                                                                  
[32143] "Tracheal_Disorder"                                                                                                                                                    
[32144] "Tracheoesophageal_Fistula"                                                                                                                                            
[32145] "Traumatic_Myositis_Ossificans"                                                                                                                                        
[32146] "Traumatic_Subcutaneous_Emphysema"                                                                                                                                     
[32147] "Trichomonas_Vaginitis"                                                                                                                                                
[32148] "Gambian_Trypanosomiasis"                                                                                                                                              
[32149] "Rhodesian_Trypanosomiasis"                                                                                                                                            
[32150] "Miliary_Tuberculosis"                                                                                                                                                 
[32151] "Pott_s_Disease"                                                                                                                                                       
[32152] "Tuberculous_Fibrosis_of_Lung"                                                                                                                                         
[32153] "Typhoid_Fever"                                                                                                                                                        
[32154] "Umbilical_Hernia_without_mention_of_Obstruction_or_Gangrene"                                                                                                          
[32155] "Undersocialized_Conduct_Disorder_Aggressive_Type"                                                                                                                     
[32156] "Attention_Deficit_Disorder"                                                                                                                                           
[32157] "Solitary_Bone_Cyst"                                                                                                                                                   
[32158] "Unipolar_Depression"                                                                                                                                                  
[32159] "Perinatal_Disorder"                                                                                                                                                   
[32160] "Deformity_of_Forearm"                                                                                                                                                 
[32161] "Idiopathic_Neuropathy"                                                                                                                                                
[32162] "Local_Infection_of_Skin_and_Subcutaneous_Tissue"                                                                                                                      
[32163] "Nonpsychotic_Mental_Disorder_Following_Organic_Brain_Damage"                                                                                                          
[32164] "Pruritic_Disorder"                                                                                                                                                    
[32165] "Transient_Organic_Mental_Disorder"                                                                                                                                    
[32166] "Uremia"                                                                                                                                                               
[32167] "Increased_Uric_Acid_Level"                                                                                                                                            
[32168] "Female_Genitourinary_Fistula"                                                                                                                                         
[32169] "Congenital_Genitourinary_Abnormality"                                                                                                                                 
[32170] "Uterine_Prolapse"                                                                                                                                                     
[32171] "Anterior_Uveitis"                                                                                                                                                     
[32172] "Intermediate_Uveitis"                                                                                                                                                 
[32173] "Posterior_Uveitis"                                                                                                                                                    
[32174] "Vaginal_Itching"                                                                                                                                                      
[32175] "Psychogenic_Vaginismus"                                                                                                                                               
[32176] "Varicose_Vein"                                                                                                                                                        
[32177] "Varicose_Vein_of_Lower_Extremities_with_Inflammation"                                                                                                                 
[32178] "Conjunctival_Vascular_Disorder"                                                                                                                                       
[32179] "Vascular_Disorder"                                                                                                                                                    
[32180] "Vascular_Headache"                                                                                                                                                    
[32181] "Allergic_Cutaneous_Angiitis"                                                                                                                                          
[32182] "Vasovagal_Syncope"                                                                                                                                                    
[32183] "Venezuelan_Equine_Fever"                                                                                                                                              
[32184] "Ventral_Hernia_without_mention_of_Obstruction_or_Gangrene"                                                                                                            
[32185] "Vertebral_Artery_Syndrome"                                                                                                                                            
[32186] "Viral_Hepatitis"                                                                                                                                                      
[32187] "Viremia"                                                                                                                                                              
[32188] "Vision_Disorder"                                                                                                                                                      
[32189] "Partial_Sight"                                                                                                                                                        
[32190] "Visual_Discomfort"                                                                                                                                                    
[32191] "Vitamin_B_Deficiency"                                                                                                                                                 
[32192] "Volkmann_s_Ischemic_Contracture"                                                                                                                                      
[32193] "Vulvovaginitis"                                                                                                                                                       
[32194] "Wolff-Parkinson-White_Syndrome"                                                                                                                                       
[32195] "Wolfram_Syndrome"                                                                                                                                                     
[32196] "Xeroderma"                                                                                                                                                            
[32197] "Operative_Hemorrhage"                                                                                                                                                 
[32198] "Peripheral_Vascular_Disorder"                                                                                                                                         
[32199] "Ankle_Injury"                                                                                                                                                         
[32200] "Pharyngoesophageal_Diverticulum"                                                                                                                                      
[32201] "Alagille_Syndrome"                                                                                                                                                    
[32202] "Dental_Phobia"                                                                                                                                                        
[32203] "Microcytic_Anemia"                                                                                                                                                    
[32204] "Normocytic_Anemia"                                                                                                                                                    
[32205] "Chills"                                                                                                                                                               
[32206] "Vasospasm"                                                                                                                                                            
[32207] "Acute_Appendicitis"                                                                                                                                                   
[32208] "Chronic_Cholecystitis"                                                                                                                                                
[32209] "Monocytosis"                                                                                                                                                          
[32210] "Mycotic_Aneurysm"                                                                                                                                                     
[32211] "Bullous_Dermatitis"                                                                                                                                                   
[32212] "Eosinophilic_Pneumonia"                                                                                                                                               
[32213] "Chronic_Sinusitis"                                                                                                                                                    
[32214] "Acute_Cholecystitis"                                                                                                                                                  
[32215] "Fracture_of_Pelvis"                                                                                                                                                   
[32216] "Foreign_Body_in_Esophagus"                                                                                                                                            
[32217] "Adnexal_Mass"                                                                                                                                                         
[32218] "Elbow_Injury"                                                                                                                                                         
[32219] "Foot_Injury"                                                                                                                                                          
[32220] "Lower_Respiratory_Tract_Infection"                                                                                                                                    
[32221] "Pulmonary_Mass"                                                                                                                                                       
[32222] "Neck_Mass"                                                                                                                                                            
[32223] "Nipple_Discharge"                                                                                                                                                     
[32224] "Campylobacter_Gastroenteritis"                                                                                                                                        
[32225] "Skin_Atrophy"                                                                                                                                                         
[32226] "Neutrophilia"                                                                                                                                                         
[32227] "Accidental_Injury"                                                                                                                                                    
[32228] "Manic_Psychosis"                                                                                                                                                      
[32229] "Hypocellular_Bone_Marrow"                                                                                                                                             
[32230] "Megakaryocytes_Increased"                                                                                                                                             
[32231] "Pregnancy_Disorder"                                                                                                                                                   
[32232] "Retinal_Vascular_Disorder"                                                                                                                                            
[32233] "Toxic_Nodular_Goiter"                                                                                                                                                 
[32234] "Congenital_Aphakia"                                                                                                                                                   
[32235] "Chronic_Glomerulonephritis"                                                                                                                                           
[32236] "Mosquito-Born_Hemorrhagic_Fever"                                                                                                                                      
[32237] "Ancylostomiasis_due_to_Ancylostoma_Braziliense"                                                                                                                       
[32238] "Trichomonas_Prostatitis"                                                                                                                                              
[32239] "Malignant_Uvula_Neoplasm"                                                                                                                                             
[32240] "Malignant_Neoplasm_of_Lower_Jaw_Bone"                                                                                                                                 
[32241] "Gastrointestinal_Carcinoma_in_situ"                                                                                                                                   
[32242] "Latent_Subchronic_Schizophrenia"                                                                                                                                      
[32243] "Latent_Chronic_Schizophrenia"                                                                                                                                         
[32244] "Residual_Subchronic_Schizophrenia"                                                                                                                                    
[32245] "Residual_Chronic_Schizophrenia"                                                                                                                                       
[32246] "Subchronic_Schizophrenia"                                                                                                                                             
[32247] "Physiological_Malfunction_Arising_from_Mental_Factor"                                                                                                                 
[32248] "Musculoskeletal_Malfunction_Arising_from_Mental_Factor"                                                                                                               
[32249] "Skin_Disorder_Arising_from_Mental_Factor"                                                                                                                             
[32250] "Genitourinary_Malfunction_Arising_from_Mental_Factor"                                                                                                                 
[32251] "Endocrine_Disorder_Arising_from_Mental_Factor"                                                                                                                        
[32252] "Adjustment_Reaction_with_Prolonged_Depressive_Reaction"                                                                                                               
[32253] "Partial_Retinal_Arterial_Occlusion"                                                                                                                                   
[32254] "Transient_Retinal_Arterial_Occlusion"                                                                                                                                 
[32255] "Hereditary_Retinal_Dystrophy"                                                                                                                                         
[32256] "Acute_Conjunctivitis"                                                                                                                                                 
[32257] "Pseudomembranous_Conjunctivitis"                                                                                                                                      
[32258] "Chronic_Conjunctivitis"                                                                                                                                               
[32259] "Eyelid_Vascular_Disorder"                                                                                                                                             
[32260] "Otorrhea"                                                                                                                                                             
[32261] "Acute_Rheumatic_Pericarditis"                                                                                                                                         
[32262] "Acute_Rheumatic_Endocarditis"                                                                                                                                         
[32263] "Acute_Rheumatic_Myocarditis"                                                                                                                                          
[32264] "Unspecified_Renovascular_Hypertension"                                                                                                                                
[32265] "Acute_Myocardial_Infarction"                                                                                                                                          
[32266] "Old_Myocardial_Infarction"                                                                                                                                            
[32267] "Acute_Myocarditis"                                                                                                                                                    
[32268] "Non-Traumatic_Extradural_Hemorrhage"                                                                                                                                  
[32269] "Varicose_Vein_of_Lower_Extremities"                                                                                                                                   
[32270] "Femoral_Hernia_with_Obstruction"                                                                                                                                      
[32271] "Crohn_s_Disease_of_Small_Intestine"                                                                                                                                   
[32272] "Crohn_s_Colitis"                                                                                                                                                      
[32273] "Ischemic_Bowel_Disease"                                                                                                                                               
[32274] "Acute_Glomerulonephritis"                                                                                                                                             
[32275] "Nephrotic_Syndrome_with_Lesion_of_Proliferative_Glomerulonephritis"                                                                                                   
[32276] "Nephrotic_Syndrome_with_Lesion_of_Membranous_Glomerulonephritis"                                                                                                      
[32277] "Nephrotic_Syndrome_with_Lesion_of_Membranoproliferative_Glomerulonephritis"                                                                                           
[32278] "Chronic_Glomerulonephritis_with_Lesion_of_Proliferative_Glomerulonephritis"                                                                                           
[32279] "Penile_Vascular_Disorder"                                                                                                                                             
[32280] "Irregular_Menstruation"                                                                                                                                               
[32281] "Postcoital_Bleeding"                                                                                                                                                  
[32282] "Abortion"                                                                                                                                                             
[32283] "Unspecified_Antepartum_Hypertension"                                                                                                                                  
[32284] "Unspecified_Postpartum_Hypertension"                                                                                                                                  
[32285] "Dermatitis_due_to_Unspecified_Substance_taken_Internally"                                                                                                             
[32286] "Arthropathy_in_Behcet_s_Syndrome"                                                                                                                                     
[32287] "Aseptic_Necrosis_of_Head_of_Humerus"                                                                                                                                  
[32288] "Acquired_Hallux_Valgus"                                                                                                                                               
[32289] "Congenital_Anemia"                                                                                                                                                    
[32290] "Closed_Fracture_of_Mandible_Multiple_Sites"                                                                                                                           
[32291] "Closed_Fracture_of_Ribs_Multiple_Sites"                                                                                                                               
[32292] "Open_Fracture_of_Carpal_Bone"                                                                                                                                         
[32293] "Closed_Fracture_of_Metacarpal_Bone"                                                                                                                                   
[32294] "Open_Fracture_of_Metacarpal_Bone"                                                                                                                                     
[32295] "Injury_to_Diaphragm_with_Open_Wound_into_Cavity"                                                                                                                      
[32296] "Injury_to_Esophagus_without_mention_of_Open_Wound_into_Cavity"                                                                                                        
[32297] "Injury_to_Esophagus_with_Open_Wound_into_Cavity"                                                                                                                      
[32298] "Gastrointestinal_Injury"                                                                                                                                              
[32299] "Injury_to_Stomach_with_Open_Wound_into_Cavity"                                                                                                                        
[32300] "Injury_to_Duodenum_with_Open_Wound_into_Cavity"                                                                                                                       
[32301] "Injury_to_Rectum_with_Open_Wound_into_Cavity"                                                                                                                         
[32302] "Injury_to_Liver"                                                                                                                                                      
[32303] "Injury_to_Liver_without_mention_of_Open_Wound_into_Cavity"                                                                                                            
[32304] "Injury_to_Liver_with_Open_Wound_into_Cavity"                                                                                                                          
[32305] "Injury_to_Spleen_with_Open_Wound_into_Cavity"                                                                                                                         
[32306] "Injury_to_Kidney"                                                                                                                                                     
[32307] "Injury_to_Kidney_without_mention_of_Open_Wound_into_Cavity"                                                                                                           
[32308] "Injury_to_Kidney_with_Open_Wound_into_Cavity"                                                                                                                         
[32309] "Injury_to_Peritoneum_without_mention_of_Open_Wound_into_Cavity"                                                                                                       
[32310] "Injury_to_Peritoneum_with_Open_Wound_into_Cavity"                                                                                                                     
[32311] "Injury_to_Retroperitoneum_with_Open_Wound_into_Cavity"                                                                                                                
[32312] "Foreign_Body_in_Stomach"                                                                                                                                              
[32313] "Foreign_Body_in_Genitourinary_Tract"                                                                                                                                  
[32314] "Foreign_Body_in_Penis"                                                                                                                                                
[32315] "Skin_Vascular_Disorder"                                                                                                                                               
[32316] "Greig_s_Syndrome"                                                                                                                                                     
[32317] "Aicardi_Syndrome"                                                                                                                                                     
[32318] "Alper_s_Syndrome"                                                                                                                                                     
[32319] "Chondromatosis"                                                                                                                                                       
[32320] "Congenital_Adrenal_Hypoplasia"                                                                                                                                        
[32321] "Hereditary_Sideroblastic_Anemia"                                                                                                                                      
[32322] "Stress_Ulcer"                                                                                                                                                         
[32323] "Rapidly_Progressive_Glomerulonephritis"                                                                                                                               
[32324] "Acanthosis"                                                                                                                                                           
[32325] "Anisocytosis"                                                                                                                                                         
[32326] "Poikilocytosis"                                                                                                                                                       
[32327] "Macrocephaly"                                                                                                                                                         
[32328] "Simple_Type_Schizophrenia"                                                                                                                                            
[32329] "Chronic_Schizophrenia"                                                                                                                                                
[32330] "Nontoxic_Goiter"                                                                                                                                                      
[32331] "Lower_Abdominal_Pain"                                                                                                                                                 
[32332] "Animal_Phobia"                                                                                                                                                        
[32333] "Perception_Disturbance"                                                                                                                                               
[32334] "Visual_Cortex_Disorder"                                                                                                                                               
[32335] "Visual_Agnosia"                                                                                                                                                       
[32336] "Acneiform_Dermatitis"                                                                                                                                                 
[32337] "Chemically_Induced_Neurotoxicity"                                                                                                                                     
[32338] "Vein_Disorder"                                                                                                                                                        
[32339] "Focal_Glomerulonephritis"                                                                                                                                             
[32340] "Proliferative_Glomerulonephritis"                                                                                                                                     
[32341] "Alpha_Fetoprotein_Increased"                                                                                                                                          
[32342] "Specific_Phobia"                                                                                                                                                      
[32343] "Foreign_Body_in_Bladder"                                                                                                                                              
[32344] "C_Difficile_Colitis"                                                                                                                                                  
[32345] "Hemoglobin_E_Disease"                                                                                                                                                 
[32346] "Desquamative_Interstitial_Pneumonia"                                                                                                                                  
[32347] "Axillary_Mass"                                                                                                                                                        
[32348] "Mass_of_the_Back"                                                                                                                                                     
[32349] "Buttock_Mass"                                                                                                                                                         
[32350] "Low-Grade_Fever"                                                                                                                                                      
[32351] "Inguinal_Mass"                                                                                                                                                        
[32352] "Hepatic_Mass"                                                                                                                                                         
[32353] "Mediastinal_Mass"                                                                                                                                                     
[32354] "Nose_Deformity"                                                                                                                                                       
[32355] "Skin_Burning_Sensation"                                                                                                                                               
[32356] "Inferior_Vena_Cava_Occlusion"                                                                                                                                         
[32357] "Hemolytic_Jaundice"                                                                                                                                                   
[32358] "Sheehan_s_Syndrome"                                                                                                                                                   
[32359] "Loffler_s_Syndrome"                                                                                                                                                   
[32360] "Viral_Encephalitis"                                                                                                                                                   
[32361] "Anterolateral_Myocardial_Infarction"                                                                                                                                  
[32362] "Anteroseptal_Myocardial_Infarction"                                                                                                                                   
[32363] "Subendocardial_Myocardial_Infarction"                                                                                                                                 
[32364] "Renal_Mass"                                                                                                                                                           
[32365] "Axillary_Abscess"                                                                                                                                                     
[32366] "Allergic_Dermatitis_due_to_Arnica"                                                                                                                                    
[32367] "Dermatitis_due_to_Acids"                                                                                                                                              
[32368] "Dermatitis_due_to_Alkalis"                                                                                                                                            
[32369] "Dermatitis_due_to_Dichromate"                                                                                                                                         
[32370] "Sun_Exposure_Dermatitis"                                                                                                                                              
[32371] "Juvenile_Osteochondrosis"                                                                                                                                             
[32372] "Tracheal_Calcification"                                                                                                                                               
[32373] "Kaolin_Pneumoconiosis"                                                                                                                                                
[32374] "Chemical_Pneumonitis"                                                                                                                                                 
[32375] "Arterial_Disorder"                                                                                                                                                    
[32376] "Arterial_Occlusion"                                                                                                                                                   
[32377] "Internal_Hemorrhoid"                                                                                                                                                  
[32378] "External_Hemorrhoid"                                                                                                                                                  
[32379] "Coffin-Siris_Syndrome"                                                                                                                                                
[32380] "Phocomelia_of_the_Upper_Limb"                                                                                                                                         
[32381] "Phocomelia_of_the_Lower_Limb"                                                                                                                                         
[32382] "Congenital_Hallux_Valgus"                                                                                                                                             
[32383] "Congenital_Kyphosis"                                                                                                                                                  
[32384] "Chronic_Periodontitis"                                                                                                                                                
[32385] "Broncho-Esophageal_Fistula"                                                                                                                                           
[32386] "Injury_to_Esophagus"                                                                                                                                                  
[32387] "Crohn_s_Ileitis"                                                                                                                                                      
[32388] "Eosinophilic_Gastroenteritis"                                                                                                                                         
[32389] "Acute_Hepatitis"                                                                                                                                                      
[32390] "Cholecystitis_with_Cholelithiasis"                                                                                                                                    
[32391] "Cystic_Duct_Stone"                                                                                                                                                    
[32392] "Acute_Cholangitis"                                                                                                                                                    
[32393] "Chronic_Cholangitis"                                                                                                                                                  
[32394] "Suppurative_Cholangitis"                                                                                                                                              
[32395] "Congenital_Nephrotic_Syndrome"                                                                                                                                        
[32396] "Renal_Vascular_Disorder"                                                                                                                                              
[32397] "First_Degree_Uterine_Prolapse"                                                                                                                                        
[32398] "Second_Degree_Uterine_Prolapse"                                                                                                                                       
[32399] "Partial_Retinal_Vein_Occlusion"                                                                                                                                       
[32400] "Visual_Pathway_Disorder"                                                                                                                                              
[32401] "Drug-Induced_Aplastic_Anemia"                                                                                                                                         
[32402] "Hemoglobin_D_Disease"                                                                                                                                                 
[32403] "Acquired_Factor_VIII_Deficiency"                                                                                                                                      
[32404] "Lymph_Node_Disorder"                                                                                                                                                  
[32405] "Splenic_Abscess"                                                                                                                                                      
[32406] "Ear_Injury"                                                                                                                                                           
[32407] "Nose_Injury"                                                                                                                                                          
[32408] "Closed_Fracture_of_Rib"                                                                                                                                               
[32409] "Open_Fracture_of_Rib"                                                                                                                                                 
[32410] "Closed_Fracture_of_Pelvis"                                                                                                                                            
[32411] "Open_Fracture_of_Pelvis"                                                                                                                                              
[32412] "Fracture_of_Metacarpal_Bone"                                                                                                                                          
[32413] "Closed_Fracture_of_Shaft_of_Metacarpal_Bone"                                                                                                                          
[32414] "Closed_Fracture_of_Neck_of_Metacarpal_Bone"                                                                                                                           
[32415] "Open_Fracture_of_Shaft_of_Metacarpal_Bone"                                                                                                                            
[32416] "Open_Fracture_of_Neck_of_Metacarpal_Bone"                                                                                                                             
[32417] "Burn_of_Axilla"                                                                                                                                                       
[32418] "Cytomegaloviral_Pneumonia"                                                                                                                                            
[32419] "Cryptococcal_Pneumonia"                                                                                                                                               
[32420] "Bladder_Schistosomiasis"                                                                                                                                              
[32421] "Infection_by_Schistosoma_Bovis"                                                                                                                                       
[32422] "Infection_by_Schistosoma_Intercalatum"                                                                                                                                
[32423] "Infection_by_Schistosoma_Mattheii"                                                                                                                                    
[32424] "Ancylostomiasis_due_to_Ancylostoma_Ceylanicum"                                                                                                                        
[32425] "Intermittent_Pyrexia"                                                                                                                                                 
[32426] "Neurotic_Depression"                                                                                                                                                  
[32427] "Bone_Marrow_Neoplasm"                                                                                                                                                 
[32428] "Lytic_Metastatic_Lesion"                                                                                                                                              
[32429] "Ascending_Cholangitis"                                                                                                                                                
[32430] "Zoonotic_Bacterial_Infection"                                                                                                                                         
[32431] "Viral_Gastroenteritis"                                                                                                                                                
[32432] "Crush_Injury"                                                                                                                                                         
[32433] "Tracheal_Agenesis"                                                                                                                                                    
[32434] "Congenital_Arteriovenous_Fistula"                                                                                                                                     
[32435] "Epiphrenic_Diverticulum"                                                                                                                                              
[32436] "Hyaline_Cast_Formation"                                                                                                                                               
[32437] "Hemorrhagic_Change"                                                                                                                                                   
[32438] "Mallory_Body"                                                                                                                                                         
[32439] "True_Histiocytic_Lymphoma"                                                                                                                                            
[32440] "Acute_Necrotizing_Encephalitis"                                                                                                                                       
[32441] "Hallucinogen_Dependence_Continuous_Use"                                                                                                                               
[32442] "Hallucinogen_Dependence_Episodic_Use"                                                                                                                                 
[32443] "Cannabis_Dependence_Continuous_Use"                                                                                                                                   
[32444] "Cannabis_Dependence_Episodic_Use"                                                                                                                                     
[32445] "Cocaine_Dependence_Continuous_Use"                                                                                                                                    
[32446] "Cocaine_Dependence_Episodic_Use"                                                                                                                                      
[32447] "Respiratory_Malfunction_Arising_from_Mental_Factor"                                                                                                                   
[32448] "Conjuctival_Injury"                                                                                                                                                   
[32449] "Corneal_Injury"                                                                                                                                                       
[32450] "Congenital_Lens_Disorder"                                                                                                                                             
[32451] "Primary_Open_Angle_Glaucoma"                                                                                                                                          
[32452] "Laryngeal_Injury"                                                                                                                                                     
[32453] "Toxoplasma_Pneumonia"                                                                                                                                                 
[32454] "Slate_Pneumoconiosis"                                                                                                                                                 
[32455] "Inferior_Myocardial_Infarction"                                                                                                                                       
[32456] "Posterior_Myocardial_Infarction"                                                                                                                                      
[32457] "Silent_Myocardial_Infarction"                                                                                                                                         
[32458] "Arterial_Injury"                                                                                                                                                      
[32459] "Cytomegalovirus_Colitis"                                                                                                                                              
[32460] "Appendix_Mass"                                                                                                                                                        
[32461] "Pancreatic_Duct_Stone"                                                                                                                                                
[32462] "Trichomonas_Cystitis"                                                                                                                                                 
[32463] "Trichomonas_Balanoposthitis"                                                                                                                                          
[32464] "Diffuse_C-Cell_Hyperplasia"                                                                                                                                           
[32465] "Adrenal_Gland_Hyperplasia"                                                                                                                                            
[32466] "Adrenal_Mass"                                                                                                                                                         
[32467] "Mite-Born_Hemorrhagic_Fever"                                                                                                                                          
[32468] "Tick-Born_Hemorrhagic_Fever"                                                                                                                                          
[32469] "Rodent-Born_Hemorrhagic_Fever"                                                                                                                                        
[32470] "Flying_Phobia"                                                                                                                                                        
[32471] "Granular_Cast_Formation"                                                                                                                                              
[32472] "Vaginal_Hypoplasia"                                                                                                                                                   
[32473] "Mixed_Tumor_of_the_Parotid_Gland"                                                                                                                                     
[32474] "Intrahepatic_Cholangiocarcinoma"                                                                                                                                      
[32475] "Local_Tumor_Spread"                                                                                                                                                   
[32476] "Lipoma_of_Axilla"                                                                                                                                                     
[32477] "Phobia"                                                                                                                                                               
[32478] "Nonorganic_Insomnia"                                                                                                                                                  
[32479] "Anal_Injury"                                                                                                                                                          
[32480] "Complex_Endometrial_Hyperplasia"                                                                                                                                      
[32481] "Richter_s_Syndrome"                                                                                                                                                   
[32482] "Splenic_Marginal_Zone_B-Cell_Lymphoma_with_Villous_Lymphocytes"                                                                                                       
[32483] "Examination_Phobia"                                                                                                                                                   
[32484] "Malignant_neoplasms_of_multiple_primary_sites"                                                                                                                        
[32485] "Epithelial_Cast_Formation"                                                                                                                                            
[32486] "Fatty_Cast_Formation"                                                                                                                                                 
[32487] "Waxy_Cast_Formation"                                                                                                                                                  
[32488] "Acute_Gonococcal_Infection_of_Upper_Genitourinary_Tract"                                                                                                              
[32489] "Acute_Endocarditis"                                                                                                                                                   
[32490] "Adrenogenital_Syndrome"                                                                                                                                               
[32491] "Polycythaemia_due_to_Excess_Erythropoetin_Production"                                                                                                                 
[32492] "Enlarging_Abdomen"                                                                                                                                                    
[32493] "Cauda_Equina_Syndrome"                                                                                                                                                
[32494] "Familiar_Idiopathic_Dystonia"                                                                                                                                         
[32495] "Non-familiar_Idiopathic_Dystonia"                                                                                                                                     
[32496] "Hemophagocytic_Syndrome"                                                                                                                                              
[32497] "Acquired_Factor_IX_Deficiency"                                                                                                                                        
[32498] "Cerebral_Sarcoidosis"                                                                                                                                                 
[32499] "Hepatic_Vascular_Disorder"                                                                                                                                            
[32500] "Post-Streptococcal_Glomerulonephritis"                                                                                                                                
[32501] "Crescentic_Glomerulonephritis"                                                                                                                                        
[32502] "Mesangial_Proliferative_Glomerulonephritis"                                                                                                                           
[32503] "Bladder_Injury"                                                                                                                                                       
[32504] "Avascular_Necrosis_of_Femoral_Head"                                                                                                                                   
[32505] "Eye_Discharge"                                                                                                                                                        
[32506] "Negative_Sickling_Test"                                                                                                                                               
[32507] "Negative_Pregnancy_Test"                                                                                                                                              
[32508] "Electrocardiogram_QRS_Complex_Shortened"                                                                                                                              
[32509] "Urethral_Meatus_Stenosis"                                                                                                                                             
[32510] "Bronchial_Injury"                                                                                                                                                     
[32511] "Injury_to_Diaphragm"                                                                                                                                                  
[32512] "Gallbladder_Injury"                                                                                                                                                   
[32513] "Colon_Injury"                                                                                                                                                         
[32514] "Abnormal_Urine_Test_Result"                                                                                                                                           
[32515] "Dependence"                                                                                                                                                           
[32516] "Chemical_Injury"                                                                                                                                                      
[32517] "Crystal_Formation"                                                                                                                                                    
[32518] "Clinical_Course_of_Disease"                                                                                                                                           
[32519] "Left_Ventricular_Mass"                                                                                                                                                
[32520] "Simple_Endometrial_Hyperplasia"                                                                                                                                       
[32521] "Granulomatous_Slack_Skin_Disease"                                                                                                                                     
[32522] "Aplastic_Anemia_due_to_Radiation"                                                                                                                                     
[32523] "Aplastic_Anemia_due_to_Infection"                                                                                                                                     
[32524] "Achenbach_Syndrome"                                                                                                                                                   
[32525] "Macular_Edema"                                                                                                                                                        
[32526] "Anemia_due_to_Disorder_of_Nucleotide_Metabolism"                                                                                                                      
[32527] "Behavior-Related_Disorder"                                                                                                                                            
[32528] "Nucleated_Red_Blood_Cell_Present"                                                                                                                                     
[32529] "Anemia_due_to_Enzyme_Disorder"                                                                                                                                        
[32530] "Acute_Renal_Failure_with_Renal_Papillary_Necrosis"                                                                                                                    
[32531] "Lower_Leg_Injury"                                                                                                                                                     
[32532] "Tooth_Abscess"                                                                                                                                                        
[32533] "Aseptic_Necrosis_of_Bone"                                                                                                                                             
[32534] "Renal_Arteriovenous_Malformation"                                                                                                                                     
[32535] "Congenital_Macular_Corneal_Dystrophy"                                                                                                                                 
[32536] "Retinal_Arteriovenous_Malformation"                                                                                                                                   
[32537] "Aseptic_Necrosis_of_Femoral_Head"                                                                                                                                     
[32538] "Atrial_Tachycardia"                                                                                                                                                   
[32539] "Alveolitis"                                                                                                                                                           
[32540] "Bacterial_Gastroenteritis"                                                                                                                                            
[32541] "Cardiovascular_Injury"                                                                                                                                                
[32542] "Gingival_Injury"                                                                                                                                                      
[32543] "Lower_Back_Injury"                                                                                                                                                    
[32544] "Bone_Injury"                                                                                                                                                          
[32545] "Injury_to_Peritoneum"                                                                                                                                                 
[32546] "Thoracic_Spine_Kyphosis"                                                                                                                                              
[32547] "Esophageal_Mass"                                                                                                                                                      
[32548] "Stomach_Mass"                                                                                                                                                         
[32549] "Cancerphobia"                                                                                                                                                         
[32550] "Axillary_Lymphadenopathy"                                                                                                                                             
[32551] "Epigastric_Mass"                                                                                                                                                      
[32552] "Hilar_Mass"                                                                                                                                                           
[32553] "Chemically_Induced_Cytotoxicity"                                                                                                                                      
[32554] "Lymph_Node_Neoplasm"                                                                                                                                                  
[32555] "Toxic_Shock_Syndrome"                                                                                                                                                 
[32556] "Vascular_Purpura"                                                                                                                                                     
[32557] "Chemically_Induced_Toxicity"                                                                                                                                          
[32558] "Malignant_Bone_Marrow_Neoplasm"                                                                                                                                       
[32559] "Gastrointestinal_Infection"                                                                                                                                           
[32560] "Vascular_Proliferation"                                                                                                                                               
[32561] "Coronary_Atherosclerosis"                                                                                                                                             
[32562] "Throat_Cancer"                                                                                                                                                        
[32563] "Axillary_Lymph_Node_Involvement"                                                                                                                                      
[32564] "Abnormal_Bone_Marrow_Test_Result"                                                                                                                                     
[32565] "Brain_Mass"                                                                                                                                                           
[32566] "Endobronchial_Mass"                                                                                                                                                   
[32567] "Endocervical_Mass"                                                                                                                                                    
[32568] "Limb_Injury"                                                                                                                                                          
[32569] "Avascular_Necrosis_of_Femur"                                                                                                                                          
[32570] "Flank_Mass"                                                                                                                                                           
[32571] "Gastrointestinal_Arteriovenous_Malformation"                                                                                                                          
[32572] "Gastrointestinal_Polyp"                                                                                                                                               
[32573] "Avascular_Necrosis_of_Humerus"                                                                                                                                        
[32574] "Lumbar_Spine_Kyphosis"                                                                                                                                                
[32575] "Septal_Myocardial_Infarction"                                                                                                                                         
[32576] "Nasal_Mass"                                                                                                                                                           
[32577] "Lymph_Node_Mass"                                                                                                                                                      
[32578] "Periodontal_Infection"                                                                                                                                                
[32579] "Vaginal_Abscess"                                                                                                                                                      
[32580] "White_Blood_Cell_Count_Increased"                                                                                                                                     
[32581] "Hemolytic_Anemia_due_to_Disseminated_Intravascular_Coagulation"                                                                                                       
[32582] "Chronic_Insomnia"                                                                                                                                                     
[32583] "Familiar_Dystonia"                                                                                                                                                    
[32584] "Wolf-Hirschhorn_Syndrome"                                                                                                                                             
[32585] "Lymph_Node_Involvement"                                                                                                                                               
[32586] "Thrombocytosis"                                                                                                                                                       
[32587] "Pulmonary_Vascular_Disorder"                                                                                                                                          
[32588] "Portal_Cirrhosis"                                                                                                                                                     
[32589] "Nephrotic_Syndrome_with_Lesion_of_Focal_Glomerulosclerosis"                                                                                                           
[32590] "Nephrotic_Syndrome_with_Lesion_of_Segmental_Hyalinosis"                                                                                                               
[32591] "Nephrotic_Syndrome_with_Lesion_of_Endothelial_Glomerulonephritis"                                                                                                     
[32592] "Nephrotic_Syndrome_with_Lesion_of_Hypocomplementemic_Glomerulonephritis"                                                                                              
[32593] "Nephrotic_Syndrome_with_Lesion_of_Persistent_Glomerulonephritis"                                                                                                      
[32594] "Nephrotic_Syndrome_with_Lesion_of_Lobular_Glomerulonephritis"                                                                                                         
[32595] "Nephrotic_Syndrome_with_Lesion_of_Mesangiocapillary_Glomerulonephritis"                                                                                               
[32596] "Nephrotic_Syndrome_with_Lesion_of_Minimal_Change_Glomerulonephritis"                                                                                                  
[32597] "Hyperkeratosis"                                                                                                                                                       
[32598] "Traumatic_Encephalopathy"                                                                                                                                             
[32599] "Arteriolosclerosis"                                                                                                                                                   
[32600] "Myocardial_Disorder"                                                                                                                                                  
[32601] "Acroosteolysis"                                                                                                                                                       
[32602] "Dysphasia"                                                                                                                                                            
[32603] "Yellow_Fever_Virus_Infection"                                                                                                                                         
[32604] "Monoclonal_Gammopathy"                                                                                                                                                
[32605] "Hypoxic_Encephalopathy"                                                                                                                                               
[32606] "Acute_Poliomyelitis"                                                                                                                                                  
[32607] "Cardiovascular_System_Finding"                                                                                                                                        
[32608] "Abnormal_Blood_and_Hematology_Test_Result"                                                                                                                            
[32609] "Salivary_Gland_Sebaceous_Lymphadenoma"                                                                                                                                
[32610] "Childhood_Botryoid-Type_Embryonal_Rhabdomyosarcoma_of_the_Vagina"                                                                                                     
[32611] "Metastatic_Malignant_Neoplasm_to_the_Cervix"                                                                                                                          
[32612] "Tall_Cell_Variant_Papillary_Carcinoma"                                                                                                                                
[32613] "Complex_Endometrial_Hyperplasia_with_Atypia"                                                                                                                          
[32614] "Rare_Cancer-associated_Syndrome"                                                                                                                                      
[32615] "Neuroepithelial_Perineurial_and_Schwann_Cell_Neoplasm"                                                                                                                
[32616] "Atypical_Lymphocytes_Present"                                                                                                                                         
[32617] "Hurthle_Cell_Metaplasia"                                                                                                                                              
[32618] "Astler-Coller_B1_Colon_Carcinoma"                                                                                                                                     
[32619] "Chemically_Induced_Cardiotoxicity"                                                                                                                                    
[32620] "Chemically_Induced_Urinary_Tract_Toxicity"                                                                                                                            
[32621] "Progressive_Disease"                                                                                                                                                  
[32622] "Childhood_Botryoid-Type_Embryonal_Rhabdomyosarcoma"                                                                                                                   
[32623] "Chemically_Induced_Irreversible_Toxicity"                                                                                                                             
[32624] "Mucocutaneous_Candidiasis"                                                                                                                                            
[32625] "Traumatic_Hemorrhage"                                                                                                                                                 
[32626] "Acalculous_Cholecystitis"                                                                                                                                             
[32627] "Acute_Acalculous_Cholecystitis"                                                                                                                                       
[32628] "Hemorrhagic_Complication_of_Pregnancy"                                                                                                                                
[32629] "Initial_Insomnia"                                                                                                                                                     
[32630] "Middle_Insomnia"                                                                                                                                                      
[32631] "Low_Frequency_Deafness"                                                                                                                                               
[32632] "Erythrophagocytosis"                                                                                                                                                  
[32633] "Mixed_Stone"                                                                                                                                                          
[32634] "Lateral_Myocardial_Infarction"                                                                                                                                        
[32635] "Acute_Diffuse_Glomerulonephritis"                                                                                                                                     
[32636] "Trichomonas_Cervicitis"                                                                                                                                               
[32637] "Cardiac_Sarcoidosis"                                                                                                                                                  
[32638] "Cryptococcal_Gastroenteritis"                                                                                                                                         
[32639] "Cryptosporidial_Gastroenteritis"                                                                                                                                      
[32640] "Emphysematous_Cholecystitis"                                                                                                                                          
[32641] "Congenital_Spondylolysis"                                                                                                                                             
[32642] "Maternal_Complication_of_Pregnancy"                                                                                                                                   
[32643] "Vascular_Hemorrhagic_Disorder"                                                                                                                                        
[32644] "Dental_Developmental_Disorder"                                                                                                                                        
[32645] "Dental_Surface_Disorder"                                                                                                                                              
[32646] "Dental_Pain_and_Sensation_Disorder"                                                                                                                                   
[32647] "Congenital_Adrenal_Gland_Disorder"                                                                                                                                    
[32648] "Skin_Ischemic_Condition"                                                                                                                                              
[32649] "Visual_Field_Disorder"                                                                                                                                                
[32650] "Chronic_Metabolic_Polyneuropathy"                                                                                                                                     
[32651] "Chronic_Toxic_Polyneuropathy"                                                                                                                                         
[32652] "Sleep_Disorder_due_to_General_Medical_Condition"                                                                                                                      
[32653] "Glomerular_Vascular_Disorder"                                                                                                                                         
[32654] "Cartilage_Injury"                                                                                                                                                     
[32655] "Blood_Alkaline_Phosphatase_Increased"                                                                                                                                 
[32656] "Aggravated_Colitis"                                                                                                                                                   
[32657] "Exacerbated_Insomnia"                                                                                                                                                 
[32658] "Diabetic_Vascular_Disorder"                                                                                                                                           
[32659] "Hepatic_Arteriovenous_Malformation"                                                                                                                                   
[32660] "Negative_Schumm_s_Test"                                                                                                                                               
[32661] "AIDS_Phobia"                                                                                                                                                          
[32662] "Sputum_Excretion_Difficulty"                                                                                                                                          
[32663] "Papillary_Conjunctivitis"                                                                                                                                             
[32664] "Post_Abortion_Hemorrhage"                                                                                                                                             
[32665] "Iris_Vascular_Disorder"                                                                                                                                               
[32666] "Herpes_Zoster_Dermatitis"                                                                                                                                             
[32667] "Herpes_Simplex_Dermatitis"                                                                                                                                            
[32668] "Gonococcal_Infection_of_Genitourinary_Tract"                                                                                                                          
[32669] "Caustic_Injury"                                                                                                                                                       
[32670] "Aortic_Injury"                                                                                                                                                        
[32671] "Enterovirus_Gastroenteritis"                                                                                                                                          
[32672] "Retinal_Dystrophy"                                                                                                                                                    
[32673] "Spinal_Vascular_Disorder"                                                                                                                                             
[32674] "Negative_Skin_Test"                                                                                                                                                   
[32675] "Criminal_Injury"                                                                                                                                                      
[32676] "Submandibular_Duct_Stone"                                                                                                                                             
[32677] "Domestic_Injury"                                                                                                                                                      
[32678] "Periapical_Dental_Abscess"                                                                                                                                            
[32679] "Fredrickson_Type_I_Lipidemia"                                                                                                                                         
[32680] "Negative_Patch_Test"                                                                                                                                                  
[32681] "C_Sordelli_Colitis"                                                                                                                                                   
[32682] "Chronic_Candidiasis"                                                                                                                                                  
[32683] "Lower_Ribs_Pain"                                                                                                                                                      
[32684] "Type_IIb_Hyperlipidemia"                                                                                                                                              
[32685] "Increased_Sputum_Excretion"                                                                                                                                           
[32686] "Femoral_Hernia_with_Obstruction_without_mention_of_Gangrene"                                                                                                          
[32687] "Umbilical_Hernia_with_Obstruction_without_mention_of_Gangrene"                                                                                                        
[32688] "Hernia_with_Obstruction_without_mention_of_Gangrene"                                                                                                                  
[32689] "Ventral_Hernia_with_Obstruction_without_mention_of_Gangrene"                                                                                                          
[32690] "Corrosive_Injury"                                                                                                                                                     
[32691] "Fredrickson_Type_III_Lipidemia"                                                                                                                                       
[32692] "Fredrickson_Type_V_Lipidemia"                                                                                                                                         
[32693] "Pancreatic_Injury"                                                                                                                                                    
[32694] "Insomnia_due_to_Organic_Factor"                                                                                                                                       
[32695] "Non-Resectable_Primary_Hepatic_Malignant_Neoplasm"                                                                                                                    
[32696] "Hydroxyproline_Urine_Increased"                                                                                                                                       
[32697] "Upper_Respiratory_Tract_Infection"                                                                                                                                    
[32698] "Post-Procedural_Pain"                                                                                                                                                 
[32699] "Acquired_Macrocephaly"                                                                                                                                                
[32700] "Congenital_Macrocephaly"                                                                                                                                              
[32701] "Carcinomatous_Ascites"                                                                                                                                                
[32702] "Normal_Blood_Test_Result"                                                                                                                                             
[32703] "Post_Procedural_Hemorrhage"                                                                                                                                           
[32704] "Normal_Phenolsulfonphthalein_Test"                                                                                                                                    
[32705] "Congenital_Dental_Disorder"                                                                                                                                           
[32706] "Anemia_due_to_Chronic_Disorder"                                                                                                                                       
[32707] "Cytomegalovirus_Gastroenteritis"                                                                                                                                      
[32708] "Chest_Wall_Cyst"                                                                                                                                                      
[32709] "Tumor_Associated_Fever"                                                                                                                                               
[32710] "Injury_Asphyxation"                                                                                                                                                   
[32711] "Ocular_Vascular_Disorder"                                                                                                                                             
[32712] "Neutropenic_Fever"                                                                                                                                                    
[32713] "Ureter_Abscess"                                                                                                                                                       
[32714] "Post-biopsy_Pain"                                                                                                                                                     
[32715] "Non-Proliferative_Diabetic_Retinopathy"                                                                                                                               
[32716] "Abdominal_Infection"                                                                                                                                                  
[32717] "Phobia_of_Driving"                                                                                                                                                    
[32718] "Bursa_Injury"                                                                                                                                                         
[32719] "Posterolateral_Myocardial_Infarction"                                                                                                                                 
[32720] "Inferolateral_Myocardial_Infarction"                                                                                                                                  
[32721] "Astler-Coller_B2_Colon_Carcinoma"                                                                                                                                     
[32722] "Recurrent_Malignant_Neoplasm_of_Salivary_Gland"                                                                                                                       
[32723] "Localized_Malignant_Gallbladder_Neoplasm"                                                                                                                             
[32724] "Negative_Test_Result"                                                                                                                                                 
[32725] "Positive_Test_Result"                                                                                                                                                 
[32726] "Localized_Pagetoid_Reticulosis"                                                                                                                                       
[32727] "Mycosis_Fungoides-Associated_Follicular_Mucinosis"                                                                                                                    
[32728] "Immunodeficiency-Related_Disorder"                                                                                                                                    
[32729] "Parotid_Gland_Mucosa-Associated_Lymphoid_Tissue_Lymphoma"                                                                                                             
[32730] "Breast_Mucosa-Associated_Lymphoid_Tissue_Lymphoma"                                                                                                                    
[32731] "Ocular_Adnexae_Mucosa-Associated_Lymphoid_Tissue_Lymphoma"                                                                                                            
[32732] "Eye_Lymphoma"                                                                                                                                                         
[32733] "Mixed_Tumor_of_the_Salivary_Gland"                                                                                                                                    
[32734] "Posterior_Pharyngeal_Wall_Carcinoma"                                                                                                                                  
[32735] "Posterior_Pharyngeal_Wall_Squamous_Cell_Carcinoma"                                                                                                                    
[32736] "Stage_IVA_Major_Salivary_Gland_Carcinoma"                                                                                                                             
[32737] "Stage_IVB_Major_Salivary_Gland_Carcinoma"                                                                                                                             
[32738] "Stage_IVC_Major_Salivary_Gland_Carcinoma"                                                                                                                             
[32739] "Epiglottic_Carcinoma"                                                                                                                                                 
[32740] "Benign_Uvula_Neoplasm"                                                                                                                                                
[32741] "Diffuse_Infiltrative_Lymphocytosis_Syndrome"                                                                                                                          
[32742] "Salivary_Gland_Myoepithelial_Carcinoma"                                                                                                                               
[32743] "Salivary_Gland_Epithelial_Myoepithelial_Carcinoma"                                                                                                                    
[32744] "Salivary_Gland_Polymorphous_Low-Grade_Adenocarcinoma"                                                                                                                 
[32745] "Salivary_Gland_Anaplastic_Small_Cell_Carcinoma"                                                                                                                       
[32746] "Acute_Contagious_Conjunctivitis"                                                                                                                                      
[32747] "Closed_Dislocation"                                                                                                                                                   
[32748] "Exudative_Glomerulonephritis"                                                                                                                                         
[32749] "Focal_Embolic_Glomerulonephritis"                                                                                                                                     
[32750] "Stone"                                                                                                                                                                
[32751] "Aagenaes_Syndrome"                                                                                                                                                    
[32752] "Allgrove_Syndrome"                                                                                                                                                    
[32753] "Testicular_Teratoma_with_Somatic-Type_Malignancy"                                                                                                                     
[32754] "Follicular_Bronchitis_Bronchiolitis"                                                                                                                                  
[32755] "Nodular_Lymphoid_Hyperplasia_of_Lung"                                                                                                                                 
[32756] "Idiopathic_Interstitial_Pneumonia"                                                                                                                                    
[32757] "Usual_Interstitial_Pneumonia"                                                                                                                                         
[32758] "Idiopathic_Pulmonary_Fibrosis"                                                                                                                                        
[32759] "Nonspecific_Interstitial_Pneumonia"                                                                                                                                   
[32760] "Undifferentiated_Thymic_Carcinoma"                                                                                                                                    
[32761] "Genitourinary_System_Infection"                                                                                                                                       
[32762] "Trichomonas_Infection"                                                                                                                                                
[32763] "Paraphrenia"                                                                                                                                                          
[32764] "Third_Degree_Uterine_Prolapse"                                                                                                                                        
[32765] "Nasopharyngeal_Disorder"                                                                                                                                              
[32766] "Dislocation"                                                                                                                                                          
[32767] "Grade_II_Neuroendocrine_Carcinoma"                                                                                                                                    
[32768] "Grade_III_Neuroendocrine_Carcinoma"                                                                                                                                   
[32769] "Grade_I_Neuroendocrine_Carcinoma"                                                                                                                                     
[32770] "Congenital_Cardiovascular_Disorder"                                                                                                                                   
[32771] "Congenital_Cardiovascular_Abnormality"                                                                                                                                
[32772] "Gonococcal_Infection"                                                                                                                                                 
[32773] "Hearing_Loss"                                                                                                                                                         
[32774] "High_Frequency_Deafness"                                                                                                                                              
[32775] "Head_and_Neck_Infection"                                                                                                                                              
[32776] "Small_Cell_Undifferentiated_Salivary_Gland_Carcinoma"                                                                                                                 
[32777] "Large_Cell_Undifferentiated_Salivary_Gland_Carcinoma"                                                                                                                 
[32778] "Lymphoepithelial_Salivary_Gland_Carcinoma"                                                                                                                            
[32779] "Salivary_Gland_Adenosquamous_Carcinoma"                                                                                                                               
[32780] "Salivary_Gland_Sebaceous_Adenoma"                                                                                                                                     
[32781] "Skin_Appendage_Sebaceous_Adenoma"                                                                                                                                     
[32782] "Non-Neoplastic_Vascular_Disorder"                                                                                                                                     
[32783] "Non-Neoplastic_Heart_Disorder"                                                                                                                                        
[32784] "Thoracic_Disorder"                                                                                                                                                    
[32785] "Non-Neoplastic_Thoracic_Disorder"                                                                                                                                     
[32786] "Sternal_Disorder"                                                                                                                                                     
[32787] "Chest_Wall_Disorder"                                                                                                                                                  
[32788] "Axillary_Disorder"                                                                                                                                                    
[32789] "Non-Neoplastic_Axillary_Disorder"                                                                                                                                     
[32790] "Metastatic_Malignant_Neoplasm_to_the_Axilla"                                                                                                                          
[32791] "Axillary_Neoplasm"                                                                                                                                                    
[32792] "Benign_Axillary_Neoplasm"                                                                                                                                             
[32793] "Non-Neoplastic_Sternal_Disorder"                                                                                                                                      
[32794] "Non-Neoplastic_Chest_Wall_Disorder"                                                                                                                                   
[32795] "Non-Neoplastic_Tracheal_Disorder"                                                                                                                                     
[32796] "Tracheal_Atresia"                                                                                                                                                     
[32797] "Non-Neoplastic_Respiratory_Disorder"                                                                                                                                  
[32798] "Stage_IIIB_Small_Cell_Lung_Carcinoma_with_Pleural_Effusion"                                                                                                           
[32799] "Stage_IIIB_Small_Cell_Lung_Carcinoma_without_Pleural_Effusion"                                                                                                        
[32800] "Stage_0_Large_Cell_Lung_Carcinoma"                                                                                                                                    
[32801] "Metastasizing_Mixed_Tumor_of_the_Salivary_Gland"                                                                                                                      
[32802] "Arthropathy"                                                                                                                                                          
[32803] "Transient_Arthropathy"                                                                                                                                                
[32804] "Traumatic_Arthropathy"                                                                                                                                                
[32805] "Traumatic_Arthritis"                                                                                                                                                  
[32806] "Wernicke-Korsakoff_Syndrome"                                                                                                                                          
[32807] "Histiocytoma"                                                                                                                                                         
[32808] "Normal_Laboratory_Test_Result"                                                                                                                                        
[32809] "Generalized_Atherosclerosis"                                                                                                                                          
[32810] "Atherosclerosis"                                                                                                                                                      
[32811] "Generalized_Arteriosclerosis"                                                                                                                                         
[32812] "Monckeberg_Arteriosclerosis"                                                                                                                                          
[32813] "Atherosclerotic_Cardiovascular_Disease"                                                                                                                               
[32814] "Vitamin_Deficiency_Disorder"                                                                                                                                          
[32815] "Bile_Duct_Stone"                                                                                                                                                      
[32816] "Non-Neoplastic_Biliary_Tract_Disorder"                                                                                                                                
[32817] "Ciliary_Body_Disorder"                                                                                                                                                
[32818] "Non-Neoplastic_Uveal_Disorder"                                                                                                                                        
[32819] "Pediculosis_Pubis"                                                                                                                                                    
[32820] "Gastrointestinal_Stromal_Tumor_of_the_Gastrointestinal_Tract"                                                                                                         
[32821] "Non-Neoplastic_Dental_Disorder"                                                                                                                                       
[32822] "Epitheliod_Cell_Uveal_Melanoma"                                                                                                                                       
[32823] "Mixed_Cell_Uveal_Melanoma"                                                                                                                                            
[32824] "Choroid_Mixed_Cell_Melanoma"                                                                                                                                          
[32825] "Ciliary_Body_Mixed_Cell_Melanoma"                                                                                                                                     
[32826] "Non-Neoplastic_Hair_Disorder"                                                                                                                                         
[32827] "Muscle_Soreness"                                                                                                                                                      
[32828] "Interstitial_Myocarditis"                                                                                                                                             
[32829] "Unstable_Personality"                                                                                                                                                 
[32830] "Hypercellular_Bone_Marrow"                                                                                                                                            
[32831] "Lower_Thigh_Pain"                                                                                                                                                     
[32832] "Congenital_Alopecia"                                                                                                                                                  
[32833] "Passive-Aggressive_Behavior"                                                                                                                                          
[32834] "Xanthogranulomatous_Cholecystitis"                                                                                                                                    
[32835] "Femoropopliteal_Occlusive_Disease"                                                                                                                                    
[32836] "Pagetoid_Reticulosis"                                                                                                                                                 
[32837] "Acrofacial_Dysostosis"                                                                                                                                                
[32838] "Acute_Hemorrhagic_Encephalitis"                                                                                                                                       
[32839] "Demyelinating_Encephalopathy"                                                                                                                                         
[32840] "Anti-Basement_Membrane_Glomerulonephritis"                                                                                                                            
[32841] "Diffuse_Glomerulonephritis"                                                                                                                                           
[32842] "Immune_Complex_Glomerulonephritis"                                                                                                                                    
[32843] "Subacute_Glomerulonephritis"                                                                                                                                          
[32844] "Postpartum_Hypertension"                                                                                                                                              
[32845] "Zoonotic_Infection"                                                                                                                                                   
[32846] "Conditioned_Insomnia"                                                                                                                                                 
[32847] "Ancylostomiasis"                                                                                                                                                      
[32848] "Acute_Interstitial_Pneumonia"                                                                                                                                         
[32849] "Hypercalcemic_Sarcoidosis"                                                                                                                                            
[32850] "Abstinence_Syndrome"                                                                                                                                                  
[32851] "Achard_Syndrome"                                                                                                                                                      
[32852] "Acroparesthesia_Syndrome"                                                                                                                                             
[32853] "Adherence_Syndrome"                                                                                                                                                   
[32854] "Malignant_Lymph_Node_Neoplasm"                                                                                                                                        
[32855] "Hematopoietic_System_Neoplasm"                                                                                                                                        
[32856] "Hematopoietic_System_Disorder"                                                                                                                                        
[32857] "Granulocytic_Sarcoma"                                                                                                                                                 
[32858] "Monoblastic_Sarcoma"                                                                                                                                                  
[32859] "Blastic_Granulocytic_Sarcoma"                                                                                                                                         
[32860] "Immature_Granulocytic_Sarcoma"                                                                                                                                        
[32861] "Differentiated_Granulocytic_Sarcoma"                                                                                                                                  
[32862] "Reticulin_Fibrosis_of_the_Bone_Marrow"                                                                                                                                
[32863] "Collagen_Fibrosis_of_the_Bone_Marrow"                                                                                                                                 
[32864] "Perivascular_Fibrosis"                                                                                                                                                
[32865] "Splenic_Disorder"                                                                                                                                                     
[32866] "Amputation_Neuroma"                                                                                                                                                   
[32867] "Megaloblastic_Erythroid_Hyperplasia"                                                                                                                                  
[32868] "Foveolar_Hyperplasia"                                                                                                                                                 
[32869] "Riedel_s_Fibrosing_Thyroiditis"                                                                                                                                       
[32870] "Subacute_Granulomatous_Thyroiditis"                                                                                                                                   
[32871] "Subacute_Lymphocytic_Thyroiditis"                                                                                                                                     
[32872] "Columnar_Cell_Variant_Papillary_Carcinoma"                                                                                                                            
[32873] "Carcinosarcoma_of_the_Salivary_Gland"                                                                                                                                 
[32874] "Parotid_Gland_Carcinosarcoma"                                                                                                                                         
[32875] "Salivary_Gland_Cystadenoma"                                                                                                                                           
[32876] "Salivary_Gland_Intraductal_Papilloma"                                                                                                                                 
[32877] "Salivary_Gland_Inverted_Ductal_Papilloma"                                                                                                                             
[32878] "Salivary_Gland_Sialadenoma_Papilliferum"                                                                                                                              
[32879] "Salivary_Gland_Sialoblastoma"                                                                                                                                         
[32880] "Adrenal_Medullary_Hyperplasia"                                                                                                                                        
[32881] "Salivary_Gland_Ductal_Papilloma"                                                                                                                                      
[32882] "Intraepithelial_Melanocytic_Hyperplasia"                                                                                                                              
[32883] "Melanocytic_Dysplasia"                                                                                                                                                
[32884] "Microaneurysm"                                                                                                                                                        
[32885] "Traumatic_Aneurysm"                                                                                                                                                   
[32886] "Radiation-Induced_Vascular_Disease"                                                                                                                                   
[32887] "Basal_Cell_Hyperplasia"                                                                                                                                               
[32888] "Columnar_Metaplasia"                                                                                                                                                  
[32889] "Liver_Cell_Dysplasia"                                                                                                                                                 
[32890] "Large_Liver_Cell_Dysplasia"                                                                                                                                           
[32891] "Small_Liver_Cell_Dysplasia"                                                                                                                                           
[32892] "Head_and_Neck_Carcinoma"                                                                                                                                              
[32893] "Grade_1_Conventional_Clear_Cell_Renal_Cell_Carcinoma"                                                                                                                 
[32894] "Grade_2_Conventional_Clear_Cell_Renal_Cell_Carcinoma"                                                                                                                 
[32895] "Grade_3_Conventional_Clear_Cell_Renal_Cell_Carcinoma"                                                                                                                 
[32896] "Grade_4_Conventional_Clear_Cell_Renal_Cell_Carcinoma"                                                                                                                 
[32897] "Squamous_Hyperplasia"                                                                                                                                                 
[32898] "Mesonephric_Hyperplasia"                                                                                                                                              
[32899] "Stromal_Hyperplasia"                                                                                                                                                  
[32900] "Stromal_Metaplasia"                                                                                                                                                   
[32901] "Osseous_Metaplasia"                                                                                                                                                   
[32902] "Cartilagenous_Metaplasia"                                                                                                                                             
[32903] "Mesothelial_Hyperplasia"                                                                                                                                              
[32904] "Adrenal_Pheochromocytoma"                                                                                                                                             
[32905] "Malignant_Adrenal_Pheochromocytoma"                                                                                                                                   
[32906] "Extra-Adrenal_Pheochromocytoma"                                                                                                                                       
[32907] "Malignant_Extra-Adrenal_Pheochromocytoma"                                                                                                                             
[32908] "Normal_Urine_Test_Result"                                                                                                                                             
[32909] "Morphologic_Finding"                                                                                                                                                  
[32910] "Maxillary_Sinus_Cholesteatoma"                                                                                                                                        
[32911] "Radiologic_Finding"                                                                                                                                                   
[32912] "Conventional_Osteosarcoma"                                                                                                                                            
[32913] "Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor_of_Bone"                                                                                                   
[32914] "Iatrogenic_Kaposi_s_Sarcoma"                                                                                                                                          
[32915] "Endemic_African_Kaposi_s_Sarcoma"                                                                                                                                     
[32916] "Bronchogenic_Carcinoma"                                                                                                                                               
[32917] "Childhood_Intracranial_Neoplasm"                                                                                                                                      
[32918] "Abnormal_Hematology_Test_Result"                                                                                                                                      
[32919] "Monoclonal_Paraproteinemia"                                                                                                                                           
[32920] "Anisochromasia"                                                                                                                                                       
[32921] "Blast_Cells_Present"                                                                                                                                                  
[32922] "Blast_Cells_Present_in_Peripheral_Blood"                                                                                                                              
[32923] "Hereditary_Elliptocytosis"                                                                                                                                            
[32924] "Blast_Cells_Increased_in_Bone_Marrow"                                                                                                                                 
[32925] "Monoclonal_Hypergammaglobulinemia"                                                                                                                                    
[32926] "Polyclonal_Hypergammaglobulinemia"                                                                                                                                    
[32927] "Morphologic_Architectural_Pattern"                                                                                                                                    
[32928] "Herringbone_Growth_Pattern"                                                                                                                                           
[32929] "Storiform_Growth_Pattern"                                                                                                                                             
[32930] "Whorling_Growth_Pattern"                                                                                                                                              
[32931] "Plexiform_Growth_Pattern"                                                                                                                                             
[32932] "Lobulated_Growth_Pattern"                                                                                                                                             
[32933] "Nested_Proliferation"                                                                                                                                                 
[32934] "Pagetoid_Proliferation"                                                                                                                                               
[32935] "Junctional_Proliferation"                                                                                                                                             
[32936] "Compound_Growth_Pattern"                                                                                                                                              
[32937] "Dermal_Growth_Pattern"                                                                                                                                                
[32938] "Radial_Growth_Phase"                                                                                                                                                  
[32939] "Vertical_Growth_Phase"                                                                                                                                                
[32940] "Nodular_Pattern"                                                                                                                                                      
[32941] "Multinodular_Pattern"                                                                                                                                                 
[32942] "Pseudofollicular_Pattern"                                                                                                                                             
[32943] "Interfollicular_Pattern"                                                                                                                                              
[32944] "Diffuse_Pattern"                                                                                                                                                      
[32945] "Nodular_and_Diffuse_Pattern"                                                                                                                                          
[32946] "Angiocentric_Pattern"                                                                                                                                                 
[32947] "Angiodestructive_Pattern"                                                                                                                                             
[32948] "Biphasic_Pattern"                                                                                                                                                     
[32949] "Monophasic_Pattern"                                                                                                                                                   
[32950] "Antoni_A_Pattern"                                                                                                                                                     
[32951] "Antoni_B_Pattern"                                                                                                                                                     
[32952] "Papillary_Pattern"                                                                                                                                                    
[32953] "Pseudopapillary_Pattern"                                                                                                                                              
[32954] "Trabecular_Pattern"                                                                                                                                                   
[32955] "Gyriform_Trabecular_Pattern"                                                                                                                                          
[32956] "Macrotrabecular_Pattern"                                                                                                                                              
[32957] "Insular_Pattern"                                                                                                                                                      
[32958] "Alveolar_Pattern"                                                                                                                                                     
[32959] "Organoid_Pattern"                                                                                                                                                     
[32960] "Cylindromatous_Pattern"                                                                                                                                               
[32961] "Cribriform_Pattern"                                                                                                                                                   
[32962] "Pseudoglandular_Pattern"                                                                                                                                              
[32963] "Acinar_Pattern"                                                                                                                                                       
[32964] "Compact_Pattern"                                                                                                                                                      
[32965] "Scirrhous_Pattern"                                                                                                                                                    
[32966] "Tubular_Pattern"                                                                                                                                                      
[32967] "Glomeruloid_Pattern"                                                                                                                                                  
[32968] "Syncytial_Pattern"                                                                                                                                                    
[32969] "Triphasic_Pattern"                                                                                                                                                    
[32970] "Glandular_Pattern"                                                                                                                                                    
[32971] "Endodermal_Sinus_Pattern"                                                                                                                                             
[32972] "Reticular_Pattern"                                                                                                                                                    
[32973] "Sex_Cord-Like_Pattern"                                                                                                                                                
[32974] "Distantly_Metastatic_Neoplasm"                                                                                                                                        
[32975] "Locally_Metastatic_Neoplasm"                                                                                                                                          
[32976] "Sessile_Lesion"                                                                                                                                                       
[32977] "Pedunculated_Lesion"                                                                                                                                                  
[32978] "Rhabdomyosarcomatous_Differentiation"                                                                                                                                 
[32979] "Epithelioid_Differentiation"                                                                                                                                          
[32980] "Tumor_Vascular_Invasion"                                                                                                                                              
[32981] "Rosette_Formation"                                                                                                                                                    
[32982] "Flexner-Wintersteiner_Rosette_Formation"                                                                                                                              
[32983] "Homer-Right_Rosette_Formation"                                                                                                                                        
[32984] "Pseudorosette_Formation"                                                                                                                                              
[32985] "Ependymal_Rosette_Formation"                                                                                                                                          
[32986] "Pineocytomatous_Rosette_Formation"                                                                                                                                    
[32987] "Multilayered_Rosette_Formation"                                                                                                                                       
[32988] "Cementum_Formation"                                                                                                                                                   
[32989] "Dentin_Formation"                                                                                                                                                     
[32990] "Enamel_Formation"                                                                                                                                                     
[32991] "Fleurette_Formation"                                                                                                                                                  
[32992] "Squamous_Pearl_Formation"                                                                                                                                             
[32993] "Arias-Stella_Reaction"                                                                                                                                                
[32994] "Hydropic_Villous_Change"                                                                                                                                              
[32995] "Stromal_Invasion"                                                                                                                                                     
[32996] "Absence_of_Stromal_Invasion"                                                                                                                                          
[32997] "Fibrinoid_Necrosis"                                                                                                                                                   
[32998] "Tumor_Cell_Necrosis"                                                                                                                                                  
[32999] "Comedo-Like_Necrosis"                                                                                                                                                 
[33000] "Mitotic_Activity"                                                                                                                                                     
[33001] "High_Mitotic_Activity"                                                                                                                                                
[33002] "Low_Mitotic_Activity"                                                                                                                                                 
[33003] "Atypical_Mitotic_Figures"                                                                                                                                             
[33004] "Vascular_Morphologic_Change"                                                                                                                                          
[33005] "Cavernous-Like_Vascular_Space_Formation"                                                                                                                              
[33006] "Cavernous_Lymphatic_Space_Formation"                                                                                                                                  
[33007] "Dilated_Thick-Walled_Vascular_Space_Formation"                                                                                                                        
[33008] "Dilated_Thin-Walled_Vascular_Space_Formation"                                                                                                                         
[33009] "Intravascular_Thrombus_Formation"                                                                                                                                     
[33010] "Thin-Walled_Branching_Vascular_Pattern"                                                                                                                               
[33011] "Staghorn_Configuration"                                                                                                                                               
[33012] "Angiectoid_Space_Formation"                                                                                                                                           
[33013] "Small_Capillary-Sized_Vascular_Proliferation"                                                                                                                         
[33014] "Irregular_Vascular_Channel_Formation"                                                                                                                                 
[33015] "Sinusoidal_Vascular_Channel_Formation"                                                                                                                                
[33016] "Arborizing_Vascular_Channel_Formation"                                                                                                                                
[33017] "Vascular_Channel_Formation"                                                                                                                                           
[33018] "Lobular_Capillary_Arrangement"                                                                                                                                        
[33019] "Inflammatory_Infiltrate"                                                                                                                                              
[33020] "Acute_Inflammatory_Infiltrate"                                                                                                                                        
[33021] "Chronic_Inflammatory_Infiltrate"                                                                                                                                      
[33022] "Eosinophilic_Infiltrate"                                                                                                                                              
[33023] "Neutrophilic_Infiltrate"                                                                                                                                              
[33024] "Lymphocytic_Infiltrate"                                                                                                                                               
[33025] "Lymphoplasmacytic_Infiltrate"                                                                                                                                         
[33026] "Hemophagocytosis"                                                                                                                                                     
[33027] "Onion-Skinning_Appearance"                                                                                                                                            
[33028] "Emperipolesis"                                                                                                                                                        
[33029] "Metaplastic_Bone_Formation"                                                                                                                                           
[33030] "Nuclear_Atypia_Present"                                                                                                                                               
[33031] "Hemosiderin_Deposition"                                                                                                                                               
[33032] "Red_Blood_Cells_Extravasation"                                                                                                                                        
[33033] "Dystrophic_Calcification"                                                                                                                                             
[33034] "Neoplastic_Bone_Formation"                                                                                                                                            
[33035] "Pseudoangiomatoid_Space_Formation"                                                                                                                                    
[33036] "Ringed_Sideroblasts_Present"                                                                                                                                          
[33037] "Stromal_Change"                                                                                                                                                       
[33038] "Vascular_Collagenous_Stroma_Formation"                                                                                                                                
[33039] "Myxoid_Stroma_Formation"                                                                                                                                              
[33040] "Mucinous_Stroma_Formation"                                                                                                                                            
[33041] "Hyalinized_Stroma_Formation"                                                                                                                                          
[33042] "Fibromyxoid_Stroma_Formation"                                                                                                                                         
[33043] "Chondromyxoid_Stroma_Formation"                                                                                                                                       
[33044] "Desmoplastic_Stroma_Formation"                                                                                                                                        
[33045] "Fibroblastic_Stroma_Formation"                                                                                                                                        
[33046] "Edematous_Stroma_Formation"                                                                                                                                           
[33047] "Stromal_Hemorrhage_Present"                                                                                                                                           
[33048] "Cast_Formation"                                                                                                                                                       
[33049] "Erythrocytic_Cast_Formation"                                                                                                                                          
[33050] "Leukocytic_Cast_Formation"                                                                                                                                            
[33051] "Central_Scar"                                                                                                                                                         
[33052] "Decidual_Reaction"                                                                                                                                                    
[33053] "Nodular_Neoplasm"                                                                                                                                                     
[33054] "Bid-Like_Elastic_Fiber"                                                                                                                                               
[33055] "Russell_Body"                                                                                                                                                         
[33056] "Asbestos_Body"                                                                                                                                                        
[33057] "Michaelis-Gutmann_Body"                                                                                                                                               
[33058] "Nuclear_Inclusion"                                                                                                                                                    
[33059] "Ground_Glass_Nuclear_Inclusion"                                                                                                                                       
[33060] "Cowdry_Type_A_Eosinophilic_Intranuclear_Inclusion"                                                                                                                    
[33061] "Dutcher_Body"                                                                                                                                                         
[33062] "Corpora_Amylacea"                                                                                                                                                     
[33063] "Verocay_Body"                                                                                                                                                         
[33064] "Call_Exner_Body"                                                                                                                                                      
[33065] "Stary_Sky_Pattern"                                                                                                                                                    
[33066] "Anaplastic_Malignant_Neoplasm"                                                                                                                                        
[33067] "Diffuse_Cellular_Infiltrate"                                                                                                                                          
[33068] "Non-Invasive_Lesion"                                                                                                                                                  
[33069] "Microinvasive_Malignant_Neoplasm"                                                                                                                                     
[33070] "Necrotic_Neoplasm"                                                                                                                                                    
[33071] "Osteolytic_Neoplasm"                                                                                                                                                  
[33072] "Papillary_Neoplasm"                                                                                                                                                   
[33073] "Premalignant_Neoplasm"                                                                                                                                                
[33074] "Tubular_Neoplasm"                                                                                                                                                     
[33075] "Villous_Neoplasm"                                                                                                                                                     
[33076] "Encapsulated_Neoplasm"                                                                                                                                                
[33077] "Non-Encapsulated_Neoplasm"                                                                                                                                            
[33078] "Non-Metastatic_Neoplasm"                                                                                                                                              
[33079] "Non-Lytic_Metastatic_Lesion"                                                                                                                                          
[33080] "Grade_1_Malignant_Neoplasm"                                                                                                                                           
[33081] "Grade_2_Malignant_Neoplasm"                                                                                                                                           
[33082] "Malignant_Neoplasm_by_Grade"                                                                                                                                          
[33083] "Grade_3_Malignant_Neoplasm"                                                                                                                                           
[33084] "Grade_3a_Malignant_Neoplasm"                                                                                                                                          
[33085] "Grade_3b_Malignant_Neoplasm"                                                                                                                                          
[33086] "Grade_4_Malignant_Neoplasm"                                                                                                                                           
[33087] "High_Grade_Malignant_Neoplasm"                                                                                                                                        
[33088] "Intermediate_Grade_Malignant_Neoplasm"                                                                                                                                
[33089] "Low_Grade_Malignant_Neoplasm"                                                                                                                                         
[33090] "Moderately_Differentiated_Malignant_Neoplasm"                                                                                                                         
[33091] "Poorly_Differentiated_Malignant_Neoplasm"                                                                                                                             
[33092] "Undifferentiated_Malignant_Neoplasm"                                                                                                                                  
[33093] "Well_Differentiated_Malignant_Neoplasm"                                                                                                                               
[33094] "Epithelial_Predominant_Pulmonary_Blastoma"                                                                                                                            
[33095] "Biphasic_Pulmonary_Blastoma"                                                                                                                                          
[33096] "Acute_Promyelocytic_Leukemia_with_Variant_Translocations"                                                                                                             
[33097] "Acute_Promyelocytic_Leukemia_with_t_11_17_q23_q21"                                                                                                                    
[33098] "Acute_Promyelocytic_Leukemia_with_t_5_17_q32_q12"                                                                                                                     
[33099] "Acute_Promyelocytic_Leukemia_with_t_11_17_q13_q21"                                                                                                                    
[33100] "Granuloma-Like_Growth_Pattern"                                                                                                                                        
[33101] "Chronic_Myelomonocytic_Leukemia_with_Eosinophilia"                                                                                                                    
[33102] "Chronic_Myelomonocytic_Leukemia-1"                                                                                                                                    
[33103] "Chronic_Myelomonocytic_Leukemia-2"                                                                                                                                    
[33104] "Hemorrhagic_Ascites"                                                                                                                                                  
[33105] "Vaginal_Stricture"                                                                                                                                                    
[33106] "Superior_Vena_Cava_Occlusion"                                                                                                                                         
[33107] "Orbivirus_Infection"                                                                                                                                                  
[33108] "Clostridium_Colitis"                                                                                                                                                  
[33109] "Posteroinferior_Myocardial_Infarction"                                                                                                                                
[33110] "Dental_and_Periodontal_Infection"                                                                                                                                     
[33111] "Abdominal_and_Gastrointestinal_Infection"                                                                                                                             
[33112] "Chronic_Polyneuropathy"                                                                                                                                               
[33113] "Abnormal_Phenolsulfonphthalein_Test"                                                                                                                                  
[33114] "Apical_Myocardial_Infarction"                                                                                                                                         
[33115] "Metastatic_Peripheral_Primitive_Neuroectodermal_Tumor_of_Bone"                                                                                                        
[33116] "Rosai-Dorfman_Disease"                                                                                                                                                
[33117] "Malignant_Reproductive_System_Neoplasm"                                                                                                                               
[33118] "Hilar_Cholangiocarcinoma"                                                                                                                                             
[33119] "Sideroblastic_Anemia"                                                                                                                                                 
[33120] "Subungual_Glomus_Tumor"                                                                                                                                               
[33121] "Diffuse_Large_B-Cell_Lymphoma_with_a_Germinal_Center_B-Cell_Expression_Profile"                                                                                       
[33122] "Diffuse_Large_B-Cell_Lymphoma_with_an_Activated_B-Cell_Expression_Profile"                                                                                            
[33123] "Metastatic_Carcinoma_to_the_Bone"                                                                                                                                     
[33124] "Intraductal_Breast_Neoplasm"                                                                                                                                          
[33125] "Invasive_Micropapillary_Breast_Carcinoma"                                                                                                                             
[33126] "Invasive_Papillary_Breast_Carcinoma"                                                                                                                                  
[33127] "Flat_Ductal_Epithelial_Atypia_of_the_Breast"                                                                                                                          
[33128] "Central_Papilloma"                                                                                                                                                    
[33129] "Peripheral_Papilloma"                                                                                                                                                 
[33130] "Atypical_Breast_Papilloma"                                                                                                                                            
[33131] "Intraductal_Papillary_Breast_Neoplasm"                                                                                                                                
[33132] "Crystal_of_Reinke_Formation"                                                                                                                                          
[33133] "Testicular_Dermoid_Cyst"                                                                                                                                              
[33134] "Endometrial_Mucinous_Adenocarcinoma"                                                                                                                                  
[33135] "Early_Invasive_Cervical_Squamous_Cell_Carcinoma"                                                                                                                      
[33136] "Cervical_Mucinous_Adenocarcinoma"                                                                                                                                     
[33137] "Early_Invasive_Cervical_Adenocarcinoma"                                                                                                                               
[33138] "Cervical_Malignant_Mixed_Mesodermal_Mullerian_Tumor"                                                                                                                  
[33139] "Childhood_Botryoid-Type_Embryonal_Rhabdomyosarcoma_of_the_Vulva"                                                                                                      
[33140] "Adult_Botryoid-Type_Embryonal_Rhabdomyosarcoma"                                                                                                                       
[33141] "BRCA_1_Syndrome"                                                                                                                                                      
[33142] "BRCA_2_Syndrome"                                                                                                                                                      
[33143] "Hereditary_Ovarian_Carcinoma"                                                                                                                                         
[33144] "Rapidly_Enlarging_Mass"                                                                                                                                               
[33145] "Aggressive_Clinical_Course"                                                                                                                                           
[33146] "Indolent_Clinical_Course"                                                                                                                                             
[33147] "Hereditary_Male_Breast_Carcinoma"                                                                                                                                     
[33148] "Hereditary_Female_Breast_Carcinoma"                                                                                                                                   
[33149] "Encapsulated_Mass"                                                                                                                                                    
[33150] "Superficial_Lesion"                                                                                                                                                   
[33151] "Non-Measurable_Lesion"                                                                                                                                                
[33152] "Non-Metastatic_Mass"                                                                                                                                                  
[33153] "Metastatic_Mass"                                                                                                                                                      
[33154] "Anaplastic_Lesion"                                                                                                                                                    
[33155] "Non-Melanomatous_Lesion"                                                                                                                                              
[33156] "Malignant_Cellular_Infiltrate"                                                                                                                                        
[33157] "Borderline_Lesion"                                                                                                                                                    
[33158] "Invasive_Lesion"                                                                                                                                                      
[33159] "In_Situ_Lesion"                                                                                                                                                       
[33160] "Mucinous_Lesion"                                                                                                                                                      
[33161] "Serous_Lesion"                                                                                                                                                        
[33162] "Villous_Pattern"                                                                                                                                                      
[33163] "Benign_Cellular_Infiltrate"                                                                                                                                           
[33164] "Necrotic_Lesion"                                                                                                                                                      
[33165] "Microinvasive_Lesion"                                                                                                                                                 
[33166] "Non-Malignant_Cellular_Infiltrate"                                                                                                                                    
[33167] "Premalignant_Change"                                                                                                                                                  
[33168] "Non-Seminomatous_Lesion"                                                                                                                                              
[33169] "Comedo_Change"                                                                                                                                                        
[33170] "High_Grade_Lesion"                                                                                                                                                    
[33171] "Low_Grade_Lesion"                                                                                                                                                     
[33172] "Moderately_Differentiated_Lesion"                                                                                                                                     
[33173] "Poorly_Differentiated_Lesion"                                                                                                                                         
[33174] "Well_Differentiated_Lesion"                                                                                                                                           
[33175] "Undifferentiated_Lesion"                                                                                                                                              
[33176] "Grade_1_Lesion"                                                                                                                                                       
[33177] "Grade_2_Lesion"                                                                                                                                                       
[33178] "Grade_3_Lesion"                                                                                                                                                       
[33179] "Grade_3a_Lesion"                                                                                                                                                      
[33180] "Grade_3b_Lesion"                                                                                                                                                      
[33181] "Grade_4_Lesion"                                                                                                                                                       
[33182] "Intermediate_Grade_Lesion"                                                                                                                                            
[33183] "Stage_I_Lesion"                                                                                                                                                       
[33184] "Stage_II_Lesion"                                                                                                                                                      
[33185] "Stage_III_Lesion"                                                                                                                                                     
[33186] "Stage_IV_Lesion"                                                                                                                                                      
[33187] "Stage_A_Lesion"                                                                                                                                                       
[33188] "Stage_B_Lesion"                                                                                                                                                       
[33189] "Stage_C_Lesion"                                                                                                                                                       
[33190] "Stage_D_Lesion"                                                                                                                                                       
[33191] "Extensive_Stage_Lesion"                                                                                                                                               
[33192] "Limited_Stage_Lesion"                                                                                                                                                 
[33193] "Unspecified_Stage_Lesion"                                                                                                                                             
[33194] "Stage_Is_Lesion"                                                                                                                                                      
[33195] "Chronic_Phase_of_Disease"                                                                                                                                             
[33196] "Accelerated_Phase_of_Disease"                                                                                                                                         
[33197] "Favorable_Clinical_Outcome"                                                                                                                                           
[33198] "Acute_Clinical_Course"                                                                                                                                                
[33199] "Chronic_Clinical_Course"                                                                                                                                              
[33200] "Progressive_Clinical_Course"                                                                                                                                          
[33201] "Newly_Diagnosed_Disease"                                                                                                                                              
[33202] "Localized_Disease"                                                                                                                                                    
[33203] "Metastatic_Recurrent_Disease"                                                                                                                                         
[33204] "Metasynchronous_Lesion"                                                                                                                                               
[33205] "Unresectable_Mass"                                                                                                                                                    
[33206] "Resectable_Mass"                                                                                                                                                      
[33207] "Resected_Mass"                                                                                                                                                        
[33208] "Hormone_Responsive_Mass"                                                                                                                                              
[33209] "Hemorrhagic_Fever"                                                                                                                                                    
[33210] "Viral_Hemorrhagic_Fever"                                                                                                                                              
[33211] "Ebola_Hemorrhagic_Fever"                                                                                                                                              
[33212] "Sweating"                                                                                                                                                             
[33213] "Prolapse"                                                                                                                                                             
[33214] "Negative_Lymph_Node"                                                                                                                                                  
[33215] "Stellate_Configuration"                                                                                                                                               
[33216] "Bilateral_Mass"                                                                                                                                                       
[33217] "Single-File_Linear_Pattern"                                                                                                                                           
[33218] "Fibrotic_Stroma_Formation"                                                                                                                                            
[33219] "Paget_Involvement"                                                                                                                                                    
[33220] "Multifocal_Lesion"                                                                                                                                                    
[33221] "Micropapillary_Pattern"                                                                                                                                               
[33222] "Solid_Pattern"                                                                                                                                                        
[33223] "Firm_Mass"                                                                                                                                                            
[33224] "Necrotic_Change"                                                                                                                                                      
[33225] "Fatty_Change"                                                                                                                                                         
[33226] "Globular_Hyaline_Body"                                                                                                                                                
[33227] "Thorotrast_Exposure"                                                                                                                                                  
[33228] "Multinodular_Mass"                                                                                                                                                    
[33229] "Fetal_Epithelial_Differentiation"                                                                                                                                     
[33230] "Mesenchymal_Differentiation"                                                                                                                                          
[33231] "Neurosecretory_Granule"                                                                                                                                               
[33232] "Arteriovenous_Fistula"                                                                                                                                                
[33233] "Bilateral_Deafness"                                                                                                                                                   
[33234] "Complete_Deafness"                                                                                                                                                    
[33235] "Skin_Granuloma"                                                                                                                                                       
[33236] "Vena_Cava_Occlusion"                                                                                                                                                  
[33237] "Mycobacterium_Avium_Infection"                                                                                                                                        
[33238] "Astler-Coller_C2_Colon_Carcinoma"                                                                                                                                     
[33239] "Astler-Coller_C1_Colon_Carcinoma"                                                                                                                                     
[33240] "Astler-Coller_B2_Rectal_Carcinoma"                                                                                                                                    
[33241] "Astler-Coller_B2_Colorectal_Carcinoma"                                                                                                                                
[33242] "Astler-Coller_A_Colon_Carcinoma"                                                                                                                                      
[33243] "Astler-Coller_B1_Rectal_Carcinoma"                                                                                                                                    
[33244] "Astler-Coller_B1_Colorectal_Carcinoma"                                                                                                                                
[33245] "Peutz-Jeghers_Polyp_of_the_Stomach"                                                                                                                                   
[33246] "Small_Intestinal_Polyp"                                                                                                                                               
[33247] "Gastrointestinal_Adenoma"                                                                                                                                             
[33248] "Myeloblasts_Under_2_Percent_of_Peripheral_Blood_White_Cells"                                                                                                          
[33249] "Myeloblasts_Under_5_Percent_of_Bone_Marrow_Nucleated_Cells"                                                                                                           
[33250] "Myeloblasts_10-19_Percent_of_Bone_Marrow_Nucleated_Cells"                                                                                                             
[33251] "Myeloblasts_10-19_Percent_of_Peripheral_Blood_White_Cells"                                                                                                            
[33252] "Bone_Marrow_Fibrosis"                                                                                                                                                 
[33253] "Blasts_20_Percent_or_More_of_Peripheral_Blood_White_Cells"                                                                                                            
[33254] "Blasts_20_Percent_or_More_of_Bone_Marrow_Nucleated_Cells"                                                                                                             
[33255] "Immature_Granulocytes_in_Peripheral_Blood_Increased"                                                                                                                  
[33256] "Myeloblasts_Under_20_Percent_of_Bone_Marrow_Nucleated_Cells"                                                                                                          
[33257] "Normoblastic_Erythroid_Hyperplasia"                                                                                                                                   
[33258] "Leukoerythroblastosis"                                                                                                                                                
[33259] "Myeloblasts_Under_10_Percent_of_Bone_Marrow_Nucleated_Cells"                                                                                                          
[33260] "Blasts_Under_20_Percent_of_Peripheral_Blood_White_Cells"                                                                                                              
[33261] "Myeloblasts_Under_5_Percent_of_Peripheral_Blood_White_Cells"                                                                                                          
[33262] "Myeloblasts_5-19_Percent_of_Peripheral_Blood_White_Cells"                                                                                                             
[33263] "Myeloblasts_Under_20_Percent_of_Peripheral_Blood_White_Cells"                                                                                                         
[33264] "Hemoglobin_F_Increased"                                                                                                                                               
[33265] "Ringed_Sideroblasts_Under_15_Percent_of_Erythroid_Precursors"                                                                                                         
[33266] "Ringed_Sideroblasts_15_Percent_or_More_of_Erythroid_Precursors"                                                                                                       
[33267] "Bi-Cytopenia"                                                                                                                                                         
[33268] "Myeloblasts_Under_1_Percent_of_Peripheral_Blood_White_Cells"                                                                                                          
[33269] "Myeloblasts_5-19_Percent_of_Bone_Marrow_Nucleated_Cells"                                                                                                              
[33270] "Myeloblasts_5-9_Percent_of_Bone_Marrow_Nucleated_Cells"                                                                                                               
[33271] "Myeloblasts_20_Percent_or_More_of_Bone_Marrow_Nucleated_Cells"                                                                                                        
[33272] "Myeloblasts_20_Percent_or_More_of_Peripheral_Blood_White_Cells"                                                                                                       
[33273] "Bone_Marrow_Eosinophilia"                                                                                                                                             
[33274] "Peripheral_Blood_Eosinophilia"                                                                                                                                        
[33275] "Bone_Marrow_Dysplasia_Present"                                                                                                                                        
[33276] "Bone_Marrow_Dysplasia_Present_in_50_Percent_or_More_of_the_Cells_of_Two_Cell_Lines"                                                                                   
[33277] "Bone_Marrow_Dysplasia_Present_in_10_Percent_or_More_of_the_Cells_of_Two_Cell_Lines"                                                                                   
[33278] "Promyelocytes_Myelocytes_and_Mature_Neutrophils_10_Percent_or_More_of_Bone_Marrow_Cells"                                                                              
[33279] "Neoplastic_Monocytes_and_Precursors_20_Percent_or_More_of_Bone_Marrow_Cells"                                                                                          
[33280] "Monoblasts_20_Percent_or_More_of_Bone_Marrow_Nucleated_Cells"                                                                                                         
[33281] "Monoblasts_80_Percent_or_More_of_Bone_Marrow_Nucleated_Cells"                                                                                                         
[33282] "Neoplastic_Promonocytes_in_Bone_Marrow_Markedly_Increased"                                                                                                            
[33283] "Erythroid_Precursors_50_Percent_or_More_of_Bone_Marrow_Nucleated_Cells"                                                                                               
[33284] "Myeloblasts_20_Percent_or_More_of_Bone_Marrow_Non-Erythroid_Cells"                                                                                                    
[33285] "Erythroid_Precursors_80_Percent_or_More_of_Bone_Marrow_Nucleated_Cells"                                                                                               
[33286] "Megakaryoblasts_50_Percent_or_More_of_Bone_Marrow_Nucleated_Cells"                                                                                                    
[33287] "Normal_Bone_Marrow_Test_Results"                                                                                                                                      
[33288] "Atypical_Lymphocytes_Present_in_Bone_Marrow"                                                                                                                          
[33289] "Atypical_Lymphocytes_Present_in_Peripheral_Blood"                                                                                                                     
[33290] "Auer_Rods_Present"                                                                                                                                                    
[33291] "Benzene_Exposure"                                                                                                                                                     
[33292] "Ineffective_Hematopoiesis_Present"                                                                                                                                    
[33293] "Bone_Marrow_Basophilia"                                                                                                                                               
[33294] "Peripheral_Blood_Basophilia"                                                                                                                                          
[33295] "Secondary_Neoplasm"                                                                                                                                                   
[33296] "Hematogenous_Spread"                                                                                                                                                  
[33297] "Intravascular_Spread"                                                                                                                                                 
[33298] "Lymphatic_Spread"                                                                                                                                                     
[33299] "Acute_Promyelocytic_Leukemia_with_t_15_17_q22_q12_PML_RARa"                                                                                                           
[33300] "Hereditary_Conventional_Clear_Cell_Renal_Cell_Carcinoma"                                                                                                              
[33301] "Non-Hereditary_Conventional_Clear_Cell_Renal_Cell_Carcinoma"                                                                                                          
[33302] "Oral_Cavity_Leukoplakia"                                                                                                                                              
[33303] "Metastatic_Malignant_Neoplasm"                                                                                                                                        
[33304] "Metastatic_Benign_Neoplasm"                                                                                                                                           
[33305] "Acute_Adult_T-Cell_Lymphoma_Leukemia"                                                                                                                                 
[33306] "Lymphomatous_Adult_T-Cell_Lymphoma_Leukemia"                                                                                                                          
[33307] "Hodgkin_s-Like_Adult_T-Cell_Lymphoma_Leukemia"                                                                                                                        
[33308] "T-Cell_Prolymphocytic_Leukemia_Small_Cell_Variant"                                                                                                                    
[33309] "T-Cell_Prolymphocytic_Leukemia_Cerebriform_Cell_Variant"                                                                                                              
[33310] "Chronic_Lymphocytic_Leukemia_with_Plasmacytoid_Differentiation"                                                                                                       
[33311] "Small_Lymphocytic_Lymphoma_with_Plasmacytoid_Differentiation"                                                                                                         
[33312] "Splenic_Marginal_Zone_B-Cell_Lymphoma_without_Villous_Lymphocytes"                                                                                                    
[33313] "Polyclonal_Polymorphic_Post-Transplant_Lymphoproliferative_Disorder"                                                                                                  
[33314] "Monoclonal_Polymorphic_Post-Transplant_Lymphoproliferative_Disorder"                                                                                                  
[33315] "Finding_by_Site_or_System"                                                                                                                                            
[33316] "Gastrointestinal_System_Finding"                                                                                                                                      
[33317] "Nervous_System_Finding"                                                                                                                                               
[33318] "Integumentary_System_Finding"                                                                                                                                         
[33319] "Head_and_Neck_Finding"                                                                                                                                                
[33320] "Eye_and_Ear_Finding"                                                                                                                                                  
[33321] "Reproductive_System_Finding"                                                                                                                                          
[33322] "Endocrine_System_Finding"                                                                                                                                             
[33323] "Urinary_Tract_Finding"                                                                                                                                                
[33324] "Congenital_or_Acquired_Anatomic_Abnormality"                                                                                                                          
[33325] "Connective_and_Soft_Tissue_Finding"                                                                                                                                   
[33326] "Hematopoietic_System_Finding"                                                                                                                                         
[33327] "Chemical_Exposure"                                                                                                                                                    
[33328] "Finding_by_Cause"                                                                                                                                                     
[33329] "Test_Result"                                                                                                                                                          
[33330] "Ovalocytosis"                                                                                                                                                         
[33331] "Neoplastic_Growth_or_Spread"                                                                                                                                          
[33332] "Other_Finding"                                                                                                                                                        
[33333] "Regional_Cancer"                                                                                                                                                      
[33334] "Regional_Lymph_Node_Involvement"                                                                                                                                      
[33335] "Lesion_by_Grade"                                                                                                                                                      
[33336] "Lesion_by_Stage"                                                                                                                                                      
[33337] "Breast_Carcinoma_Metastatic_to_the_Lung"                                                                                                                              
[33338] "Breast_Carcinoma_Metastatic_to_the_Brain"                                                                                                                             
[33339] "Breast_Carcinoma_Metastatic_to_the_Liver"                                                                                                                             
[33340] "Breast_Carcinoma_Metastatic_to_the_Bone"                                                                                                                              
[33341] "Lung_Carcinoma_Metastatic_to_the_Brain"                                                                                                                               
[33342] "Lung_Carcinoma_Metastatic_to_the_Bone"                                                                                                                                
[33343] "Lung_Carcinoma_Metastatic_to_the_Liver"                                                                                                                               
[33344] "Prostate_Carcinoma_Metastatic_to_the_Lung"                                                                                                                            
[33345] "Prostate_Carcinoma_Metastatic_to_the_Bone"                                                                                                                            
[33346] "Colon_Carcinoma_Metastatic_to_the_Liver"                                                                                                                              
[33347] "Secondary_Carcinoma"                                                                                                                                                  
[33348] "Intestinal_Metaplasia_of_Esophageal_Mucosa"                                                                                                                           
[33349] "Philadelphia_Positive_Acute_Lymphoblastic_Leukemia"                                                                                                                   
[33350] "Chromosomal_Loss"                                                                                                                                                     
[33351] "t_11_22_q24_q12"                                                                                                                                                      
[33352] "t_12_16_q13_p11"                                                                                                                                                      
[33353] "Microsatellite_Instability"                                                                                                                                           
[33354] "t_8_14_q24_q32"                                                                                                                                                       
[33355] "t_8_22_q24_q11"                                                                                                                                                       
[33356] "Gene_Abnormality"                                                                                                                                                     
[33357] "RB_1Tumor-Suppressor_Gene_Inactivation"                                                                                                                               
[33358] "TP53_Tumor-Suppressor_Gene_Inactivation"                                                                                                                              
[33359] "TGFbetaRII_Tumor-Suppressor_Gene_Inactivation"                                                                                                                        
[33360] "Polysomy"                                                                                                                                                             
[33361] "Clonal_Gene_Rearrangement"                                                                                                                                            
[33362] "Tumor-Suppressor_Gene_Inactivation"                                                                                                                                   
[33363] "Abnormal_DNA_Repair"                                                                                                                                                  
[33364] "Deregulation_of_Protein_and_Messenger_RNA_Expression"                                                                                                                 
[33365] "Messenger_RNA_Overexpression"                                                                                                                                         
[33366] "Deregulation_of_Apoptosis"                                                                                                                                            
[33367] "Cell_Cycle_Deregulation"                                                                                                                                              
[33368] "Molecular_Pathway_Deregulation"                                                                                                                                       
[33369] "Signal_Transduction_Pathway_Deregulation"                                                                                                                             
[33370] "Microsatellite_Mutation_Pathway_Deregulation"                                                                                                                         
[33371] "Tumor-Suppressor_Pathway_Deregulation"                                                                                                                                
[33372] "Oncogene_Deregulation"                                                                                                                                                
[33373] "Protein_Deregulation"                                                                                                                                                 
[33374] "Fusion_Protein_Expression"                                                                                                                                            
[33375] "t_8_14_q24_q11"                                                                                                                                                       
[33376] "t_1_14_p32_q11"                                                                                                                                                       
[33377] "t_7_9_q34_q34_3"                                                                                                                                                      
[33378] "t_11_14_p15_q11"                                                                                                                                                      
[33379] "t_11_14_p13_q11"                                                                                                                                                      
[33380] "t_10_14_q24_q11"                                                                                                                                                      
[33381] "t_7_10_q34_q24"                                                                                                                                                       
[33382] "t_3_14_q27_q32"                                                                                                                                                       
[33383] "t_3_4_q27_p11"                                                                                                                                                        
[33384] "t_14_14_q11_q32"                                                                                                                                                      
[33385] "t_14_19_q32_q13_1"                                                                                                                                                    
[33386] "t_5_14_q31_q32"                                                                                                                                                       
[33387] "t_1_7_p33_q35"                                                                                                                                                        
[33388] "t_X_14_q28_11"                                                                                                                                                        
[33389] "t_17_19_q22_p13"                                                                                                                                                      
[33390] "t_5_17_q32_q12"                                                                                                                                                       
[33391] "t_11_17_q23_q21"                                                                                                                                                      
[33392] "t_11_17_q13_q21"                                                                                                                                                      
[33393] "t_4_11_q21_q23"                                                                                                                                                       
[33394] "t_9_11_q21_q23"                                                                                                                                                       
[33395] "t_21_22_q22_q12"                                                                                                                                                      
[33396] "t_7_22_p22_q12"                                                                                                                                                       
[33397] "t_17_22_q21_q12"                                                                                                                                                      
[33398] "t_9_11_p22_q23"                                                                                                                                                       
[33399] "t_11_19_q23_p13_1"                                                                                                                                                    
[33400] "t_11_19_q23_p13_3"                                                                                                                                                    
[33401] "inv_16_p13_q22"                                                                                                                                                       
[33402] "t_12_22_q13_q12"                                                                                                                                                      
[33403] "t_11_22_p13_q12"                                                                                                                                                      
[33404] "t_1_13_q36_q14"                                                                                                                                                       
[33405] "t_3_12_q27-28_q13-15"                                                                                                                                                 
[33406] "t_1_12_p36_q13-15"                                                                                                                                                    
[33407] "t_1_12_p32-34_q13-15"                                                                                                                                                 
[33408] "t_2_12_p22-24_q13-15"                                                                                                                                                 
[33409] "t_2_12_q35-37_q13-15"                                                                                                                                                 
[33410] "t_5_12_q33_q13-15"                                                                                                                                                    
[33411] "Monosomy_13"                                                                                                                                                          
[33412] "Monosomy_16"                                                                                                                                                          
[33413] "Giant_Rod_Chromosome"                                                                                                                                                 
[33414] "Aberrant_Chromosome_1"                                                                                                                                                
[33415] "t_12_15_p13_q26"                                                                                                                                                      
[33416] "t_1_2_p11_q35-36"                                                                                                                                                     
[33417] "t_2_13_q35_q14"                                                                                                                                                       
[33418] "t_X_18_p11_q11"                                                                                                                                                       
[33419] "Molecular_Genetic_Abnormality"                                                                                                                                        
[33420] "t_X_17_p11_q25"                                                                                                                                                       
[33421] "t_9_17_q22_q11"                                                                                                                                                       
[33422] "t_9_15_q22_q21"                                                                                                                                                       
[33423] "Trisomy_8"                                                                                                                                                            
[33424] "Trisomy_20"                                                                                                                                                           
[33425] "inv_22"                                                                                                                                                               
[33426] "t_5_12_q33_p13"                                                                                                                                                       
[33427] "t_8_13_p11_q11"                                                                                                                                                       
[33428] "t_8_9_p11_q32-34"                                                                                                                                                     
[33429] "t_6_8_q27_p11"                                                                                                                                                        
[33430] "Loss_of_Chromosome_20q"                                                                                                                                               
[33431] "t_3_3_q21_q26_2"                                                                                                                                                      
[33432] "inv_3_q21q26_2"                                                                                                                                                       
[33433] "Loss_of_Chromosome_7q"                                                                                                                                                
[33434] "t_5_12_q31_p12"                                                                                                                                                       
[33435] "Loss_of_Chromosome_12p"                                                                                                                                               
[33436] "Monosomy_7"                                                                                                                                                           
[33437] "ins_3_3"                                                                                                                                                              
[33438] "t_3_5_q25_q34"                                                                                                                                                        
[33439] "t_8_16_p11_p13"                                                                                                                                                       
[33440] "t_1_22_p13_q13"                                                                                                                                                       
[33441] "Trisomy_12"                                                                                                                                                           
[33442] "del_13q14"                                                                                                                                                            
[33443] "del_11q22q23"                                                                                                                                                         
[33444] "del_6q21"                                                                                                                                                             
[33445] "del_17p13"                                                                                                                                                            
[33446] "Trisomy_3"                                                                                                                                                            
[33447] "inv_14"                                                                                                                                                               
[33448] "t_8_8_p11-12_q12"                                                                                                                                                     
[33449] "Trisomy_8q"                                                                                                                                                           
[33450] "del_12p13"                                                                                                                                                            
[33451] "CD95_Apoptotic_Pathway_Deregulation"                                                                                                                                  
[33452] "Apoptotic_Pathway_Deregulation"                                                                                                                                       
[33453] "i_7q"                                                                                                                                                                 
[33454] "Trisomy_5"                                                                                                                                                            
[33455] "Additional_X_Chromosome"                                                                                                                                              
[33456] "t_1_2_q25_p23"                                                                                                                                                        
[33457] "t_2_3_p23_q21"                                                                                                                                                        
[33458] "inv_2_p23q35"                                                                                                                                                         
[33459] "Chromosomal_Gain"                                                                                                                                                     
[33460] "Gain_of_Chromosome_2p"                                                                                                                                                
[33461] "Gain_of_Chromosome_9p"                                                                                                                                                
[33462] "Gain_of_Chromosome_12q"                                                                                                                                               
[33463] "Clonal_BCL-2_Gene_Rearrangement"                                                                                                                                      
[33464] "Clonal_Immunoglobulin_Gene_Rearrangement"                                                                                                                             
[33465] "Clonal_Immunoglobulin_Heavy_Chain_Gene_Rearrangement"                                                                                                                 
[33466] "Clonal_Immunoglobulin_Light_Chain_Gene_Rearrangement"                                                                                                                 
[33467] "Clonal_T-Cell_Receptor_Gene_Rearrangement"                                                                                                                            
[33468] "Clonal_T-Cell_Receptor_Beta_Chain_Gene_Rearrangement"                                                                                                                 
[33469] "Clonal_T-Cell_Receptor_Gamma_Chain_Gene_Rearrangement"                                                                                                                
[33470] "Clonal_BCL-6_Gene_Rearrangement"                                                                                                                                      
[33471] "Clonal_Antigen_Receptor_Gene_Rearrangement"                                                                                                                           
[33472] "Clonal_Immunoglobulin_Kappa_Light_Chain_Gene_Rearrangement"                                                                                                           
[33473] "Clonal_Immunoglobulin_Lambda_Light_Chain_Gene_Rearrangement"                                                                                                          
[33474] "Gain_of_Chromosome_7q"                                                                                                                                                
[33475] "Gain_of_Chromosome_7"                                                                                                                                                 
[33476] "Gain_of_Chromosome_8"                                                                                                                                                 
[33477] "Gain_of_Chromosome_19"                                                                                                                                                
[33478] "Gain_of_Chromosome_22"                                                                                                                                                
[33479] "Gain_of_Chromosome_3"                                                                                                                                                 
[33480] "Monosomy_22"                                                                                                                                                          
[33481] "Gain_of_Chromosome_9"                                                                                                                                                 
[33482] "Gain_of_Chromosome_12"                                                                                                                                                
[33483] "Gain_of_Chromosome_15"                                                                                                                                                
[33484] "Gain_of_Chromosome_17"                                                                                                                                                
[33485] "Gain_of_Chromosome_18"                                                                                                                                                
[33486] "Monosomy_10"                                                                                                                                                          
[33487] "Monosomy_21"                                                                                                                                                          
[33488] "del_6q25"                                                                                                                                                             
[33489] "del_14q21"                                                                                                                                                            
[33490] "del_19p12"                                                                                                                                                            
[33491] "der_15_21_q10_q10"                                                                                                                                                    
[33492] "Ring_Chromosome_1"                                                                                                                                                    
[33493] "Trisomy_6"                                                                                                                                                            
[33494] "Trisomy_7"                                                                                                                                                            
[33495] "i_17q"                                                                                                                                                                
[33496] "Unbalanced_Translocation_of_Chromosome_1"                                                                                                                             
[33497] "Gain_of_Chromosome_20q"                                                                                                                                               
[33498] "Gain_of_Chromosome_15q"                                                                                                                                               
[33499] "Gain_of_Chromosome_1q"                                                                                                                                                
[33500] "Gain_of_Chromosome_9q"                                                                                                                                                
[33501] "Gain_of_Chromosome_17q"                                                                                                                                               
[33502] "Cyclin_D1_Protein_Overexpression"                                                                                                                                     
[33503] "Gain_of_Chromosome_5"                                                                                                                                                 
[33504] "Gain_of_Chromosome_3q"                                                                                                                                                
[33505] "Gain_of_Chromosome_8q"                                                                                                                                                
[33506] "Gain_of_Chromosome_5p"                                                                                                                                                
[33507] "Loss_of_Chromosome_14"                                                                                                                                                
[33508] "Loss_of_Chromosome_22"                                                                                                                                                
[33509] "High-Frequency_Microsatellite_Instability"                                                                                                                            
[33510] "Low-Frequency_Microsatellite_Instability"                                                                                                                             
[33511] "Trisomy_2"                                                                                                                                                            
[33512] "Loss_of_Chromosome_18q"                                                                                                                                               
[33513] "Loss_of_Chromosome_13q"                                                                                                                                               
[33514] "Loss_of_Chromosome_12q"                                                                                                                                               
[33515] "Loss_of_Chromosome_17p"                                                                                                                                               
[33516] "Loss_of_Chromosome_6p"                                                                                                                                                
[33517] "Loss_of_Chromosome_1p"                                                                                                                                                
[33518] "Loss_of_Chromosome_3p"                                                                                                                                                
[33519] "Loss_of_Chromosome_8p"                                                                                                                                                
[33520] "Loss_of_Chromosome_6"                                                                                                                                                 
[33521] "Loss_of_Chromosome_11p"                                                                                                                                               
[33522] "Loss_of_Chromosome_22q"                                                                                                                                               
[33523] "Loss_of_Chromosome_19q"                                                                                                                                               
[33524] "Monosomy_9"                                                                                                                                                           
[33525] "Monosomy_17"                                                                                                                                                          
[33526] "del_10q23"                                                                                                                                                            
[33527] "Loss_of_Chromosome_10p"                                                                                                                                               
[33528] "del_10q25-26"                                                                                                                                                         
[33529] "del_5q22"                                                                                                                                                             
[33530] "Loss_of_Chromosome_16q"                                                                                                                                               
[33531] "Loss_of_Chromosome_10q"                                                                                                                                               
[33532] "t_11_v_q23_v"                                                                                                                                                         
[33533] "t_7_19_q34_q13"                                                                                                                                                       
[33534] "t_7_14_q35_q32_1"                                                                                                                                                     
[33535] "t_17_22_q22_q13"                                                                                                                                                      
[33536] "Partial_Trisomy_1q"                                                                                                                                                   
[33537] "Gain_of_Chromosome_13"                                                                                                                                                
[33538] "Monosomy_5"                                                                                                                                                           
[33539] "Loss_of_Chromosome_7"                                                                                                                                                 
[33540] "Gain_of_Chromosome_11"                                                                                                                                                
[33541] "Loss_of_Chromosome_5"                                                                                                                                                 
[33542] "Gain_of_Chromosome_21"                                                                                                                                                
[33543] "t_3_21_q21_q26"                                                                                                                                                       
[33544] "Trisomy_13"                                                                                                                                                           
[33545] "Trisomy_4"                                                                                                                                                            
[33546] "del_12p11p13"                                                                                                                                                         
[33547] "t_6_9_p23_q34"                                                                                                                                                        
[33548] "del_11q23"                                                                                                                                                            
[33549] "del_7q21-32"                                                                                                                                                          
[33550] "Loss_of_Chromosome_8"                                                                                                                                                 
[33551] "Loss_of_Chromosome_13"                                                                                                                                                
[33552] "Loss_of_Chromosome_X"                                                                                                                                                 
[33553] "del_6q23"                                                                                                                                                             
[33554] "Gain_of_Chromosome_X"                                                                                                                                                 
[33555] "Rearrangement_of_8q11-13"                                                                                                                                             
[33556] "Chromosomal_Rearrangement"                                                                                                                                            
[33557] "Loss_of_Chromosome_16"                                                                                                                                                
[33558] "Rearrangement_of_11q13-21"                                                                                                                                            
[33559] "Loss_of_Chromosome_17q"                                                                                                                                               
[33560] "Gain_of_Chromosome_5q"                                                                                                                                                
[33561] "Rearrangement_of_1p11-13"                                                                                                                                             
[33562] "Loss_of_Chromosome_2p"                                                                                                                                                
[33563] "Loss_of_Chromosome_2q"                                                                                                                                                
[33564] "Loss_of_Chromosome_11"                                                                                                                                                
[33565] "Gain_of_Chromosome_7p"                                                                                                                                                
[33566] "Gain_of_Chromosome_7q32"                                                                                                                                              
[33567] "Gain_of_Chromosome_1p31"                                                                                                                                              
[33568] "Gain_of_Chromosome_1q21-31"                                                                                                                                           
[33569] "del_3p21-23"                                                                                                                                                          
[33570] "del_8p21-pter"                                                                                                                                                        
[33571] "del_13q12-13"                                                                                                                                                         
[33572] "del_13q32-qter"                                                                                                                                                       
[33573] "Gain_of_Chromosome_1"                                                                                                                                                 
[33574] "Gain_of_Chromosome_20"                                                                                                                                                
[33575] "del_11p15"                                                                                                                                                            
[33576] "Rearrangement_of_1p11-q11"                                                                                                                                            
[33577] "Rearrangement_of_12q13"                                                                                                                                               
[33578] "t_1_3_p36_3_q25"                                                                                                                                                      
[33579] "i_8_q10"                                                                                                                                                              
[33580] "del_8q24_1"                                                                                                                                                           
[33581] "Rearrangement_of_8q21"                                                                                                                                                
[33582] "Rearrangement_of_6q13"                                                                                                                                                
[33583] "Rearrangement_of_6q25"                                                                                                                                                
[33584] "del_1p36"                                                                                                                                                             
[33585] "del_1p13-22"                                                                                                                                                          
[33586] "Loss_of_Chromosome_4"                                                                                                                                                 
[33587] "del_5q13-31"                                                                                                                                                          
[33588] "del_6q22-qter"                                                                                                                                                        
[33589] "del_9p22-pter"                                                                                                                                                        
[33590] "del_10q24-qter"                                                                                                                                                       
[33591] "del_11p13-pter"                                                                                                                                                       
[33592] "del_11q25"                                                                                                                                                            
[33593] "del_13q21-qter"                                                                                                                                                       
[33594] "Loss_of_Chromosome_18p"                                                                                                                                               
[33595] "del_22q13"                                                                                                                                                            
[33596] "Gain_of_Chromosome_7p13-pter"                                                                                                                                         
[33597] "Gain_of_Chromosome_12q15-qter"                                                                                                                                        
[33598] "Loss_of_Chromosome_6q"                                                                                                                                                
[33599] "Loss_of_Chromosome_9"                                                                                                                                                 
[33600] "Loss_of_Chromosome_10"                                                                                                                                                
[33601] "Loss_of_Chromosome_3"                                                                                                                                                 
[33602] "Rearrangement_of_17p"                                                                                                                                                 
[33603] "t_14_18_q32_q11"                                                                                                                                                      
[33604] "t_1_2_p22_p12"                                                                                                                                                        
[33605] "t_2_17_p23_q23"                                                                                                                                                       
[33606] "t_X_2_q11-12_p23"                                                                                                                                                     
[33607] "Gain_of_Chromosome_9q34"                                                                                                                                              
[33608] "Increased_NFkappaB_Pathway_Activation"                                                                                                                                
[33609] "del_6q21q25"                                                                                                                                                          
[33610] "Loss_of_Chromosome_16p"                                                                                                                                               
[33611] "Gain_of_Chromosome_6q"                                                                                                                                                
[33612] "Loss_of_Chromosome_1"                                                                                                                                                 
[33613] "Loss_of_Chromosome_18"                                                                                                                                                
[33614] "Loss_of_Chromosome_Y"                                                                                                                                                 
[33615] "Tetrasomy_12"                                                                                                                                                         
[33616] "Tetrasomy"                                                                                                                                                            
[33617] "inv_14_q11_q32_1"                                                                                                                                                     
[33618] "t_7_9_q34_q32"                                                                                                                                                        
[33619] "del_9p21p22"                                                                                                                                                          
[33620] "i_19"                                                                                                                                                                 
[33621] "t_3_21_q26_q22"                                                                                                                                                       
[33622] "t_12_22_p13_q11"                                                                                                                                                      
[33623] "inv_11_p15q22"                                                                                                                                                        
[33624] "t_7_11_p15_p15"                                                                                                                                                       
[33625] "t_6_11_q27_q23"                                                                                                                                                       
[33626] "t_10_11_p11_q23"                                                                                                                                                      
[33627] "del_16q22"                                                                                                                                                            
[33628] "t_1_21_p36_q22"                                                                                                                                                       
[33629] "t_5_21_q13_q22"                                                                                                                                                       
[33630] "t_17_21_q11_q22"                                                                                                                                                      
[33631] "t_16_21_p11_q22"                                                                                                                                                      
[33632] "del_7q31_1"                                                                                                                                                           
[33633] "del_8p22"                                                                                                                                                             
[33634] "del_8p12p21"                                                                                                                                                          
[33635] "del_10q24q25"                                                                                                                                                         
[33636] "del_16q23-24_2"                                                                                                                                                       
[33637] "Trisomy_18"                                                                                                                                                           
[33638] "Monosomy_6"                                                                                                                                                           
[33639] "Monosomy_8"                                                                                                                                                           
[33640] "Monosomy_11"                                                                                                                                                          
[33641] "Monosomy_X"                                                                                                                                                           
[33642] "Loss_of_Chromosome_17"                                                                                                                                                
[33643] "Loss_of_Chromosome_19"                                                                                                                                                
[33644] "Gain_of_Chromosome_6p"                                                                                                                                                
[33645] "Gain_of_Chromosome_17q22-q24"                                                                                                                                         
[33646] "Gain_of_Chromosome_20q13"                                                                                                                                             
[33647] "Loss_of_Chromosome_9p"                                                                                                                                                
[33648] "Gain_of_Chromosome_19q"                                                                                                                                               
[33649] "ERBB2_Gene_Amplification"                                                                                                                                             
[33650] "c-erbB2_Protein_Overexpression"                                                                                                                                       
[33651] "c-erbB2_Messenger_RNA_Overexpression"                                                                                                                                 
[33652] "c-myc_Gene_Amplification"                                                                                                                                             
[33653] "Cyclin_D1_Messenger_RNA_Overexpression"                                                                                                                               
[33654] "Cyclin_E_Protein_Overexpression"                                                                                                                                      
[33655] "Loss_of_E-cadherin_Expression"                                                                                                                                        
[33656] "Loss_of_Chromosome_3p_FHIT_Gene_Locus"                                                                                                                                
[33657] "Loss_of_Chromosome_11q_ATM_Gene_Locus"                                                                                                                                
[33658] "i_1_q10"                                                                                                                                                              
[33659] "der_1_16_q10_p10"                                                                                                                                                     
[33660] "EGFR_Gene_Amplification"                                                                                                                                              
[33661] "FGFR1_Gene_Amplification"                                                                                                                                             
[33662] "FGFR_2_Gene_Amplification"                                                                                                                                            
[33663] "CCND1_Gene_Amplification"                                                                                                                                             
[33664] "IGF2R_Tumor-Suppressor_Gene_Inactivation"                                                                                                                             
[33665] "CDH1_Tumor-Suppressor_Gene_Inactivation"                                                                                                                              
[33666] "Polysomy_3"                                                                                                                                                           
[33667] "Polysomy_10"                                                                                                                                                          
[33668] "Polysomy_17"                                                                                                                                                          
[33669] "Gain_of_Chromosome_Xq"                                                                                                                                                
[33670] "Beta_Catenin_Gene_Mutation"                                                                                                                                           
[33671] "Monoclonal_Hepatocyte_Population"                                                                                                                                     
[33672] "Growth_Factor_Overexpression"                                                                                                                                         
[33673] "Transforming_Growth_Factor-Beta_Overexpression"                                                                                                                       
[33674] "Fibroblast_Growth_Factor_2_Overexpression"                                                                                                                            
[33675] "Aberrant_DNA_Methylation"                                                                                                                                             
[33676] "KRAS_Gene_Amplification"                                                                                                                                              
[33677] "Fibroblast_Growth_Factor_1_Overexpression"                                                                                                                            
[33678] "Loss_of_Chromosome_4q"                                                                                                                                                
[33679] "Gain_of_Chromosome_6"                                                                                                                                                 
[33680] "Gain_of_Chromosome_16"                                                                                                                                                
[33681] "Gain_of_Chromosome_10"                                                                                                                                                
[33682] "v-fos_Gene_Amplification"                                                                                                                                             
[33683] "N-myc_Gene_Amplification"                                                                                                                                             
[33684] "L-myc_Gene_Amplification"                                                                                                                                             
[33685] "c-erbB1_Gene_Amplification"                                                                                                                                           
[33686] "c-fos_Gene_Amplification"                                                                                                                                             
[33687] "HRAS_Gene_Amplification"                                                                                                                                              
[33688] "MYB_Gene_Amplification"                                                                                                                                               
[33689] "MDM2_Gene_Amplification"                                                                                                                                              
[33690] "CCNE_Gene_Amplification"                                                                                                                                              
[33691] "APC_Tumor-Suppressor_Gene_Inactivation"                                                                                                                               
[33692] "WT-1_Tumor-Suppressor_Gene_Inactivation"                                                                                                                              
[33693] "NF-1_Tumor-Suppressor_Gene_Inactivation"                                                                                                                              
[33694] "NF-2_Tumor-Suppressor_Gene_Inactivation"                                                                                                                              
[33695] "VHL_Tumor-Suppressor_Gene_Inactivation"                                                                                                                               
[33696] "BRCA1_Tumor-Suppressor_Gene_Inactivation"                                                                                                                             
[33697] "BRCA2_Tumor-Suppressor_Gene_Inactivation"                                                                                                                             
[33698] "MEN-1_Tumor-Suppressor_Gene_Inactivation"                                                                                                                             
[33699] "PTCH_Tumor-Suppressor_Gene_Inactivation"                                                                                                                              
[33700] "PTEN_Tumor-Suppressor_Gene_Inactivation"                                                                                                                              
[33701] "DPC4_Tumor-Suppressor_Gene_Inactivation"                                                                                                                              
[33702] "E-CAD_Tumor-Suppressor_Gene_Inactivation"                                                                                                                             
[33703] "LKB1_STK1_Tumor-Suppressor_Gene_Inactivation"                                                                                                                         
[33704] "TSC2_Tumor-Suppressor_Gene_Inactivation"                                                                                                                              
[33705] "hMSH2_Mismatch_Repair_Gene_Inactivation"                                                                                                                              
[33706] "hMLH1_Mismatch_Repair_Gene_Inactivation"                                                                                                                              
[33707] "Mismatch_Repair_Gene_Inactivation"                                                                                                                                    
[33708] "TGF-beta_RII_Tumor-Suppressor_Gene_Inactivation"                                                                                                                      
[33709] "hMSH6_Mismatch_Repair_Gene_Inactivation"                                                                                                                              
[33710] "PMS1_Mismatch_Repair_Gene_Inactivation"                                                                                                                               
[33711] "PMS2_Mismatch_Repair_Gene_Inactivation"                                                                                                                               
[33712] "FHIT_Tumor-Suppressor_Gene_Inactivation"                                                                                                                              
[33713] "NPM-ALK_Fusion_Protein_Expression"                                                                                                                                    
[33714] "TPM3-ALK_Fusion_Protein_Expression"                                                                                                                                   
[33715] "TFG-ALK_Fusion_Protein_Expression"                                                                                                                                    
[33716] "TFG-ALKshort_Fusion_Protein_Expression"                                                                                                                               
[33717] "TFG-ALKlong_Fusion_Protein_Expression"                                                                                                                                
[33718] "ATIC-ALK_Fusion_Protein_Expression"                                                                                                                                   
[33719] "p210_Fusion_Protein_Expression"                                                                                                                                       
[33720] "p230_Fusion_Protein_Expression"                                                                                                                                       
[33721] "p190_Fusion_Protein_Expression"                                                                                                                                       
[33722] "BCR-ABL_Fusion_Protein_Expression"                                                                                                                                    
[33723] "LE_Cell"                                                                                                                                                              
[33724] "Sickle_Cell"                                                                                                                                                          
[33725] "Sideroblast"                                                                                                                                                          
[33726] "Segmented_Neutrophil"                                                                                                                                                 
[33727] "Malignant_Neuroendocrine_Fusiform_Small_Cell"                                                                                                                         
[33728] "Pelger-Huet_Cell"                                                                                                                                                     
[33729] "Sezary_Cell"                                                                                                                                                          
[33730] "Giant_Platelet"                                                                                                                                                       
[33731] "Neutrophil_with_Pseudo_Pelger-Huet_Nucleus"                                                                                                                           
[33732] "Abnormal_Lymphocyte"                                                                                                                                                  
[33733] "Tear-Drop_Red_Blood_Cell"                                                                                                                                             
[33734] "Guacher_s_Cell"                                                                                                                                                       
[33735] "Touton_Giant_Cell"                                                                                                                                                    
[33736] "Sea-Blue_Histiocyte"                                                                                                                                                  
[33737] "Anaplastic_Cell"                                                                                                                                                      
[33738] "Cytomegalic_Cell"                                                                                                                                                     
[33739] "Downey_Cell"                                                                                                                                                          
[33740] "Lepra_Cell"                                                                                                                                                           
[33741] "Mikulicz_Cell"                                                                                                                                                        
[33742] "Physaliphorous_Cell"                                                                                                                                                  
[33743] "Pseudoxanthoma_Cell"                                                                                                                                                  
[33744] "Raji_Cell"                                                                                                                                                            
[33745] "Spider_Cell"                                                                                                                                                          
[33746] "Centrocyte"                                                                                                                                                           
[33747] "Rhabdomyoblast"                                                                                                                                                       
[33748] "Abnormal_Epithelial_Cell"                                                                                                                                             
[33749] "Dyskeratotic_Keratinocyte"                                                                                                                                            
[33750] "Acantholytic_Keratinocyte"                                                                                                                                            
[33751] "Multinucleated_Keratinocyte"                                                                                                                                          
[33752] "Neoplastic_Keratinocyte"                                                                                                                                              
[33753] "Large_Keratinocyte"                                                                                                                                                   
[33754] "Balloon_Epithelial_Cell"                                                                                                                                              
[33755] "Castration_Cell"                                                                                                                                                      
[33756] "Neoplastic_Epithelial_Cell"                                                                                                                                           
[33757] "Paget_s_Cell"                                                                                                                                                         
[33758] "Bowenoid_Cell"                                                                                                                                                        
[33759] "Neoplastic_Epithelial_Clear_Cell"                                                                                                                                     
[33760] "Neoplastic_Clear_Cell"                                                                                                                                                
[33761] "Neoplastic_Hobnail_Cell"                                                                                                                                              
[33762] "Neoplastic_Basal_Cell"                                                                                                                                                
[33763] "Neoplastic_Squamous_Cell"                                                                                                                                             
[33764] "Neoplastic_Neuroendocrine_Cell"                                                                                                                                       
[33765] "Oat_Cell"                                                                                                                                                             
[33766] "Neoplastic_Glandular_Cell"                                                                                                                                            
[33767] "Abnormal_Glandular_Cell"                                                                                                                                              
[33768] "Neoplastic_Glandular_Cell_with_Clear_Cytoplasm"                                                                                                                       
[33769] "Abnormal_Keratinocyte"                                                                                                                                                
[33770] "Abnormal_Transitional_Cell"                                                                                                                                           
[33771] "Neoplastic_Transitional_Cell"                                                                                                                                         
[33772] "Abnormal_Myoepithelial_Cell"                                                                                                                                          
[33773] "Neoplastic_Myoepithelial_Cell"                                                                                                                                        
[33774] "Malignant_Squamous_Cell"                                                                                                                                              
[33775] "Abnormal_Squamous_Cell"                                                                                                                                               
[33776] "Adenocarcinoma_Cell"                                                                                                                                                  
[33777] "Multinucleated_Malignant_Squamous_Cell"                                                                                                                               
[33778] "Malignant_Spindle_Squamous_Cell"                                                                                                                                      
[33779] "Malignant_Tadpole_Squamous_Cell"                                                                                                                                      
[33780] "Signet_Ring_Adenocarcinoma_Cell"                                                                                                                                      
[33781] "Malignant_Transitional_Cell"                                                                                                                                          
[33782] "Malignant_Epithelial_Cell"                                                                                                                                            
[33783] "Malignant_Myoepithelial_Cell"                                                                                                                                         
[33784] "Neoplastic_Cutaneous_Basal_Cell"                                                                                                                                      
[33785] "Neoplastic_Non-Cutaneous_Basal_Cell"                                                                                                                                  
[33786] "Non-Cutaneous_Malignant_Basal_Cell"                                                                                                                                   
[33787] "Malignant_Epithelial_Clear_Cell"                                                                                                                                      
[33788] "Atypical_Reparative_Cell"                                                                                                                                             
[33789] "Metaplastic_Cell"                                                                                                                                                     
[33790] "Atypical_Parabasal_Cell"                                                                                                                                              
[33791] "Giant_Epithelial_Cell"                                                                                                                                                
[33792] "Dysplastic_Squamous_Cell"                                                                                                                                             
[33793] "Non-Keratinizing_Malignant_Small_Squamous_Cell"                                                                                                                       
[33794] "Keratinizing_Malignant_Squamous_Cell"                                                                                                                                 
[33795] "Non-Keratinizing_Malignant_Squamous_Cell"                                                                                                                             
[33796] "Non-Keratinizing_Malignant_Large_Squamous_Cell"                                                                                                                       
[33797] "Dysplastic_Glandular_Cell"                                                                                                                                            
[33798] "Malignant_Epithelial_Small_Cell"                                                                                                                                      
[33799] "Well_Differentiated_Adenocarcinoma_Cell"                                                                                                                              
[33800] "Moderately_Differentiated_Adenocarcinoma_Cell"                                                                                                                        
[33801] "Poorly_Differentiated_Adenocarcinoma_Cell"                                                                                                                            
[33802] "Abnormal_Trophoblastic_Cell"                                                                                                                                          
[33803] "Abnormal_Syncytiotrophoblastic_Cell"                                                                                                                                  
[33804] "Abnormal_Cytotrophoblastic_Cell"                                                                                                                                      
[33805] "Abnormal_Intermediate_Type_Trophoblastic_Cell"                                                                                                                        
[33806] "Neoplastic_Trophoblastic_Cell"                                                                                                                                        
[33807] "Postradiation_Dysplastic_Epithelial_Cell"                                                                                                                             
[33808] "Postradiation_Dysplastic_Glandular_Cell"                                                                                                                              
[33809] "Postradiation_Dysplastic_Squamous_Cell"                                                                                                                               
[33810] "Dysplastic_Epithelial_Cell"                                                                                                                                           
[33811] "Koilocytotic_Squamous_Cell"                                                                                                                                           
[33812] "Reactive_Epithelial_Cell"                                                                                                                                             
[33813] "Reactive_Squamous_Cell"                                                                                                                                               
[33814] "Reactive_Glandular_Cell"                                                                                                                                              
[33815] "Warthin-Finkeldey_Polykaryocyte"                                                                                                                                      
[33816] "Multinucleated_Reed-Sternberg_Cell"                                                                                                                                   
[33817] "Malignant_Clear_Squamous_Cell"                                                                                                                                        
[33818] "Adenocarcinoma_Clear_Cell"                                                                                                                                            
[33819] "Metaplastic_Epithelial_Cell"                                                                                                                                          
[33820] "Metaplastic_Squamous_Cell"                                                                                                                                            
[33821] "Large_Osteoclastic_Giant_Cell"                                                                                                                                        
[33822] "Neoplastic_Multinucleated_Giant_Cell"                                                                                                                                 
[33823] "Malignant_Neuroendocrine_Small_Cell"                                                                                                                                  
[33824] "Malignant_Neuroendocrine_Large_Cell"                                                                                                                                  
[33825] "Malignant_Epithelial_Large_Cell"                                                                                                                                      
[33826] "Neoplastic_Spindle_Cell"                                                                                                                                              
[33827] "Malignant_Epithelial_Giant_Cell"                                                                                                                                      
[33828] "Malignant_Neuroendocrine_Cell"                                                                                                                                        
[33829] "Bizarre_Neoplastic_Stromal_Giant_Cell"                                                                                                                                
[33830] "Osteoclast-Like_Giant_Cell"                                                                                                                                           
[33831] "Giant_Cell_with_Myoblastic_Differentiation"                                                                                                                           
[33832] "Abnormal_Mesothelial_Cell"                                                                                                                                            
[33833] "Reactive_Mesothelial_Cell"                                                                                                                                            
[33834] "Malignant_Mesothelial_Cell"                                                                                                                                           
[33835] "Abnormal_Macrophage"                                                                                                                                                  
[33836] "Lipid-Laden_Macrophage"                                                                                                                                               
[33837] "Tingible_Body_Macrophage"                                                                                                                                             
[33838] "Neoplastic_Thyroid_Follicular_Cell"                                                                                                                                   
[33839] "Malignant_Thyroid_Follicular_Cell"                                                                                                                                    
[33840] "Metaplastic_Glandular_Cell"                                                                                                                                           
[33841] "High_Grade_Malignant_Transitional_Cell"                                                                                                                               
[33842] "Low_Grade_Malignant_Transitional_Cell"                                                                                                                                
[33843] "Adenocarcinoma_Granular_Cell"                                                                                                                                         
[33844] "Adenocarcinoma_Cell_with_Perinuclear_Clearing"                                                                                                                        
[33845] "Giant_Astrocyte"                                                                                                                                                      
[33846] "Abnormal_Connective_and_Soft_Tissue_Cell"                                                                                                                             
[33847] "Niemann-Pick_Cell"                                                                                                                                                    
[33848] "Xanthoma_Cell"                                                                                                                                                        
[33849] "Foamy_Macrophage"                                                                                                                                                     
[33850] "Hemosiderin-Laden_Macrophage"                                                                                                                                         
[33851] "Anaplastic_Carcinoma_Cell"                                                                                                                                            
[33852] "Neoplastic_Epithelial_Spindle_Cell"                                                                                                                                   
[33853] "Polygonal_Adenocarcinoma_Cell_with_Eosinophilic_Cytoplasm"                                                                                                            
[33854] "Neoplastic_Polygonal_Cell"                                                                                                                                            
[33855] "Neoplastic_Polygonal_Cell_with_Abundant_Granular_Cytoplasm"                                                                                                           
[33856] "Malignant_Neuroendocrine_Small_Cell_with_Round_Nucleus"                                                                                                               
[33857] "Malignant_Neuroendocrine_Spindle_Cell"                                                                                                                                
[33858] "Malignant_Neuroendocrine_Polygonal_Cell"                                                                                                                              
[33859] "Mucin-Producing_Adenocarcinoma_Cell"                                                                                                                                  
[33860] "Giant_Adenocarcinoma_Cell"                                                                                                                                            
[33861] "Ductal_Carcinoma_Cell"                                                                                                                                                
[33862] "Acinar_Carcinoma_Cell"                                                                                                                                                
[33863] "Malignant_Small_Cell"                                                                                                                                                 
[33864] "Malignant_Small_Hyperchromatic_Cell"                                                                                                                                  
[33865] "Neoplastic_Melanocyte"                                                                                                                                                
[33866] "Balloon_Nevus_Cell"                                                                                                                                                   
[33867] "Nevus_Cell_A-Type"                                                                                                                                                    
[33868] "Nevus_Cell_B-Type"                                                                                                                                                    
[33869] "Nevus_Cell_C-Type"                                                                                                                                                    
[33870] "Atypical_Melanocyte"                                                                                                                                                  
[33871] "Atypical_Spindle_Melanocyte"                                                                                                                                          
[33872] "Spindle_Melanocyte"                                                                                                                                                   
[33873] "Epithelioid_Melanocyte"                                                                                                                                               
[33874] "Pagetoid_Cell"                                                                                                                                                        
[33875] "Epithelioid_Melanoma_Cell"                                                                                                                                            
[33876] "Melanoma_Cell"                                                                                                                                                        
[33877] "Spindle_Melanoma_Cell"                                                                                                                                                
[33878] "Metaplastic_Hurthle_Cell"                                                                                                                                             
[33879] "Adenocarcinoma_Cell_with_Intranuclear_Inclusion"                                                                                                                      
[33880] "Neoplastic_Ductal_Epithelial_Cell"                                                                                                                                    
[33881] "Neoplastic_Lobular_Epithelial_Cell"                                                                                                                                   
[33882] "Lobular_Carcinoma_Cell"                                                                                                                                               
[33883] "Adenocarcinoma_Cell_with_Eosinophilic_Granular_Cytoplasm"                                                                                                             
[33884] "Neoplastic_Glandular_Cell_with_Eosinophilic_Granular_Cytoplasm"                                                                                                       
[33885] "Metaplastic_Apocrine_Cell"                                                                                                                                            
[33886] "Atypical_Ductal_Epithelial_Cell"                                                                                                                                      
[33887] "Malignant_Polygonal_Cell_with_Abundant_Granular_Cytoplasm"                                                                                                            
[33888] "Atypical_Lobular_Epithelial_Cell"                                                                                                                                     
[33889] "Neoplastic_Plump_Epithelial_Cell"                                                                                                                                     
[33890] "Neoplastic_Connective_and_Soft_Tissue_Cell"                                                                                                                           
[33891] "Neoplastic_Histiocyte"                                                                                                                                                
[33892] "Neoplastic_Langerhans_Cell"                                                                                                                                           
[33893] "Malignant_Langerhans_Cell"                                                                                                                                            
[33894] "Mucin-Producing_Neoplastic_Epithelial_Cell"                                                                                                                           
[33895] "Neoplastic_Interdigitating_Dendritic_Cell"                                                                                                                            
[33896] "Neoplastic_Follicular_Dendritic_Cell"                                                                                                                                 
[33897] "Neoplastic_Granulosa_Cell"                                                                                                                                            
[33898] "Neoplastic_Sertoli_Cell"                                                                                                                                              
[33899] "Neoplastic_Leydig_Cell"                                                                                                                                               
[33900] "Neoplastic_Primitive_Germ_Cell"                                                                                                                                       
[33901] "Neoplastic_Sex_Cord-Stromal_Cell"                                                                                                                                     
[33902] "Neoplastic_Stellate_Cell"                                                                                                                                             
[33903] "Neoplastic_Osteoblast"                                                                                                                                                
[33904] "Malignant_Osteoblast"                                                                                                                                                 
[33905] "Signet_Ring_Stromal_Cell"                                                                                                                                             
[33906] "Neoplastic_Germ_Cell"                                                                                                                                                 
[33907] "Neoplastic_Large_Germ_Cell"                                                                                                                                           
[33908] "Neoplastic_Large_Pleomorphic_Germ_Cell"                                                                                                                               
[33909] "Neoplastic_Syncytiotrophoblastic_Cell"                                                                                                                                
[33910] "Primitive_Mesenchymal_Cell"                                                                                                                                           
[33911] "Apocrine_Ductal_Carcinoma_Cell"                                                                                                                                       
[33912] "Atypical_Metaplastic_Apocrine_Cell"                                                                                                                                   
[33913] "Primitive_Mesenchymal_Round_Cell"                                                                                                                                     
[33914] "Atypical_Transitional_Cell"                                                                                                                                           
[33915] "Atypical_Glandular_Cell"                                                                                                                                              
[33916] "Atypical_Squamous_Cell"                                                                                                                                               
[33917] "Atypical_Epithelial_Cell"                                                                                                                                             
[33918] "Reactive_Transitional_Cell"                                                                                                                                           
[33919] "Malignant_Neuroendocrine_Cell_with_Moderate_Cytoplasm"                                                                                                                
[33920] "Malignant_Neuroendocrine_Cell_with_Abundant_Cytoplasm"                                                                                                                
[33921] "Neoplastic_Prolactin_Cell"                                                                                                                                            
[33922] "Neoplastic_Growth_Hormone_Cell"                                                                                                                                       
[33923] "Neoplastic_Corticotroph_Cell"                                                                                                                                         
[33924] "Neoplastic_Gonadotroph_Cell"                                                                                                                                          
[33925] "Neoplastic_Thyrotroph_Cell"                                                                                                                                           
[33926] "Neoplastic_Endocrine_Null_Cell"                                                                                                                                       
[33927] "Neoplastic_Acidophilic_Stem_Cell"                                                                                                                                     
[33928] "Neoplastic_Endocrine_Cell"                                                                                                                                            
[33929] "Neoplastic_Fasciculata_Cell"                                                                                                                                          
[33930] "Neoplastic_Glomerulosa_Cell"                                                                                                                                          
[33931] "Primitive_Mesenchymal_Stellate_Cell"                                                                                                                                  
[33932] "Malignant_Endocrine_Cell"                                                                                                                                             
[33933] "Neoplastic_Endocrine_Clear_Cell"                                                                                                                                      
[33934] "Neoplastic_Endocrine_Compact_Cell"                                                                                                                                    
[33935] "Polygonal_or_Elongated_Mononuclear_Mesenchymal_Cell"                                                                                                                  
[33936] "Neoplastic_Neuroendocrine_Polygonal_Cell"                                                                                                                             
[33937] "Neoplastic_Neuroendocrine_Polygonal_Cell_with_Cytoplasmic_Eosinophilic_Globules"                                                                                      
[33938] "Neoplastic_Neuroendocrine_Spindle_Cell"                                                                                                                               
[33939] "Neoplastic_Muscle_Cell"                                                                                                                                               
[33940] "Neoplastic_Smooth_Muscle_Cell"                                                                                                                                        
[33941] "Neoplastic_Endocrine_Chief_Cell"                                                                                                                                      
[33942] "Neoplastic_Clear_Cell_Oncocyte"                                                                                                                                       
[33943] "Malignant_Clear_Cell_Oncocyte"                                                                                                                                        
[33944] "Neoplastic_Oncocyte"                                                                                                                                                  
[33945] "Malignant_Oncocyte"                                                                                                                                                   
[33946] "Neoplastic_Acinar_Cell"                                                                                                                                               
[33947] "Malignant_Small_Undifferentiated_Cell"                                                                                                                                
[33948] "Spindle_Shaped_Smooth_Muscle_Cell"                                                                                                                                    
[33949] "Pleomorphic_Smooth_Muscle_Cell"                                                                                                                                       
[33950] "Neoplastic_Striated_Muscle_Cell"                                                                                                                                      
[33951] "Strap-Like_Striated_Muscle_Cell"                                                                                                                                      
[33952] "Primitive_Striated_Muscle_Cell"                                                                                                                                       
[33953] "Round_Striated_Muscle_Cell"                                                                                                                                           
[33954] "Round_Cell_with_Primitive_Myoblastic_Differentiation"                                                                                                                 
[33955] "Spindle_Cell_Myoblast"                                                                                                                                                
[33956] "Bizarre_Cell_with_Evidence_of_Skeletal_Muscle_Differentiation"                                                                                                        
[33957] "Neoplastic_Connective_and_Soft_Tissue_Spindle_Cell"                                                                                                                   
[33958] "Spindle-Shaped_Fibroblast"                                                                                                                                            
[33959] "Atypical_Fibroblastic_Spindle_Cell"                                                                                                                                   
[33960] "Spindle-Shaped_Myofibroblast"                                                                                                                                         
[33961] "Immature_Spindle_Cell"                                                                                                                                                
[33962] "Neoplastic_Fibroblast-Like_Cell"                                                                                                                                      
[33963] "Neoplastic_Histiocytic_Cell"                                                                                                                                          
[33964] "Neoplastic_Histiocyte-Like_Cell"                                                                                                                                      
[33965] "Neoplastic_Fibrohistiocytic_Cell"                                                                                                                                     
[33966] "Neoplastic_Fusiform_Cell"                                                                                                                                             
[33967] "Neoplastic_Myoid_Cell"                                                                                                                                                
[33968] "Glomus_Cell"                                                                                                                                                          
[33969] "Atypical_Glomus_Cell"                                                                                                                                                 
[33970] "Polygonal_Brown_Fat_Cell"                                                                                                                                             
[33971] "Multivacuolated_Brown_Fat_Cell"                                                                                                                                       
[33972] "Eosinophilic_Brown_Fat_Cell"                                                                                                                                          
[33973] "Pale_Brown_Fat_Cell"                                                                                                                                                  
[33974] "Multilobated_Lipoblast-Like_Cell"                                                                                                                                     
[33975] "Monovacuolated_Lipoblast"                                                                                                                                             
[33976] "Multivacuolated_Lipoblast"                                                                                                                                            
[33977] "Pleomorphic_Lipoblast"                                                                                                                                                
[33978] "Signet-Ring_Lipoblast"                                                                                                                                                
[33979] "Mature-Appearing_Adipocyte"                                                                                                                                           
[33980] "Atypical_Adipocyte"                                                                                                                                                   
[33981] "Adipocyte_with_Nuclear_Atypia"                                                                                                                                        
[33982] "Hyperchromatic_Adipocyte"                                                                                                                                             
[33983] "Hyperchromatic_Stromal_Cell"                                                                                                                                          
[33984] "Ganglion-Like_Cell"                                                                                                                                                   
[33985] "Chondrocyte-Like_Cell"                                                                                                                                                
[33986] "Neoplastic_Chondrocyte"                                                                                                                                               
[33987] "Atypical_Chondrocyte"                                                                                                                                                 
[33988] "Neoplastic_Chondroblast"                                                                                                                                              
[33989] "Neoplastic_Chondroblast-Like_Cell"                                                                                                                                    
[33990] "Abnormal_Hematopoietic_Cell"                                                                                                                                          
[33991] "Neoplastic_Lymphocyte"                                                                                                                                                
[33992] "Paraimmunoblast"                                                                                                                                                      
[33993] "Neoplastic_Small_to_Medium-Sized_Lymphocyte"                                                                                                                          
[33994] "Small_to_Medium-Sized_Lymphocyte_with_Pale_Cytoplasm"                                                                                                                 
[33995] "Neoplastic_Medium-Sized_to_Large_Lymphocyte"                                                                                                                          
[33996] "Lymphocyte_with_Basophilic_Villous_Cytoplasm"                                                                                                                         
[33997] "Neoplastic_Natural_Killer-Cell"                                                                                                                                       
[33998] "Pleomorphic_Lymphocyte"                                                                                                                                               
[33999] "Pleomorphic_B-Cell"                                                                                                                                                   
[34000] "Pleomorphic_T-Cell"                                                                                                                                                   
[34001] "Neoplastic_Small_Lymphocyte"                                                                                                                                          
[34002] "Small_Lymphocyte_with_Clumped_Chromatin"                                                                                                                              
[34003] "Lymphoplasmacytoid_Cell"                                                                                                                                              
[34004] "Centrocyte-Like_Cell"                                                                                                                                                 
[34005] "Neoplastic_Small_Cleaved_Cell"                                                                                                                                        
[34006] "Neoplastic_Monocytoid_B-Cell"                                                                                                                                         
[34007] "Neoplastic_Medium-Sized_Lymphocyte"                                                                                                                                   
[34008] "Medium-Sized_Lymphocyte_with_Basophilic_Cytoplasm"                                                                                                                    
[34009] "Medium-Sized_Lymphocyte_with_Eccentric_Basophilic_Cytoplasm"                                                                                                          
[34010] "Medium-Sized_Lymphocyte_with_Pale_Cytoplasm"                                                                                                                          
[34011] "Neoplastic_Large_Lymphocyte"                                                                                                                                          
[34012] "Neoplastic_Immunoblast"                                                                                                                                               
[34013] "Neoplastic_B-Immunoblast"                                                                                                                                             
[34014] "Plasmablastic_Immunoblast"                                                                                                                                            
[34015] "Neoplastic_T-Immunoblast"                                                                                                                                             
[34016] "Neoplastic_Large_B-Lymphocyte"                                                                                                                                        
[34017] "Neoplastic_Large_Non-Cleaved_Cell"                                                                                                                                    
[34018] "Anaplastic_Large_B-Cell"                                                                                                                                              
[34019] "Neoplastic_Large_T-Lymphocyte"                                                                                                                                        
[34020] "Anaplastic_Large_T-Cell"                                                                                                                                              
[34021] "Anaplastic_Large_Lymphocyte"                                                                                                                                          
[34022] "Neoplastic_Large_Granular_Lymphocyte"                                                                                                                                 
[34023] "Neoplastic_Large_Cleaved_Cell"                                                                                                                                        
[34024] "Hodgkin_s_Cell"                                                                                                                                                       
[34025] "Binucleated_Reed-Sternberg_Cell"                                                                                                                                      
[34026] "Lacunar_Reed-Sternberg_Cell"                                                                                                                                          
[34027] "Reed-Sternberg-Like_Cell"                                                                                                                                             
[34028] "Mummified_Cell"                                                                                                                                                       
[34029] "Hodgkin_s-Like_Cell"                                                                                                                                                  
[34030] "Lymphocytic_and_Histiocytic_Cell"                                                                                                                                     
[34031] "Lymphocyte_with_Abundant_Pale_Cytoplasm"                                                                                                                              
[34032] "Abnormal_Neutrophil"                                                                                                                                                  
[34033] "Toxic_Neutrophil"                                                                                                                                                     
[34034] "Dysplastic_Neutrophil"                                                                                                                                                
[34035] "Abnormal_Eosinophil"                                                                                                                                                  
[34036] "Hypochromic_Red_Blood_Cell"                                                                                                                                           
[34037] "Microcytic_Red_Blood_Cell"                                                                                                                                            
[34038] "Neoplastic_Epithelial_Polygonal_Cell"                                                                                                                                 
[34039] "Malignant_Basaloid_Squamous_Cell"                                                                                                                                     
[34040] "Abnormal_Platelet"                                                                                                                                                    
[34041] "Large_Atypical_Platelet"                                                                                                                                              
[34042] "Abnormal_Monocyte"                                                                                                                                                    
[34043] "Neoplastic_Monocyte"                                                                                                                                                  
[34044] "Abnormal_Myeloid_Cell"                                                                                                                                                
[34045] "Abnormal_Megakaryocyte"                                                                                                                                               
[34046] "Large_Megakaryocyte"                                                                                                                                                  
[34047] "Giant_Megakaryocyte"                                                                                                                                                  
[34048] "Dysplastic_Megakaryocyte"                                                                                                                                             
[34049] "Hypolobated_Megakaryocyte"                                                                                                                                            
[34050] "Monolobed_Megakaryocyte"                                                                                                                                              
[34051] "Hyperchromatic_Megakaryocyte"                                                                                                                                         
[34052] "Abnormal_Granulocyte"                                                                                                                                                 
[34053] "Dysplastic_Granulocyte"                                                                                                                                               
[34054] "Faggot_Cell"                                                                                                                                                          
[34055] "Abnormal_Erythroid_Precursor"                                                                                                                                         
[34056] "Dysplastic_Erythroid_Precursor"                                                                                                                                       
[34057] "Large_Multinucleated_Erythroid_Cell"                                                                                                                                  
[34058] "Dysplastic_Erythroblast"                                                                                                                                              
[34059] "Abnormal_Erythroblast"                                                                                                                                                
[34060] "Ringed_Sideroblast"                                                                                                                                                   
[34061] "Large_Erythroblast"                                                                                                                                                   
[34062] "Neoplastic_Hematopoietic_Cell"                                                                                                                                        
[34063] "Clonal_Hematopoietic_Stem_Cell"                                                                                                                                       
[34064] "Neoplastic_Mast_Cell"                                                                                                                                                 
[34065] "Immature_Mast_Cell"                                                                                                                                                   
[34066] "Neoplastic_Blast"                                                                                                                                                     
[34067] "Neoplastic_Myeloblast"                                                                                                                                                
[34068] "Neoplastic_Blast_with_Basophilic_Cytoplasm"                                                                                                                           
[34069] "Neoplastic_Myeloid_Blast"                                                                                                                                             
[34070] "Neoplastic_Megakaryoblast"                                                                                                                                            
[34071] "Neoplastic_B-Lymphoblast"                                                                                                                                             
[34072] "Neoplastic_T-Lymphoblast"                                                                                                                                             
[34073] "Neoplastic_Promyelocyte"                                                                                                                                              
[34074] "Hypergranular_Promyelocyte"                                                                                                                                           
[34075] "Hypogranular_Promyelocyte"                                                                                                                                            
[34076] "Neoplastic_Promonocyte"                                                                                                                                               
[34077] "Neoplastic_Neutrophilic_Precursor"                                                                                                                                    
[34078] "Neoplastic_Plasma_Cell"                                                                                                                                               
[34079] "Pseudo-Gaucher_Cell"                                                                                                                                                  
[34080] "Mott_Cell"                                                                                                                                                            
[34081] "Flame_Cell"                                                                                                                                                           
[34082] "Anaplastic_Plasma_Cell"                                                                                                                                               
[34083] "Plasmablast"                                                                                                                                                          
[34084] "Pleomorphic_Plasma_Cell"                                                                                                                                              
[34085] "Hyperchromatic_Spindle_Cell"                                                                                                                                          
[34086] "Undifferentiated_Carcinoma_Cell"                                                                                                                                      
[34087] "Abnormal_Endothelial_Cell"                                                                                                                                            
[34088] "Atypical_Endothelial_Cell"                                                                                                                                            
[34089] "Neoplastic_Endothelial_Cell"                                                                                                                                          
[34090] "Hyperchromatic_Endothelial_Cell"                                                                                                                                      
[34091] "Primitive_Mesenchymal_Plump_Cell"                                                                                                                                     
[34092] "Vacuolated_Endothelial_Cell"                                                                                                                                          
[34093] "Spindle_Endothelial_Cell"                                                                                                                                             
[34094] "Epithelioid_Endothelial_Cell"                                                                                                                                         
[34095] "Large_Round_Epithelioid_Endothelial_Cell"                                                                                                                             
[34096] "Neoplastic_Hurthle_Cell"                                                                                                                                              
[34097] "Metaplastic_Columnar_Cell"                                                                                                                                            
[34098] "Malignant_Hurthle_Cell"                                                                                                                                               
[34099] "Neoplastic_Merkel_Cell"                                                                                                                                               
[34100] "Neoplastic_Round_Cell"                                                                                                                                                
[34101] "Neoplastic_Small_Round_Cell"                                                                                                                                          
[34102] "Neoplastic_Round_Cell_with_Neuronal_Differentiation"                                                                                                                  
[34103] "Neoplastic_Round_Cell_with_Lipomatous_Differentiation"                                                                                                                
[34104] "Neoplastic_Small_Cell"                                                                                                                                                
[34105] "Neoplastic_Epithelioid_Cell"                                                                                                                                          
[34106] "Neoplastic_Cell_with_Eosinophilic_Cytoplasm"                                                                                                                          
[34107] "Neoplastic_Large_Cell_with_Abundant_Eosinophilic_Cytoplasm"                                                                                                           
[34108] "Neoplastic_Large_Cell_with_Abundant_Cytoplasm"                                                                                                                        
[34109] "Adenocarcinoma_Spindle_Cell"                                                                                                                                          
[34110] "Malignant_Epithelial_Spindle_Cell"                                                                                                                                    
[34111] "Anaplastic_Melanocyte"                                                                                                                                                
[34112] "Pleomorphic_Cell"                                                                                                                                                     
[34113] "Pleomorphic_Connective_and_Soft_Tissue_Cell"                                                                                                                          
[34114] "Neoplastic_Fetal_Epithelial_Cell"                                                                                                                                     
[34115] "Neoplastic_Serous_Epithelial_Cell"                                                                                                                                    
[34116] "Serous_Adenocarcinoma_Cell"                                                                                                                                           
[34117] "Neoplastic_Mucinous_Epithelial_Cell"                                                                                                                                  
[34118] "Mucinous_Adenocarcinoma_Cell"                                                                                                                                         
[34119] "Atypical_Epithelioid_Cell"                                                                                                                                            
[34120] "Immature_Myxoid_Mesenchymal_Cell"                                                                                                                                     
[34121] "Immature_Spindle_Mesenchymal_Cell"                                                                                                                                    
[34122] "Neoplastic_Blastemal_Cell"                                                                                                                                            
[34123] "Neoplastic_Glandular_Cell_with_Enlarged_Nucleus"                                                                                                                      
[34124] "Neoplastic_Spindle-Shaped_to_Round_Cell"                                                                                                                              
[34125] "Neoplastic_Multinucleated_Stromal_Cell"                                                                                                                               
[34126] "Neoplastic_Neuroepithelial_Cell"                                                                                                                                      
[34127] "Neoplastic_Glial_Cell"                                                                                                                                                
[34128] "Neoplastic_Astrocyte"                                                                                                                                                 
[34129] "Neoplastic_Glandular_Cell_with_Enlarged_Nucleus_and_Prominent_Nucleolus"                                                                                              
[34130] "Fibrillary_Neoplastic_Astrocyte"                                                                                                                                      
[34131] "Neoplastic_Germ_Cell_with_Clear_to_Lightly_Eosinophilic_Cytoplasm"                                                                                                    
[34132] "Small_Lymphocyte-Like_Neoplastic_Germ_Cell"                                                                                                                           
[34133] "Gemistocytic_Neoplastic_Astrocyte"                                                                                                                                    
[34134] "Intermediate-Sized_Neoplastic_Germ_Cell"                                                                                                                              
[34135] "Giant_Neoplastic_Germ_Cell"                                                                                                                                           
[34136] "Neoplastic_Astrocyte_with_Few_Flaccid_Processes"                                                                                                                      
[34137] "Anaplastic_Astrocyte"                                                                                                                                                 
[34138] "Poorly_Differentiated_Neoplastic_Astrocyte"                                                                                                                           
[34139] "Bipolar_Cell_with_Rosenthal_Fiber"                                                                                                                                    
[34140] "Xanthomatous_Astrocyte"                                                                                                                                               
[34141] "Neoplastic_Cytotrophoblastic_Cell"                                                                                                                                    
[34142] "Neoplastic_Oligodendroglia_Cell"                                                                                                                                      
[34143] "Neoplastic_Intermediate_Type_Trophoblastic_Cell"                                                                                                                      
[34144] "Neoplastic_Ependymal_Cell"                                                                                                                                            
[34145] "Neoplastic_Elongated_Glial_Cell"                                                                                                                                      
[34146] "Neuroblastic_Cell"                                                                                                                                                    
[34147] "Neoplastic_Ganglion_Cell"                                                                                                                                             
[34148] "Neoplastic_Oligodendroglia-Like_Cell"                                                                                                                                 
[34149] "Neoplastic_Neural_Crest_Cell"                                                                                                                                         
[34150] "Rhabdoid_Cell"                                                                                                                                                        
[34151] "Neoplastic_Stromal_Cell"                                                                                                                                              
[34152] "Neoplastic_Schwann_Cell"                                                                                                                                              
[34153] "Perineurial-Like_Cell"                                                                                                                                                
[34154] "Malignant_Stromal_Cell"                                                                                                                                               
[34155] "Neoplastic_Perineurial_Cell"                                                                                                                                          
[34156] "Neoplastic_Meningothelial_Cell"                                                                                                                                       
[34157] "Spindle-Shaped_Meningothelial_Cell"                                                                                                                                   
[34158] "Meningothelial_Cell_with_Elongated_Processes"                                                                                                                         
[34159] "Pleomorphic_Meningothelial_Cell"                                                                                                                                      
[34160] "Eosinophilic_Meningothelial_Cell"                                                                                                                                     
[34161] "Meningothelial_Cell_with_Clear_Cytoplasm"                                                                                                                             
[34162] "Small_Meningothelial_Cell"                                                                                                                                            
[34163] "Neoplastic_Large_Cell"                                                                                                                                                
[34164] "Neoplastic_Large_Cell_with_Abundant_Pale_Cytoplasm"                                                                                                                   
[34165] "Neoplastic_Polygonal_Cell_with_Eosinophilic_Cytoplasm"                                                                                                                
[34166] "Atypical_Lymphocyte"                                                                                                                                                  
[34167] "Neoplastic_Eosinophilic_Cell_Oncocyte"                                                                                                                                
[34168] "Malignant_Eosinophilic_Cell_Oncocyte"                                                                                                                                 
[34169] "Metaplastic_Myoepithelial_Cell"                                                                                                                                       
[34170] "Multilobated_Neoplastic_B-Lymphocyte"                                                                                                                                 
[34171] "Pleomorphic_Epithelial_Cell"                                                                                                                                          
[34172] "Pleomorphic_Adenocarcinoma_Cell"                                                                                                                                      
[34173] "Hypolobated_Neutrophil"                                                                                                                                               
[34174] "Neutrophil_with_Abnormal_Cytoplasmic_Granulation"                                                                                                                     
[34175] "Neutriphil_with_Cytoplasmic_Hypogranularity"                                                                                                                          
[34176] "Neutriphil_with_pseudo_Chediak-Higashi_Granules"                                                                                                                      
[34177] "Neoplastic_Myeloblast_with_Abundant_Basophilic_Cytoplasm"                                                                                                             
[34178] "Neoplastic_Medium-Sized_Myeloblast_with_Basophilic_Agranular_Cytoplasm"                                                                                               
[34179] "Neoplastic_Myeloblast_with_Azurophilic_Granules"                                                                                                                      
[34180] "Neoplastic_Myeloblast_without_Azurophilic_Granules"                                                                                                                   
[34181] "Medium-Sized_Neoplastic_Blast_with_Coarse_Cytoplasmic_Basophilic_Granules"                                                                                            
[34182] "Neoplastic_Monoblast"                                                                                                                                                 
[34183] "Neoplastic_Prolymphocyte"                                                                                                                                             
[34184] "Neoplastic_B-Prolymphocyte"                                                                                                                                           
[34185] "Neoplastic_T-Prolymphocyte"                                                                                                                                           
[34186] "Gain_of_Chromosome_12q13"                                                                                                                                             
[34187] "del_6q25-27"                                                                                                                                                          
[34188] "del_17q25"                                                                                                                                                            
[34189] "t_9_22_q22-31_q12"                                                                                                                                                    
[34190] "Trisomy_11"                                                                                                                                                           
[34191] "Intravascular_Metastasis"                                                                                                                                             
[34192] "ALK-Positive_Anaplastic_Large_Cell_Lymphoma"                                                                                                                          
[34193] "ALK-Negative_Anaplastic_Large_Cell_Lymphoma"                                                                                                                          
[34194] "Primary_Systemic_ALK-Positive_Anaplastic_Large_Cell_Lymphoma"                                                                                                         
[34195] "Primary_Systemic_ALK-Negative_Anaplastic_Large_Cell_Lymphoma"                                                                                                         
[34196] "Pure_Bronchiolo-Alveolar_Lung_Carcinoma"                                                                                                                              
[34197] "Mixed_Adenocarcinoma-Bronchiolo-Alveolar_Lung_Carcinoma"                                                                                                              
[34198] "Lung_Papillary-Adenocarcinoma"                                                                                                                                        
[34199] "t_16_17_q22_p13"                                                                                                                                                      
[34200] "Chronic_Lymphocytic_Leukemia_Small_Lymphocytic_Lymphoma_with_Immunoglobulin_Heavy_Chain_Variable-Region_Gene_Somatic_Hypermutation"                                   
[34201] "Chronic_Lymphocytic_Leukemia_with_Immunoglobulin_Heavy_Chain_Variable-Region_Gene_Somatic_Hypermutation"                                                              
[34202] "Small_Lymphocytic_Lymphoma_with_Immunoglobulin_Heavy_Chain_Variable-Region_Gene_Somatic_Hypermutation"                                                                
[34203] "Chronic_Lymphocytic_Leukemia_Small_Lymphocytic_Lymphoma_with_Unmutated_Immunoglobulin_Heavy_Chain-Region_Gene"                                                        
[34204] "Chronic_Lymphocytic_Leukemia_with_Unmutated_Immunoglobulin_Heavy_Chain-Region_Gene"                                                                                   
[34205] "Small_Lymphocytic_Lymphoma_with_Unmutated_Immunoglobulin_Heavy_Chain-Region_Gene"                                                                                     
[34206] "ZAP-70_Messenger_RNA_Overexpression"                                                                                                                                  
[34207] "Rearrangement_of_2p23"                                                                                                                                                
[34208] "Blastoid_Follicular_Lymphoma"                                                                                                                                         
[34209] "Renal_Neoplasm_with_t_6_11_p21_q12"                                                                                                                                   
[34210] "t_6_11_p21_q12"                                                                                                                                                       
[34211] "Solid_Pseudopapillary_Tumor_of_the_Pancreas"                                                                                                                          
[34212] "Intraductal_Pancreatic_Mucinous_Neoplasm"                                                                                                                             
[34213] "Colloid_Carcinoma_of_the_Pancreas"                                                                                                                                    
[34214] "Intraductal_Papillary_Mucinous_Neoplasm_of_the_Biliary_Tract"                                                                                                         
[34215] "CLTC-ALK_Fusion_Protein_Expression"                                                                                                                                   
[34216] "FIP1L1-PDGFRalpha_Fusion_Protein_Expression"                                                                                                                          
[34217] "AML1-ETO_Fusion_Protein_Expression"                                                                                                                                   
[34218] "CBFbeta-MYH11_Fusion_Protein_Expression"                                                                                                                              
[34219] "PLZF-RARalpha_Fusion_Protein_Expression"                                                                                                                              
[34220] "NPM-RARalpha_Fusion_Protein_Expression"                                                                                                                               
[34221] "NuMA-RARalpha_Fusion_Protein_Expression"                                                                                                                              
[34222] "PML-RARalpha_Fusion_Protein_Expression"                                                                                                                               
[34223] "EWS-FL1_Fusion_Protein_Expression"                                                                                                                                    
[34224] "E2A-PBX1_Fusion_Protein_Expression"                                                                                                                                   
[34225] "TEL-AML1_Fusion_Protein_Expression"                                                                                                                                   
[34226] "MLL-AF4_Fusion_Protein_Expression"                                                                                                                                    
[34227] "EWS-ERG_Fusion_Protein_Expression"                                                                                                                                    
[34228] "EWS-ETV1_Fusion_Protein_Expression"                                                                                                                                   
[34229] "EWS-E1AF_Fusion_Protein_Expression"                                                                                                                                   
[34230] "EWS-ATF1_Fusion_Protein_Expression"                                                                                                                                   
[34231] "EWS-NR4A3_Fusion_Protein_Expression"                                                                                                                                  
[34232] "RBP56-NR4A3_Fusion_Protein_Expression"                                                                                                                                
[34233] "TCF12-NR4A3_Fusion_Protein_Expression"                                                                                                                                
[34234] "EWS-WT1_Fusion_Protein_Expression"                                                                                                                                    
[34235] "FUS-DDIT3_Fusion_Protein_Expression"                                                                                                                                  
[34236] "PAX3-FKHR_Fusion_Protein_Expression"                                                                                                                                  
[34237] "PAX7-FKHR_Fusion_Protein_Expression"                                                                                                                                  
[34238] "COL1A2-PLAG1_Fusion_Protein_Expression"                                                                                                                               
[34239] "HAS2-PLAG1_Fusion_Protein_Expression"                                                                                                                                 
[34240] "ETV6-NTRK3_Fusion_Protein_Expression"                                                                                                                                 
[34241] "FUS-ATF1_Fusion_Protein_Expression"                                                                                                                                   
[34242] "SS18-SSX1_Fusion_Protein_Expression"                                                                                                                                  
[34243] "SS18-SSX2_Fusion_Protein_Expression"                                                                                                                                  
[34244] "SS18-SSX4_Fusion_Protein_Expression"                                                                                                                                  
[34245] "ASPL-TFE3_Fusion_Protein_Expression"                                                                                                                                  
[34246] "t_2_22_q13_q22_t_3_18_p21_q23"                                                                                                                                        
[34247] "EWS-FEV_Fusion_Protein_Expression"                                                                                                                                    
[34248] "t_1_22_p36_1_q12"                                                                                                                                                     
[34249] "EWS-ZSG_Fusion_Protein_Expression"                                                                                                                                    
[34250] "HMGIC-LPP_Fusion_Protein_Expression"                                                                                                                                  
[34251] "Cardiovascular_System_Signs_and_Symptoms"                                                                                                                             
[34252] "Atypical_Squamous_Cell_cannot_exclude_a_High_Grade_Lesion"                                                                                                            
[34253] "Pancreatic_Foamy_Gland_Adenocarcinoma"                                                                                                                                
[34254] "Desmoplastic_Melanoma"                                                                                                                                                
[34255] "Paraganglioma-Like_Dermal_Melanocytic_Tumor"                                                                                                                          
[34256] "Benign_Pilomatrixoma"                                                                                                                                                 
[34257] "Classic_Lymphocytic_Colitis"                                                                                                                                          
[34258] "Hermansky-Pudlak_Syndrome"                                                                                                                                            
[34259] "Granulomatous_Colitis"                                                                                                                                                
[34260] "Mixed_Epithelial_Stromal_Tumor_of_the_Kidney"                                                                                                                         
[34261] "Benign_Mixed_Epithelial_Stromal_Tumor_of_the_Kidney"                                                                                                                  
[34262] "Malignant_Mixed_Epithelial_Stromal_Tumor_of_the_Kidney"                                                                                                               
[34263] "Bladder_Flat_Intraepithelial_Lesion"                                                                                                                                  
[34264] "Bladder_Flat_Carcinoma_in_Situ"                                                                                                                                       
[34265] "Atypical_Small_Acinar_Proliferation_of_the_Prostate_Gland"                                                                                                            
[34266] "Morular_Metaplasia_of_the_Endometrium"                                                                                                                                
[34267] "Endometrial_Glandular_Dysplasia"                                                                                                                                      
[34268] "Tyrosine_Phosphatase_SHP_Substrate-1"                                                                                                                                 
[34269] "Simplex_Differentiated_Type_of_Vulvar_Intraepithelial_Neoplasia"                                                                                                      
[34270] "Protein_Tyrosine_Phosphatase-IVA1"                                                                                                                                    
[34271] "Interferon_Alpha_Receptor_Complex"                                                                                                                                    
[34272] "IFNAR1_Gene"                                                                                                                                                          
[34273] "Interferon_Alpha-Beta_Receptor_Alpha_Chain"                                                                                                                           
[34274] "IFNAR2_Gene"                                                                                                                                                          
[34275] "Interferon_Alpha-Beta_Receptor_Beta_Chain"                                                                                                                            
[34276] "Interferon_Gamma_Receptor_Complex"                                                                                                                                    
[34277] "IFNGR1_Gene"                                                                                                                                                          
[34278] "_6q23-q24"                                                                                                                                                            
[34279] "_10q22"                                                                                                                                                               
[34280] "_8p11_2"                                                                                                                                                              
[34281] "_Xq24-q26"                                                                                                                                                            
[34282] "_Xp22_32"                                                                                                                                                             
[34283] "Interferon_Gamma_Receptor_Alpha_Chain"                                                                                                                                
[34284] "IFNGR2_Gene"                                                                                                                                                          
[34285] "Interferon_Gamma_Receptor_Beta_Chain"                                                                                                                                 
[34286] "Voltage-Dependant_Anion_Channel"                                                                                                                                      
[34287] "Head_and_Neck_Basaloid_Squamous_Cell_Carcinoma"                                                                                                                       
[34288] "VDAC1_Gene"                                                                                                                                                           
[34289] "Voltage-Dependent_Anion_Channel-1"                                                                                                                                    
[34290] "VDAC2_Gene"                                                                                                                                                           
[34291] "Voltage-Dependent_Anion_Channel-2"                                                                                                                                    
[34292] "VDAC3_Gene"                                                                                                                                                           
[34293] "Voltage-Dependent_Anion-Channel-3"                                                                                                                                    
[34294] "Adenosine_Nucleotide_Transporter"                                                                                                                                     
[34295] "SLC25A4_Gene"                                                                                                                                                         
[34296] "Adenine_Nucleotide_Translocator-1"                                                                                                                                    
[34297] "SLC25A5_Gene"                                                                                                                                                         
[34298] "Adenine_Nucleotide_Translocator-2"                                                                                                                                    
[34299] "SLC25A6_Gene"                                                                                                                                                         
[34300] "Adenine_Nucleotide_Translocator-3"                                                                                                                                    
[34301] "Multicentric_Papillary_Thyroid_Carcinoma"                                                                                                                             
[34302] "Reactive_Lymphocytosis"                                                                                                                                               
[34303] "X-Chromosome_Aberration-Related_Renal_Cell_Carcinoma"                                                                                                                 
[34304] "Focal_Segmental_Glomerulosclerosis"                                                                                                                                   
[34305] "Protein_Tyrosine_Phosphatase_Receptor_Type_Epsilon_Isoform-1"                                                                                                         
[34306] "Protein_Tyrosine_Phosphatase_Epsilon_Isoform-2"                                                                                                                       
[34307] "Protein_Tyrosine_Phosphatase_Receptor_Type-G"                                                                                                                         
[34308] "Loss_of_Chromosome_11q"                                                                                                                                               
[34309] "Protein_Tyrosine_Phosphatase_Receptor_Type-J"                                                                                                                         
[34310] "Protein_Tyrosine_Phosphatase-PCPTP1"                                                                                                                                  
[34311] "Protein_Tyrosine_Phosphatase_Receptor_Type-T"                                                                                                                         
[34312] "_Xp22_33"                                                                                                                                                             
[34313] "Protein_Phosphatase-2A-48kDa_Regulatory_Subunit"                                                                                                                      
[34314] "_101_H_Mouse"                                                                                                                                                         
[34315] "_101_Rl_Mouse"                                                                                                                                                        
[34316] "_129_Sv_Mouse"                                                                                                                                                        
[34317] "_129P1_Re_Mouse"                                                                                                                                                      
[34318] "_129P1_ReJ_Mouse"                                                                                                                                                     
[34319] "_129P1_ReJLacFib_Mouse"                                                                                                                                               
[34320] "_129P2_Ola_Mouse"                                                                                                                                                     
[34321] "_129P2_OlaHsd_Mouse"                                                                                                                                                  
[34322] "_129P2_SvOla_Mouse"                                                                                                                                                   
[34323] "_129P3_J_Mouse"                                                                                                                                                       
[34324] "_129P3_JEmsJ_Mouse"                                                                                                                                                   
[34325] "_129P4_Rr_Mouse"                                                                                                                                                      
[34326] "_129P4_RrJ_Mouse"                                                                                                                                                     
[34327] "_129P4_RrRkJ_Mouse"                                                                                                                                                   
[34328] "_129P4_RrSv_Mouse"                                                                                                                                                    
[34329] "_129S_Sv_Mouse"                                                                                                                                                       
[34330] "_129S_SvEv_Mouse"                                                                                                                                                     
[34331] "_129S1_Sv_Mouse"                                                                                                                                                      
[34332] "_129S1_SvImJ_Mouse"                                                                                                                                                   
[34333] "_129S2_SvPas_Mouse"                                                                                                                                                   
[34334] "_129S2_SvPasIco_Mouse"                                                                                                                                                
[34335] "_129S3_SvImJ_Mouse"                                                                                                                                                   
[34336] "_129S4_SvJae_Mouse"                                                                                                                                                   
[34337] "_129S4_SvJaeSor_Mouse"                                                                                                                                                
[34338] "_129S5_SvEvBrd_Mouse"                                                                                                                                                 
[34339] "_129S6_SvEvTac_Mouse"                                                                                                                                                 
[34340] "_129S7_SvEvBrd_Mouse"                                                                                                                                                 
[34341] "_129T2_SvEms_Mouse"                                                                                                                                                   
[34342] "_129T2_SvEmsJ_Mouse"                                                                                                                                                  
[34343] "_129X1_Sv_Mouse"                                                                                                                                                      
[34344] "A_Mouse"                                                                                                                                                              
[34345] "A_HeJ_Mouse"                                                                                                                                                          
[34346] "A_JOlaHsd_Mouse"                                                                                                                                                      
[34347] "A_WySnJ_Mouse"                                                                                                                                                        
[34348] "ABP_LeJ_Mouse"                                                                                                                                                        
[34349] "AEJ_Gn_Mouse"                                                                                                                                                         
[34350] "AKR_Mouse"                                                                                                                                                            
[34351] "AKR_N_Mouse"                                                                                                                                                          
[34352] "ALR_Mouse"                                                                                                                                                            
[34353] "BALB_c_Mouse"                                                                                                                                                         
[34354] "BALB_cAnPt_Mouse"                                                                                                                                                     
[34355] "BALB_cBy_Mouse"                                                                                                                                                       
[34356] "BALB_cByJ_Mouse"                                                                                                                                                      
[34357] "BALB_cCrl_Mouse"                                                                                                                                                      
[34358] "BALB_cHeA_Mouse"                                                                                                                                                      
[34359] "BALB_cRl_Mouse"                                                                                                                                                       
[34360] "BTBR_Mouse"                                                                                                                                                           
[34361] "BTBRTF_Mouse"                                                                                                                                                         
[34362] "C3H_Mouse"                                                                                                                                                            
[34363] "C3H_He_Mouse"                                                                                                                                                         
[34364] "C3H_HeH_Mouse"                                                                                                                                                        
[34365] "C3H_HeJ_Mouse"                                                                                                                                                        
[34366] "C3H_HeN_Mouse"                                                                                                                                                        
[34367] "C3H_HeOuJ_Mouse"                                                                                                                                                      
[34368] "C3H_HeSnJ_Mouse"                                                                                                                                                      
[34369] "C3H_Rl_Mouse"                                                                                                                                                         
[34370] "C3HeB_FeJ_Mouse"                                                                                                                                                      
[34371] "C57BL_Mouse"                                                                                                                                                          
[34372] "C57BL_10_Mouse"                                                                                                                                                       
[34373] "C57BL_10J_Mouse"                                                                                                                                                      
[34374] "C57BL_10ScSnJ_Mouse"                                                                                                                                                  
[34375] "C57BL_10Sn_Mouse"                                                                                                                                                     
[34376] "C57BL_10SnJ_Mouse"                                                                                                                                                    
[34377] "C57BL_6By_Mouse"                                                                                                                                                      
[34378] "C57BL_6ByJ_Mouse"                                                                                                                                                     
[34379] "C57BL_6JEiJ_Mouse"                                                                                                                                                    
[34380] "C57BL_6JN_Mouse"                                                                                                                                                      
[34381] "C57BL_6N_Mouse"                                                                                                                                                       
[34382] "C57BL_6Pas_Mouse"                                                                                                                                                     
[34383] "C57BL_Ka_Mouse"                                                                                                                                                       
[34384] "C57BLKS_J_Mouse"                                                                                                                                                      
[34385] "C57BR_Mouse"                                                                                                                                                          
[34386] "C57BR_cdJ_Mouse"                                                                                                                                                      
[34387] "C57L_Mouse"                                                                                                                                                           
[34388] "C58_Mouse"                                                                                                                                                            
[34389] "CASA_RkJ_Mouse"                                                                                                                                                       
[34390] "CAST_EiJ_Mouse"                                                                                                                                                       
[34391] "CBA_Mouse"                                                                                                                                                            
[34392] "CBA_Ca_Mouse"                                                                                                                                                         
[34393] "CBA_CaH_Mouse"                                                                                                                                                        
[34394] "CBA_CaJ_Mouse"                                                                                                                                                        
[34395] "CBA_J_Mouse"                                                                                                                                                          
[34396] "CBA_N_Mouse"                                                                                                                                                          
[34397] "CZECHII_Mouse"                                                                                                                                                        
[34398] "DBA_Mouse"                                                                                                                                                            
[34399] "DBA_1J_Mouse"                                                                                                                                                         
[34400] "DBA_1LacJ_Mouse"                                                                                                                                                      
[34401] "DBA_2N_Mouse"                                                                                                                                                         
[34402] "FVB_Mouse"                                                                                                                                                            
[34403] "HRS_J_Mouse"                                                                                                                                                          
[34404] "ICR_Mouse"                                                                                                                                                            
[34405] "LP_J_Mouse"                                                                                                                                                           
[34406] "LT_SvJ_Mouse"                                                                                                                                                         
[34407] "MOLD_RkJ_Mouse"                                                                                                                                                       
[34408] "MOLF_EiJ_Mouse"                                                                                                                                                       
[34409] "MRL_MpJ_Mouse"                                                                                                                                                        
[34410] "MSM_Ms_Mouse"                                                                                                                                                         
[34411] "NFS_N_Mouse"                                                                                                                                                          
[34412] "NMRI_Mouse"                                                                                                                                                           
[34413] "NOD_Mouse"                                                                                                                                                            
[34414] "NOD_Lt_Mouse"                                                                                                                                                         
[34415] "NOD_LtJ_Mouse"                                                                                                                                                        
[34416] "NOR_Mouse"                                                                                                                                                            
[34417] "NZB_Mouse"                                                                                                                                                            
[34418] "NZB_BlNJ_Mouse"                                                                                                                                                       
[34419] "NZC_Mouse"                                                                                                                                                            
[34420] "NZO_HlLt_Mouse"                                                                                                                                                       
[34421] "NZW_Mouse"                                                                                                                                                            
[34422] "NZW_LacJ_Mouse"                                                                                                                                                       
[34423] "O20_A_Mouse"                                                                                                                                                          
[34424] "PERA_EiJ_Mouse"                                                                                                                                                       
[34425] "PWK_Mouse"                                                                                                                                                            
[34426] "RBF_DnJ_Mouse"                                                                                                                                                        
[34427] "RIII_Mouse"                                                                                                                                                           
[34428] "RIII_2J_Mouse"                                                                                                                                                        
[34429] "RIIIS_J_Mouse"                                                                                                                                                        
[34430] "SEA_GnJ_Mouse"                                                                                                                                                        
[34431] "SEG_Mouse"                                                                                                                                                            
[34432] "SF_CamEiJ_Mouse"                                                                                                                                                      
[34433] "SJL_Mouse"                                                                                                                                                            
[34434] "SKIVE_Mouse"                                                                                                                                                          
[34435] "SPE_Pas_Mouse"                                                                                                                                                        
[34436] "SPRET_EiJ_Mouse"                                                                                                                                                      
[34437] "ST_bJ_Mouse"                                                                                                                                                          
[34438] "STS_A_Mouse"                                                                                                                                                          
[34439] "SWR_Mouse"                                                                                                                                                            
[34440] "WMP_Mouse"                                                                                                                                                            
[34441] "YBR_Ki_Mouse"                                                                                                                                                         
[34442] "Iodine_I_131_Tositumomab"                                                                                                                                             
[34443] "ABT-510"                                                                                                                                                              
[34444] "Autologous_Heat-Shock_Protein_70_Peptide_Vaccine"                                                                                                                     
[34445] "Survivin_Antigen"                                                                                                                                                     
[34446] "NA17-A_Antigen"                                                                                                                                                       
[34447] "DJ-927"                                                                                                                                                               
[34448] "Ixabepilone"                                                                                                                                                          
[34449] "Efaproxiral"                                                                                                                                                          
[34450] "EL625"                                                                                                                                                                
[34451] "Zebularine"                                                                                                                                                           
[34452] "Hypericin"                                                                                                                                                            
[34453] "C-C_Chemokine_Receptor_Type_9"                                                                                                                                        
[34454] "Ad5CMV-p53-Gene_Docetaxel_Doxorubicin"                                                                                                                                
[34455] "Autologous-Dendritic-Cells_CMV-pp65-Peptide"                                                                                                                          
[34456] "Autologous-Dendritic-Cells_Keyhole-Limpet-Hemocyanin_MAGE-3_Melan-A_Survivin-Antigen"                                                                                 
[34457] "Autologous-Dendritic-Cells_MAGE-3_Melan-A_Survivin-Antigen"                                                                                                           
[34458] "Autologous-Lymphocytes_gp100-Antigen_Interleukin-12_MAGE-3_Melan-A_NA17-A-Antigen"                                                                                    
[34459] "Autologous-Lymphocytes_gp100-Antigen_Interleukin-2_Interleukin-12_MAGE-3_Melan-A_NA17-A-Antigen"                                                                      
[34460] "Carboplatin_Doxorubicin-Hydrochloride-Liposome"                                                                                                                       
[34461] "Carboplatin_Neovastat_Paclitaxel"                                                                                                                                     
[34462] "Carboplatin_Paclitaxel_ZD-6474"                                                                                                                                       
[34463] "cBR96-Doxorubicin-Immunoconjugate_Gemcitabine"                                                                                                                        
[34464] "Cisplatin_Doxorubicin-Hydrochloride-Liposome_Mitomycin"                                                                                                               
[34465] "Cisplatin_Doxorubicin-Hydrochloride-Liposome_Paclitaxel"                                                                                                              
[34466] "Cisplatin_Doxorubicin_Methotrexate_Pamidronate-Disodium"                                                                                                              
[34467] "Cisplatin_Geldanamycin-Analogue_Gemcitabine"                                                                                                                          
[34468] "Cisplatin_Neovastat_Vinorelbine"                                                                                                                                      
[34469] "Cytarabine_Triapine"                                                                                                                                                  
[34470] "D1_3-MAGE-3-Fusion-Protein_SB-AS02B-Adjuvant"                                                                                                                         
[34471] "Docetaxel_Estramustine_Vitaxin-2_Zoledronate"                                                                                                                         
[34472] "Docetaxel_Geldanamycin-Analogue"                                                                                                                                      
[34473] "Docetaxel_Vitaxin-2"                                                                                                                                                  
[34474] "Flt3-Ligand_gp100-Antigen_Incomplete-Freund_s-Adjuvant_MART-1-Antigen_Tyrosinase"                                                                                     
[34475] "Flu-Matrix_gp100-Antigen_Keyhole-Limpet-Hemocyanin_MAGE-3-MART-1-Antigen_Melan-A_NY-ESO-B_QS21_Tyrosinase-Peptide"                                                    
[34476] "Flu-Matrix_gp100-Antigen_Keyhole-Limpet-Hemocyanin_MAGE-3_MART-1-Antigen_Melan-A_NY-ESO-B_Tyrosinase-Peptide"                                                         
[34477] "Flu-Matrix_gp100-Antigen_MAGE-3_MART-1-Antigen_Melan-A_NY-ESO-B_QS21_Tyrosinase-Peptide"                                                                              
[34478] "Flu-Matrix_gp100-Antigen_MAGE-3_MART-1-Antigen_Melan-A_NY-ESO-B_Tyrosinase-Peptide"                                                                                   
[34479] "Fludarabine_Triapine"                                                                                                                                                 
[34480] "Fluorouracil_Leucovorin-Calcium_Oxaliplatin_PTK787_ZK-222584"                                                                                                         
[34481] "Geldanamycin-Analogue_Imatinib-Mesylate"                                                                                                                              
[34482] "Gemcitabine_Triapine"                                                                                                                                                 
[34483] "gp100-Antigen_Incomplete-Freund_s-Adjuvant_Interleukin-12_MART-1-Antigen_Tyrosinase-Peptide"                                                                          
[34484] "gp100-Antigen_Incomplete-Freund_s-Adjuvant_Interleukin-2_MART-1-Antigen_Tyrosinase-Peptide"                                                                           
[34485] "gp100-Antigen_Incomplete-Freund_s-Adjuvant_MART-1-Antigen_Sargramostim_Tyrosinase-Peptide"                                                                            
[34486] "gp100-Antigen_Melan-A_NA17-A-Antigen_Tyrosinase-Peptide"                                                                                                              
[34487] "Interleukin-2_p53-Peptide-Vaccine"                                                                                                                                    
[34488] "ABT-510_Carboplatin_Paclitaxel"                                                                                                                                       
[34489] "AG-858_Imatinib-Mesylate"                                                                                                                                             
[34490] "ALVAC-CEA-B7-1-Vaccine_Tetanus-Toxoid"                                                                                                                                
[34491] "AN-9_Docetaxel"                                                                                                                                                       
[34492] "BCG_NY-ESO-1-Peptide-Vaccine"                                                                                                                                         
[34493] "CC-5013_Dexamethasone"                                                                                                                                                
[34494] "CCI-779_Interferon-Alfa"                                                                                                                                              
[34495] "CCI-779_Letrozole"                                                                                                                                                    
[34496] "CpG-7909_Dacarbazine"                                                                                                                                                 
[34497] "DHA-Paclitaxel_Gemcitabine"                                                                                                                                           
[34498] "E7070_Irinotecan"                                                                                                                                                     
[34499] "EP-2101_Montanide-ISA-51"                                                                                                                                             
[34500] "GW572016_Letrozole"                                                                                                                                                   
[34501] "IDEC-114-Monoclonal-Antibody_Rituximab"                                                                                                                               
[34502] "Montanide-ISA-51_NY-ESO-1-Peptide-Vaccine"                                                                                                                            
[34503] "Montanide-ISA-51_Multi-Epitope-Melanoma-Peptide-Vaccine_Sargramostim"                                                                                                 
[34504] "Montanide-ISA-51_Multi-Epitope-Melanoma-Peptide-Vaccine_Sargramostim_Tetanus-Peptide-Melanoma-Vaccine"                                                                
[34505] "PEG-Interferon-Alfa-2b_Thalidomide"                                                                                                                                   
[34506] "Adenovirus-5-Tumor-Necrosis-Factor-Alpha_Capecitabine"                                                                                                                
[34507] "Adenovirus-L523S-Vaccine_L523S-DNA-Vaccine"                                                                                                                           
[34508] "Adenovirus_Interleukin-12-Gene"                                                                                                                                       
[34509] "Alemtuzumab_Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Vincristine"                                                                                            
[34510] "Alemtuzumab_Fludarabine"                                                                                                                                              
[34511] "Allogeneic-Lymphocytes_MOv-Gamma-Chimeric-Receptor-Gene"                                                                                                              
[34512] "Allogeneic-Lymphocytes_Cyclosporine"                                                                                                                                  
[34513] "Allogeneic-Lymphocytes_Cyclosporine_Sirolimus"                                                                                                                        
[34514] "Allogeneic-Lymphocytes_Interleukin-2_MOv-Gamma-Chimeric-Receptor-Gene"                                                                                                
[34515] "Amoxicillin-Clavulanate-Potassium_Ciprofloxacin"                                                                                                                      
[34516] "Amsacrine_Azacitidine_Etoposide"                                                                                                                                      
[34517] "Anastrozole_Celecoxib"                                                                                                                                                
[34518] "Anastrozole_Fulvestrant"                                                                                                                                              
[34519] "Anastrozole_Gefitinib"                                                                                                                                                
[34520] "Anti-Cytotoxic-T-Lymphocyte-Associated-Antigen-4-Monoclonal-Antibody_Interleukin-2"                                                                                   
[34521] "Anti-Cytotoxic-T-Lymphocyte-Associated-Antigen-4-Monoclonal-Antibody_Sargramostim"                                                                                    
[34522] "Anti-Thymocyte-Globulin_Busulfan_Cyclophosphamide"                                                                                                                    
[34523] "Anti-Thymocyte-Globulin_Busulfan_Cyclophosphamide_Methylprednisolone"                                                                                                 
[34524] "Anti-Thymocyte-Globulin_Busulfan_Melphalan_Methylprednisolone"                                                                                                        
[34525] "Anti-Thymocyte-Globulin_Methotrexate_Mycophenolate-Mofetil_Tacrolimus"                                                                                                
[34526] "Arsenic-Trioxide_Imatinib-Mesylate"                                                                                                                                   
[34527] "Asparaginase_Cyclophosphamide_Cytarabine_Methotrexate_Thioguanine_Vincristine"                                                                                        
[34528] "Asparaginase_Daunorubicin_Methotrexate_Nelarabine_Prednisone_Vincristine"                                                                                             
[34529] "Autologous-Dendritic-Cells_CD40-Ligand"                                                                                                                               
[34530] "Autologous-Dendritic-Cells_Carcinoembryonic-Antigen-Peptide-1-6D_CMV-Pp65-Peptide"                                                                                    
[34531] "Autologous-Dendritic-Cells_Fowlpox-CEA-TRICOM-Vaccine"                                                                                                                
[34532] "Autologous-Dendritic-Cells_Indinavir"                                                                                                                                 
[34533] "Autologous-Dendritic-Cells_Tetanus-Toxoid"                                                                                                                            
[34534] "Autologous-Immunoglobulin-Idiotype-KLH-Conjugate-Vaccine_Sargramostim"                                                                                                
[34535] "Autologous-Lymphocytes_Fludarabine"                                                                                                                                   
[34536] "Autologous-Lymphocytes_Fluorouracil_Interferon-Alfa_Sargramostim"                                                                                                     
[34537] "Autologous-Tumor-Cell-Vaccine_CD40-Ligand_Interleukin-2-Gene"                                                                                                         
[34538] "Azacitidine_Carboplatin"                                                                                                                                              
[34539] "Azacitidine_Cyclophosphamide_Cytarabine_Thioguanine_Vincristine"                                                                                                      
[34540] "Azacitidine_Cytarabine_Daunorubicin_Prednisone_Vincristine"                                                                                                           
[34541] "Azacitidine_Etoposide"                                                                                                                                                
[34542] "Beclomethasone_Methylprednisolone"                                                                                                                                    
[34543] "Beclomethasone_Prednisone"                                                                                                                                            
[34544] "Bevacizumab_PEG-Interferon-Alfa-2b"                                                                                                                                   
[34545] "Bevacizumab_Capecitabine_Oxaliplatin"                                                                                                                                 
[34546] "Bevacizumab_Cetuximab"                                                                                                                                                
[34547] "Bevacizumab_Cetuximab_Irinotecan"                                                                                                                                     
[34548] "Bevacizumab_Cyclophosphamide"                                                                                                                                         
[34549] "Bevacizumab_Doxorubicin"                                                                                                                                              
[34550] "Bevacizumab_Erlotinib"                                                                                                                                                
[34551] "Bevacizumab_Fluorouracil"                                                                                                                                             
[34552] "Bevacizumab_Imatinib-Mesylate"                                                                                                                                        
[34553] "Bicalutamide_Triptorelin"                                                                                                                                             
[34554] "Bleomycin_Cyclophosphamide_Doxorubicin_Methotrexate_Prednisone_Rituximab_Vincristine"                                                                                 
[34555] "Bleomycin_Cyclophosphamide_Etoposide_Mitoxantrone_Prednisolone_Rituximab_Vincristine"                                                                                 
[34556] "Boronophenylalanine-Fructose-Complex_Sodium-Borocaptate"                                                                                                              
[34557] "Bortezomib_Carboplatin"                                                                                                                                               
[34558] "Bortezomib_Carboplatin_Etoposide"                                                                                                                                     
[34559] "Bortezomib_Carboplatin_Gemcitabine"                                                                                                                                   
[34560] "Bortezomib_Carboplatin_Paclitaxel"                                                                                                                                    
[34561] "Bortezomib_Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Vincristine"                                                                                             
[34562] "Bortezomib_Dexamethasone"                                                                                                                                             
[34563] "Bortezomib_Docetaxel"                                                                                                                                                 
[34564] "Bortezomib_Doxorubicin"                                                                                                                                               
[34565] "Bortezomib_Fludarabine"                                                                                                                                               
[34566] "Bortezomib_Fluorouracil_Leucovorin-Calcium"                                                                                                                           
[34567] "Bortezomib_Gemcitabine"                                                                                                                                               
[34568] "Bortezomib_Irinotecan"                                                                                                                                                
[34569] "Bortezomib_Mitoxantrone"                                                                                                                                              
[34570] "Bortezomib_Oxaliplatin"                                                                                                                                               
[34571] "Bortezomib_Paclitaxel"                                                                                                                                                
[34572] "Bortezomib_Topotecan"                                                                                                                                                 
[34573] "Calcitriol_Zoledronate"                                                                                                                                               
[34574] "Calcium-Carbonate_Cholecalciferol_Conjugated-Estrogens"                                                                                                               
[34575] "Calcium-Carbonate_Cholecalciferol_Conjugated-Estrogens_Risedronate"                                                                                                   
[34576] "Calcium-Carbonate_Cholecalciferol_Risedronate"                                                                                                                        
[34577] "Capecitabine_DJ-927"                                                                                                                                                  
[34578] "Capecitabine_GTI-2040"                                                                                                                                                
[34579] "Capecitabine_LY317615"                                                                                                                                                
[34580] "Capecitabine_Celecoxib_Gefitinib"                                                                                                                                     
[34581] "Capecitabine_Celecoxib_Irinotecan"                                                                                                                                    
[34582] "Capecitabine_Docetaxel_Tipifarnib"                                                                                                                                    
[34583] "Capecitabine_Fluorouracil_Leucovorin-Calcium_Oxaliplatin"                                                                                                             
[34584] "Capecitabine_Ixabepilone"                                                                                                                                             
[34585] "Capecitabine_Tipifarnib"                                                                                                                                              
[34586] "Captopril_Tissue-Plasminogen-Activator"                                                                                                                               
[34587] "Carboplatin_Celecoxib_Gemcitabine"                                                                                                                                    
[34588] "Carboplatin_Celecoxib_Gemcitabine_Zileuton"                                                                                                                           
[34589] "Carboplatin_Celecoxib_Paclitaxel"                                                                                                                                     
[34590] "Carboplatin_Cetuximab_Paclitaxel"                                                                                                                                     
[34591] "Carboplatin_Cyclophosphamide_Cytarabine_Etoposide-Phosphate_Rituximab_Sodium-Thiosulfate"                                                                             
[34592] "Carboplatin_Cyclophosphamide_Cytarabine_Etoposide_Rituximab_Sodium-Thiosulfate"                                                                                       
[34593] "Carboplatin_Cyclophosphamide_Doxorubicin_Etoposide"                                                                                                                   
[34594] "Carboplatin_Cyclophosphamide_Etoposide-Phosphate"                                                                                                                     
[34595] "Carboplatin_Cyclophosphamide_Etoposide-Phosphate_Sodium-Thiosulfate"                                                                                                  
[34596] "Carboplatin_Cyclophosphamide_Etoposide_Sodium-Thiosulfate"                                                                                                            
[34597] "Carboplatin_Cytarabine_Etoposide_Ifosfamide_Methotrexate_Rituximab"                                                                                                   
[34598] "Carboplatin_Dexamethasone_Gemcitabine"                                                                                                                                
[34599] "Carboplatin_Dexamethasone_Gemcitabine_Rituximab"                                                                                                                      
[34600] "Carboplatin_Etoposide_Filgrastim"                                                                                                                                     
[34601] "Carboplatin_Etoposide_Thalidomide"                                                                                                                                    
[34602] "Carboplatin_Fludarabine_Thalidomide_Topotecan"                                                                                                                        
[34603] "Carboplatin_Fluorouracil_Leucovorin-Calcium"                                                                                                                          
[34604] "Carboplatin_Gefitinib_Paclitaxel"                                                                                                                                     
[34605] "Carboplatin_Gemcitabine_Zileuton"                                                                                                                                     
[34606] "Carboplatin_Irinotecan_Vincristine"                                                                                                                                   
[34607] "Carboplatin_Ixabepilone"                                                                                                                                              
[34608] "Carboplatin_Ixabepilone_Trastuzumab"                                                                                                                                  
[34609] "Carboplatin_Lobradimil"                                                                                                                                               
[34610] "Carboplatin_Monoclonal-Antibody-ABX-EGF_Paclitaxel"                                                                                                                   
[34611] "Carboplatin_Oblimersen_Paclitaxel"                                                                                                                                    
[34612] "Carboplatin_Paclitaxel_Prinomastat"                                                                                                                                   
[34613] "Carboplatin_Paclitaxel_Trastuzumab"                                                                                                                                   
[34614] "Carboplatin_Pemetrexed-Disodium"                                                                                                                                      
[34615] "Carboplatin_Polyglutamate-Paclitaxel"                                                                                                                                 
[34616] "Carcinoembryonic-Antigen-Peptide-1-6D_Montanide-ISA-51"                                                                                                               
[34617] "Carcinoembryonic-Antigen-Peptide-1-6D_Sargramostim"                                                                                                                   
[34618] "Carmustine_Efaproxiral"                                                                                                                                               
[34619] "Celecoxib_Cyclophosphamide_Doxorubicin_Etoposide_Ifosfamide_Vinblastine_Vincristine"                                                                                  
[34620] "Celecoxib_Cyclophosphamide_Etoposide_Thalidomide"                                                                                                                     
[34621] "Celecoxib_Docetaxel_Irinotecan"                                                                                                                                       
[34622] "Celecoxib_Epirubicin"                                                                                                                                                 
[34623] "Celecoxib_Erlotinib"                                                                                                                                                  
[34624] "Celecoxib_Exemestane"                                                                                                                                                 
[34625] "Celecoxib_Fluorouracil_Irinotecan_Leucovorin-Calcium"                                                                                                                 
[34626] "Celecoxib_Fluorouracil_Leucovorin-Calcium"                                                                                                                            
[34627] "Celecoxib_Fluorouracil_Leucovorin-Calcium_Oxaliplatin"                                                                                                                
[34628] "Celecoxib_Gefitinib"                                                                                                                                                  
[34629] "Celecoxib_Gemcitabine"                                                                                                                                                
[34630] "Celecoxib_Temozolomide_Thalidomide"                                                                                                                                   
[34631] "Celecoxib_Vinorelbine"                                                                                                                                                
[34632] "Cetuximab_Cisplatin"                                                                                                                                                  
[34633] "Cetuximab_Docetaxel_Irinotecan"                                                                                                                                       
[34634] "Cetuximab_Doxorubicin"                                                                                                                                                
[34635] "Cetuximab_Fluorouracil_Leucovorin-Calcium_Oxaliplatin"                                                                                                                
[34636] "Cetuximab_Paclitaxel"                                                                                                                                                 
[34637] "Cisplatin_S-1"                                                                                                                                                        
[34638] "Cisplatin_Cytarabine_Methylprednisolone_Pixantrone"                                                                                                                   
[34639] "Cisplatin_Cytarabine_Methylprednisolone_Pixantrone_Rituximab"                                                                                                         
[34640] "Cisplatin_Dimesna_Docetaxel"                                                                                                                                          
[34641] "Cisplatin_Doxorubicin_Methotrexate_Muramyl-Tripeptide-Phosphatidylethanolamine-Liposome"                                                                              
[34642] "Cisplatin_Edotecarin"                                                                                                                                                 
[34643] "Cisplatin_Erlotinib_Etoposide"                                                                                                                                        
[34644] "Cisplatin_Etoposide_Irinotecan"                                                                                                                                       
[34645] "Cisplatin_Etoposide_Monoclonal-Antibody-11D10-Anti-Idiotype-Vaccine_Monoclonal-Antibody-GD2-Anti-Idiotype-Vaccine"                                                    
[34646] "Cisplatin_Etoposide_Topotecan"                                                                                                                                        
[34647] "Cisplatin_Filgrastim_Fluorouracil_Paclitaxel"                                                                                                                         
[34648] "Cisplatin_Flavopiridol_Irinotecan"                                                                                                                                    
[34649] "Cisplatin_Fluorouracil_Irinotecan_Leucovorin-Calcium"                                                                                                                 
[34650] "Cisplatin_Fluorouracil_Oblimersen"                                                                                                                                    
[34651] "Cisplatin_Fluorouracil_Paclitaxel_Pegfilgrastim"                                                                                                                      
[34652] "Cisplatin_Gefitinib"                                                                                                                                                  
[34653] "Cisplatin_Gefitinib_Gemcitabine"                                                                                                                                      
[34654] "Cisplatin_Gemcitabine_ISIS-3521"                                                                                                                                      
[34655] "Cisplatin_Gemcitabine_LY293111"                                                                                                                                       
[34656] "Cisplatin_Gemcitabine_Tipifarnib"                                                                                                                                     
[34657] "Cisplatin_Ifosfamide_Muramyl-Tripeptide-Phosphatidylethanolamine-Liposome"                                                                                            
[34658] "Cisplatin_Imatinib-Mesylate_Irinotecan"                                                                                                                               
[34659] "Cisplatin_Ixabepilone"                                                                                                                                                
[34660] "Cisplatin_Pemetrexed-Disodium"                                                                                                                                        
[34661] "Cladribine_Rituximab"                                                                                                                                                 
[34662] "Clofarabine_Cytarabine"                                                                                                                                               
[34663] "Clofarabine_Cytarabine_Idarubicin"                                                                                                                                    
[34664] "Clofarabine_Idarubicin"                                                                                                                                               
[34665] "Coenzyme-Q10_Vitamin-E"                                                                                                                                               
[34666] "Cyclophosphamide_Cyclosporine_Fludarabine_Methylprednisolone_Thiotepa"                                                                                                
[34667] "Cyclophosphamide_Cytarabine_Daunorubicin_Dexamethasone_Leucovorin-Calcium_Mercaptopurine_Methotrexate_Pegaspargase_Thioguanine_Vincristine"                           
[34668] "Cyclophosphamide_Cytarabine_Dexamethasone_Etoposide-Phosphate_Methotrexate"                                                                                           
[34669] "Cyclophosphamide_Dactinomycin_Irinotecan_Vincristine"                                                                                                                 
[34670] "Cyclophosphamide_Decitabine_Doxorubicin"                                                                                                                              
[34671] "Cyclophosphamide_Docetaxel"                                                                                                                                           
[34672] "Cyclophosphamide_Doxorubicin_Epratuzumab_Prednisone_Rituximab_Vincristine"                                                                                            
[34673] "Cyclophosphamide_Doxorubicin_Etoposide_Fludarabine_Prednisone_Rituximab_Vincristine"                                                                                  
[34674] "Cyclophosphamide_Doxorubicin_Leucovorin-Calcium_Methotrexate_Methylprednisolone_Rituximab_Vincristine"                                                                
[34675] "Cyclophosphamide_Doxorubicin_Leucovorin-Calcium_Methotrexate_Methylprednisolone_Vincristine"                                                                          
[34676] "Cyclophosphamide_Doxorubicin_Oblimersen_Prednisone_Rituximab_Vincristine"                                                                                             
[34677] "Cyclophosphamide_Doxorubicin_Pegfilgrastim"                                                                                                                           
[34678] "Cyclophosphamide_Doxorubicin_Prednisolone_Rituximab_Vincristine"                                                                                                      
[34679] "Cyclophosphamide_Doxorubicin_Tipifarnib"                                                                                                                              
[34680] "Cyclophosphamide_Doxorubicin_Trastuzumab"                                                                                                                             
[34681] "Cyclophosphamide_Epirubicin_Trastuzumab"                                                                                                                              
[34682] "Cyclophosphamide_Etoposide_Imatinib-Mesylate"                                                                                                                         
[34683] "Cyclophosphamide_Etoposide_Imatinib-Mesylate_Leucovorin-Calcium_Methotrexate"                                                                                         
[34684] "Cyclophosphamide_Etoposide_Iodine-I-131-Tositumomab"                                                                                                                  
[34685] "Cyclophosphamide_Etoposide_Leucovorin-Calcium_Methotrexate"                                                                                                           
[34686] "Cyclophosphamide_Etoposide_Prednisone"                                                                                                                                
[34687] "Cyclophosphamide_Filgrastim_Rituximab"                                                                                                                                
[34688] "Cyclophosphamide_Fludarabine_Melphalan"                                                                                                                               
[34689] "Cyclophosphamide_Fludarabine_Rituximab"                                                                                                                               
[34690] "Cyclophosphamide_Methylprednisolone_Rasburicase_Vincristine"                                                                                                          
[34691] "Cyclophosphamide_Methylprednisolone_Rituximab"                                                                                                                        
[34692] "Cyclophosphamide_Oblimersen"                                                                                                                                          
[34693] "Cyclophosphamide_Prednisone_Rasburicase_Vincristine"                                                                                                                  
[34694] "Cyclophosphamide_Prednisone_Rituximab"                                                                                                                                
[34695] "Cyclosporine_Sirolimus"                                                                                                                                               
[34696] "Cyproterone_Leuprolide"                                                                                                                                               
[34697] "Cyproterone_Triptorelin"                                                                                                                                              
[34698] "Cytarabine_EL625_Idarubicin"                                                                                                                                          
[34699] "Cytarabine_GTI-2040"                                                                                                                                                  
[34700] "Cytarabine_VNP40101M"                                                                                                                                                 
[34701] "Cytarabine_Daunorubicin_Dexamethasone_Methotrexate_Pegaspargase_Vincristine"                                                                                          
[34702] "Cytarabine_Daunorubicin_Etoposide_Gemtuzumab-Ozogamicin"                                                                                                              
[34703] "Cytarabine_Daunorubicin_Methotrexate_Pegaspargase_Prednisone_Vincristine"                                                                                             
[34704] "Cytarabine_Daunorubicin_Zosuquidar-Trihydrochloride"                                                                                                                  
[34705] "Cytarabine_Dexamethasone_Lomustine_Methotrexate_Procarbazine"                                                                                                         
[34706] "Cytarabine_Etoposide_Gemtuzumab-Ozogamicin_Idarubicin"                                                                                                                
[34707] "Cytarabine_Etoposide_Methotrexate_Rituximab"                                                                                                                          
[34708] "Cytarabine_Flavopiridol_Mitoxantrone"                                                                                                                                 
[34709] "Cytarabine_Gemtuzumab-Ozogamicin_Idarubicin"                                                                                                                          
[34710] "Cytarabine_Irinotecan"                                                                                                                                                
[34711] "Cytarabine_Leucovorin-Calcium_Methotrexate"                                                                                                                           
[34712] "Cytarabine_Oblimersen"                                                                                                                                                
[34713] "Cytochlor_Tetrahydrouridine"                                                                                                                                          
[34714] "Dacarbazine_Interleukin-2_Temozolomide"                                                                                                                               
[34715] "Dacarbazine_Monoclonal-Antibody-Anti-Anb3-Integrin"                                                                                                                   
[34716] "Dacarbazine_Temozolomide"                                                                                                                                             
[34717] "Daclizumab_Interleukin-2"                                                                                                                                             
[34718] "Daclizumab_Methylprednisolone"                                                                                                                                        
[34719] "Daunorubicin_Dexamethasone_Pegaspargase_Vincristine"                                                                                                                  
[34720] "Decitabine_Imatinib-Mesylate"                                                                                                                                         
[34721] "Decitabine_Valproic-Acid"                                                                                                                                             
[34722] "Dexamethasone_Doxorubicin_Thalidomide_Vincristine"                                                                                                                    
[34723] "Dexamethasone_Epoetin-Alfa"                                                                                                                                           
[34724] "Dexamethasone_Fludarabine_Pixantrone_Rituximab"                                                                                                                       
[34725] "Dexamethasone_Idarubicin_Imatinib-Mesylate_Pegaspargase_Vincristine"                                                                                                  
[34726] "Dexamethasone_Idarubicin_Pegaspargase_Vincristine"                                                                                                                    
[34727] "Dexamethasone_Oblimersen_Thalidomide"                                                                                                                                 
[34728] "Docetaxel_DN-101"                                                                                                                                                     
[34729] "Docetaxel_GTI-2040"                                                                                                                                                   
[34730] "Docetaxel_TLK286"                                                                                                                                                     
[34731] "Docetaxel_ZD6474"                                                                                                                                                     
[34732] "Docetaxel_Doxorubicin_Oblimersen"                                                                                                                                     
[34733] "Docetaxel_Epirubicin_Pegfilgrastim"                                                                                                                                   
[34734] "Docetaxel_Erlotinib"                                                                                                                                                  
[34735] "Docetaxel_Estramustine_Exisulind"                                                                                                                                     
[34736] "Docetaxel_Fowlpox-PSA-Vaccine"                                                                                                                                        
[34737] "Docetaxel_Fowlpox-PSA-Vaccine_Sargramostim"                                                                                                                           
[34738] "Docetaxel_Gefitinib"                                                                                                                                                  
[34739] "Docetaxel_Leuprolide_Testosterone"                                                                                                                                    
[34740] "Docetaxel_Suramin"                                                                                                                                                    
[34741] "Docetaxel_Tariquidar"                                                                                                                                                 
[34742] "Doxorubicin_Etoposide_Mitotane_Tariquidar_Vincristine"                                                                                                                
[34743] "Doxorubicin_Ifosfamide_Methotrexate_Muramyl-Tripeptide-Phosphatidylethanolamine-Liposome"                                                                             
[34744] "Doxorubicin_Imatinib-Mesylate_Pegaspargase_Prednisone_Vincristine"                                                                                                    
[34745] "Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vinblastine"                                                                                                       
[34746] "Doxorubicin_Oblimersen"                                                                                                                                               
[34747] "Doxorubicin_Ranpirnase"                                                                                                                                               
[34748] "Edrecolomab_Fluorouracil_Leucovorin-Calcium"                                                                                                                          
[34749] "Edrecolomab_Fluorouracil_Levamisole"                                                                                                                                  
[34750] "Edrecolomab_Sargramostim"                                                                                                                                             
[34751] "Eniluracil_Fluorouracil"                                                                                                                                              
[34752] "Eniluracil_Fluorouracil_Leucovorin-Calcium"                                                                                                                           
[34753] "Epirubicin_Rituximab"                                                                                                                                                 
[34754] "Epirubicin_Thalidomide"                                                                                                                                               
[34755] "Epoetin-Alfa_Thalidomide"                                                                                                                                             
[34756] "Epratuzumab_Rituximab"                                                                                                                                                
[34757] "Erlotinib_Fluorouracil_Leucovorin-Calcium_Oxaliplatin"                                                                                                                
[34758] "Erlotinib_Irinotecan"                                                                                                                                                 
[34759] "Erlotinib_Paclitaxel_Trastuzumab"                                                                                                                                     
[34760] "Erlotinib_Temozolomide"                                                                                                                                               
[34761] "Estradiol_Zoledronate"                                                                                                                                                
[34762] "Estramustine_Ixabepilone"                                                                                                                                             
[34763] "Etoposide_Monoclonal-Antibody-3F8"                                                                                                                                    
[34764] "Etoposide_Satraplatin"                                                                                                                                                
[34765] "Exemestane_Trastuzumab"                                                                                                                                               
[34766] "Exemestane_Triptorelin"                                                                                                                                               
[34767] "Filgrastim_Monoclonal-Antibody-Hu1D10"                                                                                                                                
[34768] "Flavopiridol_Fludarabine_Rituximab"                                                                                                                                   
[34769] "Flavopiridol_Fluorouracil_Irinotecan_Leucovorin-Calcium"                                                                                                              
[34770] "Flavopiridol_Fluorouracil_Leucovorin-Calcium"                                                                                                                         
[34771] "Flavopiridol_Imatinib-Mesylate"                                                                                                                                       
[34772] "Floxuridine_Irinotecan"                                                                                                                                               
[34773] "Fluorouracil_Virulizin"                                                                                                                                               
[34774] "Fluorouracil_Gefitinib_Irinotecan_Leucovorin-Calcium"                                                                                                                 
[34775] "Fluorouracil_Gefitinib_Leucovorin-Calcium_Oxaliplatin"                                                                                                                
[34776] "Fluorouracil_Irinotecan_Leucovorin-Calcium_Monoclonal-Antibody-ABX-EGF"                                                                                               
[34777] "Fluorouracil_Leucovorin-Calcium_UCN-01"                                                                                                                               
[34778] "Fluorouracil_Leucovorin-Calcium_Lonafarnib"                                                                                                                           
[34779] "Fluorouracil_Leucovorin-Calcium_Oblimersen_Oxaliplatin"                                                                                                               
[34780] "Fluorouracil_Leucovorin-Calcium_Oxaliplatin_ZD6126"                                                                                                                   
[34781] "Fowlpox-CEA-TRICOM-Vaccine_Fowlpox-Sargramostim-Vaccine"                                                                                                              
[34782] "Fowlpox-PSA-Vaccine_Sargramostim"                                                                                                                                     
[34783] "Fowlpox-PSA-TRICOM-Vaccine_Fowlpox-Sargramostim-Vaccine_Vaccinia-Prostate-Specific-Antigen-TRICOM-Vaccine"                                                            
[34784] "Fowlpox-PSA-TRICOM-Vaccine_Sargramostim_Vaccinia-Prostate-Specific-Antigen-TRICOM-Vaccine"                                                                            
[34785] "Fowlpox-PSA-TRICOM-Vaccine_Vaccinia-Prostate-Specific-Antigen-TRICOM-Vaccine"                                                                                         
[34786] "Fowlpox-Sargramostim-Vaccine_Fowlpox-TRICOM-Vaccine"                                                                                                                  
[34787] "Fowlpox-Tyrosinase-Vaccine_Interleukin-2_Vaccinia-Tyrosinase-Vaccine"                                                                                                 
[34788] "Fulvestrant_Gefitinib"                                                                                                                                                
[34789] "Gefitinib_Oxaliplatin"                                                                                                                                                
[34790] "Gefitinib_Tamoxifen"                                                                                                                                                  
[34791] "Gefitinib_Temozolomide"                                                                                                                                               
[34792] "Gefitinib_Trastuzumab"                                                                                                                                                
[34793] "Gemcitabine_Virulizin"                                                                                                                                                
[34794] "Gemcitabine_Ixabepilone"                                                                                                                                              
[34795] "Gemcitabine_Lonafarnib"                                                                                                                                               
[34796] "Gemcitabine_Mistletoe"                                                                                                                                                
[34797] "Gemcitabine_Oblimersen"                                                                                                                                               
[34798] "Gemcitabine_Soblidotin"                                                                                                                                               
[34799] "Gemcitabine_Suramin"                                                                                                                                                  
[34800] "Gemcitabine_Tipifarnib"                                                                                                                                               
[34801] "Gemcitabine_Trastuzumab"                                                                                                                                              
[34802] "Gusperimus_Monoclonal-Antibody-L6"                                                                                                                                    
[34803] "Imatinib-Mesylate_PEG-Interferon-Alfa-2a"                                                                                                                             
[34804] "Imatinib-Mesylate_Oblimersen"                                                                                                                                         
[34805] "Incomplete-Freund_s-Adjuvant_MART-1-Antigen"                                                                                                                          
[34806] "Incomplete-Freund_s-Adjuvant_Interleukin-12_Tyrosinase-Related-Protein-1"                                                                                             
[34807] "Incomplete-Freund_s-Adjuvant_Interleukin-2_Tyrosinase-Related-Protein-1"                                                                                              
[34808] "Incomplete-Freund_s-Adjuvant_Peptide-946-Melanoma-Vaccine_Tetanus-Peptide-Melanoma-Vaccine"                                                                           
[34809] "Incomplete-Freund_s-Adjuvant_Sargramostim_Tyrosinase-Related-Protein-1"                                                                                               
[34810] "Interferon-Alfa_Oblimersen"                                                                                                                                           
[34811] "Interferon-Gamma_Voriconazole"                                                                                                                                        
[34812] "Interleukin-12_Montanide_ISA-51_Tyrosinase-Related_Protein-1"                                                                                                         
[34813] "Interleukin-12_Paclitaxel"                                                                                                                                            
[34814] "Irinotecan_Pemetrexed-Disodium"                                                                                                                                       
[34815] "Letrozole_Tipifarnib"                                                                                                                                                 
[34816] "Leucovorin-Calcium_Mercaptopurine_Methotrexate_Vincristine"                                                                                                           
[34817] "Lomustine_Temozolomide_Thalidomide"                                                                                                                                   
[34818] "Lonafarnib_Paclitaxel_Trastuzumab"                                                                                                                                    
[34819] "Marijuana_Morphine"                                                                                                                                                   
[34820] "Melanoma-Helper-Peptide-Vaccine_Montanide-ISA-51_Multi-Epitope-Melanoma-Peptide-Vaccine_Sargramostim"                                                                 
[34821] "Melanoma-Helper-Peptide-Vaccine_Montanide-ISA-51_Sargramostim"                                                                                                        
[34822] "Mercaptopurine_Methotrexate_Nelarabine"                                                                                                                               
[34823] "Methotrexate_Mycophenolate-Mofetil_Tacrolimus"                                                                                                                        
[34824] "Methotrexate_Procarbazine_Rituximab_Vincristine"                                                                                                                      
[34825] "Methotrexate_Rituximab_Temozolomide"                                                                                                                                  
[34826] "Methotrexate_Thiotepa"                                                                                                                                                
[34827] "Methylprednisolone_Mycophenolate-Mofetil_Tacrolimus"                                                                                                                  
[34828] "Mitoxantrone_Prednisone_YM598"                                                                                                                                        
[34829] "Mitoxantrone_Prednisone_Prinomastat"                                                                                                                                  
[34830] "Monoclonal-Antibody-11D10-Anti-Idiotype-Vaccine_Monoclonal-Antibody-GD2-Anti-Idiotype-Vaccine"                                                                        
[34831] "Multivitamins_Soy-Protein-Isolate"                                                                                                                                    
[34832] "Nilutamide_Triptorelin"                                                                                                                                               
[34833] "Nolatrexed-Dihydrochloride_Cisplatin"                                                                                                                                 
[34834] "Oblimersen_Rituximab"                                                                                                                                                 
[34835] "Paclitaxel_Pegfilgrastim"                                                                                                                                             
[34836] "Paclitaxel_Suramin"                                                                                                                                                   
[34837] "Paclitaxel_Trastuzumab"                                                                                                                                               
[34838] "Patent-Blue-V-Dye_Technetium-Tc-99m-Sulfur-Colloid"                                                                                                                   
[34839] "Pixantrone_Rituximab"                                                                                                                                                 
[34840] "Prednisone_UCN-01"                                                                                                                                                    
[34841] "Prednisone_Satraplatin"                                                                                                                                               
[34842] "Rv-B7-1-Vaccine_Sargramostim_Vaccinia-Prostate-Specific-Antigen-Vaccine"                                                                                              
[34843] "Ranpirnase_Tamoxifen"                                                                                                                                                 
[34844] "Rifampin_Tetracycline"                                                                                                                                                
[34845] "Sargramostim_Telomerase_540-548-Peptide-Vaccine"                                                                                                                      
[34846] "Sargramostim_Vaccinia-CEA-TRICOM-Vaccine"                                                                                                                             
[34847] "Sargramostim_Vaccinia-MUC-1-Vaccine_Vaccinia-TRICOM-Vaccine"                                                                                                          
[34848] "Selenium_Soy-Protein-Isolate_Vitamin-E"                                                                                                                               
[34849] "Sulindac_Tamoxifen"                                                                                                                                                   
[34850] "Tamoxifen_Tipifarnib"                                                                                                                                                 
[34851] "Tamoxifen_Triptorelin"                                                                                                                                                
[34852] "Tipifarnib_Topotecan"                                                                                                                                                 
[34853] "Tipifarnib_Trastuzumab"                                                                                                                                               
[34854] "Topotecan_UCN-01"                                                                                                                                                     
[34855] "Vaccinia-MUC-1-Vaccine_Vaccinia-TRICOM-Vaccine"                                                                                                                       
[34856] "Vinorelbine_Zosuquidar-Trihydrochloride"                                                                                                                              
[34857] "Autoimmune_Lymphoproliferative_Syndrome"                                                                                                                              
[34858] "Trisomy_17"                                                                                                                                                           
[34859] "Trisomy_16"                                                                                                                                                           
[34860] "Tetrasomy_7"                                                                                                                                                          
[34861] "Tetrasomy_17"                                                                                                                                                         
[34862] "Gray_Zone_Lymphoma"                                                                                                                                                   
[34863] "Mediastinal_Gray_Zone_Lymphoma"                                                                                                                                       
[34864] "Pityriasis_Lichenoides_et_Varioliformis_Acuta"                                                                                                                        
[34865] "Renal_Cell_Carcinoma_with_t_X_1_p11_q21"                                                                                                                              
[34866] "t_X_1_p11_q21"                                                                                                                                                        
[34867] "Renal_Cell_Carcinoma_with_t_X_1_p11_p34"                                                                                                                              
[34868] "t_X_1_p11_p34"                                                                                                                                                        
[34869] "Renal_Cell_Carcinoma_with_t_X_17_p11_q25"                                                                                                                             
[34870] "Renal_Cell_Carcinoma_with_t_X_10_p11_q23"                                                                                                                             
[34871] "t_X_10_p11_q23"                                                                                                                                                       
[34872] "t_8_22_p11_q11"                                                                                                                                                       
[34873] "BCR-FGFR1_Fusion_Protein_Expression"                                                                                                                                  
[34874] "t_4_22_q12_q11"                                                                                                                                                       
[34875] "BCR-PDGFRA_Fusion_Protein_Expression"                                                                                                                                 
[34876] "TEL-ABL_Fusion_Protein_Expression"                                                                                                                                    
[34877] "t_9_12_q34_p13"                                                                                                                                                       
[34878] "TEL-JAK2_Fusion_Protein_Expression"                                                                                                                                   
[34879] "t_9_12_p24_p13"                                                                                                                                                       
[34880] "BCR-JAK2_Fusion_Protein_Expression"                                                                                                                                   
[34881] "Lysis"                                                                                                                                                                
[34882] "t_9_22_p24_q11"                                                                                                                                                       
[34883] "Cytotoxic"                                                                                                                                                            
[34884] "Measurable"                                                                                                                                                           
[34885] "Residual"                                                                                                                                                             
[34886] "Informed"                                                                                                                                                             
[34887] "Proliferation"                                                                                                                                                        
[34888] "_17-Allylamino_17-demethoxygeldanamycin"                                                                                                                              
[34889] "Provider"                                                                                                                                                             
[34890] "Site"                                                                                                                                                                 
[34891] "Support"                                                                                                                                                              
[34892] "Intestinal_Mass"                                                                                                                                                      
[34893] "Colonic_Mass"                                                                                                                                                         
[34894] "Gain_of_Chromosome_14"                                                                                                                                                
[34895] "Acidosis"                                                                                                                                                             
[34896] "Age-Months"                                                                                                                                                           
[34897] "Age-Years"                                                                                                                                                            
[34898] "Alkalosis"                                                                                                                                                            
[34899] "Allergic"                                                                                                                                                             
[34900] "And"                                                                                                                                                                  
[34901] "Arachnoiditis"                                                                                                                                                        
[34902] "Atrial"                                                                                                                                                               
[34903] "Auditory"                                                                                                                                                             
[34904] "Autoimmune"                                                                                                                                                           
[34905] "Average"                                                                                                                                                              
[34906] "Bicarbonate"                                                                                                                                                          
[34907] "Blur"                                                                                                                                                                 
[34908] "Bradycardia"                                                                                                                                                          
[34909] "Bruising"                                                                                                                                                             
[34910] "Callback"                                                                                                                                                             
[34911] "Cellularity"                                                                                                                                                          
[34912] "Clone"                                                                                                                                                                
[34913] "Cognitive"                                                                                                                                                            
[34914] "Color"                                                                                                                                                                
[34915] "Confusion"                                                                                                                                                            
[34916] "Consciousness"                                                                                                                                                        
[34917] "Constipation"                                                                                                                                                         
[34918] "Constitutional"                                                                                                                                                       
[34919] "Contraception"                                                                                                                                                        
[34920] "Contraindicated"                                                                                                                                                      
[34921] "Corrected"                                                                                                                                                            
[34922] "Cough"                                                                                                                                                                
[34923] "Cranial"                                                                                                                                                              
[34924] "Creatine"                                                                                                                                                             
[34925] "Cushingoid"                                                                                                                                                           
[34926] "Date_Time"                                                                                                                                                            
[34927] "Deficit"                                                                                                                                                              
[34928] "Diplopia"                                                                                                                                                             
[34929] "Distress"                                                                                                                                                             
[34930] "Dizziness"                                                                                                                                                            
[34931] "Earache"                                                                                                                                                              
[34932] "Echocardiogram"                                                                                                                                                       
[34933] "Ejection_Fraction"                                                                                                                                                    
[34934] "Engraftment"                                                                                                                                                          
[34935] "Enrollment"                                                                                                                                                           
[34936] "Entered"                                                                                                                                                              
[34937] "Esophageal"                                                                                                                                                           
[34938] "Feminine"                                                                                                                                                             
[34939] "Flare"                                                                                                                                                                
[34940] "Flatulence"                                                                                                                                                           
[34941] "Floaters"                                                                                                                                                             
[34942] "Gain"                                                                                                                                                                 
[34943] "Geographic"                                                                                                                                                           
[34944] "Germ"                                                                                                                                                                 
[34945] "Gamma-Glutamyl_Transpeptidase"                                                                                                                                        
[34946] "Graph"                                                                                                                                                                
[34947] "Hallucination"                                                                                                                                                        
[34948] "Haptoglobin"                                                                                                                                                          
[34949] "Harvest"                                                                                                                                                              
[34950] "Hematemesis"                                                                                                                                                          
[34951] "Hemolysis"                                                                                                                                                            
[34952] "Hiccough"                                                                                                                                                             
[34953] "Hypercholesterolemia"                                                                                                                                                 
[34954] "Hyperkalemia"                                                                                                                                                         
[34955] "Hypermagnesemia"                                                                                                                                                      
[34956] "Hypernatremia"                                                                                                                                                        
[34957] "Hypertriglyceridemia"                                                                                                                                                 
[34958] "Hypoalbuminemia"                                                                                                                                                      
[34959] "Hypocalcemia"                                                                                                                                                         
[34960] "Hypokalemia"                                                                                                                                                          
[34961] "Hypomagnesemia"                                                                                                                                                       
[34962] "Hyponatremia"                                                                                                                                                         
[34963] "Hypophophatemia"                                                                                                                                                      
[34964] "International_Classification_of_Disease_for_Oncology"                                                                                                                 
[34965] "Ileus"                                                                                                                                                                
[34966] "Inner"                                                                                                                                                                
[34967] "Intubation"                                                                                                                                                           
[34968] "Laboratory"                                                                                                                                                           
[34969] "Libido"                                                                                                                                                               
[34970] "Life"                                                                                                                                                                 
[34971] "Lipase"                                                                                                                                                               
[34972] "Masculine"                                                                                                                                                            
[34973] "Measurement"                                                                                                                                                          
[34974] "Memory"                                                                                                                                                               
[34975] "Mitotic"                                                                                                                                                              
[34976] "Movement"                                                                                                                                                             
[34977] "North_American_Brain_Tumor_Consortium"                                                                                                                                
[34978] "New_Approaches_to_Brain_Tumor_Therapy_Consortium"                                                                                                                     
[34979] "Nyctalopia"                                                                                                                                                           
[34980] "Or"                                                                                                                                                                   
[34981] "Palpitations"                                                                                                                                                         
[34982] "Performed"                                                                                                                                                            
[34983] "Pericardial"                                                                                                                                                          
[34984] "Personality"                                                                                                                                                          
[34985] "Phlebitis"                                                                                                                                                            
[34986] "Photosensitivity"                                                                                                                                                     
[34987] "Pigmentation"                                                                                                                                                         
[34988] "Pneumothorax"                                                                                                                                                         
[34989] "Portal"                                                                                                                                                               
[34990] "Post"                                                                                                                                                                 
[34991] "Postal"                                                                                                                                                               
[34992] "Pre-study"                                                                                                                                                            
[34993] "Proctitis"                                                                                                                                                            
[34994] "Proteinuria"                                                                                                                                                          
[34995] "Range"                                                                                                                                                                
[34996] "Refractory"                                                                                                                                                           
[34997] "Requirement"                                                                                                                                                          
[34998] "Retention"                                                                                                                                                            
[34999] "Salivary"                                                                                                                                                             
[35000] "Shared"                                                                                                                                                               
[35001] "Shortening_Fraction"                                                                                                                                                  
[35002] "Syndrome_of_Inappropriate_Antidiuretic_Hormone_Secretion"                                                                                                             
[35003] "Smell"                                                                                                                                                                
[35004] "Specified"                                                                                                                                                            
[35005] "Speech"                                                                                                                                                               
[35006] "Spinal"                                                                                                                                                               
[35007] "Stage_Grouping"                                                                                                                                                       
[35008] "Swallowing"                                                                                                                                                           
[35009] "Tachycardia"                                                                                                                                                          
[35010] "Taste"                                                                                                                                                                
[35011] "Tearing"                                                                                                                                                              
[35012] "Therapeutic_Effect"                                                                                                                                                   
[35013] "Arthroscopy"                                                                                                                                                          
[35014] "Topography"                                                                                                                                                           
[35015] "Audiometric_Test"                                                                                                                                                     
[35016] "Total_Bilirubin"                                                                                                                                                      
[35017] "Tremor"                                                                                                                                                               
[35018] "Bone_Spectrometry"                                                                                                                                                    
[35019] "Bronchography"                                                                                                                                                        
[35020] "Troponin_T"                                                                                                                                                           
[35021] "Bronchoscopy_with_Bronchoalveolar_Lavage"                                                                                                                             
[35022] "Typhlitis"                                                                                                                                                            
[35023] "Cardiac_Catheterization"                                                                                                                                              
[35024] "Catheterization"                                                                                                                                                      
[35025] "Unspecified"                                                                                                                                                          
[35026] "Curative_Surgery"                                                                                                                                                     
[35027] "Vasovagal"                                                                                                                                                            
[35028] "Cystography"                                                                                                                                                          
[35029] "Veno-occlusive"                                                                                                                                                       
[35030] "Dental_Procedure"                                                                                                                                                     
[35031] "Electrocardiography"                                                                                                                                                  
[35032] "Electroencephalography"                                                                                                                                               
[35033] "Ventricular"                                                                                                                                                          
[35034] "Electromyography"                                                                                                                                                     
[35035] "Vertigo"                                                                                                                                                              
[35036] "Thallium_Myocardial_Perfusion_Imaging_Stress_Test"                                                                                                                    
[35037] "Visual"                                                                                                                                                               
[35038] "Eye_Examination"                                                                                                                                                      
[35039] "Withdrawn"                                                                                                                                                            
[35040] "Blood_Flow_Cytometry"                                                                                                                                                 
[35041] "Bone_Marrow_Cytometry"                                                                                                                                                
[35042] "Holter_Monitoring"                                                                                                                                                    
[35043] "Hyperbaric_Oxygen_Therapy"                                                                                                                                            
[35044] "Hysterosonography"                                                                                                                                                    
[35045] "Incision_and_Drainage"                                                                                                                                                
[35046] "Lavage"                                                                                                                                                               
[35047] "Lymphangiography"                                                                                                                                                     
[35048] "Lymphocyte_Harvest"                                                                                                                                                   
[35049] "Breast_Imaging_Reporting_and_Data_System_Mammography"                                                                                                                 
[35050] "Wolfe_Classification_Mammography"                                                                                                                                     
[35051] "Radionuclide_Ventriculogram_Scan"                                                                                                                                     
[35052] "Nasopharyngeal_Laryngoscopy"                                                                                                                                          
[35053] "Nasopharyngoscopy"                                                                                                                                                    
[35054] "Nipple_Discharge_Aspiration"                                                                                                                                          
[35055] "Ommaya_Reservoir_Access"                                                                                                                                              
[35056] "Percutaneous_Transluminal_Coronary_Angioplasty"                                                                                                                       
[35057] "Peritoneoscopy"                                                                                                                                                       
[35058] "Portacath_Placement"                                                                                                                                                  
[35059] "Pulmonary_Function_Test"                                                                                                                                              
[35060] "Inspired_Oxygen_Fraction_Test"                                                                                                                                        
[35061] "Carbon_Monoxide_Diffusing_Capability_Test"                                                                                                                            
[35062] "Forced_Expiratory_Volume_1_Test"                                                                                                                                      
[35063] "Pulse_Oximetry"                                                                                                                                                       
[35064] "Renography"                                                                                                                                                           
[35065] "Gallium_Scan"                                                                                                                                                         
[35066] "I-131_Uptake_and_Scan"                                                                                                                                                
[35067] "Indium_Scan"                                                                                                                                                          
[35068] "Lung_Perfusion_Scan"                                                                                                                                                  
[35069] "Sestamibi_Scan"                                                                                                                                                       
[35070] "Skeletal_Survey_X-Ray"                                                                                                                                                
[35071] "Tomography"                                                                                                                                                           
[35072] "Small_Bowel_Follow_Through_Procedure"                                                                                                                                 
[35073] "Urine_Casts"                                                                                                                                                          
[35074] "Vaginography"                                                                                                                                                         
[35075] "Vascular_Access_Device_Placement"                                                                                                                                     
[35076] "Venacavography"                                                                                                                                                       
[35077] "Venography"                                                                                                                                                           
[35078] "Ventilation_Perfusion_Scanning"                                                                                                                                       
[35079] "Radiography"                                                                                                                                                          
[35080] "Abdominal_Radiography"                                                                                                                                                
[35081] "Chest_Radiography"                                                                                                                                                    
[35082] "Pelvic_Examination"                                                                                                                                                   
[35083] "Myoid_Dermatofibrosarcoma_Protuberans"                                                                                                                                
[35084] "Myxoid_Dermatofibrosarcoma_Protuberans"                                                                                                                               
[35085] "Dedifferentiated_Dermatofibrosarcoma_Protuberans"                                                                                                                     
[35086] "Dermatofibrosarcoma_Protuberans_with_Giant_Cell_Fibroblastoma-Like_Differentiation"                                                                                   
[35087] "Basosebaceous_Basal_Cell_Carcinoma"                                                                                                                                   
[35088] "Signet_Ring_Cell_Basal_Cell_Carcinoma"                                                                                                                                
[35089] "Sarcomatoid_Basal_Cell_Carcinoma"                                                                                                                                     
[35090] "Esophagography"                                                                                                                                                       
[35091] "Cytology_Specimen_Collection_Procedure"                                                                                                                               
[35092] "Drug_Route_of_Administration"                                                                                                                                         
[35093] "Estradiol_Mustard"                                                                                                                                                    
[35094] "Murine_Monoclonal_Antibody_225"                                                                                                                                       
[35095] "HPV_16_E6_18-26_Peptide"                                                                                                                                              
[35096] "SBIL-2_Transduced_Autologous_Tumor-Infiltrating_Lymphocyte"                                                                                                           
[35097] "ESO-1_Reactive_Autologous_Peripheral_Blood_Lymphocyte"                                                                                                                
[35098] "ESO-1_Reactive_Autologous_Tumor_Infiltrating_Lymphocyte"                                                                                                              
[35099] "PR-151"                                                                                                                                                               
[35100] "VHL-42_65-76"                                                                                                                                                         
[35101] "VHL-59_116-128"                                                                                                                                                       
[35102] "gp100-Reactive_Autologous_Peripheral_Blood_Lymphocyte"                                                                                                                
[35103] "gp100-Reactive_Autologous_Tumor_Infiltrating_Lymphocyte"                                                                                                              
[35104] "Betulinic_Acid"                                                                                                                                                       
[35105] "_6-Aminonicotinamide"                                                                                                                                                 
[35106] "PPI-2458"                                                                                                                                                             
[35107] "SL11093"                                                                                                                                                              
[35108] "SB-715992"                                                                                                                                                            
[35109] "_12_Melanoma_Peptide"                                                                                                                                                 
[35110] "_6_Helper_Peptide"                                                                                                                                                    
[35111] "Tetanus_Helper_Peptide"                                                                                                                                               
[35112] "Anti-gp100_TCR_Retroviral_Vector-Transduced_Autologous_TIL"                                                                                                           
[35113] "Anti-gp100_TCR_Retroviral_Vector-Transduced_Autologous_PBL"                                                                                                           
[35114] "Anti-MART-1_TCR_Retroviral_Vector-Transduced_Autologous_TIL"                                                                                                          
[35115] "Ferumoxytol"                                                                                                                                                          
[35116] "Talampanel"                                                                                                                                                           
[35117] "Ferumoxtran-10"                                                                                                                                                       
[35118] "Pneumococcal_7-Valent_Conjugate_Vaccine"                                                                                                                              
[35119] "_17-Dimethylaminoethylamino_17-Demethoxygeldanamycin"                                                                                                                 
[35120] "Recombinant_NY-ESO-1_Protein"                                                                                                                                         
[35121] "Lansky_Play-Performance_Status"                                                                                                                                       
[35122] "Chronic_Allograft_Nephropathy"                                                                                                                                        
[35123] "Chronic_Allograft_Arteriopathy"                                                                                                                                       
[35124] "Ind-2"                                                                                                                                                                
[35125] "Ind-3"                                                                                                                                                                
[35126] "Antiparkinsonian_Agent"                                                                                                                                               
[35127] "Neoplasm_with_Perivascular_Epithelioid_Cell_Differentiation"                                                                                                          
[35128] "Epithelioid_Type_Angiomyolipoma"                                                                                                                                      
[35129] "Clear_Cell-Sugar-Tumor_of_the_Lung"                                                                                                                                   
[35130] "Lung_Lymphangioleiomyomatosis"                                                                                                                                        
[35131] "Clear_Cell_Myomelanocytic_Tumor_of_the_Falciform_Ligament_Ligamentum_Teres"                                                                                           
[35132] "Recurrent_Disease"                                                                                                                                                    
[35133] "Metachronous_Malignant_Neoplasm"                                                                                                                                      
[35134] "Metachronous_Osteosarcoma"                                                                                                                                            
[35135] "Metachronous_Wilms_Tumor"                                                                                                                                             
[35136] "Plasmablastic_Lymphoma_of_Mucosa_Site"                                                                                                                                
[35137] "AIDS-Related_Plasmablastic_Lymphoma_of_Mucosa_Site"                                                                                                                   
[35138] "Gastrointestinal_Non-Hodgkin_s_Lymphoma"                                                                                                                              
[35139] "Gastrointestinal_Lymphoma"                                                                                                                                            
[35140] "Gastrointestinal_Hodgkin_s_Lymphoma"                                                                                                                                  
[35141] "Male_Reproductive_System_Precancerous_Condition"                                                                                                                      
[35142] "Therapeutic_Urokinase"                                                                                                                                                
[35143] "Outer"                                                                                                                                                                
[35144] "CD10_Messenger_RNA_Overexpression"                                                                                                                                    
[35145] "BCL-6_Messenger_RNA_Overexpression"                                                                                                                                   
[35146] "A-myb_Messenger_RNA_Overexpression"                                                                                                                                   
[35147] "LMO2_Messenger_RNA_Overexpression"                                                                                                                                    
[35148] "PKCbeta1_Messenger_RNA_Overexpression"                                                                                                                                
[35149] "Cyclin_D2_Messenger_RNA_Overexpression"                                                                                                                               
[35150] "BCL-2_Messenger_RNA_Overexpression"                                                                                                                                   
[35151] "IRF4_MUM1_Messenger_RNA_Overexpression"                                                                                                                               
[35152] "CD44_Messenger_RNA_Overexpression"                                                                                                                                    
[35153] "BCL-2_Translocation"                                                                                                                                                  
[35154] "APRT_Gene"                                                                                                                                                            
[35155] "POMC_Gene"                                                                                                                                                            
[35156] "GC_Gene"                                                                                                                                                              
[35157] "_9q21"                                                                                                                                                                
[35158] "_18q21_1-q21_32"                                                                                                                                                      
[35159] "_4q28_2-q31_1"                                                                                                                                                        
[35160] "ALK_Gene"                                                                                                                                                             
[35161] "AGT_Gene"                                                                                                                                                             
[35162] "Clinical_or_Research_Facility"                                                                                                                                        
[35163] "Neuropeptide_Gene"                                                                                                                                                    
[35164] "KNG_Gene"                                                                                                                                                             
[35165] "CALCA_Gene"                                                                                                                                                           
[35166] "CRH_Gene"                                                                                                                                                             
[35167] "CD36_Gene"                                                                                                                                                            
[35168] "Auricular_Route_of_Drug_Administration"                                                                                                                               
[35169] "Buccal_Route_of_Drug_Administration"                                                                                                                                  
[35170] "Conjunctival_Route_of_Drug_Administration"                                                                                                                            
[35171] "KRT19_Gene"                                                                                                                                                           
[35172] "Continuous_Intravenous_Infusion"                                                                                                                                      
[35173] "Dental_Route_of_Drug_Administration"                                                                                                                                  
[35174] "Drug_Administration_into_Soft_Tissue"                                                                                                                                 
[35175] "Drug_Administration_via_Gastrostomy"                                                                                                                                  
[35176] "Drug_Administration_via_Hemodialysis"                                                                                                                                 
[35177] "Drug_Administration_via_Implantation"                                                                                                                                 
[35178] "Drug_Administration_via_Jejunostomy"                                                                                                                                  
[35179] "Drug_Iontophoresis"                                                                                                                                                   
[35180] "Endocervical_Route_of_Drug_Administration"                                                                                                                            
[35181] "Endosinusial_Route_of_Drug_Administration"                                                                                                                            
[35182] "Endothoracic_Route_of_Drug_Administration"                                                                                                                            
[35183] "Endotracheal_Route_of_Drug_Administration"                                                                                                                            
[35184] "Enteral_Route_of_Drug_Administration"                                                                                                                                 
[35185] "Epidural_Route_of_Drug_Administration"                                                                                                                                
[35186] "Extraamniotic_Route_of_Drug_Administration"                                                                                                                           
[35187] "Extracorporeal_Circulation_Route_of_Drug_Administration"                                                                                                              
[35188] "Extraluminal_Route_of_Drug_Administration"                                                                                                                            
[35189] "Genitourinary_Route_of_Drug_Administration"                                                                                                                           
[35190] "Infiltration_Route_of_Drug_Administration"                                                                                                                            
[35191] "Inhalation_Route_of_Drug_Administration"                                                                                                                              
[35192] "Intracoronal_Dental_Route_of_Drug_Administration"                                                                                                                     
[35193] "Intracoronary_Route_of_Drug_Administration"                                                                                                                           
[35194] "Interstitial_Route_of_Drug_Administration"                                                                                                                            
[35195] "Intraabdominal_Route_of_Drug_Administration"                                                                                                                          
[35196] "Intraamniotic_Route_of_Drug_Administration"                                                                                                                           
[35197] "Intraarterial_Route_of_Drug_Administration"                                                                                                                           
[35198] "Intraarticular_Route_of_Drug_Administration"                                                                                                                          
[35199] "Intrabiliary_Route_of_Drug_Administration"                                                                                                                            
[35200] "Intrabronchial_Route_of_Drug_Administration"                                                                                                                          
[35201] "Intrabursal_Route_of_Drug_Administration"                                                                                                                             
[35202] "Intracardiac_Route_of_Drug_Administration"                                                                                                                            
[35203] "Intracartilaginous_Route_of_Drug_Administration"                                                                                                                      
[35204] "Intracaudal_Route_of_Drug_Administration"                                                                                                                             
[35205] "Intracavernous_Route_of_Drug_Administration"                                                                                                                          
[35206] "Intracavitary_Route_of_Drug_Administration"                                                                                                                           
[35207] "Intracerebral_Route_of_Drug_Administration"                                                                                                                           
[35208] "Intracisternal_Route_of_Drug_Administration"                                                                                                                          
[35209] "Intracorneal_Route_of_Drug_Administration"                                                                                                                            
[35210] "Intracorporus_Cavernosum_Route_of_Drug_Administration"                                                                                                                
[35211] "Intracranial_Route_of_Drug_Administration"                                                                                                                            
[35212] "Intradermal_Route_of_Drug_Administration"                                                                                                                             
[35213] "Intradiscal_Route_of_Drug_Administration"                                                                                                                             
[35214] "Intraductal_Route_of_Drug_Administration"                                                                                                                             
[35215] "Intraduodenal_Route_of_Drug_Administration"                                                                                                                           
[35216] "Intradural_Route_of_Drug_Administration"                                                                                                                              
[35217] "Intraepidermal_Route_of_Drug_Administration"                                                                                                                          
[35218] "Intraepithelial_Route_of_Drug_Administration"                                                                                                                         
[35219] "Intraesophageal_Route_of_Drug_Administration"                                                                                                                         
[35220] "Intragastric_Route_of_Drug_Administration"                                                                                                                            
[35221] "Intragingival_Route_of_Drug_Administration"                                                                                                                           
[35222] "Intrahepatic_Route_of_Drug_Administration"                                                                                                                            
[35223] "Intraileal_Route_of_Drug_Administration"                                                                                                                              
[35224] "Intralesional_Route_of_Drug_Administration"                                                                                                                           
[35225] "Intraluminal_Route_of_Drug_Administration"                                                                                                                            
[35226] "Intralymphatic_Route_of_Drug_Administration"                                                                                                                          
[35227] "Intramedullary_Route_of_Drug_Administration"                                                                                                                          
[35228] "Intrameningeal_Route_of_Drug_Administration"                                                                                                                          
[35229] "Intraocular_Route_of_Drug_Administration"                                                                                                                             
[35230] "Intraovarian_Route_of_Drug_Administration"                                                                                                                            
[35231] "Intrapericardial_Route_of_Drug_Administration"                                                                                                                        
[35232] "Intraperitoneal_Route_of_Drug_Administration"                                                                                                                         
[35233] "Intrapleural_Route_of_Drug_Administration"                                                                                                                            
[35234] "Intraprostatic_Route_of_Drug_Administration"                                                                                                                          
[35235] "Intrapulmonary_Route_of_Drug_Administration"                                                                                                                          
[35236] "Intrasinal_Route_of_Drug_Administration"                                                                                                                              
[35237] "Intraspinal_Route_of_Drug_Administration"                                                                                                                             
[35238] "Intrasynovial_Route_of_Drug_Administration"                                                                                                                           
[35239] "Intratendinous_Route_of_Drug_Administration"                                                                                                                          
[35240] "Intratesticular_Route_of_Drug_Administration"                                                                                                                         
[35241] "Intrathecal_Route_of_Drug_Administration"                                                                                                                             
[35242] "Intratubular_Route_of_Drug_Administration"                                                                                                                            
[35243] "Intratumoral_Route_of_Drug_Administration"                                                                                                                            
[35244] "Intratypanic_Route_of_Drug_Administration"                                                                                                                            
[35245] "Intraurethral_Route_of_Drug_Administration"                                                                                                                           
[35246] "Intrauterine_Route_of_Drug_Administration"                                                                                                                            
[35247] "Intravascular_Route_of_Drug_Administration"                                                                                                                           
[35248] "Intravenous_Bolus"                                                                                                                                                    
[35249] "Intravenous_Infusion"                                                                                                                                                 
[35250] "Intravenous_Route_of_Drug_Administration"                                                                                                                             
[35251] "Intraventricular_Route_of_Drug_Administration"                                                                                                                        
[35252] "Intravesical_Route_of_Drug_Administration"                                                                                                                            
[35253] "Intravenous_Drip"                                                                                                                                                     
[35254] "Intravitreal_Route_of_Drug_Administration"                                                                                                                            
[35255] "Irrigation-Route_of_Drug_Administration"                                                                                                                              
[35256] "Laryngeal_Route_of_Drug_Administration"                                                                                                                               
[35257] "Mucosal_Route_of_Drug_Administration"                                                                                                                                 
[35258] "Nasal_Route_of_Drug_Administration"                                                                                                                                   
[35259] "Nasogastric_Route_of_Drug_Administration"                                                                                                                             
[35260] "Occlusive_Dressing_Technique"                                                                                                                                         
[35261] "Ophthalmic_Route_of_Drug_Administration"                                                                                                                              
[35262] "Oral_Route_of_Drug_administration"                                                                                                                                    
[35263] "Oropharyngeal_Route_of_Drug_Administration"                                                                                                                           
[35264] "Other_Routes_of_Drug_Administration"                                                                                                                                  
[35265] "Parenteral_Route_of_Drug_Administration"                                                                                                                              
[35266] "Periarticular_Route_of_Drug_Administration"                                                                                                                           
[35267] "Perineural_Route_of_Drug_Administration"                                                                                                                              
[35268] "Periodontal_Route_of_Drug_Administration"                                                                                                                             
[35269] "Rectal_Route_of_Drug_Administration"                                                                                                                                  
[35270] "Retrobulbar_Route_of_Drug_Administration"                                                                                                                             
[35271] "Subarachnoid_Route_of_Drug_Administration"                                                                                                                            
[35272] "Subconjunctival_Route_of_Drug_Administration"                                                                                                                         
[35273] "Subcutaneous_Route_of_Drug_Administration"                                                                                                                            
[35274] "Sublingual_Route_of_Drug_Administration"                                                                                                                              
[35275] "Submucosal_Route_of_Drug_Administration"                                                                                                                              
[35276] "Swish_and_Spit_Route_of_Drug_Administration"                                                                                                                          
[35277] "Swish_and_Swallow_Route_of_Drug_Administration"                                                                                                                       
[35278] "Topical_Route_of_Drug_Administration"                                                                                                                                 
[35279] "Transdermal_Route_of_Drug_Administration"                                                                                                                             
[35280] "Transluminal_Route_of_Drug_Administration"                                                                                                                            
[35281] "Transplacental_Route_of_Drug_Administration"                                                                                                                          
[35282] "Transtracheal_Route_of_Drug_Administration"                                                                                                                           
[35283] "Transtympanic_Route_of_Drug_Administration"                                                                                                                           
[35284] "Unassigned_Route_of_Drug_Administration"                                                                                                                              
[35285] "Unknown_Route_of_Drug_Administration"                                                                                                                                 
[35286] "Ureteral_Route_of_Drug_Administration"                                                                                                                                
[35287] "Vaginal_Route_of_Drug_Administration"                                                                                                                                 
[35288] "POLB_Gene"                                                                                                                                                            
[35289] "FOLH1_Gene"                                                                                                                                                           
[35290] "GNAQ_Gene"                                                                                                                                                            
[35291] "GNAS_Gene"                                                                                                                                                            
[35292] "GRP_Gene"                                                                                                                                                             
[35293] "GYPA_Gene"                                                                                                                                                            
[35294] "GHRH_Gene"                                                                                                                                                            
[35295] "Marginal_Zone_B-Lymphocyte_of_Nodal_Type"                                                                                                                             
[35296] "Peripheral_Epidermotropic_T-Lymphocyte"                                                                                                                               
[35297] "Mature_Cytotoxic_T-Lymphocyte"                                                                                                                                        
[35298] "Immature_T-Lymphocyte"                                                                                                                                                
[35299] "Immature_Peripheral_Gamma-Delta_Cell_of_Cytotoxic_Type"                                                                                                               
[35300] "Immature_Peripheral_Alpha-Beta_Cell_of_Cytotoxic_Type"                                                                                                                
[35301] "Unfavorable_Clinical_Outcome"                                                                                                                                         
[35302] "Thymic_B-Lymphocyte"                                                                                                                                                  
[35303] "Peripheral_B-Lymphocyte"                                                                                                                                              
[35304] "Intraepithelial_T-Lymphocyte"                                                                                                                                         
[35305] "Peripheral_B-Lymphocyte_of_Inner_Mantle_Zone"                                                                                                                         
[35306] "Activated_B-Lymphocyte"                                                                                                                                               
[35307] "Postgerminal_Center_Marginal_Zone_B-Lymphocyte"                                                                                                                       
[35308] "Germinal_Center_B-Lymphocyte"                                                                                                                                         
[35309] "Interdigitating_Dendritic_Cell"                                                                                                                                       
[35310] "Naive_Pregerminal_Center_B-Lymphocyte"                                                                                                                                
[35311] "Activated_Skin-Homing_Lymphocyte"                                                                                                                                     
[35312] "Postgerminal_Center_Memory_B-Lymphocyte"                                                                                                                              
[35313] "Postgerminal_Center_B-Lymphocyte"                                                                                                                                     
[35314] "Postgerminal_Center_B-Lymphocyte_of_Unknown_Differentiation_Stage"                                                                                                    
[35315] "Pancreatic_Intraductal_Papillary-Mucinous_Neoplasm"                                                                                                                   
[35316] "JAK-STAT_Pathway_Deregulation"                                                                                                                                        
[35317] "RAS-RAF_Pathway_Deregulation"                                                                                                                                         
[35318] "JUN_Pathway_Deregulation"                                                                                                                                             
[35319] "MYC_Pathway_Deregulation"                                                                                                                                             
[35320] "P13K-AKT_Pathway_Deregulation"                                                                                                                                        
[35321] "MSN-ALK_Fusion_Protein_Expression"                                                                                                                                    
[35322] "ESR1_Gene"                                                                                                                                                            
[35323] "del_4_q12"                                                                                                                                                            
[35324] "t_1_4_q44_q12"                                                                                                                                                        
[35325] "_6q25_1"                                                                                                                                                              
[35326] "_7q21"                                                                                                                                                                
[35327] "_1p31_3-p31_2"                                                                                                                                                        
[35328] "_9q13"                                                                                                                                                                
[35329] "_11q21-q22"                                                                                                                                                           
[35330] "_13q14_2-q14_3"                                                                                                                                                       
[35331] "_17p12-p11_2"                                                                                                                                                         
[35332] "_12q24_3"                                                                                                                                                             
[35333] "Estrogen_Receptor_1"                                                                                                                                                  
[35334] "AML1_Mutation"                                                                                                                                                        
[35335] "ESR2_Gene"                                                                                                                                                            
[35336] "Estrogen_Receptor_2"                                                                                                                                                  
[35337] "TOP3B_Gene"                                                                                                                                                           
[35338] "Topoisomerase-III_Beta"                                                                                                                                               
[35339] "USF1_Gene"                                                                                                                                                            
[35340] "Upstream_Stimulatory_Factor_1"                                                                                                                                        
[35341] "USF2_Gene"                                                                                                                                                            
[35342] "Upstream_Stimulatory_Factor_2"                                                                                                                                        
[35343] "GNAI1_Gene"                                                                                                                                                           
[35344] "C_EBPalpha_Mutation"                                                                                                                                                  
[35345] "OTT-MAL_Fusion_Protein_Expression"                                                                                                                                    
[35346] "t_8_22_p11_q13"                                                                                                                                                       
[35347] "t_V_11_v_q23"                                                                                                                                                         
[35348] "Acute_Promyelocytic_Leukemia_with_t_17_17_q11_q11"                                                                                                                    
[35349] "t_17_17_q11_q11"                                                                                                                                                      
[35350] "STAT5-RARalpha_Fusion_Protein_Expression"                                                                                                                             
[35351] "G-i_Alpha-1_Protein"                                                                                                                                                  
[35352] "GNAI3_Gene"                                                                                                                                                           
[35353] "G-i_Alpha-3_Protein"                                                                                                                                                  
[35354] "Aneuploid_Dysplastic_Oral_Leukoplakia"                                                                                                                                
[35355] "del_5_q12_q35"                                                                                                                                                        
[35356] "del_7_q11_q36"                                                                                                                                                        
[35357] "del_20_q11"                                                                                                                                                           
[35358] "MLL-AF10_Fusion_Protein_Expression"                                                                                                                                   
[35359] "Ventilator"                                                                                                                                                           
[35360] "Sex_Personal_Attribute"                                                                                                                                               
[35361] "MLL-AF9_Fusion_Protein_Expressin"                                                                                                                                     
[35362] "MLL-ENL_Fusion_Protein_Expression"                                                                                                                                    
[35363] "MLL-ELL_Fusion_Protein_Expression"                                                                                                                                    
[35364] "MLL-EEN_Fusion_Protein_Expression"                                                                                                                                    
[35365] "NFKBIB_Gene"                                                                                                                                                          
[35366] "I-Kappa-B-Beta_Protein"                                                                                                                                               
[35367] "NFKBIE_Gene"                                                                                                                                                          
[35368] "I-Kappa-B-Epsilon_Protein"                                                                                                                                            
[35369] "NF-I_Gene"                                                                                                                                                            
[35370] "NFIA_Gene"                                                                                                                                                            
[35371] "NF-IA_Protein"                                                                                                                                                        
[35372] "NFIB_Gene"                                                                                                                                                            
[35373] "NF-IB_Protein"                                                                                                                                                        
[35374] "NFIC-Gene"                                                                                                                                                            
[35375] "NF-IC_Protein"                                                                                                                                                        
[35376] "NFIX_Gene"                                                                                                                                                            
[35377] "NF-IX_Protein"                                                                                                                                                        
[35378] "C-KIT_Somatic_Point_Mutation"                                                                                                                                         
[35379] "Progressive_Transformation_of_Germinal_Centers"                                                                                                                       
[35380] "PRKACA_Gene"                                                                                                                                                          
[35381] "Protein_Kinase-A_C-Alpha"                                                                                                                                             
[35382] "PRKACB_Gene"                                                                                                                                                          
[35383] "Protein_Kinase-A_C-Beta"                                                                                                                                              
[35384] "PRKACG_Gene"                                                                                                                                                          
[35385] "Protein_Kinase-A_C-Gamma"                                                                                                                                             
[35386] "RXRA_Gene"                                                                                                                                                            
[35387] "Retinoid_X_Receptor_Alpha"                                                                                                                                            
[35388] "RXRB_Gene"                                                                                                                                                            
[35389] "Retinoid_X_Receptor_Beta"                                                                                                                                             
[35390] "RXRG_Gene"                                                                                                                                                            
[35391] "Retinoid_X_Receptor_Gamma"                                                                                                                                            
[35392] "GUCY1A2_Gene"                                                                                                                                                         
[35393] "Soluble_Guanylate_Cyclase-1-Alpha-2"                                                                                                                                  
[35394] "Pleomorphic_Reed_Sternberg_Cell"                                                                                                                                      
[35395] "GUCY1A3_Gene"                                                                                                                                                         
[35396] "_4q31_3-q33"                                                                                                                                                          
[35397] "Soluble_Guanylate_Cyclase-1-Alpha-3"                                                                                                                                  
[35398] "GUCY1B2_Gene"                                                                                                                                                         
[35399] "Soluble_Guanylate_Cyclase-1-Beta-2"                                                                                                                                   
[35400] "GUCY1B3_Gene"                                                                                                                                                         
[35401] "Soluble_Guanylate_Cyclase-1-Beta-3"                                                                                                                                   
[35402] "UBB_Gene"                                                                                                                                                             
[35403] "Ubiquitin-B"                                                                                                                                                          
[35404] "UBC_Gene"                                                                                                                                                             
[35405] "Peripheral_Post-Thymic_T-Lymphocyte"                                                                                                                                  
[35406] "Ubiquitin-C"                                                                                                                                                          
[35407] "Mature_B-Lymphocyte_at_the_Germinal_Center_Stage_of_Differentiation"                                                                                                  
[35408] "UBD_Gene"                                                                                                                                                             
[35409] "Ubiquitin-D"                                                                                                                                                          
[35410] "Mature_Lymphocyte"                                                                                                                                                    
[35411] "Abnormal_Immunology_Test_Result"                                                                                                                                      
[35412] "Interleukin-2_Overexpression"                                                                                                                                         
[35413] "Interleukin-5_Overexpression"                                                                                                                                         
[35414] "Interleukin-6_Overexpression"                                                                                                                                         
[35415] "Interleukin-7_Overexpression"                                                                                                                                         
[35416] "Interleukin-9_Overexpression"                                                                                                                                         
[35417] "Interleukin-10_Overexpression"                                                                                                                                        
[35418] "Interleukin-13_Overexpression"                                                                                                                                        
[35419] "Lymphotoxin-Alpha_Overexpression"                                                                                                                                     
[35420] "Colony-Stimulating_Factor_Overexpression"                                                                                                                             
[35421] "Peer_Pressure"                                                                                                                                                        
[35422] "Clonal_BCL-3_Gene_Rearrangement"                                                                                                                                      
[35423] "Serrated_Adenoma"                                                                                                                                                     
[35424] "AP12-MLT_Fusion_Protein_Expression"                                                                                                                                   
[35425] "del_11q24"                                                                                                                                                            
[35426] "Caspase_Inhibitor"                                                                                                                                                    
[35427] "Partial_Thromboplastin_Time_Test"                                                                                                                                     
[35428] "Hair_Part"                                                                                                                                                            
[35429] "Lymph_Node_Part"                                                                                                                                                      
[35430] "Interfollicular_Area_of_the_Lymph_Node"                                                                                                                               
[35431] "_5-Hydroxypicolinaldehyde_Thiosemicarbazone"                                                                                                                          
[35432] "Constitutional_Symptom"                                                                                                                                               
[35433] "Lab_Finding"                                                                                                                                                          
[35434] "Commercial_or_Non-CTEP_IND_Agents"                                                                                                                                    
[35435] "_2p15"                                                                                                                                                                
[35436] "_3q26_2-qter"                                                                                                                                                         
[35437] "_3q27_3"                                                                                                                                                              
[35438] "_4q21-q24"                                                                                                                                                            
[35439] "_8p21_2"                                                                                                                                                              
[35440] "_9q31_1"                                                                                                                                                              
[35441] "_9pter-p22_1"                                                                                                                                                         
[35442] "_10q24_1-q25_1"                                                                                                                                                       
[35443] "_10q21-q22"                                                                                                                                                           
[35444] "_12q24_2-q24_31"                                                                                                                                                      
[35445] "_16q12_1"                                                                                                                                                             
[35446] "_16q22-q23_1"                                                                                                                                                         
[35447] "_17q23_2-q25_3"                                                                                                                                                       
[35448] "_17p13_1-q25"                                                                                                                                                         
[35449] "Micrometastasis_Finding"                                                                                                                                              
[35450] "TUBG1_Gene"                                                                                                                                                           
[35451] "Gamma_Tubulin-1"                                                                                                                                                      
[35452] "TUBG2_Gene"                                                                                                                                                           
[35453] "Gamma_Tubulin-2"                                                                                                                                                      
[35454] "GNRH1_Gene"                                                                                                                                                           
[35455] "Gonadotrophin_Releasing_Hormone-1"                                                                                                                                    
[35456] "GNRH2_Gene"                                                                                                                                                           
[35457] "Gonadotrophin_Releasing_Hormone-2"                                                                                                                                    
[35458] "HPRT1_Gene"                                                                                                                                                           
[35459] "Hypoxanthine_Phosphoribosyltransferase-1"                                                                                                                             
[35460] "HPRT2_Gene"                                                                                                                                                           
[35461] "Hypoxanthine_Phosphoribosyltransferase-2"                                                                                                                             
[35462] "GOT1_Gene"                                                                                                                                                            
[35463] "Aspartate_Aminotransferase-1"                                                                                                                                         
[35464] "GOT2_Gene"                                                                                                                                                            
[35465] "Aspartate_Aminotransferase-2"                                                                                                                                         
[35466] "GPT_Gene"                                                                                                                                                             
[35467] "Microscopic_Colitis"                                                                                                                                                  
[35468] "Glutamic-Pyruvate_Transaminase"                                                                                                                                       
[35469] "GPT2_Gene"                                                                                                                                                            
[35470] "Glutamic-Pyruvate_Transaminase-2"                                                                                                                                     
[35471] "Spleen_Part"                                                                                                                                                          
[35472] "TK1_Gene"                                                                                                                                                             
[35473] "Thymidine_Kinase-1"                                                                                                                                                   
[35474] "Thymidine_Kinase-2"                                                                                                                                                   
[35475] "TK2_Gene"                                                                                                                                                             
[35476] "Thymic_Lymphoid_Tissue"                                                                                                                                               
[35477] "Tonsilar_Tissue"                                                                                                                                                      
[35478] "TFRC_Gene"                                                                                                                                                            
[35479] "Tonsillar_Lymphoid_Tissue"                                                                                                                                            
[35480] "Transferrin_Receptor-1"                                                                                                                                               
[35481] "TFR2_Gene"                                                                                                                                                            
[35482] "Transferrin_Receptor-2"                                                                                                                                               
[35483] "PPP3CA_Gene"                                                                                                                                                          
[35484] "Calcineurin-A_Alpha"                                                                                                                                                  
[35485] "PPP3CB_Gene"                                                                                                                                                          
[35486] "Calcineurin-A_Beta"                                                                                                                                                   
[35487] "PPP3CC_Gene"                                                                                                                                                          
[35488] "Calcineurin-A_Gamma"                                                                                                                                                  
[35489] "PPP3R1_Gene"                                                                                                                                                          
[35490] "Calcineurin-B_Type-I"                                                                                                                                                 
[35491] "PPP3R2_Gene"                                                                                                                                                          
[35492] "Calcineurin-B_Type-II"                                                                                                                                                
[35493] "Sight"                                                                                                                                                                
[35494] "CREB_Family_Gene"                                                                                                                                                     
[35495] "Touch"                                                                                                                                                                
[35496] "CREB1_Gene"                                                                                                                                                           
[35497] "cAMP_Responsive_Element_Binding_Protein-1"                                                                                                                            
[35498] "CREB3_Gene"                                                                                                                                                           
[35499] "cAMP_Responsive_Element_Binding_Protein-3"                                                                                                                            
[35500] "CREB4_Gene"                                                                                                                                                           
[35501] "cAMP_Responsive_Element_Binding_Protein-4"                                                                                                                            
[35502] "CREB5_Gene"                                                                                                                                                           
[35503] "cAMP_Responsive_Element_Binding_Protein-5"                                                                                                                            
[35504] "EIF2B1_Gene"                                                                                                                                                          
[35505] "Translation_Initiation_Factor-EIF-2B_Alpha_Subunit"                                                                                                                   
[35506] "EIF2B2_Gene"                                                                                                                                                          
[35507] "Translation_Initiation_Factor-EIF-2B_Beta_Subunit"                                                                                                                    
[35508] "EIF2B4_Gene"                                                                                                                                                          
[35509] "Translation_Initiation_Factor-EIF-2B_Delta_Subunit"                                                                                                                   
[35510] "EIF2B5_Gene"                                                                                                                                                          
[35511] "Translation_Initiation_Factor-EIF-2B_Epsilon_Subunit"                                                                                                                 
[35512] "FCGR2A_Gene"                                                                                                                                                          
[35513] "IgG-Fc-Receptor-IIA"                                                                                                                                                  
[35514] "FCGR2B_Gene"                                                                                                                                                          
[35515] "IgG-Fc-Receptor-IIB"                                                                                                                                                  
[35516] "FCGR2C_Gene"                                                                                                                                                          
[35517] "IgG-Fc-Receptor-IIC"                                                                                                                                                  
[35518] "FCGR3A_Gene"                                                                                                                                                          
[35519] "IgG-Fc-Receptor-IIIA"                                                                                                                                                 
[35520] "FCGR3B_Gene"                                                                                                                                                          
[35521] "IgG-Fc-Receptor-IIIB"                                                                                                                                                 
[35522] "NOS1_Gene"                                                                                                                                                            
[35523] "Nitric_Oxide_Synthetase-1"                                                                                                                                            
[35524] "NOS2A_Gene"                                                                                                                                                           
[35525] "Nitric_Oxide_Synthase-2A"                                                                                                                                             
[35526] "NOS2B_Gene"                                                                                                                                                           
[35527] "Nitric_Oxide_Synthase-2B"                                                                                                                                             
[35528] "NOS2C_Gene"                                                                                                                                                           
[35529] "Nitric_Oxide_Synthase-2C"                                                                                                                                             
[35530] "NOS3_Gene"                                                                                                                                                            
[35531] "Nitric_Oxide_Synthase-3"                                                                                                                                              
[35532] "Leucine_Rich_Repeat_Containing_Protein-17"                                                                                                                            
[35533] "Cooperative_Prostate_Cancer_Tissue_Resource"                                                                                                                          
[35534] "Syncytiotrophoblastic_Cell"                                                                                                                                           
[35535] "Cytotrophoblastic_Cell"                                                                                                                                               
[35536] "Translation_Process_Protein"                                                                                                                                          
[35537] "RARG_Gene"                                                                                                                                                            
[35538] "Retinoic_Acid_Receptor_Gamma"                                                                                                                                         
[35539] "EEF1A1_Gene"                                                                                                                                                          
[35540] "_6q14_1"                                                                                                                                                              
[35541] "Elongation_Factor-1A1"                                                                                                                                                
[35542] "EEF1A2_Gene"                                                                                                                                                          
[35543] "Elongation_Factor-1A2"                                                                                                                                                
[35544] "EEF2_Gene"                                                                                                                                                            
[35545] "_19pter-q12"                                                                                                                                                          
[35546] "Elongation_Factor-2"                                                                                                                                                  
[35547] "Anti-MART-1_TCR_Retroviral_Vector-Transduced_Autologous_PBL"                                                                                                          
[35548] "PLA2G4A_Gene"                                                                                                                                                         
[35549] "Cytosolic_Phospholipase-A2G4A"                                                                                                                                        
[35550] "_15q11_2-q21_3"                                                                                                                                                       
[35551] "PLA2G4B_Gene"                                                                                                                                                         
[35552] "Cytosolic_Phospholipase-A2G4B"                                                                                                                                        
[35553] "PLA2G4C_Gene"                                                                                                                                                         
[35554] "Cytosolic_Phospholipase-A2G4C"                                                                                                                                        
[35555] "PLA2G4D_Gene"                                                                                                                                                         
[35556] "Cytosolic_Phospholipase-A2G4D"                                                                                                                                        
[35557] "PLA2G6_Gene"                                                                                                                                                          
[35558] "Cytosolic_Phospholipase-A2G6"                                                                                                                                         
[35559] "FNTA_Gene"                                                                                                                                                            
[35560] "_8p22-q11"                                                                                                                                                            
[35561] "CAAX-Farnesyltransferase_Alpha-Subunit"                                                                                                                               
[35562] "_14q23-q24"                                                                                                                                                           
[35563] "FNTB_Gene"                                                                                                                                                            
[35564] "CAAX-Farnesyltransferase_Beta_Subunit"                                                                                                                                
[35565] "GCLM_Gene"                                                                                                                                                            
[35566] "Gamma-Glutamylcysteine_Synthetase_Regulatory_Protein"                                                                                                                 
[35567] "GCLC_Gene"                                                                                                                                                            
[35568] "Gamma-Glutamylcysteine_Synthetase_Catalytic_Subunit"                                                                                                                  
[35569] "ADORA1_Gene"                                                                                                                                                          
[35570] "Adenosine-A1_Receptor"                                                                                                                                                
[35571] "ADORA2A_Gene"                                                                                                                                                         
[35572] "Adenosine-A2A_Receptor"                                                                                                                                               
[35573] "ADORA2B_Gene"                                                                                                                                                         
[35574] "Adenosine-A2B_Receptor"                                                                                                                                               
[35575] "ADORA3_Gene"                                                                                                                                                          
[35576] "Adenosine-A3_Receptor"                                                                                                                                                
[35577] "Head_and_Neck_Part"                                                                                                                                                   
[35578] "PRIM2A_Gene"                                                                                                                                                          
[35579] "Primase_Polypeptide-2A"                                                                                                                                               
[35580] "Integumentary_System_Part"                                                                                                                                            
[35581] "Diaphragm_Part"                                                                                                                                                       
[35582] "Epithelium_Part"                                                                                                                                                      
[35583] "Extracellular_Matrix_Part"                                                                                                                                            
[35584] "Tissue_Part"                                                                                                                                                          
[35585] "Organ_of_Special_Sense_Part"                                                                                                                                          
[35586] "Membrane_Part"                                                                                                                                                        
[35587] "Upper_Extremity_Part"                                                                                                                                                 
[35588] "Lower_Extremity_Part"                                                                                                                                                 
[35589] "Extremity_Part"                                                                                                                                                       
[35590] "Opening_of_the_Thorax"                                                                                                                                                
[35591] "Tonsil_Part"                                                                                                                                                          
[35592] "Electro-osmosis_Route_of_Drug_Administration"                                                                                                                         
[35593] "Doppler_Echocardiography"                                                                                                                                             
[35594] "inv_22q12"                                                                                                                                                            
[35595] "t_11_17_q13q11"                                                                                                                                                       
[35596] "t_12_21_p13_q22_TEL-AML1"                                                                                                                                             
[35597] "t_1_14_q21-22q32"                                                                                                                                                     
[35598] "Delta_Cell_of_the_Pancreas"                                                                                                                                           
[35599] "Neoplastic_B-Lymphocyte"                                                                                                                                              
[35600] "Neoplastic_T-Lymphocyte"                                                                                                                                              
[35601] "Lymphoblasts_25_Percent_or_Less_of_Bone_Marrow_Nucleated_Cells"                                                                                                       
[35602] "Extensive_Bone_Marrow_and_Blood_Involvement"                                                                                                                          
[35603] "Bone_Pain"                                                                                                                                                            
[35604] "Tartrate_Resistant_Acid_Phosphatase_Positivity"                                                                                                                       
[35605] "Fried-Egg_Appearance_of_the_Bone_Marrow"                                                                                                                              
[35606] "Prolymphocytes_Exceed_55_Percent_of_Lymphoid_Cells_in_the_Peripheral_Blood"                                                                                           
[35607] "Negative_Bone_Marrow_and_Peripheral_Blood"                                                                                                                            
[35608] "Vacuolated_Plasma_Cells_in_the_Bone_Marrow"                                                                                                                           
[35609] "Defective_Mu_Heavy_Chain_Present"                                                                                                                                     
[35610] "Nuclear_Pleomorphism_Present"                                                                                                                                         
[35611] "Bone_Marrow_and_Blood_Involvement"                                                                                                                                    
[35612] "Bulky_Disease"                                                                                                                                                        
[35613] "ALK_Kinase_Upregulation"                                                                                                                                              
[35614] "Neoplastic_Immunoblast-Like_B-Lymphocyte"                                                                                                                             
[35615] "Transformed_Peripheral_B-Lymphocyte"                                                                                                                                  
[35616] "Neoplastic_Large_B-Lymphocyte_with_Pale_Cytoplasm"                                                                                                                    
[35617] "Composite_Lymphoma"                                                                                                                                                   
[35618] "Pericardial_Cavity"                                                                                                                                                   
[35619] "Postmeiotic_Segregation_Increased-2-Like-1"                                                                                                                           
[35620] "Chest_Pain"                                                                                                                                                           
[35621] "Monomorphic_Cellular_Infiltrate"                                                                                                                                      
[35622] "Polymorphic_Cellular_Infiltrate"                                                                                                                                      
[35623] "Intrahepatic_Portion_of_the_Left_Hepatic_Duct"                                                                                                                        
[35624] "Intrahepatic_Portion_of_the_Right_Hepatic_Duct"                                                                                                                       
[35625] "Hilar_Portion_of_the_Left_Hepatic_Duct"                                                                                                                               
[35626] "Hilar_Portion_of_the_Right_Hepatic_Duct"                                                                                                                              
[35627] "Transforming_Growth_Factor-Beta_Induced_Protein-IGH3"                                                                                                                 
[35628] "T-Cell_Large_Granular_Lymphocyte"                                                                                                                                     
[35629] "Widespread_Disease"                                                                                                                                                   
[35630] "Cutaneous_Route_of_Drug_Administration"                                                                                                                               
[35631] "Percutaneous_Route_of_Drug_Administration"                                                                                                                            
[35632] "Peridural_Route_of_Drug_Administration"                                                                                                                               
[35633] "Yttrium_Y_90_Monoclonal_Antibody_Hu3S193"                                                                                                                             
[35634] "Yttrium_Y_90_Glass_Microspheres"                                                                                                                                      
[35635] "Valeriana_Officinalis"                                                                                                                                                
[35636] "Vaccinia-PSA-TRICOM_Vaccine"                                                                                                                                          
[35637] "Recombinant_Tyrosinase-Related_Protein-2"                                                                                                                             
[35638] "Traumeel_S"                                                                                                                                                           
[35639] "TAC-101"                                                                                                                                                              
[35640] "Siplizumab"                                                                                                                                                           
[35641] "Ruthenium_106"                                                                                                                                                        
[35642] "Methoxypolyethylene_Glycol_Epoetin_beta"                                                                                                                              
[35643] "Ravuconazole"                                                                                                                                                         
[35644] "Polyphenon_E"                                                                                                                                                         
[35645] "PI-88"                                                                                                                                                                
[35646] "Phentolamine"                                                                                                                                                         
[35647] "Pertuzumab"                                                                                                                                                           
[35648] "Paricalcitol"                                                                                                                                                         
[35649] "OSI-7904L"                                                                                                                                                            
[35650] "Multi-epitope_Melanoma_Peptide_Vaccine"                                                                                                                               
[35651] "Moxifloxacin"                                                                                                                                                         
[35652] "Monoclonal_Antibody_HuHMFG1"                                                                                                                                          
[35653] "Hyperviscosity"                                                                                                                                                       
[35654] "Melanoma_Helper_Peptide_Vaccine"                                                                                                                                      
[35655] "Lutetium_Lu_177_Monoclonal_Antibody_J591"                                                                                                                             
[35656] "Neoplastic_Small_B-Lymphocyte"                                                                                                                                        
[35657] "Lamotrigine"                                                                                                                                                          
[35658] "Absorbable_Gelatin_Sponge"                                                                                                                                            
[35659] "Garlic"                                                                                                                                                               
[35660] "Fruit_and_Vegetable_Extracts"                                                                                                                                         
[35661] "Fowlpox-PSA-TRICOM_Vaccine"                                                                                                                                           
[35662] "Deslorelin"                                                                                                                                                           
[35663] "Defective_Gamma_Heavy_Chain_Present"                                                                                                                                  
[35664] "CC-8490"                                                                                                                                                              
[35665] "Carbon-11_Acetate"                                                                                                                                                    
[35666] "BMS-354825"                                                                                                                                                           
[35667] "BB-10901"                                                                                                                                                             
[35668] "Autologous-Immunoglobulin-Idiotype-KLH-Conjugate-Vaccine"                                                                                                             
[35669] "Anidulafungin"                                                                                                                                                        
[35670] "Anakinra"                                                                                                                                                             
[35671] "AG-013736"                                                                                                                                                            
[35672] "_3-AP_Fludarabine"                                                                                                                                                    
[35673] "Transgenic_Lymphocyte_Immunization_Vaccine"                                                                                                                           
[35674] "Nuclear_Pleomorphism"                                                                                                                                                 
[35675] "High-Dose_Chemotherapy_with_Stem_Cell_Support"                                                                                                                        
[35676] "Humanized_Monoclonal_Antibody_LM609"                                                                                                                                  
[35677] "Recombinant_MAGE-3-1_Antigen"                                                                                                                                         
[35678] "Valeriana_Officinalis_Extract"                                                                                                                                        
[35679] "Human_Papillomavirus_16_E6_Peptide"                                                                                                                                   
[35680] "Villous_Lymphocyte"                                                                                                                                                   
[35681] "Proteolytic_Enzymes"                                                                                                                                                  
[35682] "Marginal_Zone_B-Lymphocyte"                                                                                                                                           
[35683] "Lymphoepithelial_Lesion_Present"                                                                                                                                      
[35684] "Villous_Atrophy"                                                                                                                                                      
[35685] "Defective_Alpha_Heavy_Chain_Present"                                                                                                                                  
[35686] "Mouse_Hepatic_System_Neoplasm"                                                                                                                                        
[35687] "Mouse_Bile_Duct_Hyperplasia"                                                                                                                                          
[35688] "Mouse_Cholangiocarcinoma"                                                                                                                                             
[35689] "Mouse_Cholangioma"                                                                                                                                                    
[35690] "Mouse_Hepatocellular_Hyperplasia"                                                                                                                                     
[35691] "Mouse_Oval_Cell_Hyperplasia"                                                                                                                                          
[35692] "Mouse_Pre-Neoplastic_Hepatocellular_Foci"                                                                                                                             
[35693] "Mouse_Hepatocholangiocellular_Adenoma"                                                                                                                                
[35694] "Mouse_Hepatocholangiocellular_Adenocarcinoma"                                                                                                                         
[35695] "Mouse_Ito_Cell_Tumor"                                                                                                                                                 
[35696] "Non-Neoplastic_Proliferation_of_the_Mouse_Liver"                                                                                                                      
[35697] "Mouse_Liver_Disorder"                                                                                                                                                 
[35698] "Hepatocellular_Adenoma_of_the_Mouse"                                                                                                                                  
[35699] "Hepatocellular_Carcinoma_of_the_Mouse"                                                                                                                                
[35700] "Negative_Finding"                                                                                                                                                     
[35701] "Positive_Finding"                                                                                                                                                     
[35702] "Epstein-Barr_Virus_Infection"                                                                                                                                         
[35703] "Submucosal_Invasive_Colon_Adenocarcinoma"                                                                                                                             
[35704] "HPV_16E7_86-93_Lipopeptide_Vaccine"                                                                                                                                   
[35705] "Mucoepidermoid_Thyroid_Carcinoma"                                                                                                                                     
[35706] "Sclerosing_Mucoepidermoid_Thyroid_Carcinoma_with_Eosinophilia"                                                                                                        
[35707] "Scaffolding_Protein"                                                                                                                                                  
[35708] "Squamoid_Differentiation"                                                                                                                                             
[35709] "Lymphocytic_Thyroiditis"                                                                                                                                              
[35710] "Chronic_Lymphocytic_Thyroiditis"                                                                                                                                      
[35711] "Mucinous_Differentiation"                                                                                                                                             
[35712] "Therapeutic_Tyrosinase-Related_Protein-2"                                                                                                                             
[35713] "Squamous_Differentiation"                                                                                                                                             
[35714] "Benign_Neoplasms_of_Mouse_Liver"                                                                                                                                      
[35715] "Malignant_Neoplasms_of_Mouse_Liver"                                                                                                                                   
[35716] "CD19_Gene"                                                                                                                                                            
[35717] "_11q12"                                                                                                                                                               
[35718] "_1p36_2"                                                                                                                                                              
[35719] "_2q12-q22"                                                                                                                                                            
[35720] "_3p21_2"                                                                                                                                                              
[35721] "_6p11_2"                                                                                                                                                              
[35722] "_7q31_3-q32"                                                                                                                                                          
[35723] "_9p13-p12"                                                                                                                                                            
[35724] "CD19_Antigen"                                                                                                                                                         
[35725] "MS4A1_Gene"                                                                                                                                                           
[35726] "CD20_Antigen"                                                                                                                                                         
[35727] "CD3_Complex"                                                                                                                                                          
[35728] "CD3D_Gene"                                                                                                                                                            
[35729] "T-Cell_Receptor-T3_Delta_Chain"                                                                                                                                       
[35730] "CD3G_Gene"                                                                                                                                                            
[35731] "T-Cell_Receptor-T3_Gamma_Chain"                                                                                                                                       
[35732] "CD3Z_Gene"                                                                                                                                                            
[35733] "T-Cell_Receptor-T3_Zeta_Chain"                                                                                                                                        
[35734] "T-Cell_Receptor-T3_Eta_Chain"                                                                                                                                         
[35735] "TNFRSF8_Gene"                                                                                                                                                         
[35736] "TNF_Receptor-8"                                                                                                                                                       
[35737] "CD52_Gene"                                                                                                                                                            
[35738] "CD52_Antigen"                                                                                                                                                         
[35739] "GNRHR_Gene"                                                                                                                                                           
[35740] "Gonadotropin-Releasing_Hormone_Receptor"                                                                                                                              
[35741] "IL1R1_Gene"                                                                                                                                                           
[35742] "Interleukin-1-Receptor_Alpha_Type-I"                                                                                                                                  
[35743] "IL1R2_Gene"                                                                                                                                                           
[35744] "Interleukin-1-Receptor_Beta_Type-II"                                                                                                                                  
[35745] "Interleukin-12_Receptor"                                                                                                                                              
[35746] "IL12RB1_Gene"                                                                                                                                                         
[35747] "Interleukin-12-Receptor_Beta-1-Chain"                                                                                                                                 
[35748] "IL12RB2_Gene"                                                                                                                                                         
[35749] "Interleukin-12-Receptor_Beta-2-Chain"                                                                                                                                 
[35750] "IL6R_Gene"                                                                                                                                                            
[35751] "Interleukin-6-Receptor_Alpha_Subunit"                                                                                                                                 
[35752] "IMPDH1_Gene"                                                                                                                                                          
[35753] "IMP-Dehydrogenase-1"                                                                                                                                                  
[35754] "IMPDH2_Gene"                                                                                                                                                          
[35755] "IMP-Dehydrogenase-2"                                                                                                                                                  
[35756] "CAD_Gene"                                                                                                                                                             
[35757] "Aspartate_Carbamoyltransferase"                                                                                                                                       
[35758] "FRAP1_Gene"                                                                                                                                                           
[35759] "FKBP12-Rapamycin_Complex_Associated_Protein-1"                                                                                                                        
[35760] "ODC1_Gene"                                                                                                                                                            
[35761] "Ornithine_Decarboxylase-1"                                                                                                                                            
[35762] "GLIPR2_Gene"                                                                                                                                                          
[35763] "Golgi-Associated_PR-1_Protein"                                                                                                                                        
[35764] "CD7_Gene"                                                                                                                                                             
[35765] "T-Cell_Antigen_CD7"                                                                                                                                                   
[35766] "Grade_I_Meningioma"                                                                                                                                                   
[35767] "Grade_II_Meningioma"                                                                                                                                                  
[35768] "Grade_III_Meningioma"                                                                                                                                                 
[35769] "MUC1_Gene"                                                                                                                                                            
[35770] "_14q32_31"                                                                                                                                                            
[35771] "_7p22_2"                                                                                                                                                              
[35772] "_2p16_1"                                                                                                                                                              
[35773] "_17q21_32"                                                                                                                                                            
[35774] "_12q11-q13"                                                                                                                                                           
[35775] "_11q12_3"                                                                                                                                                             
[35776] "PAPOLA_Gene"                                                                                                                                                          
[35777] "Polynucleotide_Adenylyltransferase_Alpha"                                                                                                                             
[35778] "PAPOLB_Gene"                                                                                                                                                          
[35779] "Polynucleotide_Adenylyltransferase_Beta"                                                                                                                              
[35780] "PAPOLG_Gene"                                                                                                                                                          
[35781] "Polynucleotide_Adenylyltransferase_Gamma"                                                                                                                             
[35782] "High_Affinity_Interleukin-2_Receptor"                                                                                                                                 
[35783] "Integrin-aVBeta3"                                                                                                                                                     
[35784] "ITGB3_Gene"                                                                                                                                                           
[35785] "Integrin_Beta-3"                                                                                                                                                      
[35786] "ITGA5_Gene"                                                                                                                                                           
[35787] "Elongation_Factor-1"                                                                                                                                                  
[35788] "EEF1B1_Gene"                                                                                                                                                          
[35789] "Elongation_Factor-1B1"                                                                                                                                                
[35790] "EEF1B2_Gene"                                                                                                                                                          
[35791] "Elongation_Factor-1B2"                                                                                                                                                
[35792] "EEF1D_Gene"                                                                                                                                                           
[35793] "Elongation_Factor-1D"                                                                                                                                                 
[35794] "EEF1G_Gene"                                                                                                                                                           
[35795] "Elongation_Factor-1G"                                                                                                                                                 
[35796] "Mucin-1"                                                                                                                                                              
[35797] "GM-CSF_Receptor"                                                                                                                                                      
[35798] "CSF2RA_Gene"                                                                                                                                                          
[35799] "Colony_Stimulating_Factor-2-Receptor_Alpha_Chain"                                                                                                                     
[35800] "Interleukin-3_Receptor"                                                                                                                                               
[35801] "IL3RA_Gene"                                                                                                                                                           
[35802] "Interleukin-3_Receptor_Alpha"                                                                                                                                         
[35803] "BioCarta_Myosin_Pathway"                                                                                                                                              
[35804] "CDC91L1_Gene"                                                                                                                                                         
[35805] "GPI-Transamidase_Component-PIGU"                                                                                                                                      
[35806] "FOLR1_Gene"                                                                                                                                                           
[35807] "Folate_Receptor-1"                                                                                                                                                    
[35808] "CTAG1_Gene"                                                                                                                                                           
[35809] "Cancer-Testis_Antigen-1"                                                                                                                                              
[35810] "_20q11_22"                                                                                                                                                            
[35811] "_11q13_3-q14_1"                                                                                                                                                       
[35812] "Human_Herpes_Virus_8_Infection"                                                                                                                                       
[35813] "HTLV-1_Infection"                                                                                                                                                     
[35814] "Helicobacter_Pylori_Infection"                                                                                                                                        
[35815] "Schistosoma_Hematobium_Infection"                                                                                                                                     
[35816] "Opisthorchis_Viverrini_Infection"                                                                                                                                     
[35817] "HP_Gene"                                                                                                                                                              
[35818] "CGB_Gene"                                                                                                                                                             
[35819] "Adolescence"                                                                                                                                                          
[35820] "Pediatric"                                                                                                                                                            
[35821] "Precursor_NK-Cell"                                                                                                                                                    
[35822] "Neoplastic_Medium-Sized_Natural_Killer_Cell"                                                                                                                          
[35823] "Abramson_Cancer_Center_at_the_University_of_Pennsylvania"                                                                                                             
[35824] "Active_Funded_Research_Project"                                                                                                                                       
[35825] "Agency_for_Healthcare_Research_and_Quality"                                                                                                                           
[35826] "Albert_Einstein_Cancer_Center"                                                                                                                                        
[35827] "Alliance_for_Lung_Cancer_Advocacy_Support_and_Education"                                                                                                              
[35828] "American_Association_for_the_Advancement_of_Science"                                                                                                                  
[35829] "American_Association_of_Cancer_Research"                                                                                                                              
[35830] "American_Brain_Tumor_Association"                                                                                                                                     
[35831] "American_College_of_Obstetricians_and_Gynecologists"                                                                                                                  
[35832] "American_College_of_Oncology_Administrators"                                                                                                                          
[35833] "American_College_of_Physicians"                                                                                                                                       
[35834] "American_College_of_Radiation_Oncology"                                                                                                                               
[35835] "American_College_of_Radiology"                                                                                                                                        
[35836] "American_Joint_Committee_on_Cancer"                                                                                                                                   
[35837] "American_Lung_Association"                                                                                                                                            
[35838] "American_Medical_Association"                                                                                                                                         
[35839] "American_Public_Health_Association"                                                                                                                                   
[35840] "American_Society_of_Clinical_Oncology"                                                                                                                                
[35841] "American_Society_of_Hematology"                                                                                                                                       
[35842] "Analytical_Biochemistry_Shared_Resource"                                                                                                                              
[35843] "Animal_Models_Service_Shared_Resource"                                                                                                                                
[35844] "Animal_Pharmacology_Shared_Resource"                                                                                                                                  
[35845] "Association_of_American_Cancer_Institutes"                                                                                                                            
[35846] "Association_of_American_Medical_Colleges"                                                                                                                             
[35847] "Association_of_Community_Cancer_Centers"                                                                                                                              
[35848] "Bachelor_s_Degree"                                                                                                                                                    
[35849] "Barbara_Ann_Karmano_Cancer_Institute"                                                                                                                                 
[35850] "Barrier_Animal_Facility_Shared_Resource"                                                                                                                              
[35851] "Bioinformatics_Shared_Resource"                                                                                                                                       
[35852] "Biosafety_Service_Shared_Resource"                                                                                                                                    
[35853] "Biostatistics_Shared_Resource"                                                                                                                                        
[35854] "Board_of_Scientific_Advisors_NCI"                                                                                                                                     
[35855] "California_Breast_Cancer_Research_Program"                                                                                                                            
[35856] "Cancer_Center_at_Cold_Spring_Harbor_Laboratory"                                                                                                                       
[35857] "Cancer_Center_at_the_Burnham_Institute"                                                                                                                               
[35858] "Cancer_Center_at_the_Salk_Institute_for_Biological_Studies"                                                                                                           
[35859] "Cancer_Center_of_University_of_California_Irvine"                                                                                                                     
[35860] "Cancer_Center_Organizational_Capabilities_Section_of_Cancer_Center_Support_Grant_Application"                                                                         
[35861] "Cancer_Center_Planning_Grant"                                                                                                                                         
[35862] "Cancer_Center_Support_Grant_Application"                                                                                                                              
[35863] "Cancer_Clinical_and_Economic_Outcomes_Shared_Resource"                                                                                                                
[35864] "Cancer_Institute_at_Oregon_Health_and_Science_University"                                                                                                             
[35865] "Cancer_Institute_of_New_Jersey"                                                                                                                                       
[35866] "Cancer_Patient_Education_Network"                                                                                                                                     
[35867] "Cancer_Prevention_Biomarker_and_Genotyping_Shared_Resource"                                                                                                           
[35868] "Cancer_Research_and_Prevention_Foundation"                                                                                                                            
[35869] "Cancer_Research_Center_of_Hawaii"                                                                                                                                     
[35870] "Cancer_Treatment_Research_Foundation"                                                                                                                                 
[35871] "Center_for_Cancer_Research_at_the_Massachusetts_Institute_of_Technology"                                                                                              
[35872] "CHAI_Foundation"                                                                                                                                                      
[35873] "Children_s_Cancer_Group"                                                                                                                                              
[35874] "Children_s_Oncology_Group"                                                                                                                                            
[35875] "Chromatography_Shared_Resource"                                                                                                                                       
[35876] "City_of_Hope_Comprehensive_Cancer_Center"                                                                                                                             
[35877] "Clinical_Informatics_Shared_Resource"                                                                                                                                 
[35878] "Clinical_Pathway"                                                                                                                                                     
[35879] "Clinical_Protocol_Date_Closed_Standard_Cancer_Center_Information_Summary"                                                                                             
[35880] "Clinical_Protocol_Date_Opened_Standard_Cancer_Center_Information_Summary"                                                                                             
[35881] "Clinical_Research_Support_Shared_Resource"                                                                                                                            
[35882] "Clinical_Trials_Protocol_and_Data_Management_Shared_Resource"                                                                                                         
[35883] "Clinical_Trials_Scientific_Review_and_Monitoring_System"                                                                                                              
[35884] "Cloning_Laboratory_Shared_Resource"                                                                                                                                   
[35885] "Common_Scientific_Outline_NCI"                                                                                                                                        
[35886] "Community_Trial"                                                                                                                                                      
[35887] "Comprehensive_Cancer_Center_at_the_University_of_Arizona_Health_Sciences_Center_in_Tucson"                                                                            
[35888] "Comprehensive_Cancer_Center_of_Wake_Forest_University"                                                                                                                
[35889] "Computer_Retrieval_of_Information_on_Scientific_Projects_Database"                                                                                                    
[35890] "Computer_Service_Shared_Resource"                                                                                                                                     
[35891] "Consolidated_Budget_Request_of_Cancer_Center_Support_Grant_Application"                                                                                               
[35892] "Cure_for_Lymphoma_Foundation"                                                                                                                                         
[35893] "Cytogenetics_Shared_Resource"                                                                                                                                         
[35894] "Damon_Runyon_Cancer_Research_Foundation"                                                                                                                              
[35895] "Dana-Farber_Cancer_Institute"                                                                                                                                         
[35896] "Data_Compilation_and_Analysis_Shared_Resource"                                                                                                                        
[35897] "Digital_Imaging_Shared_Resource"                                                                                                                                      
[35898] "Director_of_Cancer_Research_Center"                                                                                                                                   
[35899] "DNA_RNA_and_Peptide_Synthesis_Shared_Resource"                                                                                                                        
[35900] "DNA_Sequencing_Shared_Resource"                                                                                                                                       
[35901] "Doctor_of_Chiropractic"                                                                                                                                               
[35902] "Doctor_of_Dental_Medicine"                                                                                                                                            
[35903] "Doctor_of_Dental_Surgery"                                                                                                                                             
[35904] "Doctor_of_Medicine"                                                                                                                                                   
[35905] "Doctor_of_Optometry"                                                                                                                                                  
[35906] "Doctor_of_Osteopathic_Medicine"                                                                                                                                       
[35907] "Doctor_of_Pharmacy"                                                                                                                                                   
[35908] "Doctor_of_Philosophy"                                                                                                                                                 
[35909] "Doctor_of_Philosophy_in_Human_Services"                                                                                                                               
[35910] "Doctor_of_Podiatric_Medicine"                                                                                                                                         
[35911] "Doctor_of_Public_Health"                                                                                                                                              
[35912] "Doctor_of_Veterinary_Medicine"                                                                                                                                        
[35913] "Doctor_s_Degree"                                                                                                                                                      
[35914] "Duke_Comprehensive_Cancer_Center"                                                                                                                                     
[35915] "Electron_Microscopy_Shared_Resource"                                                                                                                                  
[35916] "Epidemiology_and_Cancer_Control_Shared_Resource"                                                                                                                      
[35917] "European_Organisation_for_Research_and_Treatment_of_Cancer"                                                                                                           
[35918] "Experimental_Pathology_and_Histopathology_Shared_Resource"                                                                                                            
[35919] "Experimental_Pathology_Shared_Resource"                                                                                                                               
[35920] "Externally_Peer-Reviewed_Trial_Standard_Cancer_Center_Information_Summary"                                                                                            
[35921] "Familial_Cancer_Risk_Shared_Resource"                                                                                                                                 
[35922] "Fellow_of_American_College_of_Physicians"                                                                                                                             
[35923] "Fellow_of_American_College_of_Surgeons"                                                                                                                               
[35924] "Fermentation_Shared_Resource"                                                                                                                                         
[35925] "Field_Survey"                                                                                                                                                         
[35926] "Flow_Cytometry_Shared_Resource"                                                                                                                                       
[35927] "Fly_Facility_Shared_Resource"                                                                                                                                         
[35928] "Fox_Chase_Cancer_Center"                                                                                                                                              
[35929] "Fred_Hutchinson_Cancer_Research_Center"                                                                                                                               
[35930] "Funding_Agency"                                                                                                                                                       
[35931] "Gene_Therapy_and_Vector_Shared_Resource"                                                                                                                              
[35932] "General_and_Equipment_Repair_Shared_Resource"                                                                                                                         
[35933] "Genomics_and_Proteomics_Shared_Resource"                                                                                                                              
[35934] "Genomics_Shared_Resource"                                                                                                                                             
[35935] "Glasswashing_and_Sterilization_Shared_Resource"                                                                                                                       
[35936] "H_Lee_Moffitt_Cancer_Center_and_Research_Institute_at_the_University_of_South_Florida"                                                                                
[35937] "Health_Care_Delivery_Study"                                                                                                                                           
[35938] "Health_Resources_and_Services_Administration"                                                                                                                         
[35939] "Herbert_Irving_Comprehensive_Cancer_Center"                                                                                                                           
[35940] "Histology_and_Immunohistochemistry_Shared_Resource"                                                                                                                   
[35941] "Holden_Comprehensive_Cancer_Center_at_the_University_of_Iowa"                                                                                                         
[35942] "Human_Pharmacology_Study"                                                                                                                                             
[35943] "Huntsman_Cancer_Institute_at_the_University_of_Utah"                                                                                                                  
[35944] "Illustration_Graphic_Art_Publication_and_Audiovisual_Service_Shared_Resource"                                                                                         
[35945] "Immune_Monitoring_Shared_Resource"                                                                                                                                    
[35946] "Immunoelectron_Microscopy_Shared_Facility"                                                                                                                            
[35947] "In_Situ_Hybridization_Shared_Resource"                                                                                                                                
[35948] "Indiana_University_Cancer_Center"                                                                                                                                     
[35949] "Industrial_Trial_Standard_Cancer_Center_Information_Summary"                                                                                                          
[35950] "Institute_for_Cancer_Prevention"                                                                                                                                      
[35951] "Institutional_Commitment_Section_of_Cancer_Center_Support_Grant_Application"                                                                                          
[35952] "International_Agency_for_Research_on_Cancer"                                                                                                                          
[35953] "International_Cancer_Research_Portfolio_Database"                                                                                                                     
[35954] "International_Society_of_Preventive_Oncology"                                                                                                                         
[35955] "International_Union_Against_Cancer"                                                                                                                                   
[35956] "Intervention_Community_Trial"                                                                                                                                         
[35957] "Ireland_Cancer_Centerat_University_Hospitals_of_Cleveland_and_Case_Western_Reserve_University"                                                                        
[35958] "Irradiation_Shared_Resource"                                                                                                                                          
[35959] "Jonsson_Comprehensive_Cancer_Center_of_University_of_California_Los_Angeles"                                                                                          
[35960] "Kaplan_Cancer_Center"                                                                                                                                                 
[35961] "Kimmel_Cancer_Center_at_the_Thomas_Jefferson_University"                                                                                                              
[35962] "Laboratory_Animal_Genetic_Monitoring_Resource"                                                                                                                        
[35963] "Laboratory_Animal_Health_and_Quality_Control_Shared_Resource"                                                                                                         
[35964] "Laboratory_Animal_Husbandry_Shared_Resource"                                                                                                                          
[35965] "Laboratory_Animal_Shared_Resource"                                                                                                                                    
[35966] "Local_Protocol_Standard_Cancer_Center_Information_Summary"                                                                                                            
[35967] "Machine_Shop_Shared_Resource"                                                                                                                                         
[35968] "Mass_Spectrometry_Shared_Resource"                                                                                                                                    
[35969] "Massey_Cancer_Center_at_the_Virginia_Commonwealth_University"                                                                                                         
[35970] "Master_of_Business_Administration"                                                                                                                                    
[35971] "Master_of_Health_Services_Administration"                                                                                                                             
[35972] "Master_of_Public_Health"                                                                                                                                              
[35973] "Master_of_Science"                                                                                                                                                    
[35974] "Master_s_Degree"                                                                                                                                                      
[35975] "Mayo_Clinic_Cancer_Center"                                                                                                                                            
[35976] "McArdle_Laboratory_for_Cancer_Research"                                                                                                                               
[35977] "Media_Preparation_Shared_Resource"                                                                                                                                    
[35978] "Memorial_Sloan-Kettering_Cancer_Center"                                                                                                                               
[35979] "Microarray_Shared_Resource"                                                                                                                                           
[35980] "Molecular_Biology_Shared_Resource"                                                                                                                                    
[35981] "Molecular_Diagnostics_Laboratory_Shared_Resource"                                                                                                                     
[35982] "Molecular_Imaging_Shared_Resource"                                                                                                                                    
[35983] "Monoclonal_Antibody_Production_Shared_Resource"                                                                                                                       
[35984] "Mouse_Pathology_Shared_Resource"                                                                                                                                      
[35985] "National_Alliance_of_Breast_Cancer_Organizations"                                                                                                                     
[35986] "National_Brain_Tumor_Foundation"                                                                                                                                      
[35987] "National_Cancer_Institute_Cancer_Centers_Program"                                                                                                                     
[35988] "National_Cancer_Institute_of_Canada_Clinical_Trials_Group"                                                                                                            
[35989] "National_Cervical_Cancer_Coalition"                                                                                                                                   
[35990] "National_Childhood_Cancer_Foundation"                                                                                                                                 
[35991] "National_Coalition_for_Cancer_Research"                                                                                                                               
[35992] "National_Comprehensive_Cancer_Network"                                                                                                                                
[35993] "National_Protocol_Standard_Cancer_Center_Information_Summary"                                                                                                         
[35994] "Naturopathic_Doctor"                                                                                                                                                  
[35995] "NCI-Funded_Research_Portfolio_Database"                                                                                                                               
[35996] "Neuroblastoma_Children_s_Cancer_Society"                                                                                                                              
[35997] "Non-programmatically_Aligned_Cancer_Center_Research_Member_Section_of_Cancer_Center_Support_Grant_Application"                                                        
[35998] "Norris_Cotton_Cancer_Center"                                                                                                                                          
[35999] "Nuclear_Magnetic_Resonance_Shared_Resource"                                                                                                                           
[36000] "Nude_Mouse_Shared_Resource"                                                                                                                                           
[36001] "Nutrition_Shared_Resource"                                                                                                                                            
[36002] "Office_of_Assistant_Secretary_of_Health"                                                                                                                              
[36003] "Oligonucleotide_Synthesis_Shared_Resource"                                                                                                                            
[36004] "Optical_Microscopy_Shared_Resource"                                                                                                                                   
[36005] "Organic_and_Synthetic_Chemistry_Shared_Resource"                                                                                                                      
[36006] "Other_Clinical_Research_Support_Shared_Resource"                                                                                                                      
[36007] "Other_Epidemiology_and_Cancer_Control_Shared_Resource"                                                                                                                
[36008] "Other_Informatics_Shared_Resource"                                                                                                                                    
[36009] "Other_Laboratory_Science_Support_Shared_Resource"                                                                                                                     
[36010] "P20_Planning_Cancer_Center"                                                                                                                                           
[36011] "Patient_Compliance"                                                                                                                                                   
[36012] "Peer-reviewed_Scientific_Project"                                                                                                                                     
[36013] "Pharmaceutical_Research_Shared_Resource"                                                                                                                              
[36014] "Pharmacoeconomic_Study"                                                                                                                                               
[36015] "Pharmacology_Shared_Resource"                                                                                                                                         
[36016] "Pre-Clinical_Magnetic_Resonance_Imaging_Shared_Resource"                                                                                                              
[36017] "Preventive_Clinical_Trial"                                                                                                                                            
[36018] "Preventive_Community_Trial"                                                                                                                                           
[36019] "Proteomics_Shared_Resource"                                                                                                                                           
[36020] "Protocol_Development_Shared_Resource"                                                                                                                                 
[36021] "Public_Affairs_Network_of_Cancer_Centers"                                                                                                                             
[36022] "Public_Health_and_Epidemiology_Informatics_Shared_Resource"                                                                                                           
[36023] "Purdue_Cancer_Center"                                                                                                                                                 
[36024] "Radiolabeling_Shared_Resource"                                                                                                                                        
[36025] "Rebecca_and_John_Moores_University_of_California_at_San_Diego_Cancer_Center"                                                                                          
[36026] "Reportable_Cancer_Standard_Cancer_Center_Information_Summary"                                                                                                         
[36027] "Reportable_Patient_Standard_Cancer_Center_Information_Summary"                                                                                                        
[36028] "Reporting_Period_for_Cancer_Center_Support_Grant"                                                                                                                     
[36029] "Robert_H_Lurie_Comprehensive_Cancer_Center_of_Northwestern_University"                                                                                                
[36030] "Roswell_Park_Cancer_Institute"                                                                                                                                        
[36031] "Saint_Jude_Children_s_Research_Hospital"                                                                                                                              
[36032] "San_Antonio_Cancer_Institute"                                                                                                                                         
[36033] "Secretarial_and_Word_Processing_Shared_Resource"                                                                                                                      
[36034] "Shared_Resource_Cancer_Center"                                                                                                                                        
[36035] "Sidney_Kimmel_Cancer_Center_at_Johns_Hopkins_University"                                                                                                              
[36036] "Small_Animal_Imaging_Shared_Resource"                                                                                                                                 
[36037] "Small_Molecule_Screening_Shared_Resource"                                                                                                                             
[36038] "Social_Science_Shared_Resource"                                                                                                                                       
[36039] "Specialized_Program_of_Research_Excellence"                                                                                                                           
[36040] "Standard_Cancer_Center_Information_Summary"                                                                                                                           
[36041] "Study_of_Disease_Management"                                                                                                                                          
[36042] "Study_of_Disease_Mechanisms"                                                                                                                                          
[36043] "Substance_Abuse_and_Mental_Health_Services_Administration"                                                                                                            
[36044] "Survey_Shared_Resource"                                                                                                                                               
[36045] "Susan_G_Komen_Breast_Cancer_Foundation"                                                                                                                               
[36046] "Targeted_Accrual_Standard_Cancer_Center_Information_Summary"                                                                                                          
[36047] "Technology_Development_Study"                                                                                                                                         
[36048] "The_Antitumor_Testing_Shared_Resource"                                                                                                                                
[36049] "The_Comprehensive_Cancer_Center_Arthur_G_James_Cancer_Hospital_and_Richard_J_Solove_Research_Institute_at_Ohio_State_University"                                      
[36050] "The_Jackson_Laboratory"                                                                                                                                               
[36051] "The_Lombardi_Cancer_Center"                                                                                                                                           
[36052] "The_University_of_California_Davis_Clinical_Cancer_Center"                                                                                                            
[36053] "The_University_of_California_San_Francisco_Cancer_Center"                                                                                                             
[36054] "The_University_of_Colorado_Cancer_Center"                                                                                                                             
[36055] "The_Vanderbilt-Ingram_Cancer_Center_at_the_Vanderbilt_University"                                                                                                     
[36056] "The_Wistar_Institute"                                                                                                                                                 
[36057] "Therapeutic_Clinical_Trial"                                                                                                                                           
[36058] "Therapeutic_Confirmatory_Study"                                                                                                                                       
[36059] "Therapeutic_Exploratory_Study"                                                                                                                                        
[36060] "Therapeutic_Use_Study"                                                                                                                                                
[36061] "Tissue_Culture_Shared_Resource"                                                                                                                                       
[36062] "Tissue_Procurement_and_Distribution_Shared_Resource"                                                                                                                  
[36063] "Toxicology_and_Mutagenesis_Testing_Shared_Resource"                                                                                                                   
[36064] "Transgenic_and_Mutant_Animals_Shared_Resource"                                                                                                                        
[36065] "Translational_Cell_Therapy_Shared_Resource"                                                                                                                           
[36066] "Translational_Research_Shared_Resource"                                                                                                                               
[36067] "Treatment_Effectiveness"                                                                                                                                              
[36068] "Treatment_Efficacy"                                                                                                                                                   
[36069] "University_of_Alabama_at_Birmingham_Cancer_Center"                                                                                                                    
[36070] "University_of_Chicago_Cancer_Research_Center"                                                                                                                         
[36071] "University_of_Colorado_Cancer_Center"                                                                                                                                 
[36072] "University_of_Michigan_Comprehensive_Cancer_Center"                                                                                                                   
[36073] "University_of_Minnesota_Cancer_Center"                                                                                                                                
[36074] "University_of_Nebraska_Medical_Center_Eppley_Center_for_Cancer_Research_and_Cancer_Care"                                                                              
[36075] "University_of_North_Carolina_Chapel_Hill_Lineberger_Cancer_Center"                                                                                                    
[36076] "University_of_Pittsburgh_Cancer_Institute"                                                                                                                            
[36077] "University_of_Southern_California_Norris_Cancer_Center"                                                                                                               
[36078] "University_of_Texas_M_D_Anderson_Cancer_Center"                                                                                                                       
[36079] "University_of_Virginia_Cancer_Center"                                                                                                                                 
[36080] "University_of_Wisconsin_Comprehensive_Cancer_Center"                                                                                                                  
[36081] "US_Army_Medical_Research_and_Materiel_Command"                                                                                                                        
[36082] "Vermont_Cancer_Center_at_the_University_of_Vermont"                                                                                                                   
[36083] "X-ray_Crystallography_Shared_Resource"                                                                                                                                
[36084] "Yale_Cancer_Center"                                                                                                                                                   
[36085] "Health_Care_Visit"                                                                                                                                                    
[36086] "Coarse_Azurophilic_Granules_Present"                                                                                                                                  
[36087] "Neoplastic_T-Lymphocyte_and_Neoplastic_Natural_Killer_Cell"                                                                                                           
[36088] "T-Lymphocyte_and_Natural_Killer_Cell"                                                                                                                                 
[36089] "Peripheral_T-Lymphocyte_and_Natural_Killer_Cell"                                                                                                                      
[36090] "Cytoplasmic_Protrusions_Present"                                                                                                                                      
[36091] "Cutaneous_Involvement"                                                                                                                                                
[36092] "Neoplastic_Small_T-Prolymphocyte"                                                                                                                                     
[36093] "Neoplastic_Cerebriform_T-Prolymphocyte"                                                                                                                               
[36094] "T-Lymphocyte_with_a_Post-Thymic_Immunophenotype"                                                                                                                      
[36095] "Type_1a_Autoimmune_Lymphoproliferative_Syndrome"                                                                                                                      
[36096] "Type_1b_Autoimmune_Lymphoproliferative_Syndrome"                                                                                                                      
[36097] "Type_2_Autoimmune_Lymphoproliferative_Syndrome"                                                                                                                       
[36098] "Type_3_Autoimmune_Lymphoproliferative_Syndrome"                                                                                                                       
[36099] "Autoimmune_Lymphoproliferative_Syndrome-Associated_Lymphoma"                                                                                                          
[36100] "FAS_Gene_Mutation"                                                                                                                                                    
[36101] "FAS_Ligand_Gene_Mutation"                                                                                                                                             
[36102] "Casp_8_Gene_Mutation"                                                                                                                                                 
[36103] "Casp_10_Gene_Mutation"                                                                                                                                                
[36104] "FAS_Apoptosis_Pathway_Deregulation"                                                                                                                                   
[36105] "T-Cell_Large_Granular_Lymphocyte_Leukemia_Common_Varianr"                                                                                                             
[36106] "T_Gamma-Delta_Lymphocyte"                                                                                                                                             
[36107] "T-Cell_Large_Granular_Lymphocyte_Leukemia_Expressing_the_T-Cell_Receptor_Gamma-Delta"                                                                                 
[36108] "Xanthine_Dehydrogenase"                                                                                                                                               
[36109] "Serum_Soluble_Fas_Ligand_Level_Increased"                                                                                                                             
[36110] "Angioinvasion"                                                                                                                                                        
[36111] "XDH_Gene"                                                                                                                                                             
[36112] "Indolent_NK-Cell_Lymphoproliferative_Disorder"                                                                                                                        
[36113] "Integrin_Alpha-5"                                                                                                                                                     
[36114] "Peripheral_Blood_Involvement"                                                                                                                                         
[36115] "Skin_Rash"                                                                                                                                                            
[36116] "Lactate_Dehydrogenase_Increased"                                                                                                                                      
[36117] "CCND2_Gene"                                                                                                                                                           
[36118] "PRKCB1_Gene"                                                                                                                                                          
[36119] "CEBPA_Gene"                                                                                                                                                           
[36120] "Polylobated_T-Lymphocyte"                                                                                                                                             
[36121] "Neoplastic_Medium-Sized_T-Lymphocyte"                                                                                                                                 
[36122] "Pleomorphic_Small_T-Lymphocyte"                                                                                                                                       
[36123] "Pleomorphic_Medium-Sized_to_Large_T-Lymphocyte"                                                                                                                       
[36124] "Osteoclastic_Activity_Present"                                                                                                                                        
[36125] "Pautrier-like_Microabscess_Present"                                                                                                                                   
[36126] "Neoplastic_Small_T-Lymphocyte"                                                                                                                                        
[36127] "Neoplastic_Small_to_Medium-Sized_T-Lymphocyte"                                                                                                                        
[36128] "Recombinant_Tissue_Plasminogen_Activator"                                                                                                                             
[36129] "Coagulative_Necrosis"                                                                                                                                                 
[36130] "Activated_Natural-Killer_Cell"                                                                                                                                        
[36131] "Small_Intestinal_Enteropathy-Type_T-Cell_Lymphoma"                                                                                                                    
[36132] "Intestinal_Perforation"                                                                                                                                               
[36133] "Intestinal_Ulcerated_Mass"                                                                                                                                            
[36134] "Intraepithelial_T-Lymphocyte_of_the_Intestine"                                                                                                                        
[36135] "Neoplastic_Medium-Sized_to_Large_T-Lymphocyte"                                                                                                                        
[36136] "Sinusoidal_Infiltration"                                                                                                                                              
[36137] "Karyorrhexis"                                                                                                                                                         
[36138] "Subcutaneous_Involvement"                                                                                                                                             
[36139] "Subcutaneous_Nodule"                                                                                                                                                  
[36140] "DNA_Vaccine"                                                                                                                                                          
[36141] "Dermatopathic_Lymphadenopathy"                                                                                                                                        
[36142] "Cerebriform_Lymphocyte"                                                                                                                                               
[36143] "Scaly_Skin_Eruption"                                                                                                                                                  
[36144] "Skin_Patches"                                                                                                                                                         
[36145] "Skin_Plaques"                                                                                                                                                         
[36146] "Extracutaneous_Dissemination_of_Disease"                                                                                                                              
[36147] "Epidermotropic_Lymphocytic_Infiltrate"                                                                                                                                
[36148] "Pautrier_Microabscess_Present"                                                                                                                                        
[36149] "Single_Cell_Exocytosis"                                                                                                                                               
[36150] "CDKN2A_Gene_Inactivation"                                                                                                                                             
[36151] "Follicular_Lymphocytic_Infiltrate"                                                                                                                                    
[36152] "Xp22_1"                                                                                                                                                               
[36153] "_4q31_1"                                                                                                                                                              
[36154] "_4q31-q32"                                                                                                                                                            
[36155] "_6p25_3"                                                                                                                                                              
[36156] "_6q25_3"                                                                                                                                                              
[36157] "_6p22_2-p21_3"                                                                                                                                                        
[36158] "_7p15_1"                                                                                                                                                              
[36159] "_7q21_3-q22"                                                                                                                                                          
[36160] "_8q24_2-q24_3"                                                                                                                                                        
[36161] "Mucinous_Degeneration"                                                                                                                                                
[36162] "_11q14-q21"                                                                                                                                                           
[36163] "SOD2_Gene"                                                                                                                                                            
[36164] "Elastophagocytosis"                                                                                                                                                   
[36165] "Mycosis_Fungoides_Variant"                                                                                                                                            
[36166] "NR3C2_Gene"                                                                                                                                                           
[36167] "Erythroderma"                                                                                                                                                         
[36168] "NPY_Gene"                                                                                                                                                             
[36169] "Lutzner_Cell"                                                                                                                                                         
[36170] "OXT_Gene"                                                                                                                                                             
[36171] "SERPINE1_Gene"                                                                                                                                                        
[36172] "Proliferation_of_High_Endothelial_Venules_Present"                                                                                                                    
[36173] "Proliferation_of_Follicular_Dendritic_Cells_Present"                                                                                                                  
[36174] "SERPINB2_Gene"                                                                                                                                                        
[36175] "SERPINA5_Gene"                                                                                                                                                        
[36176] "PRL_Gene"                                                                                                                                                             
[36177] "Neoplastic_T-Lymphocyte_with_Clear_Cytoplasm"                                                                                                                         
[36178] "Bronchiolitis"                                                                                                                                                        
[36179] "Acute_Bronchiolitis"                                                                                                                                                  
[36180] "PTMA_Gene"                                                                                                                                                            
[36181] "Chest_Wall_Mass"                                                                                                                                                      
[36182] "SAT_Gene"                                                                                                                                                             
[36183] "Intrauterine_Mass"                                                                                                                                                    
[36184] "TAC1_Gene"                                                                                                                                                            
[36185] "Tzanck_Cell"                                                                                                                                                          
[36186] "TG_Gene"                                                                                                                                                              
[36187] "Dyskeratotic_Cell"                                                                                                                                                    
[36188] "TRH_Gene"                                                                                                                                                             
[36189] "TDO2_Gene"                                                                                                                                                            
[36190] "TYR_Gene"                                                                                                                                                             
[36191] "Dual_Specificity_Phosphatase-22"                                                                                                                                      
[36192] "Insulin_Receptor-Related_Receptor"                                                                                                                                    
[36193] "Insulin-Like_Peptide-4"                                                                                                                                               
[36194] "Small_Cell_Variant_Anaplastic_Large_Cell_Lymphoma_Giant_Cell_Rich_Subtype"                                                                                            
[36195] "Small_Cell_Variant_Anaplastic_Large_Cell_Lymphoma_Sarcomatoid_Subtype"                                                                                                
[36196] "Small_Cell_Variant_Anaplastic_Large_Cell_Lymphoma_Signet_Ring_like_Subtype"                                                                                           
[36197] "Flu-Matrix_Antigen"                                                                                                                                                   
[36198] "Anaplastic_T-Cell"                                                                                                                                                    
[36199] "Hallmark_Cell"                                                                                                                                                        
[36200] "Doughnut_Cell"                                                                                                                                                        
[36201] "Neoplastic_Small_to_Medium-Sized_T-Lymphocyte_with_Irregular_Nucleus"                                                                                                 
[36202] "Flower-like_T-Lymphocyte"                                                                                                                                             
[36203] "Signet_Ring-like_Neoplastic_T-Lymphocyte"                                                                                                                             
[36204] "Jambul"                                                                                                                                                               
[36205] "Devils_Claw"                                                                                                                                                          
[36206] "Transformed_Skin-Homing_T-Lymphocyte"                                                                                                                                 
[36207] "Activated_Mature_Cytotoxic_T-Lymphocyte"                                                                                                                              
[36208] "Localized_Skin_Lesion"                                                                                                                                                
[36209] "Multicentric_Cutaneous_Involvement"                                                                                                                                   
[36210] "Skin_Papules"                                                                                                                                                         
[36211] "Partial_Spontaneous_Regression"                                                                                                                                       
[36212] "Complete_Spontaneous_Regression"                                                                                                                                      
[36213] "Histiocytic_Infiltrate"                                                                                                                                               
[36214] "Sarcomatoid_Features"                                                                                                                                                 
[36215] "Extranodal_Disease"                                                                                                                                                   
[36216] "Aluminum_Hydroxide"                                                                                                                                                   
[36217] "Cerebriform-like_Lymphocyte"                                                                                                                                          
[36218] "Confluent_Sheets_of_Anaplastic_T-Lymphocytes_Present"                                                                                                                 
[36219] "Solitary_Skin_Tumor"                                                                                                                                                  
[36220] "C-KIT_Tyrosine_Kinase_Protein_Overexpression"                                                                                                                         
[36221] "C-KIT_Mutation"                                                                                                                                                       
[36222] "Vitamin_D_Analog"                                                                                                                                                     
[36223] "DN-101"                                                                                                                                                               
[36224] "CD30-Positive_Neoplastic_Cells_Present"                                                                                                                               
[36225] "EGFR_Protein_Overexpression"                                                                                                                                          
[36226] "MDM2_Gene_Mutation"                                                                                                                                                   
[36227] "PDGFRalpha_Gene_Mutation"                                                                                                                                             
[36228] "PDGFRalpha_Protein_Overexpression"                                                                                                                                    
[36229] "Classical_Reed-Sternberg_Cell"                                                                                                                                        
[36230] "Abundance_of_Small_Lymphocytes"                                                                                                                                       
[36231] "Defective_Heavy_Chain_Present"                                                                                                                                        
[36232] "Immune_System_Finding"                                                                                                                                                
[36233] "Immunodeficiency"                                                                                                                                                     
[36234] "Negative_Peripheral_Blood"                                                                                                                                            
[36235] "Lung_Inflammatory_Myofibroblastic_Tumor"                                                                                                                              
[36236] "Retroperitoneal_Inflammatory_Myofibroblastic_Tumor"                                                                                                                   
[36237] "Fascicular_Pattern"                                                                                                                                                   
[36238] "Myxoid_Background"                                                                                                                                                    
[36239] "Sparsely_Cellular_Collagenised_Areas_Present"                                                                                                                         
[36240] "Classic_Blastoid_Variant_Mantle_Cell_Lymphoma"                                                                                                                        
[36241] "Pleomorphic_Blastoid_Variant_Mantle_Cell_Lymphoma"                                                                                                                    
[36242] "Lymphoblast-like_Neoplastic_B-Lymphocyte"                                                                                                                             
[36243] "Type_II_Endometrial_Adenocarcinoma"                                                                                                                                   
[36244] "Primary_Glioblastoma"                                                                                                                                                 
[36245] "Secondary_Glioblastoma"                                                                                                                                               
[36246] "Refractory_Disease"                                                                                                                                                   
Slot "definitions":
    [1] "Drug therapy with two or more drugs given separately for a combined effect. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
    [2] "2-mercaptoethanesulfonic acid sodium salt; scavenges glutathione; used as a detoxifying agent for uroprotection (especially in cancer combination chemotherapy), as a prophlylactic for hemorrhagic cystitis, and as an expectorant in treating chronic bronchitis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
    [3] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
    [4] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
    [5] "An anticancer drug that belongs to the family of drugs called antimetabolites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
    [6] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
    [7] "7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
    [8] "A drug that reduces pain and fever (but not inflammation).  It belongs to the family of drugs called analgesics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
    [9] "Acetyl-CoA. Condensation product of coenzyme A and acetic acid; intermediate in transfer of two-carbon fragment, notably in its entrance into the tricarboxylic acid cycle and in fatty acid synthesis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
   [10] "A drug usually used to reduce the thickness of mucus and ease its removal. It is also used to reverse the toxicity of high doses of acetaminophen. Also called N-acetyl-L-cysteine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
   [11] "A naturally occurring component of bacterial cell walls that has the capacity to activate macrophages."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
   [12] "An oligosaccharide anthracycline antineoplastic antibiotic isolated form the bacterium Streptomyces galilaeus.  Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine.  This agent is less cardiotoxic than doxorubicin and daunorubicin. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
   [13] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [14] "A class of chromopeptide antineoplastic antibiotics isolated from the bacterial genus Streptomyces.  Actinomycin antibiotics inhibit DNA replication and RNA and protein synthesis by various mechanisms such as intercalating into the minor groove of DNA or binding to topoisomerase II. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
   [15] "9-(2-hydroxyethoxymethyl) guanine; acts against herpesviruses by inhibiting the viral DNA polymerase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
   [16] "6-aminopurine; one of the 5 major bases (with guanine, thymine, cytosine, and uracil) found in nucleic acids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
   [17] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [18] "The first second-messenger hormone signaling system to be characterized.  cAMP activates a specific protein kinase and is inactivated by phosphodiesterase action giving 5'AMP. (DCB-CB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
   [19] "Adenosine triphosphate.  A substance present in all living cells that provides energy for many metabolic processes and is involved in making RNA.  ATP made in the laboratory is being studied in patients with advanced solid tumors to see if it can decrease weight loss and improve muscle strength."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
   [20] "A drug that stimulates the immune system to respond to disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
   [21] "Hormones that have antitumor activity in lymphomas and lymphoid leukemias; in addition, corticosteroids (steroids) may be used for hormone replacement and for the management of some of the complications of cancer and its treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
   [22] "A purified form of the anterior pituitary hormone Corticotropin that stimulates steroidogenesis, by oxidative cleavage of the cholesterol side chain, and secretion of adrenocortical hormones.  Clinical Use: Adrenal Insufficiency Diagnosis, Multiple Sclerosis-Exacerbations, and Rheumatic Diseases.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
   [23] "(AF-la-TOK-sins) Harmful substances made by certain types of mold (Aspergillus flavus and Aspergillus parasiticus) that are often found on poorly stored grains and nuts. Consumption of foods contaminated with aflatoxins is a risk factor for primary liver cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
   [24] "The main protein in blood plasma. Low levels of serum albumin occur in people with malnutrition, inflammation, and serious liver and kidney disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
   [25] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [26] "A colorless organic liquid also known as ethyl alcohol or grain alcohol.  Ethanol's primary physiologic effects involve the central nervous system.  Depending on the dose delivered, ethanol behaves as an anxiolytic, a depressant, or a general anesthetic.  Ethanol-induced immunosuppression involves dysregulation of CD4+ T cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
   [27] "Methyl alcohol; wood alcohol.  Used as a solvent and as an intermediate in chemical synthesis.  Component of deicing mixtures and preservatives. Toxic."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
   [28] "One of a series of organic chemical compounds of the formula ROH in which a hydrogen (H) attached to carbon is replaced by a hydroxyl (OH)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
   [29] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [30] "An ultra short-acting narcotic analgesic with unknown mechanism of action that binds to the opiate receptors in the central nervous system and changes the perception of and emotional response to pain. It also has local anesthetic effects. Current Use: Pain control and induction of anesthesia. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
   [31] "A member of a large group of chemicals that are made by plants and have nitrogen in them. Some alkaloids have been shown to work against cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [32] "any compound of the type R-SO3-."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [33] "A family of anticancer drugs that interferes with the cell's DNA and inhibits cancer cell growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
   [34] "A a structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
   [35] "A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumour agents.  Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products.  These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element.  The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis), antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation), anticancer effects (interference with oncogene expression), and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04)"                                                 
   [36] "A difluoromethylated ornithine compound with antineoplastic activity.  Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
   [37] "8-chloro-1-methyl-6-phenyl-s-triazolobenzodiazepin e, has both antidepressant and anxiolytic properties; possible efficacy in alcohol withdrawal therapy; abuse can lead to habituation or addication."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
   [38] "A type of immune adjuvant (a substance used to help boost the immune response to a vaccine).  Also called alum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
   [39] "A transuranic man-made radioactive element with atomic symbol Am, atomic number 95, and atomic weight 243. Current Use: Bone mineral analysis and radiation source for radiotherapy (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
   [40] "An antibiotic drug used to treat infection. It belongs to the family of drugs called aminoglycoside antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [41] "Organic compounds containing amino (-NH2) and carboxyl (-COOH) groups.  In biochemistry, used to refer to the twenty-plus L-alpha-amino acids found in proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [42] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [43] "A synthetic derivative of the sedative and anticonvulsant glutethimide with anti-steroid properties.  Originally used as an anticonvulsant, aminoglutethimide also blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone.  In addition, this agent blocks the peripheral aromatization of androgenic precursors to estrogens.  Aminoglutethimide does not suppress ovarian estrogen production. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
   [44] "A drug used in photodynamic therapy that is absorbed by tumor cells; when exposed to light, it becomes active and kills the cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
   [45] "A synthetic derivative of pterins with antineoplastic and immunosuppressive properties.  As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
   [46] "2-butyl-3-(3,5-diiodo-4-beta diethylaminoethoxybenzoyl) benzofuran; coronary vasodilator used as an antiarrhythmic; severe risk of pulmonary and hepatic toxicity via disruption of lysosomal function; also has amphiphilic phototoxin properties."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
   [47] "A broad-spectrum semisynthetic antibiotic, similar to ampicillin but more resistance to gastric acids, that inhibits bacterial cell wall synthesis by binding to penicillin binding proteins and inhibiting peptidoglycan synthesis, a critical component of bacterial cell walls. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
   [48] "A macrolide antifungal antibiotic produced by Streptomyces nodosus that binds to ergosterol altering cell membrane integrity with subsequent cell death. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
   [49] "A broad-spectrum semisynthetic derivative of aminopenicillin that inhibits bacterial cell wall synthesis by binding to penicillin binding proteins and inhibiting peptidoglycan synthesis, a critical component of bacterial cell wall. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
   [50] "A topoisomerase II inhibitor that intercalates with DNA, causing double-strand breaks and cell death. Current Use: Leukemia. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
   [51] "Drugs that reduce pain. These drugs include aspirin, acetaminophen, and ibuprofen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
   [52] "(an-tee-AN-dro-jens) Drugs used to block the production or interfere with the action of male sex hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
   [53] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [54] "A potent androgenic prohormone that is a direct precursor of testosterone and used as a supplement to increase plasma testosterone levels and muscle anabolism. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
   [55] "(an-es-THET-iks) Substances that cause loss of feeling or awareness. Local anesthetics cause loss of feeling in a part of the body. General anesthetics put the person to sleep."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [56] "A drug that may reduce the risk of development or progression of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
   [57] "class of antihypertensive agents which act by inhibiting the proteolytic activation of angiotensin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
   [58] "angiotensin I, an inactive decapeptide, is cleaved by angiotensin converting enzyme to form the octapeptide angiotensin II, a powerful vasopressor, which is then cleaved to the heptapeptide angiotensin III, an aldosterone stimulant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
   [59] "An alkylating antineoplastic agent that covalently adducts DNA and causes cytotoxicity. It has been reported more effective in mice than in humans. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
   [60] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [61] "Anthracene, also called paranaphthalene or green oil, a solid polycyclic aromatic hydrocarbon (PAH) consisting of three benzene rings derived from coal-tar, is the simplest tricyclic aromatic hydrocarbon.  It is on the EPA's priority pollutant list. It is ubiquitous in the environment as a product of incomplete combustion of fossil fuels. It has been identified in surface and drinking water, ambient air, exhaust emissions, smoke of cigarettes and cigars, and in smoked foods and edible aquatic organisms. It is primarily used as an intermediate in the production of dyes, smoke screens, scintillation counter crystals, and in organic semiconductor research. Although a large body of literature exists on the toxicity of PAHs, data for anthracene are limited. Prolonged exposure causes variety of topical and systemic adverse reactions. Carcinogenicity bioassays with anthracene generally gave negative results. (NCI)"                                           
   [62] "A pyrrolo(1,4)benzodiazepine antineoplastic antibiotic isolated from the bacterium Streptomyces refuineus var. thermotolerans.  Anthramycin binds covalently to guanine in the minor groove of DNA, thereby inhibiting DNA replication and RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
   [63] "A subgroup of the family of anticancer drugs called anticancer antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
   [64] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [65] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [66] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [67] "NSAIDs. A group of drugs that decrease fever, swelling, pain, and redness."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
   [68] "(an-tih-by-AH-tik) A drug used to treat infections caused by bacteria and other microorganisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
   [69] "A group of anticancer drugs that block cell growth by interfering with DNA, the genetic material in cells. Also called anticancer antibiotics or antitumor antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
   [70] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [71] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [72] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [73] "A drug that helps prevent blood clots from forming. Also called a blood thinner."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [74] "(an-tee-kon-VUL-sants) Drugs that prevent, reduce, or stop convulsions or seizures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
   [75] "A drug used to treat depression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [76] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [77] "Drugs that prevent or reduce nausea and vomiting."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
   [78] "Any substance that appears foreign or potentially adverse to the body and elicits immune response."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
   [79] "Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
   [80] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [81] "Agents used to treat malaria, and are usually classified based on action against plasmodia at different stages in their life cycle in the human. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
   [82] "A drug that is very similar to natural chemicals in a normal biochemical reaction in cells but different enough to interfere with the normal division and functions of cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
   [83] "Drugs that kill cancer cells by interfering with cell division (mitosis)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
   [84] "A drug used to treat cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
   [85] "A group of organic or inorganic substances capable of preventing the genotoxic and carcinogenic effects of free-radical compounds.  Antioxidants bind to and neutralize ('scavenge') free radicals, thereby transforming them into non-toxic compounds and blocking their genotoxic and carcinogenic effects.  This class of agents includes the vitamins C and E, the carotenoids, and selenium.  Organic antioxidants are found in high concentrations in fruits, seeds and vegetables. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
   [86] "Drugs used to treat bacterial and parasitic infections and some cancers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
   [87] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [88] "(an-tee-THIGH-mo-site GLOB-yoo-lin) A protein used to reduce the risk of or to treat graft-versus-host disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
   [89] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   [90] "Having to do with a drug used to treat tuberculosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
   [91] "Agents used in the prophylaxis or therapy of virus diseases. They may act to prevent viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; blocking late stages of virus assembly; etc. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
   [92] "An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
   [93] "A sweetener is a food additive which duplicates the effect of sugar on the taste, but with fewer calories. They are also called sugar substitutes. (Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
   [94] "(as-BES-tus) A natural material that is made up of tiny fibers. The fibers can cause cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
   [95] "A natural water-soluble vitamin (Vitamin C), Ascorbic Acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and primarily in the formation of collagen in fibrous tissue, teeth, bones, connective tissue, skin, and capillaries. Found in citrus, in other fruits, and in vegetables, vitamin C cannot be produced or stored by humans and must be obtained in the diet. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
   [96] "An enzyme used in the treatment of cancer.  It belongs to the family of drugs called antineoplastics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
   [97] "A drug that reduces pain, fever, inflammation, and blood clotting. Aspirin belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is also being studied in cancer prevention."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
   [98] "An anticancer drug that belongs to the family of drugs called antimetabolites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
   [99] "A naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine analogue (glutamine amidotransferase inhibitor) that competitively inhibits pathways in which glutamine is metabolized. An antibiotic and antitumour agent, Azaserine is used in clinical studies as a potential antineoplastic agent. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [100] "6-(1-Methyl-4-nitro-5-imidazolyl)thiopurine; a derivative of 6-mercaptopurine, used as a cytotoxic and immunosuppressive agent in organ transplantation and in the treatment of autoimmune diseases such as hemolytic anemias, systemic lupus erythematosus, rheumatoid arthritis and leukemias."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [101] "Used as an antineoplastic and antipsoriatic agent, 6-Azauridine is a synthetic derivative with cytostatic properties that result from inhibition of de novo pyrimidine biosynthesis by its metabolite 6-azauridine 5-prime monophosphate and from incorporation of a 5-prime triphosphate metabolite into RNA. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [102] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [103] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [104] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [105] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [106] "A toxic substance, made by bacteria, that can be modified to kill specific tumor cells without harming normal cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [107] "Batrachotoxins are potent activators of sodium channels identified in extract of frog skins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [108] "An active immunizing agent (Bacille Calmette Guerin) against tuberculosis, BCG Vaccine usually contains a viable attenuated avirulent strain of Mycobacterium tuberculosis (var. bovis) that confers immunity to mycobacterial infections. Not widely used in the United States, BCG is often given to children where TB is common. Due to stimulation of antibody production and non-specific immunity, BCG is also used in cancer immunotherapy. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [109] "A drug being studied in the treatment of graft-versus-host disease.  It belongs to a family of drugs called corticosteroids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [110] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [111] "An abnormal plasma or urinary protein, consisting of monoclonal immunoglobulin light chains, excreted in some plasma cell dyscrasias and characterized by its unusual solubility properties. (Dorland, 28th ed, p1368 & p190; Garrison and Morton's Medical Bibliography, 2d ed, p378)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [112] "Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc.  Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [113] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [114] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [115] "(bil-ih-ROO-bun) Substance formed when red blood cells are broken down. Bilirubin is part of the bile, which is made in the liver and is stored in the gallbladder. The abnormal buildup of bilirubin causes jaundice."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [116] "Naturally occurring flavone or coumarin derivatives having the activity of the so-called vitamin P, notably rutin and esculin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [117] "Biotechnology-derived pharmaceutical products.  Includes recombinant proteins, monoclonal antibodies, and nucleic acids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [118] "Substances or procedures that enhance the host's ability to inhibit tumorigenesis or tumor progression or that increase the differential between tumor and host susceptibility to therapeutic agents. Thus BRMs can be preventive (vaccines, vitamins) or therapeutic (interferon, monoclonal antibodies, hyperthermia, gene therapy.) Standard, nonspecific therapies such as drugs and radiation are excluded but radiation delivered via antibodies would be included since it exploits a differential susceptibility of tumor and host."                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [119] "Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid. Growth factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. The biotin content of cancerous tissue is higher than that of normal tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [120] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [121] "The primary bleomycin species in bleomycin sulfate, a mixture of the sulfate salts of several basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus.  Bleomycin A2 forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [122] "A mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus.  Bleomycin sulfate forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [123] "A mixture of glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus.  Bleomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, alteration in prostaglandin synthesis and degradation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [124] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [125] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [126] "A nonapeptide kinin and neuropeptide involved in blood pressure regulation and pain receptor stimulation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [127] "Bromocriptine belongs to the group of medicines known as ergot alkaloids. It acts as a dopamine agonist primarily activating the dopamine D2 receptors. It blocks release of prolactin from the pituitary gland, and is used in the therapy of amenorrhea, infertility in women, abnormal breast milk discharge, hypogonadism, Parkinsons disease, and acromegaly. It is also used in the treatment of pituitary prolactinoma, neuroleptic malignant syndrome, cocaine addiction, and painful breast condition. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [128] "A drug that makes cancer cells more sensitive to radiation and is also used as a diagnostic agent to determine how fast cancer cells grow."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [129] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [130] "A synthetic analog of gonadotropin-releasing hormone (GnRH).  Prolonged administration of buserelin results in sustained inhibition of gonadotropin production, suppression of testicular and ovarian steroidogenesis, and reduced levels of circulating gonadotropin and gonadal steroids. Buserelin is more potent that GnRH. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [131] "A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties.  Although its mechanism of action is not fully understood. busulfan appears to act through the alkylation of DNA.  Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [132] "2,6-di-tert-butyl-4-methylphonol, a perservative commonly used in packaged foods."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [133] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [134] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [135] "A substance sometimes found in an increased amount in the blood, other body fluids, or tissues and that may suggest the presence of some types of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [136] "Mucin is expressed by most glandular epithelia.  Tandem repeats characterize the core mucin protein, apomucin; variation of the protein derives from variation in the number of expressed repeats.  Native forms of mucin are distinct in size and degree of glycosylation; factors other than the primary structure of apomucin may contribute to these characteristics.  Many complex O-linked oligosaccharides are presumably added by glycosyltransferases.  Expression is increased in the lactating breast and in breast, ovary, lung, and prostate malignancies.  It is a serum marker for breast cancer.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                            
  [137] "CA19-9 is a carbohydrate often found in elevated levels in patients with carcinoma of the pancreas or gastrointestinal tract."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [138] "1,3,7-trimethylxanthine, a central stimulant found in coffee and tea; action may be mediated by adenosine receptors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [139] "A hormone formed by the C cells of the thyroid gland. It helps maintain a healthy level of calcium in the blood.  When the calcium level is too high, calcitonin lowers it."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [140] "(kal-sih-TREE-ol) The active form of vitamin D.  Calcitriol is formed in the kidneys or made in the laboratory.  It is used as a drug to increase calcium levels in the body in order to treat skeletal and tissue-related calcium deficiencies caused by kidney or thyroid disorders."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [141] "(KAL-see-um) A mineral found in teeth, bones, and other body tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [142] "A calcium salt with carbonic acid (CaCO3), Calcium Carbonate is used therapeutically as a phosphate buffer in hemodialysis, as an antacid in gastric hyperacidity for temporary relief of indigestion and heartburn, and as a calcium supplement for preventing and treating osteoporosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [143] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [144] "Contracted name for a salt of ethylenediaminetetraacetate, an agent used as a chelator of lead and some other heavy metals. C10H12CaN2Na2O8."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [145] "The calcium salt form of glucarate that converts to D-Glucaro-1,4-Lactone which inhibits beta-Glucuronidase, an enzyme that may prevent carcinogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [146] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [147] "17 beta-OH-7 beta, 17 alpha-dimethyl-androst-4-ene-3-one-dimethyltestosterone. Calusterone is an orally active androgenic anabolic steroid used in antineoplastic therapy, particularly in treatment of advanced breast cancer in post-menopausal patients with osseous and cutaneous lesions. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [148] "4-ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione.  Topoisomerase I inhibitor.  Alkaloid derived from the bark of the tree Camptotheca acuminata.  Exhibits antileukemic and antitumor activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [149] "A component of certain plants, including cayenne and red pepper, used topically for peripheral nerve pain. Also being studied for controlling mucositis pain after chemotherapy and radiation therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [150] "A drug used to lower high blood pressure.  It belongs to the family of drugs called ACE inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [151] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [152] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [153] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [154] "A group of organic compounds consisting of carbon, hydrogen, and oxygen. They form the primary source of energy in animals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [155] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [156] "A bacterial enzyme that belongs to the family of drugs called chemoprotective agents. It is used to neutralize the toxic effects of methotrexate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [157] "(kar-SIN-o-jin) Any substance that causes cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [158] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [159] "An anticancer drug that belongs to the family of drugs called alkylating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [160] "C(40)H(56) terpenoid plant pigment which is transformed into vitamin A in the liver."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [161] "\"Tetraterpenoids (C40), formally derived from the acyclic parent ,-carotene (I) by hydrogenation, dehydrogenation, cyclization, oxidation, or combination of these"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [162] "An anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata.  Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [163] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [164] "A third generation semisynthetic cephalosporin antibiotic that inhibits mucopeptide synthesis by binding to penicillin binding proteins, causing inhibition of bacterial cell wall synthesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [165] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [166] "An antibiotic drug that belongs to the family of drugs called cephalosporins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [167] "A family of antibiotic drugs that is used to treat a wide variety of bacterial infections."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [168] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [169] "A type of fat produced in the body.  It may cause some types of cells to die and is being studied in cancer treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [170] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [171] "Spit tobacco (smokeless tobacco) comes in two forms: snuff and chew.  Users put a pinch of snuff (called a \"dip\" or \"rub\") next to the gum and hold it there.  Chewing tobacco is bulkier than snuff and, as it name suggests, is chewed. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [172] "An anticancer drug that belongs to the family of drugs called alkylating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [173] "Chloromycetin; 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-P-nitrophenethyl)-, D-threo-(-)-acetamide. A primarily bacteriostatic antibiotic with wide spectrum of activity against gram-positive and gram-negative cocci and bacilli, first isolated from cultures of Streptomyces venequelae. It binds to the 50S subunit of the ribosome and inhibits bacterial protein synthesis. Reserved for serious infections caused by organisms susceptible to its antimicrobial effects, especially Hemophilus influenza, Streptococcus pneumonia, and neisseria meningitidis. It is used only when less potentially hazardous therapeutic agents are ineffective or contraindicated, because it rarely causes the potentially lethal complication of aplastic anemia. (NCI)"                                                                                                                                                                                                                      
  [174] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [175] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [176] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [177] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [178] "Secreted by Vibrio cholerae, Cholera Toxin is a natural bacterial enterotoxin consisting of major components heavy A- and light B peptides (choleragenoid) that initiates a signaling cascade in intestinal epithelial cells causing a dysfunction of chloride channels, loss of water, and diarrhea. B peptide anchors the protein to epithelia; A peptide enters the cytoplasm and activates adenylate cyclase. Due to its cytotoxicity, cholera toxin is being studied for tumor cell targeting and cancer chemotherapy. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [179] "The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [180] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [181] "A class of glycosidic antineoplastic antibiotics isolated from the bacterium Streptomyces griseus.  Chromomycin antibiotics bind to the minor groove of DNA, specifically to guanine/cytosine base pairs, and inhibit RNA synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [182] "An extract of Goa powder; a complex mixure of reduction products of chrysophanic acid, emodin, and emodin monomethyl ether; used locally in ringworm, psoriasis, and eczema."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [183] "1,2-Benzphenanthrenes. Polycyclic hydrocarbons obtained from coal tar. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [184] "A drug usually used to treat stomach ulcers and heartburn. It is also commonly used in a regimen to prevent allergic reactions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [185] "A synthetic broad spectrum fluoroquinolone antibiotic. Ciprofloxacin inhibits bacterial DNA gyrase, an enzyme essential for DNA replication.  This agent is more active against Gram-negative bacteria than Gram-positive bacteria. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [186] "An anticancer drug that belongs to the family of drugs called platinum compounds."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [187] "A semisynthetic broad spectrum antibiotic produced by chemical modification of the parent compound lincomycin. Clindamycin dissociates peptidyl-tRNA from the bacterial ribosome, thereby disrupting bacterial protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [188] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [189] "A triphenylethylene nonsteroidal ovulatory stimulant evaluated for antineoplastic activity against breast cancer.  Clomiphene has both estrogenic and anti-estrogenic activities that compete with estrogen for binding at estrogen receptor sites in target tissues.  This agent causes the release of the pituitary gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to ovulation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [190] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [191] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [192] "A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [193] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [194] "A coenzyme containing pantothenic acid, adenosine 3-phosphate 5-pyrophosphate, and cysteamine; involved in the transfer of acyl groups, notably in transacetylations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [195] "inhibits tubulin-tubulin binding and thus destabilizes microtubules; used to block mitosis, axonal transport, and other microtubule dependent cellular functions in vitro, and clinically to treat gout."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [196] "Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally. (Medical Dictionary Online)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [197] "Glycoprotein growth factors produced by monocytes, macrophages, or activated lymphocytes that stimulate the proliferation of bone marrow cells and differentiation of stem cells into colonies of granulocytes, monocytes, or macrophages.  These substances act in either paracrine or autocrine fashion on marrow cells, appear to act synergistically in complex and poorly understood ways.  Each appears to exert actions on several lines of progenitor cells and to influence end cell function.  Treatment with colony-stimulating factors (CSF) can help the blood-forming tissue recover from the effects of chemotherapy and radiation therapy.  These factors include interleukin-3 (IL-3), granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF)."                                                                                                                                
  [198] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [199] "agent taken orally that prevents conception or diminishes its likelihood; may be designed for either male or female."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [200] "A substance that is introduced into or around a structure and, because of the difference in absorption of X-rays by the contrast medium and the surrounding tissues, allows radiographic visualisation of the structure. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [201] "A trace element with atomic number 29 and atomic weight 63 and forms part of enzymes that are involved in biochemical reactions of cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [202] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [203] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [204] "A synthetic form of Corticotropin Releasing Factor, a hypothalamic hormone made up of 41 amino acids, that stimulates the pituitary to release beta-endorphin and corticotropin, causing steroidogenesis and secretion of adrenocortical hormones used to diagnose and treat conditions of the hypothalamic-pituitary-axis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [205] "A corticosteroid having a potent glucocorticoid and a slight mineralocorticoid activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [206] "A cloning vector derived from the bacteriophage lambda.  Such a vector includes at least one cos site, the target for DNA uptake into bacteriophage particles and integration into the host genome.  Cosmid vector can hold larger pieces of foreign DNA (inserts) than plasmids.  Cosmids are maintained as circular molecules.  Inserts are generally limited to less than 50 Kb."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [207] "O hydroxycinnamic acid. Pleasant smelling compound found in many plants and released on wilting (probably a major component of the smell of fresh hay). Has anticoagulant activity by competing with Vitamin K. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [208] "A benzothiazepine calcium channel blocking agent. Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility.  Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [209] "(cree-AT-ih-nin) A compound that is excreted from the body in urine.  Creatinine levels are measured to monitor kidney function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [210] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [211] "A yellow pigment of the spice turmeric that is being studied in cancer prevention."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [212] "reagent which specifically cleaves peptide bonds at methionine residues, used to hydrolyze proteins for peptide mapping and aminoacid and sequence analysis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [213] "A derivative of cytarbine (ara-C).  Although ancitabine's mechanism of action is unclear, it may inhibit DNA polymerase via competitive inhibition of deoxycytidine triphosphatase, resulting in inhibition of DNA replication; this agent may also incorporate into DNA and RNA. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [214] "A synthetic amino acid derivative of cyclopentanecarboxylic acid, Cycloleucine displays immunosuppressive, antineoplastic, and cytostatic properties. Believed to act in vivo as a valine antagonist and an NMDA receptor antagonist acting at the glycine site, Cycloleucine is a competitive inhibitor of many enzymes, such as methionine adenosyltransferase (S-adenosylmethionine biosynthesis). Toxicity is correlated with a block of nucleic acid methylation; cell cycle progression; and DNA, RNA and protein biosynthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [215] "A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.  In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [216] "11-residue cyclic peptide produced by certain fungi which has antifungal and T cell specific immunosuppressive properties."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [217] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [218] "An anticancer drug that belongs to the family of drugs called antimetabolites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [219] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [220] "2-keto-4-aminopyrimidine, one of the 5 major bases (with adenine, guanine, uracil, and thymine) which are a component of nucleic acids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [221] "A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [222] "A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus.  Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [223] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [224] "A synthetic androgen derived from ethinyl testosterone.  Danazol indirectly reduces estrogen production by decreasing pituitary secretion of follicle-stimulating hormone and luteinizing hormone, and binds to sex hormone receptors in target tissues, thereby exhibiting antiestrogenic, anabolic and weakly androgenic effects. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [225] "A synthetic derivative of diamino-sulfone with anti-mycobacterial and anti-malarial properties.  A structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [226] "An iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile.  This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [227] "An iron chelating agent.  Deferoxamine mesylate chelates free iron, and the iron of ferritin and hemosiderin within lysosomes, thereby forming ferrioxamine, a water-soluble chelate that is excreted by the kidneys and in the bile.  This agent does not bind iron readily from transferrin, hemoglobin, myoglobin or cytochromes. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [228] "A synthetic derivative of emetine; used in the treatment of intestinal amoebiasis. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [229] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [230] "A drug that protects healthy tissues from the toxic effects of anticancer drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [231] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [232] "A synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [233] "The d-isomer of the codeine analog of levorphanol. It acts on the medullary cough center to suppress cough but does not have the addictive, analgesic, and sedative effects of codeine and does not produce respiratory depression at usual doses. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [234] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [235] "A bifunctional hexitol derivative with potential antineoplastic activity. Dianhydrogalactitol alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in disruption of DNA function and cell cycle arrest. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [236] "The salt form of diazo compounds, compounds containing the N2 nitrogen attached to only one hydrocarbon, formulated by replacing three hydrogen atoms of the salt of an aryl primary amine by nitrogen having the general structure represented as R-N2X.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [237] "An antibiotic with potential antineoplastic activity.  As an L-glutamine antagonist, diazooxonorleucine inhibits enzymes involved in glutamine metabolism, thereby depleting cells of this essential amino acid. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [238] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [239] "A synthetic nucleoside analogue of deoxyadenosine and a prodrug of didanosine in which the 3' hydroxyl group on the ribose moiety is replaced by a hydrogen atom. Dideoxyadenosine competitively inhibits adenylyl cyclase, thereby reducing levels of cyclic adenosine monophosphate (cAMP). By inhibiting cAMP-mediated gene activation in tumor cells, this agent may retard tumor cell proliferation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [240] "A pyrimidine nucleoside analog with antiviral activity; has been investigated as a treatment for AIDS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [241] "A drug used to treat infection caused by viruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [242] "A sulfhydryl-containing carbamate that is the primary in vivo metabolite of disulfiram. Diethyldithiocarbamate chelates zinc, thereby inhibiting metalloproteinases, thereby preventing the degradation of the extracellular matrix and inhibiting an initial step in cancer metastasis and angiogenesis. A known inhibitor of superoxide dismutase, this agent can either potentiate or protect against cell oxidative damage caused by ionizing radiation, depending on the time of administration. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [243] "(dye-ETH-ul-stil-BES-trol) DES. A synthetic hormone that was prescribed from the early 1940s until 1971 to help women with complications of pregnancy. DES has been linked to an increased risk of clear cell carcinoma of the vagina in daughters of women who used DES. DES may also increase the risk of breast cancer in women who used DES."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [244] "1. Aiding digestion. 2. An agent that favors or assists the process of digestion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [245] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [246] "A drug used to relieve pain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [247] "A colorless liquid that readily dissolves many chemicals and penetrates animal and plant tissues.  It is used in human medicine, veterinary medicine, and pharmaceuticals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [248] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [249] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [250] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [251] "Nitroaromatic compounds containing two nitrogen groups on a phenyl ring used as pharmaceuticals, pesticides, explosives, and comprise a group of environmental pollutants.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [252] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [253] "A family of drugs used to treat osteoporosis and the bone pain caused by some types of cancer. Also called diphosphonates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [254] "A 60 kD single chain protein elaborated by Corynebacterium diphtheriae that causes the sign and symptoms of diphtheria; it can be broken into two unequal fragments, the smaller (A fragment) inhibits protein synthesis and is the lethal moiety that needs the larger (B fragment) for entry into cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [255] "A drug that prevents blood cell clumping and enhances the effectiveness of fluorouracil and other chemotherapeutic agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [256] "A class of oligopeptide antineoplastic antibiotics isolated from the bacterium Streptomyces distallicus.  Distamycin antibiotics bind to the minor groove of DNA, preferentially to adenine-thymine (A-T) rich sequences, thereby inhibiting DNA replication and RNA transcription.  In addition to their antitumor effects, these agents possess antiviral and antiprotozoal activities. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [257] "A drug that slows the metabolism of retinoids, allowing them to act over a longer period of time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [258] "A drug that increases the production of urine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [259] "The molecules inside cells that carry genetic information and pass it from one generation to the next."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [261] "A piece of DNA that has been labeled, usually radioactively or with a fluorescent dye, which is used in hybridization studies.  Applications include Northern and Southern blots, in situ hybridization techniques, and diagnostic tests.  DNA probes can be highly specific or degenerate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [262] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [263] "DNA artificially constructed by combining genes from different organisms or by cloning chemically altered DNA, usually for the purpose of genetic manipulation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [264] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [265] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [266] "An anthracycline antineoplastic antibiotic isolated from the fungus Streptococcus peucetius var. caesius.  Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.  The hydrochloride salt doxorubicin hydrochloride is the therapeutic form of doxorubicin. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [267] "An antibiotic drug used to treat infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [268] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [269] "A drug or substance that treats or prevents or alleviates the symptoms of disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [270] "A chelating agent that forms complexes with transition metals, such as iron and zinc, and with radioisotopes for use as imaging agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [272] "A polypeptide quinoxaline antineoplastic antibiotic isolated from the bacterium Streptomyces echinatus.  Echinomycin intercalates into DNA at two locations simultaneously in a sequence-specific fashion, thereby inhibiting DNA replication and RNA synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [273] "Any product of the metabolism of arachidonic acid, e.g., the prostaglandins, thromboxanes, HETEs, and leukotrienes.  The eicosanoids can collectively mediate almost every aspect of the inflammatory response."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [274] "(eh-LEK-tro-lites) Substances that break up into ions (electrically charged particles) when they are dissolved in body fluids or water.  Some examples are sodium, potassium, chloride, and calcium.  Electrolytes are primarily responsible for the movement of nutrients into cells and the movement of wastes out of cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [276] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [277] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [278] "1-carboxy-3-phenylpropyl-L-alanyl- L-proline (as 1'-ethyl ester, maleate 1:1), is an ACE inhibitor used as an antihypertensive."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [279] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [280] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [281] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [282] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [283] "A sympathomimetic agent interacting with both alpha- and beta-adrenergic receptors, causing cardiac stimulation, vasoconstriction, bronchodilation, blood glucose elevation, and gastrointestinal relaxation.  Clinical Use: Ventricular Fibrillation, Anaphylactic Shock, Asthma, Cardiopulmonary Resuscitation, Glaucoma, and Topical Anesthetic-Adjuvant.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [284] "An anticancer drug that belongs to the family of drugs called antitumor antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [285] "3-membered organic ring structure containing oxygen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [286] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [287] "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein erythropoietin (Epo).  Epo promotes the differentiation and maturation of hematopoietic progenitors into erythrocytes; is a mitogen and a chemoattractant for endothelial cells; stimulates activated and differentiated B-cells and enhances B-cell immunoglobulin production and proliferation; and is hypoxia-inducible. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [288] "A synthetic form of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.  Typically esterified, estradiol derivatives are formulated for oral or parenteral administration.  As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors.  Estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [289] "A combination of the hormone estradiol (an estrogen) and nitrogen mustard (an anticancer drug). Used in the palliative therapy of prostate cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [290] "An orally-active carbamate ester combining 17 beta-estradiol and nor-nitrogen mustard with antineoplastic activity.  Estramustine phosphate sodium binds to microtubule-associated proteins (MAPs) and tubulin, thereby interfering with microtubule dynamics; causing cell cycle arrest; inhibitiing tumor cell proliferation; inducing tumor cell apoptosis; and disrupting nuclear matrix and cell membranes.  Estramustine targets hormone-sensitive prostate cancer cells and exhibits mild estrogenic activity, although this property does not appear to be its primary mechanism of action.  This agent exhibits synergism in combination with other antimicrotubule agents. (NCI04)"                                                                                                                                                                                                                                                                                                       
  [291] "A substance that blocks the activity of estrogens, the family of hormones that promote the development and maintenance of female sex characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [292] "Naturally or synthetically produced, conjugated estrogens contain female sex hormones (estrogen derivatives) that replace estrogen hormone no longer being made by the body, helping to alleviate symptoms of menopause, including osteoporosis. Conjugated estrogen preparations contain purified mixtures of natural estrogens obtained from pregnant mares or plant-derived estrogens synthesized from steroids. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [293] "A class of natural or synthetic hormones that binds to a cytoplasmic receptor and initiates translocation of the hormone-receptor complex to the nucleus of target cells of tissues rich in estrogen receptors, including the endometrium, myometrium, oviduct, vagina, fallopian tube, cervix, brain, liver, placenta, ovarian cells, Leydigs cells, kidney, prostate, pancreas, heart, and skin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [294] "A class of substances either naturally or synthetically derived forms of estrone.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [295] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [296] "A semisynthetic estrogen. Ethinyl estradiol binds to the estrogen receptor complex and enters the nucleus, activating DNA transcription of genes involved in estrogenic cellular responses. This agent also inhibits 5-alpha reductase in epididymal tissue, which lowers testosterone levels and may delay progression of prostatic cancer. In addition to its antineoplastic effects, ethinyl estradiol protects against osteoporosis. In animal models, short-term therapy with this agent has been shown to provide long-term protection against breast cancer, mimicking the antitumor effects of pregnancy. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                          
  [297] "A synthetic preparation containing the ethyl ester of iodinated fatty acid from poppyseed oil, Ethiodized Oil contains 37% organically bound iodine and is used as a diagnostic radiopaque medium or (with I-131) as an antineoplastic agent. Selectively retained in tumor vessels for long periods, Ethiodol is used for imaging organs such as liver, lung, stomach, and thyroid. Labeled with I-131 or other beta emitters (Y-90 or P-32), ethiodol can deliver a high internal radiation dose to certain tumors with a small effect on healthy tissues. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                               
  [298] "A drug used as a chemoprotective drug to control some of the side effects of chemotherapy and radiation therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [299] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [300] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [301] "A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum.  Possessing potent antineoplastic properties, etoposide inhibits the ability of topoisomerase II to ligate cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [302] "A major component of fats that are used by the body for energy and tissue development."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [303] "A type of fat obtained in the diet and involved in immunity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [304] "A narcotic opioid drug that is used in the treatment of pain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [305] "One of a number of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumour agents. Endogenous interferons beta are cytokines produced by nucleated cells (predominantly natural killer cells) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products.  These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes with an interferon-specific response element.  The proteins so produced mediate many complex effects, including antiviral (the most important being inhibition of viral protein synthesis), antiproliferative and immune modulating effects.  The recombinant therapeutic forms of interferon beta are interferon beta 1-a and interferon beta 1-b. (NCI04)"                                                                                                                                                                                                   
  [306] "Family of structurally related polypeptides which have important roles in cell development, differentiation, and motility, as well as angiogenesis, neurogenesis, wound healing, and tumor growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [307] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [308] "Agents employed in the preparation of histologic or pathologic specimens for the purpose of maintaining the existing form and structure of all of the constituent elements."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [309] "A drug that is used to treat abnormal heart rhythms. It may also relieve neuropathic pain, the burning, stabbing, or stinging pain that may arise from damage to nerves caused by some types of cancer or cancer treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [310] "A drug that treats infections caused by fungi."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [311] "A drug that treats infections caused by fungi."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [312] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [313] "Any fluorescent dye used to label or stain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [314] "A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthetase, resulting in disruption of DNA synthesis and cytotoxicity.  This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [315] "(floor-o-YOOR-a-sil) An anticancer drug that belongs to the family of drugs called antimetabolites.  Also called 5-FU."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [316] "A drug used to treat depression.  It belongs to the family of drugs called antidepressants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [317] "A halogenated derivative of 17-alpha-methyltestosterone.  Similar to testosterone, fluoxymesterone binds to and activates specific nuclear receptors, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus.  This agent also may competitively inhibit prolactin receptors and estrogen receptors, thereby inhibiting the growth of hormone-dependent tumor lines. Fluoxymesterone is approximately five times more potent than methyltestosterone. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [318] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [319] "A toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide.  Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone activity at androgen receptors and inhibit androgen uptake into target cells.  This agent also decreases intraprostatic androgen receptors which prevents translocation of the androgen receptor complex into cellular nuclei, resulting in an inhibition of androgen-dependent DNA and protein synthesis and tumor cell growth arrest and/or transient tumor regression. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                    
  [320] "A B-complex vitamin that is being studied as a cancer prevention agent. Also called folate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [321] "A substance that blocks the activity of folic acid. Folate antagonists are used to treat cancer. Also called antifolate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [322] "Highly reactive chemicals that often contain oxygen and are produced when molecules are split to give products that have unpaired electrons. This process is called oxidation. Free radicals can damage important cellular molecules such as DNA or lipids or other parts of the cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [323] "An anticancer drug that belongs to the family of drugs called antimetabolites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [324] "Drugs that treat infections caused by fungi."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [325] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [326] "A glycosphingolipid cell surface antigen expressed by various tumor cells used in Vaccine Therapy to induce IgM antibody response to GM2.  A defect in catabolism of Ganglioside GM2 leads to neurodegenerative diseases, including Tay-Sach's and Sandhoff Disease.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [327] "A synthetic guanine derivative with antiviral activity.  The active metabolite of ganciclovir, ganciclovir-5-triphosphate (ganciclovir-TP), inhibits DNA replication in herpes viruses. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [328] "A complex molecule that contains both lipids (fats) and carbohydrates (sugars) and is found in the plasma (outer) membrane of many kinds of cells.  Several different types of gangliosides have been identified."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [329] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [330] "The recombinant form of the endogenous polypeptide hormone Glucagon consisting of 29 amino acids responsible for the release of stored glucose, causing increased blood glucose levels.  Clinical Use: Diagnostic Aid for Imaging Studies and Hypoglycemia.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [331] "Synthetically derived forms of the naturally occurring Glucocorticoids.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [332] "An amino acid used in nutrition therapy. It is also being studied for the treatment of diarrhea caused by radiation therapy to the pelvis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [333] "A tripeptide present in most cells comprised of three amino acids (cysteine, glutamic acid, and glycine) acting as an antioxidant, enhancing free radical scavenging, a detoxifying agent, binding to and transforming chemicals into excretable forms, a co-factor for some enzymes, and to boost the immune system.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [334] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [335] "Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups.  In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are resulted from gene recombinations between GYPA and GYPB. (from RefSeq)"                                                                                                                                                                                                                                                                                                                                                                                                     
  [336] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [337] "A class of formulated therapeutic analogs of the endogenous gonadotropin that stimulates or promotes the function of the gonads.  Therapeutic gonadotropins are derived from animal or recombinant sources.  Gonadotropins include follicle-stimulating hormone, luteinizing hormone and chorionic gonadotropin.  These agents stimulate discrete cellular components of the gonads, exerting effects in both males and females. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [338] "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein hormone human chorionic gonadotropin (HCG).  HCG binds to cells of the corpus luteum, thereby stimulating progesterone production and helping to maintain a secretory endometrium. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [339] "An anticancer drug extracted from the cotton plant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [340] "Formulated therapeutic proteins that are either isolated from endogenous sources or manufactured in a laboratory.  Growth factors bind to specific receptors expressed by various cell types, thereby stimulating cell differentiation and/or proliferation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [341] "A cytostatic triazole derivative antimetabolite. Guanazole scavenges tyrosine free radicals, thereby inhibiting mammalian ribonucleotide reductase activity and DNA synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [342] "A purine base that is a constituent of nucleotides occuring in nucleic acids.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [343] "A purine nucleoside formed from a beta-N9-glycosidic bond between guanine and a ribose ring and is essential for metabolism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [344] "A cellular regulatory agent that acts as a second messenger.  Its levels increase in response to a variety of signals (acetylcholine, insulin, oxytocin) and activates specific protein kinases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [345] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [346] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [347] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [348] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [349] "A drug that helps prevent blood clots from forming. It belongs to the family of drugs called anticoagulants (blood thinners)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [350] "Heparitin Sulfate.  A glycosaminoglycan, structurally similar to heparin but with more N-acetyl groups and fewer O- and N-sulfate groups. Occurs in the liver, aorta, and lung.  Accumulates in several mucopolysaccharidoses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [351] "A chemical that kills plants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [352] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [353] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [354] "A synthetic cytoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity.  Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [355] "A synthetic hydrogenated derivative of diethylstilbestrol (DES). Hexestrol exhibits strong affinity for estrogen receptors that are overexpressed in some types of cancers.  When conjugated with a neoplastic drug, hexestrol may selectively concentrate the cytotoxic agent in estrogen receptor-rich tumors.  This agent may also be mutagenic. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [356] "A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis. (MSH2000)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [357] "Substances that inhibit or antagonize the function of the endocrine glands, the biosynthesis or biological effect of secreted hormones.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [358] "Treatment that adds, blocks, or removes hormones.  For certain conditions (such as diabetes or menopause), hormones are given to adjust low hormone levels.  To slow or stop the growth of certain cancers (such as prostate and breast cancer), hormones may be given to block the body's natural hormones.  Sometimes surgery is needed to remove the source of hormones.  Also called hormone therapy, hormonal therapy, or endocrine therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [359] "A glucosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units that is a component of connective tissue, skin, vitreous humour, umbilical cord, synovial fluid and the capsule of certain microorganisms contributing to adhesion, elasticity, and viscosity of extracellular substances."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [360] "A thioxanthene derivative of lucanthone with anti-schistosomal activity and potential antineoplastic activity. Hycanthone interferes with parasite nerve function, resulting in parasite paralysis and death.  This agent also intercalates into DNA and inhibits RNA synthesis in vitro. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [361] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [362] "A group of organic compounds that consist of only hydrogen (H) and carbon (C) atoms and are involved in energy production. They may be cyclic or non-cyclic compounds. They may have double bonds, single bonds or both with carbon forming the backbone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [363] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [364] "Compounds consisting of carbon, hydrogen, and one or more halogen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [365] "A drug used to relieve the symptoms of certain hormone shortages and to suppress an immune response."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [366] "A group of weak acids with the general chemical formula RC(=O)N(R')OH and antineoplastic and antimicrobial activities.  Hydroxamic acids covalently bind to the zinc(II) ion in the active sites of matrix metalloproteinases (MMP), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [367] "A substance that decreases immune responses in the body.  It is used to treat some autoimmune diseases, and is being studied as a treatment for graft-versus-host disease. Hydroxychloroquine belongs to the family of drugs called antiprotozoals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [368] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [369] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [370] "A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleotide reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle.  This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [371] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [372] "A semisynthetic anthracycline antineoplastic antibiotic derived from daunorubicin.  Idarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  Due to its high lipophilicity, idarubicin penetrates cell membranes better than other anthracycline antibiotics.  Idarubicin hydrochloride is the therapeutic form of this drug. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [373] "A drug that reduces the risk of cancer cell growth by interfering with the cells' DNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [374] "A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication.  This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [375] "IgA is the immunoglobulin subclass that is associated with antibody-mediated mucosal immunity.  It is secreted as dimers into the mucosa and is the most effective isotype at fixing complement by the alternative pathway, even though it lacks the ability to fix complement by the classical pathway. There are two subtypes in the human - IgA1 and IgA2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [376] "An immunoglobulin isotype (subclass).  This isotype is expressed on naive B cells along with IgM.  Little is known about its physiologic role."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [377] "An immunoglobulin isotype (subclass).  This isotype has the unique ability to bind with high affinity to IgE receptors (FceRI) on mast cells and basophils and induce degranulation and cytokine production by these cells when they are crosslinked by antigen.  In addition to a central role in atopy and allergic responses, it has been speculated that IgE-mediated mast cell degranulation, by its release of mediators that increase vascular permeability, has an important role in the initiation of immune response in general."                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [378] "An immunoglobulin isotype (subclass) that characterizes secondary immune responses.  This isotype is further broken down into several smaller subclasses (IgG1, IgG2a, IgG2b, IgG3 in the mouse; IgG1-4 in the human), and each subclass is differentially synthesized and secreted into the serum upon differential immune stimuli."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [379] "The major immunoglobulin secreted during a primary immune response.  IgM binds with low affinity but high avidity (multiple binding sites) because it not only occurs as monomers but also as pentamers and hexamers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [380] "An antibiotic drug used to treat severe or very resistant infection. It belongs to the family of drugs called carbapenems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [381] "A blood serum or immunoglobulin fraction that contains antibodies against specific antigens obtained from previously immunized animals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [382] "A protein that acts as an antibody."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [383] "Immunoglobulin containing a transmembrane region and expressed on the plasma membrane of a B cell.  Contrast with secreted Ig which has no transmembrane region but which can still be bound to the cell surface via Fc receptors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [384] "Describes the ability to lower immune system responses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [385] "Agents comprised of various toxic molecules (Radioactive Isotopes and Bacterial or Plant Toxins) conjugated with specific immune substances (Immunoglobulins, Monoclonal Antibodies, and Antigens)that targets affected cells allowing incorporation of the toxin into the cells.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [386] "A drug that belongs to the family of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Indomethacin reduces pain, fever, swelling, and redness. It is also being used to reduce tumor-induced suppression of the immune system and to increase the effectiveness of anticancer drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [387] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [388] "Recombinant therapeutic agents chemically identical to or similar to endogenous glycoproteins which inhibit pituitary production of follicle-stimulating hormone (FSH).  Inhibins, designated as inhibin A and inhibin B, are secreted by the gonads and contribute to the control of gametogenesis, embryonic and fetal development and hematopoiesis.  As members of the transforming growth factor-B super family, the inhibins consist of dimers of two dissimilar protein subunits. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [389] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [390] "Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [391] "A synthetically- or animal-derived form of insulin used in the treatment of diabetes mellitus.  Therapeutic insulin is formulated to be short-, intermediate- and long-acting in order to individualize an insulin regimen according to individual differences in glucose and insulin metabolism.  Long-acting insulins are administered to complement short-acting insulins administered at mealtimes.  These agents may be derived from porcine, bovine or recombinant sources.  Endogenous human insulin, a pancreatic hormone composed of two polypeptide chains, is important for the normal metabolism of carbohydrates, proteins and fats; it has anabolic effects on many types of tissues. (NCI04)"                                                                                                                                                                                                                                                                                        
  [392] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [393] "Interferon gamma (IFNg) is produced by activated T lymphocytes in response to either specific antigen or mitogenic stimulation and is an important immunoregulatory molecule, particularly in allergic diseases.  IFNg activates NK cells, cytotoxic T cells, endothelial cells, and macrophages.  It stimulates LAK activity, costimulates B cell proliferation, inhibits T cell proliferation.  The major interferon produced by mitogenically or antigenically stimulated lymphocytes.  It is structurally different from type I interferon and its major activity is immunoregulation.  It has been implicated in the aberrant expression of MHC II antigens in cells that do not normally produce them, leading to autoimmune disease.  (MSH98)"                                                                                                                                                                                                                                               
  [394] "A group of therapeutic peptide cytokines possessing antiviral, anti-proliferative, and immune modulating effects.  Their endogenous counterparts are cytokines produced after introduction of foreign substances (viruses and bacteria) into the body.  Interferons bind to specific cell-surface receptors, leading to the transcription and translation of genes with an interferon-specific response element.  The resultant proteins mediate many complex effects, ultimately leading to inhibition of viral protein synthesis and cellular growth, alteration of cellular differentiation, interference with oncogene expression, activation of natural killer cells, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity. (NCI04)"                                                                                                                                                                                                      
  [395] "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous protein cytokine interleukin 1 (IL-1)-beta. Produced by monocytes and activated macrophages, endogenous mature IL-1 is generated by proteolytic cleavage by proteases such as IL-1-beta converting enzyme (ICE).  This agent promotes angiogenesis, fibroblast proliferation, and neutrophil chemotaxis; it also regulates the functions of lymphocytes and epithelial cells and is involved in the 'acute phase response' to infection. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [396] "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-1 (IL-1). Produced mainly by monocytes, endogenous IL-1 plays a role in hematopoiesis, is a potent stimulator of T-cell activity, may promote or inhibit tumor growth, depending on tumor type. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [397] "(in-ter-LOO-kin) IL-2. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease) that stimulates the growth of certain disease-fighting blood cells in the immune system. These substances are normally produced by the body. Aldesleukin is IL-2 that is made in the laboratory for use in treating cancer and other diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [398] "Interleukin-3. A type of biological response modifier (a substance that can improve the body's natural response to disease) that enhances the immune system's ability to fight tumor cells. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [399] "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-4 (IL-4). Produced primarily by activated T-cells, IL-4 stimulates the proliferation and differentiation of activated B-cells, and enhances their ability to present antigens to T-cells.  As a potential immunotherapeutic agent, recombinant IL-4 also augments the effects of other cytokines on dendritic cells (DC), cytotoxic T lymphocytes (CTL), and tumor-infiltrating lymphocytes (TIL). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [400] "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-5 (IL-5).  Produced by T cells, IL-5 stimulates the growth, differentiation, and activation of eosinophils, and promotes the conversion of B-cells into antibody- producing cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [401] "A recombinant agent which is chemically identical to or similar to the endogenous proinflammatory cytokine interleukin-6 (IL-6). IL-6 stimulates proangiogenic vascular endothelial growth factor (VEGF) production.  High serum levels of interleukin-6 may indicate recurrence, metastasis, or progression in various cancers and may indicate drug and apoptotic resistance of tumor cells in vitro. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [402] "A recombinant form of Interleukin-7 (IL-7), produced by bone marrow, thymic stromal, and spleen cells and is a hematopoietic growth factor for progenitor B cells and T cells, stimulating proliferation and differentiation of mature T-cells and Natural Killer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [403] "Formulated therapeutic analogs of one of a number of endogenous cytokine interleukins.  Produced by T cells, macrophages, and other cells, interleukins bind to a specific surface receptor on immunohematopoietic cells, thereby inducing a multitude of biologic effects including stimulation of growth, differentiation, and proliferation of lymphocytes and eosinophils; activation of lymphocytes and macrophages; enhancement of mast cell activity; activation of the acute phase response; and stimulation of hematopoiesis.  Some interleukins may enhance the host's immune response to malignant cells by stimulating lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL), which are capable of lysing some tumor cells. (NCI04)"                                                                                                                                                                                                                         
  [404] "An element that is necessary for the body to make thyroid hormone.  It is found in shellfish and iodized salt."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [405] "An iodinated tyrosine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [406] "An antibiotic drug used to treat infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [407] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [408] "A metallic element with atomic number 26 and atomic weight 55.85 that forms part of hemoglobin and other enzyme systems essential for energy metabolism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [409] "Plant compounds that are found in soy products. Soy isoflavones are being studied to see if they help prevent cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [410] "A synthetic derivative of nicotinic acid with anti-mycobacterial properties.  Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6.  Resistance occurs due to decreased bacterial wall penetration. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [411] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [412] "Isopropyl alcohol; n-propan-2-ol; 2-propanol.  Rubbing alcohol; solvent used for cosmetics and pharmacologicals, also as an antiseptic."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [413] "A drug that belongs to the family of drugs called retinoids. It is used in the treatment of acne and psoriasis and is being studied in cancer prevention. Also called isotretinoin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [414] "3-(2-(4-(p-fluorobenzoyl)-piperidino) ethyl)-2,4-quinazolinedione."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [415] "1-acetyl-4-(2,4-dichlorophenyl-2-imidazolylmethyl- 1,3- dioxolanylmethoxyphenyl) piperazine; broad spectrum, oral antifungal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [416] "Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring (IUPAC)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [417] "A drug used to protect normal cells from high doses of the anticancer drug methotrexate. It is also used to increase the antitumor effects of fluorouracil and tegafur-uracil, an oral treatment alternative to intravenous fluorouracil."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [418] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [419] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [420] "An anthelmintic drug. Co-administered with fluorouracil in the treatment of Dukes' stage C colon cancer, levamisole restores immune function through stimulating antibody formation, enhancing T-cell activity, and potentiating macrophage function. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [421] "naturally occuring form of DOPA and precursor of dopamine; used as an antiparkinsonian agent; unlike dopamine it can be administered orally."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [422] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [423] "A synthetic Luteinizing Hormone Releasing Hormone that binds to specific transmembrane glycoprotein receptors on gonadotrophic cells, stimulating synthesis and secretion of gonadotropins.  Continuous administration of Gonadorelin desensitizes the gonadotrophic cells.  Clinical Use: Hypothalamic Amenorrhea and Hypothalamic/Pituitary Function Evaluation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [424] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [425] "A polyunsaturated essential fatty acid found mostly in plant oils. It is used in the biosynthesis of prostaglandins and cell membranes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [426] "A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, sterols, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [427] "An anticancer drug that belongs to the family of drugs called alkylating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [428] "A synthetic agent chemically related to the opiates with anti-diarrheal properties.  Loperamide decreases gastro-intestinal motility by effects on the circular and longitudinal muscles of the intestine. Part of its anti-diarrheal effect may be due to a reduction of gastro-intestinal secretion produced by opioid receptor binding in the intestinal mucosa. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [429] "7-chloro-5-(2-chlorophenyl)-1, 3-dihydro-3-hydroxy-1,4- benzodiazepin-2-one."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [430] "HMG coA reductase inhibitor which inhibits cholesterol biosynthesis and thus lowers blood cholesterol levels; also blocks isoprenylation of protein CAAX motifs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [431] "A type of cytokine produced by lymphocytes for therapeutic use involving celular immunity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [432] "A recombinant agent, which is chemically identical to or similar to the endogenous cytokine tumor necrosis factor-beta (TNF-beta). Produced predominantly by T-lymphocytes and leukocytes, TNF-beta is cytolytic or cytostatic for many tumor cells, and can inhibit the growth of endothelial cells, resulting in an antiangiogenic effect. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [433] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [434] "Manganese. A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [435] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [436] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [437] "An anticancer drug that belongs to the family of drugs called alkylating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [438] "A nitrogen mustard alkylating agent that causes DNA cross linkages. It is a known carcinogen especially in mice. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [439] "A hormonal anticancer drug that is also used in cancer prevention. It belongs to the family of drugs called progestins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [440] "A drug that belongs to the group of hormones called progestins, used as hormone therapy to block estrogen and to suppress the effects of estrogen and androgens. It is also used to stimulate the appetite in people with cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [441] "(MEL-a-nin) The substance that gives color to skin and eyes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [442] "5-methoxy-N-acetyltryptamine, a pineal hormone involved in modulation of skin pigmentation, gonad development, and circadian rhythms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [443] "4-bis-(2-chloroethyl)amino-L-phenylalanine; a bifunctional alkylating agent used as a DNA strand crosslinker and antineoplastic."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [444] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [445] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [446] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [447] "RAEB: Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [448] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [449] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [450] "A sedative, hypnotic agent that was used for insomnia, but was taken off of the market, in the U.S., in 1983 due to its high risk of abuse.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [451] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [452] "An anticancer drug that belongs to the family of drugs called antimetabolites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [453] "A drug used in ultraviolet light therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [454] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [455] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [456] "A drug that is a central nervous system stimulant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [457] "A corticosteroid hormone replacement."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [458] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [459] "A drug that prevents or reduces nausea and vomiting."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [460] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [461] "A drug used to treat bacterial, fungal, and parasitic infections. It is also being studied in the treatment of some cancers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [462] "antiarrhythmia agent pharmacologically similar to lidocaine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [463] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [464] "8-chloro-6-(2-fluorophenyl)-1-methyl- 4H- imidazo(1,5a)(1,4)benzodiazepine; short acting benzodiazepine sedative with high liability for abuse; used for preanesthesia sedation (USP lists as an injectable anesthetic)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [465] "11-((4-dimethylamino) phenyl)-17-hydroxy-17-(1-propynyl) estra-4,9- dien-3-one; progesterone and glucocorticoid antagonist with potential applications in terminating pregnancy, controlling menstruation, and treating hypercortisolism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [466] "A nutrient required to maintain health."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [467] "1-(alpha-methoxymethyl ethanol)-2-nitroimidazole; trichimonicide and experimental mutagen and radiosensitizer, probably due to its ability to form DNA-attacking free radical under hypoxic conditions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [468] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [469] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [470] "Mitogen; a substance which is able to induce mitosis of certain eukaryotic cells. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [471] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [472] "A synthetic derivative of hexitol with antineoplastic and radiosensitizing properties.  Mitolactol alkylates DNA via actual or derived epoxide groups, resulting in inhibition of DNA and RNA synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [473] "A class of methylazirinopyrroloindoledione antineoplastic antibiotics isolated from various Streptomyces bacterial species.  Bioactivated mitomycin antibiotics generate oxygen radicals and alkylate DNA, forming interstrand cross-links and inhibiting DNA synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [474] "A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties.  Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [475] "1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl) -amino) ethyl)amino) anthraquinone; cytotoxic compound with potentially therapeutic antitumor activity in breast cancer, lymphoma, and leukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [476] "A metallic essential trace element with atomic number of 42, and atomic weight of 95.94. Molybdenum (Mo) is a cofactor of various enzymes including xanthine oxidase, aldehyde oxidase, and nitrate reductase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [477] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [478] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [479] "A controlled-release morphine product for severe cancer pain"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [480] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [481] "A sulfur mustard vesicant that had application in chemical warfare, treatment of psoriasis and has been studied as an alkylating agent in cancer therapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [482] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [483] "An antineoplastic antibiotic derived from various Penicillium fungal species.  Mycophenolic acid is an active metabolite of the prodrug mycophenolate mofetil.  Mycophenolic acid inhibits inosine monophosphate dehydrogenase (IMPDH), preventing the formation of guanosine monophosphate and synthesis of lymphocyte DNA that results in inhibition of lymphocyte proliferation, antibody production, cellular adhesion, and migration of T and B lymphocytes.  Mycophenolic acid also has antibacterial, antifungal, and antiviral activities. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [484] "Mycotoxins are toxic, secondary metabolites of low molecular weight produced by naturally occurring fungi.  Mycotoxins are neither infectious nor contagious, but can occur on a herd-wide basis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [485] "Nicotinamide Adenine Dinucleotide, a coenzyme, found in eukaryotic cells and is involved in many enzymatic reactions and the production of energy through redox reactions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [486] "Nicotinamide Adenine Dinucleotide Phosphate, an oxidation-reduction coenzyme, found in eukaryotic cells and is involved in many enzymatic reactions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [487] "A triphenylethylene nonsteroidal agent that acts as a partial estrogen antagonist.  Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors.  This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue.  Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [488] "A substance that is being studied as a treatment for constipation caused by narcotic medications.  It belongs to the family of drugs called narcotic antagonists."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [489] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [490] "6-methoxy-alpha-methyl-2-naphthaleneacetic acid; nonsteroidal antiinflammatory drug (NSAID); acts by inhibiting cyclooxygenase and thus prostaglandin synthesis; tocolytic oxytocin antagonist."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [491] "class of drugs used to treat opiate drug addiction."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [492] "An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore.  Zinostatin is isolated from the bacterium Streptomyces carzinostaticus.  The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [493] "Antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C. It acts by inhibiting translation during protein synthesis. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [494] "first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons; comprised of alpha, beta, and gamma subunits; beta subunit is responsible for its growth stimulating activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [495] "Encoded by single copy human NPY Gene (NPY Family), 97-aa 11-kDa (precursor) secreted Neuropeptide Y is a 36-aa peptide neuromodulator with sequence homology to peptide YY and PNP. One of the most abundant widespread peptides in the nervous system and found in some adrenal medulla chromaffin cells, NPY is one of the most highly conserved peptides known; only 3 amino acid differences exist between human and shark. Implicated in control of feeding, energy balance, and secretion of GNRH, NPY may also regulate angiogenesis. NPY regulates proliferation of multipotent postnatal neuronal precursor or basal cells by PKC-dependent rapid and transient activation of ERK1/2 MAP kinases (via NPY Y1 receptor subtype). (NCI)"                                                                                                                                                                                                                                                    
  [496] "A member of a class of protein-like molecules made in the brain. Neuropeptides consist of short chains of amino acids, with some functioning as neurotransmitters and some functioning as hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [497] "Endogenous signaling molecules that alter the behavior of neurons or effector cells. Neurotransmitter is used here in its most general sense, including not only messengers that act directly to regulate ion channels, but also those that act through second messenger systems, and those that act at a distance from their site of release. Included are neuromodulators, neuroregulators, neuromediators, and neurohumors, whether or not acting at synapses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [498] "A substance that is poisonous to nerve tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [499] "Water-soluble vitamin of the B complex occurring in various animal and plant tissues. Required by the body for the formation of coenzymes NAD and NADP. Has pellagra-curative, vasodilating, and antilipemic properties."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [500] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [501] "An addictive CNS stimulant found in the tobacco plant that causes either ganglionic stimulation by depolarization in low doses or ganglionic blockage in high doses. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [502] "1,4 dihydropyridine; centrally acting calcium channel blocker used in the treatment of a wide range of disorders, including drug withdrawal, AIDS motor/cognitive disorder, and post cardiac surgery recovery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [503] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [504] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [505] "An unstable free-radical gas which reacts rapidly with oxygen to form nitrogen oxides.  Water soluble, NO is produced normally in numerous tissues and is considered to be a mediator of cell-to cell communication; it functions in numerous processes including vasodilation, inflammation, and neurotransmission. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [506] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [507] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [508] "RAEB: A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [509] "(nye-TRO-so-yoo-REE-ahz) A group of anticancer drugs that can cross the blood-brain barrier. Carmustine and lomustine are nitrosoureas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [510] "An anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces nogalater.  Nogalamycin intercalates into DNA and interacts with topoisomerase I, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [511] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [512] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [513] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [515] "An antibiotic drug used to treat infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [516] "A family of macromolecules, composed of various moiety: purines, pyrimidines, phosphoric acid, and a pentose, either d-ribose or d-deoxyribose. Nucleic acids in the form either DNA or RNA was found in the chromosomes, nucleoli, mitochondria, and cytoplasm of all cells, and in viruses.  Nucleic acids are the major players in controlling cellular function and heredity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [517] "The constituent purine or pyrimidine bases of DNA or RNA with their corresponding deoxyribose or ribose sugars."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [518] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [519] "nucleoside phosphates, the building blocks of nucleic acids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [520] "A drug that treats infections caused by fungi."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [521] "A drug similar to the naturally occurring growth hormone inhibitor somatostatin. Octreotide is used to treat diarrhea and flushing associated with certain types of tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [522] "An antibiotic drug used to treat infection. It belongs to the family of drugs called quinolone antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [523] "Polymers made up of a few (2-20) nucleotides."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [524] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [526] "A drug that inhibits gastric acid secretion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [527] "Manipulated or engineered viruses having oncolytic properties to selectively replicate in and kill targeted cancer cells, leaving normal cells unharmed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [528] "A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [529] "A class of metal-containing organic compounds, where a C atom is joined directly to the metal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [531] "OxyContin's active ingredient is oxycodone, a morphine-like substance that is also found in drugs like Percodan and Tylox. OxyContin Tablets are administered chronically to patients with cancer-related pain in a usual clinical setting."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [532] "One of the components of air (21%), with atomic symbol O, when combines with hydrogen it forms H2O - water."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [534] "A synthetic form of a natural posterior pituitary hormone that stimulates uterine smooth muscle contractions and mammary glands to cause ejection of milk. Current Use: Postpartum Hemorrhage and Placental Delivery. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [535] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [536] "An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically.  As a direct-acting smooth muscle relaxant, papaverine is not closely related to the other opium alkaloids in structure or pharmacological actions; its mechanism of action may involve the non-selective inhibition of phosphodiesterases and direct inhibition of calcium channels. This agent exhibits antiviral activity against respiratory syncytial virus, cytomegalovirus, and HIV.  (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [537] "Paraffin is a common name for a group of high molecular weight alkane hydrocarbons with the general formula CnH2n+2, where n is between 22 and 27. Paraffin is also a technical name for an alkane in general, but in most cases it refers specifically to a linear, or normal alkane. It is mostly found as a white, odorless, tasteless, waxy solid, with a melting point between 47C and 65C. It is insoluble in water, but soluble in ether, benzene, and certain esters. Paraffin is unaffected by most common chemical reagents but oxidizes readily. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                       
  [538] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [539] "A beta dimethyl analog of the amino acid cysteine.  As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion.  Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [540] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [541] "4,4-diamidino-alpha,omega-dephenoxypentane (HCl); effective against Pneumocystis carinii, a cause of AIDS related pneumonia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [542] "An anticancer drug that belongs to the family of drugs called antimetabolites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [543] "A drug used to prevent blood clotting and as a treatment that may help decrease weight loss in people with cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [544] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [545] "Any compound consisting of two or more amino acids, the building blocks of proteins. Peptides are combined to make proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [546] "Any of various biologically active proteins or toxins elaborated by Bordetella pertussis that cause the symptoms of whooping cough. Some activate pancreatic islets, others inhibit the adenylate cyclase cascade and some cause lymphocytosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [547] "General term for an agent that destroys fungi, insects, rodents, or any other pest. RAEB: Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL), INSECTICIDES, RODENTICIDES, etc. (MSH99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [548] "Phencyclidine (PCP) was developed as an anesthetic for humans in 1959. Its use was discontinued due to extreme side effects that included delirium, confusion, visual disturbances, hallucinations and violence. Some evidence of long-term memory disorders and schizophrenia-like syndrome have been observed. It is a substance of abuse, combining effects produced by depressants, stimulants, and hallucinogens. Can cause physical and psychological distress, coma, seizures and convulsions, respiratory depression, and cardiac problems. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [549] "A sedative/anticonvulsant barbiturate that has been used to treat diarrhea and to increase the antitumor effect of other therapies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [550] "3-ring structure of two benzene rings joined by a sulfur and a nitrogen atom; an important class of antipsychotic and other drugs which act by disrupting monoamine transmitter systems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [551] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [552] "Tumor-promoting compounds obtained from CROTON OIL (Croton tiglium). Some of these are used in cell biological experiments as activators of protein kinase C. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [553] "Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to the hexahydroxy alcohol, myo-inositol. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid, myo-inositol, and 2 moles of fatty acids. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [554] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [555] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [556] "A group of isomeric compounds that are monomethyl derivatives of pyridines derived from coal tar, horse urine, and bone oil."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [557] "A substance that gives color to tissue. Pigments are responsible for the color of skin, eyes, and hair."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [558] "A drug used to increase salivation in people who have dry mouth caused by opioids or radiation therapy. Pilocarpine belongs to the family of drugs called alkaloids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [559] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [560] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [561] "4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2- benzothiazine-3-carboxamide- 1,1-dioxide; nonsteroidal antiinflammatory drug (NSAID) which functions by inhibiting prostaglandin synthesis; effective against colon cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [562] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [563] "An inactive substance that looks the same as, and is administered in the same way as, a drug in a clinical trial."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [564] "Any extrachromosomal hereditary determinant. Plasmids are self-replicating circular molecules of DNA that are found in a variety of bacterial, archaeal, fungal, algal, and plant species. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [565] "A cationic glycoprotein growth hormone carried in the alpha-granules of platelets that is mitogenic for cells at the site of a wound.  It consists of homologous polypeptides A and B (~30 kD) linked by disulphide bonds.  The B chain is almost identical in sequence to p28sis, the transforming protein of simian sarcoma virus.  It is released when platelets adhere to traumatized tissues and causes endothelial proliferation.  Mesenchymal connective tissue cells, fibroblasts, smooth muscle cells, and glial cells near a traumatized region respond by initiating the process of replication. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                
  [566] "A metal that is an important component of some anticancer drugs, such as cisplatin and carboplatin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [568] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [569] "A class or organic compounds composed of carbon, hydrogen, and nitrogen containing two or more amino groups with some compounds acting as essential growth factors for microorganisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [570] "Polychlorinated Biphenyls (PCBs) are a family of more than 200 chemical compounds (congeners) with 1 to 10 chlorine atoms attached to biphenyl and a general structure of C12H10-xClx. PCBs were commercially produced as complex mixtures of congeners at different degrees of chlorination for a variety of applications. Their use was based on their chemical stability, and desirable physical properties. According to WHO, several congeners are now considered to be \"dioxin-like\" because of their toxicity and certain features of their structure similar to 2,3,7,8-tetrachlorodibenzo-p-dioxin. PCBs are not readily biodegradable, their use declined and was essentially terminated because of environmental concerns. USA stopped producing PCBs in 1977. (NCI)"                                                                                                                                                                                                                  
  [571] "Polycyclic aromatic hydrocarbons (PAH) are a large class of organic compounds containing two or more fused aromatic rings made up of carbon and hydrogen atoms. They have high melting and boiling-points, low vapour pressure, water solubility, and are highly lipophilic. PAH are produced during incomplete combustion or pyrolysis of organic matter, are found in cigarette smoke, motor vehicle exhaust, used motor lubricating oil, broiled meat, coal tar, crude oil, creosote, roofing tar, dyes, plastics, and pesticides. Some members of PAH class were shown to have carcinogenic, genotoxic, and immunotoxic properties, developmental toxicity and affect reproductive health. (NCI)"                                                                                                                                                                                                                                                                                               
  [572] "an addition polymer of ethylene oxide and water."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [573] "An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species.  Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis.  Porfiromycin is preferentially toxic to hypoxic cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [574] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [575] "(po-TASS-ee-um) A metallic element that is important in body functions such as regulation of blood pressure and of water content in cells, transmission of nerve impulses, digestion, muscle contraction, and heartbeat."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [576] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [577] "1-(4-amino-6,7-dimethoxy- 2-quinazolinyl) -4-(2-furoyl) piperazine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [578] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [579] "A synthetic corticosteroid used in the treatment of blood cell cancers (leukemias) and lymph system cancers (lymphomas)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [580] "Belongs to the family of drugs called steroids and is used to treat several types of cancer and other disorders. Prednisone also inhibits the body's immune response."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [581] "A synthetic, 8-aminoquinoline derivative with antimalarial properties.  Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA.  This agent eliminates tissue (exo-erythrocytic) malarial infection, preventing the development of the erythrocytic forms of the parasite which are responsible for relapses in Plasmodium vivax and ovale malaria.  Primaquine is active against late hepatic stages (hypnozoites, schizonts). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [582] "A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called antibiotic therapy adjuncts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [583] "An anticancer drug that belongs to the family of drugs called alkylating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [584] "(pro-klor-PAIR-a-zeen) A drug that prevents or reduces nausea and vomiting.  It belongs to the family of drugs called antiemetics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [585] "Brand-name for prochlorperazine, an antipsychotic and antiemetic agent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [586] "class of drugs which mimic progesterone by promoting gestation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [587] "Pregn-4-ene-3,20-dione. The principal progestational hormone of the body, secreted by the corpus luteum, adrenal cortex, and placenta. Its chief function is to prepare the uterus for the reception and development of the fertilized ovum. It acts as an antiovulatory agent when administered on days 5-25 of the menstrual cycle. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [588] "glycoprotein hormone secreted by the anterior pituitary; in mammals it stimulates the production of milk and assists in maintaining the corpus luteum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [589] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [590] "A specific strain or preparation of Corynebacterium parvum used as an adjuvant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [591] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [592] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [593] "Compounds that interfere with the ability of certain enzymes to break down proteins.  Some protease inhibitors can keep a virus from making copies of itself (e.g., AIDS virus protease inhibitors), and some can prevent cancer cells from spreading."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [594] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [595] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [596] "bicyclic ring structure consisting of fused imidazole and pyrimidine rings, with nitrogen atoms at the 1,3,7, and 9 positions; the basic structure of adenine, guanine, and other biologically important bases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [597] "An amminoglycoside antibiotic isolated from the bacterium Streptomyces alboniger.  Acting as an analog of the 3' terminal end of aminoacyl-tRNA (transfer ribonucleic acid), puromycin incorporates itself into a growing polypeptide chain and causes its premature termination, thereby inhibiting protein synthesis.  This agent has antimicrobial, antitrypanosomal, and antineoplastic properties; its is used as an antibiotic in cell culture. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [598] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [599] "6-membered aromatic ring structure with 2 meta nitrogen heteroatoms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [600] "covalently linked adjacent pyrimidine bases (usually thymidine) on a strand of DNA produced by UV light or other radiation; the mutation blocks both transcription and replication until excised and repaired."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [601] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [602] "A flavonol from azaleas being evaluated for its chemopreventive qualities. (Chemical and Physical Carcinogenesis Branch, DCB homepage)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [603] "D isomer of quinine; sometimes used as an antimalarial in patients who cannot tolerate quinine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [604] "quinine ascorbate is listed by USP as a smoking deterrent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [605] "The basic structure of quinolone is nalidixic acid that has limited therapeutic value.  However, the development of fluorinated quinolones led to new derivative compounds with broad antibacterial activity.  Both DNA gyrase and topoisomerase IV are targets of quinolones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [607] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [608] "Drugs that make tumor cells more sensitive to radiation therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [609] "An unstable element that releases radiation as it breaks down. Radioisotopes can be used in imaging tests or as a treatment for cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [610] "(RAY-don) A radioactive gas that is released by uranium, a substance found in soil and rock. Breathing in too much radon can damage lung cells and lead to lung cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [611] "A topoisomerase II inhibitor with anti-angiogenic activity.  Also used as an chemoprotective agent to prevent cardiotoxicity from anthracycline antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [612] "A chemical substance when added to the solution of another substance participates in a chemical reaction.  A reagent may be a simple compound or a mixture of various compounds and may be named using chemical nomenclature or the name(s) of its discoverer(s).  Reagents are used in research laboratories, medicine or industry in various procedures to diagnose diseases or synthesize other compounds. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [613] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [614] "A group of agents that includes retinol (Vitamin A) and related compounds with potential antineoplastic and/or chemopreventive activities.  A retinoic acid agent binds to and/or activates specific nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs), thereby modulating transcription of genes responsible for cell differentiation and proliferation.  A retinoic acid agent may exhibit immunomodulatory and anti-inflammatory properties and may inhibit ornithine decarboxylase, resulting in a decrease in polyamine synthesis and keratinization.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                             
  [615] "Antibodies in the serum of individuals with rheumatoid arthritis that react with antigenic determinants or immunoglobulins that enhance agglutination of suspended particles coated with pooled human gamma -globulin. Rheumatoid factors also occur in other autoimmune and certain infectious diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [616] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [617] "1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamid e; antiretroviral agent with potential efficacy against AIDS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [618] "7,8-dimethyl-10-ribitylisoalloxazine: a heat-stable factor of the water-soluble vitamin B complex whose isoalloxazine nucleotides are coenzymes of the flavodehydrogenases. Its principal forms in tissues and cells are as FMN and FAD."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [619] "A highly toxic protein phytotoxin lectin and hemagglutin from the seeds of Ricinus communis, the castor oil plant.  It agglutinates cells, is proteolytic, and causes lethal inflammation and hemorrhage if taken internally.  It has N-glycosidase activity that cleaves 28S rRNA, halting protein synthesis; extreme cytotoxicity makes ricin an attractive candidate for artificial fusion with binding proteins to create cell-type-specific toxins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [620] "One of the two glycoprotein disulfide-linked chains of Ricinus Communis Agglutin II that causes protein synthesis inhibition and cell death. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [621] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [622] "A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and sugar units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [623] "Messenger RNA.  A class of RNA molecules that contain protein-coding information in their nucleotide sequence and can be translated into the amino acid sequence of a protein. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm."                                                                                                                                                                                                                                                        
  [624] "Ribosomal RNA.  Class of RNA molecules that do not contain protein-coding sequence information.  These RNAs constitute the majority of the cellular RNA (~ 80%); they associate with multiple proteins into a macromolecular complex termed ribosomes, in which mRNA-directed protein synthesis occurs.  The three eukaryotic rRNAs are named 28S, 18S, and 5S rRNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [625] "Small nuclear RNA.  A class of abundant small nuclear RNAs involved in RNA processing (splicing, 3' end maturation).  These snRNAs associate with specific proteins to form the small nuclear ribonucleoprotein particles (snRNP) directly involved in RNA processing.  Seven known snRNAs have been termed U1 through U7 snRNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [626] "Small RNA molecules, 73-93 nucleotides, occurring in cells in 20 or more varieties and functioning in translation. Each variety carries a specific amino acid to a site specified by an RNA codon, binding to amino acid, ribosome, and to the codon, via an anticodon region. All have numerous modified bases and extensive secondary structure. (Dorland, 28th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [627] "An antibiotic drug used to treat infection. It belongs to the family of drugs called cephalosporin antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [628] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [629] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [630] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [631] "A solution of salt and water."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [632] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [633] "A substance found in soybeans and many other plants. Saponins may help lower cholesterol and may have anticancer effects."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [634] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [635] "A nonmetallic chemical element found in trace amounts in human body. It is in the form of selenocompounds, mostly selenoproteins such as glutathione peroxidase and thioredoxin reductase (enzymes responsible for detoxification).  Alone or in combination with Vitamin E, selenocompounds act as antioxidants.  These agents scavenge free radicals, harmful particles that damage lipids, proteins and genetic material, therefore contributing to premature aging and the development of numerous diseases, including cancer.  Selenium also prevents blood clots by inhibiting platelet aggregation, strengthens the immune system, and inhibits chromosome damage, mutations and cancer promotion.  Selenocompounds block the induction of protein kinase C function, thereby eliciting a cancer-prevention action. (NCI04)"                                                                                                                                                                 
  [636] "A substance containing selenium, a trace element, in place of the sulfur in methionine, an amino acid, used as a nutritional supplement for selenium.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [637] "An anticancer drug that belongs to the family of drugs called alkylating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [638] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [639] "Smoke from burning tobacco; it is inhaled as smoke from cigarettes, cigars, or pipes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [640] "A mineral needed by the body to keep body fluids in balance.  Sodium is found in table salt and in many processed foods.  Too much sodium can cause the body to retain water."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [641] "A synthetic therapeutic diphosphonate analogue of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, etidronate disodium differs from endogenous pyrophosphate in its resistance to enzymatic hydrolysis.  This agent adsorbs to hydroxyapatite cells and reduces the number of osteoclasts, thereby inhibiting abnormal bone resorption.  Etidronate may also directly stimulate bone formation by osteoblasts. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [642] "An inorganic salt of fluoride used topically or in municipal water fluoridation systems to prevent dental caries.  Fluoride appears to bind to calcium ions in the hydroxyapatite of surface tooth enamel, preventing corrosion of tooth enamel by acids. This agent may also inhibit acid production by commensal oral bacteria. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [643] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [644] "A drug that belongs to the family of drugs called nonsteroidal anti-inflammatory drugs.  Sodium salicylate may be tolerated by people who are sensitive to aspirin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [645] "Insulin-Like Growth Factor binds specifically to high-affinity membrane-associated receptor that is a tyrosine kinase and has acute insulin-like metabolic effects and long-term actions, mediating many of the anabolic effects of circulating growth hormone. It stimulates sulfate incorporation into collagen, RNA, DNA, and protein synthesis, bone formation, glucose uptake in muscle, and neuronal survival and myelin synthesis, it also reverses negative nitrogen balance during underfeeding and inhibits protein degradation in muscle. For these reasons it has been proposed as a therapy for osteoporosis, various catabolic states, diabetes, obesity, neuromuscular disorders, growth hormone and insulin resistance. (NCI)"                                                                                                                                                                                                                                                      
  [646] "A class of synthetic agents which inhibit the secretion or release of a particular growth hormone.  These agents may counteract the action of growth hormone release factors, which are secreted by the hypothalamus, gut, pancreas and gonads and stimulate pituitary growth hormone synthesis and secretion. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [647] "A synthetically-derived form of endogenous growth hormone (GH), a polypeptide produced by the pituitary gland.  The synthetic therapeutic form is usually derived from recombinant sources. GH exhibits growth-promoting effects and metabolic effects on carbohydrate, fat, protein and bone metabolism.  GH stimulates protein synthesis and the uptake of amino acids into the cells, and induces lipolysis in adipose tissues.  GH secretion increases with sexual maturation and then it declines steadily. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [648] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [649] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [650] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [651] "A dye or other coloring material that is used in microscopy to make structures visible."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [652] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [653] "(STAIR-oyd) A type of drug used to relieve swelling and inflammation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [654] "An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus.  Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis.  This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [655] "2-deoxy-2-(3-methyl-3-nitrosoureido) -D-glucopyranose; USP antineoplastic antibiotic; at high doses it destroys pancreatic beta cells and can be used to create experimental animal models of diabetes mellitus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [656] "A metal often used in a radioactive form for imaging tests or as a treatment for cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [657] "An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of pain, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [658] "A drug used to treat ulcers. It adheres to proteins at the ulcer site and forms a protective coating over the ulcer. Sucralfate is also used to treat mucositis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [659] "any compound of the type R-SO2-R."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [660] "A nonsteroidal anti-inflammatory drug (NSAID) that is being studied as a treatment for cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [661] "A substance that helps protect the skin from the sun's harmful rays. Sunscreens reflect, absorb, and scatter both ultraviolet A and B radiation to provide protection against both types of radiation. Using lotions, creams, or gels that contain sunscreens can help protect the skin from premature aging and damage that may lead to skin cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [662] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [663] "A drug used to treat bacterial and parasitic infections. It is also being studied in the treatment of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [664] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [665] "An anticancer drug that belongs to the family of drugs called antiestrogens. Tamoxifen blocks the effects of the hormone estrogen in the body. It is used to prevent or delay the return of breast cancer or to control its spread."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [666] "A radiolabeled substance that is used to help identify sites of tumor development."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [667] "An anticancer drug that is a podophyllotoxin derivative and belongs to the family of drugs called mitotic inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [668] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [669] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [670] "The class of compound known as terpenes comprise of essential oils, flavours and fragrances. The extraction and synthesis of compounds such as these is the basis for the perfumery industry. They find a variety of uses in the food and pharmaceutical industry as flavour and odour improvers"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [671] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [672] "An androgenic anabolic steroid generally administered as an ester derivative and indicated for the use as a testosterone replacement in hypogonadal males, delayed puberty, and metastatic mammary cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [673] "A short acting oil-based injectable formulation of testosterone. Clinical Use: Androgen Replacement Therapy and Postpartum Breast Engorgement. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [674] "2,3,7,8-Tetrachlorodibenzo-p-dioxin which is often referred to simply as dioxin and is the reference for a number of compounds which are similar structurally and have dioxin-like toxicity. A substance extremely toxic to mammals, with a wide variation in sensitivity among species. Longer-term exposure of test mammals to lesser amounts can affect reproduction, cause birth defects, damage the liver and suppress the immune system. Several studies suggest that exposure to TCDD increases the risk of several types of cancer in people. Animal studies have also shown an increased risk of cancer from exposure to TCDD. The WHO and the USA DHHS have determined that TCDD is a human carcinogen. (NCI)"                                                                                                                                                                                                                                                                            
  [675] "4-(dimethylamino)-1,4,4A,5,5A,6,11,12A-octahydro-3,6,10,12,12A-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide. A broad-spectrum antibiotic used for its bactericidal action in human and veterinary medicine, originally produced by Streptomyces viridifaciens. It is an inhibitor of aminoacyl-tRNA binding during protein synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [676] "A drug that is being studied as a treatment for hematologic cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [677] "A psychoactive substance found in Cannabis sativa. Dronabinol acts directly on the appetite and vomiting control centers in the brain to stimulate appetite and prevent emesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [678] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [679] "Plant alkaloid possessing antiproliferative and antitumor activities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [680] "A drug that belongs to the family of drugs called angiogenesis inhibitors. It prevents the growth of new blood vessels into a solid tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [681] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [682] "1,3-dimethylxanthine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [683] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [684] "A heat-labile and water-soluble vitamin contained in milk, yeast, synthesized; in the germ and husk of grains, also artificially synthesized; essential for growth; a deficiency of thiamin is associated with beriberi and Wernicke-Korsakoff's syndrome. SYN aneurine, antiberiberi factor, antiberiberi vitamin, antineuritic factor, antineuritic vitamin, thiamine, vitamin B1."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [685] "An anticancer drug that belongs to the family of drugs called alkylating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [686] "An anticancer drug that belongs to the family of drugs called antimetabolites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [687] "A sulfhydryl analog of inosine that inhibits nucleotide transport and exhibits immunosuppressive activity. Clinical Use: Leukemia.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [688] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [689] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [690] "A chemical compound found in DNA. Also used as treatment for mucositis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [691] "2,4-diketo-5-methylpyrimidine; one of the 5 major bases (with adenine, guanine, cytosine, and uracil) found in nucleic acids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [692] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [693] "A recombinant form of an immune hormone secreted by the thymus gland that stimulates the immune system by potentiating the differentiation and maturation of T-lymphocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [694] "(THIGH-roe-GLOB-yu-lin) The form that thyroid hormone takes when stored in the cells of the thyroid. If the thyroid has been removed, thyroglobulin should not show up on a blood test. Doctors measure thyroglobulin level in blood to detect thyroid cancer cells that remain in the body after treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [695] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [696] "Hormones secreted by the thyroid gland. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [697] "A peptide hormone secreted by the anterior pituitary. It promotes the growth of the thyroid gland and stimulates the synthesis of thyroid hormones and the release of thyroxine by the thyroid gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [698] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [699] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [700] "A drug used to treat protozoal infections, such as amebiasis, giardiasis, and trichomoniasis. It belongs to a family of drugs called antiprotozoal agents. Tinidazole is also being evaluated in the treatment of Helicobacter pylori infections in people with low-grade gastric lymphoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [701] "The leaves of the tobacco plant, Nicotiana tabacum, dried and prepared for smoking or ingestion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [702] "RAEB: Chewing tobacco, snuff. Also code SIC 2. Use site 0700 (head and neck) unless a more specific site is indicated in the text. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [703] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [704] "A chemical, physical, or biological agent that causes disease or some alteration of the normal structure and function of an organism. Usually refers to poisonous substance produced during the metabolism and growth of certain microorganisms and some higher plant and animal species, or any poisonous isomer, homolog, or derivative of such a substance. It causes either permanent or reversible injury to the health of a living thing on contact or absorption, typically by interacting with biological macromolecules such as enzymes and receptors. Onset of effects may be immediate or delayed, and impairments may be slight or severe. (NCI)"                                                                                                                                                                                                                                                                                                                                       
  [705] "A glycosidic antineoplastic antibiotic isolated from the bacterium Streptomyces griseus.  Chromomycin A3 reversibly binds to guanine-cytosine (G-C) base pairs in the minor groove of DNA, thereby inhibiting RNA synthesis.  This agent is used as a fluorescent chromosome dye. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [706] "A chemical found in very small amounts in a given substance. Organisms need certain trace elements to survive."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [707] "A recombinant form of Transforming Growth Factor-Alpha, a polypeptide growth factor involved with the growth and differentiation of epidermal and epithelial cells, playing a role in phenotypic transformation.  It is structurally and functionally similar to Epidermal Growth Factor (EGF) and binds to the same receptor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [708] "A synthetic analog of endogenous transforming growth factor beta (TGF-beta), which was expressed in tissues including platelets, placenta, and in both normal and transformed cells.  It acts synergistically with TGF-alpha in inducing transformation and can act as a negative autocrine growth factor.  TGF-beta also has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [709] "A recombinant therapeutic agent which is chemically identical to or similar to endogenous transforming growth factor (TGF).  Representing peptides of two distinct classes, designated TGF-alpha and TGF-beta, TGFs are produced by various non-transformed cells during the development of mammalian embryos and are found in urine and plasma; TGFs are also produced by some human carcinomas and cell lines transformed by viral and cellular oncogenes.  TGFs affect bone formation and remodeling by inhibition of the synthesis of collagen and release of calcium. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                 
  [710] "A drug that belongs to the family of drugs called retinoids. It is used in the treatment of acne and is being studied in cancer prevention."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [711] "(try-am-SIN-oh-lone) A substance that is being studied for the prevention of nonmelanoma skin cancer.  It is an anti-inflammatory drug that is applied to the skin to relieve irritation, rashes, and infections.  It belongs to the family of drugs called topical corticosteroids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [712] "An organic compound having hydrogen and at least two directly attached nitrogen atoms, which are attached by double or triple bonds. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [713] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [714] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [715] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [716] "Fats composed of three fatty acid chains linked to a glycerol molecule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [717] "A thyroid hormone. Also called liothyronine sodium or T-3."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [718] "A synthetic derivative of trimethoxybenzyl-pyrimidine with antibacterial and antiprotozoal properties.  As a pyrimidine inhibitor of bacterial dihydrofolate reductase, trimethoprim binds tightly to the bacterial enzyme, blocking the production of tetrahydrofolic acid from dihydrofolic acid.  The antibacterial activity of this agent is potentiated by sulfonamides. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [719] "A combination of two anti-infection drugs, sulfamethoxazole and trimethoprim. It is used to fight bacterial and protozoal infections."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [720] "An acid azo dye commonly used as a stain to distinguish viable from non-viable cells. It turns dead cells blue and viable cells unstained. It is a known animal carcinogen and an experimental teratogen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [721] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [722] "1. antigens that may be frequently associated with tumors or may be specifically found on tumor cells of the same origin (tumor specific); 2. tumor antigens may also be associated with replication and transformation by certain DNA tumor viruses, including adenoviruses and papovaviruses. Neoantigens. Any immunologically detectable marker whose presence or amount indicates the presence of a tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [723] "A serum glycoprotein polypeptide hormone less than 70 kD produced by endotoxin-activated macrophages and other mammalian mononuclear leukocytes that has necrotizing activity against tumor cell lines and increases the ability to reject tumor transplants.  It mimics the action of endotoxin but differs from it.  A type of biological response modifier able to modulate adipocyte metabolism, lyse tumor cells, and induce hemorrhagic necrosis of certain transplantable tumors. Use for basic or therapeutic studies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [724] "An agent that acts at stage 2 of carcinogenesis, following the initiation of increased cell proliferation.  It is a necessary step in overt tumor formation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [725] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [726] "Coenzyme Q10 is a lipid-soluble compound primarily synthesized by the body and also consumed in the diet. It is required for mitochondrial ATP synthesis and electron transport between the enzyme complexes of the respiratory chain, and functions as an antioxidant in cell membranes and lipoproteins. Coenzyme Q10 supplementation has resulted in clinical and metabolic improvement in some patients with hereditary mitochondrial disorders. Although Coenzyme Q10 supplementation may be a useful adjunct to conventional medical therapy for congestive heart failure, additional research is needed. Roles for Coenzyme Q10 supplementation in other cardiovascular diseases, cancer, neurodegenerative diseases, and diabetes require further research. (NCI)"                                                                                                                                                                                                                          
  [727] "2,4-diketopyrimidine; one of the 5 major bases (with adenine, guanine, cytosine, and thymine) which are a component of nucleic acids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [728] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [729] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [730] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [731] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [732] "A nucleoside containing ribose and uracil.  One of the pyrimidine precursors of ribonucleic acids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [733] "A substance or group of substances meant to cause the immune system to respond to a tumor or to microorganisms, such as bacteria or viruses. A vaccine can help the body recognize and destroy cancer cells or microorganisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [734] "A cyclic depsipeptide isolated from the bacterium Streptomyces fulvissimus.  As a potassium-specific ionophore, mould element causes loss of mitochondrial membrane potential, thereby initiating cellular apoptosis.  This agent is used in comparative studies of other ionophores. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [735] "An antibiotic drug used to fight resistant bacterial infections."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [736] "A nonapeptide hormone released by the posterior lobe of the pituitary whose primary function is regulating extracellular fluid volume.  It can also act as a vasoconstrictor, increasing blood pressure and systemic vascular resistance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [737] "Small, radioactive pellets that are placed in or near tumors.  Cancer cells are killed by the energy given off as the radioactive material decays (breaks down)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [738] "A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility.  This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [739] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [740] "A vinca alkaloid which reversibly inhibits mitosis by binding to microtubule protein, tubulin, ultimately inhibiting formation of mitotic spindles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [741] "The sulfate salt of vinblastine, a natural alkaloid isolated from the plant Catharanthus roseus (Madagascar periwinkle) with antineoplastic properties.  Vinblastine disrupts microtubule formation and function during mitosis and interferes with glutamic acid metabolism. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [742] "Anticancer drugs that inhibit cancer cell growth by stopping cell division. They are also called antimitotic or antimicrotubule agents, or mitotic inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [743] "A vinca alkaloid which reversibly inhibits mitosis by binding to microtubule protein, tubulin, ultimately inhibiting formation of mitotic spindle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [744] "A vinca alkaloid, which is a synthetic derivative of vinblastine. Vindesine binds to tubulin, inhibiting its polymerization into microtubules.  Inhibiting polymerization disrupts spindle formation and arrests cell division in metaphase, leading to apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [745] "The sulfate salt form of Vindesine. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [746] "(VINE-uhl KLOR-ide) A substance used to make plastics. Exposure to vinyl chloride may increase the risk of developing liver, brain, and lung cancers; lymphoma; and leukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [747] "A class of streptogramin-related depsipeptides isolated from the bacterium Streptomyces virginiae and other Streptomyces bacterial species.  The virginiamycins consist of two major components, virginiamycin M1 and virginiamycin S1.  These agents bind to and inhibit ribosome assembly, thereby preventing protein synthesis.  Active against Gram-positive bacteria, these antibiotics are primarily used in veterinary practice. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [748] "A substance used in cancer prevention.  It belongs to the family of drugs called retinoids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [749] "An essential nutrient and natural water-soluble vitamin of the B-complex family that must combine with an intrinsic factor for absorption by the intestine, Vitamin B12 (cyanocobalamin) is necessary for hematopoiesis, neural metabolism, DNA and RNA production, and carbohydrate, fat, and protein metabolism. B12 improves iron functions in the metabolic cycle and assists folic acid in choline synthesis. B12 metabolism is interconnected with that of folic acid. Vitamin B12 deficiency causes pernicious anemia, megaloblastic anemia, and neurologic lesions. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                
  [750] "A group of water-soluble food substances of several or all of the B-vitamins, including thiamine, riboflavin, niacin (nicotinic acid), niacinamide (nicotinamide), the vitamin B6 group (including pyridoxine, pyridoxal, pyridoxamine), biotin, pantothenic acid, folic acid, possibly para-aminobenzoic."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [751] "A family of lipo-soluble steroids important in absorption, metabolism, and function of calcium and phosphorus for bone and tooth enamel, Vitamin D displays ergocalciferol and cholecalciferol biological properties. Found naturally in animal tissues, cholecalciferol (vitamin D3) is formed in the skin when ultraviolet light activates cholesterol conversion into vitamin D3. Ultraviolet irradiation of Ergosterol (plant vitamin D) forms Ergocalciferol (vitamin D2). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [752] "A substance used in cancer prevention.  It belongs to the family of drugs called tocopherols."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [753] "A substance that promotes the clotting of blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [754] "A group of organic food substances found in animals and plants in small quantities. They must be supplied in diet or dietary supplement and are essential for normal metabolism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [755] "A drug that prevents blood from clotting. It belongs to the family of drugs called anticoagulants (blood thinners)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [756] "A semi-synthetic glucosaminoglycan analog of heparin with anticoagulant, chondroprotective, anti-inflammatory, antiangiogenic and antiviral properties.  Pentosan polysulfate binds to and inhibits the actions of overactive leukocytes; decreases the production of tumor necrosis factor (TNF alpha) and increases interleukin 6 synthesis in order to provide an anti-inflammatory effect; inhibits angiogenesis and tumorigenesis by blocking the basic fibroblast growth factor (bFGF) binding to its cell surface receptor; and binds to and inhibits human immunodeficiency virus 1 (HIV-1) Tat protein, a pleiotropic heparin-binding growth factor involved in AIDS pathogenesis. (NCI04)"                                                                                                                                                                                                                                                                                                
  [757] "A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. (Medical Dictionary Online)"                                                                                                                                                                                                                                                                                                 
  [758] "A bluish-white, lustrous metallic element; atomic number 30, symbol Zn."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [759] "A compound that may enhance immune function, especially when administered by inhalation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [760] "A synthetic triepoxide alkylating agent with cytostatic and immunosuppressant properties.  Anaxirone alkylates DNA via actual or derived epoxide groups, resulting in inhibition of DNA synthesis. This agent exhibits a broad spectrum of antineoplastic activity against experimental tumours, including those resistant to other alkylating agents. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [761] "DBA; 1,2,5,6-Dibenzanthracene; 1,2:5,6-benzanthracene; 1,2:5,6-dibenz[a]anthracene.  A polynuclear aromatic hydrocarbon, dibenz(a,h)anthracene occurs in fossil fuels and may also be released to the environment as a product of incomplete combustion. If released to air, it is expected to exist solely in the particulate phase in the ambient atmosphere. It is a mutagen and is carcinogenic in animals; classified as a probable human carcinogen. Mod from the HSDB database"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [762] "Belongs to a group of antihormone drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [763] "An aziridinyl-substituted cyclophosphazene and a putrescence derivative that may cause DNA cross-linkage. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [764] "1-(2-chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea, an antineoplastic agent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [765] "An antimetabolite (pyrimidine analogue) antineoplastic derivative of 5-fluorouracil. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [766] "A membrane-targeting anticancer ether lipid drug.  Has shown antiangiogenesis activity in vitro."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [767] "A taxane derivative (paclitaxel analogue) which causes stabilization of microtubule bundles arresting the cell cycle at mitosis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [768] "A polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [769] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [770] "A synthetic progestational hormone which in general acts as negative feedback at the level of the hypothalamus and pituitary. It is involved in the regulation of gene transcription. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [771] "An anticancer drug that belongs to the family of drugs called antimetabolites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [772] "A nitrogen mustard vesicant that has application in chemical warfare, and has been used as a cytostatic alkylating agent in anti cancer therapy. Current Use: Leukaemia and Lymphoma. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [773] "An anticancer drug that belongs to the family of drugs called alkylating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [774] "The radioactive form of glucose used in positron emission tomography (PET), a diagnostic imaging procedure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [775] "2ME2. A drug derived from estrogen that belongs to the family of drugs called angiogenesis inhibitors.  It prevents the formation of new blood vessels that tumors need in order to grow."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [776] "A chlorinated derivative of methotrexate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [777] "The triphosphate salt of Cordycepin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [778] "A purine nucleoside analogue having antitumor/antiviral activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [779] "A phenolic analogue of tamoxifen. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [780] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [781] "A substance that is being studied as a treatment for cancer, and for primary systemic amyloidosis (a disease in which proteins are deposited in specific organs). It belongs to the family of drugs called anthracycline analogues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [782] "A synthetic derivative of the anthracycline antineoplastic antibiotic doxorubicin.  Deoxydoxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent exhibits less cardiotoxicity than the parent antibiotic doxorubicin, but may cause severe myelosuppression. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [783] "A bisphosphonate with increased antiresorption activity (100x-1000x that of etidronate)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [784] "An agent that inhibits estrogen synthesis by aromatase inhibition."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [785] "A tamoxifen metabolite with both estrogenic and anti-estrogenic effects.  4-hydroxytamoxifen has a higher affinity for the estrogen receptor than tamoxifen, and functions as an antagonist in breast cancer cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [786] "A natural toxic furan isolated from a fungus-infected sweet potato (Ipomoea batatas) with potential antineoplastic activity.  Ipomeanol is activated by mixed function oxidases in vivo to its epoxide form, an alkylating agent that covalently binds cell macromolecules. This agent causes cell death by a p53-independent mechanism. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [787] "A synthetic derivative of estradiol. 4-nitroestrone 3-methyl ether inhibits estrogen sulfotransferase (EST), a progesterone-induced secretory endometrial enzyme which affects estrogen receptor levels.  This agent has been shown to be an effective growth inhibitor of some chemically induced animal mammary tumors. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [788] "An antimetabolite that is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase, interfering with DNA biosynthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [789] "A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called antifolates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [790] "A synthetic nucleoside analogue of deoxycytidine. Dihydro-5-azacytidine inhibits DNA methyltransferase, thereby interfering with abnormal DNA methylation patterns that are associated with genetic instability in some tumor cells. Inhibition of this enzyme may restore expression of tumor-suppressor genes and result in antitumor activity. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [791] "A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [792] "A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity.  Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis.  This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [793] "An orally administered inhibitor of alpha glucosidase that decreases the digestion and absorption of carbohydrates in the small intestine and leads to decreased blood glucose levels after a carbohydrate load. Current Use: Type II Diabetes Mellitus (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [794] "A B-glucuronidase inhibitor which may act as a chemopreventive agent in colon carcinogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [795] "A drug used in cancer prevention that belongs to the family of drugs called retinoids. It is also used in the treatment of psoriasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [796] "A modified amino acid and structural analog of glutamine.  Acivicin inhibits glutamine amidotransferases in the purine and pyrimidine biosynthetic pathways, thereby inhibiting tumor growth in cell lines dependent on glutamine metabolism. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [797] "A class of antineoplastic oligosaccharide anthracycline antibiotics isolated from various strains of the bacterium Streptomyces galilaeus.  These agents display potent antitumor properties due to their ability to intercalate into DNA and inhibit topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [798] "A synthetic imidazoquinoline with antineoplastic activity. Acodazole intercalates into DNA, resulting in disruption of DNA replication.  Use of this agent has been associated with significant cardiotoxicity. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [799] "Dimeric growth factors of the TGF family with effects on a range of cell types in addition to promoting FSH release in gonadal sites. Composed of two of the subunits of inhibin, the isoforms A and B."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [800] "Bacterial extract, a non-specific immune-modulator in development as maintenance adjunct immunotherapy following surgery in treating patients with breast cancer, colon cancer, or melanoma. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [801] "Adult T-cell Leukemia derived factor: Human thioredoxin. A cytokine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [802] "A monobenzyl ether of hydroquinone that destroys melanocytes and causes permanent depigmentation of the skin. The exact mechanism of action is unknown. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [803] "A mixture of neutral lipids (70%), phosphatidylcholine (20%) and phosphatidylethanolamine (10%), AL721 removes cholesterol from outer cell membranes, increases membrane fluidity, and impairs virus attachment to cell receptors. AL721 is potentially useful (and in study) for diseases where membrane fluidity plays a role (cancers, cystic fibrosis). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [804] "An amino acid analog derived from Streptomyces alanosinicus, a purine antagonist, and an adenylosuccinate synthetase inhibitor with antineoplastic properties, L-Alanosine deprives MTAP-deficient (salvage pathway) cancer cells of de novo synthesized adenosine and is probably responsible for diminished DNA synthesis. Although in study for cancer chemotherapy, L-Alanosine use might be narrow due to toxicity. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [805] "A substituted benzamide that acts as a dopamine receptor antagonist with antiemetic properties. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [806] "An antimitotic agent that binds to tubulin and inhibits tubulin polymerization and arrests proliferation of tumor cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [807] "An essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils and has been reported to inhibit the synthesis of prostaglandin resulting in reduced inflammation and prevention of certain chronic diseases. Current Use: Prevention of heart diseases, arthritis, breast and colon cancers. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [808] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [809] "An imide derivative of naphthalic acid."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [810] "A recombinant form of amphiregulin, a member of the heparin-binding epidermal growth factor (EGF) family. Endogenous amphiregulin is an autocrine growth factor, and binds to the EGF receptor. Overexpressed in several cancer cell types, endogenous amphiregulin may contribute to tumor cell proliferation and metastasis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [811] "A synthetic derivative of inosinic acid with antiretroviral and immunomodulatory properties.  Atvogen acts through a number of pathways to stimulate intracellular antiviral activity of the immune system: it stimulates interferon production; activates the oligoadenylate synthetase RNase L pathway; stimulates natural killer cell activity; and acts as a nonmitogenic stimulator of the immune system. This agent also inhibits replication of human immunodeficiency virus (HIV) in vitro. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [812] "A 14kD non-glycosylated human derived angiogenesis factor, which has the ability to induce neovascularisation with a unique ribonucleolytic activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [813] "A group of anticancer drugs that belongs to the family of drugs called antineoplastic antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [814] "A piperidinedione antineoplaston with potential antineoplastic activity.  Antineoplaston A10 was originally isolated from human urine but is now synthetically derived.  This agent intercalates into DNA, resulting in cell cycle arrest in G1 phase, reduction of mitosis, and decreased protein synthesis.  Antineoplaston A10 may also inhibit ras-oncogene expression and activate tumor suppressor gene p53, leading to cell differentiation and apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [815] "A small-molecule arsenic compound with antineoplastic activity.  Arsenic trioxide induces apoptosis in acute promyelocytic leukemia (APL) cells; downregulates the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein; promotes cell differentiation; suppresses cell proliferation; and is pro-angiogenic.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [816] "A synthetic ammonium trichloro-tellurate derivative with potential immunomodulatory and antiparasitic properties.  Ossirene may increase cell proliferation, cytokine secretion, and the production of nitric oxide, and may activate neutrophils and macrophages. This agent has been studied as a possible treatment for babesiosis, a tick-transmitted parasitic disease. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [817] "An anti cancer agent that has been studied in the treatment of soft tissue sarcomas in children. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [818] "A drug used in the treatment of psoriasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [819] "A monofunctional alkylating agent with potential antineoplastic activity.  Reacting with DNA mainly at guanine and adenine residues, ethylenimine alkylates DNA, thereby producing DNA interstrand crosslinks and DNA breaks, and interfering with DNA replication and cell division. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [820] "An antithrombotic and antimetastatic agent having a pyrazolone functionality that inhibits peroxidation of phosphatidylcholine liposomes, heart homogenate, and low-density lipoproteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [821] "A cyclic hexadepsipeptide antibiotic and mycotoxin isolated from the fungus Beauveria bassiana and various Fusarium fungal species.  As a potassium-specific ionophore, beauvericin A increases intracellular calcium concentrations and triggers DNA fragmentation and apoptosis through a calcium dependent caspase 3-sensitive pathway.  This agent has been studied as a potential antineoplastic agent. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [822] "Drugs from this chemical class are used for their central nervous system depressant properties including sedation, facilitation of sleep, seizure control, general anesthesia, anxiolytic, amnestic, and for detoxification from similar (cross tolerant) drugs"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [823] "A nitroimidazole derivative having an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [824] "Approved for photodynamic therapy of age-related macular degeneration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [825] "An aminopeptidase B and leucine aminopeptidase inhibitor.  A biological response modifier that exhibits direct antileukemic effects against human leukemic cell lines through the induction of apoptosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [826] "A naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities.  As an anti-oxidant, beta carotene inhibits free-radical damage to DNA.  This agent also induces cell differentiation and apoptosis of some tumor cell types, particularly in early stages of tumorigenesis, and enhances immune system activity by stimulating the release of natural killer cells, lymphocytes, and monocytes.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [827] "A chemopreventive compound that inhibits beta-glucuronidase and prevents hydrolysis of their glucuronides. Examples are calcium D-glucarate and saccharolactone. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [828] "An immunostimulant glycoprotein extracted from Klebsiella pneumoniae."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [829] "A novel intercalating cytotoxic agent under investigation as an anticancer agent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [830] "A bismuth salt of salicylic acid.  Little absorbed from the gastrointestinal tract, bismuth subsalicylate exerts a local effect on the gastric mucosa, coating it and protecting it from the corrosive effects of acid and pepsin.  This agent also has local antimicrobial properties. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [831] "A serotonin antagonist having antiemetic properties. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [832] "An anticancer drug that belongs to the family of drugs called antimetabolites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [833] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [834] "An oral immunostimulant that causes the body to produce interferon and other substances."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [835] "A triterpene quassinoid antineoplastic antibiotic isolated from the plant Brucea antidysenterica.  Bruceantin inhibits the peptidyl transferase elongation reaction, resulting in decreased protein and DNA synthesis.  Bruceantin also has antiamoebic and antimalarial activity. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [836] "A drug used for its antitumor activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [837] "(try-am-SIN-oh-lone) A substance that is being studied for the prevention of nonmelanoma skin cancer.  It is an anti-inflammatory drug that is applied to the skin to relieve irritation, rashes, and infections.  It belongs to the family of drugs called topical corticosteroids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [838] "A flavonoid obtained from the seed of Cyclopia subternata. It is a specific protein tyrosine kinase inhibitor that induces apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [839] "A drug that may help prevent resistance to some anticancer drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [840] "A synthetic oxytocin, for injection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [841] "A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting folate metabolism and DNA synthesis and cell division. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [842] "A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces chrysomallus.  Cactinomycin binds to DNA by intercalating between guanine and cytosine, forming stable antibiotic-DNA complexes that inhibit RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [843] "Commercial citrate of caffeine, though not a definite salt.  It is the alkaloid caffeine, with a portion of adherent citric acid, as indicated by its pharmacopoeial. name (citrated caffeine). Its general action and uses are the same as those given under caffeine. Citrated caffeine is used chiefly as a remedy for the idiopathic headache (migraine). This salt is very soluble in water, and is assimilated much more readily than pure caffeine when taken into the stomach."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [844] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [845] "An oligosaccharide enediyne antineoplastic antibiotic isolated from the bacterium Micromonospora echinospora ssp. Calichensis.  Calicheamicin Gamma 1I binds to the minor groove of DNA, resulting in site-specific double-strand breaks and apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [846] "Vegetable oil developed from rapeseed plant. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [847] "An agent derived from acetohydroxamic acid with potential antineoplastic activity.  Caracemide inhibits ribonuclease reductase, resulting in decreased DNA synthesis and tumor growth; it also inhibits acetylcholinesterase.  In vivo, caracemide contributes to the formation of the neurotoxin methyl isocyanate; this effect, along with the agent's acetylcholinesterase activity, may be responsible for the severe central nervous system toxicity observed in clinical trials. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [848] "An inhalant of oxygen and carbon dioxide that increases the sensitivity of tumor cells to the effects of radiation therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [849] "An anti-HIV agent that exerts its effects by inhibiting reverse transcriptase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [850] "An ethylenimine antineoplastic antibiotic isolated from the bacterium Streptomyces sahachiroi.  Carzinophilin forms interstrand DNA cross-links, thereby inhibiting DNA synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [851] "A drug used to treat infection.  It belongs to the family of drugs called cephalosporin antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [852] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [853] "A water-soluble nitrosourea that cross-links with DNA, causing inhibition of DNA synthesis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [854] "A non-steroidal aromatase inhibitor effective in the treatment of estrogen-dependent disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [855] "The flower-heads of either the plant Anthemis nobilis or the plant Matricaria chamomilla.  Chamomile has a warm aromatic odour and a very bitter taste and contains volatile oils which are a mixture of butyl and amyl angelates and valerates.  Due to its coumarin constituents, large doses may interfere with coagulation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [856] "A quassinoid phytochemical isolated from Ailanthus integrifolia sp. calycina and other plant species with potential antineoplastic activity.  Chaparrinone inhibits protein synthesis, has antimalarial properties, and is cytotoxic to some tumor cells.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [857] "An alkylating antineoplastic agent no longer used in the United States, because it induces chromosomal aberration and causes cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [858] "A rhodamine-based dye used as a photosensitizing agent in cytotoxic photodynamic therapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [859] "A glucose-linked chloroethylnitrosourea with potential antineoplastic activity.  Chlorozotocin alkylates DNA and proteins, induces the formation of interstrand DNA and DNA-protein crosslinks, and causes DNA strand breakage, thereby damaging DNA and resulting in cell death.  This agent has been shown to exhibit antitumor and immunomodulatory effects in cell lines and animal models.  Chlorozotocin is a mutagen and is less myelotoxic than other nitrosoureas. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [860] "A synthetic derivative of acridine carboxamide with antineoplastic properties.  CI-921, a lipophilic and water-soluble analog of amsacrine, inhibits the enzyme topoisomerase ll, thereby blocking DNA replication and RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [861] "A quinolinone derivative, 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone, cellular phosphodiesterase inhibitor, more specific for phosphodiesterase III. Cilostazol is approved by FDA for the reduction of symptoms of intermittent claudication. The mechanism of the action is not fully understood. The agent and its metabolites suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation. These actions may contribute to its effect, but other drugs with those properties are not known to be useful in intermittent claudication. Cilostazol is contraindicated for patients with congestive heart failure. Concomitant use with clopidogrel must be studied. (NCI)"                                                                                                                                                                                         
  [862] "An immunomodulator, 3,6-bis(2-piperidinoethoxy) acridine trihydrochloride, used in a phase I study for possible immunostimulatory effects in colorectal cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [863] "A third-generation, water-soluble platinum compound. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [864] "An antibiotic drug used to treat infection. It belongs to the family of drugs called macrolides."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [865] "A mixed-backbone oligonucleotide inhibiting the expression of TRPM-2 (Clusterin), causing sensitization of tumor cells to standard anticancer therapy.  OGX-011 (TRPM-2 Antisense Oligonucleotide or Clusterin Antisense Oligonucleotide) has been in clinical trials for prostate cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [866] "A synthetic polymer (copolymer of 1,3-bis(methylaminocarboxyl)-2-methylenepropanecarbamate and N-vinyl pyrrolidone) of low molecular weight which acts as a nonspecific immune modulator and has been shown to have significant antitumor activity in vitro and in vivo in preclinical and some early clinical studies. The mechanism of action is unknown. Immunologic evaluation revealed some improvement in helper and suppressor T cell ratio, in vitro cytotoxicity tests, and lymphocyte blastogenic response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [867] "A purine nucleoside antimetabolite analogue and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity. Cordycepin incorporates into RNA, and, inhibits RNA chain elongation and synthesis due to the absence of a hydroxyl moiety at the 3' position.  Because it is converted to an inactive metabolite by adenosine deaminase, this agent must be administered with an adenosine deaminase inhibitor in order to be effective.  Cordycepin has displayed cytotoxicity against some leukemic cell lines in vitro. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                
  [868] "The acetate salt of Cortisone. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [869] "A synthetic hormone being studied for treatment of hot flashes in men with prostate cancer who have had both testicles removed by surgery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [870] "An isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic properties. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [871] "A complex comprised of Daunorubicin linked to DNA to enhance the topoisomerase II-mediated interaction with the DNA base pairs and reduce cardiotoxicity associated with anthracyclines. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [872] "An anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin.  Duborimycin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [873] "family of cysteine rich, 29-35 amino acid, natural antibiotic peptides."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [874] "A drug under study for the prevention of veno-occlusive disease, a rare complication of high-dose chemotherapy and stem cell transplantation in which small veins in the liver become blocked."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [875] "A radiosensitizer that targets hypoxic cells and act as oxygen subsititutes making tumor cells sensitive to radiation damage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [876] "A semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin.  Detorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.  Detorubicin is less toxic than daunorubicin. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [877] "The acetate salt form of Dexamethasone. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [878] "A trichothecene mycotoxin and potent teratogen. Anguidine inhibits initiation of protein synthesis, resulting in the death of rapidly proliferating cells.  Anguidine also has been shown to both potentiate and protect against the cytotoxic effects of other drugs.  (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [879] "A polycyclic aromatic hydrocarbon exhibiting metabolic activation and DNA adduct formation, causing mutagenicity and tumorigenicity.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [880] "A synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death.  Although less prone to glutathione inactivation compared to cisplatin, resistance to this agent has been observed in vitro due to repair of platination damage by tumor cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [881] "A drug used in photodynamic therapy that is absorbed by tumor cells.  When absorbed by cancer cells and exposed to light, photofrin becomes active and kills the cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [882] "A known colorless carcinogen liquid compound having a pungent odor used in industry and agriculture. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [883] "An aliphatic analogue of busulfan with potential antineoplastic activity.  As an alkylating agent, dimethylbusulfan induces neutropenia and has been shown to exhibit antitumor effects in some animal models.  Alkylating agents exert cytotoxic and chemotherapeutic effects by transferring alkyl groups to DNA, thereby damaging DNA and interfering with DNA synthesis and cell division. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [884] "A synthetic analogue of the naturally occurring prostaglandin F2 alpha.  Prostaglandin F2 alpha stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action on the corpus luteum. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [885] "A complex comprised of Doxorubicin linked to DNA to enhance the topoisomerase II-mediated interaction with the DNA base pairs and reduce cardiotoxicity associated with anthracyclines. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [886] "A synthetic anabolic steroid derivative of dihydrotestosterone (DHT) that is an estrogen antagonist and may be used as a palliative treatment in advanced breast cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [887] "The propionate salt form of Dromostanolone. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [888] "A synthetic quinolinecarboxylic acid analogue with antineoplastic properties.  Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis.  This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [889] "An enediyne antineoplastic antibiotic hybrid containing an anthraquinone moiety isolated from the bacterium Micromonospora chersina.  The anthraquinone moiety intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in double-strand breaks in DNA, inhibition of DNA replication and apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [890] "An heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21.  Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I and II, resulting in single-strand breaks and inhibition of DNA replication. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [891] "A topical anesthetic cream, containing lidocaine 2.5% and prilocaine 2.5%, that provides neuralgia pain relief by causing loss of cutaneous sensation through reversible blockade of conduction in nerve fibers. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [892] "A purine antimetabolite converted to Cytarabine in the body. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [893] "Staphylococcal enterotoxin A.  A superantigen and member of a family of genetically related proteins produced by Staphylococcus aureus and Streptococcus pyogenes.  An extremely potent activator of T lymphocytes when presented on MHC class II antigens."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [894] "Staphylococcal enterotoxin B.  The prototype superantigen; a member of a family of genetically related proteins produced by Staphylococcus aureus and Streptococcus pyogenes.  An extremely potent activator of T lymphocytes when presented on MHC class II antigens."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [895] "Staphylococcal enterotoxin C.  A superantigen and member of a family of genetically related proteins produced by Staphylococcus aureus and Streptococcus pyogenes.  An extremely potent activator of T lymphocytes when presented on MHC class II antigens."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [896] "Staphylococcal toxic shock syndrome toxin 1.  A superantigen with the potential to suppress plasma cell differentiation and antibody responsiveness. Potent pyrogen, induces T lymphocyte proliferation, requiring interleukin 1 release from macrophages, suppresses immunoglobulin production, enhances endotoxin shock, and enhances hypersensitivity skin reactions. Causes staphylococcal toxic shock syndrome (TSS)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [897] "A bioreductive prodrug when activated is an alkylating agent and may have cytotoxic effects in hypoxic tumor cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [898] "A phenolic antioxidant found in a number of plants such as green and black tea. It inhibits cellular oxidation and prevents free radical damage to cells. It is under study as a potential cancer chemopreventive agent. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [899] "An androgenic anabolic steroid having potent anti-estrogenic effect, which inhibits the progression of estrogen-stimulated cancers such as breast cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [900] "The parenterally-administered synthetic valerate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.  As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors.  This agent exhibits mild anabolic and metabolic properties, and increases blood coagulability. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [901] "An aqueous substance that is the sulfate salt form of estrone. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [902] "A 2-nitroimidazole with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the cytotoxicity of ionizing radiation. This agent may also be useful as an imaging agent for identifying hypoxic, drug-resistant regions of primary tumors or metastases.  (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [903] "A water soluble prodrug of Etoposide that is converted to Etoposide upon intravenous administration by dephosphorylation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [904] "A synthetic purine nucleoside antimetabolite with antineoplastic activity. Preferentially transported into malignant cells and metabolized to its active form 2-fluoro-ara-ATP by deoxycytidine kinase, fludarabine inhibits alpha DNA polymerase and RNA reductase and competes with deoxyadenosine triphosphate, resulting in inhibition of DNA primase, inhibition of DNA synthesis, and cell death. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [905] "A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties.  Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR).  DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins.  This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [906] "An anticancer drug that belongs to the family of drugs called antimetabolites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [907] "A synthetic androgen analogue.  Exemestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [908] "A drug being studied for cancer prevention.  It belongs to the family of drugs called retinoids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [909] "A drug used to reduce the amount of male hormone (testosterone) produced by the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [910] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [911] "A promising new anti-cancer drug for use against slow growing, solid tumors.  FAA functions differently from other anti-cancer agents in that it seems to interfere with blood supply to the tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [912] "The phosphate salt form of Fludarabine. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [913] "A synthetic corticosteroid. It is used to replace steroid hormones normally produced by the adrenal gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [914] "A perfluorocarbon blood substitute in trials for the treatment of severe anemia"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [915] "A synthetic nonsteroidal estrogen that competes with androgen receptors and prevents further growth of androgen dependent tumor cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [916] "A chloroethylating nitrosourea forming chloroethyl adducts at the 06 position of guanine, causing N1-guanine and N3-cytosine crosslinkages and inhibition of DNA synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [917] "A mycotoxin produced by Fusarium moniliforme.  It is a contaminant of cereals, especially corn.  It has been epidemiologically linked to high incidence of human esophageal cancer in South Africa and China and to hepatocarcinogenesis in animal models."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [918] "A substance that is being studied as a treatment for relieving hot flashes in women with breast cancer.  It belongs to the family of drugs called anticonvulsants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [919] "A drug that lowers blood calcium. Used as treatment for hypercalcemia (too much calcium in the blood) and for cancer that has spread to the bone (bone metastases)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
  [920] "A carbohydrate specific cell surface antigen expressed by human neuroblastomas, sarcomas, and melanomas.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [922] "A benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus.  Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90).  HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [923] "A soy derived isoflavonoid that inhibits protein-tyrosine kinase and topoisomerase-II activity, causing DNA fragmentation and apoptosis.  Genistein exhibits antioxidant and immunosuppressive activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [924] "A polycyclic lactone quassinoid phytochemical isolated from the seeds of Hannoa undulata and other plant species with potential antineoplastic activity.  This agent also has antiviral and antitumor properties.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [927] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [928] "The naturally occurring acetic acid form of gossypol, and an orally available polyphenolic aldehyde derived mostly from cottonseed with potential antineoplastic activity.  The biologic activities of gossypol acetic acid are similar to those of gossypol and include suppression of DNA replication, inhibition of tumor cell proliferation, and male contraceptive effects. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [929] "A drug that prevents or reduces nausea and vomiting.  It belongs to the family of drugs called antiemetics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [930] "An orally-active quinazolinone alkaloid with potential antineoplastic activity.  Halofuginone interferes with the signaling pathway of transforming growth factor beta (TGF beta) and inhibits matrix metalloproteinase 2 (MMP 2), thereby inhibiting collagen type I synthesis and inducing extracellular matrix degradation, resulting in inhibition of angiogenesis, tumor growth and invasion, and metastasis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [931] "A host-specific toxin from the maize pathogen Cochliobolus carbonum.  An inhibitor of histone deacetylase, it is a cyclic tetrapeptide containing an epoxide alpha-amino acid.  Inhibition of histone deacetylase is sensitive to mercaptoethanol treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [932] "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein cytokine hepatocyte growth factor (HGF), which is produced by the liver and the pancreas.  Endogenous HGF synthesis is stimulated by injuries affecting liver tissues.  This agent, a potent angiogenic and neurotrophic factor and a multifunctional cytokine that acts as a mitogen, motogen and a morphogen, is important for organogenesis and tissue regeneration.  Therapeutic HGF has been shown to attenuate brain ischemic injury in animal models through angiogenic and neuroprotective actions. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                     
  [933] "A bisulfamic ester which is similar in structure to busulfan and belongs to the family of drugs known as alkylsulfonate alkylating agents.  Hepsulfam forms covalent linkages with nucleophilic centers in DNA, resulting in depurination, base miscoding, strand scission, DNA-DNA and DNA-protein cross-linking, and cytotoxicity. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [934] "A benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus.  Herbimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90).  HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [935] "A hybrid polar-planar compound with potential antineoplastic activity that induces terminal differentiation, inhibits cell growth, and causes apoptosis in several tumor cell lines.  Its precise mechanism of action is unknown. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [936] "A vaccine against serotype b of the Gram-negative bacterium H. influenzae (Hib).  Hib vaccines contain polysaccharide-protein conjugate antigens that produce greater host immune responses than first-generation purified polysaccharide vaccine.  These vaccines may differ with regard to use of protein carriers, polysaccharides, diluents, and preservatives. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [937] "A cytotoxic plant alkaloid isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity.  Homoharringtonine binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation.  This agent also induces differentiation and apoptosis in some cancer cell types.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [938] "A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties.  As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes.  This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [939] "A substance that has been studied as a treatment for cancer and as a treatment for cachexia (body wasting) associated with advanced cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [940] "A monovalent radical consisting of one hydrogen and oxygen atom found in bases, carboxylic acids, and alcohols.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [941] "A serotonin 5-HT3 receptor antagonist effective for prophylaxis in chemotherapy induced nausea and vomiting."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [942] "IMREG-1 is a leukocyte-derived immunomodulator isolated from serum of HIV- negative individuals. An experimental anti-AIDS drug."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [943] "A biological response modifier produced from the bacterium Serratia marcescens that activates mononuclear cells, causing release of various cytokines. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [944] "A natural pyrrolizidine alkaloid with antineoplastic properties.  Indicine-N-oxide alkylates and crosslinks DNA. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [945] "A glucosinolate antioxidant found in cruciferous vegetables that acts as a chemopreventive agent by scavenging of free radicals from cellular oxidation and stimulation of natural detoxifying enzymes in the body. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [946] "A purine antimetabolite which is substituted for guanine in the DNA minor groove and alters the nucleic acid affinity to the peptide, interfering with DNA synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [947] "A contrast medium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [948] "A drug used to prevent or treat fungal infections.  It belongs to the family of drugs called antifungal agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [949] "A natural protein isolated from the marine mollusc keyhole limpet.  Keyhole limpet hemocyanin is an immunogenic carrier protein that, in vivo, increases antigenic immune responses to haptens and other weak antigens such as idiotype proteins. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [950] "A semisynthetic water-soluble disulfide derivative of the antineoplastic antibiotic mitomycin C.  Activated by serum and glutathione, KW-2149 causes interstrand DNA cross-links and DNA-protein cross-links, resulting in single-strand DNA breaks and inhibition of DNA synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [951] "An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [952] "A compound isolated from strains of Streptomyces griseolavendus that may exert antitumor activity by inhibition of protein tyrosine kinase and tubulin polymerization. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [953] "A formulated therapeutic analog of the endogenous lymphokine leukoregulin with potential antineoplastic activity.  Leukoregulin displays direct and indirect cytotoxicity through tumor cell lysis and enhancing tumor cell susceptibility to natural killer cell-mediated cytotoxicity.  This agent enhances membrane permeability and decreases p-glycoprotein expression, thereby promoting cytotoxic drug uptake into tumor cells.  Leukoregulin also induces the synthesis of collagenase and hyaluronan, expression and secretion of interleukin-8, and upregulates stromelysin-1 gene expression in human fibroblasts, thereby regulating extracellular matrix degradation. (NCI04)"                                                                                                                                                                                                                                                                                                         
  [954] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [955] "The two most studied groups of phytoestrogens are the lignans (products of intestinal microbial breakdown of compounds found in whole grains, fibers, flax seeds and many fruits and vegetables) and the isoflavones (found in soybeans and other legumes).  (http://www.tmc.tulane.edu/ecme/eehome/)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [956] "An indazole carboxylic acid derivative that exhibits radiosensitizing and antiparasitic effects and interferes with the multidrug resistance mechanism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [957] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [958] "A recombinant chemokine of human lymphotactin which is produced by activated progenitor T cells and characterized by specific chemotactic activity for lymphocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [959] "An antacid consisting of either a single agent (Calcium Carbonate) or combination of agents (Aluminum Hydroxide and Magnesium Hydroxide). Some formulations contain an anti-gas agent (Simethicone). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [960] "A form of cyclophosphamide that can be administered as an intrathecal infusion.  Mafosfamide is being studied as an anticancer drug.  It belongs to the family of drugs called alkylating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [961] "A normal plasma protein belonging to the collectin family. It contains a carbohydrate recognition domain at one end and a collagen-like stalk domain at the other. The presence of many carbohydrate binding sites within a single molecule of mannose-binding lectin results in very high binding to microorganisms. Upon this binding the complement system is activated through the action of associated serine proteases. Activation of the complement system leads to the deposition of complement components on the surface of the microorganisms (opsonisation) and to clearance of the microorganisms by phagocytic cells. Preclinical and clinical studies suggest that administration of the agent to deficient individuals will restore lectin function in vivo and thereby be beneficial in management of the immunodeficiency. (NCI)"                                                                                                                                                  
  [962] "An antineoplastic oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Actinosporangium bohemicum.  Marcellomycin intercalates into DNA and induces DNA crosslinks, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also induces differentiation in HL-60 promyelocytic leukemia cells by interfering with glycoprotein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
  [963] "A serotonin 5-HT3 receptor antagonist effective for prophylaxis in chemotherapy induced nausea and vomiting."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
  [964] "An anticancer drug that belongs to the family of drugs called antifungal agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [965] "A synthetic, acetate derivative of the sex hormone progesterone.  Medroxyprogesterone 17-acetate (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [966] "A synthetic, acetate derivative of the sex hormone, progesterone.  Megestrol binds to and activates specific nuclear receptors, resulting in the expression of progesterone-dependent genes. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [968] "An anabolic ether-modified form of the steroid epitiostanol. It has anti-estrogenic effect, which inhibits the progression of estrogen-stimulated cancers by competitive inhibition of estrogen binding to estrogen receptors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [969] "A cell wall fraction of bacillus Calmette-Guerin obtained from menthol extraction exhibiting immunomodulating properties used as an adjuvant in Vaccine Therapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [970] "A carbapenem antimicrobial agent used to treat a variety of serious bacterial infections by binding with penicillin-binding-proteins and inhibiting cell wall synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [971] "A diaminopyrimidine folate antagonist with potential antineoplastic activity.  Metoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism and cell growth; it also inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble metoprine is capable of crossing the blood-brain barrier. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [972] "An alkylating agent that is a member of the homologous series of dimethane sulphonic acid esters that has cumulative dose-limiting toxic effect of thrombocytopenia. (NCI))"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
  [973] "A colorless or light yellow water-soluble organic solvent that has been shown to enhance radiation-induced DNA cross-linking and the ability to induce terminal differentiation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  [974] "A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus.  Bioreduced mitomycin A generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis.  Mitomycin A is more toxic than mitomycin C due to increased and nonselective DNA cross-linking in both aerobic and hypoxic cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [975] "A podophyllic acid that inhibits topoisomerase II, causing mitotic arrest. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [976] "An imidazotetrazine alkylating agent that inhibits DNA replication by creating DNA cross-linkages. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [977] "A chloroethylating nitrosourea that causes DNA cross-linking, inhibiting DNA replication. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
  [978] "A polyamine analog being tested for the treatment of solid tumors"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [979] "A synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities.  Carboxyphenyl retinamide induces cell differentiation and inhibits tumor cell growth and carcinogenesis.  This agent may also induce cell cycle arrest in the G1 phase in some cancer cell types.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [980] "An orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic activity.  Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth.  This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis.  As an immunomodulator, miltefosine stimulates T-cells, macrophages and the expression of interleukin 3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), and interferon gamma (INF-gamma). (NCI04)"                                                                                                                                                                                     
  [981] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [982] "An oil based injectable anabolic steroid with moderate androgenic effects, promoting protein anabolism and stimulation of erythropoietin production. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
  [983] "A drug that blocks the effects of male hormones in the body.  It belongs to the family of drugs called antiandrogens."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  [984] "A nitrogen mustard agent that crosslinks with DNA, causing inhibition of DNA synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [985] "Produced by pressing olives, Olive Oil has a high content of monounsaturated fats, thought beneficial for health. Major components of the phenolic fraction of olive oil, lignans and pinoresinols are potent antioxidants present in extra virgin (first pressed) oils. Containing vitamins E and F, other antioxidant compounds, foods containing high amounts of lignan precursors may be protective against breast, colon, and prostate cancer, as well as heart diseases. Used mainly in cooking today, olive oil has been used for medicines and in cosmetics. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                       
  [986] "A derivative of aminosalicylic acid exhibiting anti-inflammatory effects when converted to mesalamine in the colon. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [987] "A dithiolethione which can prevent DNA damage induced by the mammary carcinogen dibenzo[a,l]pyrene (DBP).  Under investigation as a chemoprotectant and chemopreventive agent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  [988] "An amino acid derivative used to counteract high blood pressure caused by interleukin-2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  [989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [990] "A member of the cytokine family that regulates the proliferation and differentiation of a variety of cell types.  This family of proteins adopts a four-helix bundle fold with up-up-down-down topology and contains intramolecular disulfide bonds.  (DCB-CB, OMIM 165095, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [991] "An anticancer drug that belongs to the family of drugs called platinum compounds."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
  [992] "An anthrapyrazole antineoplastic antibiotic.  Piroxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  Although less cardiotoxic than doxorubicin, this agent exhibits a narrow spectrum of antineoplastic activity. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
  [993] "An anticancer drug that may inhibit cancer cell growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
  [994] "A isoquinoline alkaloid from amaryllis with antineoplastic activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [995] "calcium-regulating hormone with endocrine, paracrine, and autocrine actions in bone; can cause hypercalcemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [996] "A chloroethylnitrosourea compound that inhibits DNA synthesis by cross linking and may be associated with pulmonary, hepatic, and hematologic toxicity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  [997] "A cytostatic compound that has been used as an antineoplastic agent against ovarian carcinoma. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
  [998] "An anticancer drug that belongs to the family of drugs called alkylating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  [999] "One of the principal metabolites of Hexylmethylmelamine"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1000] "A nitrogen mustard compound; alkylating antineoplastic agent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1001] "Hydroxybenzene; Carbolic Acid. Used as a germicidal agent and as an intermediate in chemical synthesis.  Highly toxic; corrosive to the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1002] "Phosphatidylinositol 4,5-Diphosphate; PIP2.  A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate (IP3) and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1003] "A synthetic organic analogue of inorganic pyrophosphate with antiviral properties.  Foscarnet (trisodium phosphonoformate) selectively blocks the pyrophosphate binding site of virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases.  Because this agent crosses the blood brain barrier, it may be used in the treatment of viral infections of the CNS.  (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1004] "Compounds from plant sources with estrogen-like activities"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1005] "A polyhydroxylated stilbene extract from the seeds of Euphorbia lagascae, which inhibits protein tyrosine kinase Syk and induces apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1006] "A nitroimidazole hypoxic cell sensitizer that selectively binds to thiol-containing proteins in hypoxic cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1007] "A derivative of doxorubicin, an anthracycline."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1008] "A nuclease-resistant complex of polyriboinosinic-polyribocytidylic acid, poly-L-lysine, and carboxymethylcellulose."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1009] "A synthetic long-acting polymer derivative of the female sex hormone estradiol.  As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors.  Estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability.  Administration of polyestradiol phosphate leads to the marked decrease of testosterone levels and may exhibit a bone mass-preserving effect in patients with prostatic cancer. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1010] "A modified form of asparaginase, an anticancer drug that belongs to the family of drugs derived from enzymes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1011] "Polysialic acid is the glycosydic moiety of the neural cell adhesion molecule (NCAM) that mediates the cell-cell interaction and consequently cell growth. Neuroblasmas and cell lines derived from these tumors bear polysialyted NCAM. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1012] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1013] "A recombinant form of the endogenous polypeptide hormone that exerts immunomodulatory effects primarily on mononuclear cells.  Prothymosin alpha stimulates the production of various cytokines including granulocyte/macrophage colony stimulating factor (GM-CSF) alpha, gamma interferon (IFN) and interleukins such as IL-2.  This agent may also increase some tumor antigens expression, thus inducing better T lymphocyte responses to tumor cells.  Combined with chemotherapy, prothymosin alpha may exhibit significant anti-tumor effects.  This agent also helps to regenerate lymph node and bone marrow cells after treatment with certain toxic chemotherapeutics. (NCI04)"                                                                                                                                                                                                                                                                                                          
 [1014] "Protein-bound polysaccharide from the mushroom Coriolus versicolor (Shitake); a biological response modifier with antitumor activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1015] "An isoflavone from Pueraria thunbergiana, which induces differentiation and apoptosis in cancer cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1016] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1017] "An anticancer drug."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1018] "A nucleoside analog that interferes with de novo synthesis of uridine nucleotides.  It inhibits orotidine-5'-phosphate decarboxylase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1019] "A parent class of polycyclic aromatic hydrocarbons containing four fused rings. (IUPAC 1998)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1020] "cis-4-amino-5-chloro-N-(1-(3- (p-fluorophenoxy)propyl)-3-methoxy-4- piperidyl)-o-anisamide; peristaltic stimulant under clinical evaluation for constipation, gastroparesis, intestinal pseudoobstruction, and other GI motility disorders."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1021] "A member of the IL-8 superfamily of cytokines and released from platelets and activated T-cells, RANTES is a selective chemoattractant for eosinophils, monocytes, and T-lymphocytes.  RANTES is one of the ligands for chemokine receptor CCR5. RANTES expression in peripheral lymphocytes increases exponentially following mitogenic or antigenic stimulation.  RANTES is one of the major HIV-suppressive factors produced by CD8-positive T-cells.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1022] "A drug used to help prevent rejection of organ and bone marrow transplants by the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1023] "An anticancer drug that belongs to the family of drugs called antineoplastic antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1024] "A capsaicin"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1025] "Resveratrol, an antioxidant phytoalexin found in grapes and other food products, acts as an antimutagen and has cancer chemopreventive activity in three major stages of carcinogenesis.  Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); it mediates anti-inflammatory effects and inhibites cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and it induces promyelocytic leukemia cell differentiation (anti-progression activity).  Resveratrol turns off the NF-kappa B gene in cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1026] "A naturally-occurring fatty acid ester form of retinol (vitamin A) with potential antineoplastic and chemopreventive activities.  Retinyl acetate binds to and activates retinoid receptors, inducing cell differentiation and decreasing cell proliferation.  This agent also inhibits carcinogen-induced neoplastic transformation in some cancer cell types and exhibits immunomodulatory properties.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1027] "A drug being studied in cancer prevention.  It belongs to the family of drugs called retinoids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1028] "An anticancer drug isolated from a fungus. It is similar to the family of drugs called vinca alkaloids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1029] "A drug that belongs to a family of drugs called nonsteroidal anti-inflammatory agents. It is being studied in cancer prevention."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1030] "A medium energy beta-emitting radioisotope in a chelate form (ethylenediaminetetramethylenephosphonic acid).  It concentrates in bone tissue; used to provide relief to patients with painful bone metastases"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1031] "A triazole antifungal agent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1032] "An anti-HIV agent that exerts its effect by inhibiting glucosylceramide synthase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1033] "3-Selenyl-L-alanine. A naturally occurring amino acid in both eukaryotic and prokaryotic organisms. It is found in tRNAs and in the catalytic site of some enzymes. The genes for glutathione peroxidase and formate dehydrogenase contain the TGA codon, which codes for this amino acid. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1034] "A drug being studied in the treatment of cancer.  It belongs to the family of drugs called antiestrogens.  Atamestane blocks the production of the hormone estrogen in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1035] "A bacterial toxin produced by Shigella dysenteriae and by some strains of E. coli that inhibits protein synthesis by blocking the interaction of ribosomal RNA with peptide elongation factors.  The non-catalytic beta subunit of Shiga toxin may be useful as a fusion vector for induction of antigen-specific cytotoxic T lymphocyte responses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1036] "A mucin glycosylated epitope for potential use as a marker for colon cancer risk in ulcerative colitis and as antigen in immunotherapy for cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1037] "A quassinoid phytochemical isolated from Simaba multiflora, Quassia africana and other plant species with potential antineoplastic activity.  This agent also has antimalarial and antiviral properties.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1038] "A crystalline powder essential for the metabolism and development of plants and animals as a cofactor for enzymes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1039] "The sodium salt of selenium.  As a trace mineral that is toxic in high doses, selenium is a cofactor for glutathione peroxidase, an anti-oxidant enzyme that neutralizes hydrogen peroxide.  Selenium may be chemoprotective for certain cancers, particularly prostate cancer.  High dietary supplementation with sodium selenate may inhibit the progression of hormone-refractory prostate cancer due, in part, to an antiangiogenesis effect. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1040] "A water soluble salt and reducing agent that reacts with oxidizing agents.  Although its exact mechanism of action is unknown, thiosulfate likely provides an exogenous source of sulfur, thereby hastening the detoxification of cyanide through the enzyme rhodanese (thiosulfate cyanide sulfurtransferase) which converts cyanide to the relatively nontoxic, excretable thiocyanate ion.  In addition, this agent neutralizes the reactive alkylating species of nitrogen mustard, thereby decreasing skin toxicity from nitrogen mustard extravasations. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1041] "A biodegradable starch microsphere used in arterial embolization."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1042] "An organometallic germanium compound, with antineoplastic activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1043] "A bifunctional nitrogen alkylating agent that contains a lipophilic hydantoin group that might serves as a carrier across the blood brain barrier and effective against central nervous system tumors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1044] "A synthetic derivative of cyclohexane sulfatoplatinum with antineoplastic properties.  Spiroplatin induces DNA cross-links, thereby inhibiting DNA replication and RNA and protein synthesis. Similar to other platinum compounds, this agent has been shown to be mutagenic and carcinogenic. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1045] "A tyrosine kinase inhibitor that inhibits phospholipase D activity in human neutrophils at a site between the receptor and phospholipase. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1046] "Lysate of broth culture of two strains of coagulase positive Staphylococcus aureus with polyvalent Gratia bacteriophage; used in treatment of Hidradenitis Suppurativa"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1047] "A drug that belongs to the family of drugs called alkaloids. It is being studied in the treatment of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1048] "A radioactive pharmaceutical agent that emits local radiation in areas of active bone formation to provide adjunct relief for metastatic bone pain. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1049] "A drug that is being studied in the treatment and prevention of cancer.  It has been shown to cause apoptosis (cell death) in cancerous and precancerous cells by acting through a group of cellular enzymes called cGMP phosphodiesterases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1050] "A sulfonamide serotonin agonist and vasoconstrictor that acts selectively at 5HT1 receptors and is used for the treatment of migraine in adults."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1051] "Pressed from sunflower seeds (Helianthus annus), Sunflower Oil has a high content of beneficial monounsaturated fats, and antioxidant vitamins E and F, as well as triglycerides and linoleic acids. Used mainly in cooking today, sunflower oil has been used for medicines and in cosmetics. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1052] "A beta-lactamase inhibitor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1053] "A radiolabeled substance that is used in cancer diagnosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1054] "A triazene analog of dacarbazine with antineoplastic activity.  As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC) whose cytotoxicity is due primarily to methylation of DNA at the O6 and N7 positions of guanine; this DNA methylation inhibits DNA replication.  Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered orally and penetrates well into the central nervous system. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                          
 [1055] "One of 800 terephthalanilides synthesized and tested preclinically in the late 1950's and early 1960's.  Chosen in the 1990's for further clinical investigation by the NCI's Project for the Review of Old Drugs because of its structure and activity spectrum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1056] "An eight-carbon ester form of Testosterone. The number of ester carbon atoms correlate with the half-life of the prodrug. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1057] "A long acting parenteral ester formulation of testosterone. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1058] "A four-carbon ester form of Testosterone. The number of ester carbon atoms correlate with the half-life of the prodrug. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1059] "An eleven-carbon ester form of Testosterone. The number of ester carbon atoms correlate with the half-life of the prodrug. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1060] "1,2-diaminocyclohexane tetrachloroplatinum(IV), an antineoplastic platinum compound."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1061] "A cytotoxic purine antagonist that has both immunosuppressive and antiarthritic activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1062] "An antimitotic alkaloid that binds to microtubules and inhibits tubulin polymerization and induces apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1063] "A synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha.  Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity. (NCI04)"                                                                                                                                                                                                                                             
 [1064] "An anticancer drug being studied to stop cell growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1065] "An anticancer drug that is also used in cancer prevention. It belongs to the family of drugs called photosensitizing agents. Also called SnET2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1066] "An anticancer drug that belongs to the family of drugs called antiestrogens. Toremifene blocks the effect of the hormone estrogen in the body. It may help control some cancers from growing, and it may delay or reduce the risk of cancer recurrence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1067] "A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called alkylating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1068] "A folic acid antagonist with a sulfonyl fluoride group that exerts antitumor activity by irreversibly inhibiting dihydrofolate reductase. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1069] "Tri-n-butyl phosphate, Bu3-P, TBP.  Industrial chemical; used as a plasticizer, in hydraulic fluid, as a solvent and extractant for metal ions, and as a heat exchange agent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1070] "A triglyceride drug that may inhibit cell growth and induce cell differentiation. Differentiating agents may be effective in changing cancer cells back into normal cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1071] "A fungistatic antibiotic isolated from the culture broth of Streptomyces platensis.  It is a highly specific inhibitor of histone deacetylase; its effects on cell proliferation and differentiation are attributed to this inhibitory action."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1072] "An agent that inhibits purine nucleoside synthesis and causes antiproliferative effect against tumors and retroviral infections. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1073] "A synthetic derivative of androstane with adrenocortical suppressive properties.  No longer commercially available in the U.S., trilostane reversibly inhibits 3s-hydroxysteroid dehydrogenase/delta 5-4 isomerase in the adrenal cortex, resulting in decreased synthesis of mineralocorticoids and glucocorticoids and decreased conversion of pregnenolone to progesterone. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1074] "A less toxic derivative of colchicine that has antiproliferative activity against solid tumors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1075] "A drug that belongs to the family of drugs called antimetabolites. It is used in the treatment of pneumocystis carinii pneumonia and is being studied in the treatment of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1076] "An antiestrogen that has been studied in advanced breast cancer. Clinical development of Trioxifene has not proceeded because of lack of superior results over tamoxifen and side effect profile. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1077] "A hormonal anticancer drug that belongs to the family of drugs called gonadotropin-releasing analogues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1078] "An alkylating antineoplastic agent; cyclophosphamide analog."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1079] "A protein/sugar complex found on the surface of many cancer cells, including breast, colon, and pancreatic cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1080] "An alkylating agent that bind to the DNA minor groove in a sequence-specific manner and form covalent adducts with adenines, resulting in the inhibition of DNA replication and induction of apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1081] "An anticancer drug that belongs to the family of drugs called staurosporine analogues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1082] "A recombinant therapeutic agent which is chemically identical to or similar to endogenous vascular endothelial growth factor (VEGF).  Produced by a wide variety of cell types, endogenous VEGF is a homodimeric, glycosylated protein that is a highly specific mitogen for vascular endothelial cells; significantly influences vascular permeability; appears to play a role in neovascularisation under physiological conditions; is a potent chemoattractant; has pro-coagulatory activities; and is hypoxia-inducible.  Therapeutic VEGF may be used to induce angiogenesis in the treatment of ischemic conditions and may have a role in stimulating nerve regeneration. (NCI04)"                                                                                                                                                                                                                                                                                                           
 [1083] "An indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1084] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1085] "An anticancer drug that belongs to the family of plant drugs called vinca alkaloids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1086] "Orally active, semisynthetic vinca alkaloid."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1087] "A potent fungal metabolite isolated from Penicillium wortmannin that selectively inhibits phosphatidylinositol 3-kinase and affects the signal transduction pathway. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1088] "An antidepressant drug that is being evaluated for the treatment of hot flashes in women who have breast cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1089] "An antibiotic discovered in China whose chief component is bleomycin.  It has an antiangiogenesis effect."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1090] "A substance required for cell growth and tissue repair.  It is being studied as a way to prevent or decrease mucositis caused by radiation therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1091] "Hazardous or potentially hazardous biological agents, like viruses, recombinant DNA, and blood products."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1092] "A second-generation platinum compound with a broad spectrum of antineoplastic properties.  Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue.  This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links.  These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition.  This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04)"                                                                                                                                                                                                                                                                                                  
 [1093] "A class of substances that are produced by cells of the immune system and can affect the immune response. Cytokines can also be produced in the laboratory by recombinant DNA technology and given to people to affect immune responses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1094] "A polysulfated sugar that has activity against herpes simplex virus (HSV) and human immunodeficiency virus. May be used to induce colorectal cancer in mice. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1095] "Endothelin-1, encoded by the EDN1 gene is a potent, 21-amino acid vasoconstrictor peptide produced by vascular endothelial cells. Endothelin-1 inhibits active Na-K transport by inhibiting Na(+)-K(+)-ATPase in intact renaltubular epithelial cells. (From OMIM, PubMed and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1096] "A recombinant agent, which is chemically identical to or similar to the endogenous cytokine transforming growth factor-beta-2 (TGF-beta-2). TGF-beta-2 modulates cell growth and immune function and may promote or inhibit tumor growth, depending on the tumor cell type; this agent may also suppress host immune system recognition of and/or response to tumor cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1097] "A 25 kD glycoprotein cytokine involved in the regulation of differentiation and formation of hematopoietic stem cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1098] "A recombinant acidic glycoprotein that stimulates proliferation, differentiation and survival of progenitor cells. Current use: enhances the functional activities of mature myeloid effector cells including monocytes and granulocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1099] "A cytokine that activates neutrophils and attracts neutrophils and T-lymphocytes. It is released by several cell types including monocytes, macrophages, T-lymphocytes, fibroblasts, endothelial cells, and keratinocytes by an inflammatory stimulus. IL-8 is a member of the beta-thromboglobulin superfamily and structurally related to platelet factor 4. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1100] "A recombinant form of Colony Stimulating Factor-1, produced by various cell types and is involved with the development and function of monocytes and macrophages"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1101] "Antisense Oligonucleotides, short synthetic segments of DNA or RNA, designed with a sequence complimentary to a specific mRNA that target and bind with mRNA, causing inhibition of translation or overexpression of the protein encoded by the mRNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1102] "RNA that contains an intron sequence which has an enzyme-like catalytic activity. This intron sequence has been shown to fold up to form a complex surface that can function like an enzyme in reactions with other RNA molecules and thus synthesize new molecules even in the absence of protein. Synthetic ribozymes can be engineered to specifically cleave a target RNA sequence causing expression down regulation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1103] "A recombinant form of the endogenous Transforming Growth Factor-Beta 1, a protein involved with the regulation of cell proliferation and differentiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1104] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1105] "A streptomycin A-related cyclic depsipeptide isolated from the bacterium Streptomyces virginiae and other Streptomyces bacterial species.  Virginiamycin M1 binds to and inhibits assembly of 50S and 30S ribosomes, thereby preventing protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1106] "A streptomycin B-related cyclic depsipeptide isolated from the bacterium Streptomyces virginiae and other Streptomyces bacterial species.  Virginiamycin S1 binds to and inhibits the formation of 50S ribosomes, thereby preventing protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1107] "A type of altered DNA base caused by oxidative DNA damage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1108] "A drug that belongs to the family of drugs called angiogenesis inhibitors. It prevents the growth of new blood vessels into a solid tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1109] "An amphiphilic compound that exhibits a direct phototoxic effect, thereby inducing tumor necrosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1110] "A pentapeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity.  Binding to tubulin, Dolastatin 10 inhibits microtubule assembly, resulting in the formation of tubulin aggregates and inhibition of mitosis.  This agent also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1111] "An enediyne antineoplastic antibiotic hybrid containing an anthranilate moiety.  Esperamicin A1 is isolated from the bacterium Actinomadura verrucosospora.  The anthranilate component of esperamicin A1 intercalates DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-stranded breaks in DNA and apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1112] "A recombinant form of human I-309, an inflammatory CXC cytokine secreted by activated T lymphocytes that appears to be an inducer of angiogenesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1113] "(in-ter-LOO-kin) IL-11. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease) that stimulates immune response and may reduce toxicity to the gastrointestinal system resulting from cancer therapy. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases. Also called oprelvekin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1114] "A complex of polyethylene glycol and interleukin-2 that is administered intratumorally to stimulate immune response against the cancer cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1115] "An inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase, thereby inhibiting signal transduction. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1116] "A drug that may improve the response of cancer cells to chemotherapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1117] "A recombinant form of the heparin-binding cytokine pleiotrophin.  Developmentally regulated, pleiotrophin functions as a growth factor during embryogenesis and the neonatal period, contributing to trophoblast formation, organ development, bone formation, and early brain development by inducing the differentiation and proliferation of neuronal tissue.  Expressed in certain tumor cell types, this agent may stimulate tumor cell growth, angiogenesis, and metastasis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1118] "A synthetic polypeptide based on the arg-gly-asp (RGD) sequence present in some cell adhesion molecules.  Displays antimetastatic activity in model systems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1119] "A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 4 (FGF-4). Therapeutic FGF-4 induces vascular permeability, angiogenesis, and arteriogenesis and has potential uses in the treatment of peripheral vascular disease. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1120] "A methanesulfonate salt form, a staurosporine analog that inhibits protein kinase C and induces apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1121] "A drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1122] "Drugs that are manufactured and distributed by various pharmaceutical companies under their generic name or a brand name and do not have patent protection.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1123] "A radioprotective agent that belongs to the family of drugs called prostaglandins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1124] "2,4-diamino-5-methyl-6-(3,4,5-trimethoxy anilinomethyl)quinazoline; one of the most widely used cancer chemotherapeutic agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1125] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1126] "neurotoxin used to induce experimental CNS and sympathetic neural lesions that model aging and various nervous disorders; also used to induce behavioral circling and as a potential antineoplastic for neuroblastoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1127] "A substance that is used to treat depression, and to help people quit smoking.  It belongs to the family of drugs called antidepressants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1128] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1129] "A drug that belongs to a family of drugs called gonadotropin-releasing hormone analogues. It is used to block hormone production in the ovaries or testicles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1130] "A cytokine derived from helper T-lymphocytes, B-lymphocytes, and monocytes that inhibits the production of cytokines by activated T-cells, increases the viability of B-cells, induces expression of class II major histocompatibility complex genes, and inhibits mononuclear cell inflammation.  IL-10 is a co-regulator of mast cell growth and shows extensive homology with the Epstein-Barr virus BCRFI gene.  (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1131] "A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1132] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1133] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1134] "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-9 (IL-9). Produced by CD4+ lymphocytes, IL-9 stimulates the proliferation of T-helper cells and the growth of mast cells and megakaryoblasts.  This agent also enhances the growth of some leukemia cell lines and may play a role in the pathogenesis of Hodgkin's disease and large cell anaplastic lymphoma. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1135] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1136] "The hydrochloride salt of the anthracycline antineoplastic antibiotic doxorubicin.  Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1137] "An agent that inhibits platelet aggregation and reduces coagulation in the circulatory system. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1138] "An attenuated strain of Mycobacterium bovis that is used as an immunoadjuvant in Vaccine Therapy against tuberculosis and cancer.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1139] "Molecular cloning vector.  Any DNA molecule capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. They are or are derived from plasmids, bacteriophages, or viruses and are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain genetic markers to facilitate their selective recognition."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1140] "A pyrimidine nucleoside component of DNA comprised of thymidine linked by its N1 nitrogen to the C1 carbon of deoxyribose.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1141] "A family of compounds derived from Podophyllum peltatum.  These agents induce apoptosis by inhibiting topoisomerase II, thereby causing double strand breaks in DNA. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1142] "A drug that belongs to the family of drugs called bisphosphonates. Bisphosphonates are used as treatment for hypercalcemia (abnormally high levels of calcium in the blood) and for cancer that has spread to the bone (bone metastases)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1143] "A bisdioxopiperazine with antineoplastic activity and cardioprotective properties.  After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, thereby preventing the metal-catalyzed formation of reactive oxygen radicals produced by anthracycline antibiotics such as doxorubicin.  This agent also inhibits the catalytic activity of topoisomerase II, resulting in cell growth inhibition. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1144] "A water-soluble vitamin essential for metabolism and normal physiological functions and present in three forms: pyridoxine, pyridoxal, and pyridoxamine.  B6 vitamins are converted in vivo to pyridoxal phosphate, a cofactor necessary for the synthesis of amino acids, neurotransmitters, and sphingolipids.  More than100 enzymes involved in protein metabolism require vitamin B6 as a cofactor. This vitamin is essential to red blood cell, nervous system, and immune systems functions and helps maintain normal blood glucose levels.  Vitamin B6 is found in a wide variety of foods including cereals, beans, meat, poultry, fish, and some fruits and vegetables. (NCI04)"                                                                                                                                                                                                                                                                                                           
 [1145] "A synthetic derivative of nicotinamide adenine dinucleotide (NAD). Aminothiadiazole competitively inhibits inosine 5-monophosphate dehydrogenase, thereby disrupting the regulation of cell proliferation and differentiation in a number of cells.  This agent is also a selective human adenosine A3 receptor antagonist. . (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1146] "A purine nucleoside antimetabolite analogue. Cladladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis.  Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. . (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1147] "A cholinergic agonist which binds to muscarinic receptors to increase secretions of the exocrine glands. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1148] "3,4-dihydroxybenzohydroxamic acid.  An inhibitor of ribonucleotide reductase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1149] "A three substituted fluoranthene derivative of the 2-(arylmethylamino)-1,3-propanediol family that intercalates with DNA, causing inhibition of DNA synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1150] "A semisynthetic analogue of the anthracycline antineoplastic antibiotic doxorubicin.  Valrubicin exhibits antineoplastic properties through a variety of mechanisms.  Similar to related anthracyclines antibiotics, valrubicin interacts with topoisomerase II, leading to inhibition of DNA replication and repair and RNA and protein synthesis.  In addition, valrubicin accumulates in the cell cytoplasm where it inhibits protein kinase C (PKC).  Valrubicin is less cardiotoxic than doxorubicin when administered systemically; applied topically, this agent shows excellent tissue penetration. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                
 [1151] "A kind of Protein tyrosine kinase inhibitor involved in cell proliferation and differentiation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1152] "A topoisomerase II inhibitor of the anthrapyrazole family that causes covalent cross-links in DNA of tumor cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1153] "An amino acid mixture for nutritional support"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1154] "An acyloxyalkyl ester prodrug of butyric acid. Pivaloyloxymethylbutyrate inhibits histone deacetylase, resulting in cell differentiation, cell growth inhibition, and apoptosis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1155] "A drug that belongs to the family of drugs called bisphosphonates. Pamidronate is used as treatment for abnormally high levels of calcium in the blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1156] "A L-leucine derivative of sarkolysin that act an alkylating agent. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1157] "Azimexon (2-cyanaziridinyl-2-carbamoyl-aziridinyl-1-propane) is a derivative of 2-cyanaziridine. Immunostimulant which shows therapeutic effects in tumor models and experimental infections in vitro, enhancing T lymphocyte transformation and phagocytosis. The mode of action of azimexon is unknown. It has been suggested that azimexon may alkylate DNA. In cancer patients it increases leukocytosis, blood active T rosettes, T4/T8 ratio, and is used as an adjuvant to chemotherapy in the treatment of melanoma and myeloma. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1158] "The benzoate of a estradiol-chlorambucil conjuagte. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1159] "A recombinant therapeutic agent which is chemically identical to or similar to an endogenous glycoprotein which inhibits pituitary production of follicle-stimulating hormone (FSH).  Produced and secreted by the testis or ovarian follicle, endogenous inhibin B contributes to the control of gametogenesis, embryonic and fetal development, and hematopoiesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1160] "A purine antagonist that interferes with DNA synthesis and has activity against tumor cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1161] "A mineral compound that is used to treat duodenal and gastric ulcers associated with Helicobactor pylori. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1162] "Recombinant therapeutic agents chemically identical to or similar to endogenous nerve growth factors (neurotrophins) that play vital roles in the development of the nervous system.  Brain-derived growth factors may also regulate hematopoiesis and immune cell function.  Examples of brain-derived growth factors include nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1163] "A drug that prevents or reduces nausea and vomiting.  It belongs to the family of drugs called antiemetics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1164] "An anticancer drug that interferes with the DNA in cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1165] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1166] "Carbetimer (carboxyimamidate) is a low molecular weight derivatized copolymer of ethylene and maleic anhydride.  It has demonstrated antitumor activity against several animal models.  It has calcium chelation activity but seems to inhibit growth of sensitive cells by disrupting nucleoside uptake and metabolism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1167] "An anticancer drug that belongs to the family of drugs called mitotic inhibitors. Also called CI-980."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1168] "Connective Tissue-Activating Peptide III is a platelet-derived growth factor that stimulates in fibroblasts mitogenesis, extracellular matrix synthesis, glucose metabolism, and plasminogen activator synthesis through interaction with a GPCR.  It is present in platelet granules, released by inducers of platelet aggregation, and is chemoattractant for fibroblasts, presumably for repair.  Pro-platelet basic protein is the precursor of platelet basic protein (PBP) and CTAP III.  Upon platelet activation they are released and processed in plasma to beta-thromboglobulin and neutrophil-activating peptide-2.  The thrombocidins TC1 and TC2 are variants of NAP2 and CTAP III, respectively.  TC1 and TC2 differ from NAP2 and CTAP III by their bactericidal and fungicidal properties, which apparently do not involve pore formation.  (from OMIM 121010 and NCI)"                                                                                                            
 [1169] "A synthetic cyclopentenyl antimetabolite analogue of cytidine with antineoplastic activity and antiviral activity.  Cyclopentenyl cytosine competitively inhibits cytidine triphosphate (CTP) synthetase, thereby depleting cytidine pools and inhibiting DNA synthesis.  This agent may also induce differentiation of some tumor cell types. Cyclopentenyl cytosine's antiviral activity is broad-spectrum. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1170] "A cytostatic agent that interferes with DNA synthesis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1171] "Depudecin is a fungal metabolite that reverts the rounded phenotype of NIH 3T3 fibroblasts transformed with v-ras and v-src oncogenes to the flattened phenotype of the non-transformed parental cells. The mechanism of de-transformation induced by this agent had not been determined. However, depudecin has been demonstrated to inhibit histone deacetylase (HDAC) activity effectively both in vivo and in vitro."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1172] "A sodium phosphate salt form of Dexamethasone. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1173] "A synthetic bifunctional quinone derivative with potential antineoplastic activity. Diaziquone alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.  This agent can also form free radicals, thereby initiating DNA damage via DNA strand breaks.  Due to its lipophilicity, diaziquone readily crosses the blood brain barrier. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1174] "A cyclic depsipeptide extracted from the Caribbean tunicate Trididemnin cyanophorum.  Didemnin B activates caspase, thereby inducing apoptosis, and prevents eukaryotic elongation factor 2 (eEF-2)-dependent translocation, thereby inhibiting protein synthesis.  This agent also has immunosuppressive and antiviral properties. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1175] "A drug that belongs to the family of drugs called chemoprotective agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1176] "A copolymer conjugate of the anthracycline antineoplastic antibiotic doxorubicin and the water-soluble polymer N-(2-hydroxypropyl) methacrylamide (HPMA).  Conjugation with HPMA improves the therapeutic effects of doxorubicin, by promoting drug accumulation inside tumors, while decreasing systemic toxicity.  Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                    
 [1177] "A derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties.  As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1178] "Epithelial neutrophil activating peptide-78.  A 78 amino acid member of the CXC family of chemokines, produced and secreted upon stimulation by interleukin 1 beta or tumor necrosis factor alpha.  Stimulates chemotactic migration of neutrophils, monocytes, lymphocytes, and fibroblasts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1179] "A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 6 (FGF-6).  Because of the mitogenic effects of FGF-6 on fibroblasts and endothelial cells and the stimulatory effects of FGF-6 on muscle stem cell migration, therapeutic FGF-6 has a potential role in wound healing and muscle regeneration. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1180] "A recombinant form of the heparin-binding fibroblast growth factor 5 (FGF-5).  FGF-5 may function as a growth factor during embryogenesis and may have a role in wound repair throughout adulthood because of its mitogenic effects on fibroblasts and endothelial cells.  Overexpressed in certain tumor cell types, this agent may promote tumor growth and angiogenesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1181] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1182] "An anti-tumor antibiotic isolated from the bacterium Streptomyces pulveraceus. Fostriecin inhibits topoisomerase II catalytic activity, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis in various malignant cell types.  This agent also inhibits serine/threonine protein phosphatase type 2A in some tumor cell types, thereby interfering with cellular proliferation and differentiation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1183] "A marine sponge metabolite from Cymbastela cantharella that has anti-tumor activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1184] "A drug that belongs to the family of drugs called gonadotropin-releasing hormone analogues. Goserelin is used to block hormone production in the ovaries or testicles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1185] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1186] "A complex macrolide polyether from marine sponge genera, such as Halichondria, Axinella, Phakellia, and Lissodendoryx that binds to tubulin, thereby inhibiting mitosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1187] "A drug used in photodynamic therapy that is absorbed by tumor cells. When exposed to light, it becomes active and kills the cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1188] "An anti-HIV agent.  May also function as an antineoplastic agent"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1189] "A drug that blocks estrogen activity in the body and is used in the therapy of estrogen-dependent tumors such as breast cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1190] "(in-ter-LOO-kin) IL-12. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease) that enhances the ability of the immune system to kill tumor cells and may interfere with blood flow to the tumor. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1191] "A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.  Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme.  One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death.  Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent. (NCI04)"                                                                                                                                                                                                                                                                        
 [1192] "A fungal alkaloid from Nocardiopsis species, which inhibits protein kinase C. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1193] "Platar is a liposomal formulation of a novel platinum drug designed to overcome the toxicity and drug resistance that currently limit the usefulness of platinum"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1194] "Leukemia Inhibitory Factor (LIF) affects many systems, including hematopoietic, embryonic, bone, hepatic, neuronal, and fat tissues. It inhibits the maturation of normal blood cells. LIF induces MHC class I HLA-G expression by cytotrophoblasts, which plays an essential role in implantation and facilitates immune tolerance of the conceptus at the maternal-fetal interface. Cytotrophoblast cells express LIF receptors. Ureteric bud cells secrete factors, including LIF, that convert kidney mesenchyme to epithelia, which then forms nephrons. The metanephric mesenchyme expresses LIF receptors. LIF and BMP2 cytokines signal through different receptors and transcription factors (STATs and SMADs) and act in synergy on neural progenitors to induce astrocytes. Formation of a STAT3/SMAD1 complex, bridged by p300, mediates cooperative signaling of LIF and BMP2 and induction of astrocytes from neuronal progenitors. (From OMIM and NCI)"                              
 [1195] "A synthetic cannabinoid analogue of delta (9)-tetrahydrocannabinol (delta(9)-THC) with antiemetic and anti-analgesic properties. Although its precise mechanism of action is unknown, levonantradol appeasr to bind and activate the cannabinoid receptors CB1 and/or CB2. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1196] "A dye used in sentinel lymph node mapping."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1197] "A cancer specific antigen expressed by the melanoma antigen gene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1198] "A combination drug containing hydrochlorothiazide and triamterene used as a diuretic."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1199] "A semisynthetic derivative of the anthracycline antineoplastic antibiotic nogalamycin.  Menogaril intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent is less cardiotoxic than doxorubicin. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1200] "An inhibitor of Topoisomerse II, interfering with DNA replication."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1201] "A recombinant therapeutic agent which is chemically identical to or similar to endogenous macrophage inflammatory protein-1, a member of the CC chemokine family produced by activated macrophages.  Macrophage inflammatory protein-1 alpha activates granulocytes and induces pro-inflammatory cytokine synthesis.  The addition of macrophage inflammatory protein-1 alpha to a vaccine consisting of a DNA immunogen or a pro-inflammatory peptide may enhance vaccine-induced host immune anti-tumor responses. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1202] "A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus.  Bioreduced mitomycin B generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1203] "A chemokine that is a chemoattractant for human monocytes and may also cause cellular activation of specific functions related to host defense. It is produced by leukocytes of both monocyte and lymphocyte lineage and by fibroblasts during tissue injury. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1204] "A synthetic muramyl tripeptide structurally related to a bacterial cell wall constituent that activates monocytes and macrophages, causing induction of multiple cytokines (Il-1 alpha and beta, Il-7, IL-8, IL-12, and Tumor Necrosis Factor) and tumoricidal activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1205] "The ditartrate salt of a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic properties.  Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with vinorelbine's neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity.  This agent is also a radiation-sensitizing agent. (NCI04)"                                                                                                                                                                                                                                                             
 [1206] "family of polypeptide growth factors produced by peripheral target tissues as well as the nervous system, which are critical to neuronal growth, regeneration, survival, and differentiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1207] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1208] "An anticancer drug that is being studied to increase the effectiveness of the chemotherapy drug fluorouracil."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1209] "A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus.  Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA.  This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1210] "The sulfate salt of the bleomycin analogue peplomycin.  Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA.  This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1211] "An alkylating agent, inhibits DNA synthesis and proliferation of tumor cells in culture."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1212] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1213] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1214] "Substances that inhibit one or more kinase enzymes and have applications as anticancer agents and biological tools in cell signalling.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1215] "A drug that belongs to the family of drugs called cyclosporine analogues. It is used with chemotherapy to prevent or overcome the resistance of tumor cells to some anticancer drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1216] "A drug that blocks the effects of estrogen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1217] "A tyrosine kinase inhibitor that selectively inhibits epidermal growth factor receptor, epidermal factor-stimulated HER14 cell proliferation, and tumor growth in vivo. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1218] "A semisynthetic ansamycin antibiotic with potent antimycobacterial properties.  Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1219] "A penicillin antibiotic that inhibits peptidoglycan synthesis involved in bacterial cell, hence inhibiting cell wall biosynthesis causing the bacteria to lyse. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1220] "A therapeutic hematopoietic glycoprotein cytokine.  Therapeutic recombinant human stem cell factor (rhSCF) binds to c-kit and stimulates the growth of peripheral blood progenitor cells (PBPCs) and may promote bone marrow recovery after myeloablative therapies and procedures. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1221] "A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity.  Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division.  This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1222] "A substance used to treat bacterial infections.  It belongs to the family of drugs called antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1223] "A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.  Topotecan inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death.  Because ongoing DNA synthesis is necessary for topotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1224] "A mesylate salt form of trioxifene. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1225] "A cardiotonic quinolinone derivative, that suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin dependent kinase activity in p53-mediated cell cycle arrest. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1226] "An antineoplastic alkylating agent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1227] "The acetate salt of a synthetic decapeptide analog of luteinizing hormone-releasing hormone (LHRH).  Continuous, prolonged administration of goserelin in males results in inhibition of pituitary gonadotropin secretion, leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1228] "A drug used as treatment for hypercalcemia (abnormally high levels of calcium in the blood) and for cancer that has spread to the bone (bone metastases). It may decrease pain, the risk of fractures, and the development of new bone metastases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1229] "Sestamibi is a large synthetic molecule of the isonitrile family, which can be labeled with Tc99m.  It passes through cells membranes passively, collecting in cells with large numbers of mitochondria.  It is often used for imaging of the thyroid and parathyroid."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1230] "A drug used in photodynamic therapy. When absorbed by cancer cells and exposed to light, the drug becomes active and kills the cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1231] "Reactive intermediate oxygen species including both radicals and non-radicals. These substances are constantly formed in the human body and have been shown to kill bacteria and inactivate proteins, and have been implicated in a number of diseases. Scientific data exist that link the reactive oxygen species produced by inflammatory phagocytes to cancer development. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1232] "A synthetic radiopaque liquid form of perfluorooctyl bromide.  Used as a contrast agent for magnetic resonance imaging (MRI), perflubron is also used as a liquid ventilation agent to improve pulmonary gas exchange and lung compliance and may be used in surgery to reduce or eliminate the need for donor blood.  Ventilation with perfluorocarbon fluid improves lung function in conditions involving surfactant deficiency and dysfunction, including respiratory distress syndrome and adult respiratory distress syndrome. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1233] "An active form of cyclophosphamide. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1234] "A naturally-occurring phytochemical belonging to the class of isothiocyanates.  As the aglycone metabolite of glucosinolate glucoraphanin (sulforaphane glucosinolate), sulforaphane acts as an antioxidant and potent stimulator of endogenous detoxifying enzymes.  This agent displays anticarcinogenic properties due to its ability to induce phase II detoxification enzymes, such as glutathione S-transferase and quinone reductase, thereby providing protection against certain carcinogens and toxic, reactive oxygen species.  Broccoli sprouts contain large amounts of sulforaphane, which is also found in other cruciferous vegetables including cabbage and kale. (NCI04)"                                                                                                                                                                                                                                                                                                         
 [1235] "A moisturizing skincare formulation used for various skin conditions including dry skin conditions associated with eczema, psoriasis, chapped or chafed skin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1236] "A growth factor of the EGF family that induces growth and differentiation of epithelial, glial and muscle cells in culture.  It binds the receptor erbB3 which will heterodimerize with HER-2/erbB2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1237] "An inhibitor of aromatase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1238] "A drug that belongs to the family of drugs called nucleoside analogues. It is used to treat infection caused by viruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1239] "A substance that is being studied in the treatment of cancer. It belongs to the familyof drugs called somatostatin analogs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1240] "A diterpene taxane obtained from the bark and leaves of the yew tree (Taxus brevifolia) and can convert to taxol. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1241] "A substance that improves the body's natural response to infection and disease.  It is being studied as a topical agent (something used on the surface of the body) for the prevention of some types of cancer.  It belongs to the family of drugs called biological response modifiers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1242] "A diarylsulfonylurea compound that exhibits broad spectrum activity against several solid tumors including colon, ovary and lung cancers by an unknown mechanism. It has been dropped in phase II clinical trials mainly due to anemia and methemoglobinemia as well as poor effectiveness. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1243] "An anticancer drug that promotes differentiation by increasing the levels of retinoic acid within the tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1244] "An anticancer drug that belongs to the family of drugs called platinum compounds."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1245] "A drug that may increase the effectiveness of radiation therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1246] "A compound obtained from the needles of the Taxus baccata tree that is used as a precursor of paclitaxel. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1247] "A cell surface marker and differentiation antigen expressed on platelets and lymphocytes and released from them on activation. Activation of CD40 mediates B-cell proliferation, adhesion, and differentiation. Interactions between CD40 expressed on macrophages and CD40 ligand expressed on T lymphocytes can be an important signal for optimal macrophage activation. Mutation causes X-linked hyper-IgM syndrome (hypergammaglobulinemia). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1248] "A dioxolane nucleoside analog that is incorporated into the growing DNA chain of cancer cells, causing chain termination and interfering with DNA replication in the cancer cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1249] "A depsipeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity.  Less potent than the structurally-related compound dolastatin 10, dolastatin 15 binds weakly to tubulin and blocks microtubule assembly, thereby inhibiting mitosis.  Dolastatin 15 also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1250] "An anticancer drug that belongs to the family of drugs called differentiating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1251] "An anticancer drug that belongs to the family of drugs called alkylating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1252] "A semisynthetic derivative of the anthracycline antineoplastic antibiotic doxorubicin.  As an antineoplastic agent, morpholinodoxorubicin is more potent than doxorubicin.  Similar to doxorubicin, morpholinodoxorubicin intercalates into DNA and causes single- and double-strand breaks in DNA via inhibition of topoisomerase I and II.  Unlike doxorubicin, this agent is metabolized in vivo to a DNA-alkylating derivative that forms DNA interstrand cross-links, thereby potentiating its doxorubicin-like cytotoxicity. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1253] "Organochlorines are a group of compunds belonging to the chlorinated hydrocarbon pesticides (as aldrin, DDT, or dieldrin).  These compunds are believed to associated with many cancers, especially with breast cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1254] "A B-complex vitamin that is being studied as a cancer prevention agent. Also called folic acid."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1255] "The sodium salt form of hyaluronic acid, a glucosaminoglycan, a component of connective tissue, skin, vitreous humour, umbilical cord, synovial fluid and the capsule of certain microorganisms contributing to adhesion, elasticity, and viscosity of extracellular substances."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1256] "Drugs containing a radioactive substance that are used in the diagnosis and treatment of cancer and in pain management of bone metastases. Also called radioactive drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1257] "A procedure in which a liquid with barium in it is put into the rectum and colon by way of the anus.  Barium is a silver-white metallic compound that helps to show the image of the lower gastrointestinal tract on an x-ray."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1258] "The hydrochloride salt of the partial estrogen antagonist nafoxidine.  Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors.  This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue.  Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1259] "Thorium oxide (ThO2). A radiographic contrast agent that was used in the early 1930s through about 1954. High rates of mortality have been linked to its use and it has been shown to cause liver cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1261] "Term used to denote short DNA oligonucleotide chains used to prime DNA (and in some cases RNA) synthesis.  The polymerase begins template-directed nucleotide synthesis from the 3' end of the oligonucleotide primer, which is designed to bind to the template at a specific site according to its DNA sequence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1262] "A drug used to prevent blood clots.  It belongs to the family of drugs called anticoagulants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1263] "A drug that helps prevent the formation of blood clots; it belongs to the family of drugs called anticoagulants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1264] "Antibodies developed in the laboratory to recognize more than one protein on the surface of different cells. Examples include bispecific antibodies 2B1, 520C9xH22, mDX-H210, and MDX447."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1265] "A vaccine that consists of bacterial polysaccharide linked with a protein carrier. The protein carrier enhances the immune response in the host."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1266] "Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1267] "A cloning vector based upon elements of yeast chromosomes.  At a minimum these include: yeast telomeres, a yeast centromere, and a yeast autonomously replicating sequence (ARS).  Such vectors are propagated in yeast and then transferred into a target eukaryotic cell where the yeast sequences can be recognized and will maintain the molecule through cell division.  These vectors can maintain extremely large amounts of foreign DNA.  YACs are maintained as linear molecules"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1268] "A benzoyl-hydrazone derivative of the anthracycline antineoplastic antibiotic daunorubicin.  Zorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1269] "A recombinant therapeutic agent which is chemically identical to or similar to endogenous glial cell line-derived neurotrophic factor (GDNF).  GDNF is a glycosylated, disulfide-bonded homodimer distantly related member of the transforming growth factor-beta superfamily.  This agent is important in the development and maintenance of dopamine neurons, has restorative effects in a wide variety of rodent and primate models of Parkinson disease, and may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                   
 [1270] "[1-D-arabinofuranosyl-E-(2-bromovinyl)uracil]], a synthetic antimetabolite analogue of Thymidine with antiviral activity against varicella zoster virus, herpes simplex type 1 virus, and Epstein-Barr virus. Sorivudine triphosphate blocks viral DNA replication by inhibiting DNA polymerase activity, but it is not incorporated into elongating viral DNA. Potentially fatal in combination with 5'FU due to inhibition of dihydropyrmidine dehydrogenase by a sorivudine metabolite. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1271] "A drug used in cancer prevention that belongs to the family of plant drugs called monoterpenes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1272] "A macrocyclic antifungal antibiotic that inhibits signal-dependent transcriptional activation and induces differentiation in leukemia. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1273] "A butyrophenone that has been investigated for antineoplastic activity. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1274] "A drug that makes tumor cells more sensitive to radiation therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1275] "Dexniguldipine is the R-enantiomer of the dihydropyridine derivate niguldipine. Dexniguldipine showed a binding affinity to the P-glycoprotein and therefore it is to be assumed to block the P-glycoprotein pumping mechanism and to modulate multidrug resistance. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1276] "A recombinant agent which is chemically identical to or similar to endogenous fibroblast growth factor 3 (FGF-3). FGF-3 is a growth factor for epithelial cells, and is involved in the differentiation of mesodermal structures during embryonic development. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1277] "The recombinant form of endogenous MIP-1 beta chemokine that chemoattracts both neutrophils and monocytes, stimulates macrophages, and stimulates myelopoietic cell growth.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1278] "A drug that is being studied for its effectiveness in preventing graft-versus-host disease and autoimmune disorders."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1279] "A diagnostic imaging agent comprised of 111-Indium label, a chelator (DTPA) and a monoclonal murine antibody (MAb-B72.3) specific for a tumor-associated glycoprotein (TAG-72) frequently expressed by colorectal and ovarian carcinomas. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1280] "A guanine ribonucleotide derivative with immunomodulator effects."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1281] "A drug used to treat infection caused by viruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1282] "A synthetic cyclopropylpyrroloindole antineoplastic antibiotic.  Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis.  Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1283] "A recombinant soluble form of CD4 that binds to the envelope glycoprotein (gp110) of HIV and inhibits the binding of virus to CD4+ lymphocytes, resulting in an inhibition of virus infectivity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1284] "A colony-stimulating factor that stimulates the production of neutrophils (a type of white blood cell). It is a cytokine that belongs to the family of drugs called hematopoietic (blood-forming) agents. Also called granulocyte colony-stimulating factor (G-CSF)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1285] "A drug used in the treatment of chronic pain. Also called SNX 111."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1286] "A cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. Denileukin difitox directs the cytocidal action of diphtheria toxin to cells that express IL-2 receptors. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1287] "A recombinant, fusion protein derived from the coding sequences of two growth factors interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF).  PIXY-321 exhibits greater receptor binding affinity and colony stimulating activity than its parent cytokines.  This agent stimulates proliferation of immature hematopoietic cells and allows the stimulation and expansion of multi-lineage hematopoiesis from immature bone marrow progenitor cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1288] "A plant extract that may improve the ability of the immune system to respond to disease. It is being studied in combination with vaccine therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1289] "A vaccine based upon the ALVAC Canarypox virus vector."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1290] "An alkaloid phytochemical found in the Morinda Citrifolia (Noni) that inhibits the growth of RAS cancer cells. The exact mechanism is unknown but may involve the inhibition of tyrosine kinase. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1291] "A fixed combination of Amoxicillin and Clavulanic Acid, which inhibits beta-lactamase, a bacterial enzyme that inactivates amoxicillin. Current use: Extended Spectrum Antibiotic. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1292] "A drug that belongs to the family of drugs called angiogenesis inhibitors. It prevents the growth of new blood vessels into a solid tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1293] "A recombinant form of the endogenous Betacellulin, a member of the Epidermal Growth Factor family that is expressed primarily in the pancreas and induces differentiation of a pancreatic acinar cell line."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1294] "A member of the tyrphostin family of tyrosine kinase inhibitors that competitively binds and inhibits epidermal growth factor receptor and GTPase activity of transducin and induces apoptosis in human leukemic cell lines. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1295] "A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.  Rubritecant inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1296] "A 25-mer phosphorothioate oligonucleotide, targeting the gag gene in the human immunodeficiency virus (HIV-1).  Trials were suspended in 1997.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1297] "A compound that inhibits calmodulin kinase II and p60. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1298] "A water-insoluble camptothecin derivative.  Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages.  Because the terminal lactone ring of aminocamptothecin required for the agent's antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1299] "The recombinant analogue of an endogenous cytokine interleukin 13 with potential antineoplastic activity. Produced by lymphocytes and exhibiting a variety of functions, interleukin-13 (therapeutic) inhibits DNA synthesis and regulates inflammatory and immune responses. In animal models, this agent has been shown to kill tumor cells both directly and indirectly by activating the host immune system at the tumor site. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1300] "Anticancer drugs that inhibit cancer cell growth by stopping cell division. Also called antimitotic or antimicrotubule agents or mitotic inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1301] "A compound that selectively inhibits protein tyrosine kinase and nerve growth factor-dependent tyrosine phosphorylation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1302] "A colony-stimulating factor that stimulates the production of white blood cells, especially granulocytes and macrophages, and cells (in the bone marrow) that are precursors of platelets. It is a cytokine that belongs to the family of drugs called hematopoietic (blood-forming) agents. Also called granulocyte-macrophage colony-stimulating factor (GM-CSF)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1303] "A platinum compound used in chemotherapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1304] "A murine IgG monoclonal Fab fragment antibody labeled with technetium-99m directed against carcinoembryonic antigen (CEA), a protein that is overexpressed by many tumor cell types.  For tumors that overexpress CEA, arcitumomab may be used as an adjunct diagnostic imaging tool to obtain prognostic information following resection and to monitor for recurrent disease. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1305] "An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1306] "A bone-seeking chelating agent.  Has been used as a radiopharmaceutical in complexes with radioactive metals for bone marrow ablation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1307] "An anticancer drug that inhibits a hormone growth factor responsible for stimulating some cancer cells to multiply."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1308] "A laboratory-made colony-stimulating factor that stimulates the production of blood cells, especially platelets, during chemotherapy. It is a cytokine that belongs to the family of drugs called hematopoietic (blood-forming) agents. Also called interleukin-2 or IL-2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1309] "A fluoro-substituted analog of dideoxyadenosine that inhibits reverse transcriptase, thereby inhibiting telomerase activity and subsequent cell proliferation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1310] "An antibiotic drug used to treat infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1311] "A drug being studied in the treatment of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1312] "The parts of fruits and vegetables that cannot be digested. Also called bulk or roughage. Fiber may be effective in preventing cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1313] "A purine nucleoside component of DNA comprised of adenosine linked by its N9 nitrogen to the C1 carbon of deoxyribose.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1314] "A recombinant therapeutic agent which is chemically identical to or similar to endogenous epidermal growth factor (EGF).  As a mitogen, EGF stimulates the proliferation of epidermal, epithelial, and embryonic cells.  This agent is also a strong chemoattractant for fibroblasts and epithelial cells and is an important factor mediating angiogenesis and wound healing.  EGF and EGF-like factors have been shown to promote regeneration of the epidermis and the generation of granulation tissues following severe burns and, when locally administered, may improve healing of injured corneal tissues. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                         
 [1315] "Products in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, essential mineral, protein, herb, or similar nutritional substance. Nutritional supplements do not require FDA approval to be marketed. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1316] "A family of synthetic drugs used to treat moderate to severe pain.  They are similar to opiates such as morphine and codeine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1317] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1318] "Retrotransposons are transposable DNA elements (transposons) that employ retroviral-like reverse transcription during the process of transposition: retrotransposon DNA is first transcribed into an RNA template, then reverse transcribed into DNA, and then inserted into a new genomic site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1319] "agents which prevent excitotoxicity or other deleterious influences in the nervous system, either physiologically or when administered before or shortly after an insult."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1320] "Covalent adducts between chemical mutagens and DNA. Covalent adducts to DNA often constitute mutagenic compounds that activate DNA repair processes which, unless repaired prior to DNA replication, may induce nucleotide substitutions, insertions, deletions, or chromosomal rearrangements. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1321] "Radioimmunoconjugates, monoclonal antibodies conjugated to radioactive-emitting molecules. The advantage to using radioimmunoconjugates is that radiotherapy is targeted to the tumor cells, thereby limiting toxic effects on normal cells. Tumor eradication is accomplished by the antibody-mediated effects as well as by the cytotoxic activity of the radiation. Beta particles are tumoricidal over a distance of many adjacent cell diameters and achieve killing of antigen-negative tumor cells that would not be eliminated by the antibody alone. (From www.medscape.com)"                                                                                                                                                                                                                                                                                                                                                                                                              
 [1322] "Agents comprised of immune substances conjugated to diagnostic or therapeutic substances used for targeting of drugs and radioisotopes in Chemotherapy and Radioimmunotherapy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1323] "In chemistry, a substance that is similar, but not identical, to another."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1324] "An gent that has affinity for a receptor and intrinsic activity at that receptor.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1325] "A chloroethylnitrosourea derivative that inhibits proliferation and growth of tumor cells by alkylation and cross-linkage of DNA strands of tumor cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1326] "A drug that may protect healthy cells from chemotherapy and radiation without inhibiting the effects of these therapies on tumor cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1327] "An oligopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces distallicus.  Distamycin preferentially binds to adenine-thymine (A-T) rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and RNA transcription.  In addition to antitumor effects, distamycin also possesses antiviral and antiprotozoal activities and is used as a chromosome dye. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1328] "A drug that belongs to the family of drugs called selective estrogen receptor modulators (SERMs) and is used in the prevention of osteoporosis in postmenopausal women. Raloxifene is also being studied as a cancer prevention drug."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1329] "A quinoline-3-carboxamide with potential antineoplastic activity.  Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion, reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs) and inhibits angiogenesis.  This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1330] "An anthrapyrazole antineoplastic antibiotic.  Teloxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair, as well as RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1331] "An anticancer drug that belongs to the family of drugs called antipyrazoles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1332] "A drug used in diabetes treatment that is being studied for its effect on reducing the risk of cancer cell growth in fat tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1333] "A heptapeptide synthetic somatostatin octapeptide analog that binds preferentially to pituitary somatostin receptors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1334] "An orally-active fumarate salt of liarozole, an agent with potential antineoplastic.  As a retinoic acid metabolism blocking agent (RAMBA), liarozole fumarate inhibits cytochrome P450 dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation.  This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1335] "A 5-hydroxytryptamine-3 (5-HT3) antagonist with antiemetic activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1336] "A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata.  Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death.  This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response.  Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04)"                                                                                                                                                                                                                                                                                                                                                  
 [1337] "A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure.  As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis.  In estrogen-dependent breast cancers, ananstrozole may inhibit tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1338] "(ris-ED-roe-nate) A substance that is being studied in the prevention and treatment of osteoporosis. It belongs to the family of drugs called bone resorption inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1339] "A synthetic hydroxamate with potential antineoplastic activity.  Batimastat binds covalently to the zinc ion in the active site of matrix metalloproteinases (MMPs), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1340] "A combination of drugs used to fight infections in people who have cancer. Piperacillin is a synthetic penicillin; tazobactam enhances the effectiveness of piperacillin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1341] "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous chemokine eotaxin, a member of the C-C cytokine family which is chemotactic for eosinophils.  CD4+ T cells which secrete eotaxin may induce regression of tumor metastases.  This effect of eotaxin, in combination with its chemoattractant properties, indicates a potential role for eotaxin in cancer immunotherapy. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1342] "A quassinoid agent extracted from the bark of Simaba guianensis and has shown antimalarial activity in vitro. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1343] "A synthetic pyrimidine-based antifolate. Pemetrexed inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.  Pemetrexed has been demonstrated to have activity against colon cancer, mesothelioma and nonsmall-cell lung cancer. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1344] "An amino acid analog tracer for positron emission tomography (PET) imaging used to locate and differentiate tumors, and as a means of monitoring the therapeutic effect of tumor irradiation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1345] "A quassinoid phytochemical isolated form the plant Brucea antidysenterica with potential antineoplastic activity.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1346] "A quassinoid phytochemical isolated from the plant Brucea antidysenterica with potential antineoplastic activity.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1347] "A quassinoid phytochemical isolated from the plant Brucea antidysenterica with potential antineoplastic activity.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1348] "A recombinant agent, which is chemically identical to or similar to the endogenous protein Fas ligand, a protein related to tumor necrosis factor (TNF) with potential antineoplastic activity.  Fas ligand binds to the Fas receptor, thereby activating caspases and inducing apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1349] "A drug that belongs to a family of drugs called ribonucleotide reductase inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1350] "A protein tyrosine kinase inhibitor that selectively inhibits EGFR kinase, involved in signaling pathways. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1351] "A 24 base pair phosphorothioate oligonucleotide targeting codons 2-9 of the c-MYB gene, resulting in suppression of c-MYB protein expression and has been in clinical trials for leukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1352] "A semisynthetic anticancer drug that belongs to the family of drugs called antitumor antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1353] "A protein that causes white blood cells to recognize and destroy melanoma cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1354] "A bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum.  Depsipeptide inhibits histone deacetylase affecting the regulation of gene expression and inducing cell differentiation, cell cycle arrest, and apoptosis.  This agent also inhibits hypoxia-induced angiogenesis and depletes several HSP90-dependent oncoproteins.  Depsipeptide has been studied as a potential antineoplastic agent. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1355] "Cytokine IL15 affects T-lymphocyte activation and stimulates T-cell proliferation, similar to IL2.  CD8+ memory T-cells divide slowly, requiring IL15, and markedly increase with inhibition of IL2.  The numbers of CD8+ memory T-cells may be controlled by a balance between IL15 and IL2.  IL15 may use components of the IL2R, which contains at least three subunits: alpha, beta, and gamma.  IL15 can also induce B-lymphocyte proliferation and differentiation.  IL15 is transcribed in a variety of cell types including fibroblasts, epithelial cells, and monocytes, but not primary T cells.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                  
 [1356] "The cryptophycins are a family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. The mechanism of anticancer activity of the cryptophycins has been associated with their destabilization of microtubules and induction of bcl-2 phosphorylation leading to apoptosis. Cryptophycins demonstrated activity against the wide spectrum of solid tumors including those that overexpress the multidrug resistance efflux pump P-glycoprotein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1357] "A protein tyrosine kinase inhibitor that has specific activity for the epidermal growth factor receptor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1358] "A recombinant agent, which is chemically identical to or similar to the endogenous protein Fas ligand OX40, a member of the tumor necrosis factor (TNF) family.  Expressed by antigen presenting cells (APC), OX40 ligand binds to the OX40 receptor on CD4 T-cells, thereby priming antigen-specific activation of CD4 T-cells and inducing CD4 T-cell secretion of interleukin 4 (IL-4). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1359] "An immunotoxin consisting of an anti-Lewis Y antigen antibody linked to a 40kD fragment of Pseudomonas exotoxin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1360] "A vitamin that is soluble in fat solvents and oils (lipo-soluble). Fat-soluble vitamins include vitamins A, D, E, K, F. Absorbed with ingested dietary fat, fat-soluble vitamins are stored in moderate amounts from the gastrointestinal tract. Present in minute amounts in various foods, these vitamins are essential to maintaining normal metabolism and biochemical functions; fat malabsorption may result in fat-soluble vitamin deficiencies. Fat-soluble vitamins are found in many types of foods and may be supplemented with pharmaceutical formulations. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1361] "Vitamins that are freely soluble in water."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1362] "An oil based formulation of Vasopressin, which could be administered intramuscularly. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1363] "Compounds that influence the function of the thyroid hormone through replacement, inhibition or stimulation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1364] "A murine monoclonal IgG2a antibody to tumor-associated epithelial cell adhesion molecule (EpCAM, or 17-1A) antigen. Edrecolomab attaches to EpCAM, a human cell surface glycoprotein that is found on normal epithelial cells and some tumor cells, such as those of colon and breast carcinomas. Upon binding, this agent recruits the body's immune effector cells, which may exhibit antitumor cytotoxicity. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1365] "A liposome-encapsulated form of the hydrochloride salt of the anthracycline antineoplastic antibiotic doxorubicin.  Liposomal delivery of doxorubicin HCL improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects.  Doxorubicin intercalates into DNA and interacts with topoisomerase II, consequently inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                        
 [1366] "Class of drugs that affect the metabolism and utilization of purines."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1367] "Class of drugs that affect the metabolism and utilization of pyrimidines."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1368] "A group of penicillins with extended gram-negative bacterial coverage, including Ticarcillin, Piperacillin, Carbecillin, Timentin and Mezlocillin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1369] "A folic acid derivative that allows for the synthesis of purine and thymidine involved in normal erythropoiesis. It provides the necessary cofactor blocked by methotrexate and decreases the associated bone marrow and gastro-intestinal toxicities. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1370] "An inhibitor of the intracellular enzyme dihydroorotate dehydrogenase, required for de novo synthesis of pyrimidines, causing inhibition of DNA synthesis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1371] "A monoclonal antibody generated by fusing the variable region genes of murine Lym-1 to human gamma-1 and kappa constant regions. Current use: developing immune-interventions in B-lymphomas. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1372] "A beta particle-emitting radiopharmaceutical.  It localizes in metastatic foci in bone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1373] "The R-enantiomer of the calcium channel blocker verapamil. Dexverapimil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms.  This agent exhibits decreased calcium antagonistic activity and toxicity compared to racemic verapamil. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1374] "A DNA intercalating agent.  Can inhibit both topoisomerases I and II."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1375] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1376] "Consists of Amphotericin B complexed with dymyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol, formulated to provide lower toxicity with efficacy similar to the parent compound, Amphotericin B. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1377] "A radioactive compound that is absorbed by the bone. It is used to treat bone pain associated with prostate cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1378] "A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), dihydrosphingosinet competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis.  This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1379] "A monoclonal antibody that is being studied for treatment of adult T-cell leukemia.  Also called dacliximab.  Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1380] "A chimeric anti-GD2 monoclonal antibody that, comprised of the variable region of the parent murine monoclonal antibody directed at the disialoganglioside antigen GD2, a ganglioside overexpressed on neuroblastoma cells, and the human gamma-1 and kappa constant regions. It binds to cancer cells and causes tumor cell death. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1381] "A small molecule inhibitor of cyclin-dependent kinase.  It shows clinical promise as an anti-cancer agent and as a immunosuppressive agent due to its ability to inhibit cell division."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1382] "A vaccine produced from genetically engineered viral vector by introduction of foreign genetic materials to activate immune response in a host."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1383] "A drug used in vaccine therapy to stimulate the immune system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1384] "A drug being studied for cancer prevention.  It belongs to the family of drugs called retinoids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1385] "A lipophilic disaccharide tripeptide derivative of muramyl dipeptide (MDP).  Exhibiting greater immunomodulatory effects than MDP, disaccharide tripeptide glycerol dipalmitoyl, when encased in liposomes, stimulates macrophage activity and increases serum levels of tumor necrosis factor alpha (TNF alpha), neopterin, interleukin (IL)-1 alpha, IL-1 beta, IL-6, IL-8, and IL-12, thereby activating host immune system antitumor functions.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1386] "A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called DNA-intercalating compounds. Also called CI-958."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1387] "A water-soluble lipophilic folate-based agent designed to interact with the folate binding site of Thymidylate Synthase, inhibiting de novo synthesis of thymidine and causing inhibition of DNA synthesis.  Nolatrexed has been in clinical trials for hepatocellular cancer and solid tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1388] "A partially humanized bispecific antibody containing Fab fragments of a monoclonal antibody (520C9) targeting HER2/neu-expressing tumor cells and a monoclonal antibody (H22) targeting Fc gamma RI (CD64) receptor-expressing effector cells.  Bispecific Antibody 520C9xH22 (MDX-H210) has been in clinical trials for metastatic cancers, breast and ovarian cancers that overexpress HER2/neu antigen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1389] "Eflornithine is a proven cure of human African trypanosomiasis. It is also used as a prescribed cream, under the trade name Vaniqa, to treat unwanted facial hair in women."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1390] "One of a number of antinuclear autoantibodies.  Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1391] "1-Benzyl-3-(3-dimethylamino)propoxy)-1H-indazole monohydrochloride. An analgesic, antipyretic, and anti-inflammatory agent used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of rhe"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1392] "Hydrochloride salt of the anthracycline antineoplastic antibiotic carubicin.  Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1393] "An anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces coeruleorubidus.  Daunomycin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1394] "An antidiarrheal drug."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1395] "(LOO-brih-kants) Oily or slippery substances."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1396] "A substance used to treat bacterial infections.  It belongs to the family of drugs called quinolone antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1397] "The hydrochloride salt of the anthracycline antineoplastic antibiotic idarubicin.  Idarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.  Due to its high lipophilicity, idarubicin HCL penetrates cell membranes better than other anthracycline antibiotics. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1398] "The injection salt form of Ganciclovir. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1399] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1400] "Antineoplastic agents that are highly reactive chemicals and have the ability to introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1401] "Formulated therapeutic analogs of one of a number of endogenous chemotactic polypeptide cytokines.  Beta chemokine is synthesized and released by macrophages, endothelial cells, keratinocytes, fibroblasts, and smooth muscle cells in response to infection or tissue damage, recruiting circulating macrophages to sites of production.  This agent may regulate tumor growth by modulating tumor-associated angiogenesis and metastasis and may either promote or inhibit tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1402] "One of a number of chemotactic cytokines. Alpha chemokines are small polypeptides released by macrophages, endothelial cells, keratinocytes, fibroblasts, and smooth muscle cells in the presence of infection or physical tissue damage.  In a therapeutic setting, these agents may act as chemoattractants to recruit neutrophils and T cells from the blood to sites of infection or damage and may either promote or inhibit tumor growth by modulating tumor-associated angiogenesis and metastasis. Also known as CXC chemokines. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1403] "Formulated therapeutic analogs of one of a number of endogenous small polypeptide cytokines with potential antineoplastic activity. Synthesized by macrophages, endothelial cells, keratinocytes, fibroblasts, and smooth muscle cells, chemokines are released in the presence of infection or physical tissue damage, and act as chemoattractants to recruit macrophages, neutrophils, and T cells from the blood to sites of infection or damage.  These agents may regulate tumor growth by modulating tumor-associated angiogenesis and metastasis and can either promote or retard tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                     
 [1404] "A member of a family of anticancer drugs that are also antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1405] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1406] "An antiangiogenic polysaccharide toxin derived from group B streptococcus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1407] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1408] "A derivative of the antitumor antibiotic spergualin with immunosuppressant activity.  Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1409] "A synthetic, nonsteroidal antiandrogen.  Bicalutamide competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens. This agent does not bind to most mutated forms of androgen receptors. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1410] "1(3-hydroxy-2-phosphonomethoxypropyl) cytosine; potent selective inhibitor of human cytomegalovirus replication; used in CMV retinitis therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1411] "A hormone therapy drug used to decrease the production of estrogen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1412] "A drug that belongs to the family of drugs called protease inhibitors. It interferes with the ability of a virus to make copies of itself."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1413] "N-deformyl-N-(4-N-N,N-bis(2-choroethylamino)benzoyl)distamycin, a nitrogen mustard compound with alkylating antineoplastic activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1414] "A cationic cholesterol derivative mixed with dimethylaminoethane-carbamoyl and sonicated to form small unilamellar vesicles that can complex with DNA, DNA/protein complexes and other drug complexes and mediates the delivery into the cytosol from the endosome compartment. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1415] "A sulfated polysaccharide isolated from various Arthrobacter bacterial species.  Possessing potential antiangiogenic and antineoplastic properties, tecogalan binds to basic fibroblast growth factor (bFGF), thereby preventing bFGF from binding to its receptors.  Disruption of this receptor binding results in the inhibition of bFGF-stimulated endothelial cell growth, proliferation, and migration. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1416] "A substance that is being studied for its ability to help other drugs reach the brain.  It belongs to the family of drugs called bradykinin agonists. Also called lobradimil."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1417] "A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure.  As a third-generation aromatase inhibitor, anastrozole selectively and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis.  In estrogen-dependent breast cancers, ananstrozole may inhibit tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1418] "Lymphotoxin is a cytokine that orchestrates lymphoid neogenesis and is present on the surface of activated T-, B-, and LAK cells as a heterotrimer of alpha and beta subunits. It is also secreted as an alpha homotrimer. LT beta glycoprotein is a 33 kD type II membrane protein that anchors LT alpha to the cell surface."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1419] "A drug that belongs to the family of drugs called protease inhibitors. It interferes with the ability of a virus to make copies of itself."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1420] "A semisynthetic analogue of camptothecin that inhibits topoisomerase I, causing a single strand breakage of the DNA and cell death. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1421] "A semisynthetic analogue of the tetracyclic antibiotic quinocarmycin.  7-Cyanoquinocarcinol belongs to the naphthyridinomycin/saframycin class of antitumor antibiotics.  These antibiotics appear to exert their effects through DNA alkylation.  It was tested for possible use in patients with refractory solid malignancies, but was abandoned due to its causing renal and gastrointestinal toxicities in an unpredictable manner. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1422] "An anticancer drug that belongs to the family of drugs called alkylating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1423] "A 4:1 mixture of phenylacetate and phenylacetylgluatmine, degradation products of the antineoplaston agent A10.  Antineoplaston AS2-1 inhibits the incorporation of L-glutamine into tumor-cell proteins, leading to cell cycle arrest in the G1 phase and inhibition of mitosis.  This agent may also inhibit RAS oncogene expression and activate tumor suppressor gene p53, resulting in cell differentiation and apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1424] "A semisynthetic derivative of the nucleoside-like antineoplastic antibiotic spicamycin, originally isolated from the bacterium Streptomyces alanosinicus.  KRN 5500 inhibits protein synthesis by interfering with endoplasmic reticulum and Golgi apparatus functions.  This agent also induces cell differentiation and caspase-dependent apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1425] "A bisnaphthalimide that intercalates DNA, causing inhibition of DNA, RNA, and protein synthesis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1426] "A weak tyrosine kinase inhibitor which has been used as a negative control analogue for Lavendustin A. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1427] "An antibody-drug conjugate composed of the chimeric monoclonal antibody BR96 chemically linked to the cytotoxic drug doxorubicin that binds to a cell surface Lewis-related antigen expressed on many solid tumor types.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1428] "The BAGE gene family encodes CT antigens, recognized by cytotoxic T-lymphocytes.  BAGE is expressed in normal adult testis and in some melanomas, infiltrating bladder carcinomas, mammary carcinomas, head and neck squamous cell carcinomas, and non-small cell lung carcinomas.  The function of BAGE protein is unknown.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1429] "A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin attaches to B3, a Lewis Y-related carbohydrate epitope on some solid tumor cells.  The antibody attaches to the cell and the exotoxin inhibits protein synthesis by inactivating elongation factor 2. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1430] "A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin.  The rebeccamycin analogue intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis.  (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1431] "A drug containing a radioactive isotope that is used in the diagnosis and treatment of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1432] "An extract from the myxobacteria Sorangium cellulosum that promotes tubulin polymerization and microtubule stabilization, causing tumor cell death. Epothilone A appears to be less potent than Epothilone B. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1433] "A compound isolated from the myxobacterium Sorangium cellulosum.  Similar to paclitaxel, epothilone B induces microtubule polymerization and stabilizes microtubules against depolymerization conditions.  In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes.  Epothilone B may cause complete cell-cycle arrest. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1434] "A drug that interferes with the ability of a virus to make copies of itself."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1435] "A cell-permeable, selective mitogen-activated protein (MAP) kinase inhibitor which exhibits activity through the inhibition of the phosphorylation and activation of MAP kinase. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1436] "A substance that inhibits Leukotriene b4 receptor and causes anti-proliferation and induces apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1437] "A carbohydrate molecule expressed on the surface of solid tumors including lung, intestinal, breast, prostate, pancreatic, esophageal, stomach, colon, rectal or ovarian cancers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1438] "A quassinoid phytochemical isolated from Castela polyandra and other plant species with potential antineoplastic activity.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1439] "An orally available nonpolyglutamated, quinazoline antifolate which selectively inhibits Thymidylate Synthase, inhibiting de novo synthesis of thymidine and causing inhibition of DNA synthesis.  ZD9331 has been in clinical trials for ovarian epithelial, primary peritoneal or fallopian tube cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1440] "Interleukin 14 is a cytokine produced by T-cells that induces B-cell proliferation, maturation, and differentiation, inhibits Ig secretion, and selectively expands certain B-cell subpopulations.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1441] "A recombinant therapeutic agent which is chemically identical to or similar to an endogenous glycoprotein which inhibits pituitary production of follicle-stimulating hormone (FSH).  Produced and secreted by the testis or ovarian follicle, endogenous inhibin A contributes to the control of gametogenesis, embryonic and fetal development, and hematopoiesis and enhances LH-stimulated androgen secretion by human thecal cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1442] "A substance that is being studied as an anticancer drug.  It belongs to the family of drugs called diarylsulfonylureas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1443] "A polyvalent vaccine that induces an immunological response against more than one type of melanoma. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1444] "A synthetic dolastatin 15 analogue with potential antineoplastic activity.  Cemadotin suppresses spindle microtubule dynamics by binding to tubulin, thereby blocking mitosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1445] "A synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties.  Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1446] "Synthetically made hormones possessing the steroid ring system; e.g., androgens, estrogens, and adrenocortical hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1447] "A substance that inhibits xanthine oxidase, a potential source of excess oxygen free-radical production and is involved in the metabolic pathway for uric acid formation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1448] "An unstable isotope of carbon created when a neutron collides with a nitrogen atom, causing capture of the neutron and release of the proton converting nitrogen to a carbon with fourteen nucleons (6 protons and 8 neutrons).  Carbon-14 emits beta particles as it decays and reverts back to nitrogen.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1449] "A radioactive isotope of iodine that emits beta and gamma particles with a half-life of eight days used for the treatment of various thyroid conditions and in Radioimmunotherapy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1450] "A radioisotope with a physical half-life of 2.83 days, used to label agents for diagnosis, disease progression and treatment. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1451] "Radioactive isotope of yttrium.  A beta/gamma-emitter with a half life of 2.7 days."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1452] "One of the radioactive isotopes of technetium, a gamma/beta-emitter with a half life of 6 hours."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1453] "A mixture of sterile polysaccharide capsular antigens from several differing serotypes of Streptococcus pneumoniae. Pneumococcal vaccine is a polyvalent active immunizing agent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1454] "A bacterium that may stimulate the immune system to fight cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1455] "A colorless volatile poisonous liquid compound used as a solvent, fuel, aerosol, propellant and refrigerant. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1456] "A hematopoietic growth factor with activity on mature and immature hematopoietic progenitor cells. Current use: development of treatment for sickle cell anemia, acquired aplastic anemia, protect against lethal irradiation, and elicit multilineage hematopoietic responses. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1457] "A humanized recombinant monoclonal antibody directed against the HER2- receptor protein.  Trastuzumab binds to the extracellular domain of the growth factor protein HER2, thereby inhibiting proliferation of HER2 overexpressing tumor cells.  Binding with HER2 protein also initiates an antibody-dependent cell cytotoxicity.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1458] "A cancer vaccine containing a canary pox virus (ALVAC) combined with the human carcinoembryonic antigen (CEA) gene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1459] "A substance that is being studied as a gene therapy agent for the treatment of cancer.  It increases the ability of the immune system to recognize cancer cells and kill them."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1460] "A substance that is being studied for the treatment of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1461] "A substance that is being studied in photodynamic therapy.  It belongs to the family of drugs called metallotexaphyrins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1462] "An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Marimastat is a matrix metalloproteinase inhibitor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1463] "A drug being studied to make cancer cells less resistant to the effects of chemotherapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1464] "A dietary supplement containing all or most of the vitamins that may not be readily available in the diet. Vitamins may be classified according to their solubility either in lipids (vitamins A, D, E, K, F) or in water (vitamins C, B- complex). Present in minute amounts in various foods, vitamins are essential to maintaining normal metabolism and biochemical functions. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1465] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1466] "A radioisotope with an atomic number of 75 and a half life of 90 hours that emits beta particles and gamma rays and is used in cancer treatment and diagnostic imaging technique. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1467] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1468] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1469] "A progestogen-like compound used as a cattle feed additive for its growth promoting effects and suppression of estrus (heat) in heifers. Critics have claimed that hormones used as growth promotants in cattle may cause breast cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1470] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1471] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1472] "A drug that interferes with the ability of a virus to make copies of itself."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1473] "A vaccine designed to prevent or treat cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1474] "Produced by macrophages, endothelial cells, and keratinocytes in response to IFN-gamma.  Based on experiments using recombinant human IP-10, this protein is a moderately potent in vitro chemoattractant of human monocytes but not neutrophils and is probably a participant in chronic cell-mediated inflammatory reactions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1475] "An epoxide-containing cyclotetrapeptide with antitumor activity.  It is an irreversible inhibitor of histone deacetylase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1476] "A potent protein tyrosine kinase inhibitor that exhibits greater specificity for c-ErbB oncoprotein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1477] "A non-phenolic tyrphostin-class tyrosine kinase inhibitor that inhibits epidermal growth factor receptor, affecting cell proliferation and tumor growth in vivo. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1478] "The recombinant analog of endogenous beta (B) chain of the cytokine platelet-derived growth factor (PDGF).  Synthesized primarily by megakaryocytes, endogenous PDGF consists of two related peptide chains, PDGF-A and PDGF-B.  PDGF functions as a local autocrine and paracrine growth factor in many cellular processes.  Recombinant PDGF, alone and in combination with other agents, may be useful in promoting bone formation and soft tissue repair. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1479] "An anticancer drug that is also used in cancer prevention. It belongs to the family of drugs called photosensitizing agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1480] "A biphosphonate used for treatment of osteoporosis.  It has 10,000x the bone resorption blocking activity of etidronate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1481] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1482] "An anticancer drug belonging to a family of drugs called radiopharmaceuticals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1483] "An anticancer drug that may inhibit the growth of some tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1484] "A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 2 (FGF-2).  Reflecting its endogenous role, therapeutic FGF-2 exhibits a wide spectrum of biological activities, including the promotion of growth and differentiation in target cells, the regulation of hormone secretion, and the promotion of angiogenesis.  This agent's mitogenic effects on fibroblasts and endothelial cells indicates a potential role in therapeutic angiogenesis and wound healing.  In addition, therapeutic FGF-2 may stimulate neurogenesis and protect neurons against degeneration; FGF-2 supplementation via gene transfer may reduce neuronal degeneration in experimental animal models. (NCI04)"                                                                                                                                                                                                                                             
 [1485] "A potent inhibitor of epidermal growth factor receptor kinase autophosphorylation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1486] "The B isomer of Curacin compound. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1487] "The C isomer of Curacin compound. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1488] "The A isomer of Curacin compound. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1489] "A derivative of camptothecin, a topoisomerase I inhibitor"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1490] "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-18 (IL-18). Produced primarily by macrophages, IL-18 induces the production of interferon-gamma (IFN-gamma), and enhances the activity of natural killer (NK) and cytotoxic T lymphocytes (CTL).  As a potential immunotherapeutic agent, IL-18 displays antitumor effects in vitro and in animal models. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1491] "A monoclonal antibody used to treat leukemia. Monoclonal antibodies are made in the laboratory. They can find cancer cells and bind to them.  Also called Campath-1H."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1492] "A farnesyl transferase inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1493] "A member of the tyrphostin family of tyrosine kinase inhibitors that inhibits epidermal growth factor receptor, capacitative calcium ion entry into cells, blocks HT-29 colon cancer cell proliferation and induces non-apoptotic cell death. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1494] "Interleukin 17 is a homodimeric pro-inflammatory cytokine expressed in stimulated, but not resting, cytotoxic T-cells or their precursors that induces stromal cells to produce pro-inflammatory and hematopoietic cytokines.  IL17 enhances expression of IL6, IL8, and ICAM-1 in fibroblasts and appears to induce osteoclastogenesis and ODF, a membrane-associated protein essential to osteoclast differentiation.  IL17 has sequence similarity to the herpesvirus saimiri immediate early gene 13 protein.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1495] "CMAP Definition: Apoptosis inducing ligand 2 (also called TRAIL); member of TNF family; Decoy receptors may cause resistance to APO2L"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1496] "A phenol mustard glutamate prodrug which induces apoptosis by cross-linking DNA and with potential use in Antibody Directed Enzyme Prodrug Therapy (ADEPT). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1497] "A drug that is being studied for its ability to inhibit the growth of certain cancers. It interferes with a portion of the protein produced by the bcr/abl oncogene.  Also called Gleevec and STI571."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1498] "A member of the tyrphostin family of tyrosine kinase inhibitors, which selectively inhibits HER2. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1499] "A cyclic depsipeptide isolated from the marine tunicate Aplidium albicans.  Aplidine displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation.  This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1500] "A vaccine composed of a substance that enhances immunity plus an antigen found on some tumors of the colon, breast, lung, ovary, pancreas, and stomach."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1501] "A tetrahydroisoquinoline alkaloid isolated from the marine tunicate Ecteinascidia turbinate.  Ecteinasciidin 743 (ET743) exhibits potent tumor cytotoxicity by prolonging the G2-M phase of the cell cycle.  This agent interacts with the transcription-coupled nucleotide excision repair machinery to induce lethal DNA strand breaks. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1502] "A vaccine comprised of a fragment of the gastrointestinal growth factor-17 (G-17) linked to diphtheria toxin to block gastrin and elicit an immune response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1503] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1504] "A natural quassinoid agent extracted from Brucea antidysenterica with potential antineoplastic activity that is cytotoxic to certain cancer cell lines. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1505] "A quassinoid phytochemical isolated from the plant Brucea antidysenterica with potential antineoplastic activity.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1506] "An inhibitor of histone deacetylase.  It is an aromatic sulfonamide hydroxamate initially found in a screen for inhibitors of the tumorigenic phenotype of K-ras-transformed NIH3T3 cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1507] "Any substance or physical agent that inhibits development and kills fungus spores and mycelium. In the United States, fungicides are governed by the 1972 federal Environmental Protection and Control Act. They must be registered with the Environmental Protection Agency and must conform to specifications. They must control the disease without injuring the plant and must leave no poisonous residue on edible crops. Antifungal drugs are approved by the FDA. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1508] "A radioactive form of phosphorus used in the treatment of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1509] "A drug that belongs to the family of drugs called bisphosphonates. It is used to prevent bone fractures and reduce bone pain in people who have cancer that has spread to the bone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1510] "A drug that belongs to the family of anticancer drugs called taxanes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1511] "A cancer vaccine containing the carcinoembryonic antigen (CEA) gene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1512] "A chimeric anti-CD20 antibody consisting of human IgG1-kappa constant regions and variable regions from the murine monoclonal anti-CD20 antibody IDEC-2B8 (IDEC Pharmaceuticals Corporation)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1513] "An anticancer drug that inhibits the transformation of normal cells to cancer cells. It belongs to the family of drugs called enzyme inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1514] "An anticancer drug that belongs to the family of drugs called antimetabolites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1515] "A biphenyl matrix metalloproteinase (MMP) inhibitor with potential antineoplastic activity.  Tanomastat inhibits MMP-2, MMP-3, and MMP-9, thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1516] "A disaccharide analogue of the anthracycline antineoplastic antibiotic doxorubicin.  MEN-10755 intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also induces apoptosis through a p53-independent mechanism.  MEN-10755 is less cardiotoxic than doxorubicin. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1517] "A drug that treats infections caused by fungi."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1518] "A natural, synthetic or semisynthetic substance that has specific characteristics. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1519] "RAEB-2: Particulates (Carcinogens): Minute solids, such as powders or fibers, that may be carcinogenic when inhaled."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1520] "A drug that protects healthy tissues from the toxic effects of anticancer drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1522] "A family of synthetic or recombinant C-type chemokines lacking adjacent cysteine residues and act as chemoattractants for lymphocytes.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1523] "A member of the tyrphostin family of tyrosine kinase inhibitors, that actively blocks lipopolysaccharide-induced production of tumor necrosis factor-a and nitric oxide in macrophages. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1524] "A drug that increases the number of immune cells and may stimulate the immune system to kill cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1525] "A member of the tyrphostin family of tyrosine kinase inhibitors, that selectively inhibits epidermal growth factor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1526] "A humanized mouse recombinant monoclonal antibody that is grafted to a complementarity-determining region. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1527] "A semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens. Irofulven alkylates macromolecules (DNA and protein), forms adducts, and arrests cells in the S-phase of the cell cycle.  This agent requires NADPH-dependent metabolism by alkenal/one oxidoreductase for activity. Irofulven is more active in vitro against tumor cells of epithelial origin and is more resistant to deactivation by p53 loss and MDR1, among other mechanisms, than other alkylating agents. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1528] "An ureido-derivative of pyridine that induces differentiation in neoplastic cells, causing inhibition of cell proliferation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1529] "A synthetic compound with polyethylene glycol conjugated with recombinant megakaryocyte growth and development factor.  It was used for the normalization of platelet production in HIV-infected persons."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1530] "A drug being studied in the treatment of cancer. It is a biological response modifier that belongs to the family of drugs called glycosphingolipids or agelasphins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1531] "A member of the tyrphostin family of tyrosine kinase inhibitors that selectively inhibits human p210 tyrosine kinase activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1533] "A monoclonal antibody specific for the epidermal growth factor receptor (EGFR), a tyrosine kinase that triggers cell division.  Cetuximab binds to and inhibits EGFRs, which are overexpressed on the cell surfaces of many types of tumors.  This agent blocks the tumor growth, invasion, and metastasis associated with the overexpression of cell-surface EGFRs. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1534] "A drug used to prevent or treat infections caused by a fungus (a type of microorganism).  It belongs to the family of drugs called antifungal agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1535] "A substance that inhibits the tyrosine kinase activity of the fibroblast growth factor receptor 1 through the signalling pathway. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1536] "A substance that inhibits the tyrosine kinase activity of fibroblast growth factor receptor 1, tyrosine phosphorylation of the PDGF receptor and the insulin receptor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1537] "An anticancer drug that belongs to the family of drugs called alkylphospholipids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1538] "A drug that reduces pain. Celecoxib belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is being studied for cancer prevention."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1539] "1-(11-dodecylamino-10-hydroxyundecyl)-3,7-dimethylxanthine.  cytotoxic to some tumor cells in vitro.  may have an antiangiogenesis activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1540] "714-X is a product elaborated and marketed by the private Canadian laboratory. Was found to contain nitrogenated camphor-derivative trimethylbicyclonitraminoheptane chloride, mineral salts, ethyl alcohol, and water. It is claimed to cure cancer, multiple sclerosis, fibromyalgia, AIDS and other diseases by improving the body's immune function. Few inconclusive animal studies and no human trials were conducted with the product. There is no scientific evidence that 714-X is effective in treating any type of disease. It has not been proven to be safe or effective for any use. 714-X is banned by FDA for use in the USA. In Canada 714-X is legally available on compassionate grounds only through a licensed physician. (NCI)"                                                                                                                                                                                                                                               
 [1541] "A member of the tyrphostin family of tyrosine kinase inhibitors that selectively inhibits platelet-derived growth factor receptor protein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1542] "An immunotoxin consisting of an anti-CD40 antibody linked to a 40kD fragment of Pseudomonas exotoxin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1543] "A quinoline derivative that inhibits both topoisomerase I and II, causing a cytotoxic effect in cancer cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1544] "A drug being studied for its ability to enhance the effectiveness of IL-2 in treating acute myeloid leukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1545] "Sodium salt of methotrexate, an inhibitor of dihydrofolate reductase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1546] "A member of the vitamin B complex, involved in several fundamental biological processes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1547] "A group of organic liquid compounds that are used for extracting, dissolving, or suspending other water insoluble compounds. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1548] "Amphotericin B encapsulated in liposomes and has decreased side effects of conventional Amphotericin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1549] "The sulfate salt form of vincristine, a vinca alkaloid which reversibly inhibits mitosis by binding to microtubule protein, tubulin, ultimately inhibiting formation of mitotic spindle.. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1550] "An agent that blocks the function of the enzyme aromatase with antineoplastic activity.  Aromatase inhibitors belong to two classes: Type I steroidal drugs are androgen substrate analogues that bind competitively but irreversibly to the enzyme.  Type II nonsteroidal inhibitors fit into the substrate binding site and bind reversibly to the enzyme.  Present in many tissues, aromatases are heme-containing enzymes that catalyze the adrenal conversion of cholesterol to pregnenolone and the peripheral conversion (aromatization) of androgenic precursors to estrogens. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                     
 [1551] "A chlorine anion that forms the negatively charged part of certain salts, including sodium and hydrogen chloride salts, and is an essential electrolyte located in all body fluids responsible for maintaining acid/base balance, transmitting nerve impulses and regulating fluid in and out of cells.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1552] "A substance that may prevent the formation of blood vessels. In anticancer therapy, an angiogenesis inhibitor prevents the growth of blood vessels from surrounding tissue to a solid tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1553] "Substances that increase the risk of neoplasms in humans or animals. Both genotoxic chemicals, which affect DNA directly, and non-genotoxic chemicals, which induce neoplasms by other mechanism, are included. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1554] "A drug that makes tumor cells more sensitive to the effects of chemotherapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1555] "One of a number of chemical compounds found in certain fruits, vegetables and seeds with antioxidant properties and potential antineoplastic properties. As polyphenolic, soluble plant pigments, flavonoids are usually subdivided into 5 subgroups flavonols, flavones, flavonones, flavan-3-ols, anthocyanidins.  Although not considered essential nutrients, some flavonoids may be beneficial to health by strengthening and protecting blood vessels and connective tissue and acting as anti-inflammatory, antihistaminic, and antiviral agents.  As antioxidants, some flavonoids may protect lipids from oxidative damage or retard the formation of cataracts. (NCI04)"                                                                                                                                                                                                                                                                                                                  
 [1556] "Small proteins that function as hormonal signals, synthesized and secreted by one tissue or organ with physiological effects on other tissues or organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1557] "A family of vegetables that includes kale, collard greens, broccoli, cauliflower, cabbage, Brussels sprouts, and turnips. These vegetables contain substances that may protect against cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1558] "A family of anticancer drugs. The topoisomerase enzymes are responsible for the arrangement and rearrangement of DNA in the cell and for cell growth and replication. Inhibiting these enzymes may kill cancer cells or stop their growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1559] "Aptamers are double-stranded DNA or single-stranded RNA oligonucleotide sequences with the capacity to recognize target molecules with high affinity and specificity. Fundamentally distinct from antibodies, aptamers mimic their properties and have emerged as a promising class of molecules in both therapeutic and diagnostic formats. In having small size (8-15 kDa) relative to antibodies (150 kDa), aptamers are candidates for rapid tumor penetration and blood clearance. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1560] "A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 1 (FGF-1. Because of the mitogenic and angiogenetic effects of FGF-1 on fibroblasts and endothelial cells, therapeutic FGF-1 has a potential role in wound healing; because FGF-1 has been shown to induce neurogenesis, therapeutic FGF-1 may have a role in nerve regeneration. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1561] "Any chemical compound, biological object, physical factor in a concentration or amount that adversely alters the physical, chemical, or biological properties of the environment. The term includes pathogens, toxic metals, carcinogens, oxygen-demanding materials, radiation, natural substances, synthetic industrial chemicals, biocides and all other harmful substances and factors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1562] "A vaccine synthesized from a peptide that mimics the antigen located on the surface of a patient's own tumor cells and elicits an immune response against the tumor cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1563] "The most prevalent of nonprotein nitrogenous compounds circulating in the blood used as an indicator of liver and kidney function.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1564] "A recombinant agent which is chemically identical to or similar to the endogenous protein cytokine interleukin-1 (IL-1). The IL-1  precursor is produced by monocytes, activated macrophages, and other cell types; mature IL-1 is generated by proteolytic cleavage by proteases such as IL-1-beta converting enzyme (ICE). This agent enhances T cell proliferation and B cell growth and differentiation and induces the expression of proinflammatory cytokines. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1565] "A drug used to relieve pain or discomfort associated with chronic inflammation of the bladder. It is also being evaluated for its protective effects on the gastrointestinal tract in people undergoing radiation therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1566] "The citrate salt of a nonsteroidal triphenylethylene antiestrogen.  Chemically related to tamoxifen, toremifene is a selective estrogen receptor modulator (SERM).  This agent binds competitively to estrogen receptors, thereby interfering with estrogen activity.  Toremifene also has intrinsic estrogenic properties, which is manifested depending on the tissue or species. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1568] "A cysteinyl analogue that arrests cells in mitosis and induces apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1569] "An aziridine alkylating agent that cross-links with DNA, causing inhibition of DNA synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1570] "An aziridine alkylating agent that cross-links with DNA, causing inhibition of DNA synthesis. It was studied for use in colon cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1571] "An acid azo dye commonly used as a stain to distinguish viable from non-viable cells. It was previously used to treat trypanosomiasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1572] "The hydrochloride salt form of Raloxifene. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1573] "A quassinoid phytochemical isolated from Cedronia granatensis and other plant species with potential antineoplastic activity.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1574] "A quassinoid phytochemical isolated from the plant Brucea antidysenterica with potential antineoplastic activity.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1575] "A quassinoid phytochemical isolated from the plant Brucea antidysenterica with potential antineoplastic activity.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1576] "A man-made consensus type-I interferon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1577] "A quassinoid phytochemical isolated from Simaba cedron and other plant species with potential antineoplastic activity.  Chaparrin is a mixture of compounds that includes flavonoids, antioxidants, and nordihydroguaiaretic acid (NDGA).  NDGA is an antioxidant and lipoxygenase inhibitor that promotes cell differentiation, induces G1 phase cell-cycle arrest, and causes apoptosis in certain cancer cell lines.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1578] "A quassinoid phytochemical isolated from the plant Brucea antidysenterica with potential antineoplastic activity.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1579] "A broad spectrum protein tyrosine kinase inhibitor that inhibits epidermal growth factor receptor, GTPase activity of transducin, aldosterone secretion in response to Angiotensin II, and suppresses the activation of MAP kinases. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1580] "A compound that inhibits the Protein-Tyrosine Kinase Activity of p56lck. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1581] "A quassinoid glycoside phytochemical isolated from the plant Picrasma ailanthoides with potential antineoplastic activity.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1582] "A third-generation DNA repair inhibitor that modulates multi-drug resistance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1583] "An anticancer drug that increases the effectiveness of fluorouracil. Also called eniluracil."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1584] "A quassinoid phytochemical isolated from the tropical plant Cedronia granatensis with potential antineoplastic and chemopreventive activities.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1585] "Cancell (Entelev or Cantron), is a liquid that has been produced in various forms, principally by two manufacturers, since the late 1930s.  The exact composition of Cancell/Entelev is unknown, but the U.S. Food and Drug Administration (FDA) has listed the components as inositol, nitric acid, sodium sulfite, potassium hydroxide, sulfuric acid, and catechol.  NCI studies determined that the mixture lacked substantial antitumor activity. (from CancerNet)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1586] "A synthetic peptide vaccine consisting of the carboxy terminal peptide (CTP) of human beta chorionic gonadotropin (beta-hCG).  Vaccination with CTP-37 stimulates the host immune system to produce antibodies against beta-HCG, leading to a decrease in the proliferation of tumor cells that overexpress beta-HCG. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1587] "A potent and specific antagonist of the HIV-1 co receptor CXCR4 which inhibits HIV replication and efficiently blocks cell-surface-expressed HIV-1 envelope-induced apoptosis in uninfected cells.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1588] "A member of the tyrphostin family of tyrosine kinase inhibitors that inhibits epidermal growth factor receptor, blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death. Inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of Mycosis fungoides tumor cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1589] "A substance that is being studied as a treatment for cancer .  It belongs to the family of drugs called endothelin-1 protein receptor antagonists."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1590] "A member of the tyrphostin family of tyrosine kinase inhibitors, that selectively inhibits epidermal growth factor receptor kinase activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1591] "A member of the tyrphostin family of tyrosine kinase inhibitors that inhibits epidermal growth factor receptor and blocks metavanadate-induced respiratory burst in alveolar macrophages. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1592] "An antihypertensive agent that exerts its effect by inhibiting angiotensin converting enzyme and neutral endopeptidase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1593] "An alkyl sulfonate with potential antineoplastic activity.  Piposulfan alkylates DNA, thereby producing DNA interstrand crosslinks and DNA strand breaks and inhibiting DNA replication.  This agent has been shown to exhibit antitumor activity in an animal model of prostate cancer. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1594] "A murine IgG1, kappa light chain MAb with an affinity for the ovarian cancer associated antigen CA125. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1595] "A member of the tyrphostin family of tyrosine kinase inhibitors that inhibits epidermal growth factor receptor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1596] "A protein isolated from the cyanobacterium Nostoc ellipsosporum.  Inactivates the human immunodeficiency virus in vitro, apparently at the level of adsorption to the target cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1597] "A quinazoline derivative that selectively inhibits EGFR kinase activity and suppresses the growth of psoriatic keratinocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1598] "A 20-base phosphorothioate oligonucleotide targeting the 3'-untranslated region of human Protein Kinase C-alpha (PKC-a) mRNA, inhibiting PKC-a expression. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1599] "A monoclonal antibody that blocks the action of a cytokine called tumor necrosis factor alfa. It is being studied  in the treatment and prevention of weight loss and loss of appetite in patients with advanced cancer.  It belongs to the family of drugs called monoclonal antibodies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1600] "A mixed backbone oligonucleotide targeting the human cytomegalovirus UL36 gene.  Clinical development has been terminated.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1601] "A recombinant form of neurotrophic growth factor that regulates the development and maintenance of motor neurons expressing trk B receptor tyrosine kinase, with potential use in neurodegenerative disorders. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1602] "A formulated therapeutic analogue of a member of the endogenous CC chemokines with potential antineoplastic activity. Expressed by various lymphoid tissues and secondary lymphoid-tissue chemokine is chemotactic for B and T lymphocytes and dendritic cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1603] "A new generation of platinum based compounds that has extended spectrum anti-cancer activity and is designed to overcome platinum drug resistance. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1604] "A fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites.  As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells.  FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                           
 [1605] "A protein that can be linked to a chemotherapy drug to deliver the drug directly to the tumor with fewer side effects.  It is being studied as a treatment for cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1606] "A substance that is being studied as an anticancer drug."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1607] "A hybrid polar compound that induces terminal differentiation and/or apoptosis in various transformed cells.  It is an inhibitor of histone deacetylase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1608] "A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity.  Neovastat competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cell receptor, thereby inhibiting endothelial cell proliferation.  This agent also inhibits matrix metalloproteinases, stimulates tissue plasminogen activator, and activates caspase-mediated apoptotic pathways in endothelial cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1609] "A natural antioxidant formulation containing herbs and/or vitamins formulated to stimulate the immune system and neutralize or eliminate free radicals and toxins.  Some plant-derived ingredients include: Ginkgo biloba, Ginseng sp., Allium sativa (garlic clove), Uva Ursi, Alfalfa Leaf, Curcuma longa (turmeric), Echinacea sp., Burdock and others. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1610] "A humanized monoclonal IgG1 antibody to alpha(v)beta(3) integrin with potential antineoplastic activity.  Vitaxin blocks the binding of ligands, such as vitronectin, to endothelial cell surface-expressed alpha(v)beta(3) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1611] "A biologic maker associated with bladder carcinoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1612] "A small roll of finely cut tobacco for smoking, enclosed in a wrapper of thin paper. (WEBS84)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1613] "A dietary protein isolated from soybeans that contains isoflavone phytoestrogens.  Soy protein isolate has been shown to reduce tumor incidence and growth in some animal studies, possibly by modulating estrogen metabolism, reducing tumor cell proliferation, and inducing tumor cell apoptosis.  Soy protein isolate may also inhibit endothelial cell proliferation.  Isoflavone phytoestrogens display mild estrogen-like activities which may regulate hormone balance and reduce risk of breast cancer, heart disease, and osteoporosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1614] "An anticancer drug that inhibits tumor cells from multiplying by interfering with cells' ability to make DNA. Also called ICI D1694."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1615] "A selective estrogen receptor modulator that blocks estrogen from breast cancer cells, causing cancer cell starvation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1616] "A recombinant, humanized anti-CD33 monoclonal antibody attached to the cytotoxic antitumor antibiotic calicheamicin.  Calicheamicin binds to the minor groove of DNA, causing double strand DNA breaks and results in inhibition of DNA synthesis.  In this combination, the antibody binds to and is internalized by tumor cells expressing CD33 antigen (a sialic acid-dependent glycoprotein commonly found on the surface of leukemic blasts), thereby delivering the attached calicheamicinl to CD33-expressing tumor cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1617] "A topical preparation to reduce the risk of, and treat skin reactions to, radiation therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1618] "A radioactive substance (yttrium-90) joined by a large chemical link (DOTA) to biotin, a vitamin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1619] "A radioactive substance used in cancer therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1620] "A drug that may inhibit the growth of malignant tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1621] "A synthetic hydroxamic acid derivative with potential antineoplastic activity.  Prinomastat inhibits matrix metalloproteinases (MMPs) (specifically, MMP-2, 9, 13, and 14), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.  As a lipophilic agent, prinomastat crosses the blood-brain barrier.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1622] "An anticancer drug that is a combination of a monoclonal antibody and a radioisotope (yttrium-90). Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.  Also called IDEC-Y2B8 monoclonal antibody."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1623] "A compact roll of tobacco leaves prepared for smoking. (WEBS84)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1624] "A chemical compound (such as protein, fat, carbohydrate, vitamins, or minerals) that make up foods.  These compounds are used by the body to function and grow."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1625] "Amine having a univalent organic group (as phenyl) derived from an aromatic hydrocarbon by the removal of one hydrogen atom. (ISV)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1626] "Pharmacological agents that are used for recreational, not medical, purposes and can become habituating or addictive, especially a narcotic agent. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1627] "A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder.  Also produced by the Chinese black bear liver, ursodiol has been used in the treatment of liver disease for centuries.  This agent dissolves or prevents cholesterol gallstones by blocking hepatic cholesterol production and decreasing bile cholesterol.  Ursodiol also reduces the absorption of cholesterol from the intestine. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1628] "An injectable sodium succinate salt form of Hydrocortisone. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1629] "A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species.  Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis.  Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1630] "(sel-EK-tiv ESS-tro-jen re-SEP-tor MOD-yew-lay-tor) SERM.  A drug that acts like estrogen on some tissues but blocks the effect of estrogen on other tissues. Tamoxifen and raloxifene are SERMs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1631] "A therapeutic glycoprotein hormone synthesized by recombinant DNA technology or purified from biological sources, whose endogenous counterpart follicle stimulating hormone (FSH) stimulates and maintains the normal functions of reproductive system in males and females. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1632] "A synthetic version of naturally occuring interferons that have immunomodulatory, antiviral and antiproliferative activities. It may exert antitumor activity by anti-angiogenic and cell differentiation activities. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1633] "A sulphonated distamycine A derivate that blocks the binding of growth factors and causes anti-angiogenic activities. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1634] "A synthetic organic compound that selectively inhibits the kinase activity of Mitogen-Activated Protein kinase, preventing cytokine and prostaglandin E2 production. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1635] "A member of the cryptophycin family of antitumor agents that binds to microtubules, inducing growth arrest and apoptosis in solid tumors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1636] "A substance that is being studied as an anticancer drug.  It belongs to the family of platinum-based drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1637] "A mixture of 8 chinese herbs which are reported to improve immune function.  There is some clinical evidence that it may be useful as a treatment for prostate cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1638] "A synthetic tricyclic derivative of carboxamide with antineoplastic properties.  Lonarfanib inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins.  Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis.  Mutated ras proteins have been found in a wide range of human cancers. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1639] "A melanoma vaccine consisting of an extract of allogeneic tumor cell lines mixed with the RIBI adjuvant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1640] "A derivative of quinolone Semaxanib blocks ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), thereby inhibiting VEGF-stimulated endothelial cell migration and proliferation and decreasing the density of microvessels supplying tumors.  This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. Semaxanib has been studied for potential antineoplastic properties. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1641] "A nonsteroidal anti-inflammatory agent that selectively inhibits cox-2, interfering with prostaglandin synthesis.  It may exhibit antiproliferative and antiangiogenesis activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1642] "A drug that is being studied for its ability to enhance the effectiveness of fluorouracil and prevent gastrointestinal side effects caused by fluorouracil. It belongs to the family of drugs called antimetabolites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1643] "A cyclic Arg-Gly-Asp peptide with potential antineoplastic activity.  Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1644] "An anticancer drug that belongs to the family of drugs called mitotic inhibitors. It inhibits the growth of cancer cells by preventing cell division."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1645] "A macrocyclic antifungal antibiotic, radicicol oxime derivative that binds and selectively depletes heat shock protein 90 (Hsp90) chaperone, a signaling molecule involved in signal transduction that plays a vital role in tumor cells growth. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1646] "An antidepressant drug."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1647] "An herbal supplement used commonly to alleviate symptoms of benign prostatic hyperplasia.  In vitro studies show that it may also have anti-cancer properties specific for prostate cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1648] "A drug that inhibits blood clotting.  It is being studied in cancer treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1649] "An anticancer drug that belongs to the family of drugs called enzyme inhibitors. It may inhibit the transformation of normal cells into cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1650] "A radioactive isotope of iodine, a nonmetallic element of the halogen group.  With a half-life of 60 days, iodine 125 occurs naturally and can be produced artificially.  This agent has both therapeutic and diagnostic uses, particularly in thyroid disease. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1651] "An anticancer drug that belongs to the family of drugs called bacterial immunotoxins. BL22 is a bacterial toxic substance linked to an antibody that attaches to tumor cells and kills them."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1652] "An anticancer drug that belongs to the family of drugs called mitotic inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1653] "An anticancer drug that inhibits the growth of cancer cells by preventing cell division."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1654] "A covalent conjugate of recombinant interferon alpha, subtype 2b, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent.  The biological activity of this agent is derived from its interferon alpha-2b protein moiety.  The PEG moiety lowers the clearance of interferon alpha-2b, thereby extending the duration of its therapeutic effects.  Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects; it may also reduce the protein's ability to produce an immune response. (NCI04)"                                                                                                                                                                                                                                                                                                                    
 [1655] "A recombinant chimeric dual G-CSF and IL-3 receptor agonist.  Leridistim binds with high affinity to both the interleukin-3 (IL-3) and granulocyte colony-stimulating factor (G-CSF) receptors, thereby stimulating the production and maturation of neutrophils, platelets, and lymphocytes after chemotherapy.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1656] "A recombinant agent, which is chemically identical to or similar to the endogenous cytokine transforming growth factor-beta-3 (TGF-beta-3). TGF-beta-3 modulates cell growth and immune function and may promote or inhibit tumor growth, depending on the tumor cell type; this agent may also suppress host immune system recognition of and/or response to tumor cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1657] "A polysulphonated naphthylurea with potential antineoplastic activity.  Suramin sodium uncouples G-proteins from their receptors and inhibits reverse transcriptases, topoisomerases, cell surface binding of various growth factors, cellular transport of folate compounds, protein tyrosine phosphatases, and angiogenesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1658] "The hydrochloride salt for of Aminolevulinic Acid. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1659] "An antibiotic/antifungal drug used to treat infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1660] "A drug that is being studied as a treatment for cancer.  It belongs to the family of drugs called dipeptidyl boronic acids.  Also called PS-341."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1661] "A drug that is being studied as a treatment for solid tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1662] "A prodrug in which a peptide is covalently conjugated with the anthracycline antineoplastic antibiotic doxorubicin.  This complex is hydrolyzed by the enzyme prostate-specific antigen (PSA), resulting in the formation of doxorubicin and leucine-doxorubicin.  Selective targeting of these drugs to prostate tumor cells occurs because the hydrolyzing PSA enzyme is localized to the prostate gland.  Doxorubicin and leucine-doxorubicin intercalate into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  These agents also produce toxic free-radical intermediates and interact with cell membrane lipids causing lipid peroxidation. (NCI04)"                                                                                                                                                                                                                                                                     
 [1663] "A long-acting recombinant therapeutic analog of human granulocyte colony-stimulating factor (G-CSF), is produced by pegylation of the amino-terminus of filgrastim.  Pegfilgrastim binds to specific cell surface receptors and stimulates the differentiation of hematopoietic cells; stimulates the production and maturation of neutrophil precursors; and, similar to filgrastim, enhances the functions of mature neutrophils. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1664] "A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors. Also called ZD 1839."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1665] "A nonthiol nonpeptidic small molecule farnesyltransferase inhibitor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1666] "A fully human monoclonal antibody that binds to epidermal growth factor receptor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1667] "A semi-synthetic analog of the natural product epothilone B that stabilizes microtubules and causes cancer cell death. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1668] "A Paclitaxel analog that has similar mechanism of action as paclitaxel but exhibits superior activity compared to paclitaxel. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1669] "Based upon the natural F plasmid of E. coli.  Inserts up to 300 Kb can be cloned and stably maintained as circular molecules."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1670] "An antineoplastic oligosaccharide anthracycline antibiotic isolated from the bacterium Streptomyces galilaeus.  Aclacinomycin B intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1671] "A poorly adsorbed analog of prednisolone.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1672] "An inhibitor of histone deacetylase.  It is a benzamide derivative and acts as an antitumor agent through inhibition of deacetylase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1673] "A synthetic compound that binds to the DNA minor groove and cause anti tumor activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1674] "A nuclease-stabilized synthetic ribozyme with potential antineoplastic activity.  Angiozyme cleaves the mRNA encoding vascular endothelial growth factor 1 (VEGF-1, or Flt-1), thereby specifically inhibiting VEGF-stimulated angiogenesis, tumor growth, and metastasis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1675] "An epidophyllotoxin analogue that inhibits topoisomerase II and induces apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1676] "A second-generation taxoid derivative that exhibits activity against multidrug resistant cancer cell lines and other solid tumors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1677] "An orally bioavailable anilinophthalazine with potential antineoplastic activity.  PTK787/ZK 222584 binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis.  This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1678] "A non-steroidal anti-inflammatory agent that selectively inhibits cox-2 and causes the inhibition of prostaglandin synthesis. It may exhibit antiproliferative and antiangiogenesis activities. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1679] "A drug that may kill cancer cells by blocking the production of a protein that makes cancer cells live longer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1680] "A pyrrolo-pyrimidine EGFR protein kinase inhibitor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1681] "A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called protein kinase C (PKC) inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1682] "An anticancer drug that belongs to the family of drugs called bisphosphonates. It affects cancer cell receptors governing cell growth and cell death."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1683] "A substance that is being studied as a treatment for cancer.  It belongs to a family of drugs called antiestrogens."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1684] "A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called matrix metalloproteinase inhibitors (MMPIs)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1685] "A formulation composed of Lurtotecan, a topoisomerase I inhibitor, contained within the hollow interior of the liposome. Current use: treatment for solid tumors and hematological malignancies including ovarian and small cell lung cancers. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1686] "A drug being studied in the treatment of cancer.  It belongs to a family of drugs called topoisomerase inhibitors. It is related to the anticancer drug camptothecin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1687] "(dar-be-POE-e-tin AL-fa) A substance made in the laboratory that stimulates the bone marrow to produce red blood cells. It belongs to the family of drugs called antianemics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1688] "An arabinoxylane polysaccharide composed of the hemicellose-Beta extract of rice bran, treated with enzymes from Shiitake mushrooms, that exerts antitumor and antiviral activity by increasing the level of natural killer cells activation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1689] "A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called tyrosine kinase inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1690] "A substance that makes tumor cells more sensitive to radiation; it can also enhance tumor images using magnetic resonance imaging (MRI). Motexafin gadolinium belongs to the family of drugs called  metalloporphyrin complexes.  Also called gadolinium texaphyrin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1691] "A modified nucleotide that interacts with thymidylate synthase (TS), an enzyme important in DNA synthesis and over expressed in most cancer cells. NB1011 enters the cell as a harmless substrate for TS, upon interaction, it is converted into a deadly toxin that kills the tumor cell. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1692] "A Vitamin D3 analog that has the ability to induce differentiation and inhibit the proliferation of tumor cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1693] "A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called angiogenesis inhibitors.  Also called SU006668."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1694] "A 25-mer mixed-backbone oligonucleotide targeting the gag gene in the human immunodeficiency virus (HIV-1), inhibiting HIV replication. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1695] "A camptothecin analogue that exerts antitumor activity by inhibiting topoisomerase II. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1696] "A recombinant, humanized monoclonal antibody directed against CD22, a cell surface glycoprotein present on mature B-cells and on many types of malignant B-cells.  After binding to CD22, epratuzumab's predominant antitumor activity appears to be mediated through antibody-dependent cellular cytotoxicity (ADCC). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1697] "An orally bioavailable antiangiogenic isocoumarin with potential antineoplastic activity.  NM-3 inhibits vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor, thereby inhibiting endothelial cell proliferation.  This agent also induces apoptosis by a mechanism involving reactive oxygen species. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1698] "A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called DNA intercalators."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1699] "A derivative of adenoviruses used for studies of gene transfer.  Unlike most other vectors, adenovirus vectors have the ability to infect post-mitotic cells.  This makes them especially useful for gene transfer to neuronal cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1700] "A substance that blocks the activity of a progestin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1701] "(AN-tih-KAR-sin-o-JEN-ik) Pertaining to something that prevents or delays the development of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1702] "Antimitotic pseudopeptides isolated from the sea hare that exhibits antiproliferative properties by interacting with tubulin and inducing apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1703] "Environmental Estrogens are a variety of natural and synthetic substances that may mimic natural estrogen hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1704] "RAEB: Hydrocarbons containing multiple halogen substituents (Br, Cl, Fl, I)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1705] "RAEB: Monoclonal antibodies used for clinical diagnosis"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1706] "Peptides containing phosphoryl group substituents on the R groups of amino acids, principally serine, threonine, and tyrosine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1707] "Physical agents, such as radiation, that may have a role in development of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1708] "RAEB: factors which regulate some aspect of physiology, produced by the body, rather than administered externally"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1709] "Cloning vectors derived from vaccinia virus or other pox viruses, eg canarypox.  Usually used for expression of foreign genes in mammalian cells, especially as a component of a vaccine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1710] "Folic acid analogs containing a pteridine base, a two-ring heterocyclic aromatic compound, and are used to interfere with folic acid."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1711] "RAEB: Usually drugs, but vaccines would also be included, that specifically or preferentially interfere with the action of the ras oncogene. Examples include carboxyaminoimidazole (CAI), Iovastatin, limonene, and perillyl alcohol."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1712] "Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1713] "Compounds that inhibit the action of topoisomerase I (see Topoisomerase Inhibitors).  The alkaloid camptothecin is the most commonly used inhibitor of topoisomerase I.  Water-soluble derivatives of camptothecin, such as CPT-11 and topotecan, have been examined for antineoplastic activity in colorectal cancer, non--small-cell lung cancer, lymphoma, ovarian cancer, head and neck cancer, pancreatic cancer, and breast cancer"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1714] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1715] "Protein fragments that are derived specifically from tumor cells and presented to T cells by Major Histocompatibility Complex (MHC) molecules expressed on antigen presenting cells or even on the tumors themselves.  Often used alone or as conjugates with other molecules as experimental tumor vaccines. (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1716] "RAEB: Any anticancer drug derived from microorganisms, plants, or animals; also, synthesized versions of these substances or their derivatives. Examples are antibiotics, taxol and other taxanes, vinca alkaloids, VP-16 and other epipodophyllotoxins. Hormones, immunologic factors, and gene therapy are not included in this category; the key point is that the substance must be pharmacologically active, not merely a replacement for a missing or defective enzyme, hormone, or other factor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1717] "A category of organic or inorganic substances, elements, and isotopes used in research or for the prevention, diagnosis, and /or treatment of disease states.  Includes biologically active substances that are either synthetically manufactured or endogenous substances extracted and processed to be reintroduced into an organism.  Chemicals and drugs also include naturally occurring or synthetically produced substances required to maintain life and hazardous substances. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1718] "A natural, synthetic or semi-synthetic substance including endogenous body substance used to diagnose, prevent, maintain, treat or analyze abnormal and normal biological functions in vivo or in vitro. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1719] "A substance that closely resembles LHRH, which controls the production of sex hormones. However, LHRH agonists affect the body differently than does LHRH. LHRH agonists keep the testicles from producing hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1720] "Organic compounds that contains phosphorus and a metal-carbon bond with Boron atoms. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1721] "Formulated therapeutic analogs of one of a number of endogenous chemokines other than those classified as CXC, CC, C, or CX3C (previously known as alpha, beta, gamma, and delta, respectively). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1722] "Substances that are grouped or classified by chemical composition.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1723] "Substances that are grouped and described by their effects on biological functions rather than by their chemical structures. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1724] "Historically, the term \"aromatic\" originally referred to the smell of selected compounds that later were found to contain benzene or fused benzene rings in the structure. In a structural sense, it designates compounds that, in accordance with the theory of Huckel, have a cyclic, delocalized (4n+2) pi-electron system. This includes arenes and their substitution products. E.g. benzene, naphthalene, toluene. The term has been generalized to include aromatic heterocyclic structures, such as thiophene and pyridine, but it is more precise to call compounds of the latter type heteroaromatic."                                                                                                                                                                                                                                                                                                                                                                                  
 [1725] "Organic or inorganic compounds that contain nitrogen as an integral part of the molecule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1726] "A cloning vector based upon the bacteriophage P1, but more modified than a P1-vector.  Used for introduction of foreign or recombinant DNA into E. coli.  Hold a larger insert than plasmids or cosmids.  PACs are maintained as circular molecules.  These vectors contain sequences necessary for packaging by P1 particles, as well as other P1 required elements.  Inserts up to 100Kb can be cloned in PACs"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1727] "A cloning vector derived from the bacteriophage P1."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1728] "A plasmid especially designed for cloning of DNA or construction of recombinant DNA molecules.  Such a cloning vector will usually have convenient restriction enzyme sites to facilitate the introduction of foreign DNA by ligation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1729] "Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity.  Live-attenuated vaccines are used when a CD8+ T Cell (cellular cytoxicity) response is desired."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1730] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1731] "A family of drugs obtained from bacteria that interfere with cell division.  Some epithilones are being studied as treatments for cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1732] "Toxins present in food or water."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1733] "A class of antimitotic compound, from a marine cyanobacterium species (blue green alga) that inhibits tubulin polymerization and interferes with cell proliferation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1734] "A soluble protein immunogen used as a model antigen to study antibody:antigen binding and B- and T-cell responses in the laboratory. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1735] "Exhibiting a cyclic structure containing at least one amino (NH2) group, some Heterocyclic Amines are carcinogenic chemicals formed from cooking meat such as beef, pork, fowl, and fish when amino acids and creatine (found in muscle) react at high temperatures. About 17 identified heterocyclic amines that result from cooking meat may increase human cancer risk. Because of the high temperatures used, frying, broiling, and barbecuing produce the largest amounts of heterocyclic amines. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1736] "A class of enediyne antineoplastic antibiotics that are isolated from various Streptomyces bacterial species.  After cycloaromatization, the enediyne core of these antibiotics is converted to a benzene diradical intermediate that removes hydrogens from deoxyriboses along the minor groove of DNA, resulting in single- and double-strand breaks and apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1737] "An antitumor antibiotic of the enediyne class. It has demonstrated high DNA cleavage activity in the presence of NADPH, antimicrobial and tumor growth-inhibiting properties. Dynemicin recognizes and cleaves conformationally flexible regions of DNA. It attacks bases at 3'-side of purine residues such as 5'-AG, 5'-AT, and 5'-GC sequences. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1738] "Molecules, of an unidentified chemical nature, that participate in signal transduction processes in the cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1739] "Substances introduced into the body by dietary means."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1740] "Plant-derived compound used to treat cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1741] "A chemical that influences the properties of another chemical or biological function. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1742] "A cyclic compound. any compound in which the constituent atoms, or any part of them, form a ring. Used mainly in organic chemistry. SYN closed chain compound, ring compound."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1743] "A class of agents that induce the differentiation or maturation of cells, specifically neoplastic cells, resulting in decreases in tumor growth and metastasis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1744] "Drugs which reduce the fatigue and weight loss often associated with cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1745] "The RNA sequence produced by transcription. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1746] "Dyes, indicators, and other reagents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1747] "A murine and humanized monoclonal antibody that targets epitopes of epithelial glycoprotein mucin (MUC-1) on breast cancer surfaces. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1748] "A family of tumor antigens.  Expressed in adult normal testis and some sarcomas, melanomas, nonsmall cell lung carcinomas, head and neck tumors, and bladder tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1749] "A chemical Element or Isotope is a substance composed of atoms with similar chemical properties and whose nuclei all contain an equivalent number of protons. Isotopes of a chemical element are atoms whose nuclei have the same atomic (proton) number but different atomic weight, due to variation in the number of neutrons in the nuclei. Several isotopes of the same element can often be found in nature. Variation in neutron number can affect nuclear stability and subject some isotopes to nuclear decay; known as radioactive isotopes (radioisotopes). Some radioisotopes are used for biomedical and physical research or in medical treatment and diagnostics. Based on subatomic structure, chemical elements are organized in a periodic table. (NCI04)"                                                                                                                                                                                                                        
 [1750] "(TOO-mer ne-KRO-sis) A type of biological response modifier (a substance that can improve the body's natural response to disease).  Three types of tumor necrosis factor have been identified: alpha, beta, and gamma. Tumor necrosis factor seems to play a role in the breakdown of cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1751] "Synthetic linkers used to generate nucleic acid miniduplexes that are capable of binding to nucleic acid-binding proteins.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1752] "A radioactive isotope that is used to destroy cancer cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1753] "A yeast artificial chromosome containing a specific DNA fragment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1754] "Food substances obtained from plant source. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1755] "Compounds causing hyperacetylation of histone deacetylase, an enzyme involved in the regulation of transcription, causing inhibition of cell differentiation and induction of apoptosis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1756] "Organic acids that have oxygen atoms in the acidic groups. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1757] "The epoxy containing amino acid of HC toxin, a histone deacetylase inhibitor.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1758] "Processed or unprocessed substances obtained from animal, plant, microorganism and mining source that provide nutrients for living organisms to maintain biological processes or functions. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1759] "Oil extracted from nuts. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1760] "A recombinant vaccine of different types of HPV proteins which are well-conserved within types with a significant inter-type variation.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1761] "A non-glycosylated recombinant human alpha interferon, subtype 2a, produced in the bacterium E. coli.  Interferon alfa-2a binds to its specific cell-surface receptor, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune modulating effects. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1762] "A non-glycosylated recombinant interferon alpha, subtype 2b, used as an antiviral and antineoplastic agent.  Alpha interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1763] "A nutraceutical is any food or food ingredient considered to provide medical or health benefits, including the prevention and treatment of disease.  Food-based (nutrition) substances that have pharmaceutical effects on human health."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1764] "A class of plant alkaloids which include the capsaicins"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1765] "Substances contained in tobacco or tobacco by-products that increase the risk of neoplasms in humans or animals. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1766] "A radiopharmaceutical comprised of a thymidine analog, 5-iodo-2''-deoxyuridine (idoxuridine), labelled with the Auger electron emitter Iodine 125 that has been used as an assay for testing cell-mediated cytotoxicity and exhibits cytotoxicity by incorporating into DNA, causing DNA strand breaks. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1767] "A monoclonal antibody that recognizes tenascin.  Shows promise as a treatment for glioma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1768] "A monoclonal antibody used in immunotherapy and immunodetection of various types of cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1769] "Monoclonal antibody that recognizes a tumor-associated antigen expressed on the cell surface of most renal cell carcinomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1770] "An anti-CD45 antibody (BC8) that has specificity for hematopoietic tissues and used in targeted immunotherapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1771] "Agents used in gene therapy including viral or non viral vectors, cytokines, gene complexes and genetic materials. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1772] "Peptides built of D-amino acids in the reversed sequence order.  These may adopt structures similar to their L-counterparts while being more resistant to proteolytic degradation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1773] "A peptide resembling the complementary determining region of an antibody and retaining its specificity.  These are being studied for therapeutic and research use."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1774] "Lutein (LOO-teen) is a oxygenated carotenoid found in vegetables and fruits.  lutein is found in the macula of the eye, where it is believed to act as a yellow filter. Lutein acts as an antioxidant, protecting cells against the damaging effects of free radicals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1775] "Agents used to enhance image formation of body structures and functions in the detection and diagnosis of disease by anatomic or receptor localization or being activated by processes in the body. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1776] "A family of drugs that interfere with cell communication and may prevent tumor growth. They are being studied as a treatment for cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1777] "Substances that either stabilize DNA-protein complexes damaging DNA (e g., teniposide), or those that inhibit the catalytic activity of the enzyme (e.g., merbarone, ICRF-187). Despite their differences in action, these agents all block cells in G2/M"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1778] "A substance originally isolated from the marine mollusk Dolabella auricularia with potential neoplastic activity.  Dolastatin 9 binds to tubulin and blocks microtubule assembly, thereby inhibiting mitosis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1779] "A class of antiangiogenic agents with antimetastatic properties.  A matrix metalloproteinase inhibitor blocks the activities of matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation and inhibiting angiogenesis, tumor growth and invasion, and metastasis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1780] "An agent or endogenous factor that inhibits angiogenesis by blocking the action of an endogenous, pro-angiogenic substance(s). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1781] "The hydrochloride salt form of Deferoxamine. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1782] "CancerVax is an allogenic polyvalent vaccine composed of irradiated but viable cells from three melanoma cell lines and Bacille Calmette-Guerin (BCG). The vaccine was shown to induce humoral and cellular immune responses against multiple tumor antigens present on melanoma cells. A significant correlation between the magnitude of immune responses to the vaccine and the overall survival of patients receiving adjuvant therapy with CancerVax after surgical resection of stage III and IV melanoma was reported. Vaccine testing in patients with advanced colon cancer merits further investigation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                           
 [1783] "A group of phytochemicals isolated from several species of the plant family Simaroubaceae with potential antineoplastic activity.  Quassinoid agents also exhibit antimalarial, antiprotozoal and antiproliferative activities.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1784] "A group of quassinoid phytochemicals extracted from species of the plant Brucea with potential antineoplastic activity.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1785] "A class of linear or cyclic antineoplastic antibiotics isolated from microorganisms or synthetically derived.  These antibiotics exhibit potent antitumor, antibiotic, and immunosuppressive properties. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1786] "A cancer vaccine that uses a viral vector system derived from the canarypox virus engineered to target the carcinoembryonic antigen (CEA). It causes infected cells to temporarily display CEA and activates the immune system to attack the tumor cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1787] "GVAX cancer vaccines are autologous cell vaccines comprised of tumor cells which have been irradiated and genetically modified to secrete granulocyte-macrophage colony stimulating factor (GM-CSF), a hormone which plays a key role in stimulating the body's immune response to vaccines."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1788] "A patient-specific vaccine composed of surgically removed patient's tumor, which is cultured and genetically modified to secrete Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), which is then irradiated prior to vaccinating the patient. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1789] "Vaccine prepared from cells of the patient. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1790] "An autologous-cell vaccine for melanoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1791] "A vaccine consisting of autologous cancer cells modified with the hapten, Dinitrophenyl. The treatment program consists of multiple intradermal injections of irradiated DNP-modified autologous tumor cells mixed with bacillus Calmette-Guerin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1792] "Vaccine made of cells from one or more different patients. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1793] "An autologous vaccine comprised of irradiated tumor cells obtained from the patient after surgery and it is administered along with the BCG vaccine. It is designed to provoke a specific immune response against cancer cells. Current use: potential treatment for colon, bladder, ovarian, and head and neck cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1794] "A cell-based vaccine composed of autologous antigen-presenting peripheral blood mononuclear cells (enriched for a dendritic cell fraction) that have been exposed to a recombinant protein consisting of granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to prostatic-acid phosphatase (PAP), a protein expressed by prostate cancer cells.  When the modified cells are administered to the patient, they may stimulate an antitumor T-cell response to prostate cancer cells expressing PAP. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1795] "A vaccine composed of a p53 peptide, a part of the same abnormal protein found in tumor cells, designed to boost the body's immune response to the cancer.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1796] "A vaccine composed of dendritic cells pulsed with peptide epitopes that stimulate cytotoxic T lymphocyte anti-tumor activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1797] "A vaccine composed of dendritic cells pulsed with tumor cells lysates that stimulate a potent and specific cell mediated anti-tumor immune response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1798] "A yeast glycolipid biosurfactant with potential antineoplastic activity.  Mannosylerythritol lipid activates protein kinase signal cascades, resulting in cell differentiation, condensation of chromatin, DNA fragmentation, G1 phase cell-cycle arrest, and apoptosis of tumor cells.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1799] "A ureido-derivative of pyrimidine developed to induce leukemic cell differentiation.  This agent has been shown to induce erythroleukemia cell differentiation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1800] "A ureido-derivative of pyrimidine developed to induce leukemic cell differentiation.  This agent ahs been shown to induce erythroleukemia cell differentiation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1801] "A ureido-derivative of pyrimidine developed to induce leukemic cell differentiation.  This agent has been shown to induce erythroleukemia cell differentiation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1802] "A ureido-derivative of pyrimidine developed to induce leukemic cell differentiation.  This agent has been shown to induce erythroleukemia cell differentiation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1803] "An ureido-derivative of pyridine and a potent inducer of neoplastic cell differentiation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1804] "A ureido-derivative of pyrimidine developed to induce leukemic cell differentiation.  This agent has been shown to induce erythroleukemia cell differentiation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1805] "A ureido-derivative of pyrimidine developed to induce leukemic cell differentiation.  This agent has been shown to induce erythroleukemia cell differentiation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1806] "An ureido-derivative of pyrimidine and a potent inducer of neoplastic cell differentiation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1807] "An immunotoxin composed of an anti-CD30 monoclonal antibody and a toxin moiety, which targets antigen-positive cells and causes cytotoxic activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1808] "An immunotoxin composed of an anti-p80 monoclonal antibody and a toxin moiety, which targets antigen-positive cells and causes cytotoxic activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1809] "Monoclonal recombinant antibody J591 (mAb HuJ591) recognizes the extracellular domain of prostate specific membrane antigen (PSMA), a cell surface peptidase highly expressed by malignant prostate epithelial cells and vascular endothelial cells of numerous solid tumor malignancies. Early results of clinical Phase I and II studies indicate that mAb HuJ591 represents targeted therapy to PSMA and has therapeutic potential in disseminated prostate cancer and other urological and solid tumor malignancies and did not result in a host immune response to the antibody. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                        
 [1810] "An immunotoxin composed of an anti-CD22 monoclonal antibody and a toxin moiety, which targets antigen-positive cells and causes cytotoxic activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1811] "Monoclonal antibody K4-2C10 conjugated with deglycosylated ricin A chain.  This antibody recognizes human endoglin (Transforming Growth Factor P Receptor III), present on tumor vasculature."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1812] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1813] "A genetically engineered monoclonal antibody that targets CD40. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1814] "A substance composed of a monoclonal antibody-enzyme fusion protein (SGN-17), containing a cloned binding region of the L49 monoclonal antibody and the enzyme beta-lactamase, and an inactive prodrug form of Mephalan (SGN-19) used in Antibody Directed Enzyme Therapy (ADEPT). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1815] "A genetically engineered monoclonal antibody that targets CD30, a cell surface antigen that is expressed on many hematologic malignancies. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1816] "A humanized bispecific antibody containing Fab portions reactive with epidermal growth factor receptor (EGFR)-expressing tumor cells and Fc gamma RI (CD64) receptor-expressing effector cells.  MDX-447 has been in clinical trials for solid tumors overexpressing EGFR and glioblastoma multiforme."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1817] "A bispecific antibody containing a patented Trigger antibody and a humanized antibody that targets TAG-72.  TAG-72 is overexpressed in a variety of cancers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1818] "A monoclonal antibody used to purge leukemia cells from bone marrow. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1819] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1820] "A humanized monoclonal antibody that targets the epidermal growth factor receptor and has anti-tumor activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1821] "An anti-idiotypic monoclonal antibody that mimics the ganglioside GD3, a tumor antigen on the surface of certain types of tumor cells and stimulates a stronger immune response to cells expressing natural GD3. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1822] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1823] "A peptide antagonist of gonadotropin-releasing hormone, which suppresses testosterone production. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1824] "A mixed-backbone antisense oligonucleotide that is complementary to a pro-angiogenic vascular endothelial growth factor (VEGF) mRNA sequence.  Because of its antiangiogenic properties, GEM 220 has been studied as a potential antineoplastic agent. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1825] "An agent with steroidal structure that inhibits aromatase causing a reduction in the synthesis of estrogen or blocking estrogen action at the receptor level in the tumor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1826] "A family of drugs that decrease the production of sex hormones (estrogen or testosterone) and slow the growth of tumors that need sex hormones to grow."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1827] "An agent that inhibits dihydropyrimidine dehydrogenase, a rate-limiting enzyme in the catabolism of 5-Fluorouracil and may be used to improve the efficacy of 5-Fluorouracil. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1828] "An anticancer agent that inhibits the oncogenic activity of ras by inhibiting the first step in its post-translational modification and induces apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1829] "A family of drugs that block DNA synthesis and may prevent tumor cell growth. They are being studied as a treatment for cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1830] "(LOO-tin-eye-zing. . .AG-o-nist) LH-RH agonist.  A drug that inhibits the secretion of sex hormones.  In men, LH-RH agonist causes testosterone levels to fall.  In women, LH-RH agonist causes the levels of estrogen and other sex hormones to fall."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1831] "An autologous therapeutic vaccine for the treatment of acute myelogenous leukemia. This vaccine is prepared from blood samples of patients following their first relapse.  Tumor cells extracted from blood sample are modified with hapten, a process that makes the cells appear foreign to the patient's body and results in stimulating immune response against the cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1832] "A 20-mer phosphorothioate oligonucleotide targeting the translation region of human H-RAS mRNA, causing suppression of H-RAS protein expression and tumor cell growth. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1833] "A member of the tyrphostin family of tyrosine kinase inhibitors that inhibits the GTPase activity of transducin and competitively inhibits calcineurin activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1834] "A member of the tyrphostin family of tyrosine kinase inhibitors that exhibits anti-proliferative activity by selectively inhibiting the platelet-derived growth factor receptor tyrosine kinase. It inhibits phosphorylation, uncouples oxidative phosphorylation and induces apoptosis and cell growth arrest in certain cancer cell lines. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1835] "A member of the Tyrphostin family of tyrosine kinase inhibitors that inhibits epidermal growth factor receptor tyrosine kinase. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1836] "A member of the Tyrphostin family of tyrosine kinase inhibitors that inhibits platelet derived growth factor (PDGF), autophosphorylation and PDGF-induced mitogenesis in fibroblast. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1837] "An enantiomer of tyrosine kinase inhibitor that inhibits epidermal growth factor receptor kinase autophosphorylation and phosphorylation of the poly-GAT. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1838] "A protein tyrosine kinase inhibitor that blocks tumor necrosis factor alpha induced cytotoxicity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1839] "A member of the Tyrphostin family of tyrosine kinase inhibitors that inhibits signal transduction through platelet-derived growth factor receptor and selectively attenuates smooth muscle cell growth. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1840] "A member of the Tyrphostin family of tyrosine kinase inhibitors that selectively inhibits platelet-derived growth factor beta-receptor kinase and angiogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1841] "A protein tyrosine kinase inhibitor that competitively inhibits epidermal growth factor receptor kinase activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1842] "A protein tyrosine inhibitor that is used as a negative control for the inhibition of epidermal growth factor receptor tyrosine kinase activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1843] "An inactive agent that is used as a negative control for the inhibition of epidermal growth factor receptor tyrosine kinase activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1844] "The tartrate salt form of Ketanserin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1845] "A monoclonal antibody that selectively binds with KDR and blocks the vascular endothelial growth factor-induced endothelial cell proliferation and prevents angiogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1846] "A monoclonal antibody that inhibits binding of vascular endothelial growth factor to its receptor, thereby inhibiting angiogenesis and tumor growth. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1847] "A monoclonal antibody that may prevent the growth of blood vessels from surounding tissue to a solid tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1848] "Natural blood pigments that selectively localize in tissues with high rates of metabolism such as cancers and inflammation. They also selectively localize and generate reactive oxygen species that induce apoptosis. Current use: Diagnosis and treatment of both neoplastic and cardiovascular diseases. Have applications in X-ray radiation therapy, photodynamic therapy, for oncology, photoangioplasty, and the light-based treatment of age-related macular degeneration. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1849] "A novel oxime derivative of radicicol that destabilizes the hsp90 client proteins, such as erbB2, raf-1 and AKT, which are essential for tumor cell growth and survival. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1850] "A tyrphostin compound inhibiting receptor autophosphorylation by inhibiting protein tyrosine kinase and is used to study receptor function. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1851] "A humanized monoclonal antibody that recognizes carcinoembryonic antigen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1852] "A radioconjugate comprised of a Vitamin B12 compound, Diethylenetriaminepentaacetate Adenosylcobalamin, linked to Indium 111.  Since tumors require a greater degree of this vitamin, In 111 might be useful in distinguishing malignant cells from non-malignant cells.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1853] "An orally-active synthetic hydroxamic acid derivative with potential antineoplastic activity.  MMI270 inhibits a broad spectrum of matrix metalloproteinases (MMPs) (specifically MMP-1, 2, 3, 9, and 13), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.  This agent may also downregulate lymphangiogenesis, resulting in decreased lymphatic system-related metastasis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1854] "A synthetic analogue of fungal protein that inhibits endothelial cell growth and angiogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1855] "A 16 kD N-terminal fragment of prolactin formed endogenously by cleavage of intact prolactin.  Possessing anti-angiogenic properties, prolactin 16-kD fragment inhibits the pro-angiogenic effects of basal fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) on endothelial cell proliferation, migration, and capillary organization.  This agent also induces caspase-mediated endothelial cell apoptosis and upregulates the expression of plasminogen activator inhibitor-1 (PAI-1); PAI-1 inhibits the activity of urokinase, an enzyme essential to angiogenesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                       
 [1856] "An amide analogue of Trichostatin A studied for potential antineoplastic activity.  A-65 inhibits zinc-dependent histone deacetylase, inducing terminal cell differentiation and anti-angiogenic activity.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1857] "A synthetic cytotoxic small molecule that binds to tubulin.  Bound to tubulin, D 24851 inhibits tubulin polymerization, cell cycle progression at the G2/M phase and, consequently, tumor cell growth.  This agent has been shown to be active against multi-drug resistant tumors. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1858] "A group of angiogenesis inhibitors that act by blocking the action of alpha(v)beta integrins.  An alpha(v) beta integrin inhibitor blocks the activity of an endothelial cell-surface expressed alpha(v)integrin, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1859] "A cytotoxin that interacts with microtubules and inhibits mitosis causing tumor cell death. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1860] "The cephalostatins comprise a family of more than 30 trisdecacyclic bissteroidal pyrazines with extreme cytotoxicity against human tumors, isolated from the African marine worm Cephalodiscus gilchristi. The mechanism of action of these compounds remains unknown. Beside a steroidal platform, critical features implicated in the pharmacophore include a set of covalently linked polar and nonpolar domains and the spiroketals. It was shown that cephalostatin 1 induces a novel pathway of receptor-independent apoptosis that selectively uses Smac/DIABLO (second mitochondria-derived activator of caspases/direct inhibitor of apoptosis-binding protein with a low isoelectric point) as a mitochondrial signaling molecule. Apoptosis was found to be dependent on caspase activity because the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone blocks cephalostatin 1-mediated DNA fragmentation. (NCI)"                                              
 [1861] "An ozonide of Terpene designed to oxidize tumor cells and control metastasis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1862] "A purified Keyhole Limpet Hemocyanin, a potent antigenic protein capable of eliciting both humoral and cellular immune responses against tumor cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1863] "A vaccine composed of killed glioma cancer cells from another patient for use in immunotherapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1864] "The N-substituted benzamide metoclopramide, a potential radiosensitizer, which inhibits DNA repair and induces apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1865] "A cell-based vaccine targets tumors expressing the HER2/neu marker.  HER-2/neu is a growth factor receptor, and its overexpression has been associated with a number of cancers including breast, ovarian, colon and lung cancers.  APC8024 comprise of autologous antigen-presenting peripheral blood mononuclear cells (APCs) that have been exposed to HER2/neu protein and can be administered to the patient.  These cells may stimulate an antitumor T-cell response to cancer cells expressing HER2/neu. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1866] "A monoclonal antibody directed against fibroblast activation protein, alpha."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1867] "A synthetic 16mer mimic of MUC-1."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1868] "A cancer vaccine comprised of an epitope from the Carcinoembryonic Antigen obtained from cancer cells that can stimulate an immune response against tumor cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1869] "A monoclonal antibody that recognizes the 3A1-antigen which is expressed on human T lymphocytes. Current Use: Marker for T cell neoplasms. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1870] "An orally-active synthetic aromatic retinoic acid agent with potential antineoplastic and chemopreventive activities.  LGD 1550 selectively binds to all three retinoic acid receptors (RAR-alpha, RAR-beta, and RAR-gamma), resulting in alterations in the expression of genes responsible for cell differentiation and proliferation.  This agent also acts as an inhibitor of activator protein 1 (AP-1), a protein that mediates trophic responses and malignant transformation.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1871] "A vaccine directed against Human Papillomavirus Type 11 that causes majority of the genital warts and anogenital cancers. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1872] "A carbohydrate-based compound that inhibits lectin and disrupts the cellular recognition processes identified in cancer and metastasis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1873] "An orally-active synthetic hydrochloride salt form of swainsonine, an inhibitor of Golgi alpha-mannosidase II.  Tridolgosir inhibits formation of carbohydrate structures affecting cell-cell adhesion, resulting in decreases in tumor growth or metastasis.  This agent also stimulates the immune system. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1874] "A human monoclonal antibody that targets the cytokeratin tumor-associated antigen and is used for the detection of recurrence and/or metastases of carcinoma of the colon or rectum. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1875] "A vaccine composed of tumor-associated antigen, mutant K-ras, which produces both a cytotoxic and helper T cell response to challenge tumor cells expressing the relevant K-ras oncogene. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1876] "A vaccine that contains the GM2 and GD2 antigens separately coupled to the carrier protein Keyhole Limpet Hemocyanin and mixed with QS-21 adjuvant (an immune system stimulant), designed to stimulate a patient's immune system to control or eradicate residual cancer cells after surgery, radiation or chemotherapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1877] "A nitrogen mustard compound that cross-links with DNA, causing inhibition of DNA synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1878] "A nitrogen mustard derivative that cross-links with DNA, causing inhibition of DNA synthesis. It may be used to treat certain cancers, but may cause a higher incidence of leukaemia and a dose-related incidence of lung tumors in animals. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1879] "A nitrogen mustard compound that cross-links with DNA, causing inhibition of DNA synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1880] "An aziridine alkylating agent that cross-links with DNA, causing inhibition of DNA synthesis. It has been used as a chemosterilant. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1881] "A monoclonal antibody that targets CD20, a B-cell-specific cell surface protein expressed on mature B lymphocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1882] "A folate analog that interferes with RNA, DNA, and protein synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1884] "Polyamine analogues that inhibit the synthesis or stimulate the catabolism of polyamines, intracellular compounds that are critical in cell growth and death pathways. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1885] "Antitumor agents that are activated by biological reduction and have selective efficacy against hypoxic solid tumors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1886] "A group of vitamin B9 derivatives that act as precursors, cofactor of enzymes and inhibitors involved in various biosynthesis of amino acids and, proteins and nucleic acid components. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1887] "Agents administered before, with, or after cancer therapy to reduce or prevent damage or toxicity to the heart. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1888] "Agents administered before, with, or after cancer therapy to reduce or prevent damage or toxicity to the normal cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1889] "Agents administered before, with, or after cancer therapy to reduce or prevent damage or toxicity to the liver. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1890] "Agents administered before, with, or after cancer therapy to reduce or prevent damage or toxicity to the urinary tract. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1891] "Compounds that inhibits the hypermethylation of DNA in malignant cells, restoring suppressor gene expression and re-establish controlled growth and differentiation of cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1892] "The N-alkylated analogue of the anthracycline antineoplastic antibiotic daunomycin.  N,N-Dibenzyl Daunomycin interacts with topoisomerase II, thereby inhibiting DNA replication and repair and promoting DNA fragmentation.  This agent is less cardiotoxic than daunomycin. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1893] "An agent that inhibits Dihydropyrimidine Dehydrogenase, a rate-limiting enzyme in the catabolism of 5-Fluorouracil (5-FU), blocking degradation of orally administered 5-FU and increasing bioavailability. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1894] "Agents that inhibit Inosine 5'-Phosphate Dehydrogenase, an regulatory enzyme of guanosine triphosphate biosynthesis, causing possible inhibition of cell proliferation and malignancy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1895] "Substances that block Inosine Monophosphate Dehydrogenase, a key enzyme involved in the biosynthesis of guanine nucleotides that regulate cell proliferation and differentiation, and has application in anti-cancer and immunosuppressive therapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1896] "Substances that inhibit ornithine decarboxylase, the first and rate-limiting enzyme that catalyzes the conversion of Ornithine to Putrescine that may affect cellular growth, differentiation, transformation, and apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1897] "Substances that inhibit a subgroup of protein kinase that catalyze certain cell protein phosphorylation reactions involved in inflammation, mitogenesis, and differentiation of cells and have application in cancer treatment and prevention. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1898] "Agents that inhibit S-Adenosyl-Methionine Decarboxylase, an enzyme involved in the biosynthesis of the polyamines, spermidine, and spermine, and are being developed as potential antitumor and/or antiparasitic agents. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1899] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1900] "Agents that inhibit gonadotropin releasing hormone, a key regulator of sex hormones involved in hormone dependent cancers. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1901] "A radioimmunoconjugate comprised of ethyl esters of poppy seed oil labelled with Iodine 131 for use as diagnostic aid and anticancer agent. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1902] "Agents that dilate blood vessels, loosen tight junctions and selectively deliver entrapped agents into tumor cells by receptor interaction. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1903] "An anti-HIV protease inhibitor"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1904] "A combination anti-HIV protease inhibitor from Abbott Laboratories.  Brand name is Kaletra."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1905] "Telomerase RNA component is the ribonucleic acid subunit of telomerase.  Telomerase uses the species-specific RNA sequences as the templates to synthesize GC-rich strand of telomeres, chromosome ends."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1906] "Cloning vector derived from the canarypox virus.  Similar to vaccinia virus vectors but elicit greater response in vaccinia-immune individuals.  Often used to express foreign genes in mammalian cells as a component of a vaccine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1907] "Agents administered before, with, or after cancer therapy to reduce or prevent damage or toxicity to the kidney. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1908] "Antineoplastic vaccine being developed against liver cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1909] "A bacterial cell wall mimetic.  It is a potent inducer of cytokines and is beginning Phase II trials in combination with chemotherapy for patients with non-small cell lung cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1910] "A liposomal formulation of the ether lipid 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine with potential antineoplastic activity.  TLC ELL-12 induces tumor cell apoptosis via mitochondria- and caspase-mediated mechanisms.  Liposomal encapsulation reduces the free agent's hemolytic toxicity.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1911] "A radioimmunoconjugate comprised of a monoclonal antibody, Lym-1,directed against HLA-Dr10 protein, a cell surface marker present on over 80% of lymphoma cells, labelled with Iodine 131. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1912] "A liposomal formulation of Vincristine designed to reduce toxicity and improve efficacy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1913] "An anti-HIV drug developed to inhibit the fusion of HIV with host cells, preventing the virus from entering cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1914] "A monoclonal antibody which recognizes the heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1, a potential epithelial marker in the detection of early lung cancer, on cell surfaces. This protein is responsible for posttranscriptional regulation of gene expression by capping, splicing, polyadenylation, and cytoplasmic transport of mRNAs. Its detection in bronchial lavage specimens was shown to predict predicts the presence of a neoplasm with 96% sensitivity and 82% specificity earlier than routine chest X rays or sputum cytology. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1915] "A class of antibiotics related to the anthracycline antineoplastic antibiotics.  The anthrapyrazole antibiotics intercalate into DNA and interact with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  These agents may also block cell cycle division.  In the presence of electron donors, some anthrapyrazole antibiotics cause single-strand breaks in DNA via photosensitization by visible light.  These agents are less cardiotoxic than doxorubicin.  (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1916] "A combination of 3 fluorescent-tagged monoclonal antibodies.  Recently licensed for screening of bladder cancer recurrence by urine test."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1917] "A group of antibiotics that targets DNA topoisomerase IV.  All quinolone derivatives belong to topo IV inhibitors.  The other target of these substances is bacterial gyrase.  Mutations in the quinolone resistance-determining region (QRDR) of subunits of both topo IV and gyrase confer resistance to single-step mutants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1918] "Alkylating agents with non-specific classification based on mechanism of action, therapeutic use, or chemical properties. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1919] "A group of unrelated agents that are not members of other antineoplastic antibiotic subcategories. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1920] "Biologic response modifiers with non-specific classification based on mechanism of action, therapeutic use, or chemical properties. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1921] "Chemoprotective agents with non-specific classification based on mechanism of action, therapeutic use, or chemical properties. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1922] "A blistering agent primarily containing sulfur and chlorine groups that alkylate with DNA to form DNA crosslinks, causing inhibition of DNA synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1923] "Antineoplastic agents that either covalently or noncovalently bind to the minor groove of DNA, causing inhibition of DNA synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1924] "Agents that selectively bind to estrogen receptors on breast cancer cells and stop estrogen-dependent cell proliferation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1925] "A class of agents that interfere with the intracellular glycoprotein glycosylation pathway.  Intracellular glycosylation of glycoproteins is involved in many cellular processes, including lymphocyte trafficking, immune cell stimulation, embryogenesis, and cancer metastasis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1926] "Chemotherapy agents with non-specific classification based on mechanism of action, therapeutic use, or chemical properties. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1927] "A class of agents that inhibit Golgi alpha-mannosidase II, a key enzyme involved in the protein glycosylation pathway.  These agents inhibit formation of carbohydrate structures that affect cell-cell adhesion, resulting in decreases in tumor growth and metastasis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1928] "Substances that inhibit lectin, a protein that binds carbohydrate on cell surfaces and causes cell agglutination. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1929] "Compounds that contain Ozone, a highly active oxidizing agent that have application in the treatment of bacterial and viral infections, cancer diagnosis, treatment, and evaluation of disease progression. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1930] "A class of agents that either induce or inhibit the differentiation or maturation of cells, specifically neoplastic cells, resulting in decreases in tumor growth and metastasis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1931] "A human immunoglobulin M class monoclonal antibody that recognizes a 30- to 45-kilo dalton intracellular antigen expressed in colorectal cancer cells and is being developed for applications in Antibody-Targeted Immunotherapy of cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1932] "Compounds comprised of a radioactive agent linked to a pharmacological substance to be used to prevent, diagnose, or treat various diseases, including cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1933] "A radioactive iodide salt that distributes mainly within the extracellular body fluid and selectively concentrates in certain organ tissues, including the thyroid gland. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1934] "A radioactive phosphate salt that distributes readily into intra and extracellular compartments and accumulates in rapidly dividing cancer cells leading to cell death. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1935] "Substances that inhibit the enzyme cGMP Phosphodiesterase leading to cGMP-dependent protein kinase activation, resulting in vasodilation and induction of apoptosis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1936] "Vesicant compounds originally used as chemical warfare agents. At high temperatures, is in vapor form and readily absorbed through the skin, eyes, airway, and GI tract.  It reacts with DNA, RNA, and proteins, compromising normal cell function.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1937] "An agent when activated is converted into an active mustard alkylating agent at the tumor site, causing DNA cross-linking.  These compounds may be used in antibody-directed enzyme prodrug therapy (ADEPT).(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1938] "Substances that inhibit gamma-Glutamylcysteine Synthetase, a rate-limiting enzyme in glutathione (GSH) biosynthesis, causing possible sensitization of tumor cells to alkylating agents, redox agents, and radiotherapy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1939] "Substances that inhibits differentiation of cells.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1940] "Substances that antagonize bombesin, an endogenous neurotransmitter found in many animals, and affect smooth muscle, gastrin secretion, and renal function.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1941] "Substances that inhibit Cytidine Triphosphate Synthetase, resulting in inhibition of de novo purine biosynthesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1942] "Substances that inhibit 06-Alkylguanine-DNA Alkyltransferase, a DNA repair enzyme, and interferes with the enzymes ability to remove alkyl adducts from DNA.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1943] "Substances that inhibit Cytidine Deaminase, an enzyme that catalyzes the deamination of cytosine, preventing deamination of different cytosine nucleoside analogs.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1944] "Substances that demonstrate efficacy in treating tumor induced hypercalcemia.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1945] "Substances that inhibit Glutathione Transferase, enzymes involved with cellular defense, and may inhibit drug resistance in cancer cells.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1946] "For non-invasive detection, Protease-Activated Near-Infrared Fluorescent Probes are used for in vivo Imaging of tumors in Mice."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1947] "Substances that stimulate the immune system.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1948] "Agents given to augment or stimulate a primary therapy or alleviate adverse effects caused by the primary therapy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1949] "Adjuvant used in chemotherapy that acts by stimulating the immune system.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1950] "Adjuvants used in surgical procedures.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1951] "A substance that inhibits the growth, migration, and proliferation of endothelial cells and/or induces endothelial cell apoptosis, resulting in the inhibition of angiogenesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1952] "A class of angiogenesis inhibitors that act by blocking the action of endothelial integrins.  An endothelial-specific integrin/survival signaling inhibitor binds to and blocks the activity of endothelial-specific integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1953] "A class of agents that act by inhibiting angiogenesis via mechanisms of action that are different from those of other defined classes of angiogenesis inhibitors.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1954] "Antimetabolites with non-specific mechanisms of action.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1955] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1956] "Substances that inhibit the action of Protein Kinase A, causing disruption of a protein phosphorylation cascade in certain signal transduction pathways.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1957] "Substances that inhibit Mitogen-Activated Protein Kinase, enzymes involved with signal transduction, and may inhibit cell proliferation.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1958] "Substances that inhibit Ribonucleotide Reductase, an enzyme converting ribonucleoside diphosphates to deoxyribonucleotide diphosphate precursors for de novo DNA synthesis, causing inhibition of DNA synthesis and cell growth.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [1959] "Substances that inhibit Purine Nucleoside Phosphorylase, an enzyme involved in the purine salvage pathway that metabolizes inosine and guanosine to hypoxanthine, increasing deoxyguanosine triphosphate, causing inhibition of DNA synthesis and cell growth.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1960] "Substances that inhibit Phosphatidylinositide 3-Kinase, an enzyme involved in many signalling pathways, and may affect many cellular functions, including mitogenesis, differentiation and apoptosis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1961] "Substances that inhibit Dihydrofolate Reductase interfering with the conversion of Dihydrofolate to Tetrahydrofolate, causing inhibition of nucleotide biosynthesis and protein synthesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [1962] "Substances that inhibit Palmitoyl Thioesterase, an enzyme that removes palmitate from certain cysteine residues in proteins.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1963] "Substances that inhibit Tyrosine Hydroxylase, an enzyme that catalyzes the conversion of tyrosine to dihydroxyphenylalanine, causing inhibition of catacholamine synthesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1964] "A class of spirocycloporpylhexadienone-containing antineoplastic antibiotics synthetically derived or isolated from various Streptomyces bacterial species.  Duocarmycin antibiotics alkylate DNA by binding to adenine-thymine (A-T)- rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1965] "Substances that inhibit Adenosine Deaminase, an enzyme involved with purine metabolism.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1966] "Substances that inhibit Glutamine Amidotransferase, an enzyme involved with de novo purine synthesis, resulting in inhibition of DNA synthesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1967] "Substances that inhibit Protein Phosphatase, an enzyme that removes serine or threonine phosphate groups from phosphoproteins, and may control cell proliferation.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1968] "Substances that inhibit Proteasome, a multicatalytic cellular structure responsible for ATP-dependent proteolysis, and may induce apoptosis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1969] "Agents that bind covalently or non-covalently in the major or minor groove of DNA and can disrupt DNA replication.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [1970] "Agents that bind to the major groove of DNA, interfering with DNA replication.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1971] "Agents forming adducts with DNA, causing DNA damage and possible mutagenesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [1972] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1973] "Second generation of antisense agents with segments of modified phosphorothioate oligonucleotides. The most extensively studied and used agents contain 2'-substituted modifications, such as 2'-O-methyl. In animal models, such modifications were associated with improved in vivo stability, oral bioavailability, and markedly decreased concentration-related adverse events that were common for the first generation of oligonucleotides and have been attributed to sequence-independent and sequence-specific effects. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1974] "A combination of two or more anti-infective agents in a single product to increase the products effectiveness.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1975] "Substances that inhibit Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase, involved with signal transduction pathways, and may be useful in treating tumors that over express EGFR.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1976] "Substances that inhibit Adenylosuccinate Synthetase, an enzyme involved in purine metabolism, and interferes with DNA, RNA, and ATP biosynthesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1977] "Substances that inhibit Dihydroorotate Dehydrogenase, an enzyme involved in pyrimidine synthesis, and interferes with DNA and RNA synthesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [1978] "Substances that inhibit Orotidylate Decarboxylase, an enzyme involved in pyrimidine synthesis, and interferes with DNA and RNA synthesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1979] "A dimer consisting of two adjacent pyrimidines covalently jointed by a cyclobutane ring, inhibiting DNA replication.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1980] "Agents used to transport genes or genetic material to a target tissue, including viruses, liposomal encapsulation, direct naked DNA injection, or molecular conjugates.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1981] "A type of virus used in cancer therapy.  The virus is changed in the laboratory and cannot cause disease. Viral vectors produce tumor antigens (proteins found on a tumor cell) and can stimulate an antitumor immune response in the body.  Viral vectors may also be used to carry genes that can change cancer cells back to normal cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1982] "Non-viral gene transduction agents used to transfer genes or genetic materials, such as bacterial and lipid complexes.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1983] "A gene therapy agent complex composed of a viral or non-viral gene transduction agent and gene or genetic material.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [1984] "A gene-vector complex composed of a gene or genetic material and a viral gene transduction agent.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [1985] "A gene-vector complex composed of a gene or genetic material and a non-viral gene transduction agent.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1986] "A gene transferred via a vector to a target tissue for use in Gene Therapy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [1987] "A receptor-targeted complex comprised of a truncated toxin fused to a hormone, growth factor, or immunologic agent (i.e. antibody) that binds to the tumor cell allowing the toxin to kill the cell following internalization.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1988] "Substances that antagonize vasopressin, causing, disruption of extracellular fluid volume regulation, vasodilation, and decreased blood pressure and vascular resistance.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [1989] "A predominantly female hormone derived from cholesterol belonging to the family of Steroid Hormones and is responsible for maintaining the health of reproductive tissues, breast, skin, and brain.  By-products of estrogen metabolism are thought to cause breast and prostate cancer.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1990] "Estrogens that are not steroids, but have a structural configuration resembling steroids and may mimic steroidal estrogen effect or bind to estrogen receptors.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [1991] "Releasing and inhibiting hormones secreted by the neurosecretory neurons of the hypothalamus binding to the receptors of the anterior pituitary cells and modulating the release of hormones the pituitary secretes.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [1992] "Substances that inhibit 3-Hydroxysteroid Dehydrogenase, an enzyme involved with the biosynthesis of steroid hormones, causing inhibition of steroid hormone synthesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1993] "Agents that inhibit Cyclin-dependent Kinase, enzymes that regulate cell cycle progression, and may promote differentiation, induce apoptosis, and inhibit angiogenesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1994] "A sulfonylurea compound containing aryl groups developed originally as a herbicide and has exhibited antitumor activity.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [1995] "A fusion protein of clotting factor VII with the Fc portion of an IgG1 antibody.  In the lab it can target to the blood vessels of solid tumors and initiate an immune response that results in the destruction of the blood vessel and death of the tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [1996] "A class of ether-linked lysophosphatidylcholines with potential antineoplastic activity.  Exhibiting anti-proliferative and immunomodulatory properties, alkyl-phosphocholine compounds modulate cell membrane permeability, phospholipid metabolism, and intracellular growth signal transduction pathways and induce cytotoxic macrophages, cell differentiation, and apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [1997] "A family of drugs that may prevent the ability of cancer cells to multiply quickly and invade other tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [1998] "The intoxicating beverage, ethanol."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [1999] "21- and 22-nucleotide double-stranded RNAs.  These are the mediators of a sequence-specific messenger RNA degradation process known as RNA interference.  They are generated by ribonuclease III cleavage from longer dsRNAs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2000] "TRIad of COstimulatory Molecules (B7-1, ICAM-1 and LFA-3).  An immunostimulant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2001] "A humanized monoclonal antibody that inhibits HER receptor dimerization."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2002] "A synthetic compound targeting growth signaling and angiogenesis .  BAY 43-9006 blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, BAY 43-9006 inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2003] "A MUCI peptide liposomal vaccine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2004] "Agents that prevent or impair tumor metastasis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2005] "Agents that prevent metastasis by interfering with the aggregation of tumor cells.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2006] "A drug that is not an opioid.  Examples include acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDS), such as aspirin and ibuprofen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2007] "Drugs used in combination with other pain drugs to assist or enhance their action."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2008] "Agents used in Boron Neutron Capture Therapy, a type of radiotherapy, as boron (boron-10) carriers.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2009] "Substances that inhibit mTOR, a protein kinase involved in growth related translation and transcription."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2010] "A benzamide derivative being studied for potential antineoplastic activity.  Acetyldinaline inhibits histone deacetylation, leading to inhibition of cell proliferation, induction of differentiation, and apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2011] "Acridine carboxamide. A substance that is being studied as an anticancer drug. It belongs to the family of drugs called topoisomerase inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2012] "A gene-viral vector complex comprised of an adenovirus vector and B7-1 gene targeting the CD80 antigen.  Adenovirus B7-1 is used as a component in antineoplastic vaccines to elicit a cytotoxic T-cell response.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2013] "A multivalent antineoplastic vaccine comprised of the bcr-abl oncogene breakpoint fusion peptide that elicits a bcr-abl specific T-cell immune response.  (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2014] "A substance that is being studied for its ability to decrease the side effects of interleukin-2 (IL-2)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2015] "An antibody with potential antineoplastic activity. Specific for both the high-affinity immunoglobulin G (IgG) receptor CD64 and epidermal growth factor receptor (EGFR), bispecific antibody MDX447 may enhance cellular immune responses against EGFR positive cells, resulting in increased tumor cell lysis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2016] "A boron carrier used in Boron Neutron Capture Therapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2017] "A monoclonal antibody used in the preparation Indium In 111 Capromab Pendetide as a diagnostic imaging agent for prostate cancer.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2018] "A drug that is similar but not identical to thalidomide and is being studied as an anticancer drug.  It belongs to the family of drugs called angiogenesis inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2019] "A nonionic block copolymer adjuvant used to enhance viral or non-viral polynucleotide delivery in gene therapy vaccines."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2020] "A vaccine comprised of a MAGE-3 peptide and PADRE 965.10, a vaccine adjuvant, that may elicit a cytotoxic T-cell response.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2021] "A liposome-encapsulated form of the citrate salt of the anthracycline antineoplastic antibiotic daunorubicin.  Liposomal delivery of doxorubicin citrate improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects.  Daunorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2022] "A vaccine comprised of autologous dendritic cells pulsed with Mart-1 (melanoma antigen recognized by T-cells) and gp100 melanoma antigens to elicit T-cell immune response.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2023] "A vaccine comprised of autologous dendritic cells pulsed with HER2/neu intracellular domain protein to induce a T-cell response.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2024] "A synthetic derivative of imidazole with potent antineoplastic properties.  Imidazole mustard alkylates DNA, preferentially at guanine residues, resulting in DNA interstrand crosslinks and inhibition of DNA replication and RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2025] "A radioimmunoconjugate comprised of LL2, an anti-CD22 pan-B-cell monoclonal antibody, labeled with Indium 111 for use in Radioimmunotherapy as an imaging agent.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2026] "A radioimmunoconjugate comprised of Lym-1, a monoclonal antibody that binds to the HLA-DR-encoded histocompatibility antigen, labeled with Indium 111 for use in Radioimmunotherapy as an imaging agent. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2027] "A radioimmunoconjugate comprised of MN-14, an anti-Carcinoembryonic Antigen (CEA) monoclonal antibody, labeled with Indium 111 for use in Radioimmunotherapy as an imaging agent. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2028] "A highly purified alpha interferon produced by a human lymphoid cell line.  Interferon alpha-n1 consists of multiple alpha interferon subtypes, at least two of which are glycosylated.  In contrast, recombinant alpha interferons are individual non-glycosylated proteins produced from individual alpha interferon genes.  Alpha interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose proteins have antiviral, antiproliferative, anticancer, and immune-modulating effects. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2029] "A recombinant form of the natural Interferon beta that varies in the amino acid sequence and lacks the carbohydrate side chain. Clinical Use: Multiple Sclerosis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2030] "An Interleukin-12 transduction gene used in Gene Therapy to stimulate natural killer cells and promote maturation of T-cell lymphocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2031] "A radioimmunoconjugate comprised of TNT-1/B, a monoclonal antibody that binds to the necrotic core of tumors, labeled with Iodine 131 for use in Radioimmunotherapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2032] "Tumor associated antigen that is unique to lung cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2033] "A substance that is being studied for its ability to reverse resistance to chemotherapy.  Also called LY335979."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2034] "A carotenoid that gives fruits and vegetables their red color.  Lycopene acts as an antioxidant, free radical scavenger, and stimulates intercellular communication, improving regulation of cell growth. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2035] "A vaccine comprised of the monoclonal antibody 4B5, an anti-GD2 anti-idiotypic antibody, mimicking the GD2 antigen, causing an immune response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2036] "A humanized monoclonal antibody directed against 1D10, a polymorphic determinant on the HLA-DR beta chain that is expressed on normal and neoplastic B cells. Apolizumab induces complement-mediated cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and apoptosis of 1D10 antigen-positive B cells in vitro.  (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2037] "An Fc Receptor-nonbinding humanized anti-CD3 monoclonal antibody targeting T lymphocytes, causing immunosuppression and apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2038] "A chimeric murine-human anti-CD4 monoclonal antibody that down regulates T-helper-inducer function. Clinical Trails: Multiple Sclerosis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2039] "A quinolone derivative that inhibits p-glycoprotein, affecting transmembrane transport and modulating multidrug resistance. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2040] "A vaccine comprised of MUC-1 protein conjugated with Keyhole Limpet Haemocyanin (KLH) that induces both humoral and cellular responses targeting tumors expressing MUC-1. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2041] "An isothiocyanate found in cruciferous vegetables and may have chemopreventive properties by inducing apoptosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2042] "A polymeric conjugate comprised of Camptothecin, a topoisomerase I inhibitor, covalently conjugated to a copolymer backbone (MAG, methacryloylglycinamide) inducing DNA strand breaks, causing DNA replication inhibition and apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2043] "A vaccine consisting of PR1 peptide, a 9 amino-acid Human Leukocyte Antigen (HLA)-A2, restricted peptide derived from proteinase 3, that may elicit cytotoxic T lymphocyte immunity.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2044] "A vaccine comprised of autologous dendritic cells pulsed with mRNA-encoded Prostate Specific Antigen (PSA) that elicits PSA specific T-cell response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2045] "A recombinant vaccinia virus encoding the T-cell co-stimulatory molecule B7-1. Co-administration of recombinant vaccinia-B7.1 and a tumor-associated antigen in a cancer vaccine enhances tumor-associated antigen-specific T-cell responses. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2046] "A viral vector derived from the LN series of replication-defective retroviral vectors.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2047] "Anti-HIV-1 transduction genes, RevM10 (a dominant negative mutant of the HIV-1 Revtrans-activator protein) and HIV-1 PolAS (an antisense RNA complementary to human HIV-1 pol gene), that have an inhibitory effect on HIV-1 replication in T-cell lines. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2048] "An oil-water emulsion comprised of QS21 and 3D-MPL used as a vaccine adjuvant to improve T-helper cells and antibody response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2049] "A substance that is being studied as an anticancer drug."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2050] "3-aminopyridine-2-carboxaldehyde thiosemicarbazone. A substance that is being studied as an anticancer drug. It belongs to the family of drugs called ribonucleotide reductase inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2051] "A recombinant form of endogenous Tumor Necrosis Factor alpha.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2052] "A recombinant form of endogenous Tumor Necrosis Factor alpha made by Knoll Pharmaceuticals.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2053] "A recombinant form of endogenous Tumor Necrosis Factor alpha made by Genzyme Pharmaceuticals.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2054] "A substance that is being studied for its ability to overcome tumor-cell resistance to anticancer drugs.  It belongs to the family of drugs called anthranilic acid derivatives."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2055] "A radioimmunoconjugate comprised of Lym-1, a monoclonal antibody that binds to the HLA-DR-encoded histocompatibility antigen, labeled with Yttrium 90 having a pro-apoptotic effect on tumor cells expressing HLA-DR-encoded histocompatibility antigen. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2056] "A radioimmunoconjugate comprised of M195, a humanized monoclonal antibody reactive with the cell surface antigen CD33, labeled with Yttrium 90 having a pro-apoptotic effect on tumor cells expressing CD33 antigen. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2057] "A radioimmunoconjugate comprised of MN-14, an anti-Carcinoembryonic Antigen (CEA) monoclonal antibody, labeled with Yttrium 90 having a pro-apoptotic effect on tumor cells expressing CEA. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2058] "A folate analogue that inhibits Dihydrofolate Reductase, an enzyme involved with nucleic acid synthesis, interfering with RNA, DNA, and protein synthesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2059] "A recombinant form of the endogenous chemokine platelet factor 4 with potential antineoplastic activity.  As a heparin-binding tetramer, recombinant platelet factor 4 inhibits growth factor-stimulated endothelial cell proliferation, migration, and angiogenesis.  This agent may also directly inhibit the proliferation of some tumor cell types.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2060] "Topical Agents that exhibit cytotoxic activity.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2061] "A topical agent containing a DNA repair enzyme.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2062] "Substances that inhibit Amidophosphoribosyltransferase, an enzyme involved with purine synthesis, interfering with de novo purine synthesis, causing inhibition of DNA synthesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2063] "Substances that inhibit Estrogen Sulfotransferase, an enzyme that catalyzes the sulfoconjugation of estrogen, modulating systemic and local estrogen response.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2064] "Recombinant form of endogenous delta-chemokine family.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2065] "A pro-inflammatory delta chemokine with potential antineoplastic activity.  Fractalkine induces the adhesion and migration of T lymphocytes, monocytes and natural killer (NK) cells.  In lymphomas, this agent may promote cell-mediated lympholysis by recruiting activated NK cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2066] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2067] "Recombinant form of endogenous neurotrophic factors.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2068] "Recombinant forms of endogenous neuropoietic cytokines.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2069] "Recombinant forms of endogenous Heparin-binding Neurotrophic factors(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2070] "Recombinant form of endogenous Insulin-like Growth Factor 1 exhibiting mitogenic activity.  Clinical Use: Diabetes Mellitus and Amyotrophic Lateral Sclerosis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2071] "Recombinant form of endogenous Insulin-like Growth Factor II exhibiting mitogenic activity.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2072] "Hormones made from cholesterol and protein produced by the adrenal glands and regulate electrolyte balance, blood pressure, inflammation, blood sugar balance, and immune system control.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2073] "A synthetic form of endogenous Dehydroepiandrosterone, a steroid hormone involved in the synthesis of testosterone and estrogen.  It has been banned by the FDA in over-the-counter products."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2074] "Recombinant form of endogenous thymopoietin, a thymic hormone.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2075] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2076] "A pancreatic hormone consisting of 29 amino acids that causes increases in blood sugar levels by stimulating hepatic glycogenolysis and gluconeogenesis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2077] "A hormone synthesized in the hypothalamus and regulates the secretion of adrenocorticotropic hormone (ACTH).(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2078] "LH-RH.  A hormone that stimulates the production of sex hormones in men and women."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2079] "(IN-su-lin) A hormone made by the islet cells of the pancreas. Insulin controls the amount of sugar in the blood by moving it into the cells, where it can be used by the body for energy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2080] "Gastrin-releasing peptide (GRP) is the equivalent in mammals of the amphibian bombesin. Infusion of either GRP or bombesin increases plasma levels of gastrin, pancreatic polypeptide, glucagon, gastric inhibitory peptide, and insulin. It is widely distributed in the gastrointestinal tract and in the nervous system.  In normal adult mammal GRP is strictly a neuropeptides and functions in a neurotransmitter-like fashion. In the fetus, a larger form of GRP acts as a hormone and exerts growth factor-like activity on many organs, aiding in development."                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2081] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2082] "Follicle-Stimulating Hormone and Luteinizing Hormone excreted in the urine of post-menopausal women.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2083] "A sialoglycoprotein hormone secreted by the placenta and maintains the corpus luteum at the beginning of the gestation period.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2084] "Inhibins are peptide hormones, secreted by the follicular cells of the ovary and by the testis, that negatively regulate the synthesis and secretion of follicle stimulating hormone from the anterior pituitary.  The detection of serum inhibins has been implicated in association with reproductive disorders, including infertility and ovarian cancers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2085] "Both inhibin A and inhibin B are heterodimers consisting of an alpha subunit and a beta A or beta B subunit linked by disulphide bonds.  Both inhibins function as negative regulators for FSH synthesis and secretion.  Furthermore, serum concentrations of inhibins transit from inhibin B to inhibin A dominance during menstrual cycle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2086] "Inhibin B, consisting of an alpha subunit and a beta B subunit linked by disulphide bonds, is a heterodimer hormone produced by the follicle cells of the ovary and by the Sertoli and Ledig cells of testis.  Although other forms of inhibin also exist in men, inhibin B is the predominant form in the circulation in men."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2087] "Encoded by human PTMA Gene, 110-aa 12-kDa (precursor) highly acidic (54/111 residues) conserved Prothymosin Alpha may be linked covalently to a small RNA; may be involved in ultraviolet irradiation-induced apoptosis; contains N-terminal thymosin-alpha-1 (28-aa) sequence; and may mediate immune function and confer resistance to opportunistic infections. While PHAP promotes caspase-9 activation after apoptosome formation, PTMA inhibits apoptosome formation and caspase-9 activation; caspase-3 activator PETCM relieves PTMA inhibition of apoptosome formation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                             
 [2088] "A peptide hormone secreted by the anterior pituitary. It promotes the growth of the thyroid gland and stimulates the synthesis of thyroid hormones and the release of thyroxine by the thyroid gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2089] "Encoded by human CALCA Gene (Calcitonin Family), 32-aa 3.4-kD secreted Calcitonin polypeptide hormone is cleaved from a large polyprotein precursor synthesized by thyroid parafollicular 'C' cells. Opposite to the effect of PTH, Calcitonin induces a rapid drop in blood calcium and phosphate level by promoting bone incorporation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2090] "A hormone secreted by the anterior portion of the pituitary gland and regulates hormone, primarily cortisol, secreted by the adrenal gland.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2091] "A hormone secreted by the posterior portion of the pituitary gland and stimulates uterine smooth muscle contraction and lactation.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2092] "A hormone secreted by the thymus gland and effects T-lymphocyte differentiation and activation.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2093] "This protein is processed from a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin II, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. (LocusLink)"                                                           
 [2094] "A gonadotropin hormone synthesized by the anterior lobe of the pituitary and is essential for reproduction, stimulating estrogen and sperm production.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2095] "A gonadotropin hormone synthesized by the anterior lobe of the pituitary that stimulates synthesis and secretion of testosterone and estrogen, and ovulation of mature follicles on the ovary.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2096] "A peptide hormone secreted by the anterior lobe of the pituitary gland and regulates several physiologic processes, including growth and metabolism.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2097] "Hormones possessing the steroid ring system; e.g., androgens, estrogens, adrenocortical hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2098] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2099] "A natural steroid hormone produced in the adrenal gland. It can also be made in the laboratory.  Cortisone reduces swelling and can suppress immune responses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2100] "A hormone and neurotransmitter. Also called adrenaline."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2101] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2102] "One of three naturally occuring estrogens synthesized from androstenedione in the adrenal glands and peripheral tissues by aromatization and is the primary estrogen produced after menopause.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2103] "Estradiol (E2). beta-estradiol; 17 beta-estradiol; 1,3,5(10)-estratriene-3,17 beta-diol; the most potent naturally occurring estrogen in mammals, formed by the ovary, placenta, testis, and possibly the adrenal cortex; therapeutic indications for estradiol are those typical of an estrogen. alpha-Estradiol, (17 alpha-estradiol), exhibits considerably less biologic activity. Estradiol is used in the treatment of menstrual disorders, menopause problems, etc. SYN estrogenic hormone, oestradiol."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2104] "A hormone secreted in the uterus controlling ovum implantation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2105] "(pro-JES-ter-own) A female hormone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2106] "(AN-dro-jens) A family of hormones that promote the development and maintenance of male sex characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2107] "(tes-TOS-ter-own) A hormone that promotes the development and maintenance of male sex characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2108] "A steroid hormone synthesized by the adrenal glands and the gonads from either 17-alpha-hydroxyprogesterone or dehydroepiandrosterone and is a precursor of testosterone.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2109] "A synthetic testosterone derivative that inhibits steroid aromatase and blocks synthesis of estrogen from testosterone or androstenedione. Clinical Use: Breast Cancer.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2110] "A hormone synthesized and secreted by the thyroid gland containing four iodine atoms and is converted to triiodothyronine (T3) in the body, influencing metabolism and organ function.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2111] "A thyroid hormone containing 3 iodine atoms generally synthesized from levothyroxine, and has greater biological activity.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2112] "(THIGH-roe-GLOB-yu-lin)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2113] "An anti-CD7 immunotoxin comprised of the monoclonal antibody WT1 and the ricin-a chain toxin, causing decreased T-lymphocyte production, natural killer cell activity, and protein synthesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2114] "A recombinant replication-deficient serotype 5 adenovirus. Containing an expression cassette consisting of the human cytomegalovirus (CMV) promoter and the simian virus 40 (SV40) polyadenylation signal, Ad5CMV is used as a transfer vector for inserting genes of interest into target cells for expression. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2115] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2116] "An alkylsulfonate alkylating agent that cross-links with DNA, causing inhibition of DNA synthesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2117] "Glutamine and Asparagine depleting enzyme belonging to the family of tetrameric bacterial amidohydrolases and have antitumor activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2118] "A pegylated form of glutaminase-asparaginase developed to decrease immunogenicity.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2119] "A class of basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus.  Bleomycin antibiotics form complexes with iron that reduce molecular oxygen to superoxide (O2-) and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.  (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2120] "A derivative of the Canarypox Virus, ALVAC can infect mammalian cells but it can't replicate.  Thus, it produces a self-limiting infection which does not produce symptoms or harm the host.  When carrying foreign genes it will cause transient expression of protein."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2121] "A class of antineoplastic vaccines containing the vaccinia virus, originally used for immunization against smallpox, as a viral vector and immunogenic substance.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2122] "An immunotoxin composed of the hormone gastrin linked to diptheria toxin.  It is in phase 3 trials for the treatment of pancreatic cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2123] "Chemicals produced by glands in the body and circulated in the bloodstream. Hormones control the actions of certain cells or organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2124] "Adjuvant agents with non-specific classifications.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2125] "A class of food constituents, also known as fats and oils, that serve as a source of energy and essential fatty acids in animals. The major components of lipids are fatty acids, triglycerides, phospholipids, glycolipids, sphingolipids, steroids (cholesterol), and lipoproteins.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2126] "An over-the-counter alternative health supplement, of interest because of the lack of detectable cancer in sharks.  Shark cartilage appears to be a rich source of antiangiogenesis factors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2127] "Substances that inhibit 5-alpha-Reductase, an enzyme that metabolizes testosterone to dihydrotestosterone, and can reduce prostate size.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2128] "A triazene triepoxide alkylating agent. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2129] "A catecholamine hormone that functions as a neurotransmitter in the sympathetic nervous system, producing alpha-adrenergic (vasoconstriction) and beta(1)-adrenergic stimulation (increase myocardial contractility, heart rate, automaticity, and AV conduction), and beta(2)-adrenergic activity (peripheral vasodilation).(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2130] "Hormones synthesized in the cortex of the adrenal gland and consist of two subclasses, glucocorticoids (carbohydrate regulation) and mineralocorticoids (electrolyte regulation).(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2131] "A class of corticosteroid hormones that effect carbohydrate, fat, and protein metabolism and exhibit anti-inflammatory and immunosuppressive activity. The main glucocorticoid is Cortisol.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2132] "A class of corticosteroid hormones that maintains fluid and electrolyte balance. The main mineralocorticoid is Aldosterone.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2133] "A therapeutic analogue of an endogenous, platelet-specific protein that is a member of the alpha chemokine family.  Beta thromboglobulin may be used as a marker for platelet activation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2134] "A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 7 (FGF-7). Because it stimulates proliferation and differentiation in parenchymal epithelial cells of differentiated tissues, recombinant FGF-7 may be useful in the treatment of wounds and pathologies associated with dermal adnexae, liver, lungs and the gastrointestinal tract. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2135] "A vitamin being studied to increase the effect of radiation therapy on tumor cells. Also called niacinamide."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2136] "The sodium salt form of cefotaxime.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2137] "An immunotoxin comprised of an anti-CD7 antibody, HB-2, linked to Saporin, a toxin that inhibits protein synthesis, eliciting an antibody-dependent cellular immunity response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2138] "A class of immunotoxins targeting CD19, a common B-cell marker.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2139] "An immunotoxin comprised of a ribosome inhibitory plant toxin, Pokeweed Antiviral Protein (PAP), conjugated with a murine IgG1 anti-CD19 monoclonal antibody selectively targeting B-lineage progenitor cells, causing apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2140] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2141] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2142] "An anticancer drug that is a combination of a monoclonal antibody (RFB4) and an immunotoxin (dgA)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2143] "An immunotoxin comprised of a SMPT stabilized anti-CD22 murine monoclonal antibody, RFB4, linked with a deglycosylated A chain of ricin, a toxin, selectively targeting and poisoning CD22 expressing tumor cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2144] "Substances that inhibit Raf Kinase, an enzyme active in signal transduction of the Ras pathway, and may prevent tumor formation.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2145] "A histone deacetylase inhibitor that induces cell differentiation and apoptosis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2146] "A combination antibiotic containing Imipenem, a broad spectrum beta-lactam antibiotic, and Cilastatin Sodium, an agent that reduces metabolism of Imipenem by inhibiting dehydropeptidase, used in treating severe infections caused by multiresistant organisms.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2147] "A mycobacterial cell wall material and serves as an immunoadjuvant that induces both cell-mediated and humoral immunity.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2148] "A discontinued (U.S.) brand name combination product containing Prochlorperazine Maleate and Isopropamide Iodide that was used as an antiemetic agent.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2149] "A vaccine made of tumor antigens (proteins isolated from tumor cells)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2150] "A genetically engineered agent that is capable of binding to the HIV envelope protein (gp120) and may reduce the ability of HIV to enter the cell and reproduce. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2151] "A Cytosine Arabinoside derivative that inhibits pyrimidine synthesis, causing inhibition of DNA synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2152] "The sodium salt form of Camptothecin.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2153] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2154] "Recombinant forms of the naturally occuring hormones synthesized by the pituitary gland.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2155] "A mouse anti-GD3 ganglioside, a melanoma-associated ganglioside, monoclonal antibody. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2156] "Glycoproteins contained in epithelial mucous secretions that express Sialyl Tn obtained from Ovine submaxillary glands and may be used in Vaccine Therapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2157] "Oxygen that is at an atmospheric pressure higher than the pressure at sea level.  Breathing hyperbaric oxygen to enhance the effectiveness of radiation therapy is being studied."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2158] "A purine derivative with antineoplastic and anti-angiogenic properties.  6-methylmercaptopurine riboside (6-MMPR) inhibits amidophosphoribosyltransferase, the first committed step in de novo purine synthesis, and inhibits fibroblast growth factor-2 (FGF2)-induced cell proliferation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2159] "The disodium salt form of N-Phosphonacetyl-L-Aspartate (PALA).(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2160] "A natural liver metabolite and antioxidant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2161] "Substances that inhibit the biologic effects of the adrenal hormones by interfering with their synthesis, metabolism, or binding to their receptor sites.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2162] "Nonnarcotic agents that relieve pain and reduce fever.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2163] "A radioimmunoconjugate comprised of antibodies to ferritin, expressed by hepatocellular carcinoma, and labeled with Iodine 131. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2164] "An anti-T-cell monoclonal antibody used in Immunotherapy and Radioimmunodetection. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2165] "An immunotoxin; a ricin-containing toxin that can be targeted to specific cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2166] "Synthetic derivatives of the male hormone, androgen, that promote tissue growth by increasing the metabolic processes involved with protein synthesis and are used to promote weight gain in wasting diseases. They are used by bodybuilders and athletes to increase muscle mass, strength, and stamina.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2167] "Class of organic compounds that consist of urea and other compounds including Sulfonyl compounds and have application in pharmaceutical and agricultural preparation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2168] "A resin extracted from the root of the plant Podophyllum sp. Berberidaceae (mandrake), which contains numerous compounds, among which podophyllotoxin is the principal active component.  Podophyllin arrests mitosis in metaphase.  Podophyllotoxin offers advantages over podophyllin in terms of purity, stability and lack of systemic toxicity. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2169] "A broad spectrum antibiotic family derived from Streptomyces containing aminoglycosides that bind to bacterial ribosomes, inhibiting protein synthesis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2170] "Pharmacological agents which affect the function of the adrenal glands. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2171] "A drug regimen using Pefloxacin, a fluoroquinolone antibiotic, and Penicillin V, a penicillin antibiotic, that was studied for use as prophylaxis of bacterial infections in Granulocytopenic Cancer.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2172] "An antifolate derived from diaminopyrimidine with cytotoxic properties.  With a mechanism of action similar to that of methotrexate (MTX), m-azidopyrimethamine blocks tetrahydrofolate synthesis, resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. This agent is more lipophilic but less potent than MTX. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2173] "A methylating dacarbazine analogue inhibiting 06-alkylguanine-DNA alkyltransferase, a DNA repair protein, causing DNA cross-linkage and inhibition of DNA replication and repair. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2174] "A murine anti-ganglioside (GD2), a ganglioside overexpressed on malignant melanoma, neuroblastoma, and small cell carcinoma of the lung, monoclonal antibody. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2175] "An analogue of consensus interferon which contains an additional methionyl amino acid residue.  Consensus interferon (also known as interferon alfacon-1, rCon-IFN, and CIFN) is a genetically engineered synthetic interferon created from the most common amino acid sequences from the naturally occurring alpha interferons.  Alpha interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune-modulating effects. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2176] "A murine anti-ganglioside (GD2), a ganglioside overexpressed on malignant melanoma, neuroblastoma, and small cell carcinoma of the lung, monoclonal antibody. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2177] "A substance used to treat tumor cells for synthesis of a tumor-specific immunotherapeutic agent, ethylchorformate polymerized tumor protein, for use in Immunotherapy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2178] "A pan carcinoma murine monoclonal antibody that recognizes a membrane glycoprotein, L6 antigen, that is overexpressed on lung, breast, colon, and ovarian carcinomas. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2179] "A liposomal formulation of Interleukin-2 (IL-2) that facilitates targeted delivery of IL-2 to immune system cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2180] "Transforming growth factor alpha-Pseudomonas exotoxin-40 (TP40) is a hybrid fusion protein that selectively binds to cancer cells that express the epidermal growth factor receptor. TP40 is then internalized and kills these cells by virtue of its Pseudomonas exotoxin-derived domains."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2181] "Administration can activate monocyte cytotoxicity and cytokine production"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2182] "A substance used to stimulate the production of antibodies that fight certain cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2183] "A lysosomotropic agent taken up by cells and converted to pro-apoptotic metabolites that are membranolytic for cytotoxic T-cells, Natural Killer (NK) cells, and Lymphokine-activated Killer (LAK) cells.  Studies have treated donor cells ex-vivo with L-Leucyl-L-Leucine Methyl Ester (LLME) to test its ability to prevent Graft Versus Host Disease(GVHD)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2184] "A vinca alkaloid that inhibits mitosis by binding to microtubule protein, tubulin, ultimately inhibiting formation of mitotic spindles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2185] "A substance that is being studied for its ability to protect against the gastrointestinal side effects caused by fluorouracil.  It is a precursor of uridine, which is a component of RNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2186] "An anti-CD19 immunotoxin comprised of an anti-B4 monoclonal antibody linked with ricin, a toxin derived from the castor bean. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2187] "A dimeric fusion protein comprised of a recombinant form of the extracellular ligand-binding portion of the human 75-kilodalton tumor necrosis factor receptor linked to the Fc portion of human immunoglobulin G1 (IgG1).(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2188] "An anti-idiotypic monoclonal antibody that mimics GD3, a tumor antigen for use as an immune stimulant. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2189] "A recombinant fusion protein composed of the diphtheria toxin with the receptor-binding domain replaced by human epidermal growth factor (EGF).  When administered, EGF binds to the endothelial cell growth factor receptor, EGFR, which is upregulated in many solid tumors.  After binding to the EGF receptor, the agent is internalized by the cell, where the diphtheria toxin moiety exerts its cytotoxic effect, inhibiting protein synthesis through ADP-ribosylation of elongation factor 2. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2190] "A vaccine comprised of Tyrosinase, a tumor antigen, conjugated with Keyhole Limpet Hemocyanin (KLH), an immunogenic protein, for use in Immunotherapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2191] "A muramyl dipeptide family member, a potent immunomodulator. It is under development as a vaccine adjuvant. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2192] "Glycoprotein 100 (gp100) is a tumor specific antigen highly expressed in melanoma tumors with potential use in cancer vaccines."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2193] "An anti-CD22 pan-B-cell monoclonal antibody that is used in Immunotherapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2194] "The anticancer drug cytarabine formulated inside small particles of a synthetic lipid material called DepoFoam. This dosage form slowly releases the drug and provides a sustained action."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2195] "Daflon 500 is a phlebotonic drug and a vascular protecting agent.  It is reported to improve microcirculation in chronic venous insufficiency by improvement of venous tone, inhibition of prostaglandin synthesis, protection against free radicals, activation of the complement system, and increased lymphatic drainage. This results in reduced venous capacitance, distensibility, and emptying time; reduced capillary permeability; and increased capillary resistance. (Angiology 1994 Jun;45(6):419-2)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2196] "Substances that control the excessive secretion of sebum, the oily secretions from sweat glands.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2197] "A radioactive alkaline earth metal with atomic number of 88 that was used as an early radiation source for cancer treatment. It is also been reported to cause cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2198] "A transition metal with atomic number 79, atomic weight 196.96654, and symbol Au used in jewelry, electronics, and coins.  Certain salt forms are used to treat Rheumatoid Arthritis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2199] "Substances that are either used in or are by-products of the manufacturing process and are often ecological problems or health hazards.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2200] "Antibiotic agents with non-specific classifications.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2201] "Hematopoietic growth factors promote the development of blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2202] "A radioconjugate comprised of liothyronine, a synthetic thyroid hormone T3, labeled with Iodine 131.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2203] "Pan-DR epitope (PADRE) 965.10 is a helper peptide.  PADRE peptides have been shown the capacity to deliver help for antibody responses in vivo. They were also found to be able to provide significant helper T-cell activity in vivo.  Acts as an adjuvant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2204] "An intravenous formulation of tretinoin (vitamin A acid or all-trans retinoic acid) encased in liposomes that was developed to provide increased and prolonged levels of tretinoin compared to the oral formulation.  Tretinoin is a naturally occurring retinoic acid agent that binds to and activates retinoic acid receptors (RAR), thereby causing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of carcinogenesis.  Vitamin A acid also inhibits telomerase, leading to telomere shortening and eventual apoptosis of certain cancer cell types. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                        
 [2205] "A monoclonal antibody with potential antineoplastic activity.  Specific for both the immunoglobulin G (IgG) receptor CD16 and c-erbB-2, bispecific antibody 2B1 may enhance cellular immune responses against c-erbB-2-positive cells, resulting in increased tumor cell lysis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2206] "A vaccine comprised of a murine monoclonal antibody against ganglioside GD2 conjugated with Keyhole Limpet Hemocyanin (KLH) plus the immunological adjuvant QS-21.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2207] "A tumor-specific antigen used in the development of cancer vaccines."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2208] "The pamoate form of Octreotide that is a long-acting release formulation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2209] "A recombinant vaccinia virus; encodes HPV types 16 and 18, E6 and E7 proteins; used for immunotherapy of cervical cancer"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2210] "A drug that may protect healthy tissue from the toxic effects of anticancer drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2211] "A substance used as both a diagnostic agent and a boron carrier in Boron Neutron Capture Therapy.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2212] "A synthetic peptide (IMDQVPFSV) used to vaccinate patient with metastatic melanoma.  It is a modified gp209 (ITDQVPFSV) peptide, which is part of gp100 antigen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2213] "A protein/sugar compound made by some cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2214] "A topical lotion that contains the T4-bacteriophage endonuclease V enzyme within liposomes.  Applied topically, the enzyme can enter the cell nucleus, bind to pyrimidine dimers, and stimulate the cell's DNA repair system.  It is in trial as a treatment for xeroderma pigmentosum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2215] "The F(ab)2 fragment of the monoclonal antibody Me1-14 that recognizes the proteoglycan chondroitin sulfate-associated protein of gliomas and melanomas.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2216] "A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2217] "A growth factor antagonist that may stop tumor cells from growing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2218] "A polyamine analogue that exhibits antiproliferative activity and acts as an anti-diarrheal agent by delaying intestinal transit and enhancing fluid reabsorption. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2219] "A mixture of 15 different cytokines and biologic response modifiers (containing: IL-2, IL-1 beta, IFN-gamma, TNF-alpha, and GM-CSF, among others)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2220] "A nine amino acid peptide fragment of carcinoembryonic antigen (CEA), a protein that is overexpressed in several cancer cell types, including gastrointestinal, breast, and non-small cell lung. Autologous vaccination with activated autologous dendritic cells (DC) or peripheral blood mononuclear cells (PBMC) which have been exposed to CEA peptide 1 in vitro may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing CEA, thereby inhibiting tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2221] "Potassium salt of oxonic acid, an inhibitor of uricase (urate oxidase)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2222] "An agent that enhances the antitumor activity of fluoropyrimidines by inhibiting the enzyme Dihydropyrimidine Dehydrogenase, causing decreased degradation of the fluoropyrimidines.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2223] "The F(ab)2 fragment of monoclonal antibody MX35, an epithelial differentiation antigen, that exhibits reactivity with epithelial ovarian cancers.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2224] "Cartilage extracted from various parts of a cow and is proposed to stimulate the immune system and inhibit tumor cell growth.  It was used in the 1950s and 60s to enhance wound healing. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2225] "A peptide based vaccine consisting of amino acids 12 through 20 of the E7 gene of the Human Papilloma Virus type 16.  HPV-16 E7 12-20 peptide vaccine may elicit a specific CD8 T-cell response to the E7 oncogene protein, thereby inhibiting the abrogation of p53 and pRb function and thus prevent tumorigenesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2226] "E1A gene combined with lipids that serve as a means to deliver the E1A gene into the cancer cells. The combination of lipids and the E1A gene is called the E1A Lipid Complex."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2227] "A radioimmunoconjugate comprised of monoclonal antibody-170 labelled with technetium 99m. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2228] "A fluoronucleoside that inhibits pyrimidine synthesis, interfering with DNA synthesis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2229] "A drug that inhibits the growth of tumor cells that express the mutated p53 gene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2230] "A recombinant monoclonal antibody in which the heavy and light chain variable domains mimic a specific epitope of the tumor-associated protein carcinoembryonic antigen (CEA).  This agent is used as a cancer vaccine against tumors that express CEA. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2231] "A detoxified, nonspecific immunostimulant consisting of a combination of the active monophosphoryl lipid A component of lipopolysaccharide (LPS) isolated from the bacterium Salmonella minnesota combined with a residue of the cell wall of the bacterium Mycobacterium phlei. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2232] "A vaccine comprised of autologous dendritic cells pulsed with MART-1 (melanoma antigen recognized by T-cells) peptide targeting tumor cells expressing MART-1.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2233] "A vaccine comprised of autologous dendritic cells pulsed with G9-209-2m peptide, a modified epitope of the gp100 melanoma-associated antigen. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2234] "A vaccine comprised of HSV-tk-gene-modified PA-1-STK cells (tumor cells) that exhibits antitumor activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2235] "A vaccine comprised of irradiated autologous sarcoma cells transfected with a human sargramostim (Granulocyte Macrophage-Colony-Stimulating Factor) gene. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2236] "A vaccine comprised of irradiated autologous melanoma cells transfected with a human sargramostim (Granulocyte Macrophage-Colony-Stimulating Factor) gene. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2237] "A radioimmunoconjugate comprised of 3F8, a murine anti-GD2 ganglioside monoclonal antibody, labeled with Iodine 131 for use in Radioimmunotherapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2238] "A cancer vaccine based upon technology which uses heat shock proteins to activate cellular immune responses. Heat shock protein-peptide complexes isolated from individual tumors have been shown to elicit tumor immunity against the individual tumor but not unrelated tumors. The heat shock protein is not immunogenic, but acts as a carrier or chaperone of antigenic peptides, chaperoning a repertoire of cellular peptides for that particular tumor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2239] "A vaccine comprised of a recombinant vaccinia virus encoding the human Prostate Specific Antigen (PSA). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2240] "Environmental tobacco smoke. Smoke that comes from the burning of a tobacco product and smoke that is exhaled by smokers (second-hand smoke). Inhaling ETS is called involuntary or passive smoking."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2241] "A toxin linked to an anti-CD7 antibody."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2242] "A vaccine comprised of an anti-idiotype rat monoclonal antibody A1G4, that targets ganglioside GD2. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2243] "A non-viral vector gene complex comprised of a plasmid DNA encoding human Interleukin-2 (IL-2) complexed in a 5:1 ratio with a cationic lipid, 1,2-dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide/dioleyl-phosphatidyl-ethanolamine (DMRIE/DOPE), that facilitates the transfection of plasmid DNA, resulting in expression of a biologically active IL-2. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2244] "A vaccine comprised of a mutated Ras peptide corresponding to the mutation of the Ras proto-oncogene that is harbored in the tumor, to elicit an immune response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2245] "A vaccine comprised of autologous dendritic cells pulsed with mRNA-encoded Carcinoembryonic Antigen (CEA) targeting tumor cells expressing CEA. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2246] "A radioimmunoconjugate comprised of a monoclonal antibody that recognizes A33, a cell surface glycoprotein expressed in human colonic epithelium and colon cancer, labelled with Iodine 124.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2247] "A substance that is being studied as an anticancer drug.  It belongs to the family of drugs called recombinant chimeric proteins.  Also called NBI-3001."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2248] "A vaccine comprised of a recombinant canarypox virus encoding the human Interleukin-12 (IL-12) gene. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2249] "A drug being studied to make cancer cells less resistant to the effects of chemotherapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2250] "A monoclonal antibody directed against a protein (CD20) expressed on the surface of B-lymphocytes and radiolabeled with the radioisotope I 131 with potential antineoplastic activity.  Radioimmunotherapy using radiolabeled antibodies delivers radiation directly to neoplastic cells, decreasing the risk for systemic radiotoxicity. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2251] "A vaccine comprised of irradiated allogenic pancreatic tumor cells transfected with a human sargramostim (Granulocyte Macrophage-Colony-Stimulating Factor) gene. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2252] "An anti-idiotype monoclonal antibody that mimics an epitope of the human milk fat globule, an antigen expressed by breast cancer cells, used in Vaccine Therapy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2253] "A murine IgG anti-transferrin (Tf) receptor monoclonal antibody that interacts synergistically with other anti-Tf monoclonal antibodies to inhibit tumor growth. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2254] "A murine IgG anti-transferrin (Tf) receptor monoclonal antibody that interacts synergistically with other anti-Tf monoclonal antibodies to inhibit tumor growth. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2255] "A radioimmunoconjugate comprised of the chimeric monoclonal antibody G-250 that targets G250, a renal-cell carcinoma-associated antigen, labelled with Iodine 131 for use in Radioimmunotherapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2256] "A radioactive chemical being studied to treat bone pain associated with cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2257] "Adenovirus-derived vectors engineered to carry the p53 gene and produce p53 protein in deficient cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2258] "A colloidal dispersion formulation of 9-Aminocamptothecin, a Topoisomerase I inhibitor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2259] "A bivalent fusion protein consisting of disulfide-stabilized Fv fragments of an anti-HER2 (erbB2) monoclonal antibody (e23) and a truncated version of the M(r) 38 fragment of Pseudomonas exotoxin that lacks the toxin's cell binding domain. ERB-38 immunotoxin binds specifically to cells that overexpress HER2, the antigenic target of the monoclonal antibody; the exotoxin portion of the immunotoxin then lyses the cells bound by the antibody portion. . (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2260] "A chemically-modified tetracycline with potential antineoplastic activity.  COL-3 inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.  This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2261] "A recombinant form of the natural human Keratinocyte Growth Factor that has been shown to simulate proliferation, migration, and differentiation of a variety of epithelial cell types. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2262] "An antibody against carcinoembryonic antigen (CEA), a protein present on certain types of cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2263] "An oligonucleotide targeting the c-FOS gene, causing suppression of c-FOS protein expression.  c-FOS Antisense was in clinical trials for metastatic breast cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2264] "Cancer cells from an individual's own tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2265] "A quality of some drugs used in cancer treatment. Chemoprotective agents protect healthy tissue from the toxic effects of anticancer drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2266] "A hormone substance used in the treatment of some types of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2267] "A protein found on the surface of some cancers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2268] "(RAY-dee-o-AK-tiv EYE-uh-dine) A radioactive form of iodine, often used for imaging tests or as a treatment for cancer. For imaging tests, the patient takes a small amount of radioactive iodine by mouth, and it collects in the thyroid. A probe is used to scan the thyroid. For treatment, the patient takes a large dose of radioactive iodine, which kills thyroid cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2269] "RNA from a virus that is used to insert genetic material into cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2270] "A vaccine comprised of CD80-transfected allogenic breast cancer cells to induce T-cell response.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2271] "A vaccine comprised of MUC-2 antigen conjugated with Keyhole Limpet Hemocyanin (KLH). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2272] "A vaccine comprised of peptide 946, a gp100 peptide recognized by melanoma-specific cytotoxic T lymphocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2273] "A vaccine comprised of peptide 946, a gp100 peptide recognized by melanoma-specific cytotoxic T lymphocytes, conjugated with a modified T-helper epitope from tetanus toxoid. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2274] "A vaccine comprised of a modified T-cell epitope from tetanus toxoid. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2275] "A vaccine comprised of peptide 946, a gp100 peptide recognized by melanoma-specific cytotoxic T lymphocytes, conjugated with a modified T-helper epitope from tetanus toxoid and emulsified with QS21, a saponin vaccine adjuvant. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2276] "A humanized anti-epithelial cell adhesion molecule (17-1A epithelial antigen) monoclonal antibody. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2277] "A replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Ad5CMV-p53 induces tumor cells that have been transfected with the vector to produce wild-type p53, a tumor suppressor gene that is deleted or mutated in a significant number of cancers. In transfected tumor cells, the wild-type p-53 gene product exerts an antitumor effect by blocking cell cycle progression at the G1/S regulation point, activating DNA repair proteins in the presence of DNA damage, and initiating apoptosis when DNA damage is irreparable.  (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2278] "A fusion protein that contains a monoclonal antibody fragment linked to Pseudomonas exotoxin A.  LMB-9 immunotoxin attaches to tumor cells and the exotoxin inhibits protein synthesis by inactivating elongation factor 2. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2279] "A vaccine comprised of autologous dendritic cells pulsed with Carcinoembryonic antigen (CEA) peptide targeting tumor cells expressing CEA. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2280] "A vaccine comprised of a Tn(c) antigen conjugated with Keyhole Limpet Hemocyanin (KLH). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2281] "A colony-stimulating factor that stimulates the production of blood cells, especially platelets; it is given during chemotherapy to increase blood cell regeneration. Promegapoietin is a cytokine that belongs to the family of drugs called hematopoietic (blood-forming) agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2282] "A monoclonal antibody against the external domain of the Prostate Membrane Specific Antigen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2283] "A radioimmunoconjugate comprised of a monoclonal antibody that recognizes A33, a cell surface glycoprotein expressed in human colonic epithelium and colon cancer, labelled with Iodine 131. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2284] "A hapten used as an adjuvant to modify proteins in vaccine therapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2285] "A neuropeptide that mediates pain perception."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2286] "A substance (such as a radioisotope) used in imaging procedures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2287] "A synthetic luteinizing hormone-releasing hormone (LH-RH) antagonist that suppresses LH and sex steroid levels."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2288] "Antiviral agents that have a non-specific classification.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2289] "Therapeutic hormones that have a non-specific classification.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2290] "The hydrochloride salt form of Methaqualone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2291] "A vaccine comprise of a canarypox viral vector that carries the gene for human B7.1 (CD80 antigen) with potential use as an autologous therapeutic cancer vaccine.  Tumor cells harvested from a patient are infected with ALVAC-hB7 1, thereby producing an autologous cell line that exhibits increased expression of HLA class I and class II, CD54 (ICAM), and CD80. Increased expression of these proteins by this autologous cell line may activate an antitumor T-cell response when the modified cells are administered to the patient. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2292] "A recombinant form of the naturally occurring Interleukin-1 Receptor Antagonist that blocks the biological activity of Interleukin-1 by binding to the Interleukin-1 receptor.  Clinical Use: Rheumatoid Arthritis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2293] "A polymer implant which releases carmustine directly to surrounding tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2294] "A radioimmunoconjugate comprised of an IgG2 monoclonal antibody reactive with the extracellular matrix protein tenascin, which is overexpressed in gliomas, carcinomas of the breast and prostate, and other neoplasms, labelled with Iodine 131. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2295] "A radioimmunoconjugate comprised of an IgG2 monoclonal antibody reactive with the extracellular matrix protein tenascin, which is overexpressed in gliomas, carcinomas of the breast and prostate, and other neoplasms, labelled with Iodine 123. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2296] "Antitenascin antibody linked to an alpha-emitting radionuclide.  Being used in trial for treatment of glioma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2297] "A covalent conjugate of recombinant interferon alpha and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent.  The biological activity of this agent is derived from its interferon alpha protein moiety.  The PEG moiety lowers the clearance of interferon alpha, thereby extending the duration of its therapeutic effects.  Pegylation of interferon alpha may slightly increase the incidence of certain side effects, including injection site inflammation, fever, nausea, neutropenia, thrombocytopenia, and dermatitis; it may also reduce interferon alpha's ability to stimulate an immune response. (NCI04)"                                                                                                                                                                                                                                                                                                                                                       
 [2298] "Peptide vaccines derived from the tumor suppressor protein Von Hippel-Lindau (VHL).  The VHL gene produces two native protein products but can be absent in VHL disease. Since VHL disease is characterized by a genetic predisposition to the development of various forms cancers, the study of VHL gene and protein products is intensively pursued.  VHL peptides are designed and produced for biomedical research and vaccines that may stimulate a cytotoxic T-cell response in patients with VHL-associated cancers. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2299] "An adenovirus vector engineered to produce CD40 ligand.  For use as a possible gene therapy agent.  May induce apoptosis through the TNF pathway."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2300] "An analogue of the anthracycline antineoplastic antibiotic doxorubicin.  GPX-100 intercalates DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  GPX-100 was designed to be a non-cardiotoxic anthracycline antibiotic. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2301] "A radioimmunoconjugate comprised of biotin, a vitamin, conjugated to tetra-azacyclododecanetetra-acetic acid (DOTA), a chelating agent, and has been used in 3-step pre-targeting radioimmunotherapy protocols.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2302] "A monoclonal antibody directed against human Vascular Endothelial Growth Factor (VEGF), a protein that stimulates angiogenesis, and prevents VEGF from binding to its receptors, causing inhibition of angiogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2303] "A vaccine that expresses prostate-specific antigen for use in Immunotherapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2304] "A dye used as an imaging agent to stain lymph vessels. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2305] "A chimeric protein consisting of the Fv portion of a monoclonal antibody attached to a fragment of Pseudomonas exotoxin A without its cell-binding region.  LMB-1 immunotoxin targets B3, a Lewis Y-related carbohydrate epitope found on some solid tumors.  The antibody attaches to the tumor cell and the exotoxin stops protein synthesis by inactivating elongation factor 2 and disrupting protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2306] "A class of peptides, amino acid derivatives, and/or organic acids extracted from blood serum, urine, or synthetized chemically.  Antineoplastons inhibit the methylation of nucleic acids and the incorporation of L-glutamine into tumor-cell proteins.  These agents also intercalate into DNA, leading to cell cycle arrest in the G1 phase and inhibition of mitosis and terminal cell differentiation.  In addition, antineoplastons may inhibit RAS oncogene expression and activate the tumor suppressor gene p53, resulting in cell differentiation and apoptosis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2307] "A commercial vaccine; elicits a T-cell dependent antibody (B-cell) response to the STn antigen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2308] "A synthetic formulation in which the antineoplastic agent cisplatin is encapsulated in lipids.  Cisplatin liposomal consists of small aggregates of cisplatin covered by a single lipid bilayer. Encasement in liposomes improves cisplatin's tumor bioavailability and toxicity profile. Liposomal encapsulation does not affect the pharmacological properties of cisplatin directly. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2309] "An anticancer drug that reduces the blood supply to tumors; it is a tubulin-binding agent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2310] "A fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity.  Dimethylxanthenone acetic acid induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis.  This agent also stimulates the anti-tumor activity of tumor-associated macrophages. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2311] "A murine monoclonal antibody directed against CD30, a cell surface antigen. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2312] "A radioimmunoconjugate comprised of folic acid labeled with Indium 111 for use in Radioimmunotherapy targeting tumor-associated folate receptors.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2313] "An anticancer drug that may prevent cancer cells from dividing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2314] "An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2315] "A recombinant protein consisting of the hu14.18 monoclonal antibody fused to the cytokine interleukin-2 (IL-2).  The monoclonal antibody portion of the fusion binds to tumor cells expressing the GD2 antigen (melanoma, neuroblastoma and certain other tumors), thereby delivering IL-2, which activates a cellular immune response directed against GD2-expressing tumor cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2316] "A vaccine comprised of a recombinant vaccinia virus that expresses DF3/MUC1, a cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2317] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2318] "A vaccine comprised of autologous dendritic cells-pulsed with alpha-Fetoprotein peptide, a peptide epitope derived from human alpha-fetoprotein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2319] "A fusion protein consisting of the Fv portion of a monoclonal antibody attached to a fragment of the Pseudomonas exotoxin A.  LMB-2 immunotoxin targets CD25 (also known as IL-2R?) which is expressed on activated normal T and B cells and macrophages and on the cells of various hematologic malignancies.  The antibody attaches to the cell and the exotoxin stops protein synthesis by inactivating elongation factor 2. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2320] "A murine monoclonal antibody directed against fibroblast activation protein, a tumor stroma antigen, with potential antitumor stroma activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2321] "A radioimmunoconjugate comprised of a monoclonal antibody directed against fibroblast activation protein, a tumor stroma antigen, labelled with Iodine 131. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2322] "An antineoplastic antibiotic drug that belongs to the family of drugs called ansamycins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2323] "A cancer vaccine prepared from human melanoma cancer cells. It can be used alone or with other therapy in treating melanoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2324] "An antitumor drug that belongs to the family of drugs called topoisomerase inhibitors. It is a camptothecin analogue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2325] "A liquid containing barium sulfate that is used in x-rays to highlight parts of the digestive system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2326] "A vaccine comprised of the human pancarcinoma antigen (KSA) conjugated with Keyhole Limpet Hemocyanin (KLH). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2327] "A vaccine made by recombinant technology where human DNA is inserted into fowlpox virus. The resulting antigen elicits immune response against cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2328] "An anticancer drug formed by the combination of diphtheria toxin and a colony-stimulating factor (GM-CSF). The colony-stimulating factor is attracted to cancer cells, and the diphtheria toxin kills the cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2329] "A monoclonal antibody directed against the CD19 antigen, expressed on human B lymphocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2330] "A monoclonal antibody directed against the CD20 antigen, expressed on the cell surface of B-cell lymphomas. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2331] "An allogenic vaccine comprised of irradiated, genetically modified prostate cancer cells transfected with a human Granulocyte Macrophage-Colony-Stimulating Factor gene. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2332] "An anticancer drug that belongs to the family of drugs called mitotic inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2333] "A radioimmunoconjugate comprised of a monoclonal antibody directed against the CD45 antigen, a tyrosine phosphatase known as the leucocyte common antigen required for T-cell and B-cell activiation, labelled with Iodine 131. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2334] "Beta-galactosyl(1-3)-N-acetylgalactosamine, a blood group-related carbohydrate antigen: the antigen is shielded in healthy tissue but uncovered in a large percentage of carcinomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2335] "A vaccine comprised of the Thompson-Friedenreich [TF(c)] antigen, a cell surface antigen, conjugated with Keyhole Limpet Hemocyanin (KLH). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2336] "A mixed-backbone oligonucleotide inhibiting DNA methyltransferase and preventing or reversing abnormal methylation of tumor suppressor genes, resulting in tumor growth inhibition or tumor regression.  MG98 has been in clinical trials for bladder and head and neck cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2337] "A vaccine comprised of a recombinant vaccinia virus encoding the melanoma associated antigen tyrosinase. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2338] "A radioimmunoconjugate comprised of a MUC1 monoclonal antibody (m170) labeled with Yttrium 90. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2339] "A radioimmunoconjugate comprised of a MUC1 monoclonal antibody (m170) labelled with Indium 111. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2340] "A commercial system for preparing patient-derived stem cells for the treatment of breast cancer patients following chemotherapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2341] "Hyaluronic acid is a glycoprotein usually found in synovial fluid.  Elevated serum levels are associated with liver disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2342] "A genetically engineered canarypox vector that causes the infected cells to temporally display tumor-associated antigens (TAA) linked to a specific cancer. This may cause strong T-cell immune responses against tumor cells displaying the same TAA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2343] "A cancer vaccine comprised of peptides derived from the extracellular domain of the tumor-associated antigen Her-2/neu with potential antineoplastic activity. HER-2/neu peptide vaccine may induce antibodies with anti-tumor activity and may also elicit a specific CD8 T-cell response against specific tumor cell types. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2344] "A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2345] "A drug that may inhibit tumor cells from multiplying. It is being studied for its ability to treat cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2346] "A vaccine comprised of autologous dendritic cells pulsed with mutant p53 peptide. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2347] "A radioimmunoconjugate comprised of a monoclonal antibody directed against the Polymorphic Epithelial Mucin (PEM), overexpressed in epithelial tumor cells, labelled with Yttrium 90. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2348] "Cells isolated from lymph nodes from patients, and activated in vitro to generate tumor-specific effector T cells.  Lymph nodes in the lymphatics draining tumors often contain T cells that are immunologically sensitized but functionally deficient. Vaccine-sensitized draining lymph node cells are prepared by isolating these lymphocytes in vitro and stimulating them with cytokines to differentiate into mature effector cells.  Vaccine-draining lymph node cells may also be produced by pharmacological activation of lymph node-derived lymphocytes with drugs such as ionomycin or with bacterial toxin; these activated lymphocytes may be expanded in culture with cytokines such as interleukin-2 prior to infusion into the patient. (NCI04)"                                                                                                                                                                                                                                   
 [2349] "A murine IgG2 monoclonal antibody directed against the CD20 antigen, found on the surface of B-cells, for use in Radioimmunotherapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2350] "An immunoconjugate comprised of an anti-CD19 monoclonal antibody conjugated with Genistein selectively targeting B-lineage progenitor cells and inhibiting protein tyrosine kinase, causing apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2351] "A gene viral vector complex comprised of a replication-defective adenovirus and a herpes simplex virus thymidine kinase gene that activates ganciclovir, causing inhibition of DNA synthesis and apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2352] "A hybrid peptide of 19 amino acids derived from ovalbumin and BiP, an endoplasmic reticulum chaperone and a member of the Heat Shock 70 Protein Family, used to potentiate antigen presentation and consequently prime cytotoxic T lymphocyte responses. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2353] "A humanized monoclonal antibody directed against Lewis Y, an antigen expressed in epithelial cancers. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2354] "A recombinant fusion protein comprised of Prostatic Acid Phosphatase linked to Granulocyte Macrophage-Colony-Stimulating Factor (Sargramostim) for use in Vaccine Therapy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2355] "A gene that encodes interleukin-2, a growth factor for T-cells, that are transduced into autologous tumor cells for use in Gene Therapy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2356] "A radioactive form of palladium (a metallic element that resembles platinum). When used to treat prostate cancer, radioactive seeds (small pellets that contain radioactive palladium) are placed in the prostate. Cancer cells are killed by the energy given off as the radioactive material decays (breaks down)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2357] "A quinolinone derivative that inhibits farnesyl protein transferase, an enzyme that mediates the farnesylation of RAS, causing possible inhibition of the RAS pathway.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2358] "A radioimmunoconjugate comprised of humanized anti-Lewis Y antigen labelled with Indium 111.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2359] "A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2360] "A substance added to a vaccine to improve the immune response so that less vaccine is needed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2361] "A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2362] "A genetically modified Salmonella bacterium that is injected into the tumor.  It is being studied for its ability to shrink solid tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2363] "A radioimmunoconjugate comprised of a colloid formulation of human serum albumin labelled with Technetium 99m for diagnostic purposes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2364] "A synthesized version of a naturally occurring dipeptide consisting of L-glutamic acid and L-tryptophan.  IM-862 inhibits vascular endothelial growth factor (VEGF), thereby inhibiting angiogenesis, and increases the production of IL-12, thereby stimulating the immune system. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2365] "A therapeutic analogue of the endogenous CXC cytokine macrophage inflammatory protein-2 alpha. Macrophage inflammatory protein-2 alpha attracts and activates neutrophils and may play a role in cell proliferation.  In experimental models of acute hepatic injury, macrophage inflammatory protein-2 alpha has been shown to promote liver regeneration by stimulating the proliferation of hepatocytes. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2366] "A formulated therapeutic analog of the endogenous pro-inflammatory alpha (CXC) chemokine macrophage inflammatory protein-2 beta that stimulates neutrophil chemotaxis and induces neutrophil degranulation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2367] "A low level of T-cell receptor-rearrangement excision DNA circles (TREC) in the peripheral blood T cells of HIV-infected patients is an independent predictor of disease progression"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2368] "Oils obtained from food sources.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2369] "Essential fatty acids obtained from food sources that are necessary for normal biological functions, as well as growth and development.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2370] "The sodium form of allopurinol, which is a structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2371] "A desiccated form of natural thyroid from animal tissue comprised mostly of triiodothyronine (T3) and thyroxine (T4).  Clinical Use: Hypothyroidism and Wilsons Syndrome.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2372] "An immunostimulant adjuvant used to increase the effect of chemotherapeutic agents and vaccines, including Theratope and Melacine.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2373] "A monoclonal antibody that recognizes the tumor-associated mucin Tag-72"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2374] "Hydrocortisone used as a placebo in comparative studies.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2375] "A synthetic agent derived from human papillomavirus (HPV) E7 nuclear protein which is used to produce vaccines against HPV infection and HPV-related neoplasms.  HPV E7 oncogenic protein binds the retinoblastoma tumor suppressor protein, pRB, as well as a number of other cellular proteins, and serves as a transcriptional activator.  This protein is important in the induction and maintenance of cellular transformation and is co-expressed in the majority of HPV-containing carcinomas.  PADRE(R) is a proprietary family of molecules that enhances the immune systems response against an administered immunogen such as the HPV E7 nuclear protein. (NCI04)"                                                                                                                                                                                                                                                                                                                       
 [2376] "A butyric acid analog that stimulates hemoglobin F synthesis and induces the expression of Epstein-Barr Virus (EBV) Thymidine Kinase, inducing EBV Thymidine Kinase transcription. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2377] "A substance that is being studied as an anticancer drug.  It is an analogue of a substance that occurs naturally in the body (cyclic adenosine monophosphate)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2378] "A murine monoclonal antibody directed against the CD20 phosphoprotein, expressed on the cell surface of normal B-lymphocytes and B-cell lymphomas.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2379] "A radioimmunoconjugate comprised of a monoclonal antibody directed against CD22, a transmembrane glycoprotein expressed by B-cells, labelled with Technetium 99m.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2380] "A liquid composed of two immiscible substances, typically some form of fat and water. In parenteral nutrition, a fat emulsion may contain phospholipids, triglycerides and essential fatty acids (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2381] "A vaccine comprised of autologous dendritic cells pulsed with a recombinant prostate specific membrane antigen. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2382] "Substances comprised of fragmented heparin molecules derived from unfractionated heparin that bind to antithrombin III with a molecular weight ranging from 1000 to 10,000 daltons, which causes changes in property from unfractionated heparin, including decreased protein binding, enhanced bioavailability, decreased platelet interaction, and decreased binding to thrombin.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2383] "A radioimmunoconjugate comprised of murine anti-CD22 monoclonal antibody, Ibritumomab, covalently bound to a linker-chelator, Tiuxetan, labelled with Indium 111 used for imaging in Radioimmunotherapy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2384] "An agent containing the saponin QS21 and Monophosphoryl Lipid A in an oil-in-water emulsion for use as an adjuvant in Vaccine Therapy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2385] "A thyroid hormone. Also called triiodothyronine or T-3."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2386] "A radioimmunoconjugate comprised of humanized LL2, an anti-CD22 pan-B-cell monoclonal antibody, labeled with Yttrium 90 having a pro-apoptotic effect on tumor cells expressing CD22 antigen. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2387] "A drug taken to help reduce the amount of sugar in the blood. Rosiglitazone helps make insulin more effective and improves regulation of blood sugar. It belongs to the family of drugs called thiazolidinediones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2388] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2389] "A fibrin sealant used to reduce surgical bleeding and has been used as a physiological tissue adherent drug carrier.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2390] "A furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.  Psoralen is used in Photochemotherapy or PUVA (Psoralen with high-intensity long-wavelength UVA irradiation). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2391] "A recombinant, chimeric cytokine that exerts a variety of effects on the hematopoietic and immune systems.  Progenipoietin consists of portions of granulocyte colony-stimulating factor (G-CSF) and the ligand for human fetal liver tyrosine kinase-3 (FLT3).  When administered in vivo, both molecules have been shown to augment the number of circulating dendritic cell (DC) precursors. This agent also appears to be anti-apoptotic for some cell types. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2392] "A gadolinium-diethylenetriamine pentaacetic acid complex that acts as a paramagnetic contrast agent for Magnetic Resonance Imaging (MRI). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2393] "An herbal medication, also known as St. Johns Wort, that induces drug metabolizing enzymes, particularly CYP3A4, and p-glycoprotein, a transporter, and is used in Alternative Medicine for treating mild depression, premenstrual syndrome, and seasonal affective disorder. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2394] "A vaccine made of antibodies that see other antibodies as the antigen and bind to it.  Anti-idiotype vaccines can stimulate the body to produce antibodies against tumor cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2395] "A colorless oily liquid used as a flavoring agent and to make dyes, perfumes, and pharmaceuticals. Benzaldehyde is chemically related to benzene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2396] "A murine IgG2a monoclonal antibody that targets CD33, a 67-kD cell surface glycoprotein expressed on myeloid leukemia cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2397] "The carboxyl terminal autophosphorylation portion of the intracellular domain of HER2 for use in Vaccine Therapy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2398] "Dendritic cells obtained from the donor.  Antigen-pulsed autologous dendritic cells are being developed for the use in immunotherapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2399] "A culture filtrate of cells of Candida Albicans propagated in a chemically defined medium and used as a recall antigen to evaluate cellular immunity in infection, cancer, and other disease states. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2400] "A vaccine comprised of a peptide from MAGE-12, a protein fraction expressed by melanoma, colorectal, breast, and non-small cell lung cancer, and sarcoma. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2401] "A radioimmunoconjugate comprised of a monoclonal antibody directed against the tumor associated glycoprotein 72 (TAG-72), an antigen expressed on human breast, colorectal, and other carcinomas, labelled with Yttrium 90. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2402] "A radioimmunoconjugate comprised of a monoclonal antibody directed against the tumor associated glycoprotein 72 (TAG-72), an antigen expressed on human breast, colorectal, and other carcinomas, labelled with Lutetium 177. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2403] "A recombinant chimeric protein composed of Interleukin-13 (IL-13) linked to a mutated form of Pseudomonas Endotoxin A and targets tumor cells that express IL-13 receptors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2404] "A radioimmunoconjugate comprised of a humanized anti-TAC monoclonal antibody linked to Yttrium 90. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2405] "A radioimmunoconjugate comprised of a somatostatin peptide analog, Tyr 3-octreotide, conjugated to tetra-azacyclododecanetetra-acetic acid (DOTA) linked to Yttrium 90 and targets somatostatin receptor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2406] "A formulation containing carmustine dissolved in ethanol for intra-tumoral administration that allows carmustine to enter both aqueous and lipid compartments of the target tissue. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2407] "A centrally acting reversible, non-competitive inhibitor of acetylcholinesterase, an enzyme that hydrolysis acetylcholine, causing increased acetylcholine activity and may be useful in memory disorders. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2408] "A radioimmunoconjugate comprised of a monoclonal antibody directed against the external domain of the prostate specific membrane antigen (PSMA) labelled with Iodine 131. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2409] "A disulfide agent that stimulates T and B-cell functions and exhibits anti-tumor and immunostimulant activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2410] "A vaccine consisting of a monoclonal antibody (MoAB) directed against an idiotype that mimics a human milk fat globule (HMFG) membrane epitope.  Vaccination with monoclonal antibody 11D10 anti-idiotype vaccine induces anti-anti-idiotype antibodies (Ab3) that may react with breast cancer cell lines expressing the HMFG membrane epitope. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2411] "A radioimmunoconjugate comprised of a IgG1 monoclonal antibody (BrE-3) that target epitopes of epithelial glycoprotein mucin (MUC-1) linked to Yttrium 90.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2412] "A radioimmunoconjugate comprised of an IgG1 monoclonal antibody that targets epitopes of epithelial glycoprotein mucin (MUC-1) linked to Indium 111. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2413] "An immunotoxin comprised of a single chain anti-mesothelin monoclonal antibody, SS1(dsFv), linked to Pseudomonas Exotoxin PE-38 that binds to cells expressing mesothelin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2414] "A panadenocarcinoma murine monoclonal antibody with potential antineoplastic activity.  Monoclonal antibody m170 may be conjugated with a radioactive element and used in radioimmunotherapy (RIT), a procedure that uses a tumor-specific monoclonal antibody to target radiation to cancer cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2415] "An immunotoxin comprised of a monoclonal antibody directed against CD22, an antigen expressed on B lymphocytes, linked to a chemically deglycosylated ricin-A chain toxin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2416] "A vaccine comprised of an epitope from the ESO-1 antigen used in Immunotherapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2417] "A short acting, inhaled P2Y2 receptor agonist used to stimulate lung mucociliary clearance. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2418] "A radioimmunoconjugate comprised of a monoclonal antibody directed against a carbohydrate antigen Le(Y), present on many human solid tumors, linked to Yttrium 90. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2419] "A radioimmunoconjugate comprised of a monoclonal antibody directed against a carbohydrate antigen Le(Y), present on many human solid tumors, linked to Indium 111. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2420] "A somatostatin peptide analog Tyr3-octreotide conjugated to tetra-azacyclododecanetetra-acetic acid (DOTA) that targets somatostatin receptors and is used in Radiotherapy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2421] "A phosphorothioate oligonucleotide targeting the translation site of epidermal growth factor receptor (EGFR) mRNA, causing suppression of EGFR protein expression and tumor cell growth.  EGFR Antisense DNA has been in clinical trials for head and neck cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2422] "An agent that inhibits tubulin by inhibiting DNA polymerase and weakly binding to the colchicine site of tubulin, causing inhibition of mitosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2423] "A vaccine comprised of a recombinant vaccinia virus encoding the Carcinoembryonic Antigen (CEA) and TRICOM, the genes for three co-stimulatory molecules B7.1, ICAM-1, and LFA-3 that enhance antigen presentation and activate cytotoxic T-cells, that targets CEA-expressing tumors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2424] "A cancer vaccine comprised of a recombinant fowlpox virus vector encoding the carcinoembryonic antigen (CEA) and TRICOM. TRICOM is comprised of three co-stimulatory molecule transgenes (B7-1, ICAM-1 and LFA-3). This agent may enhance CEA presentation to antigen presenting cells (APC) and activate cytotoxic T-cells against CEA-expressing tumors. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2425] "A IgM murine monoclonal antibody that targets CD147, an antigen expressed by T-, B-, and Natural Killer (NK) cells, causing immunosuppression. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2426] "A peptide fragment of Carcinoembryonic Antigen (CEA) containing 7 amino acids used in Immunotherapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2427] "An oncolytic virus genetically engineered from the herpes simplex type 1 virus.  NV1020 has been in clinical trials for hepatic metastasis from colon cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2428] "A bispecific antibody containing a 4G7 hybridoma secreting IgG1 antibody specific for B-lymphocytes and a monoclonal antibody targeting Fc gamma RI-expressing cells.  Bispecific antibody 4G7xH22 has been used in clinical trials for non-Hodgkin's lymphoma and leukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2429] "A humanized monoclonal antibody that targets the fusion protein (F protein) of respiratory syncytial virus (RSV), causing neutralization and fusion-inhibition activity against both type A and B RSV isolates.  Clinical Use: Respiratory Syncytial Virus-Prophylaxis.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2430] "A Chinese herb that has been used as a treatment for a variety of medical problems.  It is being studied as an anticancer drug."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2431] "A semi-synthetic saponin that acts as an adjuvant in Vaccine Therapy and immune enhancer by stimulating Th1 immunity, causing synthesis of antigen-specific cytotoxic T-cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2432] "A vaccine comprised of MUC2, a cell surface antigen, and Globo H (Globo H Hexasaccharide 1), a tumor-associated complex carbohydrate antigen, conjugated with Keyhole Limpet Hemocyanin, an immunomodulator, that induces IgM and IgG antibodies and mediate complement dependent and/or antibody dependent cell mediated cytotoxicity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2433] "An antiviral agent that is being studied as a treatment for AIDS-related cytomegalovirus.  It is changed in the body to ganciclovir."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2434] "An immunoconjugate comprised of a monoclonal antibody targeting KSA, an epithelial cell adhesion molecule (Ep-CAM), fused to recombinant Interleukin-2, a cytokine that activates cytotoxic T-lymphocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2435] "A liposome-encapsulated formulation of paclitaxel. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2436] "A lipophilic, anthracycline antineoplastic antibiotic. Annamycin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also circumvents multidrug-resistance (MDR) transporters, including p-glycoprotein. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2437] "A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called glycinamide ribonucleotide formyl transferase inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2438] "A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels.  In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2439] "A substance that is being studied in the prevention and treatment of scar tissue caused by radiation therapy.  It belongs to the family of drugs called anti-inflammatory agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2440] "2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a.  A drug that is used in photodynamic therapy that is absorbed by tumor cells; when exposed to light, it becomes active and kills the cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2441] "A vaccine comprised of an engineered, chimeric HER-2 B-cell epitope [MVF-HER-2(638-647)] coated with a poloxamer (CRL-1005), a synthetic polymer, to form microparticles. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2442] "A recombinant engineered chimeric gene derived from the murine gene encoding the variable region of monoclonal antibody MOv18 against folate-binding protein, which is often overexpressed in human ovarian cancer cells, and the gene encoding the Fc receptor for the gamma subunit of human IgG and IgE. Peripheral blood lymphocytes expressing the MOv-gamma gene may be used in the immunotherapeutic treatment of ovarian cancer. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2443] "A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called anti-infectives."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2444] "A recombinant peptide consisting of the amino acid residues 540 to 548 of the human telomerase reverse transcriptase (hTERT). Telomerase expression has been directly linked to tumor development; its catalytic subunit is expressed in the majority of human cancer cells, but infrequently in normal cells.  Vaccination with telomerase:540-548 peptide may stimulate cytotoxic T cells to recognize and kill telomerase-expressing cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2445] "A small molecule compound activated by Glutathione S-Transferase P1-1, an enzyme overexpressed in many human cancers, inducing apoptosis by activating the stress-response apoptosis signaling pathway. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2446] "A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called signal transduction inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2447] "A sterile mixture of two inactivated influenza virus type A and one type B."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2448] "Anthracycline antineoplastic antibiotic doxorubicin bound to microscopic beads of activated carbon and iron (magnetic targeted carriers).  With placement of a magnet on the body surface overlying a tumor site, this carrier complex delivers doxorubicin directly to the tumor, thereby prolonging the duration of the therapeutic effects while decreasing its systemic toxicity.  Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. (NCI04)"                                                                                                                                                                                                                                                                                                                  
 [2449] "A Vitamin D analog whose active metabolites bind to the Vitamin D receptor, located in various tissues of the body affecting bone, parathyroid glands, white blood cells and the intestine, causing decreased parathyroid hormone secretion and to a lesser degree calcium and phosphorus metabolism. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2450] "A differentiation antigen expressed in many melanoma cell lines.  Peptides from this antigen are used in Vaccine Therapy to elicit an immune response.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2451] "A drug used in photodynamic therapy; it is absorbed by tumor cells and, when exposed to light, becomes active and kills the cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2452] "A vaccine comprised of a anti-idiotype monoclonal antibody that mimics gp72, a tumor-associated antigen expressed on most colorectal tumor cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2453] "A combination of DHA (a natural fatty acid) and paclitaxel (an anticancer drug) that is being studied as a treatment for cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2454] "A vaccine comprised of a plasmid DNA encoding Synchrotope, a proprietary antigen discovery system, TA2M antigen. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2455] "A synthetic photosensitizer agent containing a large macrocyclic ring with chelated silicon, Silicon Phthalocyanine 4 localizes primarily in mitochondrial cytosolic membranes forming a reactive oxygen species that causes apoptosis, although studies suggest involvement in multiple pathways. Photodynamic therapy is a promising treatment modality for cutaneous neoplasms. Photochemical decontamination of red blood cell concentrates with silicon phthalocyanine 4 is being studied to increase the safety of blood products. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2456] "A humanized monoclonal antibody directed against the external domain of the prostate specific membrane antigen (PSMA) for use in Immunotherapy and Immunostaining. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2457] "A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called alkylating agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2458] "A monoclonal antibody directed against Cytotoxic T-Lymphocyte-Associated-4 (CTLA4), expressed on activated T-cells and has an affinity for the B7 co-stimulatory molecules, causing enhanced T-cell activation and blockade of the B7-1 and B7-2 T-cell costimulator pathways. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2459] "A substance that is being studied as a treatment for oral mucositis (painful mouth sores) caused by cancer therapy.  It belongs to the family of drugs called synthetic protegrin analogs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2460] "A quinazolinone alkaloid anticoccidial with potential antineoplastic activity.  Halofuginone hydrobromide inhibits type I collagen synthesis and matrix metalloproteinase 2 gene expression, which results in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2461] "A vaccine comprised of an epitope from NY-ESO-1, a cancer-testis antigen overexpressed on various cancer cells, to induce a NY-ESO-1 specific immune response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2462] "A bispecific antibody containing a monoclonal antibody targeting CD3-expressing effector cells and a monoclonal antibody targeting HER2/neu-expressing tumor cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2463] "A humanized monoclonal antibody targeted against the Parathyroid Hormone-Related Protein, a protein commonly expressed by breast and prostate cancers involved with calcium release, renal calcium excretion, and renal phosphate reabsorption. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2464] "A solution of formaldehyde-deactivated toxin isolated from the bacterium Clostridium tetani. Tetanus toxoid stimulates the production of antitoxin antibodies. This agent may be used as an adjuvant in cancer vaccines. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2465] "A chinese herb containing flavonoids, baicalin, and baicalein that exhibits antioxidant, free radical scavenging, and antiinflammatory activity, and inhibition of tumor growth. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2466] "A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called topoisomerase II beta inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2467] "Herbs used in Chinese Herbal Therapy for toxicity attenuation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2468] "A compound applied topically comprised of fibrinogen and thrombin that form fibrin, resulting in a semi rigid fibrin clot and hemostasis.  Fibrin sealant exhibits reduction of total fluid drainage and seromas after breast surgery. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2469] "A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called topoisomerase I inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2470] "A vaccine comprised of a recombinant fowlpox virus that encodes the gene for B7.1 co-stimulatory molecule to induce T-cell activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2471] "A cancer vaccine comprised of a recombinant fowlpox virus vector encoding TRICOM. TRICOM is comprised of three co-stimulatory molecule transgenes (B7-1, ICAM-1 and LFA-3) that may enhance antigen presentation and activate cytotoxic T-cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2472] "A substance that is similar to thalidomide, and that prevents the growth of new blood vessels to solid tumors.  It belongs to the family of drugs called angiogenesis inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2473] "A monoclonal antibody directly targeting Interleukin-2R-beta subunit, expressed on T-cell Large Granular Lymphocytic (T-LGL) Leukemia cell surface, preventing Interleukin-2-mediated proliferation and activation into lymphokine-activated killer cells of T-LGL. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2474] "An agent that inhibits both mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), substrates of Raf and phosphorylates extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), preventing phosphorylation and activation of the Mitogen-Activated Protein Kinase (MAPK) pathways, involved with signal transduction pathways and tumor proliferation.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2475] "An orally-agent agent with potential antineoplastic activity.  S-3304 inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2476] "A polyketide extract from the myxobacteria Sorangium cellulosum that shares the binding site on tubulin with Paclitaxel, causing tubulin polymerization and microtubule stabilization.  Unlike Paclitaxel, Epothilone D shows cytotoxic activity in p-glycoprotein Multidrug Resistant (MDR) cell lines. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2477] "A thienopyridine antiplatelet agent that inhibits binding of adenosine diphosphate (ADP) to its platelet receptor, causing subsequent ADP-mediated activation of the glycoprotein complex gpIIb/IIIa leading to platelet aggregation inhibition.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2478] "A vaccine comprised of a recombinant vaccinia virus encoding the gene for Granulocyte-Macrophage Colony-Stimulating Factor (Sargramostim, GM-CSF). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2479] "A vaccine comprised of a recombinant fowlpox virus encoding the gene for Prostate Specific Antigen (PSA). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2480] "An oncolytic virus genetically engineered from the herpes simplex virus.  G207 has been used in clinical trials for malignant glioma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2481] "Microparticles comprised of metallic iron and activated carbon used as a delivery vehicle for pharmaceutical agents.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2482] "A type of polysaccharide (string of sugar molecules) obtained from several types of mushrooms. It is being studied as a treatment for cancer and as an immune system stimulant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2483] "A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called sulfonamides."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2484] "An adjunct antigen used in the development of vaccine therapy against tumor cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2485] "A melanoma tumor-associated antigen used in the development of vaccine therapy against tumor cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2486] "A protein comprised of segments of the extracellular domains of human vascular endothelial growth factor receptors 1 (VEGFR1) and 2 (VEGFR2) fused to the constant region (Fc) of human IgG1.  VEGF trap binds to vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor, thereby preventing VEGF from binding to its cell receptors.  Disruption of this cell receptor binding results in the inhibition of angiogenesis and metastasis, and tumor regression. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2487] "A murine monoclonal antibody that was in clinical trial for Advanced Colorectal or Gastric Carcinoma.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2488] "A human IgM monoclonal antibody directed against human Cytomegalovirus. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2489] "A vaccine comprised of a recombinant vaccinia virus and TRICOM, the genes for three co-stimulatory molecules B7.l, ICAM-1, and LFA-3 that enhance antigen presentation and activate cytotoxic T-cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2490] "A vaccine comprised of a recombinant fowlpox virus encoding the gene for Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF, Sargramostim) used to enhance the immune response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2491] "A humanized anti-CD3 monoclonal antibody targeting activated T-cells, inducing apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2492] "A nanoparticle colloidal composition of a protein-stabilized formulation of Paclitaxel. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2493] "An oligomeric proanthocyanidin extracted from grape seeds that exhibits dose-dependent free-radical scavenging and antioxidant properties, resulting in broad spectrum therapeutic and chemoprotective uses. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2494] "A formulation containing seven chinese herbs with Baicalein, a flavone, the principal component exhibiting hepatoprotective, antiproliferative, and immunostimulatory properties. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2495] "A phytochemical containing a phenolic substance, 6-gingerol, exhibiting antioxidant and antiinflammatory properties and used in cooking and as a herbal remedy for indigestion and motion sickness. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2496] "A family of drugs that block DNA synthesis and may prevent tumor growth. They are being studied as a treatment for cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2497] "A quinazoline derivative with antineoplastic properties.  Competing with adenosine triphophate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2498] "A combination of substances extracted from the shrub Camellia sinesis, a plant native to Asia.  Green tea extract contains antioxidant compounds, including flavonoids, vitamins and polyphenols such as epigallocatechin-3-gallate (EGCG), which may have antineoplastic properties.  Consumption of green tea extract may have a chemopreventive effect on various cancers including prostate, stomach, and esophageal cancers.  Herbalists use green tea extract for stomach problems, vomiting, diarrhea, and to reduce tooth decay, blood pressure, and blood cholesterol levels. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                     
 [2499] "A colony-stimulating factor that is made in the laboratory. It increases the production of red blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2500] "A radioconjugate comprised of lipiodol, iodinated ethyl esters of fatty acids in poppy seed oil, labelled with Iodine 131 for use in Radiotherapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2501] "A humanized CH2 domain deleted monoclonal antibody CC49 that reacts with Tumor-Associated Glycoprotein (TAG)-72 with superior tumor-targeting than the parent, Monoclonal Antibody CC49, linked to Iodine 131. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2502] "A humanized CH2 domain deleted monoclonal antibody CC49 that reacts with Tumor-Associated Glycoprotein (TAG)-72, a human pancarcinoma antigen, with superior tumor-targeting than the parent, Monoclonal Antibody CC49, for use in Radiotherapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2503] "Prodrugs that are released by a cells drug resistance enzyme to the active form, causing cell death with decreased toxicity.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2504] "A partially purified preparation isolated from the thymus and containing several peptides. Human Thymosin-Fraction 5 (TF-5) possesses immunopotentiating properties and can correct many of the immunological deficiencies resulting from the lack of thymosin function in animal models and in humans. This agent enhances the spontaneous natural killer activity of normal human large granular lymphocytes; exhibits additive effects with recombinant IFN-alpha in enhancing natural killer activity in vitro and; enhances IL2 production, IL2 receptor expression, and IFN-gamma production in mitogen-stimulated large granular lymphocytes. TF-5 may also modulate the secretion of some hypothalamic peptides and pituitary hormones, including prolactin and growth hormone. (NCI04)"                                                                                                                                                                                                    
 [2505] "A preparation of plasma proteins derived from the pooled plasma of adult donors that is largely comprised of IgG antibodies.  Therapeutic immune globulin provides passive immunization by increasing the recipient's serum levels of circulating antibodies.  IgG antibodies have multiple functions, including binding to and neutralizing bacterial toxins; opsonization of pathogens; activation of complement; and suppression of pathogenic cytokines and phagocytes by binding to CD5, interleukin-1a (IL-1a), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and T-cell receptors.  Therapeutic immune globulin may diminish pathogenic mechanisms in some autoimmune diseases by binding to and inhibiting the activity of autoantibodies. (NCI04)"                                                                                                                                                                                                                        
 [2506] "A liposome-encapsulated formulation of Vincristine Sulfate. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2507] "A substance that comes from the mistletoe plant and that is being studied as a treatment for cancer.  A lectin is a complex molecule that has both protein and sugars. Lectins are able to bind to the outside of a cell and cause biochemical changes in it. Lectins are made by both animals and plants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2508] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2509] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2510] "An antineoplastic antibiotic that intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  Anthrapyrazoles may also block cell cycle division.  In the presence of electron donors, some anthrapyrazole antibiotics cause single-strand breaks in DNA via photosensitization by visible light.  These agents are less cardiotoxic than doxorubicin. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2511] "A steroidal alkylating agent with potential antineoplastic activity.  Alkylating agents exert cytotoxic and, in some cases, chemotherapeutic effects by transferring alkyl groups to DNA, thereby damaging DNA and interfering with DNA replication and cell division. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2512] "A mixture composed of curcuminoid phenols extracted from the plant Curcuma longa (turmeric root) with potent antioxidant and anti-inflammatory properties.  Curcumin C3 complex is a unique combination of three phenols: curcumin, demethoxycurcumin and bisdemethoxycurcumin.  This agent may both prevent the formation of free radicals and neutralize free radicals.  Curcuminoids may have chemopreventive and antiproliferative properties. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2513] "CMAP Definition: Ken Foon"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2514] "Autologous human dendritic cells pulsed with RNA encoding the carcinoembryonic antigen (CEA) are being studied for possible use in the treatment of cancer expressing CEA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2515] "An inhibitor of microtubule polymerization derived from the South African willow bush which causes mitotic arrest and selectively targets and reduces or destroys existing blood vessels, causing decreased tumor blood supply.  Combretastatin A4 has been in clinical trials for solid tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2516] "CMAP Definition: mAb (human)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2517] "A synthetic cyanoquinoline derivative with potential antineoplastic activity. As an irreversible inhibitor of epidermal growth factor receptor (EGFR) and the Erb2 receptor, EKB-569 may inhibit the growth of cells that overexpress either EGFR or Erb2. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2518] "CMAP Definition: mAb (mouse)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2519] "A derivative of rhodacyanine with potential antineoplastic activity.  FJ5002 inhibits telomerase by interfering with holoenzyme assembly and telomere interaction, thus leading to replication-dependent shortening of telomeres with a concurrent increase in aneuploid metaphases and apoptotic cells.  Telomerase is active in most tumors cells, but is quiescent in adjacent normal cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2522] "A cancer vaccine consisting of Her2/neu peptides incorporated into microspheres of poly (lactide-co-glycolide) (PLGA), a biodegradable polymer.  Poly microsphere encapsulated HER2/neu oral vaccine has been investigated for use in immunotherapy for tumors positive for HER-2/neu, a tumor associated antigen that is overexpressed in various cancers, including breast and ovarian cancer. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2523] "A humanized monoclonal antibody directed against vascular endothelial growth factor (VEGF), a pro-angiogenic cytokine.  HuMV833 has been shown to decrease the permeability of blood vessels that supply tumors, an effect which may lead to slowed tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2524] "A rat monoclonal antibody that inhibits Epidermal Growth Factor Receptor (EGFR), targeting tumor cells expressing the wild-type EGFR and EGFRvIII. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2525] "A substance that is being studied in the treatment of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2526] "A synthetic triarylimidazole with potential antineoplastic activity.  As a Raf kinase inhibitor, L-779450 competes with ATP for binding to the Raf-1 and A-Raf catalytic sites, thus inhibiting their enzymatic activities and blocking various signal transduction pathways that depend on Raf-1 kinase (particularly the Ras-Raf-MEK-ERK cascade which is often up-regulated in neoplasms). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2527] "CMAP Definition: Residues 170-178 recognized by TILs in context of HLA-Cw0702"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2528] "A substance that is being studied in the treatment of cancers of the blood . It belongs to the family of drugs called histone deacetylase inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2529] "CMAP Definition: Antigen initially described in colorectal cancer. Mab CO17-1A also used as immunogen in preclinical development of anti-idiotypic antibody BR3E4 (Thomas Jefferson Univ. and Wistar Institute)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2530] "CMAP Definition: Tumor-reactive antibody against carbohydrate epitope on cell surface proteins (Note: distinct from pan-cytokeratin antibody A45-B/B3)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2531] "CMAP Definition: Kinase Inhibitor"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2532] "CMAP Definition: Multiple antigens conjugated to KLH- QS21 or Gp-100; Memorial Sloan Kettering Cancer Center"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2534] "Point-mutation products of Ras proto-oncogene are found to associated with a broad spectrum of human carcinomas.  Mutations location are notably at codons 12 , 13, and 61. Codon 12 mutations form more than 90% of all Ras mutations in human cancers.  Degraded Ras peptides have been shown to stimulate immunogenic response.  Various forms of mutated Ras peptides-adjuvant are used as vaccine along with cytokines that could potentially enhance the body's immunological response in many neoplastic conditions. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2535] "CMAP Definition: Preclinical"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2536] "CMAP Definition: Recombinant vaccinia virus expressing DF3/MUC1; phase I study in metastatic adenocarinoma"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2537] "CMAP Definition: mAb"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2538] "A modified version of Vitaxin, a humanized monoclonal IgG1 antibody to alpha(v)beta(3)integrin.  Exhibiting improved affinity to alpha(v)beta(3)integrin compared to first-generation Vitaxin, Vitaxin-2 blocks the binding of ligands, such as vitronectin, to alpha(v)beta(3) integrin, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2539] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2540] "A water-soluble phosphate prodrug of N-acetylcolchinol with potential antineoplastic activity.  ZD-6126 binds to and destabilizes the tubulin cytoskeleton of endothelial cells, thereby inhibiting angiogenesis which may result in tumor necrosis.(NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2541] "An orally bioavailable 4-anilinoquinazoline.  ZD-6474 selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability.  This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis.  (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2542] "CMAP Definition: n-(5-tert-butyl-3-isoxazoly)-N'-(4-(4-pyridinyl)oxyphenyl) urea Preclinical data only"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2543] "CMAP Definition: Blocks VEGFR-VEGF binding"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2544] "A peptide vaccine derived from the von Hippel-Lindau (VHL) tumor suppressor protein, a general transcription factor. VHL16 peptide, also known as S111I, is a point mutation variant of the VHL tumor suppressor protein; the mutation is in amino acid position 111.  Vaccination with this agent may stimulate a cytotoxic T-cell response in patients with VHL-associated cancers that express this variant of the VHL tumor suppressor protein. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2545] "A peptide vaccine derived from the von Hippel-Lindau (VHL) tumor suppressor protein, a general transcription factor.  VHL14 peptide is a point mutation variant of the VHL protein; the mutation is in amino acid position 166.  It might be used to elicit or boost cellular immunity to cancers that expressing the von Hippel-Lindau mutation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2546] "A cancer vaccine consisting of ALVAC, a highly attenuated poxvirus strain derived from the canarypox virus.  ALVAC-B7-CEA expresses carcinoembryonic antigen (CEA), a protein that is overexpressed by many tumor cells, and B7.1 (also known as CD80), the natural ligand for the T-cell antigen CD28, to augment the host immune response.  This agent has been shown to stimulate a host immune response against tumor cells that express CEA. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2547] "A replication-defective recombinant canarypox virus (ALVAC) that contains the entire human carcinoembryonic antigen (CEA) gene.  Vaccination with ALVAC-CEA (VCP248) may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against CEA-positive tumor cells, thereby decreasing tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2548] "The sulfate salt of atropine, a naturally-occurring alkaloid isolated from the plant Atropa belladonna.  Atropine functions as a sympathetic, competitive antagonist of muscarinic cholinergic receptors, thereby abolishing the effects of parasympathetic stimulation.  This agent may induce tachycardia, inhibit secretions, and relax smooth muscles. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2549] "An allogenic whole tumor cell vaccine with potential antineoplastic activity.  B7 transfected melanoma cell vaccine consists of melanoma cells that have been induced to express the human leukocyte antigen (HLA) B7.  Vaccination with these altered cells stimulates an anti-tumor immune response via CD8+ cytotoxic T lymphocytes (CTL). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2550] "A synthetic vaccine combining the peptide antigens of two proteins , ras oncoprotein and tumor suppressor p53. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2551] "A conjugate of a monoclonal antibody directed against the pancarcinoma antigen TAG-72 and a radioisotope. TAG-72 is a protein/sugar complex found on the surface of many cancer cells, including breast, colon, and pancreatic cancer cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2552] "A recombinant, chimeric protein derived from a melanoma antigenic epitope (MAGE-3) recognized by specific cytotoxic T lymphocytes.  MAGE-3 is a human peptide epitope present in the cytosol of cancer cells but usually not expressed in normal tissues.  It can be obtained and purified in vitro by expressing it as a fusion protein with a soluble, smaller peptide such as histidine.  D1/3-Mage-3 fusion protein may be used in vaccines to boost the body's natural defenses against cancer.  It is recognized by tumor-infiltrating lymphocytes, the adoptive transfer of which may be associated with tumor regression in melanoma. (NCI04)"                                                                                                                                                                                                                                                                                                                                              
 [2553] "An antisense oligonucleotide targeting the chimeric EWS/FLI 1 Type 1 gene, inhibiting proliferation of Ewing Family Tumor (EFT) cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2554] "An antisense oligonucleotide targeting the chimeric EWS/FLI 1 Type 2 gene, inhibiting proliferatin of Ewing Family Tumor (EFT) cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2555] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2556] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2557] "A 9-residued peptide vaccine consisting of amino acids 157 through 165 of the cancer/testis (CT) antigen ESO-1. Modified at position 165 (cysteine to valine) to improve immunogenicity, ESO-1:157-165(165v) peptide administered as a vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for ESO-1, resulting in decreased tumor growth. ESO-1 is expressed in a variety of cancers, including melanoma, breast, bladder, prostate, and hepatocellular cancers.  (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2558] "A synthetic derivative of dideoxyadenosine with anti-HIV activity. As an acid-stable dideoxypurine analogue, lodenosine inhibits reverse transcriptase inhibitor and may be active against HIV strains resistant to other nucleoside analogues. Hepatotoxicity and nephrotoxicity have limited its clinical usefulness. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2559] "Expression vectors containing the complementary DNA (cDNA) of the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) coated onto gold particles.  A protein cytokine secreted by T-cells and macrophages following cell activation by antigens or mitogens, GM-CSF is indispensable for the growth and development of granulocyte and macrophage progenitor cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2560] "A vaccine consisting of a replication-defective recombinant adenovirus that encodes the melanoma antigen glycoprotein 100 (gp100) with potential antineoplastic activity.  Vaccination with gp100 adenovirus vaccine stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the gp100 antigen, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2561] "A synthetic agent derived from the tumor-associated differentiation antigen gp100 DNA.  Gp100 DNA is coated onto microscopic gold beads and used to immunize animals and generate polyclonal antibodies that specifically recognize gp100 antigen.  Gp100 human antigen is a non-mutated self-antigen expressed by melanocytes, pigmented retinal cells and most melanoma lesions, but is not expressed in other normal tissues or non-melanoma tumors.  Immunization with human gp100 DNA may induce protective immunity against melanoma and may provide an effective approach for vaccine therapy with tumor-associated antigens against human melanoma. (NCI04)"                                                                                                                                                                                                                                                                                                                                
 [2562] "A vaccine consisting of plasmid DNA encoding the glycoprotein 100 (gp100) melanoma antigen with potential antineoplastic activity.  Gp100 plasmid DNA may elicit antibody and cytotoxic T lymphocyte (CTL) responses against melanoma cells positive for the gp100 antigen. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2563] "A vaccine consisting of microscopic gold particles coated with plasmid DNA encoding the glycoprotein 100 (gp100) melanoma antigen and granulocyte-macrophage colony-stimulating factor (GM-CSF).  Vaccination with gp100 and GM-CSF DNA/gold vaccine stimulates the host immune system to direct cytotoxic T lymphocytes (CTL) against gp100 positive cells, resulting in decreased tumor growth.  GM-CSF is thought to increase the induction and activation of antigen-presenting cells (APC), allowing for a reduction in the dose of gp100 administered. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2564] "A recombinant fowlpox virus vaccine with potential antineoplastic activity.  gp100-Fowlpox vaccine binds to melanoma antigen glycoprotein 100 (gp100) expressed by melanoma cells, thereby generating a cellular immune response to melanoma cells; this effect is enhanced by the co-administration of interleukin 2 (IL-2). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2565] "Peripheral blood lymphocytes (PBL) harvested from host blood and stimulated in vitro with tumor-specific gp 100 antigen. 'Pulsing' PBL with gp100, a tumor associated antigen (TAA) commonly expressed by melanoma cells, may increase melanoma-reactive cytotoxic lymphocytes (CTL) in the PBL cell population. Autologous gp100-pulsed PBL have been administered to melanoma patients in order to augment cytotoxic immune responses to melanoma.  (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2566] "A synthetic peptide vaccine consisting of amino acids 209 through 217 of the glycoprotein 100 (gp100) melanoma antigen that has been modified at the anchor residue to increase binding affinity.  Vaccination with gp100_ ES209-217 (210M) may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for gp100, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2567] "A peptide consisting of amino acid residues 154 through 162 of the melanoma-melanocyte antigen gp100. Vaccination with gp100:154-162 peptide may enhance tumor-specific T-cell immunity. gp100 antigen is a self-antigen expressed by melanocytes, pigmented retinal cells and most melanoma lesions. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2568] "A synthetic peptide vaccine consisting of amino acids 17 through 25 of the glycoprotein 100 (gp100) melanoma antigen.  Vaccination with gp100_17-25 may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for gp100, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2569] "A synthetic peptide vaccine consisting of the amino acids 209 through 217 of the glycoprotein 100 (gp100) melanoma antigen.  Vaccination with gp100_209-217 may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for gp100, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2570] "A vaccine consisting of the amino acids 280 through 288 of the melanoma antigen glycoprotein 100 (gp100) with potential antineoplastic activity.  Vaccination with gp100:280-288 peptide stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the gp100 antigen, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2571] "A synthetic peptide vaccine consisting of the amino acids 44 through 59 of the glycoprotein 100 (gp100) melanoma antigen.  Vaccination with gp100_44-59 may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for gp100, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2572] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2573] "A vaccine composed of lymphoma-associated proteins conjugated to keyhole limpet hemocyanin (KLH) with potential immunotherapeutic activity.  KLH-lymphoma Ig vaccine elicits an anti-idiotype T-cell and B-cell immune response in vivo and may retard tumor progression. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2574] "A synthetic peptide vaccine consisting of amino acids 26 through 35 of the melanoma differentiation antigen MART-1 with a modification at position 27 (alanine to leucine) to improve immunogenicity.  Vaccination with MART-1_26-35 (27L) stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for MART-1, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2575] "A vaccine consisting of recombinant adenovirus vector encoding MART-1 (melanoma antigen recognized by T-cells 1), an immunogenic protein of unknown function that is expressed by certain types of melanoma.  Vaccination with MART-1 adenovirus vaccine may stimulate the host immune system to direct cytotoxic T lymphocytes (CTL) against MART-1 positive melanoma cells, resulting in an antitumor effect. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2576] "A cancer vaccine consisting of an an attenuated recombinant vaccinia virus expressing the melanoma-associated antigen MART-1. Vaccination with this agent may stimulate cycotoxic host immune responses to melanoma cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2577] "A natural or synthetic peptide consisting of amino acid residues 27 through 35 of the melanoma-associated antigen MART-1 with potential use in cancer immunotherapy. Vaccination with this peptide may induce cytotoxic host immune responses to melanoma cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2578] "A synthetic cancer vaccine derived from a melanoma-associated antigen, MART-1.  Antigenic peptides derived from MART-1 are recognized by CD8+ T lymphocytes and have been used to immunize patients with advanced melanomas; prolonged immunization may result in a reduction in tumor size.  Fowlpox adenovirus is an attractive vector because its genome is easy to manipulate and it does not multiply in human tissues. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2579] "A recombinant monoclonal antibody directed against the lymphocyte receptor CD2 with potential use in cancer immunotherapy.  Activation of the CD2 molecule, one of several lymphocyte receptors, rapidly initiates signaling events regulating integrin-mediated cell adhesion. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2580] "A recombinant monoclonal antibody directed against human T-cells designed to generate cytotoxic T lymphocyte (CTL) responses to tumor antigens with potential use in cancer immunotherapy. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2581] "A conjugate of a murine immunoglobulin antibody directed against the Lewis carbohydrate epitope (B3 antigen) and a isothiocyanatobenzyl derivative (1B4M) of diethylenetriaminepentaacetic acid (DTPA) with potential use in cancer immunotherapy.  The Lewis carbohydrate epitope is present on a variety of proteins located on the surface of many different types of tumor cells and a limited number of normal tissues. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2582] "HCC49dCH2 is a humanized, domain-deleted MAb that targets the TAG-72 antigen, a mucin-like molecule expressed by colorectal adenocarcinomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2583] "Peripheral blood lymphocytes (PBL) transfected to express MOv have been designed for possible use in autologous adoptive cellular immunotherapy of ovarian adenocarcinomas that overexpress folate-binding protein. MOv-PBLs express MOv-gamma (MOv), a chimeric receptor gene product derived from a recombinant gene encoding the variable region of murine monoclonal antibody MOv18 against folate-binding protein (FBP), often overexpressed in human ovarian cancer cells, and the human gene encoding the IgG and IgE Fc receptor gamma subunit. Autologous vaccination with these PBLs stimulates a host cytotoxic T lymphocyte response against ovarian cancer cells that overexpress FBP. (NCI04)"                                                                                                                                                                                                                                                                                        
 [2584] "A vaccine consisting of myeloma-specific immunoglobulin conjugated to keyhole limpet hemocyanin (KLH), an immune stimulant, with potential antineoplastic activity.  Vaccination with myeloma Ig Id-KLH conjugate vaccine stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against myeloma cells, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2585] "A cancer vaccine consisting of a mixture of a murine lymphoma-derived idiotype and interleukin-2 (IL-2) encapsulated in dimyristoylphosphatidylcholine liposomes.  The use of a liposomal carrier confers immunogenicity to the naturally non-immunogenic idiotype. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2586] "A synthetic peptide derived from the tumor suppressor protein p53 with potential use in cancer immunotherapy.  p53:264-272 peptide consists of amino acid residues 264 through 272 of the p53 protein. Vaccination with this agent may induce a cytotoxic host immune response to tumor cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2587] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2588] "A synthetic peptide immunogen of HIV envelope. It may cause increases in HIV peptide-specific immune responses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2589] "A synthetic peptide immunogen of HIV envelope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2590] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2591] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2592] "A preparation of T lymphocytes harvested from a patient with cancer and transduced with the PG13/Lnc8 retroviral vector, a clone of the LN vector that encodes the neomycin phosphotransferase gene.  The modified T lymphocytes are cloned using an ex vivo technique and infused back into the patient, where they may elicit a host immune response against tumor cells.  The neomycin phosphotransferase gene product has no direct therapeutic value; it serves as a molecular marker to monitor the presence and localization of the PG13/Lnc8-transduced T-lymphocytes in the host. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                 
 [2593] "A plasmid vector encoding interleukin-12 (IL-12) with potential use in the gene therapy of cancer.  pNGVL3-hIL12 may induce a high level of IL-12 protein expression during transient transfection of host cells.  IL-12 is a proinflammatory cytokine with numerous immunoregulatory functions and may augment host immune responses to tumor cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2594] "A truncated synthetic form of the oncogene Ras, whose protein product p21 is located in the plasma membrane and transduces growth and differentiation signals from activated receptors to protein kinases within the cell.  Because mutated Ras proteins may represent highly specific epitopes for T-cell recognition, PR18 (ras-13 Cys) peptide may be used in the vaccine immunotherapy of cancer. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2595] "A synthetic form of the ras peptide containing a point mutation at position 13 (glycine to asparagine). Vaccines using mutant ras peptides may be used in the immunotherapy of various cancers that express ras mutations. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2596] "A synthetic form of the ras peptide containing a point mutation at position 12 (glycine to valine). Vaccines using mutant ras peptides may be used in the immunotherapy of various cancers that express ras mutations. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2597] "A truncated synthetic form of the oncogene Ras, whose protein product p21 is located in the plasma membrane and transduces growth and differentiation signals from activated receptors to protein kinases within the cell.  Because mutated Ras proteins may represent highly specific epitopes for T-cell recognition, PR6V10 (ras-12 Asp) peptide may be used in the vaccine immunotherapy of cancer. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2598] "A natural or synthetic peptide derived from the Ras protein with potential use in cancer immunotherapy. Ras protein regulates a number of signalling molecules by translocating them to the plasma membrane for activation and may serve as a branchpoint in signal transduction because it orchestrates the activity of multiple signalling pathways to regulate diverse cellular functions. Ras-12 Ala is a mutated form of the wild-type Ras protein in which the amino acid glycine at codon 12 is replaced with alanine. Vaccination with mutated Ras proteins or peptides may stimulate cytotoxic host immune responses to tumor cells that express similarly mutated Ras proteins. (NCI04)"                                                                                                                                                                                                                                                                                                  
 [2599] "A 9 amino acid peptide that derived from an azurophil granule protein called proteinase 3.  The synthetic ally produced PR1 peptide is being used with incomplete Freund's adjuvant to vaccinate patients with myeloid leukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2600] "A natural or synthetic peptide consisting of nine amino acids derived from the prostate-specific self-antigen (PSA).  PSA-3 peptide may exhibit greater immunostimulant activity than PSA. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2601] "An oncolytic virus that is a replication-competent strain of the Newcastle disease virus.  PV701 has been in clinical trials for intraperitoneal malignancies and bladder cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2602] "An antisense oligonucleotide targeting the mRNA of either PAX3 or FKHR gene of the chimeric PAX3/FKHR fusion gene, a transcriptional activator, inducing apoptosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2603] "A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called histone deacetylase inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2604] "A synthetic form of the ras peptide containing a point mutation at position 12 (glycine to aspartic acid) with potential antineoplastic activity.  Vaccination with ras peptide Asp may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for this ras mutation, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2605] "A synthetic form of the ras peptide containing a point mutation at position 12 (glycine to cysteine) with potential antineoplastic activity.  Vaccination with ras peptide Cys stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for this ras mutation, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2606] "A synthetic form of the ras peptide containing a point mutation at position 12 (glycine to valine) with potential antineoplastic activity.  Vaccination with ras peptide Val stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for this ras mutation, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2607] "A vaccine consisting of a replication-defective recombinant fowlpox virus that encodes for the murine melanoma antigen glycoprotein 100 (mgp100) with potential antineoplastic activity.  Vaccination with recombinant fowlpox-mgp100 vaccine stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the gp100 antigen, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2608] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2609] "A recombinant fowlpox virus vaccine with potential antineoplastic activity.  Binding to the melanoma antigen tyrosinase, the fowlpox-tyrosinase vaccine generates cellular immune responses against melanoma cells expressing the tyrosinase antigen; this effect is enhanced by the co-administration of interleukin 2 (IL-2). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2610] "A recombinant agent which is chemically identical to or similar to the endogenous cytokine interleukin 4 (IL-4) with potential antineoplastic activity.  Recombinant IL-4 may induce cytotoxic T lymphocyte (CTL) activity, thereby increasing the cytotoxic host immune response against tumor cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2611] "A recombinant vaccinia virus encoding carcinoembryonic antigen (CEA). CEA is overexpressed in several cancer cell types, including gastrointestinal, breast, and non-small cell lung cancers. Attenuated vaccinia virus is a highly effective immunizing agent that evokes both humoral and cell-mediated responses.  Vaccination with this agent may evoke a cyctotoxic immune response to CEA-expressing cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2612] "A proprietary oil-in-water emulsion specifically designed for combining protein preparations used in vaccines.  SB-AS02B adjuvant contains monophosphoryl lipid A and QS21, a saponin extracted from the South American tree Quillaja Saponaria Molina. This agent may be used for formulating cancer-specific vaccine preparations such as those containing MAGE-3 melanoma protein. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2613] "A recombinant chimeric protein composed of the heat shock protein 65 (Hsp65) from Mycobacterium bovis, and the human papilloma viral (HPV) protein E7.  Hsp65, similar to other members of its family of proteins, elicits a strong immune response and may be used to design vaccines against a number of different cancers.  E7 protein is involved in carcinogenesis of anal and cervical tumors, and represents a tumor antigen that may be specifically targeted by lymphocytes. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2614] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2615] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2616] "A vaccine that contains detoxified tetanus toxin of Clostridium tetani. Aluminum phosphate is an adjunct that adsorbs the tetanus antigens to increase the half-life and immunogenicity of the vaccine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2617] "A recombinant peptide consisting of amino acid residues 180 to 188 of the tyrosinase-related protein 2 (TRP2).  Expressed by cells of melanocyte origin, TRP2 is an enzyme involved in the process that converts tyrosinase to melanin pigments. Vaccination with TRP-2: 180-188 peptide may induce cytotoxic T lymphocyte (CTL) responses to melanoma cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2618] "A recombinant peptide consisting of amino acid residues 1 to 9 of the tyrosinase-related protein 1 (TRP1).  Expressed by cells of melanoctye origin, TRP1 is an enzyme involved in the process that converts tyrosinase to melanin pigments. Vaccination with TRP1(0RF3):1-9 may stimulate cytotoxic T cell responses to melanoma cells.. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2619] "A mixture of allogeneic or autologous tumor cells and bacillus Calmette-Guerin (BCG) in a liquid vehicle with potential antineoplastic activity.  Vaccination of the host with tumor cell vaccine plus BCG may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against similar host tumor cells, resulting in decreased tumor growth. The BCG component serves as an adjuvant, a nonspecific stimulator of the immune response. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2620] "A synthetic peptide vaccine consisting of amino acids 206 through 214 of the melanoma-associated antigen tyrosinase.  Vaccination with TYROSINASE_206-214 may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for tyrosinase, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2621] "A recombinant peptide consisting of amino acid residues 240 to 251 of the enzyme tyrosinase, a protein frequently expressed by melanoma cells.  Vaccination with this agent may stimulate cytotoxic T lymphocytes and class II MHC-restricted melanoma-reactive CD4+ T cells to target tyrosinase-expressing tumor cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2622] "A synthetic peptide consisting of amino acids 368 through 376 of the melanoma-associated antigen tyrosinase with a modification at position 370 to increase binding affinity.  Vaccination with TYROSINASE:368-376(370D) may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for tyrosinase, thereby decreasing tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2623] "A vaccine consisting of lymphoma-specific immunoglobulin that is not conjugated to a carrier molecule.  Vaccination with unconjugated lymphoma Ig Id stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against lymphoma cells, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2624] "A vaccine consisting of myeloma-specific immunoglobulin that is not conjugated to a carrier molecule.  Vaccination with unconjugated myeloma Ig Id stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against myeloma cells, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2625] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2626] "A peptide vaccine derived from the von Hippel-Lindau (VHL) tumor suppressor protein, a general transcription factor.  VHL2 (Y12M) peptide is a point mutation variant (from tyrosine to methionine) of the VHL protein.  It might be used to elicit or boost cellular immunity to cancers that expressing the von Hippel-Lindau mutation. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2627] "A quinoxaline phenoxypropionic acid derivative with antineoplastic properties.  XK469R selectively inhibits topoisomerase II by stabilizing the enzyme-DNA intermediates in which topoisomerase subunits are covalently linked to DNA through 5-phosphotyrosyl linkages, thereby interfering with DNA repair and replication, RNA and protein synthesis.  This agent possesses unusual solid tumor selectivity and activity against multidrug-resistant cancer cells.  'R' designates the racemic form of the compound, which is more water soluble and active than the pure isomers. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                      
 [2628] "An agent that inhibits the telomerase, a ribonucleoprotein enzyme that adds telomeric sequences to the 3-ends of eukaryotic chromosomes, thus permitting proliferation of immortal cells beyond the limits of cellular senescence.  Telomerase is active in most tumors cells, but is quiescent in adjacent normal cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2629] "The hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility.  This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2630] "An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASE I. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2631] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2632] "A modified cold virus that selectively grows in and destroys certain types of cancer cells and leaves normal cells undamaged."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2633] "A simple sugar monosaccharide having two isoforms, alpha and beta, with a chemical structure of C6H12O6 that acts as an energy source for both plants and animals by reacting with oxygen to form Carbon Dioxide and Water, releasing energy.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2634] "A naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.  Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acids), d-alpha-Tocopherol is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production.  Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                
 [2635] "The amino acid methionine with selenium substituting for the sulphur moiety.  Methionine is an essential amino acid in humans, whereas selenium is a free-radical scavenging anti-oxidant, essential for the protection of various tissues from the damages of lipid peroxidation.  As a trace mineral that is toxic in high doses, selenium is a cofactor for glutathione peroxidase, an anti-oxidant enzyme that neutralizes hydrogen peroxide.  L-Selenomethionine is considered a safe, efficacious form of selenium and is readily bioavailable.  Selenium may be chemoprotective for certain cancers, particularly prostate cancer. (NCI04)"                                                                                                                                                                                                                                                                                                                                                  
 [2636] "The acetate ester of a fat-soluble vitamin with potent antioxidant properties.  Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acid), vitamin E is a generic name for a group of compounds known as tocopherols and tocotrienols (tocols).  This agent is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production.  Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. (NCI04)"                                                                                                                                                                                                                                                                                                                                       
 [2637] "A vaccine component consisting of a protein, small peptide, or polysaccharide, natural or synthetic, that once administered is bound by antibody, thereby inducing mechanisms of antibody-dependent cell-mediated cytotoxicity (ADCC).  In cancer immunotherapy, a cancer vaccine containing specific tumor-associated antigens (TAAs) may be used to boost an immune response against a tumor expressing those TAAs. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2638] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2639] "A recombinant cancer vaccine consisting of a fowlpox adenovirus vector encoding the prostate-specific antigen (PSA). This agent stimulates cytotoxic T-lymphocytes to target PSA-expressing tumor cells. The fowlpox adenovirus vector is easily manipulated and does not multiply in human tissues. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2640] "A recombinant fowlpox adenovirus vector encoding human B7.1 (CD80 antigen), a T-cell costimulatory molecule.  Recombinant Fowlpox-B7.1 may be used as a vaccine vector; incorporating the B7-1 gene into this vector may enhance the presentation of fowlpox virus vector-encoded tumor antigens to antigen presenting cells (APC) and activate cytotoxic T-cells against tumor antigen-expressing tumors. The fowlpox adenovirus vector is easily manipulated and does not multiply in human tissues. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2641] "A recombinant virus-based vaccine that contains various peptide antigens.  Fowlpox adenovirus is an attractive vector because its genome is easy to manipulate and it does not multiply in human tissues.  Strong CD8 T cell responses may be induced after prolonged immunization and have been associated with tumor regression. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2642] "A recombinant vaccinia virus encoding the T-cell co-stimulatory molecule B7-1. Co-administration of recombinant vaccinia-B7.1 and a tumor-associated antigen in a cancer vaccine enhances tumor-associated antigen-specific T-cell responses. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2643] "A class of vaccines with potential antineoplastic activity.  Peripheral blood lymphocytes (PBL) are first harvested from a cancer patient and induced to express a particular tumor-associated antigen or multiple antigens.  Autologous vaccination with activated PBL stimulates the host immune system to produce antibodies and/or mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the antigen(s), resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2644] "DNA binding molecules regulate mechanisms central to cellular function, including DNA replication and gene expression. Many small molecules that mimic or block these processes offer potential therapeutic agents. Understanding how complexation affects both the structural and mechanical properties of DNA is an important step towards understanding the functional mechanisms of binding agents, and may also provide a key to more rational drug design. There are three major classes of binding modes: intercalation, groove binding and covalent crosslinking."                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2645] "An anticancer drug related in structure to camptothecin, a topoisomerase inhibitor. One such drug is aminocamptothecin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2646] "A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces chrysomallus.  Actinomycin F1 intercalates into the minor groove of DNA and binds to topoisomerase II, leading to the inhibition of DNA replication and RNA and protein synthesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2647] "The DNA found between nucleosomes on chromatin; since it is not complexed to proteins as strongly as other forms of DNA, it is accessible to exonuclease hydrolysis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2648] "A class of agents that reversibly inhibit the membrane-bound intestinal glucosidases (usually alpha glucosidases), enzymes that hydrolyze complex sugars into glucose in the intestines, thereby delaying the metabolism of dietary carbohydrates and reducing postprandial plasma glucose.  A glucosidase inhibitor is often structurally similar to glucose. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2649] "There are two mesothoriums produced in thorium decay. Mesothorium I is an isotope of radium; mesothorium II is an isotope of actinium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2650] "A vaccine which will result in protection to several, closely related, agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2651] "RAEB: Refers to any abnormality, anatomical or biochemical, evident at birth or during the neonatal period."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2652] "(a-klor-HY-dree-a) A lack of hydrochloric acid in the digestive juices in the stomach. Hydrochloric acid helps digest food."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2653] "A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes; opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis); and the development of malignant neoplasms (usually non-Hodgkin's lymphoma and Kaposi's sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood. Generalized lymphadenopathy, fever, weight loss, and chronic diarrhea are common symptoms of AIDS. The patients usually die either of opportunistic infections or malignant neoplasms. -- 2004"                                                                                                                                                  
 [2654] "(AD-in-o-kar-sin-O-ma) Cancer that begins in cells that line certain internal organs and that have glandular (secretory) properties."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2655] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2656] "An adenoma characterized by an oncocytic, often papillary, epithelial component, dense lymphoid stroma, and cystic spaces. It occurs primarily in the parotid gland, and is the second most common benign parotid salivary gland tumor. A strong association with smoking has been reported. About 10% develop simultaneous or metachronous contralateral tumors.  It typically presents as a painless swelling in the lower portion of the parotid gland. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2657] "(ad-in-O-ma) A noncancerous tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2658] "Pituitary adenomas comprise approximately 10% of intracranial neoplasms.  Pituitary may be classified on the basis of their anatomical, histological or functional characteristics.  Histologically pituitary tumors are divided into acidophilic, basophilic and chromophobe adenomas on the basis of conventional staining techniques. -2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2659] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2660] "A benign or malignant (primary or metastatic) neoplasm of the adrenal cortex. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2661] "A tumor of the adrenal glands, either benign or malignant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2662] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2663] "An unwanted effect caused by a drug or therapy.  Such effects can be drug related, dose related, route related, patient related, caused by an interaction with another drug, or caused by opioid initiation or dose escalation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2664] "A chronic myeloproliferative disorder characterized by bone marrow fibrosis, proliferation of atypical megakaryocytes (micromegakaryocytes) and granulocytes in the bone marrow, anemia, splenomegaly, and extramedullary hematopoiesis.  The cause is unknown.  The median survival time is 3-5 years from diagnosis. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2665] "A decrease in the number of mature granulocytes (neutrophils, eosinophils, and basophils) in the peripheral blood. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2666] "neurological complications characterized by abnormalities in cognition, motor performance, and behavior due to HIV infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2667] "(al-oh-PEE-shuh) The lack or loss of hair from areas of the body where hair is usually found. Alopecia can be a side effect of some cancer treatments."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2668] "A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2669] "Systematic and extensive loss of memory caused by organic or psychological factors. The loss may be temporary or permanent, and may involve old or recent memories."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2670] "A group of diseases in which protein is deposited in specific organs (localized amyloidosis) or throughout the body (systemic amyloidosis). Amyloidosis may be either primary (with no known cause) or secondary (caused by another disease, including some types of cancer). Generally, primary amyloidosis affects the nerves, skin, tongue, joints, heart, and liver; secondary amyloidosis often affects the spleen, kidneys, liver, and adrenal glands."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2671] "(a-NEE-mee-a) A condition in which the number of red blood cells is below normal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2672] "A condition in which the bone marrow is unable to produce blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2673] "(per-NISH-us a-NEE-mee-a) A type of anemia (low red blood cell count) caused by the body's inability to absorb vitamin B12."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2674] "A myelodysplastic syndrome characterized mainly by dysplasia of the erythroid series.  Refractory anemia is uncommon.  It is primarily a disease of older adults.  The median survival exceeds 5 years.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2675] "A chromosomal abnormality in which there is an addition or loss of chromosomes within a set (e.g., 23 + 22 or 23 + 24)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2676] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2677] "An abnormal loss of the appetite for food.  Anorexia can be caused by cancer, AIDS, a mental disorder (i.e., anorexia nervosa), or other diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2678] "Absence or reduction of oxygen in body tissue. (PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2679] "An abnormal growth of cells at or near the anus"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2680] "general term for the group of specific, anxiety-related, avoidance- prone disorders listed as NTs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2681] "APUD is an acronym which means: amine precursor uptake and decarboxylation.  Apudoma is a tumor made up of cells with APUD properties. - 2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2682] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2683] "Arrhythmia; an abnormal rate of muscle contractions in the heart."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2684] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2685] "A disease marked by inflammation and pain in the joints."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2686] "A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2687] "(ah-SYE-teez) Abnormal buildup of fluid in the abdomen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2688] "An infectious fungal disease that occurs most often in the skin, ears, nasal sinuses, and lungs of people with suppressed immune systems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2689] "Rare hereditary disease characterized by extreme sensitivity to ionizing radiation or radiomimetic drugs because of a defect in DNA repair. AT heterozygosity is estimated to occur in more than 2% of the U.S. population; heterozygotes exhibit increased radiation sensitivity and are at increased risk for several types of cancer. The normal version of the gene that is defective in AT appears to activate the p53-dependent response to DNA damage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2690] "(at-uh-LEK-tuh-sis) Failure of the lung to expand (inflate) completely. This may be caused by a blocked airway, a tumor, general anesthesia, pneumonia or other lung infections, lung disease, or long-term bedrest with shallow breathing.  Sometimes called a collapsed lung."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2691] "A condition in which the body recognizes its own tissues as foreign and directs an immune response against them."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2692] "infections and associated diseases by bacteria, general or unspecified."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2693] "A condition in which the cells lining the lower part of the esophagus have changed or been replaced with abnormal cells that could lead to cancer of the esophagus. The backing up of stomach contents (reflux) may irritate the esophagus and, over time, cause Barrett's esophagus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2694] "An inherited condition that causes unusual facial features and disorders of the skin, bone, nervous system, eyes, and endocrine glands. People with this syndrome have an increased chance of developing basal cell carcinoma. Also called Gorlin syndrome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2695] "broad class of abnormalities of thought, feeling, and behavior, resulting in distress or impairment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2696] "This is a non-cancerous growth of tissue originating in the colon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2697] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2698] "Abnormal growth of the cells that comprise the tissues of the skin, without any evidence of malignancy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2699] "(hye-per-PLAY-zha) BPH. A benign (noncancerous) condition in which an overgrowth of prostate tissue pushes against the urethra and the bladder, blocking the flow of urine. Also called benign prostatic hypertrophy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2700] "Benign and malignant neoplasms which form in the biliary tree, which includes the bile ducts and gall bladder. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2701] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2702] "A non-neoplastic or neoplastic disorder affecting the urinary bladder.  A representative example of non-neoplastic bladder disorder is bacterial bladder infection.  A representative example of neoplastic bladder disorder is bladder carcinoma. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2703] "A benign or malignant, primary or metastatic neoplasm of the bladder. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2704] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2705] "Bloom syndrome is an autosomal recessive disorder associated with mutations in BLM gene encoding protein that belongs to the family of DNA helicases. It is characterized by predisposition to cancer, immunodeficiency, high sensitivity to UV and genomic instability of somatic cells. (Oncogene 2001 Dec 13;20(57):8276-80)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2706] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2707] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2708] "(BO-uns disease) A skin disease marked by scaly or thickened patches on the skin and often caused by prolonged exposure to arsenic.  The patches often occur on sun-exposed areas of the skin and in older, white men.  These patches may become malignant (cancerous).  Also called precancerous dermatosis or precancerous dermatitis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2709] "Benign and malignant neoplasms that arise from or metastasize to structures within the cranium.  This includes meningeal and other tumors that occur in the spaces that surround the brain, and neoplasms of the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2710] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2711] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2712] "A benign or malignant neoplasm of the breast parenchyma.  It can originate from the ducts, lobules or the breast adipose tissue.  Breast neoplasms are much more common in females than males. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2713] "(bron-KYE-tis) Inflammation (swelling and reddening) of the bronchi."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2714] "A highly aggressive lymphoma composed of monomorphic medium-sized B-cells with basophilic cytoplasm and numerous mitotic figures.  It is often associated with the presence of Epstein-Barr virus (EBV) and is commonly seen in AIDS patients.  Three morphologic variants are recognized: classical Burkitt's lymphoma, Burkitt's lymphoma with plasmacytoid differentiation, and atypical Burkitt's/Burkitt's-like lymphoma.  All cases express the MYC translocation [t(8;14)]. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2715] "The loss of body weight and muscle mass frequently seen in patients with cancer, AIDS, or other diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2716] "Infection of the vulva and vagina with a fungus of the genus CANDIDA.  It is a disease associated with HIV infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2717] "(KAR-sin-oyd) A type of tumor usually found in the gastrointestinal system (most often in the appendix), and sometimes in the lungs or other sites.  Carcinoid tumors are usually benign."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2718] "(ep-ih-THEE-lee-ul kar-sin-O-ma) Cancer that begins in the cells that line an organ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2719] "(kar-sin-O-ma in SYE-too) Cancer that involves only the cells in which it began and that has not spread to neighboring tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2720] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2721] "Prostate adenocarcinoma is one of the most common malignant tumors afflicting men.  The majority of adenocarcinomas arise in the peripheral zone and a minority occur in the central or the transitional zone of the prostate gland.  Grading of prostatic adenocarcinoma predicts disease progression and correlates with survival.  Several grading systems have been proposed, of which the Gleason system is the most commonly used.  Gleason sums of 2 to 4 represent well-differentiated disease, 5 to 7 moderately differentiated disease and 8 to 10 poorly differentiated disease.  Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic adenocarcinoma.  Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy.  Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease. --2002"                                       
 [2722] "A primary or metastatic tumor involving the skin.  Primary malignant skin tumors most often are carcinomas (either basal cell or squamous cell carcinomas that arise from cells in the epidermis) or melanomas that arise from pigment-containing skin melanocytes.  Metastatic tumors to the skin include carcinomas and lymphomas. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2723] "(BAY-sal sel kar-sin-O-ma) A type of skin cancer that arises from the basal cells, small round cells found in the lower part (or base) of the epidermis, the outer layer of the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2724] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2725] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2726] "(DUK-tal kar-sin-O-ma in SYE-too) DCIS. Abnormal cells that involve only the lining of a duct. The cells have not spread outside the duct to other tissues in the breast. Also called intraductal carcinoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2727] "A group of at least three distinct histological types of lung cancer, including squamous cell carcinoma, adenocarcinoma, and large cell carcinoma.  Non-small cell lung carcinomas have a poor response to conventional chemotherapy.  --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2728] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2729] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2730] "(SKWAY-mus sel kar-sin-O-ma) Cancer that begins in squamous cells, which are thin, flat cells that look like fish scales. Squamous cells are found in the tissue that forms the surface of the skin, the lining of the hollow organs of the body, and the passages of the respiratory and digestive tracts. Also called epidermoid carcinoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2731] "A malignant neoplasm arising from the transitional epithelium, usually affecting the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary configuration. It is graded 1 to 3 or 4 according to the degree of cellular differentiation and architectural patterns. Grade 1 transitional cell carcinoma is histologically benign but it may recur. Transitional cell carcinomas may also affect the upper respiratory tract and the ovaries. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2732] "A non-neoplastic or neoplastic disorder affecting the heart or the vessels (arteries, veins and lymph vessels).  Representative examples of non-neoplastic cardiovascular disorders are endocarditis and hypertension.  Representative examples of neoplastic cardiovascular disorders are endocardial myxoma and angiosarcoma. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2733] "Usually encapsulated and benign, but estimated malignancy rates of 2 - 25%."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2734] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2735] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2736] "A benign or malignant (primary or metastatic) tumor involving the cerebellum. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2737] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2738] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2739] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2740] "A polyp that arises from the glandular epithelium of the cervix. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2741] "Abnormal growth in the cervix, which can be benign (non cancerous) or malignant (cancerous )"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2742] "A rare autosomal recessive immunodeficiency disorder characterized by abnormal intracellular protein transport. Chediak-Higashi syndrome (CHS) is characterized by immune deficiency; partial oculocutaneous albinism; a bleeding disorder due to deficient platelet dense bodies; neutropenia; neutrophils with impaired chemotaxis and bactericidal activity; recurrent infection; and abnormal natural killer (NK) cell function. CHS may be associated with hepatosplenomegaly, lymphadenopathy, anemia, thrombocytopenia, roentgenologic changes in bones, lungs and heart, and skin and psychomotor abnormalities; it is often fatal in childhood as a result of infection or an accelerated lymphoma-like phase. CHS occurs in mink, cattle, and mice, as well as man. --2004"                                                                                                                                                                                                               
 [2743] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2744] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2745] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2746] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2747] "(KAHN-dro-sar-KO-ma) A type of cancer that forms in cartilage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2748] "(kor-DO-ma) A type of bone cancer that usually starts in the lower spinal cord."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2749] "A rare cancer in women of childbearing age in which cancer cells grow in the tissues that are formed in the uterus after conception. Also called gestational trophoblastic disease, gestational trophoblastic neoplasia, gestational trophoblastic tumor, or molar pregnancy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2750] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2751] "An irregularity in the number or structure of chromosomes, usually in the form of a gain (duplication), loss (deletion), exchange (translocation), or alteration in sequence (inversion) of genetic material."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2752] "A type of chronic, progressive liver disease in which liver cells are replaced by scar tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2753] "Chronic inflammation of the colon that produces ulcers in its lining.  This condition is marked by abdominal pain, cramps, and loose discharges of pus, blood, and mucus from the bowel."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2754] "A benign or malignant tumor involving the colon. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2755] "Abnormal growths of tissue in the lining of the bowel.  Polyps are a risk factor for colon cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2756] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2757] "Benign or malignant abnormal growth in the colon or rectum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2758] "A disorder characterized by an individual's inability to comprehend or share ideas or feelings because of an impairment in language, speech, or hearing. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2759] "Complication; any disease or disorder that occurs during the course of (or because of) another disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2760] "(kahn-dih-LO-ma-ta a-kyoo-mih-NA-ta) Genital warts caused by certain human papillomaviruses (HPVs)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2761] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2762] "(SEE-zhurz) Convulsions; sudden, involuntary movements of the muscles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2763] "Abnormal growth of the cells that comprise the cranial nerves."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2764] "(KRAY-nee-o-fah-rin-jee-O-ma) A benign brain tumor that may be considered malignant because it can damage the hypothalamus, the area of the brain that controls body temperature, hunger, and thirst."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2765] "A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn's disease most commonly involves the terminal ileum; the colon is the second most common site of involvement. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2766] "An acute or chronic, localized or disseminated infection by Cryptococcus neoformans.  Sites of involvement include the lungs, central nervous system and meninges, skin, and visceral organs.--2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2767] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2768] "A malignant tumor arising from the epithelial cells, also known as cylindroma.  Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma).  Adenoid cystic carcinomas mostly occur in the salivary glands.  Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs.  Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur.  Lymph node metastases are unusual; hematogenous tumor spread is characteristic. -- 2004"                                                                                                                                                                                                                                                                
 [2769] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2770] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2771] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2772] "A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed) (MSH2000)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2773] "A common hereditary disease in which exocrine (secretory) glands produce abnormally thick mucus. This mucus can cause problems in digestion, breathing, and body cooling."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2774] "An autosomal recessive hereditary disorder characterized by defective transportation of cystine across the lysosomal membranes and systemic deposition of cystine crystals in the body.  It is associated with slight increase of the plasma cystine, cystinuria, aminoaciduria, glycosuria, polyuria, hypophosphatemia, rickets, and renal tubular dysfunction. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2775] "A type of tumor found in breast tissue.  It is often large and bulky and grows quickly. It is usually benign (not cancer), but may be malignant (cancer). Also called cystosarcoma phyllodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2776] "(sist) A sac or capsule filled with fluid."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2777] "A reduction in the number of blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2778] "Difficulty swallowing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2779] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2780] "Depression; a mental state of depressed mood characterised by feelings of sadness, despair and discouragement. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2781] "Inflammation of the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2782] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2783] "(MEL-ih-tus) A group of disorders in which there is a defect in the transfer of glucose (sugar) from the bloodstream into cells, leading to abnormally high levels of blood sugar (hyperglycemia)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2784] "Diabetes mellitus characterized by insulin deficiency, sudden onset, severe hyperglycemia, rapid progression to ketoacidosis, and death unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2785] "Diarrhea; a condition of frequent and watery bowel movements."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2786] "a congenital anomaly characterized by immunodeficiency, abnormal facies, congenital heart disease, hypocalcemia, and increased susceptibility to infections. Pathologic characteristics include conotruncal abnormalities and absence or hypoplasia of thymus and parathyroid glands. DiGeorge syndrome is associated with abnormalities of chromosome 22. Also known as DiGeorge anomaly. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2787] "RAEB: Diseases of the digestive tract (oral cavity to anus) and associated organs (salivary glands, liver, pancreas)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2788] "A disease is any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. Sometimes the term is used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2789] "Disseminated intravascular coagulation (DIC) is a pathological process in the body where the blood starts to coagulate throughout the whole body. This depletes the body of its platelets and coagulation factors, and there is an increased the risk of hemorrhage.  There are a variety of causes of DIC, all usually causing the release of chemicals into the blood that instigates the coagulation. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2790] "A chromosomal dysgenesis syndrome resulting from a triplication or translocation of chromosome 21. Down syndrome occurs in approximately 1:700 live births. Abnormalities are variable from individual to individual and may include mental retardation, retarded growth, flat hypoplastic face with short nose, prominent epicanthic skin folds, small low-set ears with prominent antihelix, fissured and thickened tongue, laxness of joint ligaments, pelvic dysplasia, broad hands and feet, stubby fingers, transverse palmar crease, lenticular opacities and heart disease. Patients with Down syndrome have an estimated 10 to 30-fold increased risk for leukemia; most have symptoms of Alzheimer's disease by age 40. Also known as trisomy 21 syndrome. --2004"                                                                                                                                                                                                                        
 [2791] "A group of symptoms that occur when food or liquid enters the small intestine too rapidly. These symptoms include cramps, nausea, diarrhea, and dizziness. Dumping syndrome sometimes occurs in people who have had a portion of their stomach removed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2792] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2793] "Dysgerminoma arises primarily in the ovaries, but can occur both primarily and secondarily at other sites, particularly CNS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2794] "Painful or difficult coitus. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2795] "Difficult, painful breathing or shortness of breath."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2796] "Difficulty or pain in urination."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2797] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2798] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2799] "(eh-DEE-ma) Swelling caused by excess fluid in body tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2800] "A collection of fluid in a body cavity.  It may be the result of a non-neoplastic disorder (e.g. heart failure) or a tumor (e.g. carcinoma of the lung). -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2801] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2802] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2803] "An autoimmune demyelinating disease of the central nervous system that is produced experimentally in animals by the injection of homogenised brain or spinal cord in Freund's adjuvant. Myelin basic protein appears to be the antigen that elicits the hypersensitivity immune response which is characterized by focal areas of lymphocyte and macrophage infiltration into the brain, associated with demyelination and destruction of the blood-brain barrier. Experimental allergic encephalomyelitis (EAE) is used as an animal model for demyelinating diseases of the human central nervous system such as multiple sclerosis. --2004"                                                                                                                                                                                                                                                                                                                                                      
 [2804] "(en-kon-DRO-ma) A benign (noncancerous) growth of cartilage in bones or in other areas where cartilage is not normally found."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2805] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2806] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2807] "A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2808] "This is the most common malignant germ cell tumor in the pediatric population. Yolk sac tumors arise in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum. - 2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2809] "Tumor originating and limited to the endometrium at first stage"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2810] "A proliferation of the endometrial cells resulting in glandular enlargement and budding.  The proliferation may or may not be associated with atypia of the endometrial cells.  When the hyperplastic changes are excessive, there is formation of complex epithelial structures (complex endometrial hyperplasia). --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2811] "(en-do-mee-tree-O-sis) A benign condition in which tissue that looks like endometrial tissue grows in abnormal places in the abdomen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2812] "A condition in which the number of eosinophils (a type of white blood cell) in the blood is greatly increased. Eosinophilia is often a response to infection or allergens (substances that cause an allergic response)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2813] "A clinical variant of Langerhans cell histiocytosis characterised by unifocal involvement of a bone (most often), skin, or lung.  Patients are usually older children or adults usually presenting with a lytic bone lesion.  The etiology is unknown.  Morphologically, eosinophilic granuloma is characterised by the presence of Langerhans cells in a characteristic milieu which includes histiocytes, eosinophiles neutrophiles, and small, mature lymphocytes. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2814] "(ep-en-dih-MOE-mah) A type of brain tumor that may arise in the ventricles of the brain or in the spinal cord. Also called an ependymal tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2815] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2816] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2817] "A group of disorders marked by problems in the normal functioning of the brain.  These problems can produce seizures, unusual body movements, a loss of consciousness or changes in consciousness, as well as mental problems or problems with the senses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2818] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2819] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2820] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2821] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2822] "(eh-RITH-ro-PLAY-kee-a) A reddened patch with a velvety surface found in the mouth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2823] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2824] "(eh-SOF-a-JEE-al) Having to do with the esophagus, the muscular tube through which food passes from the throat to the stomach."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2825] "Abnormal growth of the cells of the esophagus, without specification as to whether the cells are benign or have malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2826] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2827] "Abnormal growth of the cells that comprise the structures of the eye"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2828] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2829] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2830] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2831] "A rare and often fatal inherited disease in which the bone marrow fails to produce red blood cells, white blood cells, platelets, or a combination of these cells. The disease may transform into myelodysplastic syndrome or leukemia.  Also called Fanconi anemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2832] "A rare and often fatal inherited disease in which the bone marrow fails to produce red blood cells, white blood cells, platelets, or a combination of these cells. The disease may transform into myelodysplastic syndrome or leukemia.  Also called Fanconi's syndrome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2833] "Fatigue is that state, following a period of mental or bodily activity, characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness, sleepiness, or irritability. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2834] "A syndrome of unknown etiology. Chronic fatigue syndrome (CFS) is a clinical diagnosis characterized by an unexplained persistent or relapsing chronic fatigue that is of at least six months' duration, is not the result of ongoing exertion, is not substantially alleviated by rest, and results in substantial reduction of previous levels of occupational, educational, social, or personal activities. Common concurrent symptoms of at least six months duration include impairment of memory or concentration, diffuse pain, sore throat, tender lymph nodes, headaches of a new type, pattern, or severity, and nonrestorative sleep. The etiology of CFS may be viral or immunologic. Neurasthenia and fibromyalgia may represent related disorders. Also known as myalgic encephalomyelitis. --2004"                                                                                                                                                                                   
 [2835] "Fever, also known as pyrexia, is the elevation of the body's temperature above the upper limit of normal, usually taken as 37.7 degrees C.  Most fevers are caused by infections and almost all infectious diseases cause fever. (Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2836] "Fibrosis associated with cyst formation in the breast parenchyma. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2837] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2838] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2839] "A condition in which multiple fibromas develop.  Fibromas are tumors (usually benign) that affect connective tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2840] "A malignant mesenchymal tumor composed of fibroblasts, and characterized by collagen production and a herringbone architectural pattern.  Fibrosarcomas are classified as adult or infantile.  Infantile fibrosarcomas generally have a much more favorable prognosis than adult fibrosarcomas. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2841] "The growth of fibrous tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2842] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2843] "A traumatic injury to the bone in which the continuity of the bone is broken. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2844] "A broken bone caused by disease, often by the spread of cancer to the bone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2845] "Abnormal growth of the cells that comprise the gall bladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2846] "A benign neuroblastic tumor of the sympathetic nervous system that occurs in childhood. Ganglioneuroma typically arises from the sympathetic trunk in the mediastinum. Histologic features include spindle cell proliferation (resembling a neurofibroma) and the presence of large ganglion cells. Common presenting features include a palpable abdominal mass, hepatomegaly, and a thoracic mass detected on routine chest X-ray. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2847] "(gas-tri-NO-ma) A tumor that causes overproduction of gastric acid.  It usually occurs in the islet cells of the pancreas but may also occur in the esophagus, stomach, spleen, or lymph nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2848] "Abnormal growth in either the stomach or intestine"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2849] "Cancer in the human female's reproductive organs"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2850] "Abnormal growth of the tissues of the male reproductive tract: penis, scrotum and contents including testicles, prostate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2851] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2852] "A rare disorder in which noncancerous growths develop in lymph node tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2853] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2854] "(glee-o-blas-TOE-ma mul-tih-FOR-may) A type of brain tumor that forms from glial (supportive) tissue of the brain. It grows very quickly and has cells that look very different from normal cells. Also called grade IV astrocytoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2855] "(glee-O-ma) A cancer of the brain that begins in glial cells (cells that surround and support nerve cells)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2856] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2857] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2858] "(GLOO-kuh-guh-NO-ma) A rare pancreatic tumor that produces a hormone called glucagon. Glucagonomas can produce symptoms similar to diabetes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2859] "An incompatibility reaction (which may be fatal) in a subject (host) of low immunological competence (deficient lymphoid tissue) who has been the recipient of immunologically competent lymphoid tissue from a donor who lacks at least one antigen possessed by the recipient host; the reaction, or disease, is the result of action of the transplanted cells against those host tissues that possess the antigen not possessed by the donor. Seen most commonly following bone marrow transplantation, acute disease is seen after 5-40 days and chronic disease weeks to months after transplantation, affecting, principally, the gastrointestinal tract, liver, and skin."                                                                                                                                                                                                                                                                                                                  
 [2860] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2861] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2862] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2863] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2864] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2865] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2866] "A type of slow-growing, malignant tumor that usually affects the ovary."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2867] "Hyperthyroidism associated with diffuse hyperplasia of the thyroid gland (goiter), resulting from production of antibodies that are directed against the thyrotropin receptor complex of the follicular epithetlial cells.  As a result, the thyroid gland enlarges and secrets increased amounts of thyroid hormones. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2868] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2869] "Gynecomastia; excessive development of the breasts in males; usually the result of hormonal imbalance or treatment with certain drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2870] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2871] "(ham-ar-TOE-ma) A benign (noncancerous) growth made up of an abnormal mixture of cells and tissues normally found in the area of the body where the growth occurs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2872] "An autosomal dominant hereditary syndrome characterized by a variety of hamartomas and neoplasms including verrucous skin lesions, fibromas of the oral cavity, facial trichilemmomas, hamartomatous colonic polyps, thyroid neoplasms, breast cancer, and dysplastic gangliocytomas of the cerebellum. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2873] "For oncology, area of the body generally construed to comprise base of skull and facial bones, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature and lymph nodes draining these areas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2874] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2875] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2876] "1. inadequacy of the heart so that as a pump it fails to maintain the circulation of blood, with the result that congestion and edema develop in the tissues; SEE ALSO forward heart failure, backward heart failure, right ventricular failure, left ventricular failure. SYN cardiac failure, cardiac insufficiency, congestive heart failure, myocardial insufficiency. 2. resulting clinical syndromes including shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales in various combinations."                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2877] "Abnormal growth of the cells comprising the cardiac muscle, valves, and/or vessels"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2878] "One of a group of rare disorders of immunoglobulin synthesis associated with B-cell proliferative disorders and diagnosed by the finding of heavy chains in the serum, urine, or both. Heavy chains are immunologically related to the Fc fragment of the immunoglobulin chain. Three types of heavy chain disease (HCD) have been recognized: gamma heavy chain disease (associated with Waldenstrom's macroglobulinemia), alpha heavy chain disease (also known as immunoproliferative small intestinal disease or Mediterranean lymphoma), and mu heavy chain disease (associated with chronic lymphocytic leukemia). Complications of HCD vary depending upon type. Also known as paraproteinemia. --2004"                                                                                                                                                                                                                                                                                      
 [2879] "A clonal disorder characterized by the secretion of a truncated gamma chain.  In most cases, it is associated with morphologic changes also seen in lymphoplasmacytic lymphomas, but the clinical course is typically more aggressive than in lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2880] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2881] "benign tumor made up of newly formed blood vessels."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2882] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2883] "A mesenchymal tumor of perivascular cell origin, composed of dilated vascular spaces (some with a staghorn or bifed shape) throughout the entire tumor.  The tumor cells are surrounded by reticulin, are negative for muscle, nerve sheath, and epithelial markers, and are positive for CD34.  The biologic behavior of hemangiopericytoma cannot always be predicted from the morphologic features.  The 5- and 10-year survival rates of malignant hemangiopericytomas have been reported to be 40% and 29% respectively (partially adapted from S. Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999). -- 2004"                                                                                                                                                                                                                                                                                                                                                                         
 [2884] "(AN-jee-o-sar-KO-ma) A type of cancer that begins in the lining of blood vessels."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2885] "A condition in which free hemoglobin is found in the urine. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2886] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2887] "A deficiency or abnormality of a blood coagulation factor characterized by the tendency to spontaneous or exaggerated post-traumatic hemorrhage, Hemophilia is typically a hereditary disorder but, rarely, may be acquired. Inherited coagulation factor-deficient hemophilias include hemophilia A or classic hemophilia (Factor VIII deficiency) hemophilia B or Christmas disease (Factor IX deficiency), and hemophilia C (Factor XI deficiency). In individuals without hereditary hemophilia A, Factor VIII inhibitors may occur spontaneously as autoantibodies, resulting in a condition known as 'acquired hemophilia.' Approximately 10 % of patients with acquired hemophilia have an underlying malignancy. --2004"                                                                                                                                                                                                                                                                    
 [2888] "Hemoptysis; coughing up blood from the respiratory tract."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2889] "(hep-a-TYE-tis) Disease of the liver causing inflammation.  Symptoms include an enlarged liver, fever, nausea, vomiting, abdominal pain, and dark urine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2891] "RAEB: Used for the diseases or the viruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2892] "A virus that causes hepatitis (inflammation of the liver).  It is carried and passed to others through blood or sexual contact. Also, infants born to infected mothers may become infected with the virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2893] "(HEP-a-toe-SEL-yoo-ler kar-sin-O-ma) A type of adenocarcinoma, the most common type of liver tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2894] "Hepatomegaly; abnormal enlargement of the liver."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2895] "Genetic Diseases are diseases in which inherited genes predispose to increased risk.  The genetic disorders associated with cancer often result from an alteration or mutation in a single gene.  The diseases range from rare dominant cancer family syndrome to familial tendencies in which low-penetrance genes may interact with other genes or environmental factors to induce cancer.  Research may involve clinical, epidemiologic, and laboratory studies of persons, families, and populations at high risk of these disorders."                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2896] "A rare inherited disorder in which blood vessels grow abnormally in the eyes, brain, spinal cord, adrenal glands, or other parts of the body. People with von Hippel-Lindau syndrome have a higher risk of developing some types of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2897] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2898] "A neoplastic proliferation of Langerhans cells which contain Birbeck granules by ultrastructural examination.  Three major overlapping syndromes are recognized: eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease.  The clinical course is generally related to the number of organs affected at presentation.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2899] "any state accompanied by evidence of HIV in the body (positive test for HIV genome, cDNA, proteins, antigens, or antibodies); may be medically asymptomatic or symptomatic; prefer AIDS when appropriate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2900] "A sudden, temporary onset of body warmth, flushing, and sweating (often associated with menopause)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2901] "A gestational disorder characterized by an abnormal placenta with marked enlargement of the chorionic villi and hyperplasia of the villous trophoblastic cells.  According to the amount of villous involvement, a hydatidiform mole is defined as complete or partial.  Most molar pregnancies are complete and are characterized by generalized hydropic villous changes.  Partial moles are characterized by a mixture of large hydropic villi and normal placenta tissue.  Complete moles are usually diploid and typically present between the eleventh and twenty-fifth week of pregnancy, whereas partial moles are usually triploid and usually present around the nineteenth week of pregnancy.  The incidence of choriocarcinoma is higher in patients with complete hydatidiform mole.  When a hydatidiform mole invades the myometrium and broad ligament, or it is found in distant sites as vagina, vulva, and lung, it is referred as invasive mole. --2004"                         
 [2902] "(hye-dro-SEF-uh-lus) The abnormal buildup of cerebrospinal fluid in the ventricles of the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2903] "(hye-per-kal-SEE-mee-a) Abnormally high blood calcium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2904] "(hye-per-PLAY-zha) An abnormal increase in the number of cells in an organ or tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [2905] "An exaggerated response by the immune system to a drug or other substance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2906] "DTH. An inflammatory response that develops 24 to 72 hours after exposure to an antigen that the immune system recognizes as foreign.  This type of immune response involves mainly T cells rather than antibodies (which are made by B cells)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2907] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2908] "Abnormally high blood pressure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2910] "abnormally increased pressure in the portal venous system, frequently seen in cirrhosis of the liver and other conditions causing obstruction of the portal vein."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2911] "increased pressure with the the pulmonary circulation, usually secondary to cardiac or pulmonary disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2912] "hypertension due to renal disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2913] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2914] "Too much thyroid hormone. Symptoms include weight loss, chest pain, cramps, diarrhea, and nervousness.  Also called hyperthyroidsm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2915] "Hypertrophy; the abnormal enlargement of a body part or organ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2916] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2917] "Abnormally low blood sugar."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [2918] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2919] "Abnormally low blood pressure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2920] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2922] "Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2923] "A clonal disorder, also known as immunoproliferative small intestinal disease or Mediterranean lymphoma, characterised by the secretion of a defective alpha heavy chain.  It predominantly affects young people in the Mediterranean region.  It involves the small intestine, and patients usually present with malabsorption syndrome, abdominal pain, weight loss, and fever.  There is extensive villous atrophy of the small intestinal mucosa, which is heavily infiltrated by small lymphocytes and plasma cells.  The small intestinal morphologic changes are consistent with a mucosa-associated lymphoid tissue lymphoma (MALT lymphoma).  Alpha heavy chain disease frequently progresses to large B-cell lymphoma, and normally has a poor prognosis. -- 2004"                                                                                                                                                                                                                        
 [2924] "(IM-po-tent) Unable to have an erection adequate for sexual intercourse."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2926] "A localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation. --2004"                                                                                                                                                                                                                                                                                                                                                                                             
 [2927] "A general term that refers to the inflammation of the colon and rectum. Inflammatory bowel disease includes ulcerative colitis and Crohn's disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2928] "Benign and malignant neoplasms which occur in brain parenchymal tissue below the tentorium cerebelli.  This primarily refers to neoplasms within the brainstem and/or cerebellum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2929] "This is a rare insulin secreting neuroendocrine tumor.  The majority of insulinomas are small, non-metastatic and occur as solitary tumors.  They are most often confined to the pancreas.  Diagnostic examinations include: patient history for related hypoglycemic symptoms and fasting tests with repeated glucose and insulin levels.  The treatment of choice is tumor resection. - 2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2930] "Abnormal growth of the cells of the intestinal tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2932] "(JAWN-dis) A condition in which the skin and the whites of the eyes become yellow, urine darkens, and the color of stool becomes lighter than normal. Jaundice occurs when the liver is not working properly or when a bile duct is blocked."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2933] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2934] "(KEY-loyd) A thick, irregular scar caused by excessive tissue growth at the site of an incision or wound."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2935] "(KER-a-toe-AK-an-THOW-ma) A benign (noncancerous), rapidly growing skin tumor that usually occurs on sun-exposed areas of the skin and that can go away without treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2936] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2937] "(ak-TIN-ik ker-a-TOE-sis) A precancerous condition of thick, scaly patches of skin. Also called solar or senile keratosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2938] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2939] "Abnormal growth of tissues of the kidney"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2940] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2941] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2942] "(KROO-ken-berg TOO-mer) A tumor in the ovary caused by the spread of stomach cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2943] "The inability to digest or absorb lactose, a type of sugar found in milk and other dairy products."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2944] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2945] "(lair-IN-jee-al) Having to do with the larynx."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [2946] "(FYE-broyd) A benign smooth-muscle tumor, usually in the uterus or gastrointestinal tract. Also called leiomyoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2947] "A common malignant mesenchymal neoplasm.  It originates from the smooth muscles, and the most common anatomic sites are the uterus and the gastrointestinal tract.  It is characterized by spindle cell morphology.  Cellular pleomorphism may be present. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2948] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2949] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2950] "(loo-KEE-mee-a) Cancer of blood-forming tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2951] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2952] "A slowly progressing disease in which too many white blood cells (called lymphocytes) are found in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2953] "An acute myeloid leukemia in which the immature cells differentiate towards basophils.  This is a rare leukemia.  The observed cases have been associated with a poor prognosis.  The term basophilic leukemia is used as a synonym for acute basophilic leukemia.  Chronic basophilic leukemia is an inappropriate term vaguely connected to the term mast cell leukemia.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2954] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2955] "A leukemia with an acute onset, characterized by the presence of lymphoblasts or Burkitt cells in the bone marrow and the peripheral blood.  It includes the precursor B lymphoblastic leukemia, precursor T lymphoblastic leukemia, and Burkitt's leukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2956] "A heterogeneous disorder characterized by an uncontrolled proliferation and conspicuous enlargement of lymphoid tissue and the occurrence of increased numbers of cells in the lymphatic system circulating in the blood, occurring in children. (from DCTD)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2957] "A variant of systemic mastocytosis with involvement of the bone marrow (20% or more mast cells) and the peripheral blood (mast cells account for 10% or more of peripheral blood white cells). (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2958] "An acute myeloid leukemia in which at least 50% of the blasts are of megakaryocytic lineage.  The prognosis is usually poor.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2959] "A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues.  The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities 2) AML with multilineage dysplasia 3) Therapy-related AML 4) AML not otherwise categorized.  The required bone marrow or peripheral blood blast percentage for the diagnosis of AML has been recently reduced from 30% (French-American-British [FAB] classification) to 20% (WHO classification).  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2960] "leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors in the bone marrow and other sites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2961] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2962] "A slowly progressing disease in which too many white blood cells are made in the bone marrow. Also called chronic myelogenous leukemia or chronic myeloid leukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2963] "A phase of chronic myelogenous leukemia that may last from several months to several years. Although there may be no symptoms of leukemia, there are too many white blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2965] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2966] "A myelodysplastic/myeloproliferative disease which is characterized by persistent monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer than 20% blasts in the bone marrow or blood, and myelodysplasia.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2967] "A rare chronic myeloproliferative disorder characterised by neutrophilic leukocytosis.  There is no detectable Philadelphia chromosome or BCR/ABL fusion gene.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2968] "rare type of acute leukemia in which the predominating cell in the peripheral blood is the plasma cell; it is often seen in conjunction with multiple myeloma and may be a variant form of that disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2969] "PLL. A type of chronic lymphocyctic leukemia (CLL), in which too many immature white blood cells (prolymphocytes) are found in the blood and bone marrow. PLL usually progresses more rapidly than classic CLL."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [2970] "A type of acute myeloid leukemia, a quickly progressing disease in which too many immature blood-forming cells are found in the blood and bone marrow."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [2971] "This type of acute lymphoblastic leukemia comprises about 15% of childhood cases and 25% of adult cases.  It is more common in males than females.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [2972] "A peripheral (mature) T-cell neoplasm caused by the human T-cell leukemia virus type 1 (HTLV-1).  Adult T-cell lymphoma/leukemia is endemic in several regions of the world, in particular Japan, the Caribbean, and parts of Central Africa. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2973] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2974] "(loo-ko-PLAY-kee-a) A white patch that may develop on mucous membranes such as the cheek, gums, or tongue and may become cancerous."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2975] "A white patch or plaque on oral mucosa that cannot be characterized clinically or pathologically as any other disease. The diagnosis of leukoplakia is one of exclusion; other conditions such as candidiasis, lichen planus, leukoedema, etc. must be ruled out before a diagnosis of leukoplakia can be made. Leukoplakia may be a premalignant condition. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [2976] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2977] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2979] "Abnormal growth of the cells that comprise the lips of the mouth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [2980] "A benign, encapsulated lipomatous tumor composed of mature adipose (fatty) tissue. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [2981] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2982] "A malignant tumor that arises from adipose tissue (fat).  Microscopically, it may contain a spectrum of neoplastic adipocytes (fat cells) ranging from lipoblasts to pleomorphic malignant adipocytes.  According to the degree of differentiation, liposarcomas may be classified as well differentiated, dedifferentiated, pleomorphic, myxoid, and round cell liposarcomas.  The metastatic potential is higher in less differentiated tumors. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2983] "Any disease or dysfunction of the liver."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [2984] "A mass in the mammary gland, either mobile or immobile. Once the mass has reached the size of a small garden pea, it can be detected by palpation. With mammography a larger number of early breast cancers are being detected since this techniques allows detection prior to the point at which the mass can be felt. Breast masses are not always malignant. Benign fibrocystic breast disease is not uncommon. A fine needle biopsy aspiration can distinguish a cystic mass from a solid one."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [2985] "Diseases of the lung"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [2986] "chronic, irreversible obstruction of air flow from the lungs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [2987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2988] "RAEB: Systemic lupus erythematosus (SLE). an autoimmune connective tissue disease with variable features."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [2989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2991] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2993] "(ad-en-OP-a-thee) Large or swollen lymph glands."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2994] "(LIMF-eh-DEE-ma) A condition in which excess fluid collects in tissue and causes swelling. It may occur in the arm or leg after lymph vessels or lymph nodes in the underarm or groin are removed or treated with radiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [2995] "(lim-FO-ma) Cancer that arises in cells of the lymphatic system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2996] "A neoplasm of follicle centre B cells which has at least a partial follicular pattern.  Follicular lymphomas comprise about 35% of adult non-Hodgkin's lymphomas in the U.S. and 22% worldwide.  Most patients have widespread disease at diagnosis.  Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present.  The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)].  Histological grade correlates with prognosis.  Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001). -- 2003"                                                                                                                                                                                                                                                                                                                                      
 [2997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2998] "A group of cancers of the lymphoid system, including acute lymphoblastic leukemia, B-cell lymphoma, Burkitt's lymphoma, diffuse cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, lymphoblastic lymphoma, mantle cell lymphoma, mycosis fungoides, post-transplantation lymphoproliferative disorder, small non-cleaved cell lymphoma, and T-cell lymphoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [2999] "(MAK-ro-GLOB-u-li-NE-me-uh) A condition in which the blood contains high levels of large proteins and is too thick to flow through small blood vessels. One type is Waldenstrom's macroglobulinemia, which is a type of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3001] "A group of symptoms such as gas, bloating, abdominal pain, and diarrhea resulting from the body's inability to properly absorb nutrients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3002] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3003] "Abnormal growth of cells comprising the retina with malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3004] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3005] "A variant of cutaneous mastocytosis which is seen almost exclusively in children. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3007] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3008] "Abnormal growth of the cells of the tissues contained within the mediastinum e.g. thymus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3009] "(MED-yoo-lo-blas-TOE-ma) A malignant brain tumor that begins in the lower part of the brain and that can spread to the spine or to other parts of the body. Medulloblastomas are a type of primitive neuroectodermal tumor (PNET)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3010] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3011] "A form of skin cancer that arises in melanocytes, the cells that produce pigment. Melanoma usually begins in a mole."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3012] "The MEN1 gene is a cloned tumor suppressor gene for Multiple Endocrine Neoplasia, a predisposition for endocrine tumors and carcinoid tumors.  The gene encodes the tumor suppressor protein MEN1, which regulates transcription through direct interaction with, and inhibition of, transcription factor JunD.  Menin also interacts with SMAD3 and appears to be required for SMAD3/4-DNA binding at transcriptional regulatory sites.  The human gene is located at 11q13."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3013] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3014] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3015] "Onset of menses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3016] "A variety of neoplastic lesions develop in the meninges, but tumors originating from meningothelial cells are most prevalent. Meningeal Tumors include: Meningiomas; Mesenchymal, Non-Meningothelial Tumors; Hemangiopericytomas; and Melanocytic Tumors. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3017] "(meh-nin-jee-O-ma) A type of tumor that occurs in the meninges, the membranes that cover and protect the brain and spinal cord. Meningiomas usually grow slowly."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3018] "(MEN-o-pawz) The time of life when a woman's menstrual periods stop permanently. Also called \"change of life.\""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3019] "Periodic discharge of blood and tissue from the uterus.  Until menopause, menstruation occurs approximately every 28 days when a woman is not pregnant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3020] "An obsolete term describing a soft tissue tumor which consists of two or more mesenchymal lines of differentiation, excluding a fibroblastic line of differentiation. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3021] "A benign (noncancerous) or malignant (cancerous) tumor affecting the lining of the chest or abdomen.  Exposure to asbestos particles in the air increases the risk of developing malignant mesothelioma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3022] "A condition in which normal metabolic processes are disrupted, usually because of a missing enzyme."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3023] "A change of cells to a form that does not normally occur in the tissue in which it is found."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3024] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3025] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3026] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3027] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3028] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3029] "(mye-eh-LO-ma) Cancer that arises in plasma cells (white blood cells that produce antibodies)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3030] "A disorder of the central nervous system marked by weakness, numbness, a loss of muscle coordination, and problems with vision, speech, and bladder control. Multiple sclerosis is thought to be an autoimmune disease in which the body's immune system destroys myelin. Myelin is a substance that contains both protein and fat (lipid), serving as a nerve insulator and helping in the transmission of nerve signals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3031] "Discomfort referable to either the muscles or the bones themselves."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3032] "An infection caused by eukaryotic heterotrophic organisms that live as saprobes or parasites, including mushrooms, yeasts, smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi refer to those that grow as multicellular colonies (mushrooms and molds)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3033] "(mye-KO-sis fun-GOY-deez) A type of non-Hodgkin's lymphoma that first appears on the skin and can spread to the lymph nodes or other organs such as the spleen, liver, or lungs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3034] "(MYE-eh-lo-dis-PLAS-tik SIN-drome) Disease in which the bone marrow does not function normally. Also called preleukemia or smoldering leukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3035] "A disorder in which the bone marrow is replaced by fibrous tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3036] "An acute myeloid leukemia (AML) characterized by blasts without evidence of maturation to more mature neutrophils.  The patients present with anemia, neutropenia, and thrombocytopenia.  This type of AML usually follows an aggressive clinical course.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3037] "An acute myeloid leukemia (AML) characterized by blasts with evidence of maturation to more mature neutrophils.  The patients often present with anemia, neutropenia, and thrombocytopenia.  AML with the t(8;21) is usually AML with maturation.  This type of AML responds frequently to aggressive therapy.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3038] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3039] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3040] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3041] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3042] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3043] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3044] "Nausea is the sensation of unease and discomfort from the stomach, with the sufferer feeling that he is about to vomit. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3045] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3046] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3047] "A tumor that has spread from its original (primary) site of growth to another site, close to or distant from the primary site.  Metastasis is characteristic of advanced malignancies, but in rare instances can be seen in neoplasms lacking malignant morphology. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3048] "(NEE-o-PLAY-zha) Abnormal and uncontrolled cell growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3049] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3050] "A usually malignant neoplasm of childhood composed of primitive (immature) tissues that resemble fetal tissues.  Medulloblastoma, Ependymoblastoma, Pineoblastoma, and Wilms tumor are representative embryonal neoplasms. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3051] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3052] "The inherited predisposition toward getting a cancer"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3053] "A kidney cancer that usually occurs in children younger than 5 years old."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3054] "Abnormal growth of the cells that comprise the tissues of the central or peripheral nervous system, without specification as to whether the growth is benign or malignant in nature."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3055] "(shwah-NO-ma)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3056] "Cancer that arises in immature nerve cells and affects mostly infants and children."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3057] "A benign tumor that develops from the cells and tissues that cover nerves."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3058] "NF1. A rare genetic condition that causes brown spots and tumors on the skin, freckling in skin areas not exposed to the sun, tumors on the nerves, and developmental changes in the nervous system, muscles, bone, and skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3059] "A genetic condition in which tumors form on the nerves of the inner ear and cause loss of hearing and balance.  Tumors may also occur in the brain and on nerves in the skull and spinal cord, and may cause loss of speech, eye movement, and the ability to swallow.  Also called neurofibromatosis type 2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3060] "(noo-RO-ma) A tumor that arises in nerve cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3061] "A type of benign brain tumor that begins in the Schwann cells, which produce the myelin that protects the acoustic nerve - the nerve of hearing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3062] "A decrease in the number of mature granulocytes (neutrophils, eosinophils, and basophils) in the peripheral blood. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3063] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3064] "(NOD-yool) A growth or lump that may be cancerous or noncancerous."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3065] "Involuntary movements of the eyeballs.  The presence or absence of nystagmus is often used in the diagnosis of a variety of neurological and visual disorders."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3066] "Is a Body Mass Index (BMI of 30 or above).  BMI describes body weight relative to height and is strongly correlated to total body fat content in adults.  The rIsk of death increases as the BMI reaches and surpasses 30. (CDC98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3067] "Blockage of a passageway."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3068] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3069] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3070] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3071] "(OL-ih-go-den-dro-glee-O-ma) A rare, slow-growing tumor that begins in the oligodendrocytes (brain cells that provide support and nourishment for nerve cells).  Also called an oligodendroglial tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3072] "An infection caused by an organism that does not normally cause disease. Opportunistic infections occur in people with weakened immune systems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3073] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3074] "Abnormal growth of the cells that comprise the oropharynx."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3075] "Paget's Disease is a disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3076] "Noninflammatory degenerative joint disease occurring chiefly in older persons, characterised by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3077] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3078] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3079] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3080] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3081] "(OSS-tee-oh-pa-ROW-sis) A condition that is characterized by a decrease in bone mass and density, causing bones to become fragile."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3082] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3083] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3084] "A form of breast cancer in which the tumor grows from ducts beneath the nipple onto the surface of the nipple. Symptoms commonly include itching and burning and an eczema-like condition around the nipple, sometimes accompanied by oozing or bleeding."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3085] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3086] "A feeling of distress, suffering, or agony caused by stimulation of specialized nerve endings. (OSM94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3087] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3088] "Abnormal growth of the cells (either cancerous or non-cancerous) of the pancreas, the gland that secrets insulin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3089] "Inflammation of the pancreas. Chronic pancreatitis may cause diabetes and problems with digestion. Pain is the primary symptom."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3090] "(pap-il-eh-DEE-ma) Swelling around the optic disk, the area where the optic nerve (the nerve that carries messages from the eye to the brain) enters the eyeball. Papilledema occurs when increased brain pressure caused by tumors or other problems results in swelling of the optic nerve."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3091] "Abnormal growth of the paraganglion cells without specifying whether the growth is benign or malignant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3092] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3093] "(pa-RAL-ih-sis) Loss of ability to move all or part of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3094] "(pair-a-nee-o-PLAS-tik) A group of symptoms that may develop when substances released by some cancer cells disrupt the normal function of surrounding cells and tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3095] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3096] "Abnormal growth of the cells that comprise the parathyroid gland without specification as to whether the growth is benign or malignant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3097] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3098] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3099] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3100] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3101] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3102] "An abnormal collection of fluid inside the sac that covers the heart."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3103] "A benign or malignant neoplasm arising from a peripheral nerve or the perineural sheaths. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3104] "Abnormal growth of cells in the peritoneum"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3105] "(peh-TEH-kee-a) Pinpoint, unraised, round red spots under the skin caused by bleeding."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3106] "An inherited condition characterized by generalized hamartomatous multiple polyposis of the intestinal tract. Transmitted in an autosomal dominant fashion, Peutz-Jeghers syndrome consistently involves the jejunum and is associated with melanin spots of the lips, buccal mucosa, and fingers. This syndrome is associated with abnormalities of chromosome 19. Also known as Jeghers-Peutz syndrome and Peutz's syndrome. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3107] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3108] "An uncommon neuroendocrine tumor secreting catecholamines and located in the medullary portion of the adrenal gland (approximately 70% of cases) or in the extra adrenal paraganglia.  Approximately 90% of cases are sporadic and 10% are familiar.  Common symptoms include headache, chest pain, palpitations, anxiety, and weight loss.  Microscopically, pheochromocytomas are composed of polygonal cells usually arranged in alveolar, trabecular, or solid patterns.  Malignant pheochromocytomas are slow growing tumors and represent a minority of cases.  The most common sites of metastases are lymph nodes, bones, and liver. -- 2004"                                                                                                                                                                                                                                                                                                                                               
 [3109] "A change from the patient's baseline skin coloration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3110] "(pIN-ee-al...) A type of brain tumor that occurs in or around the pineal gland, a tiny organ near the center of the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3111] "Abnormal growth of cells in the pituitary gland that can either secrete hormone or not.  The diagnosis can be based on imaging studies and/or radioimmunoassays.  Due to their location in the sella turcica, expansion of the tumor mass can impinge on the optic chiasm or involve the temporal lobe, third ventricle and posterior fossa.  A frequently associated physical finding is bitemporal hemianopsia which may progress to further visual loss."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3112] "Abnormal growth of the cells that comprise the pituitary gland without specification as to whether the cells are malignant or benign."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3113] "An abnormal collection of fluid between the thin layers of tissue (pleura) lining the lung and the wall of the chest cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3114] "A benign or malignant neoplasm that involves the serous membrane that lines the lungs and thoracic cavity. Most pleural neoplasms are metastatic. Diffuse malignant mesothelioma is the most common primary malignant neoplasm of the pleura. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3115] "(noo-MONE-ya) An inflammatory infection that occurs in the lung."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3116] "Pneumocystis carinii pneumonia (PCP). pneumonia resulting from infection with Pneumocystis carinii, frequently seen in the immunologically compromised, such as persons with AIDS, or steroid-treated individuals, the elderly, or premature or debilitated babies during their first three months.  Patients may be only slightly febrile (or even afebrile), but are likely to be extremely weak, dyspneic, and cyanotic. This is a major cause of morbidity among patients with AIDS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3117] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3118] "A chronic myeloproliferative disorder characterized by an increased red blood cell production.  Excessive proliferation of the myeloid lineage is observed as well.  The major symptoms are related to hypertension or to vascular abnormalities caused by the increased red cell mass.  The cause is unknown.  With currently available treatment, the median survival exceeds 10 years.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3119] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3120] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3121] "(pah-li-PO-sis) An inherited condition in which numerous polyps (growths that protrude from mucous membranes) form on the inside walls of the colon and rectum. It increases the risk for colon cancer. Also called familial adenomatous polyposis or FAP."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3122] "(POL-ip) A growth that protrudes from a mucous membrane."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3123] "(pre-KAN-ser-us) A term used to describe a condition that may (or is likely to) become cancer. Also called premalignant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3124] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3125] "A benign or malignant tumor involving the prostate gland. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3126] "Pruritus; an intense itching sensation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3127] "(SOO-doe-mix-O-ma PAIR-ih-TOE-nee-I) A build-up of mucus in the peritoneal cavity. The mucus may come from ruptured ovarian cysts, the appendix, or from other abdominal tissues, and mucus-secreting cells may attach to the peritoneal lining and continue to secrete mucus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3128] "A chronic disease of the skin marked by red patches covered with white scales."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3129] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3130] "A subcategory of chronic obstructive pulmonary disease (COPD).  It occurs in people who smoke and suffer from chronic bronchitis.  It is characterized by inflation of the alveoli, alveolar wall damage, and reduction in the number of alveoli, resulting in difficulty breathing.  Alveoli are the vital lung structures where the transfer of oxygen and carbon dioxide takes place. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3131] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3132] "Either benign or malignant growth of tissue in rectum, the terminal protion of the digestive tube."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3133] "This is a descriptive term referring of a mass of tissue that bulges or projects into the lumen of the rectum.  The mass is macroscopically visible and may either have a broad base attachment to the rectal wall, or be on a pedunculated stalk.  These may be benign or malignant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3134] "To occur again."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3135] "fulminant pulmonary interstitial and alveolar edema resulting from diffuse infection, shock, or trauma of the lungs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3136] "infection with respiratory syncytial virus, an RNA virus of the genus Pneumovirus, in the family Paramyxoviridae, with a tendency to form syncytia in tissue culture, that causes minor respiratory infection with rhinitis and cough in adults, but is capable of causing severe bronchitis and bronchopneumonia in young children; first isolated from chimpanzees with respiratory disease. SYN chimpanzee coryza agent, Rs virus.  It is a disease associated with HIV infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3137] "Abnormal growth in the respiratory tract"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3138] "A rare cutaneous tumor composed of eosinophilic histiocytes, which are often multinucleated.  The lesions are yellow-brown papules affecting any part of the body.  Patients are usually adult men.  The prognosis is excellent. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3139] "Benign and malignant neoplasms which arise from, or occur in, the walls and/or cavities of the abdomen, pelvis, and retroperitoneal space."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3140] "A benign lesion of the striated muscle.  It can occur in the head and neck and the vagina.  Simple excision is curative. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3141] "A malignant tumor of muscle tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3142] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3143] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3144] "class of psychoses with disturbance mainly of cognition (content and form of thought, perception, sense of self versus external world, volition) and psychomotor function, rather than affect."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3145] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3146] "(SEP-sis) The presence of bacteria or their toxins in the blood or tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3147] "A disorder acquired through sexual contact. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3148] "A form of cutaneous T-cell lymphoma, a cancerous disease that affects the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3149] "Finding; the result of an examination or inquiry."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3150] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3151] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3152] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3153] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3154] "A benign or malignant tumor involving the skin -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3155] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3156] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3157] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3158] "A change from the patient's baseline sleeping pattern, either an increase or a decrease in the number of hours slept. This can also refer to alterations in the stages of sleep."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3159] "A benign or malignant tumor that arises from mesenchymal cells in extra skeletal sites.  The most common types are lipomatous (fatty), vascular, smooth muscle, fibrous, and fibrohistiocytic neoplasms. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3160] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3161] "A rare somatostatin-secreting tumor of pancreatic delta cells associated with diabetes mellitus or abnormal glucose tolerance. Usually malignant, this neoplasm secretes large amounts of somatostatin, which may result in a syndrome characterized by diarrhea, steatorrhea, weight loss, and gastric hyposecretion. Sixty percent are found in the pancreas and 40% in the duodenum or jejunum. The peak incidence occurs between 40 and 60 years of age; women are affected more than men by 2:1. Also known as somatostatinoma. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3162] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3163] "Neoplasms that occur within the parenchyma of the spinal cord (i.e. intramedullary tumors)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3164] "Neoplasms that occur within the spinal canal including the spinal cord and surrounding paraspinal spaces.  Neoplasms that occur within the substance of the spinal cord are referred to as intramedullary neoplasms.  Neoplasms that occur in the space between the spinal cord and the dura mater are referred to as extramedullary intradural neoplasms.  Tumors that occur in the spinal canal outside the dura mater are referred to as extradural neoplasms.  This category includes primary and secondary (i.e., metastatic) neoplasms.  (KEV 8-16-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3165] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3166] "Splenomegaly; an abnormal enlargement of the spleen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3167] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3168] "Cancerous or non-cancerous tumors of the stomach"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3169] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3170] "acute, chronic, or delayed reactions to traumatic events such as military combat, assault, or natural disaster."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3171] "A sudden, nonconvulsive loss of neurologic function due to an ischemic or hemorrhagic intracranial vascular event. In general, cerebrovascular accidents are classified by anatomic location in the brain, vascular distribution, etiology, age of the affected individual, and hemorrhagic vs. nonhemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3172] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3173] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3174] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3175] "Suicide is the act of ending one's own life. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3176] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3177] "A condition in which a tumor presses against the superior vena cava (the large vein that carries blood from the head, neck, arms, and chest to the heart). This pressure blocks blood flow to the heart and may cause coughing, difficulty in breathing, and swelling of the face, neck, and upper arms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3178] "Benign and malignant neoplasms which arise or occur in within the intracranial cavity above the tentorium cerebelli.  This includes neoplasms within the supratentorial brain and surrounding spaces."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3179] "Benign or malignant neoplasm involving the sweat gland. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3180] "Enlargement; expansion in size; sign of inflammation"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3181] "A malignant tumor that develops in the synovial membrane of the joints."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3182] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3183] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3184] "(ter-a-TOW-ma) A type of germ cell tumor that may contain several different types of tissue, such as hair, muscle, and bone.  Teratomas occur most often in the ovaries in women, the testicles in men, and the tailbone in children.  Not all teratomas are malignant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3185] "Benign or malignant neoplasm involving the testis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3186] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3187] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3188] "A chronic myeloproliferative disorder that involves primarily the megakaryocytic lineage and it is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and episodes of thrombosis and/or hemorrhage.  The cause is unknown.  Median survival times of 10-15 years are commonly reported.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3189] "A condition in which there is an abnormally small number of platelets in the circulating blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3190] "(throm-bo-fleh-BY-tis) Inflammation of a vein that occurs when a blood clot forms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3191] "A neoplasm arising from the epithelial cells of the thymus.  Although thymomas are usually encapsulated tumors, they may invade the capsule and infiltrate the surrounding tissues or even metastasize to distant anatomic sites.  The following morphologic subtypes are currently recognized: type A, type B, type AB, and type C.  Thymomas type B are further subdivided into types B1, B2, and B3.  Thymoma types B3 and C usually have the most aggressive clinical course.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3192] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3193] "Abnormal growth of the cells that comprise the thyroid gland without indication of whether the growth is benign or malignant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3194] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3195] "Abnormal growth of the cells that comprise the tongue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3196] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3197] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3198] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3199] "A type of aberration characterized by fragmentation of a chromosome and transfer of the broken-off portion to another chromosome, often of a different pair. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3200] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3201] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3202] "A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use. --2004"                                        
 [3203] "RAEB: Hereditary disease characterized by seizures, mental retardation, developmental delay, and skin and ocular lesions. First signs usually occur during infancy or childhood but in rare cases may not occur until 2nd or 3rd decade. Code also in SIC180 (rare diseases)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3204] "A condition of metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells. Tumor lysis syndrome typically occurs in aggressive, rapidly proliferating lymphoproliferative disorders. Burkitt lymphoma and T cell acute lymphoblastic leukemia are commonly associated with this syndrome. Metabolic abnormalities include hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia and may result in renal failure, multiple organ failure, and death. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3205] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3206] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3207] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3208] "(in-KAHN-tih-nens) Inability to control the flow of urine from the bladder (urinary incontinence) or the escape of stool from the rectum (fecal incontinence)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3209] "Disorders of any part of the urologic system"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3210] "Benign or malignant neoplasm involving the urinary tract. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3211] "Urticaria; an itchy skin eruption characterized by weals with pale interiors and well-defined red margins; usually the result of an allergic response to insect bites or food or drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3212] "The most frequent form of cutaneous mastocytosis.  In children, the lesions tend to be papular, and are characterized by aggregates of elongated or spindle-shaped mast cells which fill the papillary dermis and extend into the reticular dermis.  In adults, the lesions tend to have fewer mast cells compared to those in children.  The lesions are located most commonly on the trunk, but they can be seen on the extremities, head and neck. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3213] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3214] "Abnormal growth in the tissues of uterus, either cancerous or non-cancerous."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3215] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3216] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3217] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3218] "Any disease caused by a virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3219] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3220] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3221] "Vomiting; the reflex act of ejecting the contents of the stomach through the mouth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3222] "A neoplasm involving the cells of the vulva, i.e. the labia majora the labia minora and the clitori. This neoplasm can be either benign or malignant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3223] "A multisystem disease chiefly affecting males, characterized by necrotizing granulomatous vasculitis involving the upper and lower respiratory tracts, glomerulonephritis, and variable degrees of systemic, small vessel vasculitis, which is generally considered to represent an aberrant hypersensitivity reaction to an unknown antigen. (Dorland, 27th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3224] "A reduction in overall body mass."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3225] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3226] "Werner Syndrome (WS) is an inherited disease characterized by an early onset of atherosclerosis, osteoporosis, diabetes mellitus, and cancers of non-epithelial cell origin. Cultured cells from WS patients also present a shortened replicative lifespan and increased genetic instability. The genomic instability of WS cells is manifested at the cytogenetic level in the form of chromosome breaks and translocations, and at the molecular level predominately by multiple, large DNA deletions. (J. Biol. Chem., 273(51):34139-34144, 1998)"                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3227] "A rare, X-linked immunodeficiency syndrome characterized by eczema, thrombocytopenia, and recurrent pyogenic infection. It is seen exclusively in young boys. Typically, IgM levels are low and IgA and IgE levels are elevated. Lymphoreticular malignancies are common."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3228] "A benign fibrohistiocytic neoplasm that occurs during childhood; it is distinct from Langerhans cell histiocytosis.  The lesions usually develop during infancy, and are characterized by regressing cutaneous nodules (most often in the head and neck) sometimes associated with deep soft tissues nodules.  The prognosis is excellent. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3229] "A genetic condition characterized by a sensitivity to all sources of ultraviolet radiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3230] "A disorder in which tumors of the pancreatic islet cells produce large amounts of gastrin (a hormone), leading to excess acid in the stomach and, possibly, a peptic ulcer (ulcer of the stomach or the upper part of the small intestine)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3231] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3232] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3233] "The most common type of non-Hodgkin's lymphoma.  It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3234] "Includes large cell, immunoblastic, lymphoblastic, and small noncleaved cell lymphomas. These lymphomas grow quickly but have a better response to anticancer drugs than that seen with low-grade lymphomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3235] "Includes diffuse, small, cleaved cell lymphoma and diffuse, large, noncleaved cell lymphoma. These are more aggressive than low-grade lymphomas, but they respond better to anticancer drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3236] "(foll-IK-yew-lar large cell lim-FO-ma) A rare type of non-Hodgkin's lymphoma (cancer of the lymphatic system) with large cells that look cleaved (split) or non-cleaved under the microscope.  It is an indolent (slow-growing) type of lymphoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3237] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3238] "Lymphomas that tend to grow and spread slowly, including chronic lymphocytic lymphoma and follicular small cleaved cell lymphoma. Also called indolent lymphomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3239] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3240] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3241] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3242] "(lim-FO-ma) A disease in which certain cells of the lymph system (called T lymphocytes) become cancerous."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3243] "A category of mature T-cell non-Hodgkin's lymphomas that involve primarily the skin.  The major representatives are mycosis fungoides and primary cutaneous anaplastic large cell lymphoma.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3244] "This type of lymphoma is not frequently seen in the western hemisphere.  Clinically, with the exception of anaplastic large cell lymphoma, mature T-and NK-cell lymphomas are among the most aggressive of all hematopoietic neoplasms.  Representative disease entities include mycosis fungoides, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, and anaplastic large cell lymphoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3245] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3246] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3247] "An aggressive lymphoma that develops in HIV-positive patients.  There is a significant increase in the incidence of lymphomas associated with the AIDS epidemic in the last two decades.  These lymphomas are usually extranodal, most often express a B-cell phenotype and morphologically are classified as Burkitt's, diffuse large B-cell, and Hodgkin's lymphomas.  The prognosis is closely related to the severity of immunodeficiency."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3248] "X-linked or autosomal recessive disorder characterized by defects of both humoral and cell mediated immunity, resulting in low or absent antibody levels, leukopenia, marked susceptibility to infections, and early death.--2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3249] "A rare type of cancer that occurs in the ventricles of the brain. It usually occurs in children younger than 2 years."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3250] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3251] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3252] "A rare, inherited predisposition to multiple cancers, caused by an alteration in the p53 tumor suppressor gene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3253] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3254] "hypertension occurring without preexisting renal disease or known organic cause."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3255] "Uncontrollable craving, seeking, and use of a substance such as a drug or alcohol."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3256] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3257] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3258] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3259] "(KRAHN-ik) A slowly progressing cancer of the blood-forming tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3261] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3262] "A rare tumor arising from smooth muscle.  The majority arise in the stomach, however the colon, bladder, vulva, and other sites may give rise to this neoplasm.  Benign and malignant variants occur."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3263] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3264] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3265] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3266] "Abnormal growth, with malignant characteristics, of the cells that comprise the lips of the mouth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3267] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3268] "abnormal and/or pathologic state usually due to mutations in structural genes for enzyme polypeptides, manifesting as metabolic abnormalities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3269] "Squamous cell carcinoma is the most frequently occuring lung carcinoma in Western countries and is the type of cancer most strongly related to cigarette smoking.  There is a marked male predominance in its incidence., with a male/female ratio of 6.6 to 15:1.  At least 50% of all squamous cell carcinomas of the lung arise in a major bronchus.  The majority of invasive squamous cell carcinomas of the lung are moderately to poorly differentiated.  In spite of an increase in knowledge concerning lung cancer, only a slight improvement has been seen in the overall postoperative 5-year survival rate during the last 30 years.  For stage I, the 5-year survival rate is approximately 60%, for stage II 48%, for stage IIIA 28%, for stage IIIB 5% and for stage IV 0% (adapted from Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999).  --2002"                                                                                                                        
 [3270] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3272] "Hypercalcemia generally develops as a late complication of malignancy; its appearance has grave prognostic significance. It remains unclear, however, whether death is associated with hypercalcemic crisis (uncontrolled or recurrent progressive hypercalcemia) or with advanced disease.  Symptoms include central nervous system impairment such as as delirium with prominent symptoms of personality change, cognitive dysfunction, disorientation, incoherent speech, and psychotic symptoms such as hallucinations and delusions, smooth muscle hypotonicity, and altered cardiovascular function."                                                                                                                                                                                                                                                                                                                                                                                         
 [3273] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3274] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3276] "Inflammation or degeneration of the peripheral motor nerves. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3277] "Inflammation or degeneration of the sensory nerves. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3278] "A benign growth within the thyroid gland. It may be associated with thyroid hormone secretion but it does not have malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3279] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3280] "Abnormal cell growth in the endometrium (the lining of the uterus)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3281] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3282] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3283] "A disorder resulting from an abnormality in the immune system. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3284] "An intense reaction (usually immunologic) developing at the site of injection"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3285] "A clinical term used to describe hyperkeratotic epithelial white patches of the genital mucous membranes.--2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3286] "A malignant neoplasm derived from cells that are capable of forming melanin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3287] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3288] "Lung adenocarcinoma is the most frequent lung cancer in Japan and some Asian countries and is said to be increasing in the United States and other economically well-developed nations.  The male/female ratio is 2:1.  Grossly, most adenocarcinomas arise in the periphery of the bronchial tree.  The 5-year postoperative survival rates for lung adenocarcinoma are as follow: Stage I: 69%, Stage II: 40%, Stage IIIA: 17%, Stage IIIB: 4% and Stage IV: 7% (Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999).  --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3289] "Esophageal carcinoma is a malignant epithelial tumor arising from the esophageal mucosa.  Two major histologic types of esophageal carcinoma have been described: squamous cell carcinoma and adenocarcinoma.  This type of cancer is associated with excessive ethanol and cigarette usage.  --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3290] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3291] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3292] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3293] "A subtype of classical Hodgkin's lymphoma with a mixed inflammatory stroma containing Hodgkin's and Reed-Sternberg cells.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3294] "A subtype of classical Hodgkin's lymphoma characterized by collagen bands surrounding lymphoid nodules. The lymphoid nodules contain lacunar and Reed-Sternberg cells.  Mediastinal involvement occurs in 80% of patients.  The prognosis of nodular sclerosis Hodgkin's lymphoma is slightly better than that of mixed cellularity or lymphocyte depleted subtype. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3295] "A myelodysplastic/myeloproliferative disease characterized by the principal involvement of the neutrophil series with leukocytosis and multilineage dysplasia.  The neoplastic cells do not have a Philadelphia chromosome or the BCR/ABL fusion gene.  The prognosis is usually poor.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3296] "A tumor mass composed of myeloblasts or immature myeloid cells.  It occurs in extramedullary sites or the bone.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3297] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3298] "Dilatation of the mammary duct without atypical cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3299] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3300] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3301] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3302] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3303] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3304] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3305] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3306] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3307] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3308] "Clinical esophageal segment composed of smooth muscle.  It includes the middle third topographic segment, as well as parts of the upper and lower thirds."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3309] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3310] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3311] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3312] "Malignant neoplasm originating in the ampulla of Vater."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3313] "A primary or metastatic malignant neoplasm involving the retroperitoneum.  The vast majority of cases are carcinomas, lymphomas, or sarcomas.--2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3314] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3315] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3316] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3317] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3318] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3319] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3320] "A malignant neoplasm arising in the glottic area of the larynx.  The vast majority of cases represent squamous cell carcinomas.--2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3321] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3322] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3323] "Malignant cancers originating in the pleura"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3324] "Malignant neoplasms originating in the heart"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3325] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3326] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3327] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3328] "Primary or metastatic malignant neoplasm involving the uterine corpus and/or the cervix. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3329] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3330] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3331] "Malignant neoplasm originating in the placenta"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3332] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3333] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3334] "Malignant neoplasm of the epididymis"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3335] "Malignant neoplasm involving the spermatic cord."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3336] "A primary or metastatic malignant tumor affecting the scrotum. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3337] "Malignant neoplasm involving the paraurethral glands"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3338] "Abnormal growth of the cells of the orbit with evidence of malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3339] "Abnormal growth of cells comprising the lacrimal gland with malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3340] "A malignant growth of cells within the conjunctiva of the eye."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3341] "A malignant growth of cells within the cornea of the eye."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3342] "Malignant growth of tissues that comprise the choroid body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3343] "Malignant growth of tissues that comprise the lacrimal duct."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3344] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3345] "Primary and secondary (metastatic) malignant tumors that occur in the cerebellum.  Histologic types include medulloblastomas, high grade (WHO Stage III or IV) cerebellar astrocytomas, lymphomas, gangliogliomas, gliosarcomas, and several other subtypes.  The most frequent malignant cerebellar neoplasm of childhood is medulloblastoma. In adults, metastases from other sites are relatively common. Clinical features include ataxia, headache, nausea, dizzyness, nystagmus, diplopia, papilledema, etc. (KEV 8-7-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3346] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3347] "Abnormal malignant growth of the cells that comprise the cranial nerve."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3348] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3349] "Abnormal malignant growth of the cells that comprise the pineal parenchyma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3350] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3351] "Cancer that occurs in endocrine tissue, the tissue in the body that secretes hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3352] "Malignant growth of cells comprising the tissues of the thorax"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3353] "Cancer that has spread from the original (primary) tumor to the lung."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3354] "The spread of the cancer to the mediastinal.  This may be from a primary mediastinal cancer, or from a cancer at a distant site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3355] "The spread of the cancer to the pleura.  This may be from a primary pleura cancer, or from a cancer at a distant site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3356] "Cancer that has spread from the original (primary) tumor to the bone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3357] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3358] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3359] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3360] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3361] "History of plasmacytic leukemia after therapy with no evidence on the peripheral blood or bone marrow of leukemia (normalization of all hematologic parameters)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3362] "Acute lymphocytic leukaemia not growing; responding to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3363] "Chronic lymphocytic leukaemia not growing, responding to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3364] "Acute myeloid leukaemia not growing, responding to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3365] "Chronic myeloid leukaemia not growing; responding to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3366] "Acute monocytic leukaemia not growing, responding to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3367] "Abnormal growth, without malignant characteristics, of the cells that comprise the lips of the mouth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3368] "Abnormal growth, without malignant characteristics, of the cells that comprise the tongue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3369] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3370] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3371] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3372] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3373] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3374] "A tumor in the esophageal lumen which does not invade the esophageal wall and does not metastasize.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3375] "Abnormal growth of the cells that comprise the stomach without evidence of malignancy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3376] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3377] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3378] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3379] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3380] "Abnormal growth of the cells of the tissues contained within the mediastinum e.g. thymus, without evidence of malignancy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3381] "Abnormal growth of the cells comprising the cardiac muscle, valves, and/or vessels without any malignant characteristics"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3382] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3383] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3384] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3385] "Abnormal growth of the cells of the uterus without malignant characteristics noted clinically or histologically."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3386] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3387] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3388] "Abnormal growth of the tissues of the testes without evidence of malignancy"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3389] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3390] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3391] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3392] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3393] "Abnormal growth of the cells of the ureter (upper urinary tract) without malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3394] "A benign abnormal growth of the cells that comprise the bladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3395] "Abnormal growth of the cells of the urethra (lower urinary tract) without malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3396] "Abnormal growth of the cells of the orbit that has no evidence of malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3397] "Abnormal growth of the cells of the lacrimal gland without malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3398] "Abnormal growth of the cells of the conjunctiva without malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3399] "Abnormal growth of the cells of the cornea without malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3400] "Abnormal growth of the cells of the retina without malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3401] "Abnormal growth of the cells of the choroid without malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3402] "Abnormal growth of the cells of the lacrimal duct without malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3403] "A benign growth of the cells that comprise the spinal cord."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3404] "Abnormal benign growth of the cells that comprise the thyroid gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3405] "Abnormal growth of the cells of the adrenal gland without evidence of malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3406] "Benign growth of the cells that comprise the parathyroid gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3407] "A benign growth of the cells that comprise the pineal gland. Despite benign histology, symptoms can be produced due to the location: increased intracranial pressure, endocrine abnormalities, cerebellar and/or brainstem compression.(The latter can produce a constellation of symptoms known as Parinaud's syndrome.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3408] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3409] "Abnormal growth of blood vessels within the retina without malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3410] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3411] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3412] "Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3413] "Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial or invasion of lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3414] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3415] "Stage 0: Tis: Carcinoma in situ; N0: No regional lymph node metastasis; M0: No distant metastasis. (Based on AJCC Cancer Staging).  - 2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3416] "Abnormal cells that are confined to the ducts or lobules in the breast.  There are two forms, called ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3417] "This is a clonal growth of partially transformed cells resulting in morphologically identifiable premalignant lesions.  These are further subdivided into low and high-grade lesions.  The alterations include loss of glandular formation with the development of more anaplastic morphology, nuclear pleomorphism, invasion of the basement membrane, an increase in cell motility, loss of contact inhibition, and angiogenesis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3418] "Stage 0 includes: (Tis, N0, M0) and (Ta, N0, M0).  Tis: Carcinoma in situ.  Ta: Non-invasive verrucous carcinoma.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3419] "Also known as carcinoma in situ of the urinary bladder or high grade intraurothelial neoplasia, this is a flat lesion of the transitional cell epithelium characterized by severe cytologic atypia. This lesion is confined to the urothelium, and is a precursor of invasive transitional cell carcinoma of the bladder. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3420] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3421] "A fluid filled sac within the cerebrum. It is can be congenital, trauma related or secondary to another medical condition for example an infarction."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3422] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3423] "Abnormal fluid filled sac within the conjunctiva."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3424] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3425] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3426] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3427] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3428] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3429] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3430] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3431] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3432] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3433] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3434] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3435] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3436] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3437] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3438] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3439] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3440] "Abnormal fluid filled sac within the thyroid gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3441] "Contact hypersensitivity is an inflammatory response induced by antigen-reactive T cells that are exposed to antigen on the skin surface (epidermis).  Poison ivy is a frequent cause of such reactivity, due to the urushiol from the plant, as are a variety of antigens derived from industrial exposure (e.g. rubber, chromate, nickel).  These antigens induce the appearance of Th1-like T cells, which presumably produce IFN to activate macrophages."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3442] "A disorder caused by a lack of proper nutrition or an inability to absorb nutrients from food."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3443] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3444] "Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3445] "Deposition of calcium in the tissues.  It may be the result of a metabolic disorder or long-standing infection, or it may be associated with the presence of cancer. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3446] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3447] "Includes both malignant and benign neoplasms of the male and female reproductive tracts"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3448] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3449] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3450] "(beh-NINE) A noncancerous growth that does not invade nearby tissue or spread to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3451] "A rare adenocarcinoma of the major and minor salivary glands, originating from basaloid, myoepithelial and ductal cells.  While morphologically resembling basal cell carcinomas, it is a distinct entity.  The tumor is not encapsulated, may invade locally, and less frequently may metastasize.  It usually occurs in older patients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3452] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3453] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3454] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3455] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3456] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3457] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3458] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3459] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3460] "A controversial term, used for renal papillary lesions which measure 1cm or less in diameter and contain small, regular nuclei. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3461] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3462] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3463] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3464] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3465] "A condition in which cancer is spread widely throughout the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3466] "(dis-PLAS-tik NEE-vus) An atypical mole; a mole whose appearance is different from that of a common mole. A dysplastic nevus is generally larger than an ordinary mole and has irregular and indistinct borders. Its color frequently is not uniform and ranges from pink to dark brown; it is usually flat, but parts may be raised above the skin surface."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3467] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3468] "Subependymal Giant Cell Astrocytoma is a benign, slowly growing tumor (WHO grade I) typically arising in the wall of the lateral ventricles and composed of large ganglioid astrocytes. It is the most common CNS neoplasm in patients with Tuberous Sclerosis Complex and typically occurs during the first two decades of life. (WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3469] "Myxopapillary Ependymomas (WHO grade I) are slow growing gliomas which generally occur in young adults and arise almost exclusively in the conus-cauda-filum terminale region. It generally has a favorable prognosis and is characterized histologically by tumor cells arranged in a papillary manner around vascularized mucoid stromal cores. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3470] "Choroid Plexus Papilloma (WHO grade I) is a benign, slow growing tumor which may cause symptoms by blocking CSF pathways. Surgical resection is usually curative. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3471] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3472] "A leiomyosarcoma with a predominance of epithelioid-type cells. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3473] "A rare, highly aggressive variant of leiomyosarcoma, most frequently seen in the uterus and the gastrointestinal tract. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3474] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3475] "A lipoma with prominent vascularity.  The vascular tissue is more abundant at the periphery of the tumor.  It occurs more frequently in younger individuals as a painful subcutaneous nodule, often on the arms. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3476] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3477] "A liposarcoma with areas of pleomorphism, resembling malignant fibrous histiocytoma. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3478] "Medullomyoblastoma (WHO grade IV) is a rare embryonal cerebellar neoplasm with both a primitive neuroectodermal and striated muscle component. Histologically, it is a medulloblastoma with focal myogenic differentiation. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3479] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3480] "A type of tumor that begins in the cells that give rise to sperm or eggs. Germ cell tumors can occur almost anywhere in the body and can be either benign or malignant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3481] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3482] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3483] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3484] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3485] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3486] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3487] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3488] "A heterogeneous group of malignant neoplasms arising in either supportive structures or neuronal tissue. They occur in adolescents and young adults. This tumor shares a number of characteristics with Ewing's sarcoma: it is highly cellular and consists of a monotonous pattern of primitive-appearing round cells. The chest wall is the most common site but the trunk, abdomen, and pelvis are other primary sites. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1660)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3489] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3490] "A very rare congenital condition involving the complex of Wilms' tumor, aniridia, genitourinary abnormalities, and mental retardation. Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation (WAGR) syndrome involves hemizygous deletions of several adjacent genes in chromosome region 11p13. Two or more of the four conditions must be present for an individual to be diagnosed with WAGR Syndrome. The clinical picture varies, depending upon the combination of abnormalities. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3491] "A peripheral (mature) T-cell lymphoma, consisting of usually large anaplastic, CD30 positive cells.  Majority of cases are positive for the anaplastic large cell lymphoma (ALK) protein.  The most frequently seen genetic alteration is a t(2;5) translocation.  Majority of patients present with advanced disease.  The most important prognostic indicator is ALK positivity, which has been associated with a favorable prognosis. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3492] "This is a chronic, recurrent skin disease characterized by spontaneously regressing papules composed of an atypical CD30-positive T-cell population.  The disease is defined as an atypical lymphoproliferative process and usually has a benign course.  However, a minority of cases are clonal and can progress to frank lymphoma.  Low dose methotrexate and psoralen/UVA (PUVA) are the best available therapies.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3493] "An epithelial hyperplasia of the oral mucosa associated with Epstein-Barr virus and found almost exclusively in persons with HIV infection. The lesion consists of a white patch that is often corrugated or hairy. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3494] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3495] "A lymphangioma of the neck"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3496] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3497] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3498] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3499] "(HEP-a-toe-blas-TOE-ma) A type of liver tumor that occurs in infants and children."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3500] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3501] "A group of tumors affecting the female reproductive system, characterised by the presence of epithelial and stromal elements.  It includes the following clinicopathological entities: adenofibroma, adenomyoma, mullerian adenosarcoma, and malignat mixed mesodermal (mullerian) tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3502] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3503] "A malignant neoplasm of the lung composed of tubular structures and immature mesenchymal elements, which may differentiate towards skeletal and smooth muscle, cartilage or a combination of muscle and cartilage.  This is a nodular tumor found in the periphery of the lung.  It can occur at any age.  The prognosis is related to the stage of the disease at the time of resection.  Pulmonary blastoma is divided into three subtypes: epithelial predominant, biphasic, and pleuropulmonary blastoma. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3504] "A lipoma with prominent vascularity.  The vascular tissue is more abundant at the periphery of the tumor.  It occurs more frequently in younger individuals as a painful subcutaneous nodule, often on the arms. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3505] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3506] "The most common type of liposarcoma.  It is composed of small, uniform cells and a rich network of capillaries in a myxoid stroma. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3507] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3508] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3509] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3510] "A benign neoplasm composed of fibroblasts and histiocytes.  Most commonly this tumor is found in the skin and superficial subcutaneous tissues.  Less frequently it can be found in deep soft tissues. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3511] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3512] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3513] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3515] "This is the most common benign breast lesion.  It usually occurs in premenopausal women.  Diagnostic exams and procedures include: clinical exam, imaging (mammography and ultra sound), and tissue biopsy (fine-needle aspiration or core biopsy). -2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3516] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3517] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3518] "A vascular leiomyoma characterized by thick-walled arteries or veins. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3519] "Leiomyomas in multiple anatomic sites. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3522] "A benign or malignant myomatous neoplasm arising from smooth muscle. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3523] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3524] "(jer-mih-NO-ma) The most common type of germ cell tumor in the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3526] "This tumor is made up of derivatives of more than one of the three primary germ cell layers.  The three primary germ cell layers are entoderm, mesoderm, and the ectoderm. -2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3527] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3529] "(HER-tel cell) An uncommon type of thyroid tumor that can be benign or malignant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3531] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3532] "These tumors can also be seen in the scrotum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3534] "polyp consisting of benign neoplastic tissue derived from glandular epithelium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3535] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3536] "(kar-sin-O-ma) A rare type of tumor of the female genital tract in which the inside of the cells looks clear when viewed under a microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3537] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3538] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3539] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3540] "(EYE-let) Cancer arising from cells in the islets of Langerhans, which are found in the pancreas.  Also called endocrine cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3541] "An adenocarcinoma of the breast arising from the lobules.  This is a relatively uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas and is often bilateral or multifocal. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3542] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3543] "A malignant neuroendocrine tumor composed of cells containing secretory granules that stain positive for NSE and chromogranin.  Tumor cells are often round and form clusters or trabecular sheets.  Representative examples are carcinoid tumor, small cell carcinoma, and Merkel cell carcinoma. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3544] "A highly malignant type of cancer typically found in glandular cells that line the digestive organs. The cells resemble signet rings when examined under a microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3545] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3546] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3547] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3548] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3549] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3550] "(kar-sin-O-mas) A group of lung cancers in which the cells are large and look abnormal when viewed under a microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3551] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3552] "(SER-vih-kul in-tra-eh-pih-THEEL-ee-ul NEE-o-play-zha) CIN. A general term for the growth of abnormal cells on the surface of the cervix. Numbers from 1 to 3 may be used to describe how much of the cervix contains abnormal cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3553] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3554] "A neoplastic proliferation of basal cells in the epidermis (part of the skin) or other anatomic sites (most frequently the salivary glands).  The basal cell neoplastic proliferation in the epidermis results in basal cell carcinomas.  The basal cell neoplastic proliferation in the salivary glands can be benign, resulting in basal cell adenomas or malignant, resulting in basal cell adenocarcinomas. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3555] "A small, often impalpable benign papilloma arising in a lactiferous duct and frequently causing bleeding from the nipple. (Stedman, 25th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3556] "A benign or malignant neoplasm arising from mesothelial cells.  Mesothelial cells are the lining cells of the pleura and peritoneum. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3557] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3558] "Ganglioglioma (WHO grade I or II) and Gangliocytoma (WHO grade I) are well differentiated, slow growing neuroepithelial neoplasms composed of neoplastic, mature ganglion cells either alone (gangliocytoma), or in combination with neoplastic glial cells (ganglioglioma). Some Gangliogliomas show anaplastic features in their glial component and are considered to be WHO grade III (see 'Anaplastic Ganglioglioma). There are rare cases of newly diagnosed Gangliogliomas with grade IV (Glioblastoma) changes in the glial component. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3559] "Olfactory Neuroblastomas are rare neuroectodermal tumors. They are assumed to originate from olfactory receptor cells high in the nasal cavity. Unless resected at an early stage, they carry a poor prognosis. Microscopically, their typical pattern is neuroblastic with occasional formation of rosettes, but some lesions show neuroendocrine differentiation. When this pattern dominates the histology, the diagnosis of a neuro-endocrine carcinoma may occur. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3560] "Ganglioneuroblastoma is a type of Neuroblastic Tumor. There are two subtypes: Ganglioneuroblastoma, intermixed (Schwannian stroma-rich) and Ganglioneuroblastoma, nodular (composite, Schwannian stroma-rich/stroma-dominant and stroma-poor). (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3561] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3562] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3563] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3564] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3565] "Subependymoma (WHO grade I) is a benign, slow growing neoplasm which is typically attached to a ventricular wall. It is composed of glial tumor cell clusters embedded in an abundant fibrillary matrix with frequent microcystic change. Some lesions have the histological features of both subependymoma and ependymoma. It is often detected incidentally and has a very favorable prognosis. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3566] "A type of glioma (cancer of the brain that comes from glial, or supportive, cells)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3567] "A nerve that has become thick and misshapen due to the abnormal growth of cells and tissues that cover the nerve."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3568] "An uncommon, highly aggressive malignant tumor, arising from the peripheral nerves and affecting mostly adults in their third to sixth decades of life.  It occurs usually in medium-sized and large nerves of the buttock, thigh, upper arm, or the paraspinal region.  It may be associated with neurofibromatosis 1 (NF1). -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3569] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3570] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3571] "A histologically benign tumor, usually cystic with a vascular mural nodule, that is most often found in the cerebellum though it has been reported at other sites within the neuraxis. It is associated with von Hippel-Lindau disease (VHL gene located on chr 3p25-26)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3572] "A type of skin cancer in which the cells do not make melanin. Skin lesions are often irregular and may be pink, red, or have light brown, tan, or gray at the edges."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3573] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3574] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3575] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3576] "A malignant tumor of either the central nervous system (CNS) or the kidney. Malignant rhabdoid tumors of the CNS often have an abnormality of chromosome 22. These tumors usually occur in children younger than 2 years."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3577] "A tumor derived from cells that release a hormone in response to a signal from the nervous system.  Some examples of neuroendocrine tumors are carcinoid tumors, islet cell tumors, medullary thyroid carcinoma, and pheochromocytoma.  These tumors secrete hormones in excess, causing a variety of symptoms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3578] "A benign or malignant, primary or metastatic tumor affecting soft tissues or bone.  Representative examples of benign tumors include lipoma and hemangioma; malignant tumors include leiomyosarcoma and osteosarcoma.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3579] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3580] "A carcinoma which has metastasized from an unknown primary source"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3581] "Cancer that has spread from the original (primary) tumor to the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3582] "A condition in which cancer cells spread into the meninges (membranes that surround the brain and spinal cord)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3583] "A condition in which fluid containing cancer cells collects in the abdomen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3584] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3585] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3586] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3587] "A plasma cell neoplasm that secretes an abnormal immunoglobulin, which deposits in various tissues and forms a beta-pleated sheet structure that binds Congo red dye with characteristic birefringence.  The sites of involvement include heart, liver, kidney, gut, tongue, nerves, and bone. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3588] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3589] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3590] "X-linked agammaglobulinemia.  An immunodeficiency state characterized (usually) by profoundly low concentrations of serum immunoglobulins of all classes, although occasionally significant amounts of one or more isotypes can be found.  The fundamental defect in XLA affects early lineage B cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3591] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3592] "(LEE-zhun) An area of abnormal tissue change."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3593] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3594] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3595] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3596] "A rare tumor containing unequivocal elements of both hepatocellular and cholangiocarcinoma that are intimately admixed.  This tumor should be distinguished from separate hepatocellular carcinoma and cholangiocarcinoma arising in the same liver.  The prognosis of this tumor is poor. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3597] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3598] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3599] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3600] "Having no signs or symptoms of disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3601] "(ah-TAK-sik) Awkward, uncoordinated walking."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3602] "The term used when liquid backs up into the esophagus from the stomach."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3603] "The inability to produce children."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3604] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3605] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3607] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3608] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3609] "A rare benign condition, characterized by an exophytic papillary growth in the urinary bladder with a central fibrovascular core.  The latter is lined by normal urothelium. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3610] "Malignant cancerous cyst found in the ovary"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3611] "A malignant tumor arising from the epithelium of the gallbladder.  It is associated with the presence of gallstones.  Clinical symptoms are not specific and usually present late in the course.  Morphologically, most gallbladder carcinomas are adenocarcinomas; squamous cell carcinomas, adenosquamous carcinomas, signet ring carcinomas, and undifferentiated carcinomas can also occur. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3612] "Leukemia in a newborn"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3613] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3614] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3615] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3616] "A disease in which malignant (cancer) cells are found in the tissues of the pancreas. Also called exocrine cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3617] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3618] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3619] "A complication of some cancer therapies in which the lining of the digestive system becomes inflamed. Often seen as sores in the mouth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3620] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3621] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3622] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3623] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3624] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3625] "AIDS in patients under thirteen years of age; mostly acquired perinatally from HIV infected mother; some contracted by blood transfusion or sexual abuse."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3626] "A carcinoma involving the extrahepatic bile ducts.  The majority are adenocarcinomas. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3627] "A tumor arising from the ependymal lining of the ventricles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3628] "A rare malignant tumor of the breast, affecting mostly older men.  It accounts for less than 1% of all malignancies in men.  The most common histologic type is invasive ductal carcinoma.  Most patients are treated with mastectomy. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3629] "A benign neoplasm arising from the ductal breast epithelium.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3630] "Adenomatous colon polyps are considered to be precursor lesions of colon cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3631] "Any closed cavity or sac, normal or abnormal, lined by epithelium, and especially one that contains a liquid or semisolid material. (Dorland, 27th ed). This concept refers specifically to a cyst formed within the epididymis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3632] "The most common mesenchymal tumor of the esophagus.  It occurs more frequently in males than females, and has a median age distribution between 30 and 35 years.  It involves the lower esophagus.  Dysphagia is the usual complaint.  Esophageal leiomyomas vary in size from a few millimeters up to 10cm in diameter.  The prognosis is good.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3633] "A carcinoma involving the fallopian tube which is attached to the uterine corpus (uterine body).  It may be a primary carcinoma, arising from the epithelium of the fallopian tube or, more commonly secondary from ovarian origin.  Most patients are postmenopausal, and postmenopausal bleeding is the most frequently seen symptom.  Morphologically, the majority of fallopian tube carcinomas are serous or endometrioid adenocarcinomas. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3634] "GIST. A type of tumor that usually begins in cells in the wall of the gastrointestinal tract.  It can be benign or malignant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3635] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3636] "Extensive infiltration of the lymphatic vessels by cancer cells, resulting in widespread cancer dissemination.  The lymphatic vessels appear as palpable, cord-like structures, especially in skin areas overlying the carcinoma.--2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3637] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3638] "Brenner tumors constitute between 1% and 2% of all ovarian neoplasms.  The average age at presentation is about 50 years.  Grossly Brenner tumor is usually unilateral, firm and white or yellowish.  Microscopically it consists of solid and cystic nests of epithelial cells resembling transitional epithelium surrounded by an abundant stromal component of dense, fibroblastic nature. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3639] "Benign and malignant germ cell tumors which arise in the ovaries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3640] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3641] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3642] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3643] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3644] "(an-a-PLAS-tik) A rare, aggressive type of thyroid cancer in which the malignant (cancer) cells look very different from normal thyroid cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3645] "(MED-yoo-LAIR-ee) Cancer that develops in C cells of the thyroid. The C cells make a hormone (calcitonin) that helps maintain a healthy level of calcium in the blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3646] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3647] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3648] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3649] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3650] "Any closed cavity or sac, normal or abnormal, lined by epithelium, and especially one that contains a liquid or semisolid material. (Dorland, 27th ed) present in the skin"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3651] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3652] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3653] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3654] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3655] "Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity.  It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea, that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion.  PID may be either symptomatic or asymptomatic.  It may cause infertility and it may raise the risk of ectopic pregnancy.  PID is a disease associated with HIV infection."                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3656] "Having too little oxygen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3657] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3658] "A clonal disorder characterized by the secretion of a mu heavy chain that lacks a variable region.  Most patients present with slowly progressive chronic lymphocytic leukemia (CLL).  In contrast to most cases of CLL, Mu heavy chain disease is associated with hepatosplenomegaly and absence of lymphadenopathy. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3659] "Psychological craving for or habituation to the use of a chemical substance which may or may not be accompanied by physical dependency. Used for animal or human populations. Compare DRUG ADDICTION. (PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3660] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3661] "remainder of a tumor or a neoplasm/cancer after primary, potentially curative therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3662] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3663] "(MAK-ro-GLOB-u-li-NE-me-uh) A condition in which the blood contains high levels of large proteins and is too thick to flow through small blood vessels. One type is Waldenstrom's macroglobulinemia, which is a type of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3664] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3665] "(KOM-pownd NEE-vus) A type of mole formed by groups of nevus cells found in the epidermis and dermis (the two main layers of tissue that make up the skin)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3666] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3667] "A tumor composed of two or more glial cell types (astrocytes, ependymal cells, and oligodendrocytes). --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3668] "A rare WHO grade III meningioma defined by the presence of a perivascular pseudopapillary pattern in at least part of the tumor. They are clinically aggressive. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3669] "Inflammation of the small intestine caused by radiation exposure"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3670] "The adrenal glands are composite endocrine organs located on the superomedial aspects of the kidneys.  It is comprised of the adrenal cortex and the adrenal medulla.  Adenoma is a benign epithelial neoplasm that forms glandular patterns.  The most common adrenal masses are adrenal adenomas.  Cortical adenomas are benign neoplasms that can arise from any of the cortical layers.  These tumors can be associated with the over production of glucocorticoids, androgenic or estrogenic steroids or mineralcorticoids.  Diagnosis is accomplished through imaging.  Treatment: Surgical resection is the definitive treatment and is curative.  Adrenal masses that are 4cm or less and are of low attenuation can be conservatively followed with follow-up CT scans.  Providing the patient does not have a known cancer or hormonal imbalances.  Also, larger tumors that weigh between 50 to 100 g that otherwise have a benign appearance necessitate long term follow up. - 2003"   
 [3671] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3672] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3673] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3674] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3675] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3676] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3677] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3678] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3679] "A neuroendocrine carcinoma composed of small malignant cells which are often said to resemble \"oat cells\" under the microscope.  Small cell carcinoma most often affects the lungs.  Clinically, this is often a rapidly growing cancer that spreads to distant sites early."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3680] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3681] "A carcinoma arising from the vaginal epithelium.  The majority of vaginal carcinomas are squamous cell carcinomas.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3682] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3683] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3684] "A rare condition that stimulated chronic radiodermatitis.  It is considered a variant of mycosis fungoides.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3685] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3686] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3687] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3688] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3689] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3690] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3691] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3692] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3693] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3694] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3695] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3696] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3697] "Any closed cavity or sac, normal or abnormal, lined by epithelium, and especially one that contains a liquid or semisolid material. (Dorland, 27th ed). This concept refers specifically to a cyst formed within the pharyngeal structures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3698] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3699] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3700] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3701] "The syndrome of polyposis coli, colon cancer and brain tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3702] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3703] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3704] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3705] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3706] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3707] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3708] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3709] "Colloid cysts i.e. cysts filled with gelatinous material, in the central nervous system often are found in the third ventricle. Due to their location, chronic or intermittent hydrocephalus can result. Case reports of sudden death due to acute obstructive hydrocephalus are in the literature. Colloid cysts are benign lesions that should be considered for neurosurgical resection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3710] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3711] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3712] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3713] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3714] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3715] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3716] "A neoplastic or non-neoplastic lesion arising from the gastric mucosa.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3717] "A intraepithelial neoplasia (dysplasia) that arises in either the native gastric mucosa or in metaplastic gastric epithelium.  It has a flat, polypoid or slightly depressed growth pattern.  It is graded as low grade (mild dysplasia) or high grade (moderate dysplasia and carcinoma in situ).  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3718] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3719] "This is a descriptive term referring of a mass of tissue that bulges or projects into the lumen of the anal lumen.  The mass is macroscopically visible and may either have a broad base attachment to the rectal wall, or be on a pedunculated stalk.  These may be benign or malignant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3720] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3721] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3722] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3723] "A buildup of uric acid (a byproduct of metabolism) in the blood; a side effect of some anticancer drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3724] "An autosomal recessive deficiency of the purine salvage enzyme adenosine deaminase which results in Severe Combined Immunodeficiency Disease (SCID).  The most common form of SCID, accounting for about 50% of autosomal recessive cases.  The first disease for which gene therapy was applied."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3725] "PNP reversibly catalyzes the phosphorolysis of the purine nucleosides, (deoxy)inosine and (deoxy)guanosine, to their respective purine bases and the corresponding ribose-1-phosphate.  Deficiency in this enzyme is an autosomal recessive cause of combined immunodeficiency."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3726] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3727] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3728] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3729] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3730] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3731] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3732] "Abnormal fluid filled sac within the kidney, either acquired or congenital."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3733] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3734] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3735] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3736] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3737] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3738] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3739] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3740] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3741] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3742] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3743] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3744] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3745] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3746] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3747] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3748] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3749] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3750] "Abnormal secretion of antidiuretic hormone in conjunction with neoplastic growth occurring anywhere in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3751] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3752] "An immunodeficiency state characterized by very low serum IgG and IgA but either a normal or, more frequently, a markedly elevated concentration of polyclonal IgM."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3753] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3754] "Also known as epidemic Kaposi's sarcoma, this is a malignant vascular tumor affecting individuals suffering from AIDS.  It can occur in the skin or internal organs. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3755] "Stage II includes: IIA (T3, N0, M0); IIB (T4, N0, M0).  T3: Tumor invades through the muscularis propria or into non-peritonealized pericolic or perirectal tissues.  T4: Tumor directly invades other organs or structures, and/or perforates visceral peritoneum.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3756] "Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3757] "Cancer has spread to other organs of the body, most often the bones, lungs, liver, or brain; or tumor has spread locally to the skin and lymph nodes inside the neck, near the collarbone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3758] "A plasma cell disorder in which an abnormal amount of a single immunoglobulin is present in the serum. Up to 25% of cases of monoclonal gammopathy of undetermined significance (MGUS) progress to a B-cell malignancy or myeloma. MGUS may occur in conjunction with various carcinomas, chronic inflammatory and infectious conditions, and other diseases. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3759] "A glioma consisting of neoplastic cells that resemble the undifferentiated cells of the primitive medullary tube. The neoplastic cells are compactly arranged, round or ovoid, with hyperchromatic nuclei in relatively scant cytoplasm, and lie in small and poorly defined groups or, occasionally, in a pseudorosette pattern. (From Stedman, 25th ed) Medulloblastomas represent almost one third of all childhood nervous system neoplasms. (Kaye AH, Laws ER Brain Tumors. p. 561 Churchill)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3760] "Cancer of the colon reemerging after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3761] "An esophageal cancer which has reappeared after a period of remission or after presumed treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3762] "Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3763] "A rare type of breast cancer in which breast cancer cells block the lymph vessels in the skin of the breast. The breast becomes red, swollen, and warm, and the skin of the breast may appear pitted or have ridges."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3764] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3765] "Kidney cancer that has spread beyond the kidney to lymph nodes or organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3766] "Gastric adenocarcinoma is an adenocarcinoma arising from the stomach glandular epithelium.  Gastric adenocarcinoma is primarily a disease of older individuals, most commonly develops after a long period of atrophic gastritis and is strongly associated with Helicobacter Pylori infection.  The lack of early symptoms often delays the diagnosis of gastric cancer.  The majority of patients present with advanced tumors which have poor rates of curability.  Microscopically, two important histologic types of gastric adenocarcinoma are recognized: the intestinal and diffuse type.  The overall prognosis of gastric adenocarcinomas is poor, even in patients who receive a \"curative\" resection (adapted from Sternberg's Surgical Pathology, 3rd ed., 1999). --2002"                                                                                                                                                                                                            
 [3767] "A malignant tumor that occurs in children.  Representative examples include soft tissue and bone sarcomas (e.g. osteosarcoma) and embryonal neoplasms (e.g. hepatoblastoma and rhabdoid tumor). -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3768] "Cancer cells have spread to the lining of the bladder or rectum or to distant parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3769] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3770] "The reemergence of gall bladder cancer after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [3771] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3772] "This is a pituitary tumor, which most frequently presents in children, but can occur throughout life.  It arises in cells derived from Rathke's pouch.  The tumor may interfere with pituitary function.  Findings may include endocrine disturbances and pressure symptoms.  Diagnostic procedure(s) include: MRI is the scan of choice.  Standard treatment options include: surgery alone if totally resectable or debulking surgery plus radiation therapy if unresectable. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3773] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3774] "Cancer has spread to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [3775] "Cancer that arises in the head or neck region (in the nasal cavity, sinuses, lip, mouth, salivary glands, throat, or larynx [voice box])."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3776] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3777] "Cancer that has spread from the original (primary) tumor to the central nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3778] "Bone cancer comprises two major malignancies: Primary bone cancer that started in the bones and secondary bone cancer that has spread to the bones from somewhere else in the body.  Primary bone cancers include osteosarcoma, chondrosarcoma, and Ewing's sarcoma.  Primary bone cancer is most common in children and adolescents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3779] "A carcinoma arising from the ducts.  While ductal carcinomas can arise at other sites, this term is universally used to refer to carcinomas of the breast.  Ductal carcinomas account for about two thirds of all breast cancers.  Two types of ductal carcinomas have been described: Ductal carcinoma in situ (DCIS) and infiltrating ductal carcinoma.  The latter often spreads to the axillary lymph nodes.  The two forms of ductal carcinoma often coexist. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3780] "(LOB-yoo-lar kar-sin-O-ma in SYE-too) LCIS. Abnormal cells found in the lobules of the breast. This condition seldom becomes invasive cancer; however, having lobular carcinoma in situ increases one's risk of developing breast cancer in either breast."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3781] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3782] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3783] "An osteosarcoma characterised by the presence of atypical cartilage of variable cellularity.  It may or may not be associated with the presence of myxoid areas or focal bone formation. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3784] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3785] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3786] "Squamous cell carcinomas of the esophagus typically arise after many years of tobacco and alcohol abuse and are exceedingly rare before the age of 30.  The median age is around 65 in both males and females.  Esophageal squamous cell carcinoma is located mostly in the middle and lower third of the esophagus.  Grossly, polypoid, ulcerated, plaque-like and occult lesions have been described.  The microscopic features are the same as in other squamous cell carcinomas.  Any degree of differentiation may occur, and variation within a single tumor is common.  The prognosis of esophageal squamous cell carcinomas is poor. --2002"                                                                                                                                                                                                                                                                                                                                                
 [3787] "Esophageal adenocarcinoma is a malignant tumor with glandular differentiation arising predominantly from Barrett mucosa in the lower third of the esophagus.  Rare examples of esophageal adenocarcinoma deriving from ectopic gastric mucosa in the upper esophagus have also been reported.  Grossly, esophageal adenocarcinomas are similar to esophageal squamous cell carcinomas.  Microscopically, adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular.  The prognosis is poor.  --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3788] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3789] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3790] "Cervical squamous cell carcinoma usually evolves from a precancerous cervical lesion.  Increased numbers of sexual partners and human papilloma virus(HPV) infection are risk factors for cervical squamous cell carcinoma.  The following histologic patterns have been described: Conventional squamous cell carcinoma, papillary squamous cell carcinoma, transitional cell carcinoma, lymphoepithelioma-like carcinoma, verrucous carcinoma, condylomatous carcinoma and spindle cell carcinoma.  Survival is most closely related to the stage of disease at the time of diagnosis. --2002"                                                                                                                                                                                                                                                                                                                                                                                                    
 [3791] "Cervical adenocarcinomas account for approximately 15% of invasive cervical carcinomas.  Increased numbers of sexual partners and human papilloma virus (HPV) infection are risk factors.  Grossly, advanced cervical adenocarcinoma may present as an exophytic mass, an ulcerated lesion, or diffuse cervical enlargement.  Microscopically, the majority of cervical adenocarcinomas are of the endocervical (mucinous) type. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3792] "A malignant neoplasm derived from the transitional epithelium of the urinary tract (urinary bladder, ureter, urethra, or renal pelvis).  It is frequently papillary.  Urothelial transitional cell carcinomas are graded 1 to 3 or 4 according to the degree of cellular differentiation and architectural pattern.  Grade 1 appears histologically benign but is liable to recurrence. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3793] "Bladder squamous cell carcinomas arise from metaplastic bladder epithelium and represent less than 10% of bladder carcinomas.  The exception is the Middle East along the Nile Valley, where they represent the most common form of carcinomas because of the endemic nature of schistomiasis.  Bladder squamous cell carcinomas are often associated with long-standing chronic inflammation of the bladder and have a poor prognosis.  The diagnosis of squamous cell carcinoma of the bladder should be reserved for those tumors that are predominantly keratin forming. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                
 [3794] "Primary bladder adenocarcinomas are rare, arise from metaplastic bladder epithelium and are frequently associated with long-standing local irritation.  The majority originate from the trigone and the posterior wall. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3795] "The most common type of renal cell carcinoma, characterized by a loss of genetic material of the short arm of chromosome 3.  The most common symptom at the time of diagnosis is hematuria.  The tumor has a golden-yellow color because of the abundance of intracytoplasmic lipid.  This is a clinically aggressive type of renal cell carcinoma. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3796] "The reemergence of laryngeal cancer after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3797] "(PAP-i-lair-ee) Cancer that develops from cells in the thyroid and forms small finger-like projections.  The most common type of thyroid cancer, it grows slowly, is more common in women than in men, and often develops before age 40."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3798] "A myelodysplastic syndrome characterized by an anemia in which 15% or more of the erythroid precursors are ringed sideroblasts.  The ring sideroblast is an erythroid precursor in which one third or more of the nucleus is encircled by granules which are positive for iron stain.  It occurs primarily in older individuals.  The median survival exceeds 5 years.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3799] "A subtype of acute myeloid leukemia with multilineage dysplasia.  This subtype includes the vast majority of refractory anemia with excess blasts in transformation cases.  This latter term used to be part of the French-American-British classification scheme of myelodysplastic syndromes and has been eliminated from the WHO classification.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3800] "A rare neuroendocrine tumor thought to arise from enterochromaffin cells.  It is difficult to determine histologically whether the tumor in question is benign or malignant.  Though these tumors can occur almost anywhere in the body, the most common sites are, in order, the appendix, the small intestine, rectum and bronchus.  They can be detected at any age though the mean age is 55 years with a median of 57 years.  Carcinoid syndrome, if present, is associated with diarrhea, cutaneous flushing, asthma, and valvular heart disease.  If the carcinoid syndrome is not present, the presentation is related to the location of the tumor."                                                                                                                                                                                                                                                                                                                                       
 [3801] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3802] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3803] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3804] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3805] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3806] "Squamous cell carcinoma is the most common type of laryngeal carcinoma.  The site of origin within the larynx influences the symptoms, histologic characteristics, and clinical behavior of squamous cell carcinoma.  The laryngeal squamous cell carcinomas can be glottic, supraglottic, and transglottic.  Glottic carcinoma is the most frequent form of laryngeal carcinoma in the United States.  Microscopically, squamous cell carcinomas of the larynx are similar in their appearance to squamous cell carcinomas arising elsewhere (adapted from Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999). --2002"                                                                                                                                                                                                                                                                                                                                                                      
 [3807] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3808] "Cancers that are found in HIV infected patients.  The most common AIDS-related cancers are Kaposi's sarcoma, and non-Hodgkin's lymphoma.  Other AIDS-related cancers include malignant neoplasms in lung and bronchus, oral, cervical, digestive systems and Hodgkin's disease.  (N J Med 2001 Jan;98(1):27-36)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3809] "Pilocytic Astrocytoma, the most common glioma in children, is a WHO grade I astrocytic tumor. It is a generally well circumscribed, slowly growing, often cystic, astrocytoma. It is histologically characterized by a biphasic pattern with varying proportion of compacted bipolar cells which may have Rosenthal fibers (tapered corkscrew-shaped, brightly eosinophilic, intracytoplasmic hyaline masses) and loose textured multipolar cells with microcysts and granular bodies. (WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3810] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3811] "Anaplastic Ependymoma (WHO grade III) is a malignant glioma of ependymal origin with accelerated growth and an unfavorable clinical outcome, particularly in children. Anaplastic Ependymomas show high mitotic activity, often accompanied by microvascular proliferation and pseudo-palisading necrosis. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3812] "A malignant tumor with characteristics of both oligodendroglioma and astrocytoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3813] "A WHO grade III meningioma exhibiting histological features of frank malignancy that exceed the abnormalities present in atypical meningioma. Anaplastic meningiomas are usually fatal, with median survival of less than 2 years. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3814] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3815] "Leakage of drug from a vein into the surrounding tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [3816] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3817] "A benign growth that originates from the arachnoidal cap cells or the meningothelial cells, rarely invading brain parenchyma. The usual form of treatment is attempted gross total neurosurgical resection. These tumors tend to recur if incompletely excised (Kaye AH, Laws ER Brain Tumors Churchill Livingstone 1995)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3818] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3819] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3820] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3821] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3822] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3823] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3824] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3825] "A benign or malignant mesenchymal neoplasm arising from smooth or skeletal muscle. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3826] "(pros-TAT-ik in-tra-eh-pih-THEEL-ee-ul NEE-o-play-zha) PIN.  Noncancerous growth of the cells lining the internal and external surfaces of the prostate gland.  It is an important sign that prostate cancer may develop."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [3827] "Abnormal secretion of hormones in conjunction with neoplastic growth occurring anywhere in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3828] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3829] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3830] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3831] "A benign fibrohistiocytic neoplasm characterized by a localized collection of histiocytes containing lipid.  Xanthomas usually occur in the skin and subcutaneous tissues, but occasionally they may involve the deep soft tissues.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3832] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3833] "A rare malignant tumor derived from meningeal connective tissue.  This neoplasm tends to grow rapidly and may metastasize outside the central nervous system. (From Donnet et al., J Neurooncol 1999 Mar;42(1):79-83)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3834] "A B-cell non-Hodgkin's lymphoma composed of large noncleaved cells. This is a subtype of diffuse large B-cell non-Hodgkin's lymphoma. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3835] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3836] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3837] "Coloration of the skin; sign of inflammation"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3838] "Perforation; a hole made through a part or substance. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3839] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3840] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3841] "A polyp found mainly in the stomach and colon.  Microscopically, it is characterized by elongated, serrated crypts lined by proliferative epithelium.  Hyperplastic polyps are traditionally considered non-neoplastic, but ras mutation is common, clonality has been demonstrated and biochemical abnormalities and epidemiological associations that occur in colorectal adenomas and carcinomas have been found (WHO Tumors of the Digestive System, 2000).  However, a number of Gastrointestinal Pathologists reject the idea that hyperplastic polyps represent true neoplasms. --2002"                                                                                                                                                                                                                                                                                                                                                                                                      
 [3842] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3843] "(dis-PLAY-zha) Cells that look abnormal under a microscope but are not cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3844] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3845] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3846] "The development of numerous polyps (growths that protrude from a mucous membrane)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [3847] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3848] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3849] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3850] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3851] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3852] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3853] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3854] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3855] "Squamous cell carcinomas with morphologically prominent production of keratin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [3856] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3857] "(LIM-fo-EP-ih-THEE-lee-O-ma) A type of cancer that begins in the tissues covering the nasopharynx (the upper part of the throat behind the nose)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3858] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3859] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3860] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3861] "A benign tumor that can be difficult to differentiate from basal cell carcinoma"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [3862] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3863] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3864] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3865] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3866] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3867] "Schneiderian papillomas are benign neoplasms that are associated with three key characteristics: tendency to recur, capacity for local destruction, and association with squamous cell carcinoma. They are classified into inverting, fungiform, and oncocytic varieties. The inverting and fungiform varieties are the most common, and the inverting variety has the highest rate of association with malignancy. (from J La State Med Soc 1997;149:310-5)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3868] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3869] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3870] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3871] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3872] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3873] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3874] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3875] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3876] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3877] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3878] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3879] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3880] "Fibrolamellar carcinoma is a distinctive morphologic variant of liver cell carcinoma seen predominantly in young patients without cirrhosis and associated with favorable prognosis.  The tumor cells are polygonal and deeply eosinophilic embedded in a fibrous stroma.  Over half of the fibrolamellar carcinomas are resectable, and the cure rate is about 50%. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3881] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3882] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3884] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3885] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3886] "A rare tumor thought to arise from enterochromaffin cells.  It is a neuroendocrine tumor.  It is difficult to determine histologically whether the tumor in question is benign or malignant.  Though these tumors can occur almost anywhere in the body, the most common sites are, in order, the appendix, the small intestine, rectum and bronchus.  They can be detected at any age though the mean is 55 years with a median of 57 years.  If the carcinoid syndrome is not present, the presentation is related to the location.  Carcinoid syndrome, if present, is associated with diarrhea, cutaneous flushing, asthma, and valvular heart disease."                                                                                                                                                                                                                                                                                                                                        
 [3887] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3888] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3889] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3891] "A type of polyp that grows in the colon and other places in the gastrointestinal tract and sometimes in other parts of the body. These adenomas may become malignant (cancerous)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3892] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3893] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3894] "A type of carcinoma that comprises a minority of renal cell carcinomas.  It is characterized by loss of chromosomes 1 and Y.  Based on the cytoplasmic characteristics of the neoplastic cells, this type of carcinoma is classified as classic (typical) or eosinophilic.  It has a much better prognosis than other renal cell carcinomas.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3895] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3896] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3897] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3898] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3899] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3900] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3901] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3902] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3903] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3906] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3907] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3910] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3911] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3912] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3913] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3914] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3915] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3916] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3917] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3918] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3919] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3920] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3922] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3923] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3924] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3927] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3928] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3929] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3932] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3933] "The existence and clinical significance of a borderline category in the mucinous tumors is not as well-defined as for their serous counterpart.  Hart and Norris proposed that a mucinous tumor should be classified as borderline when stromal invasion is uncertain and the atypical lining epithelium is less than four cells in thickness. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [3934] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3935] "A type of ductal carcinoma in situ (very early-stage breast cancer)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [3936] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3937] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3938] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3939] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3940] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3941] "Invasive ductal carcinoma is the most common type of invasive breast carcinoma (accounting for approximately 70% of breast carcinomas).  The gross appearance is usually typical with an irregular stellate outline.  Microscopically, randomly arranged epithelial elements are seen.  When large sheets of malignant cells are present, necrosis may be seen.  With adequate tissue sampling, in situ carcinoma can be demonstrated in association with the infiltrating carcinoma.  The in situ component is nearly always ductal but occasionally may be lobular or both. --2002"                                                                                                                                                                                                                                                                                                                                                                                                               
 [3942] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3943] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3944] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3945] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3946] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3948] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3949] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3950] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3951] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3952] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3953] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3954] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3955] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3956] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3957] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3958] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3960] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3961] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3963] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3965] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3966] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3968] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3969] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3970] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3971] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3972] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3973] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3974] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3975] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3976] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3977] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3978] "(JUNK-shun-ul NEE-vus) A mole found in the junction (border) between the epidermis and dermis layers of the skin. These moles may be pigmented and slightly raised, and have a higher risk of developing into malignant melanoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [3979] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3980] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3981] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3982] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3984] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3985] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3986] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3988] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3989] "A benign tumor that arises from mesenchymal cells in extra skeletal sites.  The most common types are lipomas (from adipose or fatty tissues), hemangiomas (from vascular tissues), and benign fibrous histiocytoma (from fibrohistiocytic tissues). -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [3990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3991] "A fibrosarcoma, occurring in infants and young children, sharing identical morphologic features with adult fibrosarcoma.  The prognosis is generally much more favorable than for adult fibrosarcoma, and it rarely metastasizes.  It usually affects the superficial and deep soft tissues of the extremities.  The majority of infantile fibrosarcomas carry the t(12;15)(p13;q26) translocation. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [3992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3993] "An intermediate cutaneous fibrohistiocytic neoplasm, characterized by pleomorphic spindle cells, usually affecting the actinic-damaged skin of the elderly.  The tumor presents as a single cutaneous nodule which is often ulcerated.  Microscopically, it is indistinguishable from pleomorphic forms of malignant fibrous histiocytoma, and it is regarded by many experts as a superficial form of the latter.  The vast majority of patients have an excellent prognosis following conservative therapy.  Recurrences are infrequent, and metastasis is rare. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                         
 [3994] "A sarcoma characterized by the presence of fibroblasts and atypical, pleomorphic cells.  Cellular pleomorphism and a storiform pattern are the microscopic characteristics that define this malignant tumor.  Although it can occur in any part of the body, the lower extremity is the most common site of involvement.  This is generally an aggressive sarcoma, although certain morphologic variants (e.g., myxoid malignant fibrous histiocytoma) tend to have a more favorable prognosis. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [3995] "A benign or malignant tumor composed of adipose (fatty) tissue. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [3996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3998] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [3999] "An aggressive type of liposarcoma, composed of cells larger than the ones seen in the myxoid liposarcoma.  Usually, a high mitotic rate is present. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4001] "A lipoma with prominent vascularity.  The vascular tissue is more abundant at the periphery of the tumor.  It occurs more frequently in younger individuals as a painful subcutaneous nodule, often on the arms. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [4002] "A benign disorder characterized by the presence of multiple lipoblastomas. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4004] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4005] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4007] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4008] "A benign or malignant mesenchymal neoplasm arising from skeletal (striated) muscle. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4009] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4010] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4011] "A primary renal tumor notable for clusters of pale stained tumor cells separated by vascular septa.  This tumor is known to metastasize to lung, bone and brain.  (Pizzo and Poplack, Principles and practice of pediatric Oncology, 3rd edition.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4012] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4013] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4014] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4015] "Malignant Brenner tumor is a Brenner tumor characterised by a cytologically malignant cell population and stromal invasion. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4016] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4017] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4018] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4019] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4020] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4021] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4022] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4023] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4024] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4025] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4026] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4027] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4028] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4029] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4030] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4031] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4032] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4033] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4034] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4035] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4036] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4037] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4038] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4039] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4040] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4041] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4042] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4043] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4044] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4045] "An uncommon malignant neoplasm arising from pericytes.  Distinction between benign and malignant hemangiopericytoma may be difficult or even impossible on morphologic grounds alone. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4046] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4047] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4048] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4049] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4050] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4051] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4052] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4053] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4054] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4055] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4056] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4057] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4058] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4059] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4060] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4061] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4062] "Gliomatosis cerebri (WHO grade II) is a diffuse glial tumor which infiltrates the brain, extensively, involving more than two lobes. It is frequently bilateral and often extends to the infratentorial structures, even to the spinal cord. It is probably of astrocytic origin, although GFAP expression may be scant or absent. (Adapted form WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4063] "Papillary Ependymoma is a rare variant of Ependymoma characterized by well formed papillae. Tumor cell processes abutting capillaries are usually GFAP-positive.  Differential diagnoses include Choroid Plexus Papilloma, Papillary Meningioma and Metastatic Papillary Carcinomas. (Adapted from WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4064] "Protoplasmic Astrocytoma is a rare variant of Diffuse Astrocytoma. It is predominantly composed of neoplastic astrocytes showing a small cell body with few, flaccid processes with a low content of glial filaments and scant GFAP expression. This lesion is not well defined and is considered by some authors as an occasional histopathological feature rather than a reproducibly identifiable variant. When occurring in children, this neoplasm may be difficult to separate from Pilocytic Juvenile Astrocytoma. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4065] "Gemistocytic Astrocytoma is a rare variant of Diffuse Astrocytoma. It is characterized by the presence of a conspicuous, though variable, fraction of gemistocytic neoplastic astrocytes. Gemistocytes are round to oval astrocytes with abundant, glassy, non-fibrillary cytoplasm which appears to displace the dark, angulated nucleus to the periphery of the cell. To make the diagnosis of Gemistocytic Astrocytoma, gemistocytes should amount to more than approximately 20% of all tumor cells. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [4066] "Fibrillary Astrocytoma is the most frequent histological variant of Diffuse Astrocytoma. It is predominantly composed of fibrillary neoplastic astrocytes. Nuclear atypia is a diagnostic criterion but mitotic activity, necrosis and microvascular proliferation are absent. A single mitosis does not yet allow the diagnosis of anaplastic astrocytoma. The occasional or regional occurrence of gemistocytic neoplastic cells is compatible with the diagnosis of fibrillary astrocytoma. (WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4067] "Pleomorphic Xanthoastrocytoma is an astrocytic tumor with a relatively favorable prognosis (WHO grade II) and is typically encountered in children and young adults. It has a superficial location in the cerebral hemispheres and involvement of the meninges. Characteristic features include pleomorphic and lipidized cells expressing GFAP and often surrounded by a reticulin network as well as eosinophilic granular bodies. For lesions with significant mitotic activity (5 or more mitoses per 10 HPF) and/or with areas of necrosis, the designation \"pleomorphic xanthoastrocytoma with anaplastic features\" may be used. (WHO)"                                                                                                                                                                                                                                                                                                                                                     
 [4068] "Astroblastoma is a rare glial neoplasm more commonly found in young adults. It is characterized by tumor cells with characteristics suggestive of an astrocytic origin (positive for GFAP), arranged perivascularly. The cells have broad, non-tapering processes radiating towards a central blood vessel. The biologic behavior of astroblastomas is variable, so no WHO grade has been established, yet. (Adapted from WHO.) NCIPDQ"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4069] "A rare histological variant of Glioblastoma (WHO grade IV) with a predominance of bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin network and a high frequency of TP53 mutations. (WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4070] "A WHO grade III oligodendroglioma with focal or diffuse malignant morphologic features (prominent nuclear pleomorphism, mitoses, and increased cellularity). --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4071] "Medulloepithelioma (WHO grade IV) is a rare, highly malignant embryonal brain tumor which affects young children.  Histologically, it is characterized by papillary, tubular or trabecular arrangements of neoplastic neuroepithelium mimicking the embryonic neural tube. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4072] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4073] "A WHO grade I classic and common variant of Meningioma. The tumor cells form lobules surrounded by thin, collagenous septa. The tumor cells are largely uniform, like normal arachnoid, with oval nuclei that may show central clearing. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [4074] "A WHO grade I classic and common variant of meningioma, in which spindle-shaped cells resembling fibroblasts form parallel and interlacing bundles on a matrix with abundant collagen and reticulin. Whorl formation and psammoma bodies are infrequent. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [4075] "A WHO grade I meningioma showing many psammoma bodies that may become confluent, forming irregular calcified and occasionally, ossified masses. These tumors often occur in the thoracic spinal region, usually in middle-aged women. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4076] "A WHO grade I meningioma showing a microscopically typical meningioma background with numerous blood vessels superimposed.  The vascular channels may be small- or medium-sized, and may be thin-walled or have hyalinized, thickened walls. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [4077] "A common WHO grade I meningioma with features transitional between those of meningothelial and fibrous meningioma. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4078] "A rare condition characterized by diffuse spread of sarcoma cells throughout the meninges.  The neoplastic cells are derived from meningeal connective tissue.  Clinically, the disorder may present as a fulminant pachymeningitis and/or encephalitis.  (KEV 8-13-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4079] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4080] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4081] "An aggressive, usually diffuse non-Hodgkin's lymphoma composed of monomorphic small to medium sized B-lymphocytes (centrocytes).  Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement.  Gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin's lymphoma.  The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA.  -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4082] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4083] "A clinico-pathological entity reflecting the multiple polyps throughout the gastrointestinal tract created as a result of involvement by a non-Hodgkin's lymphoma.  Typically, mantle cell lymphomas involving the gastrointestinal tract give rise to multifocal lymphomatous polyposis.  Importantly, other histologic subtypes of non-Hodgkin's lymphoma can also produce this clinico-pathological entity.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4084] "Aggressive nodal or extranodal mature (peripheral) T-cell lymphomas that do not belong to the better defined entities of the remainder of mature T-cell lymphomas.  This category includes the lymphoepithelioid cell variant of mature T-cell lymphoma (Lennert's lymphoma) and the T-zone variant of mature T-cell lymphoma.--2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4085] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4086] "A rare extranodal B-cell non-Hodgkin's lymphoma, characterized by the presence of lymphoma cells exclusively in the lumina of small vessels, particularly capillaries.  This is an extremely aggressive lymphoma which responds poorly to chemotherapy.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [4087] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4088] "An acute myeloid leukemia characterized by bone marrow fibrosis.  The prognosis is usually poor.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4089] "Chronic myeloproliferative disorders (CMPDs) are clonal hematopoietic stem cell disorders, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, and megakaryocytic) lineages.  The proliferation is associated with relatively normal, effective maturation, resulting in increased numbers of granulocytes, red blood cells, and/or platelets in the peripheral blood.  CMPDs are primarily diseases of adults.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4090] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4091] "An astrocytoma, without designation of benign or malignant, that is found in the supratentorial region. The infratentorial location is more common in children."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [4092] "Benign growth of the cells of the pituitary gland that is not noted to secrete hormones"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4093] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4094] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4095] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4096] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4097] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4098] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4099] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4100] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4101] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4102] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4103] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4104] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4105] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4106] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4107] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4108] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4109] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4110] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4111] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4112] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4113] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4114] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4115] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4116] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4117] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4118] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4119] "Acute or chronic condition, characterized by the inability of the kidneys to adequately filter the blood substances, resulting in uremia and electrolyte imbalances.  Acute renal failure is usually associated with oliguria or anuria, hyperkalemia, and pulmonary edema.  Chronic renal failure is irreversible and requires hemodialysis.--2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4120] "Probably related to a recessive gene, this is Fanconi Syndrome, characterised by adult onset. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4121] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4122] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4123] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4124] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4125] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4126] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4127] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4128] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4129] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4130] "Abnormal secretion of adrenocorticotrophic hormone in conjunction with neoplastic growth occurring anywhere in the body. The most common associations are tumors of the bronchus (oat cell or carcinoid), thymic tumors (epithelial or carcinoid), pancreatic endocrine tumor. (DeVita et al. Cancer, p 1364. 4th edition. Lippincott)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4131] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4132] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4133] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4134] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4135] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4136] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4137] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4138] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4139] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4140] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4141] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4142] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4143] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4144] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4145] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4146] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4147] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4148] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4149] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4150] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4151] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4152] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4153] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4154] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4155] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4156] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4157] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4158] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4159] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4160] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4161] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4162] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4163] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4164] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4165] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4166] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4167] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4168] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4169] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4170] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4171] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4172] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4173] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4174] "(ko-LAN-jee-o-sar-KO-ma) A tumor of the connective tissues of the bile ducts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4175] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4176] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4177] "Stage 0 includes: (Tis, N0, M0).  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4178] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4179] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4180] "Stage 0 includes: (Tis, N0, M0).  Tis: Carcinoma in situ.  N0: No regional metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [4181] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4182] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4183] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4184] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4185] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4186] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4187] "Large cell lung carcinoma represents the least common histologic subtype of lung cancers comprising approximately 15% of all lung cancers.  The frequency is decreasing with improved classification through refined histopathological analysis of these tumors as poorly differentiated squamous cell carcinomas or adenocarcinomas.  Large cell carcinomas arise more frequently in the periphery of the lung.  The 5-year survival rate of patients with large cell carcinoma is very close to that for adenocarcinoma.  The survival rates are as follow: Stage I: 64%, Stage II 26%, Stage IIIA: 18%, Stage IIIB 15%, Stage IV: 5.9% (adapted from Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999). --2002"                                                                                                                                                                                                                                                                          
 [4188] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4189] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4190] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4191] "Abnormal growth of cells comprising the tissues of the lung/pleura without evidence of malignancy"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4192] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4193] "A malignant neoplasm of the pleura or peritoneum, arising from mesothelial cells.  Morphologically it is subdivided into fibrous, epithelial, and mixed mesothelioma.  It is associated with exposure to asbestos. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [4194] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4195] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4196] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4197] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4198] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4199] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4200] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4201] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4202] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4203] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4204] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4205] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4206] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4207] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4208] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4209] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4210] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4211] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4212] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4213] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4214] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4215] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4216] "A leiomyosarcoma affecting the hair-bearing parts of the extremities.  It is more commonly seen in males than females.  The survival rates are good, because of the superficial location. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4217] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4218] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4219] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4220] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4221] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4222] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4223] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4224] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4225] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4226] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4227] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4228] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4229] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4230] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4231] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4232] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4233] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4234] "A benign tumor composed of adipose (fatty) tissue.  The most common representative of this category is the lipoma. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [4235] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4236] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4237] "A non-metastasizing tumor arising from the breast parenchyma. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4238] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4239] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4240] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4241] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4242] "Serous cystadenoma is a serous neoplasm in which the cysts and papillae are lined by a single layer of cells without atypia, architectural complexity or invasion. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [4243] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4244] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4245] "Malignant germ cell tumors which arise in the ovaries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4246] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4247] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4248] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4249] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4250] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4251] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4252] "A superficial neoplastic process involving exclusively the vaginal squamous epithelium without extension to underlying tissue.  It is classified as low- or high-grade intraepithelial neoplasia.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [4253] "Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (preinvasive carcinoma. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4254] "Stage 0 includes: pTis, N0, M0, S0.  pTis: Intratubular germ cell neoplasia (carcinoma in situ).  N0: regional lymph node metastasis.  M0: No distant metastasis.  S0: Marker study levels within normal limits. (AJCC 6th ed) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4255] "A rare variant of conventional (clear cell) renal cell carcinoma.  It is a well-circumscribed multicystic mass without solid areas. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4256] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4257] "A tumor that is composed of large well-differentiated polygonal eosinophilic cells with a cytoplasm that is noted to be rather granular.  A characteristic central scar can often be seen on CT or MRI.  These tumors have benign histologic characteristics without necrosis or increased vascularity.  The reported tumors have varied widely in size but usually are asymptomatic even when they reach a large size.  The majority was discovered as an incidental finding.  (ed. Walsh PC, Retik AB, Vaughn ED, Wein AJ Campbell's Urology p.2287-2289 Volume 3, 7th edition Saunders 1998)"                                                                                                                                                                                                                                                                                                                                                                                                    
 [4258] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4259] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4261] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4262] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4263] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4264] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4265] "Benign and malignant neoplasms that arise from glial cells of the spinal cord.  Subtypes include ependymoma, astrocytoma (including low and high grade forms), medulloblastoma, and oligodendroglioma. (KEV 8-22-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4266] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4267] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4268] "Abnormal growth of cells that comprise the optic tract. This condition can be seen in association with Neurofibromatosis 1. It is most commonly seen in the pediatric age group."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4269] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4270] "Abnormal malignant growth of the cells that comprise cranial nerve VIII. This can lead to difficulties with hearing and balance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4272] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4273] "A benign, usually encapsulated neoplasm of the lacrimal gland composed of epithelial and mesenchymal cells.  Pleomorphic adenomas are neoplasms that develop in the salivary glands or heterotopic salivary gland tissues.  It has been suggested that myoepithelial cells play a major role in the histogenesis of these tumors.  In the lacrimal gland, pleomorphic adenomas presumably develop from metaplastic myoepithelial cells. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4274] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4276] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4277] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4278] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4279] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4280] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4281] "A malignant melanoma within the conjunctiva of the eye."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4282] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4283] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4284] "A melanoma within the cornea of the eye."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [4285] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4286] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4287] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4288] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4289] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4290] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4291] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4292] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4293] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4294] "A rare chronic myeloproliferative disorder characterized by a clonal proliferation of eosinophilic precursors resulting in persistently increased numbers of eosinophils in the blood, marrow and peripheral tissues.  Since acute eosinophilic leukemia is at best exceedingly rare, the term eosinophilic leukemia is normally used as a synonym for chronic eosinophilic leukemia.  In cases in which it is impossible to prove clonality and there is no increase in blast cells, the diagnosis of \"idiopathic hypereosinophilic syndrome\" is preferred.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                
 [4295] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4296] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4297] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4298] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4299] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4300] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4301] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4302] "Malignant neoplasms originating in the respiratory tract"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [4303] "A primary or metastatic malignant tumor involving the small intestine, large intestine, or both.  Representative examples are carcinomas, lymphomas, and sarcomas. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [4304] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4305] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4306] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4307] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4308] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4309] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4310] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4311] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4312] "The spread of the cancer to the large intestine.  This may be from a primary colon cancer, or from a cancer at a distant site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4313] "Cancer that has spread from the original (primary) tumor to the bone marrow."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [4314] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4315] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4316] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4317] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4318] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4319] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4320] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4321] "Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4322] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4323] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4324] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4325] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4326] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4327] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4328] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4329] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4330] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4331] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4332] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4333] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4334] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4335] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4336] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4337] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4338] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4339] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4340] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4341] "A benign tumor arising from the wall of the colon and rectum. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4342] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4343] "Abnormal growth, without malignant characteristics, of the cells that comprise the pancreas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [4344] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4345] "small pendulous outgrowth of the skin; in middle life, it usually occurs on the neck in pedunculatd seborrheic keratosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [4346] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4347] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4348] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4349] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4350] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4351] "A benign growth of hormone secreting tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [4352] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4353] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4354] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4355] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4356] "A malignant tumor occurring in the meninges, which surround the brain and spinal cord.  The most common are meningiomas. - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [4357] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4358] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4359] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4360] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4361] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4362] "A neuroendocrine tumor of the stomach, occurs most often in elderly females.  It may arise in a background of atrophic gastritis, usually resulting from pernicious anemia.  Gastric carcinoid tumors can be solitary or multiple, sometimes arise in individuals with the MEN-1 syndrome, and rarely metastasize.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4363] "Gastric lymphomas are either primary or metastatic.  Primary gastric lymphomas are defined as lymphomas originating from the stomach and contiguous lymph nodes.  The majority are high-grade B-cell non-Hodgkin's lymphomas, some of which have developed through progression from low-grade lymphomas of mucosa-associated lymphoid tissue.  Primary gastric lymphomas are often associated with Helicobacter Pylori infection.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4364] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4365] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4366] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4367] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4368] "Low and high grade astrocytomas which arise in the spinal cord.  Histologic types include pilocytic astrocytomas, fibrillary astrocytomas, anaplastic astrocytomas and glioblastoma multiforme.  (From Schutta, Spinal Tumors, in Clinical Neurology, Ch44, p42, 1994)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4369] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4370] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4371] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4372] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4373] "A rare, highly malignant, epithelial tumor that develops from a hydatidiform mole (50%), following abortion (25%), or during normal pregnancy (22%). Histologically, choriocarcinomas consist of invasive and anaplastic trophoblastic tissue composed of cytotrophoblastic and syncytiotrophoblastic cells, secretion of human chorionic gonadotropin, and abundant vascularity. Because of rapid growth and a high propensity for hemorrhage, this neoplasm often constitutes a medical emergency. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4374] "Benign fatty tumor involving the breast."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [4375] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4376] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4377] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4378] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4379] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4380] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4381] "An Endometrial Hyperplasia characterized by cytologic and architectural changes which may lead to Endometrial Carcinoma.  Despite the atypical features and possible course, there is debate on whether to consider this a neoplasm.  The relationship with Endometrial Intraepithelial Neoplasia is also unclear."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4382] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4383] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4384] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4385] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4386] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4387] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4388] "Primary Melanocytic Lesions are diffuse or circumscribed, benign or malignant tumors arising from melanocytes of the leptomeninges. This group includes: (1) Diffuse Melanocytosis (diffuse melanosis) and Neurocutaneous Melanosis, (2) Melanocytoma, and (3) Malignant Melanoma, but intermediate or mixed cases may occur.  (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4389] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4390] "A B-cell non-Hodgkin's lymphoma composed of small lymphocytes which surround and replace the splenic white pulp germinal centers.  This entity was previously known as a splenic lymphoma with circulating villous lymphocytes, is rare, and involves the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood.  The patients present with splenomegaly and the clinical course is indolent.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4391] "A T-cell peripheral neoplasm characterized by a persistent (>6 months) increase in the number of peripheral blood large granular lymphocytes, without a clearly identified cause. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4392] "A malignant (clonal) proliferation of immunoglobulin secreting plasma cells.  Plasma cells are of B cell origin, and are grouped under Mature B-Cell Neoplasm in the WHO classification.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4393] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4394] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4395] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4396] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4397] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4398] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4399] "An acute leukemia of ambiguous lineage characterized by blasts which co express myeloid and T or B lineage antigens or concurrent B and T lineage antigens.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4400] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4401] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4402] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4403] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4404] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4405] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4406] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4407] "Rare congenital disorder inherited as an X-linked defect characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [4408] "(DER-ma-toe-FI-bro-sar-KO-ma pro-TOO-ber-anz) A type of tumor that begins as a hard nodule and grows slowly.  These tumors are usually found in the dermis (the inner layer of the two main layers of tissue that make up the skin) of the limbs or trunk of the body.  They can grow into surrounding tissue but do not spread to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4409] "A predominantly extranodal, mature T-cell non-Hodgkin's lymphoma, characterized by an often angiocentric and angiodestructive NK/T cell infiltrate.  The qualifier \"nasal-type\" draws attention to the fact that the nasal cavity is the commonest site of involvement.  The prognosis is variable.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [4410] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4411] "A combination of opsoclonus (involuntary conjugate eye movements of large amplitude) and myoclonic jerks. This can be a paraneoplastic syndrome (a result of brain metastasis) or post-infectious (viral encephalitis)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4412] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4413] "Atypical cells within the epidermal layer of the skin that can be confused with the cells seen in Bowen's disease. These cells are large with hyperchromatic nuclei. Mitoses are frequently encountered. This condition is most commonly associated with the breast but can involve the anogenital area, axilla, esophagus, eyelid, external auditory canal. (Devita et al. Cancer. p.1588 4th edition Lippincott)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4414] "Leukocyte Adhesion Deficiency, Type I; LFA-I deficiency"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4415] "Leukocyte Adhesion Deficiency, Type II.  An inherited disease affecting the metabolism of fucose, which affects the expression of the sialyl Lewis X antigen, the fucose-containing ligand for E- and P-selectins, resulting in a deficiency in neutrophil adhesion.  SYN Sialyl-Lewis X defect."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4416] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4417] "A disorder, wherein unstable chromosomes have a tendency to break and become rearranged, characterized by microcephaly, stunted growth, subnormal mental development, cafe-au-lait spots, and immunodeficiency. The syndrome is named after the University of Nijmegen in the Netherlands. (JABL99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4418] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4419] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4420] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4421] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4422] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4423] "Sexual climax without the release of semen from the penis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [4424] "A rare cancer in women of childbearing age in which cancer cells grow in the tissues that are formed in the uterus after conception. Also called gestational trophoblastic disease, gestational trophoblastic neoplasia, molar pregnancy, or choriocarcinoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4425] "An intermediate cutaneous fibrohistiocytic neoplasm typically affecting young patients, characterized by painless nodules in the dermis or subcutaneous tissues.  This tumor can recur, but metastases have not been reported. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4426] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4427] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4428] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4429] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4430] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4431] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4432] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4433] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4434] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4435] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4436] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4437] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4438] "Cellular Ependymoma is a variant of Ependymoma which shows conspicuous cellularity without a significant increase in mitotic rate. (Adapted from WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4439] "Clear Cell Ependymoma is a variant of Ependymoma which shows an oligodendroglia-like appearance with a clear perinuclear halo.  It is often located in the supratentorial compartment of young patients. Differential diagnoses include Oligodendroglioma, Central Neurocytoma, Clear Cell Carcinoma and Hemangioblastoma. (Adapted from WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4440] "Choroid Plexus Carcinoma (WHO grade III) is a malignant Choroid Plexus Tumor which shows anaplastic features and usually invades neighboring brain structures. CSF metastases are frequent. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [4441] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4442] "Anaplastic Ganglioglioma (WHO grade III) is a neuroepithelial neoplasm composed of neoplastic, mature ganglion cells and anaplastic glial cells. These anaplastic changes in the glial component and high MIB-1 and TP53 labelling indices may indicate aggressive behavior.  However, the correlation of histological anaplasia with clinical outcome is inconsistent. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4443] "A WHO grade I meningioma characterized by the presence of pseudo-psammoma bodies: focal epithelial differentiation, in the form of intracellular lumina containing PAS-positive, eosinophilic material. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4444] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4445] "A WHO grade I meningioma characterized by extensive chronic inflammatory infiltrates with the meningothelial component in the background. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [4446] "A WHO grade I meningioma characterized by cells with elongated processes and by a loose, mucinous background, giving the appearance of many small cysts. There may be many pleomorphic cells. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4447] "A WHO grade II meningioma that is often patternless and is composed of polygonal cells with a clear, glycogen-rich cytoplasm. Some of these tumors, particularly if intracranial, may be associated with a more aggressive behavior. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4448] "A WHO grade II meningioma with increased mitotic activity or three or more of the following features: increased cellularity, small cells with high nuclear to cytoplasm ratio, prominent nucleoli, uninterrupted patternless or sheet-like growth, and foci of spontaneous or geographic necrosis. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4449] "Cellular Schwannoma (also called Cellular Neurilemmoma or Cellular Neurinoma) is a hypercellular Schwannoma composed exclusively or predominantly of Antoni A tissue, and devoid of Verocay bodies. Cellular Schwannomas are benign, although recurrences can occur, especially when located in the spine. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4450] "Papillary Craniopharyngioma is composed of sheets of squamous epithelium which separate to form pseudopapillae. This variant typically lacks nuclear palisading, wet keratin, calcification, and cholesterol deposits. Clinically, endocrine deficiencies are more often associated with Papillary Craniopharyngioma than with the Adamantinomatous type. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4451] "Adamantinomatous Craniopharyngioma consists of broad strands, cords and bridges of a multistratified squamous epithelium with peripheral palisading of nuclei. Diagnostic features include nodules of compact 'wet' keratin and dystrophic calcification. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4452] "Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) or clonal (malignant) proliferation of lymphoid cells that develops as a consequence of immunosuppression in a recipient of a solid organ or bone marrow allograft.  PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven polyclonal lymphoid proliferations to EBV-positive or EBV- negative lymphomas of predominantly B-cell or less often T-cell type. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4453] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4454] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4455] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4456] "A condition of the nervous system that causes numbness, tingling, burning or weakness.  It usually begins in the hands or feet, and can be caused by certain anticancer drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4457] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4458] "Peutz-Jeghers polyps occur within the stomach, small and large intestines, and rarely within esophagus, nasopharynx and the urinary tract.  The Peutz-Jeghers polyps are grossly lobulated and dark.  Microscopically, they have a central core of smooth muscle covered by mucosa.  The smooth muscle shows tree-like branching.  The question of whether or not the Peutz-Jeghers polyp is precancerous is a matter of controversy.  The loss of heterozygosity on chromosome 19p (where the responsible gene LKB1 is located) suggests that the increased risk of malignancy may be due to malignant transformation from hamartoma to adenocarcinoma. --2002"                                                                                                                                                                                                                                                                                                                                    
 [4459] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4460] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4461] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4462] "A mature T-cell non-Hodgkin's lymphoma, also known as intestinal T-cell lymphoma.  This disease is uncommon in most parts of the world, but is seen with increasing frequency in those areas with a high prevalence of celiac disease.  The prognosis is poor.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4463] "A WHO grade I large cystic tumor that occurs almost exclusively in infants, with a prominent desmoplastic stroma having a neuroepithelial population of neoplastic astrocytes together with a variable neuronal component. They involve the superficial cerebral cortex and leptomeninges, and often attach to the dura. Although clinically they present as large tumors, they generally have a good prognosis following surgical resection. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4464] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4465] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4466] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4467] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4468] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4469] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4470] "A Brenner tumor in which the cellular population is cytologically benign and there is no stromal invasion present. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [4471] "Neuronal and Mixed Neuronal-Glial Tumors have in common a variable amount of neuronal and, less consistently, glial differentiation. They occur at a low frequency and usually carry a favorable prognosis. They include: Gangliocytoma, Ganglioglioma, Dysembryoplastic Neuroepithelial Tumor, Central Neurocytoma, Cerebellar Liponeurocytoma and Paraganglioma. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4472] "Melanotic MPNST is a rare variant of Malignant Peripheral Nerve Sheath Tumor (MPNST)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4473] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4474] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4475] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4476] "An aggressive T-cell leukemia, characterized by the proliferation of small to medium sized prolymphocytes with a mature T-cell phenotype, involving the blood, bone marrow, lymph nodes, liver, spleen, and skin.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4477] "A malignant B-cell lymphoproliferative process affecting the blood, bone marrow, and spleen.  The B-prolymphocytes are medium-sized, round lymphoid cells with prominent nucleoli.  The B-prolymphocytes must exceed 55% of lymphoid cells in the blood.  Cases of transformed chronic lymphocytic leukemia (CLL) and CLL with increased prolymphocytes are excluded.  The prognosis is poor.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4478] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4479] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4480] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4481] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4482] "A malignant neoplasm that has spread to the liver from another (primary) anatomic site.  Such malignant neoplasms may be carcinomas (e.g. breast, colon), lymphomas, melanomas, or sarcomas. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4483] "Any closed cavity or sac, normal or abnormal, lined by epithelium, and especially one that contains a liquid or semisolid material. (Dorland, 27th ed). This concept refers specifically to a cyst formed within the oral cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4484] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4485] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4486] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4487] "Clinical esophageal segment composed of skeletal muscle.  It corresponds to the superior part of the upper third topographic segment of the esophagus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4488] "Clinical esophageal segment composed of smooth muscle.  It corresponds to the inferior part of the lower third topographic segment of the esophagus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4489] "Malignant neoplasm originating in the middle ear."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4490] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4491] "A primary or metastatic tumor involving the structures of the eye (conjunctiva, cornea, uvea, retina), the lacrimal gland, and the orbit.  Representative examples are melanoma, carcinoma, lymphoma, and retinoblastoma. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4492] "Abnormal malignant growth of the cells that comprise cranial nerve I. This can lead to difficulties with the sense of smell. Since taste and smell are intimately linked in terms of the enjoyment of food, a deficiency in the ability to smell can lead to decreased food intake with possible malnutrition."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4493] "Malignant growth of cells of the pituitary gland, without specification of whether the cells are hormone secreting or not. Pituitary carcinomas are noted to be extremely rare."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [4494] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4495] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4496] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4497] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4498] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4499] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4500] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4501] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4502] "Abnormal growth of the tissue of the kidney without malignant elements. The most common of these lesions is the renal cyst, comprising approximately 70% of benign renal lesions. (ed. Walsh PC, Retik AB, Vaughn ED, Wein AJ. Campbell's Urology, p.2285 Volume 3, 7th edition WB Saunders)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [4503] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4504] "Abnormal growth of the cells of the eye including but not limited to choroid, ciliary body, retina, sclera that is determined to be benign"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [4505] "Primary neoplasms of the brain which are noninvasive and tend to grow slowly.  They are generally classified by location and histologic type.  In children, astrocytomas of the cerebellum represent relatively common benign brain neoplasms.  In adult meningiomas, neurilemomas and pituitary tumors comprise the majority of benign tumors.  (KEV 8-14-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4506] "Abnormal growth of cells in the pituitary gland without evidence of malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4507] "An epithelial tumor arising from the ovary without definitive morphologic characteristics of malignancy.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4508] "A neoplasm of the heart and/or blood vessels without specification as to whether it is benign or malignant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4509] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4510] "loss of intellectual functions such as memory, learning, reasoning, problem solving, and abstract thinking while vegetative functions remain intact."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4511] "Benign neoplasms of the gastrointestinal tract, which includes the oral cavity, pharynx, esophagus, stomach, intestines, rectus and anus and other structures involved with digestion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4512] "Abnormal growth of the cells that comprise the tissues of the central or peripheral nervous system, without specification as to whether the growth is benign or malignant in nature."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4513] "Abnormal growth of cells in the nervous system without evidence of malignant characteristics. Unlike other organ systems, tumors in the central nervous system can have benign histological characteristics but still have life threatening effects due to their location within the neuraxis e.g. brainstem gliomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4514] "Abnormal growth of muscle in the left atrium which may cause obstruction to the outflow tract at that location"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4515] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4516] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4517] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4518] "This is a non-cancerous growth found in the prostate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4519] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4521] "The reemergence of neoplasm after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4522] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4523] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4524] "Benign and malignant neoplasms which arise from or metastasize to the optic or second cranial nerve which extends from the optic disc of the eye and joins the optic chiasm.  Clinical features may include visual loss, proptosis, and local pain.  The majority of optic nerve tumors or optic gliomas. (KEV 8-8-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4525] "A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4526] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4527] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4529] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4531] "Symptoms and conditions which are the result of treatment but arise months or years after the therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4532] "Cancer cells that remain after attempts to remove the cancer have been made."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [4533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4534] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4535] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4536] "A malignant tumor which reappears in an individual following a remission. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4537] "A carcinoma of the thyroid gland.  It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [4538] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4539] "(YOO-ingz sar-KO-ma) A type of bone cancer that usually forms in the middle (shaft) of large bones. Also called Ewing's sarcoma/primitive neuroectodermal tumor (PNET)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4540] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4541] "A carcinoma arising from the squamous cells of the epidermis.  Skin squamous cell carcinoma is most commonly found on sun-exposed areas.  The majority of the tumors are well-differentiated. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4542] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4543] "A malignant tumor of neuroglial tissue. This term may be used to describe one of a number of primary neoplasms of the brain and spinal cord, including astrocytomas, ependymomas, neurocytomas, etc. Malignant gliomas are the most common primary tumors of the brain. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4544] "Central Neurocytoma is an intraventricular neuronal neoplasm composed of uniform round cells with neuronal differentiation. It is typically located in the lateral ventricles in the region of the foramen of Monro.  It generally affects young adults and has a favorable prognosis. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [4545] "A malignant tumor arising from the epithelium that covers the tongue.  The vast majority of tongue carcinomas are moderately or poorly differentiated squamous cell carcinomas. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4546] "A primary or metastatic carcinoma of the tonsil. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4547] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4548] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4549] "recurrent or persistant obstructive jaundice, frequently with ulcerative colitis, due to extensive obliterative fibrosis of the bile ducts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4550] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4551] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4552] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4553] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4554] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4555] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4556] "A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation.  It represents one of the two ends of the spectrum called Ewing's sarcoma/peripheral neuroectodermal tumor.  It often affects the diaphysis or metaphyseal-diaphyseal portion of long bones.  Clinical findings include pain and a mass in the involved area.  Fever, anemia, leucocytosis, and an increased sedimentation rate are often seen.  X-ray examination reveals osteolytic lesions.  The prognosis depends on the stage, anatomic location, and size of the tumor. -- 2003"                                                                                                                                                                                                                                                                                                                                                                  
 [4557] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4558] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4559] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4560] "A lesion that is characterized by architectural and cytologic abnormalities of the esophageal epithelium, and carries a predisposition for progression to invasive carcinoma.  Intraepithelial neoplasia (dysplasia) of the esophagus is graded as low or high grade.  In this two-tier system, severe dysplasia and carcinoma in situ are included under the rubric of high grade intraepithelial neoplasia and may have the same clinical implications.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4561] "A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal epithelium.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4562] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4563] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4564] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4565] "Pancreatic intraepithelial neoplasia (PanIN) is a recently adopted term to describe precancerous pancreatic duct lesions. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4566] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4568] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4569] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4570] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4571] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4572] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4573] "Stage 0 includes: (Tis, N0, M0).  Tis: Carcinoma in situ: intraepithelial or invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.)-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4574] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4575] "Laryngeal carcinoma is a carcinoma that arises from the laryngeal epithelium.  More than 90% of laryngeal carcinomas are squamous cell carcinomas.  The remainder are adenoid cystic carcinomas, mucoepidermoid carcinomas and carcinomas with neuroendocrine differentiation. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4576] "any new and abnormal growth of the inner part of the adrenal gland; specifically a new growth of tissue of the inner part of the adrenal gland in which the growth is uncontrolled and progressive."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4577] "A neoplasm involving the cells of the placenta"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4578] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4579] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4580] "A leukemia characterised by the presence of atypical monocytes in the bone marrow and the peripheral blood. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4581] "Sex cord-stromal tumors comprise about 5% of all ovarian neoplasms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4582] "Prostate carcinoma is one of the most common malignant tumors afflicting men.  The majority of carcinomas arise in the peripheral zone and a minority occur in the central or the transitional zone of the prostate gland.  Grossly, prostatic carcinomas appear as ill-defined yellow areas of discoloration in the prostate gland lobes.  Adenocarcinomas represent the overwhelming majority of prostatic carcinomas.  Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic carcinoma.  Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy.  Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease.  -- 2002"                                                                                                                                                                                                             
 [4583] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4584] "Cancer of the vulva (the external female genital organs, including the clitoris, vaginal lips, and the opening to the vagina)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4585] "Abnormal growth of the cells comprising the soft tissue, excluding metastatic tumors that arise in the soft tissue. This concept specifically refers to tumors with malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4586] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4587] "A tumor in the part of the brain that connects to the spinal cord (the brain stem)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4588] "The disappearance of all signs of cancer in response to treatment.  This does not always mean the cancer has been cured."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [4589] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4590] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4591] "A rare or \"orphan\" disease affects fewer than 200,000 people in the United States. There are more than 5,000 rare disorders that, taken together, affect approximately 20 million Americans. One in every 12 individuals in this country has received a diagnosis of a rare disease. (from National Organization for Rare Disorders"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4592] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4593] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4594] "An indication that a person has a condition or disease.  Some examples of symptoms are headache, fever, fatigue, nausea, vomiting, and pain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [4595] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4596] "A carcinoma originating in the lung.  Lung carcinomas usually arise from the epithelium that lines the bronchial tree (bronchogenic carcinomas), and are classified as small cell or non-small cell carcinomas.  Non-small cell lung carcinomas are usually adenocarcinomas, squamous cell carcinomas, or large cell carcinomas.  Metastatic carcinomas to the lung are also common, and can be difficult to distinguish from primary tumors. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4597] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4598] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4599] "The spread of the cancer to the spine.  This may be from a primary spinal cancer, or from a cancer at a distant site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4600] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4601] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4602] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4603] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4604] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4605] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4607] "A primary or metastatic malignant tumor involving any part of the gastrointestinal tract. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4608] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4609] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4610] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4611] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4612] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4613] "History of leukemia after therapy with no evidence on the peripheral blood or bone marrow of leukemia (normalization of all hematologic parameters)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4614] "Acute leukaemia not growing; responding to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4615] "Leukemia that is no longer growing or metastasizing; it is responding to therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4616] "Granulocytic leukemia, remission.  1. Abatement or lessening in severity of the symptoms of a disease. 2. The period during which such abatement occurs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [4617] "Monocytic leukaemia responding to treatment and not proliferating"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4618] "The abatement of lymphoid leukaemia, response to therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [4619] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4620] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4621] "The spread of the cancer to and establishment in the lymph nodes"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4622] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4623] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4624] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4625] "(ep-ih-THEE-lee-ul) Cancer that occurs in the cells lining the ovaries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4626] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4627] "A disease in which malignant (cancer) cells are found in the tissues of the colon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4628] "Gastric carcinoma is a malignant epithelial tumor of the stomach mucosa.  The vast majority of gastric carcinomas are adenocarcinomas, arising from the gastric glandular epithelium. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [4629] "Bladder carcinoma is a carcinoma arising from the bladder epithelium.  Approximately 90% of the bladder carcinomas are transitional cell carcinomas.  The remainder are squamous cell carcinomas, adenocarcinomas and small cell neuroendocrine carcinomas. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4630] "(guy-neh-ko-LAH-jik) Cancer of the female reproductive tract, including the cervix, endometrium, fallopian tubes, ovaries, uterus, and vagina."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4631] "Skin cancer that arises in basal cells or squamous cells but not in melanocytes (pigment-producing cells of the skin)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4632] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4633] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4634] "A type of lung cancer in which the cells appear small and round when viewed under the microscope. Also called oat cell lung cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4635] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4636] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4637] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4638] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4639] "A condition marked by small sacs or pouches (diverticula) in the walls of an organ such as the stomach or colon. These sacs can become inflamed and cause a condition called diverticulitis, which may be a risk factor for certain types of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4640] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4641] "A hereditary condition characterized by sparse and brittle hair, short stature, and mental retardation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4642] "Malignant growth of the germ cells in testicular tissue (from PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4643] "Malignant neoplasms of fibrous histiocytoma that have metastasized to a secondary site"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4644] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4645] "NIH: Respiratory distress of any etiology, excluding neonatal respiratory distress syndrome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [4646] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4647] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4648] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4649] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4650] "Abnormal growth of the cells that comprise the organs of the female reproductive tract. This concept refers to growths without malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [4651] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4652] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4653] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4654] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4655] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4656] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4657] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4658] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4659] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4660] "A variety of neoplasms arising from the skull base may affect the CNS, mainly by expansion, causing optic nerve and hypothalamic symptoms. Most frequent are pituitary adenomas, which are traditionally not grouped together with CNS tumors. Other, less frequent lesions in this region include granular cell tumors of the pituitary stalk and chordomas. Craniopharyngiomas area also included in this group. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4661] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4662] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4663] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4664] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4665] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4666] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4667] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4668] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4669] "Benign and malignant neoplasms that arise from or metastasize to structures within the cranium.  This includes meningeal and other tumors that occur in the spaces that surround the brain, and neoplasms of the brain.  (KEV 8-9-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4670] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4671] "Non-malignant neoplasms that arise from cerebellar tissue.  During childhood the most common form is pilocytic astrocytoma although fibrillary astrocytomas may also occur.  These tumors may present with slowly progressive signs caused by a slowly expanding mass lesion or acutely due to hemorrhage of a vascular tumor.  Clinical signs and symptoms may include ataxia, nystagmus, spasticity long tract signs, headache, nausea, vomiting, papilledema, diplopia, spasticity, and weakness, etc.) (KEV 8-7-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4672] "Desmoplastic Medulloblastoma is a variant of Medulloblastoma. Some histologic features of this lesion include nodular, reticulin-free zones ('pale islands') surrounded by densely packed, highly proliferative cells that produce a dense intercellular reticulin fiber network. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4673] "A benign tumor occurring in the meninges, which surround the brain and spinal cord.  The most common are meningiomas. - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [4674] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4675] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4676] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4677] "Malignant growth of cells in the peripheral nervous system (PNS)or Autonomic Nervous System (ANS), without specification as to location"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4678] "Primary or metastatic malignant neoplasm involving the thymus. This category includes malignant thymomas as well as metastatic carcinomas from other anatomic sites. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4679] "Primary neoplasms of the brain which occur above the cerebellar tentorium.  These tumors are noninvasive and tend to grow slowly.  In children, craniopharyngiomas are relatively common.  Fairly frequent adult supratentorial benign tumors include meningiomas and pituitary adenomas.  (KEV 8-14-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [4680] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4681] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4682] "Malignant neoplasms which arise or occur within the intracranial cavity below the tentorium cerebelli.  This includes neoplasms within the brain and/or surrounding spaces."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4683] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4684] "A late complication of cancer therapy, possibly related to treatment modality or to an inherent genetic susceptibility such as mutation in p53. Much of the current data has been derived from patients treated in childhood and/or patients treated for Hodgkins lymphoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4685] "The development of a malignant neoplasm in response to medical or surgical treatment, induced by the treatment itself."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4686] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4687] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4688] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4689] "Perineuriomas (WHO grade I) are rare, benign tumors composed entirely of neoplastic perineurial cells. They can occur intraneurally or as soft tissue lesions.  (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4690] "Injury in the central or peripheral nervous system. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4691] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4692] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4693] "Rathke's pouch cysts are rarely symptomatic in the first two decades of life though they may produce symptoms in the third and fourth decades of life.  When the cysts do present in the first decades of life, the symptoms are generally associated with diabetes insipidus or other conditions related to hypopituitarism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4694] "Malignant tumor of the colon or rectum. The majority are adenocarcinomas.  Loss of imprinting (LOI) of the insulin-like growth factor II (IGF2) gene is suggested to be associated with a predisposition to sporadic colorectal cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4695] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4696] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4697] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4698] "A leukemia characterised by the absence of leukemic cells in the peripheral blood. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [4699] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4700] "Having to do with the ovaries, the female reproductive glands in which the ova (eggs) are formed. The ovaries are located in the pelvis, one on each side of the uterus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [4701] "Infection of the oropharynx with, or disease caused by, Candida, especially C. albicans. This disease usually results from debilitation (as in immunosuppression and especially AIDS), physiologic change, prolonged administration of antibiotics, and iatrogenic and barrier breakage. SYN candidosis, moniliasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4702] "AIDS related research with a minimum of 20% (or $100,000) relevance to individuals with hemophilia, a sex-linked hereditary blood defect that occurs almost exclusively in males and is characterized by delayed clotting of the blood and consequent difficulty in controlling hemorrhage even after minor injuries. (FMB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4703] "AIDS related research with a minimum of 20% (or $100,000) research efforts related to the biology, pathogenesis, development of vaccines, epidemiology, pathophysiology, diagnosis and treatment of opportunistic infections associated with HIV infection. To include: Pneumocystosis, toxoplasmosis, cryptosporidiosis, candidiasis, cryptococcosis, mycobacteriosis, cytomegalovirus, papillomavirus, herpes simplex, JC virus, coccidioides, hairy leukoplakia, and HIV-related periodontal disease. (FMB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4704] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4705] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4706] "Cancers caused by exposure to carcinogens in the general environment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4707] "Malignant neoplasm secondary to occupational exposure to carcinogens. The carcinogens can be of any type: chemicals, electromagnetic fields, UV, viruses, etc. Many of these agents may also be commonly encountered outside the occupational environment (e.g., UV) but in such cases they are not coded in this category; for farmers and sailors, UV is an occupational carcinogen. Epidemiologic studies will usually clearly identify occupational carcinogens but in experimental studies or analyses of carcinogenic mechanisms, a judgment must be made as to whether the primary means of exposure is occupational and thus requires selection of SIC 28; for example, one could be exposed to benzene in various settings, but the most frequent exposure risk would be occupational. For chemicals with which you are unfamiliar, consult the Merck Index to determine whether the chemical is used in manufacturing, agriculture, or other occupational setting. (NCI)"                 
 [4708] "TNM staging: T2a/b N0 M0-T2a means tumor invades superficial muscle, T2b means tumor invades deep muscle, N0 means no regional lymph node mets, M0 means no distant mets."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [4709] "A recurrence of adenocarcinoma of the bladder after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [4710] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4711] "Nodal marginal zone B-cell lymphoma resistant to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [4712] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4713] "Stage IV NHL means disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4714] "Stage III NHL means involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4715] "Stage II NHL means involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4716] "Stage I NHL means involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4717] "High grade B-cell lymphoma Burkett-like lymphoma resistant to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [4718] "The reemergence of high grade B-cell lymphoma Burkitt-like lymphoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [4719] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4720] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [4721] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4722] "The reemergence of Burkitt's lymphoma after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4723] "Stage II adult Hodgkin's disease means the involvement of two or more lymph node regions on the superior side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph node(s) with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4724] "Stage II adult Hodgkin's disease means the involvement of two or more lymph node regions on the inferior side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph node(s) with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4725] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4726] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4727] "The reemergence of squamous cell lung cancer after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [4728] "Stage 2 includes T3,T4,N0,M0.  T3: Tumor invades through the muscularis propria into the subserosa, or into nonperitonealized pericolic or perirectal tissues.  T4: Tumor directly invades other organs or structures, and/or perforates the visceral peritoneum (PDQ)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4729] "Stage 1 includes T1,T2,N0,M0.  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria (PDQ)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [4730] "Stage 0 includes Tis,N0,M0.  Tis: Carcinoma in situ: intraepithelial or invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4731] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4732] "Stage IV includes: IV: (Any T, Any N, M1); IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b).  M1: Distant metastasis.  Tumors of the lower thoracic esophagus.  M1a: Metastasis in celiac lymph nodes.  M1b: Other distant metastasis.  Tumors of the mid-thoracic esophagus: M1a: Not applicable.  M1b: Nonregional lymph nodes and/or other distant metastasis.  Tumors of the upper thoracic esophagus.  M1a: Metastasis in cervical nodes.  M1b: Other distant metastasis (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4733] "Stage III includes: (T3, N1, M0); (T4, Any N, M0). T4: Tumor invades adjacent structures.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [4734] "Stage II includes: IIA: (T2, N0, M0); (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0).  T1: Tumor invades lamina propria or subucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades adventitia.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4735] "Stage I includes: T1, N0, M0.  T1: Tumor invades lamina propria or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4736] "Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [4737] "A usually slow-growing neuroendocrine tumor affecting the prostate gland. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4738] "The reemergence of angiocentric lymphoma after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4739] "A classification of testicular cancers that arise in specialized sex cells called germ cells. Nonseminomas include embryonal carcinoma, teratoma, choriocarcinoma, and yolk sac tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4740] "A papilloma virus related epithelial overgrowth. It can be located anywhere on the body though when it involves the perineal region it is generally referred to as condyloma acuminata."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4741] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4742] "Patient complaints, physical findings, laboratory findings referable to the endocrinologic system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4743] "Abnormal functioning of the small and/or large intestine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [4744] "Patient complaints (symptoms), physical or laboratory findings (signs) related to the genitourinary system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [4745] "Patient complaints (symptoms), physical and/or laboratory findings related to the skin or integument."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4746] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4747] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4748] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4749] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4750] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4751] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4752] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4753] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4754] "Anal cancer secondary to AIDS"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4755] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4756] "Abnormal growth of the cells of the cervix with malignant characteristics. This concept specifically refers to this type of cancer in patients with acquired immunodeficiency syndrome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4757] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4758] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4759] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4760] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4761] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4762] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4763] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4764] "Papilloma's are benign epithelial neoplasms that produce visible warty projections from epithelial surfaces.  Papilloma's of the urethra typically occur just within or on the external meatus. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4765] "A debilitating tiredness or total lack of energy, often reported as the most common symptom in individuals with cancer.  Cancer fatigue can result from chemotherapy, radiation therapy, surgery, and other treatments; chemotherapy-induced anemia is a very frequent cause. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4766] "A fatty tumor within the bronchi"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4767] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4768] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4769] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4770] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4771] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4772] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4773] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4774] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4775] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4776] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4777] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4778] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4779] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4780] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4781] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4782] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4783] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4784] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4785] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4786] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4787] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [4788] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4789] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4790] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4791] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4792] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4793] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4794] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4795] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4796] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4797] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4798] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4799] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4800] "A malignant, clinically aggressive astrocytic tumor (glioma) localized in the brain stem. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [4801] "Abnormal growth of the infratentorial ependymal cells. This is the rarest form of brainstem tumor. The brainstem glioma/glioblastoma is more common."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4802] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4803] "A rare benign tumor which can resemble uterine fibroids (leiomyomata) found in the periphery of the kidney. They are rarely symptomatic. Biopsy may be needed to distinguish them from more malignant neoplasms. (ed. Walsh PC Retik AB, Vaughan ED, Wein AJ Campbell's Urology Volume 3, p.2291 7th edition Saunders)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4804] "A rare benign tumor which may originate from renal parenchymal fat or fat cells within the renal capsule itself. There is a female predominance. Hematuria and pain have been reported as presenting symptoms.  (ed. Walsh PC Retik AB, Vaughan ED, Wein AJ Campbell's Urology Volume 3, p.2291 7th edition Saunders)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4805] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4806] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4807] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4808] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4809] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4810] "Kidney dysfunction resulting from complications of bone marrow transplantation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [4811] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4812] "Benign and malignant neoplasms which arise from or directly involve the central or peripheral elements of the autonomic nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [4813] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4814] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4815] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4816] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4817] "(shwah-NO-ma)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4818] "Benign and malignant neoplasms arising from one or more of the cervical, thoracic, lumbar, sacral, or coccygeal nerve roots.  The majority of these tumors are benign.  Clinical manifestations may include pain, weakness and loss of sensation along the course of the involved nerve root.  Large tumors may cause spinal cord compression.  (KEV 8-8-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [4819] "Benign and malignant neoplasms which arise from the eighth cranial nerve, also referred to as the vestibulocochlear nerve. Clinical features may include hearing loss, vertigo, tinnitus, headache and involvement of the trigeminal or facial nerves. (KEV 8-8-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4820] "Benign and malignant neoplasms which arise from or metastasize to the olfactory or first cranial nerve.  Clinical features may include facial pain and impairments of taste or smell.  (KEV 8-8-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4821] "Benign and malignant neoplasms which arise from or metastasize to the trigeminal or fifth cranial nerve which provides sensory innervation to the face, oral cavity and sinuses and the muscles of mastication. Clinical features may include facial pain or sensory loss or weakness of jaw closure. f optic nerve tumors or optic gliomas.  Histologic types include trigeminal neuroma and plexiform neurofibromas. (KEV 8-8-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4822] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4823] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4824] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4825] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4826] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4827] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4828] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4829] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4830] "Benign and malignant neoplasms which occur in the brain, spinal cord, or meninges of adults.  Astrocytomas, meningiomas, pituitary adenomas, and neurilemomas are the most common primary tumors of the adult period.  Tumor metastases from other organs to the CNS are also more common in adults than in children. (KEV 8-13-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4831] "Benign and malignant neoplasms which occur in the brain, spinal cord, or meninges of children.  Posterior fossa astrocytomas, optic pathway gliomas, medulloblastomas, ependymomas, craniopharyngiomas, and pineal tumors are relatively common primary tumors of the CNS in children.  (KEV 8-13-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4832] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4833] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4834] "Neoplasms that occur within the spinal canal in the space between the spinal cord and the dura mater.  The majority of neoplasms in this location are meningiomas or neurofibromas, although neurofibromas, sarcomas, dermoid tumors, ganglioneuromas, hemangiopericytomas, paragangliomas, osteochondromas, lipomas and other neoplasms may also occur in this location.  These tumors may present with local and radicular pain, weakness and/or spinal cord compression.  (From Schutta, Spinal Tumors, in Clinical Neurology, Ch44, pp3-4, 1994)"                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4835] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4836] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4837] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4838] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4839] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4840] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4841] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4842] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4843] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4844] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4845] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4846] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4847] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4848] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4849] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4850] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4851] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4852] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4853] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4854] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4855] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4856] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4857] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4858] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4859] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4860] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4861] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4862] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4863] "A carcinoma of the breast characterized by pools of mucin and islands of malignant squamous cells.  Mucoepidermoid carcinomas of the breast are extremely rare. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [4864] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4865] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4866] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4867] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4868] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4869] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4870] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4871] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4872] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4873] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4874] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4875] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4876] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4877] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4878] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4879] "Hereditary disorder transmitted by autosomal dominant genes (EXT1-3) and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones.  The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence.  The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4880] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4881] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4882] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4884] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4885] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4886] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4887] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4888] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4889] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4891] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4892] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4893] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4894] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4895] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4896] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4897] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4898] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4899] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4900] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4901] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4902] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4903] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4906] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4907] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4910] "Stage IA includes: T1a, N0, M0.  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [4911] "Stage IB includes: T1b, N0, M0. T1b: Tumor limited to both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [4912] "Stage IC includes: T1c, N0, M0. T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarain surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [4913] "Stage IIA includes: T2a, N0, M0.  T2a: Extension and/or implants on uterus and/or tube(s). No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [4914] "Stage IIB includes: T2b N0, M0.  T2b: Extension and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [4915] "Stage IIC includes: T2c N0, M0. Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washing.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4916] "Borderline ovarian serous neoplasm is a serous neoplasm showing some or all of the features associated with carcinoma but lacking definite stromal invasion. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [4917] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4918] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4919] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4920] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4922] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4923] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4924] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4927] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4928] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4929] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4930] "Ovarian mucinous neoplasms are less common than the serous neoplasms and are bilateral in only 10% to 20% of the cases.As with their serous counterpart, they can be divided into benign (mucinous cystadenoma), borderline and malignant (mucinous adenocarcinoma and mucinous cystadenocarcinoma).  Grossly, they tend to grow larger than the serous types and are partially or completely cystic, often multiloculated.  A mucoid material is present in the lumen. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [4931] "Ovarian mucinous adenocarcinoma is a mucinous neoplasm characterized by cell atypia, increased layering of cells, greater complexity of glands and papillae (budding, bridging, appearance of solid foci) and areas of stromal invasion. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [4932] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4933] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4934] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4935] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4936] "A variant of gastric adenocarcinoma with more than half of the tumor containing extracellular mucinous pools. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [4937] "A variant of gastric adenocarcinoma characterized by malignant cells containing intracytoplasmic mucin.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4938] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4939] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4940] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4941] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4942] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4943] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4944] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4945] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4946] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4948] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4949] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4950] "A low grade, indolent B-cell lymphoma, usually associated with Helicobacter Pylori infection.  Morphologically it is characterized by a dense mucosal atypical lymphocytic (centrocyte-like cell) infiltrate with often prominent lymphoepithelial lesions and plasmacytic differentiation.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [4951] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4952] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4953] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4954] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4955] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4956] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4957] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4958] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4960] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4961] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4963] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4965] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4966] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4968] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4969] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4970] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4971] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4972] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4973] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4974] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4975] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4976] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4977] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4979] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4980] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4981] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4982] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4984] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4985] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4986] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4988] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4991] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4993] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4994] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4995] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4998] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [4999] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5001] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5002] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5004] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5005] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5007] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5008] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5009] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5010] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5011] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5012] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5013] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5014] "In medicine, a pain relief method that takes the patient's attention away from the pain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [5015] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5016] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5017] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5018] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5019] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5020] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5021] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5022] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5023] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5024] "An infrequent esophageal carcinoma arising from esophageal glands.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [5025] "A rare carcinoma of the esophagus which contains squamous cells, mucus secreting cells, and cells of an intermediate type.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [5026] "A rare benign tumor located in the distal third of the esophagus.  Histologically, cores of fibrovascular tissue are covered by mature stratified squamous epithelium.  Malignant progression to squamous cell carcinoma is extremely rare. (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [5027] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5028] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5029] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5030] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5031] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5032] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5033] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5034] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5035] "Hemangioma is a very common benign tumor.  However, vascular tumors of the breast are rare.  Hemangioma's most frequently occur in the pediatric population.  This tumor is composed of newly formed blood vessels.  Types of hemangiomas include: capillary and cavernous.  This specific concept refers to this tumor occuring in the breast. - 2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [5036] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5037] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5038] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5039] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5040] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5041] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5042] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5043] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5044] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5045] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5046] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5047] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5048] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5049] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5050] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5051] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5052] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5053] "A leiomyosarcoma predominantly affecting females, often presenting with ascites and leg edema. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [5054] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5055] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5056] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5057] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5058] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5059] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5060] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5061] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5062] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5063] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5064] "The reemergence of angiosarcoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [5065] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5066] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5067] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5068] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5069] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5070] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5071] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5072] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5073] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5074] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5075] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5076] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5077] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5078] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5079] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5080] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5081] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5082] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5083] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5084] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5085] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5086] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5087] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5088] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5089] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5090] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5091] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5092] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5093] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5094] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5095] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5096] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5097] "An astrocytic tumor affecting young people.  Morphologically, it is characterized by the presence of collagenous tissue surrounding neoplastic astrocytes.  In some cases the collagen is produced by the tumor cells (desmoplastic astrocytoma), whereas in others it is produced by mesenchymal cells (mixed glioma/fibroma). --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [5098] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5099] "A benign tumor derived from schwann cells of the peripheral sympathetic nervous system, including the sympathetic plexus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [5100] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5101] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5102] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5103] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5104] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5105] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5106] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5107] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5108] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5109] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5110] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5111] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5112] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5113] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5114] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5115] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5116] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5117] "Teratomas are tumors that differentiate along ectodermal, endodermal and mesodermal lines - they recapitulate somatic development from the three embryonic germ layers. There are mature and immature variants. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [5118] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5119] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5120] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5121] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5122] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5123] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5124] "Malignant neoplasms which occur in the brain, spinal cord, or meninges of children.  Brainstem gliomas, medulloblastomas, ependymomas, and certain pineal tumors are relatively common primary malignant tumors of the CNS in children.  (KEV 8-13-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [5125] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5126] "Angiosarcoma is a malignant endothelial neoplasm characterized by an atypical, multilayered or solid endothelial proliferation and a vascular architecture. Rare cases originate in brain or meninges and their differentiation vary from patently vascular tumors with anastomosing vascular channels lined by mitotically active, cytologically atypical endothelial cells, to poorly differentiated, often epithelioid, lesions in which immunohistochemical and ultrastructural studies are required for a definitive diagnosis. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [5127] "Lipoma is a benign lesion that, histologically, resembles normal adipose tissue. Epidural lipomas tend to be delicately encapsulated and discrete, while intradural tumors are often intimately attached to the leptomeninges and CNS parenchyma. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [5128] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5129] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5130] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5131] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5132] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5133] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5134] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5135] "Germ Cell Tumors of the CNS constitute a unique class of rare tumors that affect mainly children and adolescents. Their histopathological and biological profile largely corresponds to that of homologous germ cell neoplasms arising in the gonads and in other extragonadal sites. Germ Cell Tumors of the CNS include: Germinoma, Embryonal Carcinoma, Yolk Sac Tumor (Endodermal Sinus Tumor), Choriocarcinoma, Mature Teratoma, Immature Teratoma, Teratoma with Malignant Transformation and Mixed Germ Cell Tumors. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [5136] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5137] "CNS Rhabdomyosarcomas are malignant tumors (sarcomas) derived from striated muscle. Microscopically, strap cells, which have cross striations, may be observed but most tumors consist primarily of small cells that show little or no specific differentiation. Therefore, immunohistochemistry and/or electron microscopy may be necessary for diagnosis. Rhabdomyosarcomas must be differentiated from other brain tumors that occasionally show skeletal muscle elements, such as medullomyoblastoma, gliosarcoma and gem-cell tumors. Malignant ectomesenchymoma, a mixed tumor composed of ganglion cells or neuroblasts and one or more mesenchymal elements, usually rhabdomyosarcoma, may also occur in the brain. (Adapted from WHO.)"                                                                                                                                                                                                                                                    
 [5138] "Fibrosarcoma is a rare, malignant tumor which shows interlacing bundles of spindle cells in a herringbone pattern. Fibrosarcomas are very cellular and have high mitotic activity and often necrosis. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [5139] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5140] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5141] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5142] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5143] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5144] "A variant of gastric adenocarcinoma with exophytic growth and elongated finger-like processes lined by cylindrical or cuboidal cells supported by fibrovascular connective tissue cores.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [5145] "A variant of gastric adenocarcinoma characterized by prominent dilated or slit-like tubules. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [5146] "A carcinoma that combines an adenocarcinoma and squamous cell carcinoma.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [5147] "A rare carcinoma of the stomach resembling squamous cell carcinomas arising elsewhere in the body.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [5148] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5149] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5150] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5151] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5152] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5153] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5154] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5155] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5156] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5157] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5158] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5159] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5160] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5161] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5162] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5163] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5164] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5165] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5166] "A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract; approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [5167] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5168] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5169] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5170] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5171] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5172] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5173] "Primary tumors of the central nervous system which arise from leptomeningeal melanocytes.  These tumors may present as diffuse proliferative leptomeningeal processes (often as a component of the neurocutaneous melanosis complex) or as distinct mass lesions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [5174] "Primary Meningeal Malignant Melanomas show considerable pleomorphism, with large, and bizarre tumor cells, including multinucleated giant cells, and a variable amount of melanin pigment. High mitotic rate, necrosis, hemorrhage and invasion of brain or spinal cord parenchyma is common. Malignant Melanoma is a highly aggressive and radioresistant tumor with poor prognosis and may metastasize to remote organs. (WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5175] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5176] "A lesion which is characterized by an irregularly nodular opalescent wall which has caused it to be termed a \"pearly tumor\". The Intramural contents are soft and waxy with a variable amount of cholesterol."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [5177] "A multilobular lesion, characterized by a thick wall. The Intramural contents are soft and waxy with a variable amount of cholesterol. Teeth are rarely present though hair is not uncommon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [5178] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5179] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5180] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5181] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5182] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5183] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5184] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5185] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5186] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5187] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5188] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5189] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5190] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5191] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5192] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5193] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5194] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5195] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5196] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5197] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5198] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5199] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5200] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5201] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5202] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5203] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5204] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5205] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5206] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5207] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5208] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5209] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5210] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5211] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5212] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5213] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5214] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5215] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5216] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5217] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5218] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5219] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5220] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5221] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5222] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5223] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5224] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5225] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5226] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5227] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5228] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5229] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5230] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5231] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5232] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5233] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5234] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5235] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5236] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5237] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5238] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5239] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5240] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5241] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5242] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5243] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5244] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5245] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5246] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5247] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5248] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5249] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5250] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5251] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5252] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5253] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5254] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5255] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5256] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5257] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5258] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5259] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5261] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5262] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5263] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5264] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5265] "A slowly spreading, erythematous eczematoid plaque in the anal region.  Histologically, the basal part or whole thickness of the squamous epithelium is infiltrated by large cells with abundant pale cytoplasm and large nuclei.  Half of the cases are associated with an internal malignancy, most often a colorectal adenocarcinoma.  The other half of the cases, have a high local recurrence rate and they may become invasive.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [5266] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5267] "An adenocarcinoma arising in the anal canal epithelium, including the mucosal surface, the anal glands, and the lining of fistulous tracts.  The prognosis is related to the stage at diagnosis.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [5268] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5269] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5270] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5272] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5273] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5274] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5276] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5277] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5278] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5279] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5280] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5281] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5282] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5283] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5284] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5285] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5286] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5287] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5288] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5289] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5290] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5291] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5292] "The spread of the cancer to and establishment in the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [5293] "The spread of the cancer to the skin.  This may be from a primary skin cancer, or from a cancer at a distant site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [5294] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5295] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5296] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5297] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5298] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [5299] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5300] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5301] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5302] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5303] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5304] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5305] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5306] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5307] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5308] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5309] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5310] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5311] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5312] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5313] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5314] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5315] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5316] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5317] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5318] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5319] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5320] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5321] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5322] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5323] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5324] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5325] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5326] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5327] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5328] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5329] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5330] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5331] "A pulmonary blastoma affecting the lungs and the pleura.  Pleuropulmonary blastoma is seen in children.  Microscopically, the tumor may show features of chondrosarcoma, leiomyosarcoma, rhabdomyosarcoma, liposarcoma, or undifferentiated sarcoma.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [5332] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5333] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5334] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5335] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5336] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5337] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5338] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5339] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5340] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5341] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5342] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5343] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5344] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5345] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5346] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5347] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5348] "Primary esophageal lymphomas are infrequent.  Esophageal involvement is usually secondary from the mediastinum, lymph nodes, or a primary gastric location.  Patients are usually males, middle aged or elderly.  Dysphagia may be the presenting symptom.  Large cell lymphomas and B-cell lymphomas of the mucosa-associated lymphoid tissue are the most commonly seen morphologic variants.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [5349] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5350] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5351] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5352] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5353] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5354] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5355] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5356] "Most neuroendocrine tumors of the stomach are well differentiated, nonfunctioning enterochromaffin-like cell carcinoids arising from the oxyntic mucosa in the corpus or fundus.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [5357] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5358] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5359] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5360] "A tumor that usually presents with small nodules or small sessile polyps, predominantly in the distal esophagus.  Histologically, they are composed of sheets of oval to polygonal cells with a small central nucleus and abundant granular cytoplasm.  This is usually a benign tumor.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [5361] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5362] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5363] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5364] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5365] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5366] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5367] "A melanoma affecting the esophageal wall.  Melanoma in the esophagus is more commonly metastatic than primary.  Primary melanomas of the esophagus are polypoid and clinically aggressive.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [5368] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5369] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5370] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5371] "Cancer of the pancreas in which the cancer has spread to organs near the pancreas (stage IVA) or to organs far away from the pancreas (stage IVB)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [5372] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5373] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5374] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5375] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5376] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5377] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5378] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5379] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5380] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5381] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5382] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5383] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5384] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5385] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5386] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5387] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5388] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5389] "Stage 0: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [5390] "Cancer has spread to organs that are near the pancreas (such as the stomach, spleen, or colon) but has not spread to distant organs (such as the liver or lungs)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [5391] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5392] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5393] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5394] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5395] "Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0). T1: Tumor invades lamina propria or muscle layer.  T1a: Tumor invades lamina propria.  T1b: Tumor invades muscle layer.  N0: No regional metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [5396] "Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N0, M0); (T2, N0, M0); (T3, N0, M0).  T2: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, or pancreas, omentum or extrahepatic bile ducts. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [5397] "Stage III includes: (T4, Any N, M0).  T4: Tumor invades main portal vein or hepatic artery or invades multiple extrahepatic organs or structures. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [5398] "Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [5399] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5400] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5401] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5402] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5403] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5404] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5405] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5406] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5407] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5408] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5409] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5410] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5411] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5412] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5413] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5414] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5415] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5416] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5417] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5418] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5419] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5420] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5421] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5422] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5423] "Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0).  T1: Tumor confined to the bile duct histologically.  T2: Tumor invades beyond the wall of the bile duct.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [5424] "Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor invades the liver, gallbladder, pancreas, and/or unilateral branches or the portal vein (right or left) or hepatic artery (right or left).  N1: Regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [5425] "Stage III includes: T4, Any N, M0.  T4: Tumor invades any of the following main portal vein or its branches bilaterally, common hepatic artery, or other adjacent structures, such as the colon, stomach, duodenum, or abdominal wall.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: Distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [5426] "Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [5427] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5428] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5429] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5430] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5431] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5432] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5433] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5434] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5435] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5436] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5437] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5438] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5439] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5440] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5441] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5442] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5443] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5444] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5445] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5446] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5447] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5448] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5449] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5450] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5451] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5452] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5453] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5454] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5455] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5456] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5457] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5458] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5459] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5460] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5461] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5462] "Carcinoid tumors are rarely reported in the esophagus.  The majority of cases are males in their 5th decade.  Carcinoid tumors are typically located in the lower third of the esophagus, are of large size, and infiltrate deeply the esophageal wall.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [5463] "These neoplasms are rare in the esophagus, and include carcinoid tumor and small cell carcinoma.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [5464] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5465] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5466] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5467] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5468] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5469] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5470] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5471] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5472] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5473] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5474] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5475] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5476] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5477] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5478] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5479] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5480] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5481] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5482] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5483] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5484] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5485] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5486] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5487] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5488] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5489] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5490] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5491] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5492] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5493] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5494] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5495] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5496] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5497] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5498] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5499] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5500] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5501] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5502] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5503] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5504] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5505] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5506] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5507] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5508] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5509] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5510] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5511] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5512] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5513] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5515] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5516] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5517] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5518] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5519] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5522] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5523] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5524] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5526] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5527] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5529] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5531] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5534] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5535] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5536] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5537] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5538] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5539] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5540] "Mucoepidermoid carcinomas are the most frequent malignancy in major salivary glands, especially the parotid gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [5541] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5542] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5543] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5544] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5545] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5546] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5547] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5548] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5549] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5550] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5551] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5552] "Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [5553] "Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [5554] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5555] "Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [5556] "Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [5557] "Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. (AJCC 6th ed.) -2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [5558] "Cancer has spread to the lymph nodes around the rectum or to nearby organs such as the vagina or bladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [5559] "Cancer has spread to the lymph nodes in the middle of the abdomen or in the groin, or the cancer has spread to both nearby organs and the lymph nodes around the rectum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [5560] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5561] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5562] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5563] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5564] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5565] "A rare benign epithelial neoplasm composed of oncocytes, which are large cells with a large amount of granular eosinophilic cytoplasm containing numerous tightly-packed mitochondria.  Approximately 85% to 90% occur in the parotid gland; most of the remainder occur in the submandibular gland. The peak incidence is in the seventh through ninth decades of life. In almost all cases, swelling is the only complaint of the patient.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [5566] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5568] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5569] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5570] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5571] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5572] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5573] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5574] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5575] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5576] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5577] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5578] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5579] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5580] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5581] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5582] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5583] "A benign epithelial neoplasm with a uniform, monomorphic appearance that is dominated by basal cells forming trabecular structures. It is rare, and occurs mostly on the parotid gland. The average age of patients has been reported to be 58 years. Swelling is the most constant clinical finding. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [5584] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5585] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5586] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5587] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5588] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5589] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5590] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5591] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5592] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5593] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5594] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5595] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5596] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5597] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5598] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5599] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5600] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5601] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5602] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5603] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5604] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5605] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5607] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5608] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5609] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5610] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5611] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5612] "A benign epithelial neoplasm primarily composed of branching and interconnecting cords of single and double-cell thick rows of columnar epithelium in a very loose stroma. It often occurs in the upper lip, where only pleomorphic adenoma is more frequent. Asymptomatic swelling of the upper lip is the most common clinical finding. It may present clinically and histologically as a multifocal lesion, a feature not generally seen with other intraoral salivary gland tumors. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [5613] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5614] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5615] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5616] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5617] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5618] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5619] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5620] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5621] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5622] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5623] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5624] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5625] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5626] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5627] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5628] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5629] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5630] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5631] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5632] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5633] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5634] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5635] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5636] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5637] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5638] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5639] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5640] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5641] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5642] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5643] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5644] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5645] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5646] "Malignant neoplasm of the nasal cavity"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [5647] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5648] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5649] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5650] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5651] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5652] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5653] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5654] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5655] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5656] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5657] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5658] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5659] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5660] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5661] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5662] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5663] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5664] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5665] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5666] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5667] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5668] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5669] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5670] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5671] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5672] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5673] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5674] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5675] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5676] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5677] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5678] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5679] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5680] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5681] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5682] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5683] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5684] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5685] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5686] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5687] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5688] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5689] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5690] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5691] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5692] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5693] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5694] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5695] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5696] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5697] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5698] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5699] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5700] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5701] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5702] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5703] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5704] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5705] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5706] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5707] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5708] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5709] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5710] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5711] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5712] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5713] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5714] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5715] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5716] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5717] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5718] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5719] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5720] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5721] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5722] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5723] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5724] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5725] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5726] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5727] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5728] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5729] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5730] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5731] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5732] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5733] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5734] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5735] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5736] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5737] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5738] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5739] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5740] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5741] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5742] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5743] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5744] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5745] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5746] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5747] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5748] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5749] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5750] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5751] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5752] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5753] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5754] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5755] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5756] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5757] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5758] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5759] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5760] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5761] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5762] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5763] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5764] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5765] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5766] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5767] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5768] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5769] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5770] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5771] "A carcinoma of the renal pelvis.  The majority of renal pelvis carcinomas are transitional cell and less frequently squamous cell carcinomas.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [5772] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5773] "Stage I includes: T1, M0, M0.  T1: Tumor invades subepithelial connective tissue.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [5774] "Stage II includes: T2, N0, M0.  T2: Tumor invades muscularis.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [5775] "Stage III includes: T3, N0, M0.  T3: Tumor invades beyond muscularis into peripelvic fat or the renal parenchyma.  N0: No lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [5776] "Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into perinephric fat.  N0: No lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in single lymph node, more than 2 cm but not more than 5cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [5777] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5778] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5779] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5780] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5781] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5782] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5783] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5784] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5785] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5786] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5787] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5788] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5789] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5790] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5791] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5792] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5793] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5794] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5795] "The most common morphologic subtype of urinary bladder carcinoma (over 90% of cases).  It arises from the transitional epithelium.  It most often affects males in their sixth and seventh decades of life.  Hematuria is the most common symptom at presentation.  Pathologic stage is the strongest predictor of survival. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [5796] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5797] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5798] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5799] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5800] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5801] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5802] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5803] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5804] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5805] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5806] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5807] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5808] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5809] "Adult Wilms' tumor is morphologically identical to the childhood tumor, but is exceedingly rare."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5810] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5811] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5812] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5813] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5814] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5815] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5816] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5817] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5818] "An endophytic lesion in the urinary bladder which shares several morphologic features with urothelial papilloma.  This lesion may recur after complete excision.  Transitional cell carcinomas may arise within inverted urothelial papillomas.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [5819] "Stage 0 includes: 0a: (Ta, N0, M0) and 0is: (Tis, N0, M0).  T0: No evidence of primary tumor.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [5820] "Also known as carcinoma of the collecting ducts of Bellini, this is a rare type of renal cell carcinoma.  It arises from the collecting ducts of the renal medulla, and most authors suggest that this is an aggressive tumor. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [5821] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5822] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5823] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5824] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5825] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5826] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5827] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5828] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5829] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5830] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5831] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5832] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5833] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5834] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5835] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5836] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5837] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5838] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5839] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5840] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5841] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5842] "An abnormal growth of the cells that comprise the tissues of the brainstem. While the tumor may be histologically benign, it can produce great morbidity due to its location.  It presents most commonly in the first two decades of life."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [5843] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5844] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5845] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5846] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5847] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5848] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5849] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5850] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5851] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5852] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5853] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5854] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5855] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5856] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5857] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5858] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5859] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5860] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5861] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5862] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5863] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5864] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5865] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5866] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5867] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5868] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5869] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5870] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5871] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5872] "Stage IIIA includes: T3a, N0, M0.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor). N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [5873] "Stage IIIB includes: T3b, N0, M0.  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [5874] "Stage IIIC includes: (T3c, N0, M0); (Any T, N1, M0). T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [5875] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5876] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5877] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5878] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5879] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5880] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5881] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5882] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5884] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5885] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5886] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5887] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5888] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5889] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5891] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5892] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5893] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5894] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5895] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5896] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5897] "Tumors commonly occurring before age 18; e.g., childhood acute lymphocytic leukemia, Wilms' tumor, retinoblastoma, Hodgkin's disease, Ewing's sarcoma, rhabdomyosarcoma, Burkitt lymphoma, neuroblastoma, osteosarcoma, hepatoblastoma, cerebellar astrocytoma, medulloblastoma, craniopharyngioma, choroid plexus papilloma, brain stem glioma, optic glioma. (RAEB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [5898] "A germ cell tumor characterized by large round eosinophilic cells and focal granulomas. These tumors are found in the ovary, testes (especially undescended) anterior mediastinum and pineal gland. Placental alkaline phosphatase is a known marker of the presence of this tumor. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1766)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [5899] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5900] "Benign and malignant astrocytomas that arise from astrocytes in the cerebellum.  More than 80% of childhood cerebellar astrocytomas are pilocytic astrocytomas which have a favorable prognosis. The remainder are composed of diffuse or fibrillary subtypes with malignant astrocytomas occuring only rarely in the cerebellum during childhood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [5901] "An endometrial adenocarcinoma composed of neoplastic cells that form complex glandular patterns associated with budding and branching of the neoplastic glands.  The neoplastic glands may or may not be associated with sheet-like proliferation of malignant cells.  Endometrioid adenocarcinoma is the most commonly seen morphologic variant of endometrial adenocarcinoma. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [5902] "An endometrial carcinoma characterized by the presence of both neoplastic glandular and squamous epithelial cells. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [5903] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5906] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5907] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5910] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5911] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5912] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5913] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5914] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5915] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5916] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5917] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5918] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5919] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5920] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5922] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5923] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5924] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5927] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5928] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5929] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5932] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5933] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5934] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5935] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5936] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5937] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5938] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5939] "Stage IA includes: Tia, N0, M0.  T1a: Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension, and with stromal invasion no greater than 1mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [5940] "Stage IB includes: T1b, N0, M0.  T1ab Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension, and with stromal invasion greater than 1mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [5941] "Stage IVA includes: IVA (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4, Any N, M0).  N2: Bilateral regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [5942] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5943] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5944] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5945] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5946] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5948] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5949] "A malignant mesenchymal tumor arising from the wall of the uterine corpus (uterine body).  The most representative examples are leiomyosarcoma and endometrial stromal sarcoma. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [5950] "A rare smooth muscle neoplasm which often presents with aberrant vaginal bleeding. By the time it becomes symptomatic, a mass can be detected in the pelvis. This tumor can metastasize directly or through hematogenous and/or lymphatic routes. It has a poor prognosis, especially if it has spread outside of the uterus at the time of discovery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [5951] "A germ cell neoplasm composed of primitive epithelial cells arranged in solid, papillary, and glandular configurations.  Most patients present with a testicular mass, which may be associated with pain.  More than half of the patients have metastatic disease at diagnosis.  The form of treatment following radical orchiectomy is stage dependent. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5952] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5953] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5954] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5955] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5956] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5957] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5958] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5960] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5961] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5963] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5965] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5966] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5968] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5969] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5970] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5971] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5972] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5973] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5974] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5975] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5976] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5977] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5979] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5980] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5981] "Currently classified as a verrucous carcinoma, this is a large penile lesion with indolent clinical course, composed of well-differentiated squamous cells. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [5982] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5984] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5985] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5986] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5988] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5991] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5993] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5994] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5995] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5998] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [5999] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6001] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6002] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6004] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6005] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6007] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6008] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6009] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6010] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6011] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6012] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6013] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6014] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6015] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6016] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6017] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6018] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6019] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6020] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6021] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6022] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6023] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6024] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6025] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6026] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6027] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6028] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6029] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6030] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6031] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6032] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6033] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6034] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6035] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6036] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6037] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6038] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6039] "An inherited tendency to develop thyroid cancer and other cancers of the endocrine system. The altered gene can be detected with a blood test."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [6040] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6041] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6042] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6043] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6044] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6045] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6046] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6047] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6048] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6049] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6050] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6051] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6052] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6053] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6054] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6055] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6056] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6057] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6058] "A thymoma of any morphologic type that extends beyond the capsule and infiltrates the surrounding tissues.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [6059] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6060] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6061] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6062] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6063] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6064] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6065] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6066] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6067] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6068] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6069] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6070] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6071] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6072] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6073] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6074] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6075] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6076] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6077] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6078] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6079] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6080] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6081] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6082] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6083] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6084] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6085] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6086] "The preferred term, according to the WHO classification, is \"inflammatory myofibroblastic tumor\" or IMT.  The term \"inflammatory frbrosarcoma\" is out of favor because it is not at all clear that these are sarcomas.  Right now they are considered neoplasms indeterminate or intermediate in biologic potential."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [6087] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6088] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6089] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6090] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6091] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6092] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6093] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6094] "A benign mesenchymal neoplasm arising from fibrohistiocytic tissues.  The most common representative of this category is the benign fibrous histiocytoma. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [6095] "These fibrohistiocytic neoplasms typically affect younger patients, and are characterized by an increased risk of local recurrence and a low risk of metastasis. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [6096] "A benign fibrous histiocytoma, morphologically similar to cutaneous fibrous histiocytoma.  It occurs in the deep soft tissues and less frequently in parenchymal organs. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6097] "An intermediate cutaneous fibrohistiocytic neoplasm typically affecting young patients, presenting as a slowly growing tumor mass of the dermis and the subcutaneous tissues.  This tumor frequently recurs, and rarely metastasizes. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6098] "An intermediate fibrohistiocytic neoplasm typically affecting young patients, presenting as a slowly growing nodular or cystic tumor mass, most often in the subcutaneous tissues of the extremities.  Occasionally, patients have systemic symptoms (anemia, fever, and weight loss).  This tumor has a relatively good prognosis.  A minority of patients develop local recurrences.  Metastases are rare. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [6099] "A morphologic variant of malignant fibrous histiocytoma, characterized by a prominent storiform pattern and pleomorphic cells.  Males are affected more frequently than females.  The majority of patients present with deep large tumor masses in the extremities.  The clinical course is aggressive.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6100] "A less aggressive morphologic variant of malignant fibrous histiocytoma, characterized by extensive myxoid changes and cellular pleomorphism. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [6101] "An aggressive morphologic variant of malignant fibrous histiocytoma, characterized by the presence of occasional atypical cells which are admixed with numerous inflammatory cells.  The most common site of involvement is the retroperitoneum. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [6102] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6103] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6104] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6105] "This type of lipoma is characterized by the presence of mature adipose (fatty) tissue and islands of cells resembling lipoblasts and chondroblasts. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [6106] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6107] "Also known as superficial well differentiated liposarcoma, or lipoma-like liposarcoma, this is an intermediate lipomatous neoplasm that may recur locally.  It requires a wide local excision, but never metastasizes.  Microscopically, the adipose tissue contains large and pleomorphic lipoblasts, and is dissected by fibrous septa containing spindle cells. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [6108] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6109] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6110] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6111] "A benign or malignant myomatous neoplasm arising from smooth muscle. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [6112] "A malignant neoplasm arising from smooth muscle. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [6113] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6114] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6115] "A benign or malignant mesenchymal neoplasm arising from skeletal (striated) muscle. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [6116] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6117] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6118] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6119] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6120] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6121] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6122] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6123] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6124] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6125] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6126] "Alloimmunization is an immune response to foreign (donor) antigens."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6127] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6128] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6129] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6130] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6131] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6132] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6133] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6134] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6135] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6136] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6137] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6138] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6139] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6140] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6141] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6142] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6143] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6144] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6145] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6146] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6147] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6148] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6149] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6150] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6151] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6152] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6153] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6154] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6155] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6156] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6157] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6158] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6159] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6160] "Epithelioid MPNST is a rare variant defined as Malignant Peripheral Nerve Sheath Tumor with a predominance of epithelioid cells. They show no association with NF1. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [6161] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6162] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6163] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6164] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6165] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6166] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6167] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6168] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6169] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6170] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6171] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6172] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6173] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6174] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6175] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6176] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6177] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6178] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6179] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6180] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6181] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6182] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6183] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6184] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6185] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6186] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6187] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6188] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6189] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6190] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6191] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6192] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6193] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6194] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6195] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6196] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6197] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6198] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6199] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6200] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6201] "A common soft tissue sarcoma of childhood (peaking in the 0-5 year range and the 10 to 15 year range) usually occurring in the distal extremities. This spindle cell tumor is notable histologically for a regular interweaving of tumor and normal cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [6202] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6203] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6204] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6205] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6206] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6207] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6208] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6209] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6210] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6211] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6212] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6213] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6214] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6215] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6216] "Ewing's sarcoma which has spread from its initial site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [6217] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6218] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6219] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6220] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6221] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6222] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6223] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6224] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6225] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6226] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6227] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6228] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6229] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6230] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6231] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6232] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6233] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6234] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6235] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6236] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6237] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6238] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6239] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6240] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6241] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6242] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6243] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6244] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6245] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6246] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6247] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6248] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6249] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6250] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6251] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6252] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6253] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6254] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6255] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6256] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6257] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6258] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6259] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6261] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6262] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6263] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6264] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6265] "Cancer in the lung only and not in tissue around the lung."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [6266] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6267] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6268] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6269] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6270] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6272] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6273] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6274] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6276] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6277] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6278] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6279] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6280] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6281] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6282] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6283] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6284] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6285] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6286] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6287] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6288] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6289] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6290] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6291] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6292] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6293] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6294] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6295] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6296] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6297] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6298] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6299] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6300] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6301] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6302] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6303] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6304] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6305] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6306] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6307] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6308] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6309] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6310] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6311] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6312] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6313] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6314] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6315] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6316] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6317] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6318] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6319] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6320] "An autosomal dominant syndrome characterised by multiple colonic polyps predisposing to carcinoma of the colon, osteomas of the skull, epidermoid cysts, and fibromas.  It is associated with mutation of the APC gene. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [6321] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6322] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6323] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6324] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6325] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6326] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6327] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6328] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6329] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6330] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6331] "A small benign, probably hamartomatous, skeletal muscle lesion associated with tuberous sclerosis. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [6332] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6333] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6334] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6335] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6336] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6337] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6338] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6339] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6340] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6341] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6342] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6343] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6344] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6345] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6346] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6347] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6348] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6349] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6350] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6351] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6352] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6353] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6354] "A neuroendocrine carcinoma that occurs mainly in the sixth to seventh decade; it is as common in males as females.  It usually involves the distal half of the esophagus, and dysphagia is the presenting symptom.  The prognosis is poor.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [6355] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6356] "A malignant neuroendocrine neoplasm with aggressive clinical course, morphologically identical to the small cell carcinoma of the lung. (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [6357] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6358] "Malignant germ cell tumor within the pineal parenchyma.  This can include mixed germ cell, germinomas, teratomas, choriocarcinomas, embryonal cell carcinoma and endodermal sinus histological types.  These tumors occur more frequently in males, children and young adults.  The presenting symptoms can include hypothalamic-pituitary abnormalities with diabetes insipidus as the most common.  Malignant germ cell tumors have been noted to metastasize both within and outside the neuraxis.  One should obtain measurements of serum and CSF AFP and beta-HCG for use in diagnosis and monitoring.  A change in the levels of these tumor markers can act as a sentinel for tumor recurrence."                                                                                                                                                                                                                                                                                            
 [6359] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6360] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6361] "A type of brain tumor that usually begins in the central canal of the spinal cord. Ependymal tumors may also develop in the cells lining the ventricles of the brain, which produce and store the special fluid (cerebrospinal fluid) that protects the brain and spinal cord. Also called ependymomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [6362] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6363] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6364] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6365] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6366] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6367] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6368] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6369] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6370] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6371] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6372] "(STRO-mal) Tumors that arise in the supporting connective tissue of an organ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6373] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6374] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6375] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6376] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6377] "Abnormal secretion of parathyroid hormone in conjunction with neoplastic growth occurring anywhere in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [6378] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6379] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6380] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6381] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6382] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6383] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6384] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6385] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6386] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6387] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6388] "Also known as dermatofibroma, this is a solitary, slowly growing nodular mass, most often affecting the extremities.  It is composed of fibrous and histiocytic cells which infiltrate the dermis and occasionally the underlying subcutaneous tissue.  Usually local excision is curative.  Recurrences are reported only in a small minority of cases. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6389] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6390] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6391] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6392] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6393] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6394] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6395] "A WHO Grade 1 astrocytoma which arises in the cerebellum.  The tumor is composed of spindle shaped cells with numerous collections of reddish astrocytic fibers called Rosenthal fibers. Over 80% or the cerebellar astrocytomas of childhood are pilocytic. Pilocytic astrocytomas may rarely occur in adults. They are usually treated by surgical resection and in most cases have a favorable prognosis.  (KEV 8-7-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [6396] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6397] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6398] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6399] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6400] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6401] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6402] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6403] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6404] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6405] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6406] "Interchanges of genetic material among different chromosomes following the breaking off of pieces of chromosomes such that the total chromosome composition may still contain all of the genetic material.Balanced Chromosomal Rearrangement."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6407] "Interchanges of genetic material among different chromosomes following the breaking off of pieces of chromosomes such that the total chromosome composition does not contain all of the genetic material."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [6408] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6409] "An irregularity in the number of chromosomes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6410] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6411] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6412] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6413] "An irregularity in the number of chromosomes, usually in the form of a gain of genetic material. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [6414] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6415] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6416] "A region on a chromosome which, when stained, is uniform in appearance. (Normally, a stained chromosome shows a banding pattern.) Homogeneously staining regions contain multiple copies of a single gene.  (Online Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [6417] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6418] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6419] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6420] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6421] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6422] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6423] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6424] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6425] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6426] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6427] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6428] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6429] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6430] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6431] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6432] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6433] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6434] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6435] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6436] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6437] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6438] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6439] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6440] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6441] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6442] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6443] "An anaplastic large cell lymphoma limited to the skin at the time of diagnosis.  Most patients present with solitary or localized skin lesions, which may be tumors, nodules or papules.  The t(2;5) translocation that is present in many cases of systemic anaplastic large cell lymphoma, is not found in this disease. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [6444] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6445] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6446] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6447] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6448] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6449] "5Q minus syndrome.  A rare disorder caused by loss of part of the long arm (Q arm) of human chromosome 5. This syndrome affects myeloid (bone marrow) cells, causing treatment-resistant anemia, and myelodysplastic syndromes that may lead to acute myelogenous leukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [6450] "The cancer has spread to tissues around the larynx, such as the pharynx or the tissues in the neck. The lymph nodes in the area may contain cancer; the cancer has spread to more than one lymph node on the same side of the neck as the cancer, to lymph nodes on one or both sides of the neck, or to any lymph node that measures more than 6 centimeters (over 2 inches); or the cancer has spread to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6451] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6452] "A malignant breast neoplasm characterized by the formation of irregular, finger-like projections of fibrous stroma covered with neoplastic epithelial cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [6453] "Schneiderian papilloma most associated with malignancy.  Classically found on the lateral nasal wall with extension into the adjacent sinuses. (from J La State Med Soc 1997;149:310-5)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [6454] "Cancer has spread to distant lymph nodes within the abdomen or to organs in other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [6455] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6456] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6457] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6458] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6459] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6460] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6461] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6462] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6463] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6464] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6465] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6466] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6467] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6468] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6469] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6470] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6471] "Diffuse Melanocytosis is a diffuse or multifocal proliferation of uniform nevoid polygonal cells in the leptomeninges. Cells may spread into the Virchow-Robin spaces without frank invasion of the brain. Diffuse Melanocytosis carries a poor prognosis even in the absence of histologic malignancy. (WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6472] "Meningeal Melanomatosis is a Malignant Meningeal Melanoma with secondary diffuse meningeal spread. (WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [6473] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6474] "Usually a localized and benign fibrous neoplasm, it can sometime be malignant.  It is generally believed to be of mesothelial origin, and may or may not morphologically resemble the Solitary Fibrous Tumor found at other sites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [6475] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6476] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6477] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6478] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6479] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6480] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6481] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6482] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6483] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6484] "Tanycytic Ependymoma is a variant of Ependymoma, often found in the spinal cord, with tumor cells arranged in fascicles of variable width and cell density. Ependymal rosettes are generally absent, so this lesion must be distinguished from astrocytic neoplasms, but its EM characteristics are ependymal. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [6485] "Large Cell Medulloblastoma is a variant of Medulloblastoma (about 4% of cases). Some features of the tumor cells are large, round and/or pleomorphic nuclei with prominent nucleoli and a more abundant cytoplasm than that found in the classic medulloblastoma. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [6486] "Cerebellar Liponeurocytoma (WHO grade I or II) is a rare cerebellar neoplasm which shows advanced neuronal/neurocytic and focal lipomatous differentiation. It occurs in adults, has a low proliferative potential and has a favorable clinical prognosis. (Adapted from WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6487] "Atypical teratoid/rhabdoid tumor (WHO grade IV) is a malignant embryonal CNS tumor which occurs in children and is composed of rhabdoid cells, with or without fields resembling a classical primitive neuroectodermal tumor (PNET), epithelial tissue and neoplastic mesenchyme. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [6488] "A WHO grade I meningioma with striking focal mesenchymal differentiation. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [6489] "A WHO grade II meningioma with regions that are histologically similar to chordoma, with trabecula of eosinophilic, vacuolated cells in a myxoid background. Chordoid meningiomas have a high rate of recurrence following subtotal resection. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [6490] "An uncommon WHO grade III meningioma containing patches or extensive sheets of rhabdoid cells. Rhabdoid cells are rounded tumor cells with eccentric nuclei, often with a prominent nucleolus and prominent inclusion-like eosinophilic cytoplasm comprised of whorled intermediate filaments. Rhabdoid Meningiomas typically display an aggressive clinical course. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [6491] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6492] "Intraneural Perineuriomas (WHO grade I) are rare, benign tumors that exhibit proliferating perineural cells throughout the endoneurium, with formation of characteristic pseudo-onion bulbs. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6493] "Soft Tissue Perineuriomas (WHO grade I) are rare, benign tumors composed entirely of neoplastic perineurial cells and are unassociated with nerves. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [6494] "A subtype of classical Hodgkin's lymphoma.  Most patients present with peripheral lymphadenopathy and stage I or II disease.  The survival and progression free survival are slightly better than in other subtypes of classical Hodgkin's lymphoma. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [6495] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6496] "A non-Hodgkin's B-cell lymphoma composed of large cells, presenting as a serous effusion without detectable tumor masses.  It is universally associated with human herpes virus 8 (HHV-8)/Kaposi sarcoma herpes virus (KSHV), most often occurring in the setting of immunodeficiency.  The most common sites of involvement are the pleural, pericardial, and peritoneal cavities.  The prognosis is extremely unfavorable.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [6497] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6498] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6499] "A mature aggressive T-cell non-Hodgkin's lymphoma that preferentially infiltrates subcutaneous tissues.  Patients present with multiple subcutaneous nodules, usually in the absence of other sites of disease.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [6500] "The most frequent type of lymphoblastic lymphoma and comprises approximately 85-90% of cases.  It is more frequently seen in adolescent males.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6501] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6502] "A neoplastic proliferation of Langerhans cells with overtly malignant cytologic features.  It can be considered a higher grade variant of Langerhans cell histiocytosis (LCH) and it can present de novo or progress from antecedent LCH. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6503] "An acute leukemia of ambiguous lineage in which there is a dual population of blasts with each population expressing markers of a distinct lineage (myeloid and lymphoid or B-and T-lymphocyte).  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [6504] "An acute myeloid leukemia (AML) usually associated with monocytic features.  Patients may present with disseminated intravascular coagulation.  This AML has an intermediate survival.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [6505] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6506] "A rare malignant growth of the body of the uterus. There are multiple types, of which the most clinically relevant are the carcinosarcoma, the leiomyosarcoma, the endometrial stromal sarcoma, and the mullerian adenosarcoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [6507] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6508] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6509] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6510] "A tumor composed of at least two distinct cellular populations. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [6511] "A single focus of clonal (malignant) plasma cells either in the bone or in another anatomic site without peripheral blood involvement. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6512] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6513] "Gangliocytoma (WHO grade I) and Ganglioglioma (WHO grade I or II) are well differentiated, slow growing neuroepithelial neoplasms composed of neoplastic, mature ganglion cells either alone (gangliocytoma), or in combination with neoplastic glial cells (ganglioglioma). (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6515] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6516] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6517] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6518] "A group of noncancerous conditions that may increase the risk of developing breast cancer.  Examples include ductal hyperplasia, lobular hyperplasia, and papillomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [6519] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6522] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6523] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6524] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6526] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6527] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6529] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6531] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6533] "(as-troe-sye-TOE-ma) A tumor that begins in the brain or spinal cord in small, star-shaped cells called astrocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6534] "Anaplastic Oligoastrocytoma is an Oligoastrocytoma with histological features of malignancy, such as increased cellularity, nuclear atypia, pleomorphism, and increased mitotic activity. (WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [6535] "A rare, slow-growing tumor that begins in the oligodendrocytes (brain cells that provide support and nourishment for nerve cells).  Also called an oligodendroglioma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [6536] "Chordoid Glioma of the 3rd Ventricle is a rare, slow growing, glial tumor located in the third ventricle of adults. It is characterized histologically by clusters and cords of epithelioid, GFAP expressing tumor cells within a stroma with varying amounts of mucin, which typically contains a lymphoplasmacytic infiltrate. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [6537] "Paragangliomas are neuroendocrine neoplasms, usually encapsulated and benign, that arise in specialized neural crest cells associated with segmental or collateral autonomic ganglia (paraganglia) throughout the body. In the Central Nervous System, paragangliomas are almost always located in the cauda equina. Histologically, they consist of uniform cells with neuronal differentiation forming compact nests (zellballen), surrounded by sustentacular cells and a delicate capillary network. Paraganglioma of the Filum Terminale have a WHO grade I. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                              
 [6538] "Peripheral Neuroblastic Tumors - Neuroblastic Tumors outside the central nervous system - are clinically important neoplasms.  They display a wide range of neuronal differentiation, from highly cellular, immature round cell tumors to lesions with advanced differentiation and formation of mature ganglion cells. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [6539] "Neuroblastomas of the sympathetic nervous system and the adrenal gland are among the most frequent pediatric tumors of the nervous system. Depending on the degree and type of differentiation, three major types are recognized: Neuroblastoma (NB), Ganglioneuroblastoma (GNB), Ganglioneuroma (GN). (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [6540] "Pineal parenchymal tumors are neoplasms of the pineocyte, a cell with photosensory and neuroendocrine functions. These tumors have a wide spectrum, with tumors composed of mature elements to ones consisting of primitive, immature cells. These tumors also have differences in biological behavior and clinical outcome.  Three types are: Pineoblastoma, Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [6541] "(PIN-ee-o-sye-TOE-ma) A slow growing type of brain tumor that occurs in or around the pineal gland, a tiny organ near the center of the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [6542] "Pineal Parenchymal Tumors of Intermediate Differentiation are monomorphous tumors characterized by moderately high cellularity, mild nuclear atypia, occasional mitosis, and the absence of large pineocytomatous rosettes. They occur at all ages, from young children to adults, with a peak incidence in adulthood. Clinical behavior is variable. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [6543] "Supratentorial Primitive Neuroectodermal Tumor (PNET) (WHO grade IV) is an embryonal tumor located in the cerebrum or suprasellar region. It is composed of undifferentiated or poorly differentiated neuroepithelial cells which may display neuronal, astrocytic, ependymal, muscular or melanocytic differentiation. Cerebral neuroblastomas have distinct neuronal differentiation and Ganglioneuroblastomas have ganglion cells present. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [6544] "Plexiform Schwannoma (also called Plexiform Neurilemmoma and Plexiform Neurinoma) is a Schwannoma which grows in a plexiform or multinodular manner, presumably involving a nerve plexus. The majority arise in skin or subcutaneous tissue of an extremity, head and neck or trunk. The tumor is associated with Neurofibromatosis Type 1. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [6545] "Melanotic Schwannoma (also called Melanotic Neurilemmoma or Melanotic Neurinoma) is a rare type of Schwannoma which is circumscribed, pigmented and composed of cells with the ultrastructure and immunophenotype of Schwann cells, but which contain melanosomes that are reactive for melanoma markers. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6546] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6547] "Mesenchymal, Non-Meningothelial Tumors are benign and malignant mesenchymal tumors originating in the CNS or the meninges and showing fibrous, fibrohistiocytic, adipose, myoid, endothelial, chondroid or osseous, but not meningothelial differentiation. Depending on their histological features and clinical behavior, their grade ranges from benign neoplasms (WHO grade I) to highly malignant sarcomas (WHO grade IV). (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6548] "Intracranial Liposarcoma is an extremely rare tumor that may be associated with subdural hematomas. Epidural Lipomatosis is a rare lesion that represents, not a neoplasm, but a metabolic response, often to chronic administration of steroids, and consists of diffuse hypertrophy of the spinal epidural adipose tissue. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6549] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6550] "Also known as chromophil carcinoma, it represents a minority of renal cell carcinomas.  It can be hereditary or sporadic.  The sporadic papillary renal cell carcinoma is characterized by trisomy of chromosomes 7, 16, and 17, and loss of chromosome Y.  The peak incidence is in the sixth and seven decades.  It is classified as type 1 or 2, based on the cytoplasmic volume and the thickness of the lining neoplastic cells. The prognosis is more favorable than for conventional (clear cell) renal cell carcinoma. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [6551] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6552] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6553] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6554] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6555] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6556] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6557] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6558] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6559] "This term is used when a complete mole or very rarely a partial mole invades the myometrium.  Clinical presentation includes: abnormal uterine ultra sound and either persistent or rising hCG levels. - 2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6560] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6561] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6562] "Oligoastrocytoma is a tumor (WHO grade II) composed of a conspicuous mixture of two distinct neoplastic cell types morphologically resembling the tumor cells in Oligodendroglioma and Diffuse Astrocytoma (WHO grade II). (WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6563] "Subependymoma (WHO grade I) is a benign, slow growing neoplasm which is typically attached to a ventricular wall. It is composed of glial tumor cell clusters embedded in an abundant fibrillary matrix with frequent microcystic change. Some lesions have the histological features of both subependymoma and ependymoma. It is often detected incidentally and has a very favorable prognosis. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [6564] "Embryonal tumors are a large and important fraction of pediatric brain tumors. The following histologically identifiable entities all develop on the background of an undifferentiated round-cell tumor but show a variety of divergent patterns of differentiation. It has been proposed that they be merged under the term primitive neuroectodermal tumors: Ependymoblastoma, Medulloblastoma and Supratentorial PNETs. Two other entities should be kept separate as they have a distinctly different histology and also appear to evolve by different genetic pathways: Medulloepithelioma and Atypical Teratoid/Rhabdoid Tumor. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                          
 [6565] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6566] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6568] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6569] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6570] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6571] "Hibernoma is a lipoma that originates from brown fat and is composed of uniform granular or multi-vacuolated cells with small, centrally placed nuclei. (WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6572] "Leiomyoma, a benign smooth muscle tumor, histologically, has a pattern of intersecting fascicles, composed of eosinophilic spindle cells with blunt-ended nuclei that often lack mitotic activity. Occasional tumors have nuclear palisading, but should not be mistaken for schwannomas. Diffuse Leptomeningeal Leiomyomas and the Angioleiomyomatous Variant have been described and several AIDS-associated cases have been reported. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [6573] "Intracranial Leiomyosarcomas, malignant smooth muscle tumors, generally arise in the dura, although one unique example originating in a pineal teratoma has been reported.  (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [6574] "Rhabdomyoma is a tumor that generally consists entirely of mature striated muscle. One reported Rhabdomyoma associated with a cranial nerve had a minor adipose tissue component. CNS Rhabdomyomas must be distinguished from skeletal muscle heterotopias, most of which occur within prepontine leptomeninges. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [6575] "Chondroma, Osteoma and Osteochondroma are benign osteocartilaginous tumors which are usually dura-based. Outside the CNS, they often develop in the skull and only secondarily displace dura and brain. Histologically, they correspond to similar tumors arising in bone, but should be differentiated from asymptomatic dural calcification, ossification related to metabolic disease or trauma, and neuroectodermal tumors such as astrocytoma and gliosarcoma that occasionally show osseous or chondroid differentiation. Conversion of a CNS chondroma to a chondrosarcoma has rarely been documented. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                  
 [6576] "The preferred sites of Osteosarcoma, a malignant tumor of bone, are the skull or spine and, more rarely, the meninges or the brain. The diagnosis is made by seeing direct formation of bone or osteoid by the proliferating tumor cells. Osteosarcomatous elements may rarely be found in germ cell tumors and gliosarcomas.  (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [6577] "Chondroma, Osteoma and Osteochondroma are benign osteocartilaginous tumors which are usually dura-based. Outside the CNS, they often develop in the skull and only secondarily displace dura and brain. Histologically, they correspond to similar tumors arising in bone, but should be differentiated from asymptomatic dural calcification, ossification related to metabolic disease or trauma, and neuroectodermal tumors such as astrocytoma and gliosarcoma that occasionally show osseous or chondroid differentiation. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6578] "Hemangiomas, tumors composed chiefly of blood vessels, vary in size from microscopic to massive. They are classified as capillary or cavernous, depending upon their histological appearance. Most hemangiomas that affect the CNS are primary lesions of bone that impinge secondarily on the CNS. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [6579] "Hemangiopericytoma (HPC) (generally, WHO grade II or III) of the central nervous system is a rare, highly cellular and richly vascularized tumor, almost always attached to the dura, and indistinguishable histologically from Hemangiopericytomas occuring in somatic soft tissues. It has a tendency to recur and to metastasize outside the CNS. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [6580] "Kaposi Sarcoma is a malignant neoplasm characterized by spindle-shaped cells lining or forming slit-like blood vessels. It is only rarely found as a parenchymal or meningeal tumor in the setting of AIDS, where it is often difficult to determine whether the lesion is primary or secondary. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [6581] "Capillary Hemangioblastoma (WHO grade I) is a tumor of uncertain histogenesis which is composed of stromal cells and abundant capillaries. Approximately 25% of Hemangioblastomas are associated with Von Hippel-Lindau disease, a disease inherited through an autosomal dominant trait and characterized by the development of Capillary Hemangioblastomas of the central nervous system and retina, clear cell renal carcinoma, pheochromocytoma, pancreatic and inner ear tumors. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [6582] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6583] "The pure Germinoma is the most common CNS Germ Cell Tumor.  It is composed of uniform cells resembling primitive germ cells.  These cells have large, vesicular nuclei, prominent nucleoli and a clear, glycogen-rich cytoplasm.  Additional features are lymphoid or lymphoplasmacellular infiltrates and, less frequently, scattered syncytiotrophoblastic giant cells.  (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [6584] "Embryonal Carcinoma is composed of large cells that proliferate in cohesive nests and sheets, form abortive papillae, or line irregular, gland-like spaces. In rare occasions, tumor cells may replicate the structure of the early embryo, forming \"embryoid bodies\" replete with germ discs and miniature amniotic cavities. The tumors also have enlarged nucleoli, abundant clear to somewhat violet-hued cytoplasm, a high mitotic rate and zones of coagulative necrosis.  (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [6585] "Yolk Sac Tumor is composed of primitive-appearing epithelial cells - putatively representing yolk sac endoderm - set in a loose, variably cellular, and often conspicuously myxoid matrix, resembling extra-embryonic mesoblast. Eosinophilic hyaline globules immunoreactive for AFP are a diagnostic feature. (WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [6586] "Choriocarcinoma is characterized by extra-embryonic differentiation along trophoblastic lines. The diagnosis requires the identification of cytotrophoblastic elements, as well as syncitiotrophoblastic giant cells. (WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [6587] "Mature Teratomas are tumors composed exclusively of fully differentiated, 'adult-type' tissue elements that are sometimes arranged in a pattern resembling normal tissue relationships. Mitotic activity is low or absent. The more common ectodermal components found in Mature Teratomas include skin, brain and choroid plexus. The more common mesodermal components include cartilage, bone, fat and muscle (both smooth and striated). And the most common endodermal components are cysts lined by epithelia of respiratory or enteric type and in some cases pancreatic or hepatic tissue.  (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                            
 [6588] "Immature Teratoma is a variant of Teratoma composed of incompletely differentiated components resembling fetal tissues. Even if the immature component is only a minor element of an otherwise differentiated tumor, the tumor is still classified as immature. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6589] "The term 'Teratoma with Malignant Transformation' is a generic designation for the occasional teratomatous neoplasm that contains as an additional malignant component a cancer of conventional somatic type. This malignant component is most often a rhabdomyosarcoma or an undifferentiated sarcoma and less often a squamous cell carcinoma or enteric-type adenocarcinoma. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6590] "These rare Germ Cell Tumors contain mixtures of two or more types of germ cell neoplasia. (Adapted from AFIP Fascicle #23.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [6591] "Granular Cell Tumor of the Neurohypophysis (WHO grade I) is a generally benign intrasellar and/or suprasellar mass arising from the Neurohypophysis or infundibulum, composed of nests of large cells with granular, eosinophilic cytoplasm due to abundant intracytoplasmic lysosomes. It generally has a slow progression and lacks invasive growth. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [6592] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6593] "Trilateral retinoblastoma refers to bilateral (or less often unilateal) retinoblastoma associated with an intracranial primitive neuroectodermal tumor in the pineal or suprasellar region. This syndrome is often associated with a increased familial incidence of retinoblastoma. (From Cancer 86(1): 135-141, 1999)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [6594] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6595] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6596] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6597] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6598] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6599] "Barrett's Adenocarcinoma is an adenocarcinoma arising from Barrett's metaplastic epithelium in the esophagus.  There is evidence supporting the idea that the Barrett's adenocarcinomas develop through a stepwise progression through intestinal metaplastic epithelium to epithelial dysplasia to malignancy.  Adenocarcinomas arising in the setting of Barrett's esophagus are typically papillary and/or tubular.  In terms of grading, they are well or moderately differentiated adenocarcinomas. -- 2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6600] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6601] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6602] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6603] "A rare morphologic variant of esophageal squamous cell carcinoma.  Histologically, it is composed of closely packed cells with hyperchromatic nuclei and scant basophilic cytoplasm. It has a similar prognosis to the conventional squamous cell carcinoma of the esophagus.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [6604] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6605] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6607] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6608] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6609] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6610] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6611] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6612] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6613] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6614] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6615] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6616] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6617] "Benign and malignant hormone producing neoplasms of the pituitary gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [6618] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6619] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6620] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6621] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6622] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6623] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6624] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6625] "A neoplasm of immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage.  Neoplasms involving the bone marrow and the peripheral blood are called precursor lymphoblastic leukemias or acute lymphoblastic leukemias.  Neoplasms involving primarily lymph nodes or extranodal sites are called lymphoblastic lymphomas. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [6626] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6627] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6628] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6629] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6630] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6631] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6632] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6633] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6634] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6635] "A neoplasm composed of a lymphocytic cell population which is usually malignant (clonal) by molecular genetic and/or immunophenotypic analysis.  Lymphocytic neoplasms include Hodgkin's and Non-Hodgkin's lymphomas and acute and chronic lymphocytic leukemias. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [6636] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6637] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6638] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6639] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6640] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6641] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6642] "A malignant neoplasm composed of large cells with large nuclei, prominent nucleoli, and abundant pale cytoplasm (Paget cells).  Paget's cell neoplasms include Paget's disease of the nipple and extramammary Paget's disease which may affect the vulva, penis, anus, skin and scrotum. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6643] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6644] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6645] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6646] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6647] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6648] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6649] "Prostate tumor cells spreading and reestablishing themselves in another organ"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6650] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6651] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6652] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6653] "A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865) This concept specifically refers to a tumor in the small intestine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [6654] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6655] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6656] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6657] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6658] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6659] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6660] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6661] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6662] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6663] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6664] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6665] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6666] "Metastatic disease. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [6667] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6668] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6669] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6670] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6671] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6672] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6673] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6674] "The reemergence of hepatic neoplasm malignant after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [6675] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6676] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6677] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6678] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6679] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6680] "Stage I includes: T1, N0, M0.  T1: Solitary tumor without vascular invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [6681] "Stage II includes: T2, N0, M0.  T2: Solitary tumor with vascular invasion or multiple tumors none more than 5 cm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [6682] "Stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0); IIIC: (Any T, Any N, M0).  IIIA: T3: Multiple tumors more than 5 cm or tumor involving a major branch of the portal or hepatic vein(s).  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: Distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6683] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6684] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6685] "Stage IV includes (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [6686] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6687] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6688] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6689] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6690] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6691] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6692] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6693] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6694] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6695] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6696] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6697] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6698] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6699] "This is a rare malignant neoplasm of the soft tissue.  It is typically a disease of children and young adults.  Characterized by t(11:22) (q24: q12) cytogenic abnormality expressing EWS/FLI-1 chimeric transcript.  Most commonly occurs in the paravertebral region, chest wall, pelvis and lower extremities.  Treatment includes local excision with consideration for post operative chemotherapy and/or radiotherapy. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6700] "A localized tumor consisting of mature mast cells. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [6701] "A form of mastocytosis characterized by mast cell infiltration of the skin.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6702] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6703] "In internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves only 1 quadrant; 3 adjoining liver quadrants are free of tumor. (from PDQ 2004)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [6704] "In internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves 2 adjoining quadrants; 2 adjoining quadrants are free of tumor. (from PDQ 2004)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [6705] "In internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves 3 adjoining quadrants or 2 nonadjoining quadrants; 1 quadrant or 2 nonadjoining quadrants are free of tumor. (from PDQ 2004)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [6706] "In internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves all 4 quadrants; there is no quadrant free of tumor. (from PDQ 2004)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [6707] "Distant metastases, regardless of the extent of liver involvement. (from PDQ 2004)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [6708] "No distant metastases, tumor unresectable or resected with gross residual tumor, or positive lymph nodes. (from PDQ 2004)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [6709] "No metastases, tumor grossly resected with microscopic residual disease (i.e., positive margins); or tumor rupture, or tumor spill at the time of surgery. (from PDQ 2004)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [6710] "No metastases, tumor completely resected. (from PDQ 2004)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [6711] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6712] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6713] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6714] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6715] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6716] "(eh-RITH-ro-loo-KEE-mee-a) Cancer of the blood-forming tissues in which large numbers of immature, abnormal red blood cells are found in the blood and bone marrow."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6717] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6718] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6719] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6720] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6721] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6722] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6723] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6724] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6725] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6726] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6727] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6728] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6729] "A myelodysplastic syndrome defined by 5-9% blasts in the bone marrow, and <5% blasts in the blood.  Approximately 25% of cases progress to an acute leukemia.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [6730] "A myelodysplastic syndrome defined by 10-19% blasts in the bone marrow or 5-19% blasts in the blood and <10% blasts in the bone marrow.  Approximately 33% of cases progress to acute leukemia.  The prognosis is usually poor.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [6731] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6732] "An acute myeloid leukemia in which the majority of monocytic cells are promonocytes.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [6733] "An acute myeloid leukemia in which the monoblasts represent 80% or more of the total cellular population.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [6734] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6735] "Diffuse Astrocytoma is a low-grade (WHO grade II) astrocytic neoplasm, previously called 'astrocytoma'.  It is characterized by a high degree of cellular differentiation, slow growth, and diffuse infiltration of neighboring brain structures. These lesions typically affect young adults and have an intrinsic tendency for malignant progression to anaplastic astrocytoma and, ultimately, glioblastoma. According to the prevailing cells type, three major variants can be distinguished: Fibrillary Astrocytoma, Gemistocytic Astrocytoma, and Protoplasmic Astrocytoma. (Adapted from WHO)"                                                                                                                                                                                                                                                                                                                                                                                              
 [6736] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6737] "A group of acute myeloid leukemias (AMLs) characterized by recurrent genetic abnormalities, mainly balanced translocations.  This group of AMLs often has a high rate of complete remission, and favorable prognosis.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [6738] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6739] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6740] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6741] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6742] "A benign lipomatous neoplasm.  The spindle cell and pleomorphic variants represent morphologically opposite ends of the same entity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [6743] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6744] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6745] "A lymphoproliferative disorder that develops in patients who are immunosuppressed with methotrexate.  This disorder is often Epstein-Barr virus positive, and morphologically it may resemble large B-cell non-Hodgkin's lymphoma, Hodgkin's lymphoma, or a polymorphous post-transplant lymphoproliferative disorder. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [6746] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6747] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6748] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6749] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6750] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6751] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6752] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6753] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6754] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6755] "This entity represents a spectrum of lymphoproliferative disorders characterized by CD30 (Ki-1)-positive cutaneous T-cell infiltrates.  The two ends of the spectrum include lymphomatoid papulosis (benign end) and primary cutaneous anaplastic large cell lymphoma (malignant end).  Borderline lesions are also included in this spectrum.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6756] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6757] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6758] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6759] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6760] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6761] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6762] "An aggressive Non-Hodgkin's adult lymphoma, comprised of two clinical syndromes: nasal T-cell lymphoma (previously called lethal midline granuloma) and pulmonary angiocentric B-cell lymphoma (previously called lymphomatoid granulomatosis). (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [6763] "An aggressive mature T-cell non-Hodgkin's lymphoma, composed of cells with a lymphoblast-like morphology and evidence of commitment to the NK lineage.  Patients usually present with extranodal, most commonly cutaneous tumors.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [6764] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6765] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6766] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6767] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6768] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6769] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6770] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6771] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6772] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6773] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6774] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6775] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6776] "A primary follicular lymphoma of the skin.  Cutaneous follicle center lymphoma is one of the most common types of cutaneous B-cell lymphoma, it is often BCL-2 negative, and it tends to remain localised to the skin.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [6777] "A follicular lymphoma involving the skin.  A cutaneous follicular lymphoma may be metastatic to the skin from the lymph nodes or other anatomic sites or primary (cutaneous follicle center lymphoma). --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6778] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6779] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6780] "Hodgkin's lymphoma involving the skin.  The vast majority of cases represent metastatic Hodgkin's lymphoma to the skin from the lymph nodes or other anatomic sites.  Primary Hodgkin's lymphoma of the skin is rare and there are only a few well documented cases reported. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [6781] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6782] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6783] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6784] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6785] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6786] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6787] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6788] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6789] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6790] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6791] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6792] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6793] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6794] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6795] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6796] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6797] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6798] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6799] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6800] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6801] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6802] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6803] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6804] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6805] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6806] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6807] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6808] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6809] "Malignant neoplasms of the testicles"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [6810] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6811] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6812] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6813] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6814] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6815] "A monoclonal B-cell neoplasm which is characterized by a nodular, or a nodular and diffuse, polymorphous proliferation of scattered large neoplastic cells known as popcorn or L&H cells.  Patients are predominantly male, frequently in the 30-50 year age group.  The prognosis of patients with stage I and stage II disease is very good.  Advanced stages have an unfavorable prognosis.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6816] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6817] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6818] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [6819] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [6820] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6821] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6822] "An aggressive Non-Hodgkin's adult lymphoma, formerly called angioimmunoblastic lymphadenopathy with dysproteinemia (AILD). Characterized by clonal T-cell receptor gene rearrangement.  Frequent opportunistic infections due to an underlying immunodeficiency. (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [6823] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6824] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6825] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6826] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6827] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6828] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6829] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6830] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6831] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6832] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6833] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6834] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6835] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6836] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6837] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6838] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6839] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6840] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6841] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6842] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6843] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6844] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6845] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6846] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6847] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6848] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6849] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6850] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6851] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6852] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6853] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6854] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6855] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6856] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6857] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6858] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6859] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6860] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6861] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6862] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6863] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6864] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6865] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6866] "Acute myeloid leukemia's (AMLs) in which 80% or more of the leukemic cells are of monocytic lineage.  Bleeding disorders are common presenting features.  These AMLs usually follow an aggressive clinical course.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [6867] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6868] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6869] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6870] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6871] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6872] "Stage 0: pTis, N0, M0, S0.  pT0: No evidence of primary tumor (e.g., histologic scar in testis).  No regional lymph node metastasis.  M0: No distant metastasis. S0: Marker study levels within normal limits. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [6873] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6874] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6875] "This is a malignant tumor of the testis.  It is a type of germ cell tumor.  It is believed that it is derived from the sexually undifferentiated embryonic gonad.  There are two histologic variants classical and spermatocytic.  The causes of germ cell tumors are unknown.  Treatment with radiotherapy is highly successful when the tumor is diagnosed in localized stages, which represents the majority of presentations of seminoma. -2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6876] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6877] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6878] "Stage 2 includes anypT,N1-3,M0,SX.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6879] "Stage 3 includes any T, any N, M1,SX.  M1: distant metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [6880] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6881] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6882] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6884] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6885] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6886] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6887] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6888] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6889] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6891] "This category includes intermediate fibrohistiocytic neoplasms that affect the dermis and the subcutaneous tissues. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [6892] "A general term for the abnormal growth of squamous cells on the surface of the cervix. The changes in the cells are described as low grade or high grade, depending on how much of the cervix is affected and how abnormal the cells are. Also called SIL."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [6893] "Staging is classification AJCC. Stage 0 includes Tis,NO,MO.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [6894] "This lesion shows moderate or marked architectural distortion with glandular crowding and prominent cellular atypia.  It includes moderate dysplasia and carcinoma in situ (severe dysplasia).  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6895] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6896] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6897] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6898] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6899] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6900] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6901] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6902] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6903] "An adenocarcinoma arising from the uterine body cavity.  This is the most frequent malignant tumor affecting the uterine body, and is linked to estrogen therapy.  Most patients present with uterine bleeding and are over age 40 at the time of diagnosis.  The prognosis depends on the stage of the tumor, the depth of the uterine wall invasion, and the histologic subtype.  Endometrioid adenocarcinoma is the most frequently seen morphologic variant of endometrial adenocarcinoma. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [6904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6906] "An infiltrating breast carcinoma associated with stromal fibrosis. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [6907] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6910] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6911] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6912] "Abnormal malignant growth of cells in the paraurethral glands."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [6913] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6914] "Nonkeratinizing nasopharyngeal carcinoma is defined as a carcinoma with cells at differing levels of maturation but lacking light microscopic evidence of squamous differentiation (Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999). --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [6915] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6916] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6917] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6918] "Malignant growth of cells comprising the tissue of the lung"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [6919] "A malignant tumor involving the prostate gland.  The vast majority are carcinomas. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [6920] "Cancer relating to the anus.  Tumors of the anal margin (below the anal verge and involving the perianal hair-bearing skin) are classified with skin tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [6921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6922] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6923] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6924] "An invasive or non-invasive transitional cell carcinoma of the urinary bladder.  It is classified as low - or high-grade. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [6925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6926] "A thymoma that is confined within the capsule and may display benign or malignant morphologic characteristics. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [6927] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6928] "Benign and malignant neoplasms that arise from vascular tissue including arteries, veins, venous sinuses, arterioles and capillaries.  These lesions may occur in essentially any body location. (KEV 8-7-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6929] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6932] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6933] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6934] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6935] "Cancer confined to the nasopharynx."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6936] "Cancer that has spread to lymph nodes on both sides of the neck or has spread to nearby bones or sinuses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [6937] "Stage IV includes: IVA: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0); IVB (Any T, N3, M0); IVC (Any T, Any N, M1). T4: Tumor with intracranial extension and/or involvement of cranial nerves, infratemporal fossa, hypopharynx, orbit, or masticator space.  N3: Metastasis in a lymph node(s).  N3a: greater than 6 cm in dimension.  N3b: extension to the supraclavicular fossa.  M1: Distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [6938] "Malignant neoplasms of the oral cavity and pharynx"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [6939] "A type of polyp that grows in the colon and other places in the gastrointestinal tract and sometimes in other parts of the body. These adenomas may become malignant (cancerous)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [6940] "A rare, fast-growing cancer of the blood.  Also called B-cell acutelymphocytic leukemia or B-cell acute lymphoblastic leukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [6941] "A rare variant of Hairy Cell Leukemia in which the circulating lymphocytes have a round or oval nucleus and a prominent nucleolus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [6942] "A rare neoplasm of small B-lymphocytes with \"hairy\" projections in bone marrow, spleen and peripheral blood.  Most patients are middle-aged to elderly adults and present with splenomegaly and pancytopenia. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6943] "Malignant neoplasm of the tonsils"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [6944] "(GAS-trik AT-ro-fee) A condition in which the stomach muscles shrink and become weak. The digestive (peptic) glands may also shrink, resulting in a lack of digestive juices."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [6945] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6946] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6948] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6949] "A malignant tumor involving the vagina.  Representative examples include carcinomas and sarcomas. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [6950] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6951] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6952] "So-called nephrogenic adenoma is a distinct metaplastic lesion of the urothelium characterized by aggregates of cuboidal or hobnail cells.  These cells line thin papillary fronds on the surface or form tubular structures within the lamina propria."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [6953] "Villous adenoma of the urinary bladder is a metaplastic villous lesion of the urothelium.  Although it is called an adenoma, it is not a true adenomatous polyp."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6954] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6955] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6956] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6957] "Any malignant neoplasm of the rectum, primary or metastatic.  Rectal Cancer normally refers only to carcinomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [6958] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6959] "A malignant tumor involving the rectum and sigmoid colon.  The majority are carcinomas. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [6960] "A colorectal carcinoma involving the rectosigmoid area.  The majority are adenocarcinomas.  About 50% of colorectal carcinomas occur in the rectosigmoid area.  --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [6961] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6963] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6965] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6966] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6968] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6969] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6970] "A primary or metastatic malignant tumor involving the ovary.  Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors.  Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [6971] "Abnormal growth of the cells of the cervix with malignant characteristics. This concept specifically refers to this type of cancer in patients with acquired immunodeficiency syndrome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [6972] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6973] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6974] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6975] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6976] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6977] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6979] "A benign epithelial neoplasm that projects above the surrounding epithelial surface and consists of villous or arborescent outgrowths of fibrovascular stroma. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [6980] "A rare benign tumor composed of sheets and islands of spindle, plasmacytoid, epithelioid, and clear cells that exhibit myoepithelial but not ductal differentiation. The average age of patients has been reported as 44 years. Clinically, these tumors present as asymptomatic masses. Discrimination between myoepithelioma and myoepithelial carcinoma is based primarily on the infiltrative growth of the latter. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [6981] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6982] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6984] "Abnormal growth of the glial cells that comprise the brainstem. This tumor is most easily detected on MRI. The form with the poorest prognosis (median survival of about 12 months) appears to be the diffusely infiltrative pontine lesion. However, it is important to note whether the patient has neurofibromatosis since the literature appears to show a more favorable prognosis for diffuse tumors in patients with neurofibromatosis type I.  The dorsally exophytic brainstem lesions has a slightly better expected survival. Brainstem glioma is most commonly found in children. There are preliminary findings in the literature that seem to indicate that adults with brainstem gliomas may have a better survival time. (Kaye AH, Laws ER Brain Tumors Churchill-Livingstone 1995)"                                                                                                                                                                                                
 [6985] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6986] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6988] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6991] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6993] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6994] "The spread of the cancer to the ovary.  This may be from a primary ovarian cancer involving the opposite ovary, or from a cancer at a distant site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [6995] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6998] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [6999] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7000] "A benign, corticotropin secreting pituitary tumor.  It can be associated with Cushing's syndrome. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [7001] "An acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors.  Patients typically present with anemia, thrombocytopenia, fever and fatigue.  This type of leukemia frequently responds to aggressive therapy.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7002] "An acute leukemia in which the blasts lack sufficient evidence to classify as myeloid or lymphoid or they have morphologic and/or immunophenotypic characteristics of both myeloid and lymphoid cells.  The prognosis is usually unfavorable.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7004] "Acute erythroid leukemia that is responding to therapy, i.e. It is not progressing and possibly regressing"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7005] "Acute erythroid leukemia characterised by the presence of immature erythroid cells in the bone marrow (at least 80% of the cellular component), without evidence of a significant myeloblastic cell population present. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7007] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7008] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7009] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7010] "A carcinoma arising in the anal margin or perianal skin (below the anal verge and involving the perianal hair-bearing skin).  It includes basal cell and squamous cell carcinoma.  Anal margin carcinoma is staged as a skin carcinoma, separately from anal canal carcinoma.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7011] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7012] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7013] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7014] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7015] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7016] "A malignant growth of cells in the esophagus. There are two major variants: epidermoid (squamous) carcinoma and adenocarcinoma. This is an uncommon cancer in the United States though it is relatively common in Iran, France, Switzerland with highest mortality rates seen in China, Singapore, and Puerto Rico. Excessive ethanol and cigarette usage increases the risk for development of this cancer, acting in a synergistic fashion. (DeVita et al. Cancer. p.776-778 4th edition Lippincott)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7017] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7018] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7019] "Primary or metastatic malignant neoplasm of the gallbladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [7020] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7021] "A malignant tumor involving the extrahepatic bile duct. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7022] "A malignant tumor involving the larynx.  The majority are carcinomas. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7023] "Abnormal growth, with malignant characteristics, of the cells that comprise the lips of the mouth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7024] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7025] "Malignant neoplasm of the nasal cavity"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7026] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7027] "A squamous cell carcinoma or less frequently an adenocarcinoma, often associated with human papilloma virus (HPV) infection.  Homosexual men are at particular risk.  The most important prognostic factors are tumor stage and nodal status.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7028] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7029] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7030] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7031] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7032] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7033] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7034] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7035] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7036] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7037] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7038] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7039] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7040] "Primary or metastatic malignant neoplasm involving the vulva. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7041] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7042] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7043] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7044] "A myelodysplastic syndrome with 5-19% myeloblasts in the bone marrow.  It includes two categories: RAEB-1, and RAEB-2.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7045] "Abnormal malignant growth of cells in the urethra (lower urinary tract)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7046] "The reemergence of urethral cancer after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7047] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7048] "A malignant growth within the thyroid gland. It may be associated with thyroid hormone secretion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7049] "The spread of the cancer to the breast. This may be from a primary breast cancer on the opposite side, or from a cancer at a distant site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7050] "Esophageal segments used primarily for clinical purposes, and distinct from the topographic segments used in pathology."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7051] "Esophageal segments used primarily in pathology, and distinct from the anatomic segments used for clinical purposes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7052] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7053] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7054] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7055] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7056] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7057] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7058] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7059] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7060] "Malignant neoplasm originating in the small intestine"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7061] "The spread of the cancer to the small intestine.  This may be from a primary intestinal cancer, or from a cancer at a distant site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [7062] "Abnormal malignant growth of the cells within the renal pelvis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7063] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7064] "A malignant neoplasm originating from the apical lung. Most malignant superior sulcus neoplasms are bronchogenic carcinomas. This tumor may be associated with Pancoast syndrome. Also known as Pancoast tumor. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7065] "A mature T-cell non-Hodgkin's lymphoma, characterized by systemic disease and a polymorphous infiltrate involving lymph nodes.  It occurs in the middle aged and elderly, with an equal incidence in males and females.  The clinical course is typically aggressive.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7066] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7067] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7068] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7069] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7070] "Abnormal growth of cells that comprise the optic tract. This condition can be seen in association with Neurofibromatosis 1. It is most commonly seen in the pediatric age group."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7071] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7072] "An abnormal growth of the cells that comprise the optic tract.  It presents most commonly in the first two decades of life. It is associated with Neurofibromatosis 1 (NF1 .)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7073] "Desmoplastic Medulloblastoma is a variant of Medulloblastoma. Some histologic features of this lesion include nodular, reticulin-free zones ('pale islands') surrounded by densely packed, highly proliferative cells that produce a dense intercellular reticulin fiber network. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7074] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7075] "A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood.  This category includes precursor or acute lymphoblastic leukemias and chronic leukemias. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7076] "An indolent non-Hodgkin's lymphoma composed of monomorphic small, round B-lymphocytes in the lymph nodes.  When the lymphoid process involves predominantly the bone marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [7077] "A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. --2004"                                                                                                                                                                                                                                                                                             
 [7078] "A primitive neuroectodermal tumor (small round blue cell tumor) of the thorax which can involve the periosteum, thoracic wall and/or pleura though it spares the lung parenchyma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7079] "A primary or metastatic malignant tumor involving the ureter.  The majority are carcinomas. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [7080] "A malignant tumor that has spread to the ureter from another anatomic site. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7081] "Malignant neoplasm of the pharynx."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7082] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7083] "Primary or metastatic malignant neoplasm involving the penis. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7084] "Primary or metastatic malignant neoplasm involving the kidney. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7085] "The spread of the cancer to the kidney.  This may be from a primary kidney cancer involving the opposite kidney, or from a cancer at a distant site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7086] "Ovarian serous adenocarcinoma is a serous neoplasm characterized by nuclear atypia, high mitotic activity, stratification, glandular complexity, branching papillary fronds and stromal invasion. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7087] "Cancer cells have spread outside the covering (capsule) of the prostate to tissues around the prostate but not to the lymph nodes. The glands that produce semen (the seminal vesicles) may have cancer cells in them. Similar to stage C in the Whitmore-Jewett staging system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7088] "Tumor is clinically localized to the periprostatic area, but extends through the prostatic capsule; the seminal vesicles may be involved. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7089] "Cancer that may be found by a needle biopsy performed because a blood test showed elevated prostate-specific antigen (PSA); or cancer that may be felt in the prostate during a rectal examination, even though the cancer cells are found only in the prostate gland. Similar to stage B in the Whitmore-Jewett staging system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7090] "Tumor is clinically palpable but confined to the prostate. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7091] "Cancer that is only in the prostate gland, cannot be felt during a digital rectal examination, is not visible by imaging, and causes no symptoms.  It is usually found accidentally or because a blood test showed an elevated prostate-specific antigen (PSA) level.  Cancer cells may be found in only one area of the prostate, or they may be found in many areas of the prostate.  Similar to stage A in the Whitmore-Jewett staging system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7092] "A clinically undetectable tumor confined to the prostate gland, normally an incidental finding during surgery. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7093] "A malignant tumor arising from the epithelium that lines the cavity of the uterine body.  The vast majority of endometrial carcinomas are adenocarcinomas; squamous cell and adenosquamous carcinomas represent a minority of the cases.  Endometrioid adenocarcinoma is the most frequently seen variant of endometrial adenocarcinoma.  Uterine bleeding is an initial clinical sign.  The prognosis depends on the stage of the tumor, the depth of myometrial wall invasion, and the degree of differentiation. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7094] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7095] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7096] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7097] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7098] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7099] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7100] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7101] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7102] "Also known as thymic carcinoma, this type of thymoma displays the morphologic characteristics of a carcinoma (not well-differentiated). --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7103] "(NEE-vus) A benign growth on the skin, such as a mole. A mole is a cluster of melanocytes and surrounding supportive tissue that usually appears as a tan, brown, or flesh-colored spot on the skin. The plural of nevus is nevi (NEE-vye)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7104] "This is a skin neoplasm composed of clusters of benign nevus cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [7105] "A recently described type of renal cell carcinoma, affecting mostly young African-Americans.  It is located in the medulla of the kidney, and follows an aggressive clinical course.  Most reported cases have shown metastatic disease at the time of diagnosis. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [7106] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7107] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7108] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7109] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7110] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7111] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7112] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7113] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7114] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7115] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7116] "(fa-MI-lee-yul dis-PLAS-tik NEE-vye) A condition that runs in certain families in which at least two members have dysplastic nevi (atypical moles) and have a tendency to develop melanoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7117] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7118] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7119] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7120] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7121] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7122] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7123] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7124] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7125] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7126] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7127] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7128] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7129] "Stage IV includes: IVA: (T4, Any N, M0) and IVB: (Any T, Any N, M1).  T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify tumor as T4.) M1: Distant metastasis.  (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7130] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7131] "An acute myeloid leukemia (AML) with at least 20% blasts in the marrow or blood, and dysplasia in 2 or more myeloid cell lines.  Dysplasia must be present in at least 50% of the cells of at least 2 cell lines.  Patients with this type of AML often present with severe cytopenia.  The presence of multilineage dysplasia has an adverse effect on the probability of achieving complete remission.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7132] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7133] "A benign melanocytic nevus with a halo appearance. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [7134] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7135] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7136] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7137] "A benign or malignant tumor involving the oral cavity and/or the lips. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7138] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7139] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7140] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7141] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7142] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7143] "A thymoma that has an aggressive clinical course (capsular invasion, infiltration of the surrounding tissues) and can metastasize.  Although any morphologic subtype of thymoma may eventually have a malignant clinical course, this term is most often associated with thymoma types B3 and C.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7144] "Primary cutaneous Hodgkin's lymphoma is rare.  This diagnosis can only be made when there is no evidence of Hodgkin's lymphoma in the lymph nodes or other anatomic sites.  Patients usually present with papules or nodular lesions.  Morphologically, primary cutaneous Hodgkin's lymphoma may resemble lymphomatoid papulosis or anaplastic large cell lymphoma.  Immunohistochemical tissue evaluation is essential in establishing the diagnosis. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7145] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7146] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7147] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7148] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7149] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7150] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7151] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7152] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7153] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7154] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7155] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7156] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7157] "The reemergence of pancreatic carcinoma after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7158] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7159] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7160] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7161] "A lipomatous neoplasm characterized by a high risk of local recurrence and no risk of metastasis. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [7162] "This is a rare tumor.  Approximately 100 to 150 cases have been reported in the literature.  In most cases the diagnosis is made at autopsy or postoperatively.  Clinical signs and symptoms include: pericardial effusion, congestive heart failure, a mass or tamponade.  The prognosis for pericardial mesothelioma is extremely poor due to its late presentation and difficulty in completely removing it surgically.  Surgical resection remains the treatment of choice.  Addition of chemotherapy or radiation have been disappointing. - 2002"                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7163] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7164] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7165] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7166] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7167] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7168] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7169] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7170] "Abnormal malignant growth of cells in the urethra (lower urinary tract) that has not spread."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [7171] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7172] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7173] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7174] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7175] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7176] "A carcinoma entirely confined to the ducts.  While intraductal (or DCIS) carcinomas can arise at other sites, these terms are universally used to refer to carcinomas of the breast."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7177] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7178] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7179] "Cancer found only in the tissues that make up the wall of the gallbladder. Localized gallbladder cancer can be removed completely in an operation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7180] "Stage IV includes T4b, NO,MO/any T NI, MO/ any T N2 MO,/ any T N3 MO/ any T any N M1: T4b: Tumor invades the pelvic wall, abdominal wall.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension.  M1: Distant metastasis (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7181] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7182] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7183] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7184] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7185] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7186] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7187] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7188] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7189] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7190] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7191] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7192] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7193] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7194] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7195] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7196] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7197] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7198] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7199] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7200] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7201] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7202] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7203] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7204] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7205] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7206] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7207] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7208] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7209] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7210] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7211] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7212] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7213] "A carcinoma entirely confined to the ducts.  While intraductal (or DCIS) carcinomas can arise at other sites, these terms are universally used to refer to carcinomas of the breast."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7214] "A carcinoma entirely confined to the ducts.  While intraductal (or DCIS) carcinomas can arise at other sites, these terms are universally used to refer to carcinomas of the breast."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7215] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7216] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7217] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7218] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7219] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7220] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7221] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7222] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7223] "A rare type of breast cancer in which breast cancer cells block the lymph vessels in the skin of the breast. The breast becomes red, swollen, and warm, and the skin of the breast may appear pitted or have ridges."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7224] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7225] "These are circumscribed lesions, composed of tubular and/or villous structures showing intraepithelial neoplasia.  The frequency of malignant transformation depends on the size and the histological grade.  It occurs in approximately 25% of lesions measuring <2 cm and in 40-50% of lesions >2 cm.  Gastric adenomas are classified as tubular, tubulovillous, and villous. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7226] "Ovarian adenocarcinoma is the most common type of ovarian carcinoma.  It includes the serous and mucinous adenocarcinomas, the clear cell adenocarcinoma and the endometrioid adenocarcinoma. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7227] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7228] "Hodgkin's lymphoma occuring in adults."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7229] "An abnormal growth of the cells that comprise the tissues of the brain in a person less than twenty one years old. This term does not specify whether the growth is benign or malignant nor does it specify location."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7230] "Non-Hodgkin's lymphoma occuring in adults."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7231] "Rhabdomyosarcoma occuring in childhood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7232] "Non-Hodgkin's lymphoma occuring in childhood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7233] "Soft tissue sarcoma occuring in adults."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7234] "Hepatoblastoma or hepatocellular carcinoma developed in childhood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7235] "A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract; approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7236] "An abnormal growth of the cells that comprise the tissues of the brain. This term does not specify whether the growth is benign or malignant nor does it specify location. It is limited to persons aged greater than twenty one years."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7237] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7238] "A malignant neoplasm that arises from the pigmented cells of the uveal tract of the eye.  The peak incidence of this tumor is in the 6th decade of life and they are most frequent in caucasians.  Clinically the lesions may present with visual loss or be identified during routine ocular examination.  They may be locally invasive or metastasize to distant sites.  Histologically, ocular melanomas are characterized by spindle cells featuring elongated nuclei and minimal cytoplasm or epithelioid cells which are pleomorphic, have enlarged nuclei and prominent cytoplasm. The later may be referred to as \"non-spindle cell\" melanomas. (From: Cancer Control; JMCC 5(4):299-309, 1998)"                                                                                                                                                                                                                                                                                          
 [7239] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7240] "Hodgkin's lymphoma occuring in childhood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [7241] "Soft tissue sarcoma occuring in childhood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7242] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7243] "Presence of fluid in the pericardial space as a complication of malignant disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7244] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7245] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7246] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7247] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7248] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7249] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7250] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7251] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7252] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7253] "A condition in which plasma cells secrete immunoglobulin light chains of only one type, kappa or lambda. Light chain deposition disease is often associated with multiple myeloma or lymphoproliferative disease, but as many as 50% of patients have no evidence of neoplastic plasma cell proliferation. Light chains excreted in the urine are known as Bence Jones protein. Amyloidosis and severe renal failure occur more frequently than in multiple myeloma. Also known as Bence Jones myeloma. L-chain disease, L-chain myeloma, and LCDD. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7254] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7255] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7256] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7257] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7258] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7259] "This entity, which represents the rarest of the testicular germ cell tumors, is histologically characterized by syncytiotrophoblasts and cytotrophoblasts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7261] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7262] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7263] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7264] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7265] "A dimpled condition of the skin of the breast, resembling the skin of an orange, sometimes found in inflammatory breast cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7266] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7267] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7268] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7269] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7270] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7272] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7273] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7274] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7276] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7277] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7278] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7279] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7280] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7281] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7282] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7283] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7284] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7285] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7286] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7287] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7288] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7289] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7290] "Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7291] "Cancer no bigger than 2 centimeters (about 1 inch) that has not spread outside the breast."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7292] "Stage II breast cancer means one of the following: cancer is no larger than 2 centimeters but has spread to the lymph nodes in the armpit (the axillary lymph nodes); cancer is between 2 and 5 centimeters (1 to 2 inches) and may have spread to the lymph nodes in the armpit; cancer is larger than 5 centimeters (2 inches) but has not spread to the lymph nodes in the armpit."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7293] "Stage III is divided into stages IIIA and IIIB. In stage IIIA breast cancer, the cancer (1) is smaller than 5 centimeters (2 inches) and has spread to the lymph nodes in the armpit, which have grown into each other or into other structures and are attached to them; or (2) is larger than 5 centimeters and has spread to the lymph nodes in the armpit.  In stage IIIB breast cancer, the cancer (1) has spread to tissues near the breast (skin, chest wall, including the ribs and the muscles in the chest); or (2) has spread to lymph nodes inside the chest wall along the breast bone."                                                                                                                                                                                                                                                                                                                                                                                               
 [7294] "Stage IIIA breast cancer is defined by either of the following: (1) the cancer is smaller than 5 centimeters (2 inches) and has spread to the lymph nodes under the arm, which have grown into each other or into other structures and are attached to them; (2) the cancer is larger than 5 centimeters and has spread to the lymph nodes under the arm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [7295] "The reemergence of neoplasms in the breast after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7296] "Cancer that is in the second or third layers of the stomach wall and has not spread to lymph nodes near the cancer, or is in the second layer of the stomach wall and has spread to lymph nodes very close to the tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7297] "Stage II includes: (T1, N2, M0), (T2a/b, N1, M0), (T3, N0, M0).  T1: Tumor invades lamina propria or submucosa. T2: Tumor invades muscularis propria or submucosa.  T2a: Tumor invades muscularis propria.  T2b: Tumor invades subserosa.  T3: Tumor penetrates serosa (visceral peritoneum) without invasion of adjacent structures. N1: Metastasis in 1 to 6 regional lymph nodes. Metastasis in 7 to 15 regional lymph nodes.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7298] "Stage III includes: IIIA (T2a/b, N2, M0); (T3, N1, M0); (T4, N0, M0).  IIIB: (T3, N2, M0).  N0: No regional lymph node metastasis. N1: Metastasis in 1 to 6 regional lymph nodes.  N2: Metastasis in 7 to 15 regional lymph nodes. T2a: Tumor invades muscularis propria.  T2b: Tumor invades subserosa. T3: Tumor penetrates serosa (visceral peritoneum) without invasion of adjacent structures. T4: Tumor invades adjacent structures.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [7299] "Cancer that has spread beyond the top layer of anal tissue and is larger than 2 centimeters (about 1 inch) but has not spread to nearby organs or lymph nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7300] "Stage III anal cancer is divided into stage IIIA and IIIB. Stage IIIA anal cancer has spread to the lymph nodes around the rectum or to nearby organs such as the vagina or bladder.  Stager IIIB cancer has spread to the lymph nodes in the middle of the abdomen or in the groin, or the cancer has spread to both nearby organs and the lymph nodes around the rectum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7301] "Cancer that has spread to nearby lymph nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7302] "Cancer has spread to structures near the lung; to the lymph nodes in the area that separates the two lungs(mediastinum); or to the lymph nodes on the other side of the chest or in the lower neck. Stage III is further divided into stage IIIA (usually can be resected which is sometimes treated with surgery) and stage IIIB (usually cannot be resected which is rarely treated with surgery)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7303] "A carcinoma originating from the apical lung. Most superior sulcus lung carcinomas are bronchogenic carcinomas. This carcinoma may be associated with Pancoast syndrome. Also known as Pancoast tumor. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7304] "Osteosarcoma localized or limited to a definite location."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [7305] "Osteosarcoma that has spread to a second site"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7306] "Stage IIIB breast cancer is defined by either of the following: (1) the cancer has spread to tissues near the breast (skin, chest wall, including the ribs and the muscles in the chest); (2) the cancer has spread to lymph nodes inside the chest wall along the breast bone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7307] "The reemergence of non small cell lung cancer after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7308] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7309] "Cancer that is found only in the pancreas itself or has started to spread to the tissues next to the pancreas (such as the small intestine, the stomach, or the bile duct)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7310] "Cancer that has spread to nearby organs such as the stomach, spleen, or colon but has not entered the lymph nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7311] "Cancer of the pancreas in which the cancer has spread to the lymph nodes near the pancreas. Cancer may have spread to nearby organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7312] "Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial tumor without invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7313] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7314] "Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. (AJCC 6th ed.) -2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7315] "Stage II includes IIA (T3, N0, M0) and IIB (T4, N0, M0). T3: Tumor invades through the muscularis propria into the subserosa, or into nonperitonealized pericolic or perirectal tissues. T4: Tumor directly invades other organs or structures, and/or perforates the visceral peritoneum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [7316] "Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7317] "Anal cancer with repeated appearances in the patient after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7318] "Stage 0 anal cancer corresponds to the following TNM grouping: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7319] "May be either of the following: (1) stage IA cancer affecting less than 10% of the skin's surface and appearing as red, dry, scaly patches; (2) stage IB cancer affecting 10% or more of the skin's surface and appearing as red, dry, scaly patches."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7320] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7321] "Stage II cutaneous T-cell lymphoma may be either of the following: (1) stage IIA, in which the skin has red, dry, scaly patches but no tumors, and lymph nodes are enlarged but do not contain cancer cells; (2) stage IIB, in which tumors are found on the skin, and lymph nodes are enlarged but do not contain cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7322] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7323] "Nearly all of the skin is red, dry, and scaly; lymph nodes are either normal or enlarged but do not contain cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [7324] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7325] "Stage IV cutaneous T-cell lymphoma may be either of the following: in stage IVA cancer, the skin is red, dry, and scaly, and the lymph nodes contain cancer cells; in stage IVB cancer, the skin is red, dry and scaly, cancer cells may be found in lymph nodes, and cancer has spread to other organs in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7326] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7327] "Cancer that has spread to nearby areas but is still inside the pelvis. In stage IIA cancer of the cervix, cancer has spread beyond the cervix to the upper two thirds of the vagina; in stage IIB, cancer has spread to the tissue around the cervix."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7328] "The reemerging of cervical carcinoma after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7329] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7330] "Ewing's sarcoma which has not spread from its initial site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7331] "Ewing's sarcoma which has spread from its initial site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7332] "Ewing's sarcoma which has recurred after treatment and/or remission. While initial complete responses are not uncommon, there is a fair chance of relapse as late as one to two decades after initial therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7333] "A malignant mesenchymal tumor composed of fibroblasts, and characterized by collagen production and a herringbone architectural pattern.  It is more commonly seen in middle-aged and older adults.  It usually affects the deep soft tissues of extremities, trunk, head and neck.  Adult fibrosarcomas may recur and metastasise to the lungs and bones. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7334] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7335] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7336] "A localized clonal (malignant) plasma cell infiltrate in the bone without peripheral blood involvement.  The most commonly affected bones are the vertebrae, ribs, skull, pelvis and femur.  X-rays examination reveals a solitary lytic lesion. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7337] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7338] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7339] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7340] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7341] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7342] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7343] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7344] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7345] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7346] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7347] "A tumor that is 7 centimeters (2.75 inches) or smaller."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7348] "Stage 2 includes T2 ,N0, M0.  T2: Tumor more than 7 cm in greatest dimension limited to the kidney.  N0: No regional lymph node metastases.  M0: No distant metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7349] "A reemergence of renal cell carcinoma after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7350] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7351] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7352] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7353] "Cancer that is found in one or both of the ovaries and has not spread."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7354] "Cancer that is found in one or both ovaries and/or has spread to one of more of the following: uterus, fallopian tubes, other body parts within the pelvis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7355] "Cancer is found in one or both ovaries and has spread to lymph nodes or to other body parts inside the abdomen (such as the surface of the liver or intestine)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7356] "Cancer is found in one or both ovaries and has spread outside the abdomen or has spread to the inside of the liver."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [7357] "The reemergence of ovarian epithelial cancer after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7358] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7359] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7360] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7361] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7362] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7363] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7364] "Cancer that is found in the kidney only and can be completely removed by surgery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7365] "Cancer has spread to tissue near the kidney, to blood vessels, or to the renal sinus (a part of the kidney through which blood and fluid enter and exit). The cancer can be completely removed by surgery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7366] "Cancer has spread to tissues near the kidney and cannot be completely removed by surgery. The cancer may have spread to blood vessels or organs near the kidney or throughout the abdomen. The cancer may also have spread to lymph nodes near the kidney."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7367] "Cancer has spread to organs further away from the kidney (such as the lungs, liver, bone, and brain)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7368] "Cancer cells are found in both kidneys."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7369] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7370] "Retinoblastoma restricted to local involvement."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7371] "Rai staging system. Stage 0 chronic lymphocytic leukemia: absolute lymphocytosis (>15,000 per cubic millimeter) without adenopathy, hepatosplenomegaly, anemia, or thrombocytopenia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7372] "Retinoblastoma that has spread beyond the eye e.g. to brain, soft tissue/bone, bone marrow."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7373] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7374] "Relatively few cancer cells have spread throughout the body. There may be no symptoms of disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7375] "Cancer in which a moderate number of cancer cells have spread throughout the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7376] "A relatively large number of cancer cells have spread throughout the body. There may be one or more of the following: 1) a decrease in the number of red blood cells, causing anemia; 2) the amount of calcium in the blood is very high, because the bones are being damaged; 3) more than three bone tumors (plasmacytomas) are found; or 4) high levels of M protein are found in the blood or urine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7377] "Cancer found in one lung and in nearby lymph nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [7378] "Cancer found in the vulva only or the space between the opening of the rectum and the vagina (perineum). The tumor is 2 centimeters (about 1 inch) or smaller."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7379] "Stage 0 includes: (Tis, N0, M0).  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7380] "Stage I includes: (T1, N0, M0).  T1: Tumor confined to vagina.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7381] "Stage 2: (T2, N0, M0). T2: Tumor invades paravaginal tissues but not to pelvic wall.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7382] "Stage 3 includes: (T1-3, N1, M0) and (T3, N0, M0). T3: Tumor extends to pelvic wall.  N0: No regional lymph node metastasis.  N1: Pelvic or inguinal lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7383] "Stage IVa includes: T4, Any N, M0. T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4.). M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7384] "The reemergence of vaginal cancer after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7385] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7386] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7387] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7388] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7389] "The reemergence of malignant mesothelioma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7390] "Stage I includes: (T1, N0, M0).  T1: Tumor invades subepithelial connective tissue.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7391] "Stage II includes: (T1, N1, M0); (T2, N0, M0); (T2, N1, M0).  T1: Tumor invades subepithelial connective tissue.  N0: No regional lymph node metastasis.  N1: Metastasis in a single superficial, inguinal lymph node.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7392] "Stage III includes: (T1, N2, M0); (T2, N2, M0); (T3, N0, M0); (T3, N1, M0); (T3, N2, M0).  T1: Tumor invades subepithelial connective tissue.  T2: Tumor invades corpus spongiosum or cavernosum.  T3: Tumor invades urethra or prostate.  N0: No regional lymph node metastasis.  N1: Metastasis in single superficial, inguinal lymph node. N2: Metastasis in multiple or bilateral superficial inguinal lymph nodes.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [7393] "A carcinoma of the penis that reappears after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7394] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7395] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7396] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7397] "Stage I chronic lymphocytic leukemia: absolute lymphocytosis with lymphadenopathy without hepatosplenomegaly, anemia, or thrombocytopenia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7398] "Stage II chronic lymphocytic leukemia: absolute lymphocytosis with either hepatomegaly or splenomegaly, with or without lymphadenopathy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7399] "Stage III chronic lymphocytic leukemia: absolute lymphocytosis and anemia (hemoglobin <11 g/dL) with or without lymphadenopathy, hepatomegaly, or splenomegaly."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7400] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7401] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7402] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7403] "Osteosarcoma reappearing after a remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7404] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7405] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7406] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7407] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7408] "Chronic lymphocytic lymphoma that is resistant to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7409] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7410] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7411] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7412] "Cancer that has spread to the tissues around the gallbladder (such as the liver, stomach, pancreas, intestine, or lymph nodes in the area) and cannot be surgically removed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [7413] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7414] "Bile duct cancer not amenable to surgical removal"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7415] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7416] "The reemergence of small intestine carcinoma after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [7417] "Stage 0 includes Ta, Tis, N0, M0 Ta: Non-invasive papillary carcinoma.  Tis: Carcinoma in situ: \"flat tumor\".  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7418] "Cancer that has spread into the inner lining of the bladder but not to the muscular wall of the bladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7419] "Cancer that has spread to the muscular wall of the bladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7420] "Cancer cells have spread throughout the muscular wall of the bladder, to the layer of tissue surrounding the bladder, and/or to the nearby reproductive organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7421] "The reemergence of bladder cancer after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7422] "Cancer cells have spread to the wall of the abdomen or pelvis or to nearby lymph nodes, or it has spread to lymph nodes and other parts of the body far from the bladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [7423] "Cancer that is found in the testicle only or has spread into the scrotum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [7424] "Prostate cancer reemerging after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7425] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7426] "A malignant thymoma that extends beyond the capsule and infiltrates the surrounding tissues.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7427] "Reemergence of malignant thymoma after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7428] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7429] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7430] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7431] "A benign (adenoma) or malignant (carcinoma), corticotropin secreting pituitary tumor.  It can be associated with Cushing's syndrome. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [7432] "Benign and malignant pituitary neoplasms that secrete prolactin, leading to increased serum levels of this hormone. The most common type is Prolactin producing adenoma, prolactinoma which is related to Multiple Endocrine Neoplasia I as well as McCune Albright syndrome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7433] "A pituitary adenoma which produces somatotrophin. It can be associated with gigantism and acromegaly."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7434] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7435] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7436] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7437] "A pituitary adenoma which produces thyroid stimulating hormone It can be associated with hyperthyroidism. DeVita et al., CANCER, 4th edition."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7438] "Cancer found in the outer layer of the skin (epidermis), the upper part of the inner layer of skin (dermis), or both but not in nearby lymph nodes. The tumor is no thicker than 1.5 millimeters (about 1/16 of an inch)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [7439] "Stage II includes: IIA (T2b, N0, M0); (T3a, N0, M0); IIB (T3b, N0, M0); (T4a, N0, M0); IIC (T4b, N0, M0).  T2b: Melanoma 1.01 - 2.0mm in thickness, with ulceration.  T3a: Melanoma 2.01 - 4.0mm in thickness, no ulceration.  T3b: Melanoma 2.01 - 4.0mm in thickness, with ulceration.  T4a: Melanoma is greater than 4.0 mm in thickness, no ulceration.  T4b: Melanoma is greater than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastasis.  M0: No distant metastasis. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7440] "Stage III includes: (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0).  N1: Metastasis in one lymph node.  N2: Metastasis in two to three regional lymph nodes or intralymphatic regional metastasis without nodal metastases.  N3: Metastasis in four or more regional nodes, or matted metastatic nodes, or in-transit metastasis or satellite(s) with metastasis in regional node(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7441] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7442] "Stage II includes: IIA (T2a, N0, M0); IIB (T1, N1, M0), (T2, N1, M0), (T2a, N1, M0); (T2b, N0, M0); (T2b, N0, M0); (T2b, N1, M0).  T2: Tumor extends to soft tissues.  T2a: Tumor extends to the oropharynx and/or nasal cavity without parapharyngeal extension.  T2b: Any tumor with parapharyngeal extension.  N1: Unilateral metastasis in lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7443] "The two most severe classes of cardiac dysfunction according to a classification system developed by the New York Heart Association to grade cardiovascular function and disability. These classes are defined as follows: Class III - patients with cardiac disease producing marked limitation of activity: comfortable at rest. Less than ordinary physical activity causes symptoms. Class IV - patients with cardiac disease resulting in inability to carry on any physical activity without discomfort. Symptoms may be present even at rest. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7444] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7445] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7446] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7447] "The reemergence of salivary gland cancer after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7448] "A carcinoma arising in the liver or intrahepatic bile duct.  The main subtypes are hepatocellular carcinoma (hepatoma) and cholangiocarcinoma. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7449] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7450] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7451] "An angiocentric and angiodestructive lymphoproliferative disease involving extranodal sites, comprised of Epstein-Barr virus (EBV)-positive B-cells admixed with reactive T-cells.  The most common site of involvement is the lung.  Other common sites of involvement include brain, kidney, liver, and skin.  Morphologically, three grades are recognized: grade I, II, and III.  Grade III lymphomatoid granulomatosis should be approached clinically as a subtype of diffuse large B-cell lymphoma. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7452] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7453] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7454] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7455] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7456] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7457] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7458] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7459] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7460] "Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7461] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7462] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7463] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7464] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7465] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7466] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7467] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7468] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7469] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7470] "An infiltrating lobular adenocarcinoma.  The malignant cells lack cohesion and are aranged individually or in a linear manner (Indian files), or as narrow trabeculae within the stroma.  The malignant cells are usually smaller than those of ductal carcinoma, are less pleomorphic, and have fewer mitotic figures. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7471] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7472] "The only TdT negative ALL is L3 (Burkitt's)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [7473] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7474] "The only TdT negative ALL is L3 (Burkitt's)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [7475] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7476] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7477] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7478] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7479] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7480] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7481] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7482] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7483] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7484] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7485] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7486] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7487] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7488] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7489] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7490] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7491] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7492] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7493] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7494] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7495] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7496] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7497] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7498] "Endometrioid adenocarcinoma comprises 10% to 25% of all primary ovarian carcinomas.  Grossly, endometrioid carcinoma may present as a cystic or solid mass.  Microscopically, the tumor resembles greatly the appearance of the ordinary type of endometrial adenocarcinoma.  As a group, endometrioid carcinoma has a prognosis twice as good as that of serous or mucinous carcinoma. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7499] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7500] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7501] "Small cell carcinoma originating in the cervix"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7502] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7503] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7504] "Intraocular Melanoma is derived from melanocytes of the uveal tract.  This tumor is the most common primary intraocular tumor in the United States and Western Europe.  Similar to melanoma of the skin it is rare in Africa and Asia.  Diagnostic procedures include ophthalmoscopic exam, fluorescein angiograph and ultrasound.  Treatment includes: surgical excision of the eye, iridocyclectomy and tumor resection.  Recently treatment as also included radiotherapy or photo coagulation.  Classification of uveal melanomas recognizes four cell types within these tumors. Spindle A and B cells are included in this classification. - 2002"                                                                                                                                                                                                                                                                                                                                            
 [7505] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7506] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7507] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7508] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7509] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7510] "Squamous cell carcinoma (keratinizing) of the nasopharynx is defined as a carcinoma having squamous differentiation in the form of intercellular bridges or keratinization over most of its extend (Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999). --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7511] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7512] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7513] "This is not a distinct clinicopathological entity, but it may arise from other types of renal cell carcinomas. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7515] "Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated carcinoma. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7516] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7517] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7518] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7519] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7522] "A delta cell somatostatin producing endocrine neoplasm of the pancreas.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7523] "Pituitary adenomas represent approximately 10% of intracranial neoplasms.  Pituitary adenomas can be classified on the basis of their anatomical, histological, or functional characteristics.  This is a rare cause of hyperthyroidism mediated by a thyroid stimulating hormone producing tumor. - 2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [7524] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7526] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7527] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7529] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7531] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7534] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7535] "Undifferentiated nasopharyngeal carcinoma (lymphoepithelioma) is defined as a carcinoma with cytologically uniform cells with ovoid vesicular nuclei, prominent nucleoli, and indistinct cell borders resulting in a syncytial pattern.  Usually, an inflammatory infiltrate rich in mature lymphocytes and occasionally eosinophiles is also present (Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999). --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7536] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7537] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7538] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7539] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7540] "A high-grade endometrial adenocarcinoma characterized by the presence of large neoplastic cells that display at least focal cytoplasmic clearing.  The neoplastic cells form papillary, glandular, or sheet-like structures. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7541] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7542] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7543] "Cancer that has not spread to the lymph nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7544] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7545] "Cancer that is no larger than 2 centimeters (about 1 inch) and has not spread to nearby lymph nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7546] "Cancer that is larger than 2 centimeters (about 1 inch) but smaller than 4 centimeters (about 2 inches) and has not spread to lymph nodes in the area."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7547] "Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [7548] "The cancer has spread to tissues around the lip and oral cavity (the lymph nodes in the area may contain cancer); the cancer is any size and has spread to more than one lymph node on the same side of the neck as the cancer, to lymph nodes on one or both sides of the neck, or to any lymph node that is larger than 6 centimeters (larger than 2 inches); or the cancer has spread to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7549] "The reemergence of lip and/or oral cavity cancer after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7550] "Stage I includes: T1, N0, M0.  T1: Tumor limited to one subsite of the hypopharynx and 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7551] "Cancer that involves more than one area of the hypopharynx or is between 2 and 4 centimeters (between 0.75 and 1.5 inches)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7552] "Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0) (T3, N1, M0).  T3: Tumor more than 4 cm in greatest dimension or with fixation of hemilarynx.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 6th ed.)- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7553] "Cancer that is only in the area where it started and has not spread to nearby lymph nodes or other parts of the body. The exact definition of stage I depends on whether the cancer started in the supraglottis (cancer in only one area of the supraglottis, and the vocal cords can move normally); the glottis (cancer in only the vocal cords, and the vocal cords can move normally); or the subglottis (cancer that has not spread outside the subglottis)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7554] "Cancer that is found in the larynx only and has not spread to lymph nodes in the area or to other parts of the body. The exact definition of stage II depends on whether the cancer started in the supraglottis (cancer is in more than one area of the supraglottis, but the vocal cords can move normally); the glottis (cancer has spread to the supraglottis, the subglottis, or both, and the vocal cords may not be able to move normally); or the subglottis (cancer has spread to the vocal cords, which may not be able to move normally)."                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [7555] "Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: (Supraglottis) Tumor limited to larynx with vocal cord fixation and/or invades any of the following: postcricoid area, pre-epiglottic tissues, paraglottic space, and/or minor thyroid cartilage erosion (e.g., inner cortex).  (Glottis) Tumor limited to the larynx with vocal cord fixation and/or invades paraglottic space, and or minor thyroid cartilage erosion (e.g., inner cortex).  (Subglottis)Tumor limited to larynx with vocal cord fixation.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, more than 3cm but not more than 6cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                  
 [7556] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7557] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7558] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7559] "Cancer that is no larger than 2 centimeters (about 0.75 inch) and is confined to the oropharynx."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7560] "Stage II includes: T2, N0, M0.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7561] "Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N2, M0).  T3: Tumor more than 4 cm in greatest dimension.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6cm in greatest dimension.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7562] "The reemergence of oropharyngeal cancer after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7563] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7564] "A malignant neoplasm of the ovary.  Overall, sex cord-stromal tumors comprise about 5% of all ovarian neoplasms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7565] "(fo-LIK-yu-ler) Cancer that develops from cells in the follicular areas of the thyroid. One of the slow-growing, highly treatable types of thyroid cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7566] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7568] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7569] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7570] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7571] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7572] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7573] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7574] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7575] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7576] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7577] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7578] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7579] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7580] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7581] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7582] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7583] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7584] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7585] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7586] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7587] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7588] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7589] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7590] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7591] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7592] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7593] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7594] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7595] "Stage II ovarian germ cell tumor is growth involving one or both ovaries with pelvic extension.  Stage IIA: extension and/or metastases to the uterus and/or tubes.  Stage IIB: extension to other pelvic tissues.  Stage IIC: tumor either stage IIA or stage IIB, but with tumor on the surface of one or both ovaries; or with capsule(s) ruptured; or with ascites present containing malignant cells or with positive peritoneal washings."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7596] "Stage IIIA: tumor grossly limited to the true pelvis with negative nodes but with histologically confirmed microscopic seeding of abdominal peritoneal surfaces.  Stage IIIB: tumor of one or both ovaries with histologically confirmed implants of abdominal peritoneal surfaces, none exceeding 2 cm in diameter; negative nodes.  Stage IIIC: abdominal implants greater than 2 cm in diameter and/or positive retroperitoneal or inguinal nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7597] "Stage IV ovarian germ cell tumor is growth involving one or both ovaries with distant metastasis. If pleural effusion is present, there must be positive cytologic test results to allot a case to stage IV. Parenchymal liver metastasis equals stage IV."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7598] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7599] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7600] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7601] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7602] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7603] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7604] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7605] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7607] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7608] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7609] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7610] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7611] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7612] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7613] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7614] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7615] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7616] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7617] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7618] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7619] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7620] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7621] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7622] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7623] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7624] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7625] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7626] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7627] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7628] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7629] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7630] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7631] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7632] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7633] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7634] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7635] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7636] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7637] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7638] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7639] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7640] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7641] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7642] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7643] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7644] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7645] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7646] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7647] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7648] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7649] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7650] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7651] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7652] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7653] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7654] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7655] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7656] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7657] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7658] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7659] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7660] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7661] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7662] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7663] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7664] "The reemergence of B-cell small lymphocytic lymphoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7665] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7666] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7667] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7668] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7669] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7670] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7671] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7672] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7673] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7674] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7675] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7676] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7677] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7678] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7679] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7680] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7681] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7682] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7683] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7684] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7685] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7686] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7687] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7688] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7689] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7690] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7691] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7692] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7693] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7694] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7695] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7696] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7697] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7698] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7699] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7700] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7701] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7702] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7703] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7704] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7705] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7706] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7707] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7708] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7709] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7710] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7711] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7712] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7713] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7714] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7715] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7716] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7717] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7718] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7719] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7720] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7721] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7722] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7723] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7724] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7725] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7726] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7727] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7728] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7729] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7730] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7731] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7732] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7733] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7734] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7735] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7736] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7737] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7738] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7739] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7740] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7741] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7742] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7743] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7744] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7745] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7746] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7747] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7748] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7749] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7750] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7751] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7752] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7753] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7754] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7755] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7756] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7757] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7758] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7759] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7760] "The reemergence of adult T-cell lymphoma/leukaemia after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7761] "An acute myeloid leukemia arising as a result of the mutagenic effect of alkylating agents and/or ionizing radiation.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7762] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7763] "Reemergence of transitional cell cancer of the renal pelvis and ureter after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [7764] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7765] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7766] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7767] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7768] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7769] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7770] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7771] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7772] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7773] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7774] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7775] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7776] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7777] "A tumor of mixed cell type with astrocytic components as well as ependymomas components."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7778] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7779] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7780] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7781] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7782] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7783] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7784] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7785] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7786] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7787] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7788] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7789] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7790] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7791] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7792] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7793] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7794] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7795] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7796] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7797] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7798] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7799] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7800] "Pancreatic adenocarcinoma is an adenocarcinoma which arises from the exocrine pancreas.  Ductal adenocarcinoma and its variants are the most common types of pancreatic adenocarcinoma. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [7801] "A overgrowth of epithelial tissue in the respiratory tree without malignant characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [7802] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7803] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7804] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7805] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7806] "(dez-mo-PLAS-tik...) A rare, aggressive cancer that usually affects young males and usually is located in the abdomen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7807] "Disorder in which veins are partially or completely obstructed or the blood flow through the veins is suboptimal.--2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7808] "An immune response to a person's tumor cells by immune cells present in a donor's transplanted tissue, such as bone marrow or peripheral blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7809] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7810] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7811] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7812] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7813] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7814] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7815] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7816] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7817] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7818] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7819] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7820] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7821] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7822] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7823] "Colloid cysts i.e. cysts filled with gelatinous material, in the central nervous system often are found in the third ventricle. Due to their location, chronic or intermittent hydrocephalus can result. Case reports of sudden death due to acute obstructive hydrocephalus are in the literature. Colloid cysts are benign lesions that should be considered for neurosurgical resection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7824] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7825] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7826] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7827] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7828] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7829] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7830] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7831] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7832] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7833] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7834] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7835] "(SKWAY-mus in-tra-eh-pih-THEEL-ee-ul LEE-zhun) SIL. A general term for the abnormal growth of squamous cells on the surface of the cervix. The changes in the cells are described as low grade or high grade, depending on how much of the cervix is affected and how abnormal the cells appear."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7836] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7837] "HSIL. A precancerous condition in which the cells of the uterine cervix are moderately or severely abnormal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [7838] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7839] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7840] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7841] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7842] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7843] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7844] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7845] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7846] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7847] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7848] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7849] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7850] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7851] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7852] "An abnormality often noted in pap smears.  Koilocytotic atypia affects the squamous epithelium of the transformation zone. The cells involved show cytoplasmic vacuolization that might be related to their ability to store glycogen. The most characteristic feature of this condition is the peripheral cytoplasmic condensation associated with an increase of tonofilaments. (from Acta Cytol 1981;25:377-82 )"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [7853] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7854] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7855] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7856] "(hy-per-PLAY-zha) A benign (noncancerous) condition in which cells have abnormal features and are increased in number."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7857] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7858] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7859] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7860] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7861] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7862] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7863] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7864] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7865] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7866] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7867] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7868] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7869] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7870] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7871] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7872] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7873] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7874] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7875] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7876] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7877] "An aggressive cancer that usually affects the uterus/endometrium, peritoneum, or ovary."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7878] "A morphologic variant of malignant fibrous histiocytoma, characterized by osteoclast-like giant cells and cellular pleomorphism. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [7879] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7880] "A rare malignant tumor of the choroid plexus (comprises less than twenty five percent of choroid plexus tumors) which is more commonly found in children then adults.  Interestingly, this tumor is most often supratentorial in children and infratentorial in adults.  The presentation is referable to symptoms of increased intracranial pressure in all ages.  This tumor is easily detected on magnetic resonance imaging.  Neonatal diagnosis via ultrasonography has been reported.  The initial goal for treatment is gross total resection.  Once a choroid plexus carcinoma has been diagnosed, one would have to image the entire neuraxis due to this tumors common tendency to spread.  Adjunctive therapy is usually given: radiation therapy can be used for persons three years of age or greater; chemotherapy can be utilized at any age.(Kaye, Laws Brain Tumors Churchill Livingstone 1995)"                                                                                   
 [7881] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7882] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7884] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7885] "Abnormal growth of hormone producing cells in the pituitary gland. There is no way to predict the degree of invasiveness. The presence of microinvasion does not accurately portend malignant potential. Secretory pituitary adenomas are more common than non-secretory adenomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7886] "Regrowth of benign and malignant childhood cerebellar astrocytomas that have previously been subjected to surgical resection and less frequently other forms of therapy such as radiation or chemotherapy.  Recurrence of benign tumors (e.g., (pilocytic astrocytoma) may respond to a second surgical procedure.  (KEV 8-7-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7887] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7888] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7889] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7891] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7892] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7893] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7894] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7895] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7896] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7897] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7898] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7899] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7900] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7901] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7902] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7903] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7906] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7907] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7908] "Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7910] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7911] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7912] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7913] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7914] "Dysplastic Gangliocytoma of the Cerebellum (WHO grade I), also called Lhermitte-Duclos disease, is a benign cerebellar mass, which occurs in young adults and is composed of dysplastic ganglion cells.  It is the major CNS manifestation of Cowden Disease, an autosomal dominant condition that causes a variety of hamartomas and neoplasms.(Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [7915] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7916] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7917] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7918] "Stage 0 includes: Tis, N0, M0.  Tis: Melanoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7919] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7920] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7922] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7923] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7924] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7927] "(MY-krow-kal-si-fi-KAY-shunz) Tiny deposits of calcium in the breast that cannot be felt but can be detected on a mammogram. A cluster of these very small specks of calcium may indicate that cancer is present."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7928] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7929] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7932] "Abnormal secretion of renin in conjunction with neoplastic growth occurring anywhere in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7933] "Abnormal secretion of growth hormone in conjunction with neoplastic growth occurring anywhere in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7934] "Abnormal secretion of prolactin in conjunction with neoplastic growth occurring anywhere in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [7935] "Abnormal secretion of aldosterone in conjunction with neoplastic growth occurring anywhere in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7936] "Abnormal secretion of calcitonin in conjunction with neoplastic growth occurring anywhere in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7937] "Abnormal secretion of chorionic gonadotropin in conjunction with neoplastic growth occurring anywhere in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7938] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7939] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7940] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7941] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7942] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7943] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7944] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7945] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7946] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7948] "An aggressive, extranodal, and systemic mature T-cell non-Hodgkin's lymphoma, derived from cytotoxic T-cells, usually of gamma/delta T-cell receptor type.  Patients usually manifest marked thrombocytopenia, often associated with anemia and leukocytosis. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7949] "An acute myeloid leukemia (AML) in which the blasts do not show evidence of myeloid differentiation by morphology and conventional cytochemistry.  The myeloid origin of the blasts is demonstrated by immunohistochemistry and/or electron microscopic studies.  The patients present with anemia, neutropenia, and thrombocytopenia.  The prognosis is usually poor.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7950] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7951] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7952] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7953] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7954] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7955] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7956] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7957] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7958] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7960] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7961] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7963] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7965] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7966] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7968] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7969] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7970] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7971] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [7972] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7973] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7974] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7975] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7976] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7977] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7979] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7980] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7981] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7982] "An inherited disorder in which affected individuals have a higher-than-normal chance of developing colon cancer and certain other types of cancer, usually before the age of 60.  Also called hereditary nonpolyposis colon cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [7983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7984] "1.  Familial embryonal neoplasm derived from nephrogenic blastemal cells.  Several lines of differentiation, including blastemal, stromal and epithelial, are usually expressed.  Comprises approximately 1% of Wilms' tumors.  (AFIP fascicle version 2.0 mo011000)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [7985] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7986] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7988] "Cancer that occurs in both paired organs, such as both breasts or both ovaries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7989] "(glee-O-ma) A tumor located in the part of the brain that connects to the spinal cord (the brain stem). It may grow rapidly or slowly, depending on the grade of the tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [7990] "A slowly progressing disease in which too many immature white blood cells (called lymphoblasts) are found in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [7991] "Disease that cannot be measured directly by the size of the tumor but can be evaluated by other methods specific to a particular clinical trial."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [7992] "Lymphomas that tend to grow and spread slowly, including chronic lymphocytic lymphoma and follicular small cleaved cell lymphoma. Also called low-grade lymphomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7993] "Cancer that has spread beyond the layer of tissue in which it developed and is growing into surrounding, healthy tissues. Also called infiltrating cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [7994] "A tumor that involves the tissues that cover the brain and spinal cord."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [7995] "A tumor that can be accurately measured in size. This information can be used to judge response to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [7996] "Lymph nodes in the area of the armpit (axilla) to which cancer has spread. This spread is determined by surgically removing some of the lymph nodes and examining them under a microscope to see whether cancer cells are present."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [7997] "The original tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [7998] "Cancer that is increasing in scope or severity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [7999] "Cancer that has not responded to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8001] "Stage I includes: T1, T2 and NO, MO.  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis (AJCC 6th ed.)-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8002] "Cancer that has spread beyond the colon/rectum but not to the lymph nodes. Also called Dukes B colorectal cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8003] "Stage Group III is subdivided into IIIA (T1-2, N1, M0), IIIB (T3-4, N1, M0) or IIIC (any T, N2 M0).  T1: Tumor invades the submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into the subserosa or into non-peritonealized pericolic or perirectal tissues.  T4: Tumor directly invades other organs or structures, and/or perforates visceral peritoneum.  N1: Metastasis in 1 to 3 regional lymph nodes N2: Metastasis in 4 or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8004] "Cancer cells have spread to organs and lymph nodes in other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8005] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8006] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8007] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8008] "Cancer found in only one lymph node area or one area or organ outside the lymph nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8009] "Cancer that is found in two or more lymph node areas on the same side of the diaphragm (the muscle under the lungs that helps breathing). Cancer is found in only one area or organ outside the lymph nodes and in the lymph nodes around it. Other lymph node areas on the same side of the diaphragm may also have cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8010] "Cancer is found in lymph node areas on both sides of the diaphragm. The cancer may also have spread to an area or organ near the lymph node areas, to the spleen, or both."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8011] "Cancer has spread to more than one organ or organs outside the lymph system. Cancer cells may be found in the lymph nodes near these organs. Cancer has spread to only one organ outside the lymph system, but lymph nodes far away from that organ are involved."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8012] "Cancer that has spread only to nearby tissues or lymph nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8013] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8014] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8015] "The spread of the cancer to the neck.  This may be from a primary cancer of the neck, or from a cancer at a distant site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8016] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8017] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8018] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8019] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8020] "The tumor has spread to nearby tissues and lymph nodes of the neck and may have spread to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8021] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8022] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8023] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8024] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8025] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8026] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8027] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8028] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8029] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8030] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8031] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8032] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8033] "The spread of the cancer to the nervous system.  This may be from a primary nervous system cancer, or from a cancer at a distant site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8034] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8035] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8036] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8037] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8038] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8039] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8040] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8041] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8042] "Abnormal malignant growth of the paraganglion cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8043] "Erythroleukemia that is responding to therapy, i.e. It is not progressing and possibly regressing"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8044] "A primary or metastatic malignant tumor involving the male reproductive system. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8045] "A rare cancer of melanocytes (cells that produce thepigment melanin) found in the eye.  Also called intraocular melanoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8046] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8047] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8048] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8049] "A case in which cancer cells are found in the body, but the place where the cells first started growing (the origin or primary site) cannot be determined."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8050] "A rare, slow-growing tumor of the eye."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8051] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8052] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8053] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8054] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8055] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8056] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8057] "A myelodysplastic syndrome characterized by bi-cytopenia or pancytopenia and dysplastic changes in 10% or more of the cells in two or more of the myeloid cell lines.  A minority of cases progress to acute myeloid leukemia.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8058] "Cancer of the pancreas in which the cancer has spread to distant organs (such as the liver or lungs)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8059] "A malignant neoplasm which is confined to a specific anatomic site and has not been spread. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8060] "Cancer that has spread from the surface of the cervix to tissue deeper in the cervix or to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8061] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8062] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8063] "Cancer in which the cells look somewhat different from normal cells. The cancer is larger than 5 centimeters (about 2 inches) and has not spread to lymph nodes or other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8064] "The cancer cells look somewhat different from normal cells. The cancer is larger than 5 centimeters (about 2 inches) and has not spread to lymph nodes or other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8065] "The cancer cells look very different from normal cells. The cancer is smaller than 5 centimeters (about 2 inches) and has not spread to lymph nodes or other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8066] "Cancer in which the cells look very much like normal cells. The cancer is smaller than 5 centimeters (about 2 inches) and has not spread to lymph nodes or other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8067] "The cancer cells look very different from normal cells. The cancer is larger than 5 centimeters (about 2 inches) and has not spread to lymph nodes or other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8068] "The cancer cells look very different from normal cells. The cancer is larger than 5 centimeters (about 2 inches) but has not spread to lymph nodes or other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8069] "The cancer has spread to lymph nodes in the area or other parts of the body (such as the lungs, head, or neck)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8070] "Growths that protrude from a mucous membrane. Precancerous polyps may (or are likely to) become cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8071] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8072] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8073] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8074] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8075] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8076] "A usually terminal event in the clinical course of lymphomas.  The term indicates the presence of atypical, clonal (malignant) lymphocytes (lymphoma cells) in the peripheral blood. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8077] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8078] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8079] "Abnormal growth of the cells behind the orbit"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8080] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8081] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8082] "A melanoma affecting the retinal portion of the eye. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8083] "A benign, slow-growing tumor composed of cells that demonstrate both epithelial and mesenchymal differentiation. It is the most common neoplasm of salivary gland origin, and mostly occurs in the parotid gland. The average age of patients has been reported to be 43 years; women are more often affected than men. The malignant change rate has been estimated to be 6%. The malignant counterpart is carcinoma ex pleomorphic adenoma. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8084] "A papillary tumor originating in the renal pelvis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8085] "The reemergence of Waldenstrom's macroglobulinaemia after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8086] "Abnormal malignant growth of the tissues that comprise the spinal meninges: pia, arachnoid, dura."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8087] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8088] "The reemergence of inflammatory carcinoma of the breast after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8089] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8090] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8091] "The spread of the cancer to and establishment in the adrenals"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8092] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8093] "A myeloid sarcoma that is responding to therapy, i.e. is not progressing and possibly regressing.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8094] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8095] "The spread of a neoplasm from a primary site to an unspecified organ in the abdominal cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8096] "Chronic myelomonocytic leukaemia not growing; responding to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8097] "Pure erythroid leukemia that is responding to therapy, i.e. It is not progressing and possibly regressing"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8098] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8099] "The reemergence of colorectal cancer after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8100] "T4,N2,MO (from PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8101] "Esophageal adenocarcinoma that reappears after treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8102] "Stage 2 includes T2 or T3, N0, M0 and T1 or T2, N1, M0.  T2: Tumor invades muscularis propria.  T3: Tumor invades adventitia.  N0: No regional lymph node metastasis; N1: Regional lymph node metastasis; M0 No distant metastasis.(AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8103] "Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.)-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8104] "Stage 1 includes T1, N0, M0.  T1: Tumor invades lamina propria or submucosa; N0: No regional lymph node metastasis; M0: No distance metastasis. (AJCC 6th Edition)-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8105] "Stage 3 includes T3,N1,M0/T4,anyN,M0. T4: Tumor invades adjacent structures (from PDQ)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8106] "Stage 4 includes anyT, anyN, M1or M1a or M1b.  M1: Distant metastasis. Tumors of the lower thoracic esophagus.  M1a: Metastasis in celiac lymph nodes. M1b: Other distant metastasis. Tumors of the mid-thoracic esophagus.  M1a :Not applicable.  M1b: Nonregional lymph nodes and/or other distant metastasis.  Tumors of the upper thoracic esophagus.  M1a: Metastasis in cervical nodes.  M1b: Other distant metastasis (from PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8107] "An esophageal squamous cell carcinoma which has reappeared after a period of remission or after presumed treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8108] "The reemergence of rectosigmoid cancer after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8109] "Stage 3 includes anyT,N1,N2,M0, N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes (PDQ)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8110] "Stage 4 includes anyT, anyN, M1.  M1:Distant metastasis"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8111] "Carcinoma capable of spreading which has originated in the small intestine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8112] "Carcinoma of the small intestine not amendable to resection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8113] "Carcinoma of the small intestine amendable to resection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8114] "Bile duct cancer amenable to surgical removal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8115] "Hepatoblastoma not amenable to surgical removal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8116] "Hepatoblastoma amenable to surgical removal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8117] "The reemergence of hepatoblastoma after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8118] "The most frequent type of acute lymphoblastic leukemia.  Approximately 75% of cases occur in children under six years of age.  This is a good prognosis leukemia.  In the pediatric age group the complete remission rate is approximately 95% and the disease free survival rate is 70%.  Approximately 80% of children appear to be cured.  In the adult age group the complete remission rate is 60-85%.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8119] "The reemergence of chronic lymphocytic leukaemia after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8120] "Stage IV chronic lymphocytic leukemia: absolute lymphocytosis and thrombocytopenia (<100,000 per cubic millimeter) with or without lymphadenopathy, hepatomegaly, splenomegaly, or anemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8121] "A rare, highly aggressive, Epstein-Barr virus-associated leukemia/lymphoma that affects primarily teenagers and young adults.  It is characterized by the systemic proliferation of NK cells in the peripheral blood, bone marrow, liver, and spleen.--2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8122] "A myelodysplastic syndrome characterized by neutropenia or thrombocytopenia and dysplasia restricted to neutrophil or megakaryocytic cell lines.  The blasts in the bone marrow and blood are not increased.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8123] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8124] "Hodgkin's disease lymphocyte depletion resistant to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8125] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8126] "Waldenstrom's macroglobulinaemia resistant to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8127] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8128] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8129] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8130] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8131] "Adult T-cell lymphoma/leukaemia that is resistant to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8132] "Anaplastic large cell lymphoma t-and null cell types resistant to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8133] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8134] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8135] "Ann Arbor Classification. Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8136] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8137] "The reemergence of T-cell lymphoma after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8138] "T-cell non-Hodgkin's lymphoma resistant to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8139] "Stage I NHL means involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8140] "Stage II NHL means involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8141] "Stage III NHL means involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8142] "Stage IV NHL means disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8143] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8144] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8145] "Angioimmunoblastic T-cell lymphoma resistant to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8146] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8147] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8148] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8149] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s).  Any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8150] "The reemergence of angioimmunoblastic T-cell lymphoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8151] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8152] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8153] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8154] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8155] "Intestinal T-cell lymphoma that is resistant to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8156] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8157] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8158] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8159] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8160] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8161] "Mycosis fungoides resistant to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8162] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8163] "Peripheral T-cell lymphoma unspecified resistant to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8164] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8165] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8166] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8167] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8168] "A neoplasm of lymphoblasts committed to the T-cell lineage, typically composed of small to medium-sized blast cells.  When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is precursor T lymphoblastic leukemia (T-cell acute lymphoblastic leukemia).  When it involves nodal or extranodal sites it is T- lymphoblastic lymphoma. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8169] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8170] "Precursor T-lymphoblastic lymphoma/leukemia resistant to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8171] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (Rare in Hodgkin lymphoma). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8172] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in a with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8173] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8174] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, or nodular involvement of the lungs(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8175] "A non-Hodgkin's lymphoma which does not respond to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8176] "The reemergence of non-Hodgkin's lymphoma transformed after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8177] "A malignant mesothelioma extensively involving the pericardium. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8178] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8179] "The reemergence of malignant peritoneal mesothelioma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8180] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8181] "The reemergence of pleural malignant mesothelioma after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8182] "A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed) This concept specifically states that the tumor has metastasized from its original site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8183] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8184] "A rare malignant sarcoma that is believed to have its origin in smooth muscle derived pericytes without evidence of metastases"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8185] "Melanoma is a malignant tumor of melanocytes, cells that are derived from the neural crest. Although most melanomas arise in the skin, they also may arise from mucosal surfaces or at other sites to which neural crest cells migrate. (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8186] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8187] "Retinoblastoma involving both eyes. This occurs in the majority of patients with the inherited variant. A minority of patient with bilateral retinoblastoma were found to have involvement of the pineal gland as well."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8188] "A retinoblastoma that only involves a single eye."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8189] "A primary renal tumor notable for clusters of acidophilic tumor cells separated by vascular septa. It can be seen concurrent with traditional Wilms tumor.  This tumor is known to metastasize to lung and brain. It is associated, in the literature, with a slight male predominance. (Pizzo and Poplack, Principles and practice of pediatric oncology, 3rd edition.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8190] "Abnormal malignant growth of cells in the ureter (upper urinary tract) without spread to any other region."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8191] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8192] "Malignant neoplasms made of of squamous epithelial cells in the endometrium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8193] "Stage I includes: (T1, N0, M0); IA (T1a, N0, M0); IB (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor limited to the fallopian tube(s).  T1a: Tumor limited to one tube, without pentrating the serosal surface; no ascites.  T1b: Tumor limited to both tubes, without penetrating the serosal surface; no ascites.  T1c: Tumor limited to one or both tubes with extension onto or through the tubal serosa, or with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8194] "Stage II includes: (T2, N0, M0); IIA: (T2a, N0, M0); IIB (T2b, N0, M0); IIC (T2c, N0, M0).  T2: Tumor involves one or both fallopian tubes with pelvic extension.  T2a: Extension and/or metastasis to the uterus and/or ovaries.  T2b: Extension to other pelvic structures.  T2c: Pelvic extension with malignant cells or ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8195] "Stage III includes: (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c, N0, M0).  T3: Tumor involves one or both fallopian tubes, with peritoneal implants outside the pelvis.  T3a: Microscopic peritoneal metastasis outside the pelvis.  T3b: Macroscopic peritoneal metastasis outside the pelvis 2cm or less in greatest dimension.  T3c: Peritoneal metastasis more than 2cm in diameter. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8196] "Stage I includes: (T1, N0, M0). Also, IA: (T1a, N0, M0); IB: (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor limited to ovaries (one or both).  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1b: Tumor limited to one or both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.)-2003"                                                                                                                                                                                                                                                                                                     
 [8197] "Stage II includes: (T2, N0, M0).  Also, IIA: (T2a, N0, M0); IIB: (T2b, N0, M0); IIC: (T2c, N0, M0). T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  T2a: Extension and/or implants on uterus and/or tube(s).  No malignant cells in ascites or peritoneal washings.  T2b: Extension to and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washings.  N0: No regional metastasis.  (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                              
 [8198] "Stage II includes: (T2, N0, M0).  Also, IIA: (T2a, N0, M0); IIB: (T2b, N0, M0); IIC: (T2c, N0, M0).  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  T2a: Extension and/or implants on uterus and/or tube(s).  No malignant cells in ascites or peritoneal washings.  T2b: Extension to and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washings.  N0: No regional metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                              
 [8199] "Stage III includes: (T3, N0, M0).  Also, IIIA: (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c N0, M0) and (Any T, N1, M0).  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor).  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                             
 [8200] "Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes peritoneal metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8201] "Stage III includes: (T3, N0, M0).  Also, IIIA: (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c N0, M0) and (Any T, N1, M0).  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor).  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis. N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                               
 [8202] "Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes peritoneal metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8203] "Stage I includes: (T1, N0, M0). Also, IA: (T1a, N0, M0); IB: (T1b, N0, M0); IC (T1c, N0, M0). T1: Tumor limited to ovaries (one or both).  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1b: Tumor limited to one or both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.)-2003"                                                                                                                                                                                                                                                                                                      
 [8204] "Stage II includes: (T2, N0, M0).  Also, IIA: (T2a, N0, M0); IIB: (T2b, N0, M0); IIC: (T2c, N0, M0).  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  T2a: Extension and/or implants on uterus and/or tube(s).  No malignant cells in ascites or peritoneal washings.  T2b: Extension to and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washings.  N0: No regional metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                              
 [8205] "Stage III includes: (T3, N0, M0).  Also, IIIA: (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c N0, M0) and (Any T, N1, M0).  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor).  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                             
 [8206] "Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes peritoneal metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8207] "Stage I includes: (T1, N0, M0). Also, IA: (T1a, N0, M0); IB: (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor limited to ovaries (one or both).  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1b: Tumor limited to one or both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                   
 [8208] "Stage I includes: (T1, N0, M0). Also, IA: (T1a, N0, M0); IB: (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor limited to ovaries (one or both).  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1b: Tumor limited to one or both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                   
 [8209] "Stage II includes: (T2, N0, M0).  Also, IIA: (T2a, N0, M0); IIB: (T2b, N0, M0); IIC: (T2c, N0, M0).  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  T2a: Extension and/or implants on uterus and/or tube(s).  No malignant cells in ascites or peritoneal washings.  T2b: Extension to and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washings.  N0: No regional metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                              
 [8210] "Stage III includes: (T3, N0, M0).  Also, IIIA: (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c N0, M0) and (Any T, N1, M0).  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor).  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                             
 [8211] "Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes peritoneal metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8212] "Stage I includes: (T1, N0, M0). Also, IA: (T1a, N0, M0); IB: (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor limited to ovaries (one or both).  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1b: Tumor limited to one or both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                   
 [8213] "Stage II includes: (T2, N0, M0).  Also, IIA: (T2a, N0, M0); IIB: (T2b, N0, M0); IIC: (T2c, N0, M0).  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  T2a: Extension and/or implants on uterus and/or tube(s).  No malignant cells in ascites or peritoneal washings.  T2b: Extension to and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washings.  N0: No regional metastasis.  (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                             
 [8214] "Stage III includes: (T3, N0, M0).  Also, IIIA: (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c N0, M0) and (Any T, N1, M0).  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor).  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                             
 [8215] "Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes peritoneal metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8216] "Stage I includes: (T1, N0, M0). Also, IA: (T1a, N0, M0); IB: (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor limited to ovaries (one or both).  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1b: Tumor limited to one or both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                   
 [8217] "Stage II includes: (T2, N0, M0).  Also, IIA: (T2a, N0, M0); IIB: (T2b, N0, M0); IIC: (T2c, N0, M0).  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  T2a: Extension and/or implants on uterus and/or tube(s).  No malignant cells in ascites or peritoneal washings.  T2b: Extension to and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washings.  N0: No regional metastasis.  (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                             
 [8218] "Stage III includes: (T3, N0, M0).  Also, IIIA: (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c N0, M0) and (Any T, N1, M0).  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor).  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                             
 [8219] "Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes peritoneal metastasis. (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8220] "The reemergence of adenosquamous cell lung cancer after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8221] "A non-small cell lung cancer (NSCLC), histologically classified as adenosquamous carcinoma.  Carcinoma in situ with no regional lymph node metastasis and no distant metastasis (Tis, N0, M0). (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8222] "A non-small cell lung cancer (NSCLC), histologically classified as adenosquamous carcinoma.  No regional lymph node or distant metastases.  Tumor size and aggressiveness vary.  Subclassified as Stage IA (T1, N0, M0) or Stage IB (T2, N0, M0).  T1: Tumor is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, and without bronchoscopic evidence of invasion more proximal than the lobar bronchus, with neither regional lymph node nor distant metastases.  T2: Tumor has any of the following features of size or extent: more than 3 cm in greatest dimension; involves the main bronchus, 2 cm or more distal to the carina; invades the visceral pleura; associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung.  (AJCC 6th Ed.) - 2003"                                                                                                                                                   
 [8223] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8224] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8225] "A non-small cell lung cancer (NSCLC), histologically classified as adenosquamous carcinoma.  Distant metastasis is present.  Tumor can be of any size and aggressiveness, with any degree of regional lymph node metastasis (Any T, Any N, M1).  (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8226] "The reemergence of large cell lung cancer after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8227] "A non-small cell lung cancer (NSCLC), histologically classified as large cell carcinoma.  No regional lymph node or distant metastases.  Tumor size and aggressiveness vary.  Subclassified as Stage IA (T1,N0,M0) or Stage IB (T2,N0,M0).  T1: tumor is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, and without bronchoscopic evidence of invasion more proximal than the lobar bronchus, with neither regional lymph node nor distant metastases.  T2: tumor has any of the following features of size or extent: more than 3 cm in greatest dimension; involves the main bronchus, 2 cm or more distal to the carina; invades the visceral pleura; associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung."                                                                                                                                                                                 
 [8228] "A non-small cell lung cancer (NSCLC), histologically classified as large cell cell carcinoma.  Distant metastasis is present.  Tumor can be of any size and aggressiveness, with any degree of regional lymph node metastasis (Any T, Any N, M1)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8229] "The reemergence of lung adenocarcinoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8230] "A non-small cell lung cancer (NSCLC), histologically classified as adenocarcinoma.  Carcinoma in situ with no regional lymph node metastasis and no distant metastasis (Tis, N0, M0) (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8231] "A non-small cell lung cancer (NSCLC), histologically classified as adenocarcinoma.  No regional lymph node or distant metastases.  Tumor size and aggressiveness vary.  Subclassified as Stage IA (T1, N0, M0) or Stage IB (T2, N0, M0).  T1: tumor is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, without bronchoscopic evidence of invasion more proximal than the lobar bronchus, with neither regional lymph node nor distant metastases.  T2: tumor has any of the following features of size or extent: more than 3 cm in greatest dimension; involves the main bronchus, 2 cm or more distal to the carina; invades the visceral pleura; associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung.  (AJCC 6th Ed.) - 2003"                                                                                                                                                                
 [8232] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8233] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8234] "A non-small cell lung cancer (NSCLC), histologically classified as adenocarcinoma.  Distant metastasis is present.  Tumor can be of any size and aggressiveness, with any degree of regional lymph node metastasis (Any T, Any N, M1).  (AJCC 6th Ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8235] "Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8236] "Stage I includes: IA (T1, N0, M0); IB (T2, N0, M0).  T1: Tumor 3cm or less in greatest dimension, surrounded by lung or visceral pleura, without bronchoscopic evidence of invasion more proximal than the lobar bronchus, (i.e. not in the main bronchus).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8237] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8238] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8239] "Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis is present.  (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8240] "Stage 1 includes T1, N0, M0. T1: Tumor confined to the nasopharynx."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8241] "Stage 2 includes T2a,T2b,N0,M0/T1,T2,T2a,T2b,N1,M0.  T2: Tumor extends to soft tissues of oropharynx and/or nasal fossa.  T2a: without parapharyngeal extension.  T2b: with parapharyngeal extension.  N1: Unilateral metastasis in lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8242] "Stage 3 includes T1,T2a,T2b,N2,M0/T3,N0,N1,N2,M0. T3: Tumor invades bony structures and/or paranasal sinuses.  N2: Bilateral metastasis in lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8243] "Stage 4 includes T4,N0,N1,N2,M0/anyT,N3,M0/anyT,anyN,M1. T4: Tumor with intracranial extension and/or involvement of cranial nerves, infratemporal fossa, hypopharynx, or orbit.  N3: Metastasis in a lymph node(s).  M1: Distant metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8244] "Stage I includes: IA: (TI, N0, M0) and IB: (T2, N0, M0).  TI: Tumor 3 cm or less in greatest dimension surrounded by lung or visceral pleura, without bronchoscopic evidence of invasion more proximal than the lobar bronchus.  T2: Tumor with any of the following featues of size or extent: More than 3cm in greatest dimension.  Involves main brunchus, 2cm or more distal to the carina.  Invades the visceral pleura.  N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8245] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8246] "Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis present. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8247] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8248] "A non-disseminated skeletal or extraskeletal chondrosarcoma. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8249] "Chondrosarcoma that spreads to a secondary site"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8250] "The reemergence of chondrosarcoma that was in remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8251] "Stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0); (T2a, N0, M0).  T1a: Melanoma is less than or equal to 1.0mm in thickness with or without ulceration.  T1b: Melanoma is less than or equal to 1.0mm in thickness and level IV or V with ulceration.  T2a: Melanoma 1.01-2.0 - mm in thickness, no ulceration.  N0: No regional lymph node metastasis.  M0: No distant metastasis. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8252] "Stage II includes: IIA (T2b, N0, M0); (T3a, N0, M0); IIB (T3b, N0, M0); (T4a, N0, M0); IIC (T4b, N0, M0).  T2b: Melanoma 1.01 - 2.0mm in thickness, with ulceration. T3a: Melanoma 2.01 - 4.0mm in thickness, no ulceration.  T3b: Melanoma 2.01 - 4.0mm in thickness, with ulceration.  T4a: Melanoma is greater than 4.0 mm in thickness, no ulceration.  T4b: Melanoma is greater than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastasis.  M0: No distant metastasis. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8253] "Stage III includes: (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0).  N1: Metastasis in one lymph node.  N2: Metastasis in two to three regional lymph nodes or intralymphatic regional metastasis without nodal metastases.  N3: Metastasis in four or more regional nodes, or matted metastatic nodes, or in-transit metastasis or satellite(s) with metastasis in regional node(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8254] "Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8255] "The reemergence of lentigo maligna after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8256] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8257] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8258] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8259] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8260] "Stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0); (T2a, N0, M0). T1a: Melanoma is less than or equal to 1.0mm in thickness with or without ulceration. T1b: Melanoma is less than or equal to 1.0mm in thickness and level IV or V with ulceration. T2a: Melanoma 1.01-2.0 - mm in thickness, no ulceration. N0: No regional lymph node metastasis. M0: No distant metastasis. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8261] "Stage II includes: IIA (T2b, N0, M0); (T3a, N0, M0); IIB (T3b, N0, M0); (T4a, N0, M0); IIC (T4b, N0, M0).  T2b: Melanoma 1.01 - 2.0mm in thickness, with ulceration.  T3a: Melanoma 2.01 - 4.0mm in thickness, no ulceration.  T3b: Melanoma 2.01 - 4.0mm in thickness, with ulceration.  T4a: Melanoma is greater than 4.0 mm in thickness, no ulceration.  T4b: Melanoma is greater than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastasis.  M0: No distant metastasis. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8262] "Stage III includes: (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0).  N1: Metastasis in one lymph node.  N2: Metastasis in two to three regional lymph nodes or intralymphatic regional metastasis without nodal metastases. N3: Metastasis in four or more regional nodes, or matted metastatic nodes, or in-transit metastasis or satellite(s) with metastasis in regional node(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8263] "Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8264] "Reemergence of malignant fibrous histiocytoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8265] "Alveolar soft part sarcoma spreading to another site"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8266] "Alveolar soft part sarcoma not spreading from its primary site"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8267] "The reemergence of alveolar soft part sarcoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8268] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8269] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8270] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8272] "Reemergence of extra-osseous ewing's sarcoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8273] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8274] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8275] "Reemergence of extraskeletal chondrosarcoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8276] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8277] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8278] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8279] "Reemergence of extraskeletal osteosarcoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8280] "A fibrosarcoma which has spread from its original location."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8281] "A leiomyosarcoma which has spread from its initial site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8282] "A leiomyosarcoma which has not spread from its initial site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8283] "The reemergence of leiomyosarcoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8284] "Liposarcoma that has metastasized to a secondary site"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8285] "Liposarcoma that does not metastasize to secondary sites"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8286] "The reemergence of liposarcoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8287] "The presence of malignant Schwann cell growth (benign variant is known as neurofibroma) at a site removed from the primary site of tumor growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8288] "A malignant tumor of neural sheath origin-lesions reappearing after an intermission or remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8289] "The reemergence of rhabdomyosarcoma after a period of remission. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8290] "A synovial sarcoma that has metastasized to other anatomic sites. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8291] "Synovial sarcoma affecting an anatomic site as a primary tumor.--2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8292] "The reemergence of synovial sarcoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8293] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8294] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8295] "Stage III adult Hodgkin's disease means the involvement of lymph node regions on both sides of the diaphragm (III), which may also be accompanied by localized involvement of an associated extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or by involvement of both (IIIE + S). Stage III disease may be subdivided by anatomic distribution of abdominal involvement or by extent of splenic involvement. Stage III(1) indicates involvement that is limited to the upper abdomen above the renal vein. Stage III(2) indicates involvement of pelvic and/or para-aortic nodes. Five or more visible splenic nodules on a cut section constitutes extensive splenic involvement. Zero to four nodules is classified as minimal splenic disease. (from PDQ)"                                                                                                                                                                                                             
 [8296] "Stage IV adult Hodgkin's disease means there is disseminated (multifocal) involvement of one or more extralymphatic organs, with or without associated lymph node involvement, or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8297] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8298] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8299] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8300] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8301] "Hodgkin's disease resistant to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8302] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8303] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8304] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8305] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8306] "The reemergence of B-cell lymphoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8307] "B-cell non-Hodgkin's lymphoma that is resistant to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8308] "Stage II NHL means involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8309] "Stage III NHL means involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8310] "Stage IV NHL means disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8311] "B-cell small lymphocytic lymphoma that is resistant to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8312] "Burkitt's lymphoma that is resistant to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8313] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8314] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8315] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8316] "This non-Hodgkin's lymphoma is characterized by a diffuse proliferation of predominantly large neoplastic B lymphocytes.  It is the most frequently seen type of non-Hodgkin's lymphoma, representing 30%-40% of the cases.  Morphologic variants include centroblastic lymphoma, immunoblastic lymphoma, T-cell/histiocyte rich lymphoma, anaplastic lymphoma, plasmablastic lymphoma, and diffuse large B-cell lymphoma with expression of full-length ALK. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8317] "The reemergence of diffuse large B-cell lymphoma after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8318] "Diffuse large B-cell lymphoma that is resistant to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8319] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8320] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8321] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8322] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8323] "Follicle centre lymphoma, follicular grade I, II, III that is resistant to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8324] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8325] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8326] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8327] "Mantle cell lymphoma resistant to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8328] "A primary nodal B-cell non-Hodgkin's lymphoma which morphologically resembles lymph nodes involved by marginal zone lymphomas of extranodal or splenic types, but without evidence of extranodal or splenic disease.  This is a rare entity, and most patients present with localized or generalized lymphadenopathy.  The clinical course is indolent.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8329] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8330] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8331] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8332] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8333] "An uncommon type of lymphoma and constitutes approximately 10% of cases of lymphoblastic lymphoma.  Approximately 75% of cases reported in a literature review were less than 18 years of age.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8334] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8335] "Precursor B-lymphoblastic lymphoma resistant to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8336] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8337] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8338] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8339] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8340] "Primary mediastinal large B-cell lymphoma resistant to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8341] "Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8342] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8343] "Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8344] "Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8345] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8346] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8347] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8348] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8349] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8350] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8351] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8352] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8353] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8354] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8355] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8356] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8357] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8358] "An epithelial malignancy of trophoblastic cells, formed by the abnormal proliferation of cuboidal and syncytial cells of the placental epithelium, without the production of chorionic villi. Almost all cases arise in the uterus, developing from hydatidiform mole (50%), following abortion (25%), or during normal pregnancy (22%). The remainder occur in ectopic pregnancy and genital (ovarian and testicular) and extragenital teratomas. (Dorland, 27th ed). This concept specifically refers to this tumor arising in the placenta."                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8359] "Stage 0 includes Ta,Tis,N0,M0.  Ta: Noninvasive papillary carcinoma.  Tis: Carcinoma in situ: \"flat tumor\".  N0: No regional lymph node metastasis.  M0: No distant metastasis (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8360] "TNM stage: T1, N0, M0 (T1 is tumor that invades subepithelial connective tissue, N 0 means no lymph node metastases, M 0 means no distant metastases) from PDQ"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8361] "TNM stage: T2 a or b, N0, M0 (T2a is tumor that invades superficial muscle, T2b invades deep muscle, N 0 means no lymph node metastases, M 0 means no distant metastases) from PDQ"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8362] "TNM stage: T3 a or b, T4a,, N0, M0 (T3 is tumor that invades paravesical tissue ,T3a is microscopic invasion, T3b is macroscopic invasion, T4a is invasion of the prostate uterus or vagina, N 0 means no lymph node metastases, M 0 means no distant metastases) from PDQ"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8363] "Stage 4 includes T4b,N0,M0/anyT,N1-3,M0/anyT,anyN,M1.  T4b: Tumor invades the pelvic wall, abdominal wall.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension.  M1: Distant metastasis (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8364] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8365] "Stage 3 includes anypT,anyN,M1,SX.  N1:Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension.  M1: Distant metastasis (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8366] "Stage I includes T1, NO, MO. T1: Tumor invades subepithelial connective tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8367] "The reemergence of bladder squamous cell carcinoma after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8368] "Staging is by TNM classification. Stage O would include Ta NO MO.  Ta: Noninvasive papillary carcinoma.  N0: No regional lymph node metastasis.  M0: No distant metastasis"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8369] "TNM staging: T1 N0 M0- T1 means tumor invades subepithelial connective tissue, N0 means no regional lymph node mets, M0 means no distant mets."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8370] "TNM staging: T3a/b or T4 and N0 M0-T3a means tumor invades perivesicular tissue microscopically, ,T3b means tumor invades macroscopically, T4 indicates invasion of prostate, uterus or vagina, N0 means no regional lymph node mets, M0 means no distant mets."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8371] "Stage IV would include T4b NO MO/any T N1 MO/ any T N2 MO/ any T N3 MO/ any T any N M1. T4b: Tumor invades the pelvic wall, abdominal wall.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. N3: Metastasis in a lymph node more than 5 cm in greatest dimension.  M1: Distant metastasis"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8372] "Stage 1 includes pT1-T4,N0,M0,SX.  pT1: Tumor limited to testis and epididymis without lymphatic/vascular invasion.  pT2: Tumor limited to testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis.  pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion.  pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  SX: Marker studies not available or not performed."                                                                                                                                                                                                                                                                                                                                                                                                              
 [8373] "Stage I includes: pT1-4, N0, M0,SX.  pT1: Tumor limited to testis and epididymis without lymphatic/vascular invasion.  pT2: Tumor limited to testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis.  pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion.  pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  SX: Marker studies not available or not performed.  - 2003"                                                                                                                                                                                                                                                                                                                                                                                                    
 [8374] "Stage II includes: Any pT, N1-3, M0, SX. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. N3: Metastasis in a lymph node more than 5 cm in greatest dimension. M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8375] "Stage III includes: Any pT, Any N, M1, SX.  M1:distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8376] "Stage 2 includes anypT,N1-3,M0,SX.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8377] "Stage 1 includes pT1-T4,N0,M0,SX.  pT1: Tumor limited to testis and epididymis without lymphatic/vascular invasion.  pT2: Tumor limited to testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis.  pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion.  pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  SX: Marker studies not available or not performed."                                                                                                                                                                                                                                                                                                                                                                                                              
 [8378] "Stage 3 includes anypT,anyN,M1,SX.  M1:Distant metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8379] "Stage 1 includes pT1-T4,N0,M0,SX.  pT1: Tumor limited to testis and epididymis without lymphatic/vascular invasion.  pT2: Tumor limited to testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis.  pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion.  pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  SX: Marker studies not available or not performed."                                                                                                                                                                                                                                                                                                                                                                                                              
 [8380] "Stage 2 includes anypT ,N1-3,M0,SX.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8381] "Stage 3 includes anypT,anyN,M1,SX.  M1: Distant metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8382] "Stage 1 includes pT1-4, N0,M0,SX.  pT1: Tumor limited to testis and epididymis without lymphatic/vascular invasion.  pT2: Tumor limited to testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis.  pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion.  pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  SX: Marker studies not available or not performed."                                                                                                                                                                                                                                                                                                                                                                                                              
 [8383] "Stage 2 includes anypT,N1-3,M0,SX. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8384] "Stage 3 includes anypT, anyN, M1,SX.  M1:distant metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8385] "Stage 1 includes pT1-4, N0,M0,SX.  pT1: Tumor limited to testis and epididymis without lymphatic/vascular invasion.  pT2: Tumor limited to testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis.  pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion.  pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  SX: Marker studies not available or not performed."                                                                                                                                                                                                                                                                                                                                                                                                              
 [8386] "Stage 2 includes anyT, N1-3, M0,SX.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8387] "Stage 3 includes anypT,anyN,M1,SX. M1:distant metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8388] "An acute myeloid leukemia characterized by a predominant immature erythroid population.  There are two subtypes recognized: erythroleukemia and pure erythroid leukemia.  Severe anemia is a common symptom.  This leukemia usually follows an aggressive clinical course.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8389] "Self-limiting form of Erythema Multiforme."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8390] "A melanoma that has spread from its primary site to another anatomic site.  Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8391] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8392] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8393] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8394] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8395] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8396] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8397] "Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial or invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastais. (AJCC 6th ed.)-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8398] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8399] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8400] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8401] "A neoplasm of lymphoblasts committed to the B-cell lineage, typically composed of small to medium-sized blast cells.  When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called precursor B lymphoblastic leukemia (B-cell acute lymphoblastic leukemia).  When it involves nodal or extranodal sites, it is called B lymphoblastic lymphoma. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8402] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8403] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8404] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8405] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8406] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8407] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8408] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8409] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8410] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8411] "Prostate tumor cells spreading and reestablishing themselves in another organ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8412] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8413] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8414] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8415] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8416] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8417] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8418] "A malignant neoplasm, with unspecified histology, of the lung that has returned after treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8419] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8420] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8421] "T4,N2,MO (from PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8422] "A skin disease marked by scaly or thickened patches on the skin, and often caused by prolonged exposure to arsenic.  The patches often occur on sunexposed areas of the skin and in older white men.  These patches may become malignant (cancerous).  Also called Bowen's disease or precancerous dermatitis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8423] "Stage IV includes: (T4, Any N, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades other adjacent structures.  N3: Metastasis in deep inguinal or pelvic lymph node(s) unilateral or bilateral.  M1: Distant metastasis.  (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8424] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8425] "The most common gastric polyp in the Western hemisphere.  The lesion consists of a localized hyperplasia of the deep epithelial compartment of the oxyntic mucosa, with variable degrees of cystic dilatation.  Malignant transformation is the exception.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8426] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8427] "Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes metastasis within the peritoneal cavity. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8428] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8429] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8430] "Ataxia associated with chaotic multidirectional conjugate eye movements secondary to metastatic tumors to cerebellum.  The most common malignant tumor associated with this paraneoplastic syndrome is lung carcinoma. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8431] "A rare neuroaxonal dystrophy, histologically characterized by axonal spheroids, iron deposition, lewy body (LB)-like intraneuronal inclusions and neurofibrillary tangles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8432] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8433] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8434] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8435] "(EM-bree-on-al RAB-do-MY-oh-sar-KO-ma) A soft-tissue tumor that affects children. It begins in muscle cells, and usually occurs in the head, neck, arms, legs, or genitourinary tract."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8436] "An endometrial stromal sarcoma.  This is a high grade sarcoma --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8437] "A uterine stromal sarcoma originating from the endometrium.  It is further subdivided into low grade endometrial stromal sarcoma and undifferentiated uterine sarcoma. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8438] "An aggressive malignant tumor of the female reproductive system, affecting predominantly elderly menopausal women.  The endometrium and ovary are the most common sites of tumor origin.  Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8439] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8440] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8441] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8442] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8443] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8444] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8445] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8446] "A benign or malignant tumor involving the oral cavity and/or the lips. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8447] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8448] "Malignant neoplasm originating from mast cells. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8449] "A carcinoma of the ureter.  The majority of ureter carcinomas are transitional cell and less frequently squamous cell carcinomas or adenocarcinomas.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8450] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8451] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8452] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8453] "A malignant neoplasm composed of undifferentiated cells. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8454] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8455] "A malignant neoplasm made up of squamous epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8456] "A benign neoplasm that can arise from any of the adrenal cortical layers.  It can be associated with the overproduction of glucocorticoids (Cushing's syndrome), androgenic or estrogenic steroids (adrenogenital syndrome), or mineralocorticoids (Conn's syndrome). (Diagnostic Surgical Pathology, 3rd ed.) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8457] "A non-metastasizing neoplasm of the adrenal cortex. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8458] "A malignant tumor involving the pancreas.  Representative examples include carcinoma and lymphoma. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8459] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8460] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8461] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8462] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8463] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8464] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8465] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8466] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8467] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8468] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8469] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8470] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8471] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8472] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8473] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8474] "An astrocytoma appearing before the age of twenty one without designation of benign or malignant nor designated location."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8475] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8476] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8477] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8478] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8479] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8480] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8481] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8482] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8483] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8484] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8485] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8486] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8487] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8488] "Cancer has spread to nearby tissues and to lymph nodes further away from the tumor or has spread to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8489] "Cancer that has spread beyond the top layer of anal tissue and is smaller than 2 centimeters (smaller than 1 inch)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8490] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8491] "Cervical carcinoma may arise from either the exocervical squamous epithelium or the endocervical glandular epithelium.  The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8492] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8493] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8494] "An abnormal growth of the cells that comprise the tissues of the brainstem. While the tumor may be histologically benign, it can produce great morbidity due to its location.  It presents most commonly in the first two decades of life."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8495] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8496] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8497] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8498] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8499] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8500] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8501] "Cancer that has spread outside the lung to other tissues in the chest or to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8502] "The reemergence of small cell carcinoma of the lung after a period of remission. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8503] "Cancer that is found in the vulva, the space between the opening of the rectum and the vagina (perineum), or both.  The tumor is larger than 2 centimeters (larger than 1 inch)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8504] "Cancer is found in the vulva, perineum, or both. The cancer has also spread to nearby tissues such as the lower part of the urethra (the tube through which urine passes), the vagina, and the anus (the opening of the rectum); to nearby lymph nodes; or both."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8505] "Cancer has spread beyond the urethra, vagina, and anus into the lining of the bladder (the sac that holds urine) and the bowel (intestine); or it may have spread to the lymph nodes in the pelvis or to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8506] "Cancer that recurs after a period of remission following treatment for vulval cancer.  It may come back in the vulva or another place."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8507] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8508] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8509] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8510] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8511] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8512] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8513] "Tumors of the penis make up approximately 1% to 1.5% of cancers in the male population in the United States and Europe.  Risk factors include: phimosis (narrowing of the foreskin or prepuce) and Human Papilloma Viruses.  The majority of penile cancers are squamous cell carcinomas.  The most frequent clinical presentation is an irregular mass in the glans of the penis. Treatment includes: surgical management, radiation therapy (external beam and brachytherapy). - 2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8515] "A malignant tumor predominantly affecting young men and often associated with cryptorchidism.  Seminoma is the most frequently seen malignant testicular germ cell tumor, followed by embryonal carcinoma and yolk sac tumor. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8516] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8517] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8518] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8519] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8522] "Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8523] "Reemerging endometrial cancer after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8524] "Cancer has spread to the lymph nodes in the abdomen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8525] "Cancer has spread beyond the lymph nodes in the abdomen. There may be cancer in parts of the body far away from the testicles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8526] "Cancer cells have spread to lymph nodes (near or far from the prostate) or to organs and tissues far away from the prostate such as the bone, liver, or lungs. Similar to stage D in the Whitmore-Jewett staging system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8527] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8529] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8530] "A morphologically malignant thymoma that is entirely confined within the capsule.  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8531] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8534] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8535] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8536] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8537] "(KAP-o-seez sar-KO-ma) A type of cancer characterized by the abnormal growth of blood vessels that develop into skin lesions or occur internally."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8538] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8539] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8540] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8541] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8542] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8543] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8544] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8545] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8546] "Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8547] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8548] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8549] "Stage 0 includes: (Tis, N0 ,M0).  Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8550] "Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8551] "Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8552] "Stage 3a includes T1 or T2,N2,MO/T3,N1 or N2,MO. N2: Metastasis to ipsilateral mediastinal and/or subcarinal lymph node(s)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8553] "Stage 3b includes anyT,N3,MO/T4,anyN,MO. T4: A tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, esophagus, vertebral body, carina; or separate tumor nodules in the same lobe; or tumor with a malignant pleural effusion. N3: Metastasis to contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph node(s)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8554] "Stage 0 includes Tis,NO,MO.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8555] "Malignant neoplasms of the oral cavity and pharynx"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8556] "Abnormal malignant growth of cells in the urethra (lower urinary tract)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8557] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8558] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8559] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8560] "Refers to advanced chronic myelogenous leukemia. In this phase, the number of immature, abnormal white blood cells in the bone marrow and blood is extremely high. Also called blast crisis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8561] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8562] "This is a vascular sarcoma that commonly occurs in the lower extremities.  It occurs predominantly in elderly male patients of southern European ancestry.  This disease is usually slow growing, although it can spread to the lungs and the gastrointestinal tract.  If found necessary cutaneous lesions can be treated with radiation. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8563] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8564] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8565] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8566] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8568] "A cancer of the bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8569] "(MED-yoo-LAIR-ee) A rare type of breast cancer that often can be treated successfully. It is marked by lymphocytes (a type of white blood cell) in and around the tumor that can be seen when viewed under a microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8570] "A carcinoma occurring almost exclusively in adults that probably arises from the pancreatic duct epithelium.  Most pancreatic carcinomas are ductal adenocarcinomas of which about two-thirds involve the head, with the remainder in the body and tail of the pancreas.  The patients are usually over 50 years of age.  Pain, jaundice, and loss of weight are the most common manifestations.  Ductal adenocarcinomas usually grow rapidly and are discovered after they have already spread beyond the pancreas.  Grossly, ductal adenocarcinomas are firm and poorly defined masses.  Microscopically, most ductal adenocarcinomas are characterized by well-developed glandular structures embedded in a desmoplastic stroma.  Ductal adenocarcinomas are fatal in the vast majority of cases (WHO 2000). --2002"                                                                                                                                                                             
 [8571] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8572] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8573] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8574] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8575] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8576] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8577] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8578] "A chronic myelogenous leukemia characterised by the t(9;22)(q34;q11) chromosomal translocation, resulting in the presence of the Philadelphia chromosome. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8579] "A chronic myelogenous leukemia which does not express the Philadelphia chromosome abnormality. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8580] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8581] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8582] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8583] "A non-small cell lung cancer (NSCLC), histologically composed of malignant glandular and malignant squamous epithelial cells.  It composes about 3.5% of surgically resected lung carcinomas.  The outcome of adenosquamous lung carcinomas is significantly poorer than that of adenocarcinomas and squamous cell carcinomas (adapted from Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999). --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8584] "A malignant breast neoplasm characterized by the formation of irregular, finger-like projections of fibrous stroma covered with neoplastic epithelial cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8585] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8586] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8587] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8588] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8589] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8590] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8591] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8592] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8593] "(AHS-tee-o-sar-KO-ma) A cancer of the bone that usually affects the large bones of the arm or leg. It occurs most commonly in young people and affects more males than females. Also called osteogenic sarcoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8594] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8595] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8596] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8597] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8598] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8599] "(LMM) makes up approximately 10% of all melanomas.  This type usually occurs in elderly people with the median age of 70.  LMM lesions are typically flat with irregular borders and shades of color which run form tan to dark brown. -2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8600] "A type of melanoma that typically occurs in light-skinned individuals ranging in age from young adults to the elderly.  Risk factors include extensive sun exposure during childhood, a family history of melanoma, and the presence of dysplastic nevi. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8601] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8602] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8603] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8604] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8605] "Intestinal adenocarcinomas of the stomach closely resemble colonic adenocarcinomas.  Grossly, they tend to be nodular, polypoid or ulcerated.  Microscopically, they have a glandular pattern. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8607] "Diffuse adenocarcinomas of the stomach have a plaque-like surface component.  Microscopically, there is a diffuse infiltrate, composed of individual cells or groups of cells in a fibrous or mucoid stroma.  Many cells contain mucin droplets, producing a signet-ring configuration. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8608] "Acute myeloid leukemia occuring in childhood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8609] "A squamous cell carcinoma (SCC) arising in the anal canal or the anal margin (perianal skin).  The distinction between anal canal and anal margin SCC may be difficult, as tumors often involve both areas at the time of diagnosis.  The prognosis is generally better for anal margin SCC than for anal canal SCC.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8610] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8611] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8612] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8613] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8614] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8615] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8616] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8617] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8618] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8619] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8620] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8621] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8622] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8623] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8624] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8625] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8626] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8627] "A rare malignancy of mixed histological type involving endometrial adenocarcinoma and sarcomatous cells. Uterine carcinosarcoma is associated with prior radiation therapy as a risk factor. While hysterosalpingooophorectomy is usually performed in an attempt to contain the disease, further clinical trials will need to be done to optimize the chemotherapy and/or radiation therapy regimen for these patients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8628] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8629] "A tumor of the tissue that surrounds muscles, usually in the abdomen. A desmoid tumor rarely metastasizes (spreads to other parts of the body).  Also called aggressive fibromatosis, especially when the tumor is outside the abdomen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8630] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8631] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8632] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8633] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8634] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8635] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8636] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8637] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8638] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8639] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8640] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8641] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8642] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8643] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8644] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8645] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8646] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8647] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8648] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8649] "Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8650] "Intense increases in pain that occur with rapid onset even when pain-control medication is being used.  Breakthrough pain can occur spontaneously or in relation to a specific activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8651] "Cancer that involves the cervix but has not spread to nearby tissues. In stage IA cancer of the cervix, a very small amount of cancer that is only visible under a microscope is found deeper in the tissues of the cervix. In stage IB cancer, a larger amount of cancer is found in the tissues of the cervix."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8652] "Cancer has spread throughout the pelvic area, and cancer cells may have spread to the lower part of the vagina. The cells also may have spread to block the tubes that connect the kidneys to the bladder (the ureters)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8653] "Cancer has spread to other parts of the body. In stage IVA cancer of the cervix, cancer has spread to the bladder or rectum (organs close to the cervix); in stage IVB cancer of the cervix, cancer has spread to distant organs such as the lungs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8654] "Stage I includes: I (T1, N0, M0); IA: (T1a, N0, M0); IB (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor confined to corpus uteri. T1a: Tumor limited to the endometrium.  T1b: Tumor invades less than one-half of the myometrium.  T1c: Tumor invades one-half or more of the myometrium.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8655] "Cancer that has spread to the cervix."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8656] "Cancer cells have spread outside the uterus to the vagina and/or lymph nodes in the pelvis but have not spread outside the pelvis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8657] "Cancer that is found in the lining of the esophagus but has not spread to nearby tissues, lymph nodes, or other organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8658] "Cancer that may be found in all layers of esophageal tissue and may have spread to regional lymph nodes, but has not spread to other tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8659] "Cancer has spread to tissues or lymph nodes near the esophagus but has not spread to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8660] "Cancer has spread to lymph nodes and other parts of the body far from the esophagus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8661] "Cancer that is smaller than 5 centimeters (smaller than 2 inches) and has not spread into tissues around the adrenal gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8662] "Cancer that is larger than 5 centimeters (about 2 inches) and has not spread into tissues around the adrenal gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8663] "The cancer has spread into tissues around the adrenal gland or has spread to the lymph nodes around the adrenal gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8664] "The cancer has spread to tissues or organs in the area and to lymph nodes around the adrenal cortex, or the cancer has spread to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8665] "Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a: Tumor invades the larynx, deep/extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible. T4b: Tumor invades lateral pterygoid muscle, pterygoid plates lateral nasopharynx, or skull base or encases carotid artery. M1: Distant Metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8666] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8667] "Kidney cancer that has spread to the major veins of the kidney and may have spread to a single lymph node."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8668] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8669] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8670] "Inflammation of the esophagus (the tube that carries food from the mouth to the stomach)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8671] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8672] "Cancer that does not begin in the blood or bone marrow."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8673] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8674] "Disease that cannot be cured and will cause death."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8675] "Disease that affects the whole body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8676] "A condition in which bone marrow activity is decreased, resulting in fewer red blood cells, white blood cells, and platelets.  Myelosuppression is a side effect of some cancer treatments."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8677] "A rare type of cancer that develops on or just beneath the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8678] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8679] "A myelodysplastic/myeloproliferative disease of childhood that is characterized by proliferation principally of the granulocytic and monocytic lineages.  Myelomonocytic proliferation is seen in the bone marrow and the blood.  The leukemic cells may infiltrate any tissue, however liver, spleen, lymph nodes, skin, and respiratory tract are the most common sites of involvement.  The prognosis is usually poor.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8680] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8681] "A variant of mastocytosis characterized by multifocal, dense infiltrates of mast cells (15 or more mast cells in aggregates) detected in the bone marrow and/or other extracutaneous sites. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8682] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8683] "The reemergence of gastric cancer after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8684] "The reemergence of rectal cancer after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8685] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8686] "The reemergence of nasopharyngeal cancer after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8687] "The reemergence of hypopharyngeal cancer after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8688] "Malignant tumor of the colon or rectum. Loss of imprinting (LOI) of the insulin-like growth factor II (IGF2) gene is suggested to be associated with a predisposition to sporadic colorectal cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8689] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8690] "A quickly growing cancer that arises in the cells of the lymphatic system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8691] "A carcinoma that infiltrates the breast parenchyma.  The vast majority are adenocarcinomas arising from the terminal ductal lobular unit (TDLU).  Often, the invasive adenocarcinoma co-exists with ductal or lobular carcinoma in situ.  It is the most common carcinoma affecting women. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8692] "Inflamatory breast carcinoma is classified as AJCC Stage IIIB (T4d) unless other criteria indicate more advanced staging."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8693] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8694] "An imprecise term applied to (1) any small nodular delimited aggregation of mononuclear inflammatory cells, or (2) such a collection of modified macrophages resembling epithelial cells, usually surrounded by a rim of lymphocytes, often with multinucleated giant cells. Some granulomas contain eosinophils and plasma cells, and fibrosis is commonly seen around the lesion. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents, including silicon. (Dorland, 27th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8695] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8696] "The reemergence of anaplastic large cell lymphoma T-and null cell types after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8697] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8698] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8699] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8700] "A rare malignant sarcoma, believed to have its origin in smooth muscle derived pericytes, that has recurred after treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8701] "The reemergence of ureter cancer after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8702] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8703] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8704] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8705] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8706] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8707] "The reemergence of hepatic neoplasm malignant after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8708] "Mature T and NK neoplasms predominantly affecting the skin and the peripheral blood.  Peripheral blood involvement by abnormal T-cells (cerebriform cells) is a late manifestation of mycosis fungoides, whereas it is the presenting finding in Sezary syndrome. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8709] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8710] "A low- or high-grade bladder papillary carcinoma which is confined to the bladder transitional cell epithelium and does not invade into the lamina propria. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8711] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8712] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8713] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8714] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8715] "Malignant neoplasm of the salivary glands"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8716] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8717] "A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed) This concept specifically states that there is no evidence of metastases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8718] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8719] "A myeloid or more commonly lymphoid leukemia (acute or chronic) affecting the testis.  Microscopically, there is interstitial infiltration of the testis by leukemic cells.  Acute lymphoblastic leukemia with testicular involvement is not uncommon in boys.  Sometimes (up to 10% of the cases), testicular involvement may be the initial manifestation of relapsed acute lymphoblastic leukemia.  --03"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8720] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8721] "Hodgkins disease secondary to AIDS"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8722] "A large B-cell non-Hodgkin's lymphoma arising in the mediastinum.  Morphologically it is characterized by a massive diffuse lymphocytic proliferation associated with compartmentalizing fibrosis.  Response to intensive chemotherapy, with or without radiotherapy, is usually good. (WHO, 2001) --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8723] "A neoplastic proliferation of spindled to ovoid cells which show morphologic and phenotypic features of follicular dendritic cells.  It behaves like a low grade tissue sarcoma. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8724] "A neoplastic proliferation of spindle to ovoid cells which show phenotypic features similar to those of interdigitating dendritic cells.  The clinical course is variable ranging from benign localized disease to widespread lethal disease. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8725] "A diffuse form of classical Hodgkin's lymphoma which is rich in Hodgkin's and Reed-Sternberg cells and/or depleted in non-neoplastic lymphocytes.  Historically, the clinical course of this type of Hodgkin's lymphoma was aggressive.  With current therapy, the course is comparable to patients with other subtypes of classical Hodgkin's lymphoma. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8726] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8727] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8728] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8729] "An acute myeloid leukemia (AML) with inv(16)(p13q22) or t(16;16)(p13;q22);(CBF-beat/MYH11).  This AML shows monocytic and granulocytic differentiation and the presence of a characteristically abnormal eosinophil component in the bone marrow.  This type of AML has a favorable prognosis.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8730] "An acute myeloid leukemia (AML) showing maturation in the neutrophil lineage.  The bone marrow and the peripheral blood show large myeloblasts with abundant basophilic cytoplasm, often containing azurophilic granules.  This type of AML is associated with good response to chemotherapy and high complete remission rate.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8731] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8732] "A clonal (malignant) proliferation of myeloid (erythroid, granulocytic, or megakaryocytic) cells originating from a primitive stem cell. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8733] "A carcinoma that arises from the anus.  Anal carcinomas include the anal canal and anal margin (perianal skin) carcinomas.  The anal margin carcinoma is staged separately as a skin carcinoma.  Anal cancer stage terms are usually used as synonyms for anal canal cancer stage terms.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8734] "Cancer of body tissues other than blood, bone marrow, or the lymphatic system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 [8735] "Abnormal growth of cells that comprise the tissues of the central nervous system (brain and spinal cord), without designation of benign or malignant nature."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8736] "These are rare tumors that affect the hematopoietic and lymphoid tissues.  The cells of origin are the histiocytes and accessory cells. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8737] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8738] "Adenocarcinomas that straddle the gastroesophageal junction.  This definition includes adenocarcinomas formerly called carcinomas of the gastric cardia.  These carcinomas are more frequently seen in middle-aged and older white males and are associated with gastro-esophageal reflux.  Adenocarcinomas in the gastroesophageal junction can be graded as well, moderately or poorly differentiated (adapted from WHO, 2000). --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8739] "A primary or metastatic malignant tumor involving the urinary tract.  Common tumor types include carcinomas, lymphomas, and sarcomas. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8740] "A leukemia originating from a precursor bone marrow cell which is in an earlier developmental stage compared to lymphoblasts and myeloblasts. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8741] "An acute leukemia of ambiguous lineage in which the blasts lack sufficient evidence to classify as myeloid or lymphoid.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8742] "A clonal (malignant) hematopoietic disorder affecting the bone marrow and the peripheral blood.  The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).  According to the type of blasts present, acute leukemias are classified as acute myeloid leukemia (AML) and precursor lymphoblastic or acute lymphoblastic leukemia (ALL). -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8743] "A non-Hodgkin's or Hodgkin's lymphoma affecting the brain and/or the spinal cord.  A central nervous system lymphoma can be either primary or metastatic from another anatomic site. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8744] "Cancer that arises in the lymphoid tissue found in the central nervous system (CNS). The CNS includes the brain and spinal cord."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8745] "A nodule of mast cells.  Mastocytomas can involve the skin, subcutaneous tissue, and sometimes muscle. Also called a mast cell tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8746] "A heterogeneous group of disorders characterized by the abnormal growth and accumulation of mast cells in one or more organ systems.  Recent data suggest that most variants of mastocytosis are clonal disorders. (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8747] "A cancerous tumor that can invade and destroy nearby tissue and spread to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8748] "(TISH-oo sar-KO-ma) A sarcoma that begins in the muscle, fat, fibrous tissue, blood vessels, or other supporting tissue of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8749] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8750] "A disorder characterized by proliferation of lymphocytes at various stages of differentiation. Lymphproliferative disorders can be neoplastic (clonal, as in lymphomas and leukemias) or reactive (polyclonal, as in infectious mononucleosis). --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8751] "(sem-in-O-ma) A type of cancer of the testicles. Seminomas may spread to the lung, bone, liver, or brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8752] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8753] "Primary or metastatic malignant neoplasm involving the cervix. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8754] "A malignant mesenchymal tumor of the bone.  Bone sarcomas can either arise from the bones (primary bone sarcomas) or spread to the bones from other anatomic sites. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8755] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8756] "A malignant tumor involving the oral cavity.  The majority are squamous cell carcinomas. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8757] "A carcinoma arising in the lip or oral cavity.  Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums.  Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma.  Lip carcinomas are usually basal cell or squamous cell carcinomas. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8758] "A malignant tumor involving the lip and/or oral cavity.  The majority are carcinomas. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8759] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8760] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8761] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8762] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8763] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8764] "Malignant growth of the cells that comprise the parathyroid gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8765] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8766] "The adrenal gland is composed of the adrenal cortex and the adrenal medulla.  The primary carcinomas of the adrenal gland arise from the adrenal cortex and are called adrenal cortex adenocarcinomas.  Any carcinoma can metastasize to the adrenal gland.  Such metastatic carcinomas can involve either the adrenal cortex and or the adrenal medulla. -2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8767] "A primary or metastatic carcinoma that involves the adrenal cortex. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8768] "A malignant neoplasm of adrenal cortical cells which demonstrate partial or complete histological and functional differentiation. Adrenal cortex carcinomas (ACCs) are rare, comprising between only 0.05% and 0.2% of all cancers. Functional ACCs are more common in women while nonfunctioning ACCs are more common in men. Hypercortisolism is the most common hormonal abnormality observed in this cancer; patients may also present with virilism or Cushing's syndrome. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8769] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8770] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8771] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8772] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8773] "Primary or metastatic malignant neoplasm of the stomach"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8774] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8775] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8776] "Abnormal malignant growth of the cells within the bladder. - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8777] "A breast neoplasm with metastatic potential arising from the breast parenchyma or the nipple.  The most common are breast carcinomas.  Malignant breast neoplasms occur more frequently in females than in males. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8778] "Malignant neoplasm of the nasal cavity"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8779] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8780] "A malignant growth of adrenal cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8781] "Peripheral T-cell lymphoma unspecified resistant to treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8782] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8783] "Intraocular Melanoma is derived from melanocytes of the uveal tract.  This tumor is the most common primary intraocular tumor in the United States and Western Europe.  Simular to melanoma of the skin it is rare in Africa and Asia.  Diagnostic procedures include ophthalmoscopic exam, flurescein angiograph and ultrasound.  Treatment includes: surgical excision of the eye, iridocyclectomy and tumor resection.  Recently treatment as also included radiotherapy or photo coagulation.  Classification of uveal melanomas recognizes four cell types within these tumors. Spindle A and B cells are included in this classification. - 2002"                                                                                                                                                                                                                                                                                                                                             
 [8784] "A benign or malignant (primary or metastatic) tumor involving the bone.  Common malignant tumor types involving the bones are metastatic carcinomas and sarcomas. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8785] "(PIN-ee-o-blas-TOE-ma) A fast growing type of brain tumor that occurs in or around the pineal gland, a tiny organ near the center of the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8786] "Abnormal growth, with malignant characteristics, of the cells that comprise the tongue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 [8787] "Malignant neoplasms of the trachea"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8788] "Malignant neoplasms of the trachea"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8789] "A rare entity characterized by localized but destructive growth of a tumor consisting of highly atypical, immature mast cells.(WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8790] "(PLAS-ma-sye-TOE-ma) Cancer of the plasma cells (white blood cells that produce antibodies) that may turn into multiple myeloma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8791] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8792] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8793] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8794] "The reemergence of hypopharyngeal cancer after a period of remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8795] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8796] "Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8797] "Abnormal malignant growth of cells in the ureter (upper urinary tract) without spread to any other region."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8798] "A malignant disease of the lymphatic system that is characterized by painless enlargement of lymph nodes, the spleen, or other lymphatic tissue. It is sometimes accompanied by symptoms such as fever, weight loss, fatigue, and night sweats."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 [8799] "Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 [8800] "Typically this basal cell carcinoma has a nodular growth pattern and contains large amounts of melanin.  The melanin is produced by symbiotic nontumoral proliferating melanocytes. - 2002."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8801] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8802] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8803] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8804] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8805] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8806] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8807] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8808] "Stage IV includes T4b, NO,MO/any T NI, MO/ any T N2 MO,/ any T N3 MO/ any T any N M1 : T4b: Tumor invades the pelvic wall, abdominal wall. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. N3: Metastasis in a lymph node more than 5 cm in greatest dimension. M1: Distant metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8809] "Stage IV includes T4b, NO,MO/any T NI, MO/ any T N2 MO,/ any T N3 MO/ any T any N M1 : T4b: Tumor invades the pelvic wall, abdominal wall. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. N3: Metastasis in a lymph node more than 5 cm in greatest dimension. M1: Distant metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8810] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8811] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8812] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8813] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8814] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8815] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8816] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8817] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8818] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8819] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8820] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8821] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8822] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8823] "A malignant tumor arising from the epithelium of the rectal mucosa.  Most rectal carcinomas are adenocarcinomas; squamous cell carcinomas of the rectum are also seen.  Prognosis depends on tumor stage (depth of wall invasion, lymph node involvement, presence of distal metastases). -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8824] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8825] "A carcinoma arising from the epithelium of the renal parenchyma (renal cell carcinoma) or the renal pelvis (renal pelvis carcinoma).  The vast majority of renal cell carcinomas are adenocarcinomas.  The vast majority of renal pelvis carcinomas are transitional cell carcinomas.  Renal carcinomas usually affect middle aged and elderly adults.  Hematuria, abdominal pain, and a palpable mass are common symptoms. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8826] "Cancer that develops in the lining of the renal tubules, which filter the blood and produce urine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8827] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8828] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8829] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8830] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8831] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8832] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8833] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8834] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8835] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8836] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8837] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8838] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8839] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8840] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8841] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8842] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8843] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8844] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8845] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8846] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8847] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8848] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8849] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8850] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8851] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8852] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8853] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8854] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8855] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8856] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8857] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8858] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8859] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8860] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8861] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8862] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8863] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8864] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8865] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8866] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8867] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8868] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8869] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8870] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8871] "A collection of fluid in the pleural cavity as a result of malignant disease. Malignant pleural effusion fluid often contains free-floating malignant cells. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8872] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8873] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8874] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8875] "(ray-dee-AY-shun fye-BRO-sis) The formation of scar tissue as a result of radiation therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8876] "RAEB: An irreversible and usually progressive reduction in renal function in which both kidneys have been damaged by a variety of diseases to the extent that they are unable to adequately remove the metabolic products from the blood and regulate the body's electrolyte composition and acid-base balance. Chronic kidney failure requires HEMODIALYSIS or surgery, usually KIDNEY TRANSPLANTATION. SYN End Stage Renal Disease (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8877] "RAEB: An irreversible and usually progressive reduction in renal function in which both kidneys have been damaged by a variety of diseases to the extent that they are unable to adequately remove the metabolic products from the blood and regulate the body's electrolyte composition and acid-base balance. Chronic kidney failure requires HEMODIALYSIS or surgery, usually KIDNEY TRANSPLANTATION. SYN End Stage Renal Disease (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8878] "An anomaly, deformity, malformation, impairment, or dysfunction. (On-line Mecial Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8879] "Probably intended to be Acute Myeloid Leukemia following a Myelodysplastic Syndrome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8880] "Deposit; matter deposited by some natural process."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8881] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8882] "Rupture; forcible tearing or disruption of tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8884] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8885] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8886] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8887] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8888] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8889] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8891] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8892] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8893] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8894] "Proliferating Brenner tumor is a Brenner tumor characterised by papillary fronds and nuclear cytologic atypia (pattern resembling that of a low-grade [grades I or II] transitional cell carcinoma of the urinary bladder). --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 [8895] "Borderline Brenner tumor is a Brenner tumor characterised by papillary fronds and nuclear cytologic atypia (pattern resembling that of a grade III transitional cell carcinoma of the urinary bladder ) but stromal invasion cannot be demonstrated. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 [8896] "A genetic condition characterized by short stature, premature aging, sensitivity to light, and possibly deafness and mental retardation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8897] "Highly aggressive carcinomas histologically resembling lung small cell lung carcinomas.  In most cases are associated with carcinoma in situ. --2002"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8898] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8899] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8900] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8901] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8902] "Malignant neoplasm of the pharynx"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8903] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8906] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8907] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8910] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8911] "Benign and malignant neoplasms of the cerebellum that arise from astrocytes.  During childhood the majority are benign pilocytic astrocytomas.  In adults both benign and relatively higher grade forms may occur. The most common presenting symptoms are headache, nausea, vomiting, ataxia of gait or limb, paresis, diplopia, and dizziness. Objective signs include weakness, long tract signs, dysmetria, gait ataxia, papilledema, and nystagmus.  Surgical resection is often curative. (KEV 8-7-99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8912] "A WHO grade I large cystic tumor that occurs almost exclusively in infants, with a prominent desmoplastic stroma having a neuroepithelial population mainly of neoplastic astrocytes. They involve the superficial cerebral cortex and leptomeninges, and often attach to the dura. Although clinically they present as large tumors, they generally have a good prognosis following surgical resection. (Adapted from WHO 2000.) - 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 [8913] "Anaplastic astrocytoma, which corresponds to WHO grade III, is a diffusely infiltrating astrocytoma with focal or dispersed anaplasia, and a marked proliferative potential. Anaplastic astrocytomas arise from low-grade astrocytomas, but are also diagnosed at first biopsy, without indication of a less malignant precursor lesion. They have an intrinsic tendency for malignant progression to glioblastoma. (WHO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 [8914] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8915] "Cancer aggregating among blood relatives.  Does not necessarily imply a genetic inheritance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8916] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8917] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8918] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8919] "A fluid filled sac within the pineal gland. It is usually an incidental finding of no real clinical significance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
 [8920] "Loss of a portion of a chromosome arm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 [8921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8922] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8923] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8924] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8927] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8928] "A period in which the infection is present in the host without producing overt symptoms.  (from Online Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 [8929] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8931] "Melanotic Medulloblastoma (WHO grade IV) is a rare tumor of childhood with a predominant element of small round cells closely resembling classic medulloblastoma and a minor component of melanin-forming neuroepithelial cells. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8932] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8933] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8934] "Small numbers of cancer cells that have spread from the primary tumor to other parts of the body and are too few to be picked up in a screening or diagnostic test."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 [8935] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8936] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8937] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8938] "Dysembryoplastic Neuroepithelial Tumor (WHO grade I) is a benign glial-neuronal neoplasm. It is usually supratentorial, located, generally, in the cortex and occurs in children and young adults with a long-standing history of partial seizures. A histologic hallmark of this tumor is the 'specific glioneuronal element', characterized by columns, made up of bundles of axons, oriented perpendicularly to the cortical surface. (Adapted from WHO.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 [8939] "A combination of two synthetic agents, tegafur and uracil, at a molar ratio of 1:4. Also known as UFT, tegafur is assimilated by cancer cells and is metabolized to the active drug 5 fluorouracil (5-FU).  The uracil component interacts with tegafur and inhibits the breakdown of 5-FU, resulting in a higher tumor cell concentration of 5FU than when tegafur is given alone. 5-FU cytotoxicity is related to the activity of 5-fluoro-deoxyuridine-monophosphate (FdUMP), the active metabolite of 5-FU, which competes with deoxyuridine-monophosphate (dUMP), thereby inhibiting thymidylate synthase and DNA synthesis.  Another active 5-FU metabolite, 5-fluorouridine-triphosphate (FUTP), integrates into RNA, thereby inhibiting RNA function. (NCI04)"                                                                                                                                                                                                                              
 [8940] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8941] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8942] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8943] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8944] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8945] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8946] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8948] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8949] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8950] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8951] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8952] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8953] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8954] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8955] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8956] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8957] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8958] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8960] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8961] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8963] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8965] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8966] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8968] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8969] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8970] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8971] "A combination antineoplastic therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 [8972] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8973] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8974] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8975] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8976] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8977] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8979] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8980] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8981] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8982] "A first-generation combination chemotherapy comprised of the drugs cyclophosphamide (C), hydroxydaunomycin (H) , vincristine (O) , and prednisone or its active metabolite prednisolone (P). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 [8983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8984] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8985] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8986] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8988] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8991] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8993] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8994] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8995] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8998] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [8999] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [9000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [9001] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [9002] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [9003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [9004] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [9005] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [9006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [9007] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [9008] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [9009] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [9010] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 [9011] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[10812] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10813] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10814] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10815] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[10821] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10822] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10823] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10824] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10825] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10826] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10827] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10828] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[10834] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10835] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10836] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10837] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10838] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10839] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10840] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10841] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10842] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10843] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10844] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10845] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10846] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10847] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10848] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10849] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10850] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10851] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10852] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10853] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10854] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10855] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10856] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10857] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10858] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10859] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10860] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10861] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10862] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10863] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10864] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10865] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10866] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10867] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10868] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10869] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10870] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10871] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10872] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10873] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10874] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10875] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10876] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10877] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10878] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10879] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10880] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10881] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10882] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10884] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10885] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10886] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10887] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10888] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10889] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10891] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10892] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10893] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10894] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10895] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10896] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10897] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10898] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10899] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10900] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10901] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10902] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10903] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10906] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10907] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10910] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10911] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10912] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10913] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10914] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10915] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10916] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10917] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10918] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10919] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10920] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10922] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10923] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10924] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10927] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10928] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10929] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10932] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10933] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10934] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10935] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10936] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10937] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10938] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10939] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10940] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10941] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10942] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10943] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10944] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10945] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10946] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10948] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10949] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10950] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10951] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10952] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10953] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10954] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10955] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10956] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10957] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10958] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10960] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10961] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10963] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10965] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10966] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10968] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10969] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10970] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10971] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10972] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10973] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10974] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10975] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10976] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10977] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10979] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10980] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10981] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10982] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10984] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10985] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10986] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10988] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10991] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10993] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10994] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10995] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10998] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[10999] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11001] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11002] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11004] "A cancer vaccine based on the immunogenic ganglioside GM2, The GM2-KLH Vaccine/QS21 vaccine consists of GM2 conjugated with KLH keyhole limpet hemocyanin (KLH), a potent immunostimulant, and is admixed with the adjuvant QS21, a saponin fraction extracted from the bark of the South American tree Quillaja saponaria Molina. GM2 is a cell surface carbohydrate antigen expressed by most melanoma cells and various other tumor cell types. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[11005] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11007] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11008] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11009] "Orzel, also called UFT, is an oral formulation of uracil (U) and Tegafur (FT), a prodrug that breaks down to 5-FU and releases it slowly."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11010] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11011] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11012] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11013] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11014] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11015] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11016] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11017] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11018] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11019] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11020] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11021] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11022] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11023] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11024] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[11191] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11192] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11193] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11194] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11195] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11196] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11197] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11198] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11199] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11200] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11201] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11202] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11203] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11204] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11205] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11206] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11207] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11208] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11209] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11210] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11211] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11212] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11213] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11214] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11215] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11216] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11217] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11218] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11219] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11220] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11221] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11222] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11223] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11224] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11225] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11226] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11227] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11228] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11229] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11230] "A chemotherapy combination used in the treatment of cancers such as multiple myeloma and consisting of dexamethasone (antiinflammatory), cisplatin, Dexamethasone, cyclophosphamide, etoposide (cytostatic) and thalidomide (antiangiogenic). (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[11231] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11232] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11233] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11234] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11235] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11236] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11237] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11238] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11239] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11240] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11241] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11242] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11243] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11244] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11245] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11246] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11247] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11248] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11249] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11250] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11251] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11252] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11253] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11254] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11255] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11256] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11257] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11258] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11259] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11261] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11262] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11263] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11264] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11265] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11266] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11267] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11268] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11269] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11270] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11272] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11273] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11274] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11276] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11277] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11278] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11279] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11280] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11281] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11282] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11283] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11284] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11285] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11286] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11287] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11288] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11289] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11290] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11291] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11292] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11293] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11294] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11295] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11296] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11297] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11298] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11299] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11300] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11301] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11302] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11303] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11304] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11305] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11306] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11307] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11308] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11309] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11310] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11311] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11312] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11313] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11314] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11315] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11316] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11317] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11318] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11319] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11320] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11321] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11322] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11323] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11324] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11325] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11326] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11327] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11328] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11329] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11330] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11331] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11332] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11333] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11334] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11335] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11336] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11337] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11338] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11339] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11340] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11341] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11342] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11343] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11344] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11345] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11346] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11347] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11348] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11349] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11350] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11351] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11352] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11353] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11354] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11355] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11356] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11357] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11358] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11359] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[11511] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11512] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11513] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11515] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11516] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11517] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11518] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11519] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11522] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11523] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11524] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11526] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11527] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11529] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11531] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11534] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11535] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11536] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11537] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11538] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11539] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11540] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11541] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11542] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11543] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11544] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11545] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11546] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11547] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11548] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11549] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11550] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11551] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11552] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11553] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11554] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11555] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11556] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11557] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11558] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11559] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11560] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11561] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11562] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11563] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11564] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11565] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11566] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11568] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11569] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11570] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11571] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11572] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11573] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11574] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11575] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11576] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11577] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11578] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11579] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11580] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11581] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11582] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11583] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11584] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11585] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11586] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11587] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11588] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11589] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11590] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11591] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11592] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11593] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11594] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11595] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11596] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11597] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11598] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11599] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11600] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11601] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11602] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11603] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11604] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11605] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11607] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11608] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11609] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11610] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11611] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11612] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11613] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11614] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11615] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11616] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11617] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11618] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11619] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11620] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11621] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11622] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11623] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11624] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11625] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11626] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11627] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11628] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11629] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11630] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11631] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11632] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11633] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11634] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11635] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11636] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11637] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11638] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11639] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11640] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11641] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11642] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11643] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11644] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11645] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11646] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11647] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11648] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11649] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11650] "A tablet formulation comprised of GW776, a Dihydropyrimidine Dehydrogenase (DPD) inhibitor, and 5-Fluorouracil (5-FU), in a 10:1 ratio, developed to block degradation of 5-FU in the gastrointestinal tract by inhibiting DPD, the rate limiting enzyme in 5-FU catabolism, causing increased bioavailability and exposure to 5-FU.  Clinical Trial: Colorectal Cancer.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11651] "Drug therapy with two or more drugs given separately for a combined effect. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11652] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11653] "Either of the two fleshy, full-blooded margins of the mouth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[11654] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11655] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11656] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11657] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11658] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11659] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11660] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11661] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11662] "(PAL-et) The roof of the mouth. The front portion is bony (hard palate), and the back portion is muscular (soft palate)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[11663] "The anteriorly located rigid section of the PALATE."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11664] "A movable fold suspended from the posterior border of the hard palate. The uvula hangs from the middle of the lower border."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11665] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11666] "One of two salivary glands in the neck, located in the space bound by the two bellies of the digastric muscle and the angle of the mandible. It discharges through the submandibular duct. The secretory units are predominantly serous although a few mucous alveoli, some with serous demilunes, occur. (Stedman, 25th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[11667] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11668] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11669] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11670] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11671] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11672] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11673] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11674] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11675] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11676] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11677] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11678] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11679] "The bottom part of the throat. Cancer of the hypopharynx is also called hypopharyngeal cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[11680] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11681] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11682] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11683] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11684] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11685] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11686] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11687] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11688] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11689] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11690] "The superior portion of the body of the stomach above the level of the cardiac notch."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[11691] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11692] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11693] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11694] "not classifiable to C16.1 to C16.4"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[11695] "not classifiable to C16.0 to C16.4"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[11696] "(doo-ah-DEE-num) The first part of the small intestine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[11697] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11698] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11699] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11700] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11701] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11702] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11703] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11704] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11705] "A system of ducts in the pancreas. Pancreatic juices containing enzymes are released into these ducts and flow into the small intestine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[11706] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11707] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11708] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11709] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11710] "The paired, mucosal lined air spaces located above the orbit and communicating with the nasal passages."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[11711] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11712] "(SOO-pra-GLOT-is) The upper part of the larynx (voice box), including the epiglottis; the area above the vocal cords."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[11713] "(SUB-glot-is) The lowest part of the larynx; the area from just below the vocal cords down to the top of the trachea."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[11714] "The nine cartilages of the larynx, including the cricoid, thyroid and epiglottic, and two each of arytenoid, corniculate and cuneiform."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[11715] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11716] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11717] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11718] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11719] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11720] "excludes mandible C41.1"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[11721] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11722] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11723] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11724] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11725] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11726] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11727] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11728] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11729] "The space bounded laterally by the borders of the quadratus lumborum muscles and extends from the diaphragm to the brim of the true pelvis, where it continues as the pelvic extraperitoneal space. (from MeSH)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[11730] "The pigmented projection on the surface of the breast. Ducts that conduct milk from the mammary glands to the surface of the breast exit through the nipple. (from MedTerms Medical Dictionary; medterms.com)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11731] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11732] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11733] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11734] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11735] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11736] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11737] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11738] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11739] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11740] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11741] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11742] "(SER-viks) The lower, narrow end of the uterus that forms a canal between the uterus and vagina."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11743] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11744] "(en-do-MEE-tree-um) The layer of tissue that lines the uterus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[11745] "(mye-o-MEE-tree-um) The muscular outer layer of the uterus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11746] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11747] "The Corpus uteri, or body of uterus, is the part of the uterus above the isthmus, comprising about two thirds of the non-pregnant organ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[11748] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11749] "A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[11750] "A fibromuscular band that attaches to the uterus and then passes along the broad ligament, out through the inguinal ring, and into the labium majus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[11751] "The connective tissue of the pelvic floor extending from the fibrous subserous coat of the supracervical portion of the uterus laterally between the layers of the broad ligament. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[11752] "The appendages of the UTERUS: the FALLOPIAN TUBES, OVARIES, and supporting ligaments of the uterus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11753] "The excretory organ of the embryo, collective Wolffian tubules, which forms the urogenital fold from which the reproductive organs develop. The mesonephros is the permanent kidney in fish and amphibians, but atrophies in reptiles, birds, and mammals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[11754] "A covering fold of skin, often used alone to designate the preputium penis. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[11755] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11756] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11757] "A condition in which one or both testicles fail to move from the abdomen, where they develop before birth, into the scrotum. Undescended testicles may increase the risk for development of testicular cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[11758] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11759] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11760] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11761] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11762] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11763] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11764] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11765] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11766] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11767] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11768] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11769] "(YOU-rah-kus) A fibrous cord that connects the urinary bladder to the umbilicus (navel).  The urachus is formed as the allantoic stalk during fetal development and lasts through life.  Also called the median umbilical ligament."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11770] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11771] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11772] "A membrane that lines the inner surface of the eyelid and also covers the front part of the eye.  Conjunctivitis is inflammation of the conjunctiva."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[11773] "The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous epithelium, Bowman's membrane, stroma, Descemet's membrane, and mesenchymal endothelium. It serves as the first refracting medium of the eye. It is structurally continuous with the sclera, is avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the trigeminal nerve via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses."                                                                                                                                                                                                                                                                                                                                                                                                                          
[11774] "The light-receptive, innermost, nervous tunic of the eye which represents the terminal expansion of the optic nerve. It is a thin, transparent membrane lying between the vitreous body and the choroid and extending from the optic disk to the ciliary body, where it becomes continuous with the inner epithelium of the ciliary body. Grossly, the retina is composed of an outer, pigmented layer and an inner, transparent layer which comprises nine layers. (From Cline et al., Dictionary of Visual Science, 4th ed & Dorland, 27th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11775] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11776] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11777] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11778] "The bony cavity of the skull which contains the eye, anterior portion of the optic nerve, ocular muscles and ocular adnexa.  Seven bones contribute to the structure of the orbit: the frontal, maxillary, zygomatic, sphenoid, lacrimal, ethmoid, and palatine bones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[11779] "(meh-NIN-jeez) The three membranes that cover and protect the brain and spinal cord."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[11780] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11781] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11782] "(seh-REE-bral HEM-iss-feer) One half of the cerebrum, the part of the brain that controls muscle functions and also controls speech, thought, emotions, reading, writing, and learning. The right hemisphere controls the muscles on the left side of the body, and the left hemisphere controls the muscles on the right side of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11783] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11784] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11785] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11786] "Posterior part of the cerebral hemisphere."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[11787] "The ventricles of the brain are four connected cavities (hollow spaces) centrally located within the brain that connect posteriorly with the central cannal of the spinal cord.  All of these spaces are developmentally derived from the central cannal of the embryonic neural tube."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[11788] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11789] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11790] "Any lymph node within the thoracic cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[11791] "Any lymph node within the abdomen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[11792] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11793] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11794] "Any lymph node within the pelvic region."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[11795] "The extraembryonic membrane which contains the EMBRYO and AMNIOTIC FLUID."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11796] "Bone; a rigid connective tissue that makes up the skeleton of vertebrates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[11797] "Having to do with the breast."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11798] "(a-REE-o-la) The area of dark-colored skin on the breast that surrounds the nipple."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11799] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11800] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11801] "The main substance of the muscular wall of the heart enclosed between the epicardium and endocardium.(Webster's Revised Unabridged Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[11802] "is a blood vessel of macroscopic dimensions, the lumen of which is continuous with the ventricles of the heart, directly or indirectly through branches of the aorta and pulmonary trunk. Example(s): bronchial artery, renal artery, anterior interventricular branch of left coronary artery, truncus anterior of right pulmonary artery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11803] "(KAR-tih-lij) A tough, flexible tissue that lines joints and gives structure to the nose, ears, larynx, and other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[11804] "Supporting tissue that surrounds other tissues and organs. Specialized connective tissue includes bone, cartilage, blood, and fat."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[11805] "(AY-nus) The opening of the rectum to the outside of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[11806] "A tube through which bile passes in and out of the liver."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11807] "(GAWL-blad-er) The pear-shaped organ found below the liver. Bile is concentrated and stored in the gallbladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[11808] "The system that includes the esophagus, stomach, small and large intestine, anus, liver, biliary tract, and pancreas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[11809] "The long, tube-like organ that is connected to the small intestine and rectum. The large intestine removes water and some nutrients and electrolytes from digested food. The remaining material, solid waste called stool, moves through the large intestine to the rectum and leaves the body through the anus. Also called the colon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[11810] "A small, fingerlike pouch that sticks out from the cecum (the first part of the large intestine near the end of the small intestine)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[11811] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11812] "(KO-lun) The long, tube-like organ that is connected to the small intestine and rectum. The colon removes water and some nutrients and electrolytes from digested food. The remaining material, solid waste called stool, moves through the colon to the rectum and leaves the body through the anus. Also called the large intestine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[11813] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11814] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11815] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11816] "The part of the digestive tract that is located between the stomach and the large intestine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[11817] "excludes ileocecal valve C18.0"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[11818] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11819] "(eh-SOF-a-gus) The muscular tube through which food passes from the throat to the stomach."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[11820] "The last 6 inches of the large intestine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11821] "An organ that is part of the digestive system. It helps in the digestion of food by mixing it with digestive juices and churning it into a thin liquid."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[11822] "A large organ located in the upper abdomen. The liver cleanses the blood and aids in digestion by secreting bile."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[11823] "A glandular organ located in the abdomen. It makes pancreatic juices, which contain enzymes that aid in digestion, and it produces several hormones, including insulin. The pancreas is surrounded by the stomach, intestines, and other organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11824] "The organ of hearing: composed of the external ear, which includes the auricle and the external acoustic, or auditory, meatus; the middle ear, or the tympanic cavity with its ossicles; and the internal ear or inner ear, or labyrinth, which includes the semicircular canals, vestibule, and cochlea. SEE ALSO auricle. SYN auris."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[11825] "The part of the internal ear that is concerned with hearing. It forms the anterior part of the labyrinth, is conical, and is placed almost horizontally anterior to the vestibule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[11826] "The outer layer of the adrenal gland. It secretes mineralocorticoids, androgens, and glucocorticoids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[11827] "The inner part of the adrenal gland; it synthesizes, stores and releases catecholamines."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[11828] "(PIN-ee-al) A tiny organ in the cerebrum that produces melatonin. Also called pineal body or pineal organ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[11829] "(pih-TOO-ih-tair-ee) The main endocrine gland. It produces hormones that control other glands and many body functions, especially growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11830] "(THIGH-royd) A gland located beneath the voice box (larynx) that produces thyroid hormone. The thyroid helps regulate growth and metabolism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[11831] "1. The organ of vision that consists of the eyeball and the proximal portion of the optic nerve; SYN oculus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[11832] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11833] "(fa-LO-pee-in) Part of the female reproductive tract. The long slender tubes through which eggs pass from the ovaries to the uterus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[11834] "(O-va-reez) The pair of female reproductive glands in which the ova, or eggs, are formed. The ovaries are located in the pelvis, one on each side of the uterus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11835] "(YOO-ter-us) The small, hollow, pear-shaped organ in a woman's pelvis. This is the organ in which a fetus develops. Also called the womb."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11836] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11837] "(vah-JYE-na) The muscular canal extending from the uterus to the exterior of the body. Also called the birth canal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11838] "The external female genital organs, including the clitoris, vaginal lips, and the opening to the vagina."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[11839] "An external male reproductive organ. It contains a tube called the urethra, which carries semen and urine to the outside of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[11840] "(PROS-tate) A gland in the male reproductive system just below the bladder.  The prostate surrounds part of the urethra, the canal that empties the bladder, and produces a fluid that forms part of semen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11841] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11842] "(TES-tih-kuls) The two egg-shaped glands found inside the scrotum. They produce sperm and male hormones.  Also called testes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11843] "(YOO-rin-air-ee) The organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11844] "A distensible musculomembranous organ serving as a receptacle for fluid, as the gallbladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[11845] "(KID-neez) A pair of organs in the abdomen that remove waste from the blood (as urine), produce erythropoietin (a substance that stimulates red blood cell production), and play a role in blood pressure regulation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[11846] "(yoo-REE-ter) The tube that carries urine from the kidney to the bladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11847] "(yoo-REE-thra) The tube through which urine leaves the body. It empties urine from the bladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[11848] "For oncology, area of the body generally construed to comprise base of skull and facial bones, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature and lymph nodes draining these areas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[11849] "The anterior or superior part of an animal, containing the brain, or chief ganglia of the nervous system, the mouth, and in the higher animals, the chief sensory organs. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[11850] "(LAIR-inks) The area of the throat containing the vocal cords and used for breathing, swallowing, and talking. Also called the voice box."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11851] "The cavity lying at the upper end of the alimentary canal, bounded on the outside by the lips and inside by the oropharynx and containing in humans the tongue, gums, and teeth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11852] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11853] "(NAY-zo-fair-inks) The upper part of the throat behind the nose. An opening on each side of the nasopharynx leads into the ear."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[11854] "The proximal portion of the respiratory passages on either side of the nasal septum, lined with ciliated mucosa, extending from the nares to the pharynx."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11855] "(FAIR-inks) The hollow tube about 5 inches long that starts behind the nose and ends at the top of the trachea (windpipe) and esophagus (the tube that goes to the stomach)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[11856] "(SAL-ih-vair-ee) Glands in the mouth that produce saliva."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11857] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11858] "(TRAY-kee-uh) The airway that leads from the larynx to the lungs. Also called the windpipe."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11859] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11860] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11861] "The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[11862] "An organ that is part of the lymphatic system. The spleen produces lymphocytes, filters the blood, stores blood cells, and destroys old blood cells. It is located on the left side of the abdomen near the stomach."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[11863] "An organ that is part of the lymphatic system, in which T lymphocytes grow and multiply. The thymus is in the chest behind the breastbone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[11864] "Blood circulating throughout the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[11865] "Muscle Tissue; an animal tissue consisting predominantly of contractile cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[11866] "Striated muscles are appendicular and axial muscles typically connected at either or both ends to the bony skeleton of the body.  Striated muscle fibers contain a highly organized, contractile cytoskeletal apparatus with a striated microscopic appearance; muscle contraction is typically under voluntary control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[11867] "Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11868] "The brain and spinal cord."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[11869] "That part of the central nervous system contained within the cranium, comprising the prosencephalon, mesencephalon, and rhombencephalon. It is derived from the anterior part of the embryonic neural tube. Functions include muscle control and coordination, sensory reception and integration, speech production, memory storage, and the elaboration of thought and emotions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[11870] "Almond-shaped group of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe. The amygdala is part of the limbic system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11871] "The part of the brain that is connected to the spinal cord."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11872] "The lower portion of the brainstem located between the pons and brainstem.  This structure contains several descending and ascending tracts, lower cranial nerve nuclei, a significant proportion of the reticular system of the brainstem and other structures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11873] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11874] "a layer of gray matter lying along the floor of the lateral ventricle of the brain, comprised of cholinergic and possibly glutamatergic fibers, believed to be the critical brain structure underlying learning and memory."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11875] "(sair-uh-BELL-um) The portion of the brain in the back of the head between the cerebrum and the brain stem. The cerebellum controls balance for walking and standing, and other complex motor functions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[11876] "the main neocortical commissure of the cerebral hemispheres; it is subdivided into a genu, a rostrum, a body, and a splenium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11877] "Large subcortical nuclear masses derived from the telencephalon and located in the basal regions of the cerebral hemispheres."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11878] "Striped gray and white matter consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the thalamus in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The white matter is the internal capsule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[11879] "The representation of the phylogenetically oldest part of the corpus striatum called the paleostriatum. It forms the smaller, more medial part of the lentiform nucleus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[11880] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11881] "Elongated gray mass of the neostriatum located adjacent to the lateral ventricle of the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[11882] "The largest and most lateral of the basal ganglia lying between the lateral medullary lamina of the globus pallidus and the external capsule. It is part of the neostriatum and forms part of the lentiform nucleus along with the globus pallidus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11884] "Lens-shaped structure on the inner aspect of the internal capsule. The subthalamic nucleus and pathways traversing this region are concerned with the integration of somatic motor function. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p52)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[11885] "The part of the brain developed from the most rostral of the three primary vesicles of the embryonic neural tube and consisting of the DIENCEPHALON and TELENCEPHALON."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[11886] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11887] "The dorsal posterior subdivision of the diencephalon. The epithalamus is generally considered to include the habenular nuclei (HABENULA) and associated fiber bundles, the PINEAL BODY, and the epithelial roof of the third ventricle. The anterior and posterior paraventricular nuclei of the thalamus are included with the THALAMIC NUCLEI although they develop from the same pronuclear mass as the epithalamic nuclei and are sometimes considered part of the epithalamus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11888] "(hye-po-THAL-uh-mus) The area of the brain that controls body temperature, hunger, and thirst."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[11889] "(THAL-a-muss) An area of the brain that helps process information from the senses and transmit it to other parts of the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[11890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11891] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11892] "Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[11893] "The rod-shaped body, composed of cells derived from the mesoblast and defining the primitive axis of the embryo. In lower vertebrates, it persists throughout life as the main axial support of the body, but in higher vertebrates it is replaced by the vertebral column."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11894] "Spinal Cord; the elongated, approximately cylindrical part of the central nervous system of vertebrates that lies in the vertebral canal and from which the spinal nerves emerge. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[11895] "The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[11896] "Any of the bundles of nerve fibers running to various organs and tissues of the body using chemical and electrical signals to transmit sensory and motor information from one body part to another."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11897] "Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11898] "One of a pair of viscera occupying the pulmonary cavities of the thorax, the organs of respiration in which aeration of the blood takes place. As a rule, the right lung is slightly larger than the left and is divided into three lobes (an upper, a middle, and a lower or basal), while the left has but two lobes (an upper and a lower or basal). Each lung is irregularly conical in shape, presenting a blunt upper extremity (the apex), a concave base following the curve of the diaphragm, an outer convex surface (costal surface), an inner or mediastinal surface (mediastinal surface), a thin and sharp anterior border, and a thick and rounded posterior border. SYN pulmo."                                                                                                                                                                                                                                                                                                     
[11899] "(PLOOR-a) A thin layer of tissue covering the lungs and the wall of the chest cavity to protect and cushion the lungs. A small amount of fluid that acts as a lubricant allows the lungs to move smoothly in the chest cavity during breathing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[11900] "1. An organ and the enveloping membrane of the body; includes, in addition to the epidermis and dermis, all of the derivatives of the epidermis, e.g., hairs, nails, sudoriferous and sebaceous glands, and mammary glands. Subdivisions of the skin surround various body parts; as a whole, the skin constitutes the external surface of the body. 2. The rind, capsule, or covering of any body or part."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11901] "Refers to muscle, fat, fibrous tissue, blood vessels, or other supporting tissue of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11902] "Connective tissue composed of fat cells lodged in the meshes of areolar tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[11903] "The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11904] "Immunologically important lymphocyte that is not thymus-dependent, is either short-lived and naive or long-lived and of memory phenotype, and resembles the bursa-derived lymphocyte of birds in that it is responsible for the production of immunoglobulins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[11905] "(BAY-sal) Small, round cells found in the lower part (or base) of the epidermis, the outer layer of the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11906] "A thymocyte-derived lymphocyte of immunological importance that is long-lived (months to years) and is responsible for cell-mediated immunity. T lymphocyte cells form rosettes with sheep erythrocytes and, in the presence of transforming agents (mitogens), differentiate and divide. These cells have the characteristic T3 surface marker and may be further divided into subsets according to function, such as helper, cytotoxic, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[11907] "(AS-troe-site) A type of cell in the brain and spinal cord. An astrocyte is a small, star-shaped glial cell (a cell that surrounds and supports nerve cells)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11910] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11911] "The layer of epithelial cells that lines the cavities of the heart and of the blood vessels (Endothelium, Vascular) and lymph vessels (Endothelium, Lymphatic), and the serous cavities of the body, originating from the mesoderm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11912] "A connective tissue cell that makes and secretes collagen proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11913] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11914] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11915] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11916] "A type of white blood cell that produces antibodies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[11917] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11918] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11919] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11920] "The supporting connective tissue of an organ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11922] "Within the abdomen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11923] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11924] "The sloping surface from the dorsum sellae to the foramen magnum composed of part of the body of the sphenoid and part of the basal part of the occipital bone. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[11925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11927] "A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11928] "That part of the ear canal external to the ear drum"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11929] "The internal ear; the essential part of the organ of hearing. It consists of an osseous and a membranous portion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[11930] "A tubular structure that runs from the middle ear to the nasopharynx and is approximately 3-4 cm length. Its lumen is roughly triangular and has average diameter of 2-3 mm. The lumen is lined by ciliated pseudostratified, columnar epithelium, which sweeps material from the middle ear to the nasopharynx.  functionally collapsed at rest, with slight negative pressure present in the middle ear. It is closed at rest and opens during swallowing, sneezing, and yawning.  It serves to ventilate pressure differences between the middle ear and nasopharynx. This tube also allows middle ear secretions to drain into the nasopharynx."                                                                                                                                                                                                                                                                                                                                                
[11931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11932] "A thin membrane that separates the external auditory canal from the middle ear.  The movement of the tympanic membrane in response to air pressure changes in the external ear facilitates the transmission of sound energy by causing vibration of the ossicular chain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[11933] "A honeycombed section of bone located near the base of the skull, protruding behind the outer ear.  It is connected to the middle ear."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[11934] "The region consisting of the vestibulum oris, the narrow cleft between the lips and cheeks, and the teeth and gums, and the cavitas oris propria."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[11935] "(BUK-ul myoo-KO-sa) The inner lining of the cheeks and lips."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[11936] "is an organ, the organ parts of which primarily consist of dentine and dental enamel; together with other teeth it constitutes a subdivision of the facial skeleton. Example(s): incisor, molar."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11937] "(MAN-tul) The area of the neck, chest, and lymph nodes in the armpit that are exposed to radiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11938] "The individual unit that makes up all of the tissues of the body. All living things are made up of one or more cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[11939] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11940] "The uppermost portion of the brainstem located between the pons and the diencephalon.  The midbrain contains the cerebral peduncles, oculomotor, trochlear and red nuclei, substantia nigra and various other nuclei and tracts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11941] "Part of the central nervous system, located at the base of the brain, between the medulla oblongata and the midbrain. It is part of the brainstem."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[11942] "(seh-REE-brum) The largest part of the brain. It is divided into two hemispheres, or halves, called the cerebral hemispheres. Areas within the cerebrum control muscle functions and also control speech, thought, emotions, reading, writing, and learning."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[11943] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11944] "An intracranial venous sinus that lies in a midline location along the lower free border of the falx cerebri of the brain. The sinus receives blood from the great cerebral vein and joins the superior sagittal sinus posteriorly."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11945] "An intracranial venous sinus that lies in a superior and midline location above the interhemispheric fissure along the superior border of the falx cerebri of the brain. The sinus receives blood from the cerebral veins and drains posteriorly into the lateral sinuses of the brain, which in turn drain into the internal jugular veins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[11946] "The brain, intracranial portions of the cranial nerves, intracranial blood vessels, intracranial meninges and other surrounding and supporting structures contained with the skull cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[11947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11948] "The undifferentiated cells formed by cleavage of the fertilized ovum. This includes cells in the cleavage, morula, and blastula stages of the embryo."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[11949] "A general term describing the three cellular components of blood (white blood cells, red blood cells, and platelets), all which are made in the bone marrow. (Lymphoma Information Network Glossary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[11950] "Blood cells that help prevent bleeding by causing blood clots to form."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[11951] "(eh-RITH-ro-sites) Cells that carry oxygen to all parts of the body. Also called red blood cells (RBCs)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[11952] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11953] "Erythrocytes with protoplasmic projections giving the cell a thorny appearance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[11954] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11955] "Small, abnormal spherical red blood cells with more than the normal amount of hemoglobin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11956] "Committed, erythroid stem cells derived from myeloid stem cells. The progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E). BFU-E differentiate into CFU-E on stimulation by erythropoietin, and then further differentiate into erythroblasts when stimulated by other factors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11957] "Erythroblast; a nucleated cell of the bone marrow from which red blood cells develop."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[11958] "Immature ERYTHROCYTES. In humans, these are erythroid cells that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic \"reticulum\" (not the same as the endoplasmic reticulum), hence the name reticulocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[11959] "(LOO-ko-sites) White blood cell. Refers to a blood cell that does not contain hemoglobin. White blood cells include lymphocytes, neutrophils, eosinophils, macrophages, and mast cells. These cells are made by bone marrow and help the body fight infection and other diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[11960] "A leucocyte with conspicuous cytoplasmic granules. In humans the granulocytes are also classified as polymorphonuclear leucocytes and are subdivided according to the staining properties of the granules into eosinophils, basophils and neutrophils. (from On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[11961] "A type of white blood cell. Basophils are granulocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[11962] "A type of white blood cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11963] "(NOO-tro-fil) A type of white blood cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11964] "(A-gran-yoo-lo-SITE) A type of white blood cell; monocytes and lymphocytes are agranulocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11965] "(LIM-fo-site) A type of white blood cell. Lymphocytes have a number of roles in the immune system, including the production of antibodies and other substances that fight infection and diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[11966] "Natural killer cells are cells that resemble large granular lymphocytes.  They do not express markers of either T or B cell lineage. They are positive for CD16, CD56, and CD 94.  These cells do possess Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity. They can also use perforin to kill cells in the absence of antibody and killing may occur without previous sensitization."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[11967] "A type of white blood cell that helps stimulate immune system reactions.  Helper T cells help activate cytotoxic T cells and macrophages by secreting cytokines. They also stimulate B cells to make antibodies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11968] "Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[11969] "Type 1 Helper Cells are a subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, these cells are associated with delayed-type hypersensitivity reactions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[11970] "Type 2 Helper Cells are a subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11971] "Subpopulation of CD4+ lymphocytes which induce CD8+ suppressor T-cells (T-LYMPHOCYTES, SUPPRESSOR-EFFECTOR) to suppress antibody production by B-cells. They also stimulate other cellular immune responses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[11972] "A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and suppressor T-lymphocytes (T-LYMPHOCYTES, SUPPRESSOR-EFFECTOR)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11973] "A type of white blood cell that can directly destroy specific cells. T cells can be separated from other blood cells, grown in the laboratory, and then given to a patient to destroy tumor cells. Certain cytokines can also be given to a patient to help form cytotoxic T cells in the patient's body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11974] "Subpopulation of CD8+ T-lymphocytes which suppress antibody production or inhibit cellular immune responses. Suppressor-effector cells execute the message received from suppressor-inducer cells (T-LYMPHOCYTES, SUPPRESSOR-INDUCER)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[11975] "A class of lymphocytes characterized by the lack of surface markers specific for either T or B lymphocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11976] "Lymphocytes that show specificity for autologous tumor cells. Ex vivo isolation and culturing of TIL with interleukin-2, followed by reinfusion into the patient, is one form of adoptive immunotherapy of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[11977] "A type of white blood cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[11978] "Monocytes made cytotoxic by ex vivo incubation with cytokines, especially interferon-gamma. AKM cells are used for adoptive immunotherapy in cancer patients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11979] "Cells which include the MONOCYTES and the GRANULOCYTES."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[11980] "Cells contained in the bone marrow including fat cells (see ADIPOCYTES), STROMAL CELLS, MEGAKARYOCYTES, and the immediate precursors of most blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[11981] "Primitive blood cells derived from embryonic mesenchyme capable of differentiating into any of the blood cell line progenitor cells (erythroblasts, young granulocytic series cells, megakaryocytes, etc.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[11982] "One of the two stem cells derived from HEMATOPOIETIC STEM CELLS - the other being the lymphoid progenitor cell. Derived from these myeloid progenitor cells are the ERYTHROID PROGENITOR CELLS and the MYELOID CELLS (MONOCYTES and GRANULOCYTES)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[11983] "Very large bone marrow cells which release mature blood platelets."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[11984] "Cells that store epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia (PARAGANGLIA, CHROMAFFIN) of the sympathetic nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11985] "A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[11986] "Fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue. Fat is usually stored in the form of TRYGLYCERIDES."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11987] "Cartilage cells.  They make the structural components of cartilage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[11988] "A type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[11989] "Characteristic cells of granulomatous hypersensitivity. They appear as large, flattened cells with increased endoplasmic reticulum. They are believed to be activated macrophages that have differentiated as a result of prolonged antigenic stimulation. Further differentiation or fusion of epithelioid cells is thought to produce multinucleated giant cells (GIANT CELLS)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[11990] "Lipid-laden macrophages originating from monocytes or from smooth muscle cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[11991] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11993] "A macrophage present in connective tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[11994] "Large star-shaped or pyramidal cells with a large oval nucleus and a small prominent nucleolus. These intensely phagocytic cells line the walls of the sinusoids of the liver and form a part of the reticuloendothelial system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11995] "Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[11996] "Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[11997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[11998] "Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[11999] "Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12000] "A large multinuclear cell associated with the absorption and removal of bone. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in cementum resorption."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12001] "Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12002] "The connective tissue cells of the ovarian follicle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12003] "Cells found throughout the lining of the gastrointestinal tract that contain regulatory peptide hormones and/or biogenic amines. The substances are located in secretory granules and act in an endocrine or paracrine manner. Some of these substances are also found in neurons in the gut. There are at least 15 different types of endocrine cells of the gut. Some take up amine precursors and have been called APUD CELLS. However, most endocrine cells of the gut apparently have endodermal rather than neuroectodermal origin, so the relationship with APUD cells is not clear."                                                                                                                                                                                                                                                                                                                                                                                                        
[12004] "Cells found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12005] "Group of basal granular cells of the gut whose granules stain readily with silver and chromium salts. The cells secrete serotonin, substance P, and enkephalins. There are three types: gastric (antral mucosa), duodenal, and intestinal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12006] "Irregular-shaped argyrophilic cells which produce histamine, chromogranin A/pancreastatin, and an as yet unidentified peptide hormone. They are the predominant endocrine cell type of the oxyntic (acid-producing) mucosa of the stomach. ECL cells respond to gastrin by releasing their secretory products and this source of histamine acts as the positive paracrine stimulator of the release of hydrochloric acid from the parietal cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12007] "Endocrine cells found in the pyloric gland mucosa (antral mucosa) of the stomach and responsible for the secretion of gastrin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12008] "Cells that cover the surface of the body and line its cavities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12009] "Cylindrical epithelial cells in the innermost layer of the ENAMEL ORGAN. Their functions include contribution to the development of the dentinoenamel junction by the deposition of a layer of the matrix, thus producing the foundation for the prisms (the structural units of the DENTAL ENAMEL), and production of the matrix for the enamel prisms and interprismatic substance. (From Jablonski's Dictionary of Dentistry, 1992)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12010] "Epithelial cells that line the basal half of the gastric glands. Chief cells synthesize and secrete pepsinogen, a precursor of the enzyme pepsin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12011] "The large pigment cells of fish, amphibia, reptiles and many invertebrates which actively disperse and aggregate their pigment granules. These cells include MELANOPHORES, erythrophores, xanthophores, leucophores and iridiophores. (In algae, chromatophores refer to CHLOROPLASTS. In phototrophic bacteria chromatophores refer to membranous organelles (BACTERIAL CHROMATOPHORES.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12012] "Chromatophores (large pigment cells of fish, amphibia, reptiles and many invertebrates) which contain melanin. Short term color changes are brought about by an active redistribution of the melanophores pigment containing organelles (MELANOSOMES). Mammals do not have melanophores; however they have retained smaller pigment cells known as MELANOCYTES."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12013] "A special type of antigen-presenting cell (APC) that activates T lymphocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12014] "Dendritic clear cells in the epidermis, containing distinctive granules that appear rod- or racket-shaped in section, but lacking tonofilaments, melanosomes, and desmosomes; they carry surface receptors for immunoglobulin (Fc) and complement (C3), and are believed to be antigen fixing and processing cells of monocytic origin; active participants in cutaneous delayed hypersensitivity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12015] "Terminally differentiated cells comprising the majority of the external surface of the intestinal epithelium (see INTESTINAL MUCOSA). Unlike GOBLET CELLS, they do not produce or secrete mucins, nor do they secrete cryptdins as do the PANETH CELLS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12016] "Cells of the epithelial lining that produce and secrete mucins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12017] "Cells of the membrana granulosa lining the vesicular ovarian follicle which become luteal cells after ovulation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12018] "(HEP-a-toe-site) A liver cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12019] "Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12020] "Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12021] "(mel-AN-o-sites) Cells in the skin and eyes that produce and contain the pigment called melanin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12022] "Modified epidermal cells located in the stratum basale. They are found mostly in areas where sensory perception is acute, such as the fingertips. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber. Do not confuse with Merkel's corpuscle which is a combination of a neuron and and epidermal cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12023] "Epithelial cells found in the basal part of the intestinal glands (crypts of Lieberkuhn). Paneth cells synthesize and secrete lysozyme and cryptdins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12024] "Cells of the gastric glands which secrete hydrochloric acid and intrinsic factor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12025] "Elongated cells in the seminiferous tubules to which spermatids are attached during spermiogenesis; they secrete androgen-binding protein and establish the blood-testis barrier by forming tight junctions with adjacent Sertoli's cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12026] "Cells of the higher organisms, containing a true nucleus bounded by a nuclear membrane."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12027] "A reproductive cell of the body. Germ cells are egg cells in females and sperm cells in males."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12028] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12029] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12030] "The primitive differentiated female gametes which give rise to oocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12031] "The cell formed by the union of two gametes, especially a fertilized ovum before cleavage. (Online Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12032] "The fluid the sperm is suspended in; it originates from the testis and the prostate"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12033] "The anterior, usually ovoid, nucleus-containing part of spermatozoa."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12034] "Male germ cells derived from spermatocytes and developing into spermatozoa."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12035] "Male germ cells derived from spermatogonia and developing into spermatids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12036] "The primitive differentiated male gametes which give rise to spermatocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12037] "A large cell-like structure formed by the joining together of two or more cells.  The plural is syncytia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12038] "(EYE-lets of LANG-er-hanz) Cells in the pancreas that produce hormones (including insulin)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12039] "Cells in the interstitial tissue of the testis that are believed to furnish the internal secretion of that gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12040] "The cells of the corpus luteum which are derived from the granulosa cells and the theca cells of the Graafian follicle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12041] "Cells of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B-lymphocytes, can be defined, based on the different classes of immunoglobulins that they synthesize."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12042] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12043] "Skeletal muscle fibers having high myofibrillar ATPase activity, high glycolytic enzyme activities, and an intermediate glycogen content which produce a fast twitch. There are two types. Fast fatigable fibers, also called white fibers, have a low myoglobin content, and a small mitochondrial content, and fatigue rapidly due to their limited glycogen content and low capacity for oxidative metabolism. Fast fatigue-resistant fibers, also called red fibers, have a large mitochondrial content and a high myoglobin content, related to their resistance to fatigue. (From Best, Physiological Basis of Medical Practice, 12th ed, p100)"                                                                                                                                                                                                                                                                                                                                              
[12044] "Skeletal muscle fibers having low myofibrillar ATPase activity, low glycogen content, and high myoglobin content, high mitochondrial oxidative enzyme activities, and an intermediate mitochondrial content which produce a slow twitch and are fatigue-resistant. (From Best, Physiological Basis of Medical Practice, 12th ed, p101)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12045] "(GLEE-al) A type of cell that surrounds nerve cells and holds them in place.  Glial cells also insulate nerve cells from each other."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12046] "The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling."                                                                                                                                                                                                                                                                                                                     
[12047] "A dense intricate feltwork of interwoven fine glial processes, fibrils, synaptic terminals, axons, and dendrites interspersed among the nerve cells in the gray matter of the central nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12048] "A class of neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal satellite cells according to their location. The most important recognized function of these cells is the formation of the insulating myelin sheaths of axons in the central nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12049] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12050] "A type of glial cell of the peripheral nervous system that helps separate and insulate nerve cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12051] "APC. A cell that shows antigen on its surface to other cells of the immune system. This is an important part of an immune response."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12052] "Antigen Presenting Cells (APCs) located in the follicles of secondary lymphoid organs.  These dendritic cells are unique because of their location, primarily in lymphoid follicles, and because of their function in retaining antigen molecules for extended periods of time and serving as APCs for B cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12053] "A type of cell that receives and sends messages from the body to the brain and back to the body. The messages are sent by a weak electrical current.  Also called a nerve cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12054] "Nerve fibers which project from the central nervous system to autonomic ganglia. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the spinal cord, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in synapses or continue through the splanchnic nerves to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the brain stem and sacral spinal cord. In both divisions the principal transmitter is acetylcholine but peptide cotransmitters may also be released."                                                                                                                                                                                                                                                                                                                       
[12055] "Most generally any neurons which are not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12056] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12057] "AXONS of NEURONS encased in a lipoproteinaceous material called MYELIN. Myelinated nerve fibers conduct impulses more rapidly than unmyelinated nerve fibers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12058] "Neurons which convey sensory information centrally from the periphery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12059] "Mechanoreceptors located in the organ of Corti that are sensitive to auditory stimuli and in the vestibular apparatus that are sensitive to movement of the head. In each case the accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12060] "Bulbous cells that are medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12061] "Mechanoreceptors in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12062] "Mechanoreceptors located in the acoustic maculae and the semicircular canals that mediate the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the VESTIBULOCOCHLEAR NERVE to the brain stem."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12063] "Neurons in the olfactory epithelium with proteins (RECEPTORS, ODORANT) that bind, and thus detect, odorants. Olfactory receptor neurons are bipolar. They send to the surface of the epithelium apical dendrites with non-motile cilia from which project odorant receptor molecules. Their unmyelinated axons synapse in the olfactory bulb of the brain. Unlike other neurons, they can be generated from precursor cells in adults."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12064] "Cells specialized to detect and transduce light."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12065] "Cells in invertebrates which are specialized to detect and transduce light and darkness and relay that information centrally in the nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12066] "Cells specialized to detect and transduce light. Rods and cones are the photoreceptors in the vertebrate retina."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12067] "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12068] "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12069] "Rods are the major photoreceptor cells of the vertebrate retina (about 125 million in a human eye). They are columnar cells having three distinct regions: a region adjacent to and synapsed with, the neural layer of the retina contains the nucleus and other cytoplasmic organelles, below this is the inner segment, rich in mitochondria, that is connected through a thin neck (in which is located a ciliary body) to the outer segment. The outer segment largely consists of a stack of discs (membrane infoldings that are incompletely separated in cones) that are continually replenished near the inner segment and that are shed from the distal end and phagocytosed by the pigmented epithelium. The membranes of the discs are rich in rhodopsin, the pigment that absorbs light. (from On-line Medical Dictionary)"                                                                                                                                                             
[12070] "Neurons in the posterior (dorsal) horn of the spinal cord whose cell bodies and processes are confined entirely to the central nervous system. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to ANTERIOR HORN CELLS or to the white matter ascending and descending longitudinal fibers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12071] "Gelatinous-appearing material in the dorsal horn of the spinal cord, consisting chiefly of Golgi type II neurons and some larger nerve cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12072] "Cells of the innermost nuclear layer of the retina, the ganglion cell layer, which project axons through the optic nerve to the brain. They are quite variable in size and in the shapes of their dendritic arbors, which are generally confined to the inner plexiform layer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12073] "Neurons which send impulses peripherally to activate muscles or secretory cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12074] "Neurons which activate muscle cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12075] "Motor neurons in the anterior (ventral) horn of the spinal cord which project to skeletal muscles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12076] "Motor neurons which activate the contractile regions of intrafusal muscle fibers, thus adjusting the sensitivity of the muscle spindles to stretch. Gamma motor neurons may be \"static\" or \"dynamic\" according to which aspect of responsiveness (or which fiber types) they regulate. The alpha and gamma motor neurons are often activated together (alpha gamma coactivation) which allows the spindles to contribute to the control of movement trajectories despite changes in muscle length."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12077] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12078] "Nerve fibers which project from cell bodies of autonomic ganglia to synapses on target organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12079] "Nerve fibers which project from parasympathetic ganglia to synapses on target organs. Parasympathetic postganglionic fibers use acetylcholine as transmitter. They may also release peptide cotransmitters."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12080] "Nerve fibers which project from sympathetic ganglia to synapses on target organs. Sympathetic postganglionic fibers use norepinephrine as transmitter, except for those innervating eccrine sweat glands (and possibly some blood vessels) which use acetylcholine. They may also release peptide cotransmitters."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12081] "The output neurons of the cerebellar cortex."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12082] "Projection neurons in the cerebral cortex and the hippocampus. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12083] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12084] "Cells derived from primitive cell types in the neural crest. During ontogeny they migrate to the foregut and specific locations of the neuroendocrine system. Properly located these cells form part of the normal hormone producing tissues of the neuroendocrine system. If misdirected these cells may become hyperplastic, adenomatous, or malignant (cf. APUDOMA)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12085] "Slender, contractile, mesenchymal-like cells found in close association with capillary walls. They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells. (From Stedman, 26th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12086] "An immune system cell that can surround and kill microorganisms and remove dead cells. Phagocytes include macrophages."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12087] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12088] "A bacterial cell deprived of its cell wall, for example by growth in an isotonic medium in the presence of antibiotics that block synthesis of the wall peptidoglycan. Alternatively, a plant cell similarly deprived by enzymic treatment. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12089] "A type of cell that appears in people with Hodgkin's disease. The number of these cells increases as the disease advances."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12090] "Cells, usually bacteria or yeast, which have partially lost their cell wall, lost their characteristic shape and become round."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12091] "Cells from which other types of cells can develop."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12092] "Colony-forming cells which give rise to neoplasms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12093] "(AB-do-men) The area of the body that contains the pancreas, stomach, intestine, liver, gallbladder, and other organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12094] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12095] "Suprarenal gland. A flattened, roughly triangular body resting upon the upper end of each kidney; it is one of the ductless glands furnishing internal secretions (epinephrine and norepinephrine from the medulla and steroid hormones from the cortex). SYN glandula suprarenalis, adrenal body, adrenal capsule, adrenal gland, atrabiliary capsule, epinephros, glandula atrabiliaris, paranephros, suprarenal body, suprarenal capsule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12096] "The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12097] "The part of the eye anterior to the lens, including but not limited to the anterior chamber, cornea and related structures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12098] "(a-OR-tuh) The largest artery in the body. It carries oxygen-rich blood away from the heart to vessels that reach the rest of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12099] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12100] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12101] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12102] "The part of the nervous system of vertebrates that controls involuntary actions of the smooth muscles and heart and glands."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12103] "Axilla; the hollow under the arm where it is joined to the shoulder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12104] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12105] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12106] "The bile ducts that pass through and drain bile from the liver."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12107] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12108] "A tube through which the blood circulates in the body.  Blood vessels include a network of arteries, arterioles, capillaries, venules, and veins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12109] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12110] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12111] "(BRAY-kee-ul PLEKS-us) A network of nerves that sends signals from the spine to the arm and hand."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12112] "(BRONK-eye) The large air passages that lead from the trachea (windpipe) to the lungs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12113] "(BRON-kee-olz) The tiny branches of air tubes in the lungs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12114] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12115] "Relating to the heart and the blood vessels or the circulation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12116] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12117] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12118] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12119] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12120] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12121] "(seh-REE-broe-SPY-nal) The fluid flowing around the brain and spinal cord. Cerebrospinal fluid is produced in the ventricles in the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12122] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12123] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12124] "Collar bone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12125] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12126] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12127] "Bile ducts are passageways that carry bile. Two major bile ducts come together into a \"trunk\"-the common bile duct which empties into the upper part of the small intestine (the part next to the stomach)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12128] "The lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12129] "Any of the 12 paired nerves that originate in the brain stem."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12130] "(DER-mis) The lower or inner layer of the two main layers of tissue that make up the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12131] "(DYE-a-fram) The thin muscle below the lungs and heart that separates the chest from the abdomen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12132] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12133] "Ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12134] "Collective designation for those tissues capable of secreting hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12135] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12136] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12137] "(ep-i-DER-mis) The upper or outer layer of the two main layers of tissue that make up the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12138] "(ep-ih-GLAH-tis) The flap that covers the trachea during swallowing so that food does not enter the lungs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12139] "(EP-ih-THEE-lee-um) A thin layer of tissue that covers organs, glands, and other structures within the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12140] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12141] "A gland from which secretions reach a free surface of the body by ducts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12142] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12143] "The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and salivary glands, and convey afferent information for taste from the anterior two-thirds of the tongue and for touch from the external ear."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12144] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12145] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12146] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12147] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12148] "is a macroscopic organ component of one or more nerves, which primarily consists of cell bodies of neurons located outside the central nervous system; together with nerve fibers, it constitutes a nerve or a nerve plexus. Example(s): spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12149] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12150] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12151] "The male reproductive organs. They are divided into the external organs (penis, scrotum, and urethra) and the internal organs (testis, epididymis, ductus deferens, seminal vesicle, ejaculatory duct, prostate, and bulbourethral gland. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12152] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12153] "(GLAH-tis) The middle part of the larynx; the area where the vocal cords are located."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12154] "The gamete-producing glands, OVARY or TESTIS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12155] "The area where the thigh meets the abdomen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12156] "A hollow muscular organ which receives the blood from the veins and propels it into the arteries. It is divided by a musculomembranous septum into two halves -- right or venous and left or arterial -- each of which consists of a receiving chamber (atrium) and an ejecting chamber (ventricle). SYN cor, coeur."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12157] "The paired upper chambers of the heart.  The left atrium receives oxygenated blood from the pulmonary vein and pumps blood into the left ventricle.  The right atrium receives venous deoxygenated blood from the entire body via the superior and inferior vena cavae and pumps blood into the right ventricle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12158] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12159] "The lower right and left chambers of the heart. The right pumps venous blood into the lungs and the left pumps oxygenated blood into the systemic arterial circulation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12160] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12161] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12162] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12163] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12164] "(im-YOON) The complex group of organs and cells that defends the body against infection or disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12165] "(in-TES-tin) The long, tube-shaped organ in the abdomen that completes the process of digestion. There is both a large intestine and a small intestine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12166] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12167] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12168] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12169] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12170] "NK cells. A type of white blood cell that contains granules with enzymes that can kill tumor cells or microbial cells. Also called large granular lymphocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12171] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12172] "A biconvex transparent structure of the eye through which light is focused on the retina.  The lens sits behind the iris and is supported by the zonule, which connects it to the ciliary body.  The lens is an avascular structure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12173] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12174] "(limf node) A rounded mass of lymphatic tissue that is surrounded by a capsule of connective tissue. Lymph nodes filter lymph (lymphatic fluid), and they store lymphocytes (white blood cells). They are located along lymphatic vessels.  Also called a lymph gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12175] "(lim-FAT-ik SIS-tem) The tissues and organs that produce, store, and carry white blood cells that fight infections and other diseases. This system includes the bone marrow, spleen, thymus, lymph nodes, and lymphatic vessels (a network of thin tubes that carry lymph and white blood cells).  Lymphatic vessels branch, like blood vessels, into all the tissues of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12176] "A type of white blood cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12177] "(mee-dee-a-STYE-num) The area between the lungs. The organs in this area include the heart and its large blood vessels, the trachea, the esophagus, the bronchi, and lymph nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12178] "A thin sheet or layer of pliable tissue, serving as a covering or envelope of a part, as the lining of a cavity, as a partition or septum, or to connect two structures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12179] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12180] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12181] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12182] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12183] "all of the muscles, the bones, and the cartilages of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12184] "The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12185] "A specialized structure that serves as an organ of the sense of smell as well as part of the respiratory system; the term includes both the external nose and the nasal cavity. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12186] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12187] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12188] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12189] "intraocular portion of the optic nerve formed by fibers converging from retina and appearing as a pink to white disk."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12190] "The nerve that carries messages from the retina to the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12191] "(or-o-FAIR-inks) The middle part of the throat that includes the soft palate, the base of the tongue, and the tonsils."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12192] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12193] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12194] "(pair-a-THIGH-roid) Four pea-sized glands found on the thyroid. The parathyroid hormone produced by these glands increases the calcium level in the blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12195] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12196] "The lower part of the abdomen, located between the hip bones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12197] "The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12198] "The lower part of the abdomen that contains the intestines (the last part of the digestive tract), the stomach, and the liver. It is bound by thin membranes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12199] "(PAIR-ih-toe-NEE-um) The tissue that lines the abdominal wall and covers most of the organs in the abdomen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12200] "Lymphoid tissue on the mucosa of the small intestine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12201] "The glandular or anterior lobe of the pituitary gland which secretes several hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12202] "The neural or post-neural lobe of the pituitary gland which stores and releases vasopressin, oxytocin, and neurophysins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12203] "large artery originating from the superior surface of right ventricle and carrying deoxygenated blood from heart to lung."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12204] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12205] "large vein carrying oxygenated blood from lungs to left atrium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12206] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12207] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12208] "(RES-pih-ra-tor-ee) The organs that are involved in breathing. These include the nose, throat, larynx, trachea, bronchi, and lungs.Also known as the respiratory tract."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12209] "A widely distributed collection of both free and fixed macrophages derived from bone marrow precursor cells by way of monocytes; their substantial phagocytic activity is mediated by immunoglobulin and the serum complement system. In both connective and lymphoid tissue, they may occur as free and fixed macrophages; in the sinusoids of the liver, as Kupffer cells; in the lung, as alveolar macrophages; and in the nervous system, as microglia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12210] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12211] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12212] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12213] "The white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm. (From Cline et al., Dictionary of Visual Science, 4th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12214] "(SKRO-tum) In males, the external sac that contains the testicles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12215] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12216] "(SEM-in-al VES-ih-kulz) Glands that help produce semen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12217] "Having to do with the skeleton (boney part of the body)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12218] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12219] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12220] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12221] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12222] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12223] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12224] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12225] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12226] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12227] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12228] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12229] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12230] "(TISH-oo) A group or layer of cells that are alike and that work together to perform a specific function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12231] "Small masses of lymphoid tissue on either side of the throat."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12232] "A porelike structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates to the canal of Schlemm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12233] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12234] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12235] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12236] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12237] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12238] "One of the bones that comprise the forearm. The largest aspect articulates with the humerus at the elbow joint and the smallest portion of the ulna articulates with the carpal bones in the wrist. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12239] "(GEN-ih-toe-YOO-rin-air-ee) The parts of the body that play a role in reproduction, getting rid of waste products in the form of urine, or both."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12240] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12241] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12242] "A coiled tube that carries the sperm out of the testes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12243] "is a blood vessel of macroscopic dimensions, the lumen of which is continuous with the atria of the heart, directly or indirectly through tributaries of the venae cavae, pulmonary veins and the hepatic and portal veins. Example(s): coronary sinus, posterior intercostal vein, renal vein, basal vein of right lung, inferior mesenteric vein."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12244] "A large vein that empties into the heart. It carries blood from the legs and feet and from organs in the abdomen and pelvis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12245] "The large vein that carries blood from the head, neck, arms, and chest to the heart."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12246] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12247] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12248] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12249] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12250] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12251] "Two small bands of muscle within the larynx. They close to prevent food from getting into the lungs, and they vibrate to produce the voice."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12252] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12253] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12254] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12255] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12256] "A centrally placed component of the ventricular system of the brain located in the diencephalon. Cerebrospinal fluid from the lateral ventricles flows into the third ventricle via the foramina of Monroe and exits the third ventricle via the aqueduct of Sylvius. The thalamus and hypothalamus border the lateral walls of the third ventricle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12257] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12258] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12259] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12261] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12262] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12263] "The rostral extensions of the ventricular system of the brain consisting of two cavities, one on each side of the brain within the central regions of each cerebral hemisphere.  Cerebrospinal fluid flows from the lateral ventricles into the centrally third ventricle via the foramen of Monroe."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12264] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12265] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12266] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12267] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12268] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12269] "A space enclosed by the pleura (thin tissue covering the lungs and lining the interior wall of the chest cavity). The pleural cavity is bound by thin membranes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12270] "In women, this system includes the ovaries, the fallopian tubes, the uterus (womb), the cervix, and the vagina (birth canal). The reproductive system in men includes the prostate, the testes, and the penis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12271] "Grafts used in the treatment of skin loss, usually caused by burn injuries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12272] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12273] "Relating to a neck, or cervix, in any sense."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12274] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12276] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12277] "A simple or stratified flat epithelium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12278] "(SKWAY-mus) Flat cells that look like fish scales under a microscope. These cells cover internal and external surfaces of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12279] "The part of the epidermis layer of the skin containing Langerhans cells, which are dendritic, MHC class II-expressing antigen presenting cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12280] "The organ of milk secretion; one of two hemispheric projections of variable size situated in the subcutaneous layer over the pectoralis major muscle on either side of the chest of the mature female; it is rudimentary in the male."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12281] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12282] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12283] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12284] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12285] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12286] "A bone of the carpus at the base of the first metacarpal, or thumb. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12287] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12288] "A bone in the distal row of the carpus; it articulates with the second metacarpal, trapezium, capitate, and scaphoid. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12289] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12290] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12291] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12292] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12293] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12294] "The main type of cell forming the lining of blood and lymph vessels and the inner layer of the endocardium. SYN endotheliocyte."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12295] "Cells that vary in shape depending on whether the tissue is being stretched.  The cells may be stretched without breaking apart.  They line hollow organs such as the bladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12296] "Epithelia of lung alveoli. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12297] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12298] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12299] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12300] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12301] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12302] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12303] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12304] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12305] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12306] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12307] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12308] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12309] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12310] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12311] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12312] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12313] "The lining of the ureters, bladder, and urethra."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12314] "The fibrous connective tissue that surrounds each kidney."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12315] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12316] "The area at the center of the kidney. Urine collects here and is funneled into the ureter, the tube that connects the kidney to the bladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12317] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12318] "The organs involved with detecting and processing auditory information, including the pinna, external auditory canal, ear drum, middle ear, and inner ear (including the cochlear organ)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12319] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12320] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12321] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12322] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12323] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12324] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12325] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12326] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12327] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12328] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12329] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12330] "The part of the conjunctiva, a thin transparent mucous membrane, that covers the posterior surface of the eyelids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12331] "The part of the conjunctiva, a thin transparent mucous membrane, that is loosely attached the orbital septum and covers the anterior surface of the sclera."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12332] "Lymph nodes located above the clavicle (collarbone)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12333] "Lymph nodes found in the armpit that drain the lymph channels from the breast."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12334] "The cavity in the vertebrate body enclosed by the ribs between the diaphragm and the neck and containing the lungs and heart."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12335] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12336] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12337] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12338] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12339] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12340] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12341] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12342] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12343] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12344] "A lymphoid cell of follicular center cell origin that has an irregularly shaped nucleus with clumped chromatin, absent nucleoli, and one or more clefts in the nuclear membrane."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12345] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12346] "Cells of, or derived from, a malignant tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12347] "Blast cells are in an immature (undifferentiated) stage in cellular development, occurring before the appearance of the definitive characteristics exhibited by fully differentiated cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12348] "An anatomical structure that consists of organs and organ subclasses responsible for certain body functions.  Representative examples are the gastrointestinal system, urinary system, and hematopoietic system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12349] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12350] "A type of white blood cell that contains granules with enzymes that can kill tumor cells or microbial cells. Also called natural killer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12351] "Cells of, or derived from, a tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12352] "Located in the upper part of the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12353] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12354] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12355] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12356] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12357] "Stratified squamous epithelium that covers the outer surface of the CORNEA. It is smooth and contains many free nerve endings."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12358] "is a subdivision of the peripheral nervous system (organ system subdivision), which consists of subdivisions of two or more nerves, which are interconnected with one another to form an network through which nerve fibers of the constituent nerves of the plexus become regrouped; together with other nerve plexuses and nerves, it constitutes the peripheral nervous system. Example(s): brachial plexus, cardiac plexus, inferior hypogastric plexus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12359] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12360] "Refers to the meninges, the tissue covering the brain and spinal cord."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12361] "A graft transferred from an animal of one species to one of another species."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12362] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12363] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12364] "Embryonic stem cells are pluripotent and can give rise to all of the different types of specialized cells in the body but are incapable of forming an entire organism under any known condition."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12365] "Non-encapsulated accumulations of lymphoid tissue in the alimentary tract that form a secretory immune system containing cells committed to IgA or IgE synthesis; It includes Peyer's patches and the lymphoid tissue which is present throughout the gastrointestinal mucosa. (partially adapted from CSP98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12366] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12367] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12368] "A person's white blood cells. Lymphocytes have a number of roles in the immune system, including the production of antibodies and other substances that fight infection and disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12369] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12370] "T cells that have been coated with monoclonal antibodies to enhance their ability to kill tumor cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12371] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12372] "(in-tra-THEE-kal) Describes the fluid-filled space between the thin layers of tissue that cover the brain and spinal cord.  Drugs can be injected into the fluid or a sample of the fluid can be removed for testing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12373] "Lymph nodes located above the collar bone and between the center of the body and a line drawn through the nipple to the shoulder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12374] "(NOO-ro-EN-do-krin) Having to do with the interactions between the nervous system and the endocrine system.  Neuroendocrine describes certain cells that release hormones into the blood in response to stimulation of the nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12375] "Immature cells found circulating in the bloodstream. New blood cells develop from peripheral stem cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12376] "The first lymph node to which cancer is likely to spread from the primary tumor. Cancer cells may appear first in the sentinel node before spreading to other lymph nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12377] "(dukt) A tube through which body fluids pass."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12378] "All the body cells except the reproductive (germ) cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12379] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12380] "A vague term that usually refers to the phagocytic cells (macrophages) of the spleen. (from On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12381] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12382] "Fluids and secretions related to the nervous system. The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. SYN systema nervosum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12383] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12384] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12385] "The components of the eye that are also part of the nervous system, including the retina and optic nerve."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12386] "All endocrine glands, considered as a coherent system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12387] "A cell originating from or isolated from an animal of class Mammalia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12388] "Cells found in human breast cancers or extracted from cancers as established cell lines"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12389] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12390] "Trachea -The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi. Bronchi-The larger air passages of the lungs arising from the terminal bifurcation of the trachea."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12391] "A tumor progenitor cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12392] "The epithelium that lines the intestinal tract."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12393] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12394] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12395] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12396] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12397] "New blood vessels formed by solid tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12398] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12399] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12400] "One of two hemispheric projections of variable size situated in the subcutaneous layer over the pectoralis major muscle on either side of the chest."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12401] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12402] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12403] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12404] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12405] "A term used to describe a condition that may (or is likely to) become cancer. Also called precancerous."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12406] "Cells that are able to develop into several different types of cells or tissues in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12407] "Totipotent stem cells, such as the product of fertilization of an ovum and its progeny, are stem cells that have total potency to form an entire mature organism, e.g., a human being, although only if placed in a woman's uterus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12408] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12409] "Arteries which have their origins within the intracranial cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12410] "Healthy skin, bone, or other tissue taken from one part of the body and used to replace diseased or injured tissue removed from another part of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12411] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12412] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12413] "One of the nodes that lie along the course of a lymphatic vessel between a primary melanoma site and a recognized node field. (from Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12414] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12415] "(al-VEE-o-lye) Tiny air sacs at the end of the bronchioles in the lungs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12416] "A small epidermoid structure of the conjunctiva of the eye that lies near the inner canthus.  It serves as a transition zone between cutaneous and mucous membrane components."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12417] "A hybrid cell with cytoplasm (or cytoplasmic components) of one cell inserted into another cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12418] "A thin fibrous membrane that covers the outer surface of the anteriors sclera and contains blood vessels which supply the sclera."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12419] "(LOB-yule) A small lobe or subdivision of a lobe."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12420] "An embryonic nerve cell capable of differentiating into a neuron."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12421] "Splenic pulp seen grossly as a reddish brown substance, due to its abundance of red blood cells, consisting of splenic sinuses and the tissue intervening between them (splenic cords)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12422] "The part of the spleen that consists of nodules and other lymphatic concentrations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12423] "A cell that develops in the thymus, seemingly from a stem cell of bone marrow and of fetal liver, and is the precursor of the thymus-derived lymphocyte (T lymphocyte) that effects cell-mediated (delayed type) sensitivity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12424] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12425] "The eighth cranial nerve composed of the acoustic nerve and the vestibular nerve.  The nerve travels from the inner ear, enters the cranial cavity through the internal auditory foramen and joins the brainstem.  The auditory nerve conveys impulses from the cochlea of the inner ear to the auditory nuclei of the brainstem.  The vestibular nerve carries information from the labyrinths of the inner ear to the vestibular nuclei of the brainstem."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12426] "is a three-dimensional anatomical spatial entity, which is generated by morphogenetic or other physiologic processes that generate anatomical structures; it is enclosed by anatomical structures and contains one or more anatomical structures or body substances. Example(s): celom, thoracic cavity, lesser sac of peritoneum, cavity of right atrium, lumen of blood vessel, mediastinum, anterior compartment of forearm, intervertebral foramen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12427] "excludes sacrum and coccyx C41.4"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12428] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12429] "Large single cells, either cylindrical or prismatic in shape, that form the basic unit of muscle tissue. They consist of a soft contractile substance enclosed in a tubular sheath."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12430] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12431] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12432] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12433] "The innermost layer of the heart, comprised of endothelial cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12434] "The fibroserous sac surrounding the heart and the roots of the great vessels."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12435] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12436] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12437] "RAEB: Cytolytic lymphocytes with the unique capacity of killing natural killer (NK)-resistant fresh tumor cells. They are interleukin-2-activated NK cells that have no MHC (major histocompatibility complex) restriction or need for antigen stimulation. LAK cells are used for adoptive immunotherapy in cancer patients. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12438] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12439] "Small, flat, granular glands embedded in the submucous areolar tissue of the duodenum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12440] "The hepatopancreatic ampulla. A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12441] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12442] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12443] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12444] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12445] "The primary female sex organs or genitals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12446] "the primary male sex organs or genitals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12447] "A part of the body that performs a specific function.  For example, the heart is an organ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12448] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12449] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12450] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12451] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12452] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12453] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12454] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12455] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12456] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12457] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12458] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12459] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12460] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12461] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12462] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12463] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12464] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12465] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12466] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12467] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12468] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12469] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12470] "The entire physical structure of an organism.  It is composed of anatomic systems, regions, cavities, and spaces."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12471] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12472] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12473] "Joint; the point of connection between two bones or elements of a skeleton, especially if the articulation allows motion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12474] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12475] "Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12476] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12477] "The functional units of the kidney, consisting of the glomerulus and the attached tubule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12478] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12479] "Skeletal muscles are striated muscles that are under voluntary control of the organism.  They are connected at either or both ends to a bone and are utilized for locomotion and other movements. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12480] "Tissue in which new blood cells are formed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12481] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12482] "Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components from interstitium to lumen; this function has been most intensively studied in the blood capillaries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12483] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12484] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12485] "Muscle; one of the contractile organs of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12486] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12487] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12488] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12489] "Clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons. Sensory ganglia may also have intrinsic interneurons and non-neuronal supporting cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12490] "The cells of the body which stain with chromium salts. They occur along the sympathetic nerves, in the adrenal gland, and in various other organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12491] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12492] "The region that connects the head to the rest of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12493] "encompasses the mouth, esophagus, stomach, intestines, biliary tract, pancreas, liver, and associated hormones and secretions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12494] "The muscle fibres around the opening of the common bile duct (ductus choledochus) into the duodenum at the papilla of Vater."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12495] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12496] "Gray matter located in the dorsomedial part of the medulla oblongata associated with the solitary tract. The solitary nucleus receives inputs from most organ systems including the terminations of the facial, glossopharyngeal, and vagus nerves. It is a major coordinator of autonomic nervous system regulation of cardiovascular, respiratory, gustatory, gastrointestinal, and chemoreceptive aspects of homeostasis. The solitary nucleus is also notable for the large number of neurotransmitters which are found therein."                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12497] "The TARSUS, METATARSUS, and phalanges. The tarsus consists of seven bones: calcaneum, astragalus, cuboid, navicular, internal, middle, and external cuneiform bones. The five METATARSAL BONES are numbered one through five, running medial to lateral. There are 14 phalanges in each foot, the great toe has two while the other toes have three each."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12498] "The mouth, teeth, jaws, pharynx, and related structures as they relate to mastication, deglutition, and speech."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12499] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12500] "The anterior portion of the head that includes the skin, muscles, and structures of the forehead, eyes, nose, mouth, cheeks, and jaw."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12501] "The teeth collectively in the dental arch. Dentition ordinarily refers to the natural teeth in position in their alveoli. Dentition referring to the deciduous teeth is DENTITION, PRIMARY; to the permanent teeth, DENTITION, PERMANENT. (From Jablonski, Dictionary of Dentistry, 1992)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12502] "Muscles of facial expression or mimetic muscles that include the numerous muscles supplied by the facial nerve that are attached to and move the skin of the face. (From Stedman, 25th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12503] "Muscles arising in the zygomatic arch that close the jaw. Their nerve supply is masseteric from the mandibular division of the trigeminal nerve. (From Stedman, 25th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12504] "The muscles of the pharynx are the inferior, middle and superior constrictors, salpingopharyngeus, and stylopharyngeus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12505] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12506] "any of the cells lining an acinus; acinus is a general term used to designate a small saclike dilatation, particularly one found in various glands."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12507] "A thin membrane that lines the ventricles of the brain and the central canal of the SPINAL CORD."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12508] "Neural tracts connecting one part of the nervous system with another."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12509] "Nerve structures through which impulses are conducted from a peripheral part toward a nerve center."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12510] "Nerve structures through which impulses are conducted from a nerve center toward a peripheral site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12511] "White matter pathway, flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the cerebral cortex and the brainstem. It consists of three distinct parts: an anterior limb, posterior limb, and genu."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12512] "A complex group of fibers arising from the basal olfactory regions, the periamygdaloid region, and the septal nuclei, and passing to the lateral hypothalamus. Some fibers continue into the tegmentum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12513] "A pathway of fibers originating in the lateral part of the entorhinal area, perforating the subiculum of the hippocampus, and running into the stratum moleculare of the hippocampus, where these fibers synapse with others that go to the dentate gyrus. It is also called the perforating fasciculus. (Dorland, 28th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12515] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12516] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12517] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12518] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12519] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12522] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12523] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12524] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12526] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12527] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12529] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12531] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12534] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12535] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12536] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12537] "An abnormally large red blood cell occurring mainly in anemias (as pernicious anemia), also called megalocyte.  Lack of vitamin B12 and folic acid could also cause macrocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12538] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12539] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12540] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12541] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12542] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12543] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12544] "A medium-sized round lymphocyte of B or T-cell lineage with prominent nucleoli.  It is an intermediate cell between the lymphoblast and the small, mature lymphocyte."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12545] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12546] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12547] "The precursor of a megakaryocyte."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12548] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12549] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12550] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12551] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12552] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12553] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12554] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12555] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12556] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12557] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12558] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12559] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12560] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12561] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12562] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12563] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12564] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12565] "It is the epithelium cell that produces mucin gel adherent to the mucosal surface. Mucus-secreting cells are widely distributed through the body. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12566] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12568] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12569] "The intercalated cell is an epithelial cell of the renal collecting tubule that is specialized for H+ and HCO3 transport. These cells exist in two types, [alpha] and [beta]. The [alpha] cell secretes H+ into the lumen by an apical H+ ATPase and a basolateral Cl:HCO3. The [beta] cell secretes HCO3- into the lumen by an apical Cl:HCO3 and a basolateral H+ ATPase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12570] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12571] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12572] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12573] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12574] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12575] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12576] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12577] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12578] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12579] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12580] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12581] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12582] "Cells found within the glomerular lobules of mammalian kidney, where they serve as structural supports, may regulate blood flow, are phagocytic and may act as accessory cells, presenting antigen in immune responses. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12583] "The intercalated cell is an epithelial cell of the renal collecting tubule that is specialized for H+ and HCO3 transport. These cells exist in two types, [alpha] and [beta]. The [alpha] cell secretes H+ into the lumen by an apical H+ ATPase and a basolateral Cl:HCO3. The [beta] cell secretes HCO3- into the lumen by an apical Cl:HCO3 and a basolateral H+ ATPase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12584] "Any of a group of cells that are situated in the wall of each afferent arteriole of a kidney glomerulus near its point of entry adjacent to a macula densa and that produce and secrete renin.(Online Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12585] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12586] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12587] "The moist tissue that lines some organs and body cavities (such as the nose, mouth, lungs) and makes mucus (a thick, slippery fluid)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12588] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12589] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12590] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12591] "A small spherical body composed of keratinized squamous epithelial cells arranged in a concentric pattern in the medullary portion of the thymus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12592] "One of numerous oval bodies found in the papillae of the skin, especially those of the fingers and toes; they consist of a connective tissue capsule in which the axon fibrils terminate around and between a pile of wedge-shaped epithelioid cells. SYN corpusculum tactus, oval corpuscle, touch corpuscle. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12593] "A specialized bulblike nerve ending located in the subcutaneous tissue of the skin; occurs abundantly in the skin of palms and soles and joints and genitals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12594] "A specialized tactile sensory nerve ending in the epidermis, characterized by a terminal cuplike expansion of an intraepidermal axon in contact with the base of a single modified keratinocyte. SYN meniscus tactus, Merkel's corpuscle, Merkel's tactile cell, Merkel's tactile disk, tactile disk. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12595] "Free nerve endings are widely distributed throughout the body, and are found as branches of unmyelinated, or lightly myelinated fibres grouped in bundles beneath the epithelium. As they penetrate the epithelium, they lose their myelin, and branch among the epithelial cells. Branches of one nerve may cover a wide area and overlap the territories of other nerves. The free nerve endings detect pain, touch, pressure and temperature, and are associated with C fibres."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12596] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12597] "A free nerve ending that is a receptor for painful stimuli. (Kanner)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12598] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12599] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12600] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12601] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12602] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12603] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12604] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12605] "The outer membrane that surrounds a bone. It contains connective tissue, capillaries, nerves, and a number of types of cell, including osteoclasts. The periosteum plays an important role in bone repair and growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12607] "A-DNA is a shorter and wider helix than B-DNA. Most RNA and RNA-DNA duplex are in this form. While deep, narrow major groove is not easily accessible to proteins but wide, shallow minor groove is accessible to proteins but with lower information content than major groove. A-DNA is the favored conformation at low water concentrations. Base pairs are tilted to helix axis and displaced from axis and sugar pucker is C3'-endo (in RNA 2'-OH inhibits C2'-endo conformation). When examined from the top of the helix, there is a large hole in the middle, the sugar phosphate backbone is at the edge of the helix, and the bases are displaced towards the edge."                                                                                                                                                                                                                                                                                                                      
[12608] "The arrangement of amino acids in a protein.  Proteins can be made from 20 different kinds of amino acids, and the structure and function of each type of protein are determined by the kinds of amino acids used to make it and how they are arranged."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12609] "The fluid within the amniotic cavity which surrounds and protects the developing embryo.  It is initially produced by the amnion and then later by the lungs and kidneys.  The amount at term normally varies from 500 to 2000 ml."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12610] "(EP-i-tope) A part of a molecule that an antibody will recognize and bind to."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12611] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12612] "Ubiquitous supportive tissue adjacent to epithelium and around smooth and striated muscle cells. This tissue contains intrinsic macromolecular components such as collagen, laminin, and sulfated proteoglycans. As seen by light microscopy one of its subdivisions is the basal (basement) lamina."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12613] "A fluid made by the liver and stored in the gallbladder. Bile is excreted into the small intestine, where it helps digest fat."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12614] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12615] "A network of blood vessels with closely spaced cells that makes it difficult for potentially toxic substances (such as anticancer drugs) to penetrate the blood vessel walls and enter the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12616] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12617] "Within most types of eukaryotic CELL NUCLEUS, a distinct region, not delimited by a membrane, in which some species of rRNA (RNA, RIBOSOMAL) are synthesized and assembled into ribonucleoprotein subunits of ribosomes. In the nucleolus rRNA is transcribed from a nucleolar organizer, i.e., a group of tandemly repeated chromosomal genes which encode rRNA and which are transcribed by RNA polymerase I."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12618] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12619] "The nonstaining primary constriction of a chromosome which is the point of attachment of the spindle fiber; provides the mechanism of chromosome movement during cell division; the centromere divides the chromosome into two arms, and its position is constant for a specific chromosome: near one end (acrocentric), near the center (metacentric), or between (submetacentric)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12620] "Photosynthetic organelle containing chlorophyll, the photosynthetic pigment, in cells of leaves and young stems of higher plants. Lens-shaped and rather variable in size but approximately 5 m long. Surrounded by a double membrane and contains circular DNA (though not enough to code for all proteins in the chloroplast). Like the mitochondrion, it is semi-autonomous. It resembles a cyanobacterium from which, on the endosymbiont hypothesis, it might be derived. Chlorophyll is associated with the membrane of vesicles (thylakoids) that are stacked to form grana."                                                                                                                                                                                                                                                                                                                                                                                                                
[12621] "Either of the two longitudinally adjacent threads formed when a eukaryotic chromosome replicates prior to mitosis. The chromatids are held together at the centromere. Sister chromatids are derived from the same chromosome. (Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed). (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12622] "The genetic material of the nucleus, consisting of deoxyribonucleoprotein, which occurs in two forms during the phase between mitotic divisions: 1) as heterochromatin, seen as condensed, readily stainable clumps; 2) as euchromatin, dispersed lightly staining or nonstaining material. During mitotic division the chromatin condenses into chromosomes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12623] "(KRO-mo-some) Part of a cell that contains genetic information. Except for sperm and eggs, all human cells contain 46 chromosomes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12624] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12625] "One of the three pairs in the first group (or group A) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12626] "One of the seven pairs in the third group (or group C) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12627] "One of the seven pairs in the third group (or group C) of human chromosomes according to the current classification for humans. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12628] "One of the seven pairs in the third group (or group C) of human chromosomes according to the current classification for humans. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12629] "One of three pairs in the fourth group (or group D) of human chromosomes according to the current classification for humans. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12630] "One of three pairs in the fourth group (or group D) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12631] "One of the three pairs in the fourth group (or group D) of human chromosomes according to the current classification for humans. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12632] "One of the three pairs in the fifth group (or group E) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12633] "One of the three pairs in the fifth group (or group E) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12634] "One of the three pairs in the fifth group (or group E) of human chromosomes according to the current classification for humans. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12635] "One of the two pairs in the sixth group (or group F) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12636] "One of the three pairs in the first group (or group A) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12637] "One of the two pairs in the sixth group (or group F) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12638] "One of the two pairs in the seventh group (or group G) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12639] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12640] "One of the three pairs in the first group (or group A) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12641] "One of the two pairs in the second group (or group B) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12642] "One of the two pairs in the second group (or group B) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12643] "One of the seven pairs in the third group (or group C) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12644] "One of the seven pairs in the third group (or group C) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12645] "One of the seven pairs in the third group (or group C) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12646] "One of the seven pairs in the third group (or group C) of human chromosomes according to the current classification for humans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12647] "That portion of the cell contained within the plasma membrane but excluding the nucleus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12648] "The protein scaffolding (the network of filaments microfilaments, microtubules, intermediate filaments, and their associated proteins) give shape, structure, and organization to the cytoplasm and a cell its shape."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12649] "Highly repetitive DNA sequences found in heterochromatin, mainly near centromeres.  They are composed of very short simple sequences repeated in tandem many times to form large blocks of sequence.  Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves.  The degree of repetition is on the order of 1000 to 10 million at each locus.  Loci are few, usually one or two per chromosome.  They are called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct base composition."                                                                                                                                                                                                                                                                                                                                                
[12650] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12651] "The endoplasmic reticulum is a network of tubular membranes within the cytoplasm of the cell, occurring either with a smooth surface (smooth endoplasmic reticulum) or studded with ribosomes (rough endoplasmic reticulum), involved in the transport of materials. (Infoplease Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12652] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12653] "A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12654] "Material, such as purulent and nonpurulent fluid, cells, or cellular debris, which has escaped from blood vessels and has been deposited in tissues or on tissue surfaces, usually as a result of inflammation.  An exudate, in contrast to a transudate, is characterized by a relatively high protein content."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12655] "feces. The matter discharged from the bowel during defecation, consisting of the undigested residue of the food, epithelium, the intestinal mucus, bacteria, and waste material from the food. SYN stercus. (STED98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12656] "(FEET-us) The developing offspring from 7 to 8 weeks after conception until birth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12657] "Liquids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12658] "A stack of flattened vesicles located between the nucleus and the secretory pole or surface of a cell. Functions in posttranslational processing and sorting of proteins, receiving them from the rough endoplasmic reticulum and directing them to secretory vesicles, lysosomes, or the cell membrane. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or golgi apparatus and fuse with the golgi, lysosomes or cell membrane."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12659] "Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12660] "regions of the genome that are permanently in a highly condensed condition and are not genetically expressed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12661] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12662] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12663] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12664] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12665] "Part of an immunoglobulin antibody that binds a specific antigen and consists of both a light chain and part of a heavy chain.  By comparison, natural antibodies consist of two heavy and two light chains.  An FAB (fragment antibody) offers the advantages of smaller size and lower cross-reactivity compared to the complete antibody. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12666] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12667] "A class of tough protein filaments (including keratin filaments, neurofilaments, desmin, and vimentin) that measure 8-10 nm in thickness and comprise part of the cytoskeleton of the cytoplasm of most eukaryotic cells; so named because they are intermediate in thickness between actin filaments and microtubules."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12668] "Non-coding, intervening sequences of DNA that are transcribed, but are removed from within the primary gene transcript and rapidly degraded during maturation of messenger RNA. Most genes in the nuclei of eukaryotes contain introns, as do mitochondrial and chloroplast genes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12669] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12670] "Identical DNA sequences found at either end of retrovirus proviral DNA, formed by reverse transcription of viral RNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12671] "(lim-FAT-ik) The clear fluid that travels through the lymphatic system and carries cells that help fight infections and other diseases. Also called lymph."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12672] "A class of morphologically heterogeneous cytoplasmic membrane-bound vesicle in animal and plant tissues characterized by their content of a wide variety of glycoprotein hydrolytic enzymes active at an acid pH and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture serves to digest exogenous material, such as bacteria, as well as effete organelles of the cells and is supposed to be under metabolic (hormonal) control."                                                                                                                                                                                                          
[12673] "Subcellular respiratory organelles containing catalase and hydrogen peroxide-producing flavin oxidases among its enzymatic constituents, which carry out an essentially oxidative type of metabolism"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12674] "The finest filamentous element of the cytoskeleton, having a diameter of about 5 nm and consisting primarily of actin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12675] "A cylindrical cytoplasmic element, 20 to 27 nm in diameter and of variable length, that occurs widely in the cytoskeleton of plant and animal cells; microtubules increase in number during mitosis and meiosis, where they may be related to movement of the chromosomes or chromatids on the nuclear spindle during nuclear division."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12676] "The fluid secretion of the mammary gland forming the natural food of young mammals. (Dorland, 28th ed) It often refers to cow's milk used as a food by humans. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12677] "Parts of a cell where aerobic production (also called cell respiration) takes place."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12678] "A thick, slippery fluid produced by the membranes that line certain organs of the body, including the nose, mouth, throat, and vagina."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12679] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12680] "fatty, axon-enwrapping sheath that serves to speed up neural conduction, formed by concentric layers of Schwann's cell (peripheral) or oligodendrocyte (CNS) membranes; loss or damage leads to severe loss of neural function, as in multiple sclerosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12681] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12682] "intermediate filaments of neurons which add rigidity, tensile strength, and possibly intracellular transport guidance to axons and dendrites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12683] "A fibrogranular network of residual structural elements within which are immersed both chromatin and ribonucleoproteins. It appears to extend throughout the nuclear interior from the nucleolus to the nuclear pore complexes along the nuclear periphery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12684] "The nuclear envelope is the double-layer membrane structure enclosing the nucleus in eukaryotic cells. It separates the DNA of the cell from the cytosol. For exchange of material, for example, proteins and mRNA, it is punctured with numerous nuclear pores. (from Wikipedia and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12685] "An octagonal opening, about 70 nm across, where the inner and outer membranes of the nuclear envelope are continuous."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12686] "Nucleolar organizer regions (NORs), which are loops of DNA containing ribosomal RNA genes, have been shown to correlate with cell proliferation and malignant transformation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12687] "The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. This core is composed of the histones H2A, H2B, H3, and H4."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12688] "A structurally discrete component of a cell. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12689] "Fluids made by the pancreas. Pancreatic juices contain proteins called enzymes that aid in digestion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12690] "An abnormality of chromosome 22 in which part of chromosome 9 is transferred to it.  Bone marrow cells that contain the Philadelphia chromosome are often found in chronic myelogenous leukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12691] "The organ that nourishes the developing fetus in the uterus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12692] "Pulmonary surfactant lines the lung epithelium and lowers surface tension to prevent collapse at end-expiration. Deficiency of pulmonary surfactant results in respiratory distress syndrome (RDS) in premature infants. Lung surfactant is synthesized in alveolar type II cells, stored in lamellar bodies and secreted via exocytosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12693] "A granule of ribonucleoprotein, 120 to 150 A in diameter, is the site of protein synthesis from aminoacyl-tRNAs as directed by mRNAs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12694] "(suh-LIE-vuh) The watery fluid made by mucous glands in the mouth. It moistens food to aid in digestion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12695] "(SEE-bum) An oily substance produced by certain glands in the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12696] "Fluid from the prostate and other sex glands that helps transport sperm out of the man's body during orgasm.  Seminal fluid contains sugar as an energy source for sperm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12697] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12698] "The liquid secreted by the sweat glands, having a salty taste and a pH that varies from 4.5 to 7.5. Sweat produced by the eccrine sweat glands is clear with a faint characteristic odor, and contains water, sodium chloride, and traces of albumin, urea, and other compounds. Its composition varies with many factors, e.g., fluid intake, external temperature and humidity, and some hormonal activity. Sweat produced by the larger, deeper, apocrine sweat glands of the axillae contains, in addition, organic material which on bacterial decomposition produces an offensive odor."                                                                                                                                                                                                                                                                                                                                                                                                      
[12699] "A connection between excitable cells, by which an excitation is conveyed from one to the other. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12700] "Used with tissues and cells (including neoplasms) and microorganisms for microanatomic structures, generally below the size visible by light microscopy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12701] "(YOO-rin) Fluid containing water and waste products. Urine is made by the kidneys, stored in the bladder, and leaves the body through the urethra."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12702] "membrane-enclosed spherules that serve as subcellular packaging for nutrients, waste, or secretory compounds, or as vehicles to and from the cell membrane; do not use for artificial lipid vesicles (see MEMBRANE MODEL)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12703] "The female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in man and other male-heterogametic species. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12704] "The male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in man and in some other male-heterogametic species in which the homologue of the X chromosome has been retained."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12705] "\"zigzag\" left-handed conformer of DNA; naturally occurring Z DNA is sensitive to a different set of enzymes and binding proteins than \"normal\" B DNA, and is thought to play an important role in genetic regulation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12706] "A consensus tripeptide that is recognized by and for binding to proteins of the integrin family, including many cell adhesion molecules. The one-letter codes for arginine - glycine - aspartic acid."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12707] "Euchromatin. The parts of chromosomes that, during interphase, are uncoiled dispersed threads and not stained by ordinary dyes; metabolically active, in contrast to the inert heterochromatin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12708] "Kringles are autonomous structural domains, found throughout the blood clotting and fibrinolytic proteins. Kringle domains are believed to play a role in binding mediators (e.g., membranes, other proteins or phospholipids), and in the regulation of proteolytic activity. Kringle domains are characterised by a triple loop, 3-disulphide bridge structure, whose conformation is defined by a number of hydrogen bonds and small pieces of anti-parallel beta-sheet. They are found in a varying number of copies, in some serine proteases and plasma proteins. (pfam.wustl.edu/cgi-bin/getdesc?name=kringle)"                                                                                                                                                                                                                                                                                                                                                                              
[12709] "Domains in DNA-binding proteins that contain amino acid sequences that show periodic arrays of leucine residues. These residues exist in an alpha-helical conformation, with the leucine side chains extending from one alpha helix interdigitating with those displayed from a similar alpha helix of a second polypeptide, facilitating dimerization."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12710] "A reading frame in a sequence of nucleotides in DNA that contains no termination codons and so can potentially translate as a polypeptide chain. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12711] "A conserved A-T rich sequence which is contained in promoters of genes transcribed by RNA polymerase II. The segment is seven base pairs long and the nucleotides most commonly found are TATAAAA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12712] "One of three structural motifs observed in DNA binding domains of zinc proteins. Domains in DNA- and RNA-binding proteins that contain amino acids which are folded into a single structural unit around a zinc atom that links two cysteines and two histidines. Each finger is postulated to recognize a specific sequence of about five nucleotide pairs. Originally identified in the TFIIIA transcription factor, it is also known as the C2H2 zinc finger."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12713] "The terminal end of a chromosome arm which has a specialized structure and which is involved in chromosomal replication and stability. Its length is believed to be a few hundred base pairs. Telomeres undergo dramatic changes during the progression of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12714] "A 50-150bp DNA sequence that increases the rate of transcription of coding sequences. It may be located at various distances and in either orientation upstream from, downstream from or within a structural gene.  When bound by a specific transcription factor it increases the levels of expression of the gene, but is not sufficient alone to cause expression. Distinguished from a promoter, that is alone sufficient to cause expression of the gene when bound."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12715] "A DNA sequence at which RNA polymerase binds and initiates transcription."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12716] "Nucleotide sequences present in multiple copies in the genome. There are several types of repeated sequences. Interspersed (or dispersed) DNA repeats ( INTERSPERSED REPETITIVE SEQUENCES) are copies of transposable elements interspersed throughout the genome.  Flanking (or terminal) repeats ( TERMINAL REPEAT SEQUENCES) are sequences that are repeated on both ends of a sequence, for example, the long terminal repeats (LTRs) on retroviruses. Direct terminal repeats are in the same direction and inverted terminal repeats are opposite to each other in direction. Tandem repeats ( TANDEM REPEAT SEQUENCES) are repeated copies which lie adjacent to each other. These can also be direct or inverted. The ribosomal RNA and transfer RNA genes belong to the class of middle repetitive DNA. The highly repetitive class sequences have often been refered to as \"junk DNA\" because they are mostly non-coding sequence."                                                     
[12717] "The sequence of nucleotide residues along a DNA chain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12718] "Blood from the placenta (afterbirth) that contains high concentrations of stem cells needed to produce new blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12719] "Embryonic tissue of mesodermal origin.  Develops into connective tissue, blood vessels, and lymphatic tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12720] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12721] "The amino acids and their 3-D arrangement in constituting a protein. The four levels of protein structuring in a water environment are primary (amino acid sequence), secondary (alpha helices and beta sheets), tertiary (formation of globular domains), and quaternary (interchain interactions)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12722] "Relating to the lungs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12723] "(lair-IN-jee-al) Having to do with the larynx."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12724] "Having to do with the heart."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12725] "(GAS-trik) Having to do with the stomach."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12726] "Refers to the liver."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12727] "Having to do with the vagina (the birth canal)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12728] "(sis-TEM-ik) Affecting the entire body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12729] "Relating to or containing blood vessels."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12730] "Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of connexins, the family of proteins which form the junctions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12731] "In transcription regulators of cell cycle control, cell determination, and cell differentiation, the conserved HLH (Helix-Loop-Helix) Domain of 40-50 amino acids forms amphipathic helixes between a variable loop. HLHs typically mediate homo- or heterodimerization through interactions with self or other motifs to activate or inactivate trans-activating function. The N-helix often contains DNA-interacting basic residues; the C-helix typically contains characteristically spaced hydrophobic residues. An adjacent basic region of 15 amino acids in most HLH proteins binds to DNA. Basic (b)HLH proteins bind variants of the 'CANNTG' E-box. Proteins lacking the basic domain act as inhibitors, failing to bind DNA. bHLH proteins exhibit specific dimerization partner combinations. In calcium-binding proteins, certain invariant hydrophilic loop residues in the HLH motif bind calcium. (NCI)"                                                                           
[12732] "Proteolytic complexes, proteolytic core of the proteasome system, that degrade cytosolic and nuclear proteins are implicated in ATP dependent ubiquitin protein complex degradation and in antigen processing in antigen presenting cells. The 20S proteasome (700 kD), essential in ATP ubiquitin degradation pathway, has 13-15 subunits each of which has three or four different peptidase activities. The 20S proteasome interacts with additional subunits, PA700 and PA28, to form an ATP-dependent multicatalytic proteinase complex (MPC) involved in the degradation of ubiquitinated cellular proteins and certain non-ubiquitinated proteins. 26S proteasomes may be formed in an ATP dependent fashion from a 20S proteasome and additional components, CF1 (660 kD), CF2 (250 kD) and CF3 (600 kD)."                                                                                                                                                                                  
[12733] "(ep-ih-THEE-lee-ul) Refers to the cells that line the internal and external surfaces of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12734] "(kyoo-TAY-nee-us) Having to do with the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12735] "(FOL-i-kul) A sac or pouch-like cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12736] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12737] "An organ that makes one or more substances, such as hormones, digestive juices, sweat, tears, saliva, or milk. Endocrine glands release the substances directly into the bloodstream. Exocrine glands release the substances into a duct or opening to the inside or outside of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12738] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12739] "Fluids and secretions within the passage leading from the mouth to the anus through the pharynx, esophagus, stomach, and intestine which cause digestion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12740] "Having to do with the endometrium (the layer of tissue that lines the uterus)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12741] "A clear, avascular, gelatinous body that occupies the posterior chamber of the eye.  It is bounded by the retina except anteriorly where it lies adjacent to the lens and iris."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12742] "Pertaining to or related to the formation of blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12743] "The clear liquid part of the blood that remains after blood cells and clotting proteins have been removed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12744] "The plane of the spindle approximately equidistant from the two poles along which the chromosomes are lined up during mitosis or meiosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12745] "Half desmosomes that occur on the basal surface of the stratum basalis of stratified squamous epithelium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12746] "A small pocket, vesicle, cave, or recess communicating with the outside of a cell and extending inward, indenting the cytoplasm and the cell membrane. Such caveolae may be pinched off to form free vesicles within the cytoplasm. They are considered to be sites of uptake of materials into the cell, expulsion of materials from the cell, or sites of addition or removal of cell (unit) membrane to or from the cell surface. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12747] "Membrane organelle of eukaryotes that forms sheets and tubules. Contains the receptor for the signal receptor particle and binds ribosomes engaged in translating mRNA for secreted proteins and the majority of transmembrane proteins. Also a site of membrane lipid synthesis. The membrane is very similar to the nuclear outer membrane. The lumen contains a number of proteins that possess the C terminal signal KDEL. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12748] "The mitochondrial outer membrane contains the multi-subunit machinery responsible for the specific recognition and translocation of precursor proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12749] "The inner mitochondrial membrane encloses a fluid-filled matrix and is elaborately folded with shelf-like cristae projecting into the matrix. The components of electron transport chain are integral part of the inner membrane."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12750] "Affecting both the right and left sides of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12751] "Found near the apical surface of cells in simple epithelia. Forms a sealing \"gasket\" around the cell by the fusion of adjacent cell membranes which encircle the apical cell surface like a belt or fence. Prevents fluid moving through the intercellular gap and the lateral diffusion of intrinsic membrane proteins between apical and basolateral domains of the plasma membrane as well as occludes the movement of solute molecules between cells. Various proteins components of this junction have been identified, but how they are linked to form the ultrastructure of the junction is not known."                                                                                                                                                                                                                                                                                                                                                                                    
[12752] "Minisatellite repeats.  Tandem arrays of moderately repetitive (5-50 repeats) short (10-60 bases) DNA sequences found dispersed throughout the genome and clustered near telomeres.  Their degree of repetition is two to several hundred at each locus.  Loci number in the thousands but each locus shows a distinctive repeat unit.  Minisatellite repeats are often called variable number of tandem repeats."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12753] "A DNA sequence necessary and sufficient for initiation of DNA replication."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12754] "Ubiquitinated proteins are degraded by a 26S ATP-dependent protease complex, composed of a 20S catalytic proteasome and two 19S PA700 regulatory modules.  The multi-subunit PA700 complex binds two sites of the 20S proteasome and is composed of at least six related ATPases and approximately fifteen non-ATPase polypeptides.  Each of the ATPases, PSMC1-6, contains an AAA (ATPases associated with diverse cellular activities) domain.  A protein complex containing p42 and p50 enhances PA700 activation of the proteasome."                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12755] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12756] "A variety of simple di- (DINUCLEOTIDE REPEATS), tri- (TRINUCLEOTIDE REPEATS), tetra-, and pentanucleotide tandem repeats that are dispersed in the euchromatic arms of most chromosomes. The dinucleotide repeat of guanine and thymine, (GT)n, is the most common of these dispersed repeats."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12757] "A region of protein sequence similarity among members of the SRC family of cytoplasmic tyrosine kinases, and other proteins. The SH2 domain usually mediates binding to phosphotyrosine and neighboring residues of target proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12758] "A region of protein sequence similarity among members of the SRC family of cytoplasmic tyrosine kinases, and other proteins. The SH3 domain is a protein-binding domain that interacts with cytoskeletal proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12759] "The first DNA-binding protein motif to be recognized. Originally identified in bacterial proteins and found in many DNA-binding proteins from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the \"turn.\" The two helices are held at a fixed angle, primarily through interactions between the two helices."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12760] "Within the variable domain of an antibody molecule are three regions called hypervariable regions, areas of high sequence diversity.  These regions form the surfaces that are resposible for antigen binding interactions.  Also known as complimentarity determining region or hypervariable loop."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12761] "A region of relative flexibility between the variable and constant regions of an antibody molecule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12762] "On the surface of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12763] "(STO-ma) A surgically created opening from an area inside the body to the outside."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12764] "(in-tra-VEE-nus) IV. Within a blood vessel."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12765] "(AS-pi-rit) Fluid withdrawn from a lump, often a cyst, or a nipple."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12766] "The group of organs and glands involved with having a child. In women, these are the uterus (womb), the fallopian tubes, the ovaries, and the vagina (birth canal). The reproductive system in men includes the testes, the prostate, and the penis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12767] "(MYE-eh-loyd) Pertaining to, derived from, or manifesting certain features of the bone marrow. In some cases also pertains to certain types of non-lymphocyte white blood cells found in the bone marrow, including granulocyte, monocyte, and platelet lineages. Also called myelogenous."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12768] "(lim-fo-SIT-ik) Referring to lymphocytes, a type of white blood cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12769] "(AK-sil-air-ee) Pertaining to the armpit area, including the lymph nodes that are located there."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12770] "(IN-tra-per-ih-toe-NEE-al) IP.  Within the peritoneal cavity (the area that contains the abdominal organs)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12771] "Beneath the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12772] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12773] "Under the microscope chromosomes appear as thin, thread-like structures. They all have a short arm and long arm separated by a primary constriction called the centromere. The short arm is designated as p and the long arm as q.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12774] "(PLAS-ma) The clear, yellowish, fluid part of the blood that carries the blood cells. The proteins that form blood clots are in plasma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12775] "(GAS-tro-in-TES-tih-nul) GI.  Refers to the stomach and intestines."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12776] "(thor-ASS-ik) Having to do with the chest."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12777] "Pertaining to the nucleus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12778] "Having to do with the heart and lungs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12779] "(ko-lo-REK-tul) Having to do with the colon or the rectum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12780] "Organ systems involved in self-stimulation through cellular production of a factor and a specific receptor for it."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12781] "The spindle pole body (SPB) is the microtubule organizing center (MTOC) in the yeast Saccharomyces that plays a pivotal role in such diverse processes as mitosis, budding, and mating. (from Cell. 1997;89:1077-86)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12782] "Specialized depressions on the cell surface involved in receptor-mediated endocytosis; the visible proteinaceous layer on the cytosolic side of the depression provides the coated appearance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12783] "The DNA-binding homeo domain was originally identified in transcription factor proteins encoded by homeobox genes (homeotic genes).  The homeo domain is structurally similar to the helix-turn-helix DNA-binding domain of CRO and Lambda repressor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12784] "A class of intermediate filaments that form a network within epithelial cells and anchor to desmosomes, thus imparting tensile strength to the tissue"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12785] "A right-handed spiral conformation; the a-helix has a pitch of 5.4 A and has 3.6 amino acid residues per turn; every main chain C=O and N-H group is hydrogen-bonded to a peptide bond 4 residues away; the peptide planes are roughly parallel with the helix axis and the dipoles within the helix are aligned, i.e. all C=O groups point in the same direction and all N-H groups point the other way; side chains point outward from helix axis and are generally oriented towards its amino-terminal end.  (from expasy.org)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12786] "Cis-acting locus is a section of DNA that affects the activity of DNA sequences on that same molecule of DNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12787] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12788] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12789] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12790] "Retroviral-like intracisternal A particles.  High copy number family of repeated elements in the mouse with a typical proviral organization.  Expressed very early in mouse development (2-8 cell stage) and in transformed cells.  Mutant alleles of various genes contain newly-integrated IAP genes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12791] "Heritable sensitive regions of chromosomes which show up in vitro as non-staining bands. They are associated with chromosome breakage and other aberrations. No abnormal phenotype has been definitely identified with autosomal fragile sites, but some rare autosomal recessive disorders may be due to homozygosity for fragile sites. A fragile site on the X chromosome is associated with Fragile X Syndrome. Fragile sites are designated by the letters \"fra\" followed by the designation for the specific chromosome and locus."                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12792] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12793] "The 3-D organization of histones and other proteins on chromosomal DNA in the nucleus and allow for its form and function during cellular growth and division."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12794] "The larger part of a hollow organ that is farthest away from the organ's opening. The bladder, gallbladder, stomach, uterus, eye, and cavity of the middle ear all have a fundus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12795] "A protein domain is a functional region of a protein that typically either mediates a homotypic or heterotypic binding interaction with another biomolecule or that exhibits catalytic activity, and consists of a largely conserved amino acid sequence that occurs within related proteins that often perform a similar biochemical function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12796] "Distal (long) arm of chromosome 5"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12797] "Proximal (short) arm of chromosome 8"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12798] "Proximal (short) arm of chromosome 17"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12799] "Distal (long) arm of chromosome 18"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12800] "Distal (long) arm of chromosome 7"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12801] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12802] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12803] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12804] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12805] "Distal (long) arm of chromosome 11"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12806] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12807] "Microsatellite repeats that have been used as markers of microsatellite instability.  BAT26, a poly(A) tract in MSH2 intron 5, is one example of a BAT locus.  Presence of alterations in the BAT26 locus, detected in stool samples, may be an easy and non-invasive detection method for colorectal cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12808] "Proximal (short) arm of chromosome 3"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12809] "A portion of an organ, such as the liver, lung, breast, thyroid, or brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12810] "(mye-eh-LAH-jen-us) Produced by, or originating in, the bone marrow."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12811] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12812] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12813] "A duplex of DNA is formed by two complementary chains that are arranged in an anti-parallel manner. B-DNA is about 20 Angstrom in diameter and a right-handed double helix with a wide major groove easily accessible to proteins and narrow minor groove. B-DNA is the most common DNA conformation in vivo and the favored conformation at high water concentrations. Base pairs are nearly perpendicular to the helix axis and sugar pucker is C2'-endo."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12814] "Fluids surrounding or related to an embryo."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12815] "Anything relevant to all anatomic sites - non-specific."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12816] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12817] "Secretions of the breast, not otherwise specified."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12818] "The more readily stainable portion of the cell nucleus, forming a network of nuclear fibrils within the achromatin of a cell. It is a deoxyribonucleic acid attached to a protein (primarily histone) structure base and is the carrier of genes in inheritance. It occurs in two states, euchromatin and heterochromatin, with different staining properties, and during cell division, it coils and folds to form the chromosomes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12819] "Contractile system directs cell movement and is responsible for maintaining or changing cell shape. The system consists of many specialized cytoplasmic proteins, including actin, myosin, tubulin, kinesin, other cytoskeletal and contractile system proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12820] "It refers to the secondary or tertiary structure of DNA. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12821] "The reactive parts of a macromolecule that directly participate in its specific combination with a drug."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12822] "MYC boxes I and II, found in the N termini of all members of the MYC protein family, function to direct the degradation of the c-MYC protein. Both MYC boxes I and II contain sufficient information to independently direct the degradation of otherwise stably expressed proteins to which they are fused. At least part of the MYC box-directed degradation occurs via the proteasome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12823] "The 3-D structure of peptides."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12824] "Putative DNA/Chromatin Binding Motif 1 is a protein containing three cysteine-rich zinc-binding PHD/LAP domains, a DNA-binding domain found in the Drosophila dead ringer gene product, five putative nuclear localization signals, and other conserved regions of unknown function.  The protein may be expressed as a 170-kD protein in the nucleus and shares 56% overall amino acid sequence identity with RBBP2, which plays an important role in RB tumor suppressor regulation.  (from OMIM 605393 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12825] "Secretions of the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12826] "The portion of an integral membrane protein crossing through the plasma lemma (cell membrane) or that of an internal vesicle. This region is highly hydrophobic, approximately 20 amino acids long, and bordered by charged amino acids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[12827] "Research that isn't focused on a specific site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12828] "Third hypervariable region (V3) of the gp120 HIV envelope protein."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12829] "Considering the organism as a whole"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12830] "(in-tra-VES-ih-kal) Within the bladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12831] "Epinephrine and norepinephrine from the medulla and steroid hormones from the cortex."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12832] "Fluids surrounding connective tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12833] "Secretions and fluids from the area of the body generally construed to comprise base of skull and facial bones, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature and lymph nodes draining these areas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12834] "More than one cancer site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12835] "Present at many sites of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12836] "A protein structural element originally identified in the core histones.  It is of the helix-loop-helix type and is involved in protein-protein interactions via a \"handshake\" motif with a histone fold partner.  Also involved in protein-DNA interactions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12837] "Each HMG subfamily is a distinct set of proteins with identifiable structural characteristics and a specific type of targets to induce characteristic changes in the structure of its binding site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12838] "The POU domain is a bipartite DNA binding domain recognized originally as a shared structural motif in the Pit-1, Oct-1/Oct-2, and Unc-86 transcription factors (POU).  It is comprised by a C-terminal homeo domain, and an N-terminal POU-specific domain, separated by a non-conserved linker.  The POU-specific domain, like the homeo domain, is folded in a helix-turn-helix motif."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12839] "The winged helix is a common, 100 amino acid DNA-binding domain which is a variant of the helix-turn-helix motif found in the \"forkhead\" transcription factor gene family."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12840] "A region of a protein that interacts with DNA. Among the various recognized structural motifs present in DNA binding domains are the helix-loop-helix and the zinc-finger."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12841] "Protein Binding Domains are structural motifs responsible for the peptide/protein binding activity of proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12842] "Zinc-binding, DNA-binding motifs in proteins contain amino acids that are folded into a single DNA-binding structural unit around a zinc atom."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12843] "One of three structural motifs observed in DNA binding domains of zinc proteins.  Originally identified in the glucocorticoid receptor, it's also known as the C4 zinc finger, or the zinc twist.  Each of two zinc atoms is bound to four cysteine residues; the zinc twist is represented by a helical DNA recognition site located between the two zinc atoms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12844] "The zinc cluster is one of three structural motifs observed in the DNA-binding domains of zinc proteins.  In the \"zinc cluster\" two zinc atoms are liganded by six cysteine residues.  Originally identified in the GAL4 transactivator, it is also known as the C6 zinc cluster, binuclear cluster, and the Zn(II)2Cys6 motif."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12845] "Condensed chromosomes observed during the M phase of the cell cycle.  Individual chromosomes can be discerned and differentiated morphologically."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12846] "Interphase chromosomes are decondensed chromosomes that reside in the interphase nucleus in the form of chromatin. Two types of chromatin, euchromatin and heterochromatin, can be discerned microscopically."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12847] "Chromosomal bands observed after staining with specific dyes.  The band pattern is the result of differential interactions between the dye and nonadjacent chromosomal regions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[12848] "A level of DNA packaging in chromatin above that of the nucleosome, the fundamental subunit of chromatin structure.  The chromatin fiber has a thickness of about 30 nanometers and results from the folding of a linear array of nucleosomes (thickness about 10 nm) into a more compact fiber."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12849] "Refers to various levels of DNA packaging in the chromosomes above that of the nucleosome.  Includes the chromatin fiber and higher levels of folding such as loops."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12850] "A higher order chromatin structure above the level of the chromatin fiber.  The organization of chromatin into loops permits the partitioning of chromatin into topologically independent domains, and is thought to facilitate its compartmentation into functionally independent regions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12851] "The physical volume occupied by a specific chromosome in the interphase nucleus.  The territories from distinct chromosomes do not appear to overlap, preventing an intermingling of the decondensed chromatin.  Relative to a nuclear landmark (e.g. nucleolus), chromosome territories appear to differ from cell to cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12852] "Regions of chromosomal DNA attached to a structural component of the interphase nucleus termed the nuclear matrix, permitting the partitioning of DNA in the chromosomes into looped chromatin domains."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[12853] "The death domain is a protein region, approximately 80 amino acids long, that is required for transmission of the cytotoxic signal of apoptosis and is present in the TNF receptor, FAS, and several downstream signaling molecules.  Transmission of the apoptotic signal requires the functional interaction of proteins via the death domain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12854] "The TRAF domain is the portion of TRAF family adaptor proteins which bind to TNF receptor cytopasmic domain. It is the C-terminal homology region of 230 amino acids of signal-transducing proteins associated with members of the TNFR superfamily. This domain is involved in a variety of specific protein-protein interactions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[12855] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12856] "Short tandem repeats are multiple, end-to-end copies of a short DNA sequence usually comprised of di-, tri-, or tetranucleotide repeat units."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[12857] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12858] "Immunoglobulin genes are formed by somatic recombination of multiple gene elements. Light chains use variable (V) and joining (J) elements, whereas heavy chains incorporate an additional diversity (D) element between the V and J elements."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[12859] "Either the hard, calcified (bone) or more flexible and compressible (cartilage) tissue of the skeleton"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[12860] "The structural organization of a gene in DNA.  Refers to the arrangement of elements that comprise a gene or transcription unit, among which are the transcription initiation site, the protein coding sequences, intervening sequences in the case of split genes, and the transcription termination or polyadenylation sites.  Can be extended to include the regulatory elements (enhancers, silencers, and the promoter) that lie outside the boundaries of the transcribed unit."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12861] "Any structures that are enclosed within nucleus are considered nuclear structure, including any macromolecular structures. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12862] "Tubulin contains two sites for binding of guanine nucleotides. The nonexchangeable or N-site at which GTP or GDP is permanently bound is located on the alpha subunit. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12863] "It is the aggregated products of microtubules during mitosis where chromosomes line up prior to the segregation process. Many antineoplastic agents cause cytotoxicity by inducing microtubular bundle formation irreversibly. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12864] "Related to the secondary level of structural organization of RNA.  RNA can be found in various conformations, including double- as well as single-stranded, and in loops."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12865] "The bHLH domain is a bipartite DNA-binding domain containing a basic region upstream of an amphipathic helix-loop-helix region. The basic region interacts with DNA and the HLH motif mediates protein dimerization."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12866] "It refers to the chromosome status during the prophase of mitotic division. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12867] "Liquid substances produced by living organisms to fulfill specific functions or excreted as waste. Secretions do not include hormones or enzymes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12868] "The specific parts of a macromolecule that directly participate in its interactions with a metal ion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12869] "An epitope composed of adjacent animo acids"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[12870] "Sister chromatids are the two newly synthesized daughter chromatids derived from the same chromosome parent.  During chromosomal pairing in meiosis, recombination can ocurr between sister or non-sister chromatids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12871] "Primitive blood cells residing in the bone marrow, derived from embryonic mesenchyme, and capable of differentiating into any of the blood cell line progenitor cells (erythroblasts, young granulocytic series cells, megakaryocytes, etc.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[12872] "The part of a transmebrane protein which projects into the cytoplasm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12873] "The part of a transmebrane protein which projects into the environment surrounding a cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12874] "The portion of a proteolytic protein which causes hydrolysis and cleavage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[12875] "Enhancer sequences found nearby to the gene it regulates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12876] "Enhancer sequences found at a distance from the gene it regulates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12877] "An enhancer which is located 5' of the gene it regulates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12878] "An enhancer which is located 3' of the gene it regulates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[12879] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12880] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12881] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12882] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12884] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12885] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12886] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12887] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12888] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12889] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12891] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12892] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12893] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12894] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12895] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12896] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12897] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12898] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12899] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12900] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12901] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12902] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12903] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12906] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12907] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12910] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12911] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12912] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12913] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12914] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12915] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12916] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12917] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12918] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12919] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12920] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12922] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12923] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12924] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12927] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12928] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12929] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12932] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12933] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12934] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12935] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12936] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12937] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12938] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12939] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12940] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12941] "Proximal (short) arm of chromosome 1"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12942] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12943] "Distal (long) arm of chromosome 1"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12944] "Proximal (short) arm of chromosome 11"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12945] "Proximal (short) arm of chromosome 10"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12946] "Distal (long) arm of chromosome 10"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12947] "Proximal (short) arm of chromosome 12"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12948] "Distal (long) arm of chromosome 12"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12949] "Distal (long) arm of chromosome 13"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12950] "Proximal (short) arm of chromosome 13"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12951] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12952] "Proximal (short) arm of chromosome 14"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12953] "Distal (long) arm of chromosome 14"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12954] "Distal (long) arm of chromosome 15"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12955] "Proximal (short) arm of chromosome 15"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12956] "Proximal (short) arm of chromosome 16"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12957] "Distal (long) arm of chromosome 16"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12958] "Distal (long) arm of chromosome 17"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12959] "Proximal (short) arm of chromosome 18"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12960] "Proximal (short) arm of chromosome 19"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12961] "Distal (long) arm of chromosome 19"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12962] "Proximal (short) arm of chromosome 2"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12963] "Distal (long) arm of chromosome 2"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12964] "Distal (long) arm of chromosome 20"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12965] "Proximal (short) arm of chromosome 20"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12966] "Proximal (short) arm of chromosome 21"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12967] "Distal (long) arm of chromosome 21"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12968] "Distal (long) arm of chromosome 22"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[12969] "Proximal (short) arm of chromosome 22"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[12970] "Distal (long) arm of chromosome 3"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12971] "Distal (long) arm of chromosome 4"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12972] "Proximal (short) arm of chromosome 4"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12973] "Proximal (short) arm of chromosome 5"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12974] "Proximal (short) arm of chromosome 6"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12975] "Distal (long) arm of chromosome 6"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12976] "Proximal (short) arm of chromosome 7"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12977] "Distal (long) arm of chromosome 8"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12978] "Proximal (short) arm of chromosome 9"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12979] "Distal (long) arm of chromosome 9"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12980] "Proximal (short) arm of chromosome X"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[12981] "Distal (long) arm of chromosome X"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[12982] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12984] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12985] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12986] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12988] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12991] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12993] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12994] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12995] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12998] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[12999] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13001] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13002] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13004] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13005] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13007] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13008] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13009] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13010] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13011] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13012] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13013] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13014] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13015] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13016] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13017] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13018] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13019] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13020] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13021] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13022] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13023] "Location of RB1 Gene.  Chromosomal band . Chromosome 13, long arm (q), band 14 subdivision 2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13024] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13025] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13026] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13027] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13028] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13029] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13030] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13031] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13032] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13033] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13034] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13035] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13036] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13037] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13038] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13039] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13040] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13041] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13042] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13043] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13044] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13045] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13046] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13047] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13048] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13049] "A cis-acting transcription regulatory element.  It is bound by the retinoic acid receptors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[13050] "Tripartite DNA binding domain containing a basic region, a helix-loop-helix, and a leucine zipper."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13051] "Bipartite DNA binding domain containing a homeo domain and a leucine zipper."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13052] "Bipartite DNA binding domain containing a helix-turn and a leucine zipper."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13053] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13054] "The site within the 3' untranslated region of a gene where polyadenylation of the transcribed RNA takes place.  Usually consists of the sequence AATAAA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13055] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13056] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13057] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13058] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13059] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13060] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13061] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13062] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13063] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13064] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13065] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13066] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13067] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13068] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13069] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13070] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13071] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13072] "Nucleosomal repeat length is approximately 200 base pairs of DNA within which 146 base pairs are highly protected. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13073] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13074] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13075] "The point on a chromosome where the normal DNA sequence is juxtaposed with DNA from another chromosome.  Usually expressed as a band number designation (eg. t(9;22) (q34;q11) Philadelphia Chromosome)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13076] "A promoter sequence which interacts with CRE binding proteins to modulate gene expression in response to the level of cAMP in the cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13077] "Androgen response element is the target binding element for activated androgen receptor homodimer.  The consensus sequence for this high-affinity androgen receptor-binding is the palindromic sequence GGT/AACAnnnTGTTCT, though could deviate considerably in natural promoter sequences.  The most well-characterized in this regard is the promoter of the PSA (prostate-specific antigen) gene.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13078] "The SANT domain is found in several transcriptional regulatory proteins identified through consistent homology to the c-MYB repeat DNA binding domain, suggesting that SANT domains also bind DNA. Folded into three alpha helices as doublets or singlets in many proteins, the SANT domain family specifically recognizes the sequence YAAC(G/T)G. The SANT domain is a repeated motif in N-CoR, the nuclear receptor co-repressor. Single copies of SANT occur in yeast nuclear chromatin remodeling proteins SWI3 (SWI/SNF transcription subunit), ADA2 (ADA adaptor/HAT complex), and a TFIIIB transcription subunit. SANT domains may mediate functional interactions with histone N-terminal tails. (NCI)"                                                                                                                                                                                                                                                                                   
[13079] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13080] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13081] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13082] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13083] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13084] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13085] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13086] "A Binding Site Domain is a region of protein that physically interacts stereospecifically, and usually at high affinity, with a specific ligand, substrate, or a specific domain of some complex target biomolecule, such as a protein, lipid, carbohydrate, or nucleic acid. Typically, but not necessarily, the interaction results in protein conformational alteration and functional modification. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13087] "The LIM domain is a zinc binding, cysteine rich motif consisting of two tandemly repeated zinc fingers. Unlike GATA type zinc fingers, LIM domains do not bind DNA but instead mediate protein-protein interactions. Functionally, LIM domain containing proteins have been implicated in cell lineage specification, cytoskeletal organization, and organ development."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13088] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13089] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13090] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13091] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13092] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13093] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13094] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13095] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13096] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13097] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13098] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13099] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13100] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13101] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13102] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13103] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13104] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13105] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13106] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13107] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13108] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13109] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13110] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13111] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13112] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13113] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13114] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13115] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13116] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13117] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13118] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13119] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13120] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13121] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13122] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13123] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13124] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13125] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13126] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13127] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13128] "Sperm and the fluid it is suspended in"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[13129] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13130] "Internal ribosome entry site (IRES) is a translational cis-acting element that directs ribosomes to the start codon by a cap-independent mechanism.  IRESs are usually about 450 nucleotides in length and were first identified in picornavirus RNAs.  IRESs can fold into a stable secondary hairpin structure to be incompatible with efficient translation by ribosomal scanning. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[13131] "Named locations of, or within, the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13132] "DNA sequences in a gene's promoter region that mediate expression during hypoxia.  Since unlike normal tissues, solid tumors frequently have regions of hypoxia, suicide genes controlled by hypoxia-responsive elements may provide a means for cancer-specific gene therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13133] "Usually C-terminal, the conserved ETS (Erythroblast Transformation Specific) Domain of 85-90 amino acids, rich in positively-charged and aromatic residues, binds to purine-rich DNA with a GGAA/T core. Identified in many transcription factors, many ETS-proteins modulate gene expression through protein-protein interactions with other transcriptional factors and co-factors. Most ETS-proteins are nuclear targets of RAS-MAPK signaling; some affect cell proliferation or apoptosis-related genes. Several are expressed in specific cell lineages to regulate development and differentiation. Deregulated ETS-gene expression or chimeric ETS-proteins are associated with leukemias, some tumors, invasion and metastasis. (NCI)"                                                                                                                                                                                                                                                     
[13134] "RNA Binding Domains, such as the RRM, RGG box, and KH domain, mediate the interaction of RNAs with RNA-binding proteins. RRMs of about 90 amino acids consist of a four-stranded beta sheet adjacent to two alpha helixes. Within RRMs, conserved RNP-1 and RNP-2 motifs on the central beta sheets lie side by side; their side chains contact RNA. Found in hnRNP proteins, the RGG box is an RNA-binding motif containing five Arg-Gly-Gly repeats with intervening aromatic residues. The KH domain is found in several RNA-binding proteins in multiple repeats interspersed with RGG boxes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                            
[13135] "Bipartite DNA binding domain containing a basic region directly interacting with DNA, and a leucine zipper mediating dimerization through contacts with a protein partner."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13136] "Fluids and secretions relating to the respiratory system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13137] "Initial or intermediate protein-DNA complexes present during the process of DNA repair."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13138] "In Lentivirus, a central strand displacement event consecutive to central initiation and termination of plus strand synthesis creates a plus strand overlap: the central DNA flap.  This feature promotes efficient nuclear import and viral replication in non-dividing cells. (from Cell 2000;101:173-85)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[13139] "G-quadruplexes are multi-stranded structures held together by square planes of four guanines ('G-quartets') interacting by forming Hoogsteen hydrogen bonds. G-quartet structures has been developed as novel anti-HIV agents. Several critical structure-activity relationships between HIV-1 integrase and G-quartet oligonucleotides have been demonstrated."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13140] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13141] "t(12;21) is a chromosomal translocation, involved in TEL-AML1 oncogene formation, that produces a chimeric gene encoding a protein consisting of the N-terminal HLH domain of the TEL ETS-like transcription factor fused with a nearly complete AML1 protein. t(12;21) is the most frequent translocation causing ALL, accounting for 20% of ALL cases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13142] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13143] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13144] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13145] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13146] "A motif common in chromatin remodeling factors. It constitutes an acetyl-lysine binding domain. Bromodomain-containing proteins may recruit remodeling complexes to acetylated chromatin regions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13147] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13148] "Any DNA sequence involved in the regulation of genetic processes such as transcription and replication."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13149] "The semipermeable membrane that encloses the cytoplasm of a cell. Also called cytomembrane, plasmalemma, plasma membrane.(The American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[13150] "The best understood cell-cell junction required for adhesion between cells in the epithelium. It seals adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. Adherens junctions are located most apically in insect cells and just basal to the tight junction in vertebrate cells. It is formed by the fusion of adjacent cell membranes which encircle the apical cell surface like a belt or fence based on homophilic association between molecules of the transmembrane protein E-cadherin, which is linked on its cytoplasmic side to the actin cytoskeleton via b-catenin (Drosophila Armadillo) and a-catenin. The adherens junctions and associated cytoskeleton form a continuous band (zonula adherens) around the apical circumference of each cell, thus uniting the cells of the epithelium into a coherent sheet."                                                                              
[13151] "The 20S proteasome, as proteolytic core of the proteasome system, is essential in ATP dependent ubiquitin protein complex degradation and in antigen processing in antigen presenting cell. It has 13-15 subunits each of which has three or four different peptidase activities. 26S proteasomes may be formed in an ATP dependent fashion from a 20S proteasome and additional components, CF1 (660 kD), CF2 (250 kD) and CF3 (600 kD). The 20S proteasome interacts with additional subunits, PA700 and PA28, to form an ATP-dependent multicatalytic proteinase complex (MPC) involved in the ATP ubiquitin degradation pathway."                                                                                                                                                                                                                                                                                                                                                               
[13152] "The characteristic three-dimensional shape of a molecule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13153] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13154] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13155] "Highly conserved peptide motifs of the HMG-I(Y) proteins that preferentially bind, in vivo and in vitro, to the narrow minor groove of stretches of AT-rich DNA. The AT Hook Motif tethers and unbends the minor groove of the DNA with very little specificity for the DNA sequence. The AT hook motif has a narrow DNA recognize surface which is devoid of hydrophobic amino acids and does not significantly distort the B-form DNA structure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13156] "The smaller of the two types of spiral grooves found on a right-handed DNA double helix; located between the sugar phosphate backbones of two DNA strands."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13157] "One of the two types of grooves found in a right-handed double helix, running between the sugar phosphate backbones of each strand."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13158] "The HMG-Box Domain binds to and bends the minor groove of the DNA. This domain can recognize and bind to altered DNA conformations, such as stem-loops, four-way junctions, and specifically kinked or underwound DNA. (Mol Cell Biol 1999 Aug;19(8):5237-46)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13159] "The Nucleosomal Binding Domain anchors HMG-14 and HMG-17, two canonical HMG proteins, to nucleosomes. HMG-14 and HMG-17 are the only nuclear proteins known to specifically recognize the genetic structure of the 146-bp nucleosome, i.e., the building block of the chromatin fiber. Althugh the target of HMG-14/-17 is the nucleosome, the main function of these proteins is to change the architecture of the higher-order chromatin structure. These changes are mediated through the C-terminal region of the proteins. The nucleosomal binding domain anchors these HMG proteins to the nucleosome cores to facilitate HMG-14/-17-dependent changes in chromatin structure."                                                                                                                                                                                                                                                                                                               
[13160] "RING finger domains are defined by the consensus sequence CX2CX(9-39)CX(1-3)HX(2-3)C/HX2CX(4-48)CX2C with the Cys and His representing zinc binding residues. RING fingers are further divided into RING-HC and RING-H2, depending on whether a Cys or His occupies the fifth coordination site. While RING fingers are structurally diverse, all contain two interleaved Zn2+ binding sites. Binding of the Cbl RING domain to the E2 protein, UbcH7, occurs between a groove within the RING domain and two loops in the E2 fold of UbcH7. Van der Waals interactions involving hydrophobic residues in both the E2 and RING domains support the Cbl-UbcH7 binding, though this is not universal as the RING-E2 pair of Rad18p and Rad6p/Ubc2p interact by hydrogen bonding of polar residues."                                                                                                                                                                                                   
[13161] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13162] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13163] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13164] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13165] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13166] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13167] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13168] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13169] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13170] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13171] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13172] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13173] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13174] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13175] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13176] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13177] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13178] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13179] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13180] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13181] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13182] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13183] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13184] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13185] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13186] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13187] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13188] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13189] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13190] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13191] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13192] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13193] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13194] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13195] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13196] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13197] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13198] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13199] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13200] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13201] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13202] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13203] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13204] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13205] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13206] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13207] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13208] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13209] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13210] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13211] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13212] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13213] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13214] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13215] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13216] "In a b-sheet two or more polypeptide chains run alongside each other and are linked in a regular manner by hydrogen bonds between the main chain C=O and N-H groups. The R-groups (side chains) of neighbouring residues in a b-strand point in opposite directions; beta sheets can be parallel, anti-parallel or mixed. (from expasy.org)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[13217] "LINEs.  Highly repeated sequences, 6000-8000 base pairs in length that contain RNA polymerase II promoters.  They also have a region with sequence similarity to the reverse transcriptase of retroviruses, but they do not contain LTRs (long terminal repeats)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13218] "SINEs.  Short, 100-300 bases long, highly repeated sequences which contain RNA polymerase III promoters. The primate Alu and the rodent B1 SINEs are derived from 7SL RNA, the RNA component of the signal recognition particle. Most other SINEs are derived from tRNAs including the MIRs (mammalian-wide interspersed repeats)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13219] "1) Reddish in color. 2) relating to erythrocytes or their precursors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13220] "The major histocompatibility complex (MHC) molecules are made of 2 chains, alpha and beta. In class I, the alpha chain is composed of 3 extracellular domains, a transmembrane region and a cytoplasmic tail while the beta chain is of a single extracellular domain. In class II, both the alpha and the beta chains are composed of 2 extracellular domains, a transmembrane region and a cytoplasmic tail. The immunoglobulin (Ig) constant chain domains and a single extracellular domain in each type of MHC chains are homologous and approximately one hundred amino acids long, and include a conserved intra-domain disulfide bond. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions, e.g., antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. (InterPro IPR007110)"                                             
[13221] "(in-tra-eh-pih-THEEL-ee-ul) Within the layer of cells that form the surface or lining of an organ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13222] "(in-tra-hep-AT-ik) Within the liver."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13223] "The nuclear lamina is a proteinaceous filamentous meshwork of lamin proteins interacting with integral proteins of the inner nuclear membrane, including emerin, and is thought to play a role in nuclear stability, chromatin structure, and gene expression. Lamins are highly conserved in evolution and members of the intermediate filament protein family. Mammalian lamins are classified into two major types, A and B, with two subspecies of each: lamins A and C for the A type and B1 and B2 for the B type. Lamins A and C arise from one gene by alternative splicing. Pre-lamin A contains a carboxyl CAAX box that can be modified by farnesylation. During mitosis, the lamina meshwork is reversibly disassembled in parallel with phosphorylation of the lamins."                                                                                                                                                                                                                
[13224] "(LIM-foyd) Referring to lymphocytes, a type of white blood cell. Also refers to tissue in which lymphocytes develop."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13225] "Nucleosome core particle consists of the 146 base pair highly protected DNA segment and its bound histone octamer (two of each histones H2A, histone2B,, H3 and H4). Nucleosome core particle, linker DNA and histone H1 comprise one structural unit of chromatin, nucleosome. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13226] "Regions of chromosomal DNA attached to structural components of metaphase (condensed) chromosomes, permitting the partitioning of DNA in the chromosomes into looped domains.  Appear to be related to similar regions denoted matrix-attachment regions that partition the chromosomal DNA in interphase chromosomes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[13227] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13228] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13229] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13230] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13231] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13232] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13233] "Nerve endings encased in connective tissue capsules with myelinated or unmyelinated axons."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13234] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13235] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13236] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13237] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13238] "The Muscle Spindle is composed of intrafusal fibers that are located within and run parallel to the extrafusal fibers of skeletal muscle. When the extrafusal fibers are stretched, the intrafusal fibers of the spindle stretch as well. When stretching occurs, the sensory neuron from the muscle spindle signals the motor neurons located within the ventral horn of the spinal cord. This signal causes the motor neurons to fire, resulting in contraction of the muscle. This reflex arc provides negative feedback. The muscular contraction induced by the stretching works against or negates further muscle stretch. This mechanism helps to maintain proper muscle tension or tone. Although the muscle spindle helps to maintain proper muscle tension, unlike the Golgi tendon organ, it is not an indicator of muscle tension, but rather of muscle length."                                                                                                                        
[13239] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13240] "The Golgi Tendon Organ is located within the tendons found on each end of a muscle. It responds to increased muscle tension or contraction as exerted on the tendon, by inhibiting further muscle contraction, which protects against muscle damage. The proprioceptive sensory neuron of a Golgi tendon organ, projects to the motor neurons located within the ventral horn of the spinal cord, where the inhibition occurs. Unlike the muscle spindle, Golgi tendon organs do not indicate muscle length, but rather muscle tension."                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13241] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13242] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13243] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13244] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13245] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13246] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13247] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13248] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13249] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13250] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13251] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13252] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13253] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13254] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13255] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13256] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13257] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13258] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13259] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13261] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13262] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13263] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13264] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13265] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13266] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13267] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13268] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13269] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13270] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13272] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13273] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13274] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13276] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13277] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13278] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13279] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13280] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13281] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13282] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13283] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13284] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13285] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13286] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13287] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13288] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13289] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13290] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13291] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13292] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13293] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13294] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13295] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13296] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13297] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13298] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13299] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13300] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13301] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13302] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13303] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13304] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13305] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13306] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13307] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13308] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13309] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13310] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13311] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13312] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13313] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13314] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13315] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13316] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13317] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13318] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13319] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13320] "Containing perfectly conserved histidine and cysteines residues. the BIR domain is about 70 residues long arranged in tandem repeats separated by a linker of variable length. Found in IAP (Inhibitor of Apoptosis Protein) Family proteins, it seems to confer cell death-preventing activity. Except NAIP, family members typically contain two or three BIR repeats and a C-terminal RING finger. A second group of BIR-domain-containing proteins (BIRPs) include mammalian Bruce and Survivin proteins, as well as BIR-containing proteins in yeasts and C. elegans. Survivin-like BIRPs regulate cytokinesis and mitotic spindle formation. (NCI)"                                                                                                                                                                                                                                                                                                                                           
[13321] "The 16-kD UBC domain contains a conserved UBC motif and a conserved cysteine that accepts activated ubiquitin from E1 enzyme to form a thiol ester. Basic residues at the UBC domain N-terminus may be involved in E1 binding. UBC/E2 enzymes catalyze ubiquitination of target proteins with or without E3 'N-end' recognizing proteins. E2s can be classified on the basis of UBC structure. Poor at transferring ubiquitin to proteins on their own, Class I proteins comprise simply the UBC domain and probably require an E3 to ubiquitinate short-lived abnormal proteins prior to degradation. Class II enzymes contain different acidic C-terminal extensions of the UBC domain that appear to involve cellular localization or to mediate interaction with protein substrates for ubiquitination that results in protein modification but not degradation. Class III E2s have N-terminal extensions, but their function is unknown. (NCI)"                                                
[13322] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13323] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13324] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13325] "Proteins that are related to bcl-2 are characterized by the presence of one or more highly conserved stretches of homology with bcl-2, designated BH1, BH2, BH3, BH4 . These domains control the ability of these proteins to homo- and heterodimerize with other proteins. Competitive dimerisation between family members is thought to regulate their function as regulators of apoptosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13326] "Found in proteins that regulate apoptosis, conserved a-helix BCL-2 Homology (BH1-4) Domains are critical to protein apoptotic function and the protein ability to interact/dimerize with other family members or regulatory proteins. BH1 contains predominantly hydrophobic residues. BCL-2 family proteins dimerize among pro- and anti-apoptotic class family members. BCL-2 homodimerization appears to involve head-to-tail interaction of N-terminal BH4 resides with more distal BH1, BH2, and BH3 regions. BCL-2/BAX heterodimerization appears to involve tail-to-tail interaction of the BCL-2 BH1, BH2, and BH3 regions and the BAX BH3 domain region. BCL-2 may suppress cell death partly by binding to BAX via the BH3 domain preventing BAX homodimer formation. (NCI)"                                                                                                                                                                                                              
[13327] "Found in proteins that regulate apoptosis, conserved a-helix BCL-2 Homology (BH1-4) Domains are critical to protein apoptotic function and the protein ability to interact/dimerize with other family members or regulatory proteins. BCL-2 family proteins dimerize among pro- and anti-apoptotic class family members. BCL-2 homodimerization appears to involve head-to-tail interaction of N-terminal BH4 resides with more distal BH1, BH2, and BH3 regions. BCL-2/BAX heterodimerization appears to involve tail-to-tail interaction of the BCL-2 BH1, BH2, and BH3 regions and the BAX BH3 domain region. BCL-2 may suppress cell death partly by binding to BAX via the BH3 domain preventing BAX homodimer formation. (NCI)"                                                                                                                                                                                                                                                               
[13328] "The alpha-helical BH3 domain (9 amino acids) represents a minimal death domain and is essential for the activity of pro-apoptotic members of the bcl-2 family. Some of these proteins only contain a BH3 domain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13329] "BH4 is present only in the amino-terminal regions of pro-survival family bcl-2 members and is essential for the anti-apoptotic function, although deletion of BH4 does not necessarily impair the ability of BH4-containing proteins to bind to a variety of other bcl-2-related proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13330] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13331] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13332] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13333] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13334] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13335] "The WAP (Whey Acidic Protein) Domain contains eight characteristically-spaced cysteine residues involved in disulphide bond formation and occurs in so-called 'four-disulphide core' proteins. The spatial pattern of these conserved domain cysteines suggests that the otherwise variable domain sequences may adopt a similar fold. The overall degree of domain sequence similarity is low; a few Pro and Gly residues are reasonably well conserved, as are polar/acidic residues between Cys3 and Cys4. WAP sequences are found in Whey Acidic Protein; Elafin (a human skin elastase-specific inhibitor); rat WDNM1 Protein (involved in metastatic potential); Kallmann Syndrome Protein; and guinea pig Caltrin-Like Protein II (inhibits calcium transport into spermatozoa). (NCI)"                                                                                                                                                                                                      
[13336] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13337] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13338] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13339] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13340] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13341] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13342] "Evolutionary related to desmosomal desmogleins, cadherins contain a signal sequence, a propeptide of around 130 residues, an extracellular domain of around 600 residues, a single transmembrane domain, and a well-conserved C-terminal cytoplasmic domain of about 150 residues. The extracellular domain typically consists of four Cadherin Domain repeats of about 110 residues; an adjacent fifth domain contains four conserved cysteines. The domain includes conserved Asp and Arg residues that may be involved in calcium binding. Tissue-specific cadherin glycoproteins are responsible for homophilic calcium-dependent cell-cell adhesion likely involved in cell type sorting during morphogenesis, histogenesis, and regeneration. They may also regulate tight and gap junctions. (NCI)"                                                                                                                                                                                          
[13343] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13344] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13345] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13346] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13347] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13348] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13349] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13350] "A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF) has been shown to be present, in a conserved form, in a large number of other, mostly animal proteins. The list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied. The functional significance of EGF domains in what appear to be unrelated proteins is not yet clear. However, a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in disulfide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet. Subdomains between the conserved cysteines vary in length. (InterPro IPR006209)"                                          
[13351] "It is an integrin binding domain originally identified in ADAM family proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13352] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13353] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13354] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13355] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13356] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13357] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13358] "The FHA (Forkhead-Associated) domain is a phosphopeptide recognition domain found in many regulatory proteins. It displays specificity for phosphothreonine-containing epitopes but will also recognize phosphotyrosine with relatively high affinity. It spans approximately 80-100 amino acid residues folded into an 11-stranded sandwich, which sometimes contain small helical insertions between the loops connecting the strands. To date, genes encoding FHA-containing proteins have been identified in eubacterial and eukaryotic but not aracheal genomes. The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake in many different cellular processes. DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples. (From Pfam PF00498)"                                                                               
[13359] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13360] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13361] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13362] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13363] "The nuclear contents other than the nucleolus. (from On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13364] "Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC). NPC is comprised of approximately 50 unique proteins collectively known as nucleoporins. NPC functions in the nuclear transport of protein and RNA. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13365] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13366] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13367] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13368] "Desmosomes are intercellular anchoring junctions that anchor intermediate filaments at membrane-associated plaques in adjoining cells.  Desmosomes assemble in response to cell-cell contact and raised levels of extracellular calcium. Sensitivity to calcium levels is lost as desmosomes mature.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13369] "Forming a single Ca2+-binding site in many calcium-binding proteins, the basic EF-Hand Domain consists of a conserved 12-residue loop region between two perpendicular 10-12 residue alpha helices (helix-loop-helix). Ca2+ interacts with loop residues in a pentagonal bipyramidal configuration; each loop residue is important for Ca2+ coordination. Loop residues 1, 3, 5, 7, 9, and 12 (invariant Glu or Asp) are directly necessary for Ca2+ binding. Amino-acid variations at positions 1, 3, 5, 7, and 9 alter ion affinity. Single or multiple domains cause structural/functional variations. EF-hand Proteins are grouped into either regulatory/signaling or structural/buffering/transport categories. Ca2+ binding to regulatory proteins induces conformational/functional change; Ca2+ binding to structural proteins seems to provide a Ca2+ buffer. (NCI)"                                                                                                                      
[13370] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13371] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13372] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13373] "The approximately 70 amino acid SAM (Sterile Alpha Motif) domain has been identified in over 400 different proteins with diverse cellular function, from yeast to man. SAM domains have been implicated in mediating protein-protein interaction via the formation of homo and hetero-typic oligomers. The residues at the interface of the EphA4 and EphB2 SAM domain homodimers have been mapped, but the factors that determine specificity remain to be determined. (Pawson Lab, SLRI, Mount Sinai Hospital, 2003)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[13374] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13375] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13376] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13377] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13378] "Domain found in various secretory polypeptides that has highly conserved cysteine residues that are disulfide bonded in such a way as to generate a trefoil structure (bonded 1-5, 2-4, 3-6). There are also highly conserved A, G and W residues. (The Dictionary of Cell and Molecular Biology - Online)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13379] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13380] "The coiled-coil domain stabilizes alpha helices in proteins, through a very efficient burial of hydrophobic side chains so that polar water molecules do not access them. As a result, the helices are quite stable. In fact, many structural proteins (keratins, tropomyosin, laminin) that have to bear considerable stress have a coiled-coil domain. Two basic essential features are common: (1) the overall secondary structure is alpha helical, (2) the hydrophobic residues are arranged on one side of the helices. The typical positioning of the hydrophobic residues in the coiled-coil domain can be often recognized from primary structure of the protein. The helices can be parallel or antiparallel. The former is common when the helices belong to different polypeptides and the latter prevails in coiled coils made up from a single polypeptide chain. The number of helices in the coil varies usually between 2 and 4. (From http://www.cryst.bbk.ac.uk)"                
[13381] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13382] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13383] "Proteasomes are large multicatalytic proteolytic complexes found in all eukaryotic cells, and simpler forms have been found in archaebacteria and certain eubacteria.  In eukaryotes, the 20S proteasome also exists as the central core of the 26S (2000 kDa) proteasome complex, which catalyzes the degradation of ubiquitin-conjugated proteins and contains an additional 19S complex, composed of regulatory proteins and six ATPases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13384] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13385] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13386] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13387] "The TRIM motif includes three cysteine-rich zinc-binding domains, a RING finger, a B-box, and a coiled-coil region. The order of the sub-domains is conserved, with the RING finger, B-box and coiled -coil domains arranged from the N to C-terminus. However, the number of B-boxes can vary. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13388] "The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. RSXpSXP Motif is one of two different binding motifs that are present in nearly all known 14-3-3 binding proteins. The14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13389] "The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. RXY/FXpSXP Motif is one of two different binding motifs that are present in nearly all known 14-3-3 binding proteins. The14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13390] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13391] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13392] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13393] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13394] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13395] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13396] "Cell junction is the specialized focal contact between cell-cell or cell-matrix in all tissues.  Cell junctions have various functions either communication, anchoring or organization.  There are specific protein associated with subtype of cell junctions and most of the junctions are too small to be resolved by light microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13397] "Anchoring junctions typically are observed as \"spot welds\" between cells in many types of epithelia. Detail sturtures can be seen only with EM. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13398] "Fascia adherens, similar to a zonula adherens, is a half Z line found in the cardiac muscle as one of the three intercalated disks.  They anchor actin filaments from terminal sarcomeres and transmit contractile force between myocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13399] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13400] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13401] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13402] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13403] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13404] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13405] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13406] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13407] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13408] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13409] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13410] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13411] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13412] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13413] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13414] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13415] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13416] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13417] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13418] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13419] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13420] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13421] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13422] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13423] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13424] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13425] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13426] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13427] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13428] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13429] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13430] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13431] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13432] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13433] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13434] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13435] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13436] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13437] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13438] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13439] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13440] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13441] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13442] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13443] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13444] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13445] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13446] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13447] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13448] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13449] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13450] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13451] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13452] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13453] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13454] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13455] "BRCT domain was first identified in C-terminal domain of breast cancer associated protein and was found in many proteins that regulate the cellular response to DNA repair, where these domains act as multi-purpose protein-protein interaction modules. Crystallography study reveals that two ~95 amino acid BRCT repeats within the domain adopt similar structures that pack together in a head-to-tail arrangement. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13456] "The ATP binding cassette (ABC) is the largest protein family known and many of its members are membrane proteins (ABC transporters) active in the transport of a wide variety of substances across membranes. ABC proteins are identified by the presence of one or two cytosolically oriented ATP-binding cassettes or nucleotide-binding domains (NBD) of about 200 amino acid residues. Each NBD contains three typical motifs: the Walker A motif, GX4GK(ST), the Walker B motif and the ABC signature or C motif. Walker A and B motifs are found in other nucleotide-binding proteins, including P-, F- and V-ATPases, G proteins, adenylate kinase, myosin, phosphofructokinase and ATP/ADP exchangers. Although the overall similarity between ABC proteins can be very low, their NBDs share an average of 30-40 % similarity. (From http://www.arabidopsisabc.net/intro.asp)"                                                                                                             
[13457] "Around 70 amino acids and weakly conserved, the PWWP Domain is named after a conserved Pro-Trp-Trp-Pro motif often found as multiple copies in proteins that contain chromatin-association domains or in cell growth and differentiation transcription factors, such as WHSC1 (C-terminus) and ASH1/Trithorax Group proteins. Although its function is unknown, the amino acid composition suggests that it may be involved in protein-protein interactions. The domain N-terminal half resembles a barrel-like five-stranded structure; the C-terminal half contains a five-helix bundle. The halves form a module that exhibits positive electrostatic potential. Alone, the domain binds DNA in vitro, probably through its basic surface. (NCI)"                                                                                                                                                                                                                                                
[13458] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13459] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13460] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13461] "ITAM (Immunoreceptor Tyrosine-based Activation Motif) or ARAM (Ag Recognition Activation Motif) (Y-X-X-L-(X)6-8-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain, e.g. in CD247/x chain, FceRI g chain, or DAP12. Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases. Motif may be dually phosphorylated on tyrosine that links antigen receptors to downstream signaling machinery. (From Pfam PF0218 and9http://digilander.libero.it/danielefocosi/proteindomains.html)"                                                                                                                                                                                                                                                                                                                                                                                                                            
[13462] "ITIM (immunoreceptor Tyr-based inhibition motif) (I/V-X-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain in SHP1 and SHP2, e.g., in KIR family. (http://digilander.libero.it/danielefocosi/proteindomains.html)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13463] "It refers to amino acid residues within a peptide that act as acceptors for any modifications that do not happen concurrent with translation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13464] "It refers to amino acid residue within a peptide that accepts oligosaccharide via amide linkage, specifically through amide nitrogen of asparagine via N-acetylglucosamine, as one of the post-translational modifications. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13465] "It refers to amino acid residue within a peptide that accepts covalent linkage of fatty acid, myristoyl group (C13H27-) as one of the co-translational modifications. N-myristoylation, catalyzed by N-myristoyltransferase, is the amide modification of proteins by the addition of a myristoyl group to an N-terminal glycine residue. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13466] "It refers to amino acid residue within a peptide that accepts fatty acid, palmitoyl group (C15H31-)as one of the reversible post-translational modifications. Protein palmitoylation is a thioester bond between palmitoyl-CoA and cysteine thiol. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13467] "Generally refers to amino acids residues that were covalently modified by phosphate group (PO4-). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13468] "YDYVHL (tyrosine-aspartic acid-tyrosine-valine-histidine-leucine) is a preferred substrate sequence by focal adhesion kinase.  The phosphorylated YDYVHL containing protein recruits src family kinases, which can then phosphorylate other tyrosine residues within the peptide. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13469] "It refers to amino acid tyrosine residue that was covalently modified by phosphate group (PO4-). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[13470] "It refers to amino acid serine residue that was covalently modified by phosphate group (PO4-). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13471] "It refers to amino acid threonine residue that was covalently modified by phosphate group (PO4-). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13472] "Typically found in SH2-Binding Motifs of signaling proteins, the YXXP Motif interacts with SH2 domains of partner proteins upon Y phosphorylation. SH2 domains of ~100 amino acids bind to specific phosphotyrosine (pY)-containing motifs with dissociation constants of ~50-500 nM. A conserved pocket of SH2 domains recognizes the pY; a more variable pocket binds residues C-terminal to pY that confer specificity. SH2 domains balance high affinity for pY and recognition of adjacent residues to allow specific discrimination. The SH2 domain, an anti-parallel b-sheet between a-helices, provides a positively charged b-sheet pocket for binding of pY moieties, and an extended b-sheet surface for binding residues C-terminal to pY. B-sheet surface differences have significant effects on ligand-specificity. (NCI)"                                                                                                                                                           
[13473] "It refers to amino acid residues that can be the target for protein kinase C phosphorylation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13474] "The amphipathic helix motif is characterized by a repeating pattern of polar (P) and non-polar (N) sidechains that can be summarized as PxNPPNx. These clusters varied in length from 6 to 15 residues. The conserved non-polar positions are marked by a distinct absence of Asp, Asn and Ser, while other polar sidechains are sometimes allowed. (from http://isites.bio.rpi.edu/bystrc/Isites/amph_alpha.html)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13475] "It refers to the covalent bond between 2 sulfide atoms from the thiol group of 2 cysteine residues (S-S). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13476] "A protein region consisting of a hydrophilic surface and a hydrophobic core."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13477] "Tertiary structure describes the folding of the polypeptide chain to assemble the different secondary structure elements in a particular arrangement. As helices and sheets are units of secondary structure, so the domain is the unit of tertiary structure. In multi-domain proteins, tertiary structure includes the arrangement of domains relative to each other as well as that of the chain within each domain. (from expasy.org)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13478] "An informal header for somewhat informal parts of a protein molecule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13479] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13480] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13481] "Any portion of a protein molecule with a net negative charge."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13482] "The Cysteine-Rich Domain is usually found in two copies per protein. It contains up to four conserved cysteines. The family includes a subunit from heterodisulfide reductase and a subunit from glycolate oxidase and glycerol-3-phosphate dehydrogenase. (Pfam PF02754)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13483] "Any of the lipid bilayer membranes within a cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13484] "The Gly-rich NAD-Binding Domain (often N-terminal) is often found in metabolic enzymes involved in glycolysis, glyconeogenesis, and the citric acid cycle, such as GAPDH (glyceraldehyde-3-phosphate oxidation and phosphorylation), lactate dehydrogenases (lactate to pyruvate conversion), and malate dehydrogenases (malate to oxaloacetate interconversion). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13485] "The GXGXXXG Motif is often found it the NAD-binding domain (often N-terminal) in metabolic enzymes involved in glycolysis, glyconeogenesis, and the citric acid cycle, such as GAPDH (glyceraldehyde-3-phosphate oxidation and phosphorylation), lactate dehydrogenases (lactate to pyruvate conversion), and malate dehydrogenases (malate to oxaloacetate interconversion). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13486] "A Substrate Domain is a protein region that physically interacts stereospecifically, and usually at high affinity, with a specific target substrate. In enzymes, the substrate domain is often, though not necessarily, coincident with the catalytic domain. Typically, substrate interaction results in some protein conformational alteration and functional modification. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13487] "The AAA proteins (ATPases Associated with a variety of cellular Activities) are found in eubacterial, archaebacterial, and eukaryotic species and participate in many cellular processes, including protein degradation, vesicle fusion, cell cycle control, and cellular secretory processes. They are characterized by the presence of a 230 to 250-amino acid ATPase domain referred to as the Conserved ATPase Domain (CAD). AAA CADs of 133 CAD sequences from 38 species are organized into discrete groups that are related not only in structure but in cellular function. CAD-containing proteins in the eukaryotic lineages seem to have diversified by a series of gene duplication events that lead to the establishment of different functional AAA proteins, including proteasomal regulatory, NSF/Sec, and Pas proteins. The phylogeny of the CADs provides the basis for establishing the patterns of evolutionary change that characterize the AAA proteins. (From PubMed 9342402)"
[13488] "Eukaryotic protein kinases are enzymes belonging to a very extensive family of proteins which share a conserved catalytic core common with protein kinases. There are a number of conserved regions in the catalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is a glycine-rich stretch of residues in the vicinity of a lysine residue, which has been shown to be involved in ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residue which is important for the catalytic activity of the enzyme. Tyrosine kinase receptors are a family of receptors with a similar structure. They each have a tyrosine kinase domain (which phosphorylates proteins on tyrosine residues), a hormone binding domain, and a carboxyl terminal segment with multiple tyrosines for autophosphorylation. (From InterPro IPR000719, http://faculty.plattsburgh.edu/donald.slish/tyrosinekinase/TK1.html)"                 
[13489] "The Dbl homology (DH) or RhoGEF domain consists of a 150 amino acid region that induces Rho family GTPases to displace GDP. This effectively activates the Rho GTPase by allowing binding to GTP, which is in excess over GDP in the cell. The DH domain is invariably proceeded by a pleckstrin homology (PH) domain. While not absolutely required for catalysis of nucleotide exchange, the PH domain appears to greatly increase catalytic efficiency in many cases. Rho proteins control actin dynamics, gene expression, membrane trafficking, growth factor signaling, and cellular transformation. Proteins encoding DH domains (RhoGEFs) also play a role in these events as they function as the primary activators of Rho GTPases. In fact, many RhoGEFs were identified based on their transforming activity, which was abrogated upon disruption of their DH domain. (Pawson Lab, SLRI, Mount Sinai Hospital, 2003)"                                                                   
[13490] "PH domains are protein modules of approximately 120 amino acids found in a wide variety of signalling proteins in organisms ranging for yeast to humans. Some PH domains bind with high affinity (low mM or nM Kd) to specific phosphoinositides such as phosphatidyl-inositol (PI) -4,5-bisphosphate, PI-3,4-P2 or PI-3,4,5-P3. Binding to phosphoinositides may allow PH proteins to respond to lipid messengers for example by relocation to membranes. The C-termini of some PH domains have also been reported to bind the beta/lambda subunits of heterotrimeric G proteins.(www.mshri.on.ca/pawson)"                                                                                                                                                                                                                                                                                                                                                                                         
[13491] "The REM repeat, which is also called rho effector or HR1 domain, was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN). The first two of these repeats were later shown to bind the small G protein rho known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal REM repeat complexed with RhoA has been determined by X-ray crystallography. It forms an antiparallel coiled-coil fold termed an ACC finger. (pfam.wustl.edu/cgi-bin/getdesc?name=HR1)"                                                                                                                                                                                                                                                                                                 
[13492] "A DNA-binding domain binds to a specific DNA sequence and a transcriptional activation domain interacts with the basal transcriptional machinery. An association of a transcriptional activation domain with a DNA-binding domain promotes the assembly of RNA polymerase II complexes at the TATA box and increase transcription. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13493] "The cysteine-rich N-terminal DAG/PE (Diacylglycerol/Phorbol Ester)-Binding (C1) Domain of PKC isoforms interacts with phorbol ester or with the phospholipid-derived second messenger diacylglycerol. C1 contains one or two copies of a Cys-rich domain about 50 amino-acid residues long; the domain binds two zinc ions, probably involving the conserved cysteines and histidines. Bound to DAG, C1 domains are involved in recruitment of proteins to the membrane via basic residues that interact with lipid head groups. Part of the domain contains two beta sheets that form a cavity and a short C-terminal alpha helix; another contains two zinc-binding sites that maintain the domain fold. Binding of diacylglycerol, or phorbol ester, to the domain results in modification of protein function. (NCI)"                                                                                                                                                                           
[13494] "The Estrogen Binding Domain is an all-helical ligand-binding domain within its nuclear hormone receptor. Steroid hormones, such as estrogen, and their receptors regulate eukaryotic gene expression, affecting target cell proliferation and differentiation. Hormone-receptor complexes recognize discrete DNA sequences upstream of transcription start sites. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13495] "Associated with binding and hydrolysis of GTP, the highly conserved GTP-Binding Domain is typically found in signaling RAS-related proteins of the small GTPase superfamily. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13496] "The polymeric immunoglobulin receptor is a model system to study protein traffic in epithelial cells. This receptor travels first to the basolateral surface where it can bind polymeric IgA or IgM. The receptor is then endocytosed and delivered to endosomes. The receptor is sorted into transcytotic vesicles which are exocytosed at the apical surface. The 103 amino acid cytoplasmic domain of the receptor contains several sorting signals. The 17 residues closest to the membrane are an autonomous signal for basolateral sorting. For endocytosis there are two signals, both of which contain tyrosines. Finally, transcytosis is signaled by serine phosphorylation. (From PubMed PMID1813030 and NCI)"                                                                                                                                                                                                                                                                           
[13497] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13498] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13499] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13500] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13501] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13502] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13503] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13504] "RNA Binding Domains, such as the RRM, RGG box, and KH domain, mediate the interaction of RNAs with RNA-binding proteins. RRMs of about 90 amino acids consist of a four-stranded beta sheet adjacent to two alpha helixes. Within RRMs, conserved RNP-1 and RNP-2 motifs on the central beta sheets lie side by side; their side chains contact RNA. Found in hnRNP proteins, the RGG box is an RNA-binding motif containing five Arg-Gly-Gly repeats with intervening aromatic residues. The KH domain is found in several RNA-binding proteins in multiple repeats interspersed with RGG boxes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                            
[13505] "First identified in human hnRNPK protein, the conserved KH Domain of around 45-70 amino acids is present in a variety of nucleic acid-binding proteins. The domain may bind RNA in vivo. KH motifs are found in one or multiple copies, interspersed with RGG repeats, that may function cooperatively or, in single motif proteins, independently. KH domains can be separated into two groups: type-1 (beta-alpha-alpha-beta-beta-alpha) and type-2 (alpha-beta-beta-alpha-alpha-beta). The VIGXXGXXI sequence is preserved in the RNA binding motif between helix 1 and 2 (type-1) and helix 2 and 3 (type-2). The beta sheets are supported by alpha helixes. (NCI)"                                                                                                                                                                                                                                                                                                                            
[13506] "SET domains appear to be protein-protein interaction domains. SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The SET domain genes are widely represented in the eukaryotic genomes. Proteins bearing the widely distributed SET domain (ca. 130 amino acid) contribute to epigenetic mechanisms of gene regulation by methylation of lysine residues in histones and other proteins. The SET domain appears generally as one part of a larger multidomain protein. It appears that the varied domains that occur together with the SET domain are involved in recognizing protein substrates and ''reading'' histone tails in order to dictate which (if any) of their multiple lysine residues should get methylated. (From Pfam PF00856)"                                                                                                                                                                     
[13507] "The approximately 100-amino acid ARID (AT-Rich Interaction Domain) DNA-binding domain occurs in some transcriptional regulators (and perhaps modifiers of chromatin structure) involved in embryonic development, cell lineage, and cell cycle control. The domain shows more diversity in structure and function than the highly conserved sequence suggests: at least six alpha helices separated by beta-strands, loops, or turns. Although Bright, dead ringer, and MRF-2 preferentially bind to AT-rich sites, DNA binding of ARID-proteins is not necessarily sequence specific; ARID protein p270 of the SWI-SNF complex exhibits non-specific DNA binding activity. ARID family proteins may be involved in a wide range of DNA interactions. Inappropriate expression of ARID proteins is increasingly implicated in tumorigenesis. (NCI)"                                                                                                                                                 
[13508] "The BTB/POZ domain is an approximately 120 amino acid long, hydrophobic region found in two distinct classes of transcriptional regulators that contain either a C-terminal basic leucine zipper motif (POK proteins) or a Zn-finger region (Bach proteins).  This domain has been shown to form homo-dimers in a number of BTB/POZ domain containing proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13509] "The Zinc Finger Domain is found in many proteins that bind nucleic acids, typically DNA binding transcription factors. There are several classes of Zn finger proteins. Some bind Zn with only Cys residues (e.g., nuclear receptor superfamily) while others coordinate Zn with Cys and His residues. In the 25-amino acid C2H2 type motif, Zn2+ is held between a pair of anti-parallel beta strands and a single alpha helix by a pair of invariant Cys and His residues. The Cys/His type proteins generally contain repeated units and bind DNA as a monomer, while Cys/Cys proteins contain two units that bind inverted DNA repeats as homo- or heteodimers. In some Cys/Cys types the Zn ion folds the involved region into a globular structure that binds DNA. (NCI)"                                                                                                                                                                                                                     
[13510] "Zinc finger domains are thought to be involved in DNA-binding. Different types exist depending on the cysteine residue positions. C-X8-C-X5-C-X3-H type zinc finger proteins often function in cell cycle or growth regulation, e.g. human TIS11B (butyrate response factor 1) and mouse TTP nuclear protein. The splicing factor U2AF 35-kD subunit, which mediates protein-protein and protein-RNA interactions required for 3-prime splice site selection, also contains this domain. Different CCCH zinc finger proteins interact with the 3-prime UTR of various mRNA. This type of zinc finger is often present in two copies. (NCI)"                                                                                                                                                                                                                                                                                                                                                         
[13511] "A C4HC3 zinc-finger-like motif, the PHD finger is found in nuclear proteins thought involved in chromatin-mediated transcriptional regulation. Single or multiple fingers are found. A specific function is not yet known, but it could be involved in protein-protein interactions important for assembly/activity of multi-component transcriptional regulatory complexes. In CBP it is an integral part of the acetyltransferase enzymatic core domain and contributes to CBP transcriptional activity. PHD fingers fold into an interleaved Zn-finger chelating two Zn ions in an atypical cross-braced conformation also shared by the FYVE and RING fingers; the zinc sites are located at opposite ends of a beta-sheet. Surrounding loops vary significantly in length and sequence between these three domains. (NCI)"                                                                                                                                                                     
[13512] "In transcription regulators of cell cycle control, cell determination, and cell differentiation, the conserved HLH (Helix-Loop-Helix) Domain of 40-50 amino acids forms amphipathic helixes between a variable loop. HLHs typically mediate homo- or heterodimerization through interactions with self or other motifs to activate or inactivate trans-activating function. The N-helix often contains DNA-interacting basic residues; the C-helix typically contains characteristically spaced hydrophobic residues. An adjacent basic region of 15 amino acids in most HLH proteins binds to DNA. Basic (b)HLH proteins bind variants of the 'CANNTG' E-box. Proteins lacking the basic domain act as inhibitors, failing to bind DNA. bHLH proteins exhibit specific dimerization partner combinations. In calcium-binding proteins, certain invariant hydrophilic loop residues in the HLH motif bind calcium. (NCI)"                                                                           
[13513] "Ankyrin Repeats are tandem modules of about 33 amino acids. The conserved domain structure has been described as side-by-side anti-parallel alpha helices connected by intervening beta hairpin motifs or as beta, alpha, alpha, beta secondary structures or as an L-shaped beta-hairpin and two alpha-helices. The repeats associate to form a higher order structure. Despite sequence variation, the domain core maintains a stable surface of contact residues to mediate protein-protein interactions. Target protein binding involves contacts by the beta hairpin tips and the helical bundle surface facing the Ankyrin groove. ANK repeats have been identified in over 1700 functionally diverse proteins, primarily from eukaryotes; no common theme among the protein targets has been identified. The Ankyrin cytoskeletal protein is composed almost entirely of these repeats. (NCI)"                                                                                               
[13514] "Identified in over 240 functionally diverse proteins from yeast to man, ARM Repeats are approximately 40-amino acids long and composed of two longer anti-parallel helices (H2 and H3) that follow a perpendicular short helix (H1). Tandem repeats form a right-handed superhelix (3 helixes per unit); tight repeat packing creates a cylindrical hydrophobic core throughout the structure. Lined by highly conserved residues, the positively charged groove of the superhelix appears to mediate interaction with acidic surfaces of target proteins. Despite amino acid variability, ARM repeat structures are highly conserved. Though involved in protein-protein interactions, no common features among target proteins have been identified. ARM repeats have a common phylogenetic origin with the HEAT repeat; both contain seven highly conserved hydrophobic residues. (NCI)"                                                                                                         
[13515] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13516] "The F-box consists of three helices. The H1 helix packs orthogonally with the H2-H3 antiparallel pair. The F-box domain is a 42-48 amino acid conserved domain found at the N-terminus of F-box proteins. F-box proteins act as adaptor components of the modular E3 ubiquitin ligase SCF complex that functions in phosphorylation mediated ubiquitination. The F-box domain mediates interaction with Skp1, which links F-box proteins to a core ubiquitin-ligase complex composed of Rbx1, cdc53/Cul1 and the E2 conjugating enzyme cdc34. The C-terminal region of F-box proteins are also composed of various modular domain that interact with target substrates, often in a phosphorylation dependant manner.(www.mshri.on.ca/pawson)"                                                                                                                                                                                                                                                       
[13517] "The GSK-Binding Domain of AXIN2 mediates interaction with GSK3-Beta. Involved in regulation of the WNT signaling pathway, AXIN2 organizes an APC/Beta-Catenin/GSK3-Beta/ AXIN2 complex that leads to Beta-Catenin degradation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13518] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13519] "Proline-Rich Domains may be involved in heterotypic protein-protein interactions in signal transduction or other pathways. Found in signaling and structural proteins, WW domains are composed of approximately 40 amino acids folded as a stable, triple stranded beta-sheet that recognize proline-rich sequences. Some WW domains show a remarkable similarity to SH3 domains, which also appear to recognize some proline-rich sequences. Ena/VASP (Drosophila Enabled/Vasodilator-Stimulated Phosphoprotein) Family members regulate actin filament assembly, often through association with binding partners that display a proline-rich FPPPP motif. Ena/VASP proteins interact with these partners via the highly conserved Ena/VASP homology 1 (EVH1) domain. (NCI)"                                                                                                                                                                                                                       
[13520] "Typically 120 amino acids long, the RGS (Regulator of G protein Signaling) Domain is found in over 20 human proteins, bind activated G-alpha subunits, and are responsible for GAP function. Through other domains (e.g., DEP, PDZ, or PH) RGS proteins link to other signaling molecules. RGS domains contain conserved contiguous, or dispersed, GH subdomains (GH1, 2, and 3). All RGS domains share a tertiary structure of nine alpha helixes that form a right-handed anti-parallel bundle of helixes 4-7 and a terminal bundle of helixes 1-3 and 8-9. The 3-4, 5-6, and 7-8 helix loops form an interaction surface between RGS4 and Ga(i). RGS domains allosterically stabilize the G-alpha GTP binding pocket, accelerating GTPase activity. Thus, RGS Family members rapidly inactivate G protein signal transmission from seven transmembrane receptors in GPCR signaling pathways. (NCI)"                                                                                              
[13521] "Typically found in signaling proteins, the SH2-Binding Motif mediates regulated high-affinity physical interaction (binding) with the target SH2 (SRC Homology 2) domain. SH2 domains of ~100 amino acids bind to specific phosphotyrosine (pY)-containing motifs with dissociation constants of ~50-500 nM. A conserved pocket of SH2 domains recognizes the pY, and a more variable pocket binds residues C-terminal to pY that confer specificity. SH2 domains balance high affinity for pY and recognition of adjacent residues to allow specific discrimination. The SH2 domain, an anti-parallel b-sheet between a-helices, provides a positively charged b-sheet pocket for binding of pY moieties, and an extended b-sheet surface for binding residues C-terminal to pY. B-sheet surface differences have significant effects on ligand-specificity. (NCI)"                                                                                                                                
[13522] "Typically found in proteins involved in signaling pathways, the SH3-Binding Motif is a peptide sequence that mediates regulated high-affinity physical interaction (binding) with the SH3 (SRC Homology 3) domain in target protein partners. The SH3-binding motif often share proline-rich stretches containing a common PXXP motif. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13523] "The SH3 domain, often seen in signaling pathway proteins, frequently binds to a conserved PXXP Motif usually found in proline-rich regions of target proteins. The SH3 domain contains a site located between the RT and n-SRC loops that binds the PXXP motif, which then adopts a poly-proline type II (PPII) conformation. PXXP motifs are often clustered and have residues that contribute to binding specificity. Class I motifs have an amino to carboxy terminal binding orientation and include sites specific for the SRC oncoprotein. More promiscuous in their binding, Class II motifs have a carboxy to amino terminal binding orientation, PXXP can be in either of two positions, and they have basic residues at the C-terminus. (NCI)"                                                                                                                                                                                                                                            
[13524] "WD40 Repeats are found in signal transduction, mRNA processing, cytoskeletal assembly, and cell cycle proteins; none are catalytic. G-beta is the prototypic WD40 protein. WD-40 proteins contain 5-8 repeats of about 40 residues, with a central Trp-Asp (WD) motif. The repeats may span the entire protein or make up either terminal or the central section. WD40 domains serve as a platform to which proteins stably or reversibly bind; some may recognize phosphoSer and -Thr peptides. The repeat forms a closed ring propeller with seven blades each composed of a four-stranded anti-parallel b-sheet. Each repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal repeat completes the blade of the first repeat. Residues on the propeller top surface likely coordinate interactions with other proteins or ligands. (NCI)"                                                                                                   
[13525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13526] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13527] "Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residues are denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand). (From InterPro IPR002048)"                                                                                                                                                                                                                                                                                                                                                                          
[13528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13529] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13531] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13534] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13535] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13536] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13537] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13538] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13539] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13540] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13541] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13542] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13543] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13544] "The UBA-domain is a sequence motif found in multiple enzyme classes having connections to ubiquitin and the ubiquitination pathway, including human ubiquitin isopeptidase T and several other ubiquitin C-terminal hydrolases catalyzing regulatory protein-deubiquitination. Mammalian proto-oncogene c-cbl is a protein interacting with multiple signal transduction factors. Cbl has recently been shown to undergo regulatory ubiquination upon macrophage stimulation. (From http://www.isrec.isb-sib.ch/domains/uba/index.html)"                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13545] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13546] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13547] "The location of the atoms, groups or ions relative to one another in a molecule, as well as the number and location of chemical bonds."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[13548] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13549] "Any structures that are not enclosed intracellularly are considered extracellular structure, including structures on the cell surface. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13550] "A quickly growing cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13551] "Having a weakened immune system caused by certain diseases or treatments."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13552] "Having an abrupt onset of symptoms and a short course; not chronic."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13553] "A disease or condition that persists or progresses over a long period of time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13554] "(en-KAP-soo-lay-ted) Confined to a specific, localized area and surrounded by a thin layer of tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13555] "(ma-LIG-nant) Cancerous; a growth with a tendency to invade and destroy nearby tissue and spread to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13556] "(an-ah-PLAS-tik) A term used to describe cancer cells that divide rapidly and have little or no resemblance to normal cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13557] "(IN-doe-lint) A type of cancer that grows slowly."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13558] "Restricted to the site of origin, without evidence of spread."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13559] "Having to do with skin cancer that develops in basal cells or squamous cells but not in melanocytes (pigment-producing cells of the skin)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13560] "Cancer that has not spread from the primary (original) site to other sites in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13561] "Causing the breakdown of bone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13562] "Taken from an individual's own tumor tissue; may be used in the development of a vaccine that enhances the body's ability to build an immune response to the tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13563] "Unable to be removed with surgery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13564] "Originating in the blood or spread through the bloodstream."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[13565] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13566] "Of or relating to the alveoli."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13567] "Pertaining to apoptosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13568] "straddling the dividing line between two categories."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13569] "denoting fast growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13570] "marked by a tendency to spread especially into healthy tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13571] "in the natural or normal place, confined to the site of origin without invasion of neighboring tissues. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13572] "denoting slow growth; indolent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13573] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13574] "(MYOO-sin-us) Containing or resembling mucin, the main compound in mucus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13575] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13576] "Being approximately average or within certain limits; conforming with or constituting a norm or standard or level or type or social norm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13577] "of or relating to or resembling papilla."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13578] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13579] "(SEER-us) Having to do with serum, the clear liquid part of blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13580] "shaped like a tube; of or pertaining to a tubule. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13581] "abounding in, or covered with, fine hairs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13582] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13583] "(beh-NINE) A noncancerous growth that does not invade nearby tissue or spread to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13584] "occurring again."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13585] "(MET-uh-STAT-ik) Having to do with metastasis, which is the spread of cancer from one part of the body to another."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13586] "Widely spread; not localized or confined."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13587] "A term used to describe cells or tissues that do not have specialized (\"mature\") structures or functions. Undifferentiated cancer cells often grow and spread quickly."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13588] "A group of DNA containing viruses which cause respiratory disease, including one form of the common cold."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13589] "cold blooded chordates; larva are usually aquatic, breathing by gills; adults are terrestrial or aquatic, breathing by lungs and through moist glandular skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13590] "An animal pathogen that is a virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13591] "A living, sentient organism that has membranous cell walls, requires oxygen and organic foods, and is capable of voluntary movement, as distinguished from a plant or mineral."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13592] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13593] "Experimental organism whose genome has been altered by the transfer of a gene or genes from another species or breed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13594] "Any of several small, burrowing, chiefly nocturnal mammals with body covered with strong horny plates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[13595] "A genus of the family RETROVIRIDAE with type C morphology, that causes malignant and other diseases in wild birds and domestic fowl. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13596] "A large group of single-cell microorganisms.  Some cause infections and disease in animals and humans.  The singular of bacteria is bacterium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13597] "A virus that infects and lyses certain bacteria."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13598] "warmblooded oviparous tetrapods with feathers, one occipital condyle, forelimb modified into wings, heart with 2 ventricles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13599] "causes papillomas on the head and neck and in the mouth and esophagus; injection into hamsters and mice produces fibrosarcomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13600] "The domestic cat Felis catus"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13601] "Domesticated ungulates that are raised for beef, dairy products, and leather, and used for labor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13602] "The common domestic fowl, Gallus gallus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13603] "An individual whose body contains cell populations derived from different zygotes. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13604] "A species of the fungus Cryptococcus, which causes cryptococcosis. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13605] "A virus that may be carried in an inactive state for life by healthy individuals.  It is a cause of severe pneumonia in people with a suppressed immune system, such as those undergoing bone marrow transplantation or those with leukemia or lymphoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13606] "A two-winged insect in the order Diptera. Typical used to refer to Drosophila melanogaster, the fruit fly; the subject of classical genetic studies, because of its rapid generation time and easily observed characteristics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13607] "An invertebrate animal (e.g., tick, mite, mosquito, bloodsucking fly) capable of transmitting an infectious agent among vertebrates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13608] "DNA viruses producing malignant tumors. Of the six major groupings of DNA viruses four contain members which are actually or potentially oncogenic: the Adenoviridae, the Herpesviridae, the Papovaviridae, and the Poxviridae. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13609] "A DNA virus is a virus that has DNA as its genetic material and does not use an RNA intermediate during replication."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13610] "The domestic dog Canis familiaris"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13611] "A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13612] "A (+) strand single strand RNA virus of the picornavirus family.  Poliovirus is an enterovirus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13613] "A common virus that remains dormant in most people. It has been associated with certain cancers, including Burkitt's lymphoma, immunoblastic lymphoma, and nasopharyngeal carcinoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13614] "Equine Infectious Anemia Virus, a lentivirus related to HIV (DCB-BC)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13615] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13616] "A vertebrate animal usually having fins and a covering of scales or plates. It breathes by means of gills, and lives almost entirely in the water. (from Webster, 1913)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13617] "A family of enveloped viruses with a genome consisting of a single molecule of linear positive-sense single-stranded RNA. They infect molluscs, mammals, and birds and are transmitted by arthropod vectors.  The family includes the hepatitis C and hepatitis G viruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13618] "A kingdom of eukaryotic, heterotrophic organisms that live as saprobes or parasites, including mushrooms, yeasts, smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi refer to those that grow as multicellular colonies (mushrooms and molds)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13619] "Any of various hollow-horned, bearded ruminant mammals of the genus Capra, originally of mountainous areas of the Old World, especially any of the domesticated forms of C. hircus, raised for wool, milk, and meat. (from American Heritage Dictionary on line)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13620] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13621] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13622] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13623] "The Hepadnavirus Family derives its name from its hepatotropic nature and double-stranded DNA genome. The hepadnaviral genome is unique in that the plus strand is incomplete, leaving 15-50% of the molecule single-stranded and the minus strand while being complete, possesses a discontinuity at a unique site. The hepatitis B virus (HBV) is the only causative agent for a human disease within the family. (http://www.stanford.edu/group/virus/hepadna/2000/hepadnavirus.html)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13624] "A virus that causes hepatitis (inflammation of the liver). It is carried and passed to others through blood or sexual contact. Also, infants born to infected mothers may become infected with the virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13625] "Any of the viruses that cause inflammation of the liver. They include both DNA and RNA viruses as well viruses from humans and animals. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13626] "(HER-peez VYE-rus) A member of the herpes family of viruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13627] "Human herpesvirus 6. Subset of SIC 39 (Herpes virus). Possible factor in etiology of chronic fatigue syndrome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13628] "HIV.  The cause of acquired immunodeficiency syndrome (AIDS)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13629] "The type species of LENTIVIRUS and widely recognized as the etiologic agent of acquired immunodeficiency syndrome (AIDS). It is characterized by its cytopathic effect and affinity for the T4-lymphocyte. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13630] "An HIV species related to HIV-1 but carrying different antigenic components and with differing nucleic acid composition. It shares serologic reactivity and sequence homology with the simian Lentivirus SIV and infects only T4-lymphocytes expressing the CD4 phenotypic marker."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13631] "Equus caballus"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13632] "A retrovirus that infects T-cells (a type of white blood cell) and can cause leukemia and lymphoma.  HTLV-1 is spread by sharing syringes or needles used to inject drugs, through sexual contact, and from mother to child at birth or through breast-feeding."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13633] "RAEB: Human T-cell Leukemia Virus - II.  A species of HTLV-BLV VIRUSES that can transform normal T-lymphocytes and can replicate in both T- and B-cell lines. The virus is related to but distinct from HTLV-I. It is associated with T-cell hairy cell leukemia, a relatively benign disease. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[13634] "Belonging to man or mankind; pertaining to man or to the race of man; use of man as experimental subject or unit of analysis in research"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13635] "(pap-ih-LO-ma-VYE-rus) HPV. A virus that causes abnormal tissue growth (warts) and is often associated with some types of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13636] "have 3 pairs of legs, 3 body regions, 1 pair of antennae, and often 1-2 pairs of wings; 26 Orders, 703,500 known species."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13637] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13638] "A species of POLYOMAVIRUS, originally isolated from the brain of a patient with progressive multifocal leukoencephalopathy. The patient's initials J.C. gave the virus its name. Infection is not accompanied by any apparent illness but serious demyelinating disease can appear later, probably following reactivation of latent virus. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13639] "etiologic agent of lymphocytic choriomeningitis; occurs naturally in mice, dogs and monkeys."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13640] "Any of several species of short-tailed monkeys of the genus Macacus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13641] "A macaque, Macaca fascicularis or M. cynomolgus, found mostly in southeastern Asia, Borneo, and the Philippines."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13642] "A pale brown Asian macaque (Macaca mulatta) often used in medical research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[13643] "Any warm-blooded vertebrate having the skin more or less covered with hair; young are born alive except for the small subclass of monotremes and nourished with milk."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13644] "Type B retrovirus.  Etiologic agent of mouse mammary tumors.  Transmitted horizontally through the lactating mammary gland and vertically through the germline.  Mechanism of tumorigenesis involves the activation of cellular int genes by promoter/enhancer insertion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13645] "Mason-Pfizer Monkey Virus; causes AIDS-like disease (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13646] "The type species of MORBILLIVIRUS and the cause of the highly infectious human disease measles, which affects mostly children.  (MSH99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13647] "Any of numerous species of small rodents belonging to the genus Mus and various related genera of the family Muridae."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13648] "A type of laboratory mouse that is hairless, lacks a normal thymus gland, and has a defective immune system because of a genetic mutation.  Athymic, nude mice are often used in cancer research because they do not reject tumor cells, from mice or other species."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13649] "Laboratory mice that have been produced from a genetically manipulated egg or embryo. The technique involves microinjection of foreign DNA fragments into the nucleus of the fertilized egg and transferring it into the uterus of a foster mother mouse. The inserted gene becomes integrated into every cell and tissue of the developing mouse, including its germ line cells. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13650] "A murine virus arising during the propagation of S37 mouse sarcoma, and causing lymphoid leukemia in mice. It also infects rats and newborn hamsters and is apparently transmitted vertically to embryos in utero and through mother's milk. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13651] "A replication-defective murine sarcoma virus (SARCOMA VIRUSES, MURINE) isolated from a rhabdomyosarcoma by Moloney in 1966. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13652] "Any haplorhine primate not belonging to the family Tarsiidae, Hylobatidae, Pongidae, or Hominidae; this does not correspond to any taxon. This group is divided into Old World monkeys (Cercopithecidae) and New World monkeys (Callitrichidae and Cebidae).  Many types are used as an experimental model for human disease and drug testing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13653] "Type C retroviruses that cause leukemia in mice.  Includes the Abelson, AKR, Friend, Moloney, Gross, and other leukemia viruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13654] "The type species of RUBULAVIRUS that causes an acute infectious disease in humans, affecting mainly children. Transmission occurs by droplet infection.  (MSH99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13655] "Taxonomic family which includes mice and rats."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13656] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13657] "Nematodes are soil-inhabiting roundworms of the Phylum Nematoda."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13658] "Viruses that produce tumors. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13659] "A living thing, such as an animal, a plant, a bacterium, or a fungus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13660] "cause proliferation of epithelium of skin or mucous membranes; usually are host specific; have been isolated from humans, cattle, deer, dogs, goats, horses, rats, and sheep."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13661] "Large terrestrial monkey found in Africa and Arabia; the largest non-Hominid member of the primate order. They have long dog-like muzzles, close-set eyes, heavy powerful jaws, thick fur except on their muzzle, short tail and often brightly coloured ischial callosities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13662] "RAEB: Papovaviridae. A family of small, antigenically distinct viruses that replicate in nuclei of infected cells; most have oncogenic properties. Virions are 45 to 55 nm in diameter, nonenveloped, and ether-resistant; capsids are icosahedral with 72 capsomeres, and they contain double-stranded DNA (MW 3 to 5 106). The family includes the genera Papillomavirus and Polyomavirus. Includes papilloma, polyoma, and vacuolating viruses; the most commonly encountered of the last category is SV40."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13663] "The type species of Paramyxovirus. Causes laryngotracheitis in humans, especially children. Also called hemadsorption virus 2 (HA2). (MSH99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13664] "A family of negative-strand single-strand RNA viruses which includes Mumps and Measles viruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13665] "(+)-sense ssRNA viruses; have no envelope or core, nor any surface projections; replication is in the cytoplasm and is via two distinct partially double-stranded replicative intermediates; most of host range is species specific."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13666] "viruses that replicate in and may produce diseases of higher plants; see RTs for specific organisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13667] "Multicellular, eukaryotic life forms of the kingdom Plantae. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alteration of haploid and diploid generations. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13668] "A member of the enterovirus genus of RNA viruses"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13669] "normally present in hosts as latent infections, potentially oncogenic; host DNA may become enclosed in virus capsids creating a 'pseudovirus'; isolated from man, mouse, rabbit, hamster and several species of monkey."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13670] "A family of double-stranded DNA viruses infecting mammals (including humans), birds and insects. There are two subfamilies: CHORDOPOXVIRINAE, poxviruses of vertebrates, and ENTOMOPOXVIRINAE, poxviruses of insects. (MSH99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13671] "The taxonomic order that includes man, monkeys, and lemurs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[13672] "Unicellular organisms lacking a nuclear membrane to compartmentalize the genetic material."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13673] "Any of the smaller species of the genus Lepus, especially the common European species (Lepus cuniculus), and the common American rabbit (L. sylvalica). A common research animal. (from DCB-CI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13674] "An amphibian in the order Anura, which includes the toads. The commonest frog genera are Rana (grass frogs) and Hyla (tree frogs)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13675] "The common name for the species Rattus norvegicus. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13676] "A virus that causes respiratory infections with cold-like symptoms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13677] "This family of viruses resembles the orthomyxoviruses in size and shape, but arestructurally more complex; they possess RNA-dependent DNA polymerases (reverse transcriptases). Virions are about 100 nm in diameter, enveloped, and contain two identical molecules of positive sense, single-stranded RNA of high molecular weight.  This RNA serves as a template for the synthesis of a complementary DNA, which may be integrated into the host DNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13678] "RAEB: virus whose genome consists of RNA"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13679] "Taxonomic group that includes mice, rats, guinea pigs, squirrels, beavers, and many others."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[13680] "A species of unicellular fungus used as a research subject and in baking and beer brewing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13681] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13682] "Any of various woolly, usually horned ruminant mammals related to the goat."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[13683] "Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). The genetic organization of SIV is virtually identical to HIV. SIV is 50% homologous in nucleotide sequence to HIV-1. SIV and HIV-2 exhibit close structural and immunologic properties and are 75% homologous. SIV does not cause immune deficiency in its natural host, the African green monkey, but does produce SAIDS in the rhesus macaque. Subgroups of SIV include SIV-1 and SIV-2. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                   
[13684] "Animals or humans raised in the absence of a particular disease-causing virus or other microorganism. Less frequently plants are cultivated pathogen-free."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13685] "Murine leukemia viruses that are replication-defective and rapidly transforming. The envelope gene plays an essential role in initiating erythroleukemia, manifested by splenic foci, splenomegaly, and polycythemia. Spleen focus-forming viruses are generated by recombination with other viral types including Friend P (polycythemia), Friend A (anemia), Rauscher, and Cas (from wild mice at Lake Casita, California). (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13686] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13687] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13688] "A species of POLYOMAVIRUS isolated from Rhesus monkey kidney tissue, which produces malignancy in human and newborn hamster kidney cell cultures and tumors on inoculation into newborn hamsters. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13689] "The domestic pig Sus scrofa domestica"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13690] "The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against smallpox. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of vaccinia virus. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13691] "Animals having a bony or cartilaginous skeleton with a segmented spinal column and a large brain enclosed in a skull or cranium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13692] "(VYE-rus) A microorganism that can infect cells and cause disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13693] "A woman is an adult, female human. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[13694] "An aquatic genus of the family Pipidae occurring in Africa and distinguished by having black horny claws on three inner hind toes.  Often used in reference to the African clawed \"frog\" (Xenopus laevis). (From MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13695] "Various unicellular fungi.  Saccharomyces cerevisiae and Schizosaccharomyces pombe are important research subjects.  Candida albicans is the usual etiological agent of vaginal yeast infections."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13696] "freshwater fish used in vertebrate genetic research and as a model for development."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13697] "A species of LENTIVIRUS, subgenus feline lentiviruses (LENTIVIRUSES, FELINE) isolated from cats with a chronic wasting syndrome, presumed to be immune deficiency. There is no antigenic relationship between FIV and HIV, nor does FIV grow in human T-cells. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[13698] "(HEEL-ih-ko-BAK-ter pye-LOR-ee) H. pylori. Bacteria that cause inflammation and ulcers in the stomach."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[13699] "RAEB: A genus of the family RETROVIRIDAE consisting of non-oncogenic retroviruses that produce multi-organ diseases characterized by long incubation periods and persistent infection. Lentiviruses are unique in that they contain open reading frames (ORFs) between the pol and env genes and in the 3' env region. Five serogroups are recognized, reflecting the mammalian hosts with which they are associated. HIV-1 is the type species. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13700] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13701] "contains several isolates of exogenous, horizontally transmitted and endogenous viruses of new and old world primates; associated with immunodeficiency diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13702] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13703] "Severe combined immunodeficient (SCID) mice like their human counterparts with immunodeficiency diseases are helpless not only to fight infection but also to reject transplanted tissue. These animals lack both T and B-cells and are used extensively in researches of immune disease or tissue transplantation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13704] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13705] "Helicobacter. A genus of gram-negative helical, curved, or straight microaerophilic bacteria with rounded ends and multiple sheathed flagella (unipolar or bipolar and lateral) with terminal bulbs. Form nonpigmented, translucent colonies, 1-2 mm in diameter. Catalase and oxidase positive. Found in gastric mucosa of primates, including human beings and ferrets. Some species are associated with gastric and peptic ulcers and gastric cancer. The type species is Helicobacter pylori."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13706] "One of two species of great apes; Pan troglodytes (the common chimpanzee) and Pan paniscus (the Bonobo, formerly called pygmy chimpanzee)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13707] "Generic category for HTLV-I and HTLV-II. ((NCI) RAEB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13708] "A family of very small DNA viruses containing a single linear molecule of single-stranded DNA and consisting of two subfamilies: PARVOVIRINAE and DENSOVIRINAE. They infect both vertebrates and invertebrates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13709] "produces fibrosarcomas in fowl, especially chickens; some strains may produce tumors in other animals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[13710] "temperate tailed phagae; does not integrate into host chromosome; prophage resembles plasmid and replicates autonomously at low numbers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13711] "tailed phage, isolated from E. coli."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13712] "A roundworm of the phylum Nematoda often utilized as a biological model system for research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13713] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13714] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13715] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13716] "The subfamily of Paramyxoviridae which includes Mumps and Measles viruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13717] "A subfamily of Paramyxoviridae which includes human respiratory syncitial virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13718] "A genus of Paramyxovirinae which includes Measles Virus"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13719] "A type of virus that has hemagglutinin-neuraminidase proteins in the outer coat and RNA as the genetic material.  Measles (rubeola) virus, mumps virus, and Newcastle disease virus are paramyxoviruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13720] "HSV is a nuclear replicating, icosahedral, enveloped DNA virus. The HSV envelope contains at least 8 glycoproteins. The matrix or tegument which contacts both the envelope and the capsid contains at least 15-20 proteins. There are two types of HSV - Type 1 and Type 2.  The Type 1 virus causes cold sores.  Most people get Type 1 infections during infancy or childhood. The Type 2 virus causes genital sores. Most people get Type 2 infections following sexual contact with an infected person."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13721] "an RNA virus which has been shown to be the major etiologic agent of non-A non-B hepatitis and causes substantial morbidity and mortality worldwide; also associated with cirrhosis and hepatocellular carcinoma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13722] "Taxonomic family which includes horses, zebras, and asses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13723] "Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to UV radiation tumorigenesis with single high-dose, but not chronic low-dose, exposures. SENCAR (SENsitive to CARcinogenesis) mice are used in research as an animal model for tumor production."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13724] "A poxvirus of the genus Avipoxvirus.  Has been adapted as a cloning vector (canarypox vector) for use as a mammalian expression vector."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13725] "Any organism, such as a pathogenic virus, parasite, or or bacterium, that is capable of invading body tissues, multiplying, and causing disease. (EPA Terminology Reference System)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13726] "Viruses which routinely infect humans"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13727] "A herpesvirus of sheep associated with pulmonary adenomatosis"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13728] "Genital warts caused by HPV 6 and 11 are the most common STD in the United States. Over a million cases are seen per year."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13729] "Animals which have a body temperature which is largely controlled by external factors of the environment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13730] "Taxonomic family which includes domestic and wild cats such as lions and tigers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13731] "Taxonomic family which includes the domestic pig"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13732] "Taxonomic family which includes domestic cattle, goats, and sheep."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13733] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13734] "A single stranded RNA virus.  A member of the picornaviridae family, subfamily hepatovirus.  The causative agent of Hepatitis A."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13735] "A genus of Paramyxovirinae which includes Mumps Virus"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13736] "RAEB: Species of an unnamed genus, subfamily GAMMAHERPESVIRINAE, isolated from patients with AIDS-related and \"classical\" Kaposi sarcoma. The sequences suggest this is a new human herpesvirus, unofficially identified as human herpesvirus-8 (HHV-8). (MSH99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13737] "B strain causes hepatitis in tamarins and possibly humans; putative etiological agent of GB hepatitis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[13738] "An organism that can be seen only through a microscope. Microorganisms include bacteria, protozoa, algae, and fungi. Although viruses are not considered living organisms, they are sometimes classified as microorganisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[13739] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13740] "Taxonomic family which includes the domestic dog, wolves and foxes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13741] "A type C avian retrovirus"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13742] "Any organism that lives in the sea"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13743] "Genetic elements propagated primarily through the germline, with a proviral structure, i.e. the chromosomally-integrated form of retroviruses and regulated by cellular processes.  Could be involved in development and serve as progenitors to pathogenic retroviruses.  Classified as ecotropic or xenotropic.  Ecotropic viruses can be transmitted to cells of the same species and can produce malignancies. Xenotropic viruses cannot infect cells from their host species but are infectious in heterologous species.  Cycles of transcription and reverse transcription make the elements mobile and mutagenic."                                                                                                                                                                                                                                                                                                                                                                           
[13744] "A plant which possesses a well-developed system of conducting tissue to transport water, mineral salts and sugars. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13745] "A type of Bovine Papilloma Virus"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13746] "Human papillomavirus-16 is the main causative organism of cervical cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13747] "Informal term for the generation of a mutant mouse in which the function of a particular gene has been completely eliminated, also called a null mouse."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13748] "A plant that does not have vascular tubes/tissues to transport food and water.  It belongs to the division Bryophyta, which includes liverwort, and moss."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13749] "An RNA containing virus infecting primates (SIV, STLV, SFV)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13750] "A murine leukemia virus (MuLV) variant cloned from rats infected with the Friend leukemia virus.  Neuropathogenic, causes hind limb paralysis in rats and mice, unlike the parent Friend virus which causes erythroleukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13751] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13752] "The Sloan-Kettering viruses (SKVs) are a group of transforming retroviruses that were isolated from chicken embryo cells which had been infected with the avian leukosis virus transformation-defective Bratislava 77 (tdB77). (from Li et al.  J Virol 1986;57:1065-72)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13753] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13754] "A single stranded RNA virus where the RNA strand is the complement of a mRNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13755] "Genus of the family RETROVIRIDAE consisting of exogenous horizontally-transmitted viruses found in a few groups of mammals. Infections caused by these viruses include human B or adult T-cell leukemia/lymphoma, and bovine leukemia. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13756] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13757] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13758] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13759] "A single stranded RNA virus where the RNA strand has the same polarity as a mRNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13760] "Strains derived by repeated backcrossing while maintaining one whole chromosome genetically different from the background strain. (JAX IMSR glossary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13761] "An individual cell or organisms which carries recombinant DNA"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13762] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13763] "Infectious agents, which while normally present but remaining benign under the control of the immune system, become virulent and pathogenic in immune-compromised hosts (i.e when they get the opportunity to become infectious)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13764] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13765] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13766] "Taxonomic family which includes rabbits and hares"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13767] "Terrestrial animals without back bones"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[13768] "Animals without a backbone that live in the ocean"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13769] "A species of spumavirus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13770] "A murine leukemia virus producing leukemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects DBA/2 and Swiss mice."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13771] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13772] "Herpes simplex infection on the genitals, most commonly herpes simplex-1 virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13773] "Congenic strains are produced by transferring a mutation from one genetic background to a specific inbred strain through repeated backcrossing. The congenic strain and the inbred partner are expected to be identical at all loci except for the transferred locus and a linked segment of chromosome. The size of the segment and the possibility of transferred alleles on other chromosomes depend on the number of backcross generations. A strain is considered fully congenic after ten generations of backcrossing (N10). (from JAX Strain Information)"                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13774] "A man is an adult, male human. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13775] "Virus integrated within host genome but inactive: may be reactivated by stress such as ultraviolet irradiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13776] "A virus which, as part of its life cycle, causes its host cells plasma membrane to rupture (to lyse)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13777] "A subjective term that might be applied to any non-human organism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13778] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13779] "An informal grouping of rna-containing viruses that are capable of inducing tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13780] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13781] "Strains of mice derived by repeated backcrossing while maintaining one whole chromosome genetically different from the background strain. (JAX IMSR glossary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13782] "Recombinant inbred (RI) strains are derived by systematic inbreeding from the cross of two pre-existing progenitor strains. (from JAX Strain Information)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13783] "HIV mutants which have overcome drug inhibition."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13784] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13785] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13786] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13787] "Mistletoe is the common name for various evergreen parasitic plants of the families Loranthaceae and Santalaceae (or Viscaceae), especially \"European mistletoe\" Viscum album and \"American mistletoe\" Phoradendron flavescens, with waxy white berries and smooth-edged oval leaves in pairs along the woody stem.  The extract is being studied for its potential use in cancer treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13788] "Anterior pituitary tumours nearly 100% in females over 18 months of age, pheochromocytomas or preneoplastic nodules in adrenal medulla about 40% in males, granulocytic leukaemia 14% in animals over 18 months of age. Rarely show hyperplastic cortical nodules or adrenal cortical adenomas. High incidence of severe chronic nephritis. (Snell 1967). High 10-week body weight in males (19/23), and high relative heart weight in 10-week old males (19/23) (Tanase et al 1982)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13789] "Less sensitive to the induction of mammary tumours by DMBA than two samples of outbred Sprague-Dawley rats; mean life-span 743-22 days."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13790] "Spontaneous thyroid carcinoma 33% (Lindsey et al 1968). Adrenal cortical tumours 94% and pituitary tumours 8-18% at 18 months (Hansen et al 1973). In animals over 18 months Snell found adenomas or carcinomas of adrenal cortex 73% in males and 95% in females, pituitary tumours 25%, granulosa cell tumours of the ovary 33% in females. High blood pressure (3/23), reaching 154+/-1.0 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Mammary tumours 26-30%. High incidence of retinal degeneration in animals over 10 months (von Sallman and Grimes 1972, 1974). High systolic blood pressure (2/17) (Hansen et al 1973)."                                                                                                                                                                                                                                                                                                                                                             
[13791] "Develop spontaneous plasmacytomas after about 8 months of age, with an incidence of about 30% in males and 16% in females. These develop rapidly, and may be detected by palpation. They usually develop in the ileocoecal lymph nodes, and about 60% of them synthesis monoclonal immunoglobulins (Bence-Jones proteins) of IgG1 (35%), IgE (36%) or IgA classes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13792] "About 50% incidence of squamous-cell carcinoma of the mouth late in life. Mean life-span 27-30 months with or without mouth tumours (Hulse 1979, Buckley et al 1980)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[13793] "DA: Urinary bladder tumours 54% in males and 14% in females, with a peak incidence at 25-30 months of age (Deerberg et al 1985). High incidence of hormone-dependent endometrial adenocarcinoma. A transplantable cell line (RUCA-I) derived from such a tumour in DA rats can produce these tumours in ectopic sites. The rate of proliferation is reduced by tamoxifen, and this cell line appears to be a suitable model for the study of molecular aspects of estrogen and tamoxifen-dependent gene expression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13794] "About 4% of spontaneous peripheral nerve tumours, with cystic schwannomas being the most frequent type. 24 spontaneous and 28 ethylnitrosourea-induced tumours has been described by Turusov and Cabral, (1994)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13795] "Strain widely used in carcinogenesis and teratogenesis studies. Highly susceptible to the transplacental induction of malignant tumours of the central nervous system by ethyl nitrosourea (Druckrey et al 1970). A transplantable monocytic-myeloid leukaemia L5222 induced by ethyl nitrosourea has been used as a model for chemotherapy (Ivankovic and Zeller 1974). Transplantable colon tumour PROb grows progressively and metastasizes, whereas REGb grows slowly and is then rejected (Blottiere et al 1992a,b)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[13796] "Frequent microphthalmia. Genetic markers described for sublines of this strain in the USA differ from those in Europe, suggesting that the US sublines were contaminated at some time in the past with LEW (Czerwinski and Crowell 1986). Mean life-span of BDII/Han 33.6 +/-4.7 months in males and 22.5+/-4.4 months in females, with 91% of females developing endometrial carcinomas, but with a more varied range of tumours in males. These include 26% adrenal phaeochromocytomas, 23% histiocytic sarcomas, 18% pituitary tumours and 14% haemangiomas. About 12% of aged male BDII/Han develop diverticula of the stomach (Kaspareit-Rittinghausen and Deerberg 1987). High incidence of hormone-dependent endometrial adenocarcinoma."                                                                                                                                                                                                                                                    
[13797] "Resistant to Cysticercus. Susceptible to oestrogen-induced mammary and adrenal tumours. Good reproduction. High open-field defecation (2/12, males, 3/12 females) and low ambulation (11/12), Harrington (1972). Low wheel activity (12/12) (Harrington 1971b). Aggressive towards handlers (Harrington 1981)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[13798] "In females tumours include 27% pituitary, 21% mammary, 3% adrenal, 9% leukaemia (generalised), 7% lymphoma (malignant), 3% lipomas and 4% unclassified (Kim et al 1960). Mean life span 21 months in females and 23 months in males. Leukaemia 15-22% characterised by an unusual type of mononuclear cell containing reddish granules. Incidence of spontaneous pituitary tumours 38% in rats older than 10 months of age, increasing to a maximum of 69% at 28-32 months of age. Higher incidence in females (71%) than in males (35%)"                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13799] "High incidence (97% in females, 36% in males) of spontaneous thymomas starting from about one year of age. They sometimes caused dyspnea, and were occasionally the cause of death, but were not associated with any myopathies or autoimmune disease (Murray et al 1985)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13800] "Median survival 113 weeks in males, 108 weeks in females. Spontaneous tumours 46% testes,16% adrenal, 5% pituitary, 6% skin and ear duct and fewer of other types in males; 21%pituitary, 13% uterus, 11% mammary gland, 6% adrenal and fewer of other types in females.  Will grow transplantable Morris hepatomas 3924A which can be used as a model for the treatment of liver cancer (Yang et al 1995)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[13801] "Very docile. Susceptible to the induction of autoimmune thyroiditis. Low and intermediate antibody responses to 1 and 10 g BSA, respectively. Low antibody response to streptococcal group A carbohydrate; not linked to the MHC. High relative heart weight in 10-week old males (20/23)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[13802] "BB: The development of lymphocytic thyroiditis is not affected by iodine treatment according to Allen (1992), though Ebner et al (1992) found the opposite. Epitope specificities of collagen-induced arthritis studied by Cremer et al (1992). A lymphopenic, nondiabetic substrain BB-DR has very low T-cell numbers, depressed B-lymphocyte numbers and a complete absence of peripheral CD8+ T cells characteristics of the susceptible BB strain(Joseph et al 1993). Transfusing of BB-DR thymocytes into nude rats transfers the autoimmune insulin-dependent diabetes mellitus (Whalen et al 1995)."                                                                                                                                                                                                                                                                                                                                                                                         
[13803] "BN: Tumours of epithelium 28% in males, 2% in females. Ureter tumours 20% in females, 6% in males. Most common neoplastic lesions in males were urinary bladder carcinoma 35%, pancreas islet adenoma 15%,pituitary adenoma 14%, lymphoreticular sarcoma 14%, adrenal cortex adeneoma 12%, medullarythyroid carcinoma 9%, adrenal pheochromocytoma 8%. Four other types of tumours were observed. In females: pituitary adenoma 26%, ureter carcinoma 22%, adrenal cortical adenoma19%, cervix sarcoma 15%, mammary gland fibroadenoma 11%, islet adenoma 11%. Twelve other tumour types were observed (Burek and Hollander 1975a)."                                                                                                                                                                                                                                                                                                                                                                
[13804] "BUF: Low incidence of dental caries. Spontaneous tumours of anterior pituitary 30%, and of adrenal cortex 25% in older animals. Survival 58% at 2 years of age with thyroid carcinoma in 25% (Lindsey et al 1968). Low incidence of renal neoplasms (Snell 1967). High incidence of tumours of the anterior pituitary, adrenal medulla and adrenal cortex in animals over 18 months old (Snell1965)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13805] "Spontaneous tumours of the thymus (Dunning and Curtis 1946, Dunning et al 1947)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13806] "Non-insulin-dependent overt diabetes: blood glucose 384+/- 134 mg/dl (plasma insulin at 60 min following intragastric glucose load 83.3 +/-10.2mU/mL) and hypertension blood pressure 176 +/-8mmHg. There was severe diffuse diabetic glomerulosclerosis and severe hypertensive changes in arteries and arterioles characterised by fibrinoid necrosis and/or onion skin lesions as well as smooth muscle hyperplasia. Myocardial changes were prominent, with foci of ischemic necrosis and hyperplastic vascular changes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13807] "DONRYU: Spontaneous tumours 74% in males at 120-weeks, mostly pituitary adenomas, phaeochromocytomas and insulinomas. In females incidence 89%, mostly uterine adenocarcinomas, mammary fibroadenomas and pituitary adenomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[13808] "Has platelet storage disease associated with the red-eyed yellow locus, as described by Raymond and Dodds (1975) for the FH strain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13809] "Most animals older than 2 years exhibit small local areas of nephritis; less than 25% show severe nephritis (Snell 1967). Tumours: Mammary tumours 41% in females and 23% in males, pituitary adenomas 36% in females and 24% in males, testicular interstitial cell tumours 85% in males. Other tumour types less common (Sass et al 1975). Thyroid carcinoma 22% (Lindsey et al 1968). Interstitial cell testicular tumours 65%, mononuclear cell leukaemia 24%, subcutaneous fibroadenoma 9% in females. Both sexes have a 5% incidence of nodular hyperplasia of the liver."                                                                                                                                                                                                                                                                                                                                                                                                                    
[13810] "It has been suggested that FH rats represent a genetic model of depression They have altered serotonergic function (Aulka et al, 1994a), they exhibit differential responses to serotonic agonists and antagonists compared with other strains (Meehan and Schechter, 1994), and long-term treatment with imipramine, clomiprimine and clorgyline produced significant decreases in plasmacorticosterone levels, supporting this suggestion (Aulaka et al, 1993)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13811] "Origin: An outbred stock of fawn hooded rats introduced into Europe by Tschopp in the early 1970s. Maintained as an outbred stock until the mid-1980s, then brother x sister mating initiated by A.P. Provoost to produce two strains designated FHH (also known as FHR) and FHL, which differ in hypertension and proteinuria.  FHH develops focal and segmental glomerular sclerosis, systemic hypertension and proteinuria at a young age, but these effects are more marked in FHH than FHL (Simons et al, 1993). The renal disease and hypertension are under independent genetic control, and both appear to be independent of the red-eyed dilution gene which causes platelet storage disease (Brown et al,1996)"                                                                                                                                                                                                                                                                           
[13812] "GH: Develops hypertension, cardiac hypertrophy and vascular disease (Phelan 1968, Simpson and Phelan 1984, Simpson et al, 1994). Genetic hypertension in GH (but not SHR) may be associated with a defect in renal prostaglandin catabolism (Armstronag et al 1976)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13813] "Vigorous and healthy, but high incidence of physical abnormalities. Skulls of young fragile through weaning. High death rate from hemorrhage due to blood platelet disease (Harrington 1981). Long latency to emerge into familiar environment (12/12 males, 10/12 females) (Harrington 1971a). High open field exploration in females (3/12) (Harrington 1972). Low wheel activity (11/12 males10/12 females) (Harrington 1971b)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13814] "Carries a mutation causing fulminated hepatitis and jaundice at about four months of age. Clinical symptoms include severe jaundice, bleeding, oliguria, loss of body weight and elevation of serum levels of bilirubin and hepatic enzymes. About half the animals die within a week of onset, and in survivors hepatocellular carcinoma spontaneously appears after 1-1.5 years (Kasai et al 1990,Sasaki 1985, Wirth et al 1990)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13815] "Of the large spectrum of 52 histologically different types of tumours, the highest incidence was observed for adenomas of the pituitary and adenomas/adenocarcinomas of the adrenal cortex in both sexes, mammary gland tumours and endometrial carcinomas (45%) in females, and C-cell adenomas/adenocarcinomas of the thyroid gland and tumours of the haemopoietic system (28%) in males (Baum et al, 1995)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[13816] "LH: The strain exhibits mild hypertension (approx 165mmHg in males and 140mmHg in females at 14 weeks of age in 1984) with increased body weight and plasma lipids. There is reduced life-span (compared with LN and LL) with histopathological lesions characterisitc of hypertensive disease in rats."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13817] "Low frequency of pancreatic exocrine tumours. By 12-15 months of age develop small local areas of nephritis that progress by 22-24 months to moderate to severe nephritis in 75% of animals (Snell 1967). About 33% of females over 18 months develop tumours of the uterus of endometrial origin. Adrenocortical adenomas (about 20% in males and 40% in females over 18 months of age), and phaeochromocytomas or preneoplastic nodules in adrenal medulla (about 67% of males over 21 months of age) (Snell 1965). Low blood pressure (21/23), reaching 121_1.2 (SEM) mmHg at 10 weeks of age. Resistant to development of methlycholanthrene -induced thyroiditis (Glover et al 1969)."                                                                                                                                                                                                                                                                                                         
[13818] "Good reproductive performance. Hyperplasia and dysplasia of the dorsolateral prostate caused by implantation of testosterone and estradiol-17-filled silastic capsules. Prolonged implantation leads to prostatic carcinoma (Leav et al 1988, 1989)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[13819] "Tumours (atriocaval epithelial mesotheliomas) of right atrium or inferior vena cava occur in approximately 12-20% of animals of both sexes over 1 year. These tumours are slow growing, but apparently malignant, and closely resemble similar tumours found in humans (Goodall et al1975). In a later study, most common neoplasms of animal over one year of age: atrioclavalmesotheliomas 12%, lung adenomas 10% (males), pituitary adenomas 23%, mammary tumours7%, liver tumours 3%, cervical tumours 3% (in females) (Goodall and Doesburg 1981)."                                                                                                                                                                                                                                                                                                                                                                                                                                            
[13820] "SHR: rats develop hypertension spontaneously without exception at the age of 7-15 weeks. There is a systolic blood pressure plateau of about 200 mmHg. The genetic basis is polygenic, with at least three major genes involved (Tanase and Suzuki 1971, Yen et al 1974). There is a high incidence of cardiovascular disease (Okamoto et al 1973), but a low incidence of stroke which can be increased to about 30% with chronic stress (Yamori 1984)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[13821] "Inherited overproduction of free radicals, high levels of lipid peroxidation, protein oxidation, DNA rearrangements, morbid conditions mimicking human degenerative diseases: cataract, emphysema, cardiomyopathy, carcinogenesis; short life-span and low fecundity. Intensive transport of monosaccharides into the cells (Salganik et al 1994)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[13822] "Tumours: medullary thyroid carcinoma 27%, chromophobe adenoma of the pituitary 68%, adrenal cortical adenoma 29%, pheochromocytoma 2%, islet cell adenoma 1%. Mean life-span more than 31months in females and 22 months in males (Boorman et al 1972). Mean life-span 31 months in females with pituitary tumours found in 69% of females. Other common tumours include medullary thyroid carcinoma 40%, adrenal cortical adenoma 29%, fibroadenoma of breast 21% with 19 other types of tumour found in 290 animals (Boorman and Hollander 1973)."                                                                                                                                                                                                                                                                                                                                                                                                                                                
[13823] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13824] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13825] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13826] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13827] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13828] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13829] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13830] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13831] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13832] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13833] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13834] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13835] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13836] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13837] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13838] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13839] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13840] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13841] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13842] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13843] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13844] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13845] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13846] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13847] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13848] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13849] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13850] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13851] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13852] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13853] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13854] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13855] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13856] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13857] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13858] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13859] "This random bred stock was developed at the Institute for Cancer Research (Fox Chase Cancer Center) by Dr. T.S. Hauschka beginning in 1948. Dr. Hauschka developed the high production and high growth rate characteristics of the Icr:Ha(ICR) stock by rigid selection over a period of several years. When he left the Institute for Cancer Research in 1954, Dr. Hauschka took part of his HA(ICR) colony with him to Roswell Park Memorial Institute in Buffalo, N.Y. The remainder of the colony was left at Fox Chase where a modified version of Robertson's mating system has been used to minimize the rate of inbreeding. In agreement with Dr. Hauschka, Fox Chase designates its random bred stock \"Icr:Ha(ICR)\" to differentiate it from Dr. Hauschka's stock since the two colonies probably began to drift apart genetically very shortly after August, 1959. (from taconic.com)"                                                                                                  
[13860] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13861] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13862] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13863] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13864] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13865] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13866] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13867] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13868] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13869] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13870] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13871] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13872] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13873] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13874] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13875] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13876] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13877] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13878] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13879] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13880] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13881] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13882] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13884] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13885] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13886] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13887] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13888] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13889] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13891] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13892] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13893] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13894] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13895] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13896] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13897] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13898] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13899] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13900] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13901] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13902] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13903] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13906] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13907] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13910] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13911] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13912] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13913] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13914] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13915] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13916] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13917] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13918] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13919] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13920] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13922] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13923] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13924] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13927] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13928] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13929] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13932] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13933] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13934] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13935] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13936] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13937] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13938] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13939] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13940] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13941] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13942] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13943] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13944] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13945] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13946] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13948] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13949] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13950] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13951] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13952] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13953] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13954] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13955] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13956] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13957] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13958] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13960] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13961] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13963] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13965] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13966] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13968] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13969] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13970] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13971] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13972] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13973] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13974] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13975] "Inbr: 66. Genet: A^w . Origin: Dunn, 1936. (Jackson Labs/Festing)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[13976] "Inbr (El) 93. Agouti: +. Origin: From 101/Rl to El, then presumed genetic contamination. Differs from 101 at the a, Car2, Gpi1^s, Hba and lop2 loci. Maint. by H, El. (Jackson Labs/Festing)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[13977] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13979] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13980] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13981] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13982] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13984] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13985] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13986] "Inbr (Pas) N9 (1994). Under white, uw. Origin: Wild allele of under white found segregating in a Corsican mouse, backcrossed 9 times to 129/Sv. (Jackson Labs/Festing)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[13987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13988] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13991] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13993] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13994] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13995] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13998] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[13999] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14001] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14002] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14004] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14005] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14007] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14008] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14009] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14010] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14011] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[14514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14515] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14516] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14517] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14518] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14519] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14522] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14523] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14524] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14526] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14527] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14529] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14531] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14534] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14535] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14536] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14537] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14538] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14539] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14540] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14541] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14542] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14543] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14544] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14545] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14546] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14547] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14548] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14549] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14550] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14551] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14552] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14553] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14554] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14555] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14556] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14557] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14558] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14559] "Inbr and colour depends on substrain (see below). Origin: Dunn 1928 from crosses of coat colour stocks from English fanciers and a chinchilla stock from Castle. This strain has a common origin with strain 101. Most substrains carry the white-bellied agouti gene AW though only a subset have the agouti pattern as many carry albino or chinchilla and/or the pink-eyed dilution gene, p, which is derived from Asian mice of the Mus musculus type (see also strains SJL, P/J and FS/Ei). (Jackson Labs/Festing)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14560] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14561] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14562] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14563] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14564] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14565] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14566] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14568] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14569] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14570] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14571] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14572] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14573] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14574] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14575] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14576] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14577] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14578] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14579] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14580] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14581] "A member of the immunoglobulin supergene family .  Co-regulator of T cell activation with CD86.  Plays a critical role in autoimmune, humoral, and transplant responses.  Expressed on activated T and B cells and on macrophages.  (from PROW)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14582] "leukocyte surface antigen long known as the sheep red blood cell receptor (SRBCR); involved in helper and cytotoxic T lymphocyte activation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[14583] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14584] "Technique for treating certain painful conditions and for producing regional anesthesia by passing long thin needles through the skin to specific points.  The free ends of the needles are twirled or in some cases used to conduct a weak electric current. Anesthesia sufficient to permit abdominal, thoracic, and head and neck surgery has been produced by the use of acupuncture alone. The patient is fully conscious during the surgery. Acupuncture has been known in the Far East for centuries but received little attention in Western cultures until the early 1970s. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                     
[14585] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14586] "A classification system with 7 major categories and 18 sub-categories for operationalizing research agendas.  Major categories include: Mind-body medicine (with OBSSR); Alternative medical systems; Lifestyle & disease prevention (with ODP); Biological based therapies (with ODS); Manipulative and body based systems; Biofields; and Bioelectro-magnetics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[14587] "(am-pyoo-TAY-shun) Surgery to remove part or all of a limb or appendage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[14588] "(i) the systematic study of clinical and basic science and its application for the reduction of pain and suffering; (ii) the blending of tools, techniques and principles taken from the discrete healing art disciplines and reformulated as a holistic application for the reduction of pain and suffering; and (iii) a newly emerging discipline emphasizing an interdisciplinary approach with a goal of reduction of pain and suffering. (AAPM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14589] "(an-es-THEE-zha) Drugs or substances that cause loss of feeling or awareness. Local anesthetics cause loss of feeling in a part of the body. General anesthetics put the person to sleep."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[14590] "Methods which refine, reduce, or replace the use of animals in research. (from CSP2000)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14591] "Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14592] "The use of operant conditioning, including rewards and punishments, in helping a person create an atmosphere where he or she does not contribute to painful stimuli."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14593] "Studies of motivating factors influencing health practices as well as efforts to modify these practices. (RAEB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14594] "A method of learning to voluntarily control certain body functions such as heartbeat, blood pressure, and muscle tension with the help of a special machine.  This method can help control pain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14595] "(by-o-LAHJ-i-kul...) BRM. Treatment to stimulate or restore the ability of the immune system to fight infections and other diseases. Also used to lessen side effects that may be caused by some cancer treatments. Also known as biological therapy, immunotherapy, or biotherapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[14596] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14597] "(BY-op-see) The removal of cells or tissues for examination under a microscope. When only a sample of tissue is removed, the procedure is called an incisional biopsy or core biopsy. When an entire lump or suspicious area is removed, the procedure is called an excisional biopsy. When a sample of tissue or fluid is removed with a needle, the procedure is called a needle biopsy or fine-needle aspiration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14598] "The removal of tissue or fluid with a needle for examination under a microscope. Also called fine-needle aspiration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14599] "(fer-E-sis) A procedure in which blood is collected, part of the blood such as platelets or white blood cells is taken out, and the rest of the blood is returned to the donor. Also called apheresis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[14600] "The administration of blood or blood products into a blood vessel."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[14601] "(BY-op-see) The removal of a sample of tissue from the bone marrow with a needle for examination under a microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14602] "(trans-plan-TAY-shun) A procedure to replace bone marrow destroyed by treatment with high doses of anticancer drugs or radiation. Transplantation may be autologous (an individual's own marrow saved before treatment), allogeneic (marrow donated by someone else), or syngeneic (marrow donated by an identical twin)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[14603] "(ray-dee-AY-shun) A procedure in which radioactive material sealed in needles, seeds, wires, or catheters is placed directly into or near a tumor. Also called brachytherapy, internal radiation, or interstitial radiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[14604] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14605] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14606] "Removal or destruction of the testicles or ovaries using radiation, surgery, or drugs. Medical castration refers to the use of drugs to suppress the function of the ovaries or testicles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[14607] "(KAW-ter-ih-ZAY-shun) The destruction of tissue with a hot instrument, an electrical current, or a caustic substance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[14608] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14609] "experimental condition created by disrupting cells with homogenization, sonication, detergents, or other treatment, leaving intracellular components exposed to controlled manipulation of the medium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[14610] "The continuous sequential physiological and psychological maturing of the child from birth up to but not including adolescence. It includes healthy responses to situations, but does not include growth in stature or size (= GROWTH). (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14611] "RAEB: Category for studies relating to children, for which no other child-specific RAEB category is available."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14612] "A system that seeks to utilize the recuperative powers of the body and the relationship between the musculoskeletal structures and functions of the body, particularly of the spinal column and the nervous system, in the restoration and maintenance of health. (From Stedman, 25th ed) (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[14613] "RAEB-2: Cholesterol role in cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[14614] "A type of research study that tests how well new medical treatments or other interventions work in people.  Such studies test new methods of screening, prevention, diagnosis, or treatment of a disease.  The study may be carried out in a clinic or other medical facility.  Also called a clinical trial."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[14615] "A type of research study that tests how well new medical treatments or other interventions work in people.  Such studies test new methods of screening, prevention, diagnosis, or treatment of a disease.  The study may be carried out in a clinic or other medical facility.  Also called a clinical study."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[14616] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14617] "(ko-LEK-toe-mee) An operation to remove the colon. An open colectomy is the removal of the colon through a surgical incision made in the wall of the abdomen. Laparoscopic-assisted colectomy uses a thin, lighted tube attached to a video camera. It allows the surgeon to remove the colon without a large incision."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14618] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14619] "(ko-LAHS-toe-mee) An opening into the colon from the outside of the body. A colostomy provides a new path for waste material to leave the body after part of the colon has been removed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[14620] "RAEB: Use of two or more simultaneous or consecutive treatment modalities; e.g., surgery + radiation, or radiation + immunotherapy. Does not refer to use of two or more chemotherapeutic agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[14621] "Diagnostic, therapeutic and preventive health services provided for individuals in the community."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[14622] "(kray-nee-AH-toe-mee) An operation in which an opening is made in the skull."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[14623] "(KRYE-o-SIR-jer-ee) Treatment performed with an instrument that freezes and destroys abnormal tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[14624] "(kyoo-reh-TAHZH) Removal of tissue with a curette, a spoon-shaped instrument with a sharp edge."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14625] "(sis-TEK-toe-mee) Surgery to remove all or part of the bladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14626] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14627] "The concept concerned with all aspects of providing and distributing health services to a patient population."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[14628] "Development, improvement, or testing of methods for cancer detection; methods for staging tumors; also promotion of screening programs, education concerning cancer signs and symptoms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14629] "(dye-AL-ih-sis) The process of cleansing the blood when the kidneys are not able to filter the blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[14630] "Food and drink regularly consumed or prescribed for a special reason. Used for human or animal populations. (PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[14631] "Carbohydrates present in food comprise digestible sugars and starches and indigestible cellulose and other dietary fibers. The former are the major source of energy. The sugars are in beet and cane sugar, fruits, honey, sweet corn, corn syrup, milk and milk products, etc.; the starches are in cereal grains, legumes, tubers, etc. (From Claudio & Lagua, Nutrition and Diet Therapy Dictionary, 3d ed, p32, p277) (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14632] "RAEB-2: Role of dietary fats in cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14633] "RAEB: Use for experimental studies or clinical interventions to clarify the effects of different types or levels of dietary fiber in relation to cancer prevention."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[14634] "(dye-LAY-shun and kyoo-reh-TAHZH) D&C. A minor operation in which the cervix is expanded enough (dilation) to permit the cervical canal and uterine lining to be scraped with a spoon-shaped instrument called a curette (curettage). Also called D&C or dilatation and curettage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[14635] "The process of cutting apart or separating tissue as, for example, in the study of anatomy or in the course of a surgical procedure. (MedicineNet.com)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[14636] "A clinical trial in which neither the medical staff nor the person knows which of several possible therapies the person is receiving."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[14637] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14638] "(EM-bo-lih-ZAY-shun) The blocking of an artery by a clot or foreign material. Embolization can be done as treatment to block the flow of blood to a tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[14639] "ERT. Hormones (estrogen, progesterone, or both) given to postmenopausal women or to women who have had their ovaries surgically removed. Hormones are given to replace the estrogen no longer produced by the ovaries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[14640] "(ree-SEK-shun) Removal of tissue or part or all of an organ by surgery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14641] "RAEB-2: Role of unsaturated fats in cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14642] "Study in which persons exposed to risk or given a designated preventive or therapeutic regimen are observed over a period or at intervals to determine the outcome of the exposure or regimen. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14643] "RAEB-2: Substances which are of little or no nutritive value, but are used in the processing or storage of foods or animal feed; includes ANTIOXIDANTS, FOOD PRESERVATIVES, FOOD COLORING AGENTS, FLAVORING AGENTS, ANTI-INFECTIVE AGENTS, VEHICLES, EXCIPIENTS and other similarly used substances. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[14644] "(gas-TREK-toe-mee) An operation to remove all or part of the stomach."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[14645] "A large collection of cloned DNA fragments from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14646] "Application of genetic material (usually DNA) into cells in order to permanently correct an inherited disease or an acquired disease such as cancer.  The genetic material as 'naked' DNA can be delivered into the cells alone or can be delivered into cells by different types of vectors such as viruses which may contain DNA or RNA.  Gene therapy techniques attempt to replace a faulty/missing gene associated with a particular disease, mediate localized delivery of a protein producing specified therapeutic effects, or introduce new cellular functions.  Gene therapies are designed to deliver genetic material into somatic cells and not germ cells, so that only cells of patients and not those of their offspring contain and express the genetic material delivered. (NCI04)"                                                                                                                                                                                               
[14647] "The concept concerned with all aspects of providing and distributing health services to a patient population.  Includes the services rendered by members of the health profession and non-professionals under their supervision for the benefit of the patient. (DCCPS and from Dorland, 28th ed.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[14648] "A communication process between a specially trained health professional and a person concerned about the genetic risk of disease.  The person's family and personal medical history may be discussed, and counseling may lead to genetic testing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[14649] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14650] "Health Maintenance Organization. Organized systems for providing comprehensive prepaid health care that have five basic attributes: 1) provide care in a defined geographic area; 2) provide or ensure delivery of an agreed-upon set of basic and supplemental health maintenance and treatment services; 3) provide care to a voluntarily enrolled group of persons; 4) require their enrollees to use the services of designated providers; and 5) receive reimbursement through a predetermined, fixed, periodic prepayment made by the enrollee without regard to the degree of services provided. (From Facts on File Dictionary of Health Care Management, 1988) (from MSH98)"                                                                                                                                                                                                                                                                                                               
[14651] "Encouraging consumer behaviors most likely to optimize health potentials (physical and psychosocial) through health information, preventive programs, and access to medical care. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[14652] "The degree to which individuals are inhibited or facilitated in their ability to gain entry to and to receive care and services from the health care system. Factors influencing this ability include geographic, architectural, transportational, and financial considerations, among others."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14653] "The integration of epidemiologic, sociological, economic, and other analytic sciences in the study of health services. Health services research is usually concerned with relationships between need, demand, supply, use, and outcome of health services. The aim of the research is evaluation, particularly in terms of structure, process, output, and outcome. (From Last, Dictionary of Epidemiology, 2d ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[14654] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14655] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14656] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14657] "Surgery to remove all or part of the liver."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14658] "NIH: Subcategory of Biological Based Therapies in CAM. This sub-category addresses plant-derived preparations used for therapeutic and preventive purposes.  Included are: Individual herbs - Ginkgo biloba, Hypericum, Garlic, Ginseng, Echinacea, Saw palmetto, Urtica diocia (nettle), Kava kava, Hawthorne, Witch Hazel, Bilberry, Ginger, Aloe vera, Capsicum, Feverfew, Green tea, Tee Tree oil, Licorice root, Yohimbe, Valerian, Bee Pollen, Cat's Claw, Evening Primrose, Dong Quai, Fenugreek, Marshmallow, Psyllium, Tumeric. Combinations include: Padma 28, Hoxey, Essiac, Saw palmetto, pygeum africanium."                                                                                                                                                                                                                                                                                                                                                                           
[14659] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14660] "(HOS-pis) A program that provides special care for people who are near the end of life and for their families, either at home, in freestanding facilities, or within hospitals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14661] "Management of the internal organization of the hospital."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[14662] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14663] "Surgical excision of the Hypophysis cerebri.  Often used in the treatment of metastatic bone pain, estrogen positive breast cancer, and prostate cancer pain. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14664] "(hiss-ter-EK-toe-mee) An operation in which the uterus is removed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[14665] "(il-ee-AHS-toe-mee) An opening into the ileum, part of the small intestine, from the outside of the body. An ileostomy provides a new path for waste material to leave the body after part of the intestine has been removed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[14666] "A technique used to cause an immune response that results in resistance to a specific disease, especially an infectious disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14667] "use of antibodies or primed lymphocytes from an immune donor to produce immunity against an antigenic substance or organism in a nonimmune host."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14668] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14669] "Suppression of the body's immune system and its ability to fight infections or disease. Immunosuppression may be deliberately induced with drugs, as in preparation for bone marrow or other organ transplantation to prevent rejection of the donor tissue. It may also result from certain diseases such as AIDS or lymphoma or from anticancer drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[14670] "(IM-yoo-no-THER-a-pee) Treatment to stimulate or restore the ability of the immune system to fight infections and other diseases. Also used to lessen side effects that may be caused by some cancer treatments."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14671] "In the laboratory (outside the body). The opposite of in vivo (in the body)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[14672] "Nutrition of children from birth to 2 years of age. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14673] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14674] "(lap-a-RAH-toe-mee) A surgical incision made in the wall of the abdomen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[14675] "(LAIR-in-JEK-tuh-mee) An operation to remove all or part of the larynx (voice box)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[14676] "The use of a laser either to vaporize surface lesions or to make bloodless cuts in tissue. It does not include the coagulation of tissue by laser (LASER COAGULATION). (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14677] "Removal of the blood to collect specific blood cells; the remaining blood is returned to the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[14678] "(lye-GAY-shun) The process of tying off blood vessels so that blood cannot flow to a part of the body or to a tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14679] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14680] "(lo-BEK-toe-mee) The removal of a lobe."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14681] "In medicine, a study or clinical trial in which participants are identified and then followed forward in time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14682] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14683] "A surgical procedure in which the lymph nodes are removed and examined to see whether they contain cancer. For a regional lymph node dissection, some of the lymph nodes in the tumor area are removed; for a radical lymph node dissection, most or all of the lymph nodes in the tumor area are removed. Also called lymph node dissection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[14684] "A therapeutic method of manipulation, methodical pressure, friction, and kneading of the body. (from Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[14685] "(mas-TEK-toe-mee) Surgery to remove the breast (or as much of the breast tissue as possible)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[14686] "(mas-TEK-toe-mee) Surgery for breast cancer in which the breast, some of the lymph nodes under the arm, the lining over the chest muscles, and sometimes part of the chest wall muscles are removed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14687] "(RAD-ih-kal mas-TEK-toe-mee) Surgery for breast cancer in which the breast, chest muscles, and all of the lymph nodes under the arm are removed.  For many years, this was the operation most used, but it is used now only when the tumor has spread to the chest muscles.  Also called the Halsted radical mastectomy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[14688] "An operation to remove the breast cancer but not the breast itself. Types of breast-conserving surgery include lumpectomy (removal of the lump), quadrantectomy (removal of one quarter of the breast), and segmental mastectomy (removal of the cancer as well as some of the breast tissue around the tumor and the lining over the chest muscles below the tumor)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[14689] "(mas-TEK-toe-mee) Removal of the breast. Also called simple mastectomy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14690] "Subcategory of Alternative Medical Systems in CAM. This systems of practice includes acupuncture, acupressure, herbal applications, massage, diet, and exercises. These practices, especially in the form of Traditional Chinese Medicine have a prominent position in the U.S. Included are: Acupuncture, Herbal formulas, Diet, QiGong, Tai chi, Massage, manipulation, Acupotomy - Fibrosis, Fibromylogic electroacupuncture used in China at Great Wall Hospital."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[14691] "A drugless system of therapy, making use of physical forces such as air, light, water, heat, massage, etc. (Dorland, 27th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[14692] "(nef-REK-toe-mee) Surgery to remove a kidney. Radical nephrectomy removes the kidney, the adrenal gland, nearby lymph nodes, and other surrounding tissue. Simple nephrectomy removes only the kidney. Partial nephrectomy removes the tumor but not the entire kidney."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14693] "RAEB: Clinical research carried out by nurses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14694] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14695] "The protein, carbohydrates, fats and cofactors required to maintain a healthy body"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[14696] "(or-kee-EK-toe-mee) Surgery to remove one or both testicles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[14697] "RAEB: See SIC 58 (bone marrow transplantation)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14698] "(AHS-toe-mee) An operation to create an opening (a stoma) from an area inside the body to the outside.  Colostomy and urostomy are types of ostomies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[14699] "(o-o-for-EK-toe-mee) Surgery to remove one or both ovaries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14700] "Care that prevents or relieves the symptoms of disease or the side effects of treatment. Palliative care does not alter the course of a disease but can improve the quality of life. It attempts to meet the physical, emotional, spiritual, and practical needs of patients by helping to relieve pain, depression, or other problems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14701] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14702] "(pan-kree-a-TEK-toe-mee) Surgery to remove all or part of the pancreas. In a total pancreatectomy, part of the stomach, part of the small intestine, the common bile duct, gallbladder, spleen, and nearby lymph nodes also are removed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[14703] "Bathing an organ or tissue with a fluid. In regional perfusion, a specific area of the body (usually an arm or a leg) receives high doses of anticancer drugs through a blood vessel. Such a procedure is performed to treat cancer that has not spread."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[14704] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14705] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14706] "A method of delivering fluids and drugs directly into the abdominal cavity through a thin tube."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14707] "The activity of drugs in the body over a period of time, including the processes by which drugs are absorbed, distributed in the body, localized in the tissues, and excreted."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14708] "(foe-toe-dye-NAM-ik) Treatment with drugs that become active when exposed to light.  These drugs kill cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[14709] "Treatment of disease, especially neonatal jaundice and certain neoplasms, with visible light, including LASERS. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14710] "The use of exercises and physical activities to help condition muscles and restore strength and movement.  For example, physical therapy can be used to restore arm and shoulder movement and build back strength after breast cancer surgery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14711] "The initial study examining a new method or treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[14712] "(plas-ma-fer-EE-sis) The process of separating certain cells from the plasma in the blood by a machine; only the cells are returned to the person. Plasmapheresis can be used to remove excess antibodies from the blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[14713] "(noo-mo-NEK-toe-mee) An operation to remove an entire lung."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14714] "NIH Emphasis Area -- The term \"prevention\" refers to prophylactic and preventative efforts to achieve a significant reduction in cancer incidence, cancer mortality, and cancer morbidity.  \"Primary prevention\" involves efforts to directly prevent and/or inhibit malignant transformation; to identify, characterize, and manipulate factors that might be effective in achieving that inhibition; and attempts to promote preventative measures, such as appropriate training of scientists and clinicians. Prevention and intervention efforts are biologic activities aimed at the cell - at the genetic and cellular changes that result in the transformation process and that define cancer development."                                                                                                                                                                                                                                                                             
[14715] "(pros-ta-TEK-toe-mee) An operation to remove part or all of the prostate. Radical (or total) prostatectomy is the removal of the entire prostate and some of the tissue around it."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[14716] "A method of treating disease, esp. psychic disorders, by mental rather than pharmacological means (e.g., suggestion, re-education, hypnotism, and psychoanalysis). (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[14717] "Management of public health organizations or agencies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[14718] "Insertion of a thin needle or tube into the abdomen to remove fluid from the peritoneal cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14719] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14720] "The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by scintillation counting."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14721] "(RAY-dee-AY-shun) The use of high-energy radiation from x-rays, gamma rays, neutrons, and other sources to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external-beam radiation therapy) or from materials called radioisotopes. Radioisotopes produce radiation and can be placed in or near the tumor or in the area near cancer cells. This type of radiation treatment is called internal radiation therapy, implant radiation, interstitial radiation, or brachytherapy. Systemic radiation therapy uses a radioactive substance, such as a radiolabeled monoclonal antibody, that circulates throughout the body."                                                                                                                                                                                                                                                                                                                                
[14722] "3C; Product Evaluation, Research, and Monitoring; Diagnostic Reagents and Test Kits (FMB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[14723] "RAEB: Restoration, following disease, illness, or injury, of the ability to function in a normal or near normal manner."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14724] "A therapeutic regimen in which the patient is guided by the therapist into alternate relaxation and flexing of muscles throughout the body as a method of pain control.  It is related to guided imagery and distraction and attention therapies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[14725] "Surgery performed after cancer treatment to assess the results of prior treatment and to plan possible future treatment. (http://info.cancer.ca/e/glossary/S/Second-Look_Surgery.htm)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[14726] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14727] "Systematic investigation into a subject in order to discover facts, to establish or revise a theory, or to develop a plan of action based on the facts discovered."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[14728] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14729] "RAEB: Collections, software, or web site information available to researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14730] "(RES-pih-ra-tor-ee) Exercises and treatments that help improve or restore lung function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[14731] "(sal-PIN-go o-o-for-EK-toe-mee) Surgical removal of the fallopian tubes and ovaries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14732] "consumer (patients or their families or friends) performance of medical activities traditionally performed by professional health care providers; for daily self maintenance (dressing, hygiene, eating, etc.), use FUNCTIONAL ABILITY."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14733] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14734] "Freezing sperm for use in the future. This procedure can allow men to father children after loss of fertility."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14735] "A procedure in which a needle is put into the lower part of the spinal column to collect cerebrospinal fluid or to give anticancer drugs intrathecally. Also called a spinal tap."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[14736] "(splen-EK-toe-mee) An operation to remove the spleen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[14737] "(SERJ-uh-ree) A procedure to remove or repair a part of the body or to find out whether disease is present.  An operation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[14738] "Surgery performed on the digestive system or its parts. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14739] "Surgery involving the eyes"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[14740] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14741] "Surgery performed on the urinary tract or its organs and on the male or female genitalia. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[14742] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14743] "RAEB: NCI Efficacy, safety, cost-effectiveness of technological advances."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[14744] "A procedure for critical evaluation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14745] "(thor-a-KAH-toe-mee) An operation to open the chest."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14746] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14747] "A repository of the tissue specimen, cells or cell lines, for experimental purpose. It can be from different diseases or different parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[14748] "Surgery to remove the entire pancreas. Part of the stomach, part of the small intestine, the common bile duct, gallbladder, spleen, and nearby lymph nodes also are removed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[14749] "(TRAY-kee-AHS-toe-mee) Surgery to create an opening (stoma) into the windpipe. The opening itself may also be called a tracheostomy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14750] "The replacement of tissue with tissue from the person?s own body or from another person."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[14751] "(TRANZ-yoo-REE-thral ree-SEK-shun) Surgical procedure to remove tissue from the prostate using an instrument inserted through the urethra. Also called TURP."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[14752] "A form of radiation used in the treatment of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14753] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14754] "Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14755] "Active immunization where vaccine is administered for therapeutic or preventive purposes. This can include administration of immunopotentiating agents such as BCG vaccine and Corynebacterium parvum as well as biological response modifiers such as interferons, interleukins, and colony-stimulating factors in order to directly stimulate the immune system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[14756] "(vas-EK-toe-mee) An operation to cut or tie off the two tubes that carry sperm out of the testicles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14757] "RAEB: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[14758] "Radiation therapy to the entire body. Usually followed by bone marrow or peripheral stem cell transplantation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14759] "A technique for enhancing cell-mediated immunity by either artificially increasing the number of specific immunocompetent cells through inoculation of ex-vivo expanded primarily activated cytotoxic lymphocytes, or genetically engineered lymphocytes with enhanced cytotoxic ability, or by altering tumor cells to make them more immunogenic. The concept does not refer to anticancer vaccines and immune modulation through the therapeutic use of cytokines, cell receptors, or other substances"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[14760] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14761] "inspection of one's own body, usually for signs of disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14762] "Surgery to rebuild a breast's shape after a mastectomy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14763] "Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY). (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[14764] "A type of surgery used to treat pancreatic cancer. The head of the pancreas, the duodenum, a portion of the stomach, and other nearby tissues are removed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[14765] "(eh-sof-a-JEK-toe-mee) An operation to remove a portion of the esophagus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[14766] "(STAIR-ee-o-TAK-tik...) A radiation therapy technique involving a rigid head frame that is attached to the skull; high-dose radiation is administered through openings in the head frame to the tumor while decreasing the amount of radiation given to normal brain tissue. This procedure does not involve surgery. Also called stereotaxic radiosurgery and stereotactic radiation therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14767] "Treatment that is given after the cancer has not responded to other treatments."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14768] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14769] "The removal of tissue or fluid with a needle for examination under a microscope. Also called needle biopsy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14770] "A detailed report of the diagnosis, treatment, and follow-up of an individual patient. Case reports also contain some demographic information about the patient (for example, age, gender, ethnic origin)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[14771] "heading term for medical terms other than physician specialties; for organizations and facilities, see BIOMEDICAL RESOURCE."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14772] "An arrangement whereby a third-party payer (e.g., insurance company, federal government, or corporation) mediates between physicians and patients, negotiating fees for service and overseeing the types of treatment given.  Managed care has virtually replaced unmanaged indemnity plans, where payment is automatic and oversight procedures are minimal.  Whereas 96% of American workers had unmanaged indemnity in 1984, only 28% did in 1988.  Typically, in managed care, the third-party payer requires second opinions and pre-certification review for patients requiring hospital admission.  They obtain wholesale prices from doctors, and carry out cost-containment measures, including auditing hospitals and reviewing claims.  Managed care has figured heavily in the national debate over health care."                                                                                                                                                                       
[14773] "research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome; for complete retrieval include RTs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14774] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14775] "The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14776] "An action or administration of therapeutic agents to produce an effect that is intended to alter the course of a pathologic process."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14777] "(AL-o-jen-AY-ik) A procedure in which a person receives stem cells, the cells from which all blood cells develop, from a compatible, though not genetically identical, donor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[14778] "Treatment with corticosteroid drugs to reduce swelling, pain, and other symptoms of inflammation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[14779] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14780] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14781] "An alternative medical practice.  a consciously-directed process of energy exchange during which the practitioner uses the hands as a focus to stimulate and enhance the patient's own natural healing ability. (from Skeptic's Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14782] "(DOOSH) A procedure in which water or a medicated solution is used to clean the vagina and cervix."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[14783] "A technique in which the person focuses on positive images in his or her mind."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14784] "TM.  A mental technique used to promote relaxation, reduce stress, and improve quality of life."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14785] "Treatment or therapy to reduce or eliminate a patient's allergic response to an allergen (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[14786] "A type of radiation therapy. The person is given an intravenous infusion containing the element boron, which concentrates in the tumor cells. The person then receives radiation therapy with atomic particles called neutrons from a small research nuclear reactor. The radiation is absorbed by the boron, killing the tumor cells without harming normal cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[14787] "The electronic transmission of radiological images from one location to another for the purposes of interpretation and/or consultation. Users in different locations may simultaneously view images with greater access to secondary consultations and improved continuing education. (From American College of Radiology, ACR Standard for Teleradiology, 1994, p3)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14788] "RAEB: Delivery of health services via remote telecommunications. This includes interactive consultative and diagnostic services."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14789] "All actions taken to ensure that standards and procedures are adhered to and that delivered products or services meet performance requirements."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14790] "Radiation therapy in which high-energy rays are aimed at a tumor from many angles in a single treatment session."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14791] "NIH: Subcategory of Biological Based Therapies in CAM. This sub-category deals with dietary approaches and special diets applied as alternative therapies for chronic disease in general or risk factors.  Examples include, Gerson, Wigmore, Atkins, Pritikin, McDougall, Paleolithic, Natural Hygiene, fasting, and folk and cultural foods, such as soy-based feeding, etc.  Included are: Pritikin, Ornish, McDougall, Gerson, Kelly-Gonzales, Wigmore, Livingston-Wheeler, Atkins, Diamond, Vegetarian, Fasting, High Fiber, Macrobiotic, Mediterranean, Paleolithic, Asian, Natural Hygiene."                                                                                                                                                                                                                                                                                                                                                                                                 
[14792] "(in-SIH-zhun) A cut made in the body to perform surgery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[14793] "(ek-SI-zhun-al BY-op-see) A surgical procedure in which an entire lump or suspicious area is removed for diagnosis. The tissue is then examined under a microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[14794] "(in-SI-zhun-al BY-op-see) A surgical procedure in which a portion of a lump or suspicious area is removed for diagnosis. The tissue is then examined under a microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[14795] "(BY-ahp-see) A procedure in which the parts of a mole that are above and just below the surface of the skin are removed with a small blade. There is no need for stitches with this procedure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14796] "A method of putting fluids, including drugs, into the bloodstream. Also called intravenous infusion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14797] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14798] "(ful-gyoor-AY-shun) Destroying tissue using an electric current."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14799] "(e-LEK-tro-des-ih-KAY-shun) The drying of tissue by a high-frequency electric current applied with a needle-shaped electrode."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[14800] "(thor-a-sen-TEE-sis) Removal of fluid from the pleural cavity through a needle inserted between the ribs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[14801] "(per-FYOO-zhun) A technique that may be used to deliver anticancer drugs directly to an arm or leg. The flow of blood to and from the limb is temporarily stopped with a tourniquet, and anticancer drugs are put directly into the blood of the limb. This allows the person to receive a high dose of drugs in the area where the cancer occurred.  Also called isolated limb perfusion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[14802] "Partial removal of the liver"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[14803] "(aw-TAHL-o-gus) A procedure in which bone marrow is removed from a person, stored, and then given back to the person after intensive treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14804] "(RAD-ih-kal sis-TEK-toe-mee) Surgery to remove the bladder as well as nearby tissues and organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14805] "Instillation of a solution into the bladder to provide cleansing or medication. (NIC96)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14806] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14807] "(RAD-ih-kal pros-ta-TEK-toe-mee) Surgery to remove the entire prostate. The two types of radical prostatectomy are retropubic prostatectomy and perineal prostatectomy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14808] "(peh-rih-NEE-al pros-ta-TEK-toe-mee) Surgery to remove the prostate through an incision made between the scrotum and the anus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14809] "(re-tro-PYOO-bik pros-ta-TEK-toe-mee) Surgery to remove the prostate through an incision made in the abdominal wall."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14810] "(ko-nih-ZAY-shun) Surgery to remove a cone-shaped piece of tissue from the cervix and cervical canal. Conization may be used to diagnose or treat a cervical condition. Also called cone biopsy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14811] "(en-do-SER-vih-kul kyoo-reh-TAHZH) The scraping of the mucous membrane of the cervical canal using a spoon-shaped instrument called a curette."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14812] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14813] "An attempt to prevent disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14814] "Any device, marker, or other means developed for the purpose of detecting the presence of a tumor early in its development, when it is theoretically more likely to be curable. Also education and promotion related to the benefits of early detection. (RAEB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14815] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14816] "(trans-FYOO-zhun) The infusion of components of blood or whole blood into the bloodstream. The blood may be donated from another person, or it may have been taken from the person earlier and stored until needed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[14817] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14818] "(by-o-LAHJ-i-kul...) BRM. Treatment to stimulate or restore the ability of the immune system to fight infections and other diseases. Also used to lessen side effects that may be caused by some cancer treatments. Also known as biological therapy, immunotherapy, or biotherapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[14819] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14820] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14821] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14822] "An assay based on Antibody-Dependent Cellular Cytotoxicity which involves the killing of a target cell by a killer cell by means of an antibody directed to the target by the antigen-binding arms and anchored to the killer cell via an Fc receptor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[14823] "(DYE-a-ther-mee) The use of heat to destroy abnormal cells. Also called cauterization or electrodiathermy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[14824] "immunity that results from the response of the immune system to an injection of antigen into an animal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14825] "A study in which the participants are assigned by chance to separate groups that compare different treatments; neither the researchers nor the participants can choose which group.  Using chance to assign people to groups means that the groups will be similar and that the treatments they receive can be compared objectively.  At the time of the trial, it is not known which treatment is best. It is the patient's choice to be in a randomized trial."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14826] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14827] "Any device, marker, or other means developed for the purpose of detecting the presence of disease, ussually in asymptomatic individuals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[14828] "Therapeutic use of hypnotism.  It has been used to treat phobias and anxiety, to manage pain, and to extinguish habits and addictions. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14829] "Refers to the time after menopause. Menopause is the time in a woman's life when menstrual periods stop permanently; also called \"change of life.\""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14830] "Movement of residence from one place to another. Includes nomadism; labor or seasonal migration; patterns of rural, urban, or suburban migration; or voluntary or forced relocation. (PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[14831] "Programs, techniques, or processes of treatment by which individuals acquire psychological and social skills and attitudes which facilitate community interaction.  (from PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14832] "A study in which data from different sources are \"linked\".  Usually used to compile epidemiological data.  The logic of record linkage is that two or more items of information about a person recorded at different times, and perhaps in different places, may be of greater value when considered together than when either is considered alone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[14833] "Adding nutrients to the diet."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[14834] "A large collection of data (visual, audio, text) stored and organized computer for rapid retrieval for a various uses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[14835] "(limf node dis-EK-shun) A surgical procedure in which lymph nodes are removed and examined to see whether they contain cancer. Also called lymphadenectomy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14836] "Studies that bring together multiple scientific disciplines to address specific issues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14837] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14838] "(per-IF-er-al) A method of replacing blood-forming cells destroyed by cancer treatment. Immature blood cells (stem cells) in the circulating blood that are similar to those in the bone marrow are given after treatment to help the bone marrow recover and continue producing healthy blood cells. Transplantation may be autologous (an individual's own blood cells saved earlier), allogeneic (blood cells donated by someone else), or syngeneic (blood cells donated by an identical twin). Also called peripheral stem cell support."                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[14839] "A method of replacing immature blood-forming cells that were destroyed by cancer treatment. The stem cells are given to the person after treatment to help the bone marrow recover and continue producing healthy blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14840] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14841] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14842] "Spread and adoption of inventions and techniques from one geographic area to another, from one discipline to another, or from one sector of the economy to another. For example, improvements in medical equipment may be transferred from industrial countries to developing countries, advances arising from aerospace engineering may be applied to equipment for persons with disabilities, and innovations in science arising from government research are made available to private enterprise. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[14843] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14844] "NIH: Major category of larger classification Complementary and Alternative Medicine.  This category deals with behavioral, psychological, social and spiritual approaches to medicine not commonly used or accepted.  See also -- Mind-Body Systems; Mind-Body Methods; Religion and Spirituality; Social and contextual areas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14845] "RAEB: study of food and water contaminants as potential carcinogens"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[14846] "Use of techniques, biologically active substances, and procedures to enhance or restore the ability of the host immune system to fight cancer. Also used to lessen adverse effects that may be caused by some cancer treatments."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14847] "Physician Data Query.  PDQ is an online database developed and maintained by the National Cancer Institute.  Designed to make the most current, credible, and accurate cancer information available to health professionals and the public, PDQ contains peer-reviewed summaries on cancer treatment, screening, prevention, genetics, and supportive care; a registry of cancer clinical trials from around the world; and directories of physicians, professionals who provide genetics services, and organizations that provide cancer care. Most of this information is available on the Cancer.gov Web site.  More specific information about PDQ can be found at http://cancer.gov/cancer_information/pdq/."                                                                                                                                                                                                                                                                                  
[14848] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14849] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14850] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14851] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14852] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14853] "Treatment that adds, blocks, or removes hormones.  For certain conditions (such as diabetes or menopause), hormones are given to adjust low hormone levels.  To slow or stop the growth of certain cancers (such as prostate and breast cancer), hormones may be given to block the body's natural hormones.  Sometimes surgery is needed to remove the source of hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14854] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14855] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14856] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14857] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14858] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14859] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14860] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14861] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14862] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14863] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14864] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14865] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14866] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14867] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14868] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14869] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14870] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14871] "The synergistic action of two drugs, being greater than the sum of the effects of each used alone.(Online Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[14872] "The use of a drug that makes tumor cells more sensitive to radiation therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[14873] "Bone marrow transplantation in which the donor and recipient are genetically identical."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14874] "The use of an intensely powerful beam of light to kill cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14875] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14876] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14877] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14878] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14879] "Administration of a body substance to compensate for the loss, as from disease or surgery, of a gland or tissue that would normally produce the substance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[14880] "Treatment to block production of adrenal hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[14881] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14882] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14884] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14885] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14886] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14887] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14888] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14889] "Treatment with drugs used to block production or interfere with the action of male sex hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14891] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14892] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14893] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14894] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14895] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14896] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14897] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14898] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14899] "Refers to the time before menopause. Menopause is the time of life when a women's menstrual periods stop permanently; also called \"change of life.\""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[14900] "ER+. Breast cancer cells that have a protein (receptor molecule) to which estrogen will attach. Breast cancer cells that are ER+ need the hormone estrogen to grow and will usually respond to hormone (antiestrogen) therapy that blocks these receptor sites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14901] "ER-. Breast cancer cells that do not have a protein (receptor molecule) to which estrogen will attach. Breast cancer cells that are ER- do not need the hormone estrogen to grow and usually do not respond to hormone (antiestrogen) therapy that blocks these receptor sites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14902] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14903] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14904] "(PR+) PR+. Breast cancer cells that have a protein (receptor molecule) to which progesterone will attach. Breast cancer cells that are PR+ need the hormone progesterone to grow and will usually respond to hormonal therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[14905] "(PR-) PR-.  Breast cancer cells that do not have a protein (receptor molecule) to which progesterone will attach. Breast cancer cells that are PR- do not need the hormone progesterone to grow and usually do not respond to hormonal therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14906] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14907] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14910] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14911] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14912] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14913] "A treatment for Epstein-Barr virus infection or overgrowth of white blood cells (lymphocytes) after an organ or bone marrow transplant.  Specific lymphocytes from a sibling donor are infused into the patient to try and reverse these conditions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[14914] "Treatment to manage or alleviate the fatigue and weight loss often associated with cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[14915] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14916] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14917] "A type of nutritional support.  It is particularly useful when oral nutrition is unfeasible, impractical or inadequate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14918] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14919] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14920] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14922] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14923] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14924] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14927] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14928] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14929] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14932] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14933] "(a-ROW-ma-tays in-hib-ISH-un) Prevention of the formation of estradiol, a female hormone, by interfering with an aromatase enzyme.  Aromatase inhibition is a type of hormone therapy used in postmenopausal women who have hormone-dependent breast cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[14934] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14935] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14936] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14937] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14938] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14939] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14940] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14941] "The use of drugs to protect normal tissue from damage by cancer therapy agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14942] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14943] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14944] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14945] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14946] "A specific treatment protocol used in a clinical trial."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14948] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14949] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14950] "Treatment with an antibody, a substance that can directly kill specific tumor cells or stimulate the immune system to kill tumor cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[14951] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14952] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14953] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14954] "Early detection of breast cancer involving asymptomatic women. Generally done in the population with higher risk, due to envirnomental or genetic factors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[14955] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14956] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14957] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14958] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14960] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14961] "RAEB: Anything, such as drug administration or lifestyle changes, designed to inhibit the onset of breast cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[14962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14963] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14965] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14966] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14968] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14969] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14970] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14971] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14972] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14973] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14974] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14975] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14976] "Antiangiogenesis therapy is the use of drugs or other substances to stop cancerous tumors from developing new blood vessels. Without a blood supply, tumors can't grow much larger than the eye of a needle"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[14977] "The destruction of bone marrow using radiation or drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[14978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14979] "Drug therapy aimed at forcing cancer cells to resume the process of maturation and therefore to induce tumor to a more differentiated, less aggressive state. Differentiation therapy restrains cancer cells growth and facilitates the application of more conventional therapies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[14980] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14981] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14982] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14984] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14985] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14986] "Uses the results of a chemosensitivity testing assay to tailor the treatment to the individual."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[14987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14988] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14991] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14993] "Drug therapy in which the drug is a fusion protein generated by molecular biology procedures.  The fusion protein combines a cell targeting moiety, such as an antibody fragment, with an effector moiety, like a bacterial toxin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[14994] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14995] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14998] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[14999] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15001] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15002] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15004] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15005] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15007] "HRT. Hormones (estrogen, progesterone, or both) given to postmenopausal women or women who have had their ovaries surgically removed, to replace the estrogen no longer produced by the ovaries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15008] "The first step in testing a new treatment in humans. These studies test the best way to give a new treatment (for example, by mouth, intravenous infusion, or injection) and the best dose. The dose is usually increased a little at a time in order to find the highest dose that does not cause harmful side effects. Because little is known about the possible risks and benefits of the treatments being tested, phase I trials usually include only a small number of patients who have not been helped by other treatments."                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15009] "A study to test whether a new treatment has an anticancer effect (for example, whether it shrinks a tumor or improves blood test results) and whether it works against a certain type of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15010] "A study to compare the results of people taking a new treatment with the results of people taking the standard treatment (for example, which group has better survival rates or fewer side effects). In most cases, studies move into phase III only after a treatment seems to work in phases I and II. Phase III trials may include hundreds of people."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15011] "After a treatment has been approved and is being marketed, it is studied in a phase IV trial to evaluate side effects that were not apparent in the phase III trial. Thousands of people are involved in a phase IV trial."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15012] "(KEE-mo-pre-VEN-shun) The use of drugs, vitamins, or other agents to try to reduce the risk of, or delay the development or recurrence of, cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15013] "Studies of the role of trace elements, obtained through diet, on general health"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15014] "The application of non-invasive finger pressure along energy points throughout the body in order to relieve pain and induce a feeling of well-being."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15015] "A diagnosis made from a study of the signs and symptoms of a disease. (STED98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15016] "(STAY-jing) Performing exams and tests to learn the extent of the cancer within the body, especially whether the disease has spread from the original site to other parts of the body. It is important to know the stage of the disease in order to plan the best treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15017] "(an-AS-ta-MO-sis) A procedure to connect healthy sections of tubular structures in the body after the diseased portion has been surgically removed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15018] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15019] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15020] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15021] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15022] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15023] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15024] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15025] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15026] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15027] "Treat bacterial infections with antibiotics"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15028] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15029] "A procedure that uses radiolabeled substances to detect tumors for surgical removal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15030] "IORT. Radiation treatment aimed directly at a tumor during surgery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15031] "A combination drug therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15032] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15033] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15034] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15035] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15036] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15037] "Men who eat a vegan diet have lower levels of IGF-I, a protein associated with prostate cancer.  These findings suggest that a diet without meat or dairy products could reduce the risk of prostate cancer. (from Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15038] "(as-per-AY-shun) Removal of fluid from a lump, often a cyst, with a needle and a syringe."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15039] "(kee-mo-THER-a-pee) Treatment with anticancer drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15040] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15041] "A fusion protein of the MUC-1 colorectal cancer surface marker with HSP70 as a carrier.  In trials as a cancer vaccine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15042] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15043] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15044] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15045] "Analyzing DNA to look for a genetic alteration that may indicate an increased risk for developing a cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15046] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15047] "The injection of umbilical cord blood to restore an individual's own blood production system suppressed by anticancer drugs, radiation therapy, or both. It is being studied in the treatment of cancer and severe blood disorders such as aplastic anemia. Cord blood contains high concentrations of stem cells needed to produce new blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15048] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15049] "An injection of an anesthetic drug into the space between the wall of the spinal canal and the covering of the spinal cord."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15050] "(dye-SEK-shun) Surgery to remove lymph nodes and other tissues in the neck."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15051] "(as-per-AY-shun) The removal of a small sample of bone marrow (usually from the hip) through a needle for examination under a microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15052] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15053] "A measurement of the energy content of food.  The body needs calories as \"fuel\" to perform all of its functions, such as breathing, circulating the blood, and physical activity.  When a person is sick, their body may need extra calories to fight fever or other problems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15054] "(MEE-dee-a-stin-AH-toe-mee) A procedure in which a tube is inserted into the chest to view the tissues and organs in the area between the lungs and between the breastbone and heart. The tube is inserted through an incision next to the breastbone. This procedure is usually used to get a tissue sample from the lymph nodes on the left side of the chest. Also called the Chamberlain procedure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15055] "The administration of a fluid into a blood vessel, usually over a prolonged period of time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15056] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15057] "Radiation therapy using electron beam"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15058] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15059] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15060] "The act of developing or preparing a drug, or the final product itself."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15061] "Dividing the total dose of radiation therapy into several smaller, equal doses delivered over a period of several days."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15062] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15063] "see NTs for specifics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15064] "General term for hemodialysis, plasmapheresis, and related procedures involving autologous removal, alteration, and replacement of patients' blood or blood components.  Also includes blood transfusions. (from CSP98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15065] "Resarch on variety of aspects of diet/nutrition and cancer (e.g. the role of diet in preventing and treating cancer), or the effect of cancer on one's nutritional status; for the effect of diet as a factor or cause of cancer, use NUTRITION RELATED NEOPLASM/CANCER."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15066] "The study of how nutritional needs change with aging."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15067] "1E1; Basic Science Research (includes vaccine and chemotherapy development); Vaccines; Development"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15068] "American Type Culture Collection.  ATCC is a global nonprofit bioscience organization (located at 10801 University Boulevard, Manassas, VA 20110-2209 703-365-2700) that provides biological products, technical services, and educational programs to private industry, government, and academic organizations around the world.  Biological products for academic and industrial labs, as well as educational and technical services.  For the collection, preservation and distribution of cultures of living microorganisms, viruses, DNA probes, plants, and human and animal"                                                                                                                                                                                                                                                                                                                                                                                                                 
[15069] "The use of drugs to protect nerve cells from damage by cancer therapy agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15070] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15071] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15072] "Treatment designed to be used as a first step toward shrinking the cancer and in evaluating response to drugs and other agents. Induction therapy is followed by additional therapy to eliminate whatever cancer remains."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15073] "The use of electrodes to heat and destroy abnormal tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15074] "Removal and examination of the sentinel node(s) (the first lymph node(s) to which cancer cells are likely to spread from a primary tumor). To identify the sentinel lymph node(s), the surgeon injects a radioactive substance, blue dye, or both near the tumor.  The surgeon then uses a scanner to find the sentinel lymph node(s) containing the radioactive substance or looks for the lymph node(s) stained with dye. The surgeon then removes the sentinel node(s) to check for the presence of cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15075] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15076] "All methods of preventing cancer including limit of exposure to carcinogens and infectious agents, diet, education, etc"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15077] "A procedure using heat to remove tissue or a part of the body, or destroy its function.  For example, to remove the lining of the uterus, a catheter is inserted through the cervix into the uterus, a balloon at the end of the catheter is inflated, and fluid inside the balloon is heated to destroy the lining of the uterus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15078] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15079] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15080] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15081] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15082] "(AD-joo-vant) Treatment given after the primary treatment to increase the chances of a cure. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, or biological therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15083] "Treatment to suppress or block the production of male hormones. Androgen suppression is achieved by surgical removal of the testicles, by taking female sex hormones, or by taking other drugs, antiandrogens. Also called androgen ablation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15084] "(AK-sil-air-ee) Surgery to remove lymph nodes found in the armpit region.  Also called axillary lymph node dissection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15085] "A single dose of drug usually injected into a blood vessel over a short period of time.  Also called bolus infusion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15086] "Chemotherapy treatments given after induction chemotherapy to further reduce the number of cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15087] "The removal of a tissue sample with a needle for examination under a microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15088] "Anticancer drugs that kill cells, especially cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15089] "The strength of a treatment given over a period of time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15090] "Having to do with the space between the wall of the spinal canal and the covering of the spinal cord. An epidural injection is given into this space."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15091] "A procedure in which a warmed solution containing anticancer drugs is used to bathe, or is passed through the blood vessels of, the tissue or organ containing the tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15092] "Grown in the laboratory under controlled conditions. (For instance, white blood cells can be grown in special conditions so that they attack specific cancer cells when returned to the body.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15093] "A procedure in which a catheter is placed into the artery that provides blood to the liver; another catheter is placed into the vein that takes blood away from the liver. This temporarily separates the liver's blood supply from blood circulating throughout the rest of the body and allows high doses of anticancer drugs to be directed to the liver only."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15094] "Treatment that affects cells in the tumor and the area close to it."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15095] "Treatment that is given to help a primary (original) treatment keep working. Maintenance therapy is often given to help keep cancer in remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15096] "Treatment used to make cancer cells less resistant to anticancer drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15097] "Treatment that inhibits blood cell production."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15098] "Surgery, radiation therapy, or a drug treatment to stop the functioning of the ovaries. Also called ovarian ablation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15099] "The time of a woman's life when menstrual periods become irregular. Refers to the time near menopause."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15100] "A trial to study the safety, dosage levels, and response to a new treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15101] "A trial to study response to a new treatment and the effectiveness of the treatment compared with the standard treatment regimen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15102] "Surgical removal of the region of the breast (approximately one quarter) containing cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15103] "A radiation therapy technique that delivers radiation directly to the tumor while sparing the healthy tissue. Also called radiation surgery and stereotactic external beam irradiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15104] "A treatment plan that specifies the dosage, the schedule, and the duration of treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15105] "(sis-TEM-ik THER-a-pee) Treatment using substances that travel through the bloodstream, reaching and affecting cells all over the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15106] "Treatment to destroy T cells, which play an important role in the immune response. Elimination of T cells from a bone marrow graft from a donor may reduce the chance of an immune reaction against the recipient's tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15107] "Therapy used to eliminate estrogen in the body. This may be done with surgery, radiation therapy, chemotherapy, or a combination of these procedures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15108] "Surgery to remove the entire uterus, including the cervix. Sometimes, not all of the cervix is removed. Also called complete hysterectomy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15109] "Surgery that is aided by the use of a video camera that projects and enlarges the image on a television screen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15110] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15111] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15112] "(TRANZ-yoo-REE-thral ree-SEK-shun) Surgery performed with a special instrument inserted through the urethra."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15113] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15114] "EPT. Treatment that generates electrical pulses through an electrode placed in a tumor to enhance the ability of anticancer drugs to enter tumor cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15115] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15116] "Analyzing DNA to look for a genetic alteration that may indicate an increased risk for developing a specific disease or disorder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15117] "Therapy to help control nicotine withdrawal symptoms during tobacco cessation"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15118] "Studies identifying, testing, and implementing interventions among groups of individuals that are designed to prevent the initiation of a substance, such as tobacco or alcohol."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15119] "RAEB: procedures or treatment processes designed to prevent complications; e.g., modifying a drug or surgical procedure to prevent complications."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15120] "NIH: Used as subcategory of Mind-Body Medicine in CAM.  This area deals with the non-behavioral aspects of spirituality and religion that examine their relationship to biological function or clinical conditions.  It included activities such as prayer, soul retrieval, spiritual healing, Included are: Prayer, Confession, Nonlocality, Nontemporality, Consciousness studies, Spirituality constructs (Love, hope, faith, joy, etc.), Soul retrieval (see Indigenous practices), Spiritual healing, \"Special\" healers (see \"Biofield\")."                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15121] "Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts. (Webster, 3rd ed) Precedes applied research which is the translation of basic research into the practical application of such new or revised conclusions, theories, or laws. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15122] "Research directed toward solving a specific problem (as opposed to Basic Research)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15123] "Multidisciplinary study done at the population level or among the population groups, generally to find the cause, incidence or spread of the disease or to see the response to the treatment, nutrition or environment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15124] "The visual appearance of a chromosome when stained and examined under a microscope. Particularly important are visually distinct regions, called light and dark bands, which give each of the chromosomes a unique appearance. This feature allows a person's chromosomes to be studied in a clinical test known as a karyotype, which allows scientists to look for chromosomal alterations. (NHGRI Glossary of Genetic Terms)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15125] "Small doses of medicines, herbs, or both that are believed to stimulate the immune system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15126] "The systematic collection, analysis, and interpretation of health data on an ongoing basis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15127] "The study of the biochemical and physiological effects of drugs and the mechanisms of their actions, including the correlation of actions and effects of drugs with their chemical structure, also, such effects on the actions of a particular drug or drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15128] "The study of factors determining and influencing the frequency and distribution of disease, injury, and other health related events and their causes in a defined human population. (CSP2000)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15129] "Closely monitoring a patient's condition but withholding treatment until symptoms appear or change."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15130] "A surgical procedure in which the doctor creates a new pathway for the flow of body fluids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15131] "(IN-gwin-al or-kee-EK-toe-mee) An operation in which the testicle is removed through an incision in the groin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15132] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15133] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15134] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15135] "An alternative medical practice.  The practitioners of reiki believe that health and disease are a matter of the life force being disrupted.  Reiki healers claim to channel reiki into \"diseased\" individuals for \"rebalancing.\" (from Skeptic's Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15136] "One treatment after the other."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15137] "A method of delivering fluids and drugs directly to tumors in the peritoneal cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15138] "Administration of a fluid form of the drug via a blood vessel into the liver over the sustained period of time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15139] "CHPP. A procedure that bathes the abdominal cavity in fluid that contains anticancer drugs. This fluid is warmer than body temperature. This procedure appears to kill cancer cells without harming normal cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15140] "A research study that evaluates methods of detecting disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15141] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15142] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15143] "The introduction of fluids and drugs directly into the carotid artery, the main artery in the neck that carries blood from the heart to the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15144] "The delivery of a drug into a space within an organ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15145] "Treatment to manage or alleviate difficult or painful breathing or shortness of breath."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15146] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15147] "Therapy to reduce the effects of menopausal symptoms.  May also be necessary in order to counteract the effect of various chemotherapy treatments."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15148] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15149] "Anticancer drugs given to kill cancer cells that survive after remission induction therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15150] "Refers to the use of drugs to suppress the function of the ovaries or testicles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15151] "In the body. The opposite of in vitro (outside the body or in the laboratory)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15152] "A way of giving radiation therapy in smaller-than-usual doses two or three times a day instead of once a day."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15153] "The initial chemotherapy a person receives to bring about a remission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15154] "Care that prevents or relieves the symptoms of disease or the side effects of treatment. Supportive care does not alter the course of a disease but can improve the quality of life. It attempts to meet the physical, emotional, spiritual, and practical needs of patients by helping to relieve pain, depression, or other problems. Also known as comfort care, palliative care, and symptom management."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15155] "Radiation therapy to the mantle field, the spleen, the lymph nodes in the upper abdomen, and the lymph nodes in the pelvic area."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15156] "Surgically removing as much of the tumor as possible."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15157] "(in-tra-THEE-kal KEE-mo-THER-a-pee) Anticancer drugs that are injected into the fluid-filled space between the thin layers of tissue that cover the brain and spinal cord."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15158] "(ray-dee-AY-shun) Radiation therapy that uses a machine to aim high-energy rays at the cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15159] "A procedure in which the blood supply to the tumor is blocked surgically or mechanically and anticancer drugs are administered directly into the tumor. This permits a higher concentration of drug to be in contact with the tumor for a longer period of time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15160] "Cancer registries gather a wide variety of specific information on cancer patients that can be analyzed to identify health disparity trends in cancer incidence, mortality and patient survival."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15161] "A GIS is an organized collection of computer hardware, software, geographic data and personnel designed to efficiently capture, store, update, manipulate, analyze and display all forms of geographically referenced information.  NCI's plan is to use geographic information systems for the assessment of environmental risk factors, identification of places and/or subpopulations where cancer surveillance and control programs are needed.  (from http://www.pitt.edu/~super1/lecture/lec1451/005.htm and http://newscenter.cancer.gov/pressreleases/gisqa.html)"                                                                                                                                                                                                                                                                                                                                                                                                                          
[15162] "(lump-EK-toe-mee) Surgery to remove the tumor and a small amount of normal tissue around it."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15163] "Systemic chemotherapy with a single agent regimen.  A regimen is described as a distinctive collection of agent(s) and/or modalities to be utilized together during a cycle or course of therapy.  All routes of administration are acceptable as long as the agent is intended for systemic therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15164] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15165] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15166] "(yoo-RAHS-toe-mee) An operation to create an opening from inside the body to the outside, making a new way to pass urine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15167] "RAEB: NCI Design, identification, synthesis, extraction, purification, modification, or characterization of potential anticancer agents; studies of their metabolism, distribution, excretion, physiological effects, molecular interactions, structural analysis, toxicity, mechanism of action, antitumor effects in vivo (nonhuman species) or in vitro (human or nonhuman), and phase I and phase II clinical trials."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15168] "Mild electrical stimulation of acupuncture points to control symptoms such as nausea and vomiting."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15169] "Surgery done with the aid of a laparoscope (a thin, lighted tube) to remove part or all of the colon through small incisions made in the wall of the abdomen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15170] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15171] "Clinical Trials with a minimum of 20% (or $100,000) relevance to the development of vaccines and therapeutics directed against AIDS-related malignancies. To include: Kaposi's sarcoma, Non-Hodgkins lymphoma, Other lymphomas, Lymphosarcomas"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15172] "Clinical trials with a minimum of 20% (or $100,000) relevance to individuals of non-Caucasian descent, and individuals of Hispanic descent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15173] "Clinical Trials with a minimum of 20% (or $100,000)relevance to the development of vaccines and therapeutics directed against opportunistic infections associated with HIV infection. To include: Pneumocystosis, toxoplasmosis, cryptosporidiosis, candidiasis, cryptococcosis, mycobacteriosis, cytomegalovirus, papillomavirus, herpes simplex, JC virus, coccidioides, hairy leukoplakia, and HIV-related periodontal disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15174] "Clinical Trials with a minimum of 20% (or $100,000) relevance to children 0-18 years of age. To include: Pregnant females, Neonates, Infants"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15175] "Clinical Trials with a minimum of 20% (or $100,000) relevance to females 12 years of age or older. To include: Pregnant women, Women at risk of AIDS, Female prostitutes, Perinatal transmission of HIV."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15176] "Support basic social sciences and behavioral research to strengthen the understanding of (a) determinants and processes that influence HIV-related risk behaviors and (b) the consequences of HIV disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15177] "RAEB: Studies of motivating factors influencing health practices as well as efforts to modify these practices."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15178] "RAEB: Research on any factor or condition, exposure to which is theoretically susceptible to behavioral modification, but in which no actual behavioral work is being done; e.g., experimental studies on tobacco, dietary components, many other environmental carcinogens."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15179] "A program set up to establish cooperative agreements for Clinical Trials of Cancer Therapy with Biological Response Modifiers (CATBRMs), for the development of novel approaches to such therapy.  Funding to foster innovative clinical trials of BRMs by peer-reviewed groups of highly experienced clinical and preclinical investigators who have the unique technical capabilities to study new agents in early clinical trials and to address hypothesis-driven issues of mechanisms of action.  (from Clinical Trials Of Cancer Therapy With Biological Response Modifiers, RFA: CA-92-28)"                                                                                                                                                                                                                                                                                                                                                                                                  
[15180] "The typing, separation, and storage of leukocytes for transfusion to recipients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15181] "RAEB: Medical or surgical interventions to eradicate breast tumors and/or their metastases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15182] "Use for any project involving actual detection of breast tumors (screening, diagnosis clinical trials), development or refinement of diagnostic techniques or devices, education or promotion of breast cancer detection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15183] "The act of discovery of a malignant neoplasm, and after treatment, the discovery of minimal residual disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15184] "NIH Emphasis Area -- The term \"prevention\" refers to prophylactic and preventative efforts to achieve a significant reduction in cancer incidence, cancer mortality, and cancer morbidity. \"Primary prevention\" involves efforts to directly prevent and/or inhibit malignant transformation; to identify, characterize, and manipulate factors that might be effective in achieving that inhibition; and attempts to promote preventative measures, such as appropriate training of scientists and clinicians. Prevention and intervention efforts are biologic activities aimed at the cell - at the genetic and cellular changes that result in the transformation process and that define cancer development"                                                                                                                                                                                                                                                                               
[15185] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15186] "In vitro or in vivo testing to give a quantitated measure of tumor-inducing potency of the substance. The concept does not refer to mutagenicity tests in bacterial and mammalian cell systems and eidemiologic studies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15187] "Suppression or prevention of the carcinogenic process/development of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15188] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15189] "RAEB: Clinical counterpart of term Chemoprevention. (See Chemoprevention.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15190] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15191] "An area of medicine that seeks to identify and treat medical disorders in humans that result from improper or inadequate diet, or from diseases that make the body unable to handle the nutrients delivered to it in the normal diet. The usual treatment is dietary, but can be the delivery of nutrients by other means. (from University of Pittsburgh Medical Center glossary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15192] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15193] "Actual observation and treatment of disease in patients (including experimental treatment) as distinct from theoretical or experimental work."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15194] "The detailed planning of studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15195] "RAEB: Clinical evaluation of the utility of diagnostic procedures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15196] "For clinical decision-making, the purposeful and ongoing acquisition, interpretation, and synthesis of patient data obtained from clinical trials."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15197] "Clinical trials that study ways of reducing the risk of getting cancer: There are two types of prevention clinical trials: 1) Action studies (doing something) and 2) Agent studies (taking something) to prevent cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15198] "RAEB: Used infrequently. Reserve for occasional small-scale testing (usually on SBIRs) of new technology in a small group of patients or normal volunteers. Does not meet the rigorous criteria of a clinical trial."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15199] "The interaction of a recipient's (patient's) immune system with an organ or tissue graft, or with the reactivity of donor-derived passenger leukocytes in the graft with the host's (patient's) body. (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15200] "Conduct clinical trials and develop new trial methodologies for the treatment of HIV infection. Trials should be designed in order to rapidly develop new therapeutic strategies, optimize clinical efficacy and proper use of available modalities, define factors that affect the success of therapeutic strategies (including the role of resistance), and advance our understanding of disease pathogenesis and progression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15201] "The Cancer Therapy Evaluation Program (CTEP) is the program within the Division of Cancer Treatment and Diagnosis (DCTD) of the NCI which plans, assesses, and coordinates all aspects of clinical trials including extramural clinical research programs, internal resources, treatment methods and effectiveness, and compilation and exchange of data as it pertains to the development and evaluation of anticancer agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15202] "The discovery of a tumor or cancer after primary, potentially curative therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15203] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15204] "1A4; Basic Science Research (includes vaccine and chemotherapy development), Biomedical Research"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15205] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15206] "Reagents and techniques used for the diagnosis of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15207] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15208] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15209] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15210] "RAEB: Self-identified projects in the Biochemistry and Pharmacology Cancer Activity. Always 100%."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15211] "Library located at Executive Plaza South"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15212] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15213] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15214] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15215] "Develop, evaluate, and implement strategies for interrupting vertical transmission of HIV from mother to child and extend our understanding of perinatal transmission and the pathogenesis of early infection (treatment of children will be addressed in other objectives). (Note: The OAR Coordinating Committee on Therapeutics feels scientific objectives 3E through 3G are of equal weight in terms of scientific priorities.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15216] "The production of laboratory animals for research"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15217] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15218] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15219] "RAEB: Usually involves maternal factors (and efforts to modify these factors) that may affect the health of the child or fetus: smoking or exposure to drugs or toxic chemicals during pregnancy, maternal/fetal immunologic interactions. Also use for genetic counseling, pregnancy and/or nursing effects on maternal health."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15220] "An act or ministration that produces an effect to alter the course of a pathologic process through the use of a variety of media, i.e., CD-ROM, Web application, video, telephone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15221] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15222] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15223] "Elucidate the progression of HIV infection, from its earliest stages through long-term sequelae."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15224] "1B; Basic Science Research (includes vaccine and chemotherapy development), Neuroscience And Neuropsychiatric Research"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15225] "The National Surgical adjuvant Breast and Bowel Project (NSABP) is a clinical trials cooperative group supported by the NCI. The group headquarters in Pittsburgh, Pennsylvania and has research sites at nearly 200 major medical centers, university hospitals, large oncology practice groups, and health maintenance organizations in the United States, Canada, Puerto Rico, and Australia. . In addition to funding from the NCI, which the NSABP has received since it began, the NSABP also receives support from other sources for ancillary studies, training, and educational programs."                                                                                                                                                                                                                                                                                                                                                                                                 
[15226] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15227] "RAEB: The science of food, the nutrients and other substances contained therein, their action, interaction, and balance in relation to health and disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15228] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15229] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15230] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15231] "RAEB: Role of dietary components in cancer causation or prevention."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15232] "RAEB: Role of saturated fats in cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15233] "The study of nutritional effects upon size, weight, and proportions of the human or other primate body. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15234] "The study of the biochemistry of foods and vitamins as they affect the body"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15235] "Resources (facilities, collections, software, information sources, etc.) available to researchers that are not listed in other concepts of Research Resources tree of NCI Metathesaurus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15236] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15237] "Supportive care that is not hospice or pain relief"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15238] "Elucidate the pathogenic mechanisms of HIV-related opportunistic infections. Enhance a bidirectional flow between basic and clinical observations and intervention programs on HIV-related complications and foster interdisciplinary collaborations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15239] "Studies of living individuals or groups of subjects (such as families, communities, or populations defined geographically or demographically), or material of human origin (such as tissues, specimens, and cognitive phenomena, etc.), for understanding of their physiologic and pathophysiologic characteristics, mechanisms of human diseases and development of approaches to diseases treatment and prevention. Includes the laboratory-based development of new forms of technology, studies of health-related professions, institutions, and systems, excludes disease-oriented studies of material, obtained from patients who were unknown to investigators."                                                                                                                                                                                                                                                                                                                             
[15240] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15241] "A collection of pharmaceutical substances available for research use"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15242] "Select candidate vaccines or concepts suitable for Phase I and Phase II trials and conduct these trials."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15243] "The Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, or PLCO Trial, is a large-scale study to determine if certain tests will reduce the number of deaths from these cancers.  Sponsored by the National Cancer Institute (NCI), the study will involve 148,000 men and women ages 55 through 74 at medical facilities in 9 geographic areas across the United States.  (Cancer Facts Screening: Questions and Answers About the PLCO Cancer Screening Trial)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15244] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15245] "Develop and assess multiple and concurrent ethical intervention strategies to reduce or prevent HIV transmission in both domestic and international settings."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15246] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15247] "Improve understanding of the biology of opportunistic pathogens, identify potential molecular targets for effective therapies, and discover and delineate the structure and function of potential agents for prevention and treatment of HIV-associated OIs and other infections that are modified by HIV infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15248] "1C2; Basic Sciences Research (includes vaccine and chemotherapy development); Behavioral Research; Prevention of high-risk behaviors (behavioral and pharmacologic interventions)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15249] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15250] "Theraputic, nutritional, environmental, social and or behavioral interventions at the societal, community, organizational or individual levels to reduce, modify or stop the course of a disese."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15251] "Study of dietary animal protein/amino acids in relation to cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15252] "Study of dietary non-animal protein/amino acids in relation to cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15253] "The use of ionizing radiation to kill cancer cells"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15254] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15255] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15256] "RAEB: Radiotherapy using radioactive particles that deposit a high amount of energy by radiation per unit length of travel."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15257] "Radiotherapy using radioactive particles that deposit a low amount of energy by radiation per unit length of travel. (from RAEB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15258] "The killing of target cells by changing the natural specificity of cytotoxic T cells by the use of an antibody or other molecule capable of binding to both the T cell and to the target cell.  Often involves hybrid (bispecific) antibodies having distinct specificities for the T cell and for the target cell. (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15259] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15261] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15262] "The SCLD maintains information about state legislation and regulation addressing cancer-related topics, including tobacco, breast cancer, genetics, cervical cancer, prostate cancer, testicular cancer, colon cancer, ovarian cancer, access to state-of-the-art cancer treatment, cancer registries, and selected issues related to diet and nutrition, employment discrimination, environmental exposure, and occupational exposure.  The purpose of the SCLD is threefold; it provides necessary information: 1) for evaluating the effect of state legislation on public health and on the application of cancer control science, 2) for facilitating the application of cancer control science, and 3) for monitoring legislative trends that may reflect changing public attitudes and practices. (State Cancer Legislative Database Program)"                                                                                                                                               
[15263] "RAEB: Patient interventions to rate the relative effectiveness of methods designed to find better ways to prevent, detect, diagnose, or treat cancer. (OCC)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15264] "Determining the efficacy of a particular therapy or treatment"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15265] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15266] "Studies of the role of the trace element fluoride, obtained through diet, on general health"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15267] "Studies of the role of the trace element mercury, obtained through diet, on general health"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15268] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15269] "Translational research requires interdependence between basic and clinical investigators in both the planning and implementation of research and emphasizes clinical application of basic research findings with patients and populations. Translational research also applies clinical findings to advance basic research that ultimately may lead to hypothesis-driven clinical trials or prevention and control interventions (from Specialized Programs Of Research Excellence In Prostrate Cancer NIH Guide, Volume 23, Number 33, September 16, 1994, RFA: CA-94-031)"                                                                                                                                                                                                                                                                                                                                                                                                                        
[15270] "A repository of tumor samples and non-tumorous tissues collected and stored under controlled circumstances. Bank's mandate is also to provide researchers with corresponding pathological and clinical data on samples."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15272] "Apply findings from basic, epidemiologic, and clinical research to the design and evaluation of vaccine strategies in laboratory studies and animal models, and foster collaboration with industry in the research and development of candidate vaccines."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15273] "Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent AIDS. Some vaccines containing antigens are recombinantly produced."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15274] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15276] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15277] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15278] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15279] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15280] "Select suitable vaccine candidates and support efficacy trials when appropriate criteria are met."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15281] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15282] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15283] "RAEB: Experimental or epidemiological studies of viruses as carcinogens or co-carcinogens. Not used where virus is merely a tool, such as a vector for gene therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15284] "Clinical services at the physical site of employment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15285] "RAEB: Research on fertility, contraceptives, transplacental carcinogenesis or other in utero or pre-conception disease induction."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15286] "NIH Emphasis Area: Infrastructure activities are new or expanded programs in the following: Research Training; Shared Instrumentation and Services; Technology Development; Information Technology and Clinical Research. Again, only new or expanded program initiatives should be reported-e.g., an increase in training related only to the increase in stipends should not be reported as an Infrastructure Initiative."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15287] "NIH Emphasis Area -- New emphasis on the biology of brain disorders reflects the extraordinary rate at which the neurosciences, with strong support from the fields of molecular genetics, imaging, and cell biology, is growing.  Efforts in neural development; neurodegeneration, especially in Alzheimer's disease, Parkinson's disease, mental illness and traumatic injury to the brain and spinal cord are few examples of the promise of this field."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15288] "NIH Emphasis Area -- Innovative approaches to pathogenesis, resulting from more precise understanding of genes, proteins, and cells, are transforming traditional descriptions of disease processes.  For example, research in this arena will uncover new mechanisms of carcinogenesis and cardiovascular disease and will lead to better understanding of osteoarthritis, birth defects and growth disorders.  These new insights into pathogenesis are, in turn, stimulating new preventive strategies against disease such as the development of new vaccines against a variety of pathogens."                                                                                                                                                                                                                                                                                                                                                                                                  
[15289] "NIH Emphasis Area: Research in new procedures and approaches to prevent disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15290] "NIH Emphasis Area -- The result of efforts in chemistry, structural biology, genetics, and cellular and molecular biology are providing new means to design therapies for a variety of diseases.  Efforts to discover and develop drugs to combat cancer and drug and alcohol addiction and methods of bioengineering to repair tissues are ripe for discovery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15291] "NIH Emphasis Area -- Recent advances in basic biology, genetics, diagnosis, and health care have all been closely linked to the development of new research instruments and computer hardware and software.  Improvements in the detection of early cancers and technologies to better visualize the living body in health and disease states will provide a wealth of knowledge that can lead to new and improved diagnostics, treatments and prevention strategies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15292] "NIH: This area (subcategory of CAM) involves whole systems of mind-body practice that are used largely as primary interventions for disease.  They are rarely delivered alone but usually are in combination with lifestyle interventions or part of a traditional medical systems.  To be placed in this class the project should include the evaluation of a combination of at least three of the \"mind-body methods\" listed below (I b) and be used as a major adjunct to \"standard care\" or as an alternative to standard care without such components."                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15293] "NIH: This sub-category (of CAM) contains numerous specific modalities used in mind-body approaches to health.  Examples are meditation, hypnosis, biofeedback, support groups, etc.  These are often considered conventional practice and become CAM related when applied to conditions for which they are not usually used, such as hypnosis for genetic problems, support groups for cancer survival, meditation to slow aging.  Included are: Psychotherapy, Meditation, Imagery, Hypnosis, Biofeedback, Support groups, Art therapy, Music therapy, Dance therapy, Journalizing, Humor, Body psychotherapy (see Massage, etc.), Yoga (see Ayurveda), Qi Gong (see Chinese medicine), Tai Chi (see Chinese medicine)"                                                                                                                                                                                                                                                                            
[15294] "NIH: Subcategory of Mind-Body Medicine in CAM classification.  This area deals with social, cultural, symbolic and contextual interventions not covered in other areas.  For example, the study cross-cultural explanatory models, placebo or \"meaning response\" research, and caring-based approaches to health care fall into this category.  Included are: Placebo, Explanatory models, Caring-based approaches, Community- based approaches, Intuitive diagnosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15295] "NIH: Major category of Complementary and Alternative Medicine classification.  This category involves complete systems of theory and practice that are alternatives to the Western biomedical approach.  Includes: Acupuncture and oriental medicine; Traditional Indigenous Systems; Unconventional Western systems; and Naturopathy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15296] "Subcategory of Alternative Medical Systems in CAM. This sub-category refers to major indigenous systems of medicine other than acupuncture and traditional oriental medicine. It includes systems such as Ayurvedic medicine, Native American Medicine, Unani-Tibbi, Kampo, Traditional African systems and community based traditional medical systems. This sub-category may become subdivided further as these systems become better studied and more familiar in the U.S. Included are: Native American Medicine, Ayurvedic Medicine, Unani-Tibbi, SADHU, Kampo Medicine, Traditional African Medicine, Traditional Aboriginal Medicine, Curahdersimo, Central and South American practices, Psychic surgery."                                                                                                                                                                                                                                                                                  
[15297] "NIH: Subcategory of alternative medical systems in CAM.  This sub-category deals with alternative medical systems developed in the West that are not dealt with elsewhere.  This includes systems such as homeopathy, Anthroposophically- extended Medicine, Environmental Medicine, Functional Medicine, Radionics, Cayce-based therapies, etc.  Included are: Homeopathy, Environmental Medicine, Functional Medicine, Anthroposophically-extended medicine, Radionics, Radiesthesia, Psionic medicine, Cayce-based systems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15298] "Influence of social factors, such as community, policy, and legislation on cancer control and outcomes"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15299] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15300] "Repository of cell samples"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15301] "Develop and evaluate new laboratory assays, behavioral methods, and statistical techniques for epidemiologic studies. (FMB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15302] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15303] "Shared facilities which provide services of a particular area of expertise"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15304] "Cancer causation research studies the events involved in the initiation and promotion of cancer. It encompasses chemical and physical carcinogenesis, biological carcinogenesis, epidemiology, chemoprevention, and nutrition research. Studies focus on external agents such as chemicals, radiation, fibers and other particles, viruses, parasitic infections, and host factors such as hormone levels, nutritional and immunologic status, and the genetic endowment of the individual, all of which contribute to the initiation and promotion of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15305] "NIH: Major category of Complementary and Alternative Medicine. This category deals with theories and practices designed to prevent the development of illness, identify and treat risk factors, or support of healing and recovery processes.  It is concerned with integrated approaches for the prevention and management of chronic disease-in-general (DIG) or the common determinants of chronic disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15306] "NIH: Subcategory of Lifestyle and Disease Prevention in CAM. This sub-category deals with unconventional approaches whose purpose is to screen for and prevent health-related imbalances, dysfunction's and disease.  Examples include, unconventional screening and diagnostic practices, such as electro-dermal diagnostics, medical intuition, chiriography, functional cellular enzyme measures, and preventive practices such as panchakarma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15307] "NIH: Subcategory of Lifestyle and Disease Prevention in CAM.  This sub-category deals with complete systems of lifestyle management that include: behavioral, dietary, exercise, stress management, addiction control These approaches must be used as major adjuncts to \"standard care\" or be applied as alternative treatments to conventional medicine practices.  To be classified in this section the project must include at least four of the five above \"core\" components of lifestyle management.  Examples are the Ornish or Pritikin programs.  These therapies are usually in combination with behavioral medicine systems."                                                                                                                                                                                                                                                                                                                                                        
[15308] "NIH: Major category of Complementary and Alternative Medicine. This category deals with natural and biologically- based interventions and practices."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15309] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15310] "No prior cancer treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15311] "Having received extensive radiation before the present time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15312] "Cancer therapy using ionizing radiation to a limited (< 50%) portion of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15313] "NIH: (Subcategory of Biological Based Therapies in CAM.) This sub-category deals with products and procedures applied in an unconventional manner that are not covered in other categories. Examples include EDTA, ozone, hydrogen peroxide, Coley's toxins, apitherapy, prolotherapy, 714X, antineoplastons, and cartilage products, etc.  Included are: Coley's toxins, Mistletoe, Antineoplastons, Cartilage, EDTA, Ozone, H202, Hyperbaric oxygen, IAT, 714X, MHT-68, Gallo immunotherapy, Induced Remission Therapy, Cone Therapy, Revici system, Enzyme therapies, Cell therapy, Enderlin products, Cell Therapy, Bee pollen.  Procedures/devices include Apitherapy, Neural Therapy (Prolotherapy), Electrodiagnostics, Iridology, Special Functional Tests, Chirography, MORA Device."                                                                                                                                                                                                      
[15314] "A category of Complementary and Alternative Medicine: procedures which rely upon movement and manipulation of the body, eg. Chiropractic. (from NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15315] "Massage & Body Techniques This sub-category (of Manipulative & Body-Based Systems in CAM) deals with massage and other body work methods such as the Alexander technique, Rolfing and Bioenergetics, Manipulative Osteopathy etc., Osteopathic Manipulative Therapy (OMT), Cranial-sacral OMT, Swedish massage, Chinese TUINA massage & acupressure, Reflexology, Rolfing, Polarity, Body psychotherapy (see Behav. Med.), Trager body work, Alexander technique, Feldenkreis technique, Applied kinesiology, NCSA-chiropractic. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15316] "NIH: Unconventional Physical Therapies. This sub-category (of Manipulative & Body-Based Therapies in CAM) considers unconventional physical therapies or combinations of conventional and unconventional therapies such as hydrotherapy, diathermy, light and color therapies, colonics, alternate nostril breathing techniques, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15317] "A category of Complementary and Alternative Medicine.  This category involves systems that use \"subtle energy\" fields in and around the body for medical purposes. Examples include Therapeutic Touch, Reiki, Hunna, laying-on-of-hands, external Qi-Gong, etc. Included are: Therapeutic Touch, Healing Science, Healing touch, Natural healing, SHEN, Mariuel, Reiki, Huna, External QiGong, Biorelax."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15318] "NIH: BIOELECTRO-MAGNETICS - This category (of Manipulative & Body-Based Systems in CAM) deals with unconventional uses of electromagnetic fields, both exogenous and endogenous such as extremely low magnetic fields, the measurement of cellular bioluminescence, the application of AC or DC fields for bone repair or anti-neoplastic activity, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15319] "(kee-mo-THER-a-pee) Treatment with anticancer drugs directed to a specific area of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15320] "(pro-fih-LAK-tik KRAY-nee-ul ir-ray-dee-AY-shun) Radiation therapy to the head to reduce the risk that cancer will spread to the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15321] "(kee-mo-THER-a-pee) Treatment with anticancer drugs in a lotion or cream applied to the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15322] "(TRAY-kee-o-eh-SOF-uh-JEE-al PUNK-chur) A small opening made by a surgeon between the esophagus and the trachea. A valve keeps food out of the trachea but lets air into the esophagus for esophageal speech."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15323] "(pro-fih-LAK-sis) Chemotherapy or radiation therapy given to the central nervous system (CNS) as a preventive treatment. It is given to kill cancer cells that may be in the brain and spinal cord, even though no cancer has been detected there."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15324] "(ar-TEE-ree-al EM-bo-lih-ZAY-shun) The blocking of an artery by a clot of foreign material. This can be done as treatment to block the flow of blood to a tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15325] "RAEB: use of chemicals to enhance the immune system in treatment of cancer"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15326] "RAEB: Role of plant-derived nutrients in cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15327] "RAEB: Study of protein/amino acids in relation to cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15328] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15329] "RAEB: Used as \"Tobacco and Health\". The all-inclusive tobacco category. Other tobacco-related categories (smoking and behavior, passive smoking, and smokeless tobacco) are included, whether deal with epidemiology, prevention, education, experimental carcinogenesis, identification of tobacco carcinogenesis co-factors (e.g. genes, enzymes) or inhibitors, manufacturing processes, filter composition or structure, tobacco radiation or pesticide content, etc. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15330] "The Cancer Genome Anatomy Project (CGAP) is an interdisciplinary program to establish the information and technological tools needed to decipher the molecular anatomy of a cancer cell.  The Cancer Genome Anatomy Project (CGAP) will unite the newest technologies, along with those both cost-effective and capable of high-throughput, to identify all the genes responsible for the establishment and growth of cancer.  CGAP has two overall goals: 1. Enhance discovery of the acquired and inherited molecular changes in cancer. 2. Evaluate the clinical potential of these discoveries. This requires the creation and dissemination of technologies that can read and interpret the molecular features of cancer. (NCBI-CGAP Conceptual tour (http://www.ncbi.nlm.nih.gov/ncicgap))"                                                                                                                                                                                                   
[15331] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15332] "RAEB-2: alcoholic beverages"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15333] "RAEB-2: Role of dietary trace minerals in cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15334] "RAEB-2: Use for studies involving not only B vitamins, but their precursors and analogs as well. These studies can involve dietary epidemiology, prevention, therapy, or any other relationship of the vitamin to cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15335] "RAEB: Use for studies involving not only vitamin C, but its precursors and analogs as well. These studies can involve dietary epidemiology, prevention, therapy, or any other relationship of the vitamin to cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15336] "RAEB: Use for studies involving not only alpha-tocopherol, but its precursors and analogs as well. These studies can involve dietary epidemiology, prevention, therapy, or any other relationship of the vitamin to cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15337] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15338] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15339] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15340] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15341] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15342] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15343] "Practice within a given segment of a society or a population."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15344] "A comprehensive, collaborative infrastructure, linked to an informatics structure, to help speed the genetic and epidemiologic study of heritable cancers. Twelve participating institutions are located in the United States, Canada, and Australia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15345] "NCI Initiative to integrate the cytogenetic and physical maps of the human genome, generate a repository of BAC clones arrayed across the genetic and physical map, and to develop a publicly available database displaying this clone repository and providing a platform for correlation with other databases of chromosomal aberrations, as well as clinical and histopathological information."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15346] "A listing of genetic variations in genes important to cancer"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15347] "Collaborative and interdisciplinary genetic epidemiology investigations designed to identify and evaluate the interactions of genetic and epidemiologic risk factors leading to cancer susceptibility in individuals, families and populations, and factors influencing the rate of increase with age in cancer susceptibility. Emphasis on multi-site, cooperative research by multi- disciplinary teams of investigators wishing to collaborate within the common theme of the genetic epidemiology of cancer.  Particular emphasis is placed on encouraging interdisciplinary, population-based research focusing on the etiologic mechanisms underlying the interaction of genetic and epidemiologic risk factors for cancer susceptibility. The effect on cancer susceptibility of age-related changes over the lifespan, and the genetic factors leading to older age at onset of cancer are also of interest."                                                                               
[15348] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15349] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15350] "Similar to the human CGAP. The overall goals of the m-CGAP are: a comparative assessment of mouse cancer stages with those of cognate human cancers, both to validate the mouse models and to promote crossfeeding in the identification of genes that characterize those cancers; the discovery of new genes and gene pathways involved in the stages of carcinogenesis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15351] "A program to improve access to researchers testing new approaches to diagnosis, treatment and prevention in animal models of cancer.  Focus will be on functional, quantitative imaging.  (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15352] "This initiative will encourage applications that apply imaging technologies in the assessment of investigational cancer therapeutic agents. The proposed research projects will focus on the development and application of non-invasive tools for the functional or quantitative assessment of biochemical, genetic, or pharmacologic activity of specific therapeutic agents, or the defined biochemical pathway(s) in which they act. (from an RFA description)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15353] "A single national Network of investigators that will perform multi-institutional clinical trials in diagnostic imaging related to cancer. The Network will have the capability to conduct a broad spectrum of clinical trials in imaging. This Network will generate new trials in areas of high scientific opportunity.  The Network will consist of a Headquarters office that coordinates operations, a Biostatistics and Data Management Center (BDMC), and a number of participating institutions in which the studies are performed.  Participating institutions will be selected by the Network's scientific leadership for their ability to contribute to the particular trials in the Network's research repertoire."                                                                                                                                                                                                                                                                      
[15354] "This initiative is intended to advance the state-of-the-art in digital mammography displays and workstation design to facilitate clinical acceptance and implementation of digital mammography for improved breast cancer diagnosis. This PA will solicit research and development in three critical areas in digital mammography: 1) Softcopy Display Hardware; 2) Workstation Software and Design; and 3) Image Perception."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15355] "Catalog of genes expressed in cells at various stages of tumor development.  hGTI is part of CGAP. (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15356] "The concept of the Center was to have a facility whereby individuals (geneticists, cell biologists, and laboratory-based clinicians) could assemble in an arena to review technologies that are mature enough to span both science and clinics. One section of the ATC is the genome's National Institutes Sequencing Center (NISC) where the NCI sequencing and genotyping group will be located, and another part is the array facility."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15357] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15358] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15359] "Cooperative family registries specific for breast and colorectal cancer studies"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15360] "NCI initiate to explore, develop and then apply technology for identification and characterization of genes important in cancer.  Based on gene discovery program in CGAP, the GAI is currently exploring the application of multiple technological approaches to searching the 3'UTR of genes for sequence variation.  Once identified and confirmed, these variants will be put into public databases maintained by NCIBI's dbSNP and CGAP web resources.  See also Cancer Genome Anatomy Project."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15361] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15362] "Use of nucleotide analogs in cancer treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15363] "Research on the molecular, genetic, biochemical, cellular, structural, immunological, pharmacological mechanisms and factors as they relate to the causation, progression, diagnosis, and treatment of breast cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15364] "Assay conducted in an artificial environment, such as in a test tube, under a defined and controlled set of solvent and solute conditions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15365] "In vitro experiments conducted with intact, living cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15366] "Examination of the blood from a group of usually asymptomatic individuals to detect those with a high probability of having a given disease, typically by means of inexpensive diagnostic tests."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15367] "Process of restoring the ability to live and work as normally as possible after a disabling injury or illness including physical, speech, and occupational therapy. (OMS94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15368] "Research on tumor-infiltrating lymphocytes and their use as a cancer treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15369] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15370] "The scientific disciplines concerned with the embryology, anatomy, physiology, biochemistry, pharmacology, etc., of the nervous system. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15371] "RAEB:Used for projects involving any aspect of diet or dietary components or contaminants; or food production, packaging, storage, or preparation in relation to health effects, whether positive or negative. Dietary components include drinking water, alcoholic beverages, and vitamin and trace element supplements. Nutrition studies will usually be in the carcinogenesis, prevention, or epidemiology programs but occasionally are associated with treatment or rehabilitation. The latter two areas may be concerned with taste, anorexia, cachexia, and difficulties in chewing or swallowing."                                                                                                                                                                                                                                                                                                                                                                                         
[15372] "RAEB: Use for studies involving not only vitamins other than A,B,C or E, but its precursors and analogs as well. These studies can involve dietary epidemiology, prevention, therapy, or any other relationship of the vitamin to cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15373] "A group of parameters commonly investigated during preclinical drug development."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15374] "Linscott's Directory of Immunological and Biological Reagents.  No other source in the world tells you where to buy more than 54,000 different products used in Biomedical Research.: View Contents Linscott's Directory of Immunological and Biological Reagents New Macintosh Edition available September 19, at http://ourworld.compuserve.com/homepages/LINSCOTTSDIRECTORY/"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15375] "Research emphasis areas are medical and scientific research topics that warrant expanded support based on scientific need and opportunity, public health importance, and/or legislative mandate.  These emphasis areas are developed jointly with the scientific, medical, and public health communities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15376] "An NIH Emphasis area"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15377] "Integrated program having an objective of reducing risk, incidence, and mortality from cancer and to enhancing the quality of life for cancer survivors. Realized through an orderly sequence of measures from genetic, epidemiologic, behavioral, social, applied, and surveillance cancer research to the development and implementation of effective interventions, and monitor and analysis of cancer trends in all segments of the population."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15378] "RAEB: use of biological agents to enhance the host immune system in cancer"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15379] "Semisynthetic conjugates of various toxic molecules, including radioactive isotopes and bacterial or plant toxins, with specific immune substances such as immunoglobulins, monoclonal antibodies, and antigens. The antitumor or antiviral immune substance carries the toxin to the tumor or infected cell where the toxin exerts its poisonous effect. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15380] "Biological cancer immunology is the use of biological agents to enhance the host immune system in treatment of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15381] "Chemical Cancer Immunotherapy is the use of chemical substances to alter the interaction between the host's immune defenses and cancer cells to boost, direct, or restore the body's ability to fight cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15382] "A component of CGAP."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15383] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15384] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15385] "Minimally invasive procedure for ablating tumors.  The primary mechanism of tissue damage is thermal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15386] "The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by scintillation counting."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15387] "Treatment designed to improve the health of a chemotherapy patient but that does not directly affect the tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15388] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15389] "Pharmacological and behavioral interventions, such as the combined use of nicotine replacement and biofeedback, for the treatment of physiological addictions, such as nicotine. (NCI/TRIP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15390] "Studies identifying, testing, and implementing interventions among groups of individuals that are designed to both prevent and stop current use of specific substances, such as tobacco or alcohol. (NCI/TRIP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15391] "Research Studies that assess the behavioral and/or pharmacological treatment of individuals for nicotine dependence/addiction.  The specific focus of treatment interventions is the individual in clinical and physician-based settings. (NCI/TRIP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15392] "Identification and testing of pharmacological interventions, such as nicotine replacement, specifically for the treatment of a physiological addiction, i.e., nicotine. (NCI/TRIP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15393] "Research studies that assess trends in tobacco-related risk factors, behaviors and health services to determine changes over time and the influence of these trends on cancer incidence, morbidity, mortality and survival.  (NCI/TRIP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15394] "Laboratory-based research studies that assess the effects of tobacco and tobacco products on cell biology and cellular mechanisms of action, including the role of tobacco and tobacco byproducts in the initiation and promotion of cancer and the biological.  (NCI/TRIP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15395] "Studies that assess the administration of specific and/or dietary modifications to reverse or suppress the carcinogenic effects of tobacco and prevent the development of invasive cancer.  (NCI/TRIP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15396] "Research studies that test group and population-based interventions and the dissemination of group and population-based interventions to prevent and reduce tobacco use. (NCI/TRIP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15397] "Studies to test and implement interventions among groups of individuals that are designed to stop current use of tobacco.  (NCI/TRIP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15398] "Studies to test and implement interventions among groups of individuals that are designed to both prevent the initiation of tobacco use and stop current tobacco use.  (NCI/TRIP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15399] "Research studies that assess the effect of policies, including worksite, community, state and Federal policies, on tobacco initiation and use. (NCI/TRIP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15400] "Assesses basic principles of behavior, including basic laboratory research as well as research directed at individuals. (DCCPS)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15401] "Studies assessing the basic relationships between biological and behavioral factors and/or their potential relationship on prevention and/ or cessation interventions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15402] "Studies that develop and test specific interventions aimed at changing negative health behaviors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15403] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15404] "Minimal interventions directed at individuals that do not involve a health care provider, such as self-help and telephone counseling."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15405] "Research studies assessing the effect of policies, including worksite, community, state and Federal policies as related to a variety of health issues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15406] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15407] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15408] "Treat infections with antibacterial, antifungal, antiparasite or antiviral drugs"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15409] "The study of infectious diseases in the laboratory"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15410] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15411] "New physical or chemical means to treat disease"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15412] "Determining the antigens (whole virus, parts or crossreacting) to be incorporated in a vaccine"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15413] "A nationwide cancer information and education network sponsored by the NCI.  Provides information on prevention, treatment, and ongoing clinical trials to cancer patients and their families, people at risk for cancer, and health professionals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15414] "NCI-sponsored program that promotes and supports clinical trials in cancer treatment, (largely combined modality approaches); cancer prevention, and early detection within setting of a Cooperative Group."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15415] "As the drug discovery and development arm of the National Cancer Institute, the Developmental Therapeutics Program (DTP) plans, conducts, and facilitates development of therapeutic agents for cancer and AIDS.  They are a resource for research materials, including Web-accessible data and tools, vialed and plated compounds, tumor cells, animals, and Investigational New Drug (IND)-directed studies.  (DTP web site)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15416] "Office of International Activities sponsors two international scientist exchange programs: Short-Term Scientist Exchange Program and Oncology Research Faculty Development Program"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15417] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15418] "Study of artificial sweeteners as potential carcinogens and in relation to general health."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15419] "RAEB-2: Food components that function as free radical scavengers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15420] "RAEB-2: Role of caffeine in cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15421] "RAEB: Use for studies involving not only vitamin A, but its precursors and analogs as well. These studies can involve dietary epidemiology, prevention, therapy, or any other relationship of the vitamin to cancer"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15422] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15423] "RAEB-2: Role of dietary selenium in cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15424] "Role of dietary patterns, foods, and nutrients or other dietary components in cancer incidence and prevention."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15425] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15426] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15427] "RAEB: Any method for determining as accurately as possible total food amount and composition ingested by subjects in dietary studies or amount of specific dietary components."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15428] "A.D.E.P.T.  A systemic therapy which ensures that a specific prodrug is not converted into the active moiety anywhere but at the sites where the enzyme-linked, tumor-specific antibodies have localized."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15429] "A shared facility for creation and propagation of transgenic mice."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15430] "A shared facility which maintains a breeding stock of animals in a disease-free state."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15431] "A shared facility which provides services for DNA sequencing"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15432] "Treatment modality used to increase the delivery of chemotherapeutic agents and monoclonal antibodies to the central nervous system tissue through temporal disruption of blood brain barrier, the specialized system of microvascular endothelial cells that via both physical (tight junctions) and metabolic (enzymes) mechanisms limits transport of various chemical compounds, radioactive ions, and disease-causing organisms to brain parenchyma thereby maintaining the proper conditions for normal brain function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15433] "A shared facility which usually provides services for DNA and RNA isolation and DNA cloning and sequencing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15434] "A shared facility which provides services for oligonucleotide synthesis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15435] "Heating of tumors to the 40.5-42.5C range. Increases the oxygenation of tumors thereby enhancing the effect of radiation therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15436] "Increases the oxygenation of tumors thereby enhancing the effect of radiation therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15437] "Treatment given at the time of an operation to augment the effects of the operation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15438] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15439] "Monitoring a person's health over time after treatment.  This includes keeping track of the health of people who participate in a clinical study or clinical trial for a period of time, both during the study and after the study ends."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15440] "Establishment of a self replicating population of stem cells with subsequent repopulation of differentiated cell types."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15441] "A process by which a dose of radiation is automatically shaped to closely conform to the entire volume of the tumor, so that surrounding normal tissue is spared and treatment toxicity is decreased. (from Varian Oncology web site)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15442] "A core facility for preparation and analysis of histopathology samples."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15443] "A core facility for the preparation and synthesis of organic molecules."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15444] "Basic research to understand the mechanisms that cells use to avoid being killed by cytotoxic drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15445] "The transference of stem cells within the same individual."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15446] "The study of cell surface markers on tumor cells which can be recognized by antibodies, and the development of diagnostic reagents or therapuetic strategies which rely upon immune recognition."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15447] "Studies which are secondary to another study."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15448] "Methods to avoid amputation of an arm or leg"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15449] "A shared facility which provides services for electron microscopy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15450] "A shared facility providing biostatistical services."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15451] "Investigations into the link between food choices and disease.  Similar to dietary history."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15452] "(1) Plans and coordinates the development; (2) coordinates the clinical testing of new approaches in academia, industry, or in other parts of the federal government; (3) coordinates the development targeted to specific biochemical or physiological processes in cancer cells for better biologic insight into the physiology of human tumors; (4) encourages industrial commitment to the development and ultimate clinical testing relevant to cancer; (5) coordinates activities with other programs of the Institute, other federal agencies, and outside organizations; (6) coordinates the activities of the branches within the Program for productive interactions and effective technology transfer; and (7) assesses the activities of the Program and advises the Division Director regarding scientific opportunities for the development of new approaches to the diagnosis and treatment of cancer. (From http://www.nci.nih.gov/oma/HNCB8.htm)"                                  
[15453] "Introduction, application, and evaluation of effective and practical cancer prevention, control, and rehabilitation intervention programs in community settings."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15454] "Sources of information such as libraries, databases, and websites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15455] "[Therapeutic implications] Research in radiotherapy using ionizing and non-ionizing radiation and those areas in radiobiology and radiation physics that relate to radiation therapy, including laboratory investigations at the molecular, cellular, tissue, and whole animal levels. (DEA-CAACT)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15456] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15457] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15458] "RAEB: Any intervention to help breast cancer patients overcome the physical or psychological effects of their disease or its treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15459] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15460] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15461] "Physical map of the human genome"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15462] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15463] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15464] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15465] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15466] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15467] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15468] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15469] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15470] "A measure of the incidence of cancer within the population and an estimate of the financial, emotional, or social impact it creates. The burden of disease is not borne equally by all population groups in the United State."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15471] "The Surveillance Research Program (SRP) directs a program of cancer surveillance involving the collection and analysis of pertinent data in order to answer key questions about cancer incidence, morbidity, mortality, and cancer-related health status in diverse regions and in general and specific populations of the U.S. defined by sociodemographic measures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15472] "A visual representation of the national cancer burden.  These maps display cancer mortality data by county and state economic regions across the country.  They are color coded to distinguish between regions with high, intermediate, and low rates of cancer mortality."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15473] "A study designed to investigate the significance of social, behavioral, lifestyle, biological, treatment, and health care factors to the observed differences in cancer survival among African-Americans and white Americans. Data have been collected on more than 3,400 patients with cancers of the breast, colon, uterus, and bladder. This group will be followed until 1996 to characterize survival differences. (from NCI CancerNet)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15474] "Surveillance projects which focus on issues of cancer"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15475] "Part of the National Surgical Adjuvant Breast and Bowel Project, the Breast Cancer Prevention Trial (BCPT) was a clinical trial designed to see whether taking the drug tamoxifen would prevent breast cancer in women who are at an increased risk of developing the disease. The BCPT also looked at whether taking tamoxifen would decrease the number of heart attacks and reduce the number of bone fractures in these women. The study began recruiting participants in April 1992 and closed enrollment in September 1997."                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15476] "A phase III, randomized, placebo-controlled cancer prevention trial of >18,000 men coordinated by the Southwest Oncology Group.  The trial will determine the effect of a daily dose of finasteride taken for seven years on the biopsy-proven prevalence of prostate cancer.  It is scheduled to be completed in 2004."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15477] "Evaluates new pharmacologic agents and methods of behavior modification."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15478] "A study designed to determine the best way to manage cases in which Pap smears return the mild cervical abnormalities of atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesions (LSIL)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15479] "The goal of the network is to evaluate biochemical, immunologic, genetic, and other quantifiable markers for diagnosis and prognosis of urinary bladder cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15480] "A system designed to ensure adequate representation of minority groups in clinical trials."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15481] "Traditional methods for evaluating treatment outcome focus on disease state.  Patient-Focused Outcomes places a greater emphasis on quality of life issues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15482] "An NCI-funded multi-institution project designed to better understand late effects of cancer upon cancer survivors"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15483] "Mandated by the FDA Modernization Act of 1997.  An NIH-wide database of information about federally and privately funded clinical trials regarding serious or life-threatening diseases or conditions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15484] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15485] "Surgery using a scalpel.  As opposed to laser surgery, cryosurgery, etc"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15486] "Postoperative care of surgery patients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15487] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15488] "Strategies and technologies for molecular phenotyping and biological marker discovery to improve understanding of disease and aid the pharmaceutical industry's ability to develop new therapeutic products efficiently and cost effectively. (from http://www.surromed.com/CorporateOverview.html)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15489] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15490] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15491] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15492] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15493] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15494] "Research areas of exceptional promise in the cancer field.  To qualify as extraordinary opportunities these research initiatives must: Respond to important recent developments in knowledge and technology; Offer approaches to cancer research beyond the size, scope, and funding of our current research activities; Be implemented with specific, defined investments; Be described in terms of achievable milestones, with clear consequences for not investing; and Promise advances for making progress against all cancers. (from 2001 Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15495] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15496] "Challenge to research community to revolutionize the classification of human tumors, away from classification based on morphology, toward a more clinically predictive and useful classification system based on molecular characterization of tumors.  (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15497] "Goal: to develop a comprehensive imaging research program to fit the development of imaging technology with medical needs to create a system to evaluate new imaging technologies rapidly and effectively. (NCI Web)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15498] "Goal: refine current models, create models that more closely parallel human cancers, devise efficient procedures that will make models available to all researchers who need them. (NCI Web)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15499] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15500] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15501] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15502] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15503] "The Community Clinical Oncology Program (CCOP) was established by the National Cancer Institute (NCI) in 1983. Through this program, community physicians work with scientists conducting NCI-supported clinical trials."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15504] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15505] "Provides researchers with access to approximately 8,000 cases of formalin-fixed, paraffin-embedded primary breast cancer specimens, with associated clinical data.  The collection is particularly well-suited for validation studies of diagnostic and prognostic markers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15506] "Studies designed to translate basic science findings into clinically useful tools.  Includes marker research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15507] "This HIV initiative will create a center for retrovirology research, with emphasis on basic and translational research related to viral evolution and resistance biology. Scientific issues to be addressed in solving the problem of HIV drug resistance will require the coordinated efforts of experts in structural biology and biochemistry, molecular and clinical or in vivo virology, epidemiology, and chemistry. The new program also will include animal model studies of population dynamics and population genetics of HIV, mathematical modeling of virus populations and evolution, and, ultimately, translation of the findings into drug development."                                                                                                                                                                                                                                                                                                                             
[15508] "Research conceived and conducted by scientists in laboratories and clinics across the country and at NCI.(2002 budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15509] "Research that takes place on the NCI campus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15510] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15511] "The Nurses' Health Study was begun in 1976 with the establishment of a cohort of 120,700 women aged 30-55 and was principally designed to assess risk factors for breast cancer. Cohort members initially resided in 11 geographically dispersed states representing the Northeast (Massachusetts, Connecticut, New York, New Jersey, Pennsylvania, Maryland), Northcentral (Ohio, Michigan), the West (California) and the South (Texas, Florida); although the majority of participants still reside in the original 11 states, members of the cohort currently live in all 50 states. These women report on exposures and disease outcomes every two years and follow-up in the cohort has been maintained at a level of better than 90% through 1990."                                                                                                                                                                                                                                          
[15512] "Study of monosaturated fats in relation to cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15513] "Methods of detection which do not require penetration of the body or body openings."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15515] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15516] "Part of the National Surgical Adjuvant Breast and Bowel Project.  A study to compare the efficacy of Tamoxifen to Raloxifene in prevention of primary breast cancer among women at high risk for the disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15517] "Study of polyunsaturated fats in relation to cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15518] "Elements of a personal medical history which are necessary to allow an individual to participate in a specific clinical trial."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15519] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15522] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15523] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15524] "Treatment of viral infections with antiviral medication"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15525] "All research into methods for treating viral infections."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15526] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15527] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15528] "RAEB: Biomaterial: Any natural or synthetic material designed or adapted to be compatible with biological systems (living tissue or cells) and used to replace, augment, or restore a tissue, organ, or function, or to release exogenous substances within the body. Examples include, but are not limited to, catheters, intraocular lenses, artificial joints, coral scaffolding for new bone growth, controlled release drug spheres, polymer lattices for genetically engineered cells.  NOT included are natural materials that are being used to perform their natural function, such as blood transfusions or organ transplants, or synthetic materials that have only transient or trivial interface with tissues (hypodermic needles, surgical instruments, minor wound dressings, etc.)"                                                                                                                                                                                                 
[15529] "RAEB: Clinical trial that is not therapeutic, preventive or diagnostic."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15531] "A treatment approved by FDA for treatment following surgery for melanoma patients who are at high risk of disease recurrence. (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15532] "Example: SEER and other cancer registries"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15533] "A study designed to conduct epidemiologic research on the role of environmental factors in the etiology of breast cancer in women who live in Nassau and Suffolk counties, New York. The US Congress has mandated the use of a case-control study and the Geographic Information System (GIS) database to study a list of environmental factors, including water quality, air pollution, electromagnetic fields, pesticides and other toxic chemicals, and hazardous and municipal waste. (from NIEHS Long Island Breast Cancer Study Project)"                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15534] "Every point of difference between premalignant or malignant cells and their normal counterparts is a potential target of opportunity for drug discovery - a molecular target of prevention or treatment. (Bypass Budget, 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15535] "Collection of small compounds (predominantly druglike organic substances synthesized using methods of combinatorial chemistry) used for screening for antineoplastic properties."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15536] "Collections of different molecules, often produced through combinatorial synthetic methods, used as a starting pool to screen against a desired pharmacological target."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15537] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15538] "From NCI Priorities Web page: Opportunities now exist to determine how variations in our genes combine with environmental factors to cause cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15539] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15540] "Studies of the links between biology and behavior aimed at identifying preexisting vulnerabilities to tobacco use.  By determining how these vulnerabilities interact with sociocultural and psychological influences on tobacco use, and by improving our ability to assess risks quantitatively, we can develop more effective prevention and cessation interventions and tailor these interventions to the people most likely to benefit from them. (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15541] "An advanced form of 3-Dimensional Conformal Radiation Therapy"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15542] "2B2; Risk Assessment and Prevention; Population-Based research: Natural History, Transmission, Risk Factors; Transmission; Natural History and Cofactors"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15543] "Multidisciplinary research aimed at addressing and modifying the excessive cancer incidence and/or mortality rates, the lower cancer survival rates, or the inadequate cancer prevention and control services for special populations.  The term \"special populations\" refers to those population segments that may experience, or are known to experience, high cancer rates and/or are underserved in terms of cancer prevention and control programs.  Special populations include Alaskan natives, American Indians, Hispanics, Asian- Americans, Blacks, blue-collar groups, the elderly, lower-income groups, native Hawaiians, and American Samoans. (DEA-CAACT)"                                                                                                                                                                                                                                                                                                                          
[15544] "From NCI Priority Web page: Identifying molecular differences between normal cells and cancer cells will enable us to develop a whole new generation of treatments and preventives that affect only cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15545] "Goal : to expand our understanding of tobacco addiction and the biological mechanisms underlying tobacco-induced cancers, develop ways to keep people of all ages from using tobacco, create interventions to prevent tobacco-related cancers in smokers and former smokers, and develop treatments for tobacco addiction and the cancers it causes. (from NCI Initiatives Web page)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15546] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15547] "Research as to the cause of pain and the treatment thereof"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15548] "Subcategory of Alternative Medical Systems in CAM. These systems of practice include areas acupuncture, acupressure, herbal applications, massage, diet, and exercises. These practices, especially in the form of Traditional Chinese Medicine have a prominent position in the U.S. Included are: Acupuncture, Herbal formulas, Diet, QiGong, Tai chi, Massage, manipulation, Acupotomy - Fibrosis, Fibromylogic electroacupuncturers used in China at Grant Wall Hospital. (NIH)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15549] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15550] "Drug therapy with two or more drugs given separately for a combined effect. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15551] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15552] "Involvement of the public health community (i.e., state and local health departments) in the development of initiatives and programs for cancer risk reduction, and cancer prevention and control.  Primary interest is in 1) research on interventions in cancer control in public health settings and 2) the dissemination and application of research findings among public health agencies and professionals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15553] "Elucidation and description of disease progress"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15554] "Elements of a personal medical history which would prevent an individual from participating in a specific clinical trial."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15555] "Indicates the progesterone receptor level measured in a primary tumor or in metastases. (>=10 is positive if measured in fmols/mg cytosol protein; Otherwise use institutional standards)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15556] "The estrogen receptor level measured in a primary tumor or in metastases.  There are essentially two distinct forms of breast cancer, one that tends to have an early onset and is characterized by an ER- status, and one that tends to have a late onset and is characterized by an ER+ status.  However, these two variants tend to overlap with respect to age, so it is possible for a young woman to have a \"late-onset\" form of breast cancer and for an older woman to have an \"early-onset\" variant of the disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15557] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15558] "Her2/Neu status defined at original diagnosis.  (NCI CDE Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15559] "Selected pre-treatment factors by which patients are segregated to assure equal balance of these factors before randomization to the intervention arms of a clinical protocol."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15560] "Status of progression through a sequential treatment protocol"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15561] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15562] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15563] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15564] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15565] "Number of prior chemotherapy regimens: If a patient has received a chemotherapy regimen, provide the number of different single or multi agent chemotherapy regimens the patient has received.  A regimen is described as a distinctive collection of agent(s) and/or modalities to be utilized together during a cycle or course of therapy.  A chemotherapy regimen may have been discontinued for any reason (e.g. completion of therapy, toxicity, disease progression).  If the planned treatment is ABVD/MOPP code as one chemotherapy regimen."                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15566] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15567] "A smoking cessation strategy recommended by the National Cancer Institute.  The first 'A' is to ask patients about their smoking status at every visit and record this information. The second 'A' is to advise smokers to quit. The third 'A' is to assist patients' cessation attempts where possible by helping them to set a quit date, providing self-help materials, prescribing pharmacological treatment, and recommending counseling. The final 'A' is to arrange follow-up contact. (from Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15568] "A method for nicotine replacement."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15569] "Investigated low fat, high fiber diets in preventing recurrence of colorectal polyps"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15570] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15571] "Drug therapy which targets retrovirus function by multiple mechanisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15572] "A study initiated in 1994 by researchers at the National Cancer Institute (NCI) to look at the impact that treatments for primary prostate cancer have on the quality of life of patients.  PCOS is the first systematic evaluation of health-related quality-of-life issues for prostate cancer patients conducted on a multiregional scale. (from NCI Press Release: http://rex.nci.nih.gov/massmedia/press releases/prost_outcome.html)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15573] "A vaccine consisting of synthetic glycoprotein 100 (gp100) melanoma antigen and incomplete Freund's adjuvant (IFA), an emulsifying agent and immune system stimulant, with antineoplastic activity.  Vaccination with gp100 human melanoma peptide vaccine with IFA stimulates the host immune system to direct cytotoxic T lymphocytes (CTL) against gp100 positive melanoma cells, resulting in decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15574] "Originally, therapeutic administration of serum or gamma globulin containing preformed antibodies produced by another individual; currently, immunotherapy includes nonspecific systemic stimulation, adjuvants, active specific immunotherapy, and adoptive immunotherapy.  New forms of immunotherapy include the use of monoclonal antibodies.  This approach has been widely adopted by cancer specialists, often in cases which fail to respond to other treatment.  Immunotherapy aims to boost immune system function, as with the administration of interferons and interleukin-2, or to attack cancerous cells directly, as with the injection of monoclonal antibodies.  Various immunotherapeutic techniques have also been employed among AIDS patients.  In addition, a number of alternative medical practices are claimed to enhance immune function, and various over-the-counter substances (e.g., goldenseal, lysine have gained popularity for this supposed property."          
[15575] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15576] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15577] "Previous chemotherapy administered as treatment for this cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15578] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15579] "A program of the CDC.  Established by an act of Congress in 1990 it provides for screening exams to underserved women."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15580] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15581] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15582] "Surveillance to improve the capacity to identify and understand emerging disparities in tobacco use, particularly among at risk youth. (from The NCI Strategic Plan to Reduce Health Disparities)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15583] "The overall goal is to understand the causes of health disparities in cancer and to develop effective interventions to eliminate these disparities. (from The NCI Strategic Plan to Reduce Health Disparities)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15584] "Centers for Population Health will be created to: 1) expand understanding of the social (e.g., income disparities, racial discrimination) and other causes of cancer-related health disparities, 2) develop new hypotheses for cancer control at social, institutional, and policy levels, and 3) develop, apply, evaluate, and disseminate interventions to improve population health. (from The NCI Strategic Plan to Reduce Health Disparities)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15585] "The Selenium and Vitamin E Efficacy Trial (SELECT) will provide more definitive evidence of the efficacy of these drugs in preventing prostate cancer. (from The NCI Strategic Plan to Reduce Health Disparities)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15586] "Surgery for rectal cancer involving precise removal of an intact mesorectal envelope with tumor-free margins.  Associated with local recurrence rates below 5% in clinical trials.  (from Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15587] "The mission of the CBRG is to engage basic and clinical scientists as well as epidemiologists and statisticians in a search for and validation of promising early cancer biomarkers. To do so, the CBRG supports and facilitates a broad spectrum of national and international research activities in molecular biology and genetics, particularly for the discovery of biomarkers for risk prediction and early detection of cancer. The CBRG also supports the development of databases and informatics systems to optimize tracking and assessment of biomarker utility and expression patterns. (from http://dcp.nci.nih.gov/cbrg/index.html)"                                                                                                                                                                                                                                                                                                                                                 
[15588] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15589] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15590] "Gel dosimetry involves filling a model of a body part, such as the head, neck or breast, with a gel mixture. The gel-filled model (phantom) then undergoes MRI, CT, ultrasound, or radiation therapy, to gauge how effective the same procedure might be for the patient. Radiation alters the chemical structure of the gel, and the changes appear when scientists view a cross-section of the phantom on the computer screen.  (from Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15591] "The use of imaging techniques to provide the basis for therapy. eg. commonly used for surgery, such tools enable surgeons to visualize internal structures through an automated overlay of 3D reconstructions of internal anatomy on top of live video views of a patient.  Also used for guidance of biopsy needles. (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15592] "A surgical procedure to treat and correct deformities, diseases, and injuries to the skeletal system, its articulations, and associated structures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15593] "Radiation treatment modality used as major component in treatment of primary and metastatic brain tumors. This is a standard treatment for multiple brain metastases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15594] "Application of electrical energy to electrosurgically vaporize or remove the obstructive enlarged prostatic tissue.  In electrosurgical vaporization, the electrode rapidly heats the tissue cells so that they turn into steam, leaving a space where the prostate tissue was previously present. (from Columbia University Department of Urology)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15595] "The NCI's Atlas of Cancer Mortality in the United States, 1950-94, shows the geographic patterns of cancer death rates in over 3,000 counties across the country over more than four decades. It contains the 254 color-coded maps (for about 40 cancers), that will make it easy for researchers and state health departments to identify places where high or low rates occur, and to uncover patterns of cancer that would escape notice if larger areas, such as states, were mapped. The atlas will not tell researchers why death rates are higher in certain localities than in others, but it will provide important clues for further in-depth studies into the causes and control of cancer. (from NCI press release http://rex.nci.nih.gov/massmedia/press releases/atlas.html)"                                                                                                                                                                                                         
[15596] "A funding project supporting research towards measuring the quality of cancer care in the United States.  It is to be a five-year project (starting which will support prospective cohort studies on 10,000 patients with newly diagnosed lung or colorectal cancers. The project is designed to increase the knowledge of the relationship between cancer care practices in the general population and patient outcomes including survival and quality of life. (http://healthservices.cancer.gov/cancors.html)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15597] "The new Tissue Array Research Program (TARP) is a collaborative effort between the National Human Genome Research Institute and NCI to continued advances in detection, diagnosis, and development of targeted cancer therapies.  Among its aims are: 1) Advance tissue microarray technology research and development, 2) Produce tissue microarrays for use by the research community, 3) Serve as an arraying facility for groups with unique tissue materials, such as clinical trial groups or consortiums of rare diseases, 4) Disseminate tissue microarray technology by providing training, workshops, establishing protocols and standards."                                                                                                                                                                                                                                                                                                                                              
[15598] "An investigational technique for lung cancer detection.  Looks for abnormal cell cytology in sputum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15599] "An alternative to traditional gene therapy, genoplasty is a repair technology that uses short DNA fragments to induce a cell to repair its genome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15600] "Short term endocrine therapy, prior to surgery, to \"down-stage\" primary breast cancer in order to increase the rate of breast-conserving surgery.  (from JMCC 7:557-562, 2000 via Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15601] "The ACSB provides qualified researchers with tissue, cell, blood and fluid specimens, as well as clinical data from patients with HIV-related malignancies.  The ACSB contains formalin-fixed paraffin embedded tissues, fresh frozen tissues, malignant cell suspensions, fine needle aspirates, and cell lines from patients with HIV-related malignancies. The bank also contains serum, plasma, urine, bone marrow, cervical and anal specimens, saliva, semen and multi-site autopsy tissues from patients with HIV-related malignancies including those who have participated in clinical trials. The bank has an associated database that contains prognostic, staging, outcome and treatment data on patients from whom tissues were obtained. (CancerNet)"                                                                                                                                                                                                                                 
[15602] "A collection of banked tumor specimens from large numbers of uniformly treated cancer patients with a variety of malignancies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15603] "An action or ministration that produces an effect or that is intended to alter the course of a pathologic process."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15604] "A NIGMS initiative to define the basic protein shapes and to catalog all proteins in terms of these shapes.  This project will require the determination of a large number (perhaps 10,000) of protein structures in a high throughput mode.  (from RFA: GM-99-009)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15605] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15607] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15608] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15609] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15610] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15611] "The actions of prevention, treatment, and management of illness and the preservation of mental and physical well-being through the services offered by the medical and allied health professions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15612] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15613] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15614] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15615] "RAEB: Any device, marker, or other means developed for the purpose of detecting the presence of a tumor early in its development, when it is theoretically more likely to be curable. Also education and promotion related to the benefits of early detection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15616] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15617] "Studies to develop and test interventions that are designed to prevent the initiation of tobacco use among individuals. (NCI/TRIP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15618] "Any intervention for management of a malignant neoplasm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15619] "General term for detecting and classifying cancer in patients. (from CSP94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15620] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15621] "Soft agar colony formation assay is performed to assay for anchorage independent growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15622] "Matirgel is considered as basement membrane and generated from EHS sarcoma. Matrigel contains not only basement membrane components (collagens, laminin, and proteoglycans) but also matrix degrading enzymes/their inhibitors and growth factors. Invasion of tumor cells into Matrigel has been used to characterize involvement of ECM receptors and matrix degrading enzymes which play roles in tumor progression. Matrix metalloproteinases (MMPs) are a family of enzymes known to degrade components of the extracellular matrix (ECM) and their activity and secretion have been implicated in tumor invasion. (from iProtocol, http://iprotocol.mit.edu/protocol/284.htm)"                                                                                                                                                                                                                                                                                                                
[15623] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15624] "A type of surgical prostatectomy which attempts to spare the nerves that control erection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15625] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15626] "Expressed Sequence Tags positioned in open reading frames."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15627] "Administration of a protein to compensate for the loss, as from disease or surgery, of a gland or tissue that would normally produce the protein."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15628] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15629] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15630] "Serial analysis of gene expression (SAGE) is novel method of assessing the variation in the type or amount of genes expressed in different tissues, at different times in development or in normal versus malignant cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15631] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15632] "Research into the combination of knowledge, practices, and attitudes that motivate the actions we take regarding health."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15633] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15634] "Light therapy using ultraviolet radiation between 320 to 400 nm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15635] "A group or series of case reports involving patients who were given similar treatment.  Reports of case series usually contain detailed information about the individual patients.  This includes demographic information (for example, age, gender, ethnic origin) and information on diagnosis, treatment, response to treatment, and follow-up after treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15636] "Cancer therapy using ionizing radiation to a significant (>50%) portion of the body, e.g. craniospinal, total body irradiation, or pelvic radiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15637] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15638] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15639] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15640] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15641] "The Ames test is a method in genetics to test the strength of a mutagen, that is, if an agent (for example, a chemical), causes mutations in living organisms. The test is named after its inventor, Bruce Ames.  The test works by taking bacteria that already have a single mutation, for example, a strain that cannot produce histidine, an amino acid that is essential for the bacterium to live. These bacteria are then exposed to the agent to be tested, and brought into an environment that is ideal for them to live and procreate, except it does not contain histidine. The more mutations the agent caused in the bacteria, the more likely it is for some of them to reverse the original mutation, that is, that the mutation occurs exactly in the right place to allow the bacteria to produce histidine again by themselves. The number of surviving bacteria colonies thus corresponds with the strength of the mutagen. (from Wikipedia)"                                   
[15642] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15643] "Validation; the act of validating; finding or testing the truth of something."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15644] "Predictive Value; an expression of the likelihood that a given test result correlates with the presence or absence of disease. (from On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15645] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15646] "Human Oncogene CSF1R (CSF1R/PDGFR family) encodes a type I transmembrane protein receptor tyrosine kinase for colony-stimulating factor-1, a local mediator that regulates survival, proliferation, and differentiation of hematopoietic cells.  The tyrosine residue at codon 969 is involved in negative regulatory activity, disrupted by amino acid substitutions.  Mutations at codon 301 lead to ligand independent constitutive receptor tyrosine kinase activity and neoplastic transformation.  Gene loss may support the pathogenesis of myeloid leukemia.  (from OMIM, SWISS-PROT, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                             
[15647] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15648] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15649] "Cripto is a novel, transforming gene of the epidermal growth factor family.  Cripto is an essential co-factor for Nodal family proteins, which are essential signaling molecules for mesoderm development.  Transcripts are detected only in undifferentiated cells and disappear after cell differentiation induced by retinoic acid treatment.  In mice, Cripto is required for germ-layer formation and the correct positioning of the anterior-posterior axis.  Prior to gastrulation, Cripto expression is initially symmetric and uniform in the epiblast, and then becomes asymmetric in a proximal-distal gradient."                                                                                                                                                                                                                                                                                                                                                                        
[15650] "Expressed in many peripheral tissues (high in placenta) by human HSD17B2 Gene (SDR Family), 387-aa 43-kDa Hydroxysteroid 17-Beta Dehydrogenase 2 is a potential type II membrane protein enzyme with an N-terminal type II signal-anchor motif and a C-terminal ER retention motif, likely associated with ER membranes, that uses NADH in the oxidative inactivation metabolism of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 also has 3-beta-HSD activity and 20-alpha-HSD activity toward 20-alpha-dihydroprogesterone. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15651] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15652] "(ah-KOOS-tik) Having to do with sound or hearing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15653] "diverse family of cytoskeletal proteins which bind actin, thereby stabilizing or destabilizing microfilaments, anchoring them to other cell structure, or subserving intracellular translocation and motility."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15654] "Actin is one of the most abundant proteins found in eukaryotic cells and is highly conserved throughout evolution. Monomeric actin, a slow ATPase composed of a 375 amino acid polypeptide chain, interacts with one molecule of ATP or ADP and contains one high affinity binding sites and various low affinity sites for divalent cations. Actin can quickly assemble into long polymer called microfilaments. In conjunction with myosin, actin is responsible for the contraction and relaxation of muscle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15655] "Class of enzymes that catalyze the transfer of acyl groups, most commonly a carboxylic acyl group."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15656] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15657] "Adenosine deaminase catalyzes the hydrolysis of adenosine to inosine. ADA deficiency causes one form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins.(LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15658] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15659] "A group of enzymes which catalyze the hydrolysis of ATP coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA. EC 3.6.1.3."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15660] "Adenylyl cyclases are membrane-associated enzymes that are expressed in most human tissues. These enzymes catalyze the formation of cAMP and are regulated by a family of G protein-coupled receptors, protein kinases, and calcium. Adenylyl cyclase is encoded by the ADCY9 gene and widely distributed. It is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. It may play a fundamental role in situations where fine interplay between intracellular Ca(2+) and cAMP determines the cellular function. It also may be a physiologically relevant docking site for calcineurin. (From LocusLink, Swiss_Prot and NCI)"                                                                                                                                                                                                                                                                                                              
[15661] "An individual between the ages of 13 and 19."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15662] "Adolescents; persons of age 13-17 (from PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15663] "A country in Southern Asia, north and west of Pakistan, east of Iran. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15664] "An age group comprised by people 65 years of age and older."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15665] "The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.  Any aspect of aging: molecular, physiological, epidemiological, programs targeted to older populations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15666] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15667] "A country in Southeastern Europe, bordering the Adriatic Sea and Ionian Sea, between Greece and Serbia and Montenegro. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15668] "Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15669] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15670] "A country in Northern Africa, bordering the Mediterranean Sea, between Morocco and Tunisia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15671] "A defined procedure for solving a problem.  Applied to a problem-solving procedure implemented in software to be executed by a computer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15672] "An enzyme that catalyses the cleavage of inorganic phosphate non-specifically from a wide variety of phosphate esters and having a high (greater than 8) pH optimum. (from On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15673] "Two or more genes are said to be alleles if they occupy the same DNA sequence at a locus on homologous chromosomes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15674] "Alpha-fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. (from LocusLink)"                                                                                                                                                                                            
[15675] "An emission of positively charged particles composed of two protons and two neutrons, i.e., helium nuclei, emitted during disintegration of very heavy isotopes; a beam of alpha particles or an alpha ray has very strong ionizing power, but weak penetrability."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15676] "Use of different exons in formation of a mRNA from initially identical transcripts. Can result in the generation of related proteins from one gene, often in a tissue or developmental stage specific manner."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15677] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15678] "The American Cancer Society (ACS) is a nationwide, community-based voluntary health organization, the largest private source of cancer research funds in the U.S. Headquartered in Atlanta, Georgia, the ACS has state divisions and more than 3,400 local offices. ACS provides information on cancer incidence, mortality, causes, manifestations, treatment, and prevention, as well as on cancer research and clinical trials, and promotes beneficial policies, laws, and regulations for patients and families affected by cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15679] "Native Americans; the indigenous people who lived in the Americas before European colonization."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15680] "(AM-il-aze) An enzyme that helps the body digest starches."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15681] "Amyloid protein is thought to be important for developing new synapses between nerve cells in the brain. It is normally produced in a 40-amino acid chain, which is soluble. But high levels of insoluble 42-amino acid chains have been found in the brains of Alzheimer's patients. It is these chains that clump together to form plaques."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15682] "The third phase of mitosis, in which the chromatids separate and migrate to opposite poles of the spindle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15683] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15684] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15685] "A country in Southwestern Europe, between France and Spain. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15686] "(AN-jee-o-gram) An x-ray of blood vessels; the person receives an injection of dye to outline the vessels on the x-ray."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15687] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15688] "A country in Southern Africa, bordering the South Atlantic Ocean, between Namibia and Democratic Republic of the Congo. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15689] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15690] "The branch of science concerned with origin and development of humans in all their physical, social, and cultural relationships."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15691] "(AN-tih-BOD-ee) A type of protein made by certain white blood cells in response to a foreign substance (antigen). Each antibody can bind to only a specific antigen. The purpose of this binding is to help destroy the antigen. Antibodies can work in several ways, depending on the nature of the antigen. Some antibodies destroy antigens directly. Others make it easier for white blood cells to destroy the antigen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15692] "An antibody directed against the individual antigenic determinants (idiotopes) on the variable region of an immunoglobulin molecule.  In principle an anti-idiotype antibody should inhibit a specific immune response and they are important to the regulation of the immune system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15693] "Strength of binding, usually of a small molecule with multiple binding sites by a larger, particularly the binding of a complex antigen by an antibody. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15694] "Antibody-dependent target cell killing by a killer cell.  An antibody is directed to the target by antigen-binding arms and anchors to the killer cell by an Fc receptor.  Antibody-mediated target cell destruction by non-sensitized effector cells.  The identity of the target cell varies, but it must possess surface IgG whose Fc portion is intact.  The effector \"killer\" cell possesses Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent."                                                                                                                                                                                                                                                                                                                                                                     
[15695] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15696] "CD4 Antigen, encoded by the CD4 gene, is a T-cell surface glycoprotein. CD4 has a role in cell-cell interactions and may act in signal transduction. CD4 is a accessory protein for MHC class-II antigen/T-cell receptor interaction and functions to initiate or augment the early phase of T-cell activation. CD4 enhances T-cell sensitivity to antigen and binds to LCK, which phosphorylates CD3-zeta. CD4 Antigen also serves as an HIV receptor, binding directly to the envelope protein gp120 on HIV. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15697] "antigens normally only seen at particular phases of differentiation of a cell type."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15698] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15699] "Islands between the Caribbean Sea and the North Atlantic Ocean, east-southeast of Puerto Rico. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15700] "The art or science of building; especially, the art of building houses, churches, bridges, and other structures, for the purposes of civil life"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15701] "A country in Southern South America, bordering the South Atlantic Ocean, between Chile and Uruguay. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15702] "A country in Southwestern Asia, east of Turkey. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15703] "Aromatase is the enzyme complex that catalyses the synthesis of estrogens from androgens, and therefore it has unique potential to influence the physiological balance between the sex steroid hormones. Both aromatase cytochrome P450 (P450arom; like plays a species-specific role for aromatase) and NADPH-cytochrome P450 reductase (reductase), the two essential components of the enzyme complex, are highly conserved among mammals and vertebrates. Aromatase expression occurs in the gonads and brain, and is essential for reproductive development and fertility. Of interest are the complex mechanisms involving alternative promoter utilization that have evolved to control tissue-specific expression in these tissues. (Reproduction (2001) 121, 685-695, Conley A. and Hinshelwood M.)"                                                                                                                                                                                       
[15704] "(ar-TEE-ree-AH-gra-fee) A procedure to x-ray arteries. The arteries can be seen because of an injection of a dye that outlines the vessels on an x-ray."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15705] "Artificial intelligence is the branch of computer science that deals with writing computer programs that can solve problems creatively."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15706] "Asian American; a person of asian, particularly east asian, ancestry who was either born in the United States or who was naturalized as a citizen of the United States."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15707] "The continent between the Indian Ocean and the South Pacific Ocean. The US State Department considers Ashmore and Cartier Islands and the Coral Sea Islands as a separate entities, each with its own code (AT and CR, respectively). (from CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15708] "A country in Central Europe, north of Italy and Slovenia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15709] "In immunology, a specific humoral or cell-mediated immune response against the body's own tissues.  An autoimmune process may produce or be caused by autoimmune disease.  Developmentally complex, not necessarily pathological, and possibly pervasive, cell or humoral immune system reactivity toward autologous (self) antigens; do not confuse with Autoimmune Disorder. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15710] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15711] "Award; a prize given for achievement in a specific area."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15712] "A country in Southwestern Asia, bordering the Caspian Sea, between Iran and Russia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15713] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15714] "[Non-therapeutic implications] Biological effects resulting from exposure to non-ionizing and ionizing radiation, particularly at low doses and dose rates, from both natural and man-made sources.  Investigations include molecular, cellular, tissue, and whole animal level, and the development of technologies to facilitate this research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15715] "Proteins that originated from bacteria sources."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15716] "The branch of science that studies bacteria, especially in relation to medicine and agriculture.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15717] "A chain of islands in the North Atlantic Ocean, southeast of Florida. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15718] "An archipelago in the Persian Gulf, east of Saudi Arabia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15719] "A country in Southern Asia, bordering the Bay of Bengal, between Burma and India. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15720] "An island between the Caribbean Sea and the North Atlantic Ocean, northeast of Venezuela. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15721] "An onco-protein generated from the fusion of Bcr and Abl genes by translocation process between chromosome 9 and 22 (Philadelphia chromosome), in CML (P210) and some ALL (P190)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15722] "Behavior; the actions or reactions of an object or organism, usually in relation to the environment or surrounding world of stimuli."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15723] "The study, prevention, and treatment of medical and psychosomatic disorders and of undesirable behaviors, such as overeating and substance abuse, by the application of behavior therapy techniques, such as biofeedback, relaxation training, and hypnosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15724] "Disciplines concerned with the study of human and animal behavior, such as psychology, sociology, and anthropology."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15725] "A country in Western Europe, bordering the North Sea, between France and the Netherlands. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15726] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15727] "A country in Central America, bordering the Caribbean Sea, between Guatemala and Mexico. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15728] "A country in Western Africa, bordering the North Atlantic Ocean, between Nigeria and Togo. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15729] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15730] "A type of globulin in plasma that in electrically charged solutions exhibits colloidal mobility between that of the alpha and gamma globulins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15731] "A country in Southern Asia, between China and India. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15732] "The study of the chemical substances and vital processes occurring in living organisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15733] "Any substance (other than a drug), synthetic or natural, that can be used as a system or part of a system that treats, augments, or replaces any tissue, organ, or function of the body. (Dorland, 28th ed, p199) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15734] "Implantable devices which convert biological energy (chemical energy of the metabolism of continuously regenerating body fluids or mechanical energy of periodic movements) to electrical energy. The sources include biogalvanic cells, biofuel cells, and ionic concentration cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15735] "A branch of applied ethics which studies the value implications of practices and developments in the life sciences. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15736] "(AS-say) A laboratory test to find and measure the amount of a specific substance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15737] "A diagnostic indication that disease may develop."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15738] "The study of the interrelationships of the biology and psychology in cognitive functioning, including intellectual, memory, and related neurocognitive processes. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15739] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15740] "science concerned with the phenomena of life and living organisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15741] "The study of the mechanics of a living body, especially of the forces exerted by muscles and gravity on the skeletal structure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15742] "Measurement of life; calculation of the probable duration of human life. (On-Line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15743] "A biologically inherent cyclic variation or recurrence of an event or state, such as the sleep cycle, circadian rhythms, or periodic diseases. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15744] "Biophysics; physics as applied to biological problems; an interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15745] "Any of a variety of types of biomolecular probes which measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15746] "RAEB: Biotechnology is the use of a biological system to carry out a synthetic or analytic function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15747] "African American; a term used in the United States to categorize people, most of whose ancestors were brought from Africa to the Americas as slaves between the sixteenth and nineteenth centuries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15748] "The movement of blood to and from the heart and to the rest of the body's organs, tissues, and cells through the network of arteries, veins, and capillaries. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15749] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15750] "A common molecular biology technique for detection of RNA molecules.  RNA extracted from a sample was denatured and separated by slab gel electrophoresis, then blotted on to a nitrocellulose or nylon sheet and hybridized with labeled DNA or RNA that is complementary to the desired RNA, whose presence is subsequently indicated by autoradiography or other visualization techniques."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15751] "A technique for detection of specific DNA fragments. Restriction fragments are separated by polyacrylamide-gel electrophoresis, blotted on to a plastic sheet (e.g. of nitrocellulose) and detected by hybridization with a radiolabelled probe followed by autoradiography. (from DM Glick: Glossary of Biochemistry and Molecular Biology (1996).)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15752] "Identification of proteins or peptides that have been separated by gel electrophoresis and transferred (blotted) to strips of nitrocellulose paper. The blots are then detected by enzymatically labelled or radiolabeled antibody probes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15753] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15754] "A country in Central South America, southwest of Brazil. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15755] "A volume made up of pages fastened along one edge and enclosed between protective covers. (from American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15756] "A country in Southeastern Europe, bordering the Adriatic Sea and Croatia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15757] "The taxonomy and biology of the multicellular, eukaryotic life forms of the kingdom Plantae. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15758] "A country in Southern Africa, north of South Africa. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15759] "A country in Eastern South America, bordering the Atlantic Ocean. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15760] "An archipelago in the Indian Ocean, about one-half the way from Africa to Indonesia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15761] "(bron-KOS-ko-pee) A procedure in which a thin, lighted tube is inserted through the nose or mouth. This allows examination of the inside of the trachea and bronchi (air passages that lead to the lung), as well as the lung. Bronchoscopy may be used to detect cancer or to perform some treatment procedures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15762] "A country in Southeastern Asia, bordering the South China Sea and Malaysia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15763] "A country in Southeastern Europe, bordering the Black Sea, between Romania and Turkey. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15764] "A country in Western Africa, north of Ghana. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15765] "A country in Southeastern Asia, bordering the Andaman Sea and the Bay of Bengal, between Bangladesh and Thailand. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15766] "A country in Central Africa, east of Democratic Republic of the Congo. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15767] "A country in Eastern Europe, east of Poland. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15768] "The cadherins are transmembrane glycoproteins involved in calcium dependent specific cell-cell adhesion through homophilic binding. They are crucial for morphogenesis and synapse formation, but also are involved in tumor invasion. The classical cadherins have five homologous extracellular domains and a cytosolic domain which binds through catenin to the cytoskeleton. The extracellular domains are immunoglobulin-like beta-sandwiches comprising usually 7 strands in the two sheets."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15769] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15770] "Calmodulin 1, encoded by the CALM1 gene, is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin 1 binds calcium and regulates proteins and enzymes in a calcium-dependent manner. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Ubiquitination strongly decreases its activity. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters. (From LocusLink, Swiss_Prot)"                                                                                                                                                                                                                                                                    
[15771] "Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases activated in response to a variety of extracellular stimuli and encoded by a multigene family. The MAPKs are part of complex protein kinase cascades. One of the several classes of MAPKs includes (among other ERKs) the extracellular signal-regulated kinases ERK1 (p44MAPK) and ERK2 (p42MAPK), activated by the RAF/MEK/ERK signaling pathway. ERK1/2 are widely involved in eukaryotic signal transduction. Upon activation, ERKs translocate to the nucleus and phosphorylate nuclear targets. Phosphorylated ERKs form essential dimers with phosphorylated and unphosphorylated ERK partners. Dimerization is part of the mechanism of MAP kinase family action. Mitogen-activated protein kinases (MAPKs) promote entry in the cell cycle.  (from OMIM 601795, 176948, Swiss-Prot P27361, P28482 and NCI)"                                                                                                 
[15772] "an intracellular, non-lysosomal enzyme."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15773] "A country in Southeastern Asia, bordering the Gulf of Thailand, between Thailand, Vietnam, and Laos. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15774] "A country in Western Africa, bordering the Bight of Biafra, between Equatorial Guinea and Nigeria. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15775] "A country in Northern North America, bordering the North Atlantic Ocean on the east, North Pacific Ocean on the west, and the Arctic Ocean on the north, north of the conterminous US. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15776] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15777] "A group of islands in the North Atlantic Ocean, west of Senegal. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15778] "protein shell which surrounds the virus nucleic acid; has icosahedral, helical, or complex symmetry."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15779] "cancer specific antigen of colon carcinoma, also present in adenocarinomas of endodermal origin and in human embryonic gastrointestinal tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15780] "Functions and activities of the cardiovascular system as a whole or of any of its parts. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15781] "Proteins that carry specific substances in the blood or across cell membranes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15782] "the catechol-O-methyltransferase (COMT) pathway is essential for preventing the generation of estrogen derived reactive oxygen species. (from Thorax 2000;55:574-578)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15783] "Cathepsin D, encoded by the CTSD Gene, is a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It has a specificity similar to but narrower than that of pepsin A, decomposing cytoplasmic proteins, cell organelles, collagen, elastase and proteoglycans. Cathepsin D takes part in angiogenesis and activates osteoclasts, and plays a major role in the destruction of bone tissue by cholesteatoma. Transcription of the CTSD gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast and ovarian cancer, and possibly Alzheimer disease. (From LocusLink, PMID 12185597 and NCI)"                                                                                                                                                               
[15784] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15785] "Etiology is the study of causation. In medicine it specifically refers to the causation of diseases or pathologies. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15786] "An island group in the Caribbean Sea, nearly one-half of the way from Cuba to Honduras. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15787] "The close adherence (bonding) to adjoining cell surfaces."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15788] "Diverse family of extracellular (e.g., laminin) and cell surface (e.g., NCAM) glycoproteins involved in cell-cell and cell-extracellular matrix adhesion, recognition, activation, and migration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15789] "The decreased cellular ability to proliferate with the passing of time.  Each cell is programmed for a certain number of cell divisions and at the end of that time proliferation halts.  The cell enters a quiescent state after which it experiences cell death via the process of apoptosis. (MSH98) The final stage of cellular differentiation, characterized by an inability to grow, divide, or repair damaged cell components, leading to cell death."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15790] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15791] "Animal or human cells that are grown in the laboratory."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15792] "The complex series of phenomena, occurring between the end of one cell division and the end of the next, by which cellular material is divided between daughter cells.  The cell cycle is an ordered set of events, culminating in cell growth and division into two daughter cells.  The stages of cell cycle includes G1-S-G2-M.  The G1 stage stands for \"GAP 1\".  The S stage stands for \"Synthesis\".  This is the stage when DNA replication occurs.  The G2 stage stands for \"GAP 2\".  The M stage stands for \"mitosis\", and is when nuclear (chromosomes separate) and cytoplasmic (cytokinesis) division occur."                                                                                                                                                                                                                                                                                                                                                                    
[15793] "The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15794] "Progressive restriction of the developmental potential and increasing specialization of function which takes place during the development of the embryo and leads to the formation of specialized cells, tissues, and organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15795] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15796] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15797] "The complex series of phenomena occurring after cell division and before cell death."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15798] "Cells of a single type that have been grown in the laboratory for several generations (cell divisions)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15799] "Any type of cell movement that involves translocation of the whole cell, or cell body, from one site to another; distinct from cell movements that only involve motility of cell processes (e.g., axons, microvilli, etc.). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15800] "Characteristics and physiological processes of cells from cell division to cell death. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15801] "Techniques and methods for separating cells (usually viable) based on a variety of criteria for separation, such as size or density, non-specific surface properties, or specific surface properties.  Examples include cell affinity chromatography and centrifugation using density gradients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15802] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15803] "The CDC serves as the national focus for developing and applying disease prevention and control, environmental health and health promotion and health education activities designed to improve the health of the people of the United States. The CDC is responsible for controlling the induction and spread of infectious diseases, and provides consultation and assistance to other nations and international agencies to assist in improving their disease prevention and control, environmental health, and health promotion activities. (from Department of Health and Human Services Omnibus Solicitation of the Public Health Service for SBIR)"                                                                                                                                                                                                                                                                                                                                           
[15804] "A country in Central Africa, north of Democratic Republic of the Congo. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15805] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15806] "A method of separating macromolecules by either their differential rate of sedimentation in a centrifugal gradient or their differential bouyancy in a density gradient. (from biology-text.com)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15807] "A country in Central Africa, south of Libya. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15808] "Chemical Engineering; engineering dealing with the industrial application of chemistry. (WWWebster Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15809] "The science of the composition, structure, properties, and reactions of matter, especially of atomic and molecular systems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15810] "The branch of chemistry that deals with the quantitative and qualitative identification of substances. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15811] "A field of chemistry which pertains to the study of inorganic compounds or ions in biological systems. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15812] "The department responsible for performing chemical and enzymatic analyses of body fluids and tissues. (from Handbook of Medical Informatics)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15813] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15814] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15815] "Chemistry that deals with the composition and preparation of substances used in treatment of patients or diagnostic studies. (Dorland, 27th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15816] "Physical Chemistry; the branch of chemistry dealing with the physical properties of chemical substances. Chemical thermodynamics, chemical kinetics , quantum chemistry, statistical mechanics, and spectroscopy are some areas of chemistry comprising the bulk of physical chemistry. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15817] "The characteristic movement or orientation of an organism or cell along a chemical concentration gradient either toward or away from the chemical stimulus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15818] "A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15819] "The psychological, emotional, and sexual abuse of a child, typically by a parent, stepparent, or parent surrogate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15820] "The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders in children. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15821] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15822] "A country in Southern South America, bordering the South Atlantic Ocean and South Pacific Ocean, between Argentina and Peru. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15823] "A country in Eastern Asia, bordering the East China Sea, Korea Bay, Yellow Sea, and South China Sea, between North Korea and Vietnam. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15824] "bacterial enzyme which detoxifies the antibiotic chloramphenicol the gene therefore confers chloramphenicol resistance, which can be used as a marker or selector in genetic transfection experiments."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15825] "(en-dah-SKAH-pik RET-ro-grade ko-LAN-jee-o-PAN-kree-a-TOG-ra-fee) ERCP. A procedure to x-ray the pancreatic duct, hepatic duct, common bile duct, duodenal papilla, and gallbladder. In this procedure, a thin, lighted tube (endoscope) is passed through the mouth and down into the first part of the small intestine (duodenum). A smaller tube (catheter) is then inserted through the endoscope into the bile and pancreatic ducts. A dye is injected through the catheter into the ducts, and an x-ray is taken."                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15826] "A technique for the separation of complex mixtures that relys on the differential affinities of substances for a gas or liquid mobile medium and for a stationary adsorbing medium through which they pass."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15827] "A chromatographic separation technique based on the ability of proteins to bind specific ligands reversibly."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15828] "Gel permeation or sieve chromatography.  Chromatography performed on porous gels that separate solutes on the basis of size: smaller solutes are included within the particles of the gel matrix more frequently than larger solutes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15829] "Frequently referred to simply as HPLC, this form of column chromatography is used frequently in biochemistry. The analyte is forced through a column by liquid at high pressure, which decreases the time the separated components remain on the stationary phase. Less time on the column then translates to narrower peaks in the resulting chromatogram and thence to better selectivity and sensitivity. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15830] "Chromatographic techniques in which the mobile phase is a liquid. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15831] "Chromogranins are acidic secretory glycoproteins with a widespread but specific distribution in neuroendocrine tissues. The chromogranin family is heterogenous, consisting of propeptides such as chromogranin-A, chromogranin-B and secretogranin II, which can either elicit an effect themselves, or serve as precursors to a large number of peptides, which are biologically more active."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15832] "Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15833] "assignment of a locus to a specific chromosome or determining the sequence of genes and their relative distance from one another on a chromosome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15834] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15835] "The study and practice of medicine by direct examination of the patient. (MSH2000)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15836] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15837] "Any of the techniques that produce identical individuals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15838] "The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15839] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15840] "A group of islands in the Indian Ocean, south of Indonesia, about halfway from Australia to Sri Lanka. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15841] "1. Generic term embracing the mental activities associated with thinking, learning, and memory. 2. Any process whereby one acquires knowledge."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15842] "A fibrous protein found in cartilage and other connective tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15843] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15844] "A country in Northern South America, bordering the Caribbean Sea, between Panama and Venezuela, and bordering the North Pacific Ocean, between Ecuador and Panama. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15845] "(ko-lun-AHS-ko-pee) An examination of the inside of the colon using a thin, lighted tube (called a colonoscope) inserted into the rectum. If abnormal areas are seen, tissue can be removed and examined under a microscope to determine whether disease is present."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15846] "(kul-PAHS-ko-pee) Examination of the vagina and cervix using a lighted magnifying instrument called a colposcope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15847] "the exchange of information between objects, people, or groups."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15848] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15849] "Community Health Centers (CHCs) are private, non-profit organizations that directly or indirectly (through contracts and cooperative agreements) provide primary health services and related services to residents of a defined geographic area that is medically undeserved. Community health centers have a three-fold mission. First, CHCs aim to improve access to care for low income, underserved, vulnerable populations. They are required to be located in medically-underserved rural and urban areas, and within those communities, they serve those with limited access to more mainstream health care. Second, CHCs provide a fully comprehensive range of primary care services, including \"enabling\" or support services. Third, they involve the community in both the management and governance of the center. (Johns Hopkins School of Hygiene and Public Health, http://www.jhsph.edu/hao/pcpc/whatchc.htm)"                                                                   
[15850] "Draws on social relationships and organizations to reach large populations through media and interpersonal strategies that deliver messages and mechanisms to reduce chronic diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15851] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15852] "The coexistence of two or more disease processes. (MedicineNet.com)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15853] "A group of islands in the Mozambique Channel, about two-thirds of the way between northern Madagascar and northern Mozambique. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15854] "The complement system is a complex system of serum proteins that interact in a cascade.  Many of the early components are serine proteases that activate each other sequentially. This complement system consists of three separate activation triggers: (1) Ab binding to a cell surface, (2) formation of immune complexes, and (3) a carbohydrate component of a microbe's cell membrane.  Along with this triggers, there are also two sets of mechanisms.  Both of these mechanisms, classical pathway and alternative or properdin pathway, make MAC (Membrane Attack Complex), which can lyse and destroy the cell."                                                                                                                                                                                                                                                                                                                                                                         
[15855] "The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15856] "In cancer treatment, a process used to plan radiation therapy so that the target area is precisely located and marked."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15857] "Systems composed of a computer or computers, peripheral equipment, such as disks, printers, and terminals, and telecommunications capabilities. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15858] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15859] "heading term for all computer related (hardware and software) terms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15860] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15861] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15862] "A country in Western Africa, bordering the South Atlantic Ocean, between Angola and Gabon. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15863] "A document explaining all relevant study information to assist the study volunteer in understanding the expectations and requirements of participation in a clinical trial. This document is presented to and signed by the study subject. (from centerwatch.com glossary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15864] "A group of islands in the South Pacific Ocean, about one-half of the way from Hawaii to New Zealand. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15865] "A country in Central America, bordering both the Caribbean Sea and the North Pacific Ocean, between Nicaragua and Panama. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15866] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15867] "RAEB: study of relationship between cost and benefit; cost-benefit analysis"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15868] "Encoded by human CKB Gene (ATP:Guanido Phosphotransferase Family), 381-aa 43-kDa cytoplasmic homodimer or heterodimer Creatine Kinase is a transferase involved in energy homeostasis that primarily catalyzes reversible formation of ATP and creatine from phosphocreatine. Important in muscle contraction, the reaction stores ATP energy as phosphocreatine. Three cytoplasmic isoenzymes have been identified in human tissues: MM from skeletal muscle, MB from myocardial tissue and BB from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                               
[15869] "A country in Southeastern Europe, bordering the Adriatic Sea, between Bosnia and Herzegovina and Slovenia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15870] "Preservation of cells, tissues, organs, or embryos by storage at low temperatures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15871] "RAEB: The branch of science that deals with the geometric description of crystals and their internal arrangement. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) (MSH99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15872] "An island between the Caribbean Sea and the North Atlantic Ocean, 150 km south of Key West, Florida. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15873] "The customary beliefs, social forms, and material traits of a racial, religious, or social group.  Also, the set of shared attitudes, values, goals, and practices that characterizes a company or corporation. (from Webster's Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15874] "Most cellular effects of cAMP are mediated through PKA by serine or threonine phosphorylation of target proteins. Human Protein Kinase A (cAMP Ser/Thr Protein Kinase Family) is an inactive tetrameric cytoplasmic holoenzyme composed of homo- or heterodimeric regulatory subunits associated with two catalytic subunits. cAMP causes dissociation of inactive holoenzyme into a cAMP-bound dimer of regulatory subunits and two free monomeric catalytic subunits that phosphorylate many cytoplasmic and nuclear substrates. In human, regulatory PRKAR1A, PRKAR1B, PRKAR2A, and PRKAR2B subunits and catalytic PRKACA, PRKACB, and PRKACG subunits have been identified. (NCI)"                                                                                                                                                                                                                                                                                                              
[15875] "An island in the Mediterranean Sea, south of Turkey. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15876] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15877] "(sist-OSS-ko-pee) Examination of the bladder and urethra using a thin, lighted instrument (called a cystoscope) inserted into the urethra. Tissue samples can be removed and examined under a microscope to determine whether disease is present."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15878] "Branch of histochemistry associated with the localization of cellular components by specific staining methods, as for example the localization of acid phosphatases by the Gomori method."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15879] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15880] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15881] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15882] "Cytogenetics is the study of chromosomes and the related disease states caused by numerical and structural chromosome abnormalities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15883] "A protein often found as a cell surface marker on tumor cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15884] "Process in which the cytoplasm of a cell is divided after nuclear division (mitosis) is complete.  (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15885] "Techniques for manipulation of cells and analysis of cell properties and subcellular features."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15886] "Cytology; the branch of biology that studies the structure and function of cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15887] "Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15888] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15889] "statistical characterization of human populations (or segments of human populations broken down by age or sex or income etc.)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15890] "A country in Northern Europe, bordering the Baltic Sea and the North Sea, on a peninsula north of Germany (Jutland); also includes two major islands (Sjaelland and Fyn). (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15891] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15892] "Deoxycytidine Kinase, encoded by the DCK gene, is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15893] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15894] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15895] "The field of biology which deals with the process of the growth and differentiation of an organism. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15896] "RAEB: Any method of tumor detection that involves obtaining an image of the tumor, as opposed to a biochemical test or direct observation as in biopsy, endoscopy, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15897] "The process or act of converting food into chemical substances that can be absorbed and assimilated."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15898] "An animal with a disease either the same as or like a disease in humans. Animal models are used to study the development and progression of diseases and to test new treatments before they are given to humans. Animals with transplanted human cancers or other tissues are called xenograft models."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15899] "The constitutional or inborn state disposing to a disease, group of diseases, or metabolic or structural anomaly."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15900] "A country in Eastern Africa, bordering the Gulf of Aden and the Red Sea, between Eritrea and Somalia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15901] "Drug- or radiation-induced injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15902] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15903] "Terminal deoxynucleotidyltransferase is a unique DNA polymerase that without template direction catalyzes the addition of deoxyribonucleotides onto the 3-prime-hydroxyl end of DNA primers. TDT catalyzes the insertion of nucleotides (N regions) at the V(H)-D and D-J(H) junctions of immunoglobulin genes. The enzyme is present in immature thymocytes, some bone marrow cells, transformed pre-B and pre-T cell lines, and leukemia cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15906] "DNA-dependent DNA polymerases found in bacteria, animal and plant cells.  During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template.  They also possess exonuclease activity and therefore function in DNA repair.  EC 2.7.7.7 (from MSH2000)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15907] "RAEB: Enzymatic restoration of DNA structure after chemical, radiation, or spontaneous damage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15908] "The process by which the two strands of a DNA double helix separate, allowing each strand to act as a template for the synthesis of a complementary strand by specific base pairing. Includes autonomous but not virus replication."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15910] "Encoded by human TOP1 Gene (TOPI Family), 765-aa 90.7-kD monomeric DNA Topoisomerase I catalyzes transient ATP-independent breaking/rejoining of DNA and controls DNA topology during transcription. DNA topoisomerases I and II relax negative and positive supercoils; TOP1 breaks single DNA strands, TOP2 breaks duplex DNA. Specifically inhibited by the antitumor plant alkaloid CPT, when TOP1 breaks the DNA backbone bond it forms a protein-DNA link (a tyrosyl oxygen joins to a DNA strand end phosphorus). (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                               
[15911] "A class of enzymes that utilizes the energy of ATP hydrolysis to unwind (unzipped) dsDNA. The enzyme participate in various of biological process including DNA repication, transcription and recombination."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15912] "diverse group of viral and genetic regulatory proteins which bind in a sequence-specific manner to DNA, and share common structural motifs such as the \"zinc-finger,\" \"helix-turn-helix,\" and \"leucine zipper.\""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15913] "An island between the Caribbean Sea and the North Atlantic Ocean, about one-half of the way from Puerto Rico to Trinidad and Tobago. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15914] "A country comprising the eastern two-thirds of the island of Hispaniola, between the Caribbean Sea and the North Atlantic Ocean, east of Haiti. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15915] "Decreased expression of some gene product."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15916] "The use of a drug for a reason other than which it was intended or in a manner or in quantities other than directed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15917] "Diminished or failed response of an organism, disease, or tissue to the intended effectiveness of a chemical or drug. Mechanisms, functions, activities, or processes exhibited by pathogens to withstand previously toxic drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15918] "A procedure that uses ultrasonic waves directed over the chest wall to obtain a graphic record of the heart's position, motion of the walls, or internal parts such as the valves."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15919] "RAEB: The branch of biology concerned with the total complex of interrelationships among living organisms, encompassing the relations of organisms to each other, to the environment, and to the entire energy balance within a given ecosystem.  (STED98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15920] "RAEB: Economics (Medical): The utilization, distribution, and consumption of health services and materials. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15921] "A country in Western South America, bordering the Pacific Ocean at the Equator, between Colombia and Peru. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15922] "Acquisition of knowledge as a result of instruction in a formal course of study. (MSH2000)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15923] "A country in Northern Africa, bordering the Mediterranean Sea, between Libya and the Gaza Strip. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15924] "The release of semen through the penis during orgasm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15925] "A country in Central America, bordering the North Pacific Ocean, between Guatemala and Honduras. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15926] "Electromagnetic Fields.  Pervasive man-made sources include television, radio, electric power transmission lines, and computer terminals. Potentially a health hazard"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15927] "A spectrometric method, based on measurement of electron spins and magnetic moments, for detecting and estimating free radicals in reactions and in biological systems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15928] "RAEB-2: One of the negatively charged subatomic particles that are distributed about the positive nucleus and with it constitute the atom; in mass they are estimated to be 1/1836.15 of a proton; when emitted from inside the nucleus of a radioactive substance, electrons are called beta particles. (from STED98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15929] "An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15932] "Analytical and separative technique in which molecules, particularly proteins or nucleic acids, are separated by their different electrophoretic mobilities in a hydrated gel. The gel suppresses convective mixing of the fluid phase through which the electrophoresis takes place and contributes molecular sieving. For proteins, commonly carried out in the presence of the anionic detergent sodium dodecylsulphate (SDS). SDS denatures proteins so that noncovalently associating sub unit polypeptides migrate independently and by binding to the proteins confers a net negative charge roughly proportional to the chain weight."                                                                                                                                                                                                                                                                                                                                                      
[15933] "That branch of physiology that is concerned with the electric phenomena associated with living bodies and involved in their functional activity. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15934] "removal of whole viable embryos or fetuses from one environment and transplantation into the same or new environment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15935] "Science of the origin and development of the organism from fertilization of the ovum to the end of the eighth week. Sometimes used to include all stages of the life cycle. (from STED98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15936] "Any study of the physiology or pathology of endocrine hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15937] "Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. Endosomes play a central role in endocytosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15938] "(EN-dah-skope) A thin, lighted tube used to look at tissues inside the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15939] "(en-DAHS-ko-pee) The use of a thin, lighted tube (called an endoscope) to examine the inside of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15940] "Any subcellular or molecular event, process, or condition concerned with storing and generating metabolic energy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15941] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15942] "Branch of applied psychology that emphasizes the study of machine design, the relationship between humans and machines, and the effects of machines on human behavior. Use a more specific term if possible. (PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15943] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15944] "The sum total of all the conditions and elements which make up the surroundings and influence the development and actions of an individual. (Dorland, 28th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15945] "exposure to potentially harmful chemical, physical or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, toxic chemicals, dust, lead, or pollution; do not confuse with DOSAGE."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15946] "An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15947] "A protein that speeds up chemical reactions in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15948] "Epidemiological methods involve sophisticated statistics and higher mathematics.  These methods allow epidemiologists to address issues like non-experimental studies of mechanistic questions in disease etiology, including studies of the impact of the social position of individuals in different social contexts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15949] "The study of the causes, incidence and distribution of disease in the population and its application for prevention or control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15950] "A country in Western Africa, bordering the Bight of Biafra, between Cameroon and Gabon; composed of a mainland portion and five inhabited islands. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15951] "A country in Eastern Africa, bordering the Red Sea, between Djibouti and Sudan. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15952] "The production of erythrocytes. In the human, in early embryonic life they are produced in the yolk sac; in the middle trimester, by the liver; in the third trimester and after birth, by the bone marrow exclusively. The maintenance in a normal individual of a remarkably constant erythrocyte count and erythrocyte mass in the peripheral blood implies the existence of an erythropoietic stimulus that under physiological conditions so regulates the rate of production of new erythrocytes as to balance the rate of normal destruction. (Guyton, Textbook of Medical Physiology, 8th ed, p356 & Miale, Laboratory Medicine Hematology, 6th ed, p17) Erythropoiesis is the formation and development of mature red blood cells (erythrocytes)."                                                                                                                                                                                                                                         
[15953] "(eh-sof-a-GAHS-ko-pee) Examination of the esophagus using a thin, lighted tube."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15954] "Encoded by Esterase Genes, Esterases catalyze hydrolysis of ester bonds to produce alcohol and acid reaction products. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15955] "A country in Eastern Europe, bordering the Baltic Sea and Gulf of Finland, between Latvia and Russia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15956] "A country in Eastern Africa, west of Somalia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15957] "A social group characterized by a distinctive social and cultural tradition maintained from generation to generation, a common history and origin and a sense of identification with the group; members of the group have distinctive features in their way of life, shared experiences and often a common genetic heritage; these features may be reflected in their experience of health and disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15958] "The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15960] "Activity that requires physical or mental exertion, especially when performed to develop or maintain fitness"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15961] "Cellular release of secretory products within membrane-limited vesicles or granules."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15963] "A clotting factor found in the serum.  It combines with tissue factor (factor III) to activate factor X in the clotting pathway."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15965] "Human von Willebrand factor, a 270 kD multimeric plasma glycoprotein, has functional binding domains to platelet glycoprotien Ib, glycoprotein Iib/IIIa, collagen and heparin. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabiliser for coagulation factor VIII.  It is expressed in endothelial cells, platelets, megakaryocytes and a number of tumors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15966] "An island group between the Norwegian Sea and the North Atlantic Ocean, about one-half of the way from Iceland to Norway. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[15967] "Fatty acid synthase (FAS) is a key metabolic enzyme catalyzing the synthesis of long-chain saturated fatty acids. It plays a central role in the production of surfactant in fetal lungs, in the supply of fatty components of milk, and in the conversion and storage of energy in liver and adipose tissue. Remarkably high levels of FAS expression are found in the majority of human epithelial cancers.  Experimental manipulation suggests a link between FAS overexpression and dysregulation of membrane composition and functioning in tumor cells. (from Biochem Biophys Res Commun 2003;302:898-903)"                                                                                                                                                                                                                                                                                                                                                                                   
[15968] "Eating habits and their role in human disease"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15969] "In zoology, denoting the sex that bears the young or the ovum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15970] "An iron protein complex, containing up to 23% iron, formed by the union of ferric iron with apoferritin; it is found in the intestinal mucosa, spleen, bone marrow, reticulocytes, and liver, and regulates iron storage and transport from the intestinal lumen to plasma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[15971] "(fer-TIL-i-tee) The ability to produce children."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15972] "The process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[15973] "It is a process whereby ova are fertilized by sperms from designated partner in Petri dish, and the zygote thus produced was then introduced into the uterus and allowed to develop to term.  A treatment for couples who have infertility conditions"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[15974] "Encoded as alternative isoforms by human FN1 Gene, 2386-aa 262.6-kD Fibronectin precursor is a sulfated disulfide bound glycoprotein with multiple type I, II, and III fibronectin domains. MSF FN70 is an isoform. Plasma (hepatocytes) and cellular (fibroblasts and epithelia) FN differ in activity. Cell surface cellular FN (di/multimeric) is deposited in the ECM. FN is involved in embryogenesis, cell adhesion, migration, and motility, opsonization, wound healing, coagulation, host defense, cell shape, and metastasis. It stimulates endocytosis and may promote clearance of C1q-coated immune complexes. FN binds cell surface integrin, C1q, collagen, fibrin, hyaluronic acid, heparin, FBLN1, and actin. Most cells depend on FN to bind collagen. Talin-1 may link FN/Integrin with the actin cytoskeleton. FN may promote contact inhibition. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                  
[15975] "An island group in the South Pacific Ocean, about two-thirds of the way from Hawaii to New Zealand. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[15976] "The process of passing a liquid or gas through a filter."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15977] "A country in Northern Europe, bordering the Baltic Sea, Gulf of Bothnia, and Gulf of Finland, between Sweden and Russia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[15978] "Flow cytometry is a technique for counting, examining and sorting microscopic particles suspended in a stream of fluid. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15979] "The property of emitting radiation while being irradiated. The radiation emitted is usually of longer wavelength than that incident or absorbed, e.g., a substance can be irradiated with invisible radiation and emit visible light. X-ray fluorescence is used in diagnosis. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15980] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15981] "(floor-AHS-ko-pee) An x-ray procedure that makes it possible to see internal organs in motion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15982] "The field of study concerned with the study of food-borne microorganisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[15983] "The industry concerned with processing, preparing, preserving, distributing, and serving of foods and beverages. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15984] "Forensic medicine.  medicine in its relations to law. (from On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[15985] "A country in Western Europe, bordering the Bay of Biscay and English Channel, between Belgium and Spain, southeast of the UK; bordering the Mediterranean Sea, between Italy and Spain. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[15986] "A country in Northern South America, bordering the North Atlantic Ocean, between Brazil and Suriname. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15987] "An archipelago in the South Pacific Ocean, about one-half of the way from South America to Australia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[15988] "Belongs to the family of EC 2.4.1 glycosyltransferases. The enzyme catalyzes the transfer o f fucose molecule from dinucleotide compound to another carbohydrate compound."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15989] "A country in Western Africa, bordering the Atlantic Ocean at the Equator, between Republic of the Congo and Equatorial Guinea. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15991] "A country in Western Africa, bordering the North Atlantic Ocean and Senegal. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[15992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15993] "Electronic instruments that produce photographs or cathode-ray tube images of the gamma-ray emissions from organs containing radionuclide tracers. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[15994] "A type of globulin in plasma that in electrically charged solutions exhibits slowest colloidal mobility after that of the alpha and beta globulins. All immunoglobulins belong to this group of serum protein."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[15995] "Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                       
[15996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[15997] "(gas-TRAHS-ko-pee) An examination of the inside of the stomach using a thin, lighted tube (called a gastroscope) passed through the mouth and esophagus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[15998] "A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[15999] "The total loss or absence of a gene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16000] "A chromosomal structural change resulting in the doubling of a section of the genome of prokaryotes and eukaryotes. The size of the duplicated segment may vary considerably. Duplications may be interchromosomal, with the duplicate segment incorporated into another chromosome, or intrachromosomal, with the duplicate region present in the same chromosome. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed) The production of a tandem repeat of a DNA sequence by unequal crossing over or by an accident of replication.  Inclusion of two copies of the same genetic material in a genome; an important step in diversification of genomes, as in the evolution of the (non-allelic) hemoglobin chains from a common ancestor."                                                                                                                                                                                                                                   
[16001] "The transcription of genetic information into a message and the subsequent translation into a functional protein."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16002] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16004] "Covalent DNA changes in cells during normal differentiation resulting in new sequences, expression, or gene products; this is a mechanism of binding site diversification for antibodies, certain receptors, and possibly other proteins.  The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.  This includes the ordered rearrangement of variable gene regions; especially, the rearrangement of antibody genes during the differentiation of B-lymphocytes and the rearrangement of T-cell antigen receptor genes."                                                                                                                                                                                                                                                                                                                                                                                                            
[16005] "A functional unit of heredity which occupies a specific position (locus) on a particular chromosome, is capable of reproducing itself exactly at each cell division, and directs the formation of an enzyme or other protein. The gene as a functional unit consists of a discrete segment of a giant DNA molecule containing the purine (adenine and guanine) and pyrimidine (cytosine and thymine) bases in the ordered and correct sequence that encodes a specific functional product (i.e., a protein or RNA molecule). Protein synthesis is mediated by molecules of messenger-RNA formed on the chromosome with the gene acting as template. The RNA then passes into the cytoplasm and becomes oriented on the ribosomes where it in turn acts as template to organize a chain of amino acids to form a peptide. Genes normally occur in pairs in all cells except gametes, as a consequence of the fact that all chromosomes are paired except the sex chromosomes (X and Y) of the male." 
[16006] "DNA sequences that form the coding region for the viral envelope (env) proteins in retroviruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16007] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16008] "Highly conserved DNA sequences which have been identified in specific gene transcripts ranging from those of Drosophila melanogaster to mouse and human. Homeobox genes function, in part, to generate DNA-binding proteins with an evolutionary conserved approximately 60-residue sequence (HOMEODOMAIN PROTEINS)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16009] "Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and in the I region in mice. Present peptides to CD4+ T cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16010] "Genetic loci in the vertebrate major histocompatibility complex which encode polymorphic characteristics not related to immune responsiveness or complement activity, e.g., B loci (chicken), DLA (dog), GPLA (guinea pig), H-2 (mouse), RT-1 (rat), HLA-A, -B, and -C class I genes of man. Present peptides to CD8+ T cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16011] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16012] "DNA sequences that form the coding region for the protein responsible for trans-activation of transcription (tat) in human immunodeficiency virus (HIV)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16013] "Genes of viral origin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16014] "RAEB: Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16015] "Alterations in DNA that may indicate an increased risk of developing a specific disease or disorder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16016] "general heading term for methods, procedures, and processes for the study of genetics, including RNA and DNA chemistry."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16017] "The branch of biology that deals with heredity, especially the mechanisms of hereditary transmission and the variation of inherited characteristics among similar or related organisms"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16018] "The study of the genetic factors of behavioral phenotypes such as eating or mating activity, substance abuse, social attitudes, violence, and mental abilities. (from online American Heritage Dictionary of the English Language)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16019] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16020] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16021] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16022] "The complete gene complement of an organism. It is contained in a set of chromosomes in eukaryotes, a single chromosome in bacteria, or a DNA or RNA molecule in viruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16023] "The total gene complement, about 3 billion base pairs of DNA, contained in the human chromosomes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16024] "The genetic constitution of an organism or cell, as distinct from its expressed features or phenotype."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16025] "Any entity that occupies a location.  It is usually used to refer to all of the continents and every country and area situated within but also includes generic locations of health care delivery. They are significant in epidemiologic studies and historical articles and for locating administrative units in education and the delivery of health care."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16026] "The science that deals with the earth and its life, especially the description of land, sea, and air and the distribution of plant and animal life, including man and his industries with reference to the mutual relations of these elements. (Webster, 3d ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16027] "A country in Southwestern Asia, bordering the Black Sea, between Turkey and Russia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16028] "The branch of medicine concerned with the physiological and pathological aspects of the aged, including the clinical problems of senescence and senility. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16029] "A country in Central Europe, bordering the Baltic Sea and the North Sea, between the Netherlands and Poland, south of Denmark. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16030] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16031] "A dependency in Southwestern Europe, bordering the Strait of Gibraltar, on the southern coast of Spain. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16032] "A group of 33 coral atolls in the Pacific Ocean, straddling the equator; the capital Tarawa is about one-half of the way from Hawaii to Australia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16033] "Encoded as 2 alternative isoforms by human housekeeping G6PD Gene (G6PD Family), 514-/560-aa 59-kDa homodimeric or homotetrameric cytosolic Glucose-6-Phosphate Dehydrogenase mainly produces NADPH, an electron donor to oxidizing agents and in biosynthetic reactions. G6PD deficiency may cause jaundice, hemolysis, or non-spherocytic hemolytic anemia. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16034] "A class of enzymes that catalyze the reaction of glutathione with an acceptor molecule (an arene oxide) to form an S-substituted glutathione; a key step in detoxification of many substances; start of the mercapturic acid pathway."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16035] "A protein that has sugar molecules attached to it."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16036] "The covalent chemical or post-translational biochemical addition of carbohydrate or glycosyl groups to peptides or proteins by glycosyl transferases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16037] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16038] "A country in Southern Europe, bordering the Aegean Sea, Ionian Sea, and the Mediterranean Sea, between Albania and Turkey. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16039] "An island between the Arctic Ocean and the North Atlantic Ocean, northeast of Canada. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16040] "An island between the Caribbean Sea and Atlantic Ocean, north of Trinidad and Tobago. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16041] "The process of growing; progressive development. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16042] "the process of embryo differentiation and maturation; includes the embryogenic cleavage stage and the early embryonic stage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16043] "nonEC; family of high energy phosphate hydrolases; unlike ATPases, which are mainly involved in bioenergetics, GTPases are mainly involved in biological signal transduction."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16044] "Islands in the eastern Caribbean Sea, southeast of Puerto Rico. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16045] "Island in the North Pacific Ocean, about three-quarters of the way from Hawaii to the Philippines. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16046] "Guanylate cyclase (GC) is an enzyme that converts GTP to the second messenger cyclic GMP (cGMP). There are two forms: plasma membrane GCs that are receptors for hormones, and intracellular soluble GCs that are activated by the gaseous second messenger nitric oxide (NO). EC 4.6.1.2"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16047] "A country in Central America, bordering the Caribbean Sea, between Honduras and Belize and bordering the North Pacific Ocean, between El Salvador and Mexico. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16048] "A country in Western Africa, bordering the North Atlantic Ocean, between Guinea-Bissau and Sierra Leone. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16049] "A country in Western Africa, bordering the North Atlantic Ocean, between Guinea and Senegal. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16050] "A country in Northern South America, bordering the North Atlantic Ocean, between Suriname and Venezuela. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16051] "Gynecology; the branch of medicine that deals with the diseases and hygiene of women."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16052] "The oncogene (v-ras-Ha or v-Ha-ras) of Harvey murine sarcoma virus (Ha-MuSV) encodes a transforming protein."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16053] "A country comprising the western one-third of the island of Hispaniola, between the Caribbean Sea and the North Atlantic Ocean, west of the Dominican Republic. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16054] "Groups with similar restrictions or lack or ability to perform physical or mental activities in a manner or within the range considered normal for a human being."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16055] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16056] "human attitudes and behaviors related to health; e.g., diet, exercise, care-seeking, substance avoidance, therapy compliance, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16057] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16058] "A program under the U.S. Social Security Administration that reimburses hospitals and physicians for medical care provided to qualifying people over 65 years old."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16059] "A person who is trained and licensed to give health care. Also, a place licensed to give health care. Doctors, nurses, hospitals, skilled nursing facilities, some assisted living facilities, and certain kinds of home health agencies are examples of health care providers. (Medicare Glossary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16060] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16061] "Decisions, usually developed by government policy makers, for determining present and future objectives pertaining to the health care system. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16062] "The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16063] "Hearing; the auditory faculty, the perception of sound by the ear."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16064] "Heat-shock proteins belong to a large group stress proteins, induced in response to environmental challenges and developmental transitions.  Involved in stress resistance and actin organization, synthesis of HSP27 is correlated with the acquisition of thermotolerance.  HSP27 belongs to the HSP20 family and shows sequence similarity to alpha-crystallins.  Cytoplasmic HSP27 associates with alpha- and beta-tubulin, and with interphase and mitotic microtubules.  HSP27 translocates to the nucleus during heat shock and is phosphorylated on exposure to PKC activators and heat shock.  (from OMIM 602195, Swiss-Prot P04792, and NCI)"                                                                                                                                                                                                                                                                                                                                             
[16065] "any of a group of proteins that are synthesized in response to hyperthermia, hypoxia, or other stresses and that are believed to enable cells to recover from these stresses, perhaps by enabling recovery of gene expression; occur in prokaryotes and eukaryotes, and at least some proteins are similar in vertebrates and invertebrates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16066] "Hematology; the branch of medicine that deals with the blood and blood-forming organs and the diseases thereof."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16067] "The formation and development of the various types of blood cells in general or unspecified. The formation of erythrocytes is ERYTHROPOIESIS, the formation of blood cells outside the bone marrow, as in the spleen, liver, and lymph nodes is HEMATOPOIESIS, EXTRAMEDULLARY. (From Dorland, 28th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16068] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16069] "The red respiratory protein of erythrocytes, consisting of approximately 3.8% heme and 96.2% globin (64.5 KD), which as oxyhemoglobin (HbO2) transports oxygen from the lungs to the tissues where the oxygen is readily released and HbO2 becomes Hb."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16070] "The High Mobility Group (HMG) proteins were originally isolated from mammalian cells, named according to their electrophoretic mobility in polyacrylamide gels, and were arbitrarily classed as a specific type of non-histone proteins based on the observation that they are ubiquitous to mammalian cells, that they share certain physical properties, and that they are associated with isolated chromatin. Those mammalian proteins considered to be Canonical HMG proteins are now subdivided into 3 superfamilies: the HMGB (formerly HMG-1/-2) family, the HMGN (formerly HMG-14/-17) family, and the HMGA (formerly HMG-I/Y/C) family.  Each HMG family has a characteristic functional sequence motif. (www.informatics.jax.org/mgihome/nomen/genefamilies/hmgfamily.shtml)"                                                                                                                                                                                                             
[16071] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16072] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16073] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16074] "The study of the structure of the cells and their arrangement to constitute tissues and, finally, the association among these to form organs.  In pathology, the microscopic process of identifying normal and abnormal morphologic characteristics in tissues, by employing various cytochemical and immunocytochemical stains."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16075] "Histone acetylation and deacetylation alternately exposes and occludes DNA to transcription factors. Histone deacetylation is catalyzed by the histone deacetylases.  There are at least 2 classes of HDACs, class I consisting of proteins homologous to yeast Rpd3 (e.g., HDAC1, HDAC2 , and HDAC3) and class II consisting of proteins homologous to yeast Hda1 (e.g., HDAC4 and HDAC6). (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16076] "Linker Histone H1 interacts with DNA between nucleosome units in mediating chromatin compaction into higher order structures. Histones are basic nuclear proteins responsible for the nucleosome structure of eukaryotic chromatin. Repeating nucleosome units contain two molecules each of core Histones H2A, H2B, H3, and H4 that form an octamer complex around which approximately 146 base pairs of DNA is wrapped. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16077] "Slightly lysine rich histone.  One of four histones assembled into a nucleosomal core octamer.  Various posttranslationally modified forms and variants exist.  Combines with histone H2B in a heterodimer; two H2A/H2B dimers are incorporated in the nucleosomal octamer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16078] "Arginine rich histone.  One of four histones assembled into a nucleosomal core octamer.  Various posttranslationally modified forms and variants exist.  Combines with histone H4 in a heterotetramer of composition (H3)2(H4)2; one tetramer is incorporated in the nucleosomal octamer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16079] "Arginine rich histone.  One of four histones assembled into a nucleosomal core octamer.  Various posttranslationally modified forms and variants exist.  Combines with histone H3 in a heterotetramer of composition (H3)2(H4)2; one tetramer is incorporated in the nucleosomal octamer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16080] "Major protein component of chromatin.  Highly conserved basic proteins, originally classified into classes based on the relative amounts of arginine and lysine in each protein.  The various classes are now termed H1, H2A, H2B, H3, and H4.  In chromatin, they are found in an octamer, containing two each of H2A, H2B, H3, and H4, complexed with DNA in nucleosomes.  The histones in the octamer complex are also known as the core histones.  The H1 class of histones, termed the linker histones, is loosely associated with the nucleosome."                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16081] "A substance produced by certain white blood cells in reaction to contact with HIV, the human immunodeficiency virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16082] "glycoprotein encoded by HIV envelope gene (env) with a molecular weight of 120,000; interaction between gp120 and CD4 on T-helper cells is involved in the recognition of the cells by HIV and the binding of HIV to those cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16083] "transmembrane glycoprotein encoded by HIV envelope gene (env) with a molecular weight of 41,000 daltons; anchors gp120 to the viral particle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16084] "Encoded by human HLA-A (A2 allele) Gene (HLA Family), HLA-A2 Antigen is a 365-aa 41-kD class I alpha heavy chain glycoprotein heterodimerized with 11.6-kD beta-2 microglobulin. HLA-A protein organization includes a signal peptide, extracellular alpha1, 2, and 3 domains (90-aa each), a transmembrane region, and a cytoplasmic tail. Polymorphic alpha1 and 2 domains determine peptide binding specificity. Ig-like alpha3 mediates CD8 binding on cytotoxic T-lymphocytes. In the immune response, HLA antigens mediate antigen presentation to TCR. HLA-A2 subtypes are associated with decreased risk of HIV-1 infection and increased frequency of early-onset Alzheimer disease.  (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                         
[16085] "Encoded by multiple HLA-DRA and HLA-DRB genes in a complex variable 5 cM region of MHC between HLA-B and -D, HLA-DR Antigens are Class II histocompatibility transmembrane glycoprotein heterodimers of alpha (heavy, 35-kD) and beta (light, 27-kD) chains. Located predominantly on B cells and macrophages, HLA-DR antigens function in antigen presentation to regulatory T cells in the immune response and in self/nonself discrimination. Invariant alpha and polymorphic beta chains have glycosylated N-termini, hydrophobic membrane regions, and hydrophilic C-termini. The heterodimer consists of 4 extracellular domains; invariant alpha-1, polymorphic N-terminal beta-1, and conserved Ig-like alpha-2 and beta-2. Alpha-1 and alpha-2 contain disulfide loops. Beta-1 contains 2 small variable regions. Alpha sequences have relatively simple structure; beta chains carry the major polymorphic determinants. (NCI)"                                                           
[16086] "HMGN2 enhances the transcriptional potential of chromatin when incorporated into nucleosomes during, but not after, chromatin assembly on replicating DNA. Two molecules of HMGN2 can bind to nucleosome cores, independently of the underlying DNA sequence, in a cooperative fashion to limit nucleosome mobility and stabilize the structure of the nucleosome core without stabilizing the higher order chromatin structure. By modifying the structure of nucleosomes, the proteins affect the local structure of the chromatin fiber leading to an increase in the rate of transcriptional elongation but not initiation. (Semin Cell Biol 1995 Aug;6(4):247-55)"                                                                                                                                                                                                                                                                                                                             
[16087] "A country in Central America, bordering the Caribbean Sea, between Guatemala and Nicaragua and bordering the North Pacific Ocean, between El Salvador and Nicaragua. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16088] "A special administrative region of China, bordering the South China Sea and China. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16089] "An institution that provides medical, surgical, or psychiatric care and treatment for the sick or the injured."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16090] "The interactions between two organisms, one of which lives at the expense of the other. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16091] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16092] "A country in Central Europe, northwest of Romania. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16093] "A tumor of hybrid cells used in the in vitro production of specific monoclonal antibodies; produced by fusion of an established tissue culture line of lymphocyte tumor cells (e.g., mouse plasmacytoma cells) and specific antibody-producing cells (e.g., splenocytes from specifically immunized mice); fusions are accomplished by use of polyethylene glycol or other methods."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16094] "Enzymes (EC class 3) cleaving substrates with addition of H2O at the point of cleavage; e.g., esterases, phosphatases, nucleases, peptidases. SYN hydrolyzing enzymes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16095] "A chemical reaction that uses water to break down a compound."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16096] "Cytoplasmic Hypoxanthine Phosphoribosyltransferases (Purine/Pyrimidine Phosphoribosyltransferase Family) catalyze the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate.  The enzyme is important in purine biosynthesis as well as central nervous system functions. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16097] "A country in Northern Europe, island between the Greenland Sea and the North Atlantic Ocean, northwest of the UK.  (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16098] "Adequacy of natural and acquired appropriately targeted resistance to internal and external antigens."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16099] "Those manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16100] "Immune processes mediated by antibodies"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16101] "Immunochemistry; the field of chemistry concerned with chemical processes in immunology (such as chemical studies of antigens and antibodies)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16102] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16103] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16104] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16105] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16106] "Immunoglobulin Light Chain Kappa is one of two Ig light chain types. Each Ig molecule is typically composed of two heavy chains and two light chains. Ig kappa light chains contain a variable and a constant region. Kappa light chains are encoded by multiple V, J, and C gene segments, which are separated in the genomes of cells undifferentiated with regard to antibody gene expression. Diversity in the kappa light chain V region arises during differentiation of an activated (kappa-type) antibody-producing B-cell from variable recombination of kappa V genes with kappa J genes and somatic point mutation, which plays a major role in antibody diversity. (from OMIM and NCI)"                                                                                                                                                                                                                                                                                                 
[16107] "Each antibody molecule is composed of two identical heavy chains and two identical light chains. Immunoglobulin Light Chain Lambda is one of two Ig light chain types. Lambda light chains are encoded by multiple V, J, and C gene segments, which are separated in the genome. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink, OMIM, and NCI)"                                                                                                                               
[16108] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16109] "Histochemical localization of immunoreactive substances using labeled antibodies as reagents. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16110] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16111] "Antigen aggregation with antibody, in the right ratios, to cause precipitation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16112] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16113] "The number of new cases of a disease diagnosed each year."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16114] "A country in Southern Asia, bordering the Arabian Sea and the Bay of Bengal, between Burma and Pakistan.  (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16115] "A country in Southeastern Asia, comprising the archipelago between the Indian Ocean and the Pacific Ocean.  (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16116] "Any disease or condition resulting in postnatal death before age 1 yr. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16117] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16118] "An infant during the first month after birth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16119] "For information to be useful, not only does it need to be made available at the right time to those who need it such as policy makers, program planners, and health professionals, and patients but it has to be in the right form.  Information Dissemination includes both research into means of information distribution and the actual distribution of information."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16120] "The field of knowledge, theory, and technology dealing with the collection of facts and figures, and the processes and methods involved in their manipulation, storage, dissemination, publication, and retrieval. It includes the fields of COMMUNICATION, PUBLISHING, LIBRARY SCIENCE and informatics. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16121] "A branch of computer or library science relating to the storage, locating, searching, and selecting, upon demand, relevant data on a given subject. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16122] "A process in which a person learns key facts about a clinical trial, including potential risks and benefits, before deciding whether or not to participate in a study.  Informed consent continues throughout the trial."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16123] "RAEB: Electromagnetic radiation with wavelengths in the 800 nm to range.  Lies beyond the red in the visible portion of the spectrum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16124] "A small device installed under the skin to administer a steady dose of drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16125] "A medical devise designed to deliver drugs to the lungs and respiratory passages."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16126] "Introduction of semen into the uterus or oviduct by other than natural means.  One of various assisted reproductive Technologies used to treat infertility.  Performed by intrauterine insemination with semen presented in one of various forms: whole ejaculate, split ejaculate using the first portion containing the greatest sperm density and motility, or washed semen samples. (Merck Manual 16 Ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16127] "As part of the National Academy of Science, The Institute of Medicine identifies, for study and analysis, important issues and problems that relate to health and medicine. The Institute initiates and conducts studies of national policy and planning for health care and health-related education and research; it also responds to requests from the federal government and other agencies for studies and advice."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16128] "A group of scientists, doctors, clergy, and consumers at each health care facility that participates in a clinical trial.  IRBs are designed to protect study participants.  They review and must approve the action plan for every clinical trial.  They check to see that the trial is well designed, does not involve undue risks, and includes safeguards for patients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16129] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16130] "Elevated serum levels of insulin-like growth factor-1 (IGF-1) may identify premenopausal women who are likely to develop breast cancer before age 50. (from Int J Cancer 2000;88:828-832 via Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16131] "Insulin-like growth factors I and II, also known as somatomedin C and somatomedin A, respectively, are single chain polypeptides which share an amino acid sequence homology of about 47% with insulin and about 31% with relaxin and with them comprise the insulin family of polypeptide growth factors. Their functions include mediation of growth hormone action, stimulation of growth of cultured cells, stimulation of the action of insulin, and involvement in development and growth. They appear to be autocrine regulators of cell proliferation."                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16132] "Coverage by contract whereby one part indemnifies or guarantees another against loss by a specified contingency. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16133] "Payment by a third-party payer in a sum equal to the amount expended by a health care provider or facility for health services rendered to an insured or program beneficiary. (From Facts on File Dictionary of Health Care Management, 1988) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16134] "A protein that is an integral membrane protein with a transmembrane region."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16135] "Integrins are transmembrane glycoprotein receptors that mediate cell-matrix or cell-cell adhesion, and transduce signals that regulate gene expression and cell growth.  They are heterodimeric molecules consisting of noncovalently linked alpha and beta subunits. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Both alpha and beta subunits display a cytoplasmic domain that interacts with the cytoskeleton (and possibly signaling molecules), a transmembrane region, and a large extracellular domain that interacts with the extracellular matrix. (from OMIM 147557)"                                                                                                                                                                                                                                                                                                                                           
[16136] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16137] "The interval between two successive cell divisions during which the chromosomes are not individually distinguishable. Interphase is considered the resting stage of the cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16138] "A conversation with an individual regarding his or her background and other personal and professional details, opinions on specific subjects posed by the interviewer, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16139] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16140] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16141] "A transmembrane pore that presents a hydrophilic channel for ions to cross a lipid bilayer down their electrochemical gradients.  Some degree of ion specificity is usually observed and typically a million ions per second may flow. Channels may be permanently open, like the potassium leak channel or they may be voltage gated, like the sodium channel or ligand gated like the acetylcholine receptor. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16142] "A country in the Middle East, bordering the Gulf of Oman, the Persian Gulf, and the Caspian Sea, between Iraq and Pakistan.  (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16143] "A country in the Middle East, bordering the Persian Gulf, between Iran and Kuwait. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16144] "A country in Western Europe, occupying five-sixths of the island of Ireland in the North Atlantic Ocean, west of Great Britain. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16145] "A type of gel electrophoresis in which charged molecules travel through a pH gradient.  The molecules will come to stop at the point where the net charge on the molecule is equal to that of the surrounding gel."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16146] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16147] "A country in the Middle East, bordering the Mediterranean Sea, between Egypt and Lebanon. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16148] "A country in Southern Europe, occupying a peninsula extending into the central Mediterranean Sea, northeast of Tunisia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16149] "A country in Western Africa, bordering the North Atlantic Ocean, between Ghana and Liberia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16150] "An island in the Caribbean Sea, south of Cuba. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16151] "A country in Eastern Asia, occupying an island chain between the North Pacific Ocean and the Sea of Japan, east of the Korean Peninsula. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16152] "A country in the Middle East, northwest of Saudi Arabia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16153] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16154] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16155] "Mapping of the full chromosome set of the nucleus of a cell. The chromosome characteristics of an individual or a cell line are usually presented as a systematized array of metaphase chromosomes from a photomicrograph of a single cell nucleus arranged in pairs in descending order of size and according to the position of the centromere. (From Stedman, 25th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16156] "A country in Eastern Africa, bordering the Indian Ocean, between Somalia and Tanzania. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16157] "The branch of dynamics that pertains to the turnover or rate of change of a specific factor (e.g., erythrocytes - erythrokinetics, leukocytes - leukokinetics, iron - ferrokinetics), commonly expressed as units of amount per unit time. (Dorland, 28th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16158] "A country in Central Asia, west of China. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16159] "The consideration of knowledge, attitude, or behavior as variables in disease processes such as incident, transmission, and control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16160] "A country in Eastern Asia, occupying the northern half of the Korean Peninsula, bordering the Korea Bay and the Sea of Japan, between China and South Korea. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16161] "A country in Eastern Asia, occupying the southern half of the Korean Peninsula, bordering the Sea of Japan and the Yellow Sea. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16162] "A country in the Middle East, bordering the Persian Gulf, between Iraq and Saudi Arabia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16163] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16164] "The lacZ gene is a popular reporter gene in transfection experiments because its product, b-galactosidase, is very stable, resistant to proteolytic degradation, and easily assayed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16165] "A family of basement membrane extracellular basement proteins. Each molecule is composed of 3 nonidentical chains which are arranged in a cross-shaped structure. There are at least 5 alpha, 4 beta, and 3 gamma laminin genes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16166] "A systematic means of communicating by the use of sounds or conventional symbols."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16167] "A country in Southeastern Asia, northeast of Thailand, west of Vietnam. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16168] "(LAIR-in-GOSS-kuh-pee) Examination of the larynx (voice box) with a mirror (indirect laryngoscopy) or with a laryngoscope (direct laryngoscopy)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16169] "(LAY-zer) A device that concentrates light into an intense, narrow beam used to cut or destroy tissue. It is used in microsurgery, photodynamic therapy, and for a variety of diagnostic purposes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16170] "A country in Eastern Europe, bordering the Baltic Sea, between Estonia and Lithuania. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16171] "A country in the Middle East, bordering the Mediterranean Sea, between Israel and Syria. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16172] "A complex molecule that has both protein and sugars. Lectins are able to bind to the outside of a cell and cause biochemical changes in it. Lectins are made by both animals and plants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16173] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16174] "A country in Southern Africa, an enclave of South Africa. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16175] "lethal dose (LD) - 50%. the median lethal dose.  the dose of a chemical or biologic preparation (e.g., a bacterial exotoxin or a suspension of bacteria) that is likely to cause death in 50% of the animals being tested; it varies in relation to the type of animal and the route of administration; (the absolute lethal dose is LD100, and minimal lethal dose is LD05)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16176] "Leukocyte Surface Antigen p150,95 has a unique alpha chain (CD11c) and shares a beta subunit (CD18) with two other members of the leukocyte adhesion molecule family.  The alpha subunit has an extracellular domain containing ten potential glycosylation sites, a transmembrane domain, and a short cytoplasmic tail.  It shows homology to alpha subunits of Platelet Glycoprotein IIb/IIIa, Vitronectin Receptor, and Fibronectin Receptor.  Receptors involved in cell-cell and cell-matrix interactions belong to a superfamily of integrin genes.  (from OMIM 151510 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                              
[16177] "Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (usually measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with mitomycin C or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens."                                                                                                                                                                                                                                                                                                                                                     
[16178] "A country in Western Africa, bordering the North Atlantic Ocean, between Cote d'Ivoire and Sierra Leone. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16179] "Study of the principles and practices of library administration and services. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16180] "A country in Northern Africa, bordering the Mediterranean Sea, between Egypt and Tunisia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16181] "A country in Central Europe, between Austria and Switzerland. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16182] "Lifestyle; a manner of living that reflects the person's values and attitudes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16183] "Major class of enzymes that catalyse the linking together of two molecules (EC class 6) for example DNA ligases that link two fragments of DNA by forming a phosphodiester bond. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16184] "The process of measuring the extent of crossovers between chromosomes as a gauge of the distance between genes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16185] "The occurrence of some genes together, more often than would be expected based upon their physical separation, presumably because the combination confers some selective advantage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16186] "A country in Eastern Europe, bordering the Baltic Sea, between Latvia and Russia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16187] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16188] "Care over an extended period, usually for a chronic condition or disability, requiring periodic, intermittent, or continuous care. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16189] "Any one of several enzymes that catalyze the bioluminescent reaction in certain marine crustaceans, fish, bacteria, and insects. The enzyme is a flavoprotein; it oxidizes LUCIFERINS to an electronically excited compound that emits energy in the form of light. The color of light emitted varies with the organism. The firefly enzyme is a valuable reagent for measurement of ATP concentration. (Dorland, 27th ed) EC 1.13.12.-."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16190] "A country in Western Europe, between France, Belgium, and Germany. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16191] "Trivial name applied, together with dehydratase, to certain hydro-lyases (EC class 4.2.1) catalyzing hydration-dehydration (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16192] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16193] "An x-ray study of lymph nodes and lymphatic vessels made visible by the injection of a special dye."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16194] "A country in Eastern Asia, bordering the South China Sea and China. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16195] "A country in Southern Africa, occupying an island in the Indian Ocean, east of Mozambique. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16196] "(mag-NET-ik REZ-o-nans IM-a-jing) MRI. A procedure in which a magnet linked to a computer is used to create detailed pictures of areas inside the body.  Also called nuclear magnetic resonance imaging."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16197] "Detection and measurement of the resonant spectra of molecular species in a tissue or sample."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16198] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16199] "A group of linked loci, collectively termed H-2 complex in the mouse and HLA complex in humans, that codes for cell-surface histocompatibility antigens and is the principal determinant of tissue type and transplant compatibility."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16200] "A country in Southern Africa, east of Zambia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16201] "A country in Southeastern Asia, occupying a peninsula and the northern one-third of the island of Borneo, bordering Indonesia and the South China Sea, south of Vietnam. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16202] "A country in Southern Asia, occupying a group of atolls in the Indian Ocean, south-southwest of India. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16203] "A country in Western Africa, southwest of Algeria. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16204] "A country in Southern Europe, occupying islands in the Mediterranean Sea, south of Sicily (Italy). (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16205] "(mam-OG-ra-fee) The use of x-rays to create a picture of the breast."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16206] "Encoded by human SOD2 Gene (Fe/Mn SOD Family), 222-aa 25-kDa (precursor) Manganese Superoxide Dismutase is a homotetrameric free radical scavenging indophenoloxidase in the mitochondrial matrix that is required for normal cell function. A first line of defense against toxic superoxide radical byproducts of the energy generating oxidative phosphorylation pathway, MnSOD maintains the integrity of mitochondrial respiratory chain enzymes susceptible to inactivation by superoxide. Reactive oxygen species and oxidative stress are implicated in a range of degenerative processes including ALS, ischemic heart disease, Alzheimer disease, Parkinson disease, and aging. Mitochondria are the chief source of reactive oxygen species in the cell. (NCI)"                                                                                                                                                                                                                          
[16207] "Measurement of the pressure or tension of liquids or gases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16208] "The study of organisms that live in the sea or in other bodies of water."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16209] "A group of atolls and reefs in the North Pacific Ocean, about one-half of the way from Hawaii to Australia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16210] "An island in the Caribbean Sea, north of Trinidad and Tobago. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16211] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16212] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16213] "A country in Northern Africa, bordering the North Atlantic Ocean, between Senegal and Western Sahara. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16214] "A country in Southern Africa, occupying an island in the Indian Ocean, east of Madagascar. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16215] "A country in Southern Africa, occupying an island in the Mozambique Channel, about one-half of the way from northern Madagascar to northern Mozambique. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16216] "(MEE-dee-a-stin-AHS-ko-pee) A procedure in which a tube is inserted into the chest to view the organs in the area between the lungs and nearby lymph nodes. The tube is inserted through an incision above the breastbone. This procedure is usually performed to get a tissue sample from the lymph nodes on the right side of the chest."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16217] "3E; Product Evaluation, Research, and Monitoring; Medical Devices"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16218] "Tests that produce pictures of areas inside the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16219] "A subspecialty of internal medicine concerned with the study of neoplasms. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16220] "The art of preventing or curing disease; the science concerned with disease in all its relations. 2. The study and treatment of general diseases or those affecting the internal parts of the body, especially those not usually requiring surgical intervention. (from STED98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16221] "A special form of cell division in which each daughter cell receives half the amount of DNA as the parent cell. Meiosis occurs during formation of egg and sperm cells in mammals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16222] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16223] "A cell-surface enzyme found on prostate epithelial cells.  It can inhibit cell migration of prostate cancer cells, probably by disrupting focal adhesion kinase phosphorylation. (from J Clin Invest 2000;106:1399-1407 via Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16224] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16225] "(MEN-stroo-al) The monthly cycle of hormonal changes from the beginning of one menstrual period to the beginning of the next."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16226] "for thorough searching see RTs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16227] "Conceptual functions or thinking in all its forms. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16228] "Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16229] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16230] "Encoded by Metalloproteinase Genes, Metalloproteinases (endopeptidases) use a metal ion, normally zinc, in the catalytic process and preferentially cleave the Gln-Gly peptide bond. Metalloproteinases inactivated by metal chelators. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16231] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16232] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16233] "Arrangement of chromosomes in the equatorial plane of the central spindle to form the monaster.  Chromosomes separate into exactly similar halves. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16234] "The manner of performance, or the details, of any surgical operation, experiment, or mechanical act. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16235] "The covalent chemical or biochemical addition of a methyl group(s) to a compound. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16236] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16237] "A country in Central America, bordering the Caribbean Sea and the Gulf of Mexico, between Belize and the US and bordering the North Pacific Ocean, between Guatemala and the US. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16238] "RAEB: The science that deals with the study of microorganisms, including algae, archaea, bacteria, fungi, protozoa, and viruses. (From Dorland, 28th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16239] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16240] "The application of microscope magnification to the study of materials that cannot be properly seen by the unaided eye."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16241] "Visual and photographic microscopy in which electron beams with wavelengths thousands of times shorter than visible light are used in place of light, thereby allowing much greater magnification. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16242] "Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point, giving the surface image a three-dimensional quality. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16243] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16244] "A form of interference microscopy in which variations of the refracting index in the object are converted into variations of intensity in the image. This is achieved by the action of a phase plate. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16245] "Microscopy using polarized light in which phenomena due to the preferential orientation of optical properties with respect to the vibration plane of the polarized light are made visible and correlated parameters are made measurable. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16246] "Microscopy in which the image is formed by ultraviolet radiation and is displayed and recorded by means of photographic film. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16247] "Expression of microsomal epoxide hydrolase (mEH), a carcinogen-activating enzyme, in primary breast tumors may predict poor response to tamoxifen treatment. (from J Clin Oncol 2001;19:3-9 via Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16248] "fall into 2 general categories: large motor proteins (dynein, kinesin), and smaller tubulin-crosslinking proteins (tau proteins)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16249] "RAEB: Electromagnetic radiation between the ultrahigh frequency radio and infrared (in the 10e-3 (micro) to about 0.5 X 10e-1 meter) region of the spectrum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16250] "A minority is a group that is outnumbered by persons who do not belong to it, often people with different nationality, religion, culture or lifestyle from that of the mainstream in the society. (Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16251] "The division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. (GO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16252] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16253] "1. A representation of something, often idealized or modified to make it conceptually easier to understand. 2. Something to be imitated. 3. In dentistry, a cast."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16254] "Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16255] "Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16256] "Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16257] "Mathematical models can aid exploration of the behavior of the system under various conditions from which to determine the dominant factors generating observed patterns and phenomena.  They also aid data collection and interpretation and parameter estimation, and provide tools for identifying possible approaches to control and for assessing the potential impact of different intervention measures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16258] "A country in Eastern Europe, northeast of Romania. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16259] "(1) see MOLECULAR GENETICS; (2) study of biological processes at the molecular level, including membrane biochemistry, cytoskeleton biochemistry, and structural biology in addition to molecular genetics (see NTs and RTs)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16261] "A country in Western Europe, bordering the Mediterranean Sea on the southern coast of France, near the border with Italy. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16262] "A country in Northern Asia, between China and Russia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16263] "A country in the Caribbean, occupying an island in the Caribbean Sea, southeast of Puerto Rico. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16264] "A disease or the incidence of disease within a population. Morbidity also refers to adverse effects caused by a treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16265] "A country in Northern Africa, bordering the North Atlantic Ocean and the Mediterranean Sea, between Algeria and Western Sahara. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16266] "The evolution and development of form, as the development of the shape of a particular organ or part of the body, or the development undergone by individuals who attain the type to which the majority of individuals of the species approximate. (Dorland, 28th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16267] "the ratio of deaths in an area to the population of that area; expressed per 1000 per year."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16268] "The mos proto-oncogene-encoded serine/threonine protein kinase plays a key cell cycle-regulatory role during meiosis. The Mos protein is required for the activation and stabilisation of M phase-promoting factor MPF. As a component of a large multiprotein complex known as the cytostatic factor (CSF), Mos is involved in causing metaphase II arrest of eggs in vertebrates. Upon expression in somatic cells, Mos causes cell cycle perturbations resulting in cytotoxicity and neoplastic transformation. All the known biological activities of Mos are mediated through activation of the mitogen activated protein (MAP) kinase pathway. (from Prog Cell Cycle Res. 1997;3:251-9)"                                                                                                                                                                                                                                                                                                      
[16269] "A country in Southern Africa, bordering the Mozambique Channel, between South Africa and Tanzania. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16270] "An albuminoid substance which is contained in mucus, and gives to the latter secretion its peculiar ropy character. It is found in all the secretions from mucous glands, and also between the fibres of connective tissue, as in tendons. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16272] "Any change in the DNA of a cell.  Mutations may be caused by mistakes during cell division, or they may be caused by exposure to DNA-damaging agents in the environment.  Mutations can be harmful, beneficial, or have no effect.  If they occur in cells that make eggs or sperm, they can be inherited; if mutations occur in other types of cells, they are not inherited.  Certain mutations may lead to cancer or other diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16273] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16274] "Human MYC Gene at 8q24.12-q24.13 encodes c-MYC Protein, a leucine zipper DNA-binding transcription factor involved in cellular responses to growth factors that recognizes CAC(GA)TG sequence. AP2 suppresses MYC expression while beta-catenin bound to TCF4, activates MYC transcription through TCF4 promoter sites. The RAS/RAF/MAPK pathway promotes MYC accumulation by stabilizing MYC protein. Absent mitogenic signals, MYC has a short half-life due to 26S proteasomal degradation. DNA binding requires dimerization with a bHLH protein, such as MAX. MYC activates growth-promoting genes, such as ODC1 and CDC25A, and represses growth arrest gene GAS1 via the MYC BOX2. TERT is activated by MYC-induced expression. MYC also activates E2F genes and S phase requires MYC-induced E2F2 or E2F3. MYC interacts with TGF-beta growth inhibitory signal transducers SMAD2 and SMAD3 to block transcription. (from SWISS-PROT, OMIM, and NCI)"                                       
[16275] "(MY-eh-lo-gram) An x-ray of the spinal cord after an injection of dye into the space between the lining of the spinal cord and brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16276] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16277] "A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. Its physiological acceptor is probably cytochrome P-450. EC 1.6.2.4."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16278] "A country in Southern Africa, bordering the South Atlantic Ocean, between Angola and South Africa. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16279] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16280] "A part of the Centers for Disease Control and Prevention, the NCHS is the primary Federal organization responsible for the collection, analyses, and dissemination of health statistics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16281] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16282] "NIH.  The National Institutes of Health, the focal point of biomedical research in the United States, conducts research in its own laboratories; supports the research of non-Federal scientists in universities, medical schools, hospitals, and research institutions throughout the country and abroad; helps in the training of research investigators; and fosters communication of medical information.  Access the NIH Web site at http://www.nih.gov."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16283] "A country in Oceania, occupying an island in the South Pacific Ocean, south of the Marshall Islands. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16284] "(ne-KRO-sis) Refers to the death of living tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16285] "An integral component of HIV-1 particles. Nef facilitates a step in the viral life cycle occurring between penetration and reverse transcription (Aiken. Virology 1998; 248:139-147)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16286] "The extent of a cancer within the body, especially whether the disease has spread from the original site to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16287] "Growth of new blood vessels feeding a tissue, as with a tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16288] "A country in Southern Asia, between China and India. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16289] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16290] "A country in Western Europe, bordering the North Sea, between Belgium and Germany. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16291] "A country in the Caribbean, comprising two island groups in the Caribbean Sea - one includes Curacao and Bonaire north of Venezuela; the other is east of the Virgin Islands. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16292] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16293] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16294] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16295] "the branch of medical science that deals with the study of structure, function, and diseases of the nervous system; for thorough searching also see NEUROSCIENCE, MENTAL DISORDER, NERVOUS SYSTEM DISORDER, NERVOUS SYSTEM DISORDER DIAGNOSIS, MENTAL DISORDER DIAGNOSIS, NERVOUS SYSTEM DISORDER CHEMOTHERAPY, COMMUNICATION DISORDER, NEUROMUSCULAR DISORDER."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16296] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16297] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16298] "study of the relationships between behavior, experience, and neurophysiological processes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16299] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16300] "A country in the Pacific, comprised of islands in the South Pacific Ocean, east of Australia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16301] "A country in the Pacific, comprised of islands in the South Pacific Ocean, southeast of Australia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16302] "A country in Central America, bordering both the Caribbean Sea and the North Pacific Ocean, between Costa Rica and Honduras. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16303] "A country in Western Africa, southeast of Algeria. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16304] "A country in Western Africa, bordering the Gulf of Guinea, between Benin and Cameroon. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16305] "A country in the Pacific, occupying an island in the South Pacific Ocean, east of Tonga. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16306] "A country in the Pacific, occupying an island in the South Pacific Ocean, east of Australia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16307] "A country in Northern Europe, bordering the North Sea and the North Atlantic Ocean, west of Sweden. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16308] "Spectroscopic method of measuring the magnetic moment of atomic nuclei in a covalent bond. Clinical application is in biochemical, metabolic, and physiologic studies of living tissue. It includes proton and electron spin-echo and spin-relaxation times. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16309] "Nuclear Medicine is the branch of medicine that uses radioactive materials either to image a patient's body or to destroy diseased cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16310] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16311] "The zipping reaction between complementary DNA or RNA single strands to form a duplex (double stranded) molecule is the basis of many techniques for assaying nucleic acid sequence complementarity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16312] "nucleotidyltransferases. Enzymes (EC class 2.7.7) transferring nucleotide residues (nucleotidyls) from nucleoside di- or triphosphates into dimer or polymer forms. Some nucleotidyltransferases bear specific names (e.g., adenylyltransferases), or trivial names indicating the linkage hydrolyzed in the synthesis (pyrophosphorylases, phosphorylases), or names of the material synthesized (RNA or DNA polymerase)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16313] "Nursing encompasses autonomous and collaborative care of individuals of all ages, families, groups and communities, sick or well and in all settings. Nursing includes the promotion of health, prevention of illness, and the care of ill, disabled and dying people. Advocacy, promotion of a safe environment, research, participation in shaping health policy and in patient and health systems management, and education are also key nursing roles. (ICN 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16314] "RAEB: The science of food, the nutrients and other substances contained therein, their action, interaction, and balance in relation to health and disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16315] "Obstetrics is the surgical specialty dealing with the care of a woman and her offspring during pregnancy, childbirth and the puerperium (the period shortly after birth). (Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16316] "The exposure to potentially harmful agents that occurs as a result of one's occupation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16317] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16318] "Medical specialty concerned with the promotion and maintenance of the physical and mental health of employees in occupational settings. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16319] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16320] "A country in the Middle East, bordering the Arabian Sea, Gulf of Oman, and Persian Gulf, between Yemen and UAE. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16321] "A general term referring to the gene product of an oncogene. (http://www.copewithcytokines.de/cope.cgi?7308)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16322] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16323] "A gene that normally directs cell growth. If altered, an oncogene can promote or allow the uncontrolled growth of cancer. Alterations can be inherited or caused by an environmental exposure to carcinogens."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16324] "Nursing care provided cancer patients. It includes aspects of family functioning through education of both patient and family. The specialty of oncologic nursing focuses on cancer as a major health care problem. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16325] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16326] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16327] "Optics is the branch of physics that describes the behavior and properties of light and the interaction of light with matter. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16328] "The maintenance or growth of tissues, organ primordia, or the parts or whole of an organ in vitro in such a way as to allow differentiation or preservation of the architecture or function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16329] "A surgical specialty which utilizes medical, surgical, and physical methods to treat and correct deformities, diseases, and injuries to the skeletal system, its articulations, and associated structures. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16330] "Ear, nose, and throat medicine"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16331] "Process in which molecules are split to give products that have unpaired electrons."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16332] "A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471). (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16333] "The class of all enzymes catalyzing oxidoreduction reactions (EC class 1). The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor: acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16334] "Likely expressed primarily in vascular endothelia by single copy human SERPINE1 Gene (Serpin Family), 402-aa 45-kDa (nonglycosylated, predicted) secreted plasma Plasminogen Activator Inhibitor 1 is an acid-stable glycoprotein in plasma, platelets, and endothelia with structural similarity to angiotensinogen, alpha-1-antitrypsin, and antithrombin III. PAI-1 acts as bait for tissue plasminogen activator, urokinase, and protein C; rapid interaction with TPA may regulate fibrinolysis. SERPINE1 defects cause of PAI-1 deficiency. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16335] "Expressed in keratinocytes, monocytes, macrophages, placenta, and trophoblast by human SERPINB2 Gene (Serpin Family), 415-aa 47-kDa (predicted, unglycosylated) cytoplasmic Plasminogen Activator Inhibitor 2 is a specific inhibitor of urokinase-type plasminogen activator thought to regulate plasminogen activation in the extravascular compartment and to have a possible role in placental maintenance or embryo development. The primary intracellular distribution of SERPINB2 may also indicate a regulatory role in a protease-dependent cellular process such as apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                     
[16336] "A country in Southern Asia, bordering the Arabian Sea, between India on the east and Iran and Afghanistan on the west and China in the north. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16337] "Examination by pressing on the surface of the body to feel the organs or tissues underneath."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16338] "A country in Central America, bordering both the Caribbean Sea and the North Pacific Ocean, between Colombia and Costa Rica. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16339] "A country in Southeastern Asia, comprising a group of islands and including the eastern half of the island of New Guinea, between the Coral Sea and the South Pacific Ocean, east of Indonesia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16340] "A country in Central South America, northeast of Argentina. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16341] "A branch of biology which deals with parasitic organisms with a strong emphasis on their role in disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16342] "condition of a female with respect to her having borne viable offspring."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16343] "A biologic function or a process having an abnormal or deleterious effect at the subcellular, cellular, multicellular, or organismal level. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16344] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16345] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16346] "The teaching or training of patients concerning their own health needs. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16347] "A person who requires medical care."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16348] "In information retrieval, machine-sensing or identification of visible patterns (shapes, forms, and configurations). (Harrod's Librarians' Glossary, 7th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16349] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16350] "An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16351] "An enzyme that brings about the hydrolysis of a beta-lactam (as penicillin to penicilloic acid); found in most staphylococcus strains that are naturally resistant to penicillin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16352] "Enzymes acting on peptide bonds. EC 3.4.-"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16353] "The sequential formation of peptide bonds between amino acids"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16354] "the process of producing an internal, conscious image through stimulating a sensory system; it involves the recognition that stimulation has occurred, and the ability to discriminate various aspects of the stimulus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16355] "(pair-ih-STAL-sis) The rippling motion of muscles in the intestine or other tubular organs characterized by the alternate contraction and relaxation of the muscles that propel the contents onward."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16356] "(lap-a-RAHS-ko-pee) The insertion of a thin, lighted tube (called a laparoscope) through the abdominal wall to inspect the inside of the abdomen and remove tissue samples."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16357] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16358] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16359] "A country in Western South America, bordering the South Pacific Ocean, between Chile and Ecuador. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16360] "Pharmacogenetics is broadly defined as the effect of inheritance on individual variations in response to drugs and xenobiotics. These variations may involve individual differences in therapeutic efficacy or adverse drug reactions. (from Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16361] "RAEB: The study of the origin, nature, properties, and actions of drugs and their effects on living organisms. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16362] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16363] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16364] "The phenotype of an individual organism is either its total physical appearance and constitution, or a specific manifestation of a trait, such as size or eye color, that varies between individuals. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16365] "A country in Southeastern Asia, comprised of an archipelago between the Philippine Sea and the South China Sea, east of Vietnam. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16366] "Various types of calcium-dependent or -independent Phospholipases A2 hydrolyze phospholipids. Group I, II, and III phospholipases are secreted, while group IV phospholipases are cytosolic. The best characterized phospholipases are group II. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16367] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16368] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16369] "Proteins that contain phosphate groups esterified to serine, threonine or tyrosine. The phosphate group usually regulates protein function. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16370] "The creation of a phosphate derivative of an organic molecule. This is usually achieved by transferring a phosphate group from ATP via the action of a kinase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16371] "A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16372] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16373] "The formation of carbohydrates, with release of molecular oxygen, from carbon dioxide and water in the chlorophyll tissue of plants and blue-green algae under the influence of light.  In bacteria, photosynthesis uses hydrogen sulfide, molecular hydrogen, and other reduced compounds in place of water, so that molecular oxygen is not released. (Dorland, 27th ed.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16374] "tree section heading for chemistry, physics, and related terms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16375] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16376] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16377] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16378] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16379] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16380] "A country in the Pacific, coprised of islands in the South Pacific Ocean, about midway between Peru and New Zealand. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16381] "Plasminogen is a precursor of the potent serine protease plasmin and occurs at high concentrations in body fluids. Activation of plasminogen to the enzymatically active form plasmin is a proteolytic event and tightly controlled. A key feature in the formation and stability of plasmin activity is the attachment of plasminogen (and also of the formed plasmin) onto lysine-containing residues on target protein, such as fibrin. Plasmin cleaves fibrin clots and e.g. noncollagenous proteins of basement membranes and extracellular matrices, such as laminin and fibronectin. Plasmin also activates latent procollagenases and is thought to be crucial for the penetration of metastatic tumnor cells into basement membranes."                                                                                                                                                                                                                                                     
[16382] "A secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16383] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16384] "synthesized and secreted locally from vascular endothelial cells; primary physiologic inhibitor of tissue plasminogen activator; also inhibits urokinase; implicated in thrombotic and hemorrhagic disorders."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16385] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16386] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16387] "Having different forms at different stages of the life cycle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16388] "(PLOY-dee) The number of sets of chromosomes in a cell or an organism.  For example, haploid means one set and diploid means two sets."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16389] "A country in Central Europe, east of Germany. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16390] "PCR. A laboratory method used to make many copies of a specific DNA sequence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16391] "A common variation or mutation in DNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16392] "Groups of individuals united by a common factor e.g. geographic location, ethnicity, disease, age, gender, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16393] "A country in Southwestern Europe, bordering the North Atlantic Ocean, west of Spain. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16394] "A noninvasive imaging method that provides information about cellular activity (metabolic information).  It is used along with magnetic resonance imaging (MRI) which provides information about the shape and size of the tumor (spacial information)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16395] "Cell membrane glycoproteins selective for potassium ions. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16396] "A situation in which the level of living of an individual, family, or group is below the standard of the community. It is often related to a specific income level. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16397] "the ratio (for a given time period) of the number of occurrences of a disease or event to the number of units at risk in the population."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16398] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16399] "(prok-TOS -ko-pee) An examination of the rectum using a thin, lighted tube called a proctoscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16400] "(prog-NO-sis) The likely outcome or course of a disease; the chance of recovery or recurrence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16401] "Formation of paired chromosomes; disappearance of nuclear membrane; appearance of the achromatic spindle; formation of polar bodies.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16402] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16403] "A dental specialty concerned with the restoration and maintenance of oral function by the replacement of missing teeth and structures by artificial devices or prostheses. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16404] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16405] "group of enzymes under review by NC-IUBMB include EC 2.7.1.38, EC 2.7.1.70, EC 2.7.1.99, EC 2.7.1.109, EC 2.7.1.110, EC 2.7.1.111, EC 2.7.1.115, EC 2.7. 1.116, EC 2.7.1.124, EC 2.7.1.135, and EC 2.7.1.141."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16406] "Any of various enzymically catalyzed post-translational modifications of peptides or proteins in the cell of origin. These modifications include carboxylation, hydroxylation, acetylation, phosphorylation, methylation, glycosylation, oxidation-reduction, degradation and lysis, peptide bond formation, and changes in molecular weight and electrophoretic motility. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16407] "Enzymes that catalyze the phosphorylation of tyrosine residues in proteins with ATP or other nucleotides as phosphate donors. EC 2.7.1.112.  This class of kinases was originally identified in the src transforming gene of Rous sarcoma virus. (MSH98 and Cooper & Hunt 1981)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16408] "Any of a group of complex organic macromolecules that contain carbon, hydrogen, oxygen, nitrogen, and usually sulfur and are composed of one or more chains of amino acids. Proteins are fundamental components of all living cells and include many substances, such as enzymes, hormones, and antibodies, that are necessary for the proper functioning of an organism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16409] "A molecule that contains both protein and glycosaminoglycans, which are a type of polysaccharide.  Proteoglycans are found in cartilage and other connective tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16410] "Oncogenes are altered forms of normal cellular genes called proto-oncogene. Many proto-oncogenes are homologous to viral oncogenes and involved in the control of cell proliferation or differentiation. Mutations, amplifications or rearrangements of proto-oncogenes lead to upregulated or deregulated cell growth and allow them to function as oncogenes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16411] "A small, positively charged particle of matter found in the atoms of all elements.  Streams of protons generated by special equipment can be used for radiation treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16412] "A specialty concerned with the application of psychiatric principles in caring for the mentally ill. It also includes the nursing care provided the mentally ill patient. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16413] "for thorough searching see RTs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16414] "study of mental and behavioral phenomena in individuals and groups; human and nonhuman species are included."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16415] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16416] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16417] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16418] "A subdiscipline of psychiatry that is concerned with the study of conditioning, learning, perception, motivation, emotion, language, and thinking; also used in relation to subject-matter areas in which experimental methods are emphasized."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16419] "The branch of applied psychology concerned with the application of psychologic principles and methods to industrial problems including selection and training of workers, working conditions, etc. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16420] "The branch of psychology concerned with the effects of group membership upon the behavior, attitudes, and beliefs of an individual. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16421] "assessment of psychological parameters by statistical or mathematical procedures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16422] "the study of disorders of the psyche."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16423] "1. The use of drugs to treat mental and psychological disorders. 2. The science of drug-behavior relationships."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16424] "branch of psychology which experimentally investigates the physiological basis of behavior, including anatomical structures, psychological processes, and mental functions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16425] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16426] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16427] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16428] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16429] "Relations of an individual, association, organization, hospital, or corporation with the publics which it must take into consideration in carrying out its functions. Publics may include consumers, patients, pressure groups, departments, etc. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16430] "An island between the Caribbean Sea and the North Atlantic Ocean, east of the Dominican Republic. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16431] "Use of a pulse of X-rays or fast electrons to generate free radicals for spectroscopic examination. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16432] "A country in the Middle East, occupying a peninsula bordering the Persian Gulf and Saudi Arabia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16433] "The levels of excellence which characterize the health service or health care provided based on accepted standards of quality."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16434] "The overall enjoyment of life. Many clinical trials measure aspects of an individual's sense of well-being and ability to perform various activities to assess the effects of cancer and its treatment on the quality of life."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16435] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16436] "Race is a taxonomic principle used to group living things based on common heredity, physical attributes and behavior, where all members belong to the same species yet appear to warrant further classification. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16437] "All radiation, ionizing and non-ionizing. Not for diagnosis or therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16438] "The ability of some cells or tissues to withstand ionizing radiation without serious injury. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16439] "RAEB: This category is for low level radiation carcinogenesis, mutagenesis, and biology, not diagnosis or therapy, unless the focus is on harmful side effects of these procedures (e.g. second tumors presumably resulting from radiation therapy of a previous tumor) or on basic interactions of radiation with biological molecules. (For non-low level, use Ionizing Radiation.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16440] "Electromagnetic radiation which does not produce ions in matter through which it passes. Its wavelengths are generally greater than those of far ultraviolet radiation and range through the longest radio waves. Nonionizing counterpart of SIC 26 (Non-ionizing radiation). Includes ultraviolet, visible light, infrared, radar, microwaves, radio waves, electromagnetic fields, radar devices, MRI (deleterious effects only); see also SIC 161 (Electromagnetic fields). Use for electromagnetic spectrum only; keep ultrasound in separate category."                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16441] "The quality of emitting or the emission of corpuscular or electromagnetic radiations consequent to nuclear disintegration, a natural property of all chemical elements of atomic number above 83 and possible of induction in all other known elements."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16442] "The study of the mechanisms and biological effects of ionizing radiation, including repair processes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16443] "Radiochemistry the science concerned with the effects of ionizing or nuclear radiation on chemical reactions or materials. (from On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16444] "quantitative chemical test based on displacement of radioligand from antigen-antibody complex; usually the radioligand and unknown are antigens; antibody specificity permits use of crude samples and antisera."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16445] "Health concerns associated with the effects of radiation on the environment and on public and personal health. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16446] "RAEB: The science of high energy radiation and of the sources and the chemical, physical, and biologic effects of such radiation; the term usually refers to the diagnosis and treatment of disease. 2. The scientific discipline of medical imaging using ionizing radiation, radionuclides, nuclear magnetic resonance, and ultrasound. (STED98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16447] "This gene encodes Harvey ras that binds GTP and transmits signals from growth factor receptors.(from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16448] "Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein. Critically involved in cell activation and replication in many cell types, and disruption of its regulation can lead to uncontrolled growth."                                                                                                                                                                                                                                                                                                
[16449] "Expressed by Beta Adrenergic Receptor Genes in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Beta Adrenergic Receptors are one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Beta-adrenergic receptors respond to blocking agents such as propranolol and to activating agents such as isoproterenol. Beta-1 type receptors mediate lipolysis and increase cardiac rate and force of contraction; beta-2 type receptor activation promotes bronchial and vascular smooth muscle relaxation. When coupled to adenylate cyclase through Gs protein, Beta Adrenergic Receptor stimulation results in increased intracellular cyclic AMP. (NCI)"                                                                                                           
[16450] "Encoded by human AR Gene (NR3 Family), the Androgen Receptor transcription factor regulates gene expression, cell proliferation, and differentiation. AR has 3 domains: N-terminal modulating (exon 1), DNA-binding (two C4 Zinc fingers, exons 2-3), and C-terminal hormone-binding (5 remaining exons). Polymorphic N-terminal poly-Gln tracts bind RAN, enhancing transactivation; decreased with increased poly-Gln length. An 87-kD (AR-A) isoform lacks a normal N-terminus, seen in the 110 kD (AR-B) form; A and B may differ in function. Ligand bound receptor translocates to the nucleus, homodimerizes, binds DNA, and stimulates transcription. Polyglutamine expansion causes Kennedy's disease. Other mutations are associated with androgen insensibility syndrome. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                   
[16451] "A product of the MAS1 Gene, an oncogene isolated from DNA of a human epidermoid carcinoma cell line.  Based on its deduced amino acid sequence, the MAS1 gene product contains 7 potential transmembrane domains. The MAS1 protein is, therefore, probably an integral membrane protein.  The structure of the MAS oncogene indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices.  It is predicted that it would encode a peptide receptor with mitogenic activity which would act through the inositol lipid signaling pathways. Expression in Xenopus oocytes and a transfected mammalian cell line demonstrated that the MAS gene product is a functional angiotensin receptor. (from OMIM)"                                                                     
[16452] "Heterodimeric antigen receptors present on the surface of T-cells.  Two T-cell antigen receptors have been identified, consisting of heterodimeric 40-55 kD Ig-like alpha/beta or gamma/delta integral membrane glycoproteins.  Genes for TCR alpha, beta, gamma, and delta subunits are assembled during T-cell development by somatic rearrangement of germline gene segments, resembling B-cell Ig genes in their mechanisms of diversity generation and activation of expression.  Alpha/beta heterodimers are found on helper and cytotoxic T-cells and are specific for antigenic peptides presented by MHC gene products.  T-cells expressing gamma/delta heterodimers directly recognize proteins and non-proteinacious phospho-ligands.  T-cell receptors are non-covalently associated with CD3, forming the TCR-CD3 complex.  TCRs activate MAPKs and JNK1 through the CD3 antigens, the adaptor protein LAT, and tyrosine kinases LCK and ZAP70.  (from OMIM and NCI)"                  
[16453] "family of G protein-coupled receptors of two general classes: D1 (- A, -B) stimulation increases intracellular cAMP, whereas D2, D3, or D4 stimulation decreases cAMP, increases K+ flux, or decreases Ca++ flux."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16454] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16455] "Epidermal growth factor receptor. The protein found on the surface of some cells and to which epidermal growth factor binds, causing the cells to divide. It is found at abnormally high levels on the surface of many types of cancer cells, so these cells may divide excessively in the presence of epidermal growth factor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16456] "ER. Protein found on some cancer cells to which estrogen will attach."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16457] "Receptors found on the cell surface of some B-lymphocytes, T-lymphocytes, and macrophages, which recognize the Fc (constant region fragment) portion of immunoglobulin molecules."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16458] "Widely expressed by human NR3C1 Gene (NR3 Family) as 6 isoforms, phosphorylated cytoplasmic (inactive)/hyperphosphorylated nuclear (active) Glucocorticoid Receptor contains a (N) modulating domain, a DNA-binding domain, and a (C) steroid-binding domain. Alpha-A (777-aa, 86-kDa precursor) predominates. Complexed with HSP90, HSP70, and FKBP5 or PPP5C, activate GR is transported (by dynein/FKBP4) to the nucleus and binds to target GREs as a homodimeric or heterodimeric (NR3C2/RXR) transcription factor and modulates other transcription factors to regulate blood glucose concentration, protein/fat metabolism, inflammatory responses, cell proliferation, and differentiation. GR appears to interact with NRIP1, POU2F1, POU2F2, STAT5A, STAT5B, SMARCA4, CREBBP/EP300, TADA2L, p160, NCOA2, and NCOA6. Sumoylation and BAG1 interaction inhibits transactivation. GR defects cause glucocorticoid resistance. (NCI)"                                                         
[16459] "a tyrosine kinase type, transmembrane receptor, which places it in the growth factor receptor family, even though insulin is usually considered a hormone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16460] "The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16461] "The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. (LocusLink)"                                                                                                                                                                                                                                                                                                   
[16462] "Progesterone receptor negative.  Breast cancer cells that do not have a protein (receptor molecule) to which progesterone will attach. Breast cancer cells that are PR- do not need the hormone progesterone to grow and usually do not respond to hormonal therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16463] "The Prolactin Receptor binds prolactin, initiating the cellular response to the hormone.  The receptor is found in breast, placenta, liver, testes, kidneys, ovaries, and other organs.  The prolactin receptor is homologous to members of the cytokine receptor superfamily, such as GHR, IL2R, IL3R, IL4R, IL6R, IL7R, EPOR, and GMCSFR.  PRLR isoforms differ in the length of their cytoplasmic domains.  The short form acts as a dominant-negative inhibitor, forming inactive heterodimers that inhibit Janus kinase 2 activation.  (from OMIM 176761 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                             
[16464] "Cell surface proteins that bind purines with high affinity and trigger intracellular changes which influence the behavior of cells. The best characterized classes of purinergic receptors in mammals are the P1 receptors, which prefer adenosine, and the P2 receptors, which prefer ATP or ADP."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16465] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16466] "Homodimeric human Transferrin Receptors (M28B Peptidase Family) are type II membrane proteins involved in the cellular import of transferrin-bound iron and appear necessary for iron metabolism, cell function, and erythrocyte differentiation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16467] "Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16468] "peptides or proteins produced by genes which have been artificially inserted into living cells or cell-free expression systems; index with or without RECOMBINANT DNA and the following RTs as needed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16469] "A natural process of exchange of DNA between chromosomes during mitosis; not recombinant DNA, which applies to artificial DNA constructs. The production of new arrangements of genes by various mechanisms such as assortment and segregation, crossing over, gene conversion, transformation, conjugation, transduction, F-duction, or mixed infection of viruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16470] "Reproduction or reconstitution of a lost or injured part. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16471] "Human REL Gene (REL/Dorsal Family) at 2p13-p12 encodes REL Protein, which may play a role in differentiation and lymphopoiesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16472] "A personal or institutionalized system grounded in belief and reverence for a supernatural power or powers regarded as creator and governor of the universe. (from dictionary.com)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16473] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16474] "Reproduction is the creation of one thing as a copy of, product of, or replacement for a similar thing.  It is commonly used in the context of biological reproduction and sex. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16475] "In a Request for Proposals (RFPs) the Government states work to be undertaken or a problem to be solved.  Respondents compete for a common requirement open to all eligible offerors/bidders. Proposals are evaluated using technical and business evaluation criteria and generally involve negotiations. Bids are awarded to the bidder who is responsible and offers the lowest overall price. (from Acquisition Program)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16476] "A researcher in a clinical trial or clinical study."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16477] "This includes all types of grants, cooperative agreements, and research contracts that support research directly and for which individuals and/or projects have been peer-reviewed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16478] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16479] "Functions and activities of the respiratory tract as a whole or of any of its parts. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16480] "Restriction fragment length polymorphism (RFLP). Variation occurring within a species in the length of DNA fragments generated by a specific endonuclease. Such variations are generated by mutations that create or abolish recognition sites for these enzymes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16481] "Use of restriction endonucleases to generate a physical map of genomes, genes, or other segments of DNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16482] "An Southern Africa, occupying an island in the Indian Ocean, east of Madagascar. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16483] "RNA-dependent DNA polymerase.  Enzyme involved in the replication of retroviruses, synthesizing a DNA viral intermediate that is then integrated into the host genome as a provirus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16484] "The action of copying RNA into DNA by reverse transcriptase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16485] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16486] "Enzymes that catalyze the hydrolysis of RNA"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16487] "Ribonucleotide Reductase is a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. It consists of two subunits, M1 Chain and M2 Chain. Complex allosteric control, mediated by deoxynucleoside triphosphates, and by ATP bound to the M1 subunit prevents DNA replication and cell proliferation. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. (NCI)"                                                                                                                                                                                                                                                                                                      
[16488] "The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16489] "Anything that increases a person's chance of developing a disease. Some examples of risk factors for cancer include a family history of cancer, use of tobacco products, certain foods, exposure to radiation or cancer-causing agents, and certain genetic alterations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16490] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16491] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16492] "Removal of introns from mRNA precursors and the reattachment or annealing of exons."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16493] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16494] "A country in Southeastern Europe, bordering the Black Sea, between Bulgaria and Ukraine. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16495] "The status of health in rural populations. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16496] "RAEB: Populations living away from the congestion of city or suburb."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16497] "A country in Northern Asia (that part west of the Urals is sometimes included with Europe), bordering the Arctic Ocean, between Europe and the North Pacific Ocean. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16498] "A country in Central Africa, east of Democratic Republic of the Congo. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16499] "A country in the Caribbean, occupying an island between the Caribbean Sea and North Atlantic Ocean, north of Trinidad and Tobago. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16500] "A country in the Caribbean, comprised of islands in the Caribbean Sea, north of Trinidad and Tobago. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16501] "A country in Southern Europe, an enclave in central Italy. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16502] "A country in Western Africa, comprised of islands in the Gulf of Guinea, straddling the Equator, west of Gabon. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16503] "A country in the Middle East, bordering the Persian Gulf and the Red Sea, north of Yemen. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16504] "Educational institutions. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16505] "Production by a cell or aggregation of cells (a gland) of a physiologically active substance and its movement out of the cell or organ in which it is formed.  Discharge across the cell membrane, into the intracellular space or ducts, of endogenous substances resulting from the activity of intact cells of glands, tissues, or organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16506] "A group of people with similar disease who meet to discuss how better to cope with their disease and treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16507] "A country in Western Africa, bordering the North Atlantic Ocean, between Guinea-Bissau and Mauritania. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16508] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16509] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16510] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16511] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16512] "Dissolved proteins of blood plasma.  These mainly consist of albumins and globulins and include antibodies and blood-clotting proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16513] "Sexual behavior is a form of physical intimacy that can be directed to reproduction (one possible goal of sexual intercourse) and/or to enjoying the body of someone else; activities associated with sexual intercourse. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16514] "Expressed as 2 alternative isoforms in Sertoli cells and liver by human SHBG Gene, 402-aa 44-kDa (precursor) homodimeric Sex Hormone-Binding Globulin is a secreted beta-globulin plasma glycoprotein containing 2 laminin G-like domains that specifically bind 5-alpha-dihydrotestosterone, testosterone, or 17-beta-estradiol. An androgen transport protein, SHBG regulates the plasma metabolic clearance rate of steroid hormones by controlling plasma concentration and may be involved in receptor-mediated processes as well. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16515] "A country in Eastern Africa, comprised of a group of islands in the Indian Ocean, northeast of Madagascar. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16516] "A country in Western Africa, bordering the North Atlantic Ocean, between Guinea and Liberia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16517] "(PROK-toe-sig-moid-OSS-ko-pee) An examination of the rectum and the lower part of the colon using a thin, lighted tube called a sigmoidoscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16518] "any process which helps to produce biological responses to events in the environment or internal milieu; e.g., transduction of light into nerve impulses by the retina, or transduction of hormone binding into cellular events by hormone receptors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16519] "A country in Southeastern Asia, comprised of islands between Malaysia and Indonesia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16521] "An exchange of homologous segments of genetic material between the sister chromatids of a chromosome, either between the sister chromatids of a meiotic tetrad or between the sister chromatids of a duplicated somatic chromosome. Its frequency is increased as a result of inordinate chromosomal fragility due to genetic or environmental factors such as ultraviolet or ionizing radiation and other mutagenic agents, and is particularly high in Bloom Syndrome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16522] "A test for an immune response to a compound by placing it on or under the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16523] "A country in Central Europe, bordering the Adriatic Sea, between Austria and Croatia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16524] "Smell; the faculty of smell, the sensation that results when olfactory receptors in the nose are stimulated by particular chemicals in gaseous form."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16525] "Exposure to tobacco smoke products among individuals who do not smoke. This can result from sharing space with a smoker or from placental transfer from mother to fetus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16526] "Disciplines concerned with the interrelationships of individuals in a social environment including social organizations and institutions. Includes Sociology and Anthropology. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16527] "The use of community resources, individual case work, or group work to promote the adaptive capacities of individuals in relation to their social and economic environments. It includes social service agencies. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16529] "The study of the social determinants and social effects of health and disease, and of the social structure of medical institutions or professions. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16531] "data and instructions stored in the computer in a format to be used by the computer for its processing functions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16533] "A group of islands in the South Pacific Ocean, east of Papua New Guinea. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16534] "A country in Eastern Africa, bordering the Gulf of Aden and the Indian Ocean, east of Ethiopia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16535] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16536] "A country in Southern Africa, at the southern tip of the continent of Africa. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16537] "A country in Southwestern Europe, bordering the Bay of Biscay, Mediterranean Sea, North Atlantic Ocean, and Pyrenees Mountains, southwest of France. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16538] "Medical Specialty; the branches of medical science that deal with nonsurgical techniques."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16539] "RAEB: Use only for treatment or diagnosis, not for research tool."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16540] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16541] "Analysis of the mass of an object through means of determining the wave length(s) at which electromagnetic energy is absorbed by that object. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16542] "Emission of electromagnetic energy with a shorter frequency (longer wavelength) than that of the incident monochromatic light.  Arises from the low probability absorption of quanta with a higher energy than that required for a transition: the difference in energy is emitted as a lower frequency (energy) photon.  Allows analysis of vibrational and rotational energy levels using visible incident light."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16543] "(SPEK-yoo-lum) An instrument used to widen an opening of the body to make it easier to look inside."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16544] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16545] "(eh-SOF-a-JEE-al) Speech produced by trapping air in the esophagus and forcing it out again.  It is used after removal of a person's larynx (voice box)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16546] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16547] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16548] "A country in Southern Asia, occupying an island in the Indian Ocean, south of India. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16549] "Islands in the South Atlantic Ocean, about midway between South America and Africa. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16550] "A country in Northern North America, comprised of islands in the North Atlantic Ocean, south of Newfoundland (Canada). (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16551] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16552] "A branch of applied mathematics concerned with the collection and interpretation of quantitative data and the use of probability theory to estimate population parameters."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16553] "A device placed in a body structure (such as a blood vessel or the gastrointestinal tract) to provide support and keep the structure open."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16554] "Components of a cell produced by various separation techniques which, though they disrupt the delicate anatomy of a cell, preserve the structure and physiology of its functioning constituents for biochemical and ultrastructural analysis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16555] "A country in Northern Africa, bordering the Red Sea, between Egypt and Eritrea. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16556] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16557] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16558] "The branch of medical science that treats disease or injury by operative procedures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16559] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16560] "A country in Northern South America, bordering the North Atlantic Ocean, between French Guiana and Guyana. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16561] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16562] "Continuance of life or existence especially under adverse conditions; includes methods and philosophy of survival."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16563] "Islands between the Arctic Ocean, Barents Sea, Greenland Sea, and Norwegian Sea, northeast of Iceland and north of Norway. The US State Department considers these as separate entities, each with its own code (SV and JN, respectively). (from CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16564] "A country in Southern Africa, between Mozambique and South Africa. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16565] "A country in Northern Europe, bordering the Baltic Sea, Gulf of Bothnia, Kattegat, and Skagerrak, between Finland and Norway. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16566] "A country in Central Europe, east of France, north of Italy. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16568] "A country in Central Asia, west of China. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16569] "A group of islands bordering the East China Sea, Philippine Sea, South China Sea, and Taiwan Strait, north of the Philippines, off the southeastern coast of China. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16570] "A country in Eastern Africa, bordering the Indian Ocean, between Kenya and Mozambique. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16571] "A nucleolar, HIV-encoded transcriptional regulator that binds to the RNA Trans-Activating Responsive (TAR) sequence. TAT activates transcription initiation and/or elongation from the LTR promoter. TAT may bind Cyclin T1. (from SWISS-PROT P24738 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16572] "The application of scientific knowledge to practical purposes in any field. It includes methods, techniques, and instrumentation. (MSH2000)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16573] "Communications over distance by telephone, TV, radio, computer modem , or similar means."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16574] "The daughter chromosomes resolve themselves into a reticulum and the daughter nuclei are formed; the cytoplasm then divides, forming two complete daughter cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16575] "catalyzes the reduction of testosterone to 5 alphadihydrotestosterone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16576] "Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids.  It is a drug target.  Variation in gene expression or sequence may alter the efficacy of chemotherapy. (from LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16577] "A country in Southeastern Asia, bordering the Andaman Sea and the Gulf of Thailand, southeast of Burma. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16578] "branch of chemistry concerned with heat and other energetic characteristics of chemical reactions and states."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16579] "A diagnostic technique using a thermograph to record the heat produced by different parts of the bod.  It can be used to study blood flow and to detect tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16580] "A surgical specialty concerned with diagnosis and treatment of disorders of the heart, lungs, and esophagus. Two major types of thoracic surgery are classified as pulmonary and cardiovascular. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16581] "The use of a thin, lighted tube (called an endoscope) to examine the inside of the chest."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16582] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16583] "Human Thymidine Kinases (Thymidine Kinase Family) catalyze thymidine phosphorylation via ATP to deoxythymidine monophosphate. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16584] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16585] "A country in Southeastern Asia, northwest of Australia in the Lesser Sunda Islands at the eastern end of the Indonesian archipelago. East Timor includes the eastern half of the island of Timor, the Oecussi (Ambeno) region on the northwest portion of the island of Timor, and the islands of Pulau Atauro and Pulau Jaco. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16586] "Maintaining or growing of tissue, organ primordia, or the whole or part of an organ in vitro so as to preserve its architecture and/or function (Dorland, 28th ed). Tissue culture includes both ORGAN CULTURE and CELL CULTURE. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16587] "A country in Western Africa, bordering the Bight of Benin, between Benin and Ghana. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16588] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16589] "A series of detailed pictures of areas inside the body; the pictures are created by a computer linked to an x-ray machine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16590] "An archipelago in the South Pacific Ocean, about two-thirds of the way from Hawaii to New Zealand. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16591] "RAEB: The science concerned with the detection, chemical composition, and pharmacologic action of toxic substances or poisons and the treatment and prevention of toxic manifestations. (MSH99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16592] "diverse group of viral, prokaryotic, and eukaryotic proteins which interact with specific sites on DNA or its associated proteins to initiate or inhibit transcription; not all are DNA binding proteins per se, although that is a BT."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16593] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16594] "technique of transferring DNA into somatic cells or germ lines of experimental animals so that the cells or progeny may express the integrated donor gene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16595] "Transferases are enzymes transferring a group, for example, the methyl group or a glycosyl group, from one compound (generally regarded as donor) to another compound (generally regarded as acceptor). The classification is based on the scheme \"donor: acceptor group transferase\". (EC 2 class)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16596] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16597] "The change that a normal cell undergoes as it becomes malignant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16598] "The process that occurs at the ribosome whereby the information in mRNA is used to specify the sequence of amino acids in a polypeptide chain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16599] "The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal (disease transmission, horizontal) or vertical (disease transmission, vertical). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16600] "A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16601] "Used specifically for analysis of past, present, or future patterns in technology, economics, and social or developmental processes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16602] "Islands between the Caribbean Sea and the North Atlantic Ocean, northeast of Venezuela. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16603] "Encoded by human TDO2 Gene, 406-aa 48-kDa Tryptophanase is a homotetramer that may bind protoheme IV involved in tryptophan catabolism with broad specificity towards tryptamine and derivatives including tryptophan, 5-hydroxytryptophan, and serotonin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16604] "Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                  
[16605] "A substance sometimes found in an increased amount in the blood, other body fluids, or tissues and which may mean that a certain type of cancer is in the body. Examples of tumor markers include CA 125 (ovarian cancer), CA 15-3 (breast cancer), CEA (ovarian, lung, breast, pancreas, and gastrointestinal tract cancers), and PSA (prostate cancer). Also called biomarker."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16606] "A country in Northern Africa, bordering the Mediterranean Sea, between Algeria and Libya. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16607] "A country in southeastern Europe and southwestern Asia (that portion of Turkey west of the Bosporus is geographically part of Europe), bordering the Black Sea, between Bulgaria and Georgia, and bordering the Aegean Sea and the Mediterranean Sea, between Greece and Syria. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16608] "A country in Central Asia, bordering the Caspian Sea, between Iran and Kazakhstan. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16609] "Two island groups in the North Atlantic Ocean, southeast of The Bahamas. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16610] "An island group consisting of nine coral atolls in the South Pacific Ocean, about one-half of the way from Hawaii to Australia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16611] "A group of copper proteins that also catalyse the reaction of EC 1.10.3.1 catechol oxidase, if only 1,2-benzenediols are available as substrate. (from IUBMB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16612] "Conserved nuclear and cytoplasmic Ubiquitins are synthesized as either a polyubiquitin precursor with head to tail repeats or as a single ubiquitin fused to an unrelated tail protein and are typically involved in selective ATP-dependent nonlysosomal degradation of cellular proteins, histone modification, maintenance of chromatin structure, regulation of gene expression, stress response, and ribosome biogenesis. Ubiquitins often appear to be covalently bound to proteins as a marker for degradation. Ubiquitin-dependent proteolysis by the 26S proteasome plays a pivotal role in cell cycle progression. (NCI)"                                                                                                                                                                                                                                                                                                                                                                 
[16613] "A country in Eastern Africa, west of Kenya. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16614] "A country in Eastern Europe, bordering the Black Sea, between Poland and Russia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16615] "(UL-tra-son-OG-ra-fee) A procedure in which sound waves (called ultrasound) are bounced off tissues and the echoes produce a picture (sonogram)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16616] "(ul-tra- VYE-o-let ray-dee-AY-shun) UV radiation. Invisible rays that are part of the energy that comes from the sun.  UV radiation also comes from sun lamps and tanning beds. UV radiation can damage the skin and cause melanoma and other types of skin cancer. UV radiation that reaches the Earth's surface is made up of two types of rays, called UVA and UVB rays. UVB rays are more likely than UVA rays to cause sunburn, but UVA rays pass deeper into the skin. Scientists have long thought that UVB radiation can cause melanoma and other types of skin cancer. They now think that UVA radiation also may add to skin damage that can lead to skin cancer and cause premature aging. For this reason, skin specialists recommend that people use sunscreens that reflect, absorb, or scatter both kinds of UV radiation."                                                                                                                                                          
[16617] "A country in the Middle East, bordering the Gulf of Oman and the Persian Gulf, between Oman and Saudi Arabia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16618] "A country in Western Europe, comprising islands, including the northern one-sixth of the island of Ireland, between the North Atlantic Ocean and the North Sea, northwest of France. The US State Department considers Guernsey, Isle of Man, and Jersey as separate entities, each with its own code. (from CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16619] "A country in North America, bordering both the North Atlantic Ocean and the North Pacific Ocean, between Canada and Mexico. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16620] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16621] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16622] "Food and Drug Administration (FDA), is one of the agencies of the U.S. Department of Health and Human Services. It assures the safety of foods and cosmetics, and the safety and efficacy of pharmaceuticals, biological products, radiation emitting products, medical devices, and also, animal feed and drugs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16623] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16624] "A division of the Executive Branch of the United States government concerned with overall planning, promoting, and administering programs pertaining to veterans. The Department of Veterans Affairs (VA) was established March 15, 1989 as a Cabinet-level position."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16625] "The inhabitants of a city or town, including metropolitan areas and suburban areas. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16626] "A test that determines the content of the urine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16627] "A drug that dissolves blood clots or prevents them from forming."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16628] "The medical specialty concerned with the study, diagnosis, and treatment of diseases of the genitourinary tract."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16629] "A country in Southern South America, bordering the South Atlantic Ocean, between Argentina and Brazil. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16630] "Encoded by human CDH1 Gene (CDH Family), 882-amino acid 97 kD (precursor) invasion suppressor type I membrane protein E-Cadherin is the main homodimeric Ca(2+)-dependent cell-cell adhesion glycoprotein in non-neural epithelia. Structurally similar to immunoglobulins, E-cadherin contains five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail required for internalization. E-Cadherin acts as ligand for integrin Alpha-E/Beta-7. CDH1 defects cause Familial Gastric Cancer. CDH1 mutations are correlated with breast, colorectal, thyroid, and ovarian cancer. E-cadherin down regulation often correlates with invasive potential and poor prognosis of human carcinomas; it is likely a main event in cancer proliferation, invasion, and metastasis, due to dysfunction of cell-cell adhesion. (from LocusLink, SWISS-PROT, OMIM, and NCI)"                                                                                                  
[16631] "A country in Central Asia, north of Afghanistan. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16632] "A group of islands in the South Pacific Ocean, about three-quarters of the way from Hawaii to Australia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16633] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16634] "An enclave of Rome (Italy). (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16635] "A country in Northern South America, bordering the Caribbean Sea and the North Atlantic Ocean, between Colombia and Guyana. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16636] "RAEB: The practice of medicine as applied to non-human animals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16637] "A country in Southeastern Asia, bordering the Gulf of Thailand, Gulf of Tonkin, and South China Sea, alongside China, Laos, and Cambodia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16638] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16639] "Proteins found in any species of virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16640] "Islands between the Caribbean Sea and the North Atlantic Ocean, east of Puerto Rico. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16641] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16642] "The selecting and organizing of visual stimuli based on the individual's past experience."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16643] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16644] "Islands in the South Pacific Ocean, about two-thirds of the way from Hawaii to New Zealand. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16645] "Restoration of diseased or damaged tissues naturally by healing processes or artificially, as by surgical means."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16646] "Examination of any part of the body for diagnostic purposes by means of roentgen rays, recording the image on a sensitized surface (such as photographic film)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16647] "A type of high-energy radiation.  In low doses, x-rays are used to diagnose diseases by making pictures of the inside of the body.  In high doses, x-rays are used to treat cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16648] "(ZEE-ro-ray-dee-AH-gra-fee) A type of x-ray in which a picture of the body is recorded on paper rather than on film."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16649] "A country in the Middle East, bordering the Arabian Sea, Gulf of Aden, and Red Sea, between Oman and Saudi Arabia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16650] "A republic in Southeastern Europe, bordering the Adriatic Sea, between Albania and Bosnia and Herzegovina. Formerly known as Yugoslavia.  (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16651] "A country in Central Africa, northeast of Angola. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16652] "A country in Southern Africa, east of Angola. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16653] "A country in Southern Africa, between South Africa and Zambia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16654] "The branch of biology dealing with the study of animals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16655] "An enzyme that catalyzes the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the biosynthesis of phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. This pathway is thought to play a critical role in DNA repair, V(D)J recombination and cell cycle checkpoints. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16656] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16657] "A protease involved in clotting"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16658] "The aryl hydrocarbon receptor (AhR) is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. Many foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are ligands of AhR. Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the AhR."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16659] "Encoded by Bone Morphogenetic Protein Genes (TGF Beta Superfamily), 9 structurally related Bone Morphogenetic Proteins are non-collagenous bone-growth regulatory factors synthesized as large precursor molecules that are cleaved by proteolytic enzymes and form an active homodimer or heterodimer of two related bone morphogenetic proteins that stimulate osteogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16660] "Ubiquitous heterodimeric human Calcineurin is Ca(2+)/calmodulin-regulated protein phosphatase involved in many biologic activities as a modifier of phosphorylation status. Composed of widely expressed or tissue-restricted 55-60-kDa calmodulin-binding catalytic subunit (PPP Phosphatase/PP-2B Family) and conserved 19-kD Ca(2+)-sensitive regulatory subunit, Calcineurin appears to regulate glycolytic metabolism, nuclear translocation of NFATC1 transcription factor, sperm motility, and dopaminergic signal transduction and NMDA receptor-dependent synaptic plasticity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                      
[16661] "This protein is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16662] "Cathepsin L, encoded by the CTSL Gene, is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. It is important for the overall degradation of proteins in lysosomes. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. Cathepsin L has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. Cathepsin L is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene. (From LocusLink and NCI)"                                                                                                                                                                                              
[16663] "A constitutively expressed protein in human neutrophils; a 29-kDa glycoprotein with broad spectrum antimicrobial activity and chemotactic activity toward monocytes"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16664] "B cell specific adhesion molecule; active in adhesion to monocytes and T cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16665] "A protein found on the surface of some bone marrow and blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16666] "50 kD glycoprotein expressed on all B cells; plays an important role in B cell development and activation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16667] "This protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. It is specifically expressed in hematopoietic cells. It has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. It also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. (RefSeq)"                                                                                                                  
[16668] "This protein is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16669] "A neuroendocrine product of certain prostate cells.  Adds to the predictive value of prostate specific antigen in the evaluation of men with prostate disease. (from Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16670] "CRE Recombinase catalyses site-specific recombination between two 34 base pair loxp sites and maintains the phage genome as a monomeric unit-copy plasmid in the lysogenic state.  CRE is a homotetramer when bound to DNA and belongs to the phage integrase family.  (from SWISS-PROT P06956 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16671] "Ubiquitously or widely expressed human cAMP Responsive Element Binding Proteins (bZIP/CREB Family) are conserved nuclear bZIP domain dimeric transcription factors that bind to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induce gene transcription in response to cAMP signaling pathways. CREB proteins bind to DNA as a homodimer or a heterodimer with JUN/c-Jun or ATF2/CREBP1. Increased cAMP levels following stimulation activate cAMP-dependent protein kinase A, which phosphorylates CREB proteins that stimulate transcription of cAMP-responsive genes.  Calcium-regulated CREB transcription factors integrate calcium and cAMP signals.  cAMP pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals. (NCI)"                                                                                                                                 
[16672] "This protein is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. (from LocusLink)"                                                                                                                                                                                                                                                     
[16673] "Deoxyguanosine triphosphate (dGTP) triphosphohydrolase (EC 3.1.5.1).  Highly specific for dGTP, producing deoxyguanosine and inorganic tripolyphosphate. (Seto et al, JBC 1988)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16674] "A drug target in the pyrimidine biosynthetic pathway.  Variation in gene expression or sequence may alter the efficacy of chemotherapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16675] "An enzyme involved in pyrimidine catabolism. Increased DPD levels can influence tumor response to 5-fluorouracil-based chemotherapy through increased inactivation of the agent in tumor cells. Increases of the DPD mRNA level in cancerous tissue seem to reflect tumor progression. High DPD mRNA levels in liver metastasis and advanced colorectal cancer may have clinical importance for 5-fluorouracil-based chemosensitivity. (from Ann Surg Oncol 2002;9:599-603)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16676] "Heterodimeric human DNA Primase consists of a 49-kDa (small) and a 58-kDa (large) subunit. Eukaryotic DNA replication involves a replication apparatus containing the key enzymatic components DNA Primase and DNA Polymerase Alpha. DNA Primase is a polymerase that synthesizes small RNA primers for Okazaki fragments made during discontinuous DNA replication. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16677] "Neurotransmission mediated by the Dopamine D2 Receptor (DRD2) plays a key role in the control of movement, in reward and reinforcement mechanisms in psychiatric disorders, and in the neuromodulation of appetitive behaviors.  Acting through D2 dopamine receptors, dopamine specifically inhibits the vascular permeabilizing and angiogenic activities of VEGF by inducing endocytosis of VEGF receptor 2, preventing VEGF binding, receptor phosphorylation, and signaling.(from OMIM 126450 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16678] "There are three signaling VEGF receptors. The VEGF family members PIGF and VEGF-B with exclusive binding capacities to the VEGFR-1 can influence monocyte activation and differentiation. The VEGFR-2 and VEGFR-3 binding VEGF homologues, VEGF-C and VEGF-D, are mitogens for both vascular and lymphatic endothelial cells. The orf virus encoded VEGF-E homologue binds and activates only the VEGFR-2 and thus may be the prototype of a vascular endothelial cell-specific growth factor.  Further specific activities of VEGF and its homologues result from receptor-specific signaling and differential expression of ligands or receptors. A naturally occurring soluble form of the VEGFR-1 suggests a regulatory role for this receptor.(Semin Thromb Hemost 2000;26(5):561-9)"                                                                                                                                                                                                          
[16679] "A 52-kDa, positive DNA-binding transcription factor that interacts with viral and cellular enhancers. AP-2 appears to regulate ectodermal development."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16680] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16681] "A cytochrome P-450 enzyme capable of activating procarcinogenic polycyclic hydrocarbons and halogenated aromatic hydrocarbons into mutagenic compounds. Ethoxyresorufin acts as a substrate for CYP1A1 and measurement of ethoxyresorufin O-deethylase provides a more direct method of detection for this enzyme. EC 1.-."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16682] "Family of receptor tyrosine kinases for fibroblast growth factor. Amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. (On-line Medical Dictionary and RefSeq)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16683] "family of proteins which regulate the activities of Ras proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16684] "Haptoglobin-related protein (trypanosome lytic factor) confers human resistance to Trypanosome brucei.  HPR or HPR-like epitopes are expressed in human breast carcinoma.  Expression of HPR epitopes was associated with earlier recurrence, and multivariate analysis showed that HPR-epitope expression was an independent prognostic factor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16685] "Heparan Sulfate Proteoglycan is an extracellular matrix and vascular basal lamina component. Heparan Sulfate is also an essential co-factor in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions.  Degradation by heparanase is a key step in extravasation by tumor cells and migrating leukocytes, as well as in angiogenesis, wound healing, and smooth muscle proliferation. Degradation by heparanase is a key step in extravasation by tumor cells and migrating leukocytes, as well as in angiogenesis, wound healing, and smooth muscle proliferation. In basement membranes, heparan sulfate may stabilize other molecules and influence glomerular permeability and cell adhesion. (From OMIM 142461 and NCI)"                                                                                                                                                                                                                 
[16686] "Eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-a-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-a-D-gluc-4-enuronosyl groups at their non-reducing ends. (IUBMB Enzyme Nomenclature)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16687] "Class of enzymes that catalyze the acetylation of specific lysine residues of histones, proteins that organize eukaryotic DNA into chromatin.  Among the proteins that exhibit histone acetyltransferase activity are various transcription factor coactivators.  E.C. 2.3.1.48."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16688] "retrovirus encoded protein which covalently links the viral cDNA to host DNA; forms a 'preintegration complex' and catalyzes the viral integration reaction."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16689] "LFA-1 is a receptor for ICAM1, a surface molecule constitutively expressed on some tissues and induced on others in inflammation.  The interaction of LFA-1 with ICAM provides essential accessory adhesion signals in many immune interactions, including those between T- and B-lymphocytes and cytotoxic T-cells and their targets."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16690] "Encoded by Ku Subunit Genes, tightly-associated 70-kDa Ku70 Protein and 80-kDa Ku80 Protein are subunits of heterodimeric DNA-binding Ku Protein, a DNA damage repair complex that, with the 470-kDa catalytic DNA-PKcs subunit forms DNA-dependent protein kinase, binds and repairs double-stranded DNA breaks, facilitates repair by nonhomologous end-joining, and is involved in V(D)J recombination. Ku also binds to DNA ends with a telomere binding protein and mediates telomere capping to prevent fusion of chromosome ends and genetic instability. KU70 and KU80 form a dyad-symmetrical ring molecule that encircles duplex DNA. Ku is identical to DNA helicase II, an ATP-dependent DNA unwinding enzyme. (NCI)"                                                                                                                                                                                                                                                                   
[16691] "Encoded by human LAMR1 Gene (Non-Integrin Family, S2P Family), this 295-amino acid 37-kD protein contains a negative C-terminal segment, amphipathic alpha-helices, and N-glycosylation sites. Identical to 40S Ribosomal Protein SA, the heterodimeric 67-kD Laminin Receptor-1 is a conserved multifunctional protein involved in translation and cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis. Expression in cancer cells correlates with invasive/metastatic phenotype.  (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                
[16692] "The Type V intermediate filaments have a nuclear signal sequence and form a filamentous support inside the inner nuclear membrane. Their assembly and disassembly into the lamina is controlled through the cell cycle by phosphorylation and interactions with additional proteins and nuclear structures. Lamins are vital to the re-formation of the nuclear envelope after cell division and vital to the re-formation of the nuclear envelope after cell division."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16693] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16694] "A protein tyrosine kinase activated within seconds after crosslinking the mIg complex on B cells or the TCR on T cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16695] "Members of the G protein-coupled superfamily of receptors.  Two pharmacologically distinct high affinity melatonin receptors have been identified, Mel1 and Mel2, and Mel1 class receptors Mel1A, Mel1B, and Mel1C have been cloned.  Transduce signals via at least two pathways, one inhibiting adenylyl cyclase and the other regulating phospholipide metabolism and calcium concentration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16696] "A flavoprotein (FAD).  [EC 1.5.1.20 created 1978 as EC 1.1.1.171, transferred 1984 to EC 1.5.1.20] (from IUBMB)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16697] "Highly expressed as 4 alternative isoforms in kidney and sweat glands by human NR3C2 Gene (NR3 Family), ubiquitous phosphorylated Mineralocorticoid Receptor contains an N-terminal modulating domain, a DNA-binding domain, and a C-terminal steroid (mineralocorticoid/glucocorticoid)-binding domain. Absent ligand, NR3C2 resides in a heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4 or with HSD11B2 in the ER membrane. Ligand-activated NR3C2 translocates to the nucleus, binds to DNA mineralocorticoid response elements as a homodimer or heterodimer with NR3C1, and transactivates target gene expression, which increases ion and water transport; raises extracellular fluid volume and blood pressure; and lowers potassium levels. NR3C2 appears to bind NCOA1, NCOA2, TIF1, and NRIP1. NR3C2 defects cause PHA1 and early onset hypertension. (NCI)"                                                                                                           
[16698] "Active in neural crest cells during development and expressed primarily in neuroectodermal lineages and vascular smooth muscle in adult tissues by human MCAM Gene (Ig Superfamily), 646-aa 72-kDa (precursor) Melanoma Adhesion Molecule is a cell surface type I membrane glycoprotein containing 3 Ig-like C2-type domains and 2 Ig-like V-type domains and a possible adhesion molecule homologue of cell adhesion molecule NCAM. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16699] "Nucleoside Diphosphate Kinase A (NM23) activity is correlated with inhibition of metastasis; low NM23 levels are associated with high metastatic potential.  NM23 has sequence homology with the developmentally related Drosophila awd protein.  NM23 may be a transcription factor for the MYC oncogene.  PuF (NM23) binds to a nuclease-hypersensitive element of the MYC P1 promoter and is necessary for efficient P1 and P2 transcription initiation.  A murine homologue of NM23 is a differentiation inhibiting factor in myeloid cells.  (from OMIM 156490 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                       
[16700] "Encoded by human MGMT Gene (MGMT Family), 207-aa 22-kDa O-6-Methylguanine-DNA Methyltransferase is a unique and ubiquitous DNA repair enzyme that acts on alkylated guanine and other methylated DNA moities. O(6)-alkylguanine is the major mutagenic and carcinogenic adduct lesion in DNA, induced by simple alkylating mutagens because of its preference for pairing with thymine during DNA replication. Unlike true enzymes, MGMT accepts the O-6 alkyl group from the lesion to a cysteine acceptor residue in the enzyme repairing the alkylated DNA in a stoichiometric second-order suicide reaction; the enzyme is irreversibly inactivated. (NCI)"                                                                                                                                                                                                                                                                                                                                     
[16701] "DBL protein is a cytoplasmic guanine nucleotide exchange factor serine phosphoprotein distributed between cytosol and crude membrane fractions.  Over expression of DBL is sufficient to transform NIH 3T3 cells.  Oncogenic activation of the DBL gene occurs through substitution of part of its 5-prime coding region by unrelated non-syntenic sequences.  The upstream replacing sequence is derived from the D15S93 locus on human chromosome 15.  (from OMIM 311030 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16702] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16703] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16704] "Proto-oncogene ERBB2 encodes a putative tyrosine kinase growth factor receptor EGFR2, p185 HER2/NEU antigen, similar to the EGF receptor.  The ERBB2, ERBB3, and ERBB4 proto-oncogenes encode heregulin/neuregulin receptors, members of the EGFR-related type I receptor tyrosine kinase subfamily.  The encoded proteins form homo- and heterodimers, which complicates assignment of function: ERBB2 homodimers do not bind heregulin, but ERBB2/ERBB3 heterodimers do.  Herstatin is a secreted alternative ERBB2 product, of the extracellular domain, that binds to p185ERBB2, disrupts ERBB2 dimers, reduces p185 phosphorylation, and inhibits growth.  Human ERBB2 gene is located at 17p12-21.  Overexpression of HER-2 correlates with poor prognosis in breast carcinoma."                                                                                                                                                                                                              
[16705] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16706] "High affinity cellular receptor for urokinase plasminogen activator (uPA).  Plays a role in plasminogen activation by facilitating the conversion of uPA to an enzymatically active form anchored to the cell membrane, where plasminogen activation occurs.  Affects tissue remodeling (surface proteolysis, cell adhesion, cell migration), and cancer invasion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16707] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16708] "This protein is found in the nucleus and is a cofactor of DNA polymerase delta. It acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16709] "A member of the serpin family of proteins that is found in plasma and urine. It is dependent on heparin and able to inhibit activated protein C, thrombin, kallikrein, and other serine proteinases. (MSH99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16710] "A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16711] "aka p53/56LYN.  A protein tyrosine kinase activated within seconds after crosslinking the mIg complex on B cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16712] "Cellular proteins encoded by the c-mos genes (GENES, MOS). They function in the cell cycle to maintain MATURATION PROMOTING FACTOR in the active state and have protein-serine/threonine kinase activity. Oncogenic transformation can take place when c-mos proteins are expressed at the wrong time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16713] "A protein on the surface of some cells that binds to stem cell factor (a substance that causes certain types of cells to grow).  Altered forms of this receptor may be associated with some types of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16714] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16715] "Expressed in breast, pancreas, stomach, and gastrointestinal epithelium, estrogen-responsive human TFF1 Gene (Trefoil Family) encodes cysteine-rich secretory 84-aa 9-kD (precursor) PS2 Protein, a likely tumor suppressor containing one P-type trefoil domain and a 40-aa domain with three conserved disulfides. TFF1 appears to play a complex repressor role in cell progression towards S phase (G1/S transition) and in apoptosis; TFF1 may promote cell differentiation and tissue repair. TFF1 may protect the gastrointestinal mucosa from insults, stabilize the mucus layer, and affect epithelial healing; strong expression is found in GI tract regenerative tissues. The exact function of TFF1/PS2 has not yet been determined. (NCI)"                                                                                                                                                                                                                                            
[16716] "RHO B protein is a GTP-binding protein involved in a signal transduction pathway that controls assembly of focal adhesions and actin stress fibers.  Rho regulates remodeling of the actin cytoskeleton during cell morphogenesis and motility.  Active Rho signals to its downstream effector ROCK1, which phosphorylates and activates LIM kinase.  LIM kinase, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.  (from OMIM 165370 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16717] "A family of soluble proteins that bind insulin-like growth factors and modulate their biological actions at the cellular level.  Serum IGFBP levels have been found to be negatively correlated to the risk of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16718] "Cell surface proteins that bind somatostatin and trigger intracellular changes which influence the behavior of cells. Somatostatin receptor scintigraphy has been one of the most important diagnostic tools for staging of Neuroendocrine gastrointestinal tumors and also indicating sensitivity to treatment with somatostatin analogues.  This marker can be used for diagnosis and follow-up of the patients. (from Ann Oncol 1999;10 Suppl 2:S3-8)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16719] "A small bacterial protein that binds with high affinity to the vitamin biotin. This streptavidin-biotin combination can be used to link molecules such as radioisotopes and monoclonal antibodies together. These bound products have the property of being attracted to, and attaching to, cancer cells, rather than normal cells. The radiolabeled products are more easily removed from the body, thus decreasing their toxicity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16720] "The syndecans are a family of cell-surface heparan sulphate proteoglycans that regulate cell behavior by binding extracellular matrix molecules such as growth factors. The syndecan family has four members, of which syndecan-1 is the most studied and best characterized.  In squamous cell carcinoma of the head and neck low syndecan-1 expression has been associated with unfavorable overall survival and can be used as a prognostic factor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16721] "CD28 encodes a highly glycosylated membrane protein with homology to the Ig superfamily.  It also shares significant sequence identity with CTLA-4.  Both bind the same ligands, however CTLA-4 binds to B7 with a greater affinity.  B7 antigen-presenting cells regulate T-cell activation by delivering antigen-independent stimulatory signals through CD28 and inhibitory signals through CTLA-4.  CD28 is found on the membrane of resting T-cells.  Posttranslational processing appears to result in variant isotypes of CD28 with potentially different physiologic roles on the cell surface.  CD28 undergoes tyrosine phosphorylation after interacting with its ligand, B7.  Phosphorylation in the cytoplasmic domain of CD28 allows the recruitment of signaling proteins such as PI3K, GRB2, and GADS via their SH2 domains.  (from OMIM 186760 and NCI)"                                                                                                                            
[16722] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16723] "Tenascin (hexabrachion, cytotactin) is an extracellular matrix protein that promotes cell attachment with spatially and temporally restricted tissue distribution in many developing organs.  It is a hexameric, multidomain protein with disulfide-linked subunits.  A C-terminal domain is similar to fibrinogen.  Tenascin also contains type III units, similar to those in fibronectin, and EGF-like repeats.  In the CNS, tenascin C is expressed primarily by astrocytes.  Tenascin expression is induced by serum as well as TGF-beta.  (from OMIM 187380 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                         
[16724] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16725] "Topoisomerase III belongs to type IA topoisomerases subfamily (includes archaebacterial reverse gyrase, bacterial topo I and topo III, which all form covalent 5'phosphotyrosine linkage with cleaved DNA).  Topo III does not play a major role in regulating DNA supercoiling, however, genetic experiments implicate that it plays a role in suppressing mitotic recombination and in resolving recombined homologous chromosomes during meiosis I. Topo III also has been demonstrated to interact with RecQ family of DNA helicases, which includes the Bloom's syndrome, Werner's syndrome, and Rothmund-Thomson syndrome gene products."                                                                                                                                                                                                                                                                                                                                                     
[16726] "The cell surface binding proteins for tumor-derived growth factor- beta. There are three receptors, Type I and Type II together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. Type III is a transmembrane proteoglycan with a large extracellular domain and a cytoplasmic domain that lacks an obvious signaling motif."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16727] "Nerve growth factor receptor (NGFR) is also referred to as p75(NTR) due to its molecular mass and its ability to bind at low affinity not only NGF, but also other neurotrophins, including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NTF3), and neurotrophin-4/5 (NTF5). NGFR was the first member of the large superfamily of tumor necrosis factor receptors. The identification of this superfamily helped elucidate some of the biologic functions of NGFR, including its ultimate involvement in the nuclear factor kappa-B (NFKB) and apoptosis pathways. As a monomer, NGFR binds NGF with low affinity. Higher affinity binding is achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1), TRKB (NTRK2), and TRKC (NTRK3). (OMIM)"                                                                                                                                                 
[16728] "Troponin I, troponin T, and troponin C are the three closely associated subunits of the troponin complex of thin filaments in muscle.  The complex serves as a calcium-sensitive switch that regulates muscle contraction.  In the absence of calcium, Troponin I binds actin, inhibits actomyosin ATPase activity, and inhibits F-actin-myosin interactions.  The troponin I gene family comprises three isoforms: skeletal TNI-fast, skeletal TNI-slow, and TNI-cardiac.  (from OMIM 191044, 191043, 191042 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16729] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16730] "Neurohypophyseal vasopressin is a cyclic nonapeptide involved in diverse actions, including the control of body fluid osmolality, blood volume, blood pressure, vascular tone, hepatic glycogenolysis, vascular smooth muscle and mesangial cell contraction, nephric antidiuresis, and platelet aggregation.  Vasopressin binds to three GPCR subtypes: V1A, V1B, and V2.  The V1A receptor is located in liver, vascular smooth muscle, brain, mesangial cells, and platelets.  It mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor, and glycogenolysis.  V1A and V1B activate PLC via Gq/11, which increases intracellular calcium.  Arginine VP modulates ACTH, beta-endorphin, and prolactin release, mediated by V1B.  V2 is expressed exclusively in the kidney and mediates the antidiuretic effect of arginine VP by activating adenylyl cyclase via interaction with Gs.  (from OMIM 600821, 600264, and NCI)"                            
[16731] "The ABL1 gene (ABL family) at 9q34.1 encodes a ubiquitous 145 kD nuclear/cytoplasmic non-receptor protein tyrosine kinase implicated in cell differentiation, division, adhesion, and stress response. ABL1 plays a role in myeloid hematopoiesis. Alternatively spliced exon 1a specifies nuclear ABL1 that enhances target gene transcription. ABL nuclear activity is regulated by CDC2 phosphorylation and by RB1. RB inhibits the ABL kinase. ABL transactivates the p73 gene and phosphorylates the p73 substrate. Alternatively spliced exon 1b encodes myristylated, plasma membrane-associated ABL1. PEST phosphatases negatively regulate ABL and PSTPIP1 is an ABL substrate. The ABL SH3 domain negatively regulates its kinase activity. The N-terminus mediates autoregulation and its loss is oncogenic. Fused BCR-ABL oncogenes are responsible for CML, AML, and ALL. (NCI)"                                                                                                       
[16732] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16733] "RAEB: Cytological screening test for cervical cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16734] "family of proteins which accumulate during interphase of the eukaryotic cell cycle and are destroyed at the conclusion of mitosis; believed to be involved in inducing mitosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16735] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16736] "Encoded by Extracellular Matrix Protein Genes, Extracellular Matrix Proteins are mostly fibrous proteins (e.g., Collagen, Elastin, Fibronectins, and Laminin) typically located in the Extracellular Matrix and commonly involved in cell attachment, cell movement, cell growth, morphogeneseis, organogenesis, and tissue repair, architecture, and organization. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16737] "4D; Clinical Health Services Research And Delivery; Research"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16738] "Selection and deposition of individual cells of a particular phenotype from a mixed population into a separate tube or tissue culture plate by the use of a fluorescence-activated cell sorter (FACS) and fluorescently-labeled antibodies specific for surface molecules on the cells to be sorted."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16739] "A type of mutation in which one or more paired nucleotides are inserted or deleted in the coding region of a gene, which causes the triplet codons to be read in the wrong frame; the resulting polypeptide has a garbled amino acid sequence from the mutated codon on. (Life Sciences Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16740] "Phase of the cell cycle preceding DNA synthesis (Gap 1 phase). The subphases of G1 include competence, entry (G1a), progression (G1b), and assembly (G1c), based on the effects of limiting growth factors, nutrients, or inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16741] "Phase of the cell cycle following DNA synthesis and preceding mitosis (Gap 2 phase). The chromosomes are tetraploid in this phase."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16742] "Gender is the assemblage of properties that distinguish people on the basis of their societal roles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16743] "Isolated as a gene in a region frequently deleted in colorectal carcinomas, the DCC gene encodes a protein with sequence similarity to cell adhesion molecules such as N-CAM and may participate with other proteins in cell-cell and cell-matrix interactions. It is a transmembrane protein of the immunoglobulin superfamily, is expressed on spinal commissural axons and possesses netrin-1-binding activity. Knockout studies in mice failed to support a tumor-suppressor function for DCC in the mouse, but were consistent with the hypothesis that DCC is a component of the receptor for netrin-1, a neuronal chemoattractant. (from OMIM)"                                                                                                                                                                                                                                                                                                                                              
[16744] "A tumor suppressor gene that normally inhibits the growth of tumors. This gene is altered in many types of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16745] "Cloned gene for Hereditary Retinoblastoma. The results of many experiments indicate that the normal function of the RB gene product is a negative regulator of cellular proliferation which is achieved by sequestering a variety of nuclear proteins involved in cellular growth. Other experiments indicate that the RB protein acts as a transcriptional repressor by targeting the E2F transcription factors, whose functions are required for entry into S phase.(from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16746] "The genes coding for the Regulator X (rex) protein of HTLV-I and II.  The Rex phosphoprotein binds to a cis-acting Rex response element in the RNA transcript.  It is required for the nuclear export of unspliced viral RNA, and therefore essential for packaging of the RNA in virions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16747] "(TOO-mer) Genes in the body that can suppress or block the development of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16748] "The genes coding for the Trans-Activator X (tax) protein of HTLV-I and II.  Tax activates transcription via interactions with the ATF/CREB transactivator(s) and the CBP/p300 coactivators which assemble as a multiprotein complex on the 21-bp repeat elements in the proviral LTR.  Tax also modulates expression of cellular genes via the ATF/CREB and NF-kappaB pathways."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16749] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16750] "Rex gene of the HTLV-I virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16751] "Tax gene of the HTLV-I virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16752] "Rex gene of the HTLV-II virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16753] "Tax gene of the HTLV-II virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16754] "Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16755] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16756] "L-MYC Protein belongs to the bZIP family of transcription factors and demonstrates multiple discrete regions of extensive homology to MYC and N-MYC.  L-MYC binds DNA as a heterodimer with MAX; efficient DNA binding requires dimerization with another bHLH protein.  The gene sequence is amplified 10- to 20-fold in the DNA of small-cell lung cancer (SCCL).  Several L-MYC mRNAs are produced in SCCL cells from a single gene by alternative splicing and use of alternative polyadenylation signals.  (from OMIM 164850, Swiss-Prot P12524, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16757] "Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAL encodes the integrin alpha L chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                               
[16758] "An adhesion-promoting leukocyte surface integrin heterodimer contains an alpha subunit of CD11b antigen and a beta subunit of CD18 antigen.  The heterodimer functions as a receptor for complement 3, and in cell-cell and cell-substrate adhesive interactions.  Major surface antigens on leukocytes include CR3A, LFA-1, and p150,95, which share a common beta chain linked to one of three alpha distinctive chains.  They promote adhesion of granulocytes to each other and to endothelial cells.  The CR3A alpha subunit (CD11b) is homologous to the alpha subunit of IIb/IIIa, a platelet glycoprotein that also serves adhesive functions.  CD11b also exhibits significant homology with portions of the alpha subunits of fibronectin, vitronectin, platelet IIb/IIIa receptors, and p150,95.  The protein consists of an N-terminal extracytoplasmic domain, a transmembrane segment, and a short C-terminal cytoplasmic domain.  (from OMIM and NCI)"                               
[16759] "Electron microscopy in which a very sharp conducting needle is swept just a few angstroms above the surface of a sample. The tiny tunneling current that flows between the sample and the needle tip is measured and from this are produced three-dimensional topographs, with a lateral resolution often as good as 1-2 angstroms and a vertical resolution of less than 1 angstrom. Due to their composition, biological samples are usually coated with a conductive layer, e.g., by depositing a thin metal or carbon film on top of the sample, to enhance their conductivity. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                        
[16760] "Acquired defect of cellular immunity that occurs in mice infected with mouse leukemia viruses (MuLV). The syndrome shows striking similarities with human AIDS and is characterized by lymphadenopathy, profound immunosuppression, enhanced susceptibility to opportunistic infections, and B-cell lymphomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16761] "Production of genetic alterations by any technique, including chemicals, radiation, recombination, or other molecular biology methods."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16762] "Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16763] "Mutagenesis where the mutation is caused by in vitro induction directed at a specific site in a DNA molecule. The most common method involves use of a chemically synthesized oligonucleotide mutant which can hybridize with the DNA target molecule. The resulting mismatch-carrying DNA duplex may then be transfected into a bacterial cell line and the mutant strands recovered. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16764] "The MYCN oncogene is amplified in approximately 25% of neuroblastoma tumors and is the most significant negative prognostic factor. In neuroblastoma, the MYCN oncogene directly activates genes required for DNA replication, and this may contribute to neoplastic transformation of these MYCN-amplified tumors. Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma. (from PMID 11861392 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16765] "NF-kB is a heterodimer complex of two DNA-binding subunits from two families of ubiquitous, inducible, nuclear transcription activators involved in cytokine-induced activation of gene expression.  NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-kB complex. NF-kB is inhibited by IkB proteins (NFKBIA or NFKBIB), which inactivate NF-kB by trapping it in the cytoplasm.  Phosphorylation of IkB by kinases (IKBKA or IKBKB) marks them for ubiquitination, allowing NF-kB translocation to the nucleus and DNA binding at kappa-B transcription enhancer motifs.  In B-lymphocytes, NF-kB binds to the immunoglobulin kappa light chain enhancer and in T-lymphocytes it binds to enhancers in virally infected cells, including HIV.  (from OMIM 164011, 164012, 164910, 164014, 604758, and NCI)"                                                                                                                                                                            
[16766] "The promotion and maintenance of physical and mental health in the work environment. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16767] "p21 H-RAS protein is encoded by the H-RAS gene.  RAS proteins are involved in transmembrane signal transduction as monomeric GTP-binding proteins, with intrinsic GTPase activity, that alternate between an inactive GDP-bound form and an active GTP-bound form.  RAS proteins are activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein.  Mitogen-stimulated RAS enhances MYC accumulation by stabilizing MYC protein.  This stabilization is dependent on the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC.  Mutations of specific amino acids activate c-RAS to transform cells and are implicated in a variety of human tumors.  Allelic deletions of HRAS are correlated with progression and metastasis of carcinomas and sarcomas.  (from OMIM 190020, SWISS-PROT P01112, and NCI)"                                                                                                               
[16768] "p21 K-RAS protein is encoded by the K-RAS gene.  Two KRAS isoforms are produced by alternative splicing.  RAS proteins are involved in transmembrane signal transduction as monomeric GTP-binding proteins, with intrinsic GTPase activity, that alternate between an inactive GDP-bound form and an active GTP-bound form.  RAS proteins are activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein.  Mitogen-stimulated RAS enhances MYC accumulation by stabilizing MYC protein.  This stabilization is dependent on the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC.  Mutations of specific amino acids activate c-RAS to transform cells and are implicated in a variety of human tumors.  KRAS is involved in malignancy much more often than is HRAS.  (from OMIM 190070, SWISS-PROT P01116, P01118, and NCI)"                                                                                      
[16769] "p21 N-RAS protein is encoded by the N-RAS gene.  RAS proteins are involved in transmembrane signal transduction as monomeric GTP-binding proteins, with intrinsic GTPase activity, that alternate between an inactive GDP-bound form and an active GTP-bound form.  RAS proteins are activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein.  Mitogen-stimulated RAS enhances MYC accumulation by stabilizing MYC protein.  This stabilization is dependent on the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC.  Mutations of specific amino acids activate c-RAS to transform cells and are implicated in a variety of human tumors.  (from OMIM 164790, SWISS-PROT P01111, and NCI)"                                                                                                                                                                                                                     
[16770] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16771] "A serine/threonine protein kinase subunit of the M-phase promoting factor complex, required for entry into S-phase and mitosis. A member of the CDC2/CDKX subfamily, p34(cdc2) forms a complex with a Cyclin, and phosphorylates RNA Polymerase II.  CDC2 gene expression is transcriptionally regulated and phosphorylation regulates cdc2 activity. (from SWISS-PROT P06493, OMIM 116940, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16772] "A homo-tetrameric, DNA-binding, trans-activator of genes involved in cell division. p53 induces growth arrest or apoptosis and is mutated or inactivated in about 60% of cancers. JNK-p53 and mdm2-p53 complexes regulate ubiquitination and degradation of p53. (from SWISS-PROT P04637, OMIM 191170, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16773] "Cellular protein encoded by the RAS genes. The protein has intrinsic GTPase activity and is involved in transmembrane signal transduction as a guanine nucleotide binding protein. Elevated levels of p21 c-ras have been associated with neoplasia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16774] "pp60src; phosphoprotein p60src.  Membrane-associated tyrosine-specific kinase encoded by the c-src genes. It has an important role in cellular growth control. Truncation of carboxy-terminal residues in pp60(c-src) leads to pp60(v-src) which has the ability to transform cells. This kinase pp60 c-src should not be confused with csk, also known as c-src kinase. EC 2.7.1.-. (from MSH99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16775] "ABL1 tyrosine kinase has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1 tyrosine kinase. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                           
[16776] "Product of the c-myc proto-oncogene.  A nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16777] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16778] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16779] "RB protein regulates cell proliferation by inhibiting cell cycle progression in G1.  This function involves a complex interaction with other proteins, such as E2F, MYC, TGFB, p16(INK4A), CDK4/CDK6, transcription factor DRTF1, and MDM2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16780] "Phase of the cell cycle following G1 and preceding G2 when the entire DNA content of the nucleus is replicated (Synthesis phase). It is achieved by bidirectional replication at multiple sites along each chromosome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16781] "short, single-copy, genomic DNA sequences spaced at intervals of about 100 kb, used as landmarks to identify the physical origin (chromosomal position) of any clone (gene) of interest; touted as the new \"lingua franca\" of genome mapping."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16782] "An oncogene found in the Abelson strain of mouse leukemia virus and involved in the Philadelphia chromosome translocation in chronic granulocytic leukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16783] "Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16784] "The concept covering the physical and mental conditions of women. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16785] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16786] "A MYB family transcription factor, B-MYB Protein is essential during cell cycle progression; MYBL2 activates CDC2 and cyclin D1 gene expression in proliferating fibroblasts.  MYBL2 expression is regulated at the G1/S transition, and its transcription relies on E2F activity in a cell cycle-dependent manner.  MYBL2 transcripts are detectable in a variety of dividing cell types.  (from OMIM 601415 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16787] "A cell adhesion molecule present on virtually all monocytes, platelets, and granulocytes, CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.  An integral membrane glycoprotein that contains six extracellular Ig-like domains, one transmembrane domain, and a cytoplasmic domain, CD31 is most similar to the CAM subgroup of the Ig superfamily.  PECAM1 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation.  Ig superfamily members mediate cell adhesion, or antigen recognition, T-cell receptors, and MHC molecules.  A subgroup contains one or more cytoplasmic ITIM motifs.  PECAM1 has six ITIMs and may serve as a negative regulator of platelet-collagen interactions that may limit growth of platelet thrombi on collagen surfaces.  (from OMIM 173445 and NCI)"                                                                                             
[16788] "Lymphocyte Function-Associated Antigen-3 (LFA-3), encoded by the CD58 gene, is a member of the Ig gene superfamily and a ligand for CD2 via heterophilic adhesion between the N-terminal domains. LFA-3 glycoproteins have a wide distribution on hematopoietic and non-hematopoietic cells and are strongly expressed on macrophages. Interaction between CD2 and its counter-receptor, LFA-3, on opposing cells optimizes immune recognition, facilitating contacts between helper T-lymphocytes and antigen-presenting cells as well as between cytolytic effectors and target cells. (from OMIM 153420 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                
[16789] "Expression of CD72 is restricted to B-lineage cells and is turned off in differentiated antibody-secreting plasma cells.  CD72 may participate in signals for B-cell proliferation and differentiation.  In the immune system, CD72 appears to be a receptor for leukocyte activation antigen, CD100.  CD72 may also be the ligand for CD5, a receptor that regulates T-cell proliferation.  (from OMIM 107272, SWISS-PROT P21854, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16790] "Topoisomerase IV belongs to type II topoisomerase family (includes bacterial DNA gyrase, and eukaryotic topo II).  The type II enzymes are multisubunit proteins, and require ATP for overall catalytic activity. Topoisomerase IV (is a potent decatenase) is required to untangle daughter chromosomes following replication."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16791] "Endoglin is a Transforming Growth Factor Receptor present on tumor vasculature.  It is a marker of angiogenesis and a target for cancer therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16792] "The nuclear Ecotropic Virus Integration Site 1 Protein may interact with CTBP1 and is involved in chronic myelogenous leukemia by a chromosomal translocation t(3;21)(q26;q22) that involves EVI1 and AML1.  (from Swiss-Prot Q03112 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16793] "Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases activated in response to a variety of extracellular stimuli and encoded by a multigene family. The MAPKs are part of complex protein kinase cascades. One class of MAPKs includes (among other ERKs) the extracellular signal-regulated kinases ERK1 (p44MAPK) and ERK2 (p42MAPK), activated by the RAF/MEK/ERK signaling pathway. ERK1/2 are widely involved in eukaryotic signal transduction. Upon activation, ERKs translocate to the nucleus and phosphorylate nuclear targets. Phosphorylated ERKs form essential dimers with phosphorylated and unphosphorylated ERK partners. Dimerization is part of the mechanism of MAP kinase family action. Mitogen-activated protein kinases (MAPKs) promote entry in the cell cycle.  (from OMIM 601795, Swiss-Prot P27361, and NCI)"                                                                                                                                 
[16794] "A class of immunosuppressant binding proteins (immunophilins) specific for FK506 (tacrolimus) and rapamycin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16795] "GLI3 Protein is a putative zinc finger DNA-binding transcription factor of the GLI-Kruppel family.  GLI3 is homologous to Drosophila Cubitus interruptus (Ci), which regulates patched, gooseberry, and decapentaplegic genes.  In response to hedgehog signaling, the full-length cytoplasmic transcriptional activator form of Ci can be cleaved to a nuclear transcription repressor form.  Based on GLI3 mutations and phenotypes, GLI3 shows transcriptional activation or repression, and subcellular localization, similar to Ci.  Cytoplasmic GLI3 activates PTCH gene expression.  PKA-dependent processing of vertebrate GLI3 in the developing limb generates the repressor form, which appears to be antagonized by sonic hedgehog signaling.  Mutations of GLI3 may be responsible for Greig Cephalopolysyndactyly Syndrome, Pallister-Hall Syndrome, and Postaxial Polydactyly, suggesting specific roles during development.  (from OMIM 165240 and NCI)"                            
[16796] "KGF is a potent mitogenic paracrine mediator of epithelial cell proliferation. The keratinocyte growth factor receptor is a FGFR RTK family member with three extracellular Ig-like domains, a single membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. Two alternatively spliced FGFR2 gene products, KGFR and BEK, vary in sequence within the third extracellular Ig loop, which influence ligand-binding characteristics. Control of these alternative splice sites is thought to involve transacting factors. These receptors also have different patterns of expression. KGFR appears to have a role in skin development; BEK is preferentially expressed in osteogenesis. Dimerization of the FGFR2 ectodomain is induced by binding to FGF1 and a heparin decasaccharide, essential in FGF signaling. (from OMIM 176943 and NCI)"                                                                                                                                        
[16797] "The 250 kD neurofibromin product, encoded by the tumor suppressor NF1 gene, is thought to restrict cell proliferation by functioning as a RAS-specific GTPase-activating protein.  NF1 contains a GAP-related domain that down regulates p21(RAS) by stimulating its GTPase activity.  NF1 protein is found in all tissues in a large complex and may be associated with the intermediate filament cytoskeleton.  NF1 gene expression is most abundant in the adult nervous system; neurofibromin may act as a negative regulator of neurotrophin-mediated signaling.  NF1 mutations are associated with neurofibromatosis type I.  (from OMIM 162200 and NCI)"                                                                                                                                                                                                                                                                                                                                     
[16798] "Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. (from LocusLink)"                                                                                                                                                        
[16799] "Containing SH2 and SH3 homology domains that interact with ABL, the tumor suppressor CRK protein appears to be a protein involved in signal transduction.  (from OMIM 164762 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16800] "RHO A GTP-binding protein is involved in regulating signal transduction pathways that control assembly of focal adhesions and actin stress fibers.  Rho regulates remodeling of the actin cytoskeleton during cell morphogenesis and motility.  Active Rho signals to its downstream effector ROCK1, which phosphorylates and activates LIM kinase.  LIM kinase, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.  (from OMIM 165390 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16801] "RHO C protein is a product of the ARHC gene that regulates remodeling of the actin cytoskeleton during cell morphogenesis and motility.  Rho C enhances metastasis when over expressed, whereas a dominant-negative Rho inhibits metastasis.  Analysis of the phenotype of cells expressing dominant-negative Rho C indicates that Rho C is important in tumor cell invasion.  (from OMIM 165380 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16802] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16803] "A probable positive hematopoietic transcriptional regulator, TAL1 belongs to the bHLH family and binds DNA as a hetero-dimer with E12 and E47, which recognize the enhancer E-box DNA motif (5'-CANNTG-3'). TAL1 also binds Rhombotin-2 and DRG1. Some T-ALL leukemias involve TAL1 and TCRA gene translocations, t(1;14)(p32;q11). (from SWISS-PROT P17542, OMIM 187040, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16804] "A nuclear protein that may regulate transcription through control of chromatin structure. SPT6 contains a highly acidic region, a degenerate SH2 domain, and a leucine zipper. (from OMIM 601333 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16805] "PEA3 is a member of the ETS-related transcription factor family and contains a DNA-binding ETS domain and an N-terminal acidic domain. PEA3 appears to bind to the core consensus sequence GGAA recognized by other ETS proteins. PEA3 is widely expressed (though not in normal lymphocytes) and is especially high in brain and placenta.  (from OMIM 601600 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16806] "The parental CHO cell line initiated from a biopsy of an ovary of an adult Chinese hamster."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16807] "a ubiquitous tissue culture model for nontransformed animal cells; derived from nonneoplastic immortalized fibroblasts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16808] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16809] "NF1 encodes the protein neurofibromin, which appears to be a negative regulator of the ras signal transduction pathway. In addition to type 1 neurofibromatosis, mutations in NF1 can also lead to juvenile myelomonocytic leukemia. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16810] "Expressed in kidney, lung, breast, ovary, and fetal brain, human NF2 Gene (ERM family) at 22q12.2 encodes two isoforms of Merlin, similar to ERM proteins that may link cytoskeleton and cell membrane.  LIF and NFH map to the NF2 region.  Merlin may maintain cytoskeletal organization or act as a membrane stabilizing protein.  It contains a band 4.1-like domain and binds to EBP-50, an ERM-interacting phosphoprotein.  Merlin interacts with HRS, an HGF-regulated tyrosine kinase substrate.  The conserved FERM domain and C-terminus may contain key functional domains.  NF2 defects result in neurofibromatosis 2.  Mutant proteins alter cell adhesion, a possible step in NF2 pathogenesis.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                    
[16811] "field-inversion electrophoresis for resolving large DNA molecules (10-2000 kb); involves periodic inversion of a homogeneous electric field in a conventional electrophoresis chamber."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16812] "Discontinuation of the habit of smoking."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16813] "Encoded by human GPI Gene (GPI Family), Glucose-6-Phosphate Isomerase, Neuroleukin, and Autocrine Motility Factor function in different capacities. In glycolysis and gluconeogenesis, homodimeric cytoplasmic GPI catalyzes reversible G6P and F6P isomerization. Produced by lectin-stimulated T-cells, secreted non-mitogenic NLK lymphokine acts early in antibody-secreting cell formation to induce Ig secretion. Also a neurotrophic factor for spinal and sensory neurons, NLK exhibits GPI activity. AMF is a 558-amino acid 55-kD autocrine motility polypeptide. The gene product is partly homologous to a conserved region of HTLV-III-LAV external envelope protein. Gene defects cause nonspherocytic hemolytic anemia and hydrops fetalis. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                             
[16814] "A neural network is a computer algorithm to solve non-linear optimisation problems. The algorithm was derived in analogy to the way the densely interconnected, parallel structure of the brain processes information."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16815] "Encoded by a single human tumor suppressor VCL Gene, Vinculin contains 1,066 amino acids with strong similarity to other vinculins and alpha-catenins. Alternative splice product metavinculin contains additional 68-79 variable and highly conserved amino acids near the C-terminus. Involved in cell adhesion, vinculin is associated with the cytoplasmic face of adherens-type junctions and involved in anchoring F-actin to the plasma membrane. Vinculin is phosphorylated on serines, threonines and tyrosines and is acylated by myristic acid and/or palmitic acid. Vinculin exhibits self-association properties and appears to be the major talin-binding protein in platelets; 150 kD metavinculin also interacts strongly with talin.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                      
[16816] "A major core protein of the human immunodeficiency virus encoded by the HIV gag gene. HIV-seropositive individuals mount a significant immune response to p24 and thus detection of antibodies to p24 is one basis for determining HIV infection by ELISA and Western blot assays. The protein is also being investigated as a potential HIV immunogen in vaccines. (MSH2000)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16817] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16818] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16819] "transfers glycosyl groups."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16820] "PC-12 adheres poorly to plastic, and tends to grow in small clusters. Attachment is improved by using collagen coated flasks."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16821] "An imaging procedure in which antibodies labeled with radioactive substances are given to the person. A picture is taken of sites in the body where the antibody localizes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16822] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16823] "FOS is involved in growth-related transcriptional control, is a key regulator of osteoclast-macrophage lineage determination, and is a major component of the heterodimeric DNA-binding AP-1 transcription factor complex, which includes JUN family members.  Both proteins contain a bZIP region. AP-1 binds to TREs (TPA-responsive elements) in the promoters of target genes.  (from OMIM 164810 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16824] "c-FOS protein is a transcription factor critical in regulating the development of the skeleton.  c-FOS protein is a major component of the DNA-binding AP-1 transcription complex, which also includes members of the JUN family.  Each protein contains a bZIP domain and a leucine zipper domain.  FOS oncoproteins derive from mutated FOS genes.  These proteins have been found in the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses, which induce osteogenic sarcomas in mice.  The FBJ-MSV v-fos gene encodes a 55 kD protein and the FBR-MSV v-fos gene encodes a 75 kD fusion protein.  (from OMIM 164810 and NCI)"                                                                                                                                                                                                                                                                                                                            
[16825] "Retrovirus-associated DNA sequences (fos) originally isolated from the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses. The proto-oncogene c-fos encodes a nuclear protein that dimerizes with Jun via a zipper motif to form the transcription factor AP1 and is involved in growth-related transcriptional control. The insertion of c-fos into FBJ-MSV or FBR-MSV induces osteogenic sarcomas in mice. The human c-fos gene is located at 14q21-31 on the long arm of chromosome 14."                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16826] "suppressor T-lymphocyte marker that functions as a receptor for MHC class I antigen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16827] "A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16828] "The Adverse Event Expedited Reporting System (AdEERS) is a Web application developed for the electronic submission of Expedited Reports to the NCI for serious and/or unexpected Adverse Events, deaths, and other events defined in the NCI Guidlines: Adverse Event Reporting Requirements for NCI Investigational Agents"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16829] "Encoded by Protein Tyrosine Phosphatase Genes, Protein Tyrosine Phosphatases are a group of enzymes that specifically remove tyrosine-bound phosphate groups from many phosphoproteins, including many enzymes phosphorylated by a tyrosine kinase. Together with protein tyrosine kinases, Tyrosine Phosphatases regulate tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16830] "Caregiver; the primary person in charge of care of a patient, usually a family member or a designated health care professional."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16831] "(KATH-i-ter) A flexible tube used to deliver fluids into or withdraw fluids from the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16832] "SPINK1 is secreted from pancreatic acinar cells into pancreatic juice and is thought to prevent trypsin-catalyzed premature activation of pancreatic zymogens.  It is also found in serum and various normal tissues; SPINK1 is produced by gastrointestinal tract mucosa where it may protect mucosal cells from proteolytic breakdown.  (from OMIM 167790 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16833] "The mechanisms, functions, activities, or processes exhibited by microorganisms, especially bacteria, to resist or to become tolerant to antibiotics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16834] "AP1 is not a single protein, but constitutes a group of related dimeric basic region-leucine zipper proteins that belong to the JUN, FOS, MAF, and ATF subfamilies. The various dimers recognize either 12-O-tetradecanoylphorbol-13-acetate (TPA) response elements or cAMP response elements. JUN is the most potent transcriptional activator in its group, and its transcriptional activity is attenuated and sometimes antagonized by JUNB. (OMIM 165160: based on Nature Cell Biol. 4: E131-E136, 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16835] "FOS Family Genes encode nuclear leucine zipper FOS Family Proteins (FOS, FOSB, FOSL1, and FOSL2) that can dimerize with JUN Family proteins and bind DNA as the AP-1 transcription factor complex to regulate transcription in cell proliferation, differentiation, and transformation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16836] "JUN Family Genes encode nuclear leucine zipper JUN Family Proteins (JUN, JUNB, and JUND) that can homodimerize, or heterodimerize with nuclear leucine zipper FOS Family Proteins, to form the specific promoter/enhancer DNA binding AP-1 transcription factor complex that regulates target gene transcription in cell proliferation, differentiation, and transformation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16837] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16838] "Approved methods, procedures, or tests to diagnose the disease, disordered function, or disability."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16839] "Any of several immunoassay methods that use an enzyme covalently linked to an antigen or antibody as a label; the most common types are enzyme-linked immunosorbent assay (ELISA) and enzyme-multiplied immunoassay technique (EMIT)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16840] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16841] "The study of the flow and regulation of genetic information between DNA, RNA, and protein molecules. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16842] "family of small membrane-bound proteins which, in the presence of GTP/GDP, transduce signals from receptor to effector molecules across the membrane; do not use for other guanine nucleotide binding proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16843] "Populations of Spanish, Portuguese, or Latin American descent residing in countries other than the country of their origin. (PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16844] "Histone H2B is a core subunit of the eukaryotic nucleosome complex. Histones are basic nuclear proteins responsible for the nucleosome structure of chromatin. Repeating nucleosome units contain two molecules each of Histones H2A, H2B, H3, and H4 that form an octamer complex around which approximately 146 base pairs of DNA is wrapped. Linker Histone H1 interacts with DNA between nucleosome units in mediating chromatin compaction into higher order structures. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16845] "One of several soluble proteins involved in the initiation of protein or RNA synthesis. (On-line Medical Dictionary"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16846] "A nuclear transcription factor of the bZIP family, JUNB regulates gene activity following primary growth factor response. JUNB binds the 5'-TGA(C/G)TCA-3' DNA sequence as an homo-dimer, or as a hetero-dimer with another member of the JUN/FOS family. JUNB appears to be a key transcriptional regulator of myelopoiesis and a potential tumor suppressor gene. (from SWISS-PROT P17275, OMIM 165161, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16847] "JUND belongs to the bZIP family and probably binds to AP-1 sites as a dimmer to stimulate activity of the associated promoter. Having an apparent anti-apoptotic role, JUND protects cells from senescence, or apoptotic responses to stress stimuli, by acting as a modulator of the RAS signaling pathways to p53. (from SWISS-PROT P17535, OMIM 165162, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16848] "A viral and cellular gene. A proto-oncogene, identified in several avian tumors, encoding a nuclear protein with a leucine zipper motif."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16849] "The exchange of information between people.  Often used as a citation when information is passed from one researcher to another, but is not published."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16850] "A fibrosarcoma, originally observed in a Plymouth Rock hen, now thought to be an expression of infection by certain viruses of the avian leukosis-sarcoma complex in the family"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16851] "The state of being old."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16852] "An overall rank based on characteristics such as education and occupation, used to describe people's positions in stratification systems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16853] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16854] "Telomerase activity was recently shown to be an independent prognostic factor in neuroblastoma.  Telomerase activity and gene expression of telomerase subunits in neuroblastoma tissues are associated with significantly reduced event-free and overall survival. (from J Clin Oncol 2000;18:2582-2592 (via Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16855] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16856] "Active at neutral pH. Several variants of this enzyme exist; the human erythrocyte enzyme is relatively specific for removal of N-acetylalanine from peptides. Displays dipeptidyl-peptidase activity on glycyl-peptides, perhaps as a result of mis-recognition of the glycyl residue as an uncharged N-acyl group. Inhibited by diisopropyl fluorophosphate. In peptidase family S9 (prolyl oligopeptidase family). [EC 3.4.19.1 created 1978 as EC 3.4.14.3, transferred 1981 to EC 3.4.19.1] (from IUBMB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16857] "Proteins transcribed from the E1A region of adenovirus which are involved in positive regulation of transcription of the early genes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16858] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16859] "AXL protein is a transmembrane receptor tyrosine kinase with novel structure, is evolutionarily conserved among vertebrate species, and is widely expressed in monocytes and macrophages but not in B- or T-lymphocytes.  The transforming capacity of AXL results from over expression, rather than from structural mutation.  Although normal AXL function is unknown, the transforming activity of AXL demonstrates that the receptor can drive cell proliferation. Growth arrest-specific gene-6 is an AXL stimulatory factor.  (from OMIM 109135 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16860] "The 94 kD B-RAF serine/threonine protein kinase is a signaling factor critical for formation of the vascular system.  Fusion of TIF1A to B-RAF results in production of a TIF1-alpha-B-RAF oncoprotein.  The BRAF gene encodes the human homologue of the avian c-Rmil proto-oncogene.  (from OMIM 164757 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16861] "The 160 kD BCR phosphoprotein exhibits a unique serine/threonine kinase activity, at least two SH2 binding sites, and a C-terminal GTPase activating domain for p21(rac).  The Philadelphia translocation produces a BCR-ABL1 chimeric product required for induction and maintenance of leukemia.  (from OMIM 151410 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16862] "Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete. (from OMIM)"                                                                                                                         
[16863] "Contiguous with the LH beta subunit gene on chromosome 19q13.3, six homologous genes arranged in tandem and inverted pairs encode the beta subunit of Chorionic Gonadotropin (Glycoprotein Hormone Beta Family).Glycoprotein hormones are heterodimers of a common alpha subunit and a unique beta subunit that confers biological specificity. Produced by placental trophoblasts, Chorionic Gonadotropin stimulates ovarian steroid synthesis essential for maintenance of pregnancy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16864] "Involved in transcriptional repression, BMI1 heritably modifies chromatin, changing its expressibility. BMI1 may repress HOX genes as part of the Polycomb Complex to regulate segmental identity. BMI1 contains a ring-type, putative zinc finger and Polycomb-Group homology domain. BMI1 may complex with RING1. (from SWISS-PROT P35226, OMIM 164831, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16865] "A member of the ETS family of transcription factors, ETS1 Protein is a set of 42-52 kD nuclear phosphoproteins that activate transcription by interaction with purine-rich sequences in gene promoter/enhancer regions.  (from OMIM 164720 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16866] "A member of the ETS family of transcription factors, ETS2 Protein activity is potentiated by signaling through the RAS-RAF-MEK kinase cascade and inhibited by direct interaction with the HLH ID1 protein.  (from OMIM 164740 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16867] "p55-FGR tyrosine kinase contains an SH2 domain, an SH3 domain and belongs to the SRC subfamily.  (from OMIM 164940, Swiss-Prot P09769, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16868] "A serine/threonine kinase involved in cellular signal transduction. Raf is a component of a signal transduction pathway leading to increased gene expression through the c-Jun DNA binding site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16869] "Vitamin D3 Receptors are cytoplasmic polypeptides that specifically bind 1,25(OH)2D3, migrate to the nucleus, and regulate transcription of specific target genes to produce a variety of biologic effects.  The VDR protein belongs to the steroid superfamily of trans-acting transcriptional regulatory factors and is most closely related to the thyroid hormone receptors.  VDR residues immediately N-terminal of the first DNA-binding zinc finger are vital for contact with TFIIB.  (from OMIM 601769 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16870] "A protein which binds to enhancers having a conserved CCAAT sequence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16871] "Fc-Gamma Receptor III is expressed on natural killer cells, granulocytes, and monocytes.  It is included in the zeta natural killer cell receptor complex.  Fc receptor III is encoded by two separate genes: one for the neutrophil receptor (CD16) and another for the receptor on natural killer cells and macrophages.  Some gamma-delta T-cells express CD16.  Mitogenic stimulation of circulating gamma-delta T-cells results in decreased expression of CD16.  (from OMIM 146740 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16872] "CD antigen expressed on surface of monocytes, macrophages, eosinophils, neutrophils; lipopolysaccharide receptor; signals production of tumor necrosis factor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16873] "CTLA-4 is an inhibitory T-cell surface receptor for B7 ligands on antigen presenting cells. It contains an extracellular V-like domain, a transmembrane region, and a putative cytoplasmic domain. It shares significant homology with CD28. Both bind the same ligands, however CTLA-4 binds to B7 with a greater affinity. B7 antigen-presenting cells regulate T-cell activation by delivering antigen-independent stimulatory signals through CD28 and inhibitory signals through CTLA-4. While CD28 is on the membrane of resting T-cells, CTLA-4 is detectable only on cells activated after antigen presentation. A CTLA-4 splice variant with a deleted transmembrane segment is preferentially expressed in non-activated T-cells. Activation of lymphocytes results in the disappearance of sCTLA-4 followed by its gradual reappearance, whereas CTLA-4 increases after activation. CTLA-4 may play an inhibitory role in regulating lymphocyte expansion. (from OMIM 123890 and NCI)"   
[16874] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16875] "Cell adhesion molecule and CD antigen that mediates neutrophil, monocyte, and memory T-cell adhesion to cytokine-activated endothelial cells. E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16876] "The gene encoding this protein is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. This protein is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. (from LocusLink)"                                                                                                                                                                                                                                   
[16877] "A zinc-finger transcription factor that binds to GATA elements in regulatory regions of globin and other erythroid-specific genes.  Also known as GF-1, NF-E1 and Eryf 1.  Its expression is restricted to a subset of hematopoietic cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16878] "GEFs.  Proteins that catalyze the release and exchange of GDP for GTP from GTP-binding regulatory proteins, which are active in the GTP-bound form.  The prototypical GEF is the eukaryotic initiation factor 2b, eIF-2B.  Among other GTP-binding proteins regulated in this manner is p21 ras."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16879] "The HEK receptor tyrosine kinase shows a high degree of homology with EPH and ELK RTKs.  The largest subfamily of RTKs, EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. EPH-family receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EPH receptors are divided into two groups based on their extracellular domain sequences and affinities for ephrin-A (EPHA) and ephrin-B ligands (EPHB). HEK expression appears restricted to lymphoid tumor cell lines, suggesting that HEK may contribute to lymphoid malignancies and normal lymphoid function and differentiation. (from OMIM 179611 and NCI)"                                                                                                                                                                                                                                 
[16880] "the products of \"hybrid histocompatibility\" (Hh) loci, responsible for the phenomenon known as hybrid resistance. (from Fundamental Immunology, 3rd ed., William Paul, ed., Raven Press, NY 1993, pg 1104-1105)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16881] "a DNA-binding nuclear transcription factor.  HOX11 is an orphan homeobox gene since it is located at a site outside the 4 mammalian HOX clusters. Whereas the orthodox HOX genes encode a combinatorial system of positional specification along the anterior-posterior axis of the embryo, the function of orphan homeobox genes is less well understood.  Essential for the survival of splenic precursors during organogenesis. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16882] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16884] "The E5 protein of the Human Papillomavirus encodes a short hydrophobic peptide, which appears to alter the turnover rate of the EGF receptor in keratinocytes, thereby enhancing their growth. (Virology 280:169-75, 2001)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16885] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16886] "CD102.  Intracellular Adhesion Molecule-2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16887] "ICAM3 is a ligand for LFA-1, a major receptor of T-cells, B-cells, and granulocytes that mediates the leukocyte adhesion reactions underlying many immune functions.  The interaction of LFA-1 with ICAM provides essential accessory adhesion signals in many immune interactions, including those between T- and B-lymphocytes and cytotoxic T-cells and their targets.  ICAM3 is potentially the most important ligand for LFA-1 in the initiation of the immune response.  ICAM3 is closely related to ICAM1, consists of five Ig domains, and binds LFA-1 through its two N-terminal domains.  (from OMIM 146631 and NCI)"                                                                                                                                                                                                                                                                                                                                                                     
[16888] "Encoded by human IGFBP1 Gene and expressed in liver, endometrium, and decidua, low molecular weight secreted 259-aa 29-kD Insulin-Like Growth Factor-Binding Protein 1 precursor contains an IGFBP domain and a thyroglobulin type-I domain. IGFBP1 binds equally to plasma IGF I and IGF II with high affinity. The protein has 15 N- and C-terminal cysteines and a C-terminal RGD sequence that may promote potentiation of IGF I biologic actions. IGFBP1 is probably phosphorylated by casein kinase II, which alters IGF affinity. IGF-binding proteins prolong the half-life of IGFs and alter IGF interactions with cell surface receptors. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                    
[16889] "Encoded by human IGFBP2 Gene, cysteine-rich high molecular weight secreted 328-aa 35-kD Insulin-Like Growth Factor-Binding Protein 2 precursor contains an IGFBP domain and a thyroglobulin type-I domain. IGF-binding proteins prolong plasma IGF half-life and alter IGF interaction with cell surface receptors. The predominant form in plasma (150-kD) contains IGF-BP53 with apparent molecular mass of 53-kD. IGFBP2 binds IGF-II with high affinity more than IGF-I. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16890] "IGFBP4 belongs to the IGFBP family. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. Secreted IGFBPs prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs. They alter the interaction of IGFs with cell surface receptors. IGFBP4 contains a thyroglobulin type-I domain and binds IGF-II more than IGF-I. IGFBP4 inhibits IGF-induced bone cell proliferation. (from OMIM 146733, SWISS-PROT P22692, and NCI)"                                                                                                                                                                                                                                                                                                       
[16891] "IGFBP5 contains a thyroglobulin type-I domain and belongs to the IGFBP family.  IGFBPs display strong sequence homologies.  IGFBPs contain three distinct domains. N-terminal domain 1 and C-terminal domain 3 contain invariant cysteine residues and are thought to be the IGF binding domains.  Domain 2 generally lacks sequence identity among the IGFBPs.  Domain 3 is homologous to the thyroglobulin type I repeat.  IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs.  IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis; the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism.  Secreted IGF-binding proteins prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs; they alter the interaction of IGFs with cell surface receptors.  (from OMIM 146734, SWISS-PROT P22692, and NCI)"                                     
[16892] "IGFBP3 belongs to the IGFBP family. IGFBP3 functions as the major carrying protein for IGF1 and IGF2 in the circulation, modulates IGF activity, and inhibits cell growth. IGFBP3 binds IGF-II more than IGF-I. Endothelial IGFBP3 forms a ternary complex with IGF-I or IGF-II and an 85 kD glycoprotein (ALS). IGFBP3 levels increase in the presence of IGF-I, insulin and other growth-stimulating factors such as growth hormone, epidermal growth factor, and phorbol esters. IGFBP3 may control angiogenesis and cell responses in the corpus luteum by autocrine/paracrine mechanisms. IGFBP3 also possesses growth-inhibitory and -potentiating effects that are independent of IGF and are mediated through specific receptors. As a specific IGFBP3-binding protein, transferrin blocks IGFBP3-induced cell proliferation and IGFBP3-induced apoptosis. (from OMIM 146732, SWISS-PROT P17936, and NCI)"                                                                                  
[16893] "The WNT2 protein is a secreted growth factor member of the INT1 gene family and is associated with breast cancer.  WNT2 is expressed in a variety of fetal and adult human tissues.  (from OMIM 147870 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16894] "L-Plastin is an actin-binding lymphocyte cytosolic protein identical to p65, an IL2-stimulated phosphoprotein in T-cells.  It contains two EF-hand calcium-binding domains, a calmodulin-binding site, and two tandem actin-binding domains.  (from OMIM 153430 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16895] "L-Selectin is a cell surface glycoprotein adhesion molecule that serves as a homing receptor for lymphocytes to lymph node high endothelial venules.  The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to C3/C4 binding protein consensus repeat units.  L-Selectin may also play a role in neutrophil adhesion to endothelium at sites of inflammation.  A tissue-specific mucin-like endothelial glycoprotein appears to function as ligand for L-selectin, in the role of scaffold that presents carbohydrates to the L-selectin lectin domain.  PLAUR is directly associated with the carbohydrate-binding domain of L-selectin in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins.  (from OMIM 153240 and NCI)"                                                                                                                                                               
[16896] "Expressed only in normal testis and placenta by human MAGEA3 Gene, MAGE-3.1 Antigen has an unknown function. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16897] "MCC is a candidate for the putative colorectal tumor suppressor gene. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16898] "Inhibits p53 trans-activation, cell cycle arrest, and apoptosis. MDM2 binds p53 in the cell cycle at S/G2M phase and targets p53 for proteasome-mediated proteolysis. MDM2 also inhibits Rb protein and binds p14(ARF), ribosomal protein L5, and specifically to RNA. MDM2 gene expression is induced by DNA damage and regulated by the Ras-MAP kinase pathway. Some soft tissue sarcomas carry amplified MDM2 and overexpress MDM2 protein. (from SWISS-PROT Q00987, OMIM 164785, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16899] "Human APEH Gene (S9 Peptidase Family) encodes Acylaminoacyl-Peptidase, active at neutral pH. Several variants of this enzyme exist; the human erythrocyte enzyme is relatively specific for removal of N-acetylalanine from peptides. APEH displays dipeptidyl-peptidase activity on glycyl-peptides, perhaps as a result of mis-recognition of the glycyl residue as an uncharged N-acyl group. APEH is inhibited by diisopropyl fluorophosphate. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16900] "Proteins that give shape to the nucleus and provide support for the chromosomes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16901] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16902] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16903] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16904] "Encoded by human POU2F1 Gene (POU2 Family), ubiquitous transcription factor OTF-1 contains one homeobox domain, binds to the octamer ATTTGCAT motif, and activates genes for some snRNA, histone H2B, and immunoglobulins. POU domain proteins contain a bipartite DNA-binding domain divided by a flexible linker that enables diverse monomeric configurations on DNA; additional versatility is conferred by dimerization. OTF-1 POU dimers on palindromic OCT factor recognition elements, or PORE, (ATTTGAAATGCAAAT) can recruit transcriptional coactivator OBF1. OTF-1 iinteracts with transcription activators NR3C1, AR, and PGR. (from LocusLink, Swiss-Prot, and NCI)"                                                                                                                                                                                                                                                                                                                   
[16905] "P-Selectin is a cell surface adhesion molecule that mediates the interaction of activated endothelial cells or platelets with neutrophils and monocytes.  The protein is detected in megakaryocytes and platelets, as well as in vascular endothelial cells, but not in other cell types.  In endothelia, the protein is localized to the membranes of Weibel-Palade bodies, intracellular storage granules for von Willebrand factor.  CD24 is a ligand for P-selectin.  Sorting nexin-17 interacts with the cytosolic domain of P-selectin and may function in the intracellular trafficking of P-selectin.  (from OMIM 173610 and NCI)"                                                                                                                                                                                                                                                                                                                                                          
[16906] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16907] "Plakoglobin (gamma-Catenin) is a major soluble and membrane-associated cytoplasmic protein common to desmosomes and intermediate junctions.  It associates with the cytoplasmic region of Desmoglein I and mediates the connection of cadherins to actin filaments and to other transmembrane and peripheral cytoplasmic proteins in epithelial adherens junctions.  The cadherin-catenin complex interacts with EGFR; beta-Catenin and Plakoglobin are tyrosine phosphorylated by activated EGFR.  APC binds to and regulates beta- and gamma-Catenin.  Homologues of Drosophila armadillo, beta-Catenin and gamma-Catenin have analogous structures and functions in cell adhesion and the WNT signaling pathway.  Several mutations of gamma-Catenin have transforming activity dependent on TCF/LEF and c-MYC function.  Beta- and gamma-Catenin may have distinct roles in WNT signaling via differential effects on downstream target genes.  (from OMIM 173325 and NCI)"                     
[16908] "Alternate isoforms of the single-chain 261-aa 30-kD Kallikrein 3 (Prostate Specific Antigen) glycoprotein precursor are encoded by human KLK3 Gene (Kallikrein Family). Frameshifted isoform 2 has a shorter distinct C-terminus. A serine protease in seminal plasma, PSA may function in liquefaction of seminal coagulum by (preferential Tyr-X) cleavage of seminal vesicle protein. Kallikrein proteases have diverse functions. Mounting evidence implicates kallikreins in carcinogenesis; some have potential as cancer biomarkers. The serum level of PSA is useful in diagnosis and monitoring of prostatic carcinoma. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                       
[16909] "A heterodimeric enzyme (alpha and beta subunits) that catalyzes the addition of farnesyl groups, as farnesyl diphosphate, to the C termini of proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16910] "A papillomavirus capsid protein"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16911] "CSK is a novel cytoplasmic tyrosine kinase that down regulates the tyrosine kinase activity of c-src oncoprotein through phosphorylation of the c-src carboxy terminus.  Since cell transformation by SRC oncoproteins is caused by mechanisms that interfere with this phosphorylation, CSK might function as an antioncogene.  The CSK gene is ubiquitously expressed.  The SH3 domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells.  This association is highly specific; PEP may be an effector and/or regulator of CSK in T-cells and other hemopoietic cells.  (from OMIM 124095 and NCI)"                                                                                                                                                                                                                                                                                                                              
[16912] "A sub-type of MHC Class I"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16913] "The protein on surface of target cells specific for binding IGF.  There are two types of IGF receptor, one of which closely resembles the insulin receptor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16914] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16915] "Retinoid receptors (RARA, RARB, RARG) require co-regulators to increase selective binding to DNA response elements in target genes and enhance transcriptional activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16916] "A protein that binds retinoic acid with high affinity, RAR alpha is homologous to the steroid receptor superfamily and a retinoic acid-inducible transacting enhancer factor. There are at least two retinoic acid receptors, RAR alpha and RAR beta. Binding of ligand to receptors attracts co-activator proteins containing a NR box. NCOR1 and SMRT contain CoRNR box sequences, similar to the NR box, in receptor interaction domains and mediate inhibition of gene transcription by RARs. Sequences flanking the CoRNR box determine receptor specificity.  Differential recognition of receptors by co-activators and co-repressors is due to subtle differences between CoRNR and NR boxes. The association of SMRT with receptors is destabilized by ligand, triggering the activation process. The repressor function of SMRT may promote interaction with transcription factor TFIIB. (from OMIM 180240 and NCI)"                                                                      
[16917] "Human nuclear Retinoid X Receptors RXRA, RXRB, and RXRG (NR2/RXR Family) are transcriptional regulators composed of N-terminal modulating domain, DNA-binding domain (AGGTCA response elements), and C-terminal 9-cis RA-binding domain. RXR homodimers and RXR/RAR heterodimers mediate distinct retinoic acid response pathways.  RXRs also interact with TH- and vitamin D receptors, and with NCOA3, NCOA6, PML, and PPARG coactivators; and mediate RA biological effects by binding to specific target gene promoters and inducing target gene transcription. RXRs/LXRs and RXRs/FXR may mediate cholesterol homeostasis, by governing cholesterol transport from peripheral cells, inhibiting cholesterol absorption in the small intestine, and repressing bile acid synthesis through upregulation of ABC1 and repression of CYP7A1 expression. (NCI)"                                                                                                                                     
[16918] "Class of divalent cation-dependent receptors that recognizes sequence Arg-Gly-Asp in adhesive protein; examples are fibronectin & vitronectin receptors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16919] "An integral membrane transport protein.  Expression of the sodium/iodide symporter (NIS) is high in lactating mammary tissue and in over 80% of breast cancers, but is not found in normal breast tissue. This suggests that radioactive iodine could be useful in diagnosing or treating breast cancers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16920] "Believed to be part of a transcriptional-repression protein complex involved in modulating chromatin structure. The SPT5 amino terminus is highly acidic, while the C-terminus contains seven Mitogen-Activated Protein (MAP) Kinase consensus sequences. (OMIM 602102 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16921] "A DNA repair enzyme from bacteriophage T4.  It catalyzes the first reaction step of the excision repair pathway to remove pyrimidine-dimers produced within duplex DNA by UV irradiation.  It has been incorporated into a topical lotion for treatment of xeroderma pigentosum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16922] "Encoded by human POU2F2 Gene (POU2 Family), alternative isoforms 1 (478-aa, 51-kD), 2 (466-aa), 3 (462-aa), and 4 (399-aa) of transcription factor OTF-2 contain a DNA binding homeobox domain, bind to octamer motif ATTTGCAT, and regulate Ig gene expression and transcription in several other tissues. OTF-2 also interacts with transcription activators NR3C1, AR, and PGR. Neuronal NOS gene is a target of OTF-2. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16923] "TFIID is a DNA-binding protein complex required for RNA polymerase II-mediated transcription of many, if not all, protein-encoding genes in eukaryotic cells. TFIID plays a key role in initiation, since it binds to the TATA element to form a complex that nucleates the assembly of the other components into a preinitiation complex. TFIID interacts with TFIIA, which may stabilize its binding. A reinitiation intermediate including TFIID can act as a scaffold for formation of a functional reinitiation complex. TFIID also links the control of transcription to the cell cycle. The DNA-binding subunit of TFIID is the TATA box-binding protein (TBP) that interacts primarily within the minor groove of the DNA helix. The largest subunit of TFIID is TAF1, which can autophosphorylate and transphosphorylate the large subunit of the basal factor TFIIF. (From OMIM and NCI)"                                                                                                 
[16924] "The RNA polymerase III initiation factor TFIIIB is assembled onto DNA through interactions involving the Tfc4 subunit of the assembly factor TFIIIC and two subunits of TFIIIB, Brf1 and Bdp1."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16925] "Encoded by constitutive human TIMP2 Gene (TIMP Family), 207-aa 28-kD secreted TIMP-2 protein contains 12 cysteines and 3 conserved tryptophans. Activity dependent on disulfide bonds, TIMP-2 complexes with and inactivates matrix metalloproteinases involved in extracellular matrix degradation and connective tissue remodeling. TIMP family members may possess selective affinities for matrix metalloproteinases and TIMP-2 may play a different role from TIMP-1 or TIMP-3. TIMP-2 inhibits type IV collagenase in a stoichiometric fashion and acts on MMP-1, -2, -3, -7, -8, -9, -10, -13, -14, -15, -16 and -19. The N-terminus is responsible for MMP inhibition; the C-terminus mediates specific molecular functions. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                   
[16926] "Encoded by human TIMP1 Gene (TIMP Family) TIMP-1 expression in platelets and macrophages is highly inducible by cytokines and hormones. A 207-aa 28-kD secreted glycoprotein growth factor that mediates erythropoiesis, TIMP-1 tightly complexes with and inhibits collagenase as well as connective tissue metalloendoproteases, involved in extracellular matrix degradation and connective tissue remodeling. Activity dependent on disulfide bonds, TIMP1 acts on MMP-1, -2, -3, -7, -8, -9, -10, -11, -12, -13 and -16. TIMP family members may possess selective affinities for matrix metalloproteinases. The N-terminus is responsible for MMP inhibition; the C-terminus mediates specific molecular functions. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                              
[16927] "21-27 kDa proteins found in the extracellular matrix; regulate the activity of collagenase and therefore are important in tumorigenesis, angiogenesis, chondrosteosis, and other tissue forming processes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16928] "Activator Protein 2.  Originally identified as a cellular transcription factor that binds the enhancer region of SV40.  It is encoded by a family of related genes, AP-2 alpha, AP-2 beta, and AP-2 gamma.  AP-2 is developmentally regulated and inducible by RET."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16929] "Transcription factor E2F1 binds to DNA as homo or heterodimers with DP1 or DP2. It activates p53 and p73 gene expression. MYC-induced apoptosis involves E2F1. E2F1 can induce apoptosis in a p53-independent manner by accumulation of p73 or by a death receptor-dependent mechanism via down regulating TRAF2 and inhibiting activation of NFKB anti-apoptotic signals. E2F1 induces p53-dependent apoptosis by inducing ARF, which neutralizes MDM2 and stabilizes p53. E2F is a critical determinant of G1/S transition, activating transcription of genes necessary for DNA replication. RB interacts with E2F factors to arrest cells in G1 by active transcriptional repression. RB/E2F repression mediates G1 arrest triggered by TGFB, by p16(INK4A), and by contact inhibition. Accumulation of G1 cyclins E and D1 is regulated by E2F1. TCR-AICD, in a p53-independent late G1 phase cell-cycle checkpoint, is dependent on E2F1 and TP73. (from OMIM and NCI)"                        
[16930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16931] "An elastase homolog involved in immune reactions of neutrophils and monocytes.  Stored in a specialized lysosome, the azurophil granule, it degrades elastin and other connective tissue proteins and contributes to antimicrobial defenses.  Identical to myeloblastin, it is a target of autoantibodies associated with Wegener's granulomatosis, and is known as Wegener's autoantigen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16932] "A potential regulator of transcription, WT1 belongs to the EGR family of C2H2 zinc-finger proteins and binds to the DNA sequence 5'-CGCCCCCGC-3'. Inactivation of WT1 is one cause of Wilm's Tumor, an embryonal malignancy of the kidney. Defects in WT1 are also associated with Denys-Drash Syndrome (DDS) and Diffuse Mesangial Sclerosis (DMS). (from SWISS-PROT P19544, OMIM 194070, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16933] "Hepatitis B virus X protein; a hepatitis B viral product relevant to hepatocarcinogenesis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16934] "The process of defending or pleading the cause of another individual or group (from PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16935] "Descriptive study of cultures and societies. Used for the scientific discipline or the descriptive analyses themselves. Consider also ETHNOLOGY. (PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16936] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16937] "The process by which an unexpressed gene is activated to serve as a transcription template for synthesis of RNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16938] "An oncogene from an avian sarcoma virus. The protein it encodes dimerizes with fos to form the transcription factor AP1."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16939] "location or environment where an individual is employed; e.g. office, laboratory, building, warehouse, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16940] "(ap-o-TOE-sis) A normal series of events in a cell that leads to its death."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16941] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16942] "A type of enzyme that breaks down the protein collagen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16943] "The covalent addition of prenyl and multiprenyl residues to a macromolecule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[16944] "A protein created by joining two genes together. Fusion proteins may occur naturally or can be created in the laboratory for research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16945] "Use of a DNA or RNA probe to detect the presence of complementary sequences in chromosomes, cells, or tissues"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16946] "A physical mapping approach that uses fluorescent tags to detect hybridization of probes within metaphase chromosomes or less condensed somatic interphase chromatin. This technique can be used for identification of chromosomal abnormalities and for gene mapping. (from Online Medical Dictionary and NHGRI Glossary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16948] "1) Determination of the sequence of component residues in a macromolecule, e.g. amino acids in a protein or nucleotide bases in DNA/RNA.  2) Computational analysis performed to determine the similarities between nonidentical proteins or molecules of DNA or RNA.  In the case of proteins this helps identify regions involved in specific common functions (e.g. catalysis, ligand binding) or processed in a similar fashion (e.g. glycosylation, nuclear transport).  In the case of DNA/RNA, sequence analysis aids in the identification of cis-acting elements active in the regulation of gene expression or other genetic activities, or processing of RNA transcription products."                                                                                                                                                                                                                                                                                                    
[16949] "Expressed in a variety of tissues, human MCC Gene at 5q21 encodes MCC Protein, a putative tumor suppressor protein with a short region of similarity to a G protein-coupled M3 muscarinic acetylcholine receptor. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16950] "The APC gene at 5q21-q22 consists of fifteen exons and is expressed in a variety of tissues from two promoters. Tissue-specific splicing generates transcripts with at least five 5-prime noncoding forms and a brain-specific transcript contains an extra exon. APC protein forms homooligomers and is located in the membrane/cytoskeleton or in the nucleus. APC/ASEF complexes regulates the actin cytoskeleton. Cytoplasmic APC is often found in mesenchymal and epithelial subapical regions and may regulate cell adhesion or contact inhibition by maintaining beta-catenin steady state levels. APC/beta-catenin binds to DLG, which may regulate cell cycle progression and neuronal function. Accumulation of beta-catenin increases transcription of TCF4 target genes, such as MYC. Mutation of APC is associated with familial adenomatous polyposis, Gardner's syndrome, HDD/FIF, Turcot syndrome, and sporadic colorectal cancer. (from SWISS-PROT, OMIM, and NCI)"               
[16951] "process by which polypeptide chains assume their three-dimensional conformation, either during normal protein biosynthesis or experimental protein reconstitution."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16952] "Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids.  Inhibited by chelating agents; requires divalent cations for activity.  Previously regarded as identical with EC 3.1.1.2 Arylesterase [EC 3.1.8.1 created 1989] (from IUBMB Enzyme Nomenclature)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[16953] "A human nuclear matrix protein with demonstrated immunohistochemical staining differences between benign and malignant prostate tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16954] "This protein is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16955] "Focal adhesion kinase (PTK2) lacks significant homology with other kinases and concentrates in focal adhesions between cells growing in extracellular matrix constituents. PTK2 contains phosphotyrosine in growing cells, or after treatment with cholecystokinin, bombesin, vasopressin, or endothelin, but little in detached cells. Activation of PTK2 may be important in signal transduction pathways triggered by neural peptides or by cell interactions with the extracellular matrix. PTK2 is a major substrate for pp60v-src. A CRK-associated tyrosine kinase substrate, p130-CAS, is a PTK2-interacting protein. This interaction requires the proline-rich region of PTK2 and the SH3 domain of p130-CAS. The interaction may also be a key element in integrin-mediated signal transduction and may represent a direct molecular link between the SRC and CRK oncoproteins. FAK may be an endogenous substrate for insulin receptor associated tyrosine kinase. (from OMIM and NCI)" 
[16956] "Induced primarily in liver by glucocorticoids, drugs, pesticides, and carcinogens and encoded by human CYP3A4 Gene (Cytochrome P450 IIIA Subfamily), Cytochrome P450 3A4 is a 502-amino acid 57.3-kD membrane-bound ER heme-thiolate monooxygenase. CYP3A4 is involved in an NADPH-dependent electron transport pathway and phase I oxidative metabolism of carcinogens, steroids, fatty acids, and xenobiotics, as well as bioactivation of aflatoxin B(1) to a genotoxic derivative. Activity seems a key predictor of drug responsiveness and toxicity. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                             
[16957] "p59-FYN contains an SH2 and an SH3 domain, is a SRC/YES-related tyrosine kinase expressed in various cell types, and is implicated in the control of cell growth.  FYN is quickly activated after mIg cross-linking on B-cells or TCR cross-linking on T-cells.  FYN associates, through its SH3 domain, with PI3-kinase p85 subunit and interacts with FYN-binding protein FYB.  Upon induction of the murine 1C11 clone by PrPc-dependent signal transduction, epithelial cells develop a neural-like morphology and differentiate into either serotonergic or noradrenergic cells, depending on stimulus.  Phosphorylation of FYN is linked to ligation of PrPc, the cellular, nonpathogenic isoform of prion protein, a ubiquitous glycoprotein expressed strongly in neurons.  The coupling of PrPc to FYN is dependent upon caveolin-1. (from OMIM 137025, Swiss-Prot P06241, and NCI)"                                                                                                       
[16958] "Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This enzyme degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. (from LocusLink)"                                                                                                                                                                                                                                                                                                        
[16959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16960] "Secreted by tumor cells, autocrine motility factor stimulates tumor motility.  Its glycoprotein receptor, Autocrine Mobility Factor Receptor, has some homology to p53.  In normal fibroblasts, receptor expression appears to be regulated by cell-cell contact.  The level of expression is associated with the pathologic stage and grade of tumor penetration.  Positive AMFR expression on tumor cells correlates with poor prognosis in bladder cancer.  (from OMIM 603243 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16961] "The TATA Binding Protein (TBP) is a DNA-binding component of the TFIID basal transcription factor of the class II genes (transcribed by RNA polymerase II), the TFIIIB class III transcription factor, and the TIF-1B (SL1) class I factor.  Its name is derived from the A-T rich DNA motif that it binds to in the class II genes, most commonly TATAAAA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[16962] "RAC-Alpha Serine/Threonine Kinase (AKT1) encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. The activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. AKT1 also promotes cell survival and regulates nitric oxide from endothelium, target of the PDGF-activated phosphatidylinositol 3-kinase. (From LocusLink and NCI)"                                                                                             
[16963] "The AKT2 oncogene encodes RAC-beta protein kinase, belonging to a serine/threonine kinase subfamily containing SH2-like domains.  The AKT2 isoform of PI-dependent protein kinase Akt is enriched in insulin-responsive tissues and may function in the metabolic actions of that hormone.  Glucose homeostasis depends on insulin responsiveness in target tissues.  Insulin induces phosphorylation of scaffolding proteins and activation of PI3-kinase, which activate Akt.  A deficiency of Akt2 impaires the ability of insulin to lower blood glucose and may function in the maintenance of normal glucose homeostasis.  (from OMIM 164731 and NCI)"                                                                                                                                                                                                                                                                                                                                        
[16964] "The protein is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16965] "Bipartite DNA binding protein containing a basic region that directly interacts with DNA, and a leucine zipper that mediates dimerization through contacts with a protein partner."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[16966] "Interacting with p65 (RELA), widely expressed 36-38kDa unphosphorylated cytoplasmic ANK-repeat human I Kappa B Proteins A/B/E (NFKBI Family) inhibit NF-Kappa-B, trapping it in the cytoplasm. By complexing with NFKB, IKBs regulate NFKB transcription in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. Cytokine-activated serine phosphorylation of IKBs by IKBKA/IKBKB disables the NFKB inhibition by dissociation; promotes polyubiquitinated proteasome-dependent IKB degradation; and allows NFKB nuclear translocation, binding at kappa-B DNA motifs, and target gene transcription. (NCI)"                                                                                                                                                                                                                                                                                                                                                
[16967] "Forkhead Box Protein G1B acts as transcriptional repressor and belongs to the large FKH/HNF3 family of transcription factors, that includes the Drosophila homeotic FKH and mammalian HNF3 and BF1 proteins.  Family members share a unique DNA-binding FKH box.  FOXG1B expression is restricted to telencephalic neurons, with strong expression in the dentate gyrus and hippocampus.  (from OMIM 164874 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16968] "GLUT1 is an integral membrane glycoprotein involved in transporting glucose into most cells.  It is consistently overexpressed in endometrial adenocarcinomas and atypical hyperplasia, but not in typical hyperplasia.  Immunostaining for GLUT1 may distinguish benign endometrial hyperplasia from potentially malignant hyperplasia.  GLUT1 immunoreactivity in endometrial hyperplasia appears to be a useful indicator of high risk for development of endometrial carcinoma. (from Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16969] "A negative regulator of cell proliferation, KIP2 is a tight-binding inhibitor of the G1 Cyclin E-CDK2, Cyclin D2-CDK4, and Cyclin A-CDK2 complexes, and also inhibits mitotic Cyclin B-CDC2. The N-terminal CDK inhibitory domain is similar to p21(CIP1). (from SWISS-PROT P49918, OMIM 600856, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16970] "IGFBP6 contains a thyroglobulin type-I domain, belongs to the IGFBP family, and may function as an autocrine growth inhibitor. IGFBPs display strong sequence homologies. IGFBPs contain three distinct domains. N-terminal domain 1 and C-terminal domain 3 contain invariant cysteine residues and are the IGF binding domains. Domain 2 generally lacks sequence identity among the IGFBPs. Domain 3 is homologous to the thyroglobulin type I repeat.  IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. Secreted IGF-binding proteins prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs by altering the interaction of IGFs with cell surface receptors. (from OMIM 146735, SWISS-PROT P24592 and NCI)"        
[16971] "A subunit of the P/CAF transcription complex, SPT3 is similar to yeast SPT3. (from OMIM 602947 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16972] "Encoded by Human MAPK1 Gene (MAPK Family) as alternative p40 and p41 isoforms, Mitogen-Activated Protein Kinase 1 is a proline-directed Ser/Thr kinase activated in response to extracellular stimuli and widely involved in signal transduction as an integration point for multiple biochemical signals and as part of complex protein kinase cascades involved in a cell proliferation, differentiation, transcription regulation, and development. Autophosphorylated and phosphorylated/activated by upstream kinases on threonine and tyrosine residues, MAPK1 forms dimers with phosphorylated and unphosphorylated ERK partners, translocates to the nucleus and phosphorylates target transcription factors. MAPK1 phosphorylates MAP2, MBP, and ELK-1. (NCI)"                                                                                                                                                                                                                             
[16973] "Acidic fibroblast growth factor stimulates tyrosine kinase activity of FGFR1, the receptor for acidic FGF.  The receptor is a transmembrane protein that contains three extracellular Ig-like domains, an unusual acidic region, and an intracellular tyrosine kinase domain.  (from OMIM 136350 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16974] "An adaptor protein which bridges cell surface tyrosine kinase receptors with downstream signal transmitters such as ras p21. (from IRB Summaries)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16975] "Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This enzyme degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                         
[16976] "Identified in yeast, Zuotin, containing one J domain, is a Z-DNA-binding protein and ribosomal chaperone that may be involved in chromosome organization.  (from OMIM 605502, SWISS-PROT P32527, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16977] "A protease believed to play a role in tumor invasion and metastasis.  May contribute to tissue-remodeling processes associated with carcinoma progression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16978] "The MLL (HRX) nuclear protein contains N-terminal 'AT-hook' motifs and extensive homology to the Drosophila trithorax protein, particularly in the cysteine-rich zinc finger-like domains.  HRX may bind AT-rich DNA and is likely to be a transcriptional regulator.  (from OMIM 159555 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[16979] "A protein tyrosine kinase in the syk family of kinases, with signaling functions in the T-cell receptor (TCR) signal transduction pathway.  Associates with the zeta and CD3 chains of the receptor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16980] "The property of remaining in close proximity, as that resulting from the physical attraction of molecules to a substance or the molecular attraction existing between the surfaces of contacting bodies. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16981] "(pros-THEE-sis) An artificial replacement of a part of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16982] "A specialist in the science of immunology."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16983] "A human who has reached reproductive age"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16984] "Subdiscipline of genetics with a focus on bacteria."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16985] "Critical care nursing is that specialty within nursing that deals specifically with human responses to life-threatening problems. A critical care nurse is a licensed professional nurse who is responsible for ensuring that all critically ill patients and their families receive optimal care. (AACN)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[16986] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16987] "The process of taking raw food and producing a finished meal.  Investigations into the link between food preparation methods and human disease"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16988] "The application of knowledge to the food industry. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[16989] "A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.  The processing may include contrast enhancement, image sharpening, false coloring, the decomposition and extraction of elements to permit a description based on edges, regions and movement, and three-dimensional reconstructions. (From MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[16990] "The gene product limited to virus, and was found in either the nucleocapsid structure or the viral core."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[16991] "this term is to be used for the macro-algae, Embryophytes (mosses), and Tracheophytes (angiosperms, gymnosperms, etc.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[16992] "The molecular steps that continually advance a cancer or cancer cell into a more malignant and aggressive phenotype. The process of tumor progression is thought to be driven by clonal evolution. The initiating event is a mutation that gives a cell the ability to divide when it shouldn't.  As a result a small group of related cells, called a clone because they are identical to each other, grows. Clonal evolution occurs like a tree with mutations causing many clones to branch off continuously."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16993] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[16994] "(BRON-ko-skope) A thin, lighted tube used to examine the inside of the trachea and bronchi, the air passages that lead to the lungs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[16995] "A tube surgically placed into a blood vessel for the purpose of giving intravenous fluid and drugs. It also can be used to obtain blood samples. This device avoids the need for separate needle insertions for each infusion or blood test. Examples of these devices include Hickman catheters, which require clamps to make sure the valve is closed, and Groshong catheters, which have a valve that opens as fluid is withdrawn or infused and remains closed when not in use."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[16996] "(ko-LAHN-o-skope) A thin, lighted tube used to examine the inside of the colon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[16997] "A lighted magnifying instrument used for examination of the vagina and cervix."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[16998] "(kyoo-RET) A spoon-shaped instrument with a sharp edge."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[16999] "(SIS-toe-skope) A thin, lighted instrument used to look inside the bladder and remove tissue samples or small tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17000] "(DYE-lay-tor) A device used to stretch or enlarge an opening."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17001] "(la-RING-guh-skope) A thin, lighted tube used to examine the larynx (voice box)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17002] "(FLOOR-o-skope) An x-ray machine that makes it possible to see internal organs in motion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17003] "(GAS-tro-skope) A thin, lighted tube used to view the inside of the stomach."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17004] "(hyoo-MID-ih-fye-er) A machine that puts moisture in the air."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17005] "(off-THAL-mo-skope) A lighted instrument used to examine the inside of the eye, including the retina and the optic nerve."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17007] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17008] "A device that is used to deliver a precise amount of drug at a specific rate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17009] "(sig-MOY-da-skope) A thin, lighted tube used to view the inside of the colon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17010] "A tuft of material on the end of a stick for applying solutions and suspensions"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17011] "(TRAY-kee-AHS-toe-mee) A 0.5-inch- to 1.5-inch-long plastic tube placed in a surgically created opening (tracheostomy) in the windpipe to keep it open."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17012] "(TRAY-kee-AHS-tuh-mee toob) A 2-inch- to 3-inch-long curved metal or plastic tube placed in a surgically created opening (tracheostomy) in the windpipe to keep it open. Also called a trach (\"trake\") tube."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17013] "A tube surgically placed into a blood vessel and attached to a disk placed under the skin. It is used for the administration of intravenous fluids and drugs; it can also be used to obtain blood samples."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17014] "DRE. An examination in which a doctor inserts a lubricated, gloved finger into the rectum to feel for abnormalities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17015] "Any DNA based laboratory tests."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17016] "Use of restriction fragment polymorphism for detection of point mutations or other chromosomal changes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17017] "Serum measurement of prostate specific antigen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17018] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17019] "An in vitro test of T-cell function"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17020] "An electrophoresis technique which occurs within a capillary tube.  Due to the large surface to volume ratio, cooling is more efficient, allowing use of higher voltages.  As a result, separation occurs more quickly and sensitivity is increased."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17021] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17022] "A series of x-rays of the upper digestive (gastrointestinal, or GI) system that are taken after a person drinks a barium solution, which outlines the digestive organs on the x-rays."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17023] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17024] "(per-kyoo-TAY-nee-us trans-heh-PAT-ik ko-LAN-jee-AH-gra-fee) PTC.  A procedure to x-ray the hepatic and common bile ducts. A contrasting agent is injected into the liver or bile duct, and the ducts are then x-rayed to find the point of obstruction."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17025] "(nef-ro-TOE-mo-gram) A series of x-rays of the kidneys. The x-rays are taken from different angles and show the kidneys clearly, without the shadows of the organs around them."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17026] "(in-tra-VEE-nus PYE-el-o-gram) IVP. A series of x-rays of the kidneys, ureters, and bladder. The x-rays are taken after a dye is injected into a blood vessel. The dye is concentrated in the urine, which outlines the kidneys, ureters, and bladder on the x-rays."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17027] "A procedure used to examine the vagina, uterus, fallopian tubes, and bladder. An instrument is inserted into the vagina, and sound waves bounce off organs inside the pelvic area. These sound waves create echoes, which a computer uses to create a picture called a sonogram. Also called TVS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17028] "A test that produces pictures (scans) of internal parts of the body. The person is given an injection or swallows a small amount of radioactive material; a machine called a scanner then measures the radioactivity in certain organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17029] "A technique to create images of bones on a computer screen or on film. A small amount of radioactive material is injected into a blood vessel and travels through the bloodstream; it collects in the bones and is detected by a scanner."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17030] "An image of the liver created on a computer screen or on film. A radioactive substance is injected into a blood vessel and travels through the bloodstream. It collects in the liver, especially in abnormal areas, and can be detected by the scanner."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17031] "Having, relating to, or consisting of more than one individual, element, part, or other component; manifold. (dictionary.com)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17032] "Other; not the same one or ones already mentioned."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17033] "Having to do with the functions of the body. When used in the phrase \"physiologic age,\" it refers to an age assigned by general health, as opposed to calendar age."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17034] "ratio of the abdominal circumference at the navel to maximum hip and buttocks circumference; looks at the proportion of fat stored on your body around your waist and hip; carrying extra weight around the stomach is riskier for your health than carrying extra weight around the hips or thighs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17035] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17036] "Islands between the Caribbean Sea and the North Atlantic Ocean, east of Puerto Rico. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17037] "A country in Southeastern Europe, north of Greece. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17038] "An account of all reproductive events and problems a person has experienced. An important aggregate factor in epidemiological studies of women's health.  The concept usually includes the number and timing of pregnancies and their outcomes, the incidence of breast feeding, and may include age of menarche and menopause, regularity of menstruation, fertility, gynecological or obstetric problems, or contraceptive usage. (from On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17039] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17040] "Population-based studies that assess trends and associations between molecular and genetic factors, and a specific disease, such as cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17041] "Patients who have survived several years"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17042] "Survivor; one who lives through affliction."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17043] "A catalytic PROTEIN-TYROSINE KINASE domain found on the cytoplasmic beta-portion of receptors. Many growth and differentiation factor receptors contain this domain. It is critical for the signal transduction pathways required for mitogenesis, transformation, and cell differentiation. (Neuron 1992;9:383) EC 2.7.1.-."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17044] "A gene which produces an easily assayed phenotype.  Often used for expression studies of heterologous promoters."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17045] "The process by which foreign molecules are taken up by antigen presenting cells, proteolytically cleaved, and displayed on the cell surface in complex with MHC molecules."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17046] "The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (from MSH98)(From Rosen et al., Dictionary of Immunology, 1989)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17047] "A class of cell surface proteins that bind to extracellular polypepetide molecules triggering intracellular signaling pathways that activate various cellular responses such as cell proliferation and/or differentiation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17048] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17049] "A gene change in the body's reproductive cells (egg or sperm) that becomes incorporated into the DNA of every cell in the body of offspring; germline mutations are passed on from parents to offspring. Also called hereditary mutation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17050] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17051] "A country in Central Europe, southeast of Germany. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17052] "A country in Central Europe, south of Poland. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17053] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17054] "Encoded by over 300 Nuclear Receptor Genes (NR Superfamily), Nuclear Receptors (NRs) are ligand-dependent transcription factors: steroid, retinoid, vitamin D, TH, and orphan receptors (unknown ligands). Transducing hormone signals into gene transcription, NRs regulate development, pattern formation, cell proliferation, cell differentiation, and homeostasis in target tissues. NRs share a common organization: an (N) modulatory domain, a conserved central Cys-rich region of two C4 zinc fingers that bind to specific upstream ligand-responsive target DNA elements, and a (C) ligand-binding domain. Stabilizing hydrophobic zinc finger interactions contribute to DNA binding specificity, homodimerization, and interaction with other proteins. Ligand-bound NR conformation allows coactivator interaction with the hormone-binding domain that mediates interaction with heat shock proteins, cyclophilins, and hormone. (NCI)"                                             
[17055] "The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17056] "A polycyclic aromatic hydrocarbon-inducible cytochrome which is of significant clinical interest due to the large number of drug interactions associated with induction and inhibition of theophylline. Caffeine is considered to be a model substrate for this enzyme. It also metabolizes theophylline and antipyrene. Environmental factors including cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole produce increases in CYP1A2 activity. (Ann Pharmacother 1995;29:619-24) EC 1.-."                                                                                                                                                                                                                                                                                                                                                                                                                     
[17057] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17058] "Antigen Identified by Monoclonal Antibody Ki-67, encoded by the MKI67 gene, is a nuclear antigen expressed in proliferating cells but not in quiescent cells, and required for maintaining cell proliferation. Expression of this antigen occurs preferentially during late G1, S, G2, and M phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected. Consequently, the monoclonal antibody Ki-67 is used in tumor pathology to detect proliferating cells in neoplastic diseases. This antigen is located in the nucleus, predominantly localized in the G1 phase in the perinucleolar region. In the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes. This antigen contains 1 FHA domain. Two alternative splicing forms exist, Long and Short. (from Swiss-Prot)"                                                                                
[17059] "A component of the TFIID protein complex. DNA-binding TAFII250 contains one HMG box and two bromodomains that bind multiply acetylated Histone H4. TAFII250, contains serine/threonine kinase domains that autophosphorylate, and transphosphorylate the large subunit of TFIIF. TAFII250 is essential for progression of the G1 cell cycle phase and may link control of transcription to the cell cycle. (from SWISS-PROT P21675, OMIM 313650, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17060] "Encoded by glucocorticoid-inducible human NFKBIA Gene (NFKBI Family), 317-aa 36-kDa cytoplasmic I-Kappa-B-Alpha contains 5 ANK repeats that interact with p65 RELA C-terminal REL homology regions. By complexing with and trapping NFKB in the cytoplasm, unphosphorylated NFKBIA inhibits NFKB target gene transcription in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. NFKBIA tyrosine phosphorylation leads to dissociation from NFKB, disabling inhibition of NFKB DNA-binding. Stimulus-dependent IKBKA/IKBKB serine phosphorylation of NFKBIA results in polyubiquitination and for rapid degradation via the ubiquitin system. (NCI)"                                                                                                                                                                                                                                                                                                      
[17061] "The ubiquitous bZIP transcription factor Upstream Stimulatory Factor binds to many viral and cellular promoters.  USF consists of two related polypeptides USF1 and USF2.  USF function may support the host immune response by promoting MHC class I and class II antigen expression.  (from OMIM 191523, 600390 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17062] "A serine/threonine protein kinase involved in cell cycle control, Cdk4 may complex with D-type G1 Cyclins and belongs to the CDC2/CDKX subfamily.  CDK4/CDK6 phosphorylates Rb in early G1, displacing histone deacetylase and blocking transcriptional repression.  CDK4 is inhibited by p16 (Cyclin-Dependent Kinase Inhibitor-2). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17063] "Encoded by widely expressed, mitogenically induced, and cell cycle regulated human TIMP3 Gene (TIMP Family), 27-kD glycosylated TIMP-3 is an angiogenesis inhibitor containing 12 conserved cysteines, localized in the ECM, and similar to TIMP-1 and TIMP-2. TIMP-3 complexes with and inactivates matrix metalloproteinases, involved in extracellular matrix degradation. TIMP family members may possess selective affinities for matrix metalloproteinases. Likely part of acute response tissue-specific remodeling, TIMP-3 acts on MMP-1, -2, -3, -7, -9, -13, -14 and -15. The N-terminus inhibits MMPs; the C-terminus mediates specific molecular functions. TIMP3 inhibits VEGF-mediated angiogenesis; it blocks VEGF binding to VEGFR2. Gene mutations cause Sorsby fundus dystrophy. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                     
[17064] "The MRP1 Protein constitutes a multidrug resistance-associated plasma membrane drug-efflux pump, detectable in lung, testis, and peripheral blood mononuclear cells.  This transporter protein is similar to ABC superfamily of transport systems and is over expressed in a multidrug-resistant SCLC cell line.  (from OMIM 158343 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17065] "CBF is an alpha/beta heterodimeric transcription factor involved in the transcriptional regulation of several genes important in hematopoiesis.  The CBFalpha subunit binds directly to the enhancer core DNA sequence on target genes, whereas the beta subunit does not bind the DNA directly but increases the affinity and stabilizes the binding of the alpha subunit to the DNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17066] "ATF proteins have been reported to be able to bind with FOS proteins to form the AP-1 transcription factor (from Nature Cell Biol. 4: E131-E136, 2002 via OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17067] "ErbB4 heterodimerizes with other type I receptor tyrosine kinases. In the peripheral nervous system, ErbB4 helps regulate glial proliferation and acts as a signaling molecule at the neuromuscular junction. In the mature CNS, ErbB4 is expressed in cerebellar granule cells and in a subset of cells that also express the neurotransmitter: aminobutyric acid. ErbB4 is critical in cardiac development.  It is overexpressed frequently in several common solid tumours, including in breast cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17068] "Bound to NFKB1 or NFKB2 to form NFKB and trapped in the cytoplasm by IkB proteins (primarily through p65), p65 belongs to the Rel/Dorsal family. IKB kinases phosphorylate IkB and activate NFKB via destructive ubiquitination. Translocated, activate NFKB transcription factor binds the enhancer Kappa-B 5'-GGRNNYYCC-3' DNA motif, in immune response and acute phase reaction genes. (from SWISS-PROT Q04206, OMIM 164014, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17069] "APC protein is expressed in many tissues. The cytoplasmic APC complex may regulate cell adhesion or transmission of contact inhibition signals into cells. APC is associated with beta-Catenin, which binds and activates E-Cadherin that controls formation and maintenance of epithelial adherens junctions. The APC/ASEF/beta-Catenin complex regulates the actin cytoskeleton and cell morphology/migration. Inactivating mutations of APC cause accumulation of beta-Catenin, which binds TCF4 and increases transcription of target genes, e.g., c-MYC, and binds GSK3-beta in the WNT signaling pathway. APC is a nucleocytoplasmic shuttle protein. During mitosis, APC localizes to microtubule ends within kinetochores forming a complex with BUB1 and BUB3 checkpoint proteins. APC mutant cells form mitotic spindles with microtubules that ineffectively connect with kinetochores, leading to chromosomal instability and defective chromosome segregation. (from OMIM and NCI)"    
[17070] "Is a 37 kDa protein that expressed in many types of long-lived cells. Mcl-1 protein is found in mitochondrial and other membranes also. Mcl-1 appears to function as a repressor of apoptotic cell death. It interacts with Bax , a protein promoting cell death. Overproduction of Mcl-1 can delay cell death by apoptosis associated with growth factor withdrawal, overexpression of the myc oncogene , or treatment with cytotoxic agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17071] "Encoded by human EMS1 Gene, 550-amino acid Cortactin is an actin-binding protein involved in restructuring of the cortical actin cytoskeleton. Similar to murine Cttn, cytoplasmic Cortactin is located in cell-substratum contact areas and contains one SH3 domain that may bind to the cytoskeleton. Cortactin may organize epithelial cell structure; it regulates interactions between adherens junction components and interacts with the cytoskeleton. It may interact with SHANK2 and SHANK3 via its SH2 domain. A substrate for pp60v-SRC, Cortactin tyrosine phosphorylation may regulate cell growth. EGF enhances p85 phosphorylation and causes p80 to p85 conversion. Posttranslational modification of Cortactin coincides with redistribution to cell-matrix contact sites. Cortactin is degraded during apoptosis in a caspase-dependent manner.  (from Swiss-Prot, OMIM, and NCI)"                                                                                                
[17072] "Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of a 120-kD HIF1-alpha subunit complexed with a 91- to 94-kD HIF1-beta subunit."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17073] "A type I membrane protein, c-ROS tyrosine kinase is probably a cell growth- or differentiation factor receptor that belongs to the insulin receptor family, sevenless subfamily.  (from Swiss-Prot P08922 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17074] "Expressed in neural and neuroendocrine tissues by human RTN1 Gene (Reticulon Family), 3 isoforms (A, B, C) of Reticulon 1, with unique N termini, are localized to ER membranes and contain a reticulon domain and 2 large C-terminal hydrophobic domains. RTN1 may be involved in neuroendocrine secretion or membrane trafficking. RTN1-A is a 776-aa 135-kD Ser/Pro-rich protein that contains multiple potential phosphorylation sites; RTN1-B is 356-aa and RTN1-C is 208-aa. RTN1-A and RTN1-B are phosphorylated and expression of RTN1-C is strongly correlated with neuronal differentiation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                       
[17075] "The cell surface NKTR Protein is involved in the recognition of tumor cells by large granular lymphocytes, a subpopulation of white blood cells that kill tumor cells by an MHC-independent mechanism.  The protein contains a unique amino acid structure and an external cyclophilin-related domain.  (from OMIM 161565 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17076] "Cytochrome P450, Family 2, Subfamily C, Polypeptide 18, encoded by the CYP2C18 gene, is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17077] "MPL encodes the Thrombopoietin Receptor, a member of the cytokine receptor superfamily.  The mechanism by which TPO activates the TPOR appears similar to that of other hematopoietic cytokines that bind and induce receptor homodimerization.  TPO regulates the production of multipotent hematopoietic progenitor cells and platelets.  Lymphoid progenitors express IL7R and not MPL, whereas myeloid progenitors express MPL and not IL7R.  The receptor for thrombopoietin may also represent a regulatory molecule specific for TPOR-dependent immune responses.  TPOR contains two fibronectin type III-like domains and is a type I membrane protein.  Two isoforms, MPL-K and MPL-P, are produced by alternative splicing and are co-expressed.  (from OMIM 159530, SWISS-PROT P40238, and NCI)"                                                                                                                                                                                         
[17078] "RAB8 protein (MEL) contains the four GTP/GDP-binding sites present in all RAS proteins.  The putative effector-binding site of MEL is similar to that of RAB/YPT proteins.  However, MEL contains a C-terminal CAAX motif characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins.  Members of the RAS superfamily are small GTP/GDP-binding proteins.  RAB/YPT family proteins may play a role in transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane.  (from OMIM 165040 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                   
[17079] "A protein tyrosine kinase activated within seconds after crosslinking the mIg complex on B cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17080] "Like bcl-2 bcl-xL acts as a repressor of apoptosis .  bcl-xL mediates the closure of the mitochondrial porin channel VDAC and thus regulates the release of cytochrome c during apoptosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17081] "The BAX gene produces at least four proteins by alternate splicing: membrane-bound alpha and cytoplasmic beta, gamma, and delta; all bind and antagonize BCL2, which represses programmed cell death.  Pro-apoptotic BAX acts as a partner of BCL2, shows extensive homology with BCL2, and forms homodimers and heterodimers with BCL2.  Pro-apoptotic BAX and BAK proteins accelerate opening of the mitochondrial porin channel, VDAC.  BAX appears to interact, and cooperate, with the constitutive pro-apoptotic ANT mitochondrial protein within the pore complex to increase mitochondrial permeability, allowing cytochrome C passage and triggering cell death. Expression of BAX is a significant prognostic factor in patients with gastric lymphoma.  Its prognostic value increases significantly when studied in BCL2-negative patients.  (from OMIM 600040 and NCI)"                                                                                                                
[17082] "Proto-oncogene coding for the macrophage colony-stimulating factor 1 receptor, a receptor tyrosine kinase.  Homolog of the v-fms McDonough feline sarcoma oncogene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17083] "A group of DNA-binding proteins that contain zinc finger repeats and involves pattern formation process."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17084] "Formation of a chemical compound by enzymes, either in the organism (in vivo) or by fragments or extracts of cells (in vitro)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17085] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17086] "A group of three atolls in the South Pacific Ocean, about one-half of the way from Hawaii to New Zealand. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17087] "To teach with hands-on experience"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17088] "Diminished immune responsiveness to specific antigens; induced or programmed clonal lymphocyte anergy is believed to be the second major mechanism (after clonal deletion) of the development of self tolerance by the immune system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17089] "formation of blood platelets."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17090] "Any form of exercise or movement. Physical activity may include planned activity such as walking, running, basketball, or other sports. Physical activity may also include other daily activities such as household chores, yard work, walking the dog, etc. (from NIDDK Glossary; http://www.niddk.nih.gov/health/nutrit/pubs/glossary/glossaryintro.htm)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17091] "The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IgG whose Fc portion is intact. The effector cell is a \"killer\" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent. (MSH98) Cell-mediated killing of target cells by lymphocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17092] "An intracellular or extracellular function, activity, or process principally involving intracellular or extracellular components. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17093] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17094] "The failure of the immune system to respond to an antigen that previously caused an immune response."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17095] "The characteristics in behavior that a certain person has."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17096] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17097] "Activities designed to promote appropriate behavior, conduct, or action including time out, limits, and controls."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17098] "The circle of friends, family, and associates that provide love, care, and need gratification including church, school, and workplace. (OMS94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17099] "Uninsured Medical Expense; payment for the uninsured portion of regular medical expenses, such as co-payments, deductibles, and uncovered expenses. Uninsured medical expense encompasses a range of items that includes co-payments, medicine costs, uncovered procedures and conditions, as well as cash payments in lieu of health insurance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17100] "Individual; a single human being."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17101] "(guy-neh-KAH-lo-jist) A doctor who specializes in treating diseases of the female reproductive organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17102] "(noo-ROL-o-jist) A doctor who specializes in the diagnosis and treatment of disorders of the nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17103] "(NOO-ro-SER-jun) A doctor who specializes in surgery on the brain, spine, and other parts of the nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17104] "(pa-THOL-o-jist) A doctor who identifies diseases by studying cells and tissues under a microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17105] "Of or pertaining to the country as opposed to the city. (American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17106] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17107] "Chronological record of health and disease events of family members and ancestors. (WEBS84)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17108] "A native of the islands of the Pacific Ocean"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17109] "General term for proteins that have binding as a major function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17110] "Formation of organs during development."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17111] "Any tissue from a human fetus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17112] "A laboratory tissue staining procedure involving monoclonal or polyclonal antibodies that react with specific tissue antigens.  Initially used as a research tool, immunocytochemistry has become routine in diagnostic work-up of diseases in pathology. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17113] "RAEB: Electromagnetic radiation in the portion of the spectrum from about 380 nm (violet) to 800 nm (red)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17114] "A country in the Pacific, comprising a group of islands in the North Pacific Ocean, southeast of the Philippines. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17115] "Population groups with an increased likelihood of a disease or other health issue, eg smoking, drug use, teen pregnancy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17116] "A plan or course of action designed to influence and determine decisions and actions as related to health or disease in organizations. (WEBS84)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17117] "Thyroid Hormone Receptor Beta comprises at least two dimeric thyroid hormone receptor transcription factors expressed in liver and some other tissues.  The receptor encoded by gene ERBA2 (THR1, THRB) on chromosome 3 is one form of the thyroid hormone receptor beta. Separated from ERBA2 by 50-120 kb, the ERBA1 locus encodes a second beta form of the receptor.  (from OMIM 190160 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17118] "Methods for short or long term preservation of sperm cells, such as cryopreservation in liquid nitrogen. (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17119] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17120] "A group of islands in the South Pacific Ocean, about half way between Hawaii and New Zealand. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17121] "A group of islands in the South Pacific Ocean, about one-half of the way from Hawaii to New Zealand. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17122] "A condition in which antioxidant levels are lower than normal. Antioxidant levels are usually measured in blood plasma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17123] "Gene targeting is a technique that involves integration of an exogenous DNA sequence encoding a specific gene into the genome of an organism by homologous recombination."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17124] "The variable phenotypic expression of a gene depending on whether it is of paternal or maternal origin, which is a function of the methylation pattern. Imprinted regions are observed to be more methylated and less transcriptionally active. (Segen, Dictionary of Modern Medicine, 1992) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17125] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17126] "Adaptation of tumor cells to anticancer drugs in ways that make the drugs less effective."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17127] "gene product of the multidrug resistance gene mdr-1, believed to be a membrane spanning transporter that can pump a wide variety of cytotoxic agents out of the cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17128] "Cancer that continues to grow or spread."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17129] "A medical-surgical specialty concerned with the morphology, physiology, biochemistry, and pathology of reproduction in man and other animals, and on the biological, medical, and veterinary problems of fertility and lactation. It includes ovulation induction, diagnosis of infertility and recurrent pregnancy loss, and assisted reproductive technologies such as embryo transfer, in vitro fertilization, and intrafallopian transfer of zygotes. (From Infertility and Reproductive Medicine Clinics of North America, Foreword 1990; Journal of Reproduction and Fertility, Notice to Contributors, Jan 1979) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                    
[17130] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17131] "ABC transporters consist of two integral membrane proteins (permeases) each having six transmembrane segments, two peripheral membrane proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. The ATP-binding protein component is the most conserved, the membrane protein component is somewhat less conserved, and the substrate-binding protein component is most divergent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17132] "Length of time after treatment during which no cancer is found. Can be reported for an individual patient or for a study population."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17133] "Method of charging whereby a physician or other practitioner bills for each encounter or service rendered. In addition to physicians, other health care professionals are reimbursed via this mechanism. Fee-for-service plans contrast with salary, per capita, and prepayment systems, where the payment does not change with the number of services actually used or if none are used. (From Discursive Dictionary of Health Care, 1976) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17134] "A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17135] "Microscopy in which a probe systematically rides across the surface of a sample being scanned in a raster pattern. The vertical position is recorded as a spring attached to the probe rises and falls in response to peaks and valleys on the surface. A microcomputer keeps track of the vertical excursions as a function of the position of the probe in the horizontal plane and presents the sample's image. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17136] "Tests that determine the toxicity of a substance. These include tests of clinical drugs, foods, environmental pollutants, etc. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17137] "The ERBB2 Gene at 17q21.1 encodes ERRB2 Receptor Protein Tyrosine Kinase, a 185 kD type I membrane glycoprotein that controls cell growth with features similar to EGFR. Ligand binding increases phosphorylation of tyrosine residues. A potential heterodimer with ERBB3 and ERBB4 receptors, p185ERBB2 is an essential component of the heregulin/neuregulin receptor complex. ERBB2 homodimers do not bind heregulin but ERBB2/ERBB3 heterodimers do. Neuregulins do not interact with ERBB2 alone. The IL6 cytokine induces tyrosine phosphorylation of ERBB2 and ERBB3, but not EGFR. ERBB2 forms an IL6-dependent complex with the IL6R gp130 subunit resulting in MAPK activation. Expressed in fetal kidney and liver, herstatin is a 68 kD secreted product of an alternative ERBB2 transcript that retains intron 8. Herstatin binds p185ERBB2 as an inhibitor by disrupting ERBB2 dimers and reducing p185 tyrosine phosphorylation.  (from SWISS-PROT, OMIM and NCI)"                  
[17138] "The EGFR gene at chromosome 7p12.3-p12.1 encodes the EGF receptor, a cell surface transmembrane protein tyrosine kinase in regulation of cell growth and differentiation. The gene is not expressed in mitotically quiescent cells, except in the stomach where it controls the synthesis and release of digestive enzymes and gastric acid. EGFR has two components in different sizes. The tyrosine kinase activity is required for internalization or degradation of EGF-EGFR receptor complexes. EGFR signaling involves small RHO GTPases and EGFR trafficking involves small RAB GTPases. EPS8, a substrate of EGFR, connects these pathways. EPS8 is complexed with SOS1 by adaptor protein E3B1, mediating activation of RAC. Through its SH3 domain, EPS8 also interacts with RNTRE, a RAB5 GTPase-activating protein regulated by EGFR. By acting on RAB5, RNTRE inhibits EGFR internalization and diverts EPS8 from activating RAC, attenuating RAC signaling."                          
[17139] "Two ERBA proto-oncogenes located on separate chromosomes, encode ERBA alpha and ERBA beta, which are thyroid hormone receptors in the nucleus and bind DNA to activate transcription. Multiple thyroid hormone receptor (THR) genes may be encoded in the human genome and perhaps as many as five loci with varying expression in different tissues and stages of development. The ERBA1 gene at 17q11.2 encodes ERBA alpha-1, ERBA alpha-2, and ERBA alpha-3, each produced by alternative splicing. All ERBA1 transcripts are coordinately expressed. The ERBA2 gene at 3p24.3 encodes ERBA beta-1 and a neighboring gene encodes ERBA beta-2. The TH receptor expressed in the mammalian CNS and most other tissues (except liver) is encoded by ERBA1. The receptor present in liver (the major TH-responsive organ) and some other tissues is encoded by ERBA2. Point mutations in the ERBA2 gene are associated with generalized resistance to thyroid hormone."                             
[17140] "A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17141] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17142] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17143] "Nucleotide sequence variations that occur in the same region of DNA between individuals within a species, or between alleles in an individual that cause partially denatured DNA fragments to take on different conformations as a result of their nucleotide sequences differences.  These conformation differences can be detected through various gel-separation techniques"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17144] "ERBB DNA sequences are related to certain avian erythroblastosis virus sequences. The cellular genes encode members of the epidermal growth factor receptor (EGFR) family (ERBB1, 2, 3, and 4). The 110-kb EGFR gene locus encodes the EGF receptor, a cell surface transmembrane protein tyrosine kinase involved in regulation of cell growth and differentiation. ERBB2, ERBB3, and ERBB4 genes encode heregulin/neuregulin receptor tyrosine kinase homo- and heterodimers important in the control of cell proliferation and in the pathogenesis of human cancers. ERBB proteins are over expressed in a significant portion of adenocarcinomas at various sites, especially in the breast; gene amplification appears to be the predominant cause of over expression. Oncogene ERBB2 encodes tumor antigen p185. The human ERBB1 gene is located at 7p12.3-p12.1, ERBB2 is located at 17p12-21, ERBB3 is located at 12q13, ERBB4 is located at 2q33.3-q34."                                   
[17145] "Cytoplasmic proteins of both prokaryotes and eukaryotes that bind to nascent or unfolded polypeptides and ensure correct folding or transport. Chaperone proteins do not covalently bind to their targets and do not form part of the finished product. Heat-shock proteins are an important sub set of chaperones. Three major families are recognised, the chaperonins (groEL and hsp60), the hsp70 family and the hsp90 family. Outside these major families are other proteins with similar functions including nucleoplasmin, secB and T-cell receptor associated protein. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                       
[17146] "Heat Shock Protein 70 is a class of conserved molecular chaperone proteins in both prokaryotes and eukaryotic cells that may interact with polypeptides during the assembly processes to prevent the formation of nonfunctional structures.  There are at least three HSP70 loci in the human genome, which map to chromosomes 6, 14, 21, and at least one other chromosome.  Heat-shock proteins are expressed in response to a variety of stresses.  The human HSP70 multi-gene family encodes highly conserved 70 kD proteins with structural and functional properties in common, but which vary in their response to metabolic stress.  Some mRNAs are rapidly degraded through an AU-rich 3-prime untranslated region bound by AUF1, which complexes with HSC70, HSP70, EIF4G, and poly(A)-binding protein.  The mRNA decay is associated with displacement of EIF4G from AUF1, ubiquitination of AUF1, and degradation.  HSP70 blocks decay of AU-rich mRNAs and AUF1 protein."              
[17147] "The Heat Shock Protein 90 members HSP89-alpha and HSP89-beta are a class of cytoplasmic molecular chaperone homodimers that act in the signal transduction mechanism of steroid receptors and may have ATPase activity.  CDC37 and HSP90 associate preferentially with CDK4 not bound to type D cyclins.  HSPA8, HSP90A, CXCR4, and GDF5 on monocytes form an activation cluster after LPS ligation and are involved in LPS signal transduction.  (from OMIM 140571, Swiss-Prot P07900, P08238, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17148] "Cyclin-dependent kinases are eukaryotic, phosphoregulated protein kinases that associate with cyclins to control cell cycle progression.  (from MSH98 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17149] "Cellular morphology is the form and structure of cells, and its relation to cell function, or the scientific study thereof."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17150] "A sum of money or other resources set aside for a specific purpose. (American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17151] "Development is the act, or process, of natural progression in physical and psychological maturation from a previous, lower, or embryonic stage to a later, more complex, or adult stage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17152] "Chemical properties is a general term for the compositional, structural, and reactivity-affecting qualities of chemical compounds."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17153] "CD44, encoded by the CD44 gene and expressed as isoforms generated from alternative splicing and posttranslational modifications, is an acidic sulfated integral membrane glycoprotein that mediates cell-matrix adhesion, lymphocyte activation, lymph node homing, and immune cell cytokine release. Certain isoforms that regulate lymphocyte and macrophage activation and migration may enhance growth and metastatic spread of tumor cells, and may be useful in detection and diagnosis of cancer. Expressed on various cells, CD44 is the main receptor for hyaluronate. Hyaluronate enhances homotypic cellular aggregation while another ligand, osteopontin, induces cellular chemotaxis. CD44 functions in a growth factor presentation mechanism necessary for limb development. Streptococcus binding to CD44 on keratinocytes induces host cytoskeletal rearrangements and disruption of intercellular junctions, promoting tissue penetration by bacteria. (from OMIM and NCI)"     
[17154] "Arylamine N-acetyltransferase, the encoded product of the NAT2 gene, is the polymorphic enzyme responsible for the \"acetylator phenotype\"; rapid or slow acetylation of therapeutic and carcinogenic agents is due to variation at the NAT2 locus.  The slow phenotype results from decreased or absent arylamine N-acetyltransferase in the liver.  A relationship appears to exist between acetylator phenotype and DNA damage by chemicals that undergo N-acetylation.  Acetylation polymorphism may be a factor in susceptibility to toxicity and perhaps carcinogenicity of target chemicals.  (from OMIM 243400 and NCI)"                                                                                                                                                                                                                                                                                                                                                                   
[17155] "The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) Gene, a member of the GA733 gene family, encodes a type I membrane protein (with extracytoplasmic domain, transmembrane region, and cytoplasmic domain) that may function as a growth factor receptor. The TACSTD2 gene contains one thyroglobulin type-I domain and a single exon that encodes a predicted 35.7-kD protein with four potential N-linked glycosylation sites and a conserved potential cytoplasmic phosphorylation site. TACSTD2 is expressed in the cornea as well as in kidney, lung, placenta, pancreas, prostate, gastrointestinal tumors, and pancreatic carcinoma cell lines.  Deletion or truncation of the gene product appears to be associated with Gelatinous Drop-Like Corneal Dystrophy, an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment. The human gene is located at chromosome 1p32-p31 or 1p31-q12."                              
[17156] "Human telomeric-repeat binding factor proteins (TRF) 1 and 2 are involved in the control of telomere dynamics in vivo.  Reduced expression of TRF1 and TRF2 mRNAs was observed in human malignant hematopoietic and acute leukemia cell lines.  However, expression of TRF1 and TRF2 mRNAs increased during differentiation of malignant hematopoietic cell line when induced artificially.  Furthermore, studies from gastrointestinal carcinogenesis suggested that down-regulation of the TRF1 expression in tumor cells may be involved in cell immortalization. Together with hTERT, TRF1 and TRF2 are important regulators of telomerase activity and represent potential targets for cancer therapy."                                                                                                                                                                                                                                                                                        
[17157] "FAS differentiation antigen is expressed in the thymus, liver, ovary, and heart, and on a variety of cell lines including myeloid and lymphoblastoid cell lines. Its primary role is to regulate T-cell development in the thymus and to regulate peripheral immune responses, by triggering apoptosis.  FAS is a member of the TNFR/NGFR superfamily.  Activation of FAS by FAS ligand results in the formation of a death-inducing signaling complex with the signal adaptor protein FADD and with procaspase 8.  This association generates CASP8, activating a cascade of caspases.  (from MSH98, OMIM 134637, and NCI)"                                                                                                                                                                                                                                                                                                                                                                        
[17158] "BCL6 protein is may be a transcription factor and contains six zinc finger motifs and shares an N-terminal POZ domain homologous to other transcription factors. BCL6 protein is predominantly expressed in the B-cell lineage and found in mature B cells. BCL6 is expressed in germinal centers, including all centroblasts and centrocytes. BCL6 is present in DNA-binding complexes and can repress transcription and its activity is dependent upon DNA-binding and on the N-terminal region containing the POZ motif. Target genes have roles in B-cell activation (CD69, CD44, EBI2, ID2, LEU13, and STAT1), B-cell differentiation (BLIMP1, CD10, AMYB, BCL7A, CD19, and CD20), inflammation (MIP1A, IP10, and CXCR4), and cell cycle control (p27(KIP1) and cyclin D2). Expression of BCL6 in some B-cells early in the antigen response may skew them toward a germinal center fate, away from a plasma cell fate. (from OMIM 109565 and NCI)"                                            
[17159] "The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. This protein is a non-ATPase subunit of the 19S regulator. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (from LocusLink)"                                                                                                                                                                                                                                                                          
[17160] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17161] "Encoded by Human MAPK8 Gene (MAPK Family) as alternative isoforms (alpha-1, -2, beta-1, -2), MAP Kinase 8 is a stress/cytokine-induced Ser/Thr kinase that acts as an integration point for multiple biochemical signals involved in target transcription factor regulation, such as c-Jun and ATF2. Beta-1 binds c-Jun; alpha-1, -2, and beta-2 bind c-Jun or ATF2. Inhibited by dual specificity phosphatases, and phosphothreonine/tyrosine activated by a Ras-dependent dual specificity MAP2K4/MAP2K7 cascade, MAPK8 mediates immediate-early gene expression. MAPK8 binds scaffolding proteins MAPK8IP1/2/3. MAPK8/UV-induced apoptosis appears related to cytochrome c-mediated cell death. MAPK8 activation by TNF-alpha induces apoptosis. MAPK8 appears to be required for T-helper cell differentiation into Th1 cells. (NCI)"                                                                                                                                                           
[17162] "RRAD protein is a novel 29 kD member of the RAD/GEM family in the RAS-guanosine triphosphatase superfamily.  It is expressed in skeletal and cardiac muscle, lung, and lesser amounts in placenta and kidney.  RRAD is selectively over expressed in type II diabetic muscle as compared to muscle of non-diabetic or type I diabetic individuals.  (from OMIM 179503, SWISS-PROT P55042, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17163] "The CDKN1A gene encodes a cyclin-dependent kinase inhibitor 1A product, which inhibits cyclin kinase activity and may be the p53 effector of cell cycle control.  This gene is transcriptionally regulated by p53 and IFN beta.  The human gene is located at 6p21.2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17164] "May mediate p53 inhibition of cell proliferation in response to DNA damage. CIP1 appears to be a tight-binding inhibitor of CDKs. CDKN1A expression is tightly regulated by p53 and IFN-Beta. The CIP1 N-terminus is similar to KIP1. CIP1 is truncated by CASP3 in apoptosis. (from SWISS-PROT P38936, OMIM 116899, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17165] "Induced by TGF-beta, cyclin-dependent kinase 4 inhibitor B interacts with CDK4 and CDK6, and may mediate TGF-Beta induced cell cycle arrest.  CDK4IB contains two ankyrin repeats and belongs to the CDKN2/p16(INK4) family.  (from SWISS-PROT P42772, OMIM 600431, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17166] "A hetero-dimeric (catalytic/regulatory subunits) serine/threonine protein kinase involved in cell cycle control. Predominantly neuronal, Cdk5 belongs to the CDC2/CDKX subfamily, interacts with D1- and D3-type G1 Cyclins, and phosphorylates histone H1, Tau, Map2, NF-H, and NF-M. (from SWISS-PROT Q00535, OMIM 123831, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17167] "Product of the CDKN2A gene.  Also called p16(INK4).  A tumor suppressor and a negative regulator of progression through G1.  p16(INK4) interacts with CDK4/CDK6, inhibiting their interaction with Cyclin D and the phosphorylation of RB."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17168] "Antibodies or parts of antibodies found in unusually large amounts in the blood or urine of people with multiple myeloma."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17169] "CXCR4 shares features common to G protein coupled receptors.  CXCR4 is a receptor for the CXC chemokine PBSF/SDF1 and functions as a co-receptor for HIV-1.  CXCR4 is broadly expressed in the immune and the central nervous systems and can mediate migration of resting leukocytes and hematopoietic progenitors in response to SDF1.  PBSF/SDF1 and CXCR4 define a signaling system for organ vascularization.  (from OMIM 162643 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17170] "Maspin is a member of the Serpin protein family. Unlike other members of the family, Maspin exhibits no protease inhibitory activity (see J Biol Chem. 2002 Dec 6;277(49):46845-8. Epub 2002 Oct 15), but it plays a role in cell-matrix adhesion, tumor invasion, and metastasis.  High maspin expression appears to oppose lymph node metastasis.  Higher expression is associated with better survival rates and may be a favorable prognostic marker. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17171] "DAN protein (Differential screening-selected gene Aberrant in Neuroblastoma) is a putative transcription factor that may prevent cells from entering final G1/S stage.  (from OMIM 600613 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17172] "Collagen XVIII (Alpha 1), encoded by the human COL18A1 gene, is the alpha chain of type XVIII collagen. Mutations in this gene are a cause of Knobloch syndrome. The main features of this syndrome involve retinal abnormalities and this protein may play an important role in retinal structure and in neural tube closure. There is an association between a polymorphism in position 1437 and prostate cancer. Three transcripts have been identified for this gene as a result of alternate promoter utilization and alternative splicing. A long variant predominates in liver, while a short variant is present in conventional basement membranes. This protein is present in multiple organs with highest levels in liver, lung and kidney. The proteolytically produced C-terminal fragment of Collagen XVIII (Alpha 1) is endostatin, a potent antiangiogenic protein. (From LocusLink, Swiss-Prot, and NCI)"                                                                           
[17173] "Growth Arrest and DNA-Damage-Inducible, Alpha, encoded by the GADD45A gene, is widely expressed in normal tissues and its expression is increased by DNA damage. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. The GADD45A protein responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. This nuclear protein interacts with the proliferating cell nuclear antigen (PCNA), a component of DNA replication/repair complexes, and the cyclin dependent kinase inhibitor p21Cip1."                                                                                                                                                                                                                                                                                                                                                                                              
[17174] "MLH1 protein is a DNA-binding, DNA-mismatch repair protein, of the MutL/HexB family, that dimerizes with PMS2 or MLH3.  MLH1 is part of the multi-subunit BASC repair complex containing ATM, BLM, MSH2, MSH6, BRCA1, the RAD50/MRE11/NBS1 complex, and the RFC1/RFC2/RFC4 complex.  MLH1 is homologous to MutL, which hydrolyzes ATP.  (from OMIM 120436 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17175] "The Drosophila gene Imitation SWI (Iswi) encodes a DNA helicase involved in chromatin modeling. It contains a SNF2 related domain, a MYB DNA binding domain, a DEAD/DEAH box helicase, and a helicase C-terminal domain. Iswi is a component of NURF, a nucleosome remodeling complex that facilitates the perturbation of chromatin structure in an ATP-dependent manner. The hydrolysis of ATP during the remodeling of chromatin is mediated by Iswi. It is also a component of the ATP-utilizing chromatin assembly and remodeling factor ACF and of the chromatin accessibility complex CHRAC. This subunit serves as the energy-transducing component of chromatin-remodeling machines. NURF is composed of a 215 kD protein, Iswi, nurf-55, and nurf-38. Iswi belongs to the SNF2/RAD54 helicase family, SNF2L subfamily. (from FlyBase 0011604 and NCI)"                                                                                                                                    
[17176] "A transmembrane glycoprotein present in tumor-associated vasculature but not associated with normal or benign tissue.  PSMA can serve as a tumor marker as well as a target for therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17177] "Merlin protein (schwannomin, NF2 gene product) exhibits similarity to erythrocyte protein 4.1 and members of the ERM family (moesin, ezrin, and radixin), proteins thought to link cytoskeletal components with cell membrane proteins.  Mutant merlin proteins alter cell adhesion, causing cells to detach from the substratum, a possible step in the pathogenesis of NF2.  Merlin binds to the ERM-interacting phosphoprotein EBP-50.  Merlin may maintain normal cytoskeletal organization.  Schwannomin interacts with the HGF-regulated tyrosine kinase substrate HRS.  Schwannomin and HRS co-localize at endosomes suggesting that schwannomin is involved in HRS-mediated cell signaling.  (from OMIM 101000 and NCI)"                                                                                                                                                                                                                                                                    
[17178] "TEL protein is a member of the ETS family of transcription factors.  It has an HLH motif and an ETS DNA-binding domain.  Translocations of the gene produce chimeric proteins in many leukemias of myeloid or lymphoid origins.  Leukemogenic translocations often fuse the TEL HLH domain with the tyrosine kinase domain of other genes, such as PDGFRB, NTRK3, and ABL2 or with other transcription factors, such as AML1 and ARNT.  (from OMIM 600618 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17179] "An inducible cell surface glycoprotein.  It is expressed on fibroblasts in many common epithelial cancers.  It is a gelatinase belonging to the serine protease family.  It is the target of BIBH 1 monoclonal antibody."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17180] "TNFR1 is a 55 kD high-affinity cell surface receptor for tumor necrosis factor.  Activated receptor interacts with death domains of TRADD to activate apoptosis and NFKB cascades.  TRADD-interacting FADD proteolytically activates caspase-8.  TNFR1 may activate PIP5K2B and may induce MAP kinase activation via MADD.  (from OMIM 191190 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17181] "Encoded by human TOP2A Gene (TOPII Family), alternative homodimeric nuclear DNA Topoisomerase II, Alpha isoforms 1 (1531-aa, 174.4-kD), 2 (1557-aa), 3 (1567-aa), and 4 (1612-aa) control DNA topology. TOP2A catalyzes transient ATP-dependent double-strand breakage/relaxation and rejoining of negative/positive supercoiled DNA during transcription, replication, chromosome condensation, and chromatid separation. TOPII reactions likely involve crossing-over. TOP2A is associated with Pol II holoenzyme. Inhibited by intercalating amsacrine, TOP2A is a target for several anticancer agents. Mutations are linked with drug resistance and perhaps ataxia-telangiectasia. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                               
[17182] "Both topo II alpha and beta isoforms exhibit ATP-dependent strand passage activity, but they differ in several key aspects.  The beta isoform relaxes DNA in a more progressive manner than the alpha isoform and also exhibits a higher optimal KCl requirement.  The beta isoform has a molecular weight of 180 KD, and is immunologically distinct as well as exhibits different SV8 proteolytic cleavage pattern from alpha isoform."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17183] "CREB-binding protein, a 265 kD member of a family of transcription factor co-activators now referred to as p300/CBP.  Originally identified as a nuclear protein bound by the Protein Kinase A-phosphorylated form of CREB (cAMP responsive element binding protein)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17184] "Important in cell proliferation and differentiation, E1A-Associated p300 Protein is a histone acetyltransferase and transcriptional co-activator/integrator that regulates transcription via chromatin remodeling. p300 contains a bromodomain, a KIX domain, and three Cys/His-rich regions. A compact IBID domain in p300 participates in ligand binding and contributes to signal integration by p300. LIF and BMP2 cytokines signal through STATs and SMADs, respectively, and act in synergy on progenitor cells to induce astrocytes. p300 interacts with STAT3 in a cytokine-independent fashion, and with SMAD1 in a cytokine-dependent manner. The formation of a p300-bridged complex between STAT3 and SMAD1 mediates cooperative LIF/BMP2 signaling and astrocyte induction. p300 also facilitates DNA repair by PCNA via chromatin remodeling at DNA lesions. p300 forms an S phase-independent complex with PCNA that stimulates DNA synthesis. (from OMIM 602700 and NCI)"           
[17185] "Encoded by human PRKCA Gene (PKC Family), 672-aa 77-kDa Protein Kinase C-alpha is a calcium-activated (likely by the C2 domain), DAG-activated, phospholipid-dependent serine/threonine kinase containing 2 zinc-dependent phorbol-ester/DAG binding domains and a C2 domain that phosphorylates a range of cellular proteins. DAG markedly increases PKC sensitivity to calcium and phospholipids. PKC activation appears to be central in the induction of cellular responses to many ligand-receptor systems and to external stimuli. After GPCR stimulation, and triggered by PKC-dependent serine phosphorylation, RKIP dissociates from RAF1 to associate with and block GRK2 activity. By activating PKC, the receptor signal may be enhanced by removing a RAF1 inhibitor and blocking receptor internalization. A receptor for phorbol ester tumor promoters, PKC may interact with PRKCABP. (NCI)"                                                                                        
[17186] "ETV3 Protein, a member of the ETS proto-oncogene family of transcription factors, contains the conserved ETS domain that mediates sequence-specific DNA binding.  (from OMIM 164873 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17187] "Expressed in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus, and kidney epithelia, human PRSS8 Gene (Peptidase S1 Family) encodes secreted or membrane anchored 343-aa 36-kD (precursor) Serine Protease-8, similar to acrosin, plasma kallikrein, hepsin, and xCAP1 (Xenopus). The proprotein is cleaved (aa 12-13) to produce disulfide-linked light and heavy chains. The C terminal hydrophobic region is cleaved (aa 290-291) during secretion. Likely involved in semen coagulation and liquefaction, PRSS8 is active with trypsin-like specificity on Lys or Arg carboxyl peptide linkages. Prostasin may regulate ENaC. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                              
[17188] "A component of the RAS intracellular signaling pathway, MAP2K1 is a critical activiting protein kinase of MAP kinase.  p53 activates NFKB through a RAF/MAP2K1/p90(RSK) pathway.  (from Yu et al. Curr Biol 1998. 8:56, OMIM 176872, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17189] "Kangai 1 Protein, a metastasis suppressor protein encoded by the 80 kb human KAI1 gene (TM4SF family), is expressed in many tissues and has four putative transmembrane domains and a large extracellular domain having three potential N-glycosylation sites. KAI1 appears to be up regulated in activated T-cells. p53 activates the gene by interacting with sequences in a 5-prime upstream region. Loss of p53 appears to cause down-regulation of KAI1. Similar to leukocyte cell surface glycoproteins involved in cell adhesion and signal transduction, KAI1 is a likely homologue of mouse leukocyte surface antigen R2. Associated with CD4 or CD8, KAI1 delivers co-stimulatory signals for the TCR/CD3 pathway. KAI1 expression at the transcription or posttranscription level is often down regulated during tumor progression. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                    
[17190] "A DNA-binding, transcriptional activator with a possible role in proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells. A-Myb specifically recognizes the DNA sequence 5'-YAAC(G/T)G-3' and belongs to the Myb family. (from SWISS-PROT P10243, OMIM 159405, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17191] "The H4 gene is found fused to the RET Gene in papillary thyroid carcinoma and to platelet-derived growth factor receptor betaR in atypical chronic myeloid leukemia. The H4 gene shows no significant homology to known genes, and the function of H4 protein is unknown.  An N-terminal leucine zipper mediates dimerization of H4 protein and this dimerization is essentail to transforming activity. (from OMIM 601985 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17192] "TRAF2 is a homo- or (with TRAF1) heterodimer adaptor protein for TNFR1, TNFR2, and CD40 that mediates activation of NFKB.  TRAF2 contains a TRAF motif known to bind kinases involved in TRAF-mediated signaling, a Zn RING finger, and cysteine/histidine-rich motifs.  E2F1 can down regulate TRAF2 and inhibit anti-apoptotic NFKB signals.  (from OMIM 601895 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17193] "EAR2 protein is an ERBA-related protein similar in primary structure to the receptors for steroid hormones and thyroid hormone.  EAR2 is highly expressed in the fetal liver.  (from OMIM 132880 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17194] "A product of the von Hippel Lindau tumor suppressor gene, Elongin Binding Protein (VHL) is a general transcription elongation factor that increases the rate at which RNA polymerase II transcribes DNA by suppressing polymerase pausing.  VHL is part of a complex (VCB) that includes elongin B, elongin C, and cullin-2, proteins associated with transcriptional elongation and ubiquitination.  VHL directly interacts with, and inhibits, SP1.  VHL inhibits expression of hypoxia-inducing VEGF and GLUT1 genes.  (from OMIM 193300 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17195] "BRCA1, which functions as a tumor suppressor in human breast cancer cells, is a nuclear phosphoprotein which associates with RNA polymerase II holoenzyme. Mutations in BRCA1 are predicted to be responsible for approximately 45% of inherited breast cancer and more than 80% of inherited breast and ovarian cancer. BRCA1 may function as a transcriptional regulator, due to an amino terminal DNA-binding ring finger motif, nuclear localization signals, and an acidic carboxy terminal domain. BRCA1 is also a granin-like protein that functions as a secreted growth inhibitory protein. BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth. This function is compromised in breast cancer either by direct mutation or by alterations in gene expression. BRCA1 participates in transcription-coupled repair of oxidative DNA damage. (LocusLink)"                                                                                                     
[17196] "(der-ma-TAH-lo-jist) A doctor who specializes in the diagnosis and treatment of skin problems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17197] "(en-do-krih-NAH-lo-jist) A doctor who specializes in diagnosing and treating hormone disorders."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17198] "(GAS-tro-en-ter-AHL-o-jist) A doctor who specializes in diagnosing and treating disorders of the digestive system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17199] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17200] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17201] "(on-KOL-o-jist) A doctor who specializes in treating cancer.  Some oncologists specialize in a particular type of cancer treatment.  For example, a radiation oncologist specializes in treating cancer with radiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17202] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17203] "(OAT-oh-LAR-in-GOL-uh-jist) A doctor who specializes in treating diseases of the ear, nose, and throat. Also called an ENT (ear, nose, and throat) doctor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17204] "(RAY-dee-OL-o-jist) A doctor who specializes in creating and interpreting pictures of areas inside the body. The pictures are produced with x-rays, sound waves, or other types of energy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17205] "A dentist with special training in surgery of the mouth and jaw."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17206] "(yoo-RAHL-o-jist) A doctor who specializes in diseases of the urinary organs in females and the urinary and sex organs in males."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17207] "Cataloging, grouping, and flagging data for ready retrieval"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17208] "Various phenomena that occur in living organisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17209] "The medical specialty that focuses on tumors of the reproductive tract of women."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17210] "(guy-neh-ko-LAH-jik on-KOL-o-jist) A doctor who specializes in treating cancers of the female reproductive organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17211] "(hee-ma-TOL-o-jist) A doctor who specializes in treating diseases of the blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17212] "A specialist in internal medicine"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17213] "(ray-dee-AY-shun on-KOL-o-jist) A doctor who specializes in using radiation to treat cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17214] "A health professional who gives radiation treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17215] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17216] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17217] "The study of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17218] "(on-KOL-o-jist) A doctor who specializes in diagnosing and treating cancer using chemotherapy, hormonal therapy, and biological therapy. A medical oncologist often is the main caretaker of someone who has cancer and coordinates treatment provided by other specialists."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17219] "Intervention studies in which surgery is the dominant feature to prevent, diagnose, stage, or treat cancer (except neurosurgery and eye surgery).  Includes special devices for dividing or destroying tissues, development and improvement of instruments for detection and diagnosis of tumors where surgery/biopsy is the dominant feature, cytoreductive procedures, intraoperative radiotherapy, surgical treatment of cancer and its complications, surgical supportive care, and plastic reconstructive and rehabilitation surgery."                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17220] "A doctor who performs biopsies and other surgical procedures in cancer patients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17221] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17222] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17223] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17224] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17225] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17226] "Ambulatory and capable of all self-care but unable to carry out any work activities. Up and about more than 50% of waking hours  (Eastern Cooperative Oncology Group)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17227] "Capable of only limited self-care, confined to bed or chair more than 50% of waking hours. (Eastern Cooperative Oncology Group)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17228] "Completely disabled. Cannot carry on any self-care. Totally confined to bed or chair  (Eastern Cooperative Oncology Group)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17229] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17230] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17231] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17232] "The medical specialty that focuses on tumors in children."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17233] "Oncologists who specialize in treating children"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17234] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17235] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17236] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17237] "A surgeon who specializes in reducing scarring or disfigurement that may occur as a result of accidents, birth defects, or treatment for diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17238] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17239] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17240] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17241] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17242] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17243] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17244] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17245] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17246] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17247] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17248] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17249] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17250] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17251] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17252] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17253] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17254] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17255] "MART-1 (Melanoma Antigen Recognized by T cells, also called Melan-A) is a self antigen expressed on melanocytes and the retina.  It is an 18kDa melanocyte differentiation antigen.  It is also expressed on the surface of most melanomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17256] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17257] "An island group in the North Pacific Ocean, about three-quarters of the way from Hawaii to Indonesia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17258] "A country in the Pacific, comprising islands in the North Pacific Ocean, about three-quarters of the way from Hawaii to the Philippines. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17259] "Surgery that does not alter the course of a disease, but improves the quality of life."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17260] "Island in the Caribbean Sea, north of Venezuela. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17261] "Islands in the Caribbean Sea, about one-third of the way from Puerto Rico to Trinidad and Tobago. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17262] "Meta-analysis is a set of statistical procedures designed to accumulate experimental and correlational results across independent studies that address a related set of research questions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17263] "The inevitable variety in customs, attitudes, practices, and behaviors that exists among groups of individuals from different ethnic, racial, or national backgrounds who come into contact."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17264] "A constellation of responses that occur when an organism is exposed to excessive heat and other environmental stresses. Responses include synthesis of some proteins, repression of other proteins, and expression of new proteins. (From Segen, Dictionary of Modern Medicine, 1992)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17265] "immunity induced by the mucosal IgA response for specific resistance toward bacteria, viruses, and parasites infecting the respiratory, gastrointestinal, or genitourinary tracts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17266] "test for the presence and specificity of DNA binding proteins and their binding sites on DNA, based on their tendency to prevent DNA cleavage by restriction enzymes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17267] "Neural Cell Adhesion Molecule is a membrane-bound glycoprotein member of the Ig superfamily that binds to a variety of other cell adhesion proteins involved in diverse contact-mediated interactions.  NCAM appears on early embryonic cells and is important in the formation of cell collectives at sites of morphogenesis.  Later it is found on differentiated neurons, astrocytes, oligodendrocytes, and myotubes and mediates neuronal adhesion, guidance, and differentiation.  NCAM plays a role in cell-cell and cell-matrix adhesion through homophilic and heterophilic binding.  The invertebrate cell adhesion molecules fasciclin II (grasshoppers and Drosophila) and apCAM (Aplysia) are related to NCAM and can mediate homophilic cell aggregation.  Four main isoforms exist, including CD56, but many variants result from alternative splicing and post-translational modifications.  (from OMIM 116930 and NCI)"                                                             
[17268] "Imaging Phantoms are used for the assessment of image quality.  Within these functional categories phantoms can be further defined.  (1) Body Phantoms: have the shape and composition of the human body or part of it.  They are also referred to as anthropomorphic phantoms.  (2) Phantoms that are used for standardization and inter-comparison of various radiation conditions are often referred to as Standards.  (3) Reference Phantoms include phantoms used to derive radiation dose calculations, mineral density equivalences or other similar type measurements.  They can further be defined by their intended modality such as Ultrasound, Mammography, Computed Tomography (CT), etc."                                                                                                                                                                                                                                                                                             
[17269] "Family of non-receptor protein-tyrosine kinases homologous to src. They are closely related intracellular enzymes that participate in signal transduction pathways in a variety of hemopoietic cells and especially their surface receptors. EC 2.7.1.-."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17270] "A chemical process in which oxygen is used to make energy from carbohydrates (sugars)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17272] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17273] "A family of cell adhesion molecules containing a lectin-like domain, an EGF-like domain, and domains homologous to complement-binding proteins.  Selectins mediate leukocyte binding to the vascular endothelium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17274] "An antibody that prevents some reaction from taking place, for example one antibody competing with another for a cell surface receptor. (from On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17275] "Encoded by the HCK proto-oncogene, HCK appears to be a SRC-family tyrosine kinase, expressed primarily in hematopoietic cells, especially of myeloid lineage and particularly in mature granulocytes and monocytes.  HCK deletions may contribute to some acute myeloid leukemias and myeloproliferative disorders.  (from OMIM 142370 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17276] "C/EBP epsilon is a CCAAT enhancer-binding protein and bZIP transcription factor uniquely expressed in, and essential for differentiation of, granulocytic progenitor cells.  C/EBP epsilon forms homo- or heterodimers with other family members and expression is enhanced by retinoids.  Four isoforms are expressed from different promoters and an alternate start codon.  (from OMIM 600749 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17277] "Involved in G1 arrest, nuclear CDKN1B inhibits bound cyclin/CDK complexes and negatively regulates cell cycle progression. CDKN1B, a CASP-3 apoptotic target, is phosphorylated by CCNE1/CDK2, ubiquitinated by SKP2, and degraded.  CDKN1B expression is regulated by PI3K/PKB and RAS/RAL regulated AFX-like forkhead proteins.  Immunohistochemical detection of p27Kip1 may help to identify patients with gastric carcinomas, without lymph node involvement, who are at high risk of death.  Low CDKN1B expression is strongly associated with a with poor prognosis.  (from Int J Oncol 2001. 18:151, Cancer 2000. 89:2247, SWISS-PROT P46527, OMIM 600778, and NCI)"                                                                                                                                                                                                                                                                                                                        
[17278] "Paired basic amino acid cleaving enzyme is an ubiquitous proprotein endoprotease that functions within secretory pathways and is localized in the trans Golgi network.  PACE cleaves protein substrates at RX(K/R)R consensus motifs and plays a significant role in tumor progression.  (from OMIM 136950 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17279] "NFAT is a multi-subunit transcription complex that includes homo- or hetero-dimers of FOS and JUN proteins.  NFATC, the Dorsal/Rel family cytosolic component of NFAT, is translocated to the nucleus following TCR-induced PKC stimulation and calmodulin-dependent calcineurin-mediated dephosphorylation.  Phosphoprotein NFATP, the 'preexisting component' of NFAT present in the unstimulated T-cell cytosol, locates in the nucleus as part of NFAT after activation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17280] "Ubiquitous nuclear and cytoplasmic RNA Binding Protein EWS belongs to the TET family of RNP proteins, contains an RNA recognition motif and a RANBP2-type zinc finger, and may function as a repressor.  EWS contains a transcription activation domain, but the RNA-binding domain can repress trans-activation by the activation domain.  The RNA-binding activity is localized to a C-terminal RGG box.  EWS binds RNA, calmodulin, and the RNA polymerase II 33 kD polypeptide (RPB3), but not RPB5 or RPB7.  EWS interacts with FAK2 and relocates from cytoplasm to ribosomes upon FAK2 activation.  Two isoforms of the EWS protein are produced by differential splicing.  (from SWISS-PROT Q01844 and NCI)"                                                                                                                                                                                                                                                                                
[17281] "ELK3 Protein, an ELK subfamily member of ETS-related DNA-binding transcription factors, is highly expressed at early stages of B-lymphocyte development, declining upon cell maturation.  ELK3 may play a role in B-cell development and Ig gene regulation.  (from OMIM 600247 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17282] "Term used to denote the class of sequence-specific DNA-binding proteins that contain the bHLH domain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17283] "TRADD is an adaptor protein involved in the recruitment of FADD or TRAF signaling proteins into TNF-stimulated cell death or NFKB induction.  TRADD contains a death domain, similar to that of TNFR1, capable of mediating TRADD oligomerization, interaction with the TNFR1 death domain, stimulation of apoptosis, and NFKB activation.  TNF-induced apoptosis involves TRADD-mediated ICE cysteine protease activation.  NFKB activation by TRADD involves a different pathway.  (from J Leukoc Biol 1998. 63:678, OMIM 603500, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17284] "Isolated as a gene in a region frequently deleted in colorectal carcinomas, the DCC gene encodes DCC Protein, which has sequence similarity to cell adhesion molecules such as N-CAM and may participate with other proteins in cell-cell and cell-matrix interactions. It is a transmembrane protein of the immunoglobulin superfamily, is expressed on spinal commissural axons and possesses netrin-1-binding activity. Knockout studies in mice failed to support a tumor-suppressor function for DCC in the mouse, but were consistent with the hypothesis that DCC is a component of the receptor for netrin-1, a neuronal chemoattractant. (from OMIM)"                                                                                                                                                                                                                                                                                                                                      
[17285] "An antigenic dimeric combination of intermediate filament Keratin 8 and Keratin 18 peptides, K8/K18, which is detectable in serum and is being investigated as a cancer marker."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17286] "38kD fragment of plasminogen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17287] "Polo-like kinase is a serine/threonine protein kinase involved in mitosis and required for spermatogenesis.  By phosphorylation of the cyclin B1 nuclear export signal, PLK1 may target mitosis-promoting factor to the nucleus during prophase, which is essential for induction and coordination of M-phase.  Localized to centrosomes, centromeres/kinetochores, and the spindle midzone, PLK may regulate organization and function of the mitotic apparatus.  (from OMIM 602098 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17288] "Found only in the cytosol, TP53BP2 impedes cell cycle progression beyond G2/M.  It enhances p53 trans-activation function and induces p21 (CDKN1A) expression.  TP53BP2 contains ankyrin repeats and an SH3 domain, required for interaction with p53 and BCL2; TP53BP2 cannot bind both proteins simultaneously.  (from OMIM 602143 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17289] "Tuberin has sequence similarity to the GTPase-activating protein GAP3 and may regulate cell growth.  It specifically stimulates the GTPase activity of RAS-related RAP1A protein, but not of RAP2, H, RAC, or RHO.  Tuberin exhibits GAP activity (mediated by rabaptin-5) towards RAB5, a critical docking and fusion component of the endocytic pathway.  (from OMIM 191092 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17290] "RecQL protein is a 13,3 kD peptide (1208 aa), belongs to the RecQ subfamily of helicases and contains from aa 476 to 824 an helicase domain with a potential ATP binding site from aa 502 to 509, and the DEAH box from aa 605 to 608.  The expression of RecQ4 gene is partially upregulated in the G1/S phase of cell cycle. It suppresses promiscuous genetic recombination and ensures accurate chromosome segregation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17291] "Product of the SMARCB1 gene, hSNF5/INI1 protein is a member of the multi-protein SWI/SNF chromatin-remodeling complex that opens chromatin to facilitate target access by the transcription machinery.  Two isoforms of hSNF5/INI1 are produced by alternative splicing.  (from OMIM 601607 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17292] "BRCA2 putatively functions as a tumor suppressor gene, however, its exact function has not been well characterized. The similarity of, and functional analysis of, BRCA2 and BRCA1 proteins, suggests that these proteins function in the same genetic pathway. BRCA1 and BRCA2 have transcriptional activation potential and the two proteins are associated with the activation of double-strand break repair and/or homologous recombination. The two proteins have been shown to coexist and colocalize in a biochemical complex. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17293] "Eukaryotic initiation factor-3 (eIF3) is the largest of the eIFs and consists of at least ten non-identical subunits in mammals.  eIF3S6 (p48) appears to interact with eIF3-p170.  eIF3S6 binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA.  Cytoplasmic eIF3 is ubiquitously expressed.  (from Swiss-Prot Q64252 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17294] "Expressed in early myeloid cells, peripheral mononuclear cells, and in ovary, kidney, and lung by retinoic acid induced human ZNF145 Gene (Krueppel Family), alternative isoforms PLZFA (550-aa) and PLZFB (673-aa, 74-kDa) of nuclear Zinc Finger Protein 145 are probable transcription factors containing a BTB/POZ domain. Conserved N-terminal protein interaction BTB/POZ domains of some C2H2 transcription factors interact with components of histone deacetylase complex and repress transcription. ZNF145 may play a role in myeloid maturation and development, or maintenance of differentiated tissues. A growth-inhibitory and pro-apoptotic factor in limb bud formation, ZNF145 is an axial and appendicular skeletal anterior/posterior patterning mediator that regulates HOX gene expression. APL associated translocation t(11;17)(q32;q21) involves ZNF145 and RARA. (NCI)"                                                                                                   
[17295] "Human WNT7A protein is an homologue of the Drosophila wingless segment polarity gene product.  WNT7A is a cysteine-rich extracellular matrix intercellular signaling glycoprotein implicated in the regulation of cell fate and patterning during embryogenesis.  Gene expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.  WNT7A guides development of the female reproductive tract and controls limb development at the dorsoventral axis.  (from OMIM 601570 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17296] "ALCAM is a cell adhesion molecule expressed on mitogen-activated leukocytes and monocytes, fibroblasts, neurons, and tumor-derived cell lines but not on unactivated leukocytes.  ALCAM is a ligand for CD6, a receptor expressed on T-cells involved in cell adhesion interactions between thymocytes and thymic epithelial cells.  ALCAM/CD6 interactions may play a role in the binding of T- and B-cells to activated leukocytes.  ALCAM has five Ig domains and its amino acid sequence has significant homology to chicken neural adhesion molecule BEN/SC-1/DM-GRASP.  (from OMIM 601662 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                           
[17297] "A member of the VAV oncogene family, VAV2 is a probable exchange factor for a RAS-like GTP-binding protein and responds to a cell surface receptor tyrosine kinase.  Integrin-induced phosphorylation of VAV2 requires SYK.  VAV2 contains a calponin-homology domain, a DBL-homology domain, a PH domain, a DAG binding domain, an SH2 domain, and SH3 domains.  (from OMIM 600428 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17298] "Somatostatin binds to a group of structurally related tissue-specific high-affinity integral membrane GPCRs (family 1), coupled via G proteins to inhibition of adenylyl cyclase.  Somatostatin Receptor 2 is expressed highest in the cerebrum and kidney and inhibits DNA synthesis and cell proliferation.  SSTR2 appears to antagonize SSTR5, and vice versa, suggesting a tissue-specific function and interaction between these receptors.  SSTR2 stimulates phosphotyrosine phosphatase and PLC via G proteins.  It also appears to suppress voltage dependent calcium-channels.  Two isoforms are produced by alternative splicing.  (from OMIM 182452, SWISS-PROT P30874, and NCI)"                                                                                                                                                                                                                                                                                                        
[17299] "A 74 kDa serine/threonine kinase originally identified by its ability to associate with Fas/APO-1 and induce cell death.  RIP interacts with the cytoplasmic domain of FAS, and with TNFR1 through the adaptor proteins TRADD and TRAFs 1, 2, and 3."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17300] "Ataxia Telangiectasia Mutated Protein, encoded by the ATM gene, belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates and functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, which results in a defect in cell cycle regulation and DNA repair. Mutations are also associated with sensitivity to DNA damaging agents such as ionizing radiation. At least 3 alternatively spliced transcript variants encoding distinct isoforms, have been identified. (from LocusLink)"                               
[17301] "Interferon regulatory factor 4 is a transcriptional activator that binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter and to the immunoglobulin lambda light chain enhancer, together with PU.1.  IRF4 probably plays a role in the ISRE-targeted signal transduction mechanisms of lymphoid cells.  Two isoforms are produced by alternative splicing.  (from OMIM 601900 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17302] "Somatostatin binds to a group of structurally related tissue-specific high-affinity integral membrane GPCRs (family 1), coupled via G proteins to inhibition of adenylyl cyclase.  The Somatostatin Receptor 5 and D2R GPCRs interact to create a novel receptor with enhanced activity; either ligand promotes heterodimerization.  SSTR5 increases DNA synthesis, whereas SSTR2 inhibits DNA synthesis and cell proliferation.  SSTR2 appears to antagonize SSTR5, and vice versa, suggesting a tissue-specific function and interaction between these receptors.  SSTR5 is expressed in adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus.  (from OMIM 182455, SWISS-PROT P35346, and NCI)"                                                                                                                                                                                                                                                        
[17303] "Mitosin is a nuclear matrix homo- or heterodimeric protein that is associated with kinetochores from the onset of M phase to metaphase, with accumulation mitosin peaking in G2/M phase.  It is rapidly degraded after mitosis.  Mitosin may be involved in chromosome segregation and kinetochore function.  It interacts with RB, CENP-E, and BUBR1.  (from SWISS-PROT P49454, OMIM 600236, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17304] "NRIP1associates directly with a transcriptional activation domain of ESR in the presence of estrogen and modulates transcriptional activation by the receptor. (from OMIM 602490, Swiss-Prot P48552, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17305] "1. any response of the immune system to an antigen including antibody production and/or cell-mediated immunity; 2. the response of the immune system to an antigen (immunogen) that leads to the condition of induced sensitivity; the immune response to the initial antigenic exposure (primary immune response) is detectable, as a rule, only after a lag period of from several days to two weeks; the immune response to a subsequent stimulus (secondary immune response) by the same antigen is more rapid than in the case of the primary immune response."                                                                                                                                                                                                                                                                                                                                                                                                                                
[17306] "The cytotoxicity of cells depending on antibody recognition.  The killing of a target cell by a killer cell by means of an antibody directed to the target by the antigen-binding arms and anchored to the killer cell via an Fc receptor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17307] "(an-gee-o-GEN-eh-sis) Blood vessel formation. Tumor angiogenesis is the growth of blood vessels from surrounding tissue to a solid tumor. This is caused by the release of chemicals by the tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17308] "Oxidation, breakdown, and synthesis of carbohydrates in the tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17309] "The act of puffing and/or inhaling smoke from a lit cigarette, cigar, or pipe."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17310] "1D1; Basic Sciences Research (includes vaccine and chemotherapy development); Therapeutic Agents (antiviral, antimicrobial, immunomodulating and antineoplastic agents); Development. Physical or chemical agents that may improve the health of a patient by impeding cancer or other diseases"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17311] "A flavoprotein acting on NADPH and using quinone as acceptor. Inhibited by dicoumarol. [EC 1.6.99.2 created 1961 as EC 1.6.5.2, transferred 1965 to EC 1.6.99.2]. (from IUBMB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17312] "Any multicellular process of immune cells effecting or involved with the immune response or immune maintenance. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17313] "Inherited; having to do with information that is passed from parents to offspring through genes in sperm and egg cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17314] "An inherited increase in the risk of developing a disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17315] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17316] "Contact with infectious agents (bacteria or viruses) in a manner that promotes transmission and increases the likelihood of disease. (CDC)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17317] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17318] "The form and structure of organisms (plants, animals, and other forms of life), or of their parts, and the study or science of the same.  In pathology, the specific appearance of cells and tissues (normal and abnormal) under the light or electron microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17319] "The process by which non-govt. companies obtain and do work for the Federal government"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17320] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17321] "A medical practitioner whose primary concern is the health status of the population within a defined geographic area, who is usually responsible for assessment and evaluation of the community's health needs and for the organisation of health services to meet those needs. He will generally not render primary health care, except for specific disease entities such as selected communicable diseases. His role varies from country to country, but he is usually employed by a government agency."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17322] "(pros-tho-DON-tist) A dentist with special training in making replacements for missing teeth or other structures of the oral cavity to restore an individual's appearance, comfort, or health."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17323] "A prosthesis placed permanently in tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17324] "An individual who currently, or recently, smokes cigarettes regularly."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17325] "Ashkenazi Jews, also called Ashkenazim, are Jews who are descendants of Jews from Germany, Poland, Austria and Eastern Europe."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17326] "A gene found in some types of tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17327] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17328] "A demographic parameter indicating the number of years of schooling or the highest level of achievement at school."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17329] "Islands in the South Atlantic Ocean, east of southern Argentina. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17330] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17331] "Aromatase is a unique member of the cytochrome P450 enzyme superfamily that catalyzes formation of aromatic C18 estrogens from C19 androgens by desaturating ring A of the steroid.  One of two components of the aromatase enzyme complex, aromatase is present in many tissues including skin, muscle, fat, and nerve, where it may contribute to sex-specific differences in cellular metabolism.  The other component of aromatase is NADPH-cytochrome P450 reductase, which transfers reducing equivalents to P450(arom).  Class I cytokines such as IL6 and IL11, as well as TNF-alpha, are important regulatory factors of the CYP19 (aromatase) gene.  (from OMIM 107910 and NCI)"                                                                                                                                                                                                                                                                                                          
[17332] "All or part of the research on a grant to a US institution is either conducted in a foreign country; uses foreign subjects or their tissues or medical data; or involves collaboration with foreign researcher(s). (RAEB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17333] "A noninvasive tool used to observe functioning in the brain or other organs by detecting changes in chemical composition, blood flow, or both."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17334] "Rehabilitation nursing is a specialty devoted to assisting individuals of all ages and cultural backgrounds to accomplish the tasks of daily living to their greatest potential and return to their premorbid lifestyle. (ARN)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17335] "A computer environment in which multiple linkages enable users to move directly from one segment of audio, video, graphic, or text to another in a database."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17336] "DNA methylation is a biological process involving the enzymatic addition of methyl groups to DNA by DNA methyltransferases (DNA methylases); S-adenosylmethionine is the methyl group donor.  An ancestral mechanism for neutralizing potentially damaging DNA elements in the prokaryotic genome, in eukaryotic vertebrates DNA methylation appears to play a regulatory role in gene expression.  (MSH98 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17337] "A computer-controlled presentation of some combination of audio, video, animation, graphics, still photo, and/or text where users can control the presentation and often interact with it."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17338] "The BCL-2 gene encodes two isoforms from alternative splicing of the mitochondrial membrane protein BCL-2, which exhibits anti-apoptotic activity promoted by growth factor-stimulated phosphorylation by PKC. Cleavage of BCL-2 by caspases during apoptosis yields a pro-apoptotic product that stimulates further caspase activity, due to release of mitochondrial cytochrome C into the cytosol. Gene transcription is up regulated by IL2. BCL-2 consists of two exons separated by an intron. The first exon is transcribed into a 3.5 kb mRNA, spliced to produce a 5.5kb mRNA. These mRNAs encode alpha and beta isoforms, identical except for the carboxyl terminus. Overexpression of BCL-2 from a t(14;18) translocation with the Ig gene region promotes B-cell lymphomas, due to interference with apoptosis. The human gene is located at 18q21.3."                                                                                                                                 
[17339] "Bioinformatics derives knowledge from computer analysis of biological data. These can consist of the information stored in the genetic code, but also experimental results from various sources, patient statistics, and scientific literature. Research in bioinformatics includes method development for storage, retrieval, and analysis of the data. Bioinformatics is a rapidly developing branch of biology and is highly interdisciplinary, using techniques and concepts from informatics, statistics, mathematics, chemistry, biochemistry, physics, and linguistics. It has many practical applications in different areas of biology and medicine. (M. Nilges and Jens P. Linge, Unite de Bio-informatique Structurale, Institut Pasteur, Paris)"                                                                                                                                                                                                                                        
[17340] "A gene on chromosome 17 that normally helps to suppress cell growth. A person who inherits an altered version of the BRCA1 gene has a higher risk of getting breast, ovarian, or prostate cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17341] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17342] "Mammalian P-glycoproteins are encoded by the MDR gene family and belong to the ATP-binding cassette vectorial transport protein class; the CFTR chloride channel is also a family member.  The human multidrug resistance 1 (MDR1) gene responds to environmental stress, including various anticancer agents.  It is a major determinant in the development of resistance to a large number of cancer chemotherapeutic agents.  MDR1 and MDR2 P-glycoproteins are large apical cell membrane proteins overproduced in multidrug-resistant (MDR) cancer cells resistant to diverse hydrophobic drugs.  P-glycoproteins act as pumps able to extrude drugs from cells at the cost of ATP hydrolysis.  MDR is primarily due to increased drug extrusion from the resistant cell.  Defense against xenobiotics may be a natural function of these P-glycoproteins."                                                                                                                                    
[17343] "The line was derived from the CV-1 cell line (ATCC CCL-70) by transformation with an origin defective mutant of SV40 which codes for wild type T antigen. The cells contain a single integrated copy of the complete early region of the SV40 genome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17344] "KU80 protein is the 80 kD subunit of the KU autoantigen, a heterodimeric DNA repair complex that binds DNA double-strand breaks, is the DNA-binding component of the DNA-dependent protein kinase, and facilitates repair by nonhomologous end-joining.  KU70 and KU80 form a dyad-symmetrical molecule with a preformed ring that encircles duplex DNA.  KU protein is also involved in V(D)J recombination.  KU is identical to DNA helicase II, an ATP-dependent DNA unwinding enzyme.  (from OMIM 194364 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17345] "A transcription factor that belongs to the AP-2 family and binds viral and cellular enhancers containing the consensus 5'-GCCNNNGGC-3' DNA motif. AP-2 Beta appears to regulate expression of genes required for ectodermal development and retinoic acid-induced differentiation of neuroectodermal cells. (from SWISS-PROT Q92481, OMIM 601601, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17346] "Caveolin 1 (CAV1), encoded by the CAV1 gene, is a scaffolding protein and the main component of the caveolae plasma membranes found in most cell types. CAV1 and CAV2 form Caveolin, a stable hetero-oligomeric complex important in the formation and maintenance of caveolae. In the absence of caveolin no morphologically identifiable caveolae exist, with one exception where in neuronal cells CAV 1 and CAV 2 are expressed but there are no morphologically recognizable caveolae. Caveolin 1 links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. Caveolin expression is correlated both to oncogenic transformation and its reversal. CAV1 is a tumor suppressor candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. Alternative splicing results in 2 isoform proteins (alpha, beta). (NCI)"                                                                  
[17347] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17348] "Human LMO2 Gene (LMO family) at 11p13 encodes Rhombotin 2, which functions in hematopoiesis.  Part of a multi-protein transcription regulatory complex that includes GATA-1, rhombotin 2 binds to TAL1 protein and interacts with RB binding protein-2, enhancing transcription.  Chromosomal translocations of LMO2 are associated with T-cell leukemias. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17349] "Rhombotin 2, an LMO (LIM-only) family member that functions in hematopoiesis, is encoded by the LMO2 gene. With two LIM domains and a cysteine-rich motif, rhombotin 2 is part of a multi-protein transcription regulatory complex that includes GATA-1. LMO2 protein binds to the bHLH TAL1 protein and interacts with retinoblastoma binding protein-2, enhancing transcription. Chromosomal translocations involving LMO2 are associated with T-cell leukemias.  (from OMIM 180385 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17350] "Gene product of the FLT1 proto-oncogene.  A receptor tyrosine kinase, thought to regulate endothelial cell-cell or cell-matrix interactions during vascular development."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17351] "This is a 60 kD protein containing a Dbl-homology domain, which is shared by several signal transducing molecules implicated as regulators of small GTP-binding proteins. TIM is thought to be involved in control of cytoskeletal organization through regulation of small GTP-binding proteins.  (from OMIM 600888 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17352] "Nuclear Receptor Coactivator 1 is a co-activator for the full transcriptional activity of ligand-activated PGR, ESR, GRL, THR, and RXRA through their DNA response elements. SRC1 can also enhance the transcriptional activity of SP1, but not E2F, E47, or CREB. SRC1 has a glutamine-rich and a serine/threonine-rich region. SRC1 can also bind to TBP and to TFIIB, in addition to nuclear hormone receptors in a ligand-dependent manner; SRC1 may bridge nuclear hormone receptors with general transcription factors. Studies suggest a dual role for SRC1 in chromatin remodeling and in recruitment/stabilization of general transcription factors.  (from OMIM 602691 and NCI)"                                                                                                                                                                                                                                                                                                          
[17353] "Kinase involved with apoptosis regulation in multiple myeloma.  Regulated by IL-6 and SHP-2 phosphatase"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17354] "epithelial membrane protein-1.  Thought to be involved in cell-cell interactions and the control of cell proliferation. Found to be highly expressed in brain tumor cells but not in normal brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17355] "BLM protein is a glycopeptide of 417 amino acids within which ATP binding domain is in amino acid 689-696, DEAH box in 795-798, and 2 putative nuclear localization signals in the C-term in 1334-1349.  It is expressed at high level in S phase, and persists in G2/M and sharply declines in G1.  It function as a 3'-5'DNA helicase, and probably plays a role in DNA replication and repair.  It participates in a supercomplex of BRCA1 -associated proteins named BASC (BRCA1-Associated genome Surveillance Complex)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17356] "Cyclin B1 is essential for control of the G2/M transition and the gene is expressed predominantly in the G2/M phase of cell division.  Complexed with p34(cdc2), cyclin B1 forms mitosis-promoting factor (MPF), a serine/threonine kinase holoenzyme complex.  Cyclin B1 imparts substrate specificity to MPF. Phosphorylation of cyclin B1 regulates nuclear translocation of MPF during prophase, essential for the induction and coordination of M-phase events.  During cell cycle progression, a change in PLK1 kinase activity appears to phosphorylate cyclin B1 and stimulate nuclear entry of cyclin B1. (from SWISS-PROT P14635, OMIM 123836, and NCI)"                                                                                                                                                                                                                                                                                                                                  
[17357] "The SMAD4 tumor suppressor protein specifically recognizes an eight base pair palindromic DNA sequence and is critical for transmitting TGFB, and related cytokine signals, to the cell nucleus to mediate transcriptional activation of target genes.  The MADH4 gene is a cloned gene for Juvenile Polyposis, associated with colon cancer.  (from OMIM 600993 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17358] "G(s) alpha is a subunit of the heterotrimeric G(s) protein.  G(s) alpha couples hormone-receptor binding to adenylyl cylase activity and cAMP signaling."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17359] "A rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins, COX-2 is expressed in cells involved in inflammatory processes and has been implicated in tumor promotion as well as a negative prognosis.  COX-2 is expressed in 50% of pancreatic tumors.  Anti-inflammatory glucocorticoids are potent inhibitors of cyclooxygenase.  Inhibition or lack of COX-2 reduces tumor growth and blocks angiogenesis.  Aspirin and etodolac, both COX-2 inhibitors, inhibit growth of pancreatic cancer cell lines.  (from Cancer 2001. 91:333, Medscape, OMIM 600262, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                       
[17360] "CKR5 is a G protein coupled receptor for beta-chemokines.  It also functions as a co-factor for macrophage-tropic HIV-1 infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17361] "MDC-15; ADAM-15; metargidin.  Member of a sequence-related family of cysteine-rich membrane proteins containing metalloproteinase-like and disintegrin-like domains; contains an RGD sequence in its disintegrin domain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17362] "Somatostatin binds to a group of structurally related tissue-specific high-affinity integral membrane GPCRs (family 1), coupled via G proteins to inhibition of adenylyl cyclase.  Somatostatin Receptor 4 is specifically expressed in human fetal and adult brain, lung, and stomach, and less in kidney, pituitary, and adrenals.  SSTR4 also activates arachidonate release and the MAP kinase cascade.  (from OMIM 182454, SWISS-PROT P31391, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17363] "Essential for control of the G1/S transition, cyclin D1 interacts with CDK4 and CDK6 to form a serine/threonine kinase holoenzyme and imparts substrate specificity to the complex.  RB regulates cyclin D1 gene expression.  Cyclin D1 expression may identify Barrett's esophagus patients at high risk for esophageal carcinoma; risk of progression to adenocarcinoma exhibits an odds ratio of 6.85.  The BCL1 and PRAD1 oncogenes involve cyclin D1 gene translocations.  (from J Natl Cancer Inst 2000. 92:1282 & 1316, SWISS-PROT P24385, OMIM 168461, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                            
[17364] "An adenovirus nuclear membrane glycoprotein synthesized from the E3 transcription unit in large amounts late in infection.  It is required for efficient lysis of infected cells.  It is being investigated for use in targeting tumors for death by a suicide mechanism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17365] "CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation. p300/CBP-Associated Factor, encoded by the PCAF gene, displays in vivo binding activity with CBP and p300. This protein has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that it plays a direct role in transcriptional regulation. It also associates with NF-kappa-B p65. Protein kinase A regulates the transcriptional activity of NF-kappa-B by modulating its interaction with CPB/p300. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                            
[17366] "Encoded by human SAT Gene, 171-aa 20-kDa cytoplasmic Spermidine/Spermine N1-Acetyltransferase is a highly regulated homotetrameric rate-limiting enzyme in the catabolic polyamine metabolism pathway that regulates intracellular polyamine concentration and polyamine transport out of cells. SAT acts on putrescine, spermidine, spermine, N(1)-, and N(8)-acetylspermidine and catalyzes N(1)-acetylation of spermidine and spermine. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17367] "RAEB: The study of the internal workings of cells at the microscopic and molecular level."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17368] "State of the body in relation to the consumption and utilization of nutrients. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17369] "A history of daily food intake"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17370] "using a beam of visible light and optical magnification to image a specimen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17371] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17372] "Protected against infectious disease by either specific or non-specific mechanisms. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17373] "Used for Cancer Activities Coding when cancer activity is not specified."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17374] "Pictures of structures inside the body. Scans often used in diagnosing, staging, and monitoring disease include liver scans, bone scans, and computed tomography (CT) or computerized axial tomography (CAT) scans and magnetic resonance imaging (MRI) scans. In liver scanning and bone scanning, radioactive substances that are injected into the bloodstream collect in these organs. A scanner that detects the radiation is used to create pictures. In CT scanning, an x-ray machine linked to a computer is used to produce detailed pictures of organs inside the body. MRI scans use a large magnet connected to a computer to create pictures of areas inside the body."                                                                                                                                                                                                                                                                                                                
[17375] "A system for classifying cancer cells in terms of how abnormal they appear when examined under a microscope. The objective of a grading system is to provide information about the probable growth rate of the tumor and its tendency to spread. The systems used to grade tumors vary with each type of cancer. Grading plays a role in treatment decisions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17376] "Acquisition or display of radiographic images using digital techniques; includes digital video fluorscopy, scan-projection radiography (SPR), digital subtraction and angiography (DSA), digital intravenous angiography (DIVA), and computed tomography. (CRC Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17377] "Home; one's place of residence. (Merriam Webster WWW Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17378] "Necessary to maintain life. Breathing is a vital function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17379] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17380] "3-D. A graphic display of depth, width, and height."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17381] "Studies show that the ST7 gene is widely expressed and often disrupted by mutation or deletion in tumors arising from epithelial cells, such as breast, prostate, colon and ovary.  The gene is predicted to encode a highly conserved protein, with orthologous sequences in mouse, cow, pufferfish, and C. elegans.  Such conservation suggests a critical role for ST7, as is the case for most tumor suppressor genes.  (from OMIM 600833 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17382] "The continent lying mostly south of the Antarctic Circle. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17383] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17384] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17385] "Bottles utilized as vessels for intermediate scale preparations of attachment-dependent cultured cells.  Denoted 'roller bottles' because they are slowly rotated, or rolled, to permit homogeneous cell growth on all the available inner surface of the bottle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17386] "Immunology is the study of the immune system and its reaction to pathogens, as well as its malfunctions (autoimmune diseases, allergies, rejection of organ transplants). (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17387] "Alteration of any condition or process in an offspring that results form the effect of a carcinigen in a parent.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17388] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17389] "(FEE-kul o-KULT) A test to check for blood in stool. (Fecal refers to stool; occult means hidden.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17390] "(FOS-fa-tays) PAP. An enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17391] "genetic phenomenon due to deletion or mutation in one allele of a polymorphic gene, as detected by expression after cell fusion; used as a test for tumor-promoting mutations; do not confuse with \"loss of heterogeneity\" which applies to diverse cell populations within a tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17392] "The T-cell antigen receptors consist of a heterodimer of integral membrane glycoproteins. Two distinct receptors exist, alpha/beta and gamma/delta. Alpha/beta receptors are found on helper and cytotoxic T-cells and are specific for antigenic peptides presented in association with MHC gene products. Gamma/delta receptors, found in association with CD3, directly recognize proteins and non-proteinacious phospho-ligands. Alpha/beta and gamma/delta are non-covalently associated with CD3-gamma, -delta, -epsilon, and -zeta proteins, forming the TCR-CD3 complex, which activate MAPKs and JNK1 through the CD3 antigens, the adaptor protein LAT, and tyrosine kinases LCK and ZAP70. The genes for T-cell receptor subunits are encoded by distict gene elements that are assembled by somatic rearrangement during T-cell development. Translocations and inversions of these loci are observed in human T-cell leukemias and lymphomas."                                         
[17393] "Encoded by Chemokine Receptor Genes (GPCR Family), cell surface Chemokine Receptors are seven-transmembrane G protein-coupled receptor glycoproteins that bind to chemokines and mediate the migration of pro-inflammatory cells. Like chemokines, the chemokine receptors can be divided, according to variations in a shared cysteine motif, into at least three structural branches: CR, CCR, and CXCR. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17394] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17395] "A method used to identify a disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17396] "The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. (LocusLink)"                                                                                                                     
[17397] "This gene at 9p21 encodes p16 (a cyclin dependent kinase inhibitor) and p14 (an upstream regulator of p53) via alternative promoters and splicing. The unitary inheritance of p16 and p14 may promote cooperation in cell cycle control through their relations to the RB and p53 growth control pathways. p16 gene regulation by ETS is potentiated by RAS-RAF-MEK kinase signaling and inhibited by the HLH protein ID1. Bound to CDK4, p16 inhibits CDK4 interaction with cyclin D and passage through late G1. It inhibits RB phosphorylation by CDK4 and CDK6. Bound to MDM2, p14 promotes MDM2 degradation and blocks MDM2-induced p53 degradation, leading to p53 stabilization and accumulation. CDKN2A disruptions such as chromosomal inversions, translocations, and deletions are associated with malignancies and in a variety of malignant cell lines from glioma, nonsmall cell lung cancer, leukemia, melanoma and tumors of the breast, bone, skin, bladder, kidney, and ovary."   
[17398] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17399] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17400] "FHIT protein is a 147-amino acid AP3A hydrolase.  The FHIT preferred substrate, AP3A (diadenosine 5-prime,5-triple prime-P(1),P(3)-triphosphate), and AP4A have been proposed to have various intracellular functions, including regulation of DNA replication and signaling stress responses. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17401] "FER (FPS/FES related) protein is a tyrosine kinase expressed in lymphoid cells; phosphoprotein NCP94.  Inhibition of CDH2 (the cytoplasmic domain) or of beta-1 integrin function results in release of FER from the cadherin complex and accumulation in the integrin complex, suggesting that FER may shuttle between cadherin and integrin complexes, perhaps mediating cross-talk between CDH2 and ITGB1.  (from OMIM 176942 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17402] "Part of the heterodimeric transcription factor Core-Binding Factor.  CBF beta does not bind to DNA directly, but increases the affinity and stabilizes the binding of the CBF alpha (transcription factor AML1) for the CBF enhancer/promoter DNA site in TCR genes.  CBF appears to regulate hematopoietic differentiation.  Disruption of CBFB is associated with some leukemias.  (from SWISS-PROT Q13951, OMIM 121360, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17403] "This protein is a telomere specific binding protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17404] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17405] "Phosphatase involved in apoptosis regulation in multiple myeloma.  Normally activated by IL-6, it regulates the activity of RAFT Kinase"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17406] "Caspase-3, encoded by the CASP3 gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Caspase-3 is a central player in mediating apoptosis and is the most widely studied caspase. This protein cleaves and activates caspases 6, 7 and 9, and itself can be processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of the CASP3 gene results in two transcript variants which encode the same protein. (From LocusLink and NCI)"                                                                                    
[17407] "This protein is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. This protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform which is truncated at the N-terminus as compared to the full-length protein. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17408] "A member of the GLI family of Kruppel-related DNA-binding proteins, the 77 kD HKR3 Protein contains eleven C2H2 zinc fingers, an N-terminus tramtrack-associated box, and an acidic activation domain.  (from OMIM 165270 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17409] "Regulated by TGF-beta receptors, Mothers Against Decapentaplegic Homolog 3 is an effector of the TGF-beta response.  MADH3 is associated with and phosphorylated by the ligand-bound receptor complex.  MADH3 and MADH4 synergize to induce strong TGF-beta-like responses.  SMAD3 and SMAD4 proteins specifically recognize an eight base pair palindromic DNA sequence that confers TGF-beta responsiveness to a minimal promoter. (from OMIM 603109 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17410] "Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. Thish protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17411] "Normally expressed in all hematopoietic lineages, except T-cells, the ETS-domain PU.1 Transcription Factor is essential for development of myeloid (osteoclast progenitors) and B-lymphoid cells.  Graded PU.1 expression appears to specify distinct cell fates in the hematopoietic system; a low concentration induces the B-cell fate, while a high concentration promotes macrophage differentiation.  PU.1 is thought to regulate transcription of FMS and CD18/11B, proteins central to the osteoclast phenotype, and is required for p47-phox promoter activity in myeloid cells.  PU.1 expression is increased with the induction of osteoclastogenesis by 1, 25-dihydroxyvitamin D3.  (from OMIM 165170 and NCI)"                                                                                                                                                                                                                                                                         
[17412] "EXT2 is a presumed tumor suppressor.  EXT1 and EXT2 proteins are type II transmembrane glycoproteins that appear to form a heterooligomeric complex having glycosyl transferase activity involved in heparan sulfate polymerization.  EXT2 interacts with a UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase.  EXT1 and EXT2 proteins may play a role in modulation/diffusion of hedgehog signaling.  EXT2 is involved in hereditary multiple exostoses.  (from OMIM 133701 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17413] "Thrombospondin 2 is a secretory product of platelet alpha-granules and a product of many other cells.  It is a multifunctional protein that contains binding sites for thrombin, fibrinogen, heparin, fibronectin, plasminogen, plasminogen activator, collagen, laminin, etc.  It functions in many cell adhesion and migration events, including platelet aggregation and granule cell migration during histogenesis of the cerebellar cortex.  Two cysteine residues are involved in interchain disulfide linkage and trimer assembly.  Cells express both homotrimeric and heterotrimeric forms of the protein (with THBS1).  (from OMIM 188061 and NCI)"                                                                                                                                                                                                                                                                                                                                       
[17414] "A fragment of cytokeratin 19.  A tumor marker.  Reported to be a sensitive serum marker of recurrent breast cancer.  May also be a good prognostic marker, with patients with high serum levels of the marker having shorter disease-free survival. (from Cancer 2000;89:1285-1290 via Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17415] "Fusion protein containing the helix-loop-helix domain of TEL, a member of the ETS-like family of transcription factors, and the DNA-binding and transactivation domains of the transcription factor AML1.  Encoded by the TEL-AML1 gene, which arises from a chromosomal translocation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17416] "Thymosin Beta-15 (Thymosin-Beta Family) may be an actin-binding protein and positive cell motility factor that opposes the activity of motility suppressor KAI1. Involved in metastasis and prostate cancer, TMSB15 may be a new target for therapy. (from OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17417] "Encoded by human ANGPT1 Gene, Angiopoietin-1 is a 498-amino acid 57.5 kD (precursor) secreted glycoprotein ligand for the endothelial TIE2 receptor tyrosine kinase and contains a predicted coiled-coil domain and a fibrinogen-like C-terminus.  Its expression in endothelial and early hematopoietic cells suggests an action in vascular development.  Antagonized by Angiopoietin-2, ANGPT1 structure differs from other angiogenic factors or ligands for receptor tyrosine kinases and its actions are distinct from VEGF, necessary for early stages of vascular development.  ANGPT1 acts in vascular remodeling, maturation, and stability.  ANGPT1 and TIE1 are critical for right side, but not left side, venous system development.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                                    
[17418] "Somatostatin binds to a group of structurally related tissue-specific high-affinity integral membrane GPCRs (family 1), coupled via G proteins to inhibition of adenylyl cyclase.  Somatostatin Receptor 3 is readily detected in brain, pituitary, and pancreatic islets.  (from OMIM 182453, SWISS-PROT P32745, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17419] "CDC6 Cell Division Cycle 6 Homolog, encoded by the CDC6 gene, is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cycle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cycle is regulated through its phosphorylation by Cdks. Transcription of this protein is regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                   
[17420] "Caspase-1, encoded by the CASP1 gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interlukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of the similar gene in mouse suggested its role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. (From LocusLink)"                                                
[17421] "A drug that is being studied for its ability to prevent the growth of new blood vessels into a solid tumor.  Endostatin belongs to the family of drugs called angiogenesis inhibitors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17422] "Globin gene expression is regulated through NFE2 elements upstream of alpha- and beta-gene clusters.  NFE2 DNA-binding involves a heterodimer containing a ubiquitous small MAF protein (MAFF, MAFG, or MAFK) and tissue-specific p45 NFE2.  Both subunits are members of the AP-1-like superfamily of bZIP proteins.  MAFG also forms heterodimers with NRF1 and NFE2-related factor 2, which stimulate transcription from NFE2 sites.  (from OMIM 602020 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17423] "A Kruppel family protein, GLI2 Protein contains five DNA-binding zinc finger repeats and is implicated in transduction of the SHH signal.  GLI2 is a putative oncogene in the development of human BCC.  The expression of GLI2 in skin results in activation of multiple SHH target genes.  (from OMIM 165230 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17424] "GST-pi is the anionic isozyme of glutathione S-transferase.  GST enzymes play an important role in detoxification by conjugating hydrophobic and electrophilic compounds with reduced glutathione.  GST-pi appears to be present in all tissues, with the exception of red blood cells, and is over expressed in multidrug-resistant cells.  GST-pi may be fatty acid ethyl ester synthase III, a heart enzyme that nonoxidatively metabolizes ethanol.  (from OMIM 134660 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17425] "Multiple exostoses type 1 gene product, one of three EXT genetic loci involved in hereditary multiple exostoses.  EXT1 protein is a transmembrane glycoprotein glycosyltransferase involved in the biosynthesis of heparan sulfate, and a putative tumor suppressor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17426] "Menin is a product of the MEN1 tumor suppressor gene.  It regulates transcription through direct inhibition of the JUND transcription factor.  Menin interacts with SMAD3 and appears to be required for SMAD3/4-DNA binding at transcriptional regulatory sites.  (from OMIM 131100 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17427] "ESX, a novel member of the ETS transcription factor family, is a tumor marker exclusively expressed in epithelial cells.  ESX contains two putative DNA-binding domains: an ETS domain and an A/T hook domain.  (from OMIM 602191 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17428] "A surface receptor on NK cells involved in binding to MHC Class I molecules presented on somatic cells as part of a recognition mechanism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17429] "NOTCH4 Protein is a Drosophila Notch receptor homologue with 29 extracellular EGF-like repeats, three Notch/lin-12 repeats, a transmembrane region, six intracellular cdc10/ankyrin repeats, a polyglutamine domain, and a C-terminal PEST region.  A component of an evolutionarily conserved intercellular signaling mechanism, NOTCH4 is expressed in a variety of tissues and appears to regulate cell fate decisions during embryonic vascular morphogenesis and remodeling.  NOTCH4 and NOTCH1 appear to have partially overlapping roles during embryogenesis in mice.  MMTV INT3 interruption of NOTCH4 produces a gain-of-function truncated product, containing only the transmembrane and intracellular domains, that has profound consequences for mammary gland development and tumorigenesis.  (from OMIM 164951 and NCI)"                                                                                                                                                            
[17430] "Involved in DNA damage-inducible cell cycle arrest, CHES1, a forkhead transcription factor family member, activates a MEC1-independent checkpoint pathway.  (from OMIM 602628 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17431] "Encoded by Human ANGPT2 Gene, Angiopoietin 2 is a 496-amino acid 57 kD (precursor) homodimeric secreted protein that contains a fibrinogen-like C-terminus.  ANG2 is nearly 60% identical to ANG1.  A 61 kD homodimeric alternative ANG2(443) product lacks 53 amino acids found in ANG2 encoded by exon B and part of the N-terminal coiled-coil domain.  Like ANG2 and ANG1, secreted ANG2(443) binds endothelial TIE2 receptor tyrosine kinase, but not TIE1.  ANG2(443) partially inhibits ANG2 and ANG1 binding to TIE2.  As an ANG1 and TIE2 antagonist, ANG2 may counteract blood vessel maturation or stability by loosening cell-matrix contacts and inducing endothelial apoptosis.  With VEGF, ANG2 may facilitate endothelial cell migration and proliferation.  In adults, ANGPT2 is only expressed at the sites of vascular remodeling.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                 
[17432] "Studies to identify or characterize the mechanism of action of non-infectious exogenous agents, conditions, or procedures that initiate, promote, or otherwise contribute to the development of cancer. Although infectious agents are excluded from this definition, extrinsic factors that increase exposure to these agents (e.g., occupation, sexual activity, needle sharing, transfusion) are considered environmental. Examples of other factors included are atmospheric pollution; occupational or medical exposure to radiation or chemicals; dietary components or contaminants; tobacco use; radon contamination of air or drinking water; exposure to electromagnetic fields; surgical procedures; heat, cold, trauma, or other types of physiological or psychological stress."                                                                                                                                                                                                       
[17433] "A decrease in the size of a tumor, or in the extent of cancer in the body, in response to treatment. Also called partial response."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17434] "Use of tobacco in any form i.e. smoking, chewing or sniffing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17435] "Alterations in DNA that occur after conception. Somatic mutations can occur in any of the cells of the body except the germ cells (sperm and egg) and therefore are not passed on to children. These alterations can (but do not always) cause cancer or other diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17436] "Multiplication or reproduction by cell division of immature precursor cells that have not achieved a fully differentiated state. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17437] "Human antibodies which recognize mouse antibodies.  These often develop in response to treatment with antibodies and limit the effectiveness of the treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17438] "Gy.  a radiation dose unit"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17439] "The special unit for radiation absorbed dose, which is the amount of energy from any type of ionizing radiation (e.g., alpha, beta, gamma, neutrons, etc.) deposited in any medium (e.g., water, tissue, air). A dose of one rad means the absorption of 100 ergs (a small but measurable amount of energy) per gram of absorbing tissue (100 rad = 1 gray). (NRC)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17440] "A nurse who specializes in treating and caring for people who have cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17441] "A large self-serving retail or wholesale market that sells food and household goods. (WEBS84)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17442] "The older and more populated and (usually) poorer central section of a city."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17443] "A unit of measurement of the dose of radiation received or absorbed, recorded in Grays (Gy) or Rads"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17444] "A building for public worship or religious services. (WEBS84)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17445] "RAEB: Electrically neutral elementary particles found in all atomic nuclei except light hydrogen; the mass is equal to that of the proton and electron combined and they are unstable when isolated from the nucleus, undergoing beta decay. Slow, thermal, epithermal, and fast neutrons refer to the energy levels with which the neutrons are ejected from heavier nuclei during their decay. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17446] "A doctor who removes or repairs a part of the body by operating on the patient."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17447] "Encoded by Enzyme Inhibitor Genes, Enzyme Inhibitor Proteins block or suppress the catalytic activity of enzymes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17448] "Proteins whose major function is to give shape and support to tissues, cells, and subcellular structures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17449] "To teach theory and hands on experience"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17450] "application of bioengineering and biomimetic principles for the restoration, repair, replacement, and assembly of functional tissues and organs; application of engineering and life sciences in development of artificial tissues or organs using living cells and different types of biomaterial matrices such as hydrogel, 3 dimentional mesh scaffolds or biodegradable polymers; engineered tissues can restore, maintain, or improve tissue function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17451] "Bioengineering integrates physical, chemical, or mathematical sciences and engineering principles for the study of biology, medicine, behavior, or health. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17452] "The probability that exposure to some agent or substance will adversely transform cells to replicate and form a malignant tumor. (EPA Terminology Reference System)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17453] "The process by which normal cells are transformed into cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17454] "Cardiovascular Pharmacology; the study of the effects of drugs upon the heart or circulatory system"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17455] "Cell growth regulation controls the rate, or the mechanism, of complex coordinated cellular phenomena that promote cell metabolism, cell growth, and cell division."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17456] "An increase in the number of cells as a result of cell growth and cell division."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17457] "The study of the cellular changes associated with the development of neoplastic conditions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17458] "Any studies of cancer caused by chemicals; chemicals as related to the carcinogenesis process."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17459] "Comparative genomic hybridization (CGH) is a technique that allows the detection of losses and gains in DNA copy number across the entire genome without prior knowledge of specific chromosomal abnormalities.  Comparative genomic hybridization utilizes the hybridization of differentially labeled tumor and reference DNA to generate a map of DNA copy number changes in tumor genomes. Comparative genomic hybridization is an ideal tool for analyzing chromosomal imbalances in archived tumor material and for examining possible correlations between these findings and tumor phenotypes. (from Ried et al. J Mol Med 1997 75:801-14)"                                                                                                                                                                                                                                                                                                                                                 
[17460] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17461] "branch of genetics primarily concerned with how genes control or regulate differentiation and growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17462] "study of the development of the brain and nervous system; does not include the psychological or behavioral aspects or nervous system repair; applies to any age group when the nervous system is undergoing development."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17463] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17464] "Nuclear, DNA binding protein; regulates transcription; product of the c-fos proto-oncogene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17465] "Gel electrophoresis is a method of separating large molecules (such as DNA fragments or proteins) from a mixture of similar molecules by electrophoretic filtration through a gelatinous matrix.  Subject to an electric field, each molecule in the sample mixture migrates through the matrix at a different rate, depending mainly on electrical charge and size, resulting in spatial separation within the matrix of each molecular species in the sample mixture.  Agarose and acrylamide in a cylindrical tube or slab gel are commonly used media for electrophoresis of proteins and nucleic acids."                                                                                                                                                                                                                                                                                                                                                                                       
[17466] "General term referring to the interaction of genetic factors and environmental influences."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17467] "A gene mutation is an alteration in the nucleotide sequence of a gene, involving a single or multiple nucleotide substitution, deletion, insertion, or rearrangement that is perpetuated in subsequent divisions of the cell in which it occurs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17468] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17469] "Physiologic control of immune function.  Includes all levels of regulation from gene expression mechanisms, through cell-cell interactions, to organism-wide responses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17470] "cell line derived from a pleural effusion of a human breast adenocarcinoma; has retained several characteristics of differentiated mammary epithelium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17471] "The science of simulating the motions of a system of particles. (Karplus and Petsko)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17472] "Description of disease and disease processes based upon the underlying protein and genetic defects rather than by a description of morphology."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17473] "biochemical correlates of learning, memory, and other psychological processes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17474] "Embryonic formation of muscle cells or fibers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17475] "The term special populations refers to those population segments that may experience, or are known to experience, high cancer rates and/or are underserved in terms of cancer prevention and control programs.  Special populations include geographically isolated and other medically underserved populations, blue-collar groups, the elderly, lower-income groups, Alaskan natives, American Indians, Hispanics, Asian- Americans, Blacks, native Hawaiians, and American Samoans."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17476] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17477] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17478] "Specific degradation of a protein - involving conjugation, transport, oxidation, and proteolysis - involved in signal transduction or cell communication events; not to be confuse with proteolysis, which applies only to peptide bond hydrolysis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17479] "Proteolysis typically involves hydrolysis of specific peptide bond(s) with formation of smaller polypeptides in a target protein during maturation or modification of functional activity. The process may be catalyzed by proteolytic enzymes, by acids, or by bases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17480] "A molecule inside or on the surface of a cell that binds to a specific substance and causes a specific physiologic effect in the cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17481] "pathway for taking up substances which first bind to specific cell surface receptors in coated pits and are then internalized by endocytosis; also internalizes obsolete cell surface receptors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17482] "family of soluble, cytoplasmic carrier proteins which bind their lipoid signal ligands at the cell membrane and transport them to the nucleus, where the complex binds to DNA and affects transcription of specific proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17483] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17484] "quantitative relationship between reactants and products in a chemical reaction due to conservation of the total number of atoms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17485] "RAEB:Three-dimensional configuration of biological molecules and influence of structure on function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17486] "Mechanisms whereby proteins are sorted or directed to their proper location in the cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17487] "three-dimensional image reconstruction technique whereby an aqueous suspension of a sample is applied in an extremely thin film to a grid, frozen in liquid nitrogen, maintained in this state by means of a special mount, and then observed in the electron microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17488] "PCR-based method for isolating unique sequences; also, used for comparing differences between two complex genomes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17489] "A mitochondrial membrane protein, BCL-2 protein is responsible for blocking apoptosis in normal cells.  Growth factor-stimulated phosphorylation by PKC promotes anti-apoptotic activity of BCL-2 during G2/M.  BCL-2 regulates cell death by controlling mitochondrial membrane permeability.  Cleavage by caspases during apoptosis yields a pro-apoptotic BCL-2 product that causes release of cytochrome C into the cytosol, promoting further caspase activity.  Over expression from translocation t(14;18) of BCL-2 with the immunoglobulin gene region is involved in B-cell lymphomas.  (from OMIM 151430 and NCI)"                                                                                                                                                                                                                                                                                                                                                                        
[17490] "A protein which binds to an enhancer.  Typically, it binds to a cis enhancer element and modifies the transcriptional activity of the associated gene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17491] "Alteration in light reflectance as a result of binding of molecules to a surface from which total internal reflection is occurring. (on-line medical dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17492] "The buildings and equipment used for research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17493] "The science concerned with phenomena that involve biology, physics, and chemistry principles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17494] "A gene on chromosome 13 that normally helps to suppress cell growth.  A person who inherits an altered version of the BRCA2 gene has a higher risk of getting breast, ovarian, or prostate cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17495] "The origin or production, or development of cancer, including carcinomas and other malignant neoplasms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17496] "The study of rates and mechanisms of chemical reactions and of the factors on which they depend."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17497] "RAEB: Effects of low temperatures on living organisms or their components."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17498] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17499] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17500] "Lipophilicity represents the affinity of a molecule or a moiety for a lipophilic environment. It is commonly measured by its distribution behavior in a biphasic system, either liquid-liquid or solid-liquid, or thin-layer chromatography system. (from Pure Appl. Chem., 70, 1129-1143 (1998))"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17501] "RNA transport is the translocation of RNA molecules from one cellular location to another, such as transport from the nucleus to the cytoplasm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17502] "The induction or development of leukemia. (Dorland's Illustrated Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17503] "The first stage of tumor induction by a carcinogen; subtle alteration of cells by exposure to a carcinogenic agent so that they are likely to form a tumor upon subsequent exposure to a promoting agent. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17504] "Medical devices which interact with or replace parts of the nervous system, eg cochlear implant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17505] "A subdiscipline of immunology with a focus on the nervous system and its interactions with the immune system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17506] "Model for high performance computing in which a problem is solved by multiple processors working cooperatively and simultaneously."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17507] "A mutation in which a base change results in substitution of one amino acid for another.  This change may result in alteration of the protein's activity or stability."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17508] "A point mutation involving substitution of one base-pair for another, i.e., replacement of one purine for another purine or of one pyrimidine for another pyrimidine without change in the purine-pyrimidine orientation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17509] "A point mutation involving base substitution in which the orientation of purine and pyrimidine is reversed, in contradistinction to transition mutation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17510] "RT-PCR is short for reverse transcriptase-polymerase chain reaction. It is a technique in which an RNA strand is first transcribed into a DNA complement and then subjected to PCR amplification. Transcribing an RNA strand into a DNA complement is termed reverse transcription and is done by the enzyme reverse transcriptase. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17511] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17512] "Any compound that has been joined with a radioactive substance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17513] "Human ERG Gene (ETS Family) at 21q22.3 encodes a FLI1-related transcription factor.  ERG1 and ERG2 proteins derive from alternative splicing, polyadenylation, and translation initiation.  ERG2 is a sequence-specific purine-rich DNA-binding phosphoprotein expressed at higher levels in early myeloid cells than in mature lymphoid cells.  It regulates genes required for maintenance or differentiation of early hematopoietic cells.  Many Ewing sarcoma cases display t(21;22) chromosomal translocation involving ERG and EWSR1, resulting in a hybrid protein containing the DNA binding domain of ERG.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                              
[17514] "Molecular biology technique used to identify interacting proteins in a yeast model.  A protein of interest (the bait) is fused to the DNA-binding domain of a yeast transcription factor (usually GAL4).  (Usually) a cDNA library is fused to the GAL4 activation domain.  The library is then introduced into yeast cells carrying the bait construct.  Functional interaction of the bait with fusion proteins from the library bring together the binding and activation domains of the transcription factor, allowing activation of a reporter gene. (syn: yeast two-hybrid system) (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                                                 
[17515] "The study of the structure and dynamics of computational systems using mathematical, logical, and empirical tools."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17516] "Mass spectrometers coupled in series.  The targeted compound is selectively ionized, and its characteristic ions are separated from others in the mixture in the first mass spectrometer. The selected primary ions are then decomposed by collision, and from the resulting products the final mass analyzer selects secondary ions characteristic of the targeted compound. Tandem mass spectrometry can achieve specificities and sensitivities equivalent of those of methods such as radioimmunoassay and gas chromatography/mass spectrometry, while performing analyses in much shorter times. (McLafferty, 1981.  Science 214:280-7)"                                                                                                                                                                                                                                                                                                                                                       
[17517] "Refers to the targeted disruption of a gene within its normal biological context.  Utilized to examine the involvement of a gene in a complex biological process."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17518] "Exchange of like DNA sequences on homologous chromosomes by recombination."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17519] "An occupational discipline which unites information science with computer science.  It is concerned with the development of techniques for the collection and manipulation of data, and the use of such data."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17520] "Any subcellular or molecular event, process, or condition involved in translocation of a biological macromolecule from one site or compartment to another, entirely within a cell. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17521] "The process whereby cellular proteins are positioned and sequestered in the correct cellular compartment for proper function.  The process of moving proteins from one cellular compartment to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17522] "Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17523] "Refers to a class of evolving technologies that provide leading-edge computational capabilities.  Includes scalable high performance computers, high end graphic systems, and high speed networks.  Used for molecular modeling, genome analysis, and image processing, among others. (from http://www.mhpcc.edu/)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17524] "electrophoretic technique for estimating molecular weights of polypeptides by reducing all disulfide bonds, saturating with the anionic detergent sodium dodecylsulfate (SDS), and electrophoresing on polyacrylamide gels."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17525] "Passage of light through body tissues or cavities for examination of internal structures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17526] "Class of enzymes that phosphorylate protein substrates at tyrosine or threonine residues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17527] "Caspases are a family of intracellular cysteine proteinases involved in inflammation and apoptosis.  These enzymes appear to be involved in the initial signaling events, as well as the downstream proteolytic cleavages, that result in apoptotic cell death.  They are specific for aspartic acid at the P1 position and are divided into two classes based on the lengths of their N-terminal pro-domains.  Caspases-1, -2, -4, -5, -8, and -10 have long pro-domains; caspases-3, -6, -7, and -9 have short pro-domains.  (from Science 1998. 281:1312 and Br Med Bull 1997. 53:478)"                                                                                                                                                                                                                                                                                                                                                                                                          
[17528] "Refers to the hybridization of fluorescently labeled, chromosome-specific, composite probe pools to cytological preparations. It allows the visualization of individual chromosomes in metaphase or interphase cells and the identification of both numerical and structural chromosomal aberrations with high sensitivity and specificity.  Chromosome painting can be applied to cross-species comparisons as well as to the study of chromosomal rearrangements. The simultaneous hybridization of multiple chromosome painting probes, each tagged with a specific fluorochrome or fluorochrome combination, has resulted in the differential color display of chromosomes, i.e. spectral or color karyotyping. (From Ried  et al 1998 Hum Mol Genet 7:1619)"                                                                                                                                                                                                                                   
[17529] "Expressed Sequence Tags (ESTs) are essentially Sequence Tagged Sites (EST) that are represented in mRNA.  They are derived as 300-500 bp single-pass mRNA sequence reads from many of the genes expressed in a given tissue and/or at a given developmental stage. They represent a snapshot of gene expression in a given place or time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17530] "an advantageous side-effect of a graft-vs-host reaction in which a leukemia patient is first irradiated to kill residual leukemic cells and is then given a bone marrow graft to replenish the immune system.  If cytotoxic T cells are not depleted from the bone marrow graft, these alloreactive T cells can attack the host's cells (graft-vs-host reaction) but can also attack the host's residual leukemic cells, thereby assisting in preventing recurrence of disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17531] "Refers to the process by which students and teachers at different sites carry out learning and instruction via cable connection, conventional phone lines, or computer networks."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17532] "A DNA chip is an orderly array of DNA samples afixed to a support.  Using robots thousands of samples can be arrayed on a single chip.  The chip is used in various types of hybridization experiments."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17533] "The collection, writing, and editing of material of current interest for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17534] "Unpublished or draft copies of scientific articles and book chapters"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17535] "EIF2B is a heteropentameric complex (alpha, beta, gamma, delta, and epsilon subunits) essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate (restores GTP bound EIF2). For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. Thus, EIF2B sustains translation. EIF2B-epsilon contains a putative nucleotide-binding domain that may be involved in nucleotide exchange.  EIF2B defects cause VWM. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17536] "Glandular Kallikrein 2 isoforms 1 (261-aa, 28.7-kD prepropeptide), 2 (PGK-10A, 222-aa), 3 (164-aa) are encoded by human KLK2 Gene (Kallikrein Family). The mature serine protease is 237 amino acids. Glandular kallikreins comprise specific proteases involved in processing active peptides. KLK2 exhibits 66% and 73% homology with KLK1 and APS. Glandular kallikreins release vasoactive peptides from kininogen; the kininogenase activity of different kallikreins is highly variable. Kallikrein 2 cleaves kininogen Met-X, Arg-X, or Leu-X bonds to release lys-bradykinin (kallidin) involved in vasodilation and smooth muscle contraction. The physiologic role of specific kallikreins is often unrelated to the kininogenase activity. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                  
[17537] "A member of a group of enzymes that can break down proteins, such as collagen, that are normally found in the spaces between cells in tissues (i.e., extracellular matrix proteins).  Because these enzymes need zinc or calcium atoms to work properly, they are called metalloproteinases.  Matrix metalloproteinases are involved in wound healing, angiogenesis, and tumor cell metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17538] "Neuregulin-1 was first cloned as \"heregulin\" and \"neu differentiation factor\" and was initially thought to be a ligand for ErbB2, which is overexpressed in about 25% of women with breast cancer. Neuregulin-1 has also been studied as the \"glial growth factor,\" which acts as a Schwann cell mitogen, and as \"ARIA\" (acetylcholine receptor inducing activity), a regulator of the expression of acetylcholine receptors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17539] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17540] "A possible transcriptional activating factor, BCL3 is activated by phosphorylation and functions as an IKB specific for the p50 subunit of NFKB, inhibiting its translocation to the nucleus.  BCL3 confers a survival advantage to T-cells, possibly by promoting the expression of genes repressed by NFKB members.  Translocation t(14;19)(q32;q13.1), involving BCL3 and immunoglobulin gene regions, is associated with B-CLL.  (from OMIM 109560 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17541] "A member of the \"ID\" subfamily, ID2 promotes cell cycle progression by inhibiting RB, p107, and p130.  By increasing ID2 expression, MYC overrides RB suppression of ID2 action.  Since ID2 lacks a DNA-binding domain it must work through dimerization with other HLH transcription factors.  (from SWISS-PROT Q02363, OMIM 600386, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17542] "Related to B cell activation, PTK72 is a tyrosine kinase that becomes tyrosine phosphorylated and activated soon after anti-Ig stimulation of B cells.  It is found associated with the mIg receptor complex.  Unlike the membrane-bound Src-family tyrosine kinases, PTK72 is primarily present as a soluble cytosolic protein.  It is probably the product of the syk gene and is highly related to the ZAP-70 protein associated with T cell activation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17543] "MAF Protein contains a leucine zipper motif similar to that in many bZIP DNA binding proteins, including FOS, JUN, and MYC oncogenes.  Members of the MAF family appear to play important roles in the regulation of differentiation.  (from OMIM 177075 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17544] "The GLI1 Protein, a Kruppel family protein, is homologous to Drosophila Cubitus interruptus and contains five DNA-binding zinc finger repeats, implicated in transduction of the SHH signal; an endodermal signal that controls hindgut patterning and lung growth.  The GLI1 gene is found amplified in a malignant glioma.  (from OMIM 165220 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17545] "NCOA3 is a nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in hormone-dependent fashion. NCOA3 recruits 2 other nuclear factors, CBP and PCAF, and thus plays a central role in creating a multisubunit coactivator complex. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17546] "This gene at 5p15.33 consists of 16 exons and 15 introns, and encodes TERT that mediates reverse transcriptase-like catalysis and is limiting for telomerase function in telomere maintenance. TERT also delays cell cycle exit in cardiac muscle, induces hypertrophy in postmitotic cells, and promotes cardiac myocyte survival. The TERT promoter is GC-rich, lacks TATA and CAAT boxes, but contains binding sites for MYC oncoprotein and other transcription factors that may be involved in its regulation. The TERT promoter is inactive in normal and in transformed pre-immortal cells but is activated with cell immortalization. This gene is expressed at high levels in primary tumors, cancer cell lines, and telomerase-positive tissues, but is undetectable in telomerase-negative cell lines and differentiated telomerase-negative tissues. Telomerase activity is an independent prognostic factor in neuroblastoma."                                                         
[17547] "A member of the TNF family.  TRAIL Receptor 1 (DR4) contains two cysteine-rich pseudorepeats resembling regions in TNFR1, DR3, and FAS, a transmembrane domain, and an intracellular death domain.  Unlike FAS, TNFR1, and DR3, DR4 does not use FADD to transmit the death signal, suggesting the use of a distinct signaling machinery.  (from OMIM 603611 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17548] "Encoded by human NRG2 Gene (NRG Family), variant type I membrane or soluble growth factor Neuregulin 2 proteins (422-858-aa, 91.7-kD precursor) contain an N-terminal domain, an Ig-C2 loop, an EGF-like domain, a transmembrane sequence, and a large cytoplasmic tail with potential N-linked and O-linked glycosylation sites. The membrane-bound form seems to be inactive and the cytoplasmic domain may regulate trafficking and proteolytic processing (by dimerization). Like Neuregulin 1, Neuregulin 2 binds to transmembrane ERBB3 and ERBB4 tyrosine kinase receptors, recruits ERBB1 and ERBB2 coreceptors, and induces receptor activation. ERBB receptor binding may involve entirely the EGF-like domain. Found primarily in the nervous system, Neuregulin 2 induces growth and differentiation of epithelial, neuronal, glial, and other cell types. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                 
[17549] "A product of the tumor suppressor gene TSC1.  Hamartin and tuberin (TSC2) associate physically and may function together in the insulin-signaling pathway.  Hamartin may stabilize ubiquitinated tuberin, which contributes to inhibition of cell growth.  Loss of hamartin leads to loss of cell adhesion and initiates the development of TSC hamartomas.  (from OMIM 605284 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17550] "Product of the Axin1 Gene.  Triggers degradation of beta-catenin and helps establish dorsal-ventral patterning during embryogenesis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17551] "Receptor for Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17552] "Survivin is an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. It is abundantly expressed in various human cancers but undetectable in normal differentiated tissues. Survivin associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. It is physically associated with cyclin-dependent kinase p34(cdc2) on the mitotic apparatus, and is phosphorylated on Thr(34) by p34(cdc2)-cyclin B1 in vitro and in vivo. Therefore, survivin phosphorylation on Thr(34) may be required to preserve cell viability at cell division. Manipulation of this pathway may facilitate the elimination of cancer cells at mitosis. (from LocusLink)"                                                                                                                                                                                                                                                                
[17553] "Encoded by human NRG3 Gene (NRG Family), conserved 720-aa Neuregulin 3 is a brain and testis soluble growth and differentiation factor, and a type I membrane protein containing 2 hydrophobic segments similar to the transmembrane domain and internal signal sequence in NRG1. NRG3 also contains an N-Ala/Gly-rich segment, an EGF motif, and a mucin-like Ser/Thr-rich region with sites for O-linked glycosylation. Membrane-bound NRG3 may be inactive. Preceded by extensive glycosylation, external proteolytic cleavage close to the plasma membrane may involve dimerization of the intracellular domain. A ligand for ERBB4 receptor tyrosine kinase (likely via the EGF-like domain), NRG3 does not bind to ERBB2, ERBB3, or EGF receptor. The ERBB4 binding sites of NRG1 and NRG3 may overlap. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                          
[17554] "PTEN contains a tyrosine phosphatase domain and a region of homology to auxilin and tensin (which interacts with actin).  PTEN inhibits insulin-induced IRS1 phosphorylation and IRS1/GRB2/SOS complex formation and influences the PI3 kinase/AKT pathway in FAS-induced apoptosis.  PTEN blocks cell cycle progression in G1 through negative regulation of PI3 kinase/AKT signaling to cyclin-dependent kinase inhibitor p27(KIP1), increasing p27, decreasing cyclin D1, and inhibiting AKT phosphorylation.  PTEN may regulate cell interactions with the extracellular matrix and effect cell migration, integrin-mediated cell spreading, and formation of focal adhesions.  PTEN reduces tyrosine phosphorylation of FAK.  The PTEN gene is transactivated by p53.  (from OMIM 601728 and NCI)"                                                                                                                                                                                             
[17555] "A member of the ICE cysteine-protease family.  A downstream factor in apoptosis induced by TNFR and FAS"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17556] "LKB1, a serine/threonine kinase, is thought to act in the VEGF signaling pathway.  LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways.  LKB1 protein translocates to mitochondria during apoptosis.  (from OMIM 602216 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17557] "Histone acetylation, particularly of histone H4, has been proposed to play an important role in replication-dependent nucleosome assembly. The HAT1 protein contains D, A, and B motifs, which are present in many N-acetyltransferases, including those that acetylate substrates other than histones. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46 (RBBP7). The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. (from LocusLink)"                                                                                                                                                                                                                                                                   
[17558] "Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP; MIM 600075) and TBP-associated factors, or TAFs (e.g., TAF2B; MIM 604912), in 2 distinct complexes, TFIID and B-TFIID. The TFIID complex is composed of TBP and more than 8 TAFs. However, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170, also called TAF172, and has DNA-dependent ATPase activity.(LocusLink, as supplied by OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17559] "The MET proto-oncogene encodes hepatocyte growth factor receptor, a cell surface receptor-like tyrosine kinase comprised of disulfide-linked 50 kD (alpha) and 145 kD (beta) subunits.  In the fully processed c-MET product, the alpha subunit is extracellular, and the beta subunit has extracellular, transmembrane, and tyrosine kinase domains, as well as sites of tyrosine phosphorylation.  The beta subunit of the c-MET proto-oncogene product is the cell surface receptor for hepatocyte growth factor.  c-MET is related to the insulin receptor and ABL oncogene.  (from OMIM 164860 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                       
[17560] "A putative RNA helicase"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17561] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17562] "RAEB: The medical science, and specialty practice, concerned with all aspects of disease, but with special reference to the essential nature, causes, and development of abnormal conditions, as well as the structural and functional changes that result from the disease processes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17563] "The microscopic study of characteristic tissue abnormalities by employing various cytochemical and immunocytochemical stains.  -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17564] "Data processing largely performed by automatic means. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17565] "An operation that restores or improves the appearance of body structures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17566] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17568] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17569] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17570] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17571] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17572] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17573] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17574] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17575] "A specimen obtained by biopsy, which is a process of removing tissue from living patients for diagnostic examination."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17576] "A brief, simple, and easy to use tool for the assessment of pain in both clinical and research settings. The BPI uses simple numeric rating scales from 0 to10 that are easy to understand and easy to translate into other languages. On the BPI, mild pain is defined as a worst pain score of 1 - 4, moderate pain is defined as a worst pain score of 5 - 6, and severe pain is defined as a worst pain score of 7-10."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17577] "A bandage designed to provide pressure to a particular area."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17578] "A group of physicians, hospitals, or both formed to treat a large number of persons in the same way so that a new treatment can be evaluated quickly. Clinical trials of new cancer treatments often require many more people than a single physician or hospital can care for."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17579] "Refers to cancer that has spread from the original (primary) tumor to distant organs or distant lymph nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17580] "A drug preparation that contains the active drug in very tiny fat particles. This fat-encapsulated drug is absorbed better, and its distribution to the tumor site is improved."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17581] "The flow of lymph from an area of tissue into a particular lymph node."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17582] "The use of dyes and radioactive substances to identify lymph nodes that contain tumor cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17583] "An excess of a particular protein on the surface of a cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17584] "A decrease in the size of a tumor, or in the extent of cancer in the body, in response to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17585] "Cancer that is neither decreasing nor increasing in extent or severity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17586] "A staging system for prostate cancer that uses ABCD.  ?A? and ?B? refer to cancer that is confined to the prostate. ?C? refers to cancer that has grown out of the prostate but has not spread to lymph nodes or other places in the body. ?D? refers to cancer that has spread to lymph nodes or to other places in the body. Also called the ABCD rating or the Jewett staging system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17587] "A laboratory test to analyze the responsiveness of a tumor to a specific drug."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17588] "Electron microscopy in which the electron beam passes through the sample."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17589] "Stored energy.  In biological systems energy is stored in the structure of molecules and is released through metabolism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17590] "\"A thermodynamic term used to describe the energy that may be extracted from a system at constant temperature and pressure. In biological systems the most important relationship is: _G = RTln(Keq), where Keq is an equilibrium constant.  \""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17591] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17592] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17593] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17594] "The science concerned with drugs together with the science concerned with the detection, chemical composition, and pharmacologic action of toxic substances or poisons and the treatment and prevention of toxic manifestations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17595] "The difference between the concentration at which clinical benefit (cancer cell killing) is seen and that at which toxicity to normal tissues occurs.  The larger the therapeutic index the safer a drug is."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17596] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17597] "An environmentally produced phenotype simulating the effect of a particular genotype."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17598] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17599] "Public communication via television, radio, newspapers, pamphlets, telephone, and other media to influence health or social behaviors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17600] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17601] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17602] "Social Group; people sharing some social relationship."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17603] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17604] "Glossary; an alphabetical list of technical terms in some specialized field of knowledge; usually published as an appendix to a text on that field."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17605] "A formal statement that describes and gives notice to the grantee community of the existence of an NIH-wide or individual Institute/Center extramural research activity/interest or announces the initiation of a new or modified activity/interest or mechanism of support and invites applications for grant or cooperative agreement support. (from The NCI Grants Process: Glossary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17607] "There are two main goals of time series analysis: (a) identifying the nature of the phenomenon represented by the sequence of observations, and (b) forecasting (predicting future values of the time series variable). (from http://www.statsoftinc.com/textbook/sttimser.html)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17608] "The concept of ethnic origin is an attempt to classify people, not according to their current ethnicity, but according to where their ancestors came from.  Ethnic origin has become a popular classification in statistics, where the concept of race has been largely discarded. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17609] "The indigenous people of Alaska and their descendants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17610] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17611] "Cell surface receptors that are coupled to G-proteins (GTP-binding protein).  G-protein coupled receptors are thought to have seven membrane spanning domains and have been divided into 2 subclasses: those in which the binding site is in the extracellular domain for example receptors for glycoprotein hormones, such as thyroid stimulating hormone (TSH) and follicle-stimulating hormone (FSH) and those in which the ligand binding site is likely to be in the plane of the 7 transmembrane domains for example rhodopsin and receptors for small neurotransmitters and hormones for example muscarinic acetylcholine receptor. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                            
[17612] "College, University or institute with scholastic life or environment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17613] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17614] "A process used for separating mixtures by virtue of differences in absorbency.  It involves stationary and mobile phases.  The stationary phase was packed in a column with materials that can be of any partitioning capability, adsorption, ion exchange, or affinity.  The mobile phase (either liquid or gas) is the mixture that required to be separated."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17615] "A decrease in the size of a tumor or in the extent of cancer in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17616] "Health hazards at home, in the work place, or in nature, i.e.,  infectious agents, irritants, respiratory fibrotic agents, asphyxiants, allergens, metabolic poisons, physical agents, mutagens, teratogens, and carcinogens. (Winett et al: Health Psychology and Public Health)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17617] "Document type"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17618] "A decrease in or disappearance of signs and symptoms of cancer.  In partial remission, some, but not all, signs and symptoms of cancer have disappeared.  In complete remission, all signs and symptoms of cancer have disappeared, although there still may be cancer in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17619] "Cancer Genetics; the science of heredity and the biological process of transmission of characteristics from progenitor to offspring, especially concerning a heritable predisposition to cancer susceptibility."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17620] "The MET oncogene is derived from a chromosomal rearrangement involving the MET and TPR (translocated promoter region) loci and is a cloned gene for Hereditary Papillary Renal Carcinoma.  The MET proto-oncogene encodes hepatocyte growth factor receptor, a disulfide-linked two subunit receptor protein tyrosine kinase.  The human gene is located at 7q31."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17621] "A cloned gene for Familial Gastric Cancer, human CDH1 Gene (CDH Family) at 16q22.1 encodes E-Cadherin, the main epithelia (non-neural) homodimeric Ca2+-dependent homophilic cell-cell adhesion glycoprotein. Similar to other cadherins, CDH1 has sixteen exons spanning 100 kb. An invasion suppressor type I membrane protein ligand for integrin Alpha-E/Beta-7, E-cadherin is comprised of five extracellular Ig-like cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. The ectodomain mediates bacterial adhesion to mammalian cells; the cytoplasmic domain is required for internalization. As a major event in cancer proliferation, invasion, and metastasis due to dysfunction of cell-cell adhesion, E-cadherin down regulation correlates with invasive potential and poor carcinoma prognosis. (from LocusLink 999, SWISS-PROT P12830, OMIM 192090, and NCI)"                                                                                               
[17622] "Human CDK4 Gene (CDC2/CDKX Family) at 12q14, a cloned gene for Hereditary Melanoma, encodes Cyclin Dependent Kinase 4, a serine/threonine protein kinase involved in control of cell proliferation during G1.  CDK4 forms complexes with D-type cyclins and blocks RB repression of transcription in early G1.  CDC37 and HSP90 enhance CDK4 stability.  Cyclin-dependent kinase inhibitor-2 (p16) inhibits CDK4. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17623] "A cloned gene for Hereditary Multiple Exostoses, the widely expressed 350 kb human EXT1 Gene (EXT Family) at 8q24.11-q24.13 is composed of eleven exons that encode the tumor suppressor exostosin-1 protein.  A type II transmembrane glycoprotein, EXT1 with exostosin-2 appears to form a Golgi-localized glycosyltransferase complex involved in cell surface heparan sulfate glycosaminoglycan synthesis.  EXT1 and EXT2 show striking similarity and may modulate the hedgehog signaling pathway.  The development of exostoses is mainly due to loss of EXT gene function.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                
[17624] "The 108 kb human EXT2 Gene (EXT Family) at 11p12-p11 encodes tumor suppressor exostosin-2 protein.  EXT2 maps to a 3 cM region containing polymorphic D11S903 and flanked by D11S1355 and D11S1361/D11S554.  A type II transmembrane glycoprotein, EXT2 with exostosin-1 appears to form a Golgi-localized glycosyltransferase complex involved in cell surface heparan sulfate glycosaminoglycan synthesis.  EXT2 interacts with an UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase.  EXT1 and EXT2 show striking similarity and may modulate the hedgehog signaling pathway.  The development of exostoses is due mainly to loss of function of EXT genes.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                           
[17625] "A cloned gene for Peutz-Jeghers Syndrome and 190 kb proximal to D19S886, human LKB1/STK11 Gene (SER/THR family) at 19p13.3 is associated with gastrointestinal tumors, as well as breast and other cancers.  Composed of nine exons transcribed telomere-to-centromere, STK11 extends over 23 kb.  Intron 2 splice junctions deviate from the GT/AG rule.  The mouse gene consists of ten exons over 15 kb.  LKB1, a serine/threonine kinase thought to act in the VEGF signaling pathway, associates with p53 and regulates p53-dependent apoptosis pathways.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                   
[17626] "Within an 8 cM region between D11S480 and D11S546, human MEN1 Gene at 11q13 is a cloned tumor suppressor gene for Multiple Endocrine Neoplasia, a predisposition for endocrine and carcinoid tumors.  The gene contains ten exons and expresses a ubiquitous 2.8 kb transcript that encodes MEN1 protein, which interacts with and inhibits JUND transcription factor.  Also interacting with SMAD3, menin appears to be required for DNA binding of SMAD3/4 at transcription regulatory sites.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17627] "The PTCH gene is a cloned gene for Basal Cell Nevus Syndrome, associated with skin cancer and childhood brain cancer.  The PTCH gene encodes the sonic hedgehog receptor, a protein with twelve transmembrane domains that represses transcription of genes encoding TGF beta and Wnt family signaling proteins.  PTCH is involved in embryonic development and adult cell growth control.  Sonic hedgehog binding to PTCH appears to activate the 7-transmembrane protein Smoothened by release from PTCH inhibition.  Basal cell carcinoma is associated with mutations that activate Smoothened or inactivate patched, causing excess activity of the hedgehog response pathway.  The human gene is located at 9q31."                                                                                                                                                                                                                                                                            
[17628] "The PTEN gene is a cloned gene for Cowden's Disease, associated with breast cancer and thyroid cancer.  PTEN contains a tyrosine phosphatase domain and a region of homology to auxilin and tensin (which interacts with actin).  PTEN inhibits insulin-induced IRS1 phosphorylation and IRS1/GRB2/SOS complex formation and influences the PI3 kinase/AKT pathway in FAS-induced apoptosis.  PTEN blocks cell cycle progression in G1 through negative regulation of PI3 kinase/AKT signaling to cyclin-dependent kinase inhibitor p27(KIP1), increasing p27, decreasing cyclin D1, and inhibiting AKT phosphorylation.  PTEN may regulate cell interactions with the extracellular matrix and effect cell migration, integrin-mediated cell spreading, and formation of focal adhesions.  PTEN reduces tyrosine phosphorylation of FAK.  The PTEN gene is transactivated by p53.  The human gene is located at 10q23.3."                                                                          
[17629] "The RET gene is a cloned gene for Hirschsprung's disease and Multiple Endocrine Neoplasia involving chromosomal rearragements; associated with pheochromocytoma, hyperparathyroidism, medullary thyroid cancer.  The RET gene, important for development, encodes a probable type I membrane protein receptor tyrosine kinase with an extracellular cadherin-like domain.  The human gene is located at 10q11.2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17630] "Between D18S1118 and D18S487, human MADH4 Gene (Dwarfin/SMAD family) at 18q21.1 contains eleven exons and is a cloned gene for Juvenile Polyposis and associated with colon cancer.  Critical for transmitting TGFB and related cytokine signals to the nucleus for target gene activation, the encoded SMAD4 tumor suppressor protein recognizes an eight base pair palindromic DNA regulatory sequence.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17631] "The TSC1 gene is a cloned gene for Tuberous Sclerosis 1 that encodes the protein hamartin, associated with renal cancer and brain tumor.  Hamartin and tuberin (TSC2), a putative GAP for RAP1 and RAB5, associate physically and may function together in the insulin signaling pathway.  Hamartin may stabilize ubiquitinated tuberin, which contributes to inhibition of cell growth.  Activated ezrin, radixin, and moesin (ERM proteins) promote linkage between integral membrane proteins and cytoskeleton proteins, such as F-actin.  Activation of ERM proteins requires a RHO cascade. Ezrin, radixin, moesin, and F-actin interact with hamartin.  Loss of hamartin leads to loss of cell adhesion and initiates the development of TSC hamartomas.  The human gene is located at 9q34."                                                                                                                                                                                                 
[17632] "The TSC2 gene is a cloned gene for Tuberous Sclerosis 2, associated with renal cancer and brain tumor, that appears to function as a tumor suppressor gene.  The product, tuberin, has a region of homology to the GTPase-activating protein GAP3 and stimulates RAP1A GTPase, but not RAP2, HRAS, RAC, or RHO activity.  Tuberin also exhibits GAP activity towards RAB5, a critical component of docking/fusion in the endocytic pathway.  Adaptor rabaptin-5 mediates tuberin association with RAB5.  Data suggest TSC1 and TSC2 may function together in the insulin signaling pathway.  Inactivating mutations of TSC2 cause enhanced growth and increased cell size with no change in ploidy.  The human gene is located at 16p13.3."                                                                                                                                                                                                                                                         
[17633] "The VHL gene at 3p25 encodes a tumor suppressor nuclear protein that functions via multi-protein complexes associated with transcriptional elongation and ubiquitination. VHL competes with elongin A for binding elongin B and C, and thereby inhibits transcription elongation. The hypoxia-inducible factor-1 (HIF1) alpha subunit binds to VHL and is targeted for destruction by an E3 ubiquitin ligase. HIF1 alpha is stabilized during hypoxia and VHL is present in the hypoxic HIF1 DNA-binding complex. VHL inhibits expression of hypoxia-inducing VEGF and GLUT1 genes. A VHL-responsive element binds transcription factor SP1. VHL binds and inhibits SP1. Accumulation of cyclin-dependent kinase inhibitor p27, due to enhanced protein stability, is VHL dependent and VHL may be involved in regulation of cell cycle exit. The VHL gene is associated with von Hippel-Lindau Syndrome that causes renal cancer, pheochromocytoma, and brain tumors."                             
[17634] "The WT1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context. WT1 is required for normal formation of the genitourinary system and mesothelial tissues. (OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17635] "The WT2 gene is a second Wilms tumor suppressor gene locus, at 11p13-p15.  Efforts to clone the WT2 gene(s) have not yet been successful."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17636] "The pathologic, physiologic, or biochemical mechanism resulting in the development of a disease or morbid process. Cf. etiology. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17637] "The return of signs and symptoms of cancer after a period of improvement."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17638] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17639] "Cathepsin B, encoded by the CTSB Gene, encodes a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of Cathepsin B has been associated with esophageal adenocarcinoma and other tumors. Tumors with overexpression of cathepsins have powerful potential for invasiveness in the early stage of gastric carcinoma. Gastric carcinoma cells that oversecrete cathepsins B have a high invasive and metastatic potential. At least five transcript variants encoding the same protein have been found for this gene. (From LocusLink, PMID 10931446 and NCI)"                                        
[17640] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17641] "The labor force available to do work on a project"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17642] "Inhaling smoke from tobacco in the form of a cigarette."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17643] "A glycoprotein catalase with a membrane-spanning domain and conserved positions of cysteine and histidine residues, TRP1 shares 40% amino acid sequence homology with mouse tyrosinase but has no tyrosinase activity and converts 5, 6-dihydroxyindole-2-carboxylic acid to melanochrome in premelanosomes.  TRP1 is identical to melanosomal protein, gp75.  (from OMIM 115501 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17644] "Maladaptive pattern of drug or alcohol use that may lead to social, occupational, psychological, or physical problems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17645] "Cardiovascular Pathology; a subdiscipline of pathology focusing on diseases of the heart or circulatory system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17646] "A quality of directional uniformity in material such that physical properties do not vary in different directions. In rocks, changes in physical properties in different directions, such as the alignment of mineral grains or the seismic velocity measured parallel or perpendicular to bedding surfaces, are forms of anisotropy. (from Oilfield glossary)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17647] "The branch of pathology that focuses the causes and nature and effects of diseases of the lungs and respiratory structures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17648] "In its most basic sense the term proteome refer to the total protein-encoding capability of an organism's genome.  In use it is also used to refer to the actual total expressed protein complement of an organism or to the identifiable proteins of a single tissue or cell type or subcellular compartment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17649] "A class of small GTP-binding regulatory proteins regulated by G protein coupled receptors that act as switches in signal transduction pathways.  The nature of the nucleotide bound to the protein determines its activity: GTP in the active state, GDP in the inactive state.  The prototype for this class of proteins is the cellular proto-oncogene RAS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17650] "Expressed as 2 alternative isoforms in platelets, human PDGFB Gene (PDGF/VEGF Family) encodes 241-aa 27-kDa (precursor) Platelet-Derived Growth Factor-Beta Chain, a potent mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released by platelets upon wounding to stimulate adjacent cell growth. PDGFB can exist as either antiparallel disulfide-linked homodimers or heterodimers with Platelet-Derived Growth Factor Alpha. A-A, B-B, and A-B, dimers can bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. PDGFB mutations are associated with meningioma. Reciprocal t(17;22)(q22;q13) translocations with COL1A1 result in unregulated growth factor expression and are associated with DFSP. (NCI)"                                                                                                                                                                  
[17651] "Variation of individual nucleotides, at a specific locus, between individuals.  These occur, on average, once every 1000 bases.  (A single nucleotide polymorphism may create a restriction fragment length polymorphism.)  They can be used in gene mapping and linkage analysis.  SYN SNP, Single Nucleotide Polymorphism"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17652] "Techniques for analysis of chromosomal and subchromosomal properties and structures, such as those to diagnose, classify, screen for, or manage genetic diseases and abnormalities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17653] "Heterotrimeric guanine nucleotide-binding proteins (G proteins) are signal transducers, attached to the cell surface plasma membrane, that connect receptors to effectors and thus to intracellular signaling pathways (1). Receptors that couple to G proteins communicate signals from a large number of hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. After the first four G proteins (Gs, Gt, Gi, and Go) were identified by biochemical purification, a large number of G proteins and their subunits were identified by cDNA cloning (2). G proteins consist of three subunits, alpha, beta, and gamma. When signaling, they function in essence as dimers because the signal is communicated either by the Ga subunit or the Gbg complex. In most cases, Gbg subunits cannot be dissociated under nondenaturing conditions. Currently there are 20 known G, 6 G, and 11 G subunits. (from Science 2002;296:1636-9)"                                          
[17654] "A transcription factor that belongs to the AP-2 family and binds viral and cellular enhancers containing the consensus 5'-GCCNNNGGC-3' DNA motif. AP-2 Gamma appears to regulate expression of genes required for ectodermal development. (from SWISS-PROT Q92754, OMIM 601602, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17655] "VAV1 protein is a proto-oncogene product with features of a transcription factor, including an N-terminal acidic region, a proline-rich region, and two zinc finger-like domains.  VAV also has an SH2, two SH3, and a guanosine exchange factor domain.  Truncation of its N-terminus, containing an HLH domain and leucine zipper, activates its oncogenic potential.  Wild type VAV is transcribed in hematopoietic cells, including erythroid, lymphoid, and myeloid lineages.  VAV-dependent signaling pathways regulate the maturation of T-cells.  (from OMIM 164875 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                               
[17656] "ST5 protein contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17657] "Nuclear Receptor Co-Repressor 1, encoded by the NCOR1, mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. This protein is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                       
[17658] "TRAP220 (thyroid hormone receptor-associated protein) is a recently cloned nuclear receptor coactivator, which interacts with several nuclear receptors in a ligand-dependent manner and stimulates transcription by recruiting the TRAP mediator complex to hormone responsive promoter regions. TRAP220 has been shown to interact with thyroid hormone receptors, vitamin D receptors, peroxisome proliferator-activated receptors, retinoic acid receptors and oestrogen receptors. Our work supports the assumption that TRAP220 plays an important role in growth and differentiation of central nervous system and may have a function in certain areas of adult brain. (from Eur J Neurosci. 2002;16:671-83)"                                                                                                                                                                                                                                                                               
[17659] "Caspase-10 originally was identified as a novel ICE/CED-3 protease, designated FLICE2 (FADD (fas-associated via death domain)-like ICE 2). It has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits TNFR1 to form complexes with these receptors. Caspase-10 is therefore involved in the TNFR1 induced apoptosis. Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8, and -9, which causes the proteolytic cleavage of many key proteins such as PARP (poly (ADP-ribose) polymerase). Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death."                                                                                                                                                                                                                                                                                                                                     
[17660] "ELK1 Protein is a member of the ELK subfamily of ETS DNA-binding transcription factors.  (from OMIM 311040 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17661] "Vascular Endothelial Growth Inhibitor is a TNF-related type II transmembrane protein, with an extracellular C-terminus, a single transmembrane domain, and a short cytoplasmic tail.  VEGI is expressed as multiple mRNAs in most tissues, arterial endothelial cells, and monocytes, but not in B- or T-cells.  Soluble VEGI markedly reduces vascularization and inhibits the growth of aortic endothelial cells and colon carcinomas.  VEGI appears to be an angiogenesis inhibitor that directly inhibits endothelial cell proliferation.  VEGI appears to cause endothelial cell apoptosis by activation of the SAPK/JNK stress protein kinases, p38 MAPK, and caspase-3.  (from OMIM 604052 and NCI)"                                                                                                                                                                                                                                                                                         
[17662] "Glutathione S-transferases (GSTs) are a family of phase II enzymes which comprise at least four classes, a, m, p and q. The GSTM1 gene is one of the m-class forms and is classified into three genotypes, GSTM1A, GSTM1B, and GSTM1 (0/0). The GSTM1 (0/0) genotype due to inherited homozygous deletion of both alleles has no enzymatic activity.  The GSTM1 (0/0) genotype has been possibly implicated in elevated risks of lung and urothelial cancer. (Japanese Journal of Clinical Oncology,Pages 657-660)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17663] "Encoded by human RALA Gene (RAS GTPase Family), 206-aa 24-kDa GTP-binding RAS-like RALA Protein interacts with RALBP1 via its effector domain and likely mediates some cell surface transmembrane receptor signaling. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17664] "Translocation t(11;17)(q23;21) fuses the PLZF gene on 11q23.1 to the RARA gene on chromosome 17 producing a 'dominant-negative' PLZF-RARA fusion protein in myeloid cells and resulting in APL.  The oncogenic retinoic acid receptor mediates leukemogenesis through aberrant chromatin acetylation.  Through the RAR-alpha CoR box, PLZF-RAR-alpha fusion proteins recruit the NCOR/histone deacetylase complex.  (from OMIM 176797 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17665] "RAL proteins share homology and some properties with the RAS proteins.  RALB is a GTP-binding protein.  (from OMIM 179551 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17666] "One of three identified histone deacetylases with similarity to the yeast global transcriptional regulator Rpd3p, HDAC2 is found in transcription factor co-repressor complexes that include HDAC1.  BRCA1 interacts with HDAC1 and HDAC2.  Acetylation of histone destabilizes nucleosomes allowing transcription factors access to recognition elements in DNA.  Deacetylation reseals the chromosomal package, repressing transcription.  DNMT1 can establish a repressive transcription complex with HDAC2, and DMAP1.  HDAC2 joins DNMT1 and DMAP1 during late S-phase, suggesting how histones may become deacetylated in heterochromatin following replication.  (from OMIM 605164 and NCI)"                                                                                                                                                                                                                                                                                                 
[17667] "Expressed in prostate, kidney, lung, small intestine, stomach, colon, placenta, spleen, liver, leukocytes, and thymus, human ST14 Gene (Peptidase S1 Family) encodes an 855-aa 95-kD membrane-associated serine protease, Matriptase. ST14 contains an N-region integrin-binding site, N-glycosylation sites, tandem LDLR class A cysteine repeats, CUB domains, a putative proteolytic activation site, a C-terminal trypsin-like serine protease region, an S1 pocket, an S2 subsite, and an S4 cavity. Protease specificity involves additional cleavage site residues. Complexed with 40-kD SPINT1, a Kunitz-type inhibitor, ST14 is activated by sphingosine 1-phosphate, degrades extracellular matrix, and cleaves/activates HGF and urokinase plasminogen activator. ST14 may play a role in cancer invasion and metastasis. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                   
[17668] "A group of proteins secreted by the pancreas that aid in the digestion of food."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17669] "A genetic complementation group for X-ray sensitivity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17670] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17671] "Short repeats of nucleotide sequences present throughout the genome which exhibit variations within a population."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17672] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17673] "The TAL1 gene is associated with T-cell leukemia, due to gene deletion or translocation.  TAL1 gene products, possible transcriptional regulatory factors, possess the bHLH motif, a DNA-binding domain common to many transcription factors.  TAL1 can form heterologous complexes with E47 or E12 that recognize the E-box DNA motif.  TAL1 appears to be essential for embryonic blood formation. The human gene is located at 1p32."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17674] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17675] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17676] "Related by decent from a single progenitor cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17677] "Human androgen receptor gene assay.  This assay was used to detect X chromosomal inactivation for diagnosis of X-linked conditions, ie. Kennedy disease, agammaglobulinemia, and others."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17678] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17679] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17680] "Generally expressed in monocytes, macrophages, polymorphonuclear cells, NK cells, T- and B-lymphocytes, and platelets, Fc-Gamma Receptors II are type I cell surface membrane protein low affinity receptors for aggregated IgG Fc region with 2 extracellular IgC2 domains and cytoplasmic ITIM or ITAM motifs involved in cell activation upon receptor aggregation. IgG binding initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. (NCI)"                                                                                                                                                                                                                                                                                                                                                            
[17681] "Chemical or physical tests to determine DNA sequence variation"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17682] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17683] "A bladder cancer modifier, human NAT2 Gene (NAT family) at 8p23.1-p21.3 encodes an Arylamine N-Acetyltransferase family member responsible for N-acetylation of carcinogens.  None of the coding sequence is interrupted by introns.  NAT1 and NAT2 code for genetically invariant and variant NAT proteins, respectively.  NAT1 is responsible for N-acetylation of certain arylamine drugs, whereas rapid and slow acetylation of therapeutic and carcinogenic agents is due to genetic variation in the NAT2 coding region.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17684] "Encoding a transcription factor with HLH motif and ETS DNA-binding domain, human ETV6 Gene (ETS Family) at 12p13 includes the TEL oncogene.  The 240 kb gene is flanked by D12S1697 (5-prime) and D12S98 (3-prime); D12S1095 and D12S89 are located in the first intron.  The HLH motif is coded by exons 3-4; exons 6-8 encode the ETS domain.  ETV6 is specifically required for hematopoiesis within the bone marrow.  Frequently rearranged in myeloid or lymphoid leukemias, TEL exhibits fusion translocations with PDGFRB, AML1, KIP, MN1, NTRK3, ACS2, ABL2, BTL, ARNT, and JAK2. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                         
[17685] "A test to measure the amount of certain proteins, called hormone receptors, in cancer tissue. Hormones can attach to these proteins. A high level of hormone receptors may mean that hormones help the cancer grow."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17686] "In cancer, refers to how mature (developed) the cancer cells are in a tumor. Differentiated tumor cells resemble normal cells and tend to grow and spread at a slower rate than undifferentiated or poorly differentiated tumor cells, which lack the structure and function of normal cells and grow uncontrollably."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17687] "A procedure used to examine the prostate. An instrument is inserted into the rectum, and sound waves bounce off the prostate. These sound waves create echoes, which a computer uses to create a picture called a sonogram."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17688] "A picture of the body recorded on paper rather than on film. Also called a xeroradiograph."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17689] "SPF. A scale for rating the level of sunburn protection in sunscreen products. The higher the SPF, the more sunburn protection it provides.  Sunscreens with an SPF value of 2 through 11 provide minimal protection against sunburns.  Sunscreens with an SPF of 12 through 29 provide moderate protection, which is adequate for most people.  Those with an SPF of 30 or higher provide high protection against sunburn and are sometimes recommended for people who are highly sensitive to the sun."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17690] "An antiviral gene being studied for treatment of cancer in patients who have HIV, the virus that causes AIDS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17691] "Part of the heterodimeric transcription factor Core-Binding Factor.  The CBFalpha subunit binds directly to the enhancer core DNA sequence on target genes, whereas the beta subunit does not bind the DNA directly but increases the affinity and stabilizes the binding of the alpha subunit to the DNA.  Three homologous genes can encode for the CBFalpha subunit.  Disruption of CBFA2 is associated with many leukemias, including AML, ALL, and CML."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17692] "ETO is a putative transcription factor containing one MYND-type zinc finger and most abundantly expressed in the brain.  Two isoforms, MTG8A and MTG8B, are produced by alternative splicing.  (from Swiss-Prot Q06455 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17693] "Human FLI1 Gene (ETS family) at 11q24 encodes ERGB Transcription Factor, which contains a PNT domain and recognizes 5 prime-C(CA)GGAAGT-3 prime DNA.  Two isoforms may be produced by alternative splicing.  ETS1 and FLI1 reside within 400 kb and are transcribed in the same orientation.  The gene is flanked centromerically by an ALL-associated t(4;11)(q21;q23) translocation breakpoint and telomerically by a Ewing-associated t(11;22)(q24;q12) breakpoint.  FLI1 protein forms homodimers, or heterodimers with ETV6/TEL1.  ETS transcription factors regulate TGFBR2 gene expression. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                           
[17694] "Containing Ewing sarcoma breakpoint region 1, human EWSR1 Gene (TET Family) at 22q12 encodes a putative RNA-binding protein that may function as a repressor.  Differential splicing produces two transcripts expressed in a variety of cells.  The N-terminal domain may regulate specificity of the EWS RNA-binding activity.  Possible members of a new family of RNA binding proteins, RBP56, FUS/TLS, and EWS may be derived from an ancestral gene.  A large group of Ewing sarcoma cases result from translocations involving FLI1 or ERG; the chimeric product contains a DNA-binding domain of these ETS factors in place of the EWSR1 RNA-binding domain.  Desmoplastic small round cell tumor is associated with a chromosomal translocation involving WT1 and EWS.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                   
[17695] "The tumor suppressor CDKN2B gene encodes cyclin-dependent kinase inhibitor 2B, a member of the p16(INK4) family referred to as p15(INK4B).  Expression of CDKN2B is induced by TGF beta, suggesting that p15 may act as an effector of TGFB-mediated cell cycle arrest in growth regulation.  The human gene is located at 9p21."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17696] "Caspase-activated BID triggers homooligomerization of BAX, the BAX gene product. Insertion of cytosolic BAX into mitochondrial membranes stimulates apoptosis. BAX shows extensive amino acid homology with BCL2 and forms homo- and heterodimers with BCL2, which controls mitochondrial membrane permeability. The ratio of BAX to BCL2 may determine survival or death following an apoptotic stimulus. BAX binds to PTPC, the mitochondrial porin channel VDAC, involved in regulation of mitochondrial membrane permeability. BAX and mitochondrial protein ANT cooperate within PTPC to increase mitochondrial membrane permeability, which causes release of cytochrome C into the cytoplasm, activating death-driving proteolytic caspases. The BAX gene at 19q13.3-q13.4 encodes at least four proteins by alternate splicing. Its promoter contains consensus p53-binding sites. A primary-response gene for p53, BAX is involved in a p53-regulated pathway for induction of apoptosis." 
[17697] "The C-MET gene is a cloned gene for Hereditary Papillary Renal Carcinoma, associated with renal cancer.  c-MET is related to the insulin receptor and ABL oncogene.  A cell surface receptor-like tyrosine kinase comprised of disulfide-linked 50 kD (alpha) and 145 kD (beta) subunits.  In the fully processed c-MET product, the alpha subunit is extracellular, and the beta subunit has extracellular, transmembrane, and tyrosine kinase domains, as well as sites of tyrosine phosphorylation.  The beta subunit of the c-MET proto-oncogene product is the cell surface receptor for hepatocyte growth factor.  The human gene is located at 7q31."                                                                                                                                                                                                                                                                                                                                        
[17698] "The Ets family of transcription factors includes nuclear phosphoproteins that are involved in cell proliferation, differentiation and oncogenic transformation. The family is defined by a conserved DNA-binding domain (the ETS-DBD), which forms a highly conserved, winged, helix-turn-helix structural motif. As targets of the Ras-MAPK signaling pathway, Ets proteins function as critical nuclear integrators of ubiquitous signaling cascades. To direct signals to specific target genes, ETS proteins interact with other transcription factors that determine the binding specificity of ETS proteins to RAS-response elements in target genes."                                                                                                                                                                                                                                                                                                                                        
[17699] "Human ETS1 Gene (ETS Family) at 11q23.3 expresses a 6.8 kb mRNA that encodes 42-52 kD DNA-binding phosphoprotein transcription factors that interact with purine-rich sequences in promoter/enhancer regions of genes, such as TCRA and p16(INK4A).  The ETS family includes ETS1, ETS2, ERG, ELK1, and ELK2. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17700] "Human ETS2 Gene (ETS Family) at 21q22.3 encodes a DNA-binding transcription factor expressed in a variety of cell types.  ERG is situated just proximal to ETS2, which has no promoter TATA box or CAAT box; it has an alternative structure that serves a comparable function.  Activity of the product is potentiated by the RAS-RAF-MEK cascade and inhibited by the HLH protein ID1.  ETS2 appears to have a role in skeletal development.  The ETS family includes ETS1, ETS2, ERG, ELK1, and ELK2.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17701] "Disease Marker; any characteristic that indicates the presence of a disease"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17702] "Involved in breast tumor cell metastasis, the 8.5 kb human NM23 Gene (NDK family) at 17q21.3 consists of four introns and five exons encoding nuclear/cytoplasmic Nucleoside Diphosphate Kinase A (p19/NM23) whose expression correlates with cell proliferation and inversely with metastatic potential.  The exon-intron boundaries are well conserved.  The serine phosphorylated A/B hexamer participates in nucleoside triphosphate synthesis, other than ATP.  Murine NM23 is a myeloid differentiation-inhibiting factor.  Human NM23 is also similar to awd (Drosophila), a putative transcription factor; awd mutations cause abnormal morphology and aberrant differentiation.  A high purine DNA-binding factor, NM23 is PuF transcription factor, which binds to a MYC P1 promoter element and activates MYC P1 and P2 transcription initiation.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                     
[17703] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17704] "A transforming gene activated in certain human B lymphoid tumors, B-lym was originally detected by transfection of NIH 3T3 cells with DNA from Burkitt lymphomas.  B-lym contains regions of similarity to the amino terminal region of transferrins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17705] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17706] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17707] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17708] "Human MEL Gene (RAB/YPT Family/RAS Superfamily) encodes 207-aa 24-kDa RAB8 Protein, containing the 4 GTP/GDP-binding sites present in all RAS small GTPase GTP/GDP-binding proteins and a C-terminal CAAX motif characteristic of many RAS members but not found in YPT1 and most RAB proteins. RAB8 does exhibit strong similarity with mammalian YPT1 proteins; the putative effector-binding site is similar to that of RAB/YPT proteins. Like other RAB/YPT family proteins, RAB8 may play a role in protein transport from endoplasmic reticulum to Golgi and plasma membrane, vesicular trafficking, or neurotransmitter release. RAB8 may interact with MAP4K2 and SYTL4. (NCI)"                                                                                                                                                                                                                                                                                                             
[17709] "Serine/threonine-protein kinase; regulated by hematopoietic cytokine receptors; synergy with c-MYC in cell proliferation and in apoptosis induction (through an enhancement of the activation of caspase-3 -like proteases; Cdc25A (cell cycle phosphatase) is a substrate for Pim-1."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17710] "Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                       
[17711] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17712] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17713] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17714] "Oncogenes that encode nuclear proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17715] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17716] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17717] "Flanked by microsatellites D12S80 and D12S83, human MDM2 Gene (MDM2/MDM4 family) at 12q14.3-q15 encodes a 90 kD ubiquitin ligase E3 phosphoprotein that complexes with p53 in S/G2/M, targeting its degradation and inhibiting p53-mediated gene transactivation.  The 25 kb murine gene contains at least twelve exons and MDM2 expression is regulated by the RAS/MAPK pathway.  Upon DNA damage, phosphorylation of p53 suppresses interaction with MDM2 and p14(ARF) inhibits MDM2 activity.  Interaction with MDM2 inhibits RB protein.  MDM2 amplification is found in some cancers and may lead to escape from p53-regulation of growth control. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                           
[17718] "The 30 kb human Notch-4 Gene (Notch family) at 6p21.3 resides in a MHC class III/II junction region and contains thirty exons widely expressed as a major 6.7 kb Notch-4(S), and a 9.3 kb Notch-4(L), mRNA.  Incompletely spliced Notch-4(L) potentially encodes two proteins; one is similar to the INT3 oncoprotein, the other consists of the first seven EGF repeats.  Notch-4 may have experienced segmental duplication during evolution.  The transmembrane receptor of a conserved intercellular cell fate signaling mechanism, Notch-4 protein contains twenty-nine EGF-like repeats and three Notch/lin-12 repeats in the extracellular region.  Six cdc10/ankyrin repeats, a polyglutamine domain, and a C-terminal PEST region comprise the intracellular region.  INT3 interruption of Notch-4 produces a truncated gain-of-function product that has profound consequences for mammary gland development and tumorigenesis.  (from OMIM and NCI)"                                     
[17719] "The EIF3S6 gene is a putative tumor suppressor gene, encoding the p48 subunit of EIF3, that is highly conserved evolutionarily and widely expressed.  EIF3 is the largest EIF, consisting of at least 10 non-identical subunits in mammals.  EIF3S6 is identical to the INT6 gene product, one of eight genes found genetically altered by MMTV integration in various mammary tumors.  Interruption of INT6 by MMTV integration results in a dominant-negative or biological activation of function of p48.  The huamn gene is located at 8q22-q23."                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17720] "Cloned cancer gene for Familial gastrointestinal stromal tumors (GIST), KIT proto-oncogene encodes a putative transmembrane receptor tyrosine kinase for stem cell factor and is critical in the development of pluripotent hematopoietic stem cells, migrating embryonic melanoblasts, and primordial germ cells.  The human proto-oncogene is located at 4q12."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17721] "The gene product of oncogene YES-1 is associated with tyrosine kinase activity and its amino acid sequence shows high similarity with that of SRC. Multiple copies of YES-related genes occur in the human genome. Oncogene YES-1 is located at 18p11.31-p11.21."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17722] "Human AKT1 Gene (RAC family) at 14q32.3, proximal to the Ig heavy chain loci, encodes RAC-Alpha (serine/threonine) protein kinase activated by PI3K and containing SH2-like domains, with sequence similarity to PKC and cAMP-dependent protein kinase.  In response to survival factors, AKT1 activates IKBKA, inactivates apoptotic components including BAD and caspase-9, and inactivates transcription factor FKHRL1, an activator of cell death genes.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17723] "Human WNT5A Gene (WNT Family) encodes 365-aa 41-kDa (precursor) WNT5A Protein, a cysteine-rich secreted glycoprotein growth factor involved in embryonic cell migration and axis induction. Frizzled-5 is a 7 transmembrane receptor for WNT5A ligand, which shows 98%, 98% and 87% amino acid identity to mouse, rat, and xenopus Wnt5A proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17724] "One of two cellular homologues of the v-AKT oncogene of retrovirus AKT8, human AKT2 Gene (RAC family) at 19q13.1-q13.2 encodes PI-dependent RAC-Beta (serine/threonine) protein kinase, containing SH2-like domains, expressed in insulin-responsive tissues, and implicated in the glucose homeostatic actions of insulin.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17725] "The WNT2 gene encodes a secreted growth factor member of the INT1 gene family and is associated with breast cancer.  The human gene is located at 7q31."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17726] "Human ARAF1 Gene (MIL/RAF family) at Xp11.4-p11.2, 10-17 cM proximal to the HPRT gene, encodes a cytoplasmic A-RAF serine/threonine protein kinase, containing a DAG binding domain and involved in transduction of mitogenic signals from cell membrane to nucleus.  A 2.4 kb mRNA is produced, which comprises sixteen exons spanning by a minimum of 10.8 kb.  In mouse, ARAF1 is expressed predominantly in urogenital tissues.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17727] "The WNT1 gene encodes INT1/WNT1, a cysteine-rich putative secreted glycoprotein homologous to the Drosophila segment polarity gene wingless product.  It is probably a signaling protein acting in CNS mesencephalic and metencephalic development.  The human gene is located at 12q13."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17728] "Human ARHA Gene at 3p21.3 encodes a RHO GTPase member of the RAS-related GTP-binding protein family.  RHOA is a small guanosine triphosphatase that regulates remodeling of the actin cytoskeleton during cell morphogenesis and motility.  Active RHOA signals its downstream effector ROCK1 to phosphorylate and activate LIM kinase to phosphorylate cofilin, inhibiting its actin-depolymerizing activity.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17729] "Human ARHB Gene at 2pter-p12 encodes a RHO GTPase member of the RAS-related GTP-binding protein family.  RHOB is a small guanosine triphosphatase that regulates remodeling of the actin cytoskeleton during cell morphogenesis and motility.  Phosphorylated and activated by ROCK, an effector of RHOB, LIM kinase phosphorylates cofilin, inhibiting its actin-depolymerizing activity.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17730] "Human ARHC Gene at 1p21-p13 encodes a RHO GTPase member of the RAS-related GTP-binding protein family.  RHOC is a small guanosine triphosphatase that regulates remodeling of the actin cytoskeleton during cell morphogenesis and motility.  Active RHOC signals its downstream effector ROCK1 to phosphorylate and activate LIM kinase to phosphorylate cofilin, inhibiting its actin-depolymerizing activity.  RHOC is important in tumor cell invasion. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17731] "Human AXL Gene (AXL/UFO family) at 19q13.1-q13.2 is transcribed into a 5.0 kb and a 3.2 kb mRNA that encodes a conserved transmembrane GAS6 receptor tyrosine kinase with a novel structure.  AXL is widely expressed in mouse monocytes and macrophages, but not in B- or T-lymphocytes.  The cellular function of AXL in non-transformed cells is unclear.  AXL was originally identified as an oncogene (due to over expression) in two chronic myelogenous leukemia patients.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17732] "The BCL3 Gene was originally identified as a gene located in the breakpoint region of t(14;19)(q32;13.1), also involving the Ig gene region, in a patient with chronic lymphocytic leukemia.  A possible transcription activating factor containing ankyrin repeats, BCL3 is activated by phosphorylation and functions as an IKB specific for p50/NFKB homodimers, inhibiting nuclear translocation.  BCL3 confers a survival advantage to T-cells, possibly by promoting the expression of genes repressed by NFKB members such as REL.  The human gene is located at 19q13."                                                                                                                                                                                                                                                                                                                                                                                                                     
[17733] "The VAV2 oncogene encodes VAV2, of the VAV oncoprotein family, which acts as a guanosine nucleotide exchange factor (GEF) for RHOG and RHOA-like GTPases.  Integrin-induced phosphorylation of VAV2 requires SYK.  VAV2 contains a calponin-homology domain, a DBL-homology domain, a PH domain, a DAG binding domain, an SH2 domain, and SH3 domains.  The human gene is located at 9q34.1."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17734] "Originally identified by provirus tagging in mice as an oncogene that synergizes with MYC in pre-B cell lymphomagenesis, the BMI1 gene encodes a highly conserved nuclear protein containing a novel putative zinc finger and a domain of homology to a Drosophila Polycomb protein.  BMI1 appears to be a member of a vertebrate Polycomb complex that regulates segmental identity by repressing HOX genes throughout development.  BMI1 and RING1 may be part of a protein complex.  The human gene is located at 10p13."                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17735] "A homologue of the avian c-Rmil protooncogene, human BRAF Gene (MIL/RAF Family) at 7q34 encodes a 94 kD serine/threonine kinase signaling factor critical in formation of the vascular system.  Avian BRAF sequences are encoded by three exons, which are conserved in human BRAF.  Fusion of TIF1A to BRAF by chromosomal translocation results in production of a TIF1-Alpha-B-RAF oncoprotein.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17736] "The CBL gene, cellular homologue of v-cbl, is expressed in a range of hematopoietic lineages and encodes adaptor protein CBL, containing a RING finger and multiple SH3 domains, a protein similar to SLI1, a negative regulator of an EGF receptor tyrosine kinase homologue.  Through its SH2 domain, CBL regulates activated tyrosine-phosphorylated receptor PTK ubiquitination as an E3 ubiquitin ligase and recruits, and activates, an E2 ubiquitin-conjugating enzyme through its RING domain.  CBL is recruited to the tyrosine kinase insulin receptor by CAP adaptor protein, through a CAP SH3 domain.  Upon CBL phosphorylation, CAP/CBL dissociates from the receptor to complex with caveolar flotillin and localize to plasma membrane lipid rafts.  Malignancies are associated with translocations of CBL.  The human gene is located at 11q23.3.(LocusLink)"                                                                                                                     
[17737] "VAV plays a role in T- and B-cell development and activation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17738] "The tumor suppressor TP73 gene encodes a 73 kD protein with sequence similarity to p53.  p53 residues implicated in DNA binding are conserved in p73, which appears to activate some p53-responsive genes and to induce apoptosis.  p73 and c-ABL may participate in a mismatch repair-dependent pro-apoptotic signaling pathway.  p73 and c-ABL associate through interaction of a c-ABL SH3 domain with a p73 PXXP motif in the C-terminal homooligomerization domain.  p73 is a c-ABL kinase substrate; p73 phosphorylation is enhanced by gamma-irradiation.  c-ABL stimulates p73-mediated transactivation and apoptosis.  T-cells undergoing TCR-AICD, in a late G1 cell-cycle checkpoint, are dependent on E2F1 and TP73.  Expression of E2F1 causes accumulation of p73.  The human gene is located at 1p36."                                                                                                                                                                               
[17739] "The TP53BP2 gene encodes a protein that binds to the p53 tumor suppressor protein and interacts with BCL2.  TP53BP2 does not induce apoptosis but does impede cell cycle progression beyond G2/M.  The TP53BP2 SH3 domain and ankyrin repeats are required for interaction with p53 and with BCL2; TP53BP2 cannot bind to both proteins simultaneously.  TP53BP2 enhances p53 DNA binding and transactivation of pro-apoptotic genes, such as p21CDKN1A.  The human gene is located at 1q42.1."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17740] "The TNF gene encodes tumor necrosis factor, a multifunctional pro-inflammatory cytokine with effects on lipid metabolism, coagulation, insulin resistance, and endothelial function.  Activated macrophages constitute the major cellular origin of TNF. TNF alpha and TNF beta share a common receptor on tumor cells and are up regulated by gamma-interferon.  TNFA stimulates prolonged expression of the JUN oncogene.  The human gene is located at 6p21.3."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17741] "Oncogene TIM encodes a predicted 60 kD protein containing a DBL homology domain, shared by several signal transducing regulators of small GTP-binding proteins. TIM is thought to control cytoskeletal organization through regulation of small GTP-binding proteins. The human gene is located at 7q33-q35."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17742] "The TIAM1 gene encodes a serine-rich protein that contains a DBL homology (DH) domain, a PDZ/DHR domain, and two pleckstrin-homologous (PH) domains.  The DH domain is found in GDP-GTP exchanger proteins that activate RHO-like GTPases and PH domains are thought to be involved in protein-protein interactions.  TIAM1 appears to modulate activation of the GDP-GTP exchange activity of RHO-like GTPases that regulate cytoskeletal organization.  TIAM1 activates RAC1, CDC42, and to a lesser extent RHOA.  The human gene is located at 21q22.1."                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17743] "The tumor suppressor candidate CDKN1C gene encodes cyclin-dependent kinase inhibitor 1C (p57(KIP2) containing an N-terminal CDK inhibitory domain with significant similarity to p21(CIP1).  p57(KIP2) protein is a potent tight-binding inhibitor of several G1 cyclin/CDK complexes and a negative regulator of cell proliferation.  The human gene is located at 11p15.5."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17744] "The CHES1 gene encodes CHES1 protein, a member of the forkhead family of transcription factors.  Originally isolated from a human glioblastoma cDNA library, it suppresses S. cerevisiae checkpoint mutations.  CHES1 may function in DNA damage-inducible cell cycle arrests, or checkpoints, at G1 or G2.  The human gene is located at 14q24.3-q31."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17745] "The 8-exon 28-kb human MAP3K8 Gene (MAP3K Family) at 10p12.1 encodes cytoplasmic 58-kD (S and G2/M phase specific) and 52-kD isoforms of (Ser/Thr) MAP Kinase Kinase Kinase 8, produced by alternative initiation, that activates MAP kinase and JNK kinase pathways in cell cycle regulation. Ser/Thr and autophosphorylated p38 MAPK activates IKB kinases, inducing proteasome-mediated proteolysis of cytoplasmic NFKB and nuclear translocation, and promotes TNF-alpha and IL-2 production during T lymphocyte activation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17746] "The CRK gene is the homologue of the transforming oncogene of the avian sarcoma virus CT10.  The encoded protein contains SH2 and SH3 homology domains.  The gene maps to a region of chromosome 17p presumed to harbor a tumor suppressor gene.  CRK interacts with ABL via SH2 and SH3 domains.  The human gene is located at 17p13.3."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17747] "The CRKL gene, an oncogene transduced by the avian sarcoma virus CT10, encodes a non-receptor tyrosine kinase similar to CRK, and to other protein tyrosine kinases with SH2 and SH3 domains.  CRKL appears to activate RAS-dependent and JNK pathways.  CRKL appears to be a substrate for the BCR-ABL tyrosine kinase.  The human gene is located at 22q11."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17748] "One of three loci rearranged with the RET gene in papillary thyroid carcinomas, human H4 Gene at 10q21 has no known function and shows no homology to any known gene.  A putative N-terminal leucine zipper mediates H4 protein dimerization.  (from OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17749] "The THRB gene is a retrovirus-associated erbA DNA sequence originally isolated from the avian erythroblastosis virus.  The erbA-related proto-oncogenes encode thyroid hormone receptors.  Multiple high-affinity thyroid hormone receptors may bind to DNA and activate transcription and there may be as many as five thyroid hormone receptor-encoding loci in the human genome.  Two distinct ERBA proto-oncogenes have been identified, ERBA-alpha and ERBA-beta, each giving rise to at least two proteins.  THRB2 (ERBA-beta) is a thyroid hormone receptor transcription factor present in liver, heart, and brain.  The human gene is located at 3p24."                                                                                                                                                                                                                                                                                                                                    
[17750] "The DDX6 gene encodes DEAD/H BOX 6, a putative RNA helicase/translation initiation factor, associated with hematopoietic tumors containing 11q23 translocations.  DEAD box proteins are putative RNA helicases that have a characteristic Asp-Glu-Ala-Asp (DEAD) box as one of eight highly conserved sequence motifs.  The human gene is located at 11q23.3."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17751] "The E2F1 gene at 20q11.2 encodes E2F1, which binds DNA as homo- or heterodimers with DP1 or DP2. E2F1 transactivates p53 and p73. MYC-induced apoptosis involves E2F1. E2F1 can induce apoptosis in a p53-independent manner through accumulation of p73 or through a death receptor-dependent mechanism by down regulating TRAF2 and inhibiting activation of NFKB anti-apoptotic signals. E2F1 also induces p53-dependent apoptosis by inducing ARF, which neutralizes MDM2 and stabilizes p53. TCR-AICD, in a p53-independent late G1 phase cell-cycle checkpoint, is dependent on E2F1 and TP73. E2F is a critical determinant of G1/S transition, activating transcription of genes necessary for DNA replication. RB interacts with E2F factors to arrest cells in G1 by active transcriptional repression. RB-E2F repression mediates G1 arrest triggered by TGFB, by p16, and by contact inhibition. Accumulation of G1 cyclins E and D1 is regulated by E2F1. (from OMIM 189971 and NCI)"  
[17752] "The THRA gene is a retrovirus-associated erbA DNA sequence originally isolated from the avian erythroblastosis virus.  The erbA-related proto-oncogenes encode thyroid hormone receptors.  Evidence indicates the presence of many high-affinity thyroid hormone receptors that activate transcription and perhaps as many as five receptor-encoding loci in the human genome.  Two ERBA proto-oncogenes have been identified, ERBA-alpha (ERBA1) and ERBA-beta (ERBA2), giving rise to at least two proteins each.  ERBA1 encodes ERBA alpha-1, and ERBA alpha-2 by alternative splicing.  THRA1 (ERBA-alpha1) is expressed in many tissues, with highest levels in the central nervous system and no expression in the liver.  THRA2 (ERBA-alpha2) is expressed in liver, kidney, placenta, and brain.  The human gene is located at 17q21."                                                                                                                                                      
[17753] "The proto-oncogene NCOA4 encodes ARA(70), a ligand-dependent co-activator protein that enhances specific androgen receptor transcriptional activity.  Illegitimate recombination with the RET gene results in the RET/PTC3 oncogene, a tumor specific rearrangement of the RET gene detected in papillary thyroid carcinomas.  The androgen receptor is a transcription factor of the steroid receptor superfamily.  Although several steroid-class receptors recognize the same DNA regulatory sequence, gene-specific activation may be achieved by selective accessory factors that interact with the receptors to determine specificity of target gene activation."                                                                                                                                                                                                                                                                                                                             
[17754] "Human EMS1 Gene at 11q13 encodes variants of cytoplasmic Cortactin, an actin-binding protein involved in restructuring the cortical cytoskeleton and organizing epithelial cell structure. Like murine Cttn, Cortactin is located in cell-substratum contact areas and contains one SH3 domain that may bind to the cytoskeleton. It also regulates interactions between adherens junction components. It may interact with SHANK2 and SHANK3 via its SH2 domain. As a pp60v-SRC substrate, Cortactin phosphorylation may regulate cell growth. EGF enhances p80 to p85 conversion by phosphorylation. Posttranslational modification of Cortactin coincides with redistribution to cell-matrix contact sites. Caspase-dependent degradation of Cortactin occurs during apoptosis. Aberrant gene regulation contributes to tumor cell invasion and metastasis. (from Swiss-Prot Q14247, OMIM 164765, and NCI)"                                                                                      
[17755] "Human EPHA1 Gene (EPH Family) at 7q32-q36 encodes ephrin receptor EPHA1, a tyrosine kinase implicated in nervous system development, and elsewhere.  Exon splice sites for the kinase domain are distinct from other tyrosine kinase genes, suggesting an early evolutionary split.  EPHA1 mRNA is detected in rat liver, lung, kidney, and testes; human expression appears to be preferential for epithelial cells.  Axonal EPHA receptors interact with ephrin-A ligands, anchored to the plasma membrane by glycosylphosphatidylinositol linkage.  Over expression has been found in hepatoma and lung cancer without gene amplification.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                    
[17756] "Human EPHA3 Gene (EPH Family) at 3p11.2 encodes EPHA3 ephrin receptor tyrosine kinase.  Expressed as a single transcript in a variety of human tissues, EPHA3 may play a role in some human lymphoid malignancies and in normal lymphoid function and differentiation.  EPH receptors typically have a single kinase domain and an extracellular region containing a cysteine-rich domain and two fibronectin type III repeats.  EPHA receptors interact preferentially with ephrin-A proteins, ligands anchored to the plasma membrane by glycosylphosphatidylinositol linkage. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                  
[17757] "Highly expressed in fetal liver, human NR2F6 Gene (NR2 family) on chromosome 19 encodes EAR2, containing a DNA-binding domain and similar in primary structure to receptors for steroid and thyroid hormones. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17758] "Human ERBB3 Gene (ERBB Family) at 12q13 encodes EGFR3, a predicted 148 kD transmembrane polypeptide related to but distinct from EGFR, ERBB2, and ERBB4.  A 6 kb transcript is found in various tissues.  ERBB2, ERBB3, and ERBB4 encode homo- and heterodimeric heregulin/neuregulin receptors.  ERBB3 is capable of mediating HGL-stimulated tyrosine autophosphorylation.  Elevated transcript levels are seen in certain mammary tumor cell lines, suggesting a role in some malignancies.  The gene is frequently over expressed in solid tumors, including breast cancer. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                   
[17759] "The SUPT3H gene is an homologue of the yeast Spt3 gene, a transcription factor required for expression of many RNA polymerase II-transcribed genes.  The SUPT3H gene product is a subunit of the P/CAF complex.  The human gene is located at 6p21.1-p21.3."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17760] "Human ERBB4 Gene (ERBB Family) at 2q33.3-q34 encodes HER4/ERBB4, an EGFR-related type I receptor tyrosine kinase.  Like EGFR, ERBB2, and ERBB3, ERBB4 is located in close proximity to homeobox and collagen gene loci.  ERBB2, ERBB3, and ERBB4 encode homo- and heterodimeric heregulin/neuregulin receptors.  ERBB4 is enriched in the post-synaptic density, associates with PSD95 (which may facilitate ERBB4 dimerization), and appears to enhance NRG activation of ERBB4 and MAP kinase.  NRG/ERBB4 signaling in the adult central nervous system may modulate synaptic plasticity.  ERBB4 is frequently over expressed in solid tumors, including breast cancer. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                         
[17761] "The SUPT5H gene is an homologue of the Spt5 gene, a yeast transcription factor.  Highly acidic and reversibly phosphorylated during mitosis, SUPT5H contains MAP kinase consensus sequences and is believed to be part of a chromatin modulating complex involved in transcriptional repression.  Also, a possible homologue of zebrafish 'foggy', which affects neuronal development.  Foggy is not part of the transcription apparatus, but a phosphorylation-dependent dual regulator of transcription elongation.  The human gene is located at 19q13.1-q13.2."                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17762] "The SUPT6H gene is an homologue of the yeast Spt6 gene, a chromatin structure regulator.  SUPT6H has features consistent with a nuclear protein that regulates transcription: a highly acidic 5-prime region, a degenerate SH2 domain, and a leucine zipper.  SUPT6H may regulate transcription through establishment or maintenance of chromatin structure.  The human gene is located at 17q11.2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17763] "Human ETV3 Gene (ETS Family) at 1q21-q23 encodes a transcription factor with the conserved ETS domain motif, which mediates sequence-specific DNA binding.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17764] "Human EVI1 Gene at 3q26 encodes a protein with multiple zinc-finger repeats common in transcriptional regulatory proteins.  Activation by retroviral insertion is frequently found in murine myeloid leukemias and leukemia cell lines.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17765] "SPI1 is an oncogene specifically activated in acute murine erythroleukemias, induced by the Friend spleen focus forming virus.  It encodes the transcription factor PU.1, normally expressed in all hematopoietic lineages except in T-cells. An ETS-domain transcription factor essential for the development of myeloid (osteoclast progenitors) and B-lymphoid cells. Graded expression of this transcription factor appears to specify distinct cell fates in the hematopoietic system. A low concentration of PU.1 protein induces the B-cell fate, whereas a high concentration promotes macrophage differentiation. PU.1 is thought to regulate transcription of FMS and CD18/11B, proteins central to the osteoclast phenotype, and is required for p47-phox promoter activity in myeloid cells. PU.1 expression is increased with the induction of osteoclastogenesis by 1, 25-dihydroxyvitamin D3. The human gene is located at 11p11.2."                                                 
[17766] "The tumor suppressor SMARCB1 gene, inactivated in malignant rhabdoid tumors, encodes a member of the chromatin-remodeling SWI/SNF multi-protein complex.  The human gene is located at 22q11.2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17767] "Refers to specific proteins or other factors in actively growing and dividing cells, whose presence serves as an indicator for such cells.  For instance, proliferating cell nuclear antigen (PCNA) or mitotic index."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17768] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17769] "The FAT gene encodes a homologue of the Drosophila 'fat' tumor suppressor protein, possessing 34 cadherin repeats and other characteristics.  The transmembrane protein might be involved in mammalian developmental processes and cell communication and/or adhesion.  Loss-of-function FAT mutations lead to hyperplastic overgrowth that maintains normal epithelial organization and differentiation, indicating that contact-dependent cell interactions may play an important role in regulating growth.  The human gene is located at 4q34-q35."                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17770] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17771] "This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17772] "CSVTCG-Specific Receptor (GP IV) is the receptor for thrombospondins in platelets and various cell lines.  GP IV is also the primary receptor for platelet adhesion to collagen and mediates macrophage scavenging of senescent polymorphonuclear cells undergoing apoptosis.  GP IV binds cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG).  Since thrombospondins are adhesive proteins widely distributed and involved in a variety of adhesive processes, GP IV may have important functions as a cell adhesion molecule.  (from OMIM 173510 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                
[17773] "The RALB gene encodes a GTP-binding protein related to RAS.  The human gene is located at 2cen-q13."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17774] "Human RALA Gene (RAS GTPase Family) at 7p15-p13 encodes 206-aa 24-kDa GTP-binding RAS-like RALA Protein, which interacts with RALBP1 via its effector domain and likely mediates some cell surface transmembrane receptor signaling. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17775] "Originally defined as a mouse tumor virus integration site, the PVT1 gene is involved in some human Burkitt lymphomas.  The human gene is located at 8q24."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17776] "Human NFKB2 Gene (Rel/Dorsal Family) encodes NF-Kappa B p49/p100, precursor of the NFKB p52 subunit containing seven ANK repeats that binds to p65REL proteins to form NFKB, trapped in the cytoplasm by IkB proteins. IkB phosphorylation by IKBKA or IKBKB activates NFKB via destructive ubiquitination of IkBs. Activated transcription factor NFKB translocates to the nucleus and binds to the consensus Kappa-B enhancer DNA motif in immune response and acute phase reaction genes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17777] "Human NMYC Gene (MYC family) at 2p24.1 overlaps with NCYM, trancribed from the opposite strand.  Two N-MYC Proteins originate from the same mRNA; both are phosphorylated, exceptionally unstable, located in the nucleus, and bind to single- and double-stranded DNA.  N-MYC is a likely heterodimeric bZIP transcription factor with MAX.  Efficient DNA binding of N-MYC requires dimerization with another bHLH protein. NMYC amplification is associated with oncogenic transformation.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17778] "The proto-oncogene FER (FPS/FES related), encodes a tyrosine kinase expressed in lymphoid cells; phosphoprotein NCP94. Inhibition of CDH2 (cytoplasmic domain) and beta-1 integrin function results in release of FER from the cadherin complex and accumulation in the integrin complex, suggesting that FER may mediate cross-talk between CDH2 and ITGB1.  The human gene is located at 15q26.1."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17779] "Human LMYC Gene (MYC family) at 1p34.3 encodes L-MYC Protein, a bZIP transcription factor that binds to DNA as a heterodimer with MAX; DNA binding requires dimerization with another bHLH protein.  The gene is amplified 10- to 20-fold in small-cell lung cancer (SCCL).  Several mRNAs are produced in SCCL cells from a single gene by alternative splicing and alternative polyadenylation signals. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17780] "Human Fibroblast Growth Factor 3 Gene (FGF family) at 11q13 contains three exons having a distinct pattern of expression throughout vertebrate development.  In mouse, FGF3 signals induction of the otic vesicle; rhombencephalic transcripts are detected when inner ear induction occurs.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17781] "The BMYB gene encodes a MYB family transcription factor essential during cell cycle progression.  MYBL2 transcripts are detectable in a wide variety of dividing cell types.  MYBL2 expression is regulated at the G1/S transition, and its transcription relies on E2F activity in a cell cycle-dependent manner.  MYBL2 activates CDC2 and cyclin D1 gene expression in proliferating fibroblasts.  The human gene is located at 20q13.1."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17782] "Expressed mainly in testis and peripheral leukocytes, human AMYB Gene (MYB family) at 8q22 encodes A-MYB Protein and may have a role in proliferation or differentiation of neurogenic, spermatogenic, and B-lymphoid cells.  In addition to three MYB-like domains, a DNA-binding domain, and a transcriptional activation domain, A-MYB contains two negative regulatory domains.  A-MYB specifically recognizes the sequence 5 prime-NAAC(G/T)G-3 prime.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17783] "The 17 kb human MPL Gene (HPOR family) at 1p34 encodes Thrombopoietin Receptor, a type I membrane protein with two fibronectin type III-like domains and member of the cytokine receptor superfamily.  TPO activates TPOR by inducing homodimerization and regulates production of a common progenitor of all myeloid lineages.  This progenitor expresses MPL, not IL7R; lymphoid progenitor expresses IL7R, not MPL.  Further differentiation of the myeloid progenitor depends on erythropoietin.  Defects in MPL cause congenital amegakaryocytic thrombocytopenia. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                           
[17784] "Distal to VWF, human Fibroblast Growth Factor 6 Gene (FGF family) at 12p13 encodes a product that exhibits strong mitogenic/angiogenic properties likely expressed by cells with platelet/megakaryocytic differentiation potential. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17785] "The Forkhead (Drosophila)-like 1 oncogene (FOXG1B) is a member of a large FKH/HNF3 family of transcription factors that share a unique highly conserved DNA-binding domain, the FKH box.  FOXG1B expression is restricted to telencephalic neurons.  The protein appears to act as a transcriptional repressor.  The human gene is located at 14q13."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17786] "Expressed in lung, placenta, liver, kidney, heart and brain, human FLT1 Gene (CSF1R/PDGFR family) at 13q12 encodes VEGF Receptor 1, a high-affinity VEGF- and PLGF-binding type I membrane receptor tyrosine kinase important for control of cell proliferation and differentiation.  Related to ROS, FLT1 is essential for organization of the embryonic vasculature, but not for endothelial differentiation.  FLT gene structure resembles FMS.  FLT1 and FLT3, lying head-to-tail within CpG islands, are separated by about 150 kb containing a putative receptor tyrosine kinase gene.  FLT1 contains seven C2-type Ig-like domains; domains 2 and 3 mediate VEGF binding.  An alternative soluble gene product, sFLT1, binds VEGF with higher affinity than the VEGF receptor FLK1.  sFLT1 and FLK1 form heterodimers and sFLT1 may function as an inhibitor of the VEGF response.  (from SWISS-PROT, OMIM, and NCI)"                                                                        
[17787] "Human FOSL1 Gene (FOS family) at 11q13 encodes FOSL1 Protein, a transcription factor lacking transactivation domains that dimerizes with JUN family members to form AP1 transcription factor.  Osteoclast differentiation from hematopoietic precursors of the monocyte-macrophage lineage is induced by RANKL stimulation of FOSL1 transcription in a FOS-dependent manner.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17788] "Widely expressed human MAFG Gene (MAF family) at 17q25 contains at least three exons separated by small introns and an untranslated first exon. Highest expression of the encoded bZIP transcription factor appears in skeletal muscle.  Lacking a transactivation domain, MAFs seem to be homodimerized repressors and heterodimerized activators with other bZIP proteins.  MAFG Protein heterodimerizes with NFE2/CNC Family members: NRF1, NRF2 and p45NFE2.  NFE2 enhancers upstream of alpha- and beta-globin genes regulate globin expression and erythroid differentiation through DNA-binding of a heterodimeric MAF protein (MAFF, MAFG, or MAFK) complexed with tissue-restricted p45NFE2.  MAF proteins also heterodimerize with FOS and may repress NFE2 as well.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                   
[17789] "Human MAF Gene (MAF family) at 16q22-q23 is a homologue of v-maf from avian musculoaponeurotic fibrosarcoma virus AS42.  Important in regulation of differentiation, MAF genes are a unique subclass of bZIP transcription factors.  Lacking a transactivation domain, MAFs seem to be homodimerized repressors and heterodimerized activators with other bZIP proteins.  MAF Protein contains a leucine zipper similar to many DNA-binding proteins.  (from OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17790] "Human FOSL2 Gene (FOS family) at 2p23-p22 encodes FOSL2 Protein, a transcription factor that dimerizes with JUN family proteins to form AP1 transcription factor.  FOSL2 appears to regulate cell proliferation, differentiation, and transformation.  In some cases, expression of this gene is associated with apoptotic cell death.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17791] "Human FYN Gene (SRC family) at 6q21 encodes a 2.8 kb mRNA expressed in various cell types that produces p59FYN Protein and controls mature thymocyte proliferation.  Containing an SH2 and SH3 domain, FYN interacts with FYN-binding protein and associates, through its SH3 domain, with the p85 subunit of PI3 kinase.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17792] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17793] "The Tumor-Associated Calcium Signal Transducer 1 gene encodes a 40 kD transmembrane glycoprotein originally identified as a marker of rapidly proliferating tumors of epithelial origin.  TACSTD1 is a ligand for LAIR1, and also binds LAIR2.  TACSTD1 interacts with the LAIRs through its first EGF-like repeat.  Through its interaction with the LAIR1 inhibitory receptor, TACSTD1 may be involved in preventing excessive inflammatory responses in regions, such as intestine, with high antigen exposure.  The human gene is located at 4q."                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17794] "Human GLI2 Gene (GLI/Kr family) at 2q14 encodes GLI2 Protein, a homologue of Ci (Drosophila).  Alpha, beta, gamma, and delta isoforms are produced by alternative splicing.  Containing five DNA-binding C2H2 zinc finger repeats, GLI2 binds to 5 prime-GAACCACCCA-3 prime DNA and activates transcription of SHH signaling gene targets.  Mutations in GLI genes may involve foregut developmental malformations and development of BCC.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17795] "Human LYN Gene (SRC family) at 8q13-qter encodes p53/56LYN, containing an SH2 and SH3 domain and similar to SRC protein tyrosine kinases in the catalytic domain.  LYNA and LYNB isoforms are produced by alternative splicing.  A 3.2 kb mRNA is expressed in fetal tissues different from related genes, such as YES.  LYN appears to play a role in FCER signaling and in Ig-mediated signaling, particularly in B-cell tolerance.  LYN is essential in ITIM-dependent signaling and for activation of protein tyrosine phosphatases in myeloid cells.  Disruptions of LYN display abnormalities in B-lymphocyte lineage and mast cell function.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                              
[17796] "Human LTA Gene (TNF family) at 6p21.3 encodes TNF Beta, a glycoprotein cytokine of activated lymphocytes having cytotoxic and necrotic effects.  Between C4 and HLA-B in the MHC region, TNFC resides just centromeric to TNFA, which is just centromeric to TNFB.  These three similar genes lie about 200 kb from HLA-B.  TNFC transcribes telomerically, TNFB and TNFA centromerically.  MHC polymorphic microsatellites within a 12 kb region include TNFB.  A putative immune response modulator similar to TNF Alpha, homotrimeric TNF Beta shares TNFR-1 and -2 receptors with TNF Alpha.  Involved in immunologic cell-cell contact reactions as well, TNFB associates in a heterotrimeric complex with a 33 kD TNFC type II membrane glycoprotein anchor on activated T, B, and LAK cells.  Composed of one TNFB and two TNFC subunits, the complex binds to TNFR-Related Protein, rather than TNFR-1 or -2.  (from SWISS-PROT, OMIM, and NCI)"                                            
[17797] "Human LTB Gene (TNF family) at 6p21.3 encodes TNFC, a 33 kD type II membrane glycoprotein with homology to TNF Alpha, TNF Beta, and CD40 ligand.  Between C4 and HLA-B in the MHC region, TNFC resides just centromeric to TNFA, which is just centromeric to TNFB.  These three similar genes lie about 200 kb from HLA-B.  TNFC is flanked by B144 and 1C7 on one side and by IKBL and BAT1 on the other.  TNFC transcribes telomerically, TNFB and TNFA centromerically.  Two isoforms are produced by alternative splicing.  Involved in immunologic cell-cell contact reactions, TNFC associates as a membrane anchor in a heterotrimeric complex with TNFB on activated T, B, and LAK cells.  Composed of one TNFB and two TNFC subunits, the complex binds to TNFR-Related Protein.  A homotrimeric TNFC has not been identified.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                         
[17798] "Related to GRO1 and GRO3, human GRO2 Gene (CXC family) at 4q12-q13 encodes CXC chemokine MIP-2 Alpha, a homologue of murine MIP-2, a chemotactic agent for polymorphonuclear leukocytes.  These genes exhibit regulation by inducing agents and tissue-specific regulation.  Produced by activated monocytes and neutrophils at inflammation sites, GRO2 is regulated by IL1, TNF, and lipopolysaccharide.  It consists of four exons and a 3-prime terminal 700 base pair untranslated region where significant differences are found among GRO genes, including numbers of ATTTA repeats associated with mRNA stability.  Proline substitution in GRO1 by leucine in GRO2 and GRO3 leads to a large predicted change in protein conformation.  Acting through a G protein coupled receptor, MIP-2 Alpha affects the central nervous system and endothelial cells involved in angiogenesis or angiostasis.  (from SWISS-PROT, OMIM, and NCI)"                                                      
[17799] "Related to GRO1 and GRO2, human GRO3 Gene (CXC family) at 4q12-q13 encodes CXC chemokine MIP-2 Beta, a homologue of murine MIP-2, a chemotactic agent for polymorphonuclear leukocytes.  These genes exhibit regulation by specific inducing agents and tissue-specific regulation.  Significant differences are found in the 3-prime untranslated region, including numbers of ATTTA repeats associated with mRNA stability.  Proline substitution in GRO1 by leucine in GRO2 and GRO3 leads to a large predicted change in protein conformation.  Acting through a G protein coupled receptor, MIP-2 beta may play a role in inflammation, exert autocrine angiogenic or angiostatic effects on endothelial cells, and affect the central nervous system.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                      
[17800] "Located about 27 kb proximal to PDE4C, human JUND Gene (JUN family) at 19p13.1-p12 is a metastasis suppressor gene that contains no introns and encodes JUND Protein, a bZIP DNA-binding transcription factor.  The most broadly expressed JUN family member of the AP1 transcription factor complex, JUND Protein binds the AP1 site as a dimer to stimulate promoter activity and may protect cells from senescence, or apoptotic responses to stress, by acting as a modulator of the signaling pathways that link RAS to p53.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                
[17801] "Human JUNB Gene (JUN family) at 19p13.2 encodes JUNB Protein, a bZIP transcription factor that binds to TGAC/GTCA DNA as a homodimer or heterodimer with other JUN/FOS family members, constituting the AP1 transcription factor complex.  JUNB regulates gene activity in the primary response to growth factors.  JUN and JUNB appear to have antagonistic functions; JUNB restores the expression of genes regulated by JUN/FOS, but not those regulated by JUN/ATF.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17802] "Member of a gene family active in B-cell proliferation and differentiation, human IRF4 Gene (MUM/IRF family) at 6p25-p23 encodes Interferon Regulatory Factor 4, a transcription factor that binds interferon-stimulated response elements of the MHC class I promoter.  It is induced after TCR activation in T-cells.  A 5 kb transcript is expressed in spleen, lymphocytes, and melanocytes.  Two isoforms differing by one glutamate residue are produced by alternative splicing.  IRF4 also binds with PU.1 to the Ig lambda light chain enhancer.  IRF4 may participate in lymphoid cell ISRE-targeted signal transduction. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                               
[17803] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17804] "The 9.5 kb human HKR3 Gene (Kr family) at 1p36.3 encodes HKR3 Protein, a 77 kD DNA-binding protein with eleven C2H2 zinc fingers separated by H/C links, an N-terminal tramtrack-associated box (BTB/POZ domain), and an acidic activation domain.  About 40 kb from D1S214, HKR3 contains a 5-prime CpG island and eleven exons.  Widely expressed 2.3 and 1.4 kb splice variants are observed; the smaller lacks TAB and activation domains.  HKR3 appears to bind to, and regulate, J or S elements in the MHC II promoter.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17805] "Human HCK Gene (SRC family) at 20q11-q12 appears to encode p59/60HCK, a membrane-associated tyrosine kinase that contains an SH2 and SH3 domain. HCK is expressed primarily in hematopoietic cells, especially of myeloid lineage and particularly in mature granulocytes and monocytes.  Two isoforms, p60HCK and p59HCK, are produced by alternative initiation.  HCK may couple the Fc receptor to activation of the respiratory burst.  It may also contribute to neutrophil migration and may regulate neutrophil degranulation.  HCK deletions may contribute to AML and myeloproliferative disorders.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                     
[17806] "Topoisomerase II catalyzes relaxation of supercoiled DNA molecules, catenation, decatenation, knotting, and unknotting of circular DNA.  The topoisomerase II reaction appears to involve crossing-over of two DNA segments.  Human cells contain two topoisomerase II isozymes: alpha and beta from distinct genes.  DNA topoisomerase II alpha is associated with the Pol II holoenzyme and is required for chromatin-dependent co-activation.  Transcription results in superhelical tension; topoisomerase II relaxation activity is essential for productive RNA synthesis on nucleosomal DNA.  (from OMIM 126430 and NCI)"                                                                                                                                                                                                                                                                                                                                                                    
[17807] "A secreted form of erbB2 that may have utility as a tumor marker."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17808] "A secreted form of erbB1 that may have utility as a tumor marker."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17809] "Classification.  Proto-oncogenes that code for G proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17810] "Classification.  Proto-oncogenes that code for growth factors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17811] "Classification.  Proto-oncogenes that code for products that are localized in the nucleus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17812] "Classification.  Proto-oncogenes that code for transcription factors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17813] "Classification.  Proto-oncogenes that code for protein kinases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17814] "Classification.  Proto-oncogenes that code for products with protein tyrosine kinase activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17815] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17816] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17817] "Oncogene MAS encodes a novel G protein coupled receptor that was originally identified as a transforming protein when over expressed in NIH 3T3 cells. MAS has greatest sequence similarity to the substance K receptor and may encode a peptide receptor with mitogenic activity that acts through inositol lipid signaling pathways. MAS may be a receptor in a growth-regulating pathway; it seems to be involved in some aspect of angiotensin signaling. The human gene is located at 6q24-q27."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17818] "Human ELK3 Gene (ETS Family) at 12q23 encodes ELK3 Protein, a DNA-binding transcription factor highly expressed at early stages of B-lymphocyte development.  Expression of the 2.5 and 4.5 kb mRNAs declines upon B-cell maturation and correlates with Ig heavy chain enhancer activity.  ELK3 may play a role in B-cell development and immunoglobulin gene regulation.  ELK3 may be a negative transcription regulator, but can activate transcription when co-expressed with RAS, SRC or MOS.  ELK3 interacts with CTBP1 and can form ternary complexes with serum response factor on the ETS and SRF motifs of the FOS gene serum response element.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                        
[17819] "The human ST5 gene is expressed as 4.6, 3.1 and 2.8 kb transcripts encoding putative 126, 82 and 70 kDa proteins that function in the MAP kinase signaling pathway in transient expression assays."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17820] "SPINK1 encodes serine protease inhibitor, Kazal type 1. The gene product is secreted from pancreatic acinar cells into pancreatic juice and is thought to prevent trypsin-catalyzed premature activation of pancreatic zymogens.  It is also found in serum and various normal tissues; SPINK1 is produced by gastrointestinal tract mucosa where it may protect mucosal cells from proteolytic breakdown.  (from OMIM 167790 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17821] "The SKI oncogene was originally isolated from Sloan-Kettering viruses (SKVs), a group of replication-defective transforming retroviruses.  The c-SKI proto-oncogene encodes a transcriptional repressor that homo- and heterodimerizes with the related protein, snoN.  SMAD3 associates with nuclear SKI protein in response to TGFB1 signaling, repressing transcriptional activation by SMAD3, and rendering cells resistant to the growth-inhibitory effects of TGFB.  The effects of SKI can be overcome by increased expression of SMAD3.  The human gene is located at 1q22-q24."                                                                                                                                                                                                                                                                                                                                                                                                            
[17822] "Oncogene ETS was originally discovered as a chimeric component, along with a truncated v-myb gene, in the genome of E26, an avian leukosis virus. ETS1 encodes 42-52 kD nuclear phosphoprotein transcription factors that interact with purine-rich promoter/enhancer sequences in the TCRA gene. ETS1 also regulates p16(INK4A) gene expression. The human gene is located at 11q23.3."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17823] "Human ABL2 Gene (ABL family) at 1q24-q25 produces a 12 kb transcript that encodes a widely expressed cytoplasmic tyrosine kinase with SH2 and SH3 domains.  Isoforms IA and IB are produced by alternative splicing.  ABL2 is fused with ETV6 in AML translocation t(1;12)(q25;p13) and is also involved in CML.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17824] "The 200-250 kb human GLI3 Gene (GLI/Kr family) at 7p13 encodes GLI3 Protein, a DNA-binding C2H2 zinc finger transcription factor likely required in limb and brain development.  Containing a 5-prime CpG island, two intragenic dinucleotide repeats, and fourteen exons, the gene expresses an 8.5 kb mRNA in lung, colon, spleen, placenta, testis, and myometrium.  Transactivating domains reside in the C-terminus, a DNA-binding domain lies in the central region.  GLI3 functionally mirrors its homologue, Ci (Drosophila).  In response to hedgehog, activator Ci is cleaved to a repressor.  GLI3 regulates PTCH and mediates SHH signal transduction.  In vertebrate limb development, PKA-dependent processing of GLI3 generates a repressor, antagonized by sonic hedgehog signaling.  GLI3 mutations may be responsible for Pallister-Hall Syndrome, Greig Cephalopolysyndactyly Syndrome, and Postaxial Polydactyly.  (from SWISS-PROT, OMIM, and NCI)"                            
[17825] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17826] "Human EMP1 Gene (PMP-22/EMP/MP20 Family) at 12p12.3 contains five exons that encode Epithelial Membrane Protein-1, an integral membrane protein containing four transmembrane domains likely involved in cell-cell interactions and control of cell proliferation.  EMP1 expression is seen in embryonic kidney, brain, and gut, but not in liver and thymus.  A 2.8 kb EMP1 transcript is found in most adult tissues, but not in brain, liver, pancreas, or peripheral leukocytes.  EMP1 is highly expressed in brain tumor cells. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                              
[17827] "The BCR Gene at 22q11.21 encodes a cytoplasmic phosphoprotein with unique serine/threonine kinase activity and contains twenty-three exons with an unusual inverted repeat flanking the first exon. It is expressed as mRNAs of 4.5 and 6.7 kb, which encode the same 160 kD protein. The gene is oriented 5-prime centromeric. BCR is located at the breakpoints of Philadelphia chromosome translocations that join to the ABL gene found in CML, AML, and ALL. BCR Protein promotes the activating exchange of GTP for GDP bound by p21 or CDC42. The region of BCR involved in binding to the ABL SH2 domain is rich in serine residues and must be serine/threonine phosphorylated prior to SH2 binding. This region is essential for activation of ABL tyrosine kinase. BCR is autophosphorylated and contains a DBL, a PH, a C2, and a GAP domain. (from SWISS-PROT, OMIM, and NCI)"                                                                                                         
[17828] "A measure of the percentage of cells in a tumor that are in the phase of the cell cycle during which DNA is synthesized. The S-phase fraction may be used with the proliferative index to give a more complete understanding of how fast a tumor is growing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17829] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17830] "The THPO oncogene encodes thrombopoietin, a lineage-restricted glycoprotein growth factor with stimulatory effects on megakaryopoiesis and platelet production.  The human gene is located at 3q26.3-q27."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17831] "Expressed in many tissues, the 80 kb human KAI1 Gene (TM4SF family) at 11p11.2 contains ten exons that specify metastasis suppressor KAI1 Protein, with four putative transmembrane domains and a large extracellular domain having three potential N-glycosylation sites.  KAI1 appears to be up regulated in activated T-cells.  p53 activates the gene by interacting with sequences in a 5-prime upstream region.  Loss of p53 appears to cause down regulation of KAI1.  Similar to leukocyte cell surface glycoproteins involved in cell adhesion and signal transduction, KAI1 is a likely homologue of mouse leukocyte surface antigen R2, similar to CD37 and CD53.  Associated with CD4 or CD8, KAI1 delivers co-stimulatory signals for the TCR/CD3 pathway.  KAI1 expression at the transcription or posttranscription level is often down regulated during tumor progression. (from SWISS-PROT, OMIM, and NCI)"                                                                        
[17832] "Human GRO1 Gene (CXC family) at 4q12-q13 encodes mitogenic polypeptide Melanoma Growth Stimulating Activity.  Related to platelet derived beta-thromboglobulin and acting through a G protein coupled receptor, chemokine MGSA-alpha belongs to a family that includes pro-inflammatory IL8 and PF4.  Chemotactic for polymorphonuclear leukocytes, GRO1 may play a role in inflammation.  Macrophages secrete GRO1 in response to endotoxin. GRO1 also affects endothelial cells involved in angiogenesis or angiostasis in an autocrine fashion and affects the central nervous system as well.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                
[17833] "Human ELK1 Gene (ETS Family) at Xp11.2 encodes ELK1 Protein, a putative DNA-binding transcription factor active in testis and lung.  Two isoforms are produced by alternative splicing.  ELK1 binds to purine-rich DNA; it can form a ternary complex with serum response factor on the ETS and SRF motifs of the FOS gene serum response element.  ELK1 is phosphorylated by three MAP kinase groups (p38, JNK, and ERK).  ELK2 is a processed pseudogene of ELK1.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17834] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17835] "Human NKTR Gene at 3p23-p21 encodes Natural Killer Triggering Receptor, involved in the recognition of tumor cells by the LGL subpopulation of granular lymphocytes that kill tumor cells by an MHC-independent mechanism.  Attached to the surface of LGLs via its hydrophobic N-terminus followed by a cyclophilin-like PPIASE domain, the 150 kD gene product facilitates binding to tumor targets.  Alternative splicing occurs in the 5-prime region.  Use of an alternate exon 6 produces a truncated protein, while use of an alternate splice acceptor in exon 9 generates a deletion.  LGL activation by IL2 changes the splicing pattern to enhance production of a full-length protein. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                
[17836] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17837] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17838] "Encoded by Regulatory Genes, Regulatory Proteins regulate or circumscribe the activity of many cellular functions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17839] "Digital mammography assists in the early detection of breast cancer by incorporating modern electronics and computers into x-ray mammography methods. Instead of acquiring an image on film, it is collected electronically and can be stored directly into a computer.  Digital mammography is quick and has the potential to reduce patient anxiety and inconvenience. Moreover, digital mammograms are easily archived and electronically transferable, making them ideal for teaching purposes and for evaluation during long-distance telemedicine consultations."                                                                                                                                                                                                                                                                                                                                                                                                                             
[17840] "An artificial environment generated by a computer that simulates the actual (real) world.  Users can control VR programs through sensory loaded gloves and headsets, that are equipped with video monitors that give feeling of movement through 3-dimensional \"virtual\" environments."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17841] "interaction among or within protein domains which may alter the structure thus affecting the function of the protein or group of proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17842] "A field of chemistry concerned with the development of techniques for the collection and manipulation of chemical data, and the use of such data to make chemical discoveries or predictions. This field encompasses computer-based techniques for solving chemical problems including manipulation of models and datasets."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17843] "Interdisciplinary clinical, epidemiologic, genetic, and laboratory studies of persons, families, and populations at high risk of cancer. These investigations identify genes and exposures conferring cancer predisposition, and explore the combined effects of predisposition and specific exposures. (from DCEG homepage)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17844] "Use of robots and other automated techniques to screen large numbers of samples."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17845] "Molecular biology techniques, including Northern Blot, Differential display, RT-PCR, and RNase protection for qualifying or quantifying RNA. (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17846] "Proteins found in any species of yeast."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17847] "simultaneously perform liquid chromatography techniques tandem to different mass spectrometry techniques."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17848] "Populations that do not have adequate access to medical care. This includes rural, elderly, low-literacy, blue collar, and poor populations. Minorities per se are not included but often belong to one or more or the included categories."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17849] "A microscopic, ordered array of nucleic acids, proteins, small molecules, cells or other substances that enables parallel analysis of complex biochemical samples. (From Mark Schena et al. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270, 467-470 Oct. 20 1995)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17850] "science involved with manufacturing or engineering one atom or molecule at a time with precise atomic specifications; concerned with materials and systems whose structures and components exhibit novel and significantly improved physical, chemical and biological properties, phenomena and processes because of their small nanoscale size; includes technology to generate and use nanostructures and nanodevices; do not index on projects simply observing and describing physical characteristics at the nanoscale level."                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17851] "morphological and other aspects of diseases of the nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17852] "Serial analysis of gene expression (SAGE) is novel method of assessing the variation in the type or amount of genes expressed in different tissues, at different times in development or in normal versus malignant cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17853] "The MSH2 gene (MUTS family) at 2p22-p21 encodes DNA Mismatch Repair Protein MSH2, a postreplication mismatch repair homologue of mutS (E. coli), which binds to insertion-deletion looped DNA mismatches. MutS homologues have ATPase activity and contain a conserved DNA binding helix-turn-helix domain associated with an adenine nucleotide/magnesium-binding Walker-A motif that may regulate mismatch binding as a molecular switch. ADP-bound MSH2/MSH6 binds to mismatched DNA, provoking ADP/ATP exchange and MSH2/MSH6 migration along the DNA backbone. DNA-bound, ATP-bound MSH2/MSH6 activates the repair machinery. MSH2 is part of the multisubunit BASC complex, which may sense abnormal DNA structures and regulate postreplication repair. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. MSH2 alteration is associated with DNA instability. (From SWISS-PROT, OMIM, and NCI)"                                  
[17854] "The MLH1 gene (MUTL/HEXB family) at chromosome 3p21.3 is a mismatch repair gene that consists of nineteen coding exons with exons 1 to 7 contain a highly conserved region. Widely expressed, several alternative splice variants occur in diverse tissue types. Some variants lack exons 6/9, 9, 9/10, 9/10/11, 10/11, 12, 16, or 17. The encoded protein, MutL Homolog 1 (MLH1), is part of the multi-subunit BASC complex, which may sense abnormal DNA structures and regulate post-replication repair. Heterodimeric MLH1 Protein and PMS2 provide repair proficiency on heteroduplex DNAs, as well as insertion/deletion mispairs. MLH1 and MLH3 also heterodimerize. Associated with colon, endometrial, and stomach cancers, the defects in MLH1 are a cause of hereditary non-polyposis colorectal cancer. (NCI)"                                                                                                                                                                          
[17855] "Variation of the polymerase chain reaction used to identify differentially expressed genes.  mRNA from two different tissue samples is reverse transcribed, then amplified using short, intentionally nonspecific primers.  The array of bands obtained from a series of such amplifications is run on a high resolution gel, and the array of bands compared with analogous arrays from different samples.  Any bands unique to single samples are considered to be differentially expressed; they can be purified from the gel, and sequenced and used to clone the full-length cDNA.  Similar in result to subtractive hybridization. (DCB-CB)"                                                                                                                                                                                                                                                                                                                                                  
[17856] "Nuclear hormone receptors constitute a superfamily of structurally related ligand binding transcription factors that includes the steroid receptors, thyroid hormone receptors, vitamin D and retinoid receptors, and orphan receptors for which ligands have not yet been found."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17857] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17858] "Gene transfer between species. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17859] "A 70-kDa high-affinity cell surface receptor for tumor necrosis factor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17860] "Encoded by human TEK Gene (TIE Family) and expressed predominantly in endothelia and angioblasts, TEK Tyrosine Kinase receptor is a type I transmembrane protein closely related to the TIE receptor. With a unique extracellular domain containing 2 Ig-like C2 domains separated by 3 EGF-like domains connected to 3 FN III-like domains, the ANG1 and ANG2 receptor TEK is important in angiogenesis, endothelial cell proliferation and differentiation, and endothelial cell patterning during vascular morphogenesis. TEK may constitute a mammalian endothelial cell lineage marker. Activating defects and deficiencies in TEK are associated with venous malformations (VMCM). (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                               
[17861] "A dendritic cell-specific receptor for ICAM-3.  It can bind to HIV gp120, thereby transporting it to internal sites and facilitating trans infection of secondary lymphoid organs rich in T cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17862] "HER3/erbB3.  Member of the EGF receptor (erbB) family.  Receptor for NDF/heregulin (Neu differentiation factor); heterodimerizes with other type I receptor tyrosine kinases. It is overexpressed frequently in several common solid tumors, including in breast cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17863] "Cell cycle kinetics is the rate at which a cell progresses through the cell cycle.  It is a general indication of how fast a tissue or cell sample is proliferating.  This rate is generally increased in more aggressive tumors and can be measured by various biochemical methods such as the incorporation of labeled nucleotides into replicating DNA or the level of expression of cell cycle proteins or other proliferation markers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17864] "Encoded by Cyclin-Dependent Kinase Inhibitor Genes, Cyclin-Dependent Kinase Inhibitor Proteins are a group of low molecular weight proteins that associate with Cyclin/CDK complexes or CDKs alone, inhibiting their activity and regulating the cell cycle. (From OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17865] "RAEB: a characteristic that indicates the risk of developing a disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17866] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17867] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17868] "Protein phosphorylation is one of various post-translational protein modifications that regulates protein function and enzymatic activity.  The major phosphoryl acceptors in proteins are serine, threonine, and tyrosine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17869] "Tyrosine phosphorylation involves the introduction of a phosphoryl group into a compound through the formation of an ester bond between a tyrosine residue in the compound and a phosphorus moiety."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17870] "The CYP1A1 gene is a human lung cancer modifier gene and member of the cytochrome P450 gene family.  The CYP1A1 gene product is the form of P450 most closely associated with polycyclic-hydrocarbon-induced AHH activity.  The gene encodes a phase I cytochrome P450 enzyme that metabolizes PAHs (polycyclic aromatic hydrocarbons).  Individuals with a high-inducibility phenotype (gene expression in response to PAHs) may be at greater risk than low-inducibility individuals for cigarette smoke-induced bronchogenic carcinoma.  The human gene is located at 15q22-15q24."                                                                                                                                                                                                                                                                                                                                                                                                              
[17871] "THE CYP2E1 gene is a human lung cancer modifier gene and a member of the ethanol-inducible P450IIE subfamily of the cytochrome P450 gene family.  CYP2E is an important enzyme in the catalytic conversion of ethanol to acetaldehyde and acetate.  CYP2E is also involved in the metabolism of nitrosamines and encodes N-nitrosodimethylamine demethylase activity.  The human gene is located at 10q24.3-10qter."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17872] "A colon cancer modifier, Human MTHFR Gene (MTHFR family) at 1p36 is composed of eleven exons that encode methylene tetrahydrofolate reductase.  Exon sizes, location of intron boundaries, and intron sizes are similar between the human and mouse genes; amino acid sequences share nearly 90% identity.  Involved in folate metabolism, the homodimeric enzyme catalyzes, with cofactor FAD, the conversion of 5,10-methylene tetrahydrofolate to N(5)-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.  MTHFR enzyme is allosterically regulated by S-adenosylmethionine.  Defects in MTHFR cause homocysteinemia. (NCI)"                                                                                                                                                                                                                                                                                                                                   
[17873] "A lung cancer modifier and member of the NADPH Quinone Oxido-Reductase (NQO) family, the 10 kb human NQO1 Gene at 16q22.2 has four potential polyadenylation sites and encodes cytoplasmic Quinone Oxidoreductase, a two-electron homodimeric reductase that, with cofactor FAD, detoxifies quinones derived from the oxidation of phenolic metabolites of benzene.  Three transcripts appear to be differentially regulated.  Synthetic antioxidants and cruciferous vegetables are potent gene inducers.  Quinone oxidoreductase accepts electrons with equal efficiency from NADH and NADPH.  NQO1 also participates in the vitamin K-dependent gamma-carboxylation of glutamatyl residues in prothrombin synthesis.  Reduced NQO1 activity may promote vulnerability to leukemia secondary to chemical exposure.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                             
[17874] "The SRD5A2 gene is a human prostate cancer modifier gene that encodes a steroid 5-alpha-reductase enzyme.  The human gene is located at 2p23."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17875] "The VDR gene is a human prostate cancer modifier gene that encodes a vitamin D receptor.  Vitamin D3 receptors are intracellular polypeptides of 50-60 kD that specifically bind 1, 25(OH)2D3 and interact with target-cell nuclei to produce a variety of biologic effects.  VDR belongs to the superfamily of trans-acting transcriptional regulatory factors, including the steroid and thyroid hormone receptors.  VDR is more closely related to the thyroid hormone receptors than to the others.  The human gene is located at 12q12-12q14."                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17876] "The SMAD3 gene is a human homologue of Drosophila Mad and is required for the TGF beta signal transduction pathway.  MADH3 activity is regulated by TGF beta receptors.  MADH3 is phosphorylated and associates with ligand-bound receptor complex, defining MADH3 as an effector of the TGF beta response.  MADH3 and MADH4 synergize.  SMAD3 and SMAD4 proteins specifically recognize an eight base pair palindromic sequence, which confers TGF beta responsiveness to a minimal promoter.  The human gene is located at 15q21-q22."                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17877] "Variation between individuals in the number of repeat units of Simple Tandem Repeats at a specific location in the genome.  These are used extensively as markers in gene mapping and linkage analysis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17878] "A family of cellular proteins encoded by the c-erbB genes, including epidermal growth factor receptor. They are normally expressed in a variety of tissues of epithelial, mesenchymal, and neuronal origin.  They are overexpressed in a significant portion of adenocarcinomas found at various sites, especially in the breast. Gene amplification appears to be the predominant method leading to overexpression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17879] "Retrovirus-associated DNA sequences originally isolated from, or related to, the avian erythroblastosis virus (AEV). The c-erbA proto-oncogene encodes the thyroid hormone receptors, and the c-erbB family codes for the epidermal growth factor receptor (erbB-1, EGFR) and related receptors (erbB-2, erbB-3)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17880] "REL protein is a product of the REL proto-oncogene and may play a role in differentiation and lymphopoiesis.  It belongs to the REL/Dorsal family of transcription factors, containing the REL Homology Region (RHR), that includes NFKB and NF-AT.  Some members of this family are regulated by subcellular sequestration in the cytoplasm by members of the IKB protein subfamily of RHR proteins, and are involved in embryonic development and differentiation.  (from OMIM 164910 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17881] "EPH tyrosine kinase 1 is a member of the largest subfamily of RTKs. EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. EPH-family receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and two fibronectin type III repeats. EPH receptors are divided into two groups based on their extracellular domain sequences and affinities for ephrin-A (EPHA) and ephrin-B ligands (EPHB).  Ephrin-A2 forms a stable complex with the metalloproteinase Kuzbanian, involving interactions outside the cleavage region and the protease domain.  EPH tyrosine kinase 1 receptor binding triggers ephrin-A2 cleavage in a localized reaction specific to the cognate ligand. (from OMIM 179610 and NCI)"                                                                                                                                                                                 
[17882] "Expressed in hematopoietic cells, human NOV Gene (CCN family) at 8q24.1 appears to encode Insulin-Like Growth Factor-Binding Protein-9, a cysteine-rich growth regulation immediate-early protein expressed after growth factor induction.  Mouse, human, and chick NOV genes are highly conserved in sequence and organization; the conserved exon structure reflects a modular organization of the protein, as does the distribution of its forty cysteine residues.  CCN proteins control cell proliferation and share several motifs: an IGFBP motif, an oligomeric complex-forming domain, a binding domain for soluble and matrix molecules, and a CT dimerization domain.  NOV protein contains one VWFC domain and a C-terminal cystine knot-like domain.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                
[17883] "Cloned by homology to the mouse DAN gene. In mouse, the DAN gene possesses a tumor suppressive activity when it is overexpressed in v-src transformed cells. One human study excluded DAN as a tumor suppressor in neuroblastoma through loss of heterozygosity studies. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17884] "The BCL1 proto-oncogene is activated by chromosome translocation in human B-cell lymphomas. The chromosomal breakpoint in chronic lymphocytic leukemia cells, t(11;14)(q13;q32), involves the Ig heavy chain J4 segment on chromosome 14. The gene located on 11q13 in the t(11;14) translocation is referred to as BCL-1. Some evidence indicates that the PRAD1 gene on 11q13 may be the BCL1 oncogene. PRAD1 encodes cyclin D1, essential for cell cycle control at the G1/S transition.  The human gene is located at 11q13."                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17885] "An evaluation of the size and shape of the nucleus in tumor cells and the percentage of tumor cells that are in the process of dividing or growing. Cancers with low nuclear grade grow and spread less quickly than cancers with high nuclear grade."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17886] "Human Maspin Gene (Serpin family) at 18q21.3 encodes Maspin in a single 3 kb mRNA, which blocks growth, invasion, and metastasis of mammary tumors.  In the 300 kb telomere-centromere cluster of PAI2-SCCA1-SCCA2-PI5 serine proteinase inhibitor genes, SCCA1 and SCCA2 transcribe centromerically, opposite to PAI2 and PI5.  Maspin does not undergo serpin conformational transitions and exhibits no serine protease inhibitory activity, but plays a role in cell-matrix adhesion, tumor invasion, and metastasis.  High maspin expression appears to oppose lymph node metastasis.  Higher expression is associated with better survival rates and may be a favorable prognostic marker.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                 
[17887] "Proteins or peptides that participate in signal transduction processes in the cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17888] "Homologue of the v-fms McDonough feline sarcoma oncogene, proto-oncogene CSF1R encodes the macrophage colony-stimulating factor 1 receptor tyrosine kinase.  Myelomonocytic cytokine receptors for macrophage colony-stimulating factor are expressed at low to moderate levels on primitive hematopoietic stem cells, absent on common lymphoid progenitors, and up regulated after myeloid lineage induction by IL2.  CSF signaling can regulate cell fate decisions, and down regulation of cytokine receptors that drive myeloid cell development may be a critical step in lymphoid commitment.  The human gene is located at 5q33.2-q33.3."                                                                                                                                                                                                                                                                                                                                                   
[17889] "The result of a t(12;21) translocation, TEL-AML1 Oncogene encodes a fusion protein containing the helix-loop-helix domain of TEL, a member of the ETS-like family of transcription factors, and the DNA-binding and transactivation domains of the transcription factor AML1. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17891] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17892] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17893] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17894] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17895] "The RAD gene encodes a 29 kD member of the RAS-guanosine triphosphatase superfamily that is associated with insulin resistance in type II diabetes mellitus.  Selectively over expressed in type II diabetic muscle, the RAD gene is normally expressed primarily in skeletal and cardiac muscle.  The human gene is located at 16q22."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17896] "Chromosomal fragile sites may be hotspots for chromosome rearrangements.  Containing the FRA3B fragile site, the FHIT gene is a target of homologous recombination between LINE sequences that result in internal gene deletions, probably due to carcinogenic damage at FRA3B sites.  FHIT, a putative tumor suppressor gene and member of the histidine triad family, encodes AP3A hydrolase.  AP3A, and AP4A, may regulate DNA replication and signal stress responses.  The conserved histidine triad residues are required for enzymatic activity.  The human gene is located at 3p14.2."                                                                                                                                                                                                                                                                                                                                                                                                      
[17897] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17898] "A transcription cofactor that activates transcription from a RNA polymerase II promoter but does not bind DNA itself."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17899] "Transcription Repressor/Corepressor Gene encodes Transcriptional Repressor/Corepressor, proteins that can regulate transcription by binding to the operator and causing repression. (from Glick: Glossary of Biochemistry and Molecular Biology)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17900] "TIM encodes a 60 kD protein containing a Dbl-homology domain, which is shared by several signal transducing molecules implicated as regulators of small GTP-binding proteins. TIM is thought to be involved in control of cytoskeletal organization through regulation of small GTP-binding proteins.  (from OMIM 600888 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17901] "GLI Family Genes encode DNA-binding GLI Family Proteins containing zinc finger repeats and involved in pattern formation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17902] "FOSL1 protein is a possible heterodimeric nuclear protein that lacks transactivation domains and belongs to the bZIP family.  Transcription of FOSL1 is induced in osteoclast differentiation by RANKL, in a FOS-dependent manner.  (from SWISS-PROT P15407, OMIM 136515, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17903] "A possible nuclear hetero-dimeric protein that belongs to the bZIP family.  FOSL2 protein can dimerize with JUN family proteins to form the transcription factor AP-1 complex and is a possible regulator of cell proliferation, differentiation, and transformation.  (from SWISS-PROT P15408, OMIM 601575, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17904] "About 35 kb downstream of INT2 and in the same orientation, human Fibroblast Growth Factor 4 Gene (FGF family) at 11q13 encodes a heparin-binding growth factor with homology to basic and acidic FGF, and to mouse Int2 protein.  Gremlin relays a SHH signal from the polarizing region to the apical ectodermal ridge.  Formin-dependent activation of BMP-antagonist Gremlin induces FGF4 and the SHH/FGF4 feedback loop.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17905] "ABL2 tyrosine kinase is related to ABL.  A case of acute myeloid leukemia M4 carrying the t(1;12)(q25;p13) translocation involves a fusion between ETV6 and ABL2, resulting in a chimeric protein consisting of the HLH oligomerization domain of ETV6 and the SH2, SH3, and protein tyrosine kinase domains of ABL2.  (from OMIM 164690 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17906] "Encoded by JUN Family Genes, nuclear leucine zipper JUN Family Proteins (JUN, JUNB, and JUND) can homodimerize, or heterodimerize with nuclear leucine zipper FOS Family Proteins, to form the specific promoter/enhancer DNA-binding AP-1 transcription factor complex that regulates target gene transcription in cell proliferation, differentiation, and transformation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17907] "Encoded by human ARAF1 Gene (MIL/RAF Family), cytoplasmic A-RAF [serine/threonine] Protein Kinase contains a DAG binding and a RBD domain, and is involved in transduction of mitogenic signals from cell membrane to nucleus. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17909] "MYC Family Genes encode MYC Family Proteins, class III bHLH leucine zipper transcription factors having cellular proliferative and apoptotic roles. Dimerization via leucine zippers of MYC proteins with bHLH/lz proteins, such as MAX, is required for efficient DNA binding. Leucine zippers are present in many gene regulatory proteins, including CREB proteins, Jun/AP1 transcription factors, and FOS-type proteins, as well as MYC proteins. The periodically repeated leucine side chains extending from one alpha helix interdigitate with leucine residues of another alpha helix, facilitating coiled-coil dimerization; like charge repulsion in this region perturbs homodimer formation; heterodimers are promoted by opposing charge attractions. c-MYC transcription factor binds to CAC(GA)TG DNA sites. MYC sequences have been highly conserved throughout evolution, from Drosophila to vertebrates. (NCI)"                                                                   
[17910] "MYC family proteins exhibit sequence homolgy with the transcription factor MYC protooncogene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17911] "A member of the cadherin superfamily; plays a crucial role in neural crest development."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17912] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17913] "The LCK Gene at 1p35-p34.3 encodes p56LCK, a lymphocyte-specific tyrosine protein kinase with an SH2 and SH3 domain. LCK may participate in T-cell activation. It binds to the cytoplasmic domain of CD4, CD8, and the IL-2R beta chain. p56LCK is quickly activated by mIg cross-linking on B-cells or by TCR cross-linking. Pre-TCR co-localizes with p56LCK kinase in membrane rafts resulting in phosphorylation of CD3-epsilon and ZAP70. p56LCK, in the TCR complex, activates DNA binding of STAT5A and STAT5B. p56LCK regulates the allelic exclusion pathway at the TCR beta locus. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                      
[17914] "Human FGR Gene (SRC Family) at 1p36.2-p36.1 encodes 529-aa 59.5-kDa p55-FGR, a protein tyrosine kinase containing 1 SH2 and 1 SH3 domain that may bind PTPNS1. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17915] "Human YES1 Gene (SRC Family) encodes 543-aa 61-kDa tyrosine kinase p61-YES, containing an SH2 and an SH3 domain. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17916] "Expressed in placenta by human TACSTD2 Gene (GA733 Family), 323-aa 36-kDa (precursor) type I membrane protein Tumor-Associated Calcium Signal Transducer 2 contains 1 Thyroglobulin Type-I domain, acts as a cell surface receptor, and transduces an intracellular calcium signal. The N-terminus is blocked. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17917] "MAF proteins have been reported to be able to bind with FOS proteins to form the AP-1 transcription factor (from Nature Cell Biol. 4: E131-E136, 2002 via OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17918] "MAF proteins have been reported to be able to bind with FOS proteins to form the AP-1 transcription factor (from Nature Cell Biol. 4: E131-E136, 2002 via OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17919] "The cellular homologue of v-cbl, CBL protein is expressed in a range of hemopoietic lineages.  Malignancies are associated with translocations of the CBL gene.  Adaptor protein CBL2, containing a RING finger and multiple SH3 domains, encodes a protein similar to SLI1, a negative regulator of an EGF receptor tyrosine kinase homologue.  Through its SH2 domain, CBL regulates activated tyrosine-phosphorylated receptor PTK ubiquitination as an E3 ubiquitin ligase and recruits, and activates, an E2 ubiquitin-conjugating enzyme through its RING domain.  CBL is recruited to the tyrosine kinase insulin receptor by CAP adaptor protein, through a CAP SH3 domain.  Upon CBL phosphorylation, CAP/CBL dissociates from the receptor to complex with caveolar flotillin and localize to plasma membrane lipid rafts.  (from OMIM 165360 and NCI)"                                                                                                                                   
[17920] "Ntrk1/Tropomyosin chimeric protein is encoded by the TRK gene, formed by a somatic rearrangement involving the neighboring genes for Neurotrophic Tyrosine Kinase Receptor type 1 and nonmuscle Tropomyosin.  Replacement of the receptor extracellular domain by nonmuscle Tropomyosin residues leads to transformation by the chimeric TRK oncogene product.  (from OMIM 164970 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17922] "NF-Kappa B p49/p100 is the precursor of the NFKB p52 subunit. NFKB2 belongs to the Rel/Dorsal family, contains seven ANK repeats, and binds to REL (p65) proteins to form NFKB, which is trapped in the cytoplasm by IkB proteins. IkB phosphorylation by IKBKA or IKBKB activates NFKB via destructive ubiquitination of IkBs. Activated transcription factor NFKB translocates to the nucleus and binds to the consensus Kappa-B enhancer DNA motif in immune response and acute phase reaction genes. (from SWISS-PROT Q00653, OMIM 164012, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17923] "The human NTRK1 Gene (INSR family) at 1q21-q22 encodes a type I membrane tyrosine protein kinase receptor for NGF and other neurotrophins. This gene lacks a TATA box, but has putative binding sites for Sp1, AP1, AP2, AP3, ATF, and GCF. Exon 9 is alternatively spliced. The TRKA-I and TRKA-II isoforms have similar biological properties. TRKA-II is primarily expressed in neurons but TRKA-I is non-neuronal. Neurotrophins regulate the nervous system, in particular, nociception and thermal regulation. TRK is also expressed in monocytes. NTRK1 exists as low affinity monomeric, and high affinity dimeric structures with TRKA, TRKB, or TRKC, that bind neurotrophins. TRKA, TRKB, and TRKC partners are preferred by NGF, NTF5 and BDNF, and NTF3, respectively. Ligands stimulate autophosphorylation of TRK. NTRK1 defects cause CIPA. (From SWISS-PROT, OMIM and NCI)"                                                                                                        
[17924] "ETS family proteins exhibit sequence homolgy with the transcription factor ETS protooncogene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17925] "Expressed in all hematopoietic lineages, except T-cells, human SPI1 Gene (ETS Family) at 11p12-p11.22 encodes 264-aa 30-kDa nuclear ETS-domain PU.1 Transcription Factor, essential for myeloid (osteoclast progenitors) and B-lymphoid cell development. SPI1 binds as a monomer to the purine-rich lymphoid-specific enhancer DNA PU-box (5'-GAGGAA-3'). Graded expression specifies distinct hematopoietic cell fates; low concentration induces B-cell fate, high concentration promotes macrophage differentiation.  SPI1 is required for p47-phox promoter activity in myeloid cells and its expression is increased with osteoclastogenesic induction by 1, 25-dihydroxyvitamin D3. SPI1 is thought to regulate FMS and CD18/11B transcription, central to the osteoclast phenotype. SPI1 is highly expressed in erythro-leukemia cells that have undergone SPI1 gene rearrangements due to SFFV insertion. (NCI)"                                                                           
[17926] "TIAM1 appears to function in cellular signaling by modulating activation the GDP-GTP exchange activity of RHO-like GTPases that regulate cytoskeletal organization.  The serine-rich TIAM1 protein contains a DH domain, a PDZ/DHR domain, and two PH domains.  The DH domain is found in GDP-GTP exchanger proteins that activate RHO-like GTPases and PH domains are thought to be involved in protein-protein interactions.  TIAM1 activates RAC1, CDC42, and to a lesser extent RHOA.  (from OMIM 600687 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17927] "SPI1 is a putative oncogene specifically activated in acute murine erythroleukemias, induced by the Friend spleen focus forming virus.  It encodes PU.1, an ETS-domain transcription factor normally expressed in all hematopoietic lineages except in T-cells, and is essential for myeloid (osteoclast progenitors) and B-lymphoid cell development.  A low concentration of PU.1 induces the B-cell fate, whereas a high concentration promotes macrophage differentiation.  (from OMIM 165170 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17928] "p61-YES is associated with tyrosine-specific protein kinase activity, shows a high degree of homology with SRC, and contains one SH2 domain and one SH3 domain. (from OMIM 164880, Swiss-Prot P07947, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17929] "A member of the ETS family of transcription factors closely related to FLI1, Transforming Protein ERG shows homology to two domains of the ETS oncogene.  ERG1 and ERG2 are products of alternative splicing and polyadenylation, as well as translation initiation.  ERG2 is a nuclear phosphoprotein that binds to purine-rich sequences.  Like other ETS proteins, ERG2 is a sequence-specific DNA-binding protein and expressed at higher levels in early myeloid cells than in mature lymphoid cells.  ERG2 acts as a regulator of genes required for maintenance and/or differentiation of early hematopoietic cells.  (from OMIM 165080 and NCI)"                                                                                                                                                                                                                                                                                                                                            
[17930] "May serve as part of a signaling pathway coupling the FC receptor to the activation of the respiratory burst.  Furthermore, it may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.  p60-HCK and p59-HCK are produced by alternative initiation from the same proto-oncongene HCK.  Both are expressed predominantly in cells of the myeloid and b-lymphoid lineages, thus also called B-cell/Myeloid kinase.  Contains 1 sh2 domain and 1 sh3 domain. Has been mapped to chromosomal location 20q11-q12."                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17931] "Human AP2 Gene (AP2 family) at 6p24 encodes AP-2, a dimeric 52 kD transcription factor that binds to 5 prime-GCCNNNGGC-3 prime sequence in the SV40 promoter and in cellular enhancer elements, such as the metallothionein gene.  The AP2 mRNA is derived from seven exons distributed over 18 kb.  Four isoforms may be produced by alternative splicing.  The promoter contains a consensus AP2 binding site and is subject to positive autoregulation.  An alternatively spliced form of AP2 does not bind the consensus site and inhibits AP2 binding.  AP2 can form homodimers, or heterodimers with other members of the AP2 family, and activates genes involved in a large spectrum of biological functions, including development.  AP2 factors also suppress many genes, including MCAM/MUC18, C/EBP-Alpha and MYC.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                   
[17932] "WNT1 protein is a cysteine-rich secreted glycoprotein homologue of the Drosophila wingless segment-polarity gene product.  It is probably a signaling protein acting in CNS mesencephalon and metencephalon development.  (from OMIM 164820 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17933] "Encoded by human WNT5A Gene (WNT Family), 365-aa 41-kDa (precursor) WNT5A Protein, a cysteine-rich secreted glycoprotein growth factor, is involved in embryonic cell migration and axis induction. Frizzled-5 is a 7 transmembrane receptor for WNT5A ligand, which shows 98%, 98% and 87% amino acid identity to mouse, rat, and xenopus Wnt5A proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17934] "Thyroid Hormone Receptor Genes (Nuclear Receptor Family), c-erbA alpha and c-erbA beta, encode two isoforms each of c-erbA proteins (Thyroid Hormone Receptor) that specifically bind thyroid hormones and, thereby activated, regulate target gene transcription. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17935] "The WT2 protein is the putative protein encoded by the WT2 gene, a second Wilms tumor suppressor gene locus.  Efforts to clone the WT2 gene(s) have not yet been successful.  (from OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17936] "BLYM oncoprotein is the product of the BLYM oncogene, activated in certain human B lymphoid tumors.  BLYM contains regions of similarity to the amino terminal region of transferrins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17937] "Similar to other ETS transcription factors, ERGB Transcription Factor (FLI1) regulates expression of the TGF-beta type II receptor gene.  FLI1 contains one PNT domain, can form homodimers or heterodimers with ETV6/TEL1, and recognizes the sequence C[CA]GGAAGT.  Two isoforms may be produced by alternative splicing.  A form of Ewing's sarcoma is characterized by the chromosomal translocation t(11;22)(q24;q12), which involves FLI1 and EWS. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17938] "Encoded by Apoptosis Promoter Genes, Apoptosis Promoter proteins promote the initiation, progress, or rate of apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17939] "The Fibroblast Growth Factor Gene Family encodes Fibroblast Growth Factor peptides, potent mitogens that stimulate mesodermal cell growth, including chondrocytes, granulosa, and endothelia, and may be active in wound healing and regeneration. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17940] "Widely expressed at low levels, human Fibroblast Growth Factor 2 Gene (FGF family) at 4q25-q27 encodes a wide-spectrum mitogenic/angiogenic/neurotrophic factor, highly expressed in brain and pituitary.  Basic FGF is encoded by a single gene split by at least two introns greater than 15 kb.  Monomeric FGF2 is implicated in limb development, angiogenesis, wound healing, tumor growth, and other processes.  Basic FGF binds heparin more strongly than acidic FGF, can influence anteroposterior neural pattern, and may be a posteriorizing inducer.  Cardiac mesoderm, which expresses FGF1, FGF2, and FGF8, causes liver development from the foregut endoderm.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                    
[17941] "Human Fibroblast Growth Factor 7 Gene (FGF family) at 15q15-q21.1 encodes 28 kD FGF7, which stimulates epithelial cell (predominantly keratinocyte) growth, but lacks mitogenic activity on fibroblasts or endothelial cells.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17942] "Expressed in neonatal brain, human Fibroblast Growth Factor 5 Gene (FGF family) at 4q21 has a three-exon structure typical for this family.  Two isoforms are produced by alternative splicing.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17943] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17944] "The PTC1 chimeric oncogene (RET/PTC1, RET/H4) is generated by fusion of the RET proto-oncogene receptor tyrosine kinase domain to the 5-prime terminal region of the H4 gene containing a putative leucine zipper. H4 shows no significant homology to known genes and the protein function is unknown. The RET receptor ligand is Glial Cell Line-Derived Neurotrophic Factor. The putative H4 leucine zipper mediates dimerization of the PTC1 oncoprotein, essential for PTC1 transforming activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[17945] "Natural factors which stimulate blood vessel production."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17946] "A product of the NOV gene.  It is a member of the CCN family of proteins, expressed after induction by growth factors.  CCN proteins share several motifs: an IGFBP motif, an oligomeric complex-forming domain, a binding domain for soluble and matrix molecules, and a dimerization CT domain.  All CCN members are thought to control cell proliferation.  (from OMIM 164958 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17947] "Human MAX Gene (MYC family) at 14q23 encodes MYC-Associated Factor X, a bHLH/ZIP transcription factor phosphoprotein.  At least three isoforms are produced by alternative splicing.  High levels are found in brain, heart, and lung; lower levels in liver, kidney, and skeletal muscle.  Unlike most immediate early genes like MYC, MAX mRNA is relatively stable and not modulated with respect to cell proliferation.  DNA binding by MAX requires dimerization with another bHLH protein.  MAX forms a transcription regulatory complex with MYC and with MAD that recognizes 5 prime-CAC(GA)TG-3 prime.  MYC/MAX is an activator; MAD/MAX is a repressor.  MAX binds to the MYC gene and DDX18, a DEAD box family member.  MAX also interacts with MIX2. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                  
[17948] "Product of the TP73 gene.  A p53 homologue.  It is independently activated from p53 and represents a separate route to apoptosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17949] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17950] "Encodes core-binding factor alpha, part of the heterodimeric transcription factor Core-Binding Factor.  The CBFalpha subunit binds directly to the enhancer core DNA sequence on target genes, whereas the beta subunit does not bind the DNA directly but increases the affinity and stabilizes the binding of the alpha subunit to the DNA.  Three homologous genes can encode for the CBFalpha subunit.  Disruption of CBFA2 is associated with many leukemias, including AML, ALL, and CML."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17951] "The PTTG1 proto-oncogene affects cell cycle regulation, proliferation, and cellular transformation by its involvement in regulation of chromatid separation.  PTTG1 encodes a cytosolic, proline-rich protein with several SH3 sites and an N-terminal basic and C-terminal acidic domain.  The gene product is Securin, a likely Anaphase-Promoting Complex substrate associated with ESP1 until activation of APC.  Securin contains a conserved destruction (D) box motif shared by many APC substrates.  Securin may function through SH3-mediated signal transduction pathways and activation of growth factors.  Securin is essential for the maintenance of euploidy and its effect on chromatid separation takes place through its APC interaction.  PTTG1 is highly expressed in many tumors."                                                                                                                                                                                             
[17952] "Product of the PTTG1 Gene.  It is an anaphase-promoting complex substrate, involved in regulation of chromatid separation.  Has effects on cell cycle regulation, cellular proliferation, and cellular transformation.  It is a cytosolic, proline-rich protein with several SH3 sites and N-terminal basic and C-terminal acidic domains."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17953] "Angiogenesis inhibitory proteins are natural factors that block blood vessel production."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17954] "Gene defective in Ataxia telangiectasia disease.  Results in a defect in cell cycle regulation and DNA repair.  Associated with sensitivity to DNA damaging agents such as ionizing radiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17955] "The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis and osteogenesis. The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. (from LocusLink)"                                                                       
[17956] "The 100 kb human MLL Gene (TRX family) at 11q23 contains at least twenty-one exons and encodes a 431 kD nuclear HRX protein.  Homologous to DNA methyltransferase and containing N-terminal AT-hook motifs, HRX has three regions of homology to trithorax (Drosophila), including cysteine-rich regions that fold into six zinc finger-like domains.  Expressed in heart, lung, brain, and T- and B-lymphocytes, the evolutionarily conserved MLL gene may be unique in the human genome.  With features of a DNA-binding protein, HRX may bind within the minor groove of AT-rich DNA and is a likely transcriptional regulator.  HRX localizes to nuclear structures, contains a bromodomain, a SET domain, three PHD zinc fingers, and a CXXC zinc finger.  The gene is frequently involved in rearrangements in AML.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                        
[17957] "Tumor promoter induced genes are expressed shortly after cell exposure to tumor promoters."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17958] "A lung cancer modifier, human GSTM1 Gene (GST family) at 1p13.3 is expressed in adult liver, kidney, adrenal gland, and stomach and weakly in skeletal and cardiac muscle.  GSTM1 is not expressed in fetal liver, fibroblasts, erythrocytes, lymphocytes, and platelets.  Clustered 20 kb apart, four GST mu genes are arranged 5-prime--GSTM4--GSTM2--GSTM1--GSTM5--3-prime.  Mammalian cytosolic GSTs are divided into alpha, mu, kappa, theta, pi, and sigma classes; there is also a class of microsomal GSTs.  Glutathione S-transferases metabolize a broad range of hydrophobic electrophilic xenobiotics and carcinogens.  Dimeric cytoplasmic GST M1 catalyzes glutathione addition to organic compounds forming thioethers, often a detoxification reaction leading to mercapturic acid formation.  By increasing sensitivity to some carcinogens, GSTM1 absence may be a risk factor for cancer.  (from SWISS-PROT, OMIM, and NCI)"                                                     
[17959] "The COMT gene is a human breast cancer modifier/susceptibility gene that encodes a member of the Catechol-O-Methyltransferase gene family.  COMT catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, such as dopamine, epinephrine, and norepinephrine, in a major degradative pathway.  In addition, COMT metabolizes catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease.  The human gene is located at 22q11.21-22q11.23."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17960] "A cloned gene for Hereditary Non-Polyposis Colon Cancer, the PMS1 Gene (MUTL/HEXB family) at 2q31-q33 is associated with colon, endometrial, and stomach cancers. The PMS1 gene encodes DNA Mismatch Repair Protein PMS1, which is implicated, with MSH2 and MLH1, in mismatch repair of dinucleotide and trinucleotide sequences. Human PMSL genes exhibit homology to bacterial mutL genes and yeast PMS1 gene. (From SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17961] "Associated with colon, endometrial, and stomach cancers, the ubiquitously expressed PMS2 Gene (MUTL/HEXB family) at 7p22 consists of 15 exons that encode DNA Mismatch Repair Protein PMS2, involved with MSH2 and MLH1 in mismatch repair of dinucleotide and trinucleotide sequences. PMS2 is part of the BASC genome surveillance complex. MSH2 and MLH1 interact with PMS1, PMS2, and MSH6. Essential for repair of replication slippage errors, PMS2 is a cloned gene for Turcot syndrome and Hereditary Non-Polyposis Colon Cancer. Transcribed from the opposite strand, JTV1 overlaps PMS2. (From SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                               
[17962] "The tumor suppressor TGFBR2 gene is a cloned gene for Hereditary Non-Polyposis Colon Cancer that encodes a putative transforming growth factor beta receptor II, a serine/threonine kinase receptor family member.  TGFBR2, a heteromeric complex, mediates growth inhibition of many epithelial cell types and hypophosphorylation of RB; loss of this negative regulation is thought to contribute to tumor development.  The TGFBR2 gene is regulated by ETS transcription factors and is a likely target of the EWS-FLI1 fusion protein found in Ewing sarcoma.  The human gene is located at 3p22."                                                                                                                                                                                                                                                                                                                                                                                            
[17963] "The CDK Inhibitor Genes encode the CDK Inhibitor Proteins, a group of low molecular weight proteins that associate with cyclin-CDK complexes or CDKs alone and inhibit their activity. (From OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17964] "BLCA-4 is a bladder-specific, nuclear matrix protein.  Elevated levels of BLCA-4 in the urine may identify individuals with bladder cancer. (from J Urol 2000. 164:634-639 via Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[17965] "Genes that make a person more or less resistant to a disease. These genes respond in special ways to certain extrinsic stimuli and thus tend to make the individual more than usually susceptible to certain diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17966] "The study and description of the fine structural changes that result from disease processes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17967] "Used in reference to proteins or low molecular weight solutes (ligands) that interact specifically with DNA, in either a DNA-sequence dependent or independent fashion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[17968] "Encoded by Apoptosis Inhibitor Genes, Apoptosis Inhibitor proteins impede the initiation, progress, or rate of apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17969] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17970] "The proto-oncogene PIM1 encodes a putative cytosolic serine/threonine protein kinase, up regulated in prostate cancer. The gene is highly expressed in the liver and spleen during fetal hematopoiesis and primarily in B-lymphoid and myeloid cell lines.  (from OMIM 164960 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17971] "The PVT1 protein is a product of the PVT1 gene, involved in some human Burkitt lymphomas, and a putative activator of MYC.  (from OMIM 165140 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17972] "The protein complexes or individual proteins that have the function of chromatin remodeling. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17973] "The PACE gene encodes paired basic amino acid cleaving enzyme, a ubiquitous proprotein endoprotease that functions within secretory pathways and is localized to the trans Golgi network.  PACE cleaves at RX(K/R)R consensus motifs in the proteolytic activation of pro-proteins and plays a significant role in tumor progression.  The human gene is located at 15q25-q26."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[17974] "Oncogene MAX is a member of the MYC gene family. The MAX gene encodes a bHLH/ZIP protein that forms a heterodimer with MYC and binds with high affinity to a DNA site in the MYC gene and DDX18, a DEAD box family member. MAX mRNA steady state level is not modulated with respect to cell proliferation or differentiation, unlike mRNAs encoded by most immediate early genes. MAX also interacts with MIX2. The human gene is located at 14q23."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[17975] "Patched is the sonic hedgehog receptor, a protein with twelve transmembrane domains that represses transcription of genes encoding TGF Beta and WNT family signaling proteins.  Patched is involved in embryonic development and adult cell growth control.  Sonic hedgehog binding to Patched appears to activate the 7-transmembrane protein Smoothened by release from Patched inhibition.  Basal cell carcinoma is associated with mutations that activate Smoothened or inactivate Patched, causing excess activity of the hedgehog response pathway.  The PTCH gene is a cloned gene for Basal Cell Nevus Syndrome, associated with skin cancer and childhood brain cancer.  (from OMIM 601309 and NCI)"                                                                                                                                                                                                                                                                                      
[17976] "Eph receptor tyrosine kinases and their ligands, the ephrins, appear to lie functionally at the interface between pattern formation and morphogenesis.  They play a major role in axonal pathfinding and target recognition during central nervous system (CNS) development.  (from Development 1999;126:2033-2044 and Exp Neurol 1999;156:218-22)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17977] "This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[17978] "Human HOX11 Gene (HOX family) at 10q24 encodes HOX11 Protein, a homologue of DNA-binding homeobox transcription factors.  Located outside the four HOX clusters, HOX11 is an orphan homeobox gene.  Orthodox HOX genes encode a coordinate system of embryonic anterior-posterior axis specification; orphan homeobox genes are less understood.  Essential for survival of splenic precursors during organogenesis, HOX11 binds to 5 prime-GGCGGTAAGTGG-3 prime DNA.  Mutant HOX11 can be oncogenic; some childhood T-cell acute leukemias involve deregulated activation (by translocation adjacent to TCRD or TCRB) of an unaltered HOX11 gene. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                
[17979] "A cloned gene for Familial Gastrointestinal Stromal Tumor, the 70 kb human C-KIT Gene (CSF1R/PDGFR family) at 4q12 encodes a transmembrane receptor tyrosine kinase for SCF.  It is critical in pluripotent hematopoietic stem cell development, migrating embryonic melanoblasts, and primordial germ cells.  Located within 700 kb of PDGFRA, c-KIT includes twenty-one exons and is alternatively spliced; the longest transcript is 5.2 kb.  The overall gene structure resembles that of CSF1R.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[17980] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17981] "The Office of Administrative Management, develops and executes the administrative, fiscal, and management aspects of (institute) programs. The Office of Administrative Management plans and directs the day-to-day administrative functions of (the institute) through the following sections: administrative management; financial management; grants and contracts management; and personnel management. (from NHGRI: Mission Statement and Organization October 1995)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17982] "To create and encourage a stimulating approach to disease curricula that will attract high-quality students, foster academic career development of promising young teacher-investigators, develop and implement excellent multidisciplinary curricula through interchange of ideas, and enable the grantee institution to strengthen its existing teaching program. (Grant Guidelines and Descriptions, NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17983] "Oversight and management of grants or contracts"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17984] "A subdiscipline of nursing focusing on care for patients with short term illnesses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[17985] "These provide administrative supplements to existing NIH research grants for the purpose of 1) promote reentry into biomedical and behavioral research careers 2) promote the recruitment of individuals with disabilities into biomedical research careers and 3) attract underrepresented minorities into biomedical and behavioral research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[17986] "A subdiscipline of nursing focusing on general and comprehensive nursing care directed to adults."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17988] "Study of the occurrence, distribution, and containment of the acquired immunodeficiency syndrome (AIDS).  Used for the scientific discipline as a whole or for specific epidemiological factors or findings (e.g., AIDS incidence or prevalence statistics). (from PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17989] "Subgroups of AIDS patients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[17990] "AIDS related research with a minimum of 20% research efforts related to females 12 years of age or older. To include: Pregnant women, Women at risk of HIV infection, Transmission of HIV between heterosexual partners, Female prostitutes, Perinatal transmission of HIV. (FMB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[17991] "AIDS related research with a minimum of 20% (or $100,000) relevance to individuals of African descent"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[17992] "AIDS related research with a minimum of 20% (or $100,000) relevance to individuals of Mexican, Cuban, Puerto Rican, Central American, or South American descent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17993] "AIDS related research with a minimum of 20% (or $100,000) relevance to individuals of homosexual orientation"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[17994] "AIDS related research with a minimum of 20% (or $100,000) research efforts related to foreign countries.  To include: Awards to scientists or organizations outside the U.S.A.; awards to international organizations such as WHO and PAHO; Projects where at least 20% (or $100,000) of the funds are related to training a U.S. scientist outside the U.S.A or a non-U.S. scientist in the U.S.A.; Projects where at least 20% (or $100,000) of the activity takes place outside the U.S.A.; Projects where at least 20% (or $100,000) of the funds are related to international exchange or international travel."                                                                                                                                                                                                                                                                                                                                                                               
[17995] "AIDS related research with a minimum of 20% (or $100,000) research efforts related to individuals of non-Caucasian descent, and individuals of Hispanic descent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17996] "AIDS related research with a minimum of 20% (or $100,000) relevance to individuals who are Asian/Pacific Islanders or Native Americans, including American Indians, Alaskan Natives, and Hawaiian Natives."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[17997] "AIDS related research with a minimum of 20% (or $100,000) research efforts related to females 12 years of age or older. To include: Pregnant women, Women at risk of HIV infection, Transmission of HIV between heterosexual partners, Female prostitutes, Perinatal transmission of HIV."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[17998] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[17999] "Occupations of medical personnel who are not physicians, and are qualified by special training and, frequently, by licensure to work in supporting roles in the health care field. These occupations include, but are not limited to, medical technology, physical therapy, physician assistant, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18000] "Scientific discipline concerned with the development of methods and application of these methods to detect, identify, and quantify biological materials, e.g. proteins, nucleic acids, metabolites.  See analytic chemistry."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18001] "The study of genetic traits in animals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18002] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18004] "The science concerned with the normal processes of hearing"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18005] "Studies of the interactions between mind and physiology in relation to hearing perception."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18006] "Autoradiographic analysis performed by mounting the object for microscopy, e.g. on a glass slide, and bathing the object with a photographic emulsion that will record radioactive disintegrations occurring at close proximity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18007] "Autoradiographic analysis performed following certain guidelines that will result in a defined correspondence between the intensity of the autoradiographic image and the amount of radioactivity present in the sample.  This permits assigning a value to the amount of (radioactive) material in the object under study."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18008] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18009] "The appraisal of the biological activity of a substance by testing its effect on an organism and comparing the result with some agreed standard."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18010] "The study of the chemistry of endocrine hormones in living organisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18011] "The study of the energy changes involved in physical and chemical reaction, changes, and systems of living organisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18012] "DCEG: Biochemical or molecular epidemiology incorporates the collection of biologic specimens in epidemiologic investigations, which can be analyzed by laboratory techniques to gain better insights into specific environmental and genetic determinants of disease, precursor states, and the pathogenic mechanisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18013] "The branch of biochemistry dealing with the chemical nature and biological activity of enzymes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18014] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18015] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18016] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18017] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18018] "Delineate the molecular and cellular mechanisms of establishment and systemic spread of infection and their impact on disease progression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18019] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18020] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18021] "Techniques for separation of biomolecules from suspensions or mixtures based on physical and chemical properties.  Examples include: ion exchange columns, gel filtration methods, affinity chromatography, HPLC, aqueous two phase partitioning and membrane separation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18022] "Techniques, specialties or disciplines for the development or modification of apparatus, instruments, or equipment for diagnostic or therapeutic procedures, analytic or other biological use. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18023] "A value used as a form filler when no specified type of Biophysics is appropriate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18024] "Development of fermentation processes for the biotech industry."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18025] "Techniques using equipment such as a hollow fiber apparatus or roller bottles for high volume maintenance or growth of animal, plant, or insect cells in vitro. It refers to cultures derived from dispersed cells taken from the original tissue, from a primary culture, or from a cell line or cell strain by enzymatic, mechanical, or chemical disaggregation. (From Dorland, 28th ed; Freshney, Culture of Animal Cells, 3d ed, p1) (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18026] "Peptide Nucleic Acid (PNA).  Nucleic acid analogue containing a N-(2-aminoethyl)glycine backbone instead of a sugar phosphate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18027] "A report by the Ad Hoc Working Group of the National Cancer Advisory Board presented on June 9, 1995, outlining, in detail, the state of the intramural research program of the National Cancer Institute.  The Ad Hoc Working Group was headed by J. Michael Bishop and Paul Calabresi."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18028] "The branch of pathology that focuses the causes and nature and effects of diseases of the bone and connective tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18029] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18030] "RAEB: Programs or materials to provide information on breast cancer prevention, detection, or treatment to health professionals, patients and their families, the public, or high-risk groups."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18031] "Breast cancer genetics involve clinical, epidemiologic and/or laboratory evaluations of individuals and their families who are at high risk of developing breast cancer due to hereditary predisposition.  These studies are aimed at identifying susceptibility genes for breast cancer and their associated molecular and genetic aberrations, as well as the functions of their encoded proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18032] "RAEB: Examples: surgical reconstruction, less mutilating surgery, psychological counseling. See SIC 66 (rehabilitation)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18033] "RAEB: Environmental or molecular epidemiology of human breast cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18034] "The study of the origins, growth, and treatment of any of various types of malignant neoplasms, most of which invade surrounding tissues, may metastasize to several sites, and are likely to recur after attempted removal and to cause death of the patient unless adequately treated; especially, any such carcinoma or sarcoma, but in ordinary usage, especially the former."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18035] "The Office of Cancer Communications supports a nationwide network of offices known as the Cancer Information Service (CIS). The CIS serves as the NCI's primary mechanism to disseminate accurate up-to-date information to the American public at the communit"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18036] "Field of medicine concerned with the determination of causes, incidence, and characteristic behavior of cancer outbreaks affecting human populations. It includes the interrelationships of host, agent, and environment as related to the distribution and control of cancer(s). (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18037] "Study of the causes and origins of cancer(s). (from PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18038] "Research that contributes to the understanding of the role of the immune system in controlling the development, growth, and spread of tumors, and includes studies of the basic transplantation biology relevant to tumor rejection and to immune reconstitution.  Includes technologies to facilitate this research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18039] "The Cancer Prevention Fellowship Program provides for: Master of Public Health training, participation in the Cancer Prevention and Control Academic Course, mentored research, and brief field assignments in cancer prevention or cancer control programs at other institutions (from Cancer Prevention Fellowship Program/Description)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18040] "A forecast of the probable course and outcome of a cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18041] "An individual who has survived a cancer, and is in a disease free, chronic, or relatively stable stage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18042] "RAEB: This category is used for any long-term problems or challenges in persons treated for cancer, including surgically-induced limitations, adaptation to laryngectomy, amputation, prostheses. Also include long-term psychological difficulties in coping with cancer or its treatment on the part of the patient or family; cancer-related employment or insurance discrimination; sexual dysfunction."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18043] "Virus as an agent in the cause of a cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18044] "The study of the biological and physiological chemistry of carbohydrates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18045] "Chemistry of molecules having the form Cn(H2O)n"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18046] "Studies of the role of biological agents as factors or cofactors in the etiology of human and animal cancer.  Studies encompass a wide range of approaches, including basic biochemistry and molecular biology of oncogenic and suspected oncogenic agents, viral oncogenes and associated tumor suppressor genes, pathogenesis and natural history studies, animal models, and preventive vaccine research.  The development of technologies to facilitate studies relating to biological carcinogenesis research are included."                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18047] "These are studies which use more than one type of agent to induce cancer, where one agent alone does not induce cancer, but it does when in combination with others."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18048] "The study of carcinogens involving hormonal action which results in cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18049] "1. The means by which the origination, production, or development of cancer is obtained. 2. Research concerned with the metabolism, toxicity, physiological disposition, and mechanisms of action of carcinogens and their metabolites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18050] "Studies to identify the mechanisms by which physical agents cause cancer"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18051] "1. The origin or production, or development of cancer, as a result of exposure to ionizing radiation. 2. The study of the processes by which normal cells, exposed to ionizing radiation, are transformed into cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18052] "The functions and activities of the cardiopulmonary system as a whole or of any of its parts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18053] "Methods for building collections of cloned DNA consisting of DNA copies of all the mRNAs produced by a cell type.  cDNAs are generated using reverse transcriptase and either an oligo-dT or random primer.  The copies are inserted into a bacterial plasmid or bacteriophage vector.  The library can be maintained as a pooled population or as an arrayed library."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18054] "A difference cloning method and a technique for comparison of two closely related cell types, e.g. a differentiated or transformed cell (tester) and the undifferentiated or normal cell (driver). Driver RNA is converted to double-strand cDNA, usually with the incorporation of a tagged nucleotide, while the tester RNA is converted to first-strand cDNA (with no tag). The two preparations are mixed, melted and annealed to form, among other species, heteroduplexes composed of one strand from each of the different sources. The annealed heteroduplexes, as well as other driver species are captured by the tagged nucleotide and removed from the mixture. The resulting pool will be enriched for those cDNA species unique to the tester cells. Following second-strand synthesis, the double-stranded cDNAs are cloned. The resulting cDNA library will be enriched for sequences expressed only in the tester cells. cDNA subtraction can also be done by PCR. (NCI/OSP)"      
[18055] "CDNA expressed as protein formation"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18056] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18057] "Cell cycle checkpoints are phases or points in the cell cycle at which a cell is prevented from progressing into the next phase of the cycle unless certain necessary and sufficient cellular conditions exist.  The checkpoints help maintain the proper order and timing of cell transition events, especially important for DNA replication and chromosome segregation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18058] "The cells in the body and how they are involved in immunity"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18059] "A medical specialty focusing on the normal blood circulation of the brain and on changes due to pathology."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18060] "RAEB: Programs or materials to provide information on cervical cancer prevention, detection, or treatment to health professionals, patients and their families, the public, or high-risk groups."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18061] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18062] "Measuring the amount of reagents, energy, radiation or product that was involved with a chemical reaction"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18063] "Cells derived from the chicken used as a biological model for research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18064] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18065] "Staining of metaphase spreads for crossovers, inversions, and translocations.  Includes karyotyping, fluorescence in situ hybridization, and chromosome painting. (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18066] "The technique whereby chromosomes are exchanged among cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18067] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18068] "The clinical specialty of endocrinology that focuses on the endocrine organs and their role in physiology and pathology."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18069] "The medical field that deals with immune diseases, including autoimmune diseases, allergies, rejection of organ transplants and immune deficiency."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18070] "The discipline focusing on microbe-induced clinical conditions, including epidemiology, pathogenesis, diagnosis and detection, and prevention and treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18071] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18072] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18073] "A specialty in biology and medicine focusing on aspects of human parasitology that directly pertains to parasite-induced clinical conditions, including epidemiology, pathogenesis, diagnosis and detection, and prevention and treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18074] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18075] "A grant that uses materials from some other clinical trial."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18076] "A subdiscipline of virology focusing on aspects of human virology that directly pertains to virus-induced clinical conditions, including epidemiology, pathogenesis, diagnosis and detection, and prevention and treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18077] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18078] "Technique for making and testing many complex materials in parallel: computer guided synthesis in which all possible combinations are made. Combinatorial synthesis is not random, but systematic and repetitive, using sets of chemical \"building blocks\" to form a diverse set of molecular entities.  Initial synthesis is usually made on a solid substrate. The technique lays down the materials in a checkerboard arrangement, as thin squares arranged in a grid.  Scientists use combinatorial chemistry to create large populations of molecules, or libraries, that can be screened efficiently en masse. (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                   
[18079] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18080] "The study of the similarities and differences between different living organisms of the biological and physiological chemistry of the organisms. Used for the scientific discipline or the biochemical processes themselves. (from PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18081] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18082] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18083] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18084] "RAEB: Chemically-modified substances, usually proteins, to target a compound to a site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18085] "Support research for the discovery, development, and evaluation of strategies for preventing or minimizing the negative physical, psychological, cognitive, and social consequences of HIV, including stigmatization of persons with or at risk for HIV infection. Support research strategies for promoting effective health care utilization among persons with HIV infection"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18086] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18087] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18088] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18089] "Support research for the discovery, development, and evaluation of strategies for preventing or minimizing the negative physical, psychological, cognitive, and social consequences of HIV, including stigmatization of persons with or at risk for HIV infection. Support research strategies for promoting effective health care utilization among persons with HIV infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18090] "Groups of individuals that exhibit differing characteristic behavior in customs, attitudes, practices, and behaviors, or are predisposed to certain health histories due to differences in ethnicity, race, religion, national origin, or economic standing (DCCPS)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18091] "The study of the biological and physiological chemistry of cyclic nucleoside monophosphates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18092] "The science concerned with the chemistry, actions, and uses of cyclic nucleoside monophosphates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18093] "A family of enzymes that catalyze the transfer of a phosphate group using CTP as the donor molecule (EC 2.7.7.x)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18094] "Database management involves the design and maintenance of electronic data storage systems to facilitate and optimize the categorization, selection, and retrieval of information."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18095] "Studies into the link between dental and oral health and systemic disease.  Oral health problems have been associated with an increased risk for a variety of systemic diseases including cardiovascular disease, respiratory disease, preterm and low birth weight infants, and earlier death.  Studies are needed that evaluate physiological pathways that connect oral and systemic conditions.  (Oral and Dental Epidemiology: http://www.hsph.harvard.edu/epidemiology/academics/oralepi.htm)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18096] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18097] "Processes that involve and promote formation of more mature organs, organ systems, or organisms; general development. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18098] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18099] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18100] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18101] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18102] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18103] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18104] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18105] "The study of the psychological, physiological, and behavioral changes in an organism that occur from birth to old age."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18106] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18107] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18108] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18109] "Dietary Factors; the consideration of dietary factors as a variable in disease incident, transmission, and control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18110] "Progressive restriction of the developmental potential and increasing specialization of function which takes place during the development of the embryo and leads to the formation of specialized cells, tissues, and organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18111] "NCI Director's Working Groups are ad hoc \"think tanks\" appointed to address key scientific issues. Their members include leaders in laboratory, clinical, and population-based research drawn from the extramural and intramural research community, staff of the NIH and other government agencies, members of professional organizations, and interested consumers and patient advocates. Their recommendations will provide a framework for Institute strategic planning and for the development of operational plans by NCI divisions. (National Cancer Institute-1999 Budget Request)"                                                                                                                                                                                                                                                                                                                                                                                                       
[18112] "Improve understanding of the structure and function of molecular targets in order to develop improved assays for such targets; conduct screening, discovery, and preclinical development of novel anti-HIV agents and strategies (such as gene transfer technology and interruption of transmission) directed to the virus and/or host cell; and foster industrial activity and collaborations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18113] "The Division of Cancer Biology (DCB) was created by the reorganization of NCI in 1995, and has the principal Federal responsibility for managing a grant- and contract-supported program of basic and applied research on cancer cell biology, including research on carcinogenesis and cancer immunology. In addition to investigating basic cellular mechanisms, this research includes examination of the role of biological, chemical, and physical agents in the initiation, promotion or inhibition of cancer and the biological and health effects of exposures to ionizing and non-ionizing radiation."                                                                                                                                                                                                                                                                                                                                                                                     
[18114] "The Division of Cancer Epidemiology and Genetics (DCEG) is the primary focus within the National Cancer Institute for population based research on environmental and genetics determinants of cancer. Intramural and collaborative interdisciplinary studies are conducted on the distribution, causes, and natural history of cancer, and the means for its prevention. Research areas of special interest include genetic predisposition, lifestyle factors, environmental contaminants, occupational exposures, medications, radiation and infectious agents, as well as statistics and methods development."                                                                                                                                                                                                                                                                                                                                                                                    
[18115] "Reorganized on October 1, 1997 to the extramural Division of Cancer Prevention and the extramural Division of Cancer Control and Population Science."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18116] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18117] "Merged with the Division of Basic Sciences in January, 2001 to form the Center for Cancer Research"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18118] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18119] "Damage to DNA caused by ionizing radiation.  Can cause base change mutations or strand breakage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18120] "The biochemical and biophysical properties governing the binding of proteins to DNA"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18121] "A dominant-negative mutation produces a mutant gene product that can inhibit the function of the wild-type gene product in heterozygotes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18122] "Drosophila Patched Gene (Patched Family) encodes Patched protein, an integral membrane protein containing an SSD domain that acts as a segmentation polarity pattern receptor for hedgehog during embryonic segmentation and during imaginal disk development. Patched associates with smoothened protein to transduce hedgehog signal, leading to activation of wingless, decapentaplegic, and patched. In the absence of hedgehog, patched represses constitutive smoothened signaling through fused. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18123] "Viral nuclear antigen expressed in latency"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18124] "Methods for preserving egg cells such as oocyte cryopreservation in liquid nitrogen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18125] "Methods for short term or long term preservation of embryos at the two cell stage or beyond.  Examples: short term storage in buffered media with serum at reduced temperature or long term cryopreservation in liquid nitrogen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18126] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18127] "Currently undefined."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18128] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18129] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18130] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18131] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18132] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18133] "The consideration of age and sex as variables in disease incident, transmission, and control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18134] "DCEG: Environmental epidemiology focuses on exposures that are external to the individual, including physical, chemical, biologic, soci-cultural and lifestyle factors that influence the risk of disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18135] "The consideration of geographic location as a variable in disease incident, transmission, and control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18136] "The consideration of occupation as a variable in disease incident, transmission, and control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18137] "An account of all medical events and problems a person has experienced."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18138] "The consideration of race and/or ethnic origin as variables in disease incident, transmission, and control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18139] "The consideration of tobacco, alcohol, or drug use as variables in disease incident, transmission, and control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18140] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18141] "The various effects, including growth, differentiation, and death, imposed on epithelial cells by the surrounding matrix and neighboring accessory cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18142] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18143] "Support research to identify existing gaps in communications approaches, identify existing strategies that are effective, and develop and test new and innovative communication strategies that will improve access to and use of state-of-the-art HIV information by all relevant target audiences. (FMB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18144] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18145] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18146] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18147] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18148] "The use of animals to study psychological traits such as math reasoning or ability to learn."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18149] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18150] "Laboratory tumor modeles used to study tumor development and treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18151] "The genetics of extra-nuclear DNA, eg. Mitochondria and chloroplasts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18152] "Extramural Activities; research activities which take place off the NIH campus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18153] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18154] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18155] "General and comprehensive nursing practice directed to families.  Often involves home visits."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18156] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18157] "The National Cancer Institute (NCI) offers training fellowships to individuals who are interested in careers in cancer epidemiology, biostatistics, or genetics.  DCEG supports two programs: One provides pre- and postdoctoral training in cancer epidemiology and biostatistics, and the other provides postdoctoral interdisciplinary training in cancer genetics and epidemiology. (from DCEG fellowship programs)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18158] "F31: Predoctoral Individual National Research Service Award, F32: NIH National Research Service Award for Individual Postdoctoral Fellows, F33: National Research Service Award--Senior Fellowships, F34: MARC NRSA Individual Post-doctoral Program Appointee, F35: Intramural NRSA Individual Postdoctoral Program Appointee, F36: MARC Visiting Scientists Fellowships (NIGMS) (from NIH Guide for Grants and Contracts Extramural Policy Notices)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18159] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18160] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18161] "The 5-A-Day message is \"Eat 5 servings of fruits and vegetables a day for better health.\" (5-A-Day For Better Health, NIH Guide, Volume 21, Number 12, March 27, 1992)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18162] "A type of centrifugation technique equipped with photograph capability.  It allows you to determine the time it takes a particle to travel in the cell of the rotor under standard conditions while it is spinning."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18163] "Separation of particles on the basis of their differential sedimentation rate. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18164] "The type of centrifugation used to separate cell components.  Consists of two basic procedures: differential centrifugation and density gradient centrifugation (from http://www2.uca.edu/biology/johnc/FRACTION.htm)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18165] "Methods of fractionation, isolation, and purification based on the physico-chemical properties of the substance, e.g. crystallization, distillation, solubility (miscibility)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18166] "A government-owned, contractor operated cancer research facility located in Frederick, MD.  Operated under the direction of the Division of Cancer Biology."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18167] "The science concerned with the normal processes of the stomach and intestines and how they are affected by drugs or disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18168] "Models of human disease produced through gene knockout methods"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18169] "RAEB: Any level of human gene mapping: identifying the chromosome on which a given gene is located, its specific chromosomal location, or its nucleotide sequence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18170] "RAEB: Any level of non-human gene mapping; identifying the chromosome on which a given gene is located, its specific chromosomal location, or its nucleotide sequence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18171] "NIH Emphasis Area -- In the realm of genetic medicine, the rapid progress of the Human Genome Project, a growing understanding of the genomes of other species, and new methods for the manipulation of genes are swiftly changing concepts of disease and possibilities for its control.  The real possibility of being able to identify the inherited mutations that contribute to cancer risk, developmental abnormalities, immunodeficiencies, and mental and neurological disease (such as epilepsy, stroke, autism, and sensory disorders) deserve significant new effort."                                                                                                                                                                                                                                                                                                                                                                                                                   
[18172] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18173] "Risk of developing a disease based on a patients heredity"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18174] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18175] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18176] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18177] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18178] "Nursing practices for older age individuals"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18179] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18180] "An increase in global UV with the diminishing of the ozone layer"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18181] "Biochemistry of carbohydrates, aldehydic or ketonic derivative of polyhydric alcohols, the name being derived from the fact that the most common examples of such compounds have formulas that may be written Cn(H2O)n (e.g., glucose, C6(H2O)6; sucrose, C12(H2O)11), although they are not true hydrates and the name is in that sense a misnomer. The group includes compounds with relatively small molecules, such as the simple sThe study, at the molecular level, of the structural and functional roles of carbohydrate-containing structures and of the interactions of carbohydrates with other structures, especially proteins."                                                                                                                                                                                                                                                                                                                                                        
[18182] "The Division of Cancer Biology (DCB) supports a variety of investigator-initiated research grants from academic institutions, research institutes, and small businesses.  Two major types of grants are Program Announcements and Requests for Applications. (from DCB Grant Opportunities)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18183] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18184] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18185] "Monetary awards made by NIH for research and support services."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18186] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18187] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18188] "Inclusion of an individual in a peer or minority group"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18189] "Preventing the normal cycle of cellular growth and division."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18190] "Processes that involve and promote either specific or nonspecific formation of additional tissue mass, typically by cell proliferation; general growth. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18191] "The medical science and specialty practice concerned with all aspects of disease of the genital tract, endocrine system, and reproductive system of the female."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18192] "Nursing care of women, specifically with regard to childbearing and gynecological care."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18193] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18194] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18195] "RAEB: Promotion of the use of available health care resources and the adoption of more healthful lifestyles, and attempts to make resources available to underserved populations and to make these populations aware of the resource availability."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18196] "RAEB: programs at the work site to promote health, e.g., anti-smoking"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18197] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18198] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18199] "A funding category that should include all grants having to do with herpes research except those having to do with genital infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18200] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18201] "Radioactive particles that deposit a high amount of energy by radiation per unit length of travel. (from RAEB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18202] "1A1; Basic Sciences Research (includes vaccine and chemotherapy development); Biomedical Research; HIV and HIV Genome (structure, function)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18203] "2A2; Risk Assessment and Prevention; Surveillance; HIV surveys (incidence and prevalence)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18204] "Biologic functions, activities, or processes especially involving coordinated specialized immune system components that support surveillance and/or activation of immune responses to immunogenic substances. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18205] "This five year career development award provides a mechanism for bridging the transition from a mentored research environment to an independent research career for scientists who have demonstrated unusually high potential during their initial stages of training, career development and are focusing on human disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18206] "Primary human fetal tissue only, not fetal cell lines, not amniotic or chorionic (placental), or umbilical cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18207] "A molecular biology technique that utilizes a large set of defined oligonucleotide probes, recombinant clones, or other samples attached in a specific grid arrangement to a solid support for nucleic acid hybridization assays in gene mapping studies or in determining gene sequences, sequence variations, or gene expression patterns.  Includes DNA chip technology. (from MSH98, NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18208] "Any of a number of technologies that permits the capture or acquisition of images into a computer-readable format, or that transforms or processes a collection of linear or two-dimensional data into a three-dimensional visual representation that accurately reflects the physical or chemical state of an object."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18209] "Develop and evaluate strategies that will enhance, restore, and/or maintain the immune systems of HIV-infected individuals and extend our understanding of immunopathogenesis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18210] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18211] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18212] "Support the effective dissemination, communication, and utilization of HIV/AIDS information to all constituent communities of the NIH."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18213] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18214] "An account of all cancer-related events and problems a person has experienced."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18215] "infant death due to causes other than AIDS"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18216] "Epidemiology as it relates to infectious diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18217] "Establish appropriate infrastructure for the conduct of HIV research domestically and internationally."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18218] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18219] "National Research Service Award (NRSA) institutional training grants (T32) enable eligible institutions to develop or enhance predoctoral and postdoctoral research training opportunities for individuals, selected by the institution, who are training for careers in specified shortage areas of biomedical and behavioral research. The purpose of the NRSA program is to help ensure that highly trained scientists are available in adequate numbers and in the appropriate research areas and fields to carry out the nation's biomedical and behavioral research agenda. (National Research Service Award Institutional Research Training Grants, NIH Guide, Volume 23, Number 21, June 3, 1994)"                                                                                                                                                                                                                                                                                          
[18220] "In molecular biology, a recombination event in which a genetic element is inserted."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18221] "The Postdoctoral Intramural Research Awards Program provides new investigators with advanced training and an opportunity to conduct full-time research in a laboratory environment that is compatible with the interests of the participant.  IRTA Traineeships are established for the principle benefit of the participant and to provide opportunities for developmental training and practical research experience in a variety of disciplines related to biomedical research, medical library research and related fields."                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18222] "The office that oversees research efforts which take place on the NIH campus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18223] "The science concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals that have no spinal column. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18224] "Tissue and cells from the general category of the kingdom Animalia (multicellular animals) including those phyla whose members lack a notochord."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18225] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18226] "The biochemistry, including enzyme action, of lipids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18227] "The 'test tube' chemical reactions of lipids-not involving enzymes"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18228] "EBV latent membrane protein (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18229] "4B2; Clinical Health Services Research And Delivery; Health Services Grants; Low Prevalence"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18230] "The structure and biological function of lymphocytes in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18231] "The structure and biological function of macrophages"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18232] "Interdisciplinary field of study in which theoretical, computational, or mathematical research is applied to or motivated by biology."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18233] "The study of insects as they relate to human disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18234] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18235] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18236] "RAEB: Medicine applied to diseases that predispose to cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18237] "To provide the opportunity for promising medical scientists with demonstrated aptitude to develop into independent investigators, or for faculty members to pursue research aspects of categorical areas applicable to the awarding unit, and aid in filling the academic faculty gap in these shortage areas within health professions institutions of the country."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18238] "The metabolism of microbial life forms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18239] "The study of microorganisms with an emphasis on their role in the human disease process."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18240] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18241] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18242] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18243] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18244] "Health aid that is directed to minority groups."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18245] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18246] "The process of determining the sequence of purines and pyrimidines in nucleic acids and polynucleotides."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18247] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18248] "The process of determining the sequence of amino acids within a protein molecule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18249] "Studies of chromosome biology and behavior at the molecular level."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18250] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18251] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18252] "The study of viral processes at the molecular level.  Includes infection, replication, and expression of the viral genome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18253] "1.  The synthesis or transcription of messenger RNA.  2.  Reference to the translation of messenger RNA as a measure of its biological activity or expression.  Transcription or cytoplasmic presence does not necessarily indicate mRNA expression, e.g. masked maternal RNA present in embryos."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18254] "The physiology of muscle contraction"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18255] "The detection by physical, chemical, or biological means of an altered DNA sequence. Includes SSCP, DNA sequencing, hybridization, and reporter gene expression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18256] "The range of mutations that have occurred to a gene, or at a specific locus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18257] "The study of fungus in a nonclinical environment, ie not as a pathogen"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18258] "The National Cancer Program plans and coordinates the national cancer research program, encompassing the programs of the National Cancer Institute, related programs of the other research institutes, and other Federal and non-Federal programs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18259] "As the NCI's principal advisory body, the Presidentially-appointed National Cancer Advisory Board (NCAB) advises the NCI Director on issues related to the National Cancer Program and provides a second level of review for grant applications referred to NCI."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18260] "T-Series: Training Programs, P-Series: Research Program Projects and Centers, N-Series: Research Contracts"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18261] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18262] "RAEB: See SIC 70 (Neurofibromatosis). Also cell surface molecules such as fibronectin and glycosaminoglycans; neural crest differentiation; nerve growth factor; melanogenesis; malignant schwannomas; pheochromocytomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18263] "A subdiscipline of genetics with a focus on nerve cells and the nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18264] "Study of viruses which infect nerves."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18265] "National Research Service Awards (NRSA) are made to individual fellowship applicants selected for award as a result of national competition for research training in specified health-related areas.  The National Institutes of Health (NIH) awards NRSA individual postdoctoral fellowships (F32) to the most promising applicants to support full-time research training related to the mission of the NIH awarding components. Some specialized individual predoctoral fellowships (F31s and F30s) and Senior  Fellowships (F33s) are also provided under the NRSA. (NRSA Guide: Sections I and II)"                                                                                                                                                                                                                                                                                                                                                                                            
[18266] "A formal statement that invites grant or cooperative agreement applications in a well-defined scientific area to accomplish specific program objectives. The RFA indicates the estimated amount of funds set aside for the competition, the estimated number of awards to be made, and the application receipt date(s)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18267] "Not applicable when applying route of administration. FDA CDER (HL7) numeric code: 312"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18268] "The metabolism involving the synthesis of nucleic acids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18269] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18270] "Studies of carcinogens encountered through occupational exposure. The carcinogens can be of any type: chemicals, electromagnetic fields, UV, viruses, etc. Many of these agents may also be commonly encountered outside the occupational environment (e.g., UV) but in such cases they are not coded in this category; for farmers and sailors, UV is an occupational carcinogen. Epidemiologic studies will usually clearly identify occupational carcinogens but in experimental studies or analyses of carcinogenic mechanisms, a judgment must be made as to whether the primary means of exposure is occupational and thus requires selection of SIC 28; for example, one could be exposed to benzene in various settings, but the most frequent exposure risk would be occupational. For chemicals with which you are unfamiliar, consult the Merck Index to determine whether the chemical is used in manufacturing, agriculture, or other occupational setting."                           
[18271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18272] "Subdiscipline of pathology with a focus on vision and the eye."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18273] "The population of retired people, generally over 62"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18274] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18276] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18277] "Any method of quantitative or qualitative analysis that involves optics and/or the measurement of light."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18278] "A microbiology subdiscipline concerned with microorganisms of the buccal cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18279] "The chemistry of organometallic compounds (compounds having bonds between one or more metal atoms and one or more carbon atoms of an organyl group).  This concerns the synthesis, structure, reactivity, and the properties of such compounds, and the chemical transformations they undergo."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18280] "Other minorities not listed"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18281] "Other multiple areas not listed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18282] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18283] "Other types of training not listed"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18284] "The results for various forms of therapy for a given disease"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18285] "[Editor_Note:] part of Population Studies"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18286] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18287] "The program project grant is an institutional award made in the name of a program director for the support of a broadly based, long-term, multidisciplinary research program that has a well-defined central theme, research focus, or objective. The grant funds at least three interrelated projects and, often, core resources that support at least three projects at all times. Interrelationships and synergism among component research projects should result in greater scientific contributions than if each project were supported through a separate mechanism. The grant is based on the concept that projects closely related to a central theme can be conducted more effectively and efficiently through a coordinated, collaborative, multidisciplinary approach."                                                                                                                                                                                                                 
[18288] "Induction or development of a malignant disease(s) or condition(s) that results from retroviral activity or arises due to the immunocompromised state of an HIV infected individual. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18289] "Elucidate the pathogenic mechanisms involved in HIV-associated neurological diseases and neurobehavioral dysfunction. Enhance a bidirectional flow between basic and clinical observations and intervention programs on HIV-related complications and foster interdisciplinary collaborations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18290] "Induction or development of microbe-induced disease(s) in an immunocompromised HIV infected individual.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18291] "Induction or development of an organ or tissue disorder(s) that results from retroviral activity or arises due to the immunocompromised state of an HIV infected individual. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18292] "A specialty concerned with the nature and cause of disease as expressed by changes in cellular or tissue structure and function caused by tumors in animals (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18293] "The effect of insurance coverage on medical care and practices."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18294] "Nursing the ill pediatric and adolescent patient"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18295] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18296] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18297] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18298] "The toxicology of pesticides"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18299] "Molecular biology technique that facilitates cloning or identification of specific proteins or peptides with a specific antigenic, ligand or protein-binding, enzymatic, or other biological property.  It is based on the cloning of DNA within a phage coat protein gene so that the resulting protein is expressed as a fusion expressed on the surface of the phage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18300] "RAEB: the pharmacology of biologics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18301] "RAEB: The relation of a drug structure to its activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18302] "Analysis of the absorption or transmittance of light in the visible region of the electromagnetic spectrum by a specific compound.  By itself, this technique does not lead to the identification of a substance, but analysis of the spectrum (absorption versus wavelength) can help identify the presence of specific chromophores in the molecule.  When the identity of the compound is known, determination of the absorbance at a specific wavelength yields quantitative information about the material analyzed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18303] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18304] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18305] "Changing current and concomitantly magnetic fields"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18306] "Encoded by human PLCG2 Gene, 1265-aa 148-kDa Phospholipase C Gamma 2 is a crucial enzyme that generates DAG and IP3 second messengers in the transmembrane signaling of ligand-activated growth factor receptors. Containing a PI-PLC X-box catalytic domain, a PI-PLC Y-box catalytic domain, a C2 domain, a PH domain, 2 SH2 domains, and an SH3 domain, PLCG2 phospholipase activity increases upon phosphorylation on tyrosine residues following activation of growth factor and immune system receptors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18307] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18308] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18309] "Tissue and cells derived from plants"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18310] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18311] "1. The process of formation of poly(adenylic acid). 2. The covalent modification of a macromolecule (e.g., mRNA) by the formation of a polyadenylyl moiety covalently linked to the macromolecule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18312] "The study of synthesis and application of polymers.  Polymers are any of numerous natural and synthetic compounds of usually high molecular weight consisting of up to millions of repeated linked units, each a relatively light and simple molecule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18313] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18314] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18315] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18316] "Control of genetic expression past the level of messenger transcription."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18317] "Theoretical models before being tested clinically"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18318] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18319] "These fellowships will provide up to five years of support for research training leading to the Ph.D., or equivalent research degree; the combined M.D./Ph.D. degree; or other combined professional doctorate/research Ph.D. degrees in the biomedical or behavioral sciences.  These fellowships are for well-qualified students from minority groups found to be underrepresented in the biomedical and behavioral sciences in the United States. (Predoctoral  Fellowship Awards For Minority Students, NIH Guide, Volume 24, Number 5, February 10, 1995)"                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18320] "The intent of this Predoctoral Fellowship Program is to encourage students with disabilities to seek graduate degrees and thus further the goal of increasing the number of scientists with disabilities who are prepared to pursue careers in biomedical and behavioral research.  These fellowships will provide up to five years of support for research training leading to the Ph.D. or equivalent research degree; the combined M.D./Ph.D. degree; or other combined professional doctorate/research Ph.D. degrees in the biomedical or behavioral sciences. (Predoctoral  Fellowship Awards For Students With Disabilities, NIH Guide, Volume 24, Number 5, February 10, 1995)"                                                                                                                                                                                                                                                                                                              
[18321] "Identify appropriate domestic and international populations and develop infrastructure and collaborations with government, communities, and industry necessary for ensuring adequate performance of efficacy trials."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18322] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18323] "(prog-NOS-tik) A situation or condition, or a characteristic of a patient, that can be used to estimate the chance of recovery from a disease or the chance of the disease recurring (coming back)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18324] "These groups are composed of scientists, health professionals, industry representatives and lay advocates brought together to assess the state of our knowledge and identify scientific opportunity and need in such high priority areas of research as prostate cancer and breast cancer. NCI will use the Groups' recommendations to help set a national research agenda in these areas. (National Cancer Institute-Justification of Estimates for Appropriations Committees)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18325] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18326] "Analysis of protein components in a sample.  The most basic analysis involves determination of the mass or concentration of protein by any of a number of quantitative assays.  Increased level of detail in the analysis requires resolution of a mixture into its component proteins.  The characterization of a pure protein includes the determination of a number of its properties, among these, the molecular weight, isoelectric point, subunit composition, tryptic map, amino acid composition, amino acid sequence, hydrodynamics (s value, frictional coefficient, shape, aggregation state), thermodynamics (melting, folding, protein-protein interactions), and atomic structure (NMR, diffraction)."                                                                                                                                                                                                                                                                                
[18327] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18328] "The chemistry (synthesis, degradation, and modification) of proteins and peptides."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18329] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18330] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18331] "The action of enzymes, regulators, chaparones etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18332] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18333] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18334] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18335] "Vectorial transport of proteins across a cell membrane to the extracellular environment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18336] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18337] "The enzymes involved in the metabolism of proteins and amino acids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18338] "Protein synthesis occurs in the cell by translating the sequential codons in messenger RNAs into amino acid residues of a peptide chain.  This translation physically occurs in macromolecular complexes called ribosomes, pairing amino acid-carrying transfer RNA complexes with individual codons of the messenger RNA, transferring the elongating peptide to this tRNA-amino acid complex with formation of a peptide bond, releasing the previous tRNA, and translocating the messenger RNA to make the next codon available for pairing.  The process is then repeated until a termination codon is read and the peptide is released."                                                                                                                                                                                                                                                                                                                                                       
[18339] "Health education aimed at the general public"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18340] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18341] "PURA is a potent transactivator able to bind purine-rich DNA sequences (GAGA boxes), often found upstream of gene transcription start sites.  PURA is implicated in transcriptional control of many cellular genes, including MBP, FE65, and neuronal ACHR, as well as viral promoters for JCV and HIV-1.  PURA is also involved in cell growth control and interacts with hypophosphorylated RB1.  It interacts with large T-antigen and cellular protein YB-1 to activate JC viral DNA transcription.  PURA is also a single-stranded DNA-binding protein with specific affinity for a (GGN)n element present in several eukaryotic DNA replication initiation zones."                                                                                                                                                                                                                                                                                                                            
[18342] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18343] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18344] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18345] "The use of non-ionizing radiation such as X-rays to obtain internal images of the body"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18346] "RAEB: A particle which carries a positive or negative electrical charge. In plasma physics, this typically means an ionized atom or molecule, or an electron."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18347] "RAEB: Low level radiation carcinogenesis, mutagenesis, and biology, not diagnosis or therapy, unless the focus is on harmful side effects of these procedures (e.g. second tumors presumably resulting from radiation therapy of a previous tumor) or on basic interactions of radiation with biological molecules."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18348] "RAEB: Diagnostic or therapeutic use of non-ionizing radiation"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18349] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18350] "A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease of the bone. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18351] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18352] "A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease of the head and neck. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18353] "A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease of soft tissue. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18354] "A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease of the thorax and chest (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18355] "The study of the regulation of gene expression by nuclear receptors.  Includes the mechanisms by which receptors are themselves regulated."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18356] "Transduction of regulatory signals mediated by nuclear or cytoplasmic receptors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18357] "Antibodies produced by recombinant DNA techniques."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18358] "Undertake epidemiologic research to reduce or prevent the occurrence of OIs in HIV-infected persons."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18359] "The business of a regulatory agency"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18360] "The science concerned with drugs and their actions and uses in kidney biology and the treatment of kidney disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18361] "The medical science, and specialty practice, concerned with all aspects of disease of the kidney and general organs of reproduction and urination, but with special reference to the essential nature, causes, and development of abnormal conditions, as well as the structural and functional changes that result from the disease processes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18362] "The study of the enzymes and mechanisms involved in the repair of damaged DNA.  DNA repair involves the reconstruction of a continuous double-stranded DNA molecule without mismatch from a molecule containing a damaged region. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as \"dark repair\" because they do not require light.\" (from MSH98)"                                                                                                          
[18363] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18364] "The study of the total process by which organisms produce offspring. (Stedman, 25th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18365] "The study of those hormones, and their actions, which affect fertility and pregnancy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18366] "The science concerned with the normal processes of organismal reproduction."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18367] "To provide matching federal funds, up to 75%, for construction or major remodeling, to create new research facilities. In addition to basic research laboratories this may include, under certain circumstances, animal facilities and/or limited clinical facilities where they are an integral part of an overall research effort (C06). (from Grant Guidelines and Descriptions, NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18368] "A research contract differs from a grant or cooperative agreement awarded in response to an RFA with regard to the rules that govern them. Contracts must comply with the provisions of the U.S. Government's Federal Acquisition Regulations {FAR}. The FAR includes the forms and procedures used in the solicitation for and award of contracts, and identifies the level of Government oversight of performance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18369] "Develop and evaluate new laboratory assays, behavioral methods, and statistical techniques for epidemiologic studies. (FMB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18370] "P01 (Research Program Projects) support multidisciplinary or multifaceted research programs with a focused theme. P20 (Exploratory Grants) support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to the development of inter-disciplinary programs that offer potential solutions to problems of special significance to the mission of the NIH. P30 (Center Core Grants) support shared resources and facilities for categorical research by a number of investigators from different disciplines who provide a multidisciplinary approach to a joint research effort or from the same discipline who focus on a common research problem. P50 (Specialized Center Grants) support any part of the full range of research and development from very basic to clinical may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. (from NCI)"  
[18371] "The NIH is emphasizing the use of administrative supplements to attract underrepresented minorities into biomedical and behavioral research.  Funds are available for administrative supplements to existing grants for the support and recruitment of underrepresented minority investigators and students.  The aim of these supplements is to attract and encourage minority individuals to enter and pursue biomedical and behavioral research careers in areas within the missions of all the awarding components of the NIH by providing supplemental funds to certain ongoing research grants. (from Research Supplements For Underrepresented Minorities, NIH Guide, Volume 25, Number 3, February 9, 1996)"                                                                                                                                                                                                                                                                                
[18372] "The National Institutes of Health (NIH) and its awarding components have developed this initiative to extend opportunities to individuals with qualifying disabilities who are capable of entering or resuming research careers. Under this initiative, individuals with disabilities are encouraged to pursue biomedical research careers in areas within the mission of an NIH awarding component through supplemental awards to certain ongoing research grants. It is hoped that the plan to provide funding at several different stages in a research career will substantially increase the number of individuals with disabilities in biomedical research."                                                                                                                                                                                                                                                                                                                                  
[18373] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18374] "S03: Minority High School Student Research Apprentice Program (NCRR) -To provide meaningful experience in various aspects of health-related research in the expectation that some apprentices will decide to pursue careers in biomedical research.  S06: Minority Biomedical Research Support - MBRS -To strengthen the biomedical research and research training capability of ethnic minority institutions, and thus establish a more favorable milieu for increasing the involvement of minority faculty and students in biomedical research."                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18375] "Land set apart by the Federal government for use by American Indians or tribes. (WEBS98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18376] "The sharing of materials and data in a timely manner (from Genomic Resources For The Zebrafish, NIH Guide, Volume 26, Number 39, December 5, 1997)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18377] "Member of the nuclear receptor superfamily.  These proteins specifically bind retinoids which modulate several cell functions and especially inhibit the growth of tumor cells. Three subtypes (alpha, beta, gamma) of retinoic acid receptors (RARs) have been identified."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18378] "The study of RNA viruses from the family Retroviridae, which copy their genomes into DNA by action of reverse transcriptase and insert them into the host genome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18379] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18380] "Characterize the risk factors and mechanisms of HIV transmission in both domestic and international populations, with the goal of preventing transmission."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18381] "The folding of noncontiguous stretches of RNA to produce a more compact tertiary level of structure.  Distinct stretches of RNA may be found in different conformations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18382] "Used to denote the transcription of DNA into RNA.  The biochemical machinery includes sequence-specific DNA binding proteins that directly act in the regulation of the transcription process, other protein factors that participate in the assembly of the transcription complex, and RNA polymerase ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18383] "Interactions responsible for the assembly and stability of protein-RNA complexes.  Such complexes are of fundamental importance, affecting processes such as translation (ribosome), RNA processing (spliceosome), and DNA synthesis at telomeres (telomerase).  Protein structural motifs involved in RNA binding include beta sheet surfaces, alpha helices, and beta turns."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18384] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18385] "A rodent disease whose pathologic mechanisms are sufficiently similar to those of a human disease to serve as a model."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18386] "R43/44. grant type for Small Business Innovation Research"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18387] "Health and nursing care given to primary and secondary school students by a registered nurse. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18388] "The addition of science courses or lectures to a school's or institution's curriculum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18389] "The prioritizing of science projects by a government"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18390] "A class of publication in which original scientific work is described.  The format usually includes an introduction in which relevant concepts are identified and the experimental system under study is presented, a section describing the experiments that were performed to test a specific hypothesis and the results and observations that were obtained, a section in which the results are discussed relative to findings by other investigators and the current state of knowledge in the field, and a section describing the experimental methods and procedures in sufficient detail to enable the reproduction of the work by independent investigators."                                                                                                                                                                                                                                                                                                                               
[18391] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18392] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18393] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18394] "The study of the biochemistry related to sequencing macromolecules, e.g. nucleic acids, proteins, or long-chain carbohydrates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18395] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18396] "A visit from an oversite group to a site of a study or research for fact gathering, peer review, or compliance with regulations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18397] "The process by which normal skin cells are transformed into cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18398] "ASSIST builds on the research findings of previous NCI tobacco control trials that document the role of community involvement in decreasing tobacco use and controlling secondhand smoke. Conducted over a 7-year period (1991-1998), ASSIST focuses on helping smokers who want to quit, protecting nonsmokers from tobacco smoke, and discouraging the use of tobacco products among children. More than 1,000 organizations now participate in ASSIST coalitions in 17 states, with more than 91 million Americans (20 million smokers) participating. The NCI estimates that ASSIST will prevent approximately 1.2 million premature deaths due to tobacco use, including nearly 500,000 lung cancer deaths. (NCI-Questions and Answers About Finding Smoking Cessation Services)"                                                                                                                                                                                                              
[18399] "Establishing relationships with individuals who have similar social or professional interests for the purposes of expanding knowledge and professional/social interaction. (Glanz et al: Heath Behavior & Health Education, 1990)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18400] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18401] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18402] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18403] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18404] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18405] "Circular dichroism (CD), optical rotatory dispersion (ORD).  Linearly polarized light can be thought of as a combination of right and left-handed circularly polarized light of equal phase and amplitude.  ORD is the phenomenon observed when a substance exhibits a difference in the index of refraction of the right vs. left circularly polarized components, resulting in a change in the plane of polarization.  When an optically active substance contains a chromophore that absorbs in the optically active region of the spectrum, CD is observed, which involves the preferential absorbance of right or left-handed circular polarized light.  Both ORD and CD depend on the wavelength of the radiation and the structure of the molecule.  Structural elements of proteins that exhibit differences in CD/ORD include the alpha helix, the beta sheet, and random coil segments."                                                                                                  
[18406] "2C4b; Risk Assessment and Prevention; Information And Education/Preventive Services; General Public And Special Programs; Regional, state, and local"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18407] "Local and state health departments are part of the public health system that include administrative and service units concerned with the health of persons in specific jurisdictions, i.e., county or state. (Healthy People 2000, 1990)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18408] "The use of statistics to analyze and summarize data."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18409] "Differentiation of stem cells into specialized cells"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18410] "The metabolism of steroid compounds."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18411] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18412] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18413] "A government-wide program that promotes technology transfer by helping investigators form partnerships between the private and public sectors. It differs from SBIR in being somewhat less restrictive in the level of activity permitted for academic institutions. The STTR program is a set-aside program designed to support innovative research -- that has the potential for commercialization of the subject of the research --conducted cooperatively by a small business concern and a research institution. Innovation and the potential for commercialization are two of the review criteria considered in the scientific and technical merit evaluation process. At least 40 percent of the research project is to be conducted by the small business concern and at least 30 percent of the work is to be conducted by the single, \"partnering\" research institution."                                                                                                               
[18414] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18415] "Surgery on neonates"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18416] "Computer or Web-based programs that permit the primary care professional to screen, assess, and monitor the outcome of patient interventions or training/education programs for students."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18417] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18418] "1) Morphologic alteration of small T lymphocytes in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by interleukins, mitogens such as phytohemagglutinins, and by specific antigens. It may also occur in vivo, as in graft rejection and chronic myelogenous leukemia, or 2) the process that a normal T lymphocyte goes through when induced by a pathologic agent such as human T-lymphotropic virus 1 (HTLV-1) to become an adult T cell leukemia or other aggressive malignancy where neoplastic T cells apparently use IL-2 as an autocrine growth factor. (from MSH98 and from Fundamental Immunology, 3rd ed., William Paul, ed., Raven Press, NY 1993, p.768)"                                                                                                                                                                                                                                                                 
[18419] "Development of bone marrow-derived stem cells in the thymus through stages of positive selection under the influence of epithelial cells in the thymic cortex and negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction.  Thymic T cell precursors (thymocytes) progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor.  They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells.  (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                        
[18420] "The systematic classification of living things or organisms. Kingdoms of living organisms are divided into groups (taxa) to show degrees of similarity or presumed evolutionary relationships, with the higher categories being larger, more inclusive, and more broadly defined, the lower categories being The systematic classification of invertebrates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18421] "The systematic classification of bacteria."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18422] "The systematic classification of plants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18423] "The systematic classification of vertebrates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18424] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18425] "Putting forth explanations of biological event before experimentation"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18426] "The study of neoplasms of the thorax"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18427] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18428] "Bone marrow-derived stem cells in the thymus become educated to recognize complexes of self-major histocompatibility complex (MHC) molecules plus self-peptides in a process called positive selection under the influence of epithelial cells in the thymic cortex.  Positively-selected thymic T cell precursors (thymocytes) then progress through a process called negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction where self-reactive, and potentially autoimmunity-inducing, thymocytes are deleted.  Thymocytes simultaneously progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor.  They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells."                                                                                       
[18429] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18430] "Tissue that is not frozen or embedded in preservatives"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18431] "An identifying appellation signifying status or function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18432] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18433] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18434] "A quantitative analysis of a toxic substance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18435] "The treatment or medication that can be administered to a person who has been exposed to a toxic substance"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18436] "RAEB: study of the toxicology of biologics"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18437] "RAEB: toxicology of compounds other than those used for therapy"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18438] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18439] "Provide both domestic and international training in biomedical and behavioral research on HIV."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18440] "T14: Conferences--To provide the chairman of the training committee funds for operation of the review group.  T32: Institutional National Research Service Award -To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas. Also see National Research Service Award (NRSA) Stipend Increase.  T34: MARC Undergraduate NRSA Institutional Grants -To enable minority institutions to make National Research Service Awards to individuals selected by them for undergraduate research training in the biomedical and behavioral sciences.  T35: NRSA Short-Term Research Training -To provide individuals with research training during off-quarters or summer periods to encourage research careers and/or research in areas of national need."                                                                                                                              
[18441] "The control of gene expression at the level of RNA transcription."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18442] "Conditional (or inducible) gene knock-out. A transgenic technique.  A transgenic animal is constructed such that a gene of interest, or chromosome region, is flanked by recombination-signal sites (eg, loxP).  The animal is then crossed to one which carries the specific recombinase (eg, cre) under the control of a conditional, or tissue specific, promoter. Upon treatment of an inducer the recombinase is expressed, promoting recombination between the signal sites and the loss of the intervening gene or chromosome region. (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18443] "Passage or transfer, as of a disease, by blood transfusion from a donor individual to a recipient. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18444] "Passage or transfer, as of a disease, affecting recipients who suffer from hemophilia. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18445] "Passage or transfer, as of a disease, by intravenous injection with shared drug paraphernalia from a donor intravenous drug abuser to a recipient intravenous drug abuser. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18446] "Passage or transfer, as of a disease, to a recipient individual within or due to occupational circumstances. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18447] "Passage or transfer, as of a disease, to a recipient individual due to miscellaneous or not otherwise specified circumstances. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18448] "Passage or transfer, as of a disease, to a recipient unborn offspring in utero. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18449] "Passage or transfer, as of a disease, from a donor individual to a recipient during or as a result of sexual activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18450] "Induction of cancer in an individual by in utero exposure to a carcinogen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18451] "The use of labelled tracers for the elucidation of transport pathways."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18452] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18453] "Discover, develop, and evaluate improved strategies for the treatment and prevention of HIV-associated malignancies and extend our understanding of the risk factors for and pathogenesis of such malignancies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18454] "Develop strategies for assessing, preventing, and treating central and peripheral nervous system dysfunction in the course of HIV infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18455] "Improved understanding of the pathogenesis of these disorders can be applied to the development and evaluation of therapies for the treatment and prevention of serious HIV-associated complications, especially wasting syndrome and growth failure, as well as other disorders including hematologic, dermatologic, renal, metabolic, pulmonary, cardiac, endocrinologic, psychiatric, and oral manifestations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18456] "Tetracycline controlled transactivator (tTA).  The original description of a tetracycline-regulated gene expression system is based on two plasmids, one of which constitutively expresses a tetracycline-controlled transactivator protein (tTA), a fusion protein between the tetracycline repressor of E. coli and the transcriptional activation domain of the VP16 protein of herpes simplex virus. The second plasmid contains the gene to be regulated by tTA under the control of an inducible promoter which consists of seven copies of the tetracycline resistance operator (tetO). Since this original description, many modifications have been described. (from Gallia GL, Khalili K. Oncogene 1998. 16:1879-84)"                                                                                                                                                                                                                                                                     
[18457] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18458] "Mechanisms that prevent immune detection and elimination of tumor cells"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18459] "Interactions of the immune system and tumor cells"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18460] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18461] "The medical science, and specialty practice, concerned with all aspects of tumor development, growth, and metastasis, but with special reference to the essential nature, causes, and development of abnormal conditions, as well as the structural and functional changes that result from the tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18462] "RAEB: The second step in two-stage carcinogenesis: the conversion of an initiated (premalignant) cell to malignancy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18463] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18464] "The field of science that studies the biological effects of ultraviolet radiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18465] "This includes elderly, low-literacy, blue collar, and poor populations. Minorities per se are not included but often belong to one or more or the included categories.  Does not include rural."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18466] "The medical specialty concerned with the study, diagnosis, and treatment of cancer of the genitourinary tract."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18467] "Heritable changes in DNA nucleotide sequence caused by exposure to ultraviolet light (UV).  UV treatment of DNA results mostly in the formation of cyclobutane pyrimidine dimers and (6-4) photoproducts.  UV-damaged DNA interferes with DNA replication and transcription, and can lead to cell killing or mutagenesis if the damage is not repaired."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18468] "V-ABL is an ABL oncogene of Abelson's murine leukemia virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18469] "V-Ras-Ha is a transforming protein encoded by the v-Ras-Ha oncogene (or v-Ha-Ras) of Harvey murine sarcoma virus (Ha-MuSV)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18470] "V-Src is an oncogene of Rous Sarcoma Virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18471] "An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18472] "The genes that encode the outer structure that encloses the nucleocapsids of some viruses and may contain host material."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18473] "The use of biological techniques to study the spread and control of viral pathogens and viral disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18474] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18475] "The branch of science concerned with the means and consequences of viral transmission and generation of the components of biological inheritance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18476] "Delineate the cellular and molecular mechanisms associated with the viral immunopathogenesis of HIV-related immune dysfunction."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18477] "The study of animal viruses and the diseases they cause."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18478] "The study of adenoviruses and the diseases they cause."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18479] "The study of DNA viruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18480] "The study of papilloma viruses and the diseases that they cause."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18481] "The study of papova viruses and the diseases they cause."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18482] "The study of polyoma viruses and the diseases that they cause."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18483] "The study of those viruses that infect humans and the diseases they cause."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18484] "Research concerned with the origin, structure, development, growth, function, genetics, and reproduction of RNA viruses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18485] "The science concerned with the normal processes of sight."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18486] "The science of the relation between the physical organs of sight and the measured, quantitative attributes of the mental perception of a visual stimulus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18487] "Organizations that volunteer their services"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18488] "DNA sequences that form the coding region for a trans-activator protein that specifies rapid growth in human immunodeficiency virus (HIV). vpr is short for viral protein R, where R is undefined."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18489] "Histological techniques in which thin sections through the entire animal are used."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18490] "The production of genetically identical organisms by vegetative reproduction from a single cell.  The process includes the introduction of a nucleus from a differentiated cell into an enucleated egg, implantation of the egg into a female, and growth and delivery of the organism. The source nuclear material can be embryo-derived, fetus-derived, or taken from an adult somatic cell.  (from MSH98 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18491] "Nursing care specifically focused on the care of the adult female."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18492] "The use of nucleic acid oligomers to bind to a specific mRNA to deter protein production and halt a disease process."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18493] "1 or more networks, composed of health care provider organization researchers who will be capable of conducting studies of cancer epidemiology, treatment, and prevention and control. (from Cancer Research Network Across Health Care Systems, NIH Guide, Volume 26, Number 30, September 5, 1997)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18494] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18495] "Deceptive imprinting refers to a mechanism leading to a fixed state of immunity that fails to adapt to a changing pathogen and has lost the ability to discriminate antigen after the establishment of a strong primary immune response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18496] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18497] "Typically, the use of hybridization techniques to detect amplification or deletion of specific DNA sequences.  The hybridization signal of a specific sequence is compared to that of a reference sequence, usually one known to be present once per haploid genome. (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18498] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18499] "The U.S. legislature, consisting of the Senate and the House of Representatives. (American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18500] "The President of the United States of America."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18501] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18502] "One who defends, vindicates, or espouses a cause, by argument."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18503] "The NCI Board of Scientific Counselors comprised of leading scientists and members of the lay community, advises the Directors of the Intramural Division of the NCI and the Director and Deputy Director, NCI, on the matters concerning scientific program policy and the progress and future direction of research programs of each Division, including the evaluation of performance and productivity of each Division and staff scientists through periodic site visits to intramural laboratories, and evaluation and advice on the course of each Division's programs."                                                                                                                                                                                                                                                                                                                                                                                                                      
[18504] "The NCPB is intended to confront obstacles and address issues that arise in the prevention, control, diagnosis, and treatment of cancer. It meets at least three times annually to examine ongoing research, new technologies, issues arising in delivery of care, and problems faced in the Nation's battle against cancer. It serves as a common meeting ground for the many federal agencies that sponsor or directly conduct relevant work as well as state and local health authorities. The Board's most distinctive contribution, however, will be to render advice to the Nation in the area of policy and make recommendations to advance the Nation's effort against cancer. (from http://www.nci.nih.gov/admin/fmb/2001sigitems/cancoordination.html)"                                                                                                                                                                                                                                   
[18505] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18506] "Studies theoretical aspects of the biology of populations, particularly in the areas of ecology, genetics, demography, and epidemiology."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18507] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18508] "RNA degradation is a regulated cellular biochemical process that involves depolymerization of RNA macromolecules, which affects the RNA content of cells and regulates gene expression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18509] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18510] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18511] "Systems and reagents for the propagation of cells in tissue culture"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18512] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18513] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18515] "(meh-TAS-ta-sis) The spread of cancer from one part of the body to another. A tumor formed from cells that have spread is called a \"secondary tumor\", a ?metastatic tumor?, or a ?metastasis?.  The secondary tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases (meh-TAS-ta-seez)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18516] "Any subcellular or molecular event, process, or condition that produces a divergence from the usual wild-type, germline, or pre-existing condition in the primary sequence of a biological macromolecule. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18517] "Cancer-causing genes encoded in viral genomes.  Usually denoted v-onc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18518] "Any event, process, or activity that produces a deleterious alteration of DNA. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18519] "Addresses geographic variability in medical practice in the United States and the medical and nonmedical factors that create this variability ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18521] "Specimen; a bit of tissue or blood or urine that is taken or used for research purposes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18522] "Refers to the physical structures needed to conduct research as well as the basic services needed for support, eg shipping and receiving services, waste management, and utilities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18523] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18524] "A top level term of NCI Thesaurus"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18526] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18527] "Consists of three persons appointed by the President, who by virtue of their training, experience, and background are exceptionally qualified to appraise the National Cancer Program. Two of the members of the Panel are distinguished scientists or physicians. Members are appointed for three-year terms. Established by Congress, December 23, 1971."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18529] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18531] "Pathways and other molecular and cellular processes which can be manipulated in bacteria, the results of which can be extrapolated to human systems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18534] "Binds to and promotes degradation of p53 protein resulting in disruption of cell cycle regulation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18535] "Complexes with and inactivates Rb protein resulting in disruption of cell cycle regulation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18536] "Nucleotidyltransferases that catalyze the addition of deoxyribonucleotide residues to the end of a DNA.  EC 2.7.7.7 or EC 2.7.7.49"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18537] "(lair-in-JEK-toe-mee) A person whose larynx (voice box) has been removed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18538] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18539] "(noo-MAT-ik LAIR-inks) A device that is used to help a person talk after a laryngectomy. It uses air to produce a humming sound, which is converted to speech by movement of the lips, tongue, or glottis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18540] "(RAY-dee-o-AK-tiv) Giving off radiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18541] "(pa-THOL-o-jist) A specialist who evaluates and treats people with communication and swallowing problems. Also called a speech therapist."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18542] "(KAHN-tih-nent RES-er-vwar) A pouch formed from a piece of small intestine to hold urine after the bladder has been removed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18543] "(e-LEK-tro-LAIR-inks) A battery-operated device that makes a humming sound.  It is used to help a person talk after removal of the larynx (voice box)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18544] "(en-ter-o-STO-mul) A health professional trained in the care of persons with urostomies and other stomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18545] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18546] "Basic, Applied, Development codes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18547] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18548] "Colon, Rectum; having to do with the large intestine (colon) or the last portion of the colon that connects with the anus (rectum)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18549] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18550] "Assembly of virus core. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18551] "Examination of any part of the body for diagnostic purposes by means of roentgen rays, recording the image on a sensitized surface (such as photographic film). (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18552] "RAEB: Genetic engineering performed with the object of creating, modifying or otherwise enhancing a product whose manufacture is partly or entirely dependent on a biological process."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18553] "Budget category."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18554] "Functional category code."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18555] "RAEB: medicine related to non-malignant disease"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18556] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18557] "A funding category."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18558] "The MSH6 gene encodes the G/T Binding Protein (GTBP), which forms Mismatch-Binding Factor with MSH2. GTBP contains a PWWP domain, binds to G/T mismatches, is required for base/base and single-nucleotide insertion-deletion repairs, and increases the proficiency of two-four nucleotide insertion-deletion repair. ADP-bound MSH2/MSH6 binds to mismatched DNA, provoking ADP/ATP exchange and MSH2/MSH6 migration along the DNA backbone. DNA-bound, ATP-bound MSH2/MSH6 activates the repair machinery. MSH6 is part of the multisubunit BASC complex, which may sense abnormal DNA structures and regulate postreplication repair. Associated with colon, endometrial, and stomach cancers, the MSH6 Gene (MUTS family) at 2p16 is a cloned gene for Hereditary Non-Polyposis Colon Cancer. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                
[18559] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18560] "Government-wide programs to promote technology transfer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18561] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18562] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18563] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18564] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18565] "NCI.  The National Cancer Institute, part of the National Institutes of Health of the United States Department of Health and Human Services, is the Federal Government's principal agency for cancer research.  NCI conducts, coordinates, and funds cancer research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention, and treatment of cancer.  Access the NCI Web site at http://cancer.gov."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18566] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18568] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18569] "The Office of Special Populations Research was established in 1996 to advise the Director of NCI and provide a focal point for leadership and coordination on minority and other special populations research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18570] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18571] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18572] "The Journal of the National Cancer Institute publishes manuscripts that describe new findings of particular significance in any area relating to cancer, as well as associated news items, reviews, and opinion pieces.  The Journal endeavors to appeal to a broad, multidisciplinary audience.  Contents include: Peer-reviewed reports on major oncology studies from around the world; Editorials and commentary by leading experts on key articles and current controversies in cancer; The latest news from the oncology community, book reviews, and conference and position announcements. (from JNCI Information for Authors)"                                                                                                                                                                                                                                                                                                                                                             
[18573] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18574] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18575] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18576] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18577] "Formed to act as a central point of contact and NCI link to cancer advocacy organizations.  Recently rolled into the Office of Communications."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18578] "Merged with the Division of Clinical Sciences in January, 2001 to form the Center for Cancer Research"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18579] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18580] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18581] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18582] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18583] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18584] "Subcommittee of the Board of Scientific Counselors, NCI, which advises the Directors of the Intramural Division of the NCI and the Director and Deputy Director, NCI, on a wide variety of matters concerning scientific program policy and the progress and future direction of research programs of each Division, including the evaluation of performance and productivity of each Divison, the evaluation of performance and productivity of staff scientists through periodic site visits to intramural laboratories, and evaluation and advice on the course of each Division's programs."                                                                                                                                                                                                                                                                                                                                                                                                    
[18585] "Subcommittee of the Board of Scientific Counselors, NCI, which advises the Directors of the Intramural Division of the NCI and the Director and Deputy Director, NCI, on a wide variety of matters concerning scientific program policy and the progress and future direction of research programs of each Division, including the evaluation of performance and productivity of each Division, the evaluation of performance and productivity of staff scientists through periodic site visits to intramural laboratories, and evaluation and advice on the course of each Division's programs. (http://deainfo.nci.nih.gov/ADVISORY/bscfo.htm)"                                                                                                                                                                                                                                                                                                                                                   
[18586] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18587] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18588] "Department of Defense (DOD). According to the FY2004 Defense Appropriations Act, DOD is responsible for funding of several cancer research programs such as studies on breast, ovarian, and prostate cancer, leukemia, and myeloproliferative disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18589] "The Committee advises and makes recommendations to the Director, NCI, for the oversight and integration of various planning and advisory groups serving the broad programmatic and institutional objectives of the Institute. The Committee serves as the official channel through which the findings and recommendations emerging from these groups are submitted to the NCI. The Committee may consider the reports of the various review groups as informational, advisory, or as recommendations, and shall provide the NCI with assistance in identifying opportunities to be pursued within the areas of cancer research that cut across the intramural and extramural programs."                                                                                                                                                                                                                                                                                                             
[18590] "The Director's Consumer Liaison Group (DCLG) is a group of fifteen members of the cancer advocacy community who were convened to help NCI increase the representation of the cancer advocacy community on NCI advisory committees, and increase their involvement in program and policy development.  DCLG members will interact directly with the scientific community at NCI on a wide range of programs and issues. The DCLG will also help NCI to widen the pool of qualified consumer-advocates who can be called upon to serve on NCI advisory committees and other groups. (2/99)"                                                                                                                                                                                                                                                                                                                                                                                                           
[18591] "An instrument used to measure an event involving emission, absorption, or refraction of light."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18592] "A research technique used to demonstrate nucleotide sequence variations that occur in the same region of DNA between individuals within a species, or between alleles in an individual to detect mutations in various genes, such as oncogenes, tumor suppressor genes, or genes responsible for genetic diseases. The method detects different conformations adopted by partially denatured DNA fragments resulting from their specific nucleotide sequences under denaturing conditions. Denatured single-stranded DNA fragments are allowed to partially renature without formation of double-stranded DNA. The particular conformations adopted by each of the renatured fragments depend on each of their specific nucleotide sequences. The fragments are run on polyacrylamide gels to detect subtle changes in migration due to their particular secondary structures. Resulting fragment band in the gel will misalign if any point mutations are present to alter the conformation."      
[18593] "A variation of SSCP analysis in which the DNA fragments are generated by chain terminating sequencing reactions.  Can be more sensitive due to the increased number of fragments , only a small number of which might display an altered migration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18594] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18595] "Techniques and methods utilized to preserve biological material in an living state."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18596] "The utilization or development of computer programs to solve, analyze, understand or manage any simple or complex task."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18597] "This is an approach to modeling a protein structure based on an initial sequence alignment to a protein with a known 3D structure.  After evaluating and resolving structural irregularities in the initial model, it may be further refined using energy minimization and other procedures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18598] "The methods and tools used for DNA analysis and manipulation"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18599] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18600] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18601] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18602] "AIDS related research with a minimum of 20% (or $100,000) research efforts related to deaths of children under 1 year of age. (FMB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18603] "Mutagenesis where the mutation is caused by the loss of DNA sequences within a gene. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18604] "Molecular biology technique used to determine the 5' end or 3' end of a nucleic acid molecule, or the location of the junction between spliced molecules.  Used most commonly to determine the 5' end of RNA transcripts.  Based on the protection afforded an end-labeled DNA probe from nuclease S1 digestion after hybridization with a target molecule.  The length of the protected probe indicates the end or molecular junction of the target nucleic acid sequence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18605] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18606] "Luc Genes encode Luciferase, flavoprotein enzymes in certain marine crustaceans, fish, bacteria, and insects that catalyze bioluminescent oxidization of Luciferins to an electronically excited compound that emits energy in the form of light. The firefly enzyme is a valuable reagent for measurement of ATP concentration. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18607] "Social and economic factors that characterize the individual or group within the social structure. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18608] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18609] "The joining together of two or more nucleic acid molecules by the action of ligase"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18610] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18611] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18612] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18613] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18614] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18615] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18616] "In epidemiology, a rating scale for comorbidity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18617] "Occupations within the field of medicine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18618] "A set of events occurring in B lymphocytes following stimulation with cognate antigen.  Crosslinking the B cell antigen receptor (surface immunoglobulin) leads to increased expression of MHC class II molecules, exit from the resting state (G0) into the G1 phase of the cell cycle, and in the case of a strong antigenic stimulus, proliferation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18619] "New network dedicated to studying inherited predispositions to cancer.  Includes 8 centers and an informatics and information technology group.  It will integrate discoveries into medical applications and address psychosocial, ethical, legal and other implications related to inherited genetic susceptibility."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18620] "The objective is to examine the role of genes that regulate the metabolism of environmental carcinogens in prostate cancer etiology.  These genes include cytochromes P450 (e.g. CYP1A1, CYP2D6, and CYP2E1) and the mu or theta classes of the glutathione-S-transferases.  Three specific aims are proposed to accomplish this objective.  In Specific Aim l, the relationship of each of the candidate genes and the occurrence or age of onset of prostate cancer will be examined.  The relationship between multiple candidate genes and the occurrence or age of onset of prostate cancer will be examined in Specific Aim 2.  The interactions of multiple candidate genes, environments, and exposures will be examined in Specific Aim 3.  (from EGP Research Programs, PI: Timothy R. Rebbeck, University of Pennsylvania, R29_ES_08031_03)"                                                                                                                                             
[18621] "To stimulate the development of resources and pilot projects in human cancer genetics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18622] "International consortium of over 25 groups and multiple investigators pursuing collaborative research on the epidemiology of prostate cancer. The consortium was first promoted and supported by the NCI's Epidemiology and Genetics Program in 1995. Investigators are funded primarily by the NCI for their individual research projects (RO1s) while the National Institute for Human Genome Research contributes an intramural component. Current research focuses primarily on the discovery and characterization of prostate cancer susceptibility genes. Collaborations are established through communications and agreements with the participating groups."                                                                                                                                                                                                                                                                                                                                
[18623] "A neoplastic disease of a mouse with clinical features sufficiently similar to those of a human cancer to serve as a test system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18624] "Studying the origins, progression, and treatment of cancer in a non-mammalian organism"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18625] "The Diagnostic Imaging Program (DIP), of the Division of Cancer Treatment and Diagnosis (DCTD) solicits exploratory/developmental (R21) grants that articulate highly innovative research concepts in diagnostic cancer imaging to provide investigators with the initial resources required to accomplish feasibility and pilot testing of innovative ideas. The R21 mechanism will provide investigators at all career levels with a defined level of funding adequate for the initial feasibility testing of high risk/high impact concepts and, if the concepts are viable, for the generation of experimental preliminary data. This would render the investigators competitive for funding through the research project grant (R01) and/or First Independent Research Support and Transition (FIRST) (R29) award mechanisms, thus potentially leading to the establishment of new research programs in areas that might have previously remained unexplored."                                 
[18626] "Laser capture microdissection is a new technology developed in the Intramural Program to allow sampling of specific cells under direct microscopic visualization by a pathologist. A film is placed against the heterogeneous tissue and activated by a laser beam to capture only the cells of interest. Those cells are transferred to the film to provide a visual microscopic record of what was transferred, which can be analyzed for DNA, RNA, or protein.  The film upon which the cells are transferred is incorporated into the cap of a vial so that, when the transfer is done under a routine microscopic visualization, the microdissected material can immediately be put into a vial for processing. The system is integrated into a pathologist's microscope so that the cells are microdissected, transferred to the cap, and then rotated into a vial by a rotating arm in a hands-off operation. (from Cancer Genome Anatomy Project (CGAP) Update)"                            
[18627] "Provide a funding mechanism for developing and testing new technologies that underlie discovery in all aspects of cancer research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18628] "NCI established the Early Detection Research Network (EDRN) to identify and evaluate molecular biomarkers and technologies for earlier detection and risk assessment of all major cancers. The EDRN is a national network of academic and industry investigators with expertise in laboratory and clinical sciences, biostatistics, informatics, and public health."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18629] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18630] "Preclinical studies designed to improve cancer treatment; emphasis on discovery of new drugs and treatment strategies, selective targeting, development of new preclinical models, and understanding, preventing, and overcoming drug resistance.  NCI Cancer Activity: used for grant referral to programs)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18631] "The field of information science concerned with the analysis and dissemination of medical data through the application of computers to various resource aspects of health care and medicine.  Resources may include databases (drug structures, gene sequences, genealogical data, insurance records, tumor registries), software, cell or tissue banks, or other collections available for use in research. (from MSH98 and NCI/RAEB)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18632] "The goal of the National Cancer Institute's (NCI) Howard Temin Award is to bridge the transition from a mentored research environment to a National Cancer Institute independent research career for scientists who have demonstrated unusually high potential during their initial stages of training and development. This special award is aimed at fostering the research careers of outstanding, junior, basic, clinical, and behavioral scientists who are committed to developing research programs highly relevant to the understanding of human biology and human disease as it relates to the etiology, pathogenesis, prevention, diagnosis, and treatment of cancer."                                                                                                                                                                                                                                                                                                                    
[18633] "The Independent Scientist Award (ISA) (K02) provides support for newly independent scientists who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers.  This award is intended to foster the development of outstanding scientists and enable them to expand their potential to make significant contributions to their field of research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18634] "Initiative to bring together imaging experts from around the nation to perform multi-institutional clinical trials on diagnostic imaging tools related to cancer. (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18635] "A disease in a transgenic animal with pathologic mechanisms sufficiently similar to those of a human disease for the animal disease to serve as a model."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18636] "The alpha, beta, and gamma subunits (or beta-gamma dimers) of heterotrimeric guanine nucleotide binding (G) proteins are intracellular membrane-associated proteins activated by various receptors (e.g., beta adrenergic).  They serve as transducers of the receptor-initiated response linked to intracellular elements, such as enzymes, that generate second messengers to initiate an effect.  These proteins have a high affinity for guanine nucleotides and hence are named \"G\" proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18637] "G beta-gamma dimers associate with the alpha subunit to comprise heterotrimeric G proteins.  This dimer stimulates various, and sometimes opposing, cell signaling events in response to ligation of a G protein coupled receptor, such as the beta-adrenergic, adenosine, dopamine, LTB4, and PGE2 receptors, among many others."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18638] "Human G(i) Alpha Proteins (G-Alpha 1 Family) are 40-kDa guanine nucleotide-binding alpha protein subunits of heterotrimeric G protein transducers (alpha, beta, gamma) in transmembrane signaling systems involved in hormonal regulation of adenylate cyclase. Containing virtually identical/similar beta and gamma chains, G proteins are most distinguished by alpha chains. G(i) proteins (alpha(i) subunit) inhibit cyclase in response to beta-adrenergic stimuli. Specific alpha chain regions appear to interact with guanine nucleotides, receptors, effector enzymes, and G protein beta-gamma complex. G proteins that inhibit adenylate kinase and regulate other plasma membrane enzymes are substrates for pertussis toxin. (NCI)"                                                                                                                                                                                                                                                   
[18639] "the alpha subunit of the G(q) class of heterotrimeric G proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18640] "The alpha subunit of the G(12/13) class of heterotrimeric G proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18641] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18642] "The field of knowledge, theory, and technology dealing with the collection of facts and figures, and the processes and methods involved in their manipulation, storage, dissemination, publication, and retrieval. It includes the fields of COMMUNICATION, PUBLISHING, LIBRARY SCIENCE and informatics. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18643] "Part of the Division of Cancer Prevention.  Develops programs to improve clinical oncology in community settings and coordinates community oncology program activities with the activities of other research programs of the National Cancer Program; Promotes interaction between community oncologists and regional or national clinical cooperative groups; Stimulates psychosocial and physical rehabilitation research; Develops and conducts research on the management of cancer pain; develops research in the area of supportive care for patients and families; Studies the impact of cancer control programs on the community; and Conducts preliminary Phase II cancer control) studies of education, attitudes, and behavior of physicians, nurses, and other health professionals to serve as the basis for subsequent cancer control studies."                                                                                                                                       
[18644] "Part of the Division of Cancer Prevention and Control.  develope a research and applications program to support public health agencies in their cancer control efforts.  regularly and systematically assess community health needs, develop comprehensive public health policies based on the use of scientific knowledge, and assure the provision of services necessary to meet agreed-upon goals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18645] "This term is used as a form filler when there is no appropriate Immunology term available."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18646] "Cytochrome P450 2D5 is a rat liver ER membrane-bound heme-thiolate monooxygenase, involved in an NADPH-dependent electron transport pathway that oxidizes various compounds, including steroids, fatty acids, and xenobiotics.  Expression is induced in liver and other tissues by drugs, pesticides, and carcinogens."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18647] "Family of non-receptor protein tyrosine kinases similar to the syk protein (spleen tyrosine kinase) containing two SH2 (src homology 2) domains. They play essential roles in a variety of immune and non-immune cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18648] "Members of the tumor necrosis factor receptor (TNFR) family play a key role in regulating the immune response to infection.  They are cell-surface proteins that interact with a corresponding TNF-related ligand family. The receptors share homology in the extracellular domain, which contains 3 to 6 cysteine-rich pseudorepeats, but are generally not related in their cytoplasmic regions. However, the intracellular domains (ICDs) of TNFR family members TNFR1 and FAS/APO1/CD95, which can activate apoptotic cell death, do have a region of homology in an oligomerization interface known as the death domain. (from OMIM 603366)"                                                                                                                                                                                                                                                                                                                                                   
[18649] "A technology used for preclinical research as an alternative to some animal testing.  Micrometer-thin slices of various organs are incubated with various experimental compounds for assays involving toxicology, absorption, distribution, and metabolism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18650] "A category used for classifying sources of research reagents not obtained through academic institutions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18651] "A category used for classifying sources of research reagents obtained through academic institutions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18652] "A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18653] "Blue-Collar Group; refers to workers doing skilled or semi-skilled manual labor.  A traditionally underserved population."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18654] "Epidemiological factors are the identifiable and quantifiable things which contribute to the establishment and transmission of disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18655] "RAEB: Research to successfully transfer an organ from one individual to another of the same or a different species."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18656] "The medical science, and specialty practice, concerned with all aspects of disease, but with special reference to the essential nature, causes, and development of abnormal conditions, as well as the structural and functional changes that result from the disease processes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18657] "This term is used as a form filler when there is no appropriate Parasitology term available."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18658] "Mutations that result in the insertion of one or more nucleotides into a wild type DNA sequence.  Can result in a frame shift in the coding sequence of a gene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18659] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18660] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18661] "RAEB: Use for nurses as independent or semi-independent care providers: providing patient instruction, conducting quality of life evaluations, serving as nurse-practitioners, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18662] "Fetal Thymic Organ Culture.  A cell culture system where fetal thymic cells are grown in vitro."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18663] "Research animal models that do not include mice, rats, etc, but that might include non-human primates, cats, dogs, and others."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18664] "Biological field of study concerned with the analysis of similarities and differences in specific traits between different species.  Comparative studies can be utilized to gain insight into the function of specific gene products and the mechanism of particular processes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18665] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18666] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18667] "A cell-separation technique where magnetizable microspheres or beads are first coated with monoclonal antibody, allowed to search and bind to target cells, and are then selectively removed when passed through a magnetic field. Among other applications, the technique is commonly used to remove tumor cells from the marrow of patients who are to undergo autologous bone marrow transplantation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18668] "A bioassay used in the detection of interleukin-2 (IL-2) or interleukin-4 (IL-4) in the supernatants of in vitro-stimulated cells.  It relies on the IL-2- or IL-4-dependence of a cytotoxic cell line (CTLL-2) for in vitro proliferation, and the measurement of the growth of the these cells is usually determined by tritiated-thymidine incorporation pulsed into the CTLL-2 culture 8-12 hours immediately prior to harvesting the CTLL-2 cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18669] "Any apparatus which makes use of hollow fiber technology to increase the yield of surface area-dependent processes, such as dialysis and cell culture of attachment-dependent cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18670] "The science concerned with the normal vital processes of animal and vegetable organisms, especially as to how things normally function in the living organism rather than to their anatomical structure, their biochemical composition, or how they are affected by drugs or disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18671] "A demographic parameter indicating the amount of earnings made by a family."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18672] "a demographics parameter useful for identifying socio-economic groups."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18673] "This term is used as a form filler when there is no appropriate Statistics term available."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18674] "Allowing establishment of infection or acceptance of graft material."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18675] "The situation where a person has survived a disease for years"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18676] "Tissues which are indefinitely maintained in a viable state at extremely low temperatures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18677] "Cells which are indefinitely maintained in a viable state at extremely low temperatures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18678] "The cells taken from a tissue source, and their progeny, grown in culture before subdivision and transfer to a sub culture. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18679] "Occupations of medical personnel who are not physicians, and are qualified by special training and, frequently, by licensure to work in supporting roles in the health care field. These occupations include, but are not limited to, medical technology, physical therapy, physician assistant, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18680] "progression of T cell precursors in the thymus through many stages of maturation.  These stages include regulated expression of the alpha and beta (or gamma and delta) chains of the T cell receptor, expression of both CD4 and CD8 molecules (double positive stage), down regulation to a single positive stage (CD4 or CD8), as well as allowing those thymocytes to die which are unable to bind to self MHC molecules (death by neglect), selecting those thymocytes with T Cell Receptors that are able to bind to self MHC molecules with moderate affinity (positive selection), and deleting those thymocytes having T Cell Receptors that bind with high affinity to self MHC (negative selection), before allowing mature T cells to emigrate to the periphery."                                                                                                                                                                                                                       
[18681] "The science concerned with the various phenomena of immunity and induced sensitivity associated with the mother and fetus in gesticulating organisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18682] "A molecular biology research technique whereby a protein is engineered to contain signals which will target it to a specific subcellular location."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18683] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18684] "Technique for making and testing many complex materials in parallel: computer guided synthesis in which all possible combinations are made. Combinatorial synthesis is not random, but systematic and repetitive, using sets of chemical \"building blocks\" to form a diverse set of molecular entities.  Initial sythesis is usually made on a solid substrate. The technique lays down the materials in a checkerboard arrangement, as thin squares arranged in a grid.  Scientists use combinatorial chemistry to create large populations of molecules, or libraries, that can be screened efficiently en masse."                                                                                                                                                                                                                                                                                                                                                                              
[18685] "Branch of chemistry concerned with the synthesis of organic compounds.  It studies and develops schemes and reagents to synthesize specific classes of organics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18686] "Biological differences between normal and cancer cells.  Studies use mechanistic approaches to explore tumor cell biology and tumor progression at the molecular and cellular level, and to examine cell-cell and cell-matrix interactions at the macromolecular level in whole tissues.  Included is the study of the pathology and biology of solid tumors and tumor-bearing animals, chimeric, transgenic, and knock-out animals.  Research focused on the development of technologies to facilitate these studies is included."                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18687] "Pertaining to the fastest computers"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18688] "Modifications of primary RNA transcripts including: splicing, cleavage, base modification, capping and the addition of poly A (mRNA) or CCA (tRNA) tails. The primary transcript is the RNA molecule containing the exact sequence of bases (with U substituting for T in DNA) found in the nontemplate strand of transcribed DNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18689] "Institutions with an organized medical staff for the medical care, treatment, and cure of the sick and wounded, for the study of disease, and for the training of physicians, nurses, and allied health personnel."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18690] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18691] "The CHTN specializes in the prospective procurement, preservation and distribution of human tissues for research. Trained personnel coordinate the retrieval, preservation and delivery of specimens obtained from surgical resections and from autopsies.This resource provides normal, benign, pre-cancerous and cancerous human tissue to the scientific community for basic and developmental studies in many areas of cancer research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18692] "Advises the Director, National Cancer Institute (NCI), and the Director, Division of Extramural Activities, regarding research grant and cooperative agreement applications, contract proposals and concept review relating to basic and clinical sciences, and applied research and development programs of special relevance to the National Cancer Institute.  Members and Chairs will be selected on an \"as needed\" basis in response to specific applications, proposals or proposed solicitations to be reviewed.  Established by the Director, NCI, September 29, 1995. Currently authorized under 42 U.S. Code 284 (c)(3), Section 405(c)(3) of the Public Health Service Act, as amended. The Panel is governed by the provisions of Public Law 92-463, as amended (5 U.S.C. Appendix 2)."                                                                                                                                                                                               
[18693] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18694] "One of the purinergic P1 receptors that prefers adenosine to other endogenous purines."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18695] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18696] "The DCEG Intramural Research Award (IRA) is a new competitive funding mechanism to encourage exciting interdisciplinary projects that are innovative and cross the usual organizational boundaries. IRA recipients are recognized for their creative ideas and scientific skills in advancing the goals of the National Cancer Institute. Features of the IRA program include the following: Only Principal Investigators (PIs) are eligible to receive an IRA, although scientific collaborators may include non-PIs; Priority will be given to collaborative projects that are innovative and have potential for significant scientific or public health impact, including development of resources to facilitate population-based research (e.g., creation of a novel database or research model). Starting with FY1999 Pre-and Post-doctoral fellows became eligible for DCEG Intramural Research Awards."                                                                                      
[18697] "Research funded as a result of an institute set aside of dollars for a specific scientific area. Institutes solicit applications using research initiatives (RFAs for grants, RFPs for contracts). Targeted research applications are reviewed by chartered peer review committees within institutes. The opposite of Investigator-initiated research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18698] "The specific subdivisions in a classification scheme of funding activities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18699] "A funding category."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18700] "Use of ultrasound for imaging or diagnostic purposes. Employs frequencies ranging from 1.6 to 10 megahertz. (DCTD-DIP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18701] "This imaging technique returns information about the mechanical properties (feel) of tissues by combining MRI with ultrasound.  A properly equipped MRI machine captures a cross sectional image of the sound waves, produced by ultrasound techniques, which are then processed by computer to produce an image showing the hardness or elasticity of tissues within the cross section."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18702] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18703] "The spectroscopic analysis of light reflected from a polished sample.  The peaks of reflectance/transmittance occur in the same spectral region where the sample absorbs light.  In near infrared (IR) reflectance/transmission spectroscopy (NIRS), the reflectance signals result from bending and stretching vibrations in molecular bonds between carbon, nitrogen, hydrogen, and oxygen. (from FRTR Field Sampling and Analysis Technologies Reference Guide (online))"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18704] "Simultaneous use of more than one imaging technique."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18705] "A type of photography in which images can be viewed on a computer screen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18706] "Imaging methods not listed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18707] "Regulation of metabolic pathways"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18708] "Nursing care and research focused on populations with chronic disorders."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18709] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18710] "The growing of microbes in test tube or petri dish type environments"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18711] "DNA sequence errors introduced via DNA replication."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18712] "The application of engineering and mathematical principles to electrical problems"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18713] "The metabolism of nucleic acids and their components."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18714] "Any bioassay using a nude mouse."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18715] "Population-based studies that describe trends and associations between risk factors, habits, and a specific chronic disease, such as cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18716] "Population-based research studies that assess associations between tobacco use, behavioral and biological factors, and cancer.  (NCI/TRIP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18717] "Federal, state, or local programs that provide supplemental food assistance, e.g., Farmer's Market Coupon Program, Commodity Foods Program, Health Start; Women, Infant, & Children (WIC) Program. (NCI: 5 A Day Program)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18718] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18719] "A function, activity, or process involving the physical interaction between a virus or viral particle and a cell membrane. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18720] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18721] "Ubiquitin is a family of widely distributed proteins found in all eukaryotes that contain a highly conserved sequence of 76 amino acids identical in organisms from humans to insects. It participates in diverse cellular functions by conjugation to other proteins through its carboxy terminus. Ubiquitination is associated with many highly regulated biological events including protein degradation, chromatin remodelling, heat shock, cell cycle progression, differentiation, antigen presentation, retrovirus assembly, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis. Protein ubiquitination regulates the half-lives of many proteins by targeting them for degradation. Newly discovered families of ubiquitination and deubiquitination enzymes participate in these processes. Ubiquitination enzymes may provide new therapeutic targets and ways of intervention in many human diseases."             
[18722] "Energetics and biophysical mechanisms of DNA higher order structure"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18723] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18724] "Proliferation of blood vessels in a tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18725] "A molecular biology technique used to detect the interaction of a DNA binding protein with its cognate binding sequence.  Labeled DNAs were reacted with crude cell extracts and the complexes are run through a non-denaturing polyacrylamide gel.  The migration of the labeled DNA through the gel will be slower by being bound.  This shift in electrophoretic mobility indicates functional binding between the protein and the DNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18726] "A procedure used in mass spectrometry analysis. Means of delivering nonvolatile analytes into the gas phase for mass analysis. Best used on molecules which are charged in solution or readily accept a charge. Particularly well suited to the analysis of biomolecules. Can be used to probe tertiary structure and non-covalent interactions (from NCSU Mass Spectrometry Facility web site)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18727] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18728] "The efforts by the host to reject a tumor, and the mechanisms by a tumor to evade recognition by the immune system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18729] "A nursing specialty devoted to control and elimination of nosocomial infection risk in a clinical setting.  They do this through risk assessment, risk management, and staff education."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18730] "An interdisciplinary study dealing with the transmission of messages or signals, or the communication of information. Information theory does not directly deal with meaning or content, but with physical representations that have meaning or content. It overlaps considerably with communication theory and cybernetics. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18731] "Phenomena originating at the interface of material"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18732] "Relatively permanent change in behavior that is the result of past experience or practice. The concept includes the acquisition of knowledge. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18733] "The social institution involving legal and/or religious sanction whereby men and women are joined together for the purpose of founding a family unit, which consists of parents and children."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18734] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18735] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18736] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18737] "Elucidation of anabolic and catabolic pathways using labelled molecules or precursors. (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18738] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18739] "Provide a high level of professional nursing care with a special emphasis on the care of individuals with neurological diseases/diagnoses, such as stroke (CVA), brain injury, or spinal injury."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18740] "No definition provided; unspecified."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18741] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18742] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18743] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18744] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18745] "Use of conscious or unconscious strategies or mechanisms in adapting to stress (from PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18746] "the ability to nonspecifically stimulate the immune response."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18747] "1. The act of mixing; mixture. 2. The compound formed by mixing different substances together.  3. That which is mixed with anything. (ARTFL Project: Webster Dictionary, 1913)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18748] "Growth and reproduction of B-lymphocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18749] "Malignant transformation and proliferation of B lymphocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18750] "The unregulated growth of cancer cells insofar as growth control and contact inhibition."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18751] "Control of the rate or manner of occurrence of the complex series of phenomena occurring after division and before death of cancer cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18752] "A gene proposed to have a primary role in a disease, based upon its known function in other organisms or model systems or based upon its physical proximity to markers linked to a genetic disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18753] "The sum of the chemical and physical changes occurring in tissue and resulting in biodegradation of any cancer-producing substance or organism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18754] "Failure of a cancer to shrink after treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18755] "The natural or acquired ability of an organism to maintain its immunity to or to resist the effects of a cancer causing agent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18756] "The study of the energy changes involved in physical and chemical reactions within a cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18757] "The directional growth of a cell toward or away from a stimulus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18758] "Processes that gather and package the extended individual filamentous replicated interphase chromosomes into compact visible nuclear genetic structures in preparation for meiotic or mitotic cell division. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18759] "Centrifuge through a gradient until a substance reaches equilibrium"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18760] "A type of footprinting technique used to define the location of protein-nucleic acid contacts at the base pair level in nucleic acids.  It utilizes nucleic acids treated with a chemical in such a way that only a fraction of the nucleotides are chemically modified.  The chemically modified nucleotides that interfere with protein-nucleic acid complex formation can be identified by fragmentation and electrophoretic analysis of the DNA isolated from the complexes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18761] "The structure formed by two or more compounds."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18762] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18763] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18764] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18765] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18766] "Biosynthesis and catabolism of nucleic acids and their subunits"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18767] "The incorporation of minerals and electrolytes in coenzymes and gradients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18768] "Biosynthesis and catabolism of lipids, lipoproteins, and other membrane constituents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18769] "Biosynthesis and catabolism of proteins and their subunits"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18770] "Molecular recognition, the analysis of protein-protein or protein-ligand interactions by computational (molecular modelling) techniques.  Of particular interest in the pharmaceutical industry for rational structure-based drug design."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18771] "The lipid bilayer structure of membranes, associated proteins and how it relates to the function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18772] "Genes that encode proteins of the major histocompatibility complex, class II, DR beta."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18773] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18774] "Transport of drugs out of a cell.  A mechanism of drug resistance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18775] "Any subcellular or molecular event, process, or condition involved in translocation of a drug from one site or compartment to another. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18776] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18777] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18778] "The transport of material in and out of the nucleus through the nuclear membrane."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18779] "The point in G1 at which cells become committed to enter S phase and initiate DNA replication."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18780] "Sequence-specific DNA-binding proteins that recognize cis-elements with the core sequence GATA (or TATC)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18781] "Genetic programing is a method for obtaining an optimal programming algorithm.  Thousands of randomly created programs are progressively evolved over time using an evolutionary search based on the principle of survival of the fittest.  Mechanisms include the equivalent of recombination, mutation, duplication, deletion, etc. (from http://www.genetic-programming.org)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18782] "Exposure to DNA-damaging agents and subsequent energy expenditures by a cell to repair DNA damage.  Genotoxic stress elicits biochemical responses that either enhance cell survival or lead to cell death. These biochemical responses include DNA-damage-inducible repair and increasing expression of a variety of proteins by both transcriptional and post-transcriptional mechanisms.  Genotoxic stresses frequently activate signal transduction pathways that originate in the cell membrane or cytoplasm, triggering similar phosphorylation cascades to those induced by the activation of cell-surface receptors."                                                                                                                                                                                                                                                                                                                                                                       
[18783] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18784] "Dioxins are potent mammalian carcinogens and toxins affecting liver, skin, and immune and reproductive systems. N-myristoyltransferase 2 (NMT2) is one of the later dioxin-inducible genes. NMT2 and induced protein myristoyltransferase activity are direct responses to carcinogen exposure. Because inappropriate protein NH(2)-terminal myristoylation appears to play a role in carcinogenesis, induction of NMT2 may play a central role in dioxin carcinogenicity. (from Cancer Res 2001;61:8534-9)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18785] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18786] "The fitting of data to multivariable deterministic or statistical models; extraction of the number of independent parameters that contribute to the observable value of a function; the execution of an experimental test or procedure in which multiple parameters are monitored simultaneously."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18787] "Transport of messenger RNA from its nuclear site of transcription to the cytoplasm, where the message is translated into protein by ribosomes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18788] "Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated leukocytes or macrophages. Specific assays have been developed to estimate levels of migration inhibitory factor, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18789] "Reference to a chemical group or moiety that can complex or chelate a metal ion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18790] "The processes which result in cancers in the liver."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18791] "The study of the processes by which normal cells are transformed into cancer cells by metals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18792] "Posttranslational modification of proteins targeted for membranes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18793] "The study of the protoplasmic boundary of all cells that controls permeability and may serve other functions through surface specializations; e.g., active ion transport absorption by formation of pinocytotic vesicles; receptor-mediated antigen recognition, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18794] "Production of a new growth or growths in the mammary gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18795] "Encoded by human H2AX Gene (H2A Family) and expressed unlinked to replication in G1 and S-phase, 142-aa basal Histone H2AX has a unique conserved C-terminal sequence, QASQEY. NBS1/phospho-H2AX (gamma-H2AX) associate with irradiation-induced and V(D)J-induced DNA double-strand breaks. In pre-thymocytes, NBS1/gamma-H2AX form at RAG1-mediated TCRA V(D)J cleavage sites. NBS1/gamma-H2AX facilitate AID-dependent DNA break repair in G1 cells undergoing Ig heavy-chain constant region class switch recombination. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                           
[18796] "HL-60 is a promyelocytic cell line derived by S.J. Collins, et al. Peripheral blood leukocytes were obtained by leukopheresis from a 36-year-old Caucasian female with acute promyelocytic leukemia. The cells resemble promyelocytes. In vitro the cells can be induced to differentiate terminally into granulocyte-like cells or monocyte/macrophage-like cells, depending on the inducing agent. This cell line has been used as a model for human myeloid cell differentiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18797] "A DNA-binding and thermostable low-molecular-weight E. coli protein that resembles eukaryotic histones.  Acts as a cofactor in transcriptional repression. (from IRB summaries)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18798] "A specialty concerned with the nature and cause of human disease as expressed by changes in cellular or tissue structure and function caused by the disease process. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18799] "The transformation of a cell or cell population from a pre- or non-malignant condition to a malignant condition. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18800] "The continuous cell line K-562 was established by Lozzio and Lozzio from the pleural effusion of a 53-year-old female with chronic myelogenous leukemia in terminal blast crises. The K562 line is composed of undifferentiated blast cells that are rich in glycophorin and may be induced to produce fetal and embryonic hemoglobin in the presence of hemin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18801] "The circulation of white blood cells from the blood stream to tissues or secondary lymphoid organs, to the lymphatics, and back to the bloodstream via the thoracic duct."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18802] "Differentiation of keratinocytes to the fully differentiated keratinocyte phenotype."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18803] "Groups made up of volunteers"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18804] "Development of a new technology through the feasibility-testing stage to the level of a robust experimental or analytical tool. Development and maintenance of specialized specimen resources to facilitate basic and diagnostic cancer research, including tissue banks, tissue procurement, networks, and DNA banks.  Development of new tissue processing techniques and new reagents to better preserve critical molecular components to facilitate cancer diagnostic research.  Informatics support of tissue resources and diagnostic cancer research. (from Guide for Applicants: Genome Research Resource Grants (P41), Draft 1/24/95)"                                                                                                                                                                                                                                                                                                                                                     
[18805] "Mechanisms of mass communication"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18806] "For the lung, the act or process of natural progression in physical and physiological maturation from a previous, lower, or embryonic stage to a later, more complex, or adult stage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18807] "Medical science dealing with the study of immunity to diseases caused by microorganisms such as bacteria, viruses, or fungi. (from PSY94)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18808] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18809] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18810] "The exposure to potentially harmful agents in the environment or to work-related environmental factors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18811] "1A3; Basic Science Research (includes vaccine and chemotherapy development); Biomedical Research; Blood/Blood products (basic research and product development)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18812] "Biological processes that involve adding/removing chemical moieties to/from DNA, including methylation, phosphorylation, dephosphorylation, etc. occurring either in vivo or in vitro."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18813] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18814] "The branch of nucleic acid biochemistry concerned with the properties and actions of enzymes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18815] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18816] "A measure of the genetic difference between individuals or organisms.  It is a factor in determining if transplants are likely to succeed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18817] "This term is used as a form filler when there is no appropriate Toxicology term available."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18818] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18819] "Suspensions of killed or attentuated microorganisms (bacteria, viruses, or rickettsiae), or of antigenic proteins derived from them, administered for the prevention, amelioration, or treatment of infectious diseases or cancer. RAEB: Any aspect of vaccine research, development, testing, etc., for diseases other than AIDS. A vaccine must involve the administration of an antigen to induce an active and specific immune response. Induction of passive immunity does not constitute a vaccine although the term is sometimes misused for this process."                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18820] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18821] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18822] "The Specialized Programs of Research Excellence (SPOREs) established by NCI to promote interdisciplinary research and to speed the bi-directional exchange between basic and clinical science to move basic research finding from the laboratory to applied settings involving patients and populations. The goal of the SPORE program is to bring to clinical care settings novel ideas that have the potential to reduce cancer incidence and mortality, improve survival, and to improve the quality of life. SPOREs are funded through specialized center grants (P50s)."                                                                                                                                                                                                                                                                                                                                                                                                                       
[18823] "Non-Fed. Govt companies who contract to do specific work for the Fed Govt thru the official Contracting process."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18824] "Document type: Materials intended to educate the lay public in all aspects of cancer information"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18825] "Jobs available at NCI"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18826] "A printed or electronic document with spaces to be filled out."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18827] "Someone applying for financial support from NCI to do research, training, or other work"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18828] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18829] "Document type: The introductory page of a website; its navigational starting point"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18830] "Collaboration by NCI with industry (usuallly pharmaceutical) for cancer research"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18831] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18832] "Document type: Hyperlinks in documents"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18833] "Document type"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18834] "RAID is a new program designed to facilitate translation to the clinic of novel, scientifically meritorious therapeutic interventions originating in the academic community. It will do this by making available to the academic research community, on a competitive basis, NCI resources for the pre-clinical development of drugs and biologics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18835] "Document type (funding opportunity): a PA or RFA not requiring clearance at the NCI Board of Scientific Advisors"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18836] "Document type: a report from a Program Review Group to the NCI Director"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18837] "Official process of peer review for federal grants"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18838] "Document type"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18839] "Any record of a medical imaging event whether physical or electronic."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18840] "Use of Giemsa stain to produce a characteristic staining pattern on chromosomes"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18841] "Using acridine orange, this technique produces a chromosomal staining pattern which is the reverse of G-banding."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18842] "Maintenance of vertebrate tissue after removal from the body, by placing in a vessel with a sterile nutritive medium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18843] "Propagation of vertebrate animal cells in culture."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18844] "Protects researchers from involuntary disclosure of personal identifying information acquired in the course of a research project.  Data cannot be subpoenaed and assures anonymity to study participants.  NCI can issue a certificate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18845] "The operating authorities provided to grantees under certain research grant mechanisms that waive the requirement for NIH prior approval for specific actions i.e., change budget categories amounts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18846] "Costs that are incurred for common or joint expenses at an institution by grant or contract activities which cannot be specifically identified with a particular user.  Expressed as a percentage. (formerly known as indirect costs)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18847] "A card issued by the U.S. Immigration Service verifying that the person has been granted status as a permanent resident of the United States and is eligible to receive a training or career award (Alien Registration Receipt Card I-55)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18848] "Additional support to assist in meeting living costs may be provided by the grantee training institution.  This supplement does not require any additional effort from the trainee.  Federal funds may not be normally used except by special arrangements and authorization.  There are no restrictions on use of private funds."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18849] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18850] "Proposes the submission of budget information that once was included in all competing applications initially now submitted at a time when there is a certainty of an award.  It is anticipated this change will reduce the administrative burden for the applicants, their institutions and the reviewers of the application."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18851] "A description of the kind and extent of supervision, guidance and advice that the mentor intends to contribute to the trainee during the proposed award period."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18852] "Persons not U.S. citizens but owe permanent allegiance to the U.S.  They originate from places under U.S. sovereignity, jurisdiction, or administration, i.e. American Somoa, Swains Island. Official Minority Groups (underrepresented in Biomedical Research)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18853] "As defined by various Divisions within the NCI they include: Epidemiology, Nutrition, Behavioral Medicine, Genetics, Public Health, Anthropology, Tobacco Control Research, Demography, Bioethics, Sociology."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18854] "Individual usually trained for clinical work.  Includes M.D., D.D.S., D.M.D., DVM, D.O., D,C., N.D., Pharm. D, R.N. with Doctorate, (contrast  to an academic degree)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18855] "The National Institues of Health will consider only two amendments to the initial grant application.  Regardless of the number of amendments, the NIH will not accept a revised (amended) application that is submitted later than two years beyond the date the initial application was received."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18856] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18857] "A person who is at least seven years beyond their doctoral award."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18858] "The purpose of the NCI Transition Career Development Award (K22) is to provide \"protected time\" for newly independent investigators to develop and receive support for their initial cancer research programs.  This award is intended to facilitate the transition of investigators from the mentored to the independent stage of their careers in cancer research.  It applies to clinicians who are pursuing basic science careers; clinicians who are pursuing careers in patient-oriented research; and to individuals pursuing careers in the prevention, control and population sciences."                                                                                                                                                                                                                                                                                                                                                                                                 
[18859] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18860] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18861] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18862] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18863] "A measurement of the tumor-producing/cancer cell-producing potency of an agent. The carcinogenicity value is usually expressed as milligrams of agent administered per tumor developed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18864] "Outreach programs for the recruitment of women and members of minority groups as subjects in projects of clinical research. (from NIH Guidelines on the Inclusion of Women and Minorities as Subjects in Clinical Research)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18865] "This includes rural, elderly, low-literacy, blue collar, and poor populations. Minorities per se are not included but often belong to one or more or the included categories."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18866] "A funding category that should include all grants having to do with herpes research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18867] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18868] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18869] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18870] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18871] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18872] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18873] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18874] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18875] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18876] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18877] "The Breast Cancer Progress Review Group will work with NCI staff in conducting an in-depth evaluation of the current state-of-knowledge regarding this area, survey the literature and related fields of science, and recommend to the NCI, through the National Cancer Advisory Board and the Board of Scientific Advisors, how the Institute can optimally respond to and stimulate research opportunities related to breast cancer including the improvement in detection technologies. This exercise will help set the NCI's research agenda in breast cancer by identifying and prioritizing those scientific opportunities that are most likely to expand our knowledge base and that will ultimately reduce the burden of this cancer."                                                                                                                                                                                                                                                      
[18878] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18879] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18880] "Function: Provide a national scientific forum to identify research opportunities and to provide recommendations on research priorities, resource needs, and how best to address them across the range of issues in AIDS-related malignancies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18881] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18882] "Development of scientific information and concepts, and dissemination of knowledge regarding early detection techniques, practices, and strategies to reduce mortality and morbidity from cancer.  The program supports clinical trials and other appropriate research, fosters technological development, and encourages the publication of scientific findings and adoption of early detection practices."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18884] "Mission and Organization: To identify broad scientific opportunities that would enable the National Cancer Institute to develop tests that will allow treatment choice to be based on the fundamental properties of a tumor cell. (from http://deainfo.nci.nih.gov/advisory/pog/directors/dev_diag/devdiagfo.htm)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18885] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18886] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18887] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18888] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18889] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18891] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18892] "A class of proteins that bind DNA but require the presence of specific string of bases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18893] "The serum-induced human c-JUN Gene (JUN family) at 1p32-p31 lacks introns and encodes dimeric JUN Protein DNA-binding transcription factors involved in growth-related transcriptional control.  JUN appears to exhibit three distinct functions: dimerization (by a leucine zipper with c-FOS) to form the enhancer-binding protein AP1, TGA(C/G)TCA DNA-binding, and transcriptional activation (enhanced by phosphorylation).  JUN exhibits structural and functional similarity with yeast transcription factor GCN4; both have a DNA-binding domain on the carboxyl end.  JUN also appears to interact with SMAD3/SMAD4 transcription factor heterodimers.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                  
[18894] "The 4 kb human FOS Gene (FOS family) at 14q24.3 contains three introns and sequence homologous to Finkel-Biskis-Jinkins murine osteosarcoma virus.  FOS encodes a DNA-binding c-FOS phosphoprotein that dimerizes with JUN family members via a bZIP motif to form AP1 transcription factor, important in signal transduction, cell proliferation, and differentiation.  Diverse stimuli increase FOS expression: growth factors, cytokines, polypeptide hormones, neurotransmitters, stress, and cell injury.  FOS regulates osteoclast-macrophage lineage determination and neuronal cell survival.  FOS expression is induced by neuronal activity; elements in the FOS promoter mediate NGF induction.  FOS may transform cells through alterations in DNA methylation and histone deacetylation.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                            
[18895] "A biological science concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals having a vertebral column."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18896] "Homologous recombination can operate at both double-strand breaks and free ends. The homologous chromosome serves as a template for DNA repair during recombination."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18897] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18898] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18899] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18900] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18901] "The medical specialty concerned with the use of electromagnetic or particulate radiation in the treatment of disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18902] "Genes, that when altered or inappropriately expressed, lead to malignant transformation or tumor progression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18903] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18906] "A computer system that provides tutorial instruction in academic subjects at an individual level in a format that allows students to master material at their own pace, i.e., CME courses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18907] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18909] "Credit card-sized memory card that stores software applications and modem capabilities and that can be inserted in palmtop and laptop computers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18910] "A protein which specifically binds to Z DNA"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[18911] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18912] "unstable isotopes of high atomic number (elements of mass number from 82 up) which energetically release from their nuclei a particle consisting of two neutrons and two protons, with a positive charge (2e+) and identical to the helium nucleus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18913] "A subdicipline of epidemiology focusing on determination of causes and incidence of malignancies in children."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[18914] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18915] "An insect cell-infecting virus that is used extensively in expression systems for recombinant proteins that require eucaryotic processing systems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18916] "The measure of circulating viral particles in an HIV infected individual.  Used as a prognostic indicator of disease progression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18917] "Microtubule depolymerization is a cellular process typically, though not solely, involved in cell motility and cell division.  Induction of microtubule depolymerization causes interruption of mitosis and is the mode of action of several antineoplastic agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18918] "Microtubule polymerization is a cellular process typically, though not solely, involved in cell motility and cell division.  Stabilization of microtubule polymerization causes interruption of mitosis and is the mode of action of several antineoplastic agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18919] "Level of oxygen saturation within a tumor. Increase in the oxygenation of a tumor acts as a radiosensitizer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18920] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18921] "An interruption in the periodic biochemical and structural events occurring during proliferation of cells such as in tissue culture; the cycle is divided into periods called: G0, Gap1 (G1), synthesis (S1), Gap2 (G2), and mitosis (M). The period runs from one division to the next."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18922] "Development of the individual cell, as distinguished from phylogeny, which is evolutionary development of the species."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18923] "Measures sister chromatid exchange, usually by autoradiography.  Increased sister chromatid exchange is correlated with exposure to mutagenic or genotoxic stimuli."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18924] "Transfer of a nucleus from one cell to another."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18925] "Expression of different genes in different tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18926] "Alternate splicing which is specific and typical for a given tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18927] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18928] "Expression in an abnormal part of the body"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18929] "The term \"isoenzyme\" or \"isozyme\" refers to variants of the same enzyme which can be separated on special conducting media using electrophoresis. It should apply only to those multiple forms of enzymes arising from genetically determined differences in primary structure and not to those derived by modification of the same primary sequence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18930] "Biological functions, activities, or processes of viral elements that support the viability, propagation, or maintenance of a virus. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18932] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18933] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18934] "Location on a DNA strand where the phosphate backbone is intact but the nitrogenous base has been lost from boths DNA strands."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[18935] "Fluorescent in situ hybridization performed on uncondensed DNA strands.  Due to the extended nature of the target DNA this technique provides greater sensitivity for mapping closely situated markers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[18936] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18937] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18938] "1. The study of initiation or promotion of cancer by substances ingested by eating or drinking. 2. Basic studies on the etiologic effects of dietary macronutrients such as fat, vitamins and proteins; food mutagens and carcinogens formed during cooking; carcinogenic compounds and other substances closely associated with food preparation such as free radicals, fibers, and pyrolysis products; and digestive tract mutagens which form as a result of compound biodegradation, biotransformation, etc. The etiology of cancer resulting from deficiencies in the availability of various micronutrients, vitamins, metals, etc., is also of interest."                                                                                                                                                                                                                                                                                                                                    
[18939] "Various NMR methods that can be used to determine 3D structures of macromolecules."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18940] "A phase of the virus life cycle during which the virus replicates within the host cell, releasing a new generation of viruses when the infected cell lyses. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18941] "Costs that can be identified with a particular project or program. Allowable direct costs may include salaries and fringe benefits of principal investigators and supporting staff, expenditures for project-related equipment and supplies, fees and supporting costs for consultant services, expenses for travel, inpatient and outpatient costs for research subjects, publications and other miscellaneous expenses, contract services, and costs for consortium participants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18942] "A group of enzymes removing the serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. (Enzyme Nomenclature, 1992) EC 3.1.3.16."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18943] "Use of restriction endonucleases to analyze and generate a physical map of genomes or genes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18944] "A method to determine the constellation of sequences being actively transcribed at a given moment.  Cell nuclei are harvested, and then supplied with a pulse of redioactive nucleotides.  Transcription is allowed to proceed to an end, but additional initiations are inhibited.  RNAs are then extracted and separated by gel electrophoresis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18945] "A mutation that leads to death of a fetus or embryo prior to birth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18946] "Fibroblasts used as an in vitro model for cell signaling studies"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18947] "Introduction of naked DNA into cells by various methods."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18948] "Encapsilation of DNA within a lipid bilayer with subsequent introduction into a cell by fusion of the liposome with the cell membrane."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18949] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18950] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18951] "A disease state resulting from virus infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18952] "The application of PCR amplification to the isolation of gene regulatory elements present in the genome, without the use of gene-specific primers.  The selection step is accomplished by sequence-specific DNA binding to a particular protein, followed by immunoprecipitation.  Multiple cycles of immunoprecipitation and amplification are used to enrich for the DNA sequence of interest."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18953] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18954] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18955] "An estimate of the percent of each sex will exits for a minority."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18956] "Not characterized in any other way."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18957] "Study of the effects of nutrition on disease incidence and outbreaks."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18958] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18959] "Tissue that is preserved and embedded in paraffin"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18960] "Control of the rate or manner of the periodic biochemical and structural events occurring during proliferation of cells; the cycle is divided into periods called: G0, Gap1 (G1), synthesis (S1), Gap2 (G2), and mitosis (M). The period runs from one division to the next."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18961] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18963] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18964] "Licensing by a governing group to a physician to practice in a particular field of medicine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18965] "The American College of Radiology Imaging Network (Philadelphia, PA) is an infrastructure for multi-institutional clinical trials of imaging and related disciplines applied to cancer. The group has been in operation since March 1999. It does not have a continuing membership."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[18966] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18967] "The chemistry of living organisms and of the chemical, molecular, and physical changes occurring therein, pertaining the the cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18968] "Delineate the mechanisms of transmission and population spread of infection and their impact on disease progression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[18969] "The study of the similarities and differences between different living organisms of the process by which normal cells are transformed into cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18970] "Mechanisms of DNA repair associated with radiation damage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18971] "The visualization of physiological, cellular or molecular processes in living tissue in real time as they take place in cells, for example, blood flow, oxygen consumption or glucose metabolism. (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18972] "Investigations into the relationship between immune function and cancer.  Immunodeficient individuals are less able to mount an attack on cancerous cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[18973] "Sub-discipline of immunology which investigates the molecular interaction involved in antigen recognition and processing, antibody-antigen interactions, cell-cell interactions, cell death, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[18974] "A go-between in the legislature"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[18975] "The branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance in animals of the class Mammalia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18976] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18977] "\"The branch of pharmacology dealing especially with the action of drugs upon various parts of the nervous system. \""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[18978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18979] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18980] "Cytoplasmic proteins that are activated by phosphorylation in response to a large number of cytokines, growth factors, and hormones.  They dimerize and translocate to the nucleus upon activation, where they bind to regulatory cis-elements of specific target genes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[18981] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18982] "NIC96 is a nuclear pore protein identified in yeast.  GFP stands for green fluorescent protein. GFP-NIC96 was used for cell localization studies in vivo."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[18983] "(meh-TAS-ta-size) To spread from one part of the body to another. When cancer cells metastasize and form secondary tumors, the cells in the metastatic tumor are like those in the original (primary) tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[18984] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18985] "The Branch plans and conducts intramural research aimed at identifying new tools for the early detection of cancers and developing cancer intervention agents. (from Division of Cancer Prevention and Control 1994 Annual Report)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[18986] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18988] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18991] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18993] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18994] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18995] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[18998] "Class of enzymes present in various organs and in many cells; catalyze the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. EC 3.1.3.5. (from MSH99)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[18999] "Its fundamental principle is that any physical system can be decomposed into a collection of simple independent local elements each of which interacts only with its immediate neighbors.  In classical mechanics a complete description of any physical system is supposed to be specified by giving the values of the various fields (e.g., the electric field, the magnetic field, etc.) at each of the relevant spacetime points.\""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19001] "Each COG consists of individual orthologous proteins or orthologous sets of paralogs from at least three lineages. Orthologs typically have the same function, allowing transfer of functional information from one member to an entire COG.  (Groups of related genes which have been maintained through evolution ?) from Science 1997;278:631-7"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19002] "DNA sequencing in which chain termination is caused by incorporation of a dideoxynucleotide into a growing DNA strand."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19004] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19005] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19007] "Unordered sequencing.  Unmapped clones spanning a region of interest are sequenced and then assembled into a continuous sequence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19008] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19009] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19010] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19011] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19012] "The assembly of a complete stretch of DNA sequence from a set of sub-sequences whose order in the longer stretch is unknown.  Requires the use of computerized sequence analyses to determine the correct order of fragments in order to assemble to entire stretch of DNA sequence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19013] "Statistical mechanics explains the macroscopic thermodynamic properties in terms of microscopic properties of chemical systems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19014] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19015] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19016] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19017] "Signal induction is the intercellular or intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (e.g., hormone, neurotransmitter, etc.) is transferred to a receptor molecule through a physical binding interaction that alters the conformational and functional state of the receptor molecule and promotes an alteration in cell function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19018] "A haplotype is the order of gene alleles present on a particular chromosome.  Thus, a recombinant haplotype exists when a particular haplotype does not match those of either parent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19019] "Classical technique for sequencing nucleic acids in which visualization of the bases in the sequence relies on the use of radioactive materials, either radiolabeled nucleic acid strands in the chemical degradation method (Maxam-Gilbert), or radiolabeled nucleotides in the dideoxy-termination method (Sanger)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19020] "Computer systems designs for direct use of the public."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19021] "Individuals who have withdrawn from school."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19022] "Established in October 1994 by NCI, the Breast Cancer Surveillance Consortium is comprised of nine academic and public institutions and private organizations. The consortium's three main objectives are: 1) To better understand breast cancer screening practices in the United States by assessing the accuracy, cost, and quality of screening programs and the relation of these practices to changes in breast cancer mortality and other outcomes, such as survival; 2) To foster collaborative research among Consortium participants that examines issues such as regional and health care system differences in the provision of screening and follow-up evaluations; and 3) To provide a foundation for conducting clinical and basic science research, especially basic research on biological mechanisms, that can improve our understanding of the natural history of breast cancer."                                                                                                
[19023] "An estimate of cumulative risk calculated over a lifetime."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19024] "Mechanisms whereby cells attach together to form tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19025] "Loss of the balance between stimulation and inhibition of new blood vessel growth.  A required early step in cancer growth and metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19026] "A computer program developed through the National Surgical Adjuvant Breast and Bowel project.  Estimates risk of breast cancer based upon current age, age at menarche, age at first live birth, number of first-degree relatives who have had breast cancer, number of breast biopsies, and number of biopsies with atypical hyperplasia.  Results are presented as risk of breast cancer, as a percentage, within the next five years or over a lifetime."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19027] "Age of first menstruation.  A risk factor for breast cancer"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19028] "A risk factor for breast cancer"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19029] "The Tobacco Research Implementation Group was created to establish NCI's tobacco-related cancer research priorities for the next five to seven years.  The first initiative of the group creates a collaborative Transdisciplinary Tobacco Research Centers program.  The second program funds state and community tobacco control intervention research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19030] "A group of of six collaborating laboratories at medical centers located throughout the U.S. working to identify new molecular alterations that may be useful for brain tumor diagnosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19031] "Vasculostatin is the 20 kDa C-terminal domain of the vascular basement protein, Nidogen-1.  It has anti-angiogenic properties and is being investigated for clinical applications. (from http://research.bidmc.harvard.edu/OCR/tvotech.asp?Submit=Title&ID=578 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19032] "Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. This protein belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                              
[19033] "Histone deacetylase 3 is one of three identified histone deacetylases with similarity to the yeast global transcriptional regulator Rpd3p.  Two isoforms are produced by alternative splicing and it appears to be expressed ubiquitously.  HDAC3 can be found in complexes that include HDAC4 and HDAC5, deacetylases with similarity to yeast Hda1 deacetylase.  HDAC3 may regulate transcription through binding the zinc-finger transcription factor YY1, increasing its repression activity.  RELA is a nonhistone substrate of HDAC3.  IKBA-dependent nuclear export of deacetylated RELA replenishes the cytoplasmic pool of NFKB/IKBA complexes for NFKB responses.  (from OMIM 605166 and NCI)"                                                                                                                                                                                                                                                                                            
[19034] "Histone deacetylase 4 is one of three identified histone deacetylases with similarity to the yeast Hda1 histone deacetylase.  It is expressed differentially in brain, heart, and skeletal muscle and is found in complexes with HDAC3 and HDAC5.  HDAC4 possesses deacetylation activity with all four core histones.  HDAC4 interacts with multiple proteins.  HDAC4 does not bind DNA directly, but rather through MEF2C and MEF2D.  Binding of HDAC4 to MEF2C represses MEF2C transcription activity.  (from OMIM 605314 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19035] "Encoded by human SAFB Gene, HET Scaffold Attachment Factor B is a highly charged monomeric 915-amino acid scaffold attachment factor with high S/MAR (Scaffold/Matrix-Associating Region) DNA-binding specificity; scaffold attachment factors A, B, C, and D interact with S/MAR DNA. The protein contains potential phosphorylation, glycosylation, and myristylation sites. Eukaryotic interphase chromatin is organized in thousands of loop domains fixed at their base through genomic S/MAR sequences to a nuclear matrix network of protein and RNA important for chromatin compaction, gene expression, and replication. SAFB is a HSP27 promoter-binding protein that decreases HSP27 transcription as an estrogen receptor corepressor. SAFB also interacts with RNA polymerase II and serine-/arginine-rich RNA processing factors and may help to assemble a 'transcriptosome complex' near active genes. (from OMIM and NCI)"                                                         
[19036] "The XRCC1 gene at 19q13.2 encodes XRCC1, which functions in the repair of single-strand DNA breaks and sister chromatid exchange. With no catalytic activity, XRCC1 is required to interact with polynucleotide kinase (PNK) and poly(ADP-ribose) polymerase, linking DNA polymerase-beta and DNA ligase III (LIG3) with single-strand break repair and short-patch base excision repair, respectively, after treatment with ionizing radiation and alkylating agents. In the initial step of processing damaged DNA ends, XRCC1 stimulates the DNA kinase and DNA phosphatase activities of PNK at damaged DNA termini, thus accelerating the overall repair reaction in mammalian single-strand break repair pathway. XRCC1 is also required for full activity of LIG3 in rejoining of broken DNA strands. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity."                                                                    
[19037] "DNA Repair Genes encode DNA Repair Proteins, involved in enzymatic restoration of DNA structure after chemical, radiation, or spontaneous damage. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19038] "Human APE1 Gene (AP/EXOA family) at 14q12 encodes APEX Nuclease, a ubiquitous monomeric apurinic/apyrimidinic DNA repair endonuclease (AP/EXOA family) having 3-prime-, 5-prime-exonuclease, DNA 3-prime repair diesterase, and DNA 3-prime-phosphatase activities. The constitutive gene contains five exons spanning 2.64 kb; the first exon is untranslated.  The 0.5 kb upstream DNA contains only a possible CCAAT box and no other regulatory sites or a TATA box.  A potent activator of p53 protein, APE1 may protect against cell lethality and suppress mutations produced by spontaneous hydrolysis, by chemicals and radiation, or by DNA glycosylases that remove abnormal bases from DNA; abasic sites that can block DNA replication and cause mutations must be corrected to restore genetic integrity. A repressor of the PTH gene, APE binds to promoter negative Ca(2+)-response elements, which are also present in the APE1 gene. (NCI)"                                       
[19039] "Histone deacetylase 5 is one of three identified histone deacetylases with similarity to the yeast Hda1 histone deacetylase.  It is expressed differentially, is found in complexes with HDAC4 and HDAC3, and possesses deacetylation activity with all four core histones.  MEF2A transcription factors interact with HDAC4 and HDAC5, resulting in repression of MEF2-dependent genes.  Muscle differentiation requires release of MEF2 from repression by HDACs.  HDAC5 shuttles from nucleus to cytoplasm when myoblasts are triggered to differentiate.  CAMK1 signaling prevents formation of MEF2/HDAC complexes and induces nuclear export of HDAC4 and HDAC5 by phosphorylation."                                                                                                                                                                                                                                                                                                          
[19040] "HDAC6 functions as a tubulin deacetylase. HDAC6 is localized exclusively in the cytoplasm, where it associates with microtubules and localizes with the microtubule motor complex. In vivo the overexpression of HDAC6 led to a global deacetylation of alpha-tubulin, whereas a decrease in HDAC6 increased alpha-tubulin acetylation. In vitro, purified HDAC6 potently deacetylated alpha-tubulin in assembled microtubules. Furthermore, overexpression of HDAC6 promoted chemotactic cell movement, supporting the idea that HDAC6-mediated deacetylation regulates microtubule-dependent cell motility. Hubbert et al. (2002) concluded that HDAC6 is the tubulin deacetylase, and provided evidence that reversible acetylation regulates important biologic processes beyond histone metabolism and gene transcription. (from OMIM)"                                                                                                                                                        
[19041] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19042] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19043] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19044] "The observable response of a person."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19045] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19046] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19047] "The changes that occur in the population of tumor cells during the course of the disease"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19048] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19049] "The consideration of exogenous factors as variables in disease incident, transmission, and control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19050] "Use of in vitro tissues or organ explants as surrogates for whole organism testing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19051] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19052] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19053] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19054] "The consideration of naturally occurring body factors as a variable in disease incident, transmission, and control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19055] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19056] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19057] "Any place at which medical services are rendered.  It includes traditional locations such as hospitals, clinics, and nursing homes as well as less traditional sites such as schools, supermarkets, and worksites."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19058] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19059] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19060] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19061] "Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures for cancer. (from MSH2000)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19062] "mortality due to cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19063] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19064] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19065] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19066] "COX-1 is known to be present in most tissues as the housekeeper enzyme, maintains normal gastric mucosa and influences kidney function, while COX-2 is inducible by inflammation. They share 60% homology. The expression of Cox-1 is induced by cytokines and mitogens, hence it is likely to play a role in inflammatory diseases such as rheumatoid arthritis. It contains one EGF-like domain.  Both isoforms have the same affinity to convert arachidonic acid to prostaglandin. COX-1. Both forms of COX proteins are membrane associated heme proteins containing cyclooxigenase and peroxidase activities. These enzymes are targets of NSAID (Non steroidal anti-inflammatory drugs) such as aspirin."                                                                                                                                                                                                                                                                                    
[19067] "Dietary Practices refers to a person's choices in food consumption."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19068] "AIDS Malignancy Consortium (AMC) was established in 1995 to carry out Phase I and II studies of innovative therapies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19069] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19070] "The American College of Surgeons is a scientific and educational association of surgeons with the main goal to improve the quality of care for the surgical patient by setting high standards for surgical education and practice."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19071] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19072] "A formal group of people with one or more shared goals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19073] "The American College of Surgeons Oncology Group (ACOSOG) is a cooperative group sponsored by the NCI whose primary goal is to evaluate surgical therapies in the management of patients with malignant solid tumors. The ACOSOG (Durham, NC) includes general and specialty surgeons, representatives of related oncologic disciplines and allied health professionals in academic medical centers and community practices throughout the US and foreign countries. The group is composed of the Administrative Coordinating Center and the Statistics and Data Coordinating. Both groups are based at the Duke Clinical Research Institute."                                                                                                                                                                                                                                                                                                                                                       
[19074] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19075] "The Bypass Budget, which is specified in the National Cancer Act, describes the NCI's priorities and planning and guides NCI efforts in discharging its responsibilities as mandated. Important area of the Bypass Budget include: Extraordinary Opportunities for Investment, Challenge Programs, and Emphasis Areas. (from NCAB Meeting Minutes, Feb. 1999 and Director's Message, 2001 Budget: http://2001.cancer.gov/framedirector.htm)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19076] "The Cancer Center Support Grant (P30) is an NCI grant to help fund designated centers' infrastructure of administration and core facilities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19077] "A geographic area displaying a higher-than-expected rate of cancer incidence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19078] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19079] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19080] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19081] "Ten major, non-profit managed care organizations that are members of the HMO Research Network will participate in the project, known as the Cancer Research Network. A key goal of the Cancer Research Network project is identifying the patient, treatment and delivery system factors that may make a difference in health outcomes for cancer. By combining the data capacities of these large integrated health systems, researchers will be able to study health care patterns among millions of patients who mirror the diversity of the nation in terms of age, gender, income, education, cultural background and location."                                                                                                                                                                                                                                                                                                                                                               
[19082] "Includes NCI information about cancer treatment, screening, prevention, and supportive care.  Can be accessed by telephone with information returned by FAX."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19083] "CANCERLIT is an NCI bibliographic database of more than 1.4 million records of cancer literature published in the past 30 years. It is updated monthly to provide a comprehensive up-to-date resource of published cancer research results."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19084] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19085] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19086] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19087] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19088] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19089] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19090] "The NCI-designated Comprehensive Cancer Centers were established to be national leaders in cancer treatment, research, and education."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19091] "The Comprehensive Minority Biomedical Program (CMBP) represents an effort by the NCI to broaden participation in cancer-related research and training activities by minorities, individuals with disabilities, and individuals seeking to reenter an active research career after taking time off to attend to family responsibilities. The CMBP also seeks to enhance the effectiveness of programs in cancer treatment and cancer control in reaching the minority community and other historically underserved segments of the general population."                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19092] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19093] "The Continuing Umbrella of Research Experience for Underrepresented Minorities Program (CURE) is a new strategy being implemented by the National Cancer Institute to expose minorities to cancer research at the high school and undergraduate levels. The program is being initiated nationwide."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19094] "Cooking Practices refers to methods of preparing foods and their role in health and disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19095] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19096] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19097] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19098] "U01:Research Project (Cooperative Agreements).  U10:Cooperative Clinical Research (Cooperative Agreements).  U13:Conference (Cooperative Agreement).  U26:Organ Systems Coordinating Center (Cooperative Agreements). (Grant Guidelines and Descriptions, NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19099] "A mechanism for collaboration between government and outside scientists that legally defines intellectual property rights and financial and other responsibilities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19100] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19101] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19102] "The aims of the European Organisation for Research and Treatment of Cancer (EORTC) are to conduct, develop, coordinate, and stimulate laboratory and clinical research in Europe to improve the management of cancer and related problems by increasing survival but also patients' quality of life. There are more than 60 institutions and departments that have been recognized by EORTC as affiliated. These groups conduct, on a voluntary basis, laboratory research and/or clinical trials on all types of cancers using a multidisciplinary approach. EORTC maintains close working relationship with NCI and the British Cancer Research United Kingdom in London."                                                                                                                                                                                                                                                                                                                        
[19103] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19104] "the state of a person's genome at a given time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19105] "A hotspot is a center of high activity within a larger area of low activity. The term is applied to different things in different areas of study. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19106] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19107] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19108] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19109] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19110] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19111] "A program to develop and refine experimental models that reflect the etiology and progression of human cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19112] "The National Action Plan on Breast Cancer (NAPBC) is a public-private partnership created to eliminate the epidemic of breast cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19113] "Since its inception in 1957, the NHIS has been a continuing nationwide sample survey in which data are collected through personal interviews with household members by U.S. Bureau of the Census interviewers. Data are used to provide national estimates on the incidence of acute conditions, the prevalence of chronic conditions and impairments, the extent of disability, the utilization of health care services (physician visits and hospital episodes), and other health-related topics. All conditions are coded according to the International Classification of Diseases. The survey is periodically redesigned to emphasize data collection on current health issues. (Alcohol Epidemiologic Data Directory, June 2000)"                                                                                                                                                                                                                                                             
[19114] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19115] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19116] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19117] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19118] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19119] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19120] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19121] "The National Wilms Tumor Study Group (NWTS) was established in 1969 with goals: to improve the survival of children with Wilms tumor and other renal tumors, to study the long-term outcome of children treated successfully by identifying adverse effects of treatment, to study the epidemiology and biology of Wilms tumor and to make information regarding successful treatment strategies for Wilms tumor available to physicians around the world. In 2001 NWTSG was merged into the Children's Oncology Group. Patient entry into NWTSG clinical trial protocols was completed in 2002."                                                                                                                                                                                                                                                                                                                                                                                                   
[19122] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19123] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19124] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19125] "The Center for Scientific Review (CSR) provides staff support to the Office of the Director, NIH, in the formulation of grant application review policies and procedures. In addition, CSR provides central receipt of all PHS applications for research and review."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19126] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19127] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19128] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19129] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19130] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19131] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19132] "Molecular profiling studies utilize measurement of global mRNA and protein patterns towards identification of the individual genes and collections of genes that mediate particular aspects of cellular physiology and pathology. (from CGAP Molecular Profiling Initiative: What is Molecular Profiling? (see http://cgap-mf.nih.gov/)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19133] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19134] "The Office for Protection from Research Risks (OPRR) is organizationally located in the Office of the Director, NIH.  OPRR is charged with interpreting and overseeing implementation of the regulations regarding the Protection of Human Subjects codified at Title 45, Part 46, of the Code of Federal Regulations.  Also, OPRR is responsible for providing guidance on ethical issues in biomedical and behavioral research.  (http://helix.nih.gov:8001/ohsr/whatoprr.php3)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19135] "The Office of Cancer Survivorship was established in 1996 to provide support and a focus for research and other activities dealing with cancer survivors. OCS workshops were held in 1996 and 1997 to define priorities for research, which included the prevalence of physical effects from cancer treatment, the prevalence of second cancers in survivors, quality of life, and quality and cost of follow-up care for survivors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19136] "This network, a cooperative agreement among the Children's Cancer Group, the Pediatric Oncology Group, and the Blue Cross Blue Shield System Association (BCBS) nationwide, will ensure that children of BCBS subscribers receive care at designated centers of cancer care excellence and may promote the enrollment of children in Cooperative Group clinical trials."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19137] "The Pediatric Oncology Group (POG) is a National Cancer Institute-sponsored clinical trials cooperative group of individuals and institutions dedicated to controlling cancer among children and adolescents. (http://www.pog.ufl.edu/)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19138] "The ability of a molecule such as an antibody to bind multiple related target molecules.  A polyvalent vaccine has the ability to elicit protection against multiple, closely related pathogens."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19139] "The Radiation Therapy Oncology Group (RTOG) is a multi-institutional cooperative organization, a national cancer study research group comprised of 250 of the major research institutions nationally and in Canada, funded by NCI, headquartered in Philadelphia with almost 30 years of experience in running clinical trials. More than 40 clinical trials that involve radiation therapy either alone or in conjunction with surgery and/or chemotherapeutic drugs are active at any one time within RTOG. The group is interested in quality of life issues and their effects on the cancer patient"                                                                                                                                                                                                                                                                                                                                                                                            
[19140] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19141] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19142] "The purpose of the Surveillance Implementation Group is to identify what cancer surveillance research is most needed and how best to advance our knowledge of cancer based on the opportunities available.  The SIG was charged with providing advice and recommendations for expanding and enhancing NCI's Cancer Surveillance Research Program."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19143] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19144] "Proteins or protein fragments secreted from, or shed by, tumor cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19145] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19146] "Grants designated with a K prefix and awarded to researchers who have a doctorate to develop their careers as independent scientists.  Length of award can be from three and up to five years.  Some are mentored the entire period whereas others are mentored partially or entirely unmentored."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19147] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19148] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19149] "Underrepresented Minority; any minority group presently underrepresented in biomedical and behavioral research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19150] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19151] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19152] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19153] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19154] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19155] "The consideration of societal factors as variables in disease incident, transmission, and control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19156] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19157] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19158] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19159] "Human DRD2 Gene at 11q23 encodes Dopamine Receptor D2, a G-protein coupled receptor that inhibits adenylyl cyclase activity. Missense mutation in DRD2 causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing results in two different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. Different alleles are associated with increased incidence of substance abuse. The A1 allele has been associated with alcoholism. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                              
[19160] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19161] "The Drosophila NURF complex catalyzes nucleosome sliding.  The Nurf301 subunit contains a bromodomain transcription factor domain, a zinc finger binding domain, nuclear localization signals, and motifs associated with rapid protein degradation.  The HMGA/HMGI(Y)-like domain of Nurf301 facilitates nucleosome sliding.  Nurf301 also interacts with sequence-specific transcription factors, providing a basis for targeted recruitment of the NURF complex to specific genes.  (from OMIM 601819, SWISS-PROT Q24572, O77460, Q24368, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19162] "RSC is an abundant fifteen-protein chromatin remodeling complex containing SNF12 [RSC6p subunit homologue], RSC1 (or RSC2 or RSC4), RSC58 [58 kD subunit], and SFH1.  (from SGD and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19163] "Nuclear SWI2/SNF2 (SNF2/RAD54 Helicase Family) is a 1703-aa, 194-kD general RNA polymerase II transcription regulator component of the SWI/SNF nucleosome/chromatin remodeling complex involved in global transcriptional activation of induced gene expression and coordinate regulation of phospholipid synthesis. This complex alters chromatin structure to facilitate binding of gene-specific transcription factors. Containing a bromodomain domain and three AT Hook DNA-binding repeats, SWI2/SNF2 exhibits strong similarity to Drosophila brahma. (from Swiss-Prot, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                            
[19164] "One of two transcriptional adaptor/HAT (histone acetyltransferase) complexes, SAGA includes SPT8, ADA2, NGG1, SPT20 (or SPT3 or SPT7), SGF29 [29 kD subunit], SGF73 [73 kD subunit].  (from SGD and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19165] "The Drosophila gene Chrac-14 encodes a component of the chromatin accessibility complex.  It contains a histone-fold/TFIID-TAF/NF-Y domain. Similar sequences have been identified in Schizosaccharomyces pombe.  The Drosophila gene Chrac-16 also encodes a component of the chromatin accessibility complex.  (from FlyBase 0043002, 0043001, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19166] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19167] "A component of the SWI/SNF global transcription activator complex, SWI1 acts in complex with Snf2p, Snf5p, Snf6p, and Swi3p to assist gene-specific activators through nucleosome/chromatin remodeling. SWI1 is involved in the regulation of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2.  The SWI/SNF complex is required for induced expression of many genes and alters chromatin structure to facilitate binding of gene-specific dedicated transcription factors.  A zinc finger non-specific RNA polymerase II transcription factor, SWI1 contains an ARID domain.  (from SWISS-PROT P09547, SGD S0005937, and NCI)"                                                                                                                                                                                                                                                                                                                                                           
[19168] "Nuclear Swi3p is an 825-aa, 93-kD general RNA polymerase II transcription factor component of the SWI/SNF nucleosome/chromatin remodeling complex involved in global transcriptional activation of induced gene expression. This complex alters chromatin structure to facilitate binding of gene-specific transcription factors. Swi3p contains a MYB-like domain and interacts with the N-terminus of SNF2. (from Swiss-Prot, SGD, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19169] "A component of the SWI/SNF global transcription activator complex, SNF6 assists gene-specific activators through nucleosome/chromatin remodeling.  The SWI/SNF complex is required for induced expression of many genes and alters chromatin structure to facilitate binding of gene-specific dedicated transcription factors.  SNF6 is a non-specific RNA polymerase II transcription factor.  (from SWISS-PROT P18888, SGD S0001017, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19170] "Human DRD2 Gene at 11q23 encodes Dopamine Receptor D2, a G-protein coupled receptor that inhibits adenylyl cyclase activity. Missense mutation in DRD2 causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing results in two different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. Different alleles are associated with increased incidence of substance abuse. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19171] "Any relative who is two meioses away from a particular individual in a family; a relative with whom one quarter of an individual's genes is shared (i.e., grandparent, grandchild, uncle, aunt, nephew, niece, half-sibling) (from Genetics Home Reference glossary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19172] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19173] "Liposomes that are coated with antibodies for delivery to specific targets."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19174] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19175] "A method to detect apoptosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19176] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19177] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19178] "Cellular Retinoic Acid-Binding Proteins are assumed to play an important role in retinoic acid-mediated differentiation and proliferation processes.  Cytoplasmic CRABP-I and CRABP-II may regulate access of retinoic acid to nuclear retinoic acid receptors.  CRABP-II may participate in a regulatory feedback mechanism to control the action of retinoic acid on cell differentiation.  CRABP-I and CRABP-II belong to the FABP/P2/CRBP/CRABP family of transporters.  (from OMIM 180230, 180231, SWISS-PROT P29762, P29373, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19179] "A molecular biology technique that utilizes a large set of defined cDNA clones attached in a specific grid arrangement to a solid support for nucleic acid hybridization assays in gene mapping studies or in determining gene sequences, sequence variations, or gene expression patterns."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19180] "This effect refers to the high cellular levels of lactic acid in tumor cells, and is named after Otto Warburg who worked on photosynthesis.  Tumor cells use excessive glucose in their rapid growth, and lactic acid is a product of the glycolytic pathway.  This process is not inhibited by oxygen, therefore, it is also called aerobic glycolysis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19181] "A phenotype whereby a subset of tumors are characterized by the simultaneous hypermethylation of multiple promoter-associated CpG islands."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19182] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19183] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19184] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19185] "A method for rapidly obtaining near-pure aggregates of epithelial cell populations.  Smears are prepared, rapidly fixed in methanol and stained.  Microscopic examination permits precise identification of epithelial cell aggregates for separation by laser capture microdissection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19186] "A method to produce defined small DNA fragments from PCR products for analysis of DNA variations by mass spectrometry. (from 7th SPORE Investigators' Workshop)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19187] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19188] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19189] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19190] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19191] "A technique used in developmental biology to investigate the effects of one tissue upon another in induction of differentiation and tissue and organ formation.  Basically, a piece of tissue is transplanted from its normal location to a new location.  This helps to distinguish between intrinsic and extrinsic influences in organ formation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19192] "Nuclear extracts contain proteins in nuclear compartment of the cell and are used to monitor transcription factor activation in a variety of standard protocols, including electrophoresis mibility shift assay (EMSA), DNA footprinting, Western blotting and preparative purification of nuclear proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19193] "Observation chambers, implanted in various animal species and in man, used for intravital microscopy of the microcirculation in granulation tissue, preformed tissue, or of the microvascularization of tissue implants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19194] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19195] "An SDS-PAGE based technique used to identify matrix metalloproteinases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19196] "Cytosolic phospholipase A2 is involved in cell cycle progression via regulation of arachidonic acid metabolism. (Cell Mol Life Sci 2002;59:181-8)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19197] "hSWI/SNF is an ATP-dependent chromatin-remodeling complex implicated in the regulation of gene expression, cell cycle control, and oncogenesis. The complex facilitates transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Subunits of the complex include: BAF57, BAF60a,-b,-c, BAF155, BAF170, BRG-1, BRM, and hSNF5/INI1. BAF57 contains an HMG domain adjacent to a kinesin-like region and binds DNA. BAF155 and BAF170 are BRG-1-associated proteins with dimerization motifs for transcription factors. BRM and BRG-1 are ATPase subunits of the complex and co-activators for nuclear hormone receptors. BRG-1 interacts with BRCA1, a nuclear phosphoprotein transcription and recombination accessory factor."                                                                                                                                                                                                                   
[19198] "A subunit of the hSWI/SNF complex and homolog of yeast SWI3. BAF155 contains a predicted leucine zipper region (dimerization motif for many transcription factors) and a myb-like tryptophan-repeat domain. (from OMIM 601732 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19199] "A subunit of the hSWI/SNF complex and homolog of yeast SWI3. BAF170 contains a predicted leucine zipper region (dimerization motif for many transcription factors) and a myb-like tryptophan-repeat domain. (from OMIM 601734 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19200] "A subunit of the hSWI/SNF complex that contains an HMG domain and a kinesin-like region. BAF57 has DNA-binding characteristics similar to other HMG proteins. (from OMIM 603111 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19201] "A 73 kD subunit of the SWI/SNF global transcription activator complex, SWP73 assists gene-specific activators through nucleosome/chromatin remodeling.  The SWI/SNF complex is required for induced expression of many genes and alters chromatin structure to facilitate binding of gene-specific dedicated transcription factors.  SWP73 is a non-specific RNA polymerase II transcription factor and homologue of Rsc6p subunit of the RSC chromatin remodeling complex with similarity to yeast ycr52w.  (from SGD S0005306 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19202] "A subunit of the hSWI/SNF complex and homologous to yeast SWP73. (from OMIM 601735 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19203] "A subunit of the hSWI/SNF complex and homologous to yeast SWP73. (from OMIM 601736 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19204] "A subunit of the hSWI/SNF complex and homolog of yeast SWP73. (from OMIM 601737 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19205] "An SNF2/RAD54 helicase family member. Containing 1 bromodomain, BRG-1 is a co-activator for nuclear hormone receptors. (from SWISS-PROT P51532 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19206] "An ATPase subunit of the SWI/SNF enzyme, BRM belongs to the SNF2/RAD54 helicase family, contains a bromodomain, and is a co-activator for nuclear hormone receptors.  BRM is a yeast transcription factor SWI2 homologue. Nuclear BRM is phosphorylated, excluded from condensed chromosomes, and strongly reduced during mitosis; phosphorylation does not disrupt the association with SNF5, but correlates with decreased affinity for the nuclear structure in early M-phase.  SWI/SNF enzymes promote MyoD-mediated muscle differentiation by altering chromatin structure in promoter regions of differentiation-specific loci.  (from SWISS-PROT P51531, OMIM 600014, and NCI)"                                                                                                                                                                                                                                                                                                              
[19207] "SWP82, around 82 KD, is one of the subunits of SWI/SNF complex from S. cerevisiae."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19208] "A component of the SWI/SNF global transcription activator complex and the RSC chromatin remodeling complex, SWP61 assists gene-specific activators through nucleosome/chromatin remodeling.  The SWI/SNF complex is required for induced expression of many genes and alters chromatin structure to facilitate binding of gene-specific dedicated transcription factors.  Actin-related SWP61 is a non-specific DNA-binding RNA polymerase II transcription factor.  (from SGD S0006238 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19209] "A component of the SWI/SNF global transcription activator complex and the RSC chromatin remodeling complex, SWP59 assists gene-specific activators through nucleosome/chromatin remodeling.  The SWI/SNF complex is required for induced expression of many genes and alters chromatin structure to facilitate binding of gene-specific dedicated transcription factors.  Actin-related SWP59 is a non-specific DNA-binding RNA polymerase II transcription factor ATPase.  (from SGD S0004636 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19210] "Interacts with SNF5. Not required for DNA-dependent ATPase activity of SWI complex (10). Also part of TFIID and TFIIF complexes (10). Related to MLL translocation partners AF-9 and ENL."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19211] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19212] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19213] "SWI2/SNF2 family proteins possess ATP-dependent chromatin remodeling activity that influences gene expression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19214] "A subunit of unknown function in the fifteen-protein RSC nucleosome/chromatin remodeling complex, Rsc8/Swh3 is a homolog of the SWI/SNF protein SWI3. Swi3/BAF155 contains a leucine zipper motif typical of many transcription factors. Swh3p undergoes dimerization via the coiled-coil C-terminus, forms a complex with RSC6p, interacts with the SWI2/SNF2 ATPase Sth1p, and appears to mediate multiple RSC interactions. SWI/SNF and RSC share conserved components. SWI/SNF proteins display helicase and ATPase activities and appear to regulate gene transcription by altering local chromatin structure. RSC complex is required for transcriptional regulation and nucleosome positioning. RSC maintains a repressive chromatin structure at certain inducible promoters. (from SGD; NAR 26:3739, 1998; EMBO J. 18:2836, 1999; and NCI)"                                                                                                                                                
[19215] "A DNA helicase component of the abundant RSC chromatin remodeling complex, Sth1p has a bromodomain and belongs to the SNF2/RAD54 helicase family.  Sth1p is essential for mitotic growth and meiosis and is involved in G2 phase control.  (from SWISS-PROT P32597, SGD S0001388, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19216] "The Drosophila gene Snf5-related 1 (Snr1) encodes a non-specific RNA polymerase II transcription factor.  It interacts genetically with brm, trx, and osa.  Similar sequences have been identified in Caenorhabditis elegans, Homo sapiens, Saccharomyces cerevisiae, and Tetraodon fluviatilis. (from FlyBase 0011715 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19217] "This protein is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19218] "This protein is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. This protein is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. It is similar in sequence to the Drosophila ISWI chromatin remodeling protein."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19219] "SNF11is involved in transcriptional activation as a component of the SWI/SNF global transcription activator complex, required for the induced expression of a large number of genes by altering chromatin structure to facilitate binding of gene-specific transcription factors.  (from SWISS-PROT P38956 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19220] "Sfh1 is a subunit (of unknown molecular function) of the abundant RSC complex, a fifteen-protein nucleosome/chromatin remodeling complex related to the SWI/SNF complex.  Involved in chromatin modeling and cell cycle progression, Sfh1 is an Snf5p homologue with similarity to Sec14p.  (from SGD S0004313 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19221] "Rsc6 is a subunit (of unknown molecular function) of the abundant RSC complex, a fifteen-protein nucleosome/chromatin remodeling complex related to the SWI/SNF complex.  (from SGD S0000648 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19222] "The Drosophila gene osa encodes a putative DNA binding protein that contains an AT-rich interaction domain (ARID).  It interacts genetically with Antp, ro, brm, Pc, Scr, and several other genes.  Similar sequences have been identified in Caenorhabditis elegans, Homo sapiens, Mus musculus, and Saccharomyces cerevisiae.  (from FlyBase 0003013 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19223] "The Drosophila gene moira (mor) encodes a non-specific RNA polymerase II transcription factor involved in chromatin modeling, which is a component of the nucleosome remodeling complex.  It contains a MYB DNA binding domain and interacts genetically with Antp, Pc, Dfd, Scr, ph-p, and other genes.  Similar sequences have been identified in Homo sapiens, Mus musculus, Saccharomyces cerevisiae, and Schizosaccharomyces pombe.  (from FlyBase 0002783 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19224] "Mediator of Activation is a component of the RNA polymerase II holoenzyme and mediator subcomplex.  (from SGD S0001100 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19225] "The Drosophila gene brahma (brm) encodes a non-specific RNA polymerase II transcription co-activator, assisting one or more transcriptional activators of ANT-C and BX-C homeotic genes.  Brm can counteract the repressive effect of polycomb protein and exhibits DNA-dependent ATPase activity.  It contains a SNF2 related domain, a DEAD/DEAH box helicase, a helicase C-terminal domain, and belongs to the SNF2/RAD54 helicase family.  Two isoforms (long and short) may be produced by alternative splicing.  Highest expression is seen in unfertilized eggs and early embryos.  It interacts genetically with Antp, trx, Psc, Pc, hh, and several other genes.  Similar sequences have been identified in Caenorhabditis elegans, Gallus gallus, Homo sapiens, Mus musculus, and Saccharomyces cerevisiae.  (from SWISS-PROT P25439, FlyBase 0000212, and NCI)"                                                                                                                          
[19226] "PRC1 (Polycomb repressive complex 1) contains the products of the PcG genes Polycomb, Posterior sex combs, polyhomeotic, Sex combs on midleg, and several other proteins.  Preincubation of PRC1 with nucleosomal arrays blocks the ability of these arrays to be remodeled by SWI/SNF.  PRC1 and SWI/SNF are likely compete with each other for the nucleosomal template."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19227] "The Drosophila gene Polycomb (Pc) encodes a transcriptional repressor required for the segment-specific repression of homeotic selector genes by promoting locus-specific chromatin compaction.  Pc may be involved in the stable transmission of a determined state by its effects on chromatin structure.  It contains one chromo domain and interacts genetically with ph-p, Antp, E(Pc), Pcl, Asx, and many other genes.  Similar sequences have been identified in African clawed frog, Caenorhabditis elegans, Homo sapiens, and Mus musculus.  (from SWISS-PROT P26017, FlyBase 0003042, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                           
[19228] "The Drosophila 'Polycomb' group (PcG) proteins form a large multimeric, chromatin-associated complex, repress gene expression, and are part of a system responsible for stable inheritance of gene activity. Polyhomeotic may interact with proteins bound to promoter complexes and negatively regulate homeotic and segmentation genes, and regulate the expression of other pair-rule genes such as EVE, FTZ, and H. The Drosophila PcG protein, polyhomeotic (Ph), contains a SAM domain and shares several motifs with mouse Rae28 protein.  Rae28, Mel18, M33, and Bmi1 are components of a mouse multimeric protein complex. Human HPH1, HPH2, and BMI1 also appear to be part of a multimeric protein complex. HPH2 interacts with BMI1.  Rae28/Mph1, HPH1, HPH2, and Ph share homology in the zinc finger domain and in homology domains I and II.  Homology domains I and II may mediate the heterodimerization interactions of HPH1 and HPH2. (from OMIM, SWISS-PROT and NCI)"           
[19229] "The Drosophila gene Posterior Sex Combs (Psc) encodes a ring-type zinc finger DNA binding protein (Polycomb group) involved in negative regulation of expression patterns of the antennapedia and bithorax homeotic selector gene complexes, and hence maintenance of segmental determination.  Similar sequences have been identified in Homo sapiens and Mus musculus.  Psc interacts genetically with z, brm, Sce, mxc, Asx, and several other genes.  Mutations in Psc generate malformations of the longitudinal tracts.  (from SWISS-PROT P35820, FlyBase 0005624, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                  
[19230] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19231] "A chromatin-remodeling complex that contains the BRG1, BAF170, BAF155, and INI1 homologs of yeast SWI/SNF subunits, as well as a unique subunit, BAF57. E-RC1 appears to be critical for chromatin remodeling and Beta-Globin transcription by EKLF."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19232] "The SMARCC1 Gene at 3p23-p21 encodes BAF155, which is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19233] "The SMARCC2 Gene at 12q13-q14 encodes BAF170, which is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Two transcript variants encoding different isoforms have been found for this gene. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                      
[19234] "Human BAF57 Gene encodes a ubiquitous protein, BAF57, a BRG1-associated subunit of the transcription-promoting hSWI/SNF chromatin-remodeling complex.  The SWI/SNF complex in S. cerevisiae and Drosophila appears to facilitate transcriptional activation of some genes by antagonizing chromatin-mediated transcriptional repression.  Functionally related to SWI/SNF, the mammalian BAF complex consists of nine to twelve subunits, some homologous to SWI/SNF subunits. The mechanism by which mammalian SWI/SNF-like complexes interact with chromatin may involve recognition of higher-order chromatin structure by two or more DNA-binding domains.  BAF57 and the BAF complex appear to bind DNA as it enters or exits the nucleosome.  ATP-dependent nucleosome disruption by the complex enhances transcription factor binding. (from OMIM and NCI)"                                                                                                                                  
[19235] "Human BAF60a Gene (SWI/SNF family) at 12q13-q14 encodes BAF60a, a subunit of the transcription-promoting SWI/SNF chromatin-remodeling complex and homologue of yeast SWP73. BAF60a is similar to BAF60b and BAF60c.  Chromatin remodeling of some genes appears to precede transcriptional activation.  In yeast, the multisubunit SWI/SNF complex is thought responsible for chromatin remodeling.  Human SWI/SNF is composed of nine to twelve BAF polypeptides. (from OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19236] "Human BAF60b Gene (SWI/SNF family) at 17q23-q24 encodes BAF60b, a polypeptide subunit of the transcription-promoting SWI/SNF chromatin-remodeling complex and homologue of yeast SWP73.  BAF60b is similar to BAF60a and BAF60c.  Chromatin remodeling of some genes appears to precede transcriptional activation.  In yeast, the multisubunit SWI/SNF complex is thought responsible for chromatin remodeling.  Human SWI/SNF is composed of nine to twelve BAF polypeptides. (from OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19237] "The SMARCD3 Gene at 7q35-q36 encodes BAF60C, a polypeptide subunit of the transcription-promoting SWI/SNF chromatin-remodeling complex and homologue of yeast SWP73. BAF60C is similar to BAF60A and BAF60B. Chromatin remodeling of some genes appears to precede transcriptional activation. In yeast, the multisubunit SWI/SNF complex is thought responsible for chromatin remodeling. Human SWI/SNF is composed of nine to twelve BAF polypeptides. (From OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19238] "The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                            
[19239] "The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19240] "SWI/SNF-Related Genes encode SWI2/SNF2 family proteins, which possess ATP-dependent chromatin remodeling activity that influences gene expression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19241] "The ERCC6 gene (SNF2/RAD54 Family) at chromosome 10q11 encodes Excision Repair Protein ERCC-6 (ERCC6), a putative DNA or RNA unwinding helicase involved in transcription-coupled excision repair. This protein specifically interacts with CSA proteins and with p44, a subunit of the RNA Polymerase II basal transcription factor TFIIH. It has DNA-dependent ATP-stimulated ATPase activity that may have a role in the displacement of stalled RNA Polymerase II from sites of DNA lesion and in recruitment of a DNA repair component. ERCC6 inhibits fragility of RNU1, RNU2, and RN5S genes. p53 interacts with ERCC6 and activation of p53 inhibits ERCC6, stalling transcription complexes and blocking local chromatin condensation. Defects in ERCC6 are the cause of Cockayne's syndrome type B (CSB). (NCI)"                                                                                                                                                                          
[19242] "Human HLTF Gene (SNF2/SWI2 family) at 3q25.1-q26.1 expresses 4.5 and 5.5 kb mRNAs that encode a 114-120 kD Helicase-Like Transcription Factor, which interacts with Box B regulatory sequences and contains seven consecutive motifs characteristic of ATPases and DNA helicases.  A shorter HLTF variant arises from an alternate translation initiation site.  Yeast SNF2/SWI2, and homologues, optimize gene-specific transcription by dissociating nucleosomes to facilitate DNA binding of regulatory proteins.  HLTF binds to viral promoters/enhancers, displaying enhancer stimulated DNA-dependent ATPase activity; HLTF may affect transcription as a DNA-binding site-specific ATPase.  HLTF contains a RING finger motif apart from an N-terminal DNA-binding domain.  (from OMIM and NCI)"                                                                                                                                                                                             
[19243] "The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein."                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19244] "The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19245] "Important in eukaryotic gene regulation, histone acetylation and deacetylation are catalyzed by histone deacetylase complexes that include SAP30, SAP18, histone deacetylases, histone-binding proteins and other proteins. SAP18 interacts with SIN3 and enhances SIN3-mediated transcriptional repression. Gene-specific targeting of the SIN3 co-repressor complex by DNA-bound repressors is important in eukaryotic gene silencing. The SIN3 co-repressor specifically associates with some transcriptional repressors, including members of the MAD family important in development. The PAH2 domain of SIN3A interacts with the transrepression domain (SID) of MAD1. MAD-MAX complexes repress transcription through recruitment of SIN3 co-repressor. The MXI1 protein family functions as potent antagonists of MYC oncoproteins. They compete with MYC for the protein MAX and for consensus DNA binding sites and to recruit SIN3 proteins and their associated co-repressors. (NCI)"   
[19246] "ARA(70), encoded by proto-oncogene NCOA4, is a ligand-dependent co-activator protein that enhances specific AR transcriptional activity.  The androgen receptor is a transcription factor of the steroid receptor superfamily.  Although several steroid-class receptors recognize the same DNA regulatory sequence, gene-specific activation may be achieved by selective accessory factors that interact with the receptors to determine specificity of target gene activation.  (from OMIM 601984 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19247] "TIP60 interacts with the activation domain of Tat, an activator of HIV gene expression.  The yeast SAS2 transcriptional silencing protein, important for exit from the cell cycle, is closely related to TIP60.  The widely expressed cell surface amyloid-beta precursor protein is cleaved by gamma-secretase and its cytoplasmic tail forms a multimeric complex with the nuclear adaptor protein FE65 and the histone acetyltransferase TIP60.  This complex potently stimulates transcription.  (from OMIM 601409 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19248] "Involved in cell growth, development, and homeostasis, 292-kb human NCOA2 Gene at 8q13.2 encodes 1464-aa 159-kD transcriptional coactivator TIF2, containing N-terminal bHLH and PAS dimerization domains. Present in a complex with NCOA3, IKKA/B, IKBKG, and CREBBP histone acetyltransferase, TIF2 interacts with HIF1A, APEX, NR3C1, and perhaps NR3C2. TIF2 coactivator interacts with steroid receptor superfamily hormone binding domains in a hormone-dependent manner. Recruitment of CBP/p300 and PCAF coactivators for myogenic MYOD and MEF2 expression depends on NCOA1, NCOA2, and NCOA3. NCOA2 is also required for expression of MYOG and CDKN1A, and for myogenic differentiation. The NCOA2 bHLH/PAS and C-terminal activation domains mediate coactivation of MEF2C through its MADS box. The NCOA2 N- and C-termini interact with MYOG. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                            
[19249] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19250] "The human thyroid hormone receptor-associated protein (TRAP)-Mediator complex was originally identified as a large multimeric complex that copurifies with the thyroid hormone receptor (TR) from HeLa cells and markedly enhances TR-mediated transcription in vitro. More recent studies have implicated TRAP-Mediator as a coactivator for a broad range of nuclear hormone receptors as well as other classes of transcriptional activators. TRAP-Mediator may play an important coregulatory role in androgen receptor-mediated gene expression. (from J Biol Chem. 2002;277:42852-8)"                                                                                                                                                                                                                                                                                                                                                                                                         
[19251] "SMRT is a receptor-interacting factor for retinoid and thyroid-hormone receptors. The repressor function of thyroid hormone and retinoic acid receptors involves direct interaction with SMRT, possibly by stabilizing/promoting interaction with transcription factor TFIIB. Ligand causes SMRT dissociation from the receptor, triggering activation. Binding of ligand to nuclear hormone receptors induces a conformation that attracts co-activator proteins containing a NR box. NCOR1 has a similar NR box, CoRNR box, that is required for nuclear hormone receptor interaction. Sequences flanking the corner box determine nuclear hormone receptor specificity. Hormone action and differential recognition of unliganded and liganded nuclear hormone receptors by co-activators and co-repressors appears to be due to subtle differences between CoRNR and NR boxes. (from OMIM 600848 and NCI)"                                                                                      
[19252] "In acute myeloid leukemia, the frequent t(8;21)(q22;q22) translocation produces a chimeric AML1/ETO gene.  Association of the AML1/ETO product with the NCOR/HDAC complex blocks hematopoietic differentiation.  The interaction requires ETO coiled-coil regions and is responsible for abnormal recruitment of NCOR, transcriptional repression, and impaired differentiation of primary hematopoietic precursors. AML1/ETO transcripts are present in a fraction of stem cells, monocytes, marrow B-cells, and in colony-forming cells of erythroid, granulocyte-macrophage, and/or megakaryocyte lineages, but not in T-cells.  (from OMIM 133435 and NCI)"                                                                                                                                                                                                                                                                                                                                     
[19253] "MAD and MXI1 bZIP proteins belong to a subfamily of MAX-interacting proteins.  MAX interacts with MYC via bZIP interaction domains and MAX binding is essential for MYC activity; MYC homodimers are inactive.  MAD/MAX and MXI1/MAX heterodimers form a DNA-binding complex similar to MYC/MAX. MAD and MXI1 act as transcriptional repressors and appear to antagonize MYC by competing for MAX, and for DNA binding sites, and recruit SIN3 proteins and their associated co-repressors.  (from OMIM 600021, 600020, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19254] "Containing a bromodomain, Gcn5p is a general transcriptional activator operating in concert with other DNA-binding transcriptional activators, such as GCN4 or HAP2/3/4.  Gcn5p functions in the SAGA adaptor/HAT complex as a nucleosomal histone acetyltransferase to promote transcriptional activation.  HAT Gcn5p also functions as a heterodimer with ada2 as part of the ADA adaptor/HAT complex that consists of hfi1/ada1, ada2, ada3, spt20/ada5 and gcn5.  It has a strong preference for Lysine 14 of H3 and a lower preference for Lysines 8, 16 of H4.  (from SWISS-PROT Q03330, SGD S0003484, LocusLink 2648, and NCI)"                                                                                                                                                                                                                                                                                                                                                              
[19255] "Gene which encodes the dopamine D2 receptor (DRD2 receptor).  Different alleles are associated with increased incidence of substance abuse."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19256] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19257] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19258] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19259] "A single, or type-equivalent repetitive, enzyme-dependent chemical transformation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19261] "Protein dimerization is the process by which two protein molecules of similar, or dissimilar, chemical composition bind to one another by covalent or non-covalent interaction(s) to form a new functional product."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19262] "The metabolism of proteins and amino acids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19263] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19264] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19265] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19266] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19267] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19268] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19269] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19270] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19272] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19273] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19274] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19276] "Human SAFB Gene at 19p13.3-p13.2 encodes HET Scaffold Attachment Factor B, a highly charged monomeric 915-amino acid protein with high S/MAR DNA-binding specificity. A 3.4 kb transcript is widely seen. The protein contains putative phosphorylation, glycosylation, and myristylation sites. Eukaryotic interphase chromatin is organized in loop domains fixed through genomic S/MAR sequences to a nuclear matrix network of protein and RNA important for chromatin compaction, gene expression, and replication. SAFA, -B, -C, and -D interact with S/MAR DNA. SAFB is also an HSP27 promoter-binding protein that decreases HSP27 transcription as an estrogen receptor corepressor. SAFB interacts with RNA polymerase II and serine-/arginine-rich RNA processing factors and may help to assemble a 'transcriptosome complex' near active genes. (from OMIM 602895 and NCI)"                                                                                                            
[19277] "The proto-oncogene SRC at 20q12-q13 encodes a tyrosine kinase that regulates cell communication in the control of embryonic development and cellular growth. SRC binds beta-arrestin-1 after stimulation of beta-2 adrenergic receptors. This interaction targets the complex to clathrin-coated pits and activates the MAP kinases ERK1 and ERK2. TRANCE and its receptor RANK are critical regulators of dendritic cell and osteoclast function. TRANCE activates the anti-apoptotic serine/threonine kinase AKT1 through a signaling complex involving SRC and TRAF6. SRC and TRAF6 interact with each other and with RANK upon receptor engagement. TRAF6 enhances SRC kinase activity leading to tyrosine phosphorylation of downstream targets such as CBL. SRC kinase activity is down regulated by phosphorylation of a critical C-terminal tyrosine (tyr530) and a truncating mutation in SRC at codon 531 is activating, transforming, tumorigenic, and metastasis-promoting."            
[19278] "A chimeric SIL/SCL locus, produced by interstitial deletion between SIL and the 5-prime untranslated region of SCL and disrupting the SCL regulatory region, has been observed.  SCL mRNA expression becomes regulated by the SIL promoter, leading to inappropriate SCL expression.  This type of rearrangement is frequently seen in T-cell acute lymphoblastic leukemia.  (from OMIM 181590 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19279] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19280] "A high-affinity thyroid hormone receptor expressed in many tissues, with highest levels in the central nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19281] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19282] "A new technology involving high-throughput molecular analysis/screening of clinical tissue specimens.  Tissue microarrays spatially arrange 500-1000 tumor biopsies or other tissue onto a microarray block, which is then sliced into sections for probing DNA, RNA or protein targets to provide coincident analysis of all specimens in the array.  Subsequent sections can be analyzed with additional probes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19283] "An NCI scientist whose role is to identify sources of human tissue specimens and help researchers locate the tissue and related data they need. (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19284] "The person who is responsible for a specific research project or environment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19285] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19286] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19287] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19288] "Encoded by Apoptosis Regulation Genes, Apoptosis Regulator proteins either promote or impede the initiation, progress, or rate of apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19289] "Human Fibroblast Growth Factor Receptor 1 Gene (FGFR family) at 8p11.2-p11.1 encodes a 130 kD type I transmembrane protein that contains three extracellular C2-type Ig-like domains, an unusual acidic region, and an intracellular tyrosine kinase domain.  Many FGFR1 forms are produced by alternative splicing.  Ig-like domains 2 and 3 appear to bind ligand.  FGFA stimulates FGFR1 tyrosine kinase activity.  FGFR1, the human equivalent of chicken basic FGF receptor, also binds basic FGF.  An FGFR1 variant with partial kinase domain binds to FGFA without autophosphorylation or activation of PLC; it may regulate cellular responses to acidic FGF.  Defects in FGFR1 cause Pfeiffer Syndrome.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                
[19290] "Fibroblast Growth Factor Receptor Family Genes encode Fibroblast Growth Factor Receptor Family proteins, cell surface receptors that react with (basic or acidic) fibroblast growth factors and frequently possess tyrosine kinase activity to elicit specific cellular responses to these growth factors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19291] "The 4.5 kb human Fibroblast Growth Factor Receptor 2 Gene (FGFR family) at 10q26 encodes a type I membrane protein tyrosine kinase receptor for paracrine acidic and basic FGF.  FGFR2 is closely related to mouse Bek and more distantly to chicken bFGFR.  FGF receptors have three extracellular C2-type Ig-like domains, a transmembrane segment, and a cytoplasmic tyrosine kinase domain.  Ig-like domains 2 and 3 appear to bind ligand; D2 and the D2/D3 linker region define a general binding site, alternatively spliced D3 provides specificity.  Isoforms KGFR and BEK, with different expression patterns in murine embryogenesis, vary only in a short D3 sequence that generates distinct ligand-binding features.  The dimeric FGFR2 ectodomain binds to two FGF1 ligands and a central heparin decasaccharide simultaneously.  FGFR2 defects cause Crouzon Syndrome, Jackson-Weiss Syndrome, Apert Syndrome, or Pfeiffer Syndrome.  (from SWISS-PROT, OMIM, and NCI)"             
[19292] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19293] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19294] "HMGN1 enhances the transcriptional potential of chromatin when incorporated into nucleosomes during, but not after, chromatin assembly on replicating DNA. Two molecules of HMGN1 can bind to nucleosome cores, independently of the underlying DNA sequence, in a cooperative fashion to limit nucleosome mobility and stabilize the structure of the nucleosome core without stabilizing the higher order chromatin structure. By modifying the structure of nucleosomes, the proteins affect the local structure of the chromatin fiber leading to an increase in the rate of transcriptional elongation but not initiation. (Semin Cell Biol 1995 Aug;6(4):247-55)"                                                                                                                                                                                                                                                                                                                             
[19295] "In MALDI-TOF, a laser pulse is fired into a protein or peptide sample contained in a light-absorbing matrix. A small explosion vaporizes and ionizes the sample. In the presence of a high electric field, peptide ions are accelerated down an evacuated flight tube. Because large particles travel more slowly than small ones, the masses of the ionized particles are determined by measuring their arrival time at the end of the tube"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19296] "RAEB: Any medical substance or procedure not generally accepted by orthodox western medicine or an unorthodox application of an otherwise accepted substance or procedure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19297] "RAEB: Medical substance or procedure in the process of becoming accepted by orthodox western medicine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19298] "RAEB: Health Research affecting Inuit/Eskimo populations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19299] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19300] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19301] "Studies of the mechanisms by which maternal exposure to carcinogens cause cancer in in children."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19302] "Exposure to potentially harmful chemical, physical, or biological agents in utero or pre-conception and its potential link with disease induction."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19303] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19304] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19305] "The PTC1 chimeric oncogene (RET/PTC1) is generated by fusion of the RET proto-oncogene receptor tyrosine kinase domain to the 5-prime terminal region of the H4 gene containing a putative leucine zipper.  H4 shows no significant homology to known genes and the protein function is unknown.  The RET receptor ligand is Glial Cell Line-Derived Neurotrophic Factor.  The putative H4 leucine zipper mediates dimerization of the PTC1 oncoprotein, essential for PTC1 transforming activity.  (from OMIM 601985 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19306] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19307] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19308] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19309] "Angiotropin is a potent angiogenesis factor isolated from the serum-free media of cultured, lectin-activated peripheral monocytes. (from Arch Surg 1989;124:693-8). Angiotropin is nonmitogenic but promotes angiogenesis by inducing migration of endothelial cells. (from Pharmacol Ther 1991;51:195-216)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19310] "Any subcellular or molecular event, process, or condition involved in translocation of a biological macromolecule across a cell membrane from one site or compartment to another. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19311] "A MYC family member, MAX is a bHLH/ZIP transcription factor that forms a heterodimer with MYC and binds to a specific DNA site in the MYC gene and DDX18, a DEAD box family member.  The level of MAX is not modulated with respect to cell proliferation or differentiation, unlike most immediate early gene products.  MAX also interacts with MIX2.  (OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19312] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19313] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19314] "RET oncoproteins result from mutation of the RET proto-oncogene, which encodes a receptor for Glial Cell Line-Derived Neurotrophic Factor.  Mutations in the RET proto-oncogene are associated with MEN2A and Hirschsprung disease.  Some oncogenic point mutations cause constitutive activation of the kinase function of RET, which in turn results in autophosphorylation of RET tyrosine residues critical for signaling.  Other point mutations effect additional aspects of RET protein biology.  Some RET oncogenic mutations involve chimeric rearrangements.  The PTC1 oncogene is generated by fusion of the RET receptor tyrosine kinase domain to the H4 leucine zipper that mediates transforming dimerization of the oncoprotein.  Two other RET rearrangements are PTC6 and PTC7.  In PTC6, RET is fused to the N-terminal part of Transcriptional Intermediary Factor-1-alpha and in PTC7 RET is fused to a C-terminal part of TIF1-gamma.  (from OMIM 164761 and NCI)"            
[19315] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19316] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19317] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19318] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19319] "Network of medical centers that will evaluate promising treatments for children with brain malignancies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19320] "Similar to Phased Innovation Award, created to support the pilot application of instrumentation, techniques and analytic tools relevant to research on the molecular biology of cancer. (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19321] "To foster multidisciplinary research on cellular and molecular imaging, NCI has established In Vivo Cellular and Molecular Imaging Centers.These centers will narrow the gap between the discovery of new cancer genes and intracellular pathways, and the translation of these discoveries into clinically useful, minimally invasive imaging approaches to expanding our understanding of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19322] "Mechanism to fund single project applications in patient oriented or basic research near the payline and for which reviewer criticisms can be addressed quickly.  (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19323] "NCI meetings on state-of-the-art or emerging technologies (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19324] "Organization that hosts cancer-related listservs. (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19325] "Epidemiologic research on the environmental and genetic determinants of cancer. (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19326] "Also called molecular profile. Molecular fingerprint is the unique pattern of gene expressions or responses that were generated by treament of anticancer drugs in cancer cells by cDNA microarray technique."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19327] "Determining which genes are active and inactive and the level of specific proteins that are present in a particular tumor. (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19328] "Proposed mechanism for providing resources for \"mechanisms\" researchers to provide evidence that a proposed new cancer relevant molecule is a good target for drug discovery. (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19329] "The AXIN1 Gene at 16p13.3 encodes Axin, an ubiquitous protein that inhibits dorsal axis formation by interfering with the WNT pathway and is involved in degradation of beta-catenin. WNT signaling causes translocation of Axin to the membrane and interaction with the intracellular domain of the WNT signal-transducing co-receptor LRP5. This destabilizes Axin and stabilizes cytoplasmic beta-catenin accumulation, which then binds to TCF/LEF1 transcription factor and up regulates target gene expression. Axin interacts with GSK3B and with beta-catenin and may facilitate phosphorylation of beta-catenin and APC by GSK3B. Axin may also bind to gamma-catenin, APC, DVL and PP2A. It is phosphorylated by GSK3B and dephosphorylated by PP2A. Axin interaction with beta-catenin is mediated by the armadillo repeats of beta-catenin. Axin contains a regulator of G protein signaling domain and a DIX domain. (from SWISS-PROT, OMIM , and NCI)"                               
[19330] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19331] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19332] "All cell types, depending on their functions, have unique, identifiable \"signatures\" - special characteristics such as which genes are active and what proteins or other cellular products are manufactured by the cell.  During transformation of a normal cell to a cancer cell, the signature changes, and that change becomes a signal of the presence of cancer.  (Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19333] "Promises to speed the translation of ideas developed in the laboratory to early stage clinical trials by simplifying the grant application process and providing a rapid turnaround from application to funding."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19334] "A branch of chemistry dealing with the biosnthesis of the compounds."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19335] "Groups of scientists who link their expertise and resources in collaborative efforts to address important questions about human cancer.  Examples include: Cancer Genetics Network and Diagnostic Imaging Network."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19336] "Mechanism to facilitate partnerships between NCI-Designated Comprehensive Cancer Centers and research institutions to provide patients and populations with improved access to studies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19337] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19338] "NCI initiative to develop and maintain partnerships between scientific researchers and community leaders from a broad range of minority and underserved populations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19339] "A science professional who pursues structural analysis of living material at every level of organization by all methods."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19340] "Centers coordinate multidisciplinary approaches to research questions, provide access to the most advanced research technologies and take rapid advantage of new research opportunities.  (SPORES - Specialized Programs of Research Excellence are an example focused on specific disease).  Additional examples include tobacco research, molecular and in-vivo imaging, communications, populations health and interventions directed against molecular targets."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19341] "Proposed network in collaboration with National Institute on Drug Abuse (NIDA) to study tobacco use initiation and prevention, treatment and treatment of tobacco related cancers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19342] "To spur development of daring technologic improvements in cancer treatment and detection in the 21st century.  A five-year, $48 million program which seeks to stimulate development of radically new technologies in cancer care that can transform what is now impossible into the realm of the possible for detecting, diagnosing, and intervening in cancer at its earliest stages of development. The vision of the Unconventional Innovations Program is to couple detection and diagnostic technologies based on remote sensing to far less invasive treatments than those employed today which, though often effective, can be uncomfortable and painful. The ultimate goal of the program is to provide medical care for cancer patients that detects early cellular changes typical of cancer and includes treatments that target molecular alterations from occurring in an individual patient's cells."                                                                                 
[19343] "Multidisciplinary and translational research teams focused on a specific disease, modality, biologic process or scientific area of particular significance. They are awarded sizeable amounts of flexible funding to enable them to rapidly address emerging scientific opportunities or specific challenges."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19344] "The Common Data Elements (CDE) Dictionary contains a repository of detailed information pertaining to each standard element used to collect essential data related to cancer care.These elements were identified by the National Cancer Institute (NCI) in collaborative effort with partners who represent a variety of clinical and basic science disciplines, and defined using standards described by recognized authorities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19345] "Proposed NCI supported network to provide research community with means to evaluate and validate signatures and possible diagnostic value."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19346] "A subcellular biological function, activity, or process that involves, depends on, or is supported by physical forces (e.g., electrostatic charge) of attraction or repulsion between at least two molecular or subcellular entities. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19347] "The worsening of a cancer over time. This concept is most often used for incurable cancers where the stage of the cancer is an important determinant of therapy and prognosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19348] "A biologic function, activity, or process involving either specialized organ functions, individual organs, organ systems, body parts, or whole organisms. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19349] "Processes that involve and promote the transfer or transmission of stimulatory (sensory) information from the periphery to more central organized structures and mechanisms involved in processing information. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19350] "This framework will serve as a tool to create an interface among the basic, translational, clinical, and population-based research communities that participate in the research discovery process. Employing this knowledge management system will unify these research communities and will reduce drastically the time and effort needed to create and use existing or new information, making research discoveries possible at a scientist's desk, in addition to the lab. By speeding the discovery process and translation of the best discoveries into clinical interventions, the CII will transform cancer care through more effective and efficient information exchanges among all involved in cancer research. Finally, this knowledge management system will create new synergies within and among the fields of research, resulting in a dramatic acceleration of our progress against cancer. (From Bypass Budget 2001)"                                                              
[19351] "The Clinical Trials Information Management System is an effort to develop an integrated system for managing various aspects of a clinical trial.  The overall goal of the project is to create an integrated tool to support all aspects of a clinical trial, including Protocol development/submission, Administration, Patient Management, and Data Collections and Acquisitions. (from http://www.upci.upmc.edu/internet/benedum/clinicalTrials/)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19352] "A system to standardize and streamline data reporting and reduce administration needs.  This system achieves rapid, accurate, and secure capture of clinical trial data with minimal effort. Successfully captures the majority of trial data within hours of submission. (Bypass Budget 2001 & 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19353] "The c-SKI proto-oncogene encodes a transcriptional repressor that homo- and heterodimerizes with the related protein, snoN.  SMAD3 associates with nuclear SKI protein in response to TGFB1 signaling, repressing transcriptional activation by SMAD3, and rendering cells resistant to the growth-inhibitory effects of TGFB.  The effects of SKI can be overcome by increased expression of SMAD3.  (from OMIM 164780 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19354] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19355] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19356] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19357] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19358] "Fully active, able to carry on all pre-disease performance without restriction. (Eastern Cooperative Oncology Group)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19359] "Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work (Eastern Cooperative Oncology Group)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19360] "Dead. (Eastern Cooperative Oncology Group)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19361] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19362] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19363] "Stipends or grants-in-aid granted by foundations or institutions to individuals for study."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19364] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19365] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19366] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19367] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19368] "The purpose of the NCI Transition Career Development Award (K22) is to provide \"protected time\" for newly independent investigators to develop and receive support for their initial cancer research programs.  This award is intended to facilitate the transition of investigators from the mentored to the independent stage of their careers in cancer research.  It applies to clinicians who are pursuing basic science careers; clinicians who are pursuing careers in patient-oriented research; and to individuals pursuing careers in the prevention, control and population sciences."                                                                                                                                                                                                                                                                                                                                                                                                 
[19369] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19370] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19371] "National Research Service Awards (NRSA) are made to individual fellowship applicants selected for award as a result of national competition for research training in specified health-related areas.  The National Institutes of Health (NIH) awards NRSA individual postdoctoral fellowships (F32) to the most promising applicants to support full-time research training related to the mission of the NIH awarding components. Some specialized individual predoctoral fellowships (F31s and F30s) and Senior  Fellowships (F33s) are also provided under the NRSA. (NRSA Guide: Sections I and II)"                                                                                                                                                                                                                                                                                                                                                                                            
[19372] "The objective of this Exploratory/Developmental Grant (R21) mechanism is to encourage applications for one-time grants to support: 1) innovative research directions requiring preliminary testing or development; 2) exploration of the use of approaches and concepts new to a particular substantive area; 3) research and development of new technologies, techniques or methods; or 4) initial research and development of a body of data upon which significant future research may be built, i.e., the data should have a high level of impact on the field. (from http://grants.nih.gov/grants/guide/pa-files/PA-00-073.html)"                                                                                                                                                                                                                                                                                                                                                              
[19373] "The R33 award is to provide a second phase for the support for innovative exploratory and development research activities initiated under the R21 mechanism. (from http://grants.nih.gov/grants/funding/ac.pdf)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19374] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19375] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19376] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19377] "Basic Sciences Research (includes vaccine and chemotherapy development); Research Enhancement; Construction (extramural)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19378] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19379] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19380] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19381] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19382] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19383] "KU70 protein is the 70 kD subunit of the KU autoantigen, a heterodimeric DNA repair complex that binds DNA double-strand breaks, is the DNA-binding component of the DNA-dependent protein kinase, and facilitates repair by nonhomologous end-joining.  KU70 and KU80 form a dyad-symmetrical molecule with a preformed ring that encircles duplex DNA.  KU protein is also involved in V(D)J recombination.  KU is identical to DNA helicase II, an ATP-dependent DNA unwinding enzyme.  (from OMIM 152690 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19384] "Biophotonics; the technology of using light beams and forms of energy to diagnose and monitor medical conditions. (from Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19385] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19386] "Cooking of meats over an open flame.  A cooking practice associated with increased risk of breast cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19387] "Organizing term for the Proteins tree"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19388] "Organizing term for the Proteins tree"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19389] "An important class of serum proteins in which a spherical hydrophobic core of triglycerides or cholesterol esters surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Classified according to density: chylomicrons, large low density particles, very low density, low density and high density species. Important in lipid transport, especially cholesterol transport in the blood stream. Abnormalities in lipoprotein metabolism have been implicated in certain heart diseases. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19390] "Organizing term for the Proteins tree"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19391] "Proteins secreted out of the cell to perform a function in the extracellular medium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19392] "Organizing term for the Proteins tree"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19393] "Protein within the interior of the cell; excludes membrane, mitochondrial, and nuclear proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19394] "The Senior Scientist Award (K05) provides stability of support to outstanding scientists who have demonstrated a sustained, high level of productivity and whose expertise, research accomplishments, and contributions to the field have been and will continue to be critical to the mission of the particular NIH center or institute.  The award provides salary support for award periods of five years as a means of enhancing the individual recipient's skills and dedication to his/her area of research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19395] "Fluorescence bronchoscopy is based on the fact that normal tissue fluoresces differently than abnormal tissue when exposed to an appropriate wavelength of light and that this difference can be detected."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19396] "Transcription factors in the nuclear receptor superfamily for which a natural ligand has not been identified."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19397] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19398] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19399] "The medical specialty that pertains to the anatomy, physiology, pathology, symptomatology, and therapeutics related to the blood and blood-forming tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19400] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19401] "Oversees and coordinates technology transfer and partnering with the federal government to develop leading-edge technologies into products that improve public health."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19402] "PSA circulates in the blood in two forms: free or attached to a protein molecule.  With benign prostate conditions, there is more free PSA, while cancer produces more of the attached form.  A more accurate predictor of cancer than either a patient's age or his total PSA level. (from Cancer Information Service)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19403] "The ratio of serum PSA to transition zone volume.  Takes into account the size of the prostate in determining the significance of an elevated PSA level."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19404] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19405] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19406] "A risk factor for colorectal, stomach, and pancreatic cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19407] "Top level term which includes Biological Markers, Risk Factors, and Prognostic Factors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19408] "High consumption of vegetables and related micronutrients; exerts a moderate protective effect on the risk of developing breast cancer. (from Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19409] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19410] "Pharmacogenomics defines the study of the association between genetics and drug response, as well as the interplay of genotype and drug efficacy. (from Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19411] "The space that is left after the surgical removal of a body part or tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19412] "A nonstructural protein of unknown function.  It localizes to keratin filaments and so may have a role in virus release by disturbing the integrity of the infected cell. (from Virology 1996;218:114-26)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19413] "A viral DNA binding protein involved in viral replication.  It is a transcriptional activator and major regulator of viral DNA replication and gene expression.  May interact with p53 in vivo. (from Oncogene 1999;18:7748-54 )"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19414] "Academic Detailing is an approach to educating physicians in their offices.  Academic detailing uses very short, relatively inexpensive, focused educational mechanism that can be used with physicians in the office.  Ii involves short one-on-one conversation. (from Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19415] "Any of various amplification and detection strategies applied to detection of virus contamination in donor blood.  Specifically designed to detect recently infected individuals during the latency period before seroconversion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19416] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19417] "Created as part of the NCI Strategic Plan to Reduce Health Disparities, the Cancer Intervention and Surveillance Modeling Network is a collaborative group of grantees modeling the population impact of cancer control interventions for breast, prostate, and colorectal cancer. Modeling provides an opportunity to better understand the sources of health disparities in cancer mortality, extrapolate results of randomized clinical trials to groups that carry the heaviest burden of disease and have sometimes been underrepresented in trials, and provides strategies for cancer control interventions to reduce cancer-related health disparities."                                                                                                                                                                                                                                                                                                                                    
[19418] "In humans the H19 gene is expressed exclusively from the maternal chromosome.  Its product is reported to be an untranslated RNA.  The gene is a developmentally regulated gene with putative tumor suppressor activity. H19 expression in developing skeletal and smooth muscles correlates with specific differentiation events in these tissues. Its accumulation increases during skeletal muscle development with maximal accumulation in adulthood and no expression in other tissues. Expression of H19 in skeletal muscle correlates with nonproliferative, actin-positive muscle cells. Loss of H19 expression may be involved in Wilms tumorigenesis. (from OMIM and NCI) )"                                                                                                                                                                                                                                                                                                              
[19419] "The nuclei of precancerous lesions are distinct in that they become enlarged, crowded and hyperchromatic.  Light-scattering spectroscopy can diagnose early epithelial cancers based on the scattering of light through their enlarged nuclei. (from Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19420] "The CDKN1B gene encodes cyclin dependent kinase inhibitor 1B.  CDKN1B expression is regulated by PI3K/PKB and RAS/RAL regulated AFX-like forkhead proteins.  PTEN blocks cell cycle progression in G1 through negative regulation of PI3 kinase/AKT signaling to CDKN1B, increasing CDKN1B, decreasing cyclin D1, and inhibiting AKT phosphorylation.  Involved in G1 arrest, nuclear CDKN1B inhibits cyclin/CDK complexes.  CDKN1B, a CASP-3 apoptotic target, is phosphorylated by CCNE1/CDK2, ubiquitinated by SKP2, and degraded.  Low CDKN1B expression is associated with a poor prognosis.  The human gene is located at 12p13."                                                                                                                                                                                                                                                                                                                                                             
[19421] "The erbB2, erbB3, and erbB4 receptors. These proteins form homo and heterodimers, which complicates the assignment of specificities: it is known that erbB2 homodimer do not bind heregulin, but erbB2/erbB3 heterodimers do."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19422] "Cell partitioning techniques used to determine the subcellular distribution of molecules of interest."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19423] "Technique for making and testing many complex materials in parallel: computer guided synthesis in which all possible combinations are made. Combinatorial synthesis is not random, but systematic and repetitive, using sets of chemical \"building blocks\" to form a diverse set of molecular entities.  Initial synthesis is usually made on a solid substrate. The technique lays down the materials in a checkerboard arrangement, as thin squares arranged in a grid.  Scientists use combinatorial chemistry to create large populations of molecules, or libraries, that can be screened efficiently en masse. (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                   
[19424] "Polymorphism, single-stranded conformational, detection. Altered migration of single-stranded DNA molecules in non-denaturing gels based upon 3-D conformation. Uses PCR and/or restriction enzymes to generate short dsDNA molecules spanning a sequence of interest. The dsDNA molecules are heat denatured, and then quickly cooled. Each ssDNA molecule will assume a secondary structure (conformation) dependent upon its unique sequence.  Base mutations will often result in altered conformations, with altered mobilities, which can be visualized following separation in non-denaturing gels. (NCI/OSP)"                                                                                                                                                                                                                                                                                                                                                                               
[19425] "Thin layer deposition.  Commonly used in integrated circuit fabrication."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19426] "The processing techniques, such as deposition, etching, and patterning, that are utilized to produce miniaturized structures and devices with feature sizes and resolution in the micron domain.  Uses a combination of micromachining and integrated circuit fabrication technology. (from U. Louisville course description)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19427] "Any representation of the individual steps in a metabolic pathway of a cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19428] "A novel karyotyping technique which is based on the simultaneous hybridization of 24 chromosome-specific painting probes labeled with different fluorochromes or fluorochrome combinations. The measurement of defined emission spectra by means of interferometer-based spectral imaging allows for the definitive discernment of all human chromosomes in different colors. (from Schrock et al., Hum Genet 1997:101:255-62)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19429] "Genes and proteins for which the expression or presence of can help predict the course and outcome of a disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19430] "The WRN gene at 8p12-p11.2 is deficient in Werner syndrome, characterized by genetic instability associated with cancer predisposition. The predominantly nucleolar WRN protein contains seven helicase motifs, two of which are found in all ATP-binding proteins. WRN protein catalyzes DNA unwinding and is a 3-prime-to-5-prime exonuclease but the N-terminal exonuclease activity is separate from the helicase activity. WRN may be a suppressor of illegitimate homologous recombination and may control genomic stability. WRN binds the p50 subunit of POLD1 and may facilitate POLD-mediated DNA replication/repair. The N terminus of WRN interacts with KU70 and KU86, which stimulate WRN exonuclease activity."                                                                                                                                                                                                                                                                      
[19431] "Mechanism to fund current awardees whose research is going better than expected or who are poised to test new ideas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19432] "Immunophenotype is the characterization of a set of cells according to the antigens expressed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19433] "The non-catalytic beta subunit of Shiga toxin may be useful as a fusion vector for induction of antigen-specific cytotoxic T lymphocyte responses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19434] "A non-catalytic subunit of Telomerase.  It is the homolog of Tetrahymena p80 telomerase protein.  It is also a component of Vault, a large cytoplasmic ribonucleoprotein of undetermined function.  In addition to TEP1, telomerase also contains an RNA component, TERC, and an enzymatic component, TERT."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19435] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19436] "RNA polymerases comprise a group of enzymes that catalyze extension, one nucleotide at a time, of the 3 prime-end of an RNA strand along a complementary DNA template."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19437] "v-sis Platelet Derived Growth Factor beta polypeptide is the viral homologue of PDGFB.  Viral oncogenes originate from normal cellular genes by recombination between a parent nontransforming virus and host cellular DNA; the cellular genes often code for important functions in cell growth or tissue differentiation.  PDGF is the major serum polypeptide mitogen for cells of mesenchymal origin and has two dissimilar subunits, A and B.  The B chain has homology to SIS and is alone sufficient for mitogenesis.  Most proliferating cells are programmed to undergo apoptosis unless specific survival signals are provided.  PDGF promotes proliferation and inhibits apoptosis by activating the RAS/PIK3/AKT1/IKK/NFKB1 pathway, inducing putative anti-apoptotic genes.  (from OMIM 190040 and NCI)"                                                                                                                                                                               
[19438] "A 36 question survey for measuring health status and outcomes from the patient's point of view. Designed for use in surveys of general and specific populations, health policy evaluations, and clinical practice and research.  Measures 8 health concepts: 1) Limitations in physical activities because of health problems, 2) Limitations in usual role activities because of physical health problems, 3) Bodily pain, 4) General health perceptions, 5) Vitality (energy and fatigue), 6) Limitations in social activities because of physical or emotional problems, 7) Limitations in usual role activities because of emotional problems, 8) Mental health (psychological distress and well-being). (from Medical Outcomes Trust)"                                                                                                                                                                                                                                                         
[19439] "A 12 question subset of the SF-36.  Designed to be administered in a shorter time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19440] "(an-jee-AH-gra-fee) A procedure to x-ray blood vessels. The blood vessels can be seen because of an injection of a dye that shows up in the x-ray pictures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19441] "Emerging technologies refers to new techniques and devices, or older techniques being used in new ways.  These technologies need to be clinical tested to determine whether they would have a positive impact on patient outcome.  Includes all areas of cancer research including detection, diagnosis, treatment, and prevention."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19442] "A consortium of institutions connected by a model Web-based system that both provides direct access to data related to archived specimens and protects patient confidentiality."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19443] "The Office of Communications encompasses the former Office of Cancer Communications, The Office of Liason Activities, and the Office of Cancer Information, Communication and Education.  Its mission is to communicate accurate information about cancer and NCI activities to a wide array of audiences, including: cancer patients, family members, health care providers, community health educators, advocates, Congress, the media, and the general public."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19444] "A funding mechanism designed to ensure that new investigators share the same granting success rate as more established applicants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19445] "Proteomics aims at quantifying the expression levels of the complete protein complement (the proteome) in a cell at any given time. While proteomics research was initially focussed on two-dimensional gel electrophoresis for protein separation and identification, proteomics now refers to any procedure that characterizes the function of large sets of proteins. It is thus often used as a synonym for functional genomics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19446] "The Cancer Clinical Trials Education Program provides training to nurses and social workers to educate patients and their families about clinical trials. (Bypass Budget 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19447] "A web site (http://cancernet.nci.nih.gov/) which hosts NCI's searchable clinical trials database containing information on over 1,800 active clinical trials.  (Bypass Budget 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19448] "A web site (http://cancertrials.nci.nih.gov/) which acts as NCI's online gateway to clinical trials resources. It integrates information about clinical trials participation (including human subjects' protection), treatment advances, and related resources for patients and physicians.  (Bypass Budget 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19449] "A funding mechanism of NCI to provide underrepresented minority health professionals with the opportunity to gain expertise in research.  (Bypass Budget 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19450] "The Cancer Trials Support Unit (CTSU) streamlines and centralizes administrative, financial, and data collection tasks. The submission and development of ideas for protocols are made easier through electronic forms, templates, and databases.  (Bypass Budget 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19451] "The objectives of this survey are to: 1) determine the utilization of genetic tests by physicians at the national level, 2) ascertain physician knowledge of available genetic tests for specific cancer susceptibility genes, 3) examine physicians' general attitudes toward testing, 4) explore possible variation in utilization and knowledge/attitudes by medical specialty, type of practice, year of training completion, board status, urbanization, and geographic region. (http://www-dccps.ims.nci.nih.gov/ARP/Physician/testing.html)"                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19452] "To analyse the entire genome (total genetic complement) of an individual, organism, cell or tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19453] "The first nationally representative survey of the American public - with emphasis on underserved populations - about their access to and use of cancer-related health information. From NCI's 2002 budget"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19454] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19455] "During HIV infection, the virus may evolve and become able to use alternative cell surface factors as receptors for cell attachment and entry.  This can increase the tissue range of infection or allow the virus to overcome drugs which block virus entry."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19456] "Aptamers are double-stranded DNA or single-stranded RNA molecules that bind specific molecular targets."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19457] "The use of 3D CT or MRI scans to construct a simulated visualization of patient specific organs similar or equivalent to those produced by standard endoscopic procedures.  Virtual endoscopic visualization avoids the risks associated with real endoscopy.  Additionally, there are many body regions not accessible to or compatible with real endoscopy that can be explored with virtual endoscopy. (from R. Robb presentation at Visible Human Project Conference)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19458] "A technique for quantitation of cell DNA content."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19459] "The WNT7A gene encodes a human homologue of the MMTV integration site 7A, Drosophila wingless segment polarity gene.  WNT7A guides development of the female reproductive tract and controls limb development at the dorsoventral axis.  Gene expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.  WNT7A is a cysteine-rich extracellular matrix intercellular signaling glycoprotein implicated in the regulation of cell fate and patterning during embryogenesis and with a high transforming potential in mouse, involved in intracellular signaling.  The human gene is located at 3p25."                                                                                                                                                                                                                                                                                                                                                     
[19460] "WNT Family Genes encode secreted structurally related signaling WNT Family Proteins, implicated in oncogenesis and in several developmental processes, including regulation of cell fate and embryonic patterning. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19461] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19462] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19463] "Receptor Genes encode cell surface or cytoplasmic receptor proteins that each bind to specific signaling factors (such as a hormone, antigen, or neurotransmitter) causing a conformational and functional change in the ligand-bound receptor, altering its interaction with target molecules and leading to changes in cellular physiology through modification of the activity of one or more signal transduction pathways."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19464] "An island in the South Atlantic Ocean, south-southwest of the Cape of Good Hope (South Africa). (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19465] "Islands in the southern Indian Ocean, south of Africa, about equidistant between Africa, Antarctica, and Australia. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19466] "Islands in the Indian Ocean, about two-thirds of the way from Madagascar to Antarctica. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19467] "A country in Central Asia, northwest of China. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19468] "Alphanumeric systems designed to represent country names. Three current systems are the ISO 3166 (two letter representation), the UN system (three letter or 3 number representation), and the US State Department system (two letter representation)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19469] "Expressed in multiple somatic tissues (highest in testis, heart, skeletal muscle, pancreas), human TOP3 Gene (TOPI/III Family) encodes long (1001-aa, 112-kD) and short (976-aa) alternative DNA Topoisomerase III Alpha isoforms that share no homology with DNA TOPI. TOP3A catalyzes transient ATP-independent breaking/rejoining of single DNA strands, reducing negative supercoils and controlling DNA topology during transcription. The enzyme forms a complex with BLM (aa 1-133 of BLM), which recruits TOP3A to PML nuclear bodies and regulates somatic sister chromatid recombination. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                    
[19470] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19471] "A group of islands in the South Atlantic Ocean, east of the tip of South America. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19472] "The U.S. Minor Outlying Islands consist of Baker Island, Howland Island, Jarvis Island, Johnston Atoll, Kingman Reef, Midway Island, Navassa Island, Palmyra Atoll, and Wake Atoll. The US State Department considers them separate entities, each with its own country code."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19473] "A country in Northern Africa, bordering the North Atlantic Ocean, between Mauritania and Morocco. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19474] "A staging system for Chronic Lymphocytic Leukemia.  The Binet classification integrates the number of nodal groups involved with the disease with bone marrow failure. Its major benefit derives from the recognition of a predominantly splenic form of the disease, which may have a better prognosis than in the Rai staging, and from recognition that the presence of anemia or thrombocytopenia has a similar prognosis and does not merit a separate stage.  Clinical stage A: no anemia or thrombocytopenia and fewer than three areas of lymphoid involvement (Rai stages 0, I, and II); Clinical stage B: no anemia or thrombocytopenia with three or more areas of lymphoid involvement (Rai stages I and II): Clinical stage C: anemia and/or thrombocytopenia regardless of the number of areas of lymphoid enlargement (Rai stages III and IV) (from OncoLink)"                                                                                                                       
[19475] "A staging system for Chronic Lymphocytic Leukemia.  Stage 0: absolute lymphocytosis (>15,000 per cubic millimeter) without adenopathy, hepatosplenomegaly, anemia, or thrombocytopenia; Stage I: absolute lymphocytosis with lymphadenopathy without hepatosplenomegaly, anemia, or thrombocytopenia; Stage II: absolute lymphocytosis with either hepatomegaly or splenomegaly, with or without lymphadenopathy; Stage III: absolute lymphocytosis and anemia (hemoglobin <11 g/dL) with or without lymphadenopathy, hepatomegaly, or splenomegaly; Stage IV: absolute lymphocytosis and thrombocytopenia (<100,000 per cubic millimeter) with or without lymphadenopathy, hepatomegaly, splenomegaly, or anemia.  (from OncoLink)"                                                                                                                                                                                                                                                                
[19476] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19477] "MRI method that measure the diffusion of water in the tissue, rather than the content of water as measured in conventional MRI."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19478] "The International Prognostic Index (IPI) is a list of five factors that help doctors assess how a non-Hodgkins lymphoma patient might respond to a certain treatment or predict the risk of disease recurrence and survival following therapy.  The factors are: 1) patient's age, 2) stage of disease: an indication of how localized or widespread is the disease, 3) LDH levels: serum levels often correlate with the amount of tumor in the body, 4) the number of extranodal, non-lymphatic sites found, 5) the patient's overall health. (from Lymphoma Research Foundation of America glossary (www.lymphoma.org))"                                                                                                                                                                                                                                                                                                                                                                         
[19479] "A type of PSA assay which compares changes in PSA levels over time. A sharp rise in the PSA level raises the suspicion of cancer. (from Cancer Information Service)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19480] "There is a natural increase in PSA level with increasing age.  Thus, the normal PSA level changes with age.  Age-adjusted PSA establishes normal values in 10-year age blocks.  (from Cancer Information Service)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19481] "Research that focuses on the genetics and mechanisms of cell transformation; the role of oxygen radicals in the carcinogenesis process; and identification and properties of tumor promoters and mechanisms of tumor promotion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19482] "Studies on the toxicology and pharmacology of smoking and tobacco-related exposures.  The research in this category is directed toward understanding the nature of the chemicals involved, and the reaction mechanisms behind, the deleterious effects of tobacco smoke and smokeless tobacco products."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19483] "The CSK gene is ubiquitously expressed and encodes a novel cytoplasmic tyrosine kinase that down regulates the tyrosine kinase activity of c-src oncoprotein through phosphorylation of the c-src carboxy terminus.  Since cell transformation by SRC oncoproteins is caused by mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene.  The SH3 domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells.  This association is highly specific; PEP may be an effector and/or regulator of CSK in T-cells and other hemopoietic cells."                                                                                                                                                                                                                                                                                                                                              
[19484] "Nogo are high molecular weight transmembrane inhibitors of neurite out-growth found in CNS myelin.  Nogo is expressed by oligodendrocytes in white matter of the CNS, but not by Schwann cells in peripheral nerves.  The C-terminal region shares homology with neuroendocrine-specific proteins and other members of the reticulon gene family.  NOGO consists of a putative large extracellular domain with seven predicted N-linked glycosylation sites, two or three transmembrane domains, and a short C-terminal region.  An extracellular domain of NOGO inhibits axonal extension but does not alter non-neuronal cell morphology.  Nogo A, B, and C are encoded as splice varients of a single gene.  (from OMIM 604475 and NCI)"                                                                                                                                                                                                                                                         
[19485] "Tankyrase, a protein containing 24 ankyrin repeats and homology to the catalytic domain of PARP, is localized to human telomeres.  The tankyrase ankyrin domain interacts with TRF1, which regulates telomere length by inhibiting telomerase.  Tankyrase may have PARP activity and may function as acceptor for adenosine diphosphate (ADP)-ribosylation. Tankyrase may act as a positive regulator of telomere elongation by inhibiting TRF1; tankyrase-mediated ADP-ribosylation of TRF1 may open the telomeric complex, allowing access to telomerase.  Tankyrase gene was mapped to 8p23.1. (from OMIM 603303 and NCI)"                                                                                                                                                                                                                                                                                                                                                                       
[19486] "The combination of computational DNA sequence analysis with structural determinations by X-ray crystallography and NMR techniques to study protein structural families. (from RFA: GM-99-009)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19487] "A laboratory test to measure carcinoembryonic antigen (CEA), a substance that is sometimes found in an increased amount in the blood of people who have certain cancers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19488] "Expressed in liver, 100-kb human UGT1A1 Gene (UDPGT Family) contains at least 12 promoters/first exons separately spliced to common downstream exons 2-5 to yield 533-aa 60-kDa (precursor) microsomal UDP-Glucuronosyltransferase 1A1 variants with unique N-termini (and substrate specificity) preceding a common conserved 245-aa C-terminus and involved in detoxification. Catalyzing glycosyl addition from a nucleotide sugar to a hydrophobic molecule, UDPGTs represent a major glucuronidation pathway in conjugation and elimination of toxic lipophilic xeno- and endobiotics to water-soluble compounds. UGT1A1 glucuronidates its preferred substrate bilirubin and acts on simple phenols, flavones, and C18 steroids. UGT1A1 may be a major gene controlling serum bilirubin levels. (NCI)"                                                                                                                                                                                        
[19489] "A liposome that contains a repair protein for use in topical lotion as therapy or prevention."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19490] "Collection of proteins that are evolutionarily related.  This is reflected in the structural and functional similarities as well as in the extent of sequence conservation or residue identity. (from SCOP)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19491] "The National Institute of General Medical Sciences (NIGMS) primarily supports basic biomedical research that is not targeted to specific diseases or disorders."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19492] "Encoded by Protein Phosphatase Genes, Protein Phosphatase enzymes remove tyrosine-, serine-, or threonine-bound phosphate groups from many phosphoproteins, including enzymes phosphorylated by a tyrosine kinase or a serine/threonine kinase. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19493] "An island in the Caribbean Sea, east of Puerto Rico. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19494] "All activities associated with tobacco smoking; concerns factors that influence individuals to start or stop smoking, how these factors differ by age, sex, ethnic group, educational or socioeconomic level, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19495] "Widely expressed human Insulin-Like Growth Factor 1 Receptor Gene (INSR family) at 15q25-q26 encodes IGF1R, a type I membrane protein that contains two fibronectin type III-like domains and has tyrosine protein kinase activity.  p53 suppresses IGF1R promoter activity.  Drosophila InR is homologous to mammalian insulin receptors.  IGF1R enhances cell survival and controls cell cycle progression.  The receptor binds IGF I with high affinity and IGF II with lower affinity.  Like INSR, cleavage of the precursor generates alpha and beta subunits.  IGF1R is a tetramer of two alpha and two beta chains linked by disulfide bonds; alpha chains form the ligand-binding domain while beta chains contain the kinase domain.  The SH2 domain of PIK3R3, a regulatory subunit of PI3 kinase, interacts with IGF1R and INSR in a kinase-dependent manner.  (from SWISS-PROT, OMIM, and NCI)"                                                                                         
[19496] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19497] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19498] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19499] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19500] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19501] "Human Soluble Guanylate Cyclases (Adenylyl Cyclase 4/Guanylyl Cyclase Family) are heterodimeric (alpha/beta) nitric oxide-activated cytoplasmic enzymes that catalyze conversion of GTP to cGMP second messenger. The main receptors for nitric oxide in the cardiovascular system and for nitrovasodilator drugs, alpha/beta interaction is required for guanylyl cyclase activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19502] "1) To direct or use toward the Golgi apparatus as a target.  Targeting of the Golgi apparatus by specific substances to disrupt or alter its function.  2) Related to structural elements in a protein, such as a peptide sequence, that directs the localization of a protein or protein complex to the Golgi apparatus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19503] "A cell division process consisting of a complex series of events or phases (prophase, prometaphase, metaphase, anaphase, telophase) by means of which two daughter nuclei normally receive identical complements of the chromosomes and DNA content characteristic of the original somatic cells of the species.  Part of the process by which the body grows and replaces cells.  Although used interchangeably with cell division, strictly speaking the term mitosis refers to nuclear division; cytokinesis refers to division of the cytoplasm.  In some cells, as in many fungi and the fertilized eggs of many insects, nuclear division occurs within the cell unaccompanied by division of the cytoplasm and formation of daughter cells. (NCI)"                                                                                                                                                                                                                                           
[19504] "DNA Replication Factor (CDT1), encoded by the CDT1 gene, is essential for DNA replication and chromatin licensing. Geminin inhibits inappropriate origin firing by targeting CDT1. CUL4 prevents aberrant reinitiation of DNA replication, at least in part, by facilitating the degradation of CDT1. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19505] "Caspase-2, encoded by the CASP2 gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspase-2 is synthesized as an inactive proenzyme which is activated by an alternative CD 95 pathway which involves the formation of a complex between oligomerized CD 95 and the accessory proteins RIP and RAIDD. After activation, caspase 2 induces apoptosis by triggering the caspase cascade. The proteolytic cleavage of this caspase is induced by a variety of apoptotic stimuli. In contrast to caspase 8, caspase 2 contains no death effector domain. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                            
[19506] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19507] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19508] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19509] "Mechanisms whereby proteins are sorted or directed to their proper location in the cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19510] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19511] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19512] "Telomeres enable cells to distinguish natural chromosome ends from damaged DNA because uncapped telomeres elicit a DNA damage response that halts cell proliferation. The protection of human chromosome ends primarily depends on the telomeric protein TRF2 and telomere capping involves the formation of a higher order structure, the telomeric loop or t-loop. Telomeres consist of a tandem array of telomeric DNA repeats bound to specialized telomeric proteins. Telomerase activity lengthens terminal regions of eukaryotic telomeric DNA by RNA-templated addition of repeated DNA sequences. Active telomerase forms a structure at the telomere that prevents chromosome ends from being sensed as DNA damage. Telomerase is regulated by sequence-specific DNA binding proteins that bind telomeric DNA repeats. Through separate domains, these proteins bind additional proteins to assemble a higher-order complex on the telomeric DNA. (from PMID 11850778 and NCI)"           
[19513] "Sequence-specific posttranscriptional gene silencing.  It is mediated by 21- and 22-nucleotide small interfering RNAs (siRNAs) generated by ribonuclease III cleavage from longer dsRNAs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19514] "The Drosophila gene Acf1 encodes ATP-dependent chromatin assembly factor large subunit, a component of the chromatin assembly complex involved in chromatin assembly/disassembly.  Acf1 contains a PHD-finger and is able to modulate the internucleosomal spacing of chromatin by an ATP-dependent mechanism.  Similar sequences have been identified in Caenorhabditis elegans, Homo sapiens, Mus musculus, and Saccharomyces cerevisiae.  (from FlyBase 0027620 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19515] "Human AREG Gene (EGF family) at 4q13-q21 encodes Amphiregulin, a growth-modulating heparin-binding/heparin-inhibited bifunctional glycoprotein that inhibits growth of some cell types and stimulates proliferation of other cells.  AREG is an autocrine growth factor for keratinocytes, as well as a mitogen for astrocytes, Schwann cells, and fibroblasts.  Amphiregulin contains cysteines in disulfide linkage, an EGF-like domain, and binds to the EGF receptor, but not as well as EGF.  The protein may contain oligosaccharides and/or lipid moieties not obligatory for its biological activity.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                    
[19516] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19517] "Genes from any non-human organism."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19518] "Proteins from organisms other than human."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19519] "Proteins found in Drosophila."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19520] "Formed in Jan, 2001 by the merger of the Division of Clinical Sciences and the Division of Basic Sciences, the Center for Cancer Research is the largest component of the National Cancer Institute's Intramural Research Program."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19522] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19523] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19524] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19526] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19527] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19529] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19531] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19533] "In molecular biology, refers to the transcriptional regulation of a chimeric gene by the prokaryotic repressor/operator system of the tetracycline operon, permitting the production of a specific gene product or protein in a cell culture or a transgenic animal at controlled times.  The chimeric gene contains the regulatory promoter elements of the tetracycline gene, and is transcriptionally regulated by the binding of recombinant tet repressor to these promoter elements in the absence of soluble tetracycline."                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19534] "Human Heregulin Gene (NRG family) at 8p22-p11 encodes Heregulin, a glycoprotein ligand for ERBB3 and ERBB4 receptor tyrosine kinases. Alternative splicing generates a minimum of fourteen isoforms subdivided into two categories: Ig-NRG isoforms, type I (cytoplasmic tail) and II (tailless), contain an Ig-like domain; CRD-NRG isoforms (with or without tail) contain a cysteine-rich domain. All isoforms perform distinct tissue-specific functions related to growth and differentiation. Expressed in many tissues, type I predominates in endocardium. GGF2 (type II) is the major form in skeletal muscle cells. Translated products exist as a membrane protein or a proteolytic soluble factor. Glycosylation precedes cleavage. Membrane-bound forms appear inactive. Ligand binding, mediated by the EGF-like domain, recruits co-receptors ERBB1 and ERBB2. The cytoplasmic domain may interact with the LIMK1 LIM domain. (from SWISS-PROT, OMIM, and NCI)"                      
[19535] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19536] "Tomographic examination of the kidney."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19537] "(in-tra-VEE-nus pye-LAH-gra-fee) IVP. X-ray study of the kidneys, ureters, and bladder. The x-rays are taken after a dye is injected into a blood vessel. The dye is concentrated in the urine, which outlines the kidneys, ureters, and bladder on the x-rays."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19538] "(MAM-o-gram) An x-ray of the breast."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19539] "Toxicogenomics is a new scientific field that elucidates how the entire genome is involved in biological responses of organisms exposed to environmental toxicants/stressors. Toxicogenomics combines information from studies of genomic-scale mRNA profiling (by microarray analysis), cell-wide or tissue-wide protein profiling (proteomics), genetic susceptibility, and computational models to understand the roles of gene-environment interactions in disease. (from National Center for Toxicogenomics homepage)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19540] "Any one of the major conceptual divisions of the eukaryotic cell cycle, based on characteristic cytological and biochemical events, that occur in the order G1 (Gap 1)-S (Synthesis)-G2 (Gap 2)-M (Mitosis) and lead to cell division. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19541] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19542] "A function or process affecting multiple organisms or organism groups. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19543] "Telomerase reverse transcriptase protein, TERT, adds telomeric DNA to the ends of eukaryotic chromosomes. Telomerase contains three subunits: the catalytic subunit TERT, an RNA component TERC, and a non-catalytic protein TEP1. Telomerase preserves chromosome integrity by maintaining telomere length; small amounts of sequence are lost because of incomplete DNA replication. Telomerase adds telomeric repeats to the 3-prime end of a G-rich primer using an RNA template. This enzyme activity is undetectable in most normal cells, but present in immortal cells and cancer tissues. Telomerase activity is an independent prognostic factor in neuroblastoma. MYC, the ubiquitous transcription factor that controls cell proliferation, directly activates transcriptional expression of TERT. (from J Clin Oncol 2000. 18:2582, OMIM 187270 and NCI)"                                                                                                                              
[19544] "A protein or peptide, by its own, without perceptible function before it is assembled into a functional entity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19545] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19546] "Nuclear Factor I.  Identified as a cellular protein involved in Adenovirus DNA replication, and independently as a transcriptional activator (CTF-1, CAAT-binding transcription factor).  Ubiquitously expressed.  Four genes, NFIA, NFIB, NFIC, and NFIX encode NF-I proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19547] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19548] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19549] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19550] "The consideration of chemical factors as a variable in disease incident, transmission, and control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19551] "Mechanisms whereby cells attach to the extracellular matrix."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19552] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19553] "The random change of the occurrence of a particular gene in a population, genetic drift is thought to be one cause of speciation when a group of organisms is separated from its parent population. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19554] "Regulatory Genes encode products that regulate or circumscribe the activity of diverse cellular functions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19555] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19556] "The NCI-designated Cancer Center focuses on basic research or/and cancer control research, but does not have clinical oncology research program. Formerly was called Basic Science Cancer Center."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19557] "In zoology, denoting the sex to which those belong that produce spermatozoa; an individual of that sex."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19558] "Groups of uneducated individuals who cannot read or write."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19559] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19560] "Outcome; a phenomenon that follows and is caused by some previous phenomenon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19561] "The consideration of unspecified lifestyle factors as variables in disease incident, transmission, and control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19562] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19563] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19564] "Any alteration in cell state that promotes or renders a cell or cell population more vulnerable or prone to malignant conversion or transformation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19565] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19566] "The use of dyes and radioactive substances to identify the first lymph node to which cancer is likely to spread from the primary tumor.  Cancer cells may appear first in the sentinel node before spreading to other lymph nodes and other places in the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19567] "Non-homologous DNA end joining (NHEJ) can only repair double-strand breaks in which two DNA ends are rejoined by DNA ligase at regions of little or no homology to avoid degradation by DNA nucleases or noncomplementary overhanging ends. However, the disadvantage is that it can lead to loss of information from the DNA because of resection of the broken ends. NHEJ is operational throughout the cell cycle but may be more important during G1, prior to DNA replication, or in cells that are no longer cycling."                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19568] "The TEP1 gene encodes a protein component of the telomerase ribonucleoprotein complex which catalyzes the addition of new telomeres on the chromosome ends as well as the vault particle which is a large cytoplasmic complex with an undetermined function. TEP1 is an RNA-binding protein that binds both the telomerase RNA and a small RNA within the vault particle. Whereas TEP1 is not essential for telomere length maintenance or telomerase activity, it is important for the stabilization and recruitment of the vault RNA to the vault particle. TEP1 RNA is expressed in variety of tissues tested and TEP1 is conserved from ciliates to humans. The TEP1 gene is located at chromosome 14q11-q12 on the long arm of chromosome 14. (NCI)"                                                                                                                                                                                                                                           
[19569] "A cell adhesion molecule expressed in epithelial cells.  Overexpression in breast cancer may be correlated with histologic grade and a predictor of poor prognosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19570] "The MLH3 gene (MUTL/HEXB family) at chromosome 14q24.3 encodes DNA Mismatch Repair Protein MLH3. MLH3 is ubiquitously expressed in various tissues and two isoforms are produced by alternative splicing. MLH3 interacts with MLH1 and shares the same interacting region on MLH1 with PMS1 and PMS2. The balance of these three competing MLH1 partners may be important in the repair of mismatches in DNA. Malfunction of the mismatch repair system results in a mutator phenotype, which is manifested as microsatellite instability (MSI). MSI is often divided into 2 forms: MSI-high (MSI-H) and MSI-low (MSI-L), based quantitatively on the observed frequency of genomic mutations. An appreciable frequency of somatic MLH3 mutations in MSI-H tumors is consistent with a possible role for this gene in the progression of colorectal cancer tumorigenesis. Germline mutations of this gene may also play a role in hereditary nonpolyposis colorectal cancer (NCI)"                  
[19571] "The MSH3 gene (MutS family) at 5q11-q12 encodes DNA Mismatch Repair Protein MSH3, a mismatch repair (MMR) protein. Mismatch recognition in human cells is mediated by two heterodimers, MutS alpha (MSH2/MSH6) and MutS beta (MSH2/MSH3) with different mispair recognition properties and abilities. Both participate in repair of a dinucleotide insertion-deletion heterology but only MutS alpha restores base-base mismatch repair and shoulders primary responsibility for mismatch correction during replication. Predisposition to intestinal cancer requires loss of function of both Msh2/Msh6 and Msh2/Msh3 but Msh3 deficiency alone does not cause cancer predisposition. Mismatch repair deficiency can arise not only through mutation or transcriptional silencing of a mismatch repair gene, but also as a result of imbalance in the relative amounts of the MSH3 and MSH6 proteins because MutS alpha and MutS beta share a common component, MSH2. (NCI)"                       
[19572] "Initiation of DNA base excision repair (BER) involves a DNA glycosylase that binds the altered deoxynucleoside in an extrahelical position and catalyzes cleavage of the base-sugar bond. Subsequently, an AP endonuclease or AP lyase activity incises the abasic site, followed by short-patch gap-filling, excision of the base-free sugar-phosphate residue, and ligation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19573] "Nucleotide Excision Repair (NER) mends DNA regions that contain chemical adducts, such as UV-induced thymine dimers or carcinogenic adducts, which distort the DNA helix and interfere with replication and transcription. NER is targeted to actively transcribed regions of the genome. During NER in eukaryotes, shape irregularities are detected by protein complexes that slide along the DNA molecule and induce cuts on each side of a lesion several nucleotides away.  Removal of the damaged 25-30 nucleotide fragment is followed by repair synthesis and ligation."                                                                                                                                                                                                                                                                                                                                                                                                                    
[19574] "Under normoxic conditions, HIF-1alpha is rapidly degraded, whereas hypoxia, CoCl(2), or desferroxamine promote protein stabilization, thus evoking its transcriptional activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19575] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19576] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19577] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19578] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19579] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19580] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19581] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19582] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19583] "HGH Genes (Somatotropin/Prolactin Family) share a high degree of sequence identity and encode alternatively spliced diverse isoforms of Growth Hormone, a small secreted peptide hormone that affects gene expression, metabolism, and growth control. Due to alternative splicing, differential posttranslational modifications, optional binding to GHBP or alpha2-macroglobulin, and potential proteolytic processing, circulating GH shows great heterogeneity as a disulfide-linked or non-covalently associated monomer, dimer, trimer, tetramer, or pentamer in homopolymeric and heteropolymeric combinations. GH stimulates the liver and other tissues to secrete IGF-1. GH stimulates amino acid uptake and protein synthesis in muscle and other tissues and stimulates differentiation and proliferation of myoblasts. GH also stimulates mitosis, cell growth, and differentiation of other cell types. (NCI)"                                                                        
[19584] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19585] "DNA interstrand cross-links (ICLs) are very toxic to dividing cells, because they induce mutations, chromosomal rearrangements and cell death. A number of multi-step DNA repair pathways including nucleotide excision repair, homologous recombination and post-replication/translesion repair all impinge on their repair."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19586] "HeLa cells were developed from cervix adenocarcinoma of a 31-year-old Black female. The cells are positive for keratin by immunoperoxidase staining. HeLa cells have been reported to contain human papilloma virus 18 (HPV-18) sequences.  P53 expression was reported to be low, and normal levels of pRB (retinoblastoma suppressor) were found. Four typical HeLa marker chromosomes have been reported.  M1 is a rearranged long arm and centromere of chromosome 1 and the long arm of chromosome 3. M2 is a combination of short arm of chromosome 3 and long arm of chromosome 5.  M3 is an isochromosome of the short arm of chromosome 5. M4 consists of the long arm of chromosome 11 and an arm of chromosome 19. HeLa Marker Chromosomes: One copy of Ml, one copy of M2, four-five copies of M3, and two copies of M4 as revealed by G-banding patterns."                                                                                                                             
[19587] "HeLa S3 is a clonal derivative of the parent HeLa line. S3 was cloned in 1955 by T.T. Puck, P.I. Marcus, and S.J. Cieciura. This line can be adapted to grow in suspension."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19588] "HeLa/SF is a derivative of HeLa adapted to grow in serum free medium. Over time, the serum component of the medium was replaced with TCH, a defined multipurpose serum replacement."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19589] "HL-60/MX2 is a mitoxantrone resistant derivative of the HL-60 cell line. HL-60/MX2 is approximately 35 fold less sensitive to mitoxantrone than the HL-60 parental cells. HL-60/MX2 cells are cross-resistant to etoposide, teniposide, bisantrene, dactinomycin, 4'-(9-acridinylamino)methane- sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin. In addition, the HL-60/MX2 cells display slight collateral sensitivity to bleomycin. Resistance to mitoxantrone is stable for up to six months."                                                                                                                                                                                                                                                                                                                                                           
[19590] "HL-60/MX1 is a mitoxantrone resistant derivative of the HL-60 cell line. The cells were selected and subcloned in 1987 for resistance to 39 nM mitoxantrone, an anthracenedione antitumor agent. Subsequent exposure of the HL-60/MX1 cells to higher concentrations of mitoxantrone led to the emergence of cells capable of growth at 190 nM. HL-60/MX1 cells are cross resistant to etoposide, teniposide, bisantrene, actinomycin, 4'-(9-acridinylamino)methane-sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin."                                                                                                                                                                                                                                                                                                                                       
[19591] "Human EG cells are derived from the primordial germ cells, which occurs in a specific part of the embryo/fetus called the gonadal ridge, and which normally develop into mature gamates (eggs and sperm). Growing pluripotent cells derived from EG cells requires the generation of embryoid bodies, which consist of an unpredictable mix of partially differentially cell types."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19592] "Embryonic stem (ES) cells are cells derived from the inner cell mass of the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19593] "Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19594] "Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19595] "Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19596] "Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19597] "Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19598] "Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19599] "Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19600] "Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19601] "Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19602] "Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19603] "Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19604] "Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19605] "Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19607] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19608] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19609] "Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extaembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                               
[19610] "Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extaembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                               
[19611] "Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extaembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                               
[19612] "Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extaembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                               
[19613] "Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Undergoing characterization. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19614] "Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Undergoing characterization. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19615] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19616] "Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19617] "Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19618] "Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19619] "Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19620] "Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19621] "Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19622] "Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19623] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19624] "Provider: Goteborg University, Goteborg, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19625] "Provider: Goteborg University, Goteborg, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19626] "Provider: Goteborg University, Goteborg, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19627] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19628] "Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19629] "Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19630] "Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19631] "Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19632] "Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19633] "Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19634] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19635] "Provider: Maria Biotech Co. Ltd. - Maria Infertility Hospital Medical Institute, Seoul, Korea. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, alkaline phosphatase activity and telomerase activity; Differentiate in vitro into mature neuron, glia cells, muscle cells and beating cardiomyocytes; AFP was also detected in this cells. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19636] "Provider: Maria Biotech Co. Ltd. - Maria Infertility Hospital Medical Institute, Seoul, Korea. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, Oct-4, alkaline phosphatase activity and telomerase activity; Cells are negative for the cell marker SSEA-1; Cell has normal karyotype (46 XX); Differentiation in vitro into neuron; Cells were cultured in feeder-free culture condition using Matrigel coated plate. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                           
[19637] "Provider: Maria Biotech Co. Ltd. - Maria Infertility Hospital Medical Institute, Seoul, Korea. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, Oct-4, alkaline phosphatase activity and telomerase activity; Cells are negative for the cell marker SSEA-1; Cell has normal karyotype (46 XX); Differentiation in vitro into neuron; Cells were cultured in feeder-free culture condition using Matrigel coated plate. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                           
[19638] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19639] "Provider: MizMedi Hospital - Seoul National University, Seoul, Korea. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19640] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19641] "Provider: National Centre for Biological Sciences/ Tata Institute of Fundamental Research, Bangalore, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19642] "Provider: National Centre for Biological Sciences/ Tata Institute of Fundamental Research, Bangalore, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19643] "Provider: National Centre for Biological Sciences/ Tata Institute of Fundamental Research, Bangalore, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19644] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19645] "Provider: Pochon CHA University, Seoul, Korea. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19646] "Provider: Pochon CHA University, Seoul, Korea. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19647] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19648] "Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19649] "Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19650] "Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19651] "Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19652] "Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19653] "Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19654] "Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19655] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19656] "Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19657] "Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19658] "Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19659] "Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19660] "Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19661] "Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19662] "Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19663] "Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19664] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19665] "Provider: University of California, San Francisco, CA. Information from provider and not independently verified by NIH: Cells differentiate in vitro into all three germ layers; Cells are positive for cell marker Oct-4, SSEA-3, SSEA-4, and alkaline phosphatase; Cells are negative for SSEA-1; Cells will be available only for collaboration once the MTA is completed. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19666] "Provider: University of California, San Francisco, CA. Information from provider and not independently verified by NIH: Cells have normal morphology and a normal female karyotype. Cells differentiate in vitro into all three germ layers; Cells are positive for cell marker Oct-4, SSEA-3, SSEA-4, and alkaline phosphatase; Cells are negative for SSEA-1; Cells will be available only for collaboration once the MTA is completed. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19667] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19668] "Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Documented quality control includes karyotype analysis, DNA fingerprinting, mycoplasma testing, and human virus testing. Frozen vials of cells in passage 22 are available immediately. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                          
[19669] "Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro. Cells not yet ready for distribution. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                            
[19670] "Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Cells not yet ready for distribution. Publications: Thomson et al., Science 282, 1145, 1998; Amit et al., Developmental Biology 227, 271, 2000. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                        
[19671] "Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Cells not yet ready for distribution. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                            
[19672] "Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1. Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Cells not yet ready for distribution. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."                                                                                                                                                                                                                                                                                                                                                                                                            
[19673] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19674] "Protein truncation can occur as a result of those mutations that lead to the termination of mRNA translation, including (1) Nonsense mutation where single nucleotide substitution produces a stop codon (TGA, TAA or TAG) and mRNA translation stops at the point of mutation; (2) Frameshift mutation where one or more nucleotides are either inserted or deleted. If the number of bases is not divisible by 3, a change in the reading frame alters the remainder of the translation of the mRNA, and frequently a stop codon is introduced prematurely; (3) Splice site mutation where one or more nucleotides are inserted or deleted, leading to the presence of a stop codon at a splice site."                                                                                                                                                                                                                                                                                            
[19675] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19676] "The WS gene encodes WRN, a 1,432-amino acid polypeptide. WRN is a member of the RecQ family of DNA helicases that unwind duplex DNA. It can also digest DNA exonucleolytically with 3'-5' polarity. WRN may facilitate pol d-mediated DNA replication and/or DNA repair and disruption of WRN-DNA polymerase delta interaction in WS cells may contribute to the S-phase defects and/or the unusual sensitivity to a limited number of DNA damaging agents. (Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4603-8)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19677] "A program to increase cancer advocate involvement in NCI's activities.  It convenes a large network of dedicated advocates to give insight and feedback from the consumer's perspective to developing programs. (NCI press release)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19678] "Mutations of the RecQL4 gene have been identified in a limited number of patients with Rothmund-Thomson syndrome (RTS), a rare autosomal recessive genetic disorder that shows chromosomal instability, premature aging, and a high risk of mesenchymal tumors. The 13.3 kD RecQL4 protein belongs to the RecQ subfamily of helicases and contains an helicase domain with a potential ATP binding site, and the DEAH box. The RecQ4 gene is predominantly expressed in thymus and testis and at low levels in other organs such as heart, brain, placenta, pancreas, small intestine, and colon, indicating that the expression of RecQ4 gene is somewhat tissue-specific. The expression of RecQ4 gene is partially upregulated in the G1/S phase of cell cycle. RecQL4 functionally suppresses promiscuous genetic recombination and ensures accurate chromosome segregation. (Beghini A . RECQL4. Atlas Genet Cytogenet Oncol Haematol. October 2001."                                          
[19679] "S-phase onset is controlled, so that it occurs only once every cell cycle. DNA is licensed for replication after mitosis in G(1), and passage through S-phase removes the license to replicate. Licensing factors are required for licensing and central to ensuring that replication occurs once per cell cycle. (from J Biol Chem 2001 Nov 30;276(48):44905-11)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19680] "Replication initiation point (RIP) mapping detects start sites for DNA synthesis at the nucleotide level and thus monitors replication initiation events at the origin very precisely. Beyond detecting the precise positions of start sites, the application of RIP mapping in yeast and human cells has revealed a single, defined start point at which replication initiates. (J Cell Sci 2001 Feb;114(Pt 4):643-51)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19681] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19682] "HMGA1a is one of three protein products of the same gene, HMGA1, generated by alternative splicing. The HMGA1a protein contains three basic domains, named AT-hooks and an acidic C-terminal region. AT-hooks are responsible for binding to AT-rich sequences inside the minor groove of DNA. Phosphorylation of HMGA1a by both PKC and cdc-2 kinases strongly reduces its DNA binding affinity and is critical in cell cycle progression. HMGA1a activates the interferon-beta gene (IFN-beta) by functioning as the essential architectural component for the assembly and stability of the IFN-beta enhanceosome. (PMID11576996)"                                                                                                                                                                                                                                                                                                                                                               
[19683] "HMGA1b, encoded by the HMGA1 gene, preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It is involved in transcriptional regulation of the BRCA1 gene. HMGA1b overexpression accounts for BRCA1 downregulation in sporadic breast carcinomas. (From PubMed 12640109 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19684] "HMGA2 is a nuclear phosphoprotein that contains three short DNA-binding domains (AT-hooks) and a highly acidic C-terminus. The expression of the gene is cell-cycle regulated. It is likely that the HMGA2 protein acts as an architectural transcription factor, regulating the expression of one or more genes that control embryonic cell growth. Since HMGA2 binds to the minor groove of AT-rich DNA this interaction could be a target for minor groove chemotherapeutic agents in the treatment of sarcomas expressing the rearranged gene. (Int J Biochem Cell Biol 1998 Jul;30(7):761-6)"                                                                                                                                                                                                                                                                                                                                                                                                  
[19685] "Members of this family of high mobility group (HMG) proteins participate in a wide variety of nuclear processes ranging from chromosome and chromatin mechanics to acting as architectural transcription factors that regulate the expression of numerous genes. As a consequence, they function in the cell as highly connected nodes of protein-DNA and protein-protein interactions that influence a diverse array of normal biological processes including growth, proliferation, differentiation and death. Each protein contains three copies of the AT-hook, that preferentially binds to the minor groove of stretches of AT-rich sequence. HMGA genes are bona fide proto-oncogenes that promote tumor progression and metastasis when overexpressed. High constitutive HMGA protein levels are among the most consistent feature observed in all types of cancers with increasing concentrations being correlated with increasing malignancy. (Review in Gene 2001 277:63-81)"            
[19686] "The HMG-Box Family proteins are relatively abundant vertebrate DNA-binding and bending proteins that bind with structure specificity, rather than sequence specificity, and plays an architectural role in the assembly of nucleoprotein complexes. They have two homologous HMG-box DNA-binding domains connected by a short basic linker to an acidic carboxy-terminal tail that differs in length. The length (and possibly sequence) of the acidic tail may be the dominant factor in mediating the differences in properties among themselves and finely tunes the DNA-binding properties of the tandem HMG boxes, to fulfill different cellular roles. The tail is essential for structure-selective DNA-binding of the HMG boxes to DNA minicircles in the presence of equimolar linear DNA, and has little effect on the affinity for this already highly distorted DNA ligand, in contrast to binding to linear and four-way junction DNA. (J Mol Biol 2000 304:135-49)"                   
[19687] "The high mobility group N (HMGN) proteins are a family of nuclear proteins that binds to nucleosomes, changes the architecture of chromatin, and enhances transcription and replication from chromatin templates. They typically contain an NBD (Nucleosome Binding Domain) motif, which anchors these HMG proteins to the nucleosome cores to facilitate HMG-14/-17-dependent changes in higher order chromatin structure.  The intracellular organization of the HMGN (previously known as HMG-14/17) proteins is dynamic and is related to both cell-cycle and transcriptional events. These proteins roam the nucleus, perhaps as part of multiprotein complexes, and their target interactions are modulated by posttranslational modifications. Functional studies on HMGN proteins provide insights into the molecular mechanisms by which structural proteins affect DNA-dependent activities in the context of chromatin. (Trends Biochem Sci 2001 Jul;26(7):431-7)"                       
[19688] "HMGB1 is a very abundant and conserved 25-kD protein which plays a central role in the stabilization and/or assembly of several nucleoprotein multifunctional complexes through protein-protein interactions. HMGB1 is essential in a variety of DNA-related biological processes, e.g., V(D)J recombination, the initiation of transcription, and DNA repair. HMGB1 binds DNA without sequence specificity, but has a high affinity for bent or distorted DNA, and bend linear DNA. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. HMGB1 is structured into two DNA-binding HMG-box domains (A and B) plus a long highly acidic C-terminal domain. The individual A and B boxes exhibit many of the structure-specific properties of the whole protein and the acidic tail modulates the affinity of the tandem HMG boxes in HMGB1 for a variety of DNA targets. (PMID 11497996, PMID 11748221)"                                               
[19689] "HMGB3, encoded by the human HMGB3 Gene, is an high mobility group (HMG) protein, containing 2 HMG box repeats and an acidic C-terminal domain. HMGB3 is expressed predominantly in placenta. (From OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19690] "HMGB2 contains two DNA-binding HMG-box domains (A and B) and a long acidic C-terminal domain. It binds DNA without sequence specificity, but has a high affinity for bent or distorted DNA, and bend linear DNA. The individual A and B boxes (which, although broadly similar, show both structural and functional differences) exhibit many of the structure-specific properties of the whole protein. The acidic tail modulates the affinity of the tandem HMG boxes in HMG2 for a variety of DNA targets, including four-way junctions, but not distorted DNA minicircles, to which the proteins bind with very high affinity. HMGB2 appears to play important architectural roles in the assembly of nucleoprotein complexes in a variety of biological processes, for example V(D)J recombination, the initiation of transcription, and DNA repair. (Biochem Soc Trans 2001 Aug;29(Pt 4):395-401)"                                                                                            
[19691] "HMGA1c appears to be the only isoform present in normal human testis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19692] "Many vertebrates contain an additional type of HMGN protein named HMGN3 (Trip7). HMGN3a and HMGN3b are two protein isoforms with a tissue-specific expression pattern. Unique within the HMGN family, the HMGN3 transcript undergoes alternative splicing and generates two different variants, HMGN3a and HMGN3b. The shorter variant, HMGN3b, arises from an additional splice site that truncates exon V and causes a frameshift. The resulting HMGN3b protein lacks the majority of the C-terminal chromatin-unfolding domain. Both splice variants are found in many vertebrates from frogs to man and are expressed in many tissues. The pattern of tissue-specific expression differs considerably from those of HMGN1 and HMGN2 at both the mRNA and the protein level. It is possible that these nucleosome-binding proteins function as co-activators in tissue-specific gene expression. (J Biol Chem 2001 Jul 13;276(28):25959-69)"                                                     
[19693] "HMGN4, a newly discovered nuclear protein encoded by an intronless gene, is closely related to the canonical HMGN2 nucleosome-binding protein. (DNA Cell Biol 2001 May;20(5):257-64)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19694] "The XRCC2 gene at chromosome 7q36.1 encodes X-Ray Repair Cross Complementing Protein 2, a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is essential for the efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. XRCC2 also may have a role in meiosis. (from OMIM 600375, LocusLink 7516 and NCI)"                                                                                                                                                                                                                                                                                                                                                                   
[19695] "The XRCC3 gene at 14q32.3 encodes X-Ray Repair Cross Complementing Protein 3 (XRCC3), a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC3 interacts directly with RAD51 and may cooperate with RAD51 during recombinational repair. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity and exposure to UV radiation is a major risk factor for the development of malignant melanoma. DNA damage caused by UV radiation is thought to play a major role in carcinogenesis. The association between polymorphisms in DNA repair genes and the development of malignant melanoma, a T allele at position 18067 in exon 7 of the XRCC3 gene is significantly associated with melanoma development. (from OMIM 600675, LocusLink 7517 and NCI)"                                                                                
[19696] "Telomeres in human cancer cells consist of a tandem array of telomeric DNA repeats bound to a specialized telomeric proteins. Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA repair activities threaten the integrity of chromosome ends, and extensive genome instability can arise. Both telomerase and recombination can lengthen telomeres. (from PMID 11850780 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19697] "The PRKDC gene at 8q11 encodes Protein Kinase, DNA-Activated, Catalytic Subunit (PRKDC), a nuclear protein serine/threonine kinase of a multiprotein complex DNA-dependent protein kinase (DNA-PK). Two protein isoforms are produced by alternative splicing and binds DNA for catalysis. PRKDC relies on the heterodimer Ku70/Ku80 autoantigen, the DNA-binding DNA-PK component, to direct it to DNA double-stranded breaks for other discontinuities in the DNA double helix and trigger its kinase activity. PRKDC is critical for repair of DNA double strand breaks via the nonhomologous DNA end joining, telomere maintenance via telomere capping, innate immune response via V(D)J recombination (where V is variable, D is diversity, and J is joining) as well as transcriptional regulation via p53, the site-specific recombination process in developing B and T lymphocytes to generate the variable regions of immunoglobulin and T cell receptor genes."                         
[19698] "Telomere Maintenance Genes encode specialized proteins bound to telomeric DNA repeats and directly involved in maintaining/protecting chromosome telomere ends to prevent a damage response that halts cell proliferation. Telomerase, which lengthens telomeric DNA by RNA-templated addition of repeated DNA sequences, is regulated by proteins that bind to the telomeric DNA repeats and to additional proteins to assemble a higher-order telomeric complex. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19699] "Telomere capping protects chromosome ends from cellular DNA-damage responses, such as cell cycle arrest or apoptosis. Telomere capping involves multiple molecular pathways and at least four distinct structural components contribute to telomere capping: (1) the higher order telomeric DNA-protein complex, whose overall length (i.e., the number of telomeric repeats) dictates whether telomerase or nuclease can access telomeric DNA; (2) the protein complex found on the terminal few repeats; (3) the DNA-protein complex on the single stranded G-rich DNA extension of the telomere, which is most likely important for preventing DNA damage response and regulating the cell cycle dependent structure of the telomere; and (4) telomerase itself. Telomere capping is influenced by multiple, mutually reinforcing factors including telomere length, although telomere length is only one of several determinants of telomere functionality. (from PMID 11850780 and NCI)"       
[19700] "Recombination can lead to the net elongation of telomeres. The sequence at the ends of chromosomes is highly repetitive and is identical on all telomeres in a given species. The 3-prime end of one chromosome can invade a second chromosome and use the sequence of the second chromosome as a template for telomere elongation by DNA polymerase. The lagging strand can then be filled in by conventional replication mechanisms. (http://www.new-science-press.com/content/render.asp?options=nspprimer&arx_id=nsp-telomeres)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19701] "Most telomeres are maintained by telomerase. The enzymatic activity of telomerase lengthens terminal regions of eukaryotic telomeric DNA by RNA-templated addition of repeated DNA sequences to compensate for sequence loss as the cells divide. Telomerase specifically elongates the 3-prime end of a single-stranded overhang region on the G-rich 3-prime strand while the C-rich strand can be filled in by DNA polymerases. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19702] "A worldwide, decentralized network of computer networks connecting individuals and organizations to information and electronic mail services."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19703] "The glandular kallikrein gene family comprises 25-30 homologous genes that encode specific proteases involved in the processing of biologically active peptides.  Expression of glandular kallikrein, like PSA, seems to be restricted to the prostate. (from OMIM 147960 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19704] "The OGG1 gene (OGG1 family 1) encodes 8-Oxoguanine DNA Glycosylase, an enzyme in base excision repair. OGG1 incises DNA at 8-oxoguanine residues and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-n-methylformamidopyrimidine (FAPY) from damaged DNA. OGG1 also has activities of beta-lyase that nicks DNA 3-prime to the lesion and endonuclease that cleaves DNA near apurinic or apyrimidinic sites to products with 5-prime-phosphate. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common (1a/alpha, 1b, 1c, 2a/beta, 2b, 2c, 2d and 2e) and 1a is the prevalent form. OGG1 is ubiquitous and located in nucleus (isoform 1a) and mitochondria (isoform 2a). Defects in OGG1 are associated with tumor formation."                    
[19705] "The EXO1 gene at chromosome 1q42-q43 encodes Exonuclease 1, a protein with 5-prime to 3-prime double strand DNA exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different protein isoforms, a and b. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19706] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19707] "Apoptosis Inhibitor Genes encode Apoptosis Inhibitor proteins, which impede the initiation, progress, or rate of apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19708] "Apoptosis Promoter Genes encode Apoptosis Promoter proteins, which promote the initiation, progress, or rate of apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19709] "The last cell cycle stage during which the replicated daughter chromosomes separate in to separate nuclei; cytokinesis then occurs to produce separate daughter cells. M phase consists of Prophase, Metaphase, Anaphase, and Telophase. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19710] "The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family expressed during the G2/M phase of the cell cycle. BIRC5 is an interloper between cell death and cell proliferation in cancer. BIRC5 associates with the microtubules of the mitotic spindle during mitosis and any disruption results in the loss of antiapoptosis activity. BIRC5 inhibits apoptosis in B lymphocyte precursors deprived of interleukin 3 (IL-3) and may inhibit apoptosis in transformed cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19711] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19712] "The BIRC6 gene is a member of the IAP (inhibitors of apoptosis proteins) family and the ubiquitin-conjugating enzyme family. It is ubiquitously expressed as a 15-kb transcript. The protein encoded by the BIRC6 gene is expressed as a 530-kD protein in gliomas and ovarian cancers. BIRC6 may protect cancer cells from undergoing apoptosis and resist to apoptosis in the presence of anticancer drugs. BIRC6 contains a 70-amino acid cysteine- and histidine-rich baculovirus IAP repeat (BIR) and a zinc-binding RING finger."                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19713] "The protein encoded by the BIRC7 gene is a potent anti-cell death protein and caspase inhibitor. BIRC7 has pleiotropic effects on apoptosis induced by various stimuli. BIRC7's antiapoptotic activity is achieved by two separate mechanisms: one requiring TAK1-dependent JNK1 activation and the second involving caspase inhibition. Upon receipt of a death stimulus, SMAC is processed to its active form and interacts with the BIR (baculovirus IAP repeat) domain of BIRC7 to abrogate the ability of BIRC7 to inhibit apoptosis. Two splicing variants, alpha and beta, have different biological properties and tissue distribution pattern though both have a significant antiapoptotic activity. The BIRC7 gene is located at chromosome 20q13.3 on the long arm of chromosome 20."                                                                                                                                                                                                    
[19714] "This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. This gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals and inhibits apoptosis in neuronal cells."                                                                                                                                                                                                                                                                                                        
[19715] "The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) protein family that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 preventing activation of ICE-like proteases. BIRC2 inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19716] "The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. BIRC3 inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring-type zinc finger domain while the Zn binding domain is involved in protein-protein interactions in caspase inhibition and spindle assembly. BIRC3 is present in many fetal and adult tissues and mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes."                                                                                                                                                                
[19717] "The protein encoded by this gene is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Similar to BIRC2, BIRC4 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. BIRC4 also specifically inhibits two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. A novel transcript homologous to BIRC4 is expressed solely in the testis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19718] "Caspases are a highly conserved family of cysteine proteases that cleave their substrates after an aspartate residue. They play fundamental roles in the initiation and execution of apoptosis. The protein encoded by the APAF1 gene mediates processing of procaspase-9 by oligomerizing the precursors of procaspase-9 autoactivation. Once activated, caspase-9 initiates a biochemical cascade involving the downstream executioners caspase-3, -6, and -7. In addition, binding of cytochrome c to APAF1 triggers the activation of caspase-3 in the cytochrome c/dATP-dependent apoptotic pathway. APAF1 is inactivated in metastatic melanomas, leading to defects in the execution of apoptotic cell death and chemoresistance."                                                                                                                                                                                                                                                           
[19719] "The TopBP1 gene at chromosome 3q22.2 encodes Topoisomerase (DNA) II Binding Protein (TOPBP1), a 173-kD binding protein which interacts with the C-terminal region of topoisomerase II beta. TOPBP1 may stimulate catalytic activity of topoisomerase II beta through transient breakages of DNA strands. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19720] "Human FLJ20174 Gene at 3q13.31 encodes Hypothetical Protein FLJ20174, a potential homolog of sid-1 (C. elegans), a predicted transmembrane protein localized to the cell periphery, and required cell autonomously for systemic RNA interference (RNAi). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19721] "The XPA gene at chromosome 9q22.3 encodes DNA-Repair Protein Complementing XP-A Cells (XPA), the nuclear protein that has a zinc finger domain and is involved in the DNA excision repair pathway. XPA initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. XPA complements the defect in xeroderma pigmentosum (XP) group A (XP-A), an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders."                                                                                                                                                                                                                                                                                             
[19722] "The XRCC4 gene at chromosome 5q13-q14 encodes X-Ray Repair Cross Complementing Protein 4 (XRCC).  XRCC functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. The XRCC4 gene contains 8 exons, and alternative transcription initiation and alternative splicing generates several transcript variants and two protein isoforms. XRCC4 is a ubiquitously expressed protein. (NCI)"                                                                                                                                                                      
[19723] "The XRCC5 gene at 2q35 encodes a DNA repair protein XRCC5 that is ATP-dependent DNA helicase II and the 80-kilodalton subunit of the Ku heterodimer protein. It has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner and works in the 3-prime to 5-prime direction. Ku binds to free double-stranded DNA ends and Ku is the DNA-binding component of the DNA-dependent protein kinase. The Ku protein functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Individuals with SLE and related disorders produce extremely large amounts of autoantibodies to Ku subunits. (from LocusLink 7520, Swiss_Prot P13010 and NCI)"              
[19724] "Expressed in activated CD8+ T cells, in spleen, thymus, small intestine, lung, prostate, and ovary by human XCL1 Gene (Intercrine Gamma Family), 114-aa 12.5-kDa (precursor) secreted Small Inducible Cytokine C1 is similar to CCL8 and CCL3, but lacks the first and third cysteines of CC and CXC chemokines. XCL1 differs from XCL2 (separate gene) by only 2 amino acids; XCL1 encodes Asp7, Lys8 (mature protein) instead of His, Arg as in XCL2. XCL1 is chemotactic for CD4+ and CD8+ T cells, but not for monocytes or neutrophils, and induces increased intracellular calcium in peripheral lymphocytes; XCL1 induces migration of cells expressing XCR1. Small (8-14 kD), mostly basic, chemokines interact with 7-transmembrane G protein-coupled receptors and regulate cell trafficking of leukocytes, as well as development, homeostasis, and immune system function. (NCI)"                                                                                                       
[19725] "The exact duplication of a genome once per cell division is required of every proliferating cell. To achieve this goal, eukaryotes adopt a strategy that limits every replication origin to a single initiation event within a narrow window of the cell cycle by temporally separating the assembly of the pre-replication complex (pre-RC) from the initiation of DNA synthesis. A key component of the pre-RC is the hexameric MCM complex. An elaborate mechanism recruits the MCM complex to replication origins, and a regulatory chain reaction converts the poised, but inactive, MCM complex into an enzymatically active helicase. (from PMID 11282021 and NCI)"                                                                                                                                                                                                                                                                                                                          
[19726] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19727] "The MCM proteins are essential replication initiation factors. The best known among them are a family of six structurally related proteins, MCM2-7, which are evolutionally conserved in all eukaryotes. The MCM2-7 proteins form a hexameric complex. This complex is a key component of the prereplication complex that assembles at replication origins during early G1 phase. The MCM2-7 proteins may be involved not only in the initiation but also in the elongation of DNA replication. Orchestration of the functional interactions between the MCM2-7 proteins and other components of the prereplication complex by cell cycle-dependent protein kinases results in initiation of DNA synthesis once every cell cycle. (from PMID 10872463 and NCI)"                                                                                                                                                                                                                                     
[19728] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19729] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19730] "Replication Initiation Genes encode proteins directly involved in initiation of DNA replication. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19731] "DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed of six protein subunits and binds to the ARS Consensus Sequence (ACS) of Origins of Replication in an ATP-dependent manner. While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6) may be required for initiation of DNA replication and are essential for viability."                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19732] "Licensing Factor Genes encode Licensing Factors that are required, after a prior round of mitosis, in G(1) for DNA replication licensing, are removed after passage through S-phase, and are central to ensuring that replication occurs once per cell cycle. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19733] "The MCM2 gene at 3q21 encodes a 100-kD nuclear protein that is a member of the MCM family. MCM2 allows the DNA to undergo a single round of replication per cell cycle and is required for the entry in S phase and for cell division. MCM4, MCM6, and MCM7 form a stable complex with which MCM2 is loosely associated. The trimeric complex of MCM4, -6, and -7 has ATPase and DNA helicase activities, which is involved in the initiation of DNA replication as a DNA unwinding enzyme. The presence of MCM2 disturbs the assembly of MCM4, MCM6, and MCM7 proteins to inhibit the DNA helicase activity. Through specific binding of MCM2 with histone H3, the complex binds chromatin. In addition, the CDC7L1 kinase complex triggers S phase by directly activating the replication initiation complex assembled at the origins. Phosphorylation of MCM2 and MCM3 in the MCM complex by the CDC7L1 kinase complex converts the inactive MCM complex into an active helicase."               
[19734] "The MCM4 gene at 8q12-q13 encodes a 97-kD protein that is a member of the MCM family. MCMs are a family of proteins related to ATP-dependent helicases that bind to origin recognition complexes and are required not only for the initiation of DNA replication but also for preventing over-replication in eukaryotic cells. MCM4 forms a stable complex with MCM6 and MCM7 and is loosely associated with MCM2. Through specific binding of MCM2 with histone H3, the complex binds chromatin. Both ATPase and DNA helicase activities are associated with the trimeric MCM4, -6, and -7 complex, which may be involved in the initiation of DNA replication as a DNA unwinding enzyme. MCM4 is highly phosphorylated in mitotic cells and phosphorylation of the amino-terminal region of MCM4 at specific sites by the cyclin A/Cdk2 leads to loss of MCM4, -6, -7 DNA helicase activity. This inactivation of helicase activity is a part of the system for regulating DNA replication. (NCI)"
[19735] "The MCM5 gene at 22q13.1 encodes a 82-kD protein that is a member of the MCM family. MCMs are a family of proteins related to ATP-dependent helicases that bind to origin recognition complexes and are required for initiation of DNA replication. Essentially all nuclear MCM5 forms a stable dimeric complex with MCM3 and MCM3 is associated with the replication-specific DNA polymerase alpha-primase complex. MCM3 acetylation by an acetyltransferase MCM3AP might regulate DNA replication. In addition, MCM proteins are associated with RNA polymerase II (Pol II) holoenzyme as components of the Pol II transcriptional apparatus for transcription. MCM5 directly interacts with the transcription activation domain (TAD) of Stat1 and enhances Stat1-mediated transcription activation. The growth-regulated expression of the MCM5 gene is primarily regulated by E2F through binding to multiple E2F sites in the promoter."                                                      
[19736] "The MCM6 gene at 2q21 encodes a 105-kD protein that is a member of the MCM family. MCMs are related to ATP-dependent helicases that bind to origin recognition complexes and are required not only for the initiation of DNA replication but also for preventing over-replication in eukaryotic cells. MCM6 forms a stable complex with MCM4 and MCM7. Both ATPase and DNA helicase activities are associated with the trimeric MCM4, -6, and -7 complex, which is involved in the initiation of DNA replication as a DNA unwinding enzyme. MCM6 is expressed in a wide variety of human adult and fetal tissues and not restricted in its tissue distribution. MCM6 transcription is repressed in quiescent cells but is rapidly induced at the G1/S phase by growth factor stimulation with four putative E2F binding motifs at the 5' regulatory region of the promoter. MCM6 protein level oscillates during the cell cycle, with a peak at the G1/S phase. (NCI)"                              
[19737] "The MCM3 gene at 6p12 encodes Minichromosome Maintenance Protein 3, a 91-kD protein that is a member of the MCM family. MCMs are a family of proteins related to ATP-dependent helicases that bind to origin recognition complexes and are required for initiation of DNA replication. MCM3 is associated with the replication-specific DNA polymerase alpha-primase complex and MCM3 acetylation by an acetyltransferase MCM3AP might regulate DNA replication. In addition, MCM proteins are associated with RNA polymerase II (Pol II) holoenzyme as components of the Pol II transcriptional apparatus for transcription. MCM3 complexes with essentially all nuclear MCM5 to form a stable dimeric and MCM5 directly interacts with the transcription activation domain (TAD) of Stat1 to enhance Stat1-mediated transcription activation. (NCI)"                                                                                                                                              
[19738] "The MCM7 gene at 7q21.3-q22 encodes a 81-kD protein of the MCM family. MCMs are ATP-dependent helicases that bind to origin recognition complexes and required for the initiation of DNA replication as well as for preventing over-replication. MCM6 forms a stable complex with MCM4 and MCM7. The trimeric MCM4, -6, and -7 complex is involved in the initiation of DNA replication as a DNA unwinding enzyme. At the final step in sequential assembly of an active initiation complex, CDC45 binds directly to MCM7 and the p70 subunit of DNA polymerase alpha. The p70 subunit, which has no enzymatic activity, forms a tight complex with the p180 catalytic subunit of DNA polymerase alpha. CDC45 leads DNA polymerase alpha, the only enzyme capable of starting DNA synthesis de novo, to the origins of DNA replication through binding with MCM7 and the p70 subunit. MCM7 transcription is a direct target of the MYCN oncoprotein in neuroblastoma. (NCI)"                        
[19739] "The CDC45L gene at 22q11.2 encodes a 66-kD protein that interacts with MCM7 and DNA polymerase alpha in the loading of DNA polymerase alpha onto chromatin at the final step in sequential assembly of an active initiation complex for replication. CDC45 binds directly to the p70 subunit of DNA polymerase alpha, which has no enzymatic activity. CDC45 may lead DNA polymerase alpha, the only enzyme capable of starting DNA synthesis de novo, to the origins of DNA replication through binding with MCM7 and the p70 subunit. CDC45 is widely expressed with highest levels in adult testis and thymus and in fetal liver. The level of Cdc45L mRNA peaks at G1-S transition, but total protein amount remains constant. CDC45 is expressed in multiple tissues during embryogenesis, including neural crest-derived structures. One copy of this gene is deleted in patients with DiGeorge syndrome. (From PMID and NCI)."                                                               
[19740] "DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed of six protein subunits and binds to the ARS Consensus Sequence (ACS) of Origins of Replication in an ATP-dependent manner. While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6) may be required for initiation of DNA replication and are essential for viability. The protein encoded by the ORC2L gene is a 72-kD protein that forms a complex with ORC1L in vivo and has highest expression levels in testes. Expression of ORC2L is not regulated during different phases of cell proliferation. The human ORC2L gene is located at 2q33 on the long arm of chromosome 2."                                                                                                                                                          
[19741] "The CDT1 gene encodes DNA Replication Factor (CDT1), which is essential for DNA replication and chromatin licensing. Geminin inhibits inappropriate origin firing by targeting CDT1. CUL4 prevents aberrant reinitiation of DNA replication, at least in part, by facilitating the degradation of CDT1. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19742] "The CDC6 gene encodes CDC6 Cell Division Cycle 6 Homolog, which is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cycle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cycle is regulated through its phosphorylation by Cdks. Transcription of this protein is regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                 
[19743] "The Mcm10 gene encodes a 98-kD protein that interacts with ORC and the MCM2-7 complex. MCM10 is not part of the MCM2-7 complex and shares no significant sequence homology with the MCM proteins in the complex. MCM10 may assist in releasing replication forks from the origin of replication through interactions with those proteins to release the MCM2-7 complex for triggering DNA replication. Though human MCM10 is not a component of the prereplicative complex, it is involved in S phase progression. Human MCM10 binds chromatin during S phase and dissociates in G(2) phase. Human MCM10 is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. This gene is located at chromosome10p13 on the short arm of chromosome 10."                                                                                                                                                                                                                              
[19744] "The CDC7 gene encodes CDC7 Cell Division Cycle 7, which is predominantly localized in the nucleus and is a cell division cycle protein with kinase activity. Although expression levels of this protein appear constant throughout the cell cycle, the protein kinase activity appears to increase during S phase. This protein is essential for initiation of DNA replication and plays a role in regulating cell cycle progression. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Additional transcript sizes have been detected, suggesting the presence of alternative splicing. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                              
[19745] "Growth factor and E2F-regulated, widely expressed (2.5-kb transcript) 33-kb 12-exon human ASK Gene at 7q21.3 encodes 674-aa 77-kD nuclear Activator of S Phase Kinase, a cyclin-like regulatory subunit of CDC7L1 kinase involved in G1/S transition. ASK mRNA and protein are low in G1, peak in S phase, and reduce in G2/M; ASK is extensively phosphorylated during S phase. Containing a bipartite NLS, conserved motifs N (N-terminus) and C (central region), and 2 PEST sequences, ASK appears essential for entry into S phase. Motif C is essential for CDC7L1 catalytic subunit interaction with ASK, a major activator of CDC7L1 kinase activity on MCM2.  (NCI)"                                                                                                                                                                                                                                                                                                                       
[19746] "Transcriptionally repressed by E2F in quiescent cells and activated by G1 cyclin-dependent kinase growth stimulation, human ORC1L Gene (ORC1 Family) encodes 861-aa 97-kDa nuclear Origin Recognition Complex Subunit 1, the largest of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. Selectively phosphorylated during mitosis and unlike other ORC subunits, ORC1L levels vary during the cell cycle, regulated by ubiquitin-mediated proteolysis after replication initiation. Also involved in transcriptional silencing, ORC1L may interact with MYST histone acetyltransferase 2. (NCI)"                        
[19747] "DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed of six protein subunits and binds to Origins of Replication. While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6) may be required for initiation of DNA replication. The protein encoded by the ORC4L gene is a 50-kD protein that has a putative nucleotide triphosphate binding motif. ORC4L associates with multiple cellular proteins, including ORC2L, in vivo. The human ORC4L gene is located at chromosome 2q22-q23 on the long arm of chromosome 2."                                                                                                                                                                                                                                                                            
[19748] "DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed of 6 protein subunits and binds to Origins of Replication. While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6) are required for initiation of DNA replication. The ORC5 gene at 7q22.1 encodes the bulk of protein in an insoluble nuclear fraction. The alternatively spliced ORC5T protein forms a complex with ORC4L but not with ORC2L and regulates the assembly of different ORC subcomplexes. ORC5 and the alternatively spliced ORC5T transcripts are abundant in spleen, ovary, and prostate in addition to tissues with high levels of DNA replication like testes and colon mucosa. The ORC5L gene does not function as a tumor suppressor in patients with myeloid neoplasms. (from OMIM 602331 and NCI)"                   
[19749] "DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed of 6 protein subunits and binds to Origins of Replication in an ATP-dependent manner. While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6) are required for initiation of DNA replication. The ORC6L gene at 16q12 encodes a 28-kD protein whose expression level does not change through the cell cycle. Like ORC1, ORC6 is localized in the nucleus along with the other ORC subunits but only a small fraction of human ORC1 and ORC6 is associated with a subcomplex of ORC2, 3, 4, and 5. ORC6 also co-immunoprecipitate with several cellular proteins, including a 65-kDa protein that is hyperphosphorylated in G(1) and dephosphorylated in mitosis. (from J Biol Chem and NCI)"                                                
[19750] "DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed of 6 protein subunits and binds to Origins of Replication. While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6) may be required for initiation of DNA replication. The ORC3L gene at 6q14.3-16.1 encodes an 80-kD protein that contains a nuclear localization signal and helix-loop-helix motifs. Human ORC2, -3, -4, and -5 form a core complex. The N-terminal region of ORC3 interacts directly with the C-terminal region of ORC2 and the C-terminal region of ORC3 is necessary to bring ORC4 and ORC5 into the core ORC2-5 complex. ORC3L is important for the G(1)-S transition in mammalian cells and might have other activities than replication initiation because it is also detected in non-proliferating cells. (NCI)"    
[19751] "family of polypeptide growth factors produced by peripheral target tissues as well as the nervous system, which are critical to neuronal growth, regeneration, survival, and differentiation. (CSP2000)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19752] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19753] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19754] "Encoded by WNT Family Genes, secreted structurally related signaling WNT Family Proteins are implicated in oncogenesis and in several developmental processes, including regulation of cell fate and embryonic patterning. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19755] "The geminin gene at 6p22.1 encodes a 25-kD protein that inhibits DNA replication during S, G2, and M phases by sequestering CDT1, a replication initiation factor necessary for MCM loading, to prevent the incorporation of MCM complex into prereplication complex. Geminin has a destruction box sequence (RRTLKVIQP) and is ubiquitinated by the anaphase-promoting complex. Geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Geminin may also inhibit inappropriate origin firing by targeting CDT1. In the normal cell cycle, CDT1 is present only in G1 and S phases, whereas geminin is present in S and G2 phases. (from OMIM 602842 and NCI)"                                                                                                                                                                                                                                                                                   
[19756] "The Protein Phosphatase 2A Subunit Genes encodes 3 subunits (A, B, and C) of Protein Phosphatase 2A (PP2A) holoenzyme, a heterotrimeric serine/threonine phosphatase. The structural A subunit and the catalytic C subunit form a catalytic core, while substrate specificity is directed by the B subunit. PP2A exerts regulatory control over the initiation of DNA replication and has a particularly complex set of regulatory subunits controlling its function and localization."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19757] "Human PR48 Gene (PP2A Regulatory Subunit B Family) encodes 414-aa nuclear Protein Phosphatase 2A 48kDa Regulatory Subunit, a B regulatory subunit of PP2A. PR48 specifically interacts with the N-terminal region of and dephosphorylates CDC6, modulating initiation of DNA replication and cell cycle control. A major heterotrimeric Ser/Thr phosphatase implicated in negative control of many cellular processes including cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A that may differ in substrate specificity, subcellular location, or tissue specific expression. (NCI)"                       
[19758] "The PPP2CA gene at chromosome 5q23-q31 encodes a 36-kD protein and catalytic subunit that is common to all forms of Type 2A protein phosphatase (PP2A) PPP2CA forms two distinct complexes, alpha with a structural PR65/A subunit and beta with an alpha4 protein. The PR65/A-PPP2CA dimer may further associate with a third regulatory subunit (PR54, PR55, PR72, PR74, PR130, etc.) and form a specific trimeric holoenzyme. Three families of regulatory subunits control substrate selectivity and phosphatase activity and target PP2A holoenzymes to their substrates. Phosphorylation, carboxyl methylation, inhibition by intracellular protein inhibitors, and stimulation by ceramide also regulate PPP2CA function. Phosphorylation of either threonine or tyrosine results in inactivation of the phosphatase, whereas auto-dephosphorylation acts as a mechanism for reactivation. (NCI)"                                                                                            
[19759] "Type 2A protein phosphatase (PP2A) comprises a diverse family of phosphoserine- and phosphothreonine-specific enzymes ubiquitously expressed in eukaryotic cells. PP2A dephosphorylates protein kinases and transcription factors, and regulates most major metabolic pathways, as well as translation, transcription, and control of transition from G2 to the M phase of the cell cycle. PP2A consists of three subunits, a catalytic C subunit and a structural/regulatory A subunit, which form the core enzyme, and a regulatory B subunit that binds to the core enzyme yielding the holoenzyme. Both the A and B subunits exist as two isoforms, alpha and beta. The combination of these different subunits could give rise to many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. The PPP2CB gene at 8p12-p11.2 encodes the beta isoform of the catalytic subunit of PP2A. (NCI)"                                      
[19760] "(MAH-no-KLO-nul AN-tih-BAH-deez) Laboratory-produced substances that can locate and bind to cancer cells wherever they are in the body. Many monoclonal antibodies are used in cancer detection or therapy; each one recognizes a different protein on certain cancer cells. Monoclonal antibodies can be used alone, or they can be used to deliver drugs, toxins, or radioactive material directly to a tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19761] "Ubiquitously expressed (heart and skeletal muscle highest), human PPP2R5A Gene (PP2A Subunit B Family) encodes serine phosphorylated 486-aa 56-kDa cytoplasmic Protein Phosphatase 2 Regulatory Subunit B Alpha, a subunit of PP2A. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)"                                                                                                                                               
[19762] "Type 2A protein phosphatase (PP2A) is a diverse family of phosphoserine- and phosphothreonine-specific enzymes ubiquitously expressed in eukaryotic cells. PP2A consists of three subunits, a catalytic C subunit and a structural A subunit, which form the core enzyme, and a regulatory B subunit that binds to the core enzyme yielding the holoenzyme. Both the A and B subunits exist as two isoforms, alpha and beta, whereas the B subunits fall into three families. The combination of these different subunits could give rise to many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. The PPP2R5B gene encodes the beta subunit in the B56 family of related PP2A regulatory subunits. The PPP2R5B gene at chromosome 11q13 is expressed at highest levels in the brain and the expression increases when neuroblastoma cells are induced to differentiate with retinoic acid. (from OMIM 601643 and NCI)"           
[19763] "Type 2A protein phosphatase (PP2A) is a diverse family of phosphoserine- and phosphothreonine-specific enzymes ubiquitously expressed in eukaryotic cells.  PP2A consists of three subunits, a catalytic C subunit and a structural A subunit, which form the core enzyme, and a regulatory B subunit that binds to the core enzyme yielding the holoenzyme.  Both the A and B subunits exist as two isoforms, alpha and beta, whereas the B subunits fall into three families.  The combination of these different subunits could give rise to many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression.  The PPP2R5C gene at chromosome 14q32.2 encodes the gamma subunit in the B56 family of related PP2A regulatory subunits.  This gene is expressed at highest levels in skeletal and cardiac muscle and there are at least 3 splice variants. (NCI)"                                                                          
[19764] "Type 2A protein phosphatase (PP2A) is a diverse family of phosphoserine- and phosphothreonine-specific enzymes. PP2A consists of three subunits, a catalytic C subunit and a structural A subunit, which form the core enzyme, and a regulatory B subunit that binds to the core enzyme yielding the holoenzyme. The combination of these different subunits gives rise to many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. The PPP2R5D gene at 6p21.1 encodes the 70-kD delta subunit in the B56 family of related PP2A regulatory subunits. Its expression varies with the cell cycle, present in both cytoplasm and nucleus in interphase cells but concentrated in the nucleus of mitotic and recently divided cells. PPP2R5D is highly expressed in the adult brain, and mRNA increases 3- to 5-fold when neuroblastoma cell lines are induced to differentiate by retinoic acid treatment. (from OMIM 601646 and NCI)" 
[19765] "Type 2A protein phosphatase (PP2A) is a diverse family of phosphoserine- and phosphothreonine-specific enzymes. PP2A consists of three subunits, a catalytic C subunit and a structural A subunit, which form the core enzyme, and a regulatory B subunit that binds to the core enzyme yielding the holoenzyme. The combination of these different subunits gives rise to many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. The PPP2R5E gene at chromosome 7p12-p11.2 encodes the 55-kD epsilon subunit in the B56 family of related PP2A regulatory subunits. PPP2R5E is predominantly cytoplasmic, excluded from the nucleus and concentrated in a perinuclear spot of unknown function. There are two isoforms of the PPP2R5E mRNA. (from OMIM 601647 and NCI)"                                                                                                                                                           
[19766] "Type 2A protein phosphatase (PP2A) is a diverse family of phosphoserine- and phosphothreonine-specific enzymes. PP2A consists of three subunits, a catalytic C subunit and a structural A subunit, which form the core enzyme, and a regulatory B subunit that binds to the core enzyme yielding the holoenzyme. The combination of these different subunits gives rise to many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. The PPP2R4 gene at 9q34 encodes a specific and reversible activator that stimulates phosphotyrosyl phosphatase activity of PP2A core heterodimer in the presence of ATP and Mg(+2). The pPP2R4 gene has a TATA-less promoter that is GC-rich and containing four Sp1 sites. PPP2R4 is widely expressed and four isoforms are produced by alternative slicing. This gene is probably not involved in chronic myeloid leukemia. (From OMIM, LocusLink and NCI)"                                    
[19767] "VAV Family Genes (VAV1, VAV2, and VAV3) encode VAV proteins that respond to similar cell surface receptor tyrosine kinases as GEFs for Rho/Rac family GTPases, which activate pathways leading to actin cytoskeletal rearrangements, transcriptional alterations, cell differentiation, and/or cell proliferation. VAV proteins contain CH, DH, PH, SH2, SH3, and zinc-dependent phorbol-ester and DAG binding domains. VAV1 is expressed exclusively in hematopoietic cells, while VAV2 and VAV3 are more broadly expressed. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19768] "The BCL-2 Gene Family encodes proteins that contain Bcl-2 homology (BH) domains (1, 2, 3, or 4), involved in interactions among apoptotic protein factors that participate in programmed cell death. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19769] "A BCL2-related gene, designated BCLX.  It can function as a BCL2-independent regulator of programmed cell death (apoptosis). Alternative splicing resulted in 2 distinct BCLX mRNAs. The protein product of the larger mRNA (BCLXL) was similar in size and predicted structure to BCL2.  It inhibits cell death upon growth factor withdrawal at least as well as BCL2 in a transfected IL3-dependent cell line.  On the other hand, the smaller mRNA species (BCLXS) encodes a protein that inhibits the ability of BCL2 to enhance the survival of growth factor-deprived cells."                                                                                                                                                                                                                                                                                                                                                                                                                
[19770] "This gene encodes a member of the BCL-2 protein family. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19771] "Encodes an antiapoptotic Bcl-2 family member that presents in neutrophils"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19772] "Encodes a BCL2 related protein that induces apoptosis.  May cause the mitochondrial voltage-dependent anion channel to open and release cytochrome c into the cytoplasm resulting in caspase activation. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19773] "The protein encoded by this gene is a member of the BCL-2 family. It positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19774] "Bcl-X has two isoforms, Bcl-XL (long) a 241 amino acid protein and Bcl-XS (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the Bcl-2 family."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19775] "The protein encoded by this gene belongs to the BCL-2 protein family. It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests the roles of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of the apoptosis in thymocyte-negative selection. Eight alternatively spliced transcript variants of this gene have been reported. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                  
[19776] "The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2, BCLXL, Epstein-Barr virus BHRF1, and adenovirus E1B 19-kD in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK. (from RefSeq Summary and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19777] "Activator of apoptosis HRK regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                               
[19778] "BID (BH3 Interacting domain Death agonist) encodes a death agonist that heterodimerizes with either agonists (BAX) or antagonists (BCL2). BID is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19779] "Genes that code for transcription factors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19780] "Encoding 1872-aa 250-kD nuclear TAF(II)250, the largest subunit of TFIID, 98-kb human TAF1 Gene at Xq13.1 expresses two transcript isoforms: variant 2 lacks codons for 21 internal amino acids. Perhaps phosphorylated by casein kinase II, TAF1 contains an HMG box and two bromodomains with highly charged helical bundles that bind to diacetylated histone H4 tails. Similar to Drosophila TAFII-230 and yeast TAFII-111 and TAF145, TAF1 contains N- and C-terminal Ser/Thr kinase domains that auto- and transphosphorylate the basal TFIIF large subunit. TAF1 possesses acetyl transferase activity, acts as an ubiquitin-conjugating enzyme, binds to core promoter transcription start sites, and interacts with TBP, other TAFs, and transcriptional regulators in TFIID assembly and RNA Pol II transcription initiation. Essential for G1 progression, TAF1 links control of transcription to the cell cycle. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                           
[19781] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19782] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19783] "Substances made by the body that function to regulate cell division and cell survival. Some growth factors are also produced in the laboratory and used in biological therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19784] "Epidermal Growth Factor, encoded by the EGF gene, has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin. The EGF precursor is believed to exist as a membrane-bound molecule that is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19785] "Peptide isolated from the pituitary gland and from the brain. It is a potent mitogen which stimulates growth of a variety of mesodermal cells including chondrocytes, granulosa, and endothelial cells. The peptide may be active in wound healing and animal limb regeneration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19786] "Growth factors which promote the development of blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19787] "Human Hepatocyte Growth Factor is also known as Scatter Factor and Hepatopoeitin A.  HGF is a potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types, including renal tubular epithelial cells, epidermal keratinocytes and melanocytes.  A single chain precursor is cleaved to 70 kD and 30kD chains that are linked by one disulfide bond. Both the single chain and cleaved form are active."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19788] "Human erythropoietin is an acidic glycoprotein hormone with a molecular mass of 34 kD. As the prime regulator of red cell production, its major functions are to promote erythroid differentiation and to initiate hemoglobin synthesis.[supplied by OMIM](LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19789] "Angiogenin is an exceedingly potent mediator of new blood vessel formation.  Expressed in many cells, angiogenin is a homologue of pancreatic ribonuclease.  The ribonucleolytic active site of Angiogenin is critical for angiogenic activity.  (from OMIM 105850 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19790] "Amphiregulin is a heparin-binding, heparin-inhibited member of the epidermal growth factor family and an autocrine growth factor for human keratinocytes. It seems to play an important role in mammary epithelial cell growth regulation. It shows overexpression in various tumors.  It is encoded by the AREG gene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19791] "Betacellulin is a member of the EGF family of growth factors; a potent mitogen for retinal pigment epithelia and vascular smooth muscle cells. Betacellulin effects may be mediated by the EGF receptor and/or related receptors. The precursor form is a type I membrane protein that contains one EGF-like domain and is synthesized in several tissues and tumor cells. Betacellulin from pancreatic beta cells could play a role in the vascular complications associated with diabetes. (from Swiss-Prot P35070 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19792] "Neuregulin (heregulin) polypeptides have been shown to interact with and activate the ErbB2, ErbB3 and ErbB4 receptor proteins, and have been found to be essential for the normal development of the cardiovascular, pancreatic and nervous systems. Neuregulins are involved in the normal development of mammary gland, are secreted by breast cancer cells, and can alternatively promote or inhibit breast cancer cell division."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19793] "A member of the heparin-binding growth factor family, FGF5 is expressed in neonatal brain.  Two isoforms (long and short) are produced by alternative splicing.  (from OMIM 165190 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19794] "Fibroblast Growth Factor 6 is encoded by the HST2 proto-oncogene and belongs to the heparin-binding growth factor family.  FGF6 exhibits strong mitogenic and angiogenic properties and may be expressed by cells with platelet/megakaryocytic differentiation potential.  (from Swiss-Prot P10767 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19795] "Fibroblast Growth Factor 7 (Keratinocyte Growth Factor) is a member of the fibroblast growth factor family that stimulates the growth of epithelial cells, but lacks mitogenic activity on fibroblasts or endothelial cells.  FGF7 is a single polypeptide chain of about 28 kD that has predominant activity in keratinocytes.  (from OMIM 148180 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19796] "Synthesized by mesenchymal cells, Macrophage Colony-Stimulating Factor is a 70 kD disulfide-bonded homodimeric glycoprotein cytokine that binds to FMS (a specific high affinity receptor) and stimulates survival, proliferation, and differentiation of committed hematopoietic cells of the related granulocyte and monocyte-macrophage lineages.  Three isoforms of M-CSF result from alternative splicing.  The active forms may be produced by proteolytic cleavage; precursors may exist as integral membrane proteins.  Isoform 1 may undergo rapid proteolytic cleavage to yield an extracellular growth factor.  Isoform 3 may exist as an integral membrane protein that undergoes slow proteolysis at the cell surface to yield a soluble growth factor.  (from OMIM 120420, SWISS-PROT P09603, and NCI)"                                                                                                                                                                               
[19797] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19798] "(in-ter-LOO-kin) IL-3. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease) that enhances the immune system's ability to fight tumor cells. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19799] "A naturally-occurring hematopoietic cytokine (also called stem cell factor, steel factor, and mast cell growth factor).  In conjunction with autologous stem cell transplantation, kit ligand restores red blood cell populations in chemotherapy-treated patients by inhibiting the caspase-induced apoptosis of erythroid precursor cells.  In vitro, kit ligand induces migration of some cancer cells in the presence of extracellular matrix components and, in vivo, may increase metastatic invasiveness and vasculogenesis. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19800] "A colony-stimulating factor that stimulates the production of blood cells, especially platelets, during chemotherapy. It is a cytokine that belongs to the family of drugs called hematopoietic (blood forming) agents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19801] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19802] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19803] "Nerve growth factor.  A peptide of 118 amino acids with both chemotropic and chemotrophic properties for sympathetic and sensory neurons.  Found in a variety of peripheral tissues, NGF attracts neurites to the tissues by chemotropism, where they form synapses.  NGF was the first of a family of nerve tropic factors to be discovered."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19804] "Brain-Derived Neurotrophic Factor is a member of the nerve growth factor family.  It exerts trophic action on retinal, cholinergic, and dopaminergic neurons in the brain and on motor and sensory neurons in the peripheral nervous system.  Target cells regulate neuronal survival by producing neurotrophic factors, such as NGF and BDNF, which show sequence similarity.  Proforms of NGF and BDNF are secreted and cleaved by plasmin serine protease and matrix metalloproteinases (MMP7, MMP3); proforms preferentially activate p75(NTR) to mediate apoptosis and mature forms activate TRK receptors to promote survival.  Huntingtin up regulates transcription of BDNF.  Mutated Huntingtin decreases production of BDNF leading to neuronal death.  (from OMIM 113505 and NCI)"                                                                                                                                                                                                       
[19805] "Glial Cell-Line Derived Neurotrophic Factor contains seven conserved cysteine residues spaced similar to the TGF-beta superfamily.  GDNF is processed to a mature secreted form, which occurs as a homodimer that promotes the survival and differentiation of dopaminergic neurons, can rescue motor neurons from programmed cell death, and protects cells from the neurotoxin MPTP.  GDNF is a ligand for the RET gene product.  (from OMIM 600837 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19806] "Parathyroid Hormone-Related protein signals through its receptor PTHR1, regulating endochondral bone development and epithelial-mesenchymal interactions.  PTHRP is an anti-proliferative factor that regulates epidermal cell growth.  Because of its structural homology with PTH and binding to the PTH/PTHRP receptor, PTHRP can mimic the action of PTH, but has evolved to regulate local tissue functions, in contrast to the systemic function of parathyroid hormone.  To carry out its diverse biologic roles, PTHRP functions as a poly-hormone that gives rise to several biologically active peptides, each of which presumably has its own receptor.  To broaden its repertoire even further, it appears to have intracrine effects in the nucleus of cells that produce it, in addition to having autocrine, juxtacrine, paracrine, and possibly endocrine effects after secretion.  (from OMIM 168470 and NCI)"                                                                     
[19807] "Expressed in platelets, human Platelet-Derived Growth Factor (PDGF/VEGF Family) is a mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released upon wounding to stimulate adjacent cell growth. PDGF can exist as antiparallel disulfide-linked homodimers (PDGFA, PDGFB) or heterodimers (PDGFA/PDGFB) that bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19808] "Expressed as 2 alternative isoforms in platelets by human PDGFB Gene (PDGF/VEGF Family), 241-aa 27-kDa (precursor) Platelet-Derived Growth Factor-Beta Chain is a potent mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released by platelets upon wounding to stimulate adjacent cell growth. PDGFB can exist as either antiparallel disulfide-linked homodimers or heterodimers with Platelet-Derived Growth Factor Alpha. A-A, B-B, and A-B, dimers can bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. PDGFB mutations are associated with meningioma. Reciprocal t(17;22)(q22;q13) translocations with COL1A1 result in unregulated growth factor expression and are associated with DFSP. (NCI)"                                                                                                                                                                     
[19809] "Encoded by human VEGF Gene (PDGF/VEGF Family), widely expressed 232-amino acid 27 kD (precursor) VEGF exhibits seven isoforms: VEGF206, -189, -183, -165/VEGF, -148, -145, and -121. VEGF121 is acidic; VEGF165 is more basic and binds heparin/ECM; VEGF189 is very basic. VEGF is a disulfide-linked, 41-45 kD secreted homodimeric glycoprotein angiogenic growth factor; it may heterodimerize with PLGF. VEGF inhibits apoptosis and promotes endothelial proliferation, cell migration, and vascular permeabilization. VEGF interacts with VEGFR1/FLT-1 and VEGFR2/KDR/FLK1 receptors. VEGF145 may inhibit -165 binding to FLK1. Collapsin/semaphorin receptor Neuropilin-1 (VEGF165R) mediates neuronal cell guidance and binds VEGF165 and -145, but not -121; it enhances VEGF165/KDR binding and chemotaxis.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                     
[19810] "(in-ter-LOO-kin) IL-6. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease). These substances are normally produced by the body, but they can also be made in the laboratory for use in treating cancer and other diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19811] "A secreted growth factor that is mitogenic for endothelial, epithelial, and fibroblast cells but can also induce neurite outgrowth.  It functions as a growth factor during neonatal brain development, for primate trophoblast formation, and during tumor invasion, angiogenesis, and metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19812] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19813] "Transforming growth factor alpha (TGFA) stimulates the growth and proliferation of cells, and its overexpression has been correlated with patient survival in a variety of tumors, including squamous carcinoma of the esophagus. In esophageal adenocarcinoma patients who received high-dose radiation and chemotherapy those with tumors that persistently expressed or that increased TGFA expression had a worse prognosis. (from Int J Radiat Oncol Biol Phys. 1995;31:567-9)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19814] "Factor synthesized in a wide variety of tissues including platelets, placenta, and both normal and transformed cell lines. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta also has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. There are at least three forms of TGF-beta: TGF-beta1, TGF-beta2, and TGF-beta1.2. The latter is a heterodimer made up of both TGF-beta1 and TGF-beta2. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19815] "Disulfide-linked homo- and heterodimeric growth factors (Activin A, Activin B, Activin AB) of the TGF Family with effects on a range of cell types in addition to promoting FSH release in gonadal sites, depending on subunit composition. Composed of Beta-A and Beta-B subunits."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19816] "TGFB is a multifunctional peptide cytokine that controls proliferation, differentiation, and other functions in many cell types.  Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor.  SMAD proteins mediate TGFB signaling.  SNON appears to maintain the repressed state of TGFB target genes in the absence of ligand and participates in negative feedback regulation of TGFB signaling. (from OMIM 190180 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                          
[19817] "TGF-beta 2, encoded by the TGFB2 gene, is a disulfide-linked homodimer belonging to the TGF-beta cytokine family that has suppressive effects on Interleukin-2-dependent T-cell growth. It may have an autocrine function in enhancing tumor growth and/or reducing immunosurveillance of tumor development. Two isoforms are produced by alternative splicing. TGF-beta 2 is expressed in a wide variety of mesenchymal tissues and in the ventral nervous system during human embryogenesis. (from OMIM 190220, Swiss-Prot P08112, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19818] "Transforming Growth Factor Beta 3, encoded by the TGFB3 gene, is a member of the TGF-beta cytokine family. It is expressed as a disulfide-linked homodimer in a wide variety of mesenchymal tissues during human embryogenesis. Transforming Growth Factor Beta 3 is involved in cell differentiation. (from OMIM, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19819] "The TBP gene at 6q27 encodes the TATA box-binding protein (TBP) that is the DNA-binding subunit of the RNA polymerase II transcription factor D (TFIID), a multisubunit complex essential for the expression of most, if not all, protein-encoding genes. The C-terminal domain of TBP is both necessary and sufficient for interaction with DNA and for assembly of the basal transcription apparatus in the initiation of mRNA synthesis and basal transcription. When bound to the TATA box, TBP interacts with the other subunits of TFIID such as TBP-associated factors (TAFs), with TFIIA and TFIIB, with the A form of RNA polymerase II CTD, and with positive and negative modulators of basal and activated transcription of class II genes. The N-terminus of TBP modulates the DNA-binding activity of the C-terminal of the protein. A complex neurologic and polyglutamate disease is due to (CAG)n repeat expansion in the TBP gene. (from OMIM 600075)"                            
[19820] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19821] "Apoptosis Regulation Genes encode Apoptosis Regulator proteins, which either promote or impede the initiation, progress, or rate of apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19822] "Telomerase is essential for maintenance of telomere length and genomic integrity in the long-term viability of high-renewal organ systems but is not required for establishment of cell lines, oncogenic transformation, or tumor formation in mice. Telomerase has both a protein and an RNA component. The TERC gene encodes the RNA component that acts as a template for the addition of telomeric repeat sequences. TERC is highly expressed in the germline and in tumor cell lines, in which there is high telomerase activity, and at lower levels in kidney, prostate, and liver, in which there is no detectable telomerase activity. The TERC gene is located at chromosome 3q21-q28 on the long arm of chromosome 3. Autosomal dominant dyskeratosis congenita is associated with mutations in the TERC gene. (from OMIM 602322 and NCI)"                                                                                                                                               
[19823] "Cytokines are a unique family of growth factors. Secreted primarily from leukocytes, cytokines stimulate both the humoral and cellular immune responses, as well as the activation of phagocytic cells. Cytokines that are secreted from lymphocytes are termed lymphokines, whereas those secreted by monocytes or macrophages are termed monokines. A large family of cytokines are produced by various cells of the body. Many of the lymphokines are also known as interleukins (ILs), since they are not only secreted by leukocytes but also able to affect the cellular responses of leukocytes. Specifically, interleukins are growth factors targeted to cells of hematopoietic origin. (http://indstate.edu/thcme/mwking/growth-factors)"                                                                                                                                                                                                                                                 
[19824] "ATL Derived Factor (thioredoxin) appears to be a cytokine as well as an oxidoreductase involved in redox reactions through reversible oxidation of its active center dithiol to a disulfide, catalyzing dithiol-disulfide exchange reactions.  It is ubiquitous, found in many organisms from plants and bacteria to mammals, and appears to have multiple substrates, including ribonuclease, choriogonadotropins, coagulation factors, glucocorticoid receptor, and insulin.  ATL Derived Factor augments expression of the IL2R, TAC (IL2R/P55).  (from OMIM 187700, Swiss-Prot P10599, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                
[19825] "Chemokines constitute a superfamily of small (8-10 kDa), inducible, secreted, pro-inflammatory cytokines that are involved in a variety of immune and inflammatory responses as well as in viral infection.  Chemokines act primarily as chemoattractants and activators of specific types of leukocytes.  Some members of this family were initially identified on the basis of their biological activities (e.g., IL-8, GRO), others were discovered using subtractive hybridization (e.g., RANTES) or signal sequence trap (e.g., PBSF/SDF-1)11 cloning strategies.  They attract and activate leukocytes and regulate diverse cellular systems and organs ranging from blood vessels to the central nervous system."                                                                                                                                                                                                                                                                            
[19826] "CXC-type chemokines are one of the two dual-cysteine classes of chemokines that contain paired cysteine residues, in their primary sequence, separated by a non-cysteine amino acid residue.  Chemokines of this class act as chemoattractants for neutrophils, but not for monocytes.  (from MSH98 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19827] "Encoded by human PPBP Gene (Alpha Chemokine CXC Family), secreted 128-aa 14-kDa (precursor) Pro-Platelet Basic Protein is a platelet-derived growth factor that is processed to PBP and CTAP-III. Upon platelet activation, PBP is proteolytically converted to Beta Thromboglobulin, a homotetramer released when platelets aggregate. Proteolytic removal of PPBP residues 1-9 produces active peptide CTAP-III/LA-PF4, which stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan, as well as formation and secretion of plasminogen activator. CTAP-III is also proteolytically converted to NAP2, a potent chemoattractant and activator of neutrophils. (NCI)"                                                                                                                                                                                                         
[19828] "Encoded by human PPBP Gene (Alpha Chemokine CXC Family), secreted 128-aa 14-kDa (precursor) Pro-Platelet Basic Protein is a platelet-derived growth factor that is processed to PBP and Connective-Tissue-Activating_Peptide-III. Proteolytic removal of PPBP residues 1-9 produces active peptide CTAP-III/LA-PF4, which stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan, as well as formation and secretion of plasminogen activator. Upon platelet activation, PBP is proteolytically converted to beta thromboglobulin, a homotetramer released when platelets aggregate; CTAP-III is proteolytically converted to NAP2, a potent chemoattractant and activator of neutrophils. (NCI)"                                                                                                                                                                              
[19829] "A 78 amino acid member of the CXC family of chemokines produced and secreted upon stimulation by interleukin 1 (IL1B) or tumor necrosis factor alpha.  Stimulates chemotactic migration of neutrophils, monocytes, lymphocytes, and fibroblasts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19830] "A CXC (or alpha) chemokine also known as MGSA, or melanoma growth-stimulating activity.  This family of chemokines also includes IL-8, platelet factor 4 (PF-4), beta-thromboglobulin (b-TG), IP-10, and ENA-78.  GRO is chemotactic for neutrophils."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19831] "A member of the alpha-chemokine family, IP10 is secreted from macrophages, endothelial cells, and keratinocytes in response to IFN-gamma and activates a G protein coupled receptor.  IP10 has homology to PFIV, BTG, CTAP-III, and peptides associated with cell proliferation, is a potent inhibitor of angiogenesis, inhibits bone marrow colony formation, has anti-tumor activity, is a chemoattractant for monocytes and T-cells, promotes T-cell adhesion to endothelial cells, and probably participates in chronic cell-mediated inflammatory reactions.  The IP10 gene is a RAS signaling target.  (from OMIM 147310 and NCI)"                                                                                                                                                                                                                                                                                                                                                            
[19832] "A member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types including monocytes, macrophages, T-lymphocytes, fibroblasts, endothelial cells, and keratinocytes. It functions as a chemoattractant, and is also a potent angiogenic factor. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19833] "Chemokines are small, mostly basic, related molecules that regulate trafficking of leukocytes through interactions with GPCRs.  In response to endotoxin, macrophages secrete MIP2, a protein with affinity for heparin and a potent chemotactic agent for polymorphonuclear leukocytes that causes a localized inflammatory reaction.  (from OMIM 139110 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19834] "Chemokines are small, mostly basic, related molecules that regulate trafficking of leukocytes through interactions with GPCRs.  There are two protein components of MIP1, alpha and beta.  MIP-2 beta may play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion.  MIP-2 beta expression studies indicate tissue-specific regulation as well as by specific agents, including IL-1, TNF, and lipopolysaccharide.  (from OMIM 139111, Swiss-Prot P19876, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19835] "Encoded by CC Cytokine Genes, Beta Chemokines are CC-type dual-cysteine chemokines with adjacent cysteine residues in their primary sequence that act as chemoattractants for lymphocytes, monocytes, eosinophils, and basophils, but not for neutrophils. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19836] "MIP-1 beta chemokine is chemotactic for neutrophils and monocytes, stimulates macrophages, and may play a role in regulating hematopoiesis.  MIP-1 beta is induced rapidly after T-cell activation with phytohemagglutinin, B-cell activation with Staphylococcus aureus, and monocyte activation with lipopolysaccharide.  It is predominantly synthesized by perforin-low memory CD8+ T-cells, a major non-cytotoxic population of CD8+ T-cells.  (from MSH98, OMIM 182284, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19837] "A CCR8-ligand, the inflammatory CXC cytokine I-309 is a small inducible chemotactic factor produced by activated T-lymphocytes, mast cells, and monocytes that appears to also promote angiogenesis.  (from OMIM 182281 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19838] "Chemokines, a family of small cytokines, attract leukocytes and possess various immunomodulating functions.  CC chemokines influence mononuclear cell types.  Human Macrophage Chemoattractant Protein-2 is a chemotactic factor for monocytes, lymphocytes, basophils and eosinophils.  This monomer or homodimer can bind heparin.  Its expression is induced by interferon gamma, mitogens, and IL-1. (from OMIM 602283, Swiss-Prot P80075, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19839] "A coordinated, single-cell function or a process involving or requiring whole cells or involving a major or a substantial portion of a cell or of the total machinery of a cell. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19840] "Macrophage Inflammatory Protein-1 is a monokine involved in the acute inflammatory recruitment and activation of polymorphonuclear leukocytes.  There are two protein components of MIP1, alpha and beta. MIP-1 alpha has been identified as an early G0/G1 switch gene in blood mononuclear cells.  RANTES, MIP-1 alpha, and MIP-1 beta are major HIV-suppressive factors produced by CD8-positive T-cells.  (from OMIM 182283 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19841] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19842] "A member of the interleukin-8 superfamily of cytokines, RANTES is released from platelets and activated T-cells, and is a selective chemoattractant for eosinophils, monocytes, and memory T-lymphocytes.  RANTES expression is increased more than ten-fold in peripheral lymphocytes following mitogenic or antigenic stimulation.  RANTES is one of the natural ligands for the chemokine receptor CCR5.  Chemokines RANTES, MIP-1 alpha, and MIP-1 beta are major HIV-suppressive factors produced by CD8-positive T-cells.  (from OMIM 187011 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19843] "Secondary Lymphoid Tissue Chemokine is an endothelial CC (beta) subfamily chemokine expressed preferentially in lymph node tissue.  Unlike other CC chemokines, SLC is specifically chemotactic for Th1 lymphocytes, and for dendritic cells.  The ability of SLC to chemoattract both Th1 lymphocytes and dendritic cells formed the rationale to evaluate this chemokine in cancer immunotherapy.  (from OMIM 602737 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19844] "Chemoattractant cytokines (chemokines) are important for leukocyte recruitment to inflammatory lesions.  The eotaxin chemokine is a potent chemoattractant for eosinophil migration and accumulation.  A high-affinity eotaxin receptor CCR3, involved in allergic inflammation, is highly expressed on eosinophils, basophils, and TH2 lymphocytes.  CCR3, a GPCR, induces a calcium response in eosinophils, and also binds RANTES and monocyte chemotactic protein-3.  Eotaxin also interacts with CCR2 and CCR5 receptors and thus can affect monocyte responses.  In monocytes, eotaxin modifies responsiveness to the CCR2 ligand MCP1, as well as to RANTES and MIP1-beta, which bind to CCR5; eotaxin is a CCR5 agonist and a CCR2 antagonist.  Eotaxin also induces endothelial cell migration and angiogenesis.  (from OMIM 601156 and NCI)"                                                                                                                                              
[19845] "Chemokines (chemotactic cytokines) other than those in the C, CC, or CXC classes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19846] "Smaller fragment formed when C5 convertase splits C5 into C5a and C5b. C5a is a 74-amino acid peptide that includes a carboxy-terminal arginine crucial for its spasmogenic activity and a carbohydrate moiety. Initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex.  C5a is the most potent anaphylatoxin, mediating immediate hypersensitivity. C5a is also chemotactic for neutrophils and monocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19847] "The last family member of chemokines is the CX3C (delta) chemokines. As the acronym suggests, there are three amino acids between the N-terminal cysteine residues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19848] "Fractalkine, encoded by the cytokine D1 gene, is the first member of a fourth branch of the chemokine superfamily. Unlike other known chemokines, fractalkine is a type 1 membrane protein with a signal peptide, a chemokine domain, a stalk region containing 17 degenerate mucin-like repeats, a transmembrane segment and a cytoplasmic domain. The extracellular domain of fractalkine is released into the supernatants of transfected cells as a 95 kDa glycoprotein, possibly by proteolysis at the dibasic cleavage site proximal to the membrane, to generate soluble fractalkine. mRNA expression is most abundant in the brain and heart, but is also present at lower levels in other tissues tested except peripheral blood where most chemokines are highly expressed. The expression of fractalkine in microglia, endothelial and fibroblastic cells is upregulated by inflammatory signals."                                                                                       
[19849] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19850] "Molecular nanotechnology is the name given to a specific sort of manufacturing technology. As its name implies, molecular nanotechnology will be achieved when we are able to build things from the atom up, and we will be able to rearrange matter with atomic precision. This technology does not yet exist; but once it does, we should have a thorough and inexpensive system for controlling of the structure of matter."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19851] "Flt3 ligand is a novel hematopoietic growth factor ligand for the FLT3 tyrosine kinase receptor.  This growth factor stimulates the proliferation of hematopoietic progenitor cells.  FLT3 (FLK2) is a tyrosine kinase receptor structurally related to CSF1 and KIT.  (from OMIM 600007 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19852] "(in-ter-FEER-on) A biological response modifier (a substance that can improve the body's natural response to infection and disease). Interferons interfere with the division of cancer cells and can slow tumor growth. There are several types of interferons, including interferon-alpha, -beta, and -gamma. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19853] "A class of interferon (leukocyte interferon) produced predominantly by B lymphocytes.  Located in a cluster on 9p22 there are at least 13 functional genes and 1 pseudogene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19854] "A class of interferon elaborated by fibroblasts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19855] "Interferon gamma (IFNg) is produced by activated T cells and is an important immunoregulatory molecule, particularly in allergic diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19856] "(in-ter-LOO-kins) Biological response modifiers (substances that can improve the body's natural response to infection and disease) that help the immune system fight infection and cancer. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19857] "A general term for soluble mediators of immune responses that are not antibodies or complement components and that are released by sensitized lymphocytes on contact with antigen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19858] "Oncostatin M, a glycoprotein with an approximate molecular weight of 28,000, was originally isolated from a conditioned medium of human leukemia cells that had been induced to differentiate into macrophage-like cells by treatment with phorbol 12-myristate 13-acetate. OSM has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts; hence, its name. It is a member of the IL-6 family of cytokines that is primarily known for its effects on cell growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19859] "(TOO-mer ne-KRO-sis) A type of biological response modifier that can improve the body's natural response to disease. (NCI-GLOSS)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19860] "The protein that coordinates transcription initiation by RNA polymerase II is transcription factor IID (TFIID). TFIID binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and TBP-associated factors (TAFs). TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. The TAF2 gene at 8q24.12 encodes a 150-kD protein and one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. (LocusLink 6873 and NCI)"                          
[19861] "The highly conserved RNA polymerase II transcription factor TFIID comprises the TATA box-binding protein and a set of TBP-associated factors (TAFs). TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors. The TAF3 gene encodes a 140-kD protein that forms complexes with TBP and TAF13 as well as with SF3B3, TAFII140 and GCN5. TAF3 interacts with TAF10 through their HFDs. The TAF3 gene is located at chromosome 10p15.1 on the short arm of chromosome 10. (from OMIM 606576 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19862] "The TAF4 gene at chromosome 20q13.33 encodes a 135-kD protein and one of the larger subunits of TFIID that potentiates transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors.  In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions.  TAF4 is sufficient to recruit a polymerase complex and activate basal transcription mediated by CREB.  Increased levels of TAF4 facilitate the induction of a large number of neuronal genes.  Interference of CREB-dependent transcription by the binding of TAF4 with expanded polyQ stretches is involved in the pathogenetic mechanisms underlying neurodegeneration.  At least 8 neurodegenerative disorders, which include Huntington disease and several forms of spinocerebellar ataxia, are due to expansions of CAG repeats encoding polyglutamine (polyQ) stretches.  (NCI)"        
[19863] "Processes that promote, sustain, and preserve cell viability. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19864] "The multisubunit TFIID transcription factor is the DNA-binding component of the transcriptional machinery of RNA polymerase II. TFIID is composed of TATA box-binding protein (TBP) and TBP-associated factors (TAFs). The TAF5 gene encodes a 100-kD protein that is the third largest human TFIID subunit. TAF5 interacts strongly with the histone H4-related TAF6 and the histone H3-related TAF9, as well as a stable complex comprised of both TAF6 and TAF9. Weaker interactions of TAF5 with TBP, TAF1, TAF11, and TAF12, but not TAF7, also occur. TAF5 may stabilize interactions of TAFs, especially the histone-like TAFs, in TFIID for a possible core promoter-specific function. The TAF5 gene is located at chromosome 10q24-q25.2 on the long arm of chromosome 10. (from OMIM 601787, PMID 9045704)"                                                                                                                                                                              
[19865] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19866] "Encoded by human IL2 Gene, Interleukin-2 is a secreted cytokine important for proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2 expression in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling expression of a single gene. Targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role in the immune response to antigenic stimuli. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                         
[19867] "(in-ter-LOO-kin) IL-4. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease) that enhances the immune system's ability to fight tumor cells. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19868] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19869] "Encoded by human IL7 Gene, Interleukin-7 is an important cytokine for B and T cell development. This cytokine and HGF form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is a cofactor for V(D)J rearrangement of T cell receptor beta (TCRB) during early T cell development. IL7 can be produced locally by intestinal epithelial and epithelial goblet cells, and may be a regulatory factor for intestinal mucosal lymphocytes. Studies in mice suggest that IL7 plays an essential role in lymphoid cell survival. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                         
[19870] "produced by T cells and macrophages; acts as a growth factor for some T cell populations in vitro."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19871] "Expressed primarily in monocytes and less in lymphocytes by human IL10 Gene, Interleukin-10 is a cytokine with pleiotropic effects in immunoregulation and inflammation. It down-regulates expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Studies in mice suggest that this cytokine as an essential immunoregulator in the intestinal tract. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                        
[19872] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19873] "Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                 
[19874] "Interleukin-13, encoded by the IL13 gene, is an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. Interleukin-13 is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. (From LocusLink)"                                                                                                                                                                                                                                                 
[19875] "Interleukin-14, encoded by the IL14 gene, is a cytokine that induces B-cell proliferation, inhibits immunoglobulin secretion, and selectively expands certain B-cell subpopulations. (from The On-line Medical Dictionary http://cancerweb.ncl.ac.uk/omd/)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19876] "Interleukin-15, encoded by the IL15 gene, is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukin 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Three alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. (From LocusLink)"                                                                                                                                                                                                                                                      
[19877] "Interleukin-16, encoded by the IL16 gene, is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. As a ligand for CD4, the signaling process of this cytokine is mediated by CD4. It stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils as well as induces T-lymphocyte expression of interleukin 2 receptor. The product of this gene undergoes proteolytic processing, which yields two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is involved in the proteolytic processing of this protein. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. (From LocusLink, Swiss-Prot and NCI)"                                                                                                           
[19878] "Interleukin 17 is a homodimer expressed in stimulated, but not resting, cytotoxic T-cells that induces stromal cells to produce pro-inflammatory and hematopoietic cytokines.  IL17 enhances expression of IL6, IL8, and ICAM-1 in fibroblasts and appears to induce osteoclastogenesis and ODF, a membrane-associated protein essential to osteoclast differentiation.  IL17 has sequence similarity to the herpesvirus saimiri immediate early gene 13 protein.  (from OMIM 603149 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19879] "Cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK cells and CTLs, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19880] "IL-1-alpha. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease). IL-1-alpha stimulates the growth and action of immune system cells that fight disease. IL-1-alpha is normally produced by the body, but it can also be made in the laboratory.  Also called IL-1-alfa."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19881] "Interleukin-1 (endogenous pyrogen), produced primarily by monocytes, is an important pro-inflammatory cytokine that mediates the acute phase host response.  The biologic activities of IL1 are properties of a protein derived from a larger precursor.  Inflammation causes induction of COX2, leading to release of prostanoids, which sensitize peripheral nociceptor terminals and produce local pain hypersensitivity.  Inflammation also generates sensitivity in neighboring tissue, muscle and joint pain, fever, lethargy, and anorexia.  COX2 induction in regions of the CNS is mediated by IL1B.  Interleukin-1-beta also stimulates bone resorption.  IL1RN is a competitive inhibitor of IL1B.  Mature IL1-beta levels are a sensitive and specific indicator of caspase-1 activation.  (from OMIM 147720 and NCI)"                                                                                                                                                                  
[19882] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19883] "Leukemia Inhibitory Factor (LIF) affects many systems, including hematopoietic, embryonic, bone, hepatic, neuronal, and fat tissues. LIF induces MHC class I HLA-G expression by cytotrophoblasts, which is essential in implantation and may facilitate immune tolerance of the conceptus at the maternal-fetal interface. LIF, secreted by ureteric bud cells, converts kidney mesenchyme to epithelia, which then forms nephrons. LIF and BMP2 cytokines signal through different receptors and transcription factors (STATs and SMADs) and act in synergy on neural progenitors to induce astrocytes. Transcriptional co-activator p300 interacts with STAT3 in a cytokine-independent manner and with SMAD1 in a cytokine-dependent manner. Formation of a STAT3/SMAD1 complex, bridged by p300, mediates cooperative signaling of LIF and BMP2 and induction of astrocytes from neuronal progenitors. (from OMIM and NCI)"                                                                    
[19884] "A glycoprotein of 50 kDa secreted by activated natural killer lymphocytes. Leukoregulin shows tumor growth inhibitory activity and enhances membrane permeability and the uptake of cytotoxic drugs by tumors cells without affecting these processes in normal cells.  (from Cytokines Online Pathfinder Encyclopaedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19885] "The TAF6 gene at 7q22.1 encodes a protein that interacts with TBP, TAF1, TAF9, TAF12, TFIIE-alpha, and TFIIF-alpha. TAF6 binds weakly to TBP and tightly to TAF1, the largest subunit of TFIID. In the presence of TAF6, TBP, and TAF1, a stable ternary complex forms. TAF6-delta is a specialized isoform of TAF6 with a deletion in its histone fold motif, which is involved in dimerization contacts with TAF9. Unlike TAF6, TAF6-delta forms a TFIID-like complex lacking TAF9. Several distinct apoptotic stimuli induce the expression and caspase-dependent cleavage of TAF6-delta. Elevated expression of TAF6-delta triggers apoptotic cell death and selectively alters cellular transcription, including the induction of the target genes GADD45 and p21 in a signaling pathway that couples apoptotic signals to a reprogramming of RNA polymerase II transcription. (from OMIM 602955 and NCI)"                                                                                     
[19886] "TFIID is composed of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs). The TFIID complex binds to the TATA box in class II promoters and then recruits other factors as well as RNA polymerase II. The TAF7 gene encodes a 55-kD subunit of the TFIID protein complex which is required for transcription by promoters targeted by RNA polymerase II. TAF7 interacts with TAF1, the largest subunit of TFIID, and with multiple transcription activators, including Sp1, YY1, USF, CTF, and adenoviral E1A. The TAF7 mRNA is expressed in all tissues examined. The intronless TAF7 gene is located at chromosome 5q31 on the short arm of chromosome 5. (from OMIM 600573 and NCI)"                                                                                                                                                                                                                                                                                       
[19887] "A cell surface marker on T-cells.  A member of the TNF family.  It regulates B cell function by engaging CD40 on the B cell surface."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19888] "FAS ligand is a TNF family, type II transmembrane protein expressed on many cell types and secreted from T-cells upon TCR ligation by MHC/peptide complexes residing on antigen presenting cells.  FAS ligand triggers cell death by binding to the cell surface receptor FAS, another transmembrane protein member of the TNF receptor family.  FAS ligand is expressed in activated splenocytes and thymocytes, consistent with its involvement in T-cell-mediated cytotoxicity, and in the liver, lung, ovary, and heart, where its function is unclear.  (from OMIM 134638 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                            
[19889] "Lymphotoxin (LT) is a cytokine that orchestrates lymphoid neogenesis and formation of germinal center reactions. LT exists as a membrane heterotrimer of alpha and beta subunits and is secreted as a homotrimer, LTalpha3.  Also called TUMOR NECROSIS FACTOR BETA. from J Immunol 1999;162:1333-1338"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19890] "X chromosome has a predominant role in pre-meiotic stages of mammalian spermatogenesis. The TAF7L gene encodes a 50-kD protein that is a TATA box binding protein-associated factor (TAF) with testis-specific expression in only male germ cells. The TAF7L gene is located at chromosome Xq22.1 on the long arm of chromosome X. (from OMIM 300314)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19891] "OX40 ligand is a type II membrane protein and member of the tumor necrosis factor family.  OX40L interaction with its receptor OX40 may induce T-cell activation.  Treatment with an antibody against OX40 ligand (OX40L) prevents rheumatoid arthritis in a murine model of the disease.  (from Eur J Immunol 2000. 30:2815, OMIM 603594, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19892] "Tumor Necrosis Factor Ligand Superfamily Member 10, encoded by the TNFSF10 Gene, is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of cells. It preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. (From LocusLink, OMIM and NCI)"                                  
[19893] "No info. in OMIM, PubMed or HUGO as of 12/09/2003."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19894] "RAEB: Use for basic or therapeutic studies. Also code SIC 6 (immunology)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19895] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19896] "RNA polymerase II transcription factor IID is a complex of the TATA binding protein (TBP) and a variety of TBP-associated factors (TAFs). The TAFs are required for activated rather than basal transcription and serve to mediate signals between various activators and the basal transcriptional machinery. The TAF9 gene encodes a 32-kD protein that interacts with the N-terminal domain of p53 at sites identical to those bound by MDM2, the major cellular negative regulator of p53 activity. p53-activated transcription activity is regulated by these 2 proteins competing for the same region of the p53 protein. TAF9 also interacts with GTF2B and the viral transcriptional transactivator VP16. The TAF9 gene is located at chromosome 5q11.2-q13.1 on the long arm of chromosome 5. (from OMIM 600822 and NCI)"                                                                                                                                                                  
[19897] "Initiation of transcription by RNA polymerase II requires the ordered assembly of basal transcription factors including TFIIA, TFIIB, TATA-binding protein (TBP), TFIIE, TFIIF, TFIIG/TFIIJ, and TFIIH/BTF2 into the TFIID complex, which also includes a number of TBP-associated factors (TAFs). Different activators may interact with specific TAFs to allow the assembly of functionally distinct TFIID complexes that can control transcription of different genes, such as the estrogen receptor, which bind directly to TBP, TFIIB, or both. The TAF10 gene encodes a 30-kD protein that is involved in transcription complex assembly and regulation. TAF10 is necessary for transcriptional activation by the estrogen receptor. The TAF10 gene is located at chromosome 11p15.3 on the short arm of chromosome 11. (from OMIM 600475 and NCI)"                                                                                                                                           
[19898] "Control of transcription by RNA polymerase involves the basal transcription machinery, a collection of proteins which include TFIIB, TFIIE, TFIIF, TATA-box binding protein (TBP), TFIIA and TAF1. These, with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TBP-associated factors (TAFs) encoded by these TBP-Associated Factor Genes. Different TAFs may mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. (from OMIM 600772 and NCI)"                                      
[19899] "Initiation of transcription by RNA polymerase II requires the ordered assembly of basal transcription factors including TFIIA, TFIIB, TATA-binding protein (TBP), TFIIE, TFIIF, TFIIG/TFIIJ, and TFIIH/BTF2 into the TFIID complex, which also includes a number of TBP-associated factors (TAFs). Different activators may interact with specific TAFs to allow the assembly of functionally distinct TFIID complexes that can control transcription of different genes. The TAF11 gene encodes a 28-kD protein that is a component of the TFIID complex involved in transcription complex assembly and regulation. Different domains of TAF11 interact with TAF13 and TBP. The TAF11/TAF13 heterodimer form a novel histone-like pair in the TFIID complex and they define a novel family of atypical histone fold sequences. The TAF11 gene is located at chromosome 6p21.31 on the short arm of chromosome 6. (from OMIM 600772 and NCI)"                                                       
[19900] "Control of transcription by RNA polymerase II involves the basal transcription machinery, a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. The TAF12 gene at 1p35.2 encodes a protein that interacts directly with TBP as well as with TAF11 and TAF10. (from OMIM 600773, LocusLink 6883 and NCI)"                                 
[19901] "TAF proteins are tightly associated with TBP in the TFIID complex. Different TAFs mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. The TAF13 gene at 1p13.1 encodes a protein that interacts through distinct domains with TBP but interacts more strongly with TAF11 and TAF10. The TAF11/TAF13 heterodimer form a novel histone-like pair in the TFIID complex and they define a novel family of atypical histone fold sequences. (from OMIM 600774, LocusLink 6884 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19902] "Human transcription initiation factor TFIID is composed of the TATA-binding protein (TBP) and at least 13 TBP-associated factors (TAFs) that collectively or individually are involved in activator-dependent transcription. Initiation of transcription by RNA polymerase II requires the ordered assembly of basal transcription factors including TFIIA, TFIIB, TATA-binding protein (TBP), TFIIE, TFIIF, TFIIG/TFIIJ, and TFIIH/BTF2 into the TFIID complex. Different activators may interact with specific TAFs to allow the assembly of functionally distinct TFIID complexes that can control transcription of different genes. (NCI)"                                                                                                                                                                                                                                                                                                                                                      
[19903] "The three subunits of the TFIIA complex (alpha, bet, and gamma) are encoded by the GTF2A1 and GTF2A2 genes. TFIIA has multiple roles in transcription initiation by RNA polymerase II. First, the association of TFIIA and TBP stabilizes the TBP-TATA element interaction. In so doing, TFIIA also stimulates transcription by displacing TBP-associated repressors and counteracts the ability to inhibit TBP binding to DNA. Second, TFIIA serves as a cofactor for the activators and coactivators. Third, TFIIA is required for the isomerization and extension of TFIID-promoter contacts and for stabilizing interactions between TFIID and initiator sequences. (from PMID 10364255)"                                                                                                                                                                                                                                                                                                       
[19904] "An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages."                                                                                                                                                                                                                                                                                                                                                                                                    
[19905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19906] "A single-chain polypeptide of approximately 15-16 kDa which has been isolated from a variety of cells. It has a 55% amino acid residue identity to acidic fibroblast growth factor and has potent heparin-binding activity. However, in contrast to the acidic fibroblast growth factor, heparin does not potentiate the biological activities of bFGF. The growth factor is an extremely potent inducer of DNA synthesis in a variety of normal diploid mammalian cell types from mesoderm and neuroectoderm lineages and promotes cellular differentiation in vitro. (MSH99)"                                                                                                                                                                                                                                                                                                                                                                                                                     
[19907] "A modifier of endothelial cell migration and proliferation, Fibroblast Growth Factor 1 may be important in neovascularization.  Acidic Fibroblast Growth Factor and alpha-ECGF are derived from FGF1 by posttranslational processing.  FGF1 causes the foregut endoderm to develop into the liver.  The hepatogenic response is restricted to endoderm tissue, which selectively co-expresses FGF receptors 1 and 4.  Different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis.  FGF1 binding to FGFR2 is accompanied by binding of a heparin decasaccharide.  (from OMIM 131220 and NCI)"                                                                                                                                                                                                                                                                                                                                                      
[19908] "Fibroblast Growth Factor 3 is a member of the FGF family.  Fibroblast growth factors have been associated with mesoderm induction and FGF3 has a distinct pattern of expression throughout development in vertebrates.  FGF3 constitutes a signal for induction of the otic vesicle, the primordium of the inner ear.  (from OMIM 164950 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19909] "Fibroblast Growth Factor 4 is a heparin-binding growth factor with significant homology to human fibroblast growth factors that appears to function in limb development in conjunction with the SHH pathway.  (from OMIM 164980 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19910] "General transcription factors (GTFs), including TATA box-binding protein (TBP), are necessary for the initiation of transcription of eukaryotic genes. The TBPL1 gene encodes 24-kD TBP-like protein that is a general transcription factor essential for spermiogenesis and required for heterochromatic chromocenter formation in haploid round spermatids. While TBP is ubiquitously expressed, TBPL1 expression is strictly developmentally regulated. TBPL1 mRNAs are expressed in various human tissues ubiquitously but highest expression occurs in testis. TBP and TLF function differentially to control transcription of different sets of genes. TBPL1 interacts with both GTF2A and GTF2B. However, TBPL1 does not bind to the TATA-box nor direct transcription initiation in vitro. The TBPL1 gene is located at chromosome 6q22.1-q22.3 at the long arm of chromosome 6. (from OMIM 605521, PMID 11861477, PMID 10082669)"                                                          
[19911] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19912] "Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. The APEXL2 gene at chromosome Xp11.22 encodes Apurinic/Apyrimidinic Endonuclease 2, a protein that has a weak class II AP endonuclease activity. Most of this protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). (From LocusLink 27301)"                                                                                                                                                                                                                 
[19913] "The ERCC1 gene at 19q13.2-q13.3 encodes DNA excision repair protein ERCC-1. Its C-terminal is essential for enzymatic activity of a structure-specific endonuclease and the central region is involved in protein-protein interactions. The ERCC1 gene is involved in UV cross-link repair and nucleotide excision repair (NER). With p53 monitoring DNA damage, either XPA loads and possibly orients an incision complex, containing ERCC1 and other repair factors, to the site of DNA damage or XPA, ERCC1, and ERCC4 proteins form a ternary complex that participates in both damage recognition and incision activities. In the absence of DNA damage, the complex moved freely through the nucleus. Ultraviolet light-induced DNA damage causes a transient immobilization of ERCC1/XPF to engage the complex in a single repair event. Afterwards, the complex regains mobility. (From OMIM 126380 and NCI)"                                                                               
[19914] "Human ERCC2 Gene (RAD3/XPD Family) encodes 760-aa 87-kDa nuclear DNA Excision Repair Protein ERCC2, an ATP-dependent 5 prime-3 prime DNA helicase and one of six integral subunits of the basal transcription factor BTF2/TFIIH complex. Recruited by transcription preinitiation or DNA damage recognition complexes, ERCC2 is involved in RNA polymerase II transcription, transcription-coupled nucleotide excision DNA repair, and cell cycle regulation. ERCC2/MAT1 anchors CAK complex to the TFIIH complex. CAK inhibits ERCC2 helicase activity; overcome by binding TFIIH subunit p44, which stimulates helicase activity. ERCC2 defects result in XPD, XPD/CS, TTD, and COFS Syndrome. (NCI)"                                                                                                                                                                                                                                                                                             
[19915] "The ERCC3 gene encodes DNA Excision Repair Protein ERCC-3, an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. This protein is also the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. (from LocusLink 2071 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19916] "The ERCC5 gene encodes XPG-Complementing Protein, which is involved in transcription-coupled repair of UV-induced DNA damage. The encoded protein is a single-strand specific DNA endonuclease that nicks damaged DNA 3-prime to the lesion in nucleotide excision repair as a result of the combined action of the XPB helicase and XPD helicase following sequential assembly of repair proteins at the DNA damage site. In addition, it associates with CSA, CSB, or both proteins at the transcriptional pause sites to facilitate the resumption of transcript elongation without aborting the associated nascent transcript by pushing the stalled RNA polymerase II either forward or backward not only from the damaged site but also from some natural transcription pause sites. Mutational inactivation of XPG causes Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. (from OMIM 133530, LocusLink 2073 and NCI)"                  
[19917] "The ERCC4 gene at 16p13.3-p13.11 encodes DNA Excision Repair Protein ERCC-4, a DNA repair protein. Nucleotide excision repair (NER) involves incision of a DNA strand on each side of a lesion. The two incisions made during NER are catalyzed by separate DNA endonucleases. A tight protein complex formed between ERCC4 and ERCC1 acts as a structure-specific endonuclease for the 5-prime incision during repair. Without DNA damage, this complex moves freely through the nucleus. Ultraviolet light-induced DNA damage causes a transient immobilization of ERCC4/ERCC1 due to engagement of the complex in a single repair event after assembly of individual nucleotide excision repair factors at sites of DNA damage in a distributive fashion. Causative mutations in the ERCC4 gene and strongly reduced levels of encoded protein can be identified in patients with xeroderma pigmentosum type F. (From OMIM and NCI)"                                                             
[19918] "The TREX1 gene at 3p21.3-p21.2 is expressed in all tissues tested and it uses two different open reading frames (ORF). Both ORFs are subject to alternative splicing, resulting in 6 transcript variants. The upstream ORF encodes proteins which interact with ATR (a checkpoint kinase) and localize to intranuclear foci following DNA damage. The TREX1 protein is phosphorylated by ATR, regulates ATR expression, and is an essential component of the DNA damage checkpoint pathway. TREX1 and ATR are mutually dependent partners in cell cycle checkpoint signaling pathways. The downstream ORF encodes isozymes that contain 3-prime-to-5-prime exonuclease activity and the excision of nucleotides from DNA 3-prime termini are required by DNA replication, repair, and recombination. They remove mismatched, modified, fragmented, and normal nucleotides to generate the appropriate 3-prime termini for subsequent steps in the DNA metabolic pathways. (NCI)"                    
[19919] "The ATR gene at 3q22-q24 encodes Ataxia Telangiectasia and Rad3 Related Protein (ATR), a member of the PIK (phosphatidylinositol kinase)-related kinase family that are high molecular weight kinases involved in cell cycle progression, DNA recombination, and the detection of DNA damage. ATR is essential for the viability of human somatic cells. ATR and ATRIP (ATR-interacting protein) are mutually dependent partners in cell cycle checkpoint signaling pathways - ATR phosphorylates ATRIP that regulates ATR expression and is an essential component of the DNA damage checkpoint pathway. ATR phosphorylates checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. ATR may be particularly essential in the early embryo to sense incomplete DNA replication and prevent mitotic catastrophe. (From OMIM 601215 and NCI)"                                                                                                         
[19920] "The TREX2 gene at Xq28 encodes small proteins that are independent 3-prime excision enzymes. In addition, one splice variant uses a different open reading frame and encodes a protein structurally unrelated to the other isoforms. This protein interacts with ubiquitin C-terminal hydrolase 37, which may edit polyubiquitin chains on ubiquitinated substrates. The other TREX2 proteins have 3' exonuclease activity, prefer mismatched 3-prime termini and may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity. The excision of nucleotides from DNA 3-prime termini are required to generate the appropriate 3-prime termini for subsequent steps in the DNA metabolic pathways. The TREX2 gene is ubiquitously expressed."                                                                                                                                                                                                                          
[19921] "This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19922] "This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19923] "The TINF2 gene at chromosome 14q11.2 encodes TERF1 (TRF1)-Interacting Nuclear Factor 2 (TINF2), a 50-kD telomere-associated protein. TINF2 regulates telomere length and prevents excessive telomere elongation. TINF2 binds telomeric DNA-binding-protein (TRF1) and is an essential mediator of TRF1 function. Three isoforms, 1, 2, and 3, may be produced by alternative splicing. TINF2 is detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. (From Swiss_Prot, LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19924] "The LIG4 gene at chromosome 13q33-q34 encodes DNA ligase IV (LIG4), a 96-kD protein that belongs to the ATP-dependent DNA ligase family. LIG4 efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is the activity responsible for the ligation step in nonhomologous DNA end joining and in V(D)J recombination. Defects in LIG4 are the cause of LIG4 syndrome. (OMIM 601837)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19925] "Ku Subunit Genes encode tightly-associated 70-kDa Ku70 Protein and 80-kDa Ku80 Protein subunits of heterodimeric DNA-binding Ku Protein, a DNA damage repair complex that, with the 470-kDa catalytic DNA-PKcs subunit forms DNA-dependent protein kinase, binds and repairs double-stranded DNA breaks, facilitates repair by nonhomologous end-joining, and is involved in V(D)J recombination. Ku also binds to DNA ends with a telomere binding protein and mediates telomere capping to prevent fusion of chromosome ends and genetic instability. KU70 and KU80 form a dyad-symmetrical ring molecule that encircles duplex DNA. Ku is identical to DNA helicase II, an ATP-dependent DNA unwinding enzyme. (NCI)"                                                                                                                                                                                                                                                                            
[19926] "Widely expressed as 3.9-, 4.5-, 6.0-, and 7.0-kb transcripts (highest in heart, ovary; lowest in brain, testis) single-copy 7-exon 18-kb human XAF1 Gene (IAP Family) encodes 317-aa 37-kDa XIAP-Associated Factor 1, containing 3 Cys-rich BIR domains (bind to and inhibit caspases), 7 zinc fingers, and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase activity. Associated with nuclear redistribution of XIAP, cytoplasmic XAF1 appears to antagonize nuclear XIAP inhibition of CASP3 activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[19927] "The G22P1 gene at 22q11-q13 encodes Ku70, a 70-kD subunit of the Ku antigen in DNA repair or transposition. The Ku antigen is a complex that binds to the ends of double-stranded DNA in a cell cycle-dependent manner and Ku70 mediates binding of the Ku complex to DNA. Though a major threat to living cells, eukaryotes can process double-strand DNA breaks (DSBs) by homologous recombination (HR) or nonhomologous end joining (NHEJ). Ku70 acts as a switch between these 2 DSB repair pathways. When present, Ku70 destines DSBs for NHEJ by binding to DNA ends and attracting other factors for NHEJ, including MRE11. When absent, it allows participation of DNA ends and MRE11 in the meiotic HR pathway. Ku70 deficiency facilitates neoplastic growth and the G22P1 gene is important in tumor suppression. The autoantibody has been found in patients with autoimmune thyroid disease (Graves disease) as well as in those with lupus. (from OMIM 152690 and NCI)"               
[19928] "A drainage tube. A surgeon implants or creates a shunt to divert blood or other fluid from one part of the body to another part. For example, a surgeon may implant a tube to drain cerebrospinal fluid from the brain to the abdomen. Or a surgeon may divert normal blood flow by joining two blood vessels together."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19929] "Human HMG Family Genes encode ubiquitous non-histone HMG chromatin proteins originally named according to PAGE electrophoretic mobility, shared physical properties, and association with chromatin. Canonical HMG proteins are subdivided into 3 superfamilies with characteristic functional sequence motifs: HMGB (formerly HMG-1/-2), HMGN (formerly HMG-14/-17), and HMGA (formerly HMG-I/Y/C). DNA-binding HMG proteins appear to have roles in matrix stabilization, ssDNA protection, replication, and transcription that influence cell growth, proliferation, differentiation, and death. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                          
[19930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19932] "Human HMGA Family Genes encode HMGA proteins that participate in many nuclear processes ranging from chromosome and chromatin mechanics to transcription factors that regulate gene expression. Hence, they influence diverse biological processes including cell growth, proliferation, differentiation and death. HMGA proteins contain three AT-hooks that bind to minor groove AT-rich stretches. HMGA proto-oncogenes promote tumor progression and metastasis when overexpressed. High constitutive HMGA expression is consistently observed in cancers, with increasing concentrations being correlated with increasing malignancy. (NCI)"                                                                                                                                                                                                                                                                                                                                                   
[19933] "Human HMGB Family Genes encode abundant DNA-binding and bending HMG-Box Family proteins (with structure, rather than sequence, specificity) that play an architectural role in nucleoprotein assembly. They have two homologous DNA-binding HMG-box domains connected by a short basic linker to an acidic C-terminus that differs in length. Tail length may be the dominant factor mediating property differences among HMGB proteins and determines DNA-binding properties of the HMG boxes. The tail is essential for DNA-binding. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[19934] "Human HMGN Family Genes encode nuclear HMGN proteins that bind to nucleosomes, change chromatin architecture, and enhance transcription or replication. They typically contain a Nucleosome Binding Domain that anchors these proteins to nucleosome cores to facilitate changes in higher order chromatin structure. HMGN chromatin association is dynamic and regulated by posttranslational modification; related to cell cycle and transcriptional events. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19935] "The HMGA1 gene at 6p21 encodes members of the HMGA1 family (HMGA1a, HMGA1b, HMGA1c) of nonhistone proteins that function as gene transcriptional regulatory proteins. HMGA1 proteins bind specifically to the minor groove of AT-rich sequences of DNA and no posttranslational modifications are necessary for specific DNA binding. The HMGA1 gene is a potential oncogene and c-MYC upregulated HMGA1 expression is involved in neoplastic transformation in Burkitt's lymphoma and pathogenesis of breast cancer. Alternative splicing of a single primary transcript gives rise to distinct but structurally highly similar mRNAs and the isoform proteins. HMGA1a plays an essential role in the assembly and function of a virus-induced enhanceosome in activated transcription of the beta-interferon gene and HMGA1c is important for retinoid dependent transcriptional activity of retinoic acid receptors. (NCI)"                                                                      
[19936] "The HMGA2 gene encodes an 11-kD protein that functions as an architectural factor and is an essential component of the enhancesome. The HMGA2 protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. The HMGA2 gene is expressed predominantly during embryogenesis and the HMGA2 protein is regulated by cell cycle-dependent phosphorylation which alters DNA binding affinity. The HMGA2 gene is involved in mesenchymal differentiation, adipogenesis and diet-induced obesity. The HMGA2 gene is rearranged in benign tumors of 8 different types (lipoma, pleomorphic salivary adenoma, and uterine leiomyoma) by translocation that leads to either reexpression of HMGA2 or formation of particular fusion genes. Inactivation of the HMGA2 gene by insertional mutation causes pygmy in mice. The HMGA2 gene is located at chromosome 12q15 on the long arm of chromosome 12."                                                                
[19937] "The HMGB1 gene at 13q12 encodes HMGB1, which is a very abundant and conserved 25-kD protein that plays a central role in the stabilization and/or assembly of several nucleoprotein multifunctional complexes through protein-protein interactions. HMGB1 is essential in a variety of DNA-related biological processes, e.g., V(D)J recombination, the initiation of transcription, and DNA repair. HMGB1 binds DNA without sequence specificity, but has a high affinity for bent or distorted DNA, and bend linear DNA. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. HMGB1 is structured into two DNA-binding HMG-box domains (A and B) plus a long highly acidic C-terminal domain. The individual A and B boxes exhibit many of the structure-specific properties of the whole protein and the acidic tail modulates the affinity of the tandem HMG boxes in HMGB1 for a variety of DNA targets. (PMID 11497996, PMID 11748221)"         
[19938] "The HMGG2 Gene at 4q31 encodes HMGB2, which is a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein is also involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. (From LocusLink)"                                                                                                                                                                                                                                                                                                                              
[19939] "The human HMGB3 Gene at Xq28 encodes HMGB3, which is an high mobility group (HMG) protein, containing 2 HMG box repeats and an acidic C-terminal domain. HMGB3 is expressed predominantly in placenta. (From OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19940] "The HMGN1 Gene at 21q22.2 encodes HMGN1, which is a member of the HMG 14/17 family of proteins. HMGB1 binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. It affects rate of elongation by RNA polymerase II on chromatin templates. HMGN1 may be involved in the process which maintains transcribable genes in a unique chromatin conformation. (From LocusLink and Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19941] "The HMGN2 Gene at 1p36.1 encodes HMGN2, which is a member of the HMG 14/17 family of proteins. HMGN2 may bind DNA with low specificity and it shares a common DNA-binding motif with other HMG 1/2 family members. It binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. HMGN2 may be involved in the process which maintains transcribable genes in a unique chromatin conformation. (From LocusLink and Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19942] "The HMGN3 Gene at 6q14.3 encodes HMGN3, which binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. HMGN3, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Two transcript variants encoding different isoforms have been found for this gene. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19943] "The HMGN4 Gene at 6p21.3 encodes HMGN4, which is a member of the HMGN protein family. HMGN4 is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Transcript variants utilizing alternative polyadenylation signals exist for this gene. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19944] "Encoded by human MAP3K8 Gene (MAP3K Family), cytoplasmic 58-kD (S and G2/M phase specific) and 52-kD isoforms of (Ser/Thr) MAP Kinase Kinase Kinase 8, produced by alternative initiation, activate MAP kinase and JNK kinase pathways in cell cycle regulation. Ser/Thr and autophosphorylated p38 MAPK activates IKB kinases, inducing proteasome-mediated proteolysis of cytoplasmic NFKB and nuclear translocation, and promotes TNF-alpha and IL-2 production during T lymphocyte activation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19945] "A group of glycoprotein growth factors regulating differentiation in mycloid cell lines. These substances act in either paracrine or autocrine fashion on marrow cells, appear to act synergistically in complex and poorly understood ways; each appears to have the ability to exert actions on several lines of progenitor cells, and to influence end cell function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19946] "Subgroups of populations based on age."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19948] "Selective replication of DNA sequence within a cell, producing multiple extra copies of that sequence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19949] "Acts on many phenolic esters. The reactions of EC 3.1.8.1 aryldialkylphosphatase, were previously attributed to this enzyme. [EC 3.1.1.2 created 1961, modified 1989] (from IUBMB Enzyme Nomenclature)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[19950] "An ATP-dependent chromatin-remodeling complex implicated in the regulation of gene expression, cell-cycle control, and oncogenesis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19951] "The Drosophila gene Imitation SWI (Iswi) encodes a DNA helicase involved in chromatin modeling. It contains a SNF2 related domain, a MYB DNA binding domain, a DEAD/DEAH box helicase, and a helicase C-terminal domain. Iswi is a component of a 215 kD protein NURF, a nucleosome remodeling complex that facilitates the perturbation of chromatin structure in an ATP-dependent manner. Iswi mediates the hydrolysis of ATP during the remodeling of chromatin. It is also a component of the ATP-utilizing chromatin assembly and remodeling factor ACF and of the chromatin accessibility complex CHRAC. This subunit may serve as the energy-transducing component of chromatin-remodeling machines. Iswi belongs to the SNF2/RAD54 helicase family, SNF2L subfamily. Similar sequences have been identified in Caenorhabditis elegans, Homo sapiens, Mus musculus, Plasmodium falciparum, and Saccharomyces cerevisiae. (from FlyBase 0011604 and NCI)"                                     
[19952] "TFIIH is a multisubunit factor consisting of at least 5 polypeptides of 92, 62, 43, 40, and 35 kD. The nonphosphorylated form of RNA polymerase II is recruited by TFIIF to the DB complex (a DNA-protein complex composed of the TATA-binding protein subunit of TFIID in association with the TATA motif and TFIIB). This complex is then recognized by TFIIE, TFIIH, and TFIIJ to generate a transcription-competent complex. Phosphorylation of the C-terminal domain of the largest subunit of RNA polymerase II controls the transition from transcription initiation to elongation. The general transcription factor TFIIH contains a kinase activity capable of phosphorylating this domain. Factors that promote the association of RNA polymerase II with the preinitiation complex stimulate this activity. TFIIE, which is required for the stable association of TFIIH with the preinitiation complex, affects the processivity of TFIIH kinase. (from OMIM 189972)"                   
[19953] "Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II and several general initiation factors. One of these factors is TFIIA, which consists of three subunits. The GTF2A1 gene encodes a large 55-kD subunit precursor that is post-translationally processed to form the 35-kD alpha (N-terminal) and 19-kD beta (C-terminal) subunits of the mature TFIIA. Together, these two subunits and the12-kD gamma subunit encoded by the GTF2A2 gene form a six strand beta-barrel that interacts with the TATA-binding protein (TBP) and a separate four-helix bundle positioned just upstream of the TBP-TATA complex. The GTF2A1 gene is located at chromosome 14q31.1 on the long arm of chromosome 14. (from OMIM 600520 and LocusLink 2957)"                                                                                                                                                                                      
[19954] "RecQ family proteins are 3'-5' DNA helicases.  All RecQ family proteins include a domain of approx. 450 amino acids that contains seven highly conserved motifs, including a 'Walker A-box' ATP-binding motif and a DExH box which is a characteristic of this family. These motifs are found in several DNA and RNA helicases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19955] "A member of RecQ helicase family. Northern blot analysis detected RECQL5 expression in almost all tissues tested, with notably strong expression in pancreas and testis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19956] "The ALF gene encodes a 69-kD protein which is a general transcription factor GTF2A1 homolog selectively expressed in testis. In comparison with the organization of GTF2A1, it has conserved regions I and IV and acidic region III but a distinct region II. ALF, in conjunction with GTF2A2 and TBP, binds DNA and allows mRNA transcription. ALF may be functionally identical with GTF2A1 and uniquely important to testis biology. The ALF gene is located at chromosome 2p16.3 on the short arm of chromosome 2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19957] "Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II and the general initiation factors. The first step involves recognition of the TATA element by the TATA-binding subunit (TBP) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF) in TFIID. The GTF2A2 gene encodes the 12-kD gamma subunit of TFIIA. The GTF2A2 gene is located at chromosome 15q21.2 on the long arm of chromosome 15. (from OMIM 600519, LocusLink 2958)"                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19958] "The assembly of transcription complexes at eukaryotic promoters involves a number of distinct steps, including chromatin remodeling and recruitment of a TATA-binding protein (TBP)-containing complexes, the RNA polymerase II holoenzyme. Each of these stages is controlled by positive and negative factors that regulate the interactions of TBP with promoter DNA. The magnitude by which an activated gene is expressed, might depend in part on competition between TBP inhibitors and the holoenzyme for access to the TBP/TATA complex. The first is autorepression, where TBP sequesters its DNA-binding surface through dimerization. Once TBP is bound to DNA, TAF(II)250 and Mot1 induce TBP to dissociate, while NC2 and the NOT complex convert the TBP/DNA complex into an inactive state. TFIIA antagonizes these TBP repressors only in conjunction with the recruitment of the RNA polymerase II holoenzyme by promoter-bound activators. (from PMID 10974559)"                 
[19959] "The DR1 gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. DR1 is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. The DR1 protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. DR1 functions as a transcriptional repressor with DRAP1 to inhibit pre-initiation complex formation through interaction with TFIID and DNA. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. This gene is located at chromosome 1p22.1 on the short arm of chromosome 1. (from LocusLink 1810)"                                                                 
[19960] "Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. The DRAP1 gene at chromosome 11q13.3 encodes a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The interaction between DRAP1 and DR1 is required for corepressor function and stabilizes the TBP-DR1-DNA complex. The DRAP1 protein contains a histone fold motif at the N terminus and a proline-rich region at the C terminus. The binding of DRAP1 to DR1 is dependent on the histone fold motif present in each protein. DRAP1 expression facilitates the maintenance of a differentiated state by silencing specific genes. (from OMIM 602289, LocusLink 10589)"                    
[19961] "Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP) and TBP-associated factors, or TAFs, in 2 distinct complexes, TFIID and B-TFIID. The majority of TBP is present in the B-TFIID complex, which is composed of TBP and BTAF1. Stable association of TBP and BTAF1 requires the presence of DNA. BTAF1 inhibits TBP-driven RNA polymerase II and III transcription by driving the dissociation of TBP from DNA and freeing the TBP to associate with other TATA boxes or TATA-less promoters. (from OMIM 605191, LocusID 9044)"                                                                                                                                                                                                                                                                                                                                                                                                             
[19962] "Containing 37 introns, the 130-kb human BTAF1 Gene (SNF2/RAD54 Helicase Family) at 10q22-q23 encodes 1849-aa, 207-kD nuclear DNA-dependent ATPase TAF-172, which harbors 7 motifs characteristic of ATPase proteins; the ATPase region shares 62% amino acid identity with yeast Mot1. RNA polymerase II transcription initiation requires TBP and TAFs in both TFIID and B-TFIID complexes. DNA-dependent association of TAF-172 with TBP forms B-TFIID and regulates transcription. TAF-172 ATPase also drives TBP dissociation from DNA, freeing TBP from the TATA box for additional transcription initiation. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                     
[19963] "The strength of noncovalent chemical binding between two substances as measured by the dissociation constant of the complex. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19965] "Catchment Area refers to the geographic area, and thus the population of individuals who qualify for consideration or inclusion in a study."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19966] "(ar-TEER-ee-o-gram) An x-ray of arteries; the person receives an injection of a dye that outlines the vessels on an x-ray."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19968] "A specialized branch of chemistry dealing with the making of compounds, generally from the building blocks to the larger or complex molecules. e.g. making protein from amino acids, or DNA from nucleotides."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19969] "A constant symbolizing the ratio of a dissolved substance in a two-phase system. (from EPA Terminology Reference System)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[19970] "A branch of pathology that studies and diagnoses diseases on the cellular level. The most common use of cytopathology is the Pap smear, used to detect cervical cancer at an early treatable stage. (Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19971] "The catalyzed removal of phosphate groups from biological molecules, by phosphatases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[19972] "Multiplication or reproduction by cell division of a population of identical cells descended from a single progenitor. In immunology, may refer to the clonal proliferation of cells responsive to a specific antigen as part of an immune response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19973] "A method to synthesize cDNA for determining the 5'-untranslated region of a specific mRNA molecule through reverse transcription reaction using complementary oligonucleotides as primers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19974] "Cancer Family is a group of blood relatives of whom several have had cancer; the mode of aggregation may be genetic and homogeneous, as in familial polyposis of the colon; diverse as in neurofibromatosis; or due to common exposure to a carcinogenic or oncogenic agent, such as a virus. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19975] "The percentage of individuals in a population with a non-parental genotype."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19976] "Genes that are expressed at a fairly consistent level throughout the cell cycle and from tissue to tissue.  Usually involved in routine cellular metabolism. Often used for comparison when studying expression of other genes of interest."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19977] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19979] "Taste; the faculty of taste, distinguishing substances by means of the taste buds."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19980] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19981] "Fusion of 2 somatic cells to form a heterokaryon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[19982] "The study of the immune factors that affect the functioning of the human body"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[19983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19984] "Local spread of a malignant neoplasm by infiltration or destruction of adjacent tissue; for epithelial neoplasms, invasion signifies infiltration beneath the epithelial basement membrane."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19985] "The turnover or rate of change of a substrate due to the action of a specific enzyme, or biological catalyst, commonly expressed as units of amount per unit time. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[19986] "In vitro mutagenesis technique in which molecules containing 3' and 5' deletion mutations are combined to regenerate an entire DNA region, differing with the wild type molecule only at the junction of the molecules, which contains a linker DNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19987] "Formation of melanin"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[19988] "A silent mutation alters DNA sequence, but has no apparent detectable effect on a phenotype or a function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19989] "The origin or causation of a disease of the nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[19990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19991] "Deranged function in an individual or an organ that is due to a disease. (MedicineNet.com)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[19992] "A branch of pharmacology that studies the biochemical mechanisms responsible for the actions of pharmacologic substances."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19993] "RAEB: the scientific discipline of the application of physics to the use of ionizing radiation in therapy and in diagnostic radiology; including, by extension, nuclear medicine applications, ultrasound, and magnetic resonance imaging. (STED98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[19994] "Encoded by Polymerase Genes, Polymerase enzymes catalyze polymerization reactions, especially of nucleotides to polynucleotides. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[19995] "Transcription factor SP1 is a DNA-binding protein that interacts with various RNA polymerase II gene promoters containing GC-box elements.  It has contiguous zinc finger motifs and requires zinc for sequence-specific binding to DNA.  The formation of head segments in Drosophila depends on the homologue of the human transcription factor SP1.  (from OMIM 189906 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[19996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19997] "The mismatch repair (MMR) system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. This function is critically dependent on the assembly of multimeric complexes involved in mismatch recognition and signal transduction to downstream repair events. (PMID: 11687886)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[19998] "(o-MY-a REZ-er-vwahr) A device surgically placed under the scalp and used to deliver anticancer drugs to the fluid surrounding the brain and spinal cord."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[19999] "A measure of how well a patient is able to perform ordinary tasks and carry out daily activities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20000] "(stair-ee-o-TAK-sis) Use of a computer and scanning devices to create three-dimensional pictures. This method can be used to direct a biopsy, external radiation, or the insertion of radiation implants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20001] "(SHIL-er) A test in which iodine is applied to the cervix. The iodine colors healthy cells brown; abnormal cells remain unstained, usually appearing white or yellow."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20002] "Defined as thin section (1-2 mm collimation) CT optimized by using a high-spatial-frequency (bone) algorithm. (from Radiol Clin North Am 1991;29:1043-9)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20003] "A detailed picture of areas inside the body.  The pictures are created by a computer linked to an x-ray machine that scans the body in a spiral path.  Also called helical computed tomography."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20004] "Enzymes that change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA; type I topoisomerase of E. coli (omega protein) relaxes negatively supercoiled DNA and does not act on positively supercoiled DNA. Type II topoisomerases cut both strands of DNA; type II topoisomerase of E. coli (DNA gyrase) increases the degree of negative supercoiling in DNA and requires ATP. It is inhibited by several antibiotics, including nalidixic acid and ovobiocin. (The Dictionary of Cell Biology, 2nd ed., http://www.mblab.gla.ac.uk/~julian/dict.html)"                                                                                                                                                                                                                                                                                                                                                                            
[20005] "TFIIE Subunit Genes encode 2 subunit proteins of 56 kD and 34 kD. TFIIE is a heterotetramer of 2 alpha and 2 beta subunits, both subunits being required for optimal basal-level transcription. Both subunits are essential to form a stable preinitiation complex. High levels of gene transcription by RNA polymerase II depend on high rates of transcription initiation and reinitiation. Initiation requires recruitment of the complete transcription machinery to a promoter, a process facilitated by activators and chromatin remodeling factors. Reinitiation occurs through a different pathway. After initiation, a subset of the transcription machinery remains at the promoter, forming a platform for assembly of a second transcription complex as a scaffold for formation of a functional reinitiation complex. Formation of this scaffold depends on ATP and TFIIH. Some activators and Mediator may promote high levels of transcription. (from OMIM 189962)."                 
[20006] "The TFIIB gene encodes a protein that is a general transcription factor and plays a central role in preinitiation complex assembly. TFIIB is one of the ubiquitous factors required for transcription initiation by RNA polymerase II. TFIIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. TFIIB provides a bridge between promoter-bound TFIID and RNA Polymerase II. TFIIB possesses sequence-specific DNA-binding ability and interacts with the TFIIB -recognition element (BRE), present in many promoters. BRE suppresses the basal level of transcription elicited by a core promoter, which increases the amplitude of transcriptional stimulation in the presence of an activator where an activator can disrupt the TFIIB-BRE interaction within a promoter-bound complex. The TFIIB gene is located at chromosome 1p22-p21 on the short arm of chromosome 1. (from PMID 11711430, LocusLink 2959)"                         
[20007] "The GTF2E1 gene encodes a 56-kD protein that is the alpha subunit of RNA polymerase II transcription initiation factor IIE. GTF2E1 is required in vitro with GTF2E2 for the formation of a stable preinitiation complex and for basal-level and Sp1-activated transcription. This gene is located at chromosome 3q21-q24 on the long arm of chromosome 3. (from LocusLink 2960)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20008] "The GTF2E2 gene encodes a 34-kD protein that is the beta subunit of RNA polymerase II transcription initiation factor IIE. GTF2E2 is required in vitro for the formation of a stable preinitiation complex and for basal-level and Sp1-activated transcription. The GTF2E2 gene is located at chromosome 8p21-p12 on the short arm of chromosome 8. (from LocusLink 2961)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20009] "Human TFIIF Subunit Genes, GTF2F1 Gene and GTF2F2 Gene, encode similar alpha (517-aa, 58-kDa, phosphorylated) and beta (249-aa, 28-kDa) subunits of heterodimeric nuclear general transcription initiation factor TFIIF, which binds to and recruits RNA polymerase II to the initiation complex in collaboration with TFIIB. The beta subunit shows ATP-dependent DNA-helicase activity and the region that binds RNA polymerase exhibits similarities with prokaryotic sigma factors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20010] "The GTF2F1 gene encodes a 74-kD protein that is the large subunit of TFIIF, one of at least six general transcription factors participating in accurate initiation by RNA polymerase II. TFIIF can bind directly to RNA polymerase II and decrease the affinity of RNA polymerase II for nonspecific DNA. TFIIF acts at an intermediate stage in initiation complex formation after TFIID firmly associates with DNA, but coincidentally with or immediately after RNA polymerase II binding to DNA, and before the recruitment of TFIIE. GTF2F1 lacks obvious DNA or RNA helicase motifs. GTF2F1 interacts with GTF2F2, the small subunit of TFIIF, to direct accurate transcription initiation by RNA polymerase II. This interaction is necessary for transcriptional activation by serum response factor. The GTF2F1 is located at chromosome 19p13.3 on the short arm of chromosome 19. (from OMIM 189968, OMIM 600246)"                                                                       
[20011] "The GTF2F2 gene encodes a 30-kD protein that is the small subunit of the RNA polymerase II transcription factor TFIIF. TFIIF affects RNA polymerase II activity both during the initiation and elongation stages of RNA transcription. TFIIF assists TFIIB in recruiting RNA polymerase II into a preinitiation complex. It also affects RNA transcription by suppressing transient pausing of the polymerase at locations on the DNA template. These 2 activities are controlled by distinct functional domains. The initiation activity is mediated by GTF2F2 C-terminal sequences (which include a DNA binding domain) and the elongation activity is mediated by sequences immediately upstream of the C-terminus, where RNA polymerase II is thought to bind, as well as by sequences near the GTF2A2 N-terminus. The GTF2A2 gene is located at chromosome 13q14 on the long arm of chromosome 13. (from OMIM 189969)"                                                                         
[20012] "For transcription initiation, the nonphosphorylated RNA polymerase II is recruited by TFIIF to the DB complex. This complex is recognized by TFIIE, TFIIH, and TFIIJ to form a transcription-competent complex. Phosphorylation of the C-terminal domain of the largest subunit of RNA polymerase II controls the transition from transcription initiation to elongation and TFIIH contains a kinase activity for phosphorylating this domain. Factors that promote the association of RNA polymerase II with the preinitiation complex stimulate this activity. TFIIE, which is required for the stable association of TFIIH with the preinitiation complex, affects the processivity of TFIIH kinase. TFIIH is a multisubunit factor of at least 5 proteins of 92, 62, 43, 40, and 35 kD. A 52-kD subunit has also been identified as a component of the TFIIH core, along with p89, p62, p44, and p34. (from OMIM, LocusLink and NCI)"                                                           
[20013] "Human TFIIH Core Subunit Genes, GTF2H1, GTF2H2, GTF2H3, GTF2H4, ERCC2, and ERCC3, encode six subunits of the nuclear core-TFIIH basal transcription factor. These subunits are involved in transcription-coupled DNA nucleotide excision repair, and basal RNA polymerase II transcription when complexed to CAK (CDK7/Cyclin H/MAT1). Phosphorylated 548-aa 62-kDa GTF2H1 contains 2 BSD domains. The 395-aa 44-kDa GTF2H2 contains a C4-type zinc finger and a VWFA domain. The N-terminus interacts with and regulates XPD, while the C-terminus promotes escape of RNAPII from the promoter. GTF2H2 also interacts with XPB, p62, and p34. Containing a C4-type zinc finger, 303-aa 34-kDa GTF2H3 anchors XPB. ATP-dependent 760-aa 87-kDa ERCC2 DNA helicase anchors CAK to core-TFIIH; interaction with p44 stimulates helicase activity. ERCC3 is a 782-aa 89-kDa ATP-dependent DNA helicase. (NCI)"                                                                                         
[20014] "The GTF2H1 gene encodes a 62-kD protein that is a subunit of TFIIH, a multisubunit factor consisting of at least 10 proteins. TFIIH is involved in several biological fundamental mechanisms of the cell: transcription, nucleotide excision repair and cell cycle regulation. p62 is one of the six subunits that constitutes the core of TFIIH versus the holoenzyme, which contains, in addition, the ternary kinase CAK complex. p62 does not contain any known specific motif or enzymatic activities and may only have an architectural role, around which the other proteins with specific functions. The p62 promoter has two start sites and the regulatory regions, but lacks classical elements such as CCAAT and TATA boxes. The p62 gene is expressed in testis tissue. The GTF2H1 gene is located at chromosome 11p15.1-p14 on the short arm of chromosome 11. (from PMID 11266560, PMIM 9630526)"                                                                                    
[20015] "Human ERCC2 Gene (RAD3/XPD Family) encodes 760-aa 87-kDa nuclear DNA Excision Repair Protein ERCC2, an ATP-dependent 5 prime-3 prime DNA helicase and one of six integral subunits of the basal transcription factor BTF2/TFIIH complex. Recruited by transcription preinitiation or DNA damage recognition complexes, ERCC2 is involved in RNA polymerase II transcription, transcription-coupled nucleotide excision DNA repair, and cell cycle regulation. ERCC2/MAT1 anchors CAK complex to the TFIIH complex. CAK inhibits ERCC2 helicase activity; overcome by binding TFIIH subunit p44, which stimulates helicase activity. ERCC2 defects result in XPD, XPD/CS, TTD, and COFS Syndrome. (NCI)"                                                                                                                                                                                                                                                                                             
[20016] "Regulation of mRNA synthesis requires intermediary proteins that transduce regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Mediator Complex Component Genes encode the mediator complex, one type of intermediary and which consists of approximately 20 polypeptides. It is physically associated with RNA polymerase II and is essential for transcriptional activation. (from OMIM 602984)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20017] "Human MED6 Gene (MED6 Family) encodes 246-aa 28-kDa nuclear Mediator of RNA Polymerase II Transcription Subunit 6 Homolog, a coactivation component of transcriptional mediator complexes involved in transcriptional activation and repression. Transcription requires intermediary proteins that transduce signals from regulatory activator proteins to the basal transcription machinery at the core promoter. Physically associated with RNA polymerase II and essential for transcriptional activation, MED6 appears required for transcriptional activation of most of the RNA polymerase II-transcribed genes and not to be involved in uninduced or repressed transcription, transcription of constitutively expressed genes, or transcription by RNA polymerases I or III. MED6 is a subunit of the multiprotein ARC/DRIP and CRSP complexes. (NCI)"                                                                                                                                      
[20018] "RNA polymerase II subunit genes encode DNA-dependent RNA polymerase II, a complex multisubunit enzyme that is responsible for the transcription of protein-coding genes. Ten to 14 subunits encoded by these genes range in size from 220 to 10 kD. The complex interacts with the promoter regions of genes as well as with a variety of elements and transcription factors to determine essentially all of the parameters that govern transcription, e.g., tissue and development specificity, stress response, etc. A fraction of the large subunit of Pol II (Pol II LS) is ubiquitinated after exposing cells to UV radiation or cisplatin. (NCI)"                                                                                                                                                                                                                                                                                                                                             
[20019] "Human POLR2A Gene (RNA Polymerase Beta Prime Chain Family) encodes nuclear 1970-aa 220-kD DNA Directed RNA Polymerase II Polypeptide A, the largest of 12 subunits of RNA polymerase II that catalyzes transcription of DNA in eukaryotes into mRNA precursor. The C-terminal domain (CTD) heptapeptide repeats contain highly phosphorylated activating serine and threonine residues. POLR2A and other subunits form the polymerase DNA binding domain, where the DNA template is transcribed. POLR2A couples transcription with pre-mRNA processing. The hyperphosphorylated CTD interacts with FNBP3 and recruits factors for mRNA capping, splicing, and 3'-processing. POLR2A interacts with SAFB/SAFB1. POLR2A is ubiquitinated after damage of genes repaired by transcription-coupled repair.  (NCI)"                                                                                                                                                                                      
[20020] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20021] "RNA polymerases are unable to initiate RNA synthesis in the absence of general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. TFIIIC Subunit Genes encode the TFIIIC protein complex that is essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. The TFIIIC complex interacts with TFIIIB in the recruitment of RNA polymerase III. Transcription by RNA polymerase III is enhanced during viral infection by the expression of immediate early proteins of adenovirus and pseudorabies virus. (from OMIM 604888)"                                                                                                                                                                                                                                                                                 
[20022] "The GTF3C3 gene encodes a 102-kD protein that is a subunit of GTF3C and contains N-terminal basic and acidic regions, a central acidic region, a C-terminal helix-loop-helix region, and 11 tetratricopeptide repeats. The GTF3C complex interacts with GTF3B in the recruitment of RNA polymerase III. The GTF3C3 gene is located at chromosome 2q33.1 on the long arm of chromosome 2. (from OMIM 604888)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20023] "The GTF3C1 gene encodes a 220-kD protein that is a subunit of general transcription factor GTF3C, a component of RNA polymerase III. GTF3C is a multisubunit complex that binds B box promoter elements. GTF3C1 binds to the box B promoter element. GTF3C1 is absolutely required for RNA polymerase III transcription of 5S RNA, tRNA, and VAI RNA genes. The GTF3C1 gene is located at chromosome 16p12 on the short arm of chromosome 16. (from OMIM 603246, LocusLink 2975)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20024] "The GTF3C2 gene at 2p23.3 encodes a 110-kD protein that is the beta subunit of general transcription factor GTF3C, a component of RNA polymerase III. RNA polymerases need general transcription factors (GTFs) to initiate RNA synthesis. GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. GTF3C2 is expressed in all 16 human tissues examined with moderate expression in lung, skeletal muscle, kidney, ovary, and colon and low in heart, brain, placenta, liver, pancreas, spleen, thymus, prostate, testis, small intestine, and peripheral blood leukocytes. The GTF3C2 protein contains stretches of acidic and basic regions, potential acidic and basic helices, and 5 putative WD40 repeats. (from OMIM 604883, LocusLink 2976)"         
[20025] "The GTF3C4 gene encodes a 90-kD protein that is a subunit of general transcription factor GTF3C. RNA polymerases need general transcription factors (GTFs) to initiate RNA synthesis. GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. The GTF3C4 protein interacts with GTF3B in the recruitment of RNA polymerase III. GTF3C4 has intrinsic histone acetyltransferase activity. GTF3C4 contains 2 potential zinc finger motifs at the C-terminus. The GTF3C4 gene is located at chromosome 9q34.3 on the long arm of chromosome 9. (from OMIM 604892, LocusLink 9329)"                                                                                                                                                                             
[20026] "The GTF3C5 gene encodes a 63-kD protein that is a subunit of general transcription factor GTF3C. RNA polymerases need general transcription factors (GTFs) to initiate RNA synthesis. GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. The GTF3C complex interacts with GTF3B in the recruitment of RNA polymerase III. The GTF3C5 protein contains a central helix-turn-helix motif and a C-terminal acidic region. The GTF3C5 gene is located at chromosome 9q34 on the long arm of chromosome 9. (from OMIM 604890, LocusLink 9328)"                                                                                                                                                                                                              
[20027] "Human TFIIIB Subunit Genes, BDP1, BRF1, and, BRF2, encode protein subunits of RNA Polymerase III Transcription Initiation Factor IIIB, required for RNA polymerase III transcription. Transcription begins with TFIIIC recognition of promoter A and B boxes and TFIIIA, TFIIIB, and RNA polymerase III binding. 90-kDa BRF1 contains a C-terminal HMG2-related region and an N-terminal TFII2B-related sequence. 50-kDa BRF2 has a zinc ribbon domain and a core domain, necessary for complex formation with DNA. Involved in nucleation of a polymerase III initiation complex, BRF2 does not directly bind DNA but interacts with TBP, which binds cooperatively to the promoter. TBP, an essential component of TFIIIB, binds the highly charged C-terminus of BRF1. Highly hydrophilic BDP1 contains a DNA-ligase A1 ATP-dependent binding site and several potential phosphorylation sites. (NCI)"                                                                                           
[20028] "The BRF1 gene at 14q encodes a 90-kD protein that is a subunit of RNA polymerase III, TFIIIB. BRF1 is essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and virus-associated RNA. Transcription of these RNAs begins with TFIIIC recognition of internal promoter elements (A and B boxes), followed by sequential binding of TFIIIB and RNA polymerase III. 5S RNA transcription is similar except that the binding of TFIIIA to a distinct set of internal promoter elements is required for TFIIIC recruitment. An essential component of TFIIIB, TATA box-binding protein (TBP), is required by all 3 classes of eukaryotic RNA polymerases. The C terminus of BRF1 binds TBP. BRF1 contains a high mobility group protein-2 (HMG2)-related region in the highly charged C terminus and a sequence related to TFII2B in the N terminus. Deletion of either half of the protein abolished activity. (NCI)"                        
[20029] "The BDP1 Gene encodes a highly hydrophilic protein that is a subunit of RNA Polymerase III Transcription Initiation Factor IIIB.  BPD1 is required for transcription from the Ad2 VAI and human U6 RNA polymerase III promoters.  BDP1 binds the U6 promoter region in vivo as part of the U6 initiation complex.  The BDP1 protein contains a bipartite nuclear localization signal, a DNA-ligase A1 ATP-dependent binding site, and a second bipartite nuclear localization signal in the C terminus.  The protein has several potential phosphorylation sites.  Weak expression of 9.5-, 3.1-, and 1.6-kb transcripts is detected in all tissues examined, and a 1.9-kb transcript expressed only in brain.  A strong signal is present at 9.5 and 1.9 kb in cerebellum, and a weak signal in all other brain areas.  Adult human tissues show 5 protein bands ranging from 55 to 250 kD.  The BDP1 gene is located at chromosome 5q13 on the long arm of chromosome 5.  (from OMIM)"            
[20030] "The BRF2 gene encodes a 50-kD protein that is a subunit of RNA polymerase III transcription initiation factor. BRF2 is involved in the nucleation of a polymerase III-specific small nuclear RNA (snRNA) transcription initiation complex. BRF2 does not directly bind DNA but it interacts with the TATA-binding protein (TBP), and they then bind cooperatively to the polymerase III promoter region of snRNA. The BRF2 protein has a zinc ribbon domain and a core domain. The TBP/BRF2 complex does not have strict requirements for sequence motifs outside the TATA box. Arg235 and phe250 of TBP, and repeat 2 of the BRF2 core domain, are necessary for complex formation with DNA. BRF2 also forms a stable complex on the TATA box of the polymerase II-specific adenovirus major late promoter. The BRF2 gene is located at chromosome 8p11.23 on the short arm of chromosome 8. (from OMIM 607013, LocusLink 55290, and NCI)"                                                         
[20031] "RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. A second group of cofactors includes PC1, PC2, and PC3, which have a strong positive influence on transcription. The combined action of general and gene-specific regulators encoded by Transcription Coactivator Genes enhances gene expression. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                     
[20032] "A human early embryonic event in which in any given cell one of a female's two X chromosomes becomes inactivated and converted into a Barr body.  After inactivation has occurred, all descendants of that cell have the same inactivated X chromosome. Thus, X-inactivation creates cell clones with differing effective gene content. An organism whose cells vary in effective gene content and hence in the expression of a trait, is called a genetic mosaic."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20033] "The PC4 gene encodes Activated RNA Polymerase II Transcription Cofactor 4, which is a general transcriptional coactivator for RNA polymerase II. This protein mediates transcriptional activation of class II genes. It is a single-stranded DNA-binding protein that functions through its interaction with TAFs. (from OMIM, LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20034] "The PSIP1 gene at 9p22.2 encodes 2 transcriptional coactivators (p52 and p75) that are alternatively spliced products. The p52 and p75 proteins share a region, but show distinct coactivator properties. Both p52 and p75 interact strongly with the VP16 activation domain and several components of the general transcriptional machinery. p52 is a potent broad-specificity coactivator, whereas p75 is less active for most activation domains. p52 interacts not only with transcriptional activators and general transcription factors to enhance activated transcription, but also with the essential splicing factor ASF/SF2 to modulate ASF/SF2-mediated pre-mRNA splicing. The majority of endogenous p52 is colocalized with ASF/SF2 in the nucleoplasm. In addition to functioning as a transcriptional coactivator, p52 may also act as an adaptor to coordinate pre-mRNA splicing and transcriptional activation of class II genes. (from OMIM 603620)"                              
[20035] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20036] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20037] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20038] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20039] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20040] "The PPARBP gene at 17q12-q21.1 encodes a 220-kD protein that is global transcription coactivator for the nuclear receptor superfamily. Two LXXLL motifs in PPARBP are necessary and sufficient for binding to nuclear receptors, including thyroid hormone receptor and estrogen receptor. PPARBP is essential for many physiologic processes and also has gene- and activator-selective functions. PPARBP is required for PPAR gamma 2-stimulated adipogenesis and may play a role in mammary epithelial differentiation and breast carcinogenesis. High levels of PPARBP expression are detected in primary breast cancers and breast cancer cell lines. This can happen independent of gene amplification though the latter occurs. PPARBP, in a protein-protein interaction, regulates p53 transactivating activity. An 8.5-kb transcript is expressed in all tissues examined except kidney, with highest expression in heart. (from OMIM, LocusLink)"                                         
[20041] "Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP2 gene at Xp11.4-p11.2 encodes a 150-kD protein that is a subunit of the CRSP complex. The CRSP2 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. CRSP2 contains a cytochrome C family heme-binding motif and a bipartite nuclear localization signal. CRSP2 is expressed as 6.5- and 8-kb mRNAs predominantly in skeletal muscle. (from OMIM 300182, LocusLink 9282)" 
[20042] "Chromogranin B is a tyrosine-sulfated secretory protein found in a wide variety of peptidergic endocrine cells.  Chromogranin functions as a neuroendocrine secretory granule protein which may be the precursor for other biologically active peptides. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20043] "The protein is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins.  Studies in rodents suggest that the full length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles.  The full length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20044] "Sp1 Activation Cofactor Genes encode (at least 9) protein subunits of the CRSP (Cofactor Required for SP1 activation) complex, which, along with TFIID, is required for efficient activation of gene transcription by SP1, a transcription factor that recognizes enhancer sites in target DNA. Many CRSP complex proteins are also components of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                               
[20045] "Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation) along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP3 gene encodes a 130-kD protein that is a subunit of the CRSP complex. The CRSP3 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. The CRSp3 gene is located at chromosome 6q22.33-q24.1 on the long arm of chromosome 6. (from OMIM 605042, LocusLink 9439)"                                                                                                                   
[20046] "Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. CRSP (cofactor required for SP1 activation), along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD and 9 polypeptides have been identified as CRSP subunits. The CRSP6 gene encodes a 77-kD protein that is a subunit of the CRSP complex. The CRSP6 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. The CRSP6 gene is ubiquitously expressed as an approximately 3.0-kb transcript. The CRSP6 gene is located at chromosome 11q14 on the long arm of chromosome 11. (from OMIM 603810, LocusLink 9440)"                                                                   
[20047] "Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP7 gene encodes a 70-kD protein that is a subunit of the CRSP complex. The CRSP7 protein is required for Sp1-mediated transcriptional activation with TAF(II)s. It amino terminus is similar to elongation factor TFIIS. The CRSP7 gene is located at chromosome 19p13.12 on the short arm of chromosome 19. (from OMIM 605043, LocusLink 9441)"                                                             
[20048] "Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP8 gene encodes a 34-kD protein that is a subunit of the CRSP complex. The CRSP protein is required for Sp1-mediated transcriptional activation with TAF(II)s. The CRSP8 gene is located at chromosome 9q34.3 on the long arm of chromosome 9. (from OMIM 605044, LocusLink 9442)"                                                                                                                    
[20049] "Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD and 9 polypeptides have been identified as CRSP subunits. The CRSP9 gene encodes a 33-kD protein that is a subunit of the CRSP complex. The CRSP9 protein is required with the TAF(II)s for Sp1-mediated transcriptional activation. The CRSP9 gene is located at chromosome 5q33.2 on the long arm of chromosome 5. (from OMIM 605045, LocusLink 9443)"                                                                                                                      
[20050] "Nuclear receptor coactivator genes encode a class of proteins that are recruited and serve as bridging molecules between the transcription initiation complex and nuclear receptors (NRs). Most of these coactivators interact with the AF-2 domain of NRs through one or several LXXLL motifs called NR box. Members of NRs includes the 5 steroid receptors and class II nuclear receptors. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                               
[20051] "family of cystine-rich proteins that tend to aggregate in side-to- side fashion, forming tough filaments or sheets; main constituent of intermediate filaments in epidermal tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20052] "Encoded by Intermediate Filament Genes, diverse Intermediate Filament Proteins (including keratin filaments, neurofilaments, desmin, and vimentin) form polymeric structural cytoplasmic filaments, intermediate in diameter (8-10 nanometer) between actin microfilaments and microtubules, that comprise part of the cytoskeleton of most eukaryotic cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20053] "The NCOA1 gene at 2p23 encodes a 160-kD protein that is a coactivator required for full transcriptional activity of the steroid receptor superfamily. NCOA1 enhances the transcriptional activity of hormone-bound progesterone receptor (PGR), estrogen receptor (ESR), glucocorticoid receptor (GRL), thyroid hormone receptor, and retinoid X receptor but does not alter the basal activity of the target promoter. It is a limiting factor for efficient PGR and ESR transactivation. NCOA1 binds to TBP and to TFIIB and bridges between nuclear hormone receptors and general transcription factors. NCOA1 is involved in both chromatin remodeling and the process of recruitment/stabilization of general transcription factors and can enhance the transcriptional activities of SP1. Three mRNA splicing variants encode 3 isoforms: SRC1, SRC1E, and SRC1(-Q). SRC1E mRNA is more abundantly expressed than SRC1 or SRC1(-Q) mRNAs in all tested cell lines. (NCI)"                     
[20054] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20055] "Involved in cell growth, development, and homeostasis, 292-kb human NCOA2 Gene at 8q13.2 encodes 1464-aa 159-kD transcriptional coactivator TIF2, containing N-terminal bHLH and PAS dimerization domains. Present in a complex with NCOA3, IKKA/B, IKBKG, and CREBBP histone acetyltransferase, TIF2 interacts with HIF1A, APEX, NR3C1, and perhaps NR3C2. TIF2 coactivator interacts with steroid receptor superfamily hormone binding domains in a hormone-dependent manner. Recruitment of CBP/p300 and PCAF coactivators for myogenic MYOD and MEF2 expression depends on NCOA1, NCOA2, and NCOA3. NCOA2 is also required for expression of MYOG and CDKN1A, and for myogenic differentiation. The NCOA2 bHLH/PAS and C-terminal activation domains mediate coactivation of MEF2C through its MADS box. The NCOA2 N- and C-termini interact with MYOG. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                            
[20056] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20057] "The NCOA3 gene at 20q12 encodes a 160-kD nuclear receptor coactivator. The NCOA3 protein enhances the transactivation activities of nuclear receptors in mammalian cells in hormone-dependent fashion. NCOA3 directly binds nuclear hormone receptors, including RAR, thyroid hormone receptor, VDR, and estrogen receptor. NCOA3 recruits CBP and PCAF, creating a multisubunit coactivator complex to allow transmission of the hormonal signal to the transcriptional machinery. NCOA3 has a basic helix-loop-helix domain in the N-terminus, at least 2 receptor-interaction domains (RIDs) in the central region, and a CBP-interaction domain (CID) and a histone acetyltransferase (HAT) domain in the C-terminus. While ubiquitously expressed in normal human tissues, NCOA3 is amplified and overexpressed in breast and ovarian cancer cell lines and in breast cancer biopsies. Altered NCOA3 expression may contribute to development of steroid-dependent cancers. (NCI)"             
[20058] "The NCOA5 gene encodes a protein that is a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The NCOA5 protein localizes to the nucleus and has both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. The NCOA5 gene is located at chromosome 20q12-q13.12 on the long arm of chromosome 20. (from LocusLink 57727)"                                                                                                                                                                                                                                                                                                                     
[20059] "Alcohol Abuse; the use of alcoholic beverages to excess, either on individual occasions (\"binge drinking\") or as a regular practice."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20060] "Nuclear hormone receptors activate gene transcription through ligand-dependent association with coactivators. The NCOA6 gene at 20q11 encodes a 250-kD protein that is a nuclear receptor coactivator. NCOA6 interacts with multiple members of the nuclear receptor family, including THRB and estrogen receptor. The first copy of the two LXXLL domains in the NCOA6 protein is functional in ligand-dependent interaction with the AF2 domain of nuclear receptors and mutation of this sequence abolishes transcriptional enhancement. NCOA6 strongly transactivates through THRB and estrogen receptor in a dose-related and ligand-dependent manner. Increased NCOA6 copy number is found in 10% of breast cancer specimens and in all breast cancer cell lines. NCOA6 is widely expressed with highest expression in brain and reproduction organs, such as ovary, testis, and prostate. (from OMIM 605299, PMID 10681503)"                                                                 
[20061] "RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. Transcription Corepressor Genes encode a group of transcriptional repressor/co-repressor factors that suppress transcription by binding to the operator. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20062] "Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20063] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20064] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20065] "The SHP gene at 1p36.1 encodes a protein that interacts with some members of the nuclear hormone receptor superfamily, including retinoid receptors RAR and RXR, thyroid hormone receptor, and the orphan receptor MB67. The SHP protein contains the ligand-binding and dimerization domains found in other superfamily members but lacks the conserved DNA-binding domain. SHP specifically inhibits transactivation by the superfamily members with which it interacts as a negative regulator of receptor-dependent signaling pathways. The SHP mutations result in the loss of SHP activity and are associated with early-onset mild obesity. A 1.3-kb SHP transcript is detected in human liver with lower levels of expression in heart and pancreas. SPH expression is detected in adult small intestine, adult spleen, fetal liver, and fetal adrenal gland of human tissues. (from OMIM 604630)"                                                                                          
[20066] "Orphan Nuclear Receptor Genes (NR Superfamily) encode numerous Orphan Nuclear Receptor (NRs) transcription factors thought to be activated by as yet unknown ligands. Transducing cellular signals into gene transcription, NRs regulate development, pattern formation, cell proliferation, cell differentiation, and homeostasis in target tissues. NRs share a common organization: an (N) modulatory domain, a conserved central Cys-rich region of two C4 zinc fingers that bind to specific upstream ligand-responsive target DNA elements, and a (C) ligand-binding domain. Stabilizing hydrophobic zinc finger interactions contribute to DNA binding specificity, homodimerization, and interaction with other proteins. Ligand-bound NR conformation allows coactivator interaction with the ligand-binding domain that mediates interaction with heat shock proteins, cyclophilins, and ligand. (NCI)"                                                                                   
[20067] "Nuclear Receptor Genes (NR Superfamily) encode over 300 ligand-dependent Nuclear Receptor (NRs) transcription factors: steroid, retinoid, vitamin D, TH, and orphan receptors (unknown ligands). Transducing hormone signals into gene transcription, NRs regulate development, pattern formation, cell proliferation, cell differentiation, and homeostasis in target tissues. NRs share a common organization: an (N) modulatory domain, a conserved central Cys-rich region of two C4 zinc fingers that bind to specific upstream ligand-responsive target DNA elements, and a (C) ligand-binding domain. Stabilizing hydrophobic zinc finger interactions contribute to DNA binding specificity, homodimerization, and interaction with other proteins. Ligand-bound NR conformation allows coactivator interaction with the hormone-binding domain that mediates interaction with heat shock proteins, cyclophilins, and hormone. (NCI)"                                                       
[20068] "RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. A second group of cofactors includes PC1, PC2, and PC3, which have a strong positive influence on transcription. A third group of factors suppress transcription. The combined action of general and gene-specific regulators encoded by transcription coactivator genes determines appropriate gene expression. (NCI)"                                                                                                                                                                                                                                                                                                                                             
[20069] "The Sp1 gene encodes a DNA-binding protein that is a member of the Sp-family of zinc-finger transcription activators. The Sp1 protein interacts with a variety of cellular and viral promoters containing GC-box elements. Profound changes in patterns of gene expression can result from relatively small changes in the concentrations of sequence-specific transcription factors. Synergistic interaction occurs between factors bound to different sites within a transcriptional control region. Sp1 has contiguous zinc finger motifs and requires zinc for sequence-specific binding to DNA. The SP1 gene is located at chromosome 12q13.1 on the long arm of chromosome 12. (from OMIM 189906, LocusLink 6667)"                                                                                                                                                                                                                                                                            
[20070] "Human CRSP4 Gene, chromosome location unknown, encodes the 100-kD subunit 4 protein of the CRSP (Cofactor Required for SP1 activation) complex, which, along with TFIID, is required for efficient activation of gene transcription by SP1, a transcription factor that recognizes enhancer sites in target DNA. Many CRSP complex proteins are also components of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                              
[20071] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20072] "Human AMPH Gene (Amphiphysin Family) at 7p14-p13 is expressed in neurons, certain endocrine cells, and spermatocytes. Alternatively spliced Amphiphysin isoforms of 128- and 108 kD are produced that may regulate synaptic and endocrine exocytosis. Heterodimeric with AMPHL, AMPH is a non-intrinsic acidic membrane protein concentrated in nerve terminals and associated with the cytoplasmic face of synaptic vesicles. The N- and C-termini are highly conserved between chicken and human; the C-terminal region contains an SH3 domain. AMPH may control membrane associated cytoskeleton properties and protein dysfunction is associated with Stiff-Man Syndrome. (from LocusLink 273, Swiss-Prot P49418, OMIM 600418, and NCI)"                                                                                                                                                                                                                                                        
[20073] "Human BARD1 Gene at 2q34-q35 encodes nuclear BARD-1 Protein containing RING-type zinc finger, ANK repeats, and BRCT domains. The BARD-1 N-terminus heterodimerizes with BRCA1. BARD1/CSTF1 complex interacts with RNA Polymerase-2, which may inhibit pre-mRNA cleavage or polyadenylation. BARD-1 may be a part of the RNA Polymerase-2 holoenzyme that senses DNA damage; inhibition by CSTF1 may prevent erroneous polyadenylation at such sites. BARD-1 may mediate apoptosis and is processed during apoptosis. BARD-1 homodimer is more susceptible to proteolysis than BARD1/BRCA1. BARD-1 co-localizes in S phase with BRCA1 in subnuclear foci. BARD1/BRCA1 disrupted by tumorigenic BRCA1amino acid substitutions; BARD1/BRCA1 may be essential to BRCA1 tumor suppression. BARD1 defects occur in primary breast, ovarian, and uterine cancers. (from Swiss-Prot Q99728, OMIM 601593, and NCI)"                                                                                          
[20074] "The serine hydrolase genes encode a functional class of hydrolytic enzymes that contain a serine residue in their active site. The serine hydrolases can be grouped into subfamilies that contain closely related members in terms of substrate specificity or amino acid sequence similarity. (from OMIM 603156)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20075] "Human BPHL Gene (Serine Hydrolase Family) at 6p25 spans approximately 30 kb with eight exons that encode a 30 kD 274-amino acid Biphenyl Hydrolase-Related Protein, with a putative role in detoxification processes and structurally similar to enzymes involved in degradation of aromatic compounds. A major 1.8 kb BPHL transcript is expressed, with highest levels in liver and kidney; a minor 2.4 kb transcript is also expressed. Serine hydrolases contain serine in their active site and are grouped into subfamilies in terms of substrate specificity or amino acid sequence. (from Swiss-Prot Q00306, OMIM 603156, and NCI)"                                                                                                                                                                                                                                                                                                                                                         
[20076] "Homolog of mouse Ptk3, human DDR1 Gene (Insulin Receptor Family) at 6p21.3, near D6S478 and HLA class I genes, is composed of seventeen exons spanning 9 kb; expression is activated by p53. Alternative isoforms CAK I and II differ by 37 residues. Type I membrane protein DDR1 expression occurs in kidney, lung, GI tract, and brain epithelia. DDR1 exhibits extracellular Discoidin I motifs; putative ligand-binding GLY/PRO-rich domains; a F5/8 type C domain; and a N-terminal factor VIII-like domain. The C-terminal catalytic domain has type II receptor tyrosine kinase motifs. Neurotrophin TRKs 1-3 regulate development and survival of specific neuronal lineages. Activated by type I-VI collagens, NTRK4 may be a non-neuronal receptor for a NGF or involved in cell-cell interactions or cell adhesion. DDR1 is over-expressed in breast, ovarian, esophageal, and pediatric brain tumors. (from Swiss-Prot Q08345 and NCI)"                                                
[20077] "Tyrosine kinase receptors (TRKs) are a family of genes encoding neurotrophin receptors that include trkA, trkB, and trkC, which are related to development, differentiation, and survival of neural crest-derived neurons and central cholinergic neurons in normal tissue. The genes encoding trkA, trkB, and trkC are designated NTRK1, NTRK2, and NTRK3 and map to chromosomes 1, 9, and 15, respectively. A member of the TRK gene family, trkE, encodes a non-neuronal receptor for nerve growth factor. (from OMIM 600408)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20078] "Similar to murine Cdh3, human CDH3 Gene (CDH Family) at 16q22.1 encodes Placental Cadherin, a homophilic Ca2+-dependent cell-cell adhesion type I membrane glycoprotein. Comprised of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail, the encoded protein may contribute to sorting of heterogeneous cell types. The gene is located in a six-cadherin cluster region involved in loss of heterozygosity in breast and prostate cancer. Aberrant expression is observed in cervical adenocarcinomas. Hypotrichosis with juvenile macular dystrophy is caused by homozygous deletion of an exon 8 guanine nucleotide that introduces a premature downstream termination codon. Mutant expression is reduced in the skin. (from SWISS-PROT P22223, OMIM 114021, and NCI)"                                                                                                                                                                       
[20079] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20080] "Human CDH5 Gene (CDH Family) at 16q22.1 encodes VE-Cadherin, a type I membrane Ca2+-dependent homophilic endothelial cell-cell adhesion glycoprotein. It is comprised of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. Expressed in endothelial cells and brain, CDH5 is found at cell-cell boundaries and probably at cell-matrix boundaries. Associated with intercellular junctions, CDH5 may play an important role in endothelial cell cohesion and organization of intercellular junctions. CDH5/beta-catenin signaling may control endothelial survival. CDH5 associates with alpha-catenin, forming a link to the cytoskeleton. Including CDH1, CDH3, CDH8, and CDH11, CDH5 is located in a six-cadherin cluster region involved in loss of heterozygosity in breast and prostate cancer. (from LocusLink 1003, SWISS-PROT P33151, OMIM 601120, and NCI)"                                                                                  
[20081] "Human putative breast cancer tumor suppressor CDH13 Gene (CDH Family) at 16q24.2-q24.3 encodes Cadherin 13, an 80 kD Ca2+-dependent cell-cell adhesion glycoprotein. Comprised of five extracellular cadherin repeats and attached to the membrane by a GPI-anchor, H-Cadherin lacks the highly conserved cytoplasmic region, unlike typical cadherins. Two alternative polyadenylation mRNAs encode identical proteins. Highest expression is observed in heart. CDH13 is also expressed in CNS; at higher in adult than in developing brain.  A putative mediator of heart cell interactions, this cadherin may also inhibit neural cell growth. CDH13 is expressed in normal cells, but not in most human epithelial tumor cells. The gene is hypermethylated or deleted in breast, ovarian and lung cancers. (from SWISS-PROT P55290, OMIM 601364, LocusLink 1012, and NCI)"                                                                                                                    
[20082] "cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. (LocusLink)"                                                                                                                                                                                     
[20083] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20084] "Cystatin Superfamily Genes comprise a single evolutionary superfamily that encode protein subfamilies with functional and structural similarities that include cystatin-like sequences: Stefins (Type 1 Cystatins), Cystatins (Type 2 Cystatins), and Kininogens. Some members are active cysteine protease inhibitors; others have lost or never acquired inhibitory activity. Cystatins are intracellular or extracellular, tight, reversible, competitive inhibitors of lysosomal cysteine proteinases, such as Cathepsins B, L, H, and S, that appear to provide a protective function. Type 1 Cystatins lack disulfide bridges. Type 2 Cystatins are secreted and have 2 intrachain disulfide bonds. Kininogens contain 3 cystatin-like domains, each with 2 disulfide bonds. (NCI)"                                                                                                                                                                                                           
[20085] "Cystatin Family Genes encode (Type 2) Cystatin proteins, secreted, tight, reversible, competitive inhibitors of cysteine proteinases that contain multiple cystatin-like sequences and have 2 intrachain disulfide bonds. Cystatin Superfamily Genes comprise three subfamilies that display structural and/or functional similarities: Stefins (Type 1 Cystatins), Cystatins (Type 2 Cystatins), and Kininogens. Some members are active cysteine protease inhibitors; others have lost or never acquired inhibitory activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20086] "Human CST6 Gene at 11q13 encodes Cystatin 6, a type 2 cystatin. Cystatin family proteins contain multiple cystatin-like sequences. Three inhibitory subfamilies display structural and functional similarities: type 1 stefins, type 2 cystatins, and kininogens. Some members are active cysteine protease inhibitors; others have lost or never acquired inhibitory activity. Type 2 cystatins are endogenous intracellular or extracellular cysteine proteinase inhibitors that appear to provide a protective function. Cystatin 6 is a novel secreted human cysteine protease inhibitor, down regulated in metastatic breast tumor cells compared to primary tumor cells. Loss of expression is likely associated with primary tumor progression to a metastatic phenotype. (from Swiss-Prot Q15828, OMIM 601891, and NCI)"                                                                                                                                                                    
[20087] "One of three inhibitory families in the cystatin superfamily (including type 2 cystatins and kininogens), Stefin Family Genes (type 1 cystatins) encode intracellular cysteine thiol protease inhibitors of papain and cathepsins B, H, and L. Cystatin Superfamily proteins contain multiple cystatin-like sequences; some are active cysteine protease inhibitors, while others have lost or perhaps never acquired this activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20088] "Encoding Kininogen proteins, Kininogen Family Genes belong to the Cystatin Superfamily, a single evolutionary superfamily of three inhibitory subfamilies that encode proteins with likely protective function and structural similarities that include cystatin-like sequences: Stefins (Type 1 Cystatins), Cystatins (Type 2 Cystatins), and Kininogens. Many members are active cysteine protease inhibitors; others have lost or never acquired inhibitory activity. Kininogens contain 3 cystatin-like domains, each with 2 disulfide bonds. Type 2 Cystatins contain multiple cystatin-like domains and have 2 intrachain disulfide bonds. Type 1 Cystatins contain multiple cystatin-like domains and lack disulfide bridges. (NCI)"                                                                                                                                                                                                                                                         
[20089] "Protein Phosphatase Genes encode Protein Phosphatases, enzymes that remove tyrosine-, serine-, or threonine-bound phosphate groups from many phosphoproteins, including many enzymes phosphorylated by a tyrosine kinase or a serine/threonine kinase. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20090] "Located 100 kb proximal to D17S78 in a 400 kb region containing BRCA1, human DUSP3 Gene at 17q21 is conserved through evolution and encodes VH1-Related Phosphatase, a non-receptor member of the dual specificity protein phosphatase subfamily (Protein Tyrosine Phosphatase Family) expressed in breast and ovarian tissue. The protein inactivates target substrates by dephosphorylating phosphotyrosine and phosphoserine/threonine residues. Negative regulators of MAPK/ERKs, SAPK/JNKs, and p38s associated with proliferation and differentiation, dual specificity phosphatases show different tissue distributions and subcellular locations, distinct MAP kinase specificities, and different modes of induction by extracellular stimuli. (from LocusLink 1845, Swiss-Prot P51452, OMIM 600183, and NCI)"                                                                                                                                                                             
[20091] "These genes encode the intracellular fatty acid-binding proteins (FABPs). Fatty acid metabolism in mammalian cells depends on a flux of fatty acids, between the plasma membrane and mitochondria or peroxisomes for beta-oxidation, and between other cellular organelles for lipid synthesis. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and at least 3 different FABPs play a role as transport vehicles of these hydrophobic compounds throughout the cytoplasm. They may participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. (from LocusLink 2170)"                                                                                                                                                                                                                    
[20092] "Human FABP3 Gene (FABP/P2/CRBP/CRABP Transporter Family), an open reading frame of 399 nucleotides in four exons over 8 kb at 1p33-p31, encodes a 14-15 kD Fatty Acid-Binding Protein 3 of 133 amino acids. Cytoplasmic FABPs in liver, heart, intestine, skeletal muscle, and brain transport intracellular hydrophobic compounds involved in uptake, metabolism, or transport of long-chain fatty acids and their acyl-CoA esters. Mammalian fatty acid metabolism depends on fatty acid flux between plasma membrane and mitochondria or peroxisomes for beta-oxidation and between other cellular organelles for lipid synthesis. A candidate tumor suppressor for human breast cancer, FABP3 is likely involved in intracellular fatty acid transport, arrests the growth of mammary epithelial cells, and is involved in mammary gland differentiation. (from LocusLink 2170, Swiss-Prot P05413, OMIM 134651, and NCI)"                                                                       
[20093] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20094] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20095] "Any subcellular or molecular event, process, or condition involved in translocation of a lipid macromolecule from one site or compartment to another. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20096] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20097] "Any type of motility of a tumor cell that involves translocation of the cell, or cell body, from one site to another; distinct from forms of cell movement that involve only movement of cell processes (e.g., axons, microvilli, etc.). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20098] "Human FGFR4 Gene (FGFR Family) at 5q35.1-qter, distal to DRD1, spans 11 kb with a TATA-free promoter and eighteen exons (17-600 base pairs), and encodes a type I membrane tyrosine kinase Fibroblast Growth Factor Receptor 4. Exon 1 is untranslated and short tandem repeats occur in introns 2 and 16. Highly conserved FGFR4 protein exhibits three extracellular Ig-like C2-type domains, a cytoplasmic kinase domain, and 55% amino acid identity with FLG (FGFR1) and BEK. The FGFR4 IgIII domain C-terminal half does not vary. Affecting downstream mitogenesis and differentiation cascades, FGFR members differ in ligand affinities and distribution; FGFR4 is expressed predominantly in lung. The endoderm selectively co-expresses FGFR1 and FGFR4. Although its function is unknown, FGFR4 binds acidic FGF and FGF19; it does not bind to bFGF. (from LocusLink 2264, Swiss-Prot P22455, OMIM 134935, and NCI)"                                                                   
[20099] "A gene that encodes a protein with a chief function as part of a physical structure within a cell.  This is in contrast to genes that encode proteins with a function that is enzymatic or regulatory."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20100] "Cytoskeletal Genes encode Cytoskeletal Proteins, diverse structural proteins including polymerizable globular subunits (actin, tubulin), \"motor ATPases\" (myosin, dynein), membrane-supporting linkers (spectrin, clathrin), fibrous proteins (keratin, vimentin), and many more. As constituents of the cytoskeleton, Cytoskeletal Proteins form a flexible cellular framework that provides attachment points for organelles and formed bodies and makes communication between cell parts possible. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20101] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20102] "The GAS2 gene encodes a 36-kD protein that is a component of the microfilament system. GAS2 is specifically expressed at growth arrest. When expressed in mammalian cells, the human GAS2 protein is localized at the actin cytoskeleton, along the stress fibers and at the plasma membrane. GS2 is phosphorylated on serine residues during the G0-G1 transition phase. When hyperphosphorylated, GAS2 is accumulates at membrane ruffles. GAS2 plays a role in apoptosis by acting as a cell death substrate for caspases. GAS2 is proteolytically cleaved in apoptotic cells during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. GAS2 is ubiquitously expressed with highest levels in liver, lung, and kidney, but not found in spleen. The GAS2 gene is located at chromosome 11p15.2-p14.3 on the short arm of chromosome 11. (from OMIM 602835, Swiss-Prot O43903)"                      
[20103] "Intracellular or extracellular processes that control, manage, or govern adoption or maintenance of sustained or transient changes in cell shape. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20104] "(mas-TEK-toe-mee) The removal of a cancer as well as some of the breast tissue around the tumor and the lining over the chest muscles below the tumor. Usually some of the lymph nodes under the arm are also taken out.  Also called partial mastectomy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20105] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20106] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20107] "Human GAS8 Gene at 16q24.3 contains eleven exons spanning 25 kb that include a 1.4 kb open reading frame encoding Growth Arrest-Specific Protein 8, a 478-amino acid putative tumor suppressor protein. Two ubiquitous transcripts of 3.4 and 1.8 kb are seen, while a 7.3 kb transcript is observed in heart and skeletal muscle and a 1.4 kb transcript is observed in skeletal muscle alone. Human GAS8 amino acid sequence is 96% identical to the mouse homolog, expressed during growth arrest; the UTRs differ completely. Intron 2 contains C16ORF3, an intronless gene in the opposite orientation transcribed at low levels. GAS8 maps to a region sometimes deleted in breast and prostrate cancer. (NCI)"                                                                                                                                                                                                                                                                               
[20108] "Human ACRBP Gene (CT family) at 12p13.32 encodes Acrosin Binding Protein, similar to proacrosin binding protein sp32 precursor found in pig, mouse, and guinea pig.  ACRBP mRNA is expressed only in normal testis, but detected in a range of tumor types such as bladder, breast, lung, liver, and colon.  Located in the sperm acrosome, this immunogenic protein may bind to proacrosin to package and condense the zymogen in the acrosomal matrix. (from SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20109] "The AGR2 gene at 7p21.3 encodes Anterior Gradient 2 Homolog (Xenepus Laevis), a soluble, signal peptide containing protein that is 47% identical to the cement gland anterior gradient protein (Xenopus laevis). Strongest expression of the 0.9- and 1.6 kb transcripts are seen in the lung and in all estrogen receptor-positive breast carcinoma lines tested while weaker expression is detected in the pancreas and other tissues. Strong expression is also detected in trachea, stomach, colon, prostate, and small intestine. The AGR2 gene is one of seven known genes that are deleted in Wilms tumor and is a candidate suppressor gene for Wilms tumor. (From OMIM, PMID, Proteome and NCI)"                                                                                                                                                                                                                                                                                           
[20110] "Human ANP32C Gene (PP32 family) on chromosome 4 lacks introns and encodes PP32R1, a product that shares approximately 90% amino acid sequence identity with PP32 and PP32R2.  PP32 is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers.  PP32R1 and PP32R2 are tumorigenic.  Amino acids 150-174 of PP32 are responsible for its tumor suppressor function and are a region of divergence with PP32R1.  Alternative use of PP32, PP32R1, and PP32R2 may modulate the oncogenic potential of human prostate cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                        
[20111] "Human HMMR Gene at 5q33.2 encodes a 477-amino acid cell surface and cytoplasmic Hyaluronan-Mediated Motility Receptor, similar to murine Hmmr. Two alternative isoforms are expressed in normal breast tissue. The 15 kb mouse gene contains at least fourteen exons that produce alternative mRNAs. A subunit of the HARC complex, the hyaluronan receptor is required for cell motility and may regulate ERK activity. Hyaluronan receptors mediate glioma cell migration. Phosphorylation of several proteins, including pp125-FAK, occurs when hyaluronan binds HMMR. FAK phosphorylation is necessary for disassembly of focal contacts and motility. RHAMM is up regulated in response to wound healing. Although no correlation is observed between the level of expression and metastatic or malignant potential, HMMR may be involved in transformation and metastasis. (from Swiss-Prot O75330, OMIM 600936, and NCI)"                                                                    
[20112] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20113] "Human ANP32D Gene (PP32 family) on chromosome 12 lacks introns and encodes PP32R2, a product that shares approximately 90% amino acid sequence identity with PP32 and PP32R1.  PP32 is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers.  PP32R2 and PP32R1 are tumorigenic. Amino acids 150-174 of PP32 are responsible for its tumor suppressor function and are a region of divergence with PP32R1. Alternative use of PP32, PP32R1, and PP32R2 may modulate the oncogenic potential of human prostate cancer.  PP32R2 is expressed in prostate cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                
[20114] "Human APPBP2 Gene on chromosome 17 expresses a ubiquitous 6.5 kb transcript with multiple polyadenylation sites encoding 70 kD cytoplasmic Amyloid Beta Precursor Protein-Binding Protein 2. APPBP2 contains terminal globular structures, a coiled coil domain, PKC phosphorylation sites, and four imperfect C-terminal tandem repeats. In the Golgi apparatus, APPBP2 is associated with transport or processing of the signal-transducing amyloid precursor protein (APP). Cell surface sorting of APP depends on a tyrosine-based cytoplasmic basolateral sorting signal (BaSS) sequence to which APPBP2 specifically binds. Amyloid BaSS tyrosine mutation prevents APPBP2 binding and results in nonpolarized transport. Similar to the kinesin light chain, APPBP2 also interacts with microtubules and may have a role in vesicle sorting.  (from OMIM , Proteome, and NCI)"                                                                                                               
[20115] "Human ARHI Gene (RHO family) at 1p31 contains two exons that encode a 1.9 kb transcript expressed in breast and ovarian epithelial cells, and in heart, liver, pancreas, and brain; expression is absent in breast and ovarian cancer cell lines.  Maternally imprinted ARHI is expressed monoallelically and associated with growth suppression; it appears to be a tumor suppressor gene.  Growth factors decrease expression of ARHI, as does WAF1 (CDKN1A).  The 26 kD 229 amino acid RHO-Related GTP-Binding Protein RHOI shares 54% amino acid homology with HRAS and 56-62% homology with RAS-related proteins.  ARHI contains a highly conserved GTP-binding domain, a putative effector domain distinct from that of RAS and RAP proteins, and a C-terminal membrane localization motif.  (from SWISS-PROT, OMIM, Proteome, and NCI)"                                                                                                                                                      
[20116] "Metastasis Suppressor Genes encode Metastasis Suppressors, proteins involved in inhibition of tumor cell metastasis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20117] "Single copy, 25 kb human AXIN2 Gene at 17q24 contains ten exons encoding a 3.0 kb transcript translated into ubiquitous cytoplasmic Conductin, a beta-catenin protein stability regulator inhibiting the WNT pathway. AXIN2 contains DIX, RGS-signaling, GSK-binding, beta-catenin-binding, and DSH domains.  Mouse conductin organizes an APC/beta-catenin/GSK3B complex that promotes beta-catenin degradation. Conductin may facilitate phosphorylation of APC and beta-catenin by GSK3B. Armadillo repeats mediate interaction with beta-catenin. GSK3B may phosphorylate AXIN2, likely dephosphorylated by PP2A. Colorectal cancer associated with MMR gene alterations result in AXIN2 mutations, stabilization of beta-catenin, and activation of beta-catenin/TCF signaling. (from SWISS-PROT, OMIM, Proteome, and NCI)"                                                                                                                                                                    
[20118] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20119] "Human KISS1 Gene at 1q32 encodes a 145-amino acid KISS1 Metastasis Suppressor Protein that may regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization.  KISS1 is expressed as a 1 kb mRNA in normal placenta tissue and as smaller transcripts at low levels in pancreas and kidney.  KISS1 may suppress metastasis without affecting tumorigenicity.  Placental Metastin, a truncated C-terminally amidated peptide form of KISS1, with 54 amino acid residues, is an endogenous ligand of orphan GPR54 (a GPCR) and appears to inhibit chemotaxis and metastasis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                               
[20120] "Human BAP1 Gene at 3p21.3 is ubiquitously expressed as a 4 kb mRNA; plus a 4.8 kb transcript in the testis. The encoded 729-amino acid nuclear BRCA1 Associated Protein-1 contains an acidic region, a highly charged C-terminus, and putative nuclear localization signals. The N-terminus shows homology to ubiquitin C-terminal hydrolases, thiol proteases that catalyze ubiquitin proteolytic processing. Murine BAP1 and BRCA1 are co-expressed during breast development and remodeling. BAP1 interacts with the BRCA1 RING finger, prevented by RING finger germline mutations. BAP1 may be a tumor suppressor in the BRCA1 growth control pathway and enhances BRCA1 inhibition of breast cancer cell growth.  Homozygous BAP1 intragenic rearrangements and deletions occur in lung carcinoma. (from SWISS-PROT, OMIM, Proteome, and NCI)"                                                                                                                                                
[20121] "Ubiquitously expressed 25 kb human BCAR1 Gene (CAS Family) at 16q23.1 contains multiple 5-prime CpG islands and seven exons encoding a 3.2 kb transcript for a 116 kD 870-amino acid p130CAS docking/adaptor molecule. CAS contains a Ser-region, a NH-SH3 domain, a central YXXP motif SH2-binding site substrate domain, SRC SH3-binding site COOH Pro-rich binding region, and C-terminal HLH. CAS functions in embryogenesis, cardiovascular development, actin assembly, and cytoskeletal organization. CAS is tyrosine-phosphorylated in SRC-activated cells and involved in cell adhesion, cell migration, growth factor stimulation, and cytokine receptor engagement. CAS and FAK may function in actin assembly and growth from focal adhesions. CAS over expression confers anti-estrogen resistance to breast cancer cells. (from SWISS-PROT, OMIM, Proteome, and NCI)"                                                                                                                 
[20122] "Subcellular biological functions, activities, or processes that generate, maintain, or modify macromolecular cytoskeletal components. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20123] "Alteration of human BCAR2 Gene, which encodes a protein similar to gamma-butyrobetaine 2-oxoglutarate dioxygenase (C. elegans, Drosophila), is likely responsible for development of an anti-estrogen-resistant phenotype. (from Int J Cancer. 1997; 72:700, LocusLink, GeneCard, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20124] "Human BCAR3 Gene encodes a 92 kD 825-amino acid protein that contains a putative SH2 domain, a hallmark of tyrosine kinase signaling molecules, and sequences homologous to CDC48 (Yeast).  Abundant expression of a 3.4 kb transcript is seen in heart, placenta, skeletal muscle, spleen, prostate, testis, ovary, small intestine, colon, fetal kidney, and several cancer cell lines, but not in nonmalignant breast tissue.  A 6 kb transcript is also detected in skeletal muscle and heart.  NSP2 induces anti-estrogen resistance in estrogen-dependent breast tumors.  (from SWISS-PROT, OMIM, Proteome, and NCI)"                                                                                                                                                                                                                                                                                                                                                                         
[20125] "Human BCAS1 Gene at 20q13.2 encodes a predicted 585 amino acid protein with no significant homology to other proteins and of unknown function that is over expressed in most but not all breast cancer cell lines in which the gene is amplified.  Region 20q13 is amplified in a variety of tumor types and is associated with more aggressive tumor phenotypes.  However, the BCAS1 gene is not located within the common region of maximal amplification in 20q13 and its expression is not detected in the breast cancer cell line MCF7, in which this region is highly amplified.  Although not consistently expressed in breast cancer cell lines, BCAS1 is a candidate oncogene.  (from SWISS-PROT, OMIM, Proteome, and NCI)"                                                                                                                                                                                                                                                                
[20126] "Human BCAS2 Gene at 1p21-p13.3 encodes a 225 amino acid protein that contains a central putative N-glycosylation site and multiple N-terminal putative phosphorylation sites.  BCAS2 is ubiquitously expressed in normal tissues; a 1.5 kb transcript is expressed in many breast cancer cell lines, with greatest amplification in BT-20 and MCF-7 cells.  A sequence identical to BCAS2 is seen in Putative Spliceosome-Associated Protein SPF27.  (from OMIM, Proteome, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20127] "Human BCAS3 Gene at 17q23 encodes a protein of unknown function.  (from SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20128] "Associated with markers RH65330 and SHGC-64933, human BCAS4 Gene at 20q13.13 encodes a protein of unknown function with high similarity to a region of MAP4K1 and similarity to metalloendopeptidase (Drosophila).  Spanning more than 81 kb, BCAS4 is expressed in brain, heart, liver, pancreas, prostate, kidney, and lung.  (from SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20129] "A yet uncharacterized human gene of unknown function, on chromosome 13, and associated with breast cancer. (from LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20130] "Defined by D17S926, D17S695, and D17S849, which map close together in a region of high loss of heterozygosity (60%), human BCPR Gene at 17p13.3 appears to be associated with over expression of p53 mRNA, suggesting a gene located some twenty megabases telomeric to TP53 that regulates its expression.  Lesions of this regulatory gene seem to be involved in most breast cancers. (from OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20131] "Human BC-2 Gene at 19q encodes a protein of unknown function with low similarity to Vps24p (S. cerevisiae). (from SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20132] "A yet uncharacterized human gene at 13q21 of unknown function and associated with breast cancer. (from LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20133] "Spanning more than 10 kb and expressed in breast and testis, human Breast Cancer Antigen NY-BR-1 Gene at 10q11-p12 is composed of thirty-seven exons that encode an open reading frame of 4.0-4.2 kb.  The 150-160 kD NY-BR-1 Protein contains a DNA-binding bZIP motif and five tandem ankyrin repeats.  These structural features of NY-BR-1 imply a transcription factor involved in protein-protein interactions.  (from Cancer Res 2001; 61:2055, SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20134] "BRMS1 is a human breast carcinoma metastasis suppressor gene that maps to 11q13, a hotspot in breast cancer progression.[supplied by OMIM] (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20135] "Human COX7A2L Gene (COXVIIA family) on chromosome 2 encodes a deduced 114 amino acid COX7A-Related Protein that is homologous to mouse Sig81 and contains C-terminal residues similar to polypeptides 1 and 2 of cytochrome c oxidase subunit VIIa.  Ubiquitous expression of a 1.5 kb transcript is enhanced by estrogen through a COX7A2L gene enhancer estrogen-responsive element in a CpG island.  This gene may encode a regulatory subunit of mitochondrial COX that mediates higher energy production in estrogen target cells.  (from SWISS-PROT, OMIM, Proteome, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                
[20136] "Human DLC1 Gene at 8p22-p21.3 is deleted in hepatocellular carcinoma, and frequently in solid tumors.  A major 7.5- and a minor 4.5 kb transcript are widely expressed that encode a deduced 1,091 amino acid protein having high sequence similarity with p122RhoGap (Rat).  DLC1 is a candidate tumor suppressor gene for liver, prostate, lung, colorectal, and breast cancers. (from OMIM, Proteome, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20137] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20138] "Spanning more than 10 kb and expressed in prostate, kidney, and lung, human EPSTI1 Gene at 13q13.3 encodes a protein with putative epithelial stromal interaction function.  EPSTI1 is similar to G-protein coupled receptors family 1 (C. elegans) and G-protein coupled receptor protein signaling pathway growth hormone-releasing hormone receptor (Drosophila).  (from GeneCard, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20139] "The FBXW7 gene (F-Box family) on chromosome 4 encodes splice variants of alpha and beta AGO Protein. These isoforms differ only in their N-termini and contain the putative functional F box and seven WD repeats. F-box proteins (Fbws, Fbls, and Fbxs subclasses) constitute one of four SCF subunits of the ubiquitin protein ligase complex, involved in phosphorylation-dependent ubiquitination. The protein encoded by this gene belongs to the Fbws subclass, binds directly to cyclin E, and probably targets cyclin E for ubiquitin-mediated degradation. Expressed in nonproliferating cells of most or all tissues, CDC4 has a 110 kD and a 69 kD isoform.  AGO mutant cells have elevated levels of cyclin E protein without increased cyclin E mRNA levels.  This gene may represent an important mutational target in ovarian cancer. (from OMIM, Proteome, and NCI)"                                                                                                                
[20140] "Human GA Gene on chromosome 12 encodes a deduced 602 amino acid Glutaminase with a putative N-terminal mitochondrial import presequence.  A 2.4 kb transcript exists in liver, brain, and pancreas, but not in kidney, heart, skeletal muscle, lung, or placenta.  The GA protein shares 94% and 72% sequence identity with rat liver and kidney glutaminases, respectively.  Human glutaminase is most similar to rat liver-type glutaminase, but is not liver specific.  Glutaminase activity and mRNA expression levels depend on cell proliferation state with highest levels at the beginning of the exponential growth phase. (NCI)"                                                                                                                                                                                                                                                                                                                                                          
[20141] "Strongly expressed in testis and placenta, human GAGED3 Gene (GAGE Family) at Xp11.21-p11.22 encodes 111-aa 12-kD GAGED3 Protein, of unknown function and similar to other GAGE/PAGE proteins, as well as to Pyridoxal-Dependent Decarboxylase Conserved Domain (C. elegans) and Larval Locomotory Behavior Glutamate Decarboxylase (Drosophila). GAGE-like genes contain a secondary open reading frame, coding for putative homologues of XAGE-1 protein. GAGED3 also belongs to the CT Family. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20142] "The A2 gene (CLCA family) at 1p31-p22 produces a 3.6 kb transcript in trachea and mammary gland, in addition to lung. The encoded Calcium-Activated Chloride Channel-2 is 51% identical to human CLCA1 and displays an outward rectifying conductance of anions. CLCA2 may be expressed as a 120 kD primary translation product cleaved into an 86 kD N-terminal polypeptide and a 34 kD C-terminal polypeptide, both associated with the cell surface. Expressed predominantly in trachea and lung, calcium-activated chloride channel-2 may play a role in the pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization. CLCA2 has also been implicated as a tumor suppressor gene for breast cancer. (from SWISS-PROT, OMIM, Proteome, and NCI)"                                                                                                                                                     
[20143] "Highly expressed in secretory tissues (liver and pancreas) and induced by hypoxic stress, human HYOU1 Gene (HSP70 Family) at 11q23.1-q23.3 encodes 999-aa (precursor) 150 kD Hypoxia Up-Regulated 1 Protein, an endoplasmic reticulum cytoprotectant in oxygen deprivation that may act as a chaperone with GRPs and participate in protein folding and secretion. ORP150 contains a C-terminal KNDEL sequence and N-terminal similarity to HSP70 ATPase domain. ORP150 suppression is associated with accelerated apoptosis. ORP150 expression in neurons suppresses caspase-3-like activity and enhances BDNF under hypoxia signaling. Elimination of the signal peptide through an alternative translation site may generate a cytosolic housekeeping protein. (NCI)"                                                                                                                                                                                                                            
[20144] "ADAMs (A Disintegrin and Metalloproteinase Domain) are membrane-anchored proteases that regulate cell behavior by proteolytically modifying the cell surface and extracellular matrix. Currently, the ADAM family has 29 members, although the function of most ADAM gene products is unknown. The ADAM gene products with known functions act in a highly diverse set of biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-alpha release and the inflammatory response. (from J Cell Biol 2002;159:893-902 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20145] "Human ADAM11 Gene (ADAM Family, Peptidase M12b Family) at 17q21.3 consists of twenty-eight exons spanning at least 23 kb that encode Disintegrin and Metalloprotease (ADAM) Domain 11, a type I membrane protein. Alternative splicing generates two transcripts that encode MDC-769 and MDC-524. Implicated in cell-cell/-matrix interactions of muscle development, neurogenesis, and fertilization, membrane-anchored ADAM zinc metalloproteases contain disintegrin domains related to snake venom disintegrins. A putative integrin ligand, ADAM11 is a metalloprotease-like noncatalytic protein predominantly expressed in brain that contains an EGF-like domain and a conserved disintegrin domain AVN(E/D)CD motif. The precursor may be cleaved by a furin endopeptidase. Rearrangements that disrupt the coding region occur in breast and ovarian cancers. (from LocusLink 4185, Swiss-Prot O75078, OMIM 155120, and NCI)"                                                             
[20146] "Tightly linked to IL10, IL19, and IL20 within a 195 kb region (IL10 family cytokine cluster), human IL24 Gene (IL10 family) at 1q32 encompasses seven exons that encode secreted Interleukin 24 Protein consisting of 206 amino acids with a predicted size of 23.8 kD.  IL24 appears to represent a differentiation-, growth-, and apoptosis-associated gene.  Expression of IL24 is growth inhibitory toward diverse human tumor cells and may contribute to terminal cell differentiation.  IL24 protein selectively induces p53 independent apoptosis in breast carcinoma cells and inhibits tumor growth in nude mice.  IL24 is up regulated and antiproliferative, or a negative regulator of progression, in human melonoma cells induced to terminally differentiate.  The IL24 gene may have utility for gene-based therapy of diverse human cancers.  (from SWISS-PROT, OMIM, Proteome, and NCI)"                                                                                         
[20147] "Ubiquitously expressed and spanning more than 49 kb, human MLN51 Gene at 17q11-q21.3 encodes a cytoplasmic MLN51 Protein containing 703 residues that shares no significant homology to any known protein.  MLN51 is well conserved between vertebrate and invertebrate species suggesting an important function.  The N-terminal half contains putative nuclear localization signals and a coiled-coil domain that seems to promote MLN51 oligomerization.  The C-terminal half contains a SH2 and four SH3 binding motifs.  The carboxy terminus may regulate localization of the protein to the nucleus.  The unusual combination of protein-protein interaction domains in MLN51 suggests a possible nucleo-cytoplasmic function.  Malignant epithelial cells in breast carcinomas show over expression of MLN51. (from Oncogene 2002; 21:4422, SWISS-PROT, LocusLink, and NCI)"                                                                                                                
[20148] "Spanning more than 13 kb, human NY-BR-20 Gene at 15q22.2 encodes a protein of unknown function.  (from SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20149] "Spanning more than 15 kb, the widely expressed human NY-BR-84 Gene at 20pter-q12 encodes a protein of unknown function similar to acyl-CoA thioesterase (C. elegans) and serologically defined breast cancer antigen 84 (Mouse). (from SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20150] "Spanning more than 9 kb, human OBTP Gene at 6p21.31 encodes Over-Expressed Breast Tumor Protein, which contains two LIM domains and may mediate protein-protein interactions.  (from SWISS-PROT, Proteome, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20151] "This gene is one of several located on tumor-suppressing subtransferable fragments from the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4 (TSSC4), escapes imprinting. This gene may play a role in malignancies and disease that involve this region as well as hematopoietic cell function. This gene is described as a member of the tetraspanin superfamily. (from LocusLink)"                                                                                                                                                                                                                                              
[20152] "Human RBBP1L1 Gene at 1q42.1-q43 encodes RBP1-Like Protein, similar to RBP1, containing a Tudor domain and an ARID DNA binding domain.  Alternatively spliced transcript variants encoding different protein isoforms are thought to exist, but all have not been fully determined.  Transcript variants utilizing alternative polyA sites have also been observed.  Transcript variant 1 encodes a full-length RBP1-like protein isoform 1.  Lacking exon 18, variant 2 encodes a shorter isoform 2 that lacks an internal protein fragment.  (from SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                               
[20153] "Expressed only in mammary and salivary glands, human Small Breast Epithelial Mucin Gene at 12q spans more than 3.7 kb and is predicted to encode a putative low molecular weight secreted sialoglycoprotein, potentially useful for the diagnosis of metastatic breast cancer.  (from Cancer Res 2002; 62:2736, SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20154] "Cell culture studies demonstrate that TACC2 interacts with GAS41 and the SWI/SNF chromatin remodeling complex. This suggests that defects in TACC2 expression may affect gene regulation, thus contributing to the pathogenesis of some tumors. (from Genomics 2003;81:192-201)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20155] "The 5.5 kb human TRAF4 Gene consists of seven exons and encodes a predicted 470 amino acid TNF Receptor-Associated Factor 4 Protein that has an unusual N-terminal RING-type zinc finger motif, a more central cysteine-rich domain containing a CART motif, and a C terminal TRAF domain.  TRAF4 is a member of a family of proteins that interact with TNF receptors and appears to be involved in TNF-related cytokine signal transduction. (from SWISS-PROT, OMIM, Proteome, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20156] "Expressed as a 1.6 kb transcript in fetal brain, lung, liver, and kidney, the human TSSC4 gene at 11p15.5 encodes a protein that shows no close similarity to previously reported proteins. TSSC4 is located in an important tumor-suppressor gene region spanning approximately 1 Mb and containing seven imprinted genes: IGF2, H19, ASCL2, KCNQ1, CDKN1C, TSSC5, and TSSC3. Except for IGF2, each gene is expressed from the maternal allele. A 2.5 Mb STF with proximal D11S12 and distal D11S1318 markers contains the imprinted gene cluster and suppresses growth of the rhabdomyosarcoma cell line RD. In the center of the imprinted gene cluster, TSSC4 and PHEMX genes are not imprinted in any fetal or extraembryonic tissues examined. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, as well as lung, ovarian, and breast cancer. (from SWISS-PROT, OMIM, and NCI)"                      
[20157] "Human MSMB Gene (Ig Binding Factor Family, Beta-Microseminoprotein Family) at 10q11.2 encodes secreted Beta-Microseminoprotein isoforms PSP94 and PSP57 in alternative transcripts. Alternate polyadenylation sites are also found. Strongly expressed in prostate, liver, kidney, breast, and penis, Beta-Microseminoprotein is also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands, and fallopian tube. PSP94 is also expressed in lung and breast, while PSP57 is found in kidney and bladder. Specific receptors are found on spermatozoa and in the prostate. The protein has inhibin-like activity; it may have an autocrine paracrine role in uterine, breast, and other female reproductive tissues. It inhibits pituitary secretion of FSH. MSMB protein expression is decreased in prostate cancer. (from Swiss-Prot P08118, OMIM 157145, and NCI)"                                                                                           
[20158] "The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20159] "Containing seven exons, human WFDC1 Gene (WAP family) at 16q24.3 encodes a deduced 220 amino acid secretory Prostate Stromal Protein ps20, a growth inhibitor that contains a WAP four-disulfide core domain characteristic of protease inhibitors.  The WAP signature motif contains eight cysteines forming four disulfide bonds at the core of proteins that functions as a protease inhibitor in many family members.  Human ps20 shares approximately 86% and 88% identity with rat and mouse proteins, secreted growth inhibitors.  The candidate tumor suppressor WFDC1 gene is located less than 2 Mb from the telomere in an area of frequent loss of heterozygosity in prostate, breast, and hepatocellular cancers and in Wilms' tumor. (from SWISS-PROT, OMIM, Proteome, and NCI)"                                                                                                                                                                                                      
[20160] "The WNT4 gene (WNT family) at 1p35 encodes WNT4 Protein, a cysteine-rich glycoprotein ligand for seven transmembrane frizzled receptors and a putative secreted paracrine signaling molecule that influences the sex-determination cascade. Wnt4 transcripts are detected in brain, lung, and kidney mesenchyme. Ureteric bud growth from the Wolffian duct into presumptive kidney mesenchyme initiates kidney development. In response to a ureter signal, mesenchymal cells condense, aggregate, and differentiate into an epithelial tubule, which morphogenetically transforms into the excretory nephron. Wnt4 may be an autoinducer of nephric mesenchyme-to-epithelial transition. WNT4 up regulates DAX1 (antagonizes SRY) controlling female development and preventing testes formation. WNT4 may be associated with abnormal proliferation in breast tissue. (from SWISS-PROT, OMIM, and NCI)"                                                                                          
[20161] "Highly expressed in the placenta, the human ABCG2 gene (ABC family) at 4q22 makes two transcripts differing at the 5-prime end that encode the same protein. The promoter has a CCAAT box but lacks a TATA box. The ATP Binding Cassette Transporter G2 Protein functions as a membrane-associated homodimeric or homooligomeric xenobiotic transporter in multi-drug resistance. ATP-binding cassette membrane transporters comprise one of the largest protein classes known and are involved in trafficking biologic molecules across extra- and intracellular membranes. ABC genes are divided into seven subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White (ABCG). Multidrug-resistant human breast cancer and colon carcinoma cells express an ABCG2 mRNA that confers resistance to mitoxantrone, doxorubicin, and daunorubicin, reduces intracellular anthracycline and daunorubicin accumulation, and causes an ATP-dependent enhancement of rhodamine-123 efflux. (NCI)"       
[20162] "The RAD54L gene encodes RAD54-Like Protein (RAD54L), a protein that belongs to the DEAD-like helicase superfamily. RAD54L plays a role in homologous recombination related repair of DNA double-strand breaks. The binding of RAD54L to double-strand DNA induces a DNA topological change, which facilitates homologous DNA paring and stimulates DNA recombination. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20163] "A product of the PPBP gene, pro-platelet basic protein is processed into platelet basic protein (PBP) and connective-tissue-activating peptide III (CTAP-III).  Upon platelet activation these proteins undergo further processing into beta thromboglobulin (Beta-TG) and neutrophil-activating peptide 2 (NAP2), respectively.  Many of the function ascribed to CTAP-III may actually be the result of processing to NAP-2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20164] "Platelet factor-4 is a 70-amino acid CXC chemokine. It is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20165] "The process of clot formation. (from On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20166] "The RAD51 family of related genes, identified in both yeast and humans, encode strand-transfer proteins thought to be involved in recombinational repair of DNA damage and in meiotic recombination. Several members of the mammalian RAD51 gene family have been identified, for example, RAD51A, RAD51B, XRCC3, DMC1, and RAD51C. (From OMIM 602774)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20167] "Human RAD51C Gene (RECA Family, RAD51 Subfamily) at 17q encodes DNA Repair Protein RAD51 Homolog 3, a probable 376-amino acid nuclear protein likely involved in meiotic recombination and repair of damaged DNA. Three alternative variants have been observed with highest expression in testis, heart muscle, spleen, and prostate. RAD51 family members are strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. RAD51C protein interacts strongly with RAD51B and moderately with XRCC3 DNA repair proteins, but not with itself. The RAD51C/XRCC3 complex binds single-stranded, but not duplex, DNA. (from Swiss-Prot O43502, OMIM 602774, and NCI)"                                                                                                                                                                                                                                                                       
[20168] "Human NOVA1 Gene (NOVA Family) at 14q encodes NOVA-1, a neuron-specific nuclear RNA-binding protein containing three KH domains. Alternative transcript variants differ by a seventy-two base pair exon H, as well as by a nine base pair motif. NOVA-1 may regulate RNA splicing or metabolism in specific developing neurons. Murine Nova1 is expressed in ventral spinal cord, brain stem nuclei, deep cerebellar nuclei, and hypothalamus. It binds RNA in a sequence-specific manner to regulate neuron-specific splicing of inhibitory receptor pre-mRNAs in postnatal motor neurons. Nova1 also specifically binds to the GLRA2 intronic sequence (UCAUY)3. Antibodies against NOVA-1 occur in paraneoplastic opsoclonus-ataxia (POA). (from LocusLink 4857, Swiss-Prot P51513, OMIM 602157, and NCI)"                                                                                                                                                                                       
[20169] "Thioredoxin is an oxidoreductase enzyme of 12,000 daltons, containing a dithiol-disulfide active site. Thioredoxin catalyzes intracellular disulfide reductions but also has cytokine activity with interleukins after leaderless secretion. (from OMIM and COPE)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20170] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20171] "Expressed in brain (neurons or astrocytes), NOVA Family Genes encode NOVA Family nuclear proteins (NOVA1, NOVA2), autoantigens in POMA recognized by IgG ANNA-2 that contain 3 KH domains and may regulate RNA splicing in neurons and astrocytes. NOVA proteins form structural complexes with other proteins. Found as one or multiple copies of a conserved 70-aa motif in diverse nucleic acid binding, and other, proteins, the KH domain binds RNA; each motif appears necessary for binding. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20172] "These genes encode proteins that function in the nuclear transport of protein and RNA. Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. (from LocusLink 4928, OMIM 601021)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20173] "Up regulated by interferon, human NUP98 Gene (GLFG Nucleoporin Family) in an imprinted domain at 11p15 encodes Nucleoporin 98 kD in several alternative variants. Proteolytic cleavage of a 186 kD precursor yields NUP98 and NUP96, both located at the multiprotein nuclear pore complex (NPC) nucleoplasmic side. NUP96 and NUP98 targeting to the NPC is dependent on cleavage. NUP98 may function as a docking protein for import. The C-terminal RNA-binding domain of NUP98 contains NPC target sequences, a novel protein fold, and an autocatalytic protease; docking/transport function is located in the N-terminal GLFG/FXFG repeats. Vesicular Stomatitis Virus M Protein targets NUP98. Translocations in several myeloid leukemias fuse NUP98 to other genes; t(7;11)(p15;p15) generates N-terminal NUP98 fused in-frame to HOXA9. (from LocusLink 4928, Swiss-Prot P52948, OMIM 601021, and NCI)"                                                                                   
[20174] "A health professional trained to care for people who are ill or disabled."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20175] "Licensed Practical Nurse - a professional healthcare provider who has graduated from an accredited licensed practical nursing program, has passed the state exam for licensure, and been licensed to practice by a state authority."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20176] "Research funding program designed to take advantage of high priority reseaarch opportunities that can be completed in short time frames. (2003 Bypass Budget)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20177] "Registered Nurse (R.N.) - a nurse who has graduated from an accredited registered nursing program, has passed the state exam for licensure, and been registered and licensed to practice by a state authority.  R.N.s receive educational preparation through hospital-based diploma programs, community/junior college associate's degree programs, baccalareate programs, or combinations thereof."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20178] "A registered nurse, usually prepared at the master's degree level or higher, who functions within a specialty area within nursing practice.  Advanced practice nurses make independent and collaborative health care decisions. Advanced practice nurses are expert clinicians engaged in active practice. The advanced practice nurse demonstrates leadership as a consultant, educator, administrator and researcher. An important leadership function of all advanced practice nurses is participation in legislative and professional activities to promote professional advancement and health related social policies. (from AANP)"                                                                                                                                                                                                                                                                                                                                                           
[20179] "The use of molecular tools and techniques, especially gene and protein expression profiles, to diagnose disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20180] "Use of optical coherence tomography to capture ulta-high resolution images of tissue surfaces which can be used to identify cancerous legions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20181] "Optical Coherence Tomography (OCT) combines the principles of ultrasound with the imaging performance of a microscope.  OCT uses infrared light waves that reflect off the internal microstructure within the biological tissues. The frequencies and bandwidths of infrared light are orders of magnitude higher than medical ultrasound signals, resulting in greatly increased image resolution, 8-25 times greater than any existing modality. In addition to providing high-level resolutions for the evaluation of microanatomic structures OCT is also able to provide information regarding tissue composition. (from http://www.lightlabimaging.com/oct.html)"                                                                                                                                                                                                                                                                                                                             
[20182] "Preferentially expressed from the maternal chromosome predominantly in fetal and adult liver and kidney as 2 alternative transcripts, 23-kb 11-exon human SLC22A1L Gene (Polyspecific Transporter/MDR Family) in an imprinted gene domain at 11p15.5 encodes 424-aa Tumor Suppressing Subtransferable Candidate 5 Protein (Organic Cation Transporter-Like 2 Protein), a polyspecific organic-cation transporter containing 10 transmembrane segments and involved in excretion of endogenous and exogenous compounds. Divergent SLC22A1L and ORCTL2S genes overlap; ORCTL2S exon 1 shares 31 bp with SLC22A1L exon 2. SLC22A1L translation may begin at the second methionine, which would result in a 408-amino acid protein. (NCI)"                                                                                                                                                                                                                                                              
[20183] "Certified nurse-midwive (CNM) - licensed health care practitioner educated in the two disciplines of nursing and midwifery. CNMs provide primary health care to women of childbearing age including: prenatal care, labor and delivery care, care after birth, gynecological exams, newborn care, assistance with family planning decisions, preconception care, menopausal management and counseling in health maintenance and disease prevention. (ACNM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20184] "Certified Registered Nurse Anesthetist (CRNA) - a registered nurse who provides anesthetics to patients in collaboration with surgeons, anesthesiologists, dentists, podiatrists, and other qualified healthcare professionals.  CRNAs practice with a high level of autonomy in most surgical practice settings. (AANA)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20185] "Clinical Nurse Specialist (CNS) - a licensed registered nurse who has graduate preparation (a master's or a doctorate) in nursing as a CNS.  The CNS is a clinical expert in theory-based and/or research-based nursing practice within a specialty area. (NACNS)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20186] "Cardiac/Vascular nurses provide comprehensive nursing care to individuals diagnosed with cardiac/vascular disease as well as those identified at risk for cardiac/vascular events. These services are provided in a variety of settings including acute and ambulatory care facilities, community-based facilities, and work-site and school-based programs. Cardiac/vascular nursing practice promotes achievement and maintenance of optimal cardiac/vascular wellness.  The cardiac/vascular nurse is responsible for the development, coordination, and evaluation of a plan of care that uses a multi-disciplinary/case management approach. While concentrating on cardiac/vascular health, the practice considers all influences on health status and the related social and behavioral problems. The theoretical basis for this nursing practice incorporates physiological and psychosocial concepts of health as they affect cardiac/vascular wellness. (ANCC)"                           
[20187] "A registered nurse prepared at the master's degree level or higher who specializes in exploring and meeting the needs of select populations in community contexts. (UMD, SON)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20188] "The Advanced Diabetes Management Practitioner has an advanced degree and is able to (1) perform complete and/or focused assessments, (2) recognize and prioritize complex data in order to identify needs of patients with diabetes across the life span, and (3) provide therapeutic problem-solving, counseling, and regimen adjustments.  The scope of advanced diabetes practice includes management skills such as medication adjustment, medical nutrition therapy, exercise planning, counseling for behavior management and psychosocial issues. Attaining optimal metabolic control may include treatment and monitoring of acute and chronic complications.  The depth of knowledge and competence in advanced clinical practice and diabetes skills affords an increased complexity of decision making, which expands the traditional discipline specific practice. Research, publications, mentoring, and continuing professional development are expected skill sets. (ANCC)"          
[20189] "Wound, Ostomy and Continence (WOC) Nurses manage conditions such as stomas, draining wounds, fistulas, vascular ulcers, pressure ulcers, neuropathic wounds, urinary incontinence, fecal incontinence, and functional disorders of the bowel and bladder. (WOCN)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20190] "Clinical specialists in gerontological nursing are experts in providing, directing, and influencing the care of older adults and their families and significant others in a variety of settings. Clinical specialists demonstrate an in-depth understanding of the dynamics of aging, as well as of the interventions necessary for health promotion and management of health status alterations. Clinical specialist provide comprehen-sive gerontological nursing services independently or collaboratively with multidis-ciplinary teams. Through theory and research; clinical specialists advance the health care of older adults and the specialty of gerontological nursing. Clinical specialists are engaged in practice, case management, education, consultation, research, and administration. (ANCC)"                                                                                                                                                                                   
[20191] "Home health nursing refers to the practice of nursing applied to a client with a health deficit in the client's place of residence or appropriate community site. The graduate-prepared clinical specialist in home health nursing can and may be asked to perform all the functions of a generalist. In addition, the clinical specialist possesses substantial clinical experience with clients who are individuals, families, and groups. The clinical specialist has expertise in the process of case management, consultation, collaboration, and education of clients, staff, and other health professionals.  In addition, the clinical specialist has proficiency in planning, implementing, and evaluating programs, resources, services, and research for health care delivery to complex clients. (ANCC)"                                                                                                                                                                                
[20192] "Evolutionarily conserved, ubiquitously expressed human PHB Gene (Prohibitin Family) at 17q21 encodes Prohibitin, a 30 kD cytoplasmic antiproliferative protein that inhibits DNA synthesis, regulates proliferation, and may be a tumor suppressor. Prohibitin is expressed as two transcripts with varying lengths of 3-prime UTR.  The longer transcript is present at higher levels in proliferating cells; the longer 3-prime UTR may act as a trans regulator. The human prohibitin family consists of one functional gene and four processed pseudogenes: PHBP1, PHBP2, PHBP3, and PHBP4. Mutations in PHB have been linked to sporadic breast cancer. (from Swiss-Prot P35232, OMIM 176705, and NCI)"                                                                                                                                                                                                                                                                                        
[20193] "Graduate-prepared clinical specialists in Medical-Surgical Nursing provide care for individuals who have a known or predicted physiological alteration. Clinical specialists demonstrate an in-depth understanding of complex medical-surgical problems, as well as interventions to manage and improve patient care. Guided by theory and research, their practice considers all influences on health status and the related social and behavioral problems arising because of the patient's physiological condition. Clinical specialists are engaged in education, case management, expert clinical practice, consultation, research, and administration. Clinical specialists practice in settings where primary, acute, or long-term nursing care is delivered. (ANCC)"                                                                                                                                                                                                                        
[20194] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20195] "A clinical nurse specialist that provides a high level of supportive and therapeutic care to cancer patients and their families.  The ONS is an excellent resource for current trends in cancer care and therapies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20196] "The clinical specialist in pediatric nursing is a graduate-prepared clinician and child and family advocate. Within the scope of pediatric nursing practice the child and family are considered the client. Clinical specialists demonstrate an in-depth understanding of complex pediatric health care by engaging in education, case management, expert clinical practice, consultation, research and administration.  Change and systems theory are utilized to develop interventions to manage and improve patient care. Clinical specialists in pediatric nursing practice across the trajectory of care in settings which include primary, acute, community, or rehabilitation. (ANCC)"                                                                                                                                                                                                                                                                                                       
[20197] "Nurse educators are registered nurses prepared at the graduate or doctoral level who prepare students for nursing practice at a variety of levels, including entry level, continuing education, advanced practice, and specialty practice.  Nurse educators work in various settings, including colleges/universities, community colleges, hospitals, nursing homes, private practice, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20198] "Ribosome Subunit Genes encode Ribosomal Proteins, present in either the small or the large ribosomal subunit and involved in protein synthesis. In eukaryotes there are 50 proteins in the large subunit and 33 in the small subunit. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20199] "The highly conserved human RPL13 Gene (L13E Ribosomal Protein Family) encodes Ribosomal Protein L13, a cytoplasmic ribosomal 60S subunit protein. One major transcript and variants (alternative splicing or polyadenylation) encode the same protein. Typical of ribosomal protein genes, there are multiple processed genomic pseudogenes. The protein is highly basic with no signal or transmembrane sequence, but it has two potential nuclear localization signals. Ribosomes consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately eighty structurally distinct proteins. (from Swiss-Prot P26373, OMIM 113703, and NCI)"                                                                                                                                                                                                                                                                                       
[20200] "Ribonucleotide Reductase Subunit Genes (RRM1 and RRM2) encode the M1 Chain and M2 Chain subunits of Ribonucleoside-Diphosphate Reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate site and catalytic site regulate enzyme activity. Allosteric control by deoxynucleoside triphosphates and by ATP bound to M1 prevents DNA replication and cell proliferation. An M1 catalytic site only forms in the presence of M2. M2 synthesis is cell-cycle dependent. p53 regulates ribonucleotide reductase by interaction with p53R2 as well as the M2 subunit. (NCI)"                                                                                                                                                                                        
[20201] "The human RRM1 Gene at 11p15.5 encodes Ribonucleoside-Diphosphate Reductase M1 Chain, which is 1 of 2 ribonucleoside-diphosphate reductase subunits, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Complex allosteric control, mediated by deoxynucleoside triphosphates, and by ATP bound to the M1 subunit prevents DNA replication and cell proliferation. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. RRM1 functions as a metastasis suppressor gene through induction of PTEN expression and PTEN-regulated pathways. (from Swiss-Prot, OMIM, LocusLink and NCI)"                                                                           
[20202] "S100 Family Gene members, many clustered on chromosome 1q21, encode S100 Calcium Binding Proteins localized in the cytoplasm and/or nucleus of many cells that often regulate cellular processes such as cell cycle progression and differentiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20203] "Clustered with at least twelve S100 genes, human S100A2 Gene at 1q21 encodes S-100L Protein, a S100 Family EF-hand cell-specific Ca2+-binding protein. S100A1, closest to the telomere, and S100A1 are located within 450 kb; S100A9 is nearest the centromere. Preferentially expressed in mammary epithelia and keratinocytes, DNA methylation may suppress S100A2; expression is induced by growth factors in G1 and by cell-cycle regulation in S phase. Cytoplasmic and nuclear S100 proteins regulate cell cycle progression and differentiation. Containing two EF-hand domains, S-100L Protein interacts with target proteins to link extracellular stimuli to cellular responses and may modulate excess calcium accumulation. S100A2 levels correlate inversely with tumor progression. Chromosomal rearrangements and altered expression of S100A2 have been implicated in breast cancer. (from LocusLink 6273, Swiss-Prot P29034, OMIM 176993, and NCI)"                                
[20204] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20205] "Nurse Practitioner (NP) - A registered nurse (RN) with advanced training in diagnosing and treating illness.  NPs are master's degree prepared health experts that focus on helping patients achieve total health and prevent disease.  NPs focus on disease prevention, wellness, and patient education.  NPs prescribe medications, treat illness, and perform physical examinations.  NPs can function indepent of physician intervention, but require a \"practice agreement\" with a physician."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20206] "Case management includes nursing activities of coordination, advocacy, and referral. These activities involve facilitating service delivery on behalf of the client, communicating with health and human service providers, promoting assertive client communication, and guiding the client toward use of appropriate community resources."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20207] "Professions that require the skills and experiences of nurses, but do not require actual patient contact on a regular basis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20208] "An Informatics Nurse encompasses the full range of activities that focus on the methods and technologies of information handling in nursing. Informatics nursing practice includes the development, support, and evaluation of applications, tools, processes, and structures that assist the practice of nurses with the management of data in direct care of patients/clients. The work of an informatics nurse can involve any and all aspects of information systems, including theory formulation, design, development, marketing, selection, testing, implementation, training, maintenance, evaluation, and enhancement.  Informatics nurses are engaged in clinical practice, education, consultation, research, administration, and pure informatics. (ANCC)."                                                                                                                                                                                                                             
[20209] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20210] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20211] "Highly conserved human SNCG Gene (Synuclein Family) at 10q23.2-q23.3 contains five exons that encode 127-amino acid cytoplasmic Gamma-Synuclein, similar to amyloid protein nonamyloid beta fragment, alpha-synuclein, and beta-synuclein. SNCG is highly expressed in brain; expressed in heart, skeletal muscle, ovary, testis, colon, and spleen; and weakly expressed in pancreas, kidney, and lung. Gamma-Synuclein may modulate axonal architecture and neurofilament integrity. It may promote Ca2+-dependent protease susceptibility of neurofilament-H and modulate the keratin network. GRK5 phosphorylation occurs on residues distinct from other kinase targets. Gamma-Synuclein may be involved in the pathogenesis of neurodegenerative diseases. Protein levels increase in aging cerebral cortex and SNCG is expressed at a high level in advanced infiltrating breast cancer. (from Swiss-Prot O76070, OMIM 602998, and NCI)"                                                     
[20212] "Nurse executives are registered nurses who are instrumental in the design, facilitation, and management of patient care in their respective organizations. They hold titles such as chief nursing officer, nursing director, chief operating officer of health care facilities and systems, nurse manager, consultant in nursing administration and management, dean, and director of faculty in graduate and undergraduate nursing programs. (from AONE)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20213] "Nursing Health Policy Specialists are Registered Nurses academically prepared at the graduate level who analyze, evaluate, and propose public and institutional policy that affects health care availabilty, accessibilty, and delivery within a given population, region, or facility."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20214] "Personnel trained to assist with the direct care of patients in all health settings and in the home.  Unlicensed Assistive Personnel work under the direct supervision of RNs to extend the abilities of the nurse to provide for patients' activities of daily living."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20215] "Located in an imprinted domain, ubiquitously expressed human STIM1 Gene at 11p15.5 is oriented head-to-tail with RRM1; its 3-prime end is 1.6 kb from the RRM1 5-prime end. Similar to the murine gene, STIM1 contains twelve exons over more than 250 kb between RRM1 and NUP98. STIM1 encodes Stromal Interaction Molecule 1 Protein, a potential glycosylated cell surface type 1 transmembrane protein that influences the survival or proliferation of B cell precursors and may act as an adhesion molecule in hematopoiesis by mediating attachment to stromal cells. Phosphorylated mainly on serine residues, the 746-amino acid protein contains a predicted signal peptide, a transmembrane helix, and one SAM domain. STIM1 oligomerizes with STIM2 and cell binding may require Mn(II). Defects in STIM1 may cause rhabdomyosarcoma and rhabdoid tumors. (from LocusLink 6786, Swiss-Prot Q13586, OMIM 605921, and NCI)"                                                               
[20216] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20217] "Located close to FGFR1, human TACC1 Gene (TACC Family) at 8p11 is highly expressed during embryogenesis as a major 8.0 kb transcript in all tissues tested. The 805-amino acid TACC1 Protein is rich in serine, proline, and acidic residues; has a 20-amino acid tryptophan-rich N-terminus; contains two nuclear localization signals, but no DNA- or RNA-binding domains; and has a 200-residue C-terminus with extensive alpha-helical segments expected to adopt a coiled-coil structure. Although the nuclear protein is concentrated at centrosomes and interacts with microtubules and tubulin, its function is not yet determined. TACC1 is a potential breast cancer candidate gene. (from LocusLink 6867, Swiss-Prot O75410, OMIM 605301, and NCI)"                                                                                                                                                                                                                                      
[20218] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20219] "Nursing care provided in an ambulatory setting, such as a clinic or physician's office."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20220] "Cardiac/Vascular nursing is the provision of comprehensive nursing care to individuals diagnosed with cardiac/vascular disease as well as those identified at risk for cardiac/vascular events. These services are provided in a variety of settings including acute and ambulatory care facilities, community-based facilities, and work-site and school-based programs. Cardiac/vascular nursing practice promotes achievement and maintenance of optimal cardiac/vascular wellness.  The cardiac/vascular nurse is responsible for the development, coordination, and evaluation of a plan of care that uses a multi-disciplinary/case management approach. While concentrating on cardiac/vascular health, the practice considers all influences on health status and the related social and behavioral problems. The theoretical basis for this nursing practice incorporates physiological and psychosocial concepts of health as they affect cardiac/vascular wellness. (ANCC)"              
[20221] "Clinical nursing applies the skills and processes of nursing to patients in an acute care environment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20222] "The provision of professional nursing care in an inpatient setting."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20223] "Professional nursing care provided in a long-term care/nursing facility to residents unable to provide for themselves a safe and adequate level of care."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20224] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20225] "Altered expression, deletion, and/or mutations of the TFF1 gene are frequently observed in human gastric carcinomas.  Thus, it has been classified as a gastric tumor suppressor gene.  TFF1 represses cell progression towards the S phase of the cell cycle, and therefore proliferation.  However, TFF1 has a complex role in that it is not only a potent inhibitor of proliferation, but also an efficient inhibitor of apoptosis.  Similar dual and paradoxical functions have already been reported for tumor suppressor genes involved in cell differentiation. (from J Cell Biol 2002;157:761-70)"                                                                                                                                                                                                                                                                                                                                                                                         
[20226] "GPR39 is a single-copy gene, expressed in brain and other peripheral tissues. It encodes a protein with high homology to the growth hormone secretagogue receptor (GHSR), a G protein-coupled receptor found in the pituitary gland and brain that is involved in the control of growth hormone release. The ligand-binding and functional properties of GPR39 remain to be determined. (from OMIM and Genomics 1997;46:426-34)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20227] "Medical-Surgical Nursing includes the provision of care to individuals who have a known or predicted physiological alteration. Working within an interdisciplinary team and guided by theory and research, medical-surgical nursing practice considers all influences on health status and the related social and behavioral problems arising because of the patient's physiological condition.  Medical-surgical nursing is practiced in primary, acute, or long-term nursing care facilities. (from ANCC)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20228] "Nursing care with a special emphasis on the care of individuals with orthopaedic-related injuries, diseases, and diagnoses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20229] "Medical and skilled nursing services provided to patients who are not in an acute phase of an illness but who require a level of care higher than that provided in a long-term care setting. (JCAHO, Lexikon, 1994)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20230] "Professional nursing care provided in a research environment.  Including management of clinical trials, direct patient care, and research assistance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20231] "The provision of emergency or supportive nursing care to patients transported by helicopters or fixed-wing aircraft."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20232] "Nursing care of the surgical patient before, during, and after surgery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20233] "Nursing care of the patient under anesthesia and in the immediate post-anesthesia period."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20234] "The specialty or practice of nursing in the care of patients admitted to the emergency department."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20235] "Critical Care Nursing specialty devoted to the care of the traumatically injured patient."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20236] "Professional nursing care provided within the home of the individual under care."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20237] "Intravenous nursing practice involves all aspects of infusion therapy, including phlebotomy, intravenous peripheral and central access line placement (PICC), chemotherapy, hyperalimentation, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20238] "Nursing care of the newborn infant."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20239] "This gene encodes mesothelin.  Although its function is unknown, it may play a role in cellular adhesion and is present on mesothelium, mesotheliomas, and ovarian cancers. Three transcript variants have been described for this gene and their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. The protein isoform named MPF is a cytokine with megakaryocyte potentiating activity. The soluble member encoded by the third splice variant is detected in ovarian carcinoma; the full length sequence of the third variant has not been described. (LocusLink)"                                                                                                                                                                                                                                                                                                                              
[20240] "An antibody that reacts with ovarian cancers and mesotheliomas was used to isolate a cell surface antigen named mesothelin. Although the function of mesothelin is unknown, it may play a role in cellular adhesion and is present on mesothelium, mesotheliomas, and ovarian cancers. Three transcript variants have been described for this gene and their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. The protein isoform named MPF is a cytokine with megakaryocyte potentiating activity. The soluble member encoded by the third splice variant is detected in ovarian carcinoma; the full length sequence of the third variant has not been described. (LocusLink)"                                                                                                                                                                                                                   
[20241] "Nursing care given to the pregnant patient before, during, or after childbirth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20242] "Nursing specialized in providing palliative care.  It's aim is to provide relief from pain and other symptoms.  This care includes support, counseling, and education for both the patient and their family."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20243] "The nursing care of children from birth to adolescence. It includes the clinical and psychological aspects of nursing care."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20244] "This gene generates 5 alternatively spliced transcript variants, which encode 5 different protein isoforms. These isoforms contain one or two WAP-type four-disulfide core (WFDC) domains, and are thus members of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded isoforms are small secretory proteins, which may be involved in sperm maturation. (LocusLink)"                                                                                                                                                                                                                                                                                                                                    
[20245] "Health and nursing care given to campers at a summer or children's camp by a registered nurse."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20246] "Expressed in several tissues, including male reproductive system, respiratory tract, and nasopharynx as 5 alternatively spliced transcripts, human WFDC2 Gene (WFDC Family) encodes 5 secreted isoforms of Epididymal Secretory Protein E4 that contain one or two WFDC domains. The WFDC domain contains eight cysteines forming four disulfide bonds at the protein core and often functions in protease inhibition. WFDC2 may be involved in sperm maturation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20247] "Nursing care provided for children and adults with developmental disabilities in the homes, schools, and communities to maximize their ability to interact and function in the community at large."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20248] "The application of nursing principles to the study of the patterns of disease or other events across populations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20249] "Nursing care provided to the transplant recipient and donor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20250] "This gene was identified as one of several residing in tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20251] "Human TSSC3 Gene at 11p15.5 is located in a 1 Mb imprinted tumor-suppressor gene domain that includes H19, IGF2, CDKN1C, and KVLQT1. A 170 kb subregion between D11S601 and D11S679 contains NAP2, CDKN1C, KVLQT1, BWR1A, BWR1B, and TSSC3. TSSC3 is located between centromeric NAP2 and telomeric CDKN1C. Like other imprinted genes, TSSC3 is small with small introns; TSSC3 contains a single 223 base pair intron and encodes TSSC3 Protein. TSSC3 is maternally expressed in placenta, liver, fetal and adult liver, lung, and kidney, adult pancreas, and fetal tissues. Similar to TDAG51, essential for FAS expression and apoptosis susceptibility, TSSC3 may also be involved in susceptibility to apoptosis. Mouse Tssc3 encodes a small cytoplasmic protein with a pleckstrin-homology (PH) domain. (from Swiss-Prot O00496, OMIM 602131, and NCI)"                                                                                                                                   
[20252] "Expressed exclusively in epithelial cells, the 6-kb 9-exon human ELF3 Gene (ETS Family) at 1q32.2 encodes E74-Like Factor 3, an ETS domain and A/T hook domain transcriptional activator that regulates expression of epithelial-specific genes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20253] "ESX, a novel member of the ETS transcription factor family, is a tumor marker exclusively expressed in epithelial cells.  ESX contains two putative DNA-binding domains: an ETS domain and an A/T hook domain. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20254] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20255] "This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20256] "A wingless (Drosophila) homolog, human WNT3 Gene (WNT Family) at 17q21 is clustered with WNT15 and encodes WNT-3 Protein, with 98% amino acid identity to mouse Wnt3 and 84% to human WNT3A. Comparison to mouse protein sequence shows four changes in 333 amino acids. Highly-conserved structurally related WNT genes encode 350-400 amino acid, cysteine-rich, putative paracrine signaling glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. Wnt3 is required in mouse primary axis formation and ectodermal anterior-posterior neural patterning. WNT3 may play a role in some cancers through activation of the WNT-beta-catenin-TCF signaling pathway. (from LocusLink 7473, Swiss-Prot P56703, OMIM 165330, and NCI)"                                                                                                        
[20257] "The sodium-iodide symporter (NIS), a member of the sodium/solute symporter family, actively transports iodide across the basolateral plasma membrane of the thyroid follicular cells. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20258] "Clustered head-to-head with WNT1 in a 7 kb interval, human WNT10B Gene (WNT Family) at 12q13 encodes a 389-amino acid WNT-10B Protein in five exons. WNT1-WNT10B may have derived from duplication. Highly-conserved structurally related WNT genes encode 350-400 amino acid, cysteine-rich, putative paracrine signaling glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning and cell growth or differentiation in some adult mammalian tissues. WNT10B expression is highest in heart and skeletal muscle; low levels are found in. WNT10B nucleotide sequence is 96% identical to murine Wnt10b. WNT10B appears to maintain undifferentiated preadipocytes by inhibition of CEBPA and PPAR-gamma. Axin blockage of WNT signaling induces adipocyte differentiation. (from LocusLink 7480, Swiss-Prot O00744, OMIM 601906, and NCI)"                                                                             
[20259] "The production of fat, either fatty degeneration or fatty infiltration; also applied to the normal deposition of fat or to the conversion of carbohydrate or protein to fat. (On-Line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20260] "Human CCL2 Gene encodes Small Inducible Cytokine A2, a chemotactic chemokine for monocytes and basophils, but not neutrophils or eosinophils, produced by monocytic and lymphocytic leukocytes and by fibroblasts during tissue injury that binds to chemokine receptors CCR2 and CCR4. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20261] "Within 300 kb of MPO, human ZNF147 Gene (TRIM Family, RING Finger Family) at 17q23.1 encodes a ubiquitous cytoplasmic estrogen-responsive Zinc Finger Protein 147. Gene expression is up regulated via a 3-prime UTR ERE. Putative DNA-binding and dimerization-transactivation domains suggest ZNF147 to be a transcription factor, similar to other TRIM family members. The TRIM motif includes three zinc-binding domains, a SPRY domain, a RING, a B-Box Type 1 and Type 2, and a coiled-coil region. Zinc Finger Protein 147 is a RING-finger-dependent ubiquitin ligase (E3) that targets proteolysis of 14-3-3-sigma, a negative cell cycle regulator that causes G2 arrest. Lack of EFP function results in 14-3-3-sigma accumulation; 14-3-3-sigma is a target for proteolysis by EFP, leading to cell proliferation. (from LocusLink 7706, Swiss-Prot Q14258, OMIM 600453, and NCI)"                                                                                                     
[20262] "A chemokine that is a chemoattractant for human monocytes and may also cause cellular activation of specific functions related to host defense. It is produced by leukocytes of both monocyte and lymphocyte lineage and by fibroblasts during tissue injury. (MeSH Definition)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20263] "Associated with cell survival and expressed in fibroblasts (high), heart, kidney, lung, pancreas, placenta, ovary, small intestine, and spleen by human WISP1 Gene (WISP/CCN/CTGF Family), 367-aa 40-kDa (precursor) and 280-aa isoforms of secreted WNT1 Inducible Signaling Pathway Protein 1 contain 4 conserved Cys-rich domains: a IGFBP domain, a VWFC domain, a TSP type-1 domain, and a CTCK domain. WISP1 up-regulates anti-apoptotic BCL-X(L) protein and attenuates p53-mediated apoptosis induced by DNA damage through activation of AKT kinase. WISP1 binds to, and may prevent the anti-proliferation activity of, decorin and biglycan, small leucine-rich connective tissue extracellular matrix proteoglycans. WISP1 may act as a downstream regulator in the WNT/Frizzled signaling pathway. (NCI)"                                                                                                                                                                              
[20264] "Associated with cell survival and expressed in fibroblasts (high), heart, kidney, lung, pancreas, placenta, ovary, small intestine, and spleen, human WISP1 Gene (WISP/CCN/CTGF Family) encodes alternative, 367-aa 40-kDa (precursor) and 280-aa, isoforms of secreted WNT1 Inducible Signaling Pathway Protein 1, containing 4 conserved Cys-rich domains: a IGFBP domain, a VWFC domain, a TSP type-1 domain, and a CTCK domain. WISP1 up-regulates anti-apoptotic BCL-X(L) protein and attenuates p53-mediated apoptosis induced by DNA damage through activation of AKT kinase. WISP1 binds to, and may prevent the anti-proliferation activity of, decorin and biglycan, small leucine-rich connective tissue extracellular matrix proteoglycans. WISP1 may act as a downstream regulator in the WNT/Frizzled signaling pathway. (NCI)"                                                                                                                                                       
[20265] "Cytokine Receptor Genes encode cell surface Cytokine Receptors that bind paracrine or autocrine cytokine growth factors that stimulate humoral and cellular immune responses, as well as activation of phagocytic cells. Cytokines are secreted by inflammatory leukocytes (lymphokines), by monocytes or macrophages (monokines), and by various other cells. Interleukin lymphokines, targeted to cells of hematopoietic origin, are not secreted by leukocytes but affect the cellular responses of leukocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20266] "The TGFB3 gene at 14q24 encodes Transforming Growth Factor Beta 3, a member of the TGF-beta cytokine family. This secreted protein is expressed as a disulfide-linked homodimer in a wide variety of mesenchymal tissues during human embryogenesis. Transforming Growth Factor Beta 3 is involved in cell differentiation. (from OMIM, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20267] "With a high concentration of estrogen receptors, the uterus is one of the most sensitive tissues to the hormone and demonstrates two basic responses to estrogen: it swells by influx of water into the lumen of the uterus, and it increases in weight by the growth of the endometrial layer. (http://www.fda.gov/cdrh/ost/rpt97/OST1997AR13.HTM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20268] "Inactivation of Breast Cancer Suppressor-2, encoded by the BRCD2 gene, may represent a fundamental step in the pathogenesis of ductal carcinoma of the breast. (OMIM, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20269] "Human DSS1 Gene (DSS1/SEM1 Family) at 7q21.3-q22.1 encodes DSS1 Protein, a highly conserved acidic protein expressed predominantly in limb bud, craniofacial primordia, and skin. DSS1 may be involved in completion of the cell cycle or in differentiation. DSS1 is a homolog of SEM1 (S. cerevisiae), a highly conserved likely regulator of the exocyst complex function and pseudohyphal differentiation. SEM1 protein is mainly cytosolic. DSS1 Protein interacts with a 90 kD C-terminal domain of BRCA2 that binds single-stranded DNA and contains three oligonucleotide-binding folds and a helix-turn-helix motif. DSS1 may be involved in Split Hand/Split Foot Malformation, a limb developmental disorder. (from Swiss-Prot Q13437, OMIM 601285, and NCI)"                                                                                                                                                                                                                            
[20270] "Cell Cycle Genes encode Cell Cycle Proteins, which control the cell division cycle. This family of proteins, classified on the basis of related function, includes a wide variety of classes, including cyclin-dependent kinases, mitogen-activated kinases, cyclins, and phosphoprotein phosphatases, as well as their putative substrates, such as chromatin-associated proteins, cytoskeletal proteins, and transcription factors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20271] "Processes that mark, promote, or produce the conclusion of cell division and promote cell entry into interphase (G0/G1). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20272] "The most frequently occurring constitutional reciprocal translocation in man is t(11;22)(q23;q11). The number of breast cancer cases is significantly higher than expected among the translocation carriers. The information should be useful in connection with counseling and screening. The BRCATA gene may be involved in the pathogenesis of breast cancer and is located at chromosome 11q23. (from OMIM 600048)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20273] "The glutathione (GSH) antioxidant system is foremost among the cellular protective mechanisms. Depletion of this small tripeptide molecule is a common consequence of increased formation of reactive oxygen species during increased cellular activities and oxygen radical generation is frequently a critical step in carcinogenesis. Cysteine is the crucial limiting amino acid for intracellular GSH synthesis. Whey protein concentrate represents an effective and safe cysteine donor for GSH replenishment during GSH depletion in immune deficiency states. Animal experiments have shown that the concentrates of whey proteins increase GSH concentration in relevant tissues and may have anti-tumor effect on low volume of tumor via stimulation of immunity through the GSH pathway. (from PMID 11205219)"                                                                                                                                                                         
[20274] "Signaling Pathway Genes encode proteins or peptides that participate in intracellular signal transduction processes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20276] "These genes encodes G protein-coupled receptors (GPRs or GPCRs). GPRs contain 7 hydrophobic transmembrane domains embedded in hydrophilic intra- and extracellular loops and transduce a variety of hormone, endogenous peptide, and neurotransmitter signals into intracellular effects via G proteins. (from OMIM 604161)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20277] "The GPR54 gene encodes G Protein-Coupled Receptor 54, which is a G protein-coupled receptor. The endogenous ligand of this protein is the KISS1 protein. The truncated form of KISS1, metastin, inhibits chemotaxis and invasion of GPR54-transfected CHO cells in vitro and attenuates pulmonary metastasis of GPR54-transfected B16-BL6 melanomas in vivo. (from OMIM 604161)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20278] "Expressed in brain, human NOVA2 Gene encodes RNA-binding NOVA2 protein, recognized by the paraneoplastic syndrome antibody anti-Ri. NOVA1 and NOVA2 bind to similar RNA ligands with high affinity and may regulate RNA splicing. The NOVA2 KH3 domain interacts with single-stranded RNA; KH3 bound to stem loop RNA resembles a vise, with UCAC held between an invariant Gly-X-X-Gly motif and a variable loop. Tetranucleotide recognition is supported by an aliphatic alpha-helix/beta-sheet RNA-binding platform that mimics UG by making Watson-Crick-like hydrogen bonds with CA. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                   
[20279] "The FABP2 gene encodes Fatty Acid-Binding Protein 2, which belongs to the fatty-acid binding protein (FABP) family thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. The FABP2 gene has a polymorphism in position 54, which changes Ala-54 (71% of the population) to Thr-54 (29%). The Thr-54 allele has a 2-fold greater affinity for long-chain fatty acids than the Ala-54 allele. Thr-54 is associated with increased fat oxidation and insulin resistance. (from LocusLink and Swiss-Prot)"                                                                                                                                                                                                                                                                                              
[20280] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20281] "Baculoviral IAP Repeat-Containing Protein 1, encoded by the BIRC1 gene, contains regions of homology to two baculovirus inhibitor of apoptosis proteins, It is able to suppress apoptosis induced by various signals and inhibits apoptosis in neuronal cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20282] "Widely expressed (highest in heart, ovary; lowest in brain, testis) by human XAF1 Gene (IAP Family), 317-aa 37-kDa XIAP-Associated Factor 1 contains 3 Cys-rich BIR domains (bind to and inhibit caspases), 7 zinc fingers, and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase activity. Associated with nuclear redistribution of XIAP, cytoplasmic XAF1 appears to antagonize nuclear XIAP inhibition of CASP3 activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20283] "The APF1 protein functions to activate caspase 9 in the cytochrome c/dATP-dependent apoptotic pathway. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20284] "Encoded by BIRC2 Gene (IAP Family), Baculoviral IAP Repeat-Containing Protein 2 inhibits apoptosis by binding to TNF Receptor-associated factors TRAF1 and TRAF2 preventing activation of ICE-like proteases. BIRC2 inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20285] "Expressed by Alpha Adrenergic Receptor Genes in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Alpha Adrenergic Receptors are one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Alpha-adrenergic receptors respond to blocking agents such as phenoxybenzamine and phentolamine. When coupled to adenylate cyclase through Gi protein, Alpha Adrenergic Receptor stimulation results in decreased intracellular cyclic AMP. (NCI)"                                                                                                                                                                                                                                                                                                                      
[20286] "Expressed in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Alpha Adrenergic Receptor Genes encode Alpha Adrenergic Receptors, one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Alpha-adrenergic receptors respond to blocking agents such as phenoxybenzamine and phentolamine. When coupled to adenylate cyclase through Gi protein, Alpha Adrenergic Receptor stimulation results in decreased intracellular cyclic AMP. (NCI)"                                                                                                                                                                                                                                                                                                                     
[20287] "Encoded by Mammalian IAP Family Genes, conserved (Inhibitors of Apoptosis) IAP Family Proteins exhibit an N-terminal domain containing 1-3 repeats of a 65-70-aa Cys- and His-rich BIR motif and often a zinc-binding RING finger. Some IAPs inhibit apoptosis by regulating ICE-like protease activation signals and/or inhibit serum deprivation-induced apoptosis. Some IAP proteins may bind to TRAF1 and TRAF2. IAP proteins are frequently over expressed in cancers and associated with resistance to therapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20288] "Encoded by human protooncogene ADRA1B Gene (GPCR1 Family), 519-aa 56.8-kD Alpha-1B Adrenergic Receptor is a Gq/11-associated integral membrane protein that activates mitogenic PI-calcium second messenger responses and controls vascular tone and systolic blood pressure. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20289] "Near ADRB2, ADRA1B, and DRD1A genes and, comprised of 2 exons and a 20-kb intron, 55.8-kb human protooncogene ADRA1B Gene (GPCR1 Family) at 5q23-q32 encodes 519-aa 56.8-kD Alpha-1B Adrenergic Receptor, a Gq/11-associated integral membrane protein that activates mitogenic PI-calcium second messenger responses and controls vascular tone and systolic blood pressure. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20290] "Highly expressed in brain, lung, kidney and fetal heart, liver, brain, 35.5-kb human AKT3 Gene (AKT/RAC Family) at 1q43-q44 encodes alternative isoforms 1 (479-aa, 55.8-kD) and 2 (465-aa; shorter C-terminus) of cytoplasmic Protein Kinase B Gamma, containing a PH domain that binds PI(3)K alpha and promotes plasma membrane translocation after cell stimulation. Fully active when phosphorylated on threonine and serine residues, AKT3 phosphorylates several proteins to regulate cell signaling responses to insulin, PDGF, and IGF1 involved in cell proliferation, differentiation, apoptosis, glycogen synthesis, and glucose uptake. (NCI)"                                                                                                                                                                                                                                                                                                                                         
[20291] "Mammalian IAP Family Genes encode conserved Inhibitors of Apoptosis Proteins with an N-terminal domain containing 1-3 repeats of a 65-70-aa Cys- and His-rich BIR motif and often a zinc-binding RING finger. Some IAPs inhibit apoptosis by regulating ICE-like protease activation signals and/or inhibit serum deprivation-induced apoptosis. Some IAP proteins may bind to TRAF1 and TRAF2. IAP proteins are frequently over expressed in cancers and associated with resistance to therapy. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20292] "Highly expressed in brain, lung, kidney and fetal heart, liver, brain by human AKT3 Gene (AKT/RAC Family) as alternative isoforms 1 (479-aa, 55.8-kD) and 2 (465-aa; shorter C-terminus), cytoplasmic Protein Kinase B Gamma contains a PH domain that binds PI(3)K alpha and promotes plasma membrane translocation after cell stimulation. Fully active when phosphorylated on threonine and serine residues, AKT3 phosphorylates several proteins to regulate cell signaling responses to insulin, PDGF, and IGF1 involved in cell proliferation, differentiation, apoptosis, glycogen synthesis, and glucose uptake. (NCI)"                                                                                                                                                                                                                                                                                                                                                                     
[20293] "The 24-kb human ANXA8 Gene (Annexin Family) at 10q11.2 encodes 327-aa 37-kD Annexin A8 protein, containing 4 annexin repeats (possible Ca (2+) and phospholipid binding sites) and a putative indirect inhibitor of the blood coagulation thromboplastin-specific complex. Annexins are Ca (2+)dependent phospholipid binding proteins. ANXA8 exhibits 56% identity to annexin V (vascular anticoagulant-alpha). Annexin VIII is neither an extracellular protein nor associated with the cell surface suggesting that it may not play a role in blood coagulation. It is expressed at low levels in human placenta and shows restricted expression in lung endothelia, skin, liver, and kidney. The gene is selectively overexpressed in acute myelocytic leukemia. (NCI)"                                                                                                                                                                                                                         
[20294] "Annexin VIII belongs to the family of Ca (2+) dependent phospholipid binding proteins (annexins), and has a high 56% identity to annexin V (vascular anticoagulant-alpha). It was initially isolated as 2.2 kb vascular anticoagulant-beta transcript from human placenta, a Ca (2+) dependent phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. However, the fact that annexin VIII is neither an extracellular protein nor associated with the cell surface suggests that it may not play a role in blood coagulation in vivo and its physiological role remains unknown. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                        
[20295] "Ubiquitously expressed by human ARHGEF1 Gene as alternative isoforms 1 (912-aa, 102-kD) and 2 (879-aa), cytoplasmic Rho Guanine Nucleotide Exchange Factor 1 contains a (homooligomerizing) coiled coil region, a DH domain, a PH domain, and an RGSL domain (necessary for GAP activity). Responsive to extracellular stimuli acting through GPCRs, ARHGEF1 may complex with G proteins and regulates cell cycle and cell proliferation activity. Phosphorylated by PKCA and translocated to the plasma membrane by stimulation, ARHGEF1 seems to regulate RHOA GTPase signal transduction as a GEF and GNA12 and GNA13 (RGS domain interaction) as a GAP. ARHGEF1 GEF activity is inhibited by binding to activated GNA12. (NCI)"                                                                                                                                                                                                                                                                 
[20296] "Ubiquitously expressed 47-kb human ARHGEF1 Gene at 19q13.13 encodes alternative isoforms 1 (912-aa, 102-kD) and 2 (879-aa) of cytoplasmic Rho Guanine Nucleotide Exchange Factor 1, containing a (homooligomerizing) coiled coil region, a DH domain, a PH domain, and an RGSL domain (necessary for GAP activity). Responsive to extracellular stimuli acting through GPCRs, ARHGEF1 may complex with G proteins and regulates cell cycle and cell proliferation activity. Phosphorylated by PKCA and translocated to the plasma membrane by stimulation, ARHGEF1 seems to regulate RHOA GTPase signal transduction as a GEF and GNA12 and GNA13 (RGS domain interaction) as a GAP. ARHGEF1 GEF activity is inhibited by binding to activated GNA12. (NCI)"                                                                                                                                                                                                                                        
[20297] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20298] "Human ACSL1 Gene (bHLH/ASC Family) at 12q22-q23 encodes Achaete-Scute Complex-Like 1 Protein, a bHLH transcription activation factor.  Efficient binding to the E box (5 prime-CANNTG-3 prime) requires dimerization with other bHLH proteins.  HASH1 forms a heterodimer with E12/E47 and plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20299] "Encoded by BIRC3 Gene (IAP Family) Baculoviral IAP Repeat-Containing Protein 3 inhibits apoptosis by binding to TNF Receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. BIRC3 inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring-type zinc finger domain while the Zn binding domain is involved in protein-protein interactions in caspase inhibition and spindle assembly. BIRC3 is present in many fetal and adult tissues and mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes. (NCI)"                                                                                                                                                                       
[20300] "Encoded BIRC4 Gene (IAP Family), Baculoviral IAP Repeat-Containing Protein 4 inhibits apoptosis through binding to TNF Receptor-associated factors TRAF1 and TRAF2. Similar to BIRC2, BIRC4 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. BIRC4 also specifically inhibits cell-death proteases, caspase-3 and caspase-7. A novel transcript homologous to BIRC4 is expressed solely in the testis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20301] "AUH encodes AU-specific RNA-binding enoyl-CoA hydratase that binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20302] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20303] "AU-specific RNA-binding enoyl-CoA hydratase (AUH) protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. (LocusLink)"                                                                                                                              
[20304] "Encoded by BIRC7 Gene, Livin is a potent anti-apoptotic protein and caspase inhibitor with pleiotropic effects on apoptosis induced by various stimuli. BIRC7 anti-apoptotic activity is achieved by two mechanisms: TAK1-dependent JNK1 activation and caspase inhibition. Induced by a death stimulus, processed and activated SMAC interacts with the BIRC7 BIR (baculovirus IAP repeat) domain to abrogate BIRC7 inhibition of apoptosis. Alpha and beta BIRC7 splice variants have different biological properties and tissue distribution, though both have a significant anti-apoptotic activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                     
[20305] "By splicing and translation initiation, p53-regulated 10.6-kb human BAG1 Gene at 9p12 encodes isoforms 1 (274-aa, 31-kD) and 2 (240-aa) of acidic (pI 5.3) glutamate-rich BAG1 Protein, with a Ubiquitin-like domain and BAG domain. BAG1 may link growth factor receptor and anti-apoptotic signal transduction mechanisms. The C-terminal region interacts with HGFR and PDGFR, but the entire protein is required for anti-apoptotic activity. BAG1 stimulates anti-apoptotic membrane protein BCL2. It also binds to NR3C1 and appears to interact with RAF1 Ser/Thr protein kinase, which promotes BCL2 activity. Bound to the HSP70/HSC70 ATPase domain, BAG1 inhibits chaperone activity by promoting substrate release. BAG1 may suppress GADD34-mediated stress responses, have a role in cell survival, and be involved in developmental processes that require cell death. (NCI)"                                                                                                        
[20306] "Encoded by human BAG1 Gene as isoforms 1 (274-aa, 31-kD) and 2 (240-aa), acidic (pI 5.3) glutamate-rich BAG1 Protein contains a Ubiquitin-like domain and BAG domain. BAG1 may link growth factor receptor and anti-apoptotic signal transduction mechanisms. The C-terminal region interacts with HGFR and PDGFR, but the entire protein is required for anti-apoptotic activity. BAG1 stimulates anti-apoptotic membrane protein BCL2. It also binds to NR3C1 and appears to interact with RAF1 Ser/Thr protein kinase, which promotes BCL2 activity. Bound to the HSP70/HSC70 ATPase domain, BAG1 inhibits chaperone activity by promoting substrate release. BAG1 may suppress GADD34-mediated stress responses, have a role in cell survival, and be involved in developmental processes that require cell death. (NCI)"                                                                                                                                                                       
[20307] "Expressed in germ cells in the testis, 4-kb 3-exon human BRS3 Gene (GPCR1 Family) encodes 399-aa 44-kDa integral membrane protein Bombesin-like Receptor 3, specifically activated by bombesin-like peptides and associatied with G proteins that activate a phosphatidylinositol-calcium second messenger system. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin receptor subtype-3 (BRS3). BRS3 may be required for sperm cell division, maturation, or function, or for regulation of endocrine processes and metabolism responsible for energy balance and adiposity. (NCI)"                                                                                                                                                                                                                                                                                                                                                   
[20308] "Expressed in germ cells in the testis by human BRS3 Gene (GPCR1 Family), 399-aa 44-kDa integral membrane protein Bombesin-like Receptor 3 is specifically activated by bombesin-like peptides and associatied with G proteins that activate a phosphatidylinositol-calcium second messenger system. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin receptor subtype-3 (BRS3). BRS3 may be required for sperm cell division, maturation, or function, or for regulation of endocrine processes and metabolism responsible for energy balance and adiposity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                  
[20309] "Expressed at S-phase by human CCNA2 Gene (Cyclin A Subfamily) in all tissues tested (highest in testis), nuclear 432-amino acid 48.5-kD Cyclin A2 accumulates during G2, is abruptly destroyed at mitosis, controls the cell cycle, and promotes both G1/S and G2/M transitions. Inhibition of cyclin A synthesis or activity inhibits DNA synthesis. Highly conserved cyclins (proliferating cell nuclear antigens) regulate CDK kinases. Cyclin A interacts with CDK2 protein kinase and Ser/Thr kinase p34CDC2 (during G2/M) to form a holoenzyme complex; cyclin imparts substrate specificity to the complex. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                     
[20310] "Repressed during G1 and activated at S-phase, the 7.5-kb human CCNA2 Gene (Cyclin A Family) at 4q25-q31 is transcribed into 1.8- and 2.7-kb mRNAs in all tissues tested (highest in testis). Cell cycle gene regulation is mediated by sequences surrounding the transcription start site; Rb protein is not required. HBV integration occurs within an intron. Accumulating during G2 and abruptly destroyed at mitosis, nuclear (at S phase) 432-amino acid 48.5-kD Cyclin A2 controls the cell cycle and promotes both G1/S and G2/M transitions. Inhibition of cyclin A synthesis or activity inhibits DNA synthesis. Highly conserved cyclins (proliferating cell nuclear antigens) regulate CDK kinases. Cyclin A interacts with CDK2 protein kinase and Ser/Thr kinase p34CDC2 (during G2/M) to form a holoenzyme complex; cyclin imparts substrate specificity to the complex. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                 
[20311] "Upregulated by E6 and E7, the tissue expression pattern (G1/S peak) of conserved 15-kb human CCNE2 Gene (Cyclin E Family) at 8q22.1 is distinct from CCNE1 (Cyclin E1) and consistently elevated in tumor cell lines. Splice variants encode distinct nuclear Cyclin E2 isoforms: 1 (full-length 404-aa, 46.8-kD and 47% identical to E1), 2 (359-aa), and 3. Lacking 45 internal residues in the cyclin box, variant 2 does not bind CDK2. Frameshifted truncated variant 3 lacks 112 N-terminal residues. Imparting substrate specificity, short-lived regulatory E2 interacts with CDKs2/3, forms a holoenzyme, controls DNA synthesis, and regulates G1/S. CDK2 phosphorylation of E2 triggers release and likely ubiquitinated degradation. E2 interacts with CDK inhibitors CIP/KIP, which bind and inhibit E2/CDK2. Cyclins E1, E2 may be rate-limiting for G1 progression. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                     
[20312] "Conserved human CCNE2 Gene (Cyclin E Subfamily) encodes distinct nuclear isoforms of Cyclin E2: 1 (full-length 404-aa, 46.8-kD and 47% identical to E1), 2 (359-aa), and 3. Lacking 45 internal residues in the cyclin box, variant 2 does not bind CDK2. Frameshifted truncated variant 3 lacks 112 N-terminal residues. Imparting substrate specificity, short-lived regulatory E2 interacts with CDKs2/3, forms a holoenzyme, controls DNA synthesis, and regulates G1/S. CDK2 phosphorylation of E2 triggers release and likely ubiquitinated degradation. E2 interacts with CDK inhibitors CIP/KIP, which bind and inhibit E2/CDK2. Cyclins E1, E2 may be rate-limiting for G1 progression. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                       
[20313] "The CDC25A gene encodes Cell Division Cycle 25A Protein (CDC25A), a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. This gene is an oncogene, although its exact role in oncogenesis has not been demonstrated. (RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20314] "Cell Division Cycle 25A Protein (CDC25A), encodes by the CDC25A gene, is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. The CDC25A gene is an oncogene, although its exact role in oncogenesis has not been demonstrated. (RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20315] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20316] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20317] "This gene encodes muscarinic acetylcholine receptor M1.  The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13, with MDU1 proximally and COX8 distally located. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20318] "The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13, with MDU1 proximally and COX8 distally located. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20319] "The gene encodes a muscarinic cholinergic receptor that belongs to a larger family of G protein-coupled receptors. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20320] "The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20321] "This gene encodes muscarinic m5 acetylcholine receptor; which affects multiple pathways including phosphatidylinositol metabolism; member of the G protein-coupled receptor family. (Proteome Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20322] "Muscarinic m5 acetylcholine receptor; affects multiple pathways including phosphatidylinositol metabolism; member of the G protein-coupled receptor family. (Proteome Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20323] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20324] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20325] "A key phenomenon in autoimmune diseases (affect about 10% of all populations) is the occurrence of circulating antibodies against the host. The targets of these autoantibodies, the autoantigens, are proteins, nucleic acids, or complexes of both. Some of them are assigned a marker function and are recognized by serum antibodies of patients suffering from a specific disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20326] "Encoded by human AMPH Gene (Amphiphysin Family), 695-amino acid Amphiphysin isoforms of 128- and 108 kD are expressed in neurons, certain endocrine cells, and spermatocytes. The protein may regulate synaptic and endocrine exocytosis. Heterodimeric with AMPHL, AMPH is a non-intrinsic acidic membrane protein concentrated in nerve terminals and associated with the cytoplasmic face of synaptic vesicles. The N- and C-termini are highly conserved between chicken and human; the C-terminal region contains an SH3 domain. AMPH may control membrane associated cytoskeleton properties and protein dysfunction is associated with Stiff-Man Syndrome. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                 
[20327] "Encoded by human FABP3 Gene (FABP/P2/CRBP/CRABP Transporter Family), Fatty Acid-Binding Protein 3 is a 132-amino acid 14.7 kD protein. Demonstrated in liver, heart, intestine, skeletal muscle, and brain, cytoplasmic FABPs are involved in uptake, intracellular metabolism, and/or transport of long-chain fatty acids and their acyl-CoA esters. Fatty Acid-Binding Protein 3 is likely involved in intracellular fatty acid transport, arrests the growth of mammary epithelial cells, and is involved in mammary gland differentiation. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                    
[20328] "The FABP1 gene encodes Fatty Acid-Binding Protein 1, the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein binds free fatty acids and their coenzyme a derivatives, bilirubin, and some other small molecules in the cytoplasm. It may be involved in intracellular lipid transport. (from LocusLink and Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20329] "The FABP4 gene, encodes Fatty Acid-Binding Protein 4, which is a fatty acid binding protein found in adipocytes. This protein binds both long chain fatty acid and retinoic acid and is involved in lipid transport protein in adipocytes. (from LocusLink and Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20330] "Expressed in keratinocytes, human FABP5 Gene (FABP Family) encodes highly conserved 135-aa 15-kDa cytoplasmic Fatty Acid Binding Protein 5, which binds long-chain fatty acids with high specificity and other hydrophobic ligands. Likely involved in fatty acid uptake, transport, or metabolism and in keratinocyte differentiation, FABP5 has highest affinity for C18 chain lengths and decreasing affinity for decreasing chain lengths or chains with double bonds. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20331] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20332] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20333] "Encoded by human BARD1 Gene, nuclear BARD-1 Protein contains a RING zinc finger, three tandem ANK repeats, and two BRCT domains. BARD-1 heterodimerizes with BRCA1 via its N-terminal region and interacts with CSTF-50. BARD1/CSTF1 interacts with RNA Polymerase-2, which may inhibit pre-mRNA cleavage or polyadenylation. BARD-1/RNA Polymerase-2 holoenzyme may sense DNA damage; inhibition by CSTF1 may prevent erroneous polyadenylation of such RNAs. Processed during apoptosis, BARD-1 may mediate apoptosis; homodimers are more susceptible to proteolytic cleavage than BARD1/BRCA1. BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1; a stable BARD1/BRCA1 complex may be essential to BRCA1 tumor suppression. BARD-1 defects are found in primary breast, ovarian and uterine cancers. (from Swiss-Prot Q99728, OMIM 601593, and NCI)"                                                                                                        
[20334] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20335] "Proteins involved in the regulation of cell growth and prevention of uncontrolled cell growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20336] "The serine hydrolases encoded by the serine hydrolase gene are a functional class of hydrolytic enzymes that contain a serine residue in their active site. The serine hydrolases can be grouped into subfamilies that contain closely related members in terms of substrate specificity or amino acid sequence similarity. (from OMIM 603156 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20337] "Encoded by human BPHL Gene (Serine Hydrolase Family), 274-amino acid 30 kD Biphenyl Hydrolase-Related Protein, with structural similarity to enzymes involved in degradation of aromatic compounds, has a putative role in detoxification processes. Highest expression occurs in liver and kidney. Serine hydrolases contain serine in their active site and are grouped into subfamilies in terms of substrate specificity or amino acid sequence. (from Swiss-Prot Q00306, OMIM 603156, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20338] "Removal of a part, pathway, or function by surgery, chemical destruction, electrocautery, or radiofrequency. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20339] "Encoded by human TFF1 Gene (Trefoil Family), 84-amino acid 9 kD (precursor) Trefoil Protein 1 (one trefoil domain) is expressed in stomach and duodenum. Trefoil proteins are stable secretory polypeptides expressed in gastrointestinal mucosa that have at least one trefoil motif (P-type domain), a 40-amino acid domain containing three conserved disulfides, and may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. The exact function has not been determined, but TFF1 may participate in gastrointestinal cell differentiation by delaying G1/S transition and reducing apoptosis. Strong expression is also found in the regenerative tissues surrounding ulcerous lesions of the gastrointestinal tract. (from Swiss-Prot P04155, OMIM 113710, and NCI)"                                                                                                                                                                            
[20340] "Encodes Beta-catenin, an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete. (from OMIM)"                                                                                                                   
[20341] "Cell Adhesion Molecule Genes encode diverse extracellular (e.g., laminin) and cell surface (e.g., NCAM) glycoproteins involved in cell-cell and cell-extracellular matrix adhesion, recognition, activation, tissue integration, wound healing, morphogenesis, and cellular migration. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20342] "Examination of the body by auscultation, palpation, percussion, inspection, and olfaction.  (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20343] "Expressed in pro-B cells until they differentiate into plasma cells, human CD22 Gene at 19q13.1 encodes heterodimeric cell surface glycoprotein CD22 antigen consisting of two subunits that arise by differential RNA processing of the same gene. The larger subunit is composed of an extracellular portion of seven Ig domains and a smaller subunit of five Ig domains. Structurally related to MAG, NCAM, and CEA, CD22 participates in B-cell adhesion to monocytes and T cells. Conserved ITIM motifs in inhibitory receptors are sites for phosphorylation by a SRC kinase and dephosphorylation by tyrosine phosphatase SHP1 or inositol phosphatase SHIP, transducing signals to distinct pathways. CD22 ITIMs interact with SHP1 and oppose activation mediated by the B-cell receptor. CD22 is a negative regulator of antigen receptor signaling. (NCI)"                                                                                                                              
[20344] "Group I: Patients with acute cancer-related pain - associated with diagnosis and/or therapy.  Group II: Patients with chronic cancer-related pain - associated with cancer progression and/or therapy.  Group III: Patients with preexisting chronic pain and cancer pain.  Group IV: Patients with a history of drug addiction and cancer-related pain.  This includes those currently using, in treatment, and former users.  Group V: Dying patients with cancer-related pain. (Kanner)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20345] "The evaluation of pain complaints.  Measurements should be objective on the part of the practitioner, based on subjective information from the patient.  Measurements may also be indirect, by such assessments as respiratory rate and effort, withdrawal, guarding, or other appropriate assessment techniques."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20346] "Any one of several evaluation/assessment tools used to ascertain a patient's condition or diagnosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20347] "ALCAM encodes a cell adhesion molecule which was expressed on mitogen-activated leukocytes and monocytes, fibroblasts, neurons, and tumor-derived cell lines but not on unactivated leukocytes.  ALCAM is a ligand for CD6, a receptor expressed on T-cells involved in cell adhesion interactions between thymocytes and thymic epithelial cells.  ALCAM/CD6 interactions may play a role in the binding of T- and B-cells to activated leukocytes.  ALCAM has five Ig domains and its amino acid sequence has significant homology to chicken neural adhesion molecule BEN/SC-1/DM-GRASP.  (from OMIM 601662 and NCI)"                                                                                                                                                                                                                                                                                                                                                                            
[20348] "Any one of several evaluation/assessment tools used to ascertain a patient's level of pain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20349] "A pain rating scale that includes specific pain criteria and self-reported ratings based upon specific diagnoses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20350] "Expressed in endothelia, monocytes, platelets, and granulocytes, human PECAM1 Gene (CAM/Ig Family) encodes integral membrane glycoprotein CD31 Antigen, a cell adhesion molecule containing six extracellular Ig-like domains, a transmembrane domain, a cytoplasmic domain with six ITIMs, and concentrated at junctions between endothelial cells. PECAM1 appears involved in transendothelial migration of leukocytes, angiogenesis, integrin activation, and may inhibit platelet-collagen interactions. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20351] "This gene belongs to the CEA family of genes. It encodes carcinoembryonic antigen-related cell adhesion molecule 5, a complex immunoreactive glycoprotein with a molecular weight of 180,000 comprising 60% carbohydrate. This gene comprises 9 exons encoding amino acids and 1 encoding a 3-prime untranslated fragment. Originally thought to be a specific antigen of the fetal digestive tract and adenocarcinoma of the colon, the gene product is known to occur normally in feces and pancreaticobiliary secretions and to appear in the plasma in a diverse group of neoplastic and non-neoplastic conditions. It is implicated as a facilitator of hepatic metastasis."                                                                                                                                                                                                                                                                                                                   
[20352] "Expressed in diverse cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts, human CD44 Gene at 11p13 encodes several alternative isoforms of CD44 Antigen, an acidic sulfated glycosylated integral membrane hyaluronate receptor that mediates cell-matrix adhesion, lymphocyte binding to endothelia, lymphocyte activation, macrophage activation, motility, lymph node homing, and immune cell cytokine release. CD44 also functions in a growth factor presentation mechanism necessary for limb development. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                    
[20353] "In pediatrics (and some adult care), providing choices of treatment modalities, times of treatment, and other aspects of care within limits to give the patient a feeling of control and decreases feelings of helplessness associated with the treatment or care."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20354] "Spinal cord section of lateral pathways to relieve pain. This procedure may be done open or percutaneous. (from Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20355] "Cutting off the afferent nerve supply.  Often performed to relieve pain. (Taber's)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20356] "Likely involved in early hematopoiesis, human CD34 Gene at 1q32 encodes 385-aa monomeric CD34 Antigen, a glycosylated type I cell surface membrane protein adhesion antigen selectively expressed on hematopoietic progenitor cells. CD34 may mediate attachment to bone marrow extracellular matrix or stroma as a scaffold for attachment of lineage specific stem cell glycans to stromal or marrow lectins. The ratio of alternatively expressed CD34-T/CD34-F gene products increases with cell differentiation. CD34 is serine phosphorylated by PKC. Abnormal CD34 expression is associated with leukemogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                      
[20357] "Widely and transiently expressed in early embryogenesis and then expressed in differentiated neurons, astrocytes, oligodendrocytes, and myotubes, human NCAM1 Gene (Ig Superfamily) encodes membrane-bound cell surface glycoprotein Neural Cell Adhesion Molecule, which may contain a covalent phospholipid moiety and binds to a variety of cell adhesion proteins to mediate cell-cell and cell-matrix adhesion through homophilic and heterophilic interaction. Important in morphogenetic formation of cell collectives, NCAM1 can mediate homophilic cell aggregation and diverse contact-mediated interactions involved in neuronal adhesion, guidance, and differentiation. Four main isoforms exist, but there are many variants derived from alternative splicing and post-translational modifications. (NCI)"                                                                                                                                                                           
[20358] "A visual representation of the bands of skin innervated by the sensory nerves used for assessment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20359] "Induced by gamma-interferon, human ICAM1 Gene at 19p13.3-p13.2 encodes Intercellular Adhesion Molecule 1, a cell-surface ligand for LFA-1, a cell surface receptor constitutively expressed on some tissues and induced on others in inflammation. ICAM-1 is required for neutrophil migration, leukocyte adhesion, and inflammation. ICAM-1/LFA-1 interaction provides accessory adhesion signals in many immune interactions between T- and B-lymphocytes and between cytotoxic T-cells and their targets. ICAM-1 protein is the major human rhinovirus receptor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                          
[20360] "Any physical, mental, or functional impairment that limits a major activity.  It may be partial or complete. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20361] "Human ICAM2 Gene at 17q23-q25 encodes Intercellular Adhesion Molecule 2, a second LFA-1 ligand and integral membrane protein with two Ig-like domains.  It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20362] "Surgical excision of an intervertebral disc.  Often performed for pain relief."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20363] "An indirect pain assessment scale used by nurses and other professionals to evaluate level of pain/discomfort in demented or otherwise uncommunicative patients. (Kanner)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20364] "A method of pain control used primarily in pediatrics that combines distracting the patient's attention away from the painful procedure or circumstance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20365] "Application of electrical stimulation to the spinal cord, deep brain, peripheral nerves, and Chinese acupoints in an effort to relieve pain.  It is often used in place of or to augment the effectiveness of analgesics. There are many different types of electroanalgesia with varying levels of effectiveness and invasiveness. (White, Li, and Chiu)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20366] "Human ICAM3 Gene at 19p13.3-p13.2 encodes Intercellular Adhesion Molecule 3, a ligand for LFA-1, a major receptor of T-cells, B-cells, and granulocytes that mediates the leukocyte adhesion reactions underlying many immune functions.  The interaction of LFA-1 with ICAM provides essential accessory adhesion signals in many immune interactions, including those between T- and B-lymphocytes and cytotoxic T-cells and their targets.  ICAM3 is potentially the most important ligand for LFA-1 in the initiation of the immune response.  ICAM3 is closely related to ICAM1, consists of five Ig domains, and binds LFA-1 through its two N-terminal domains.  (from OMIM 146631 and NCI)"                                                                                                                                                                                                                                                                                                 
[20367] "Encoded by human tumor suppressor DBCCR1 Gene, 761-amino acid 88.9-kD DBCCR1 Protein contains a MAC/Perforin domain, seven potential N-glycosylation sites, four N-myristoylation sites, and thirty phosphorylation sites. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20368] "The CD58 gene encodes Lymphocyte Function-Associated Antigen-3 (LFA-3), which is a member of the Ig gene superfamily and a ligand for CD2 via heterophilic adhesion between the N-terminal domains. LFA-3 glycoproteins have a wide distribution on hematopoietic and non-hematopoietic cells and are strongly expressed on macrophages. Interaction between CD2 and its counter-receptor, LFA-3, on opposing cells optimizes immune recognition, facilitating contacts between helper T-lymphocytes and antigen-presenting cells as well as between cytolytic effectors and target cells. (from OMIM 153420 and NCI)"                                                                                                                                                                                                                                                                                                                                                                              
[20369] "The covalent chemical or post-translational biochemical addition of an acetyl group(s) to a peptide or protein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20370] "The covalent chemical or post-translational biochemical removal of a phosphate group(s) from a peptide or protein, by phosphatases. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20371] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20372] "Encoded by human CDH3 Gene (CDH Family), 829-amino acid 91 kD (precursor) Placental Cadherin is a homophilic Ca(2+)-dependent cell-cell adhesion type I membrane glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Aberrant expression is observed in cervical adenocarcinomas. Hypotrichosis with juvenile macular dystrophy is caused by production of a truncated protein resulting from a homozygous nucleotide deletion. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20373] "Encoded by human CDH5 Gene (CDH Family), 784-amino acid 87.5 kD (precursor) Vascular Endothelial Cadherin is a Ca(2+)-dependent homophilic endothelial cell-cell adhesion type I membrane glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Expressed specifically in endothelial cells and brain, VE-Cadherin is found mainly at cell-cell boundaries, associated with intercellular junctions. CDH5 may play a role in endothelial cell cohesion and organization of intercellular junctions. CDH5/beta-catenin signaling may control endothelial survival. CDH5 associates with alpha-catenin, forming a link to the cytoskeleton. (from LocusLink, SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                     
[20374] "Encoded by human CDH13 Gene (CDH Family), 713-amino acid 78 kD (precursor) putative tumor suppressor Cadherin 13 is a Ca(2+)-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats. H-Cadherin lacks the conserved cytoplasmic region and is attached to the membrane by a GPI-anchor, unlike typical cadherins. Highest expression is observed in the heart. CNS expression is higher in adult than in fetus.  A putative mediator of cell interactions, this cadherin may inhibit neural cell growth. (from SWISS-PROT, OMIM, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                            
[20375] "A highly invasive form of electroanalgesia used to treat various chronic pain syndromes, which resist treatment by more common means.  It is also used to treat peripheral ischemia, peripheral vascular disease, complex regional pain syndrome, intractable angina, chronic mesenteric ischemia, and diabetic peripheral arterial occlusive disease. (from White, Li, and Chiu)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20376] "A highly invasive form of electroanalgesia mainly used in the management of debilitating chronic pain syndromes after all other less invasive therapeutic modalities (including SCS) have failed. (White, Li, and Chiu)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20377] "A minimally invasive form of electroanalgesia often used in neuropathic pain.  For best effect, the stimulation is applied proximally to the site of the nerve lesion. (from White, Li, and Chiu)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20378] "A minimally invasive form of electroanalgesia involving stimulation of the dermatomal bands proximal to the affected area.  It is often used in the treatment of intractable chronic lower back pain, cancer pain, and other painful disorders. (from White, Li, and Chiu)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20379] "A minimally invasive form of electroanalgesia, similar to PENS but using deeper needles depths, that is used to treat intractable chronic lower back pain, cancer pain, and other painful disorders. (from White, Li, and Chiu)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20380] "A non-invasive form of TENS where the gel pads are placed on acupoints and stimulation is alternated between low-intensity/high frequency and high-intensity/low frequency (dense disperse). (from White, Li, and Chiu)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20381] "A non-invasive form of electroanalgesia produces a direct, localized effect on the conduction of underlying peripheral nerves.  It is often used for dental analgesia, treatment of acute musculoskeletal injuries, postoperative pain, local analgesia, and in treatment of diabetic patients with peripheral neuropathic pain. (from White, Li, and Chiu)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20382] "A non-invasive form of electroanalgesia, based on TENS, that uses the principle of amplitude modulation to decrease the discomfort of stimulating deeper tissues when using transcutaneoulsy applied electrical current.  It is often used in physiotherapy and rehabilitation settings. (White, Li, and Chiu)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20383] "A minimally invasive, experimental form of electroanalgesia based upon the theory that rapid electrical stimulation of A-delta and C pain fibers can lead to nociceptive afferent input depression.  This may be due to exogenous endorphin production release after stimulation. (White, Li, and Chiu)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20384] "A non-invasive form of electroanalgesia that uses conductive gel pads to transmit electrical energy from an external stimulator to peripheral nerves.  There are two forms: low-intensity/high frequency and high-intensity/low frequency (dense disperse).  The method of action is suspected to involve release of endogenous opioids.  It is often used for peripheral neuropathic pain. (from White, Li, and Chiu)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20385] "Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAL encodes the integrin alpha L chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                               
[20386] "The covalent chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, by glycosyl transferases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20387] "Post-translational enzymatic covalent addition of a methyl group(s) to a peptide or protein."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20388] "A pain measurement tool that uses drawn representations of cartoon faces (of the \"smiley face\" variety) that rage from frowning and grimacing to smiling heartily.  These scales can be used objectively by the practitioner or a family member to evaluate the pain expression on the patient's face, or subjectively by having the patient point to the representation that most closely resembles his or her current level of pain.  This scale is often used in pediatrics and geriatrics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20389] "A relaxation technique used in management of stress, pain, and blood pressure.  Its focus is on spontaneous movement, concentration, visual and auditory objectivity, controlled self-consciousness, and responsiveness to interpersonal relationships. (from Fleming)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20390] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20391] "Process by which a nucleic acid macromolecule assumes an energetically favorable three-dimensional conformation as a result of intrinsic and extrinsic atomic physical forces. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20392] "Any subcellular or molecular event, process, or condition involved in receptor-ligand interaction, transduction, processing, integration, discrimination, transmission, or response to a cell communication event, process, or condition. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20393] "P-Selectin is a cell surface adhesion molecule that mediates the interaction of activated endothelial cells or platelets with neutrophils and monocytes.  The protein is detected in megakaryocytes and platelets, as well as in vascular endothelial cells, but not in other cell types.  In endothelia, the protein is localized to the membranes of Weibel-Palade bodies, intracellular storage granules for von Willebrand factor.  CD24 is a ligand for P-selectin.  Sorting nexin-17 interacts with the cytosolic domain of P-selectin and may function in the intracellular trafficking of P-selectin.  (from OMIM 173610 and NCI)"                                                                                                                                                                                                                                                                                                                                                          
[20394] "A form of psychiatric treatment in which six to eight patients meet a specific number of times with a therapist.  The value of this type of therapy is the opportunity for gaining insight from others into one's life experience. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20395] "Expressed by cytokine-induced endothelia, single copy 13-kb human SELE Gene (Selectin Family) at 1q22-q25 contains 14 exons encoding 610-aa 66.5-kD E-Selectin precursor, a type I membrane protein with features homologous to LYAM1: a C-type lectin domain, an EGF-like domain, six cysteine-containing SCR (sushi) domains. Likely having an evolutionary history with complement binding protein genes and neighboring LYAM1 and GRMP, ELAM1 exon-intron boundaries correlate with putative functional regions of the protein. Mediating cell adhesion binding of endothelial cells to leukocytes, such as Neutrophils, during inflammatory responses, ELAM1 recognizes glycolipid polylactosamine derivatives and may be involved in the pathogenesis of atherosclerosis. An aa149 polymorphism is associated with higher risk of coronary artery disease and ELAM1 is a diagnostic indicator of glaucoma. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                       
[20396] "Any subcellular or molecular event, process, or condition involved in reception, transduction, processing, integration, discrimination, transmission, dissemination, or response to a cell communication event, process, or condition related to cell death. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20397] "Any process, condition, or event involved in blood coagulation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20398] "L-Selectin is a cell surface glycoprotein adhesion molecule that serves as a homing receptor for lymphocytes to lymph node high endothelial venules.  The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to C3/C4 binding protein consensus repeat units.  L-Selectin may also play a role in neutrophil adhesion to endothelium at sites of inflammation.  A tissue-specific mucin-like endothelial glycoprotein appears to function as ligand for L-selectin, in the role of scaffold that presents carbohydrates to the L-selectin lectin domain.  PLAUR is directly associated with the carbohydrate-binding domain of L-selectin in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins.  (from OMIM 153240 and NCI)"                                                                                                                                                               
[20399] "The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20400] "This function depends on the presence of the 3'-5' exonuclease activity present on most DNA polymerases and acting in the opposite direction of DNA polymerization. Incorrectly base paired nucleotides are excised at the 3'-end and immediately replaced by the correct one. (From http://www.brunel.ac.uk/depts/bio/project/molgen/bacteria/dnarep/dnar_pr.htm)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20401] "A subcellular or molecular event, function, process, or activity directly involved in the production of a gene product. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20402] "1) Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action at the level of transcription or translation. These processes include gene activation and genetic induction.  2) In relation to the structure and organization of a gene; refers to the regulatory elements that segregate with, and act on, a gene in a cis fashion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20403] "Changes in the regulation of the expression of gene activity without alteration of genetic structure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20404] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20405] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20406] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20407] "Loss or abnormality of psychological, physiological, or anatomic structure or function. (Kanner)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20408] "Psychotherapy of the Freudian school.  In this form of psychotherapy, symbols from the patient's verbalizations, dreams, and interactions are interpreted for meaning in their everyday lives.  Some mental health professionals find this very helpful in defining effective methods for treating chronic pain and pain syndromes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20409] "An exercise that is performed by exerting force against an immovable object or by holding an object in a static position.  This exercise helps to prevent muscle atrophy during the acute pain phase or when other exercises are contradicted. (Kanner)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20410] "An exercise that involves the movement of a constant weight or load through a specified range of motion.  This exercise can build strength and endurance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20411] "An exercise that involves movement at a constant rate with a variable force throughout a specified range of motion.  The advantage of this exercise is that it stresses the muscle being used throughout the entire range. (Kanner)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20412] "A method of intravenous narcotic analgesic delivery that uses a pump or similar delivery system that allows the patient, or in the absence of the patient's ability to do so the patient's nurse or family members, to administer predetermined doses of analgesic as needed to maintain adequate pain control.  This method allows the patient and/or family to have increased autonomy.  Further, research has shown improved pain control and reductions in narcotics necessary to maintain pain control to be associated with this delivery method."                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20413] "The excision of a vertebral posterior arch, usually to remove a lesion or herniated disk. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20414] "The use of light at various frequencies to produce thermal analgesia and prevent damage to nerve and muscle tissue.  It includes ultraviolet, infrared, and low-emission laser frequencies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20415] "Use of low-emission laser therapy has been shown to reduce pain when applied directly to the painful area or to acupuncture points.  The mechanism is unknown.  It has also been shown to postpone post-traumatic neural degeneration. (from Kanner)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20416] "The normal \"downside\" of protein steady state metabolism in cells, involving conjugation, transport, oxidation, and proteolysis; not to be confuse with proteolysis, which applies only to peptide bond hydrolysis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20417] "Cellular or subcellular processes involved in disturbance or restoration of a homeostatic condition. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20418] "Cellular or subcellular processes involved with significant disturbance from a homeostatic condition. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20419] "Cellular or subcellular processes involved with a deliberate effort exerted toward restoration of, a homeostatic condition. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20420] "Any subcellular or molecular event, process, or condition that produces a divergence from the usual wild-type, germline, or pre-existing condition in the primary sequence of a DNA molecule. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20421] "Any subcellular or molecular event, process, or condition that produces a divergence from the usual wild-type, germline, or pre-existing order of nucleotides in the primary sequence of a DNA molecule. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20422] "Any subcellular or molecular event, process, or condition that produces a divergence from the usual wild-type condition in the primary sequence of a peptide or protein molecule. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20423] "Free-standing or institution-based clinics devoted to pain management from a multidisciplinary perspective.  Team members usually include physicians, nurses, social workers, physical therapists, occupational therapists, respiratory therapists, pharmacists, and the patient's family and friends, who approach the patient's needs as a team."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20424] "A procedure in which medicine is injected directly into or around a nerve or into the spine to block pain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20425] "Analgesic delivery into the spinal axis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20426] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20427] "The stimulus-response process involving the stimulation of peripheral pain-carrying nerve fibers (e.g., C-fibers, A-delta fibers) and the transmission of impulses along peripheral nerves of the central nervous system, where the stimulus is perceived as pain. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20428] "Impulse giving rise to sensations of pain. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20429] "A reflex initiated by a painful stimulus. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20430] "A painful and usually injurious stimulus. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20431] "Any subcellular or molecular event, process, or condition involved in translocation of a biological entity, such as a macromolecule, from one site or compartment to another. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20432] "Any subcellular or molecular event, process, or condition immediately and directly involved in the molecular process of DNA replication or preparation for chromosome transfer to daughter cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20433] "Encoded by human GAS8 Gene, 56 kD Growth Arrest-Specific Protein 8 is a ubiquitous 478-amino acid putative tumor suppressor protein. GAS8 amino acid sequence is 96% identical to the mouse homolog, expressed during growth arrest. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20434] "A pain rating scale that attempts objectivity by reliance on a person's ability to rate pain on a scale of 0 to 5, 10, or 100, where the lowest number in the scale represents no pain and the highest number represents the worst imaginable pain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20435] "Shifting from one opiate to another to maintain effectiveness in analgesia while minimizing the side-effect profile."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20436] "Using a drawn representation of the body, patients who are unable to speak mark areas where they feel pain.  Some practitioners use colored pencils or crayons to allow patients to color code areas of more or less severe pain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20437] "The minimum level of stimulation of a body part that a person will perceive as being noxious or unpleasant. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20438] "The degree of pain an individual can withstand. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20439] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20440] "Administration of medications or nutrients directly into the venous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20441] "Subjective reports made by the patient"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20442] "A health/illness/pain management principle specifically directed at the management of pharmacologic agents in maximizing beneficial outcomes and minimizing unfavorable effects."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20443] "Spatially and temporally expressed in many developing organs and induced by serum as well as TGF-beta, human TNC Gene encodes 6 alternative isoforms of secreted multidomain Tenascin C, containing 15 EGF-like repeats, 15 C-terminal fibronectin type III domains, and a fibrinogen C-terminal domain. A ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-v/beta-3 and alpha-v/beta-6, this hexameric extracellular matrix substrate-adhesion glycoprotein appears to inhibit cell migration and promote cell attachment. Homotrimer subunits may be formed in the triple coiled-coil region and stabilized by disulfide-links at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. (NCI)"                                                                                                                                                                                                                                                  
[20444] "The HSPB1 gene at 7q11.23 encodes Heat Shock 27 kD Protein 1, which is involved in stress resistance and actin organization. This protein belongs to the small heat shock protein (HSP20) family. It associates with alpha- and beta-tubulin and microtubules. It is localized in the cytoplasm in interphase cells and colocalizes with mitotic spindles in mitotic cells. It translocates to the nucleus during heat shock. It is expressed in response to environmental stresses such as heat shock, or estrogen stimulation in MCF-7 cells. This protein is phosphorylated in MCF-7 cells on exposure to protein kinase C activators and heat shock. (from Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                 
[20445] "Treatment with analgesics on a schedule or in advance of the return of pain in an attempt to minimize peaks in the pain cycle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20446] "A measure of the health of a population that combines an assessment of both mortality and disability. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20447] "Any of the processes required to bring about cell motility."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20448] "The process of allaying nervous excitement or the state of being calmed. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20449] "This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. (LocusLink)"                                                                                                                                                                            
[20450] "A cellular process that directly affects the ability of a cell to proliferate, grow, divide, or repair damaged cell components. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20451] "A condition in which an individual feels or is made to feel as though he or she has no place within society.  This is often the case with persons who have inadequate support systems or who suffer from stigmatized disease, such as AIDS and mental illness."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20452] "Complex cellular phenomena occurring apart from cell division that support cell viability and differentiated cell function. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20453] "A cellular mechanism directly involved in the process of cell division. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20454] "Encoded by human HMMR Gene and expressed in normal breast tissue, the 724-amino acid 84 kD Hyaluronan-Mediated Motility Receptor is similar to murine Hmmr. A subunit of the HARC complex, the hyaluronan receptor is required for cell motility and may regulate ERK activity. Phosphorylation of several proteins, including pp125-FAK, occurs when Hyaluronan binds HMMR; FAK phosphorylation is necessary for disassembly of focal contacts and motility. HMMR is up regulated in response to wound healing. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20455] "The bodily region or diagnosis from which pain is felt."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20456] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20457] "The occurrence of the pain, whether it is incidental or continuous."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20458] "The extent to which previous pain treatments were successful and the treatment regimens used, including narcotics, alternative/complimentary treatments, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20459] "Any one of the major conceptual subdivisions, based on characteristic cytological and biochemical events, during M Phase of the eukaryotic cell cycle that occur in the order Prophase, Metaphase, Anaphase, and Telophase and lead toward nuclear division. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20460] "Supportive therapy may provide a patient with friendship, encouragement, practical advice such as access to community resources or how to develop a more active social life, vocational counseling, suggestions for minimizing friction with family members, and, above all, hope that the life of the patient may be improved. Depending upon the severity of the symptoms, supportive therapy may begin with a healthcare professional helping the individual to recall the events and emotions that occurred before the acute episode, so that he or she may be able to watch for and recognize approaching signs of trouble. In all situations, supportive therapy involves the teaching of such life skills as managing medication, learning to socialize, handling finances, and getting a job. Ideally, in-patient programs should be linked as much as possible with appropriate community-based programs, to provide a continuing pattern of care. (From Health Canada)"                   
[20461] "Neural blockade of the sympathetic nerve roots."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20462] "Any cell or physiological process concerned with the complex series of local events that involve increased infiltration and activity of leukocytes and an increased blood supply to a site of injury or disease. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20463] "The KITLG Gene encodes Kit Ligand, which is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This gene produces two alternate transcripts: isoform a (lacking exon 6) encodes membrane-bound KITLG; isoform b encodes a protein that includes exon 6, which contains a cleavage site rendering the protein susceptible to post-translational proteolysis yielding soluble KITLG. Soluble KITLG is predominantly found as a non-covalent homodimer. KITLG is a pleiotropic factor that acts in uterus in germ cell and neural cell development, and hematopoiesis, all believed to reflect an KITLG role in cell migration. In adults, KITLG also functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. (from LocusLink)"                                                                                                                                                                                                                
[20464] "Specifically expressed in endothelial cells (induced by TNF and IL-1 alpha), human TNFSF15 Gene (TNF Family) encodes 174-aa 20-kDa homotrimeric type II membrane protein autocrine cytokine Tumor Necrosis Factor Ligand Superfamily Member 15, a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6 with an extracellular C-terminus, a single transmembrane domain, and a short cytoplasmic tail. TNFSF15 inhibits endothelial cell proliferation and angiogenesis, and induces endothelial cell apoptosis by activation of p38 MAPK and caspase-3. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                              
[20465] "Tumor Necrosis Factor Family Genes encode Tumor Necrosis Factor Family Protein, structurally related cell surface proteins involved in lymphocyte homeostasis by induction of apoptosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20466] "The purposeful use of morphine, other opiates, or other pharmaceuticals at doses adequate to end life functions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20467] "An illness that has a prognosis of death."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20468] "The application of heat to appropriate painful areas to improve blood flow and function and to reduce pain.  It can be applied though many methods, using convection, conduction, or radiation.  Conduction uses hydrocollator, paraffin, or other similar methods.  Convection uses immersion hydrotherapy, immersion, forced fluidotherapy, and radiant heat.  Radiation uses laser."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20469] "The application of cold to appropriate painful areas to reduce inflammation immediately after an injury."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20470] "The application of pulling forces to improve functional alignment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20471] "A pain scale marked off like a ruler from 0 to 10 on which the patient marks the current level of pain experienced."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20472] "Expressed in B-cells, human TNFRSF5 Gene (TNFR Family) encodes type I membrane protein isoform I (277-aa) or secreted isoform II (203-aa) of Tumor Necrosis Factor Receptor Superfamily Member 5, containing 4 TNFR-Cys repeats. Adaptor protein TNFR2 interacts with TNFRSF5 and mediates signal transduction. Essential in various immune and inflammatory responses as a receptor for TNFSF5/CD40L, TNFRSF5 interacts with TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6. TNFRSF5 participates in T cell-dependent Ig class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA coordinately regulates expression of TNFSF5 and TNFRSF5. (NCI)"                                                                                                                                                                                                                                                                                                       
[20473] "Developed to promote the sequential use of drugs to achieve effective pain relief.  The first step is a non-opioid medication (such as aspirin, paracetamol, or ibuprofen).  If this does not relieve the pain, an opioid for mild to moderate pain (such as codeine) should be added.  When an opioid for mild to moderate pain in combination with a non-opioid medication does not provide effective analgesia, then an opioid for moderate to severe pain (such as morphine or one in the therapeutic group of morphine) should be substituted.  Adjuvant drugs should be given at any point during drug treatment to relieve adverse effects of analgesics, to enhance pain relief, and to treat concomitant psychological disturbances such as insomnia, anxiety, and depression. (WHO)"                                                                                                                                                                                                      
[20474] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20475] "A biologic function or process involving coordinated groups or populations of single cell types, mixed cell types, or tissues. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20476] "A therapy designed to realign the body with gravity through fascial manipulation. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20477] "The upper limit of efficacy where diminishing returns result from increasing dosages."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20478] "The principal international treaty regulating availability of opioids. It classifies the opioids, and requires the registration of all handlers and the estimation of medical needs for opioids. It establishes rules concerning production, manufacture and distribution, and requires statistical reports. The Single Convention governs how opioids are shipped between countries, using a system of import and export approval. The treaty also defines to some extent the requirements for safe distribution within a country."                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20479] "A multicellular process involved in the formation of new, more mature, or differentiated cells or tissues. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20480] "The neuroadaptation of the body to the presence of an opioid, and is characterized by the onset of acute symptoms and signs of withdrawal if the opioid is stopped or an opioid antagonist is administered."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20481] "Increased resistance to the usual effects of a drug as a result of long-term continual use."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20482] "A behavioral pattern characterized by a craving for the mood-altering effects of a drug and an overwhelming preoccupation with obtaining and using the drug."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20483] "Specifically expressed on CD4+ and CD8+ T-lymphocytes (upregulated by IgE-inducer IL4 and suppressed by IgE-inhibitor gamma-interferon), human TNFSF5 Gene (TNF Family) encodes 261-aa 29-kDa (precursor) homotrimeric type II membrane glycoprotein Tumor Necrosis Factor Ligand Superfamily Member 5. As ligand for CD40 glycoprotein on B cells, TNFSF5 regulates B-cell proliferation, adhesion, Ig class switching, IL4-induced IgE production, and differentiation. A soluble form of TNFSF5 is derived by proteolytic processing of the membrane form. TNFSF5 Defects cause X-linked immunodeficiency. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                
[20484] "A pain rating scale that includes specific pain criteria and self-reported ratings based upon patient verbalizations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20485] "A self-administered questionnaire which measures pain at its worst, its least, average, and right now. Additionally, it uses a check list of adjectives to characterize the pain and information is collected on the impact of treatment and the impact of pain on function. (Dout, 1983)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20486] "A questionnaire incorporating a series of adjectives to describe the characteristics and intensity of pain. The longer version of this instrument was used by Kane and colleagues to evaluate a clinical trial of hospice care. (Wales 1983)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20487] "A questionnaire incorporating a series of adjectives to describe the characteristics and intensity of pain. The longer version of this instrument was used by Kane and colleagues to evaluate a clinical trial of hospice care (Wales 1983)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20488] "A two-sided card that measures pain intensity and the patient's mood on one side, and has a modified version of the Tursky Pain Description Scale on the other. (Fishman 1987)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20489] "Questionnaire designed as part of the APS's guidelines for pain treatment. The instrument measures pain severity, interference, satisfaction with pain control, and various aspects of pain treatment and medication. (APS 1995)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20490] "Measures the sensory and affective components of pain using a magnitude ratio scale. (Gracey 1988)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20491] "Proteins involved in the inhibition of tumor cell metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20492] "Encoded by human KISS1 Gene, the 145-amino acid 15 kD KISS1 Metastasis Suppressor Protein may regulate events downstream of cell-matrix adhesion, perhaps cytoskeletal reorganization. Expressed in placenta, pancreas, and kidney, KISS1 may suppress metastasis without affecting tumorigenicity. Metastin, a placental truncated C-terminally amidated peptide form of KISS1, with 54 amino acid residues, is an endogenous ligand of orphan GPR54 (GPCR) and appears to inhibit chemotaxis and metastasis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20493] "An instrument designed to take into account both pain intensity and duration. (Ventafridda 1983)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20494] "The formation of non-leukoid differentiated blood cells (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20495] "TNFSF10 Gene at 3q26 encodes Tumor Necrosis Factor Ligand Superfamily Member 10, which is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of cells. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. (From LocusLink, OMIM and NCI)"                  
[20496] "The ADAM family consists of transmembrane proteins that contain a disintegrin and metalloprotease domain.  By virtue of these domains they have the potent for both cell adhesion and protease activities. Currently, the ADAM family has 29 membranes, although the function of most ADAM gene products is unknown. The ADAM gene products with known functions act in a highly diverse set of biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-alpha release and the inflammatory response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20497] "A process that promotes the formation of new, more mature, or differentiated tissues, organs, or organ systems. May be, and often is, part of general development, but is not restricted to occur only during general development. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20498] "Expressed in many cell types, human TNFSF6 Gene (TNF Family) encodes 281-aa 31-kDa (precursor) N-glycosylated homotrimeric type II membrane protein cytokine Tumor Necrosis Factor Ligand Superfamily Member 6, FAS ligand. Interaction with cell surface apoptotic receptor TNFRSF6/FAS triggers apoptosis in lymphocytes, while decoy receptor TNFRSF6B/DcR3 binding modulates its effects. Secreted from T-cells upon TCR ligation by MHC/peptide complexes on APCs, the soluble form derives from the membrane form by proteolytic processing. TNFRSF6/FAS-mediated apoptosis may induce peripheral tolerance or antigen-stimulated T-cell suicide. TNFSF6 defects cause ALPS. (NCI)"                                                                                                                                                                                                                                                                                                           
[20499] "Human TNFSF4 Gene (TNF Family) encodes 183-aa 21-kDa homotrimeric type II membrane protein cytokine Tumor Necrosis Factor Ligand Superfamily Member 4, a ligand for receptor TNFRSF4/OX40. In stimulated B cells, along with CD70, this cytokine provides CD28-independent costimulatory signals to T cell proliferation and cytokine production. Involved in T-cell/APC interactions, TNFSF4 also mediates adhesion of activated T cells to vascular endothelia. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20500] "An instrument measuring the affective, sensory and intensity dimensions of pain. (Tursky 1976)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20501] "A 52 item chronic pain inventory. (Kerns 1985)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20502] "A tool designed for cancer patients to measure prevalence and intensity of pain, and identify characteristics associated with unmet analgesic needs and dissatisfaction with pain control. (Zhukovsky 1994)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20503] "A 16 item ordinal scale that measures a patient's knowledge and experience in managing chronic cancer pain. There is also a Family Pain Questionnaire that measures the family caretaker's knowledge and experience."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20504] "Any one of several evaluation/assessment tools used to ascertain a patient's complaints with regard to his or her specific condition or diagnosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20505] "A clinically derived index of the severity of patient dyspnea based on functional impairment, magnitude of tasks that result in dyspnea, and the degree of effort that produces dyspnea. (Mahler 1988)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20506] "A multidimensional index to assess outcomes of clinical trials in patients with COPD. (Guuyatt 1987)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20507] "A scale grading dyspnea from 0 (not troubled with breathlessness except with strenuous exercise) to 4 (too breathless to leave the house or breathless when dressing or undressing). (Brooks 1982)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20508] "A questionnaire designed by the American Thoracic Society that assesses cough, phlegm, wheezing, breathlessness, illness and risk factors. (Brooks 1982)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20509] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20510] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20511] "Encoded by human MSMB Gene (Ig Binding Factor Family, Beta-Microseminoprotein Family), 12.8 kD (precursor) secreted Beta-Microseminoprotein (isoforms PSP94 and PSP57) is expressed in prostate, liver, kidney, breast, penis, pancreas, esophagus, stomach, duodenum, colon, trachea, lung, salivary glands, and fallopian tube. PSP94 is also expressed in lung and breast; PSP57 is found in kidney and bladder. The 94-amino acid seminal protein is derived from a pre-polypeptide of 114 amino acids. Specific receptors are found on spermatozoa and in the prostate. The protein may have inhibin-like activity; it may act as an autocrine paracrine factor in uterine, breast, and other female reproductive tissues and may inhibit pituitary secretion of FSH. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                        
[20512] "Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAM encodes the integrin alpha M chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20513] "Encoded by human TRAF4 Gene, 198-amino acid 22.8 kD TNF Receptor-Associated Factor 4 Protein has an unusual N-terminal RING-type zinc finger motif, a more central cysteine-rich domain containing a CART motif, and a C terminal TRAF domain.  TRAF4 is a member of the TRAF family of proteins that interact with TNF receptors and appears to be involved in TNF-related cytokine signal transduction.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20515] "Human TNF Receptor Family Genes encode transmembrane receptor proteins regulated by TNF Family ligands. TNF receptors typically contain intracelluar death domains involved in the formation of a signal transducing death-inducing complex that includes FADD and caspases that trigger an apoptotic caspase cascade. Some TNF receptors can activate NF-Kappa-B, MAPK3/ERK1, MAPK8/JNK, BIRC1, BIRC2, BAG4/SODD, TRADD, or TRAF2 and transduce inflammation or anti-apoptotic proliferating signals. Some TNF Family Receptors act as competitive decoy receptors in bone resorption or suppress FasL- and LIGHT-mediated cell death. (NCI)"                                                                                                                                                                                                                                                                                                                                                      
[20516] "The CD72 gene encodes CD72 Antigen, whose expression is restricted to B-lineage cells and is turned off in differentiated antibody-secreting plasma cells. CD72 Antigen may participate in signals for B-cell proliferation and differentiation. In the immune system, CD72 appears to be a receptor for leukocyte activation antigen, CD100. CD72 may also be the ligand for CD5, a receptor that regulates T-cell proliferation. (from OMIM 107272, SWISS-PROT P21854, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20517] "The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                           
[20518] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20519] "Expressed in Sertoli cells and liver, 8-exon human SHBG Gene at 19p13.3-13.2 encodes 2 alternative isoforms of 402-aa 44-kDa (precursor) homodimeric secreted glycoprotein Sex Hormone-Binding Globulin, a plasma beta-globulin containing 2 laminin G-like domains that specifically binds one molecule of 5-alpha-dihydrotestosterone, testosterone, or 17-beta-estradiol. An androgen transport protein, SHBG regulates the plasma metabolic clearance rate of steroid hormones by controlling plasma concentration and may be involved in receptor-mediated processes as well. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                           
[20520] "Any of the proteins involved in the enzymatic restoration of DNA structure after chemical, radiation, or spontaneous damage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20521] "Encoded by human NBS1 Gene, ubiquitous expression of 754-amino acid 85 kD Nibrin occurs principally in testis, thymus, and spleen (sites of physiologic DNA double-strand breakage) and liver, lung, striated/smooth muscle, kidney, and gut (high proliferative activity). Nibrin contains a forkhead-associated domain and a C-terminal breast cancer domain. As part of the p95/NBS1/p200/p400/MRE11/RAD50 and the BASC complexes, NBS1 participates in DNA repair and meiotic recombination. Serine phosphorylation by ATM is linked to S-phase checkpoint activation. Nibrin/gamma-H2AX associate with V(D)J recombination sites in response to RAG1-mediated cleavage. Ig Class switch DNA recombination recruits NBS1/gamma-H2AX in G1. NBS1 mutations are associated with Nijmegen breakage syndrome, chromosomal instability, cancer, and cell cycle checkpoint defects. (from Swiss-Prot, OMIM, and NCI)"                                                                                 
[20522] "Any physiological aspect of aging; irreversible changes in an organism that occur over time and lead to a more mature condition. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20523] "Any general physiological process of tissues, organs, or organ systems related to reproduction. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20524] "The CAV1 gene at 7q31.1 encodes Caveolin 1 (CAV1), a scaffolding protein and the main component of the caveolae plasma membranes found in most cell types. CAV1 and CAV2 form Caveolin, a stable hetero-oligomeric complex important in the formation and maintenance of caveolae. In the absence of caveolin no morphologically identifiable caveolae exist, with one exception where in neuronal cells CAV 1 and CAV 2 are expressed but there are no morphologically recognizable caveolae. Caveolin 1 links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. Caveolin expression is correlated both to oncogenic transformation and its reversal. CAV1 is a tumor suppressor candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. Alternative splicing results in 2 isoform proteins (alpha, beta). (NCI)"                                                               
[20525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20526] "Multimeric subcellular structures containing proteins, and possibly, RNA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20527] "The MRE11/RAD50 double-strand break repair complex consists of 5 proteins: Nibrin, p200, p400, MRE11, and RAD50. This complex possesses manganese-dependent single-stranded DNA endonuclease and 3-prime to 5-prime exonuclease activities. In mammalian cells, this complex is important for double-strand break repair, meiotic recombination, and telomere maintenance. It functions in diverse aspects of the cellular response to double strand breaks (DSBs), including the detection of DNA damage, the activation of cell cycle checkpoints, and DSB repair. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                   
[20528] "Human NBS1 Gene at 8q21 contains sixteen exons over 50 kb that encode 754-amino acid Nibrin, likely involved in DNA double-strand break (DSB) repair, checkpoint activation, and apoptosis. C8ORF1 (5-prime), NBS1 (3-prime), DECR1 (5-prime), and CALB1 (3-prime) occur in an 800 kb region. Highly expressed in testis and organs with physiologic DNA DSB or high proliferative activity; 2.4- and 4.4 kb NBS1 transcripts occur widely. Nibrin contains a forkhead-associated domain and a C-terminal breast cancer domain, a Dapin domain, a Nacht domain, and nine Leucine-Rich Repeats. Nibrin is part of the MRE11/RAD50 DSB repair/recombination complex and part of BASC, which may regulate postreplication repair. ATM phosphorylation of Nibrin is linked to S-phase checkpoint activation. NBS1 mutations are associated with Nijmegen breakage syndrome. (from Swiss-Prot Q9NX02, OMIM 602667, and NCI)"                                                                             
[20529] "Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, trans-epithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits an intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20530] "A p53- and tumor necrosis factor alpha-regulated cytoplasmic and mitochondrial protein that belongs to the CLIC family of intracellular chloride channels. mtCLIC associates with the inner mitochondrial membrane. Dual regulation of mtCLIC by two stress response pathways suggested that this chloride channel protein might contribute to the cellular response to cytotoxic stimuli. DNA damage or overexpression of p53 upregulates mtCLIC and induces apoptosis. Overexpression of mtCLIC by transient transfection reduces mitochondrial membrane potential, releases cytochrome c into the cytoplasm, activates caspases, and induces apoptosis. mtCLIC is additive with Bax in inducing apoptosis without a physical association of the two proteins. Antisense mtCLIC prevents the increase in mtCLIC levels and reduces apoptosis induced by p53 but not apoptosis induced by Bax. (From Mol Cell Biol 2002;22:3610-20)"                                                               
[20531] "Expressed in brain (neurons or astrocytes), NOVA Family Genes encode NOVA Family nuclear proteins (NOVA1, NOVA2), autoantigens in POMA recognized by IgG ANNA-2 that contain 3 KH domains and may regulate RNA splicing in neurons and astrocytes. NOVA proteins form structural complexes with other proteins. Found as one or multiple copies of a conserved 70-aa motif in diverse nucleic acid binding, and other, proteins, the KH domain binds RNA; each motif appears necessary for binding. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20532] "Encoded by human NOVA1 Gene (Nova Family), the 510-amino acid 52 kD NOVA-1 Protein is a brain neuron-specific nuclear RNA-binding protein. NOVA-1 contains three KH domains and may regulate RNA splicing or metabolism in specific developing neurons. It binds RNA in a sequence-specific manner to regulate neuron-specific splicing of inhibitory receptor pre-mRNAs in postnatal motor neurons. Murine Nova1 specifically binds to the GLRA2 intronic (UCAUY)3 sequence motif. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20533] "Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The proteins encoded by these genes function in the nuclear transport of protein and RNA. (from LocusLink 4928, OMIM 601021)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20534] "Encoded by human NUP98 Gene (GLFG Nucleoporin Family), 937-amino acid Nucleoporin 98 kD (NUP98) is up regulated by interferon and generated through proteolytic cleavage of a 186 kD precursor yielding NUP98 and NUP96, both associated with the nuclear pore complex (NPC). NPC targeting of NUP96 and NUP98 is cleavage dependent, which may regulate assembly of the NPC, comprised of nearly fifty nucleoporins involved in signal-mediated nuclear import and export of protein and RNA. NUP98 likely functions as an import docking protein. The NUP98 C-terminal RNA-binding domain also contains NPC target sequences, a novel protein fold, and an autocatalytic protease. NUP98 docking/transport function is localized to N-terminal GLFG/FXFG repeats. mRNA nuclear export inhibition by Vesicular Stomatitis Virus M Protein targets NUP98. (from Swiss-Prot, OMIM, and NCI)"                                                                                                         
[20535] "Nucleophosmin is a nucleolar phosphoprotein that is more abundant in tumor cells than in normal resting cells. Stimulation of the growth of normal cells, e.g., mitogen activation of B lymphocytes, is accompanied by an increase in nucleophosmin protein level. Although the function of nucleophosmin has not been defined precisely, ample evidence suggests that it is involved in the assembly of ribosomal proteins into ribosomes. Electron microscopic study indicates that nucleophosmin is concentrated in the granular region of the nucleolus, where ribosome assembly occurs. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                           
[20536] "Growth of a tumor involving either an increase in size of a continuous tumor tissue mass or translocation of tumor cells to secondary sites. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20537] "Expressed predominantly in fetal and adult liver and kidney by human SLC22A1L Gene (Polyspecific Transporter/MDR Family), 424-aa Tumor Suppressing Subtransferable Candidate 5 Protein (Organic Cation Transporter-Like 2 Protein) is a polyspecific organic-cation transporter, containing 10 transmembrane segments, involved in excretion of endogenous and exogenous compounds. SLC22A1L translation may begin at the second methionine, which would result in a 408-amino acid protein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20538] "An event, process, or condition that supports, or results from, tumor development. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20539] "A general physiologic process, usually associated with a specific organ or organ system, typically related to homeostasis and/or energy production. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20540] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20541] "This protein is a member of the BCL-2 family. It positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20542] "A BCL2 related protein that induces apoptosis.  May cause the mitochondrial voltage-dependent anion channel to open and release cytochrome c into the cytoplasm resulting in caspase activation. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20543] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20544] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20545] "This protein belongs to the BCL-2 protein family. It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests the roles of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                    
[20546] "Any subcellular or molecular event, process, or condition involved in supporting or regulating the immune response or immune maintenance. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20547] "This protein is a member of the BCL-2 protein family. Expression of this protein in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20548] "All the reactions in an organism concerned with storing and generating metabolic energy and with the biosynthesis of low-molecular weight compounds and energy-storage compounds. It does not include nucleic acid and protein synthesis.  (Biochemistry, 3rd Ed., Mathews et al., 2000)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20549] "BID (BH3 Interacting domain Death agonist) is a death agonist that heterodimerizes with either agonists (BAX) or antagonists (BCL2). BID is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. (from RefSeq Summary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20550] "Chromogranin Genes encode Chromogranins, widespread heterogenous acidic soluble glycopropolypeptide constituents of neuroendocrine and chromaffin cell secretory granules that elicit an effect themselves or serve as precursors to many biologically active peptides. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20551] "Encodes Chromogranin B, a tyrosine-sulfated secretory protein found in a wide variety of peptidergic endocrine cells.  Chromogranin functions as a neuroendocrine secretory granule protein which may be the precursor for other biologically active peptides. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20552] "The action of synthesizing a DNA product from a viral RNA template by a viral reverse transcriptase. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20553] "This protein is known to interact with cellular and viral survival-promoting proteins, such as BCL2, BCLXL, Epstein-Barr virus BHRF1, and adenovirus E1B 19-kD in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK. (from RefSeq Summary and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20554] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20555] "The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20556] "Hrk is a protein promoting cell death by apoptosis . Hrk physically interacts with the survival-promoting proteins bcl-2 and bcl-xL , which also block cell death induced by expression of Hrk. Hrk does not interact with death-promoting proteins Bax or Bak ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20557] "Encoded by human PHB Gene (Prohibitin Family), evolutionarily conserved ubiquitously expressed Prohibitin is a 272-amino acid 30 kD cytoplasmic antiproliferative protein that inhibits DNA synthesis, regulates proliferation, and may be a tumor suppressor. Prohibitin is expressed in proliferating cells. Mutations in PHB have been linked to sporadic breast cancer. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20558] "Encoded by human BARD1 Gene, nuclear BARD-1 Protein contains a RING zinc finger, three tandem ANK repeats, and two BRCT domains. BARD-1 heterodimerizes with BRCA1 via its N-terminal region and interacts with CSTF-50. BARD1/CSTF1 interacts with RNA Polymerase-2, which may inhibit pre-mRNA cleavage or polyadenylation. BARD-1/RNA Polymerase-2 holoenzyme may sense DNA damage; inhibition by CSTF1 may prevent erroneous polyadenylation of such RNAs. Processed during apoptosis, BARD-1 may mediate apoptosis; homodimers are more susceptible to proteolytic cleavage than BARD1/BRCA1. BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1; a stable BARD1/BRCA1 complex may be essential to BRCA1 tumor suppression. BARD-1 defects are found in primary breast, ovarian and uterine cancers. (from Swiss-Prot Q99728, OMIM 601593, and NCI)"                                                                                                        
[20559] "Encoded by human RAD51C Gene (RECA Family, RAD51 Subfamily), the 376-amino acid 42 kD RAD51 Homolog C is a probable nuclear protein likely involved in meiotic recombination and repair of damaged DNA. Highest expression is observed in testis, heart muscle, spleen, and prostate. RAD51 family members are strand-transfer proteins thought involved in recombinational repair of damaged DNA and in meiotic recombination. RAD51C protein interacts strongly with RAD51B and moderately with XRCC3 DNA repair proteins, but not with itself. The RAD51C/XRCC3 complex binds single-stranded, but not duplex, DNA. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                            
[20560] "Proteins present within the ribosomal subunits. In eukaryotes there are 50 proteins in the large subunit and 33 in the small subunit. (from On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20561] "Encoded by human RPL13 Gene (L13E Ribosomal Protein Family), highly conserved 210-amino acid 24 kD cytoplasmic Ribosomal Protein L13 is a ribosomal 60S subunit protein. The protein is highly basic with no signal or transmembrane sequence, but has two potential nuclear localization signals. Ribosomes consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately eighty structurally distinct proteins. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20562] "Encoded by Ribonucleotide Reductase Subunit Genes (RRM1 and RRM2), the M1 Chain and M2 Chain subunits compose Ribonucleoside-Diphosphate Reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate site and catalytic site regulate enzyme activity. Allosteric control by deoxynucleoside triphosphates and by ATP bound to M1 prevents DNA replication and cell proliferation. An M1 catalytic site only forms in the presence of M2. M2 synthesis is cell-cycle dependent. p53 regulates ribonucleotide reductase by interaction with p53R2 as well as the M2 subunit. (NCI)"                                                                                                                                                                              
[20563] "Encoded by human RRM1 Gene, Ribonucleoside-Diphosphate Reductase M1 Chain is 1 of 2 ribonucleoside-diphosphate reductase subunits, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Complex allosteric control, mediated by deoxynucleoside triphosphates, and by ATP bound to the M1 subunit prevents DNA replication and cell proliferation. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. RRM1 functions as a metastasis suppressor gene through induction of PTEN expression and PTEN-regulated pathways. (from Swiss-Prot, OMIM, LocusLink and NCI)"                                                                                             
[20564] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20565] "Encoded by human S100A2 Gene, 97-amino acid 11 kD S-100L Protein is a member of the S100 Family of cell specific Ca2+-binding proteins containing EF-hand calcium-binding motifs. Induced by growth factors in early G1 and probably by cell-cycle regulation in S phase, S100A2 is preferentially expressed in mammary epithelia and in keratinocytes. S100 proteins are cytoplasmic or nuclear and involved in regulation of cell cycle progression and differentiation. Containing two EF-hand calcium-binding domains, S100 Calcium-Binding Protein A2 interacts with target proteins to link extracellular stimuli to cellular responses and may modulate excess calcium accumulation in mammary epithelial cells. Altered expression of S100A2 has been implicated in breast cancer. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                        
[20566] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20568] "Encoded by human SNCG Gene (Synuclein Family), the highly conserved 127-amino acid 13 kD cytoplasmic Gamma-Synuclein is similar to the amyloid protein nonamyloid beta fragment and to alpha-synuclein and beta-synuclein. SNCG is expressed in brain, heart, skeletal muscle, ovary, testis, colon, spleen, pancreas, kidney and lung. Gamma-Synuclein seems to play a role in neurofilament network integrity and may modulate axonal architecture; it may increase the susceptibility of neurofilament-H to calcium-dependent proteases and may also modulate the keratin network in skin. Phosphorylation by GRK5 appears to occur on residues distinct from other kinase target residues. Gamma-Synuclein is likely involved in the pathogenesis of neurodegenerative diseases and SNCG is expressed at very high level in advanced infiltrating breast cancer. (from Swiss-Prot, OMIM, and NCI)"                                                                                              
[20569] "Encoded by human STIM1 Gene, ubiquitously expressed 685-amino acid 77.5 kD (precursor) Stromal Interaction Molecule 1 Protein is a potential glycosylated cell surface type 1 transmembrane protein that influences the survival or proliferation of B cell precursors and may act as an adhesion molecule in hematopoiesis by mediating attachment to stromal cells. Phosphorylated mainly on serine residues, the protein contains a predicted signal peptide, a transmembrane helix, and one SAM domain. STIM1 oligomerizes with STIM2 and cell binding may require Mn(II). Defects in STIM1 may cause rhabdomyosarcoma and rhabdoid tumors. (NCI)"                                                                                                                                                                                                                                                                                                                                              
[20570] "The PIK3CA gene encodes Phosphoinositide-3-Kinase, Catalytic, Alpha Polypeptide, which belongs to the PI3/PI4-kinase family. Phosphatidylinositol 3 Kinase is a heterodimer of a P110 (catalytic) and a P85 (regulatory) subunit. It phosphorylates PTDINS, PTDINS4P and PTDINS(4,5)P2 with a preference for PTDINS(4,5)P2. (from Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20571] "The DCK gene encodes Deoxycytidine Kinase, which is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20572] "Human MAP2K1 Gene (DSPK/MAP2K Family) encodes 392-aa 43-kDa MAP2K1 Protein, a component/ regulator of the RAS/MAPK intracellular signaling pathway and critical activating protein kinase of MAP kinases such as ERK1 and ERK2 in response to a wide variety of extra- and intracellular signals in processes such as proliferation, differentiation, transcription regulation, and development. MAP kinases act as integration points for multiple biochemical signals. Dependent on Ser/Thr phosphorylation by MAP kinase kinase kinases (RAF/MEKK1), MAP2K1 catalyzes phosphorylation of Thr and Tyr in MAP kinase Thr-Glu-Tyr sequences. p53 activates NFKB through a RAF/MAP2K1/p90(RSK) pathway. (NCI)"                                                                                                                                                                                                                                                                                       
[20573] "Human RIPK1 Gene at 17q23-q24 encodes 74-kDa Receptor-Interacting Serine/Threonine Kinase 1, able to associate with Fas/APO-1 and induce cell death. RIP interacts with the cytoplasmic domain of FAS, and with TNFR1 through the adaptor proteins TRADD and TRAFs 1, 2, and 3. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20574] "Detached cell proliferation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20575] "Encoded by human TACC1 Gene (TACC Family), TACC1 Protein is expressed during early embryogenesis as an 805-amino acid 87.8 kD protein rich in serine, proline, and acidic residues, with a 20-amino acid N-terminus rich in tryptophan, and containing two nuclear localization signals but no DNA- or RNA-binding domains. A 200-residue C-terminus with extensive alpha-helical segments is expected to adopt a coiled-coil structure. Although the nuclear protein is concentrated at centrosomes and interacts with microtubules and tubulin, its function is not yet determined. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                             
[20576] "Human MAPK3 Gene (MAPK Family) encodes MAP Kinase 3 (p44MAPK, ERK1), a Ser/Thr kinase activated in response to extracellular stimuli and widely involved in signal transduction as an integration point for multiple biochemical signals and as part of complex protein kinase cascades involved in a cell proliferation, differentiation, transcription regulation, and development. Phosphorylated/activated by upstream kinases, MAPK3 forms dimers with phosphorylated and unphosphorylated ERK partners, translocates to the nucleus and phosphorylates target transcription factors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                   
[20577] "Human MAPK1 Gene (MAPK Family) encodes alternative p40 and p41 isoforms of Mitogen-Activated Protein Kinase 1, a proline-directed Ser/Thr kinase activated in response to extracellular stimuli and widely involved in signal transduction as an integration point for multiple biochemical signals and as part of complex protein kinase cascades involved in a cell proliferation, differentiation, transcription regulation, and development. Autophosphorylated and phosphorylated/activated by upstream kinases on threonine and tyrosine residues, MAPK1 forms dimers with phosphorylated and unphosphorylated ERK partners, translocates to the nucleus and phosphorylates target transcription factors. MAPK1 phosphorylates MAP2, MBP, and ELK-1. (NCI)"                                                                                                                                                                                                                                   
[20578] "Human MAPK8 Gene (MAPK Family) encodes alternative isoforms (alpha-1, -2, beta-1, -2) of MAP Kinase 8, a stress/cytokine-induced Ser/Thr kinase that acts as an integration point for multiple biochemical signals involved in target transcription factor regulation, such as c-Jun and ATF2. Beta-1 binds c-Jun; alpha-1, -2, and beta-2 bind c-Jun or ATF2. Inhibited by dual specificity phosphatases, and phosphothreonine/tyrosine activated by a Ras-dependent dual specificity MAP2K4/MAP2K7 cascade, MAPK8 mediates immediate-early gene expression. MAPK8 binds scaffolding proteins MAPK8IP1/2/3. MAPK8/UV-induced apoptosis appears related to cytochrome c-mediated cell death. MAPK8 activation by TNF-alpha induces apoptosis. MAPK8 appears to be required for T-helper cell differentiation into Th1 cells. (NCI)"                                                                                                                                                                 
[20579] "The 7-exon 30-kb human TYMS Gene (Thymidylate Synthase Family) encodes 312-aa 36-kDa homodimeric Thymidylate Synthase, a transferase involved in TTP/deoxyribonucleotide biosynthesis that catalyzes MTHF/dUMP conversion to dihydrofolate/dTMP TYMS does not contain a TATA, CAAT, or GC box; intron 1 has 3 CG boxes. Polymorphic 5-prime UTR triple tandem repeated CGCCGCG sequences can form stem-loop secondary structures that affect TYMS activity through translation efficiency. Several tripeptide, tetrapeptide, and octapeptide TYMS sequences are invariant with E. coli, L. casei, and T4 phage; Pro194-Cys195-His196 binds 5-fluoro-2-prime deoxyuridylate. TYMS is considered the primary site of action for 5-fluorouracil and some folate analogs. Competing with MTHFR for MTHF, TYMS maintains the dTMP pool for DNA replication and repair. (NCI)"                                                                                                                            
[20580] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20581] "These proteins are encoded by members of the trefoil family genes. They are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain containing three conserved intrachain disulfide bonds. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20582] "Human MGMT Gene (MGMT Family) encodes 207-aa 22-kDa O-6-Methylguanine-DNA Methyltransferase, a unique and ubiquitous DNA repair enzyme that acts on alkylated guanine and other methylated DNA moities. O(6)-alkylguanine is the major mutagenic and carcinogenic adduct lesion in DNA, induced by simple alkylating mutagens because of its preference for pairing with thymine during DNA replication. Unlike true enzymes, MGMT accepts the O-6 alkyl group from the lesion to a cysteine acceptor residue in the enzyme repairing the alkylated DNA in a stoichiometric second-order suicide reaction; the enzyme is irreversibly inactivated. (NCI)"                                                                                                                                                                                                                                                                                                                                           
[20583] "Important for genomic stability and cell cycle regulation, human TSG101 Gene at 11p15.2-p15.1 encodes a 42.8 kD 381-amino acid Tumor Susceptibility Gene 101 Protein, 94% identical to the mouse protein. Expressed in heart, brain, placenta, lung, liver, kidney, and pancreas, shorter isoforms occur in breast cancers and other tumors. A negative growth and differentiation regulator through association with p21, cytoplasmic TSG101 protein may be a negative ubiquitin regulator; the ubiquitin enzyme-2 variant domain binds to ubiquitin. Nuclear protein, depending on cell cycle stage, interacts with DMAP1. The coiled-coil domain interacts with the cytosolic phosphoprotein Stathmin. TSG101 functions in vacuolar protein sorting and viral budding. Mutations and alternative splicing occur at high frequency in breast cancer during tumorigenesis or progression. (from LocusLink 7251, Swiss-Prot Q99816, OMIM 601387, and NCI)"                                          
[20584] "Human CKB Gene (ATP:Guanido Phosphotransferase Family) encodes 381-aa 43-kDa cytoplasmic homodimer or heterodimer Creatine Kinase, a transferase involved in energy homeostasis that primarily catalyzes reversible formation of ATP and creatine from phosphocreatine. Important in muscle contraction, the reaction stores ATP energy as phosphocreatine. Three cytoplasmic isoenzymes have been identified in human tissues: MM from skeletal muscle, MB from myocardial tissue and BB from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                     
[20585] "Human TNKS Gene (PARP Family) encodes 2 alternative isoforms of ADP-ribosylated 142-kDa ubiquitous Tankyrase; the central domain contains 24 ANK repeats, a motif that mediates protein-protein interactions, and a domain responsible for binding to TRF1; similar to the PARP catalytic domain, the C-terminus has PARP activity. TNKS oligomerizes with TNKS2. TNKS binds via the ANK repeats to the telomeric TRF1 N-terminus and regulates telomere length by inhibiting telomerase; ADP-ribosylation of TRF1 by TNKS may open the telomeric complex, allowing access to telomerase.  Interacting with the cytoplasmic domain of LNPEP/Otase, cytoplasmic TNKS may regulate the subcellular distribution of juxtanuclear SLC2A4/GLUT4-vesicles. Upon insulin-stimulation, TNKS is serine phosphorylated by MAPK kinases. (NCI)"                                                                                                                                                                
[20586] "Expressed in melanocytes, 7-exon 24-kb human TYRP1 Gene (Tyrosinase Family) encodes 537-aa 61-kDa (precursor) type I membrane-spanning glycoprotein Tyrosinase-Related Protein 1, a catalase (no tyrosinase activity) with conserved Cys and His residues involved in oxidation of DHICA to melanochrome in premelanosomes. During melanin synthesis, hydroperoxides are produced during autooxidation of melanin precursor indoles by oxygen; catalase increases the yield of melanin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20587] "Encoded by human TSG101 Gene and expressed in heart, brain, placenta, lung, liver, kidney, and pancreas, 390-amino acid 44 kD cytoplasmic Tumor Susceptibility Gene 101 Protein appears important for genomic stability and cell cycle regulation. A negative growth or differentiation regulator through p21 association and ubiquitin-conjugating enzyme homolog, TSG101 protein may be negative ubiquitin regulator or act in protein-ubiquitin conjugate removal. Nuclear TSG101 protein interacts with DMAP1; the coiled-coil domain interacts with cytosolic phosphoprotein Stathmin. TSG101 functions in vacuolar protein sorting and viral budding. The ubiquitin enzyme-2 variant domain binds to ubiquitin and to the p6 domain PTAP motif of HIV-1 Gag protein. Mutations occur at high frequency in breast cancer during tumorigenesis or progression. (from Swiss-Prot, OMIM, and NCI)"                                                                                                
[20588] "The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. This gene encodes a non-ATPase subunit of the 19S regulator. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (from LocusLink)"                                                                                                                                                                                                                                                                        
[20589] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20590] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20591] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20592] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20593] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20594] "Encoded by human TSSC1 Gene, 387-amino acid 44 kD Tumor Suppressing Subtransferable Candidate 1 Protein is similar to Rb-Associated Protein p48 and chromatin assembly factor CAF1. The gene is located in an imprinted domain associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. (from Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20595] "Encoded by human TSSC3 Gene, 152-amino acid 17 kD TSSC3 Protein is expressed in fetal and adult liver, lung, and kidney, placenta, and adult pancreas. With similarity to TDAG51, essential for FAS expression and susceptibility to apoptosis, TSSC3 may be involved in susceptibility to apoptosis. Mouse Tssc3 encodes a small cytoplasmic protein with a pleckstrin-homology (PH) domain. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20596] "Encoded by human WNT3 Gene (WNT Family), 355-amino acid 39.6 kD (precursor) WNT-3 Protein is a wingless (Drosophila) homolog with 98% amino acid identity to mouse Wnt3 protein and 84% to human WNT3A protein. Highly-conserved structurally related WNT proteins are 350-400 amino acid, cysteine-rich, short-range putative paracrine signaling glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. Wnt3 is required in mouse primary axis formation and anterior-posterior neural patterning in the ectoderm. This protein may play a role in some cancers through activation of the WNT-beta-catenin-TCF signaling pathway. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                      
[20597] "Human HPR Gene (Peptidase S1 Family) at 16q22.1 encodes Haptoglobin-Related Protein (trypanosome lytic factor), with one sushi domain, which confers resistance to Trypanosome brucei.  HPR or HPR-like epitopes are expressed in human breast carcinoma.  Expression of HPR epitopes was associated with earlier recurrence, and multivariate analysis showed that HPR-epitope expression was an independent prognostic factor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20598] "Encoded by human WNT10B Gene (WNT Family), 389-amino acid 43 kD (precursor) WNT-10B Protein is expressed in most adult tissues; heart and skeletal muscle (highest), brain (low; infant brain higher than adult). Highly-conserved structurally related WNT proteins are 350-400 amino acid, cysteine-rich, short-range putative paracrine signaling glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. WNT10B may govern adipogenesis: maintaining undifferentiated preadipocytes through inhibition of adipogenic transcription factors CEBPA and PPAR-gamma. WNT signaling blockage by axin induces these cells to differentiate into adipocytes. This pathway may also affect mesodermal cell fate determination. (from Swiss-Prot, OMIM, and NCI)"                                                                                
[20599] "Expressed in CNS oligodendrocytes by human RTN4 Gene (Reticulon Family), Reticulon 4 A, B, and C (NOGO) is a high molecular weight transmembrane inhibitor of neurite out-growth found in CNS myelin. Reticulon 4 consists of a putative large extracellular domain that inhibits axonal extension with seven predicted N-linked glycosylation sites, two or three transmembrane domains, and a short C-terminal region similar to neuroendocrine-specific proteins and other reticulons. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20600] "Encoded by human ZNF147 Gene (TRIM Family, RING Finger Family), the ubiquitous 630-amino acid 71 kD cytoplasmic estrogen-responsive Zinc Finger Protein 147 has potential DNA-binding and dimerization-transactivation domains, which suggest that ZNF147 may act as a transcription factor similar to other TRIM family members. The TRIM motif includes three zinc-binding domains, a SPRY domain, a RING, a B-Box Type 1 and Type 2, and a coiled-coil region. Zinc Finger Protein 147 is a RING-finger-dependent ubiquitin ligase (E3) that targets proteolysis of 14-3-3-sigma, a negative cell cycle regulator that causes G2 arrest. Lack of EFP function results in 14-3-3-sigma accumulation; 14-3-3-sigma is a target for proteolysis by EFP, leading to cell proliferation. (from Swiss-Prot, LocusLink, OMIM, and NCI)"                                                                                                                                                                 
[20601] "This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. (LocusLink)"                                                                                                                                                                                                                                                       
[20602] "Encoded by human ABCG2 Gene and highly expressed in the placenta, the 655-amino acid 72 kD ATP Binding Cassette Transporter G2 Protein (ABC Family) functions as a membrane-associated homodimeric or homooligomeric xenobiotic transporter likely to be significant in multi-drug resistance.  Involved in trafficking biologic molecules across extra- and intracellular membranes, ATP-binding cassette membrane transporters comprise seven subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White (ABCG).  Related to White (Drosophila) and ADP1 (Yeast), ABCG2 protein confers resistance to mitoxantrone, doxorubicin, and daunorubicin, reduces intracellular anthracycline and daunorubicin accumulation, and causes an ATP-dependent enhancement of rhodamine-123 efflux.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                       
[20603] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20604] "Genes belonging to this family are implicated in several inherited human diseases (Familial Mediterranean Fever, X-linked Opitz/GBBB syndrome, and Mulibrey nanism) and in tumorigenesis. The TRIM proteins have a strong self-association ability that is mediated by their coiled-coil region. This property results in the formation of large protein complexes that identify diverse discrete sub-cellular structures. The formation of these cellular compartments is strictly dependent on the integrity of the Tripartite Motif. The TRIM proteins might play a role in cell sub-compartmentalization. (From http://www.tigem.it/research/Meroni.htm)"                                                                                                                                                                                                                                                                                                                                       
[20605] "The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. Two different binding motifs, RSXpSXP and RXY/FXpSXP, are present in nearly all known 14-3-3 binding proteins. The14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20606] "Inactivation of tumor suppressor BCDS2 Protein, encoded by Breast Cancer, Ductal 2 Gene, may represent a fundamental step in the pathogenesis of ductal carcinoma of the breast.  (OMIM, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20607] "Expressed from multiple promoters in neural and neuroendocrine tissues as 3.4-, 2.3-, and 1.8 kb transcripts, 275-kb human RTN1 Gene at 14q21-q22 encodes 3 isoforms (A, B, C) of Reticulon 1 with unique N termini, localized to ER membranes, and containing a reticulon domain and 2 large C-terminal hydrophobic domains. RTN1 may be involved in neuroendocrine secretion or membrane trafficking. RTN1-A produces a 776-aa 135-kD Ser/Pro-rich protein that contains multiple potential phosphorylation sites; RTN1-B is 356-aa and RTN1-C is 208-aa. RTN1-A and RTN1-B are phosphorylated and expression of RTN1-C is strongly correlated with neuronal differentiation. (NCI)"                                                                                                                                                                                                                                                                                                              
[20608] "Three different proteins encoded by the RTN1 gene. They are identical at their 3-prime ends but have unique amino termini. The common carboxyl-terminal region contains 2 large hydrophobic domains. The proteins are localized to membranes of the endoplasmic reticulum, leading to their proposed designation as 'reticulons.'  Their function is largely unknown. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20609] "Encoded by human DAXX Gene (DAXX Family), ubiquitous nuclear/cytoplasmic Death Domain-Associated Protein 6 is a 740-amino acid 81.4-kD sumoylated putative phosphohomomultimer with NLS, Glu-rich, and JNK activation domains. Bound to TGFBR2 and TNFRSF6 FAS death domain via C-terminus, DAXX bridges apoptotic FAS activation with caspase-independent ASK1 activation of JNK. HSPB1/HSP27-DAXX may block TNFRSF6/ASK1. DAXX co-represses transcription by recruitment to nucleoli or PML/POD/ND10 nuclear bodies through interaction with MCSR1 or PML and directly inhibits PAX3 and ETS1. As part of PAX5/CREBBP complex, DAXX may modulate PAX5 activity. DAXX binds to SLC2A4/GLUT4, CENPC1, UBE2I, PAX7, DEK, HDAC1, HDAC2, HDAC3, and histones H2A, H2B, H3, and H4. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                        
[20610] "Active in neural crest cells during development and expressed primarily in neuroectodermal lineages and vascular smooth muscle in adult tissues, 14-kb 16-exon human MCAM Gene (Ig Superfamily) encodes 646-aa 72-kDa (precursor) Melanoma Adhesion Molecule, a cell surface type I membrane glycoprotein containing 3 Ig-like C2-type domains and 2 Ig-like V-type domains and a possible adhesion molecule homologue of cell adhesion molecule NCAM. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20611] "The most frequently occurring constitutional reciprocal translocation in man is t(11;22)(q23;q11). The number of breast cancer cases is significantly higher than expected among the translocation carriers. The information should be useful in connection with counseling and screening. The BRCATA gene may be involved in the pathogenesis of breast cancer and is located at chromosome 11q23. (from OMIM 600048)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20612] "Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGB2 encodes the integrin beta 2 chain. Mutations in the beta-2 subunit of the leukocyte cell adhesion molecule have been found to cause the autosomal recessive disorder of neutrophil function known as leukocyte adhesion deficiency(from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20613] "The ABCB6 gene at 2q26 encodes a membrane-associated protein that is a member of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies and this protein is a member of the MDR/TAP subfamily. Members of this subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter, containing only 1 transmembrane domain and 1 nucleotide-binding domain, likely plays a role in mitochondrial function. ABCB6 may help maintain respiratory function and may also transport Fe/S clusters from mitochondria to the cytosol, thereby helping to prevent iron accumulation and DNA damage in the organelle. This gene is a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. (NCI)"                                                                                                      
[20614] "The ABL protein is a constitutively active tyrosine kinase that may regulate signal transduction events in the cytoplasm and processes in the nucleus. It is repressed by SH3 domains and possibly by other regions. The ABI-2 gene encodes a protein that is the substrate for ABL. This protein has an SH3 domain and interacts with the ABL. ABI-2 may function to coordinate the cytoplasmic and nuclear functions of the ABL. It modulates ABL transforming activity and functions as a tumor suppressor in mammalian cells. The ABI-2 gene is located at chromosome 2q31-q33. (From LocusLink, OMIM)"                                                                                                                                                                                                                                                                                                                                                                                         
[20615] "The ACK1 gene encodes a non-receptor tyrosine kinase that binds CDC42 in its GTP-bound activated form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of CDC42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The encoded protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of CDC42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. The ACK1 gene is located at chromosome 3q29. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                     
[20616] "Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The ACVR1 gene at 2q23-q24 encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. (LocusLink)"                    
[20617] "Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The ACVR1B gene at 12q13 encodes activin A type IB receptor. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a fourth variant potentially contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. (From LocusLink, OMIM)"                     
[20618] "Activin A receptor, type II-like 1 (also called activin receptor-like kinase 1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The ACVRL1 gene encodes a protein that shares similar domain structures with 3 other closely related ALK proteins (ALK2, ALK3, and ALK4) that together form a subfamily of receptor serine/threonine kinases. ACVRL1 is most highly expressed in human placenta and lung. ACVRL1 deficiency causes hemorrhagic telangiectasia type 2 (HHT2) also known as Rendu-Osler-Weber syndrome 2 (ORW2). The ACVRL1 gene is located at chromosome 12q11-q14. (From LocusLink, OMIM and NCI)"                                                                                                                           
[20619] "The word ontology has a long history in philosophy, in which it refers to the study of being as such. In information science, an ontology is an explicit formal specification of how to represent the objects, concepts and other entities that are assumed to exist in some area of interest and the relationships among them."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20620] "Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The ACVR2 gene at 2q22.2-q23.3 encodes activin A type II receptor, and its sequence is 99% identical to that of the mouse type II receptor gene. (From LocusLink, OMIM)"                                                                                                                                                                                                                                               
[20621] "Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Activin A type II receptor, encoded by the ACVR2 gene, is a receptor for activin A, acivin B, and activin C and constitutively active kinase. Type I receptors are essential for transmembrane signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. (From LocusLink, OMIM and NCI)"                                                                                                                                                                     
[20622] "Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The ACVR2 gene at chromosome 3p22 encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. (From LocusLink)"                                                                                                                                                                                                                                 
[20623] "Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A type IIB receptor, encoded by the ACVR2 gene and a receptor for activin A, activin B, and activin C, displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. (From LocusLink, Swiss_Prot)"                                                                                                                                                                                   
[20624] "Metalloproteinase Genes encode Metalloproteinases (endopeptidases) that use a metal ion, normally zinc, in the catalytic process and preferentially cleave the Gln-Gly peptide bond. Metalloproteinases are inactivated by metal chelators. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20625] "The ADAMTS1 gene encodes a disintegrin and metalloproteinase with thrombospondin motif-1. The encoded protein is a member of the ADAMTS protein family and contains 2 disintegrin loops and 3 C-terminal TS motifs. It cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. It has anti-angiogenic activity and inhibits endothelial cell proliferation. This gene is composed of 9 exons and its expression may be associated with various inflammatory processes as well as development of cancer cachexia. It is likely to be necessary for normal growth, fertility, and organ morphology and function. The ADAMTS1 gene is located at chromosome 21q21.2. (From LocusLink)"                                                                                                                                                                                                                                                                     
[20626] "A disintegrin and metalloproteinase with thrombospondin motifs-1 (ADAMTS-1), encoded by the ADAMTS1 gene is a member of the ADAMTS protein family. It cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. It has anti-angiogenic activity and inhibits endothelial cell proliferation. ADAMTS1 may be associated with various inflammatory processes as well as development of cancer cachexia. It is likely to be necessary for normal growth, fertility, and organ morphology and function. ADAMTS1 is secreted and associated with the extracellular matrix. The Spacer Domain and the TSP Type-1 Domains are important for a tight interaction with the extracellular matrix. ADAMTS1 is expressed as a 110-kD protein, an 85-kD protein after cleavage at the subtilisin site, or as a 67-kD protein, which is most abundant, generated by an additional processing event. (From LocusLink, Swiss_Prot and NCI)"                               
[20627] "This gene encodes a disintegrin and metalloproteinase with thrombospondin motifs-9 (ADAMTS9), which is a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains four C-terminal TS motifs. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. (LocusLink)"                                                                                                                                                                                                                                                                                                                                         
[20628] "A disintegrin and metalloproteinase with thrombospondin motifs-9 (ADAMTS9), encoded by the ADAMTS9 gene, is a member of the ADAMTS protein family. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This enzyme contains four C-terminal TS motifs. The spacer domain and the TSP Type-1 domains are important for a tight interaction with the extracellular matrix. The precursor is cleaved by a furin endopeptidase. Two isoforms, a long form and a short form, may be produced by alternative splicing. ADAMTS9 is secreted and associated with the extracellular matrix. It is highly expressed in all fetal tissues and expressed slightly in adult ovary, pancreas, heart, kidney, lung, placenta, spinal cord and brain. (From LocusLink, Swiss_Prot and NCI)"                                                                                                                                                    
[20629] "The JUP gene encodes Plakoglobin (gamma-Catenin), which is a major soluble and membrane-associated cytoplasmic protein common to desmosomes and intermediate junctions. It associates with the cytoplasmic region of Desmoglein I and mediates the connection of cadherins to actin filaments and to other transmembrane and peripheral cytoplasmic proteins in epithelial adherens junctions. The cadherin-catenin complex interacts with EGFR; beta-Catenin and Plakoglobin are tyrosine phosphorylated by activated EGFR. APC binds to and regulates beta- and gamma-Catenin. Homologues of Drosophila armadillo, beta-Catenin and gamma-Catenin have analogous structures and functions in cell adhesion and the WNT signaling pathway. Several mutations of gamma-Catenin have transforming activity dependent on TCF/LEF and c-MYC function. Beta- and gamma-Catenin may have distinct roles in WNT signaling via differential effects on downstream target genes. (from OMIM 173325 and NCI)"
[20630] "Enzyme Genes encode Enzymes, biological molecules (usually proteins) that possess catalytic activity. Catalytic RNA and catalytic DNA molecules have also been identified. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20631] "Lyase Genes encode Lyases, a class of enzymes that catalyze the hydration-dehydration cleavage of C-C, C-O, C-N, and other bonds by means other than hydrolysis or oxidation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20632] "Adenylyl cyclases are membrane-associated enzymes that are expressed in most human tissues. These enzymes catalyze the formation of cAMP and are regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The ADCY9 gene encodes adenylyl cyclase that is a widely distributed. It is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. The ADCY9 gene is located at chromosome 16p13.3. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20633] "The ADRA1A gene encodes alpha-1A-adrenergic receptor that regulates smooth muscle contraction, cellular growth and apoptosis. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. Alternative splicing of the ADRA1A gene generates 4 transcript variants, which encode 4 different isoforms with distinct C termini but having similar ligand binding properties. The ADRA1A gene is located at chromosome 8p21-p11.2. (From LocusLink)"                                                                                                                                                                                                                                                                                                                        
[20634] "Alpha-1A-adrenergic receptor, encoded by the ADRA1A gene, regulates smooth muscle contraction, cellular growth and apoptosis. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This alpha-adrenergic receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(Q) and G(11) proteins. Alternative splicing of the ADRA1A gene generates 4 transcript variants, which encode 4 different isoforms with distinct C termini but having similar ligand binding properties. Its carboxyl-terminal SER or THR residues may be phosphorylated. (From LocusLink, Swiss_Prot and NCI)"                                                                             
[20635] "The ADRA2A gene encodes alpha-2A-adrenergic receptor and it contains no introns in either its coding or untranslated sequences. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Both the alpha2A and alpha2C subtypes are required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibits transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulates neurotransmission at lower levels of nerve activity. The ADRA2A gene is located at chromosome 10q24-q26. (From LocusLink)"                                                                                           
[20636] "Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. These receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. Alpha-2A-adrenergic receptor is encoded by the ADRA2A gene. Both the alpha2A and alpha2C subtypes are required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibits transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulates neurotransmission at lower levels of nerve activity. (From LocusLink, Swiss_Prot and NCI)"                                                                                                                                                                                                                                          
[20637] "Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The ADRA2B gene 2p13-q13 encodes the alpha2B subtype, which is associated with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. This polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. (From LocusLink)"                      
[20638] "Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The alpha2B subtype, encoded by the ADRA2B gene is associated with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. This polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. (From LocusLink)"                                  
[20639] "The CD14 gene encodes CD14 Antigen, a surface protein preferentially expressed on monocytes/macrophages. This protein binds lipopolysaccharide binding protein and recently has been shown to bind apoptotic cells. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20640] "Expressed by T lymphocytes, human CD28 Gene at 2q33 encodes CD28 Antigen, a glycosylated cell surface membrane protein with Ig homology and significant sequence identity with CTLA-4. Both bind to B7 ligand; CTLA-4 exhibits greater affinity. B7 antigen-presenting cells regulate T-cell activation by delivering antigen-independent stimulatory signals through CD28 and inhibitory signals through CTLA-4. CD28 undergoes tyrosine phosphorylation after interacting with B7.  Phosphorylation in the CD28 cytoplasmic domain allows recruitment of signaling proteins such as PI3K, GRB2, and GADS via their SH2 domains.  (NCI)"                                                                                                                                                                                                                                                                                                                                                           
[20641] "Expressed in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Beta Adrenergic Receptor Genes encode Beta Adrenergic Receptors, one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Beta-adrenergic receptors respond to blocking agents such as propranolol and to activating agents such as isoproterenol. Beta-1 type receptors mediate lipolysis and increase cardiac rate and force of contraction; beta-2 type receptor activation promotes bronchial and vascular smooth muscle relaxation. When coupled to adenylate cyclase through Gs protein, Beta Adrenergic Receptor stimulation results in increased intracellular cyclic AMP. (NCI)"                                                                                                          
[20642] "The ADRB2 gene encodes beta-2-adrenergic receptor that is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. Beta-2 adrenergic receptor stimulates adenylyl cyclase activity. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. The ADRB2 gene is located at chromosome 5q32-q34. (From LocusLink)"                                                                                            
[20643] "Expressed as a 3.7-kb mRNA in hemopoietic cell lineages, 90-kb 16-exon human LCP1 Gene encodes 627-aa 70-kDa monomeric phosphorylated L-Plastin, a conserved cytoplasmic actin-binding protein identical to IL2-stimulated phosphoprotein p65 in T-cells and containing a blocked N-terminus, 2 EF-hand calcium-binding domains, a calmodulin-binding site, 4 calponin-homology (CH) domains, and two tandem actin-binding domains. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20644] "Ligand Binding Protein Genes encode Ligand Binding Proteins, a large class of diverse proteins for which a major function appears to be (typically high affinity) binding of some ligand for soluability, transport, bioactivity regulation, or other nonenzymatic process. Ligand interaction often alters protein molecular conformation and function. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20645] "A single human tumor suppressor VCL Gene at 10q22.1-q23 encodes a 1,066-amino acid Vinculin with strong similarity to other vinculins and to alpha-catenins. Human and chicken sequences exhibit greater than 95% identity. As a result of alternative splicing, metavinculin contains additional 68-79 variable and highly conserved amino acids near the C-terminus. Involved in cell adhesion, vinculin is associated with the cytoplasmic face of adherens-type junctions and involved in anchoring F-actin to the plasma membrane. Vinculin is phosphorylated on serines, threonines, and tyrosines and is acylated by myristic acid and/or palmitic acid. Vinculin exhibits self-association properties and appears to be the major talin-binding protein in platelets; 150 kD metavinculin also interacts strongly with talin.  (Omim, Swiss-Prot, LocusLink, and NCI)"                                                                                                                      
[20646] "Encoded by human ADRB2 Gene (GPCR Family), Beta-2 Adrenergic Receptor directly associates with one of its effectors, class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. This signaling complex assembly ensures specific and rapid signaling by this G protein-coupled receptor that stimulates adenylyl cyclase activity. Polymorphisms, point mutations, and/or downregulation of ADRB2 are associated with nocturnal asthma, obesity, and type 2 diabetes. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                              
[20647] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20648] "ATP-Binding Cassette, Sub-Family B, Member 6, encoded by the ABCB6 gene, is a membrane-associated protein of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. It could be involved in the transport of heme from the mitochondria to the cytosol. This gene is a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. (From LocusLink, Swiss_Prot and NCI)"                                                                                                                                                             
[20649] "The ABL protein is a constitutively active tyrosine kinase that may regulate signal transduction events in the cytoplasm and processes in the nucleus. It is repressed by SH3 domains and possibly by other regions. ABL-Interactor 2, encoded by the ABI-2 gene, is the substrate for ABL. This protein has an SH3 domain and interacts with the ABL. ABI-2 may function to coordinate the cytoplasmic and nuclear functions of the ABL. It modulates ABL transforming activity and functions as a tumor suppressor in mammalian cells. (From LocusLink, OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20650] "ACSL1 is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. ACSL1 plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. The protein is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests it may also play a role in tumor formation. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                 
[20651] "Human oncogene Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family Member B Gene at 9q22.32 encodes PHAPI2, a product with similarity to PHAPI.  (Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20652] "Human APS Gene at 7q22 encodes 85 kD APS Protein in 9 exons spanning at least 36.5 kb.  A 2.3 kb transcript is found in spleen, prostate, testis, uterus, small intestine, and skeletal muscle; a smaller transcript is found in peripheral blood leukocytes.  The 632-amino acid adaptor protein contains a PH domain, a SH2 domain, and a C-terminal tyrosine phosphorylation site.  APS is structurally similar to the T-cell adaptor protein/signal transducer LNK and is tyrosine-phosphorylated after BCR cross-linking.  APS associates with SHC regardless of BCR stimulation and with GRB2 after BCR stimulation.  (OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                         
[20653] "Human Adenomatous Polyposis Coli Like Gene at 19p13.3 encodes tumor suppressor APC2 Protein, similar to APC, which regulates formation of active Beta Catenin/TCF complexes.  (Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20654] "Human A Kinase Anchor Protein 9 Gene at 7q21-q22 is widely expressed as six alternatively spliced transcripts: isoform 1, 2, 3/CG-NAP, 4/Yotiao, 5, and 6/AKAP350.  An 11 kb transcript is expressed in skeletal muscle, pancreas, heart, placenta, and brain.  The full-length protein contains many coiled-coil regions.  Centrosomal, cytoskeletal, cytoplasmic, or associated with postsynaptic densities, AKAP9 appears to be a scaffolding protein for protein kinases and phosphatases.  AKAP9 interacts with the regulatory region of PKN, PP2A, PP1 and PKC Epsilon.  Highly expressed in the pancreas and at synapses, isoform 4/Yotiao interacts with a NMDA receptor NR1 subunit intracellular alternatively spliced C-terminus and may modulate synaptic transmission.  Yotiao binds to PP1and to PKA RII, indicating that it is an AKAP.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                
[20655] "Human AKAP12 Gene at 6q24-q25 encodes A Kinase Anchor Protein 12, expressed in endothelial cells, but not platelets, or peripheral blood cells.  Two isoforms may be produced by alternative splicing.  The 1,780-amino acid cytoplasmic anchoring protein appears to mediate compartmentation of PKA and PKC in the cortical cytoskeleton.  Its amphipathic alpha helix binds to the PKA RII subunit and tethers the enzyme near its substrates.  Activated by lysopc, AKAP12 inhibits PKC.  Polybasic regions are involved in binding PKC.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                          
[20656] "The A-Kinase Anchor Proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. The AKAP13 gene at 15q24-q25 encodes A Kinase Anchor Protein 13. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, and in addition function as protein kinase A-anchoring proteins. (From LocusLink and NCI)"          
[20657] "Human Aldehyde Dehydrogenase 1 Family Member A2 Gene at 15q21.1-q21.2 encodes a 499-amino acid putative cytoplasmic homotetrameric NAD-dependent retinaldehyde dehydrogenase, similar to class 1 aldehyde dehydrogenases that synthesizes retinoic acid from retinaldehyde.  The protein contains conserved aldehyde dehydrogenase motifs: a GXGXXXG motif NAD-binding domain, two peptide motifs, and cys301, critical for aldehyde group interaction.  ALDH1A2 and CYP26A1 regulate local retinoic acid levels that act as a signal in developing and adult tissues; CYP26A1 metabolizes retinoic acid.  In T-ALL, ectopically expressed TAL1 and LMO in T cells form a complex with GATA3 on the RALDH2-T promoter and activate transcription.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                                     
[20658] "Human oncogene Aldo-Keto Reductase Family 7 Member A2 Gene at 1p35.1-p36.23 encodes the widely expressed 330-amino acid AFAR polypeptide similar to rat Afar, to a Shaker-related voltage-gated potassium channel, and to aldose reductase.  Aldoketoreductases (AKRs) detoxify aldehydes and ketones; AFAR is the principal liver reductase for 2-carboxybenzaldehyde and can metabolize Aflatoxin B1 protein-binding dihydrodiol.  AFAR may protect the liver against the toxic and carcinogenic effects of Aflatoxin B1.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20659] "Human AS3 Gene encodes 1391-amino acid 158-kD Androgen-Induced Prostate Proliferative Shutoff Associated Protein, a likely androgen-induced tumor suppressor that mediates G0/G1 cell cycle arrest (androgen-induced proliferative shutoff). AS3 has putative transactivating features, protein-protein interaction motifs (coiled-coil and leucine zipper), and DNA-binding domains, suggesting that AS3 is a transcription factor. AS3 also has a protein-kinase motif, suggesting that it may phosphorylate a target protein.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20660] "Human Angiopoietin 1 Gene at 8q22.3-q23 encodes a 498-amino acid secreted glycoprotein ANGPT1 ligand for TIE2 receptor that contains a predicted coiled-coil domain and a fibrinogen-like C-terminus.  Its expression in developing blood vessels indicates an action in vascular development.  Antagonized by Angiopoietin-2, ANGPT1 activates endothelial TIE2 by inducing its tyrosine phosphorylation.  ANGPT1 structure differs from other angiogenic factors or ligands for receptor tyrosine kinases and its actions are distinct from VEGF, necessary for early stages of vascular development.  ANGPT1 acts in vascular remodeling, maturation, and stability.  ANGPT1 and TIE1 are critical for right side, but not left side, venous system development.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                   
[20661] "Human Angiopoietin 2 Gene at 8p23.1 encodes a 68 kD 496-amino acid secreted homodimeric Angiopoietin 2 that contains a fibrinogen-like C-terminus.  ANG2 is nearly 60% identical to ANG1.  A 61 kD homodimeric alternative ANG2(443) product lacks 53 amino acids found in ANG2 encoded by exon B and part of the N-terminal coiled-coil domain.  Like ANG2 and ANG1, secreted ANG2(443) binds endothelial TIE2 receptor tyrosine kinase, but not TIE1.  ANG2(443) partially inhibits ANG2 and ANG1 binding to TIE2.  As an ANG1 and TIE2 antagonist, ANG2 may counteract blood vessel maturation or stability by loosening cell-matrix contacts and inducing endothelial apoptosis.  With VEGF, ANG2 may facilitate endothelial cell migration and proliferation.  In adults, ANGPT2 is only expressed at the sites of vascular remodeling.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                          
[20662] "Human Anti-Mullerian Hormone Receptor Type II Gene at 12q13 encodes a receptor for Anti-Mullerian Hormone within 11 exons.  Exons 1 to 3 encode the extracellular domain, exon 4 corresponds to the transmembrane domain, and the remaining exons encode the intracellular Ser/Thr kinase.  The 573-amino acid type II receptor does not appear to undergo alternative splicing.  Type II receptors bind ligand but require a type I receptor for signal transduction.  Anti-Mullerian Hormone (AMH/MIS/MIF), produced by Sertoli cells, induces regression of Mullerian ducts, which differentiate into the uterus and fallopian tubes.  Type I persistent Mullerian duct syndrome is caused by AMH gene mutation; type II syndrome is due to AMHR mutation.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                         
[20663] "The 3-prime terminus of human ERCC1, a DNA repair gene, overlaps the 3-prime end of Antisense to ERCC-1 Gene at 19q13.2-q13.3.  This exceptional type of overlap is conserved in mouse and even in yeast RAD10, an ERCC1 homolog, suggesting an important biologic function.  ASE1 appears to encode CD3-Epsilon-Associated Protein.  (OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20664] "Human ALOX15 gene, a putative mutator gene, at 17p13.3 maps close to tumor-suppressor TP53 gene.  TP53 regulates ALOX15 in human and mouse.  Cytoplasmic ALOX15 protein (Lipoxygenase family) acts in leukotriene biosynthesis and is implicated in anti-inflammation, membrane remodeling, and cancer development or metastasis.  It converts arachidonic acid to 15s-hydroperoxyeicosatetraenoic acid.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20665] "The 4.4-kb human ARMET Gene (ARMET/ARP Family) at 3p21.1 encodes a highly conserved potentially secreted 234-aa arginine-rich ARMET Protein with unknown function. The presence of a specific mutation changing codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20666] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20667] "Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20668] "Human oncogene RAS Homolog Gene Family Member H Gene at 4p13 encodes a 191-amino acid hemopoietic cell RHOH/TTF polypeptide on 2 exons spanning 35 kb.  Exon 2 contains the entire coding region, which encodes residues associated with binding and hydrolysis of GTP.  ARHH belongs to the small GTPase superfamily, RHO family; highest identity is found with RHO-like CDC42 protein.  ARHH is involved in a t(3;4)(q27;p11) chromosomal translocation with BCL6.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20669] "ACSL1 is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. ACSL1 plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. The protein is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests it may also play a role in tumor formation. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                 
[20670] "Encoded by Genes with Unknown or Unclassified Function, Proteins (or RNAs) with Unknown or Unclassified Function have currently unidentified or unspecified cellular functions. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20671] "Encoded by human APS Gene, 85 kD APS Protein appears to be found in spleen, prostate, testis, uterus, small intestine, skeletal muscle, and peripheral blood leukocytes.  The 632-amino acid adaptor protein contains a PH domain, a SH2 domain, and a C-terminal tyrosine phosphorylation site.  APS is structurally similar to the T-cell adaptor protein/signal transducer LNK and is tyrosine-phosphorylated after BCR cross-linking.  APS associates with SHC regardless of BCR stimulation and with GRB2 after BCR stimulation.  (OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20672] "Encoded by human APCL Gene, 2303-amino acid 244 kD tumor suppressor APCL Protein is similar to APC and regulates formation of active Beta-Catenin/TCF complexes.  (Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20673] "Encoded by human AKAP9 Gene, 3911-amino acid 454 kD A Kinase Anchor Protein 9 is widely expressed as alternative isoforms: 1, 2, 3/CG-NAP, 4/Yotiao, 5, and 6/AKAP350.  Full-length protein contains many coiled-coil regions.  Centrosomal, cytoskeletal, cytoplasmic, or associated with postsynaptic densities, AKAP9 appears to be a scaffolding protein for protein kinases and phosphatases.  AKAP9 interacts with the regulatory region of PKN, PP2A, PP1 and PKC Epsilon.  Highly expressed in the pancreas and at synapses, isoform 4/Yotiao interacts with a NMDA receptor NR1 subunit alternatively spliced intracellular C-terminus and may modulate synaptic transmission.  Yotiao binds to PP1 and PKA RII, indicating that it is an AKAP.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                              
[20674] "Encoded by human AKAP12 Gene, A Kinase Anchor Protein 12 is expressed in endothelial cells, but not in platelets or peripheral blood cells.  The 1,781-amino acid 191 kD cytoplasmic anchoring protein appears to mediate compartmentation of PKA and PKC in the cortical cytoskeleton.  Its amphipathic alpha helix binds to the PKA RII subunit and tethers the enzyme near its substrates.  Activated by lysopc, AKAP12 inhibits PKC. Polybasic regions are involved in binding PKC.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20675] "Expressed in many tissues, human EZH2 Gene (EZ Family/PcG Family) encodes 746-aa 85-kDa nuclear Enhancer of Zeste Homolog 2 protein, containing a SET domain, that may be involved in regulation of gene transcription and chromatin structure in the hematopoietic and central nervous systems. PcG proteins form multimeric protein complexes involved in transcriptional repression over successive cell generations. EZH2 appears to associate with embryonic ectoderm development protein VAV1 and with ATRX via the SET domain. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20676] "A non-invasive imaging method that uses a thermal sensitive camera to capture a digital image based on heat radiating from the body. In trials for detection of breast cancer, computer-assisted interpretation of the digital image helps to determine whether a local abnormality in breast tissue temperature is present, which may indicate the presence of disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20677] "Encoded by human oncogene AKAP13 Gene, 424-amino acid 49 kD A Kinase Anchor Protein 13 is a signal transduction RHO/RAC GEF involved in cytoskeletal organization and cell cycle progression.  Alpha helical hydrophilic LBC is conserved among vertebrates and expressed in skeletal muscle, heart, lung, and hematopoietic cells.  It contains phosphorylation sites, N-terminal DH and PH domains, and an N-terminal EF-hand motif.  LBC binds to PKA RII tethering it near substrates.  AKAP13 stimulates RHO/RAC, but not CDC42 or RAS.  In ovary, placenta, breast, and testis, 170 kD BRX contains a LBC region preceded by 3 novel regions; C-terminal regions 4 and 5 bind to the ESR1 ligand-binding domain.  BRX also binds RXR, PPAR, and THR.  Chimeric onco-LBC lacks the C-terminus, which promotes transforming activity.  Proto-LBC is membrane bound; onco-LBC is cytosolic.  (OMIM, Swiss-Prot, and NCI)"                                                                        
[20678] "Encoded by human ALDH1A2 Gene, Aldehyde Dehydrogenase 1A2 (ADH Family) is a 499-amino acid 54.8 kD putative cytoplasmic homotetrameric NAD-dependent retinaldehyde dehydrogenase, similar to class 1 aldehyde dehydrogenases that synthesizes retinoic acid from retinaldehyde.  The protein contains conserved aldehyde dehydrogenase motifs: GXGXXXG motif NAD-binding domain, two peptide motifs, and cys301, critical for aldehyde group interaction.  ALDH1A2 and CYP26A1 regulate local retinoic acid levels that act as a signal in developing and adult tissues; CYP26A1 metabolizes retinoic acid.  In T-ALL, ectopically expressed TAL1 and LMO in T cells form a complex with GATA3 on the RALDH2-T promoter and activate transcription.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                                   
[20679] "Encoded by human oncogene AKR7A2 Gene, widely expressed 330-amino acid 36.6 kD AFAR polypeptide (Aldo/Keto Reductase 2 Family) is similar to rat Afar, to a Shaker-related voltage-gated potassium channel, and to aldose reductase. Aldoketoreductases (AKRs) detoxify aldehydes and ketones; AFAR is the principal liver reductase for 2-carboxybenzaldehyde and can metabolize Aflatoxin B1 protein-binding dihydrodiol.  AFAR may protect the liver against the toxic and carcinogenic effects of Aflatoxin B1.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20680] "Encoded by human AS3 Gene, 1391-amino acid 158 kD AS3 Protein appears to be an androgen-induced tumor suppressor that mediates G0/G1 cell cycle arrest (androgen-induced proliferative shutoff). AS3 protein has putative transactivating features, protein-protein interaction motifs (coiled-coil and leucine zipper), and DNA-binding domains, suggesting that AS3 is a transcription factor. AS3 also has a protein-kinase motif, suggesting that it may phosphorylate a target protein.  (Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20681] "Encoded by human Annexin A5 Gene, Annexin A5 is a 35 kD 320-amino acid monomeric placental protein similar to PP4-X that contains 4 annexin repeats; some may bind calcium and phospholipid.  PP4 and PP4-X (Lipocortin family) are similar to lipocortin I and calpactin I.  PP4 is also an Annexin family member, Ca(2+)-dependent phospholipid binding proteins located on the plasma membrane cytosolic face.  PP4 forms a voltage-dependent membrane Ca(2+) channel; key amino acids act as selectivity filters and voltage sensors, regulating pore permeability to ions.  As an anticoagulant protein, PP4 acts as an indirect inhibitor of the blood coagulation cascade thromboplastin-specific complex.  PP4 may bind ATRX.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                                                 
[20682] "Encoded by human AMHR2 Gene, the 573-amino acid 62.7 kD Anti-Mullerian Hormone Receptor Type II Ser/Thr protein kinase (TGFB Receptor Family) is a type I membrane protein.  Type II receptors bind ligand but require a type I receptor for signal transduction.  Anti-Mullerian Hormone (AMH/MIS/MIF), produced by Sertoli cells, induces regression of Mullerian ducts, which differentiate into the uterus and fallopian tubes.  Type I persistent Mullerian duct syndrome is caused by AMH gene mutation; type II syndrome is due to AMHR mutation.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                              
[20683] "The 3-prime terminus of human ERCC1, a DNA repair gene, overlaps the 3-prime end of Antisense to ERCC-1 Gene.  This exceptional type of overlap is conserved in mouse and even in yeast RAD10, an ERCC1 homolog, suggesting an important biologic function.  ASE1 appears to encode a 399-amino acid 43 kD ASE1 Protein.  (Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20684] "Encoded by human ALOX15 Gene, a putative mutator gene regulated by tumor-suppressor TP53, 661-amino acid 74.7 kD cytoplasmic Arachidonate 15-Lipoxygenase (Lipoxygenase Family) acts in leukotriene biosynthesis and is implicated in anti-inflammation, membrane remodeling, and cancer development or metastasis.  It converts arachidonic acid to 15s-hydroperoxyeicosatetraenoic acid.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20685] "Encoded by human oncogene ARMET Gene, ARMET Protein is a highly conserved arginine-rich putative secreted product that belongs to the ARMET family.  (Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20686] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20687] "Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. This protein binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20688] "Encoded by human oncogene ARHH Gene, the 191-amino acid 21 kD hemopoietic cell RHOH/TTF Protein contains residues associated with binding and hydrolysis of GTP.  ARHH belongs to the small GTPase superfamily, RHO family; highest identity is found with RHO-like CDC42 protein.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20689] "Activated p21cdc42Hs Kinase, encoded by the ACK1 gene, is a non-receptor tyrosine kinase. It binds CDC42 in its GTP-bound activated form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of CDC42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The encoded protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of CDC42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                               
[20690] "form of electron microscopy based on scanning with an extremely narrow beam that is transmitted through the sample; the detection apparatus produces an image whose brightness depends on the atomic number of the sample, and therefore reveals chemical composition as well as gross molecular shape."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20691] "Human BMP10 Gene (TGF-beta Family) encodes 424-aa 48-kD homodimeric secreted Bone Morphogenetic Protein 10, a putative growth factor that may signal through receptor serine/threonine kinases involved in trabeculation of the embryonic heart. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20692] "Genes that code for growth factors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20693] "Expressed in a variety of tissues, Transforming Growth Factor-Beta Family Genes encode Transforming Growth Factor-Beta, an autocrine growth factor that can act synergistically with TGF-alpha in embryonic development, cellular differentiation, hormone secretion, and immune function. There are at least three forms of TGF-beta: TGF-beta 1, TGF-beta 2, and TGF-beta 1.2. The latter is a heterodimer of TGF-beta 1 and TGF-beta 2. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20694] "Encoded by human BMP10 Gene (TGF-beta Family), 424-aa 48-kD homodimeric secreted Bone Morphogenetic Protein 10 is a putative growth factor that may signal through receptor serine/threonine kinases involved in trabeculation of the embryonic heart. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20695] "The BMP15 gene encodes a protein that is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9. Bone morphogenetic protein 15 signals through receptor serine/threonine kinases. The BMP15 gene is located at chromosome Xp11.2. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                              
[20696] "Bone Morphogenetic Protein 15 encoded by the BMP15 gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9. Bone morphogenetic protein 15 signals through receptor serine/threonine kinases. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                            
[20697] "The BMP2 gene encodes a protein that belongs to the transforming growth factor-beta (TGFB) superfamily. By signaling through receptor serine/threonine kinases, Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. The BMP2 gene is located at chromsome 20p12. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20698] "Bone Morphogenetic Protein 2, encoded by the BMP2 gene, is a protein that belongs to the transforming growth factor-beta (TGFB) superfamily. By signaling through receptor serine/threonine kinases, Bone morphogenic protein 2 induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20699] "The BMP3 gene encodes a protein that belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein 3 induces bone formation by signaling through receptor serine/threonine kinases. It is expressed in lung, ovary and small intestine. The expression signals of BMP3 mRNA in malignant schwannoma are relatively lower than in benign lesions. The BMP3 gene is located at chromosome 4p14-q21. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20700] "Bone Morphogenetic Protein 3 (Osteogenic), encoded by the BMP3 gene that belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein 3 induces bone formation by signaling through receptor serine/threonine kinases. It is expressed in lung, ovary and small intestine. The expression signals of BMP3 mRNA in malignant schwannoma are relatively lower than in benign lesions. (From LocusLink, Swiss_Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20701] "The BMP5 gene at chromosome 6p11.1 encodes a protein that is a member of the TGF-beta family of growth factors. Morphogenetic Protein 5 signals through receptor serine/threonine kinases and induces cartilage and bone formation. It is expressed in the lungs and liver. The expression signals of BMP-5 mRNA in malignant schwannoma are relatively lower than in benign lesions. (From LocusLink, Swiss_Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20702] "Bone Morphogenetic Protein 5, encoded by the BMP5 gene, is a member of the TGF-beta family of growth factors. Morphogenetic Protein 5 signals through receptor serine/threonine kinases and induces cartilage and bone formation. It is expressed in the lungs and liver. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20703] "The BMP6 gene at chromosome 6p24-p23 encodes a protein that is a member of the TGF-beta family. Bone morphogenetic protein 6 has strong similarity to murine Bmp6, signals through receptor serine/threonine kinases, and is involved in endochondral bone formation. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20704] "Bone morphogenetic protein 6, encoded by the BMP6 gene, is a member of the TGF-beta family. It has strong similarity to murine Bmp6, signals through receptor serine/threonine kinases, and is involved in endochondral bone formation. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20705] "The BMP7 gene at chromosome 20q13 encodes a protein that is a member of the TGF-beta family. Bone morphogenetic protein 7 signals through receptor serine/threonine kinases and has very strong similarity to murine Bmp7. At all anatomical sites disrupted by Holt-Oram syndrome mutations, BMP7 is expressed in all structures that are altered in Holt-Oram Syndrome patients, including the heart, proximal and distal forelimb, clavicle, and scapula, as well as other unaffected tissues. BMP7 is also expressed in the neural retina, lens, and developing cornea. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                       
[20706] "Bone Morphogenetic Protein 7 (BMP7), encoded by the BMP7 gene, is a member of the TGF-beta family. BMP7 signals through receptor serine/threonine kinases and has very strong similarity to murine Bmp7. BMP7 plays a role in calcium regulation and bone homeostasis. It induces cartilage and bone formation and may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. BMP7 is expressed in the kidney and bladder and lower levels are seen in the brain. At all anatomical sites disrupted by Holt-Oram syndrome mutations, BMP7 is expressed in all structures that are altered in Holt-Oram Syndrome patients, including the heart, proximal and distal forelimb, clavicle, and scapula, as well as other unaffected tissues. (NCI)"                                                                                                                                                                                                                    
[20707] "The BMP8 gene encodes a protein that is a member of the TGF-beta family of growth factors. Bone morphogenetic protein 8 signals through receptor serine/threonine kinases and plays a role in Bone Development and Maintenance. (From OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20708] "Bone morphogenetic protein 8 (BMP8), encoded by the BMP8 gene, is a member of the TGF-beta family of growth factors and signals through receptor serine/threonine kinases. BMP8 plays a role in calcium regulation and bone homeostasis. It induces cartilage and bone formation and may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20709] "The 12-kb 5-exon human CD2 Gene encodes 351-aa 39.5-kDa (precursor) type I transmembrane glycoprotein T-Cell Surface Antigen CD2, containing an IgV domain, an IgC2 domain, and a proline-rich basic cytoplasmic domain implicated in signaling in T-cell triggering. The domain involved in cell adhesion is encoded by a single exon. LFA3/CD58 and CD48/BCM1 interaction with CD2 mediates adhesion between T cells and other cells. CD2 interaction with LFA3 on opposing cells optimizes immune recognition and facilitates helper T lymphocyte contact with antigen-presenting cells. CD2 may interact with CD2AP. (NCI)"                                                                                                                                                                                                                                                                                                                                                                     
[20710] "The CD4 gene at 12pter-p12 encodes CD4 Antigen (P55), which is a T-cell surface glycoprotein. CD4 has a role in cell-cell interactions and may act in signal transduction. CD4 is a accessory protein for MHC class-II antigen/T-cell receptor interaction and functions to initiate or augment the early phase of T-cell activation. CD4 enhances T-cell sensitivity to antigen and binds to LCK, which phosphorylates CD3-zeta. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20711] "A molecule that helps control immune responses in the body.  B7-1 is involved in stimulating T-cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20712] "Receptor Serine/Threonine Kinase Genes encode receptor proteins that each bind to specific signaling factors causing a conformational and functional change in the ligand-bound receptor, altering its interaction with target molecules, increasing the receptor kinase activity, and leading to changes in cellular physiology through modification of the activity of one or more signal transduction pathways."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20713] "Bone Morphogenetic Protein Receptor Genes encode Bone Morphogenetic Protein Receptors, activated by Bone Morphogenetic Proteins, non-collagenous bone-growth regulatory factors synthesized as large precursor molecules that are cleaved by proteolytic enzymes and form an active homodimer or heterodimer of two related bone morphogenetic proteins that stimulate osteogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20714] "This gene encodes for a type I bone morphogenetic protein (BMP) receptor that is a transmembrane serine/threonine kinase. Germline mutations in BMPR1A cause a subset of juvenile polyposis syndrome and Cowden syndrome. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20715] "The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Germline mutations in BMPR1A cause a subset of juvenile polyposis syndrome and Cowden syndrome. (From LocusLink)"                                                       
[20716] "The BMPR2 gene at chromosome 2q33-q34 encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this type II receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. This gene expresses two transcript variants."                                                                              
[20717] "Encoded by human BMPR2 Gene (BMP Receptor Family), Bone Morphogenetic Protein Receptor Type II is a type II transmembrane serine/threonine kinase receptor for BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. BMP receptors transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling; type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. (NCI)"                                                                                                                                                                  
[20718] "Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC, TXK, ITK, and BTK. All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain. The BMX gene at chromosome Xp22.2 encodes an 80-kD protein that is a nonreceptor tyrosine kinase. BMX may play a role in the growth and differentiation of hematopoietic cells. BMX is transcribed and translated in bone marrow as well as human endothelial cells. There is no obvious phenotype with loss of BMX function, suggesting that this tyrosine kinase has a redundant role in arterial endothelial signal transduction. (From OMIM)"                                                                                                                                                                            
[20719] "The CD8B1 gene encodes CD8 Antigen, Beta Polypeptide 1, which is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. This protein, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. Six alternative transcripts encoding different isoforms, four membrane associated and two secreted, have been identified. A pseudogene, also located on chromosome 2, has been identified. (from LocusLink)"                                                                                                                                         
[20720] "Expressed in bone marrow and endothelia by human BMX Gene, intracellular 80-kD BMX Non-Receptor Tyrosine Kinase is a member of the non-receptor tyrosine kinase family (contain an SH3 and SH2 domain upstream of the TK domain) that includes TEC, TXK, ITK, and BTK; homologs of Src28 TK (Drosophila). BMX may play a role in growth and differentiation of hematopoietic cells. There is no obvious phenotype associated with loss of BMX function, suggesting that this tyrosine kinase has a redundant role in arterial endothelial signal transduction. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                               
[20721] "This gene at chromosome 8p21 encodes a member of the BCL2/adenovirus E1B 19 kD-interacting protein (BNIP) family. It promotes apoptosis by interacting with the antiapoptotic E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as cellular Bcl2 and Bcl2L1, also an apoptotic protector. This protein is a functional homolog of BNIP3, a proapoptotic protein, and may function simultaneously with BNIP3. It may play a role in tumor suppression. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20722] "BCL2/Adenovirus E1B 19kd Interacting Protein 3-Like, encoded by the BNIP3L gene, is a member of the BCL2/adenovirus E1B 19 kD-interacting protein (BNIP) family. It promotes apoptosis by interacting with the antiapoptotic E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as cellular antiapoptotic proteins Bcl2 and Bcl2L1. It can overcome the suppressers bcl-2 and bcl-xl, although high levels of bcl-xl expression will inhibit apoptosis. This protein is a functional homolog of BNIP3, a proapoptotic protein, and may function simultaneously with BNIP3. It may play a role in tumor suppression. (From LocusLink)"                                                                                                                                                                                                                                                                                                                
[20723] "This gene encodes a mitogen-activated kinase which localizes to the nucleus. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human gene may be part of a signal transduction pathway involved in growth control. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20724] "Bromodomain Containing Protein 2, encoded by the BRD2 gene is a mitogen-activated kinase which localizes to the nucleus. Homologous to the Drosophila gene female sterile homeotic, Bromodomain Containing Protein 2 may be part of a signal transduction pathway involved in growth control and may function in spermatogenesis. This protein contains 2 bromodomain and 1 ET domain but is not involved in the immune response. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20725] "The BRDG1 gene at chromosome 4q13.1 encodes BCR Downstream Signaling 1, a docking protein that acts downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The encoded protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart. It has a proline-rich region, a pleckstrin homology domain and SH2 domain. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20726] "BCR Downstream Signaling 1, encoded by BRDG1 gene, functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. This protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart. It has a proline-rich region, a pleckstrin homology domain and SH2 domain. (From LocusLink, Swiss_Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20727] "The BTG1 gene at chromosome 12q22 is a member of a family of antiproliferative genes. It negatively regulates cell proliferation and has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The BTG protein is degraded by the ubiquitin-proteasome system and the C-terminal region is necessary and sufficient to control its stability. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20728] "B-Cell Translocation Protein 1, encoded by the BTG1 gene, is a member of a family of antiproliferative proteins. It negatively regulates cell proliferation. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The BTG protein is degraded by the ubiquitin-proteasome system and the C-terminal region is necessary and sufficient to control its stability. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20729] "The ADRBK1 gene at chromosome 11q13 encodes beta-adrenergic receptor kinase (ADRBK1), which phosphorylates the beta-2-adrenergic receptor and mediates agonist-specific desensitization observed at high agonist concentrations. ADRBK1, an ubiquitous cytosolic enzyme, translocates from the cytosol to the plasma membrane upon agonist stimulation and specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by ADRBK1, an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. Inhibition of ADRBK1 is a novel mode of therapy. (From LocusLink)"                                       
[20730] "Beta-adrenergic receptor kinase 1 (ADRBK1), encoded by the ADRBK1 gene, phosphorylates the beta-2-adrenergic receptor and mediates agonist-specific desensitization observed at high agonist concentrations. ADRBK1, an ubiquitous cytosolic enzyme, translocates from the cytosol to the plasma membrane upon agonist stimulation and specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by ADRBK1, an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. Inhibition of ADRBK1 is a novel mode of therapy. (From LocusLink)"                                                           
[20731] "The ADRBK2 gene at chromosome 22q12.1 encodes Adrenergic, Beta, Receptor Kinase 2 (ADRBK2), which specifically phosphorylates the agonist-occupied and -activated form of the beta-adrenergic and related G protein-coupled receptors. ADRBK2 regulates desensitization of G protein-coupled receptors. Overall, the ADRBK2 enzyme has 85% amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95% similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20732] "Adrenergic, Beta, Receptor Kinase 2 (ADRBK2), encoded by the ADRBK2 gene, specifically phosphorylates the agonist-occupied and -activated form of the beta-adrenergic and related G protein-coupled receptors. ADRBK2 regulates desensitization of G protein-coupled receptors. Overall, the ADRBK2 enzyme has 85% amino acid similarity with ADRBK1, with the protein kinase Catalytic Domain Having 95% Similarity. (From Locuslink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20733] "The AF5q31 gene at chromosome 5q31 encodes a transcription factor. It is expressed in fetal heart, lung, and brain at relatively high levels and in fetal liver at a low level, but the expression in these tissues is decreased in adults. The AF5q31 protein is homologous to AF4-related proteins, including AF4, LAF4, and FMR2. The AF5q31 and AF4 proteins have 3 homologous regions, including the transactivation domain of AF4. Infantile acute lymphoblastic leukemia (ALL) with rearrangements of the MLL gene is characterized by early pre-B phenotype and poor treatment outcome. The AF5Q31 gene is a fusion partner of the MLL gene involved in the pathogenesis of 11q23-associated ALL. (From LocusLink and OMIM)"                                                                                                                                                                                                                                                                
[20734] "ALL1 Fused Gene From 5q31, a protein encoded by the AF5q31 gene, is a transcription factor. It is expressed in fetal heart, lung, and brain at relatively high levels and in fetal liver at a low level, but the expression in these tissues is decreased in adults. The AF5q31 protein is homologous to AF4-related proteins, including AF4, LAF4, and FMR2. The AF5q31 and AF4 proteins have 3 homologous regions, including the transactivation domain of AF4. Infantile acute lymphoblastic leukemia (ALL) with rearrangements of the MLL gene is characterized by early pre-B phenotype and poor treatment outcome. The AF5Q31 gene is a fusion partner of the MLL gene involved in the pathogenesis of 11q23-associated ALL. (From LocusLink and OMIM)"                                                                                                                                                                                                                                       
[20735] "The AGTR2 gene at chromosome Xq22-q23 encodes Angiotensin Receptor 2, which is an intergral membrane protein and a member of G-protein coupled receptor family. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame. (From LocusLink)"                                                                                                                                                                                                                                                              
[20736] "Angiotensin Receptor 2, encoded by the AGTR2 gene, is an intergral membrane protein and a member of G-protein coupled receptor family. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20737] "Based upon sequence analysis the AIM1 protein appears to be a member of the beta-gamma crystallin superfamily.  However, it is the first mammalian member of the family with a primarily non-lens role.  Other parts of the predicted AIM1 protein sequence have weak similarity with filament or actin-binding proteins. The authors suggested that AIM1 is a good candidate for the putative suppressor of malignant melanoma on chromosome 6 (Trent et al., 1990), possibly exerting its effects through interactions with the cytoskeleton. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20738] "Based upon sequence analysis the AIM1 protein appears to be a member of the beta-gamma crystallin superfamily.  However, it is the first mammalian member of the family with a primarily non-lens role.  Other parts of the predicted AIM1 protein sequence have weak similarity with filament or actin-binding proteins. The authors suggested that AIM1 is a good candidate for the putative suppressor of malignant melanoma on chromosome 6 (Trent et al., 1990), possibly exerting its effects through interactions with the cytoskeleton. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20739] "The AIM2 gene at chromosome 1q22 encodes a protein that is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20740] "Absent In Melanoma 2, a protein encoded by the AIM2 gene, is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20741] "RNR1 gene at 13q12 is one of the rRNA genes encoding for ribosomal RNA (rRNA). At the ribosomal RNA gene promoter, transcription initiation by RNA polymerase I allows synthesis of the 45S rRNA precursor molecule, which serves as the molecular precursor for the 18S, 5S and 28S ribosomal RNA components. These mature rRNA molecules associated with other proteins are the structural components of a ribosome. The ribosome, composed of large and small units, is the factory where the polypeptides are produced by interacting with tRNA and mRNA. (From OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                          
[20742] "Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. The RPL8 gene at chromosome 8q24.3 encodes Ribosomal Protein L8, a ribosomal protein that is a component of the 60S subunit. This protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (From LocusLink)"                                                                                                                                                                                                                                                                                                      
[20743] "Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. Ribosomal Protein L8, encoded by the RPL8 gene is a ribosomal protein that is a component of the 60S subunit. This protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (From LocusLink)"                                                                                                                                                                                                                                                                                                                     
[20744] "Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. The RPL19 gene at chromosome 17q11.2-q12 encodes a ribosomal protein that is a component of the large 60S ribosomal subunit. This protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                
[20745] "Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. Ribosomal Protein L19, encoded by the RPL19 gene is a ribosomal protein that is a component of the 60S subunit. This protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (From LocusLink)"                                                                                                                                                                                                                                                                                                                   
[20746] "Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. The RPL29 gene at chromosome 3p21.3-p21.2 encodes a ribosomal protein that is a component of the large 60S ribosomal subunit. This protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin/heparan sulfate. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (From LocusLink)"                                                                                                                                                                                                                                                  
[20747] "Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. Ribosomal Protein L29, encoded by the RPL29 gene, is a ribosomal protein that is a component of the large 60S ribosomal subunit. This protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin/heparan sulfate. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                        
[20748] "The CTBP1 gene at chromosome 4p16 encodes the phosphoprotein C-Terminal Binding Protein 1 (CTBP-1), which is a transcriptional repressor targeting diverse transcription regulators. CTBP1 binds the C-terminus of adenovirus E1A protein. It also interacts with ELK3 and CTIP via their consensus motif. CTBP1 may play a role during cellular proliferation, adenovirus replication and oncogenic transformation. The level of phosphorylation may be regulated during the cell cycle. CTBP1 can form homodimers or heterodimers of CTBP1 and CTBP2. (From LocusLink, Swiss_Prot)"                                                                                                                                                                                                                                                                                                                                                                                                               
[20749] "The phosphoprotein C-Terminal Binding Protein 1 (CTBP-1), encoded by the CTBP1 gene, is a transcriptional repressor targeting diverse transcription regulators. CTBP1 binds the C-terminus of adenovirus E1A protein. It also interacts with ELK3 and CTIP via their consensus motif. CTBP1 may play a role during cellular proliferation, adenovirus replication and oncogenic transformation. The level of phosphorylation may be regulated during the cell cycle.CTBP1 can form homodimers or heterodimers of CTBP1 and CTBP2. (From LocusLink, Swiss_Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20750] "The MSH4 gene at chromosome 1p31 encodes MutS Homolog 4, a 105-kD protein that belongs to the DNA mismatch repair muts family and is involved in meiotic recombination. It is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. The human MSH4 transcripts are detectable only in testis and in ovary with a lower level of expression. (From LocusLink, OMIM, Swiss_Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20751] "MutS Homolog 4, a 105-kD protein encoded by the MSH4 gene, belongs to the DNA mismatch repair muts family and is involved in meiotic recombination. It is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. The human MSH4 transcripts are detectable only in testis and in ovary with a lower level of expression. (From LocusLink, OMOM, Swiss_Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20752] "The Spo11 gene at chromosome 20q13.2-q13.3 encodes SPO11 Meiotic Protein Covalently Bound to DSB-Like (SPO11), a protein that belongs to the TOP6A family. Meiotic recombination and proper segregation of chromosomes are initiated by the formation of double-strand breaks (DSBs) in paired homologs. Located in the nucleus, SPO11 is required for meiotic DSB formation and is covalently linked to the 5-prime end of DSBs during meiosis. SPO11 mediates DNA cleavage with assistance from a large number of other gene products, by a topoisomerase-like transesterase mechanism. SPO11 is highly expressed in testis. Two isoforms, 1 and 2, may be produced by alternative splicing. (From Swiss_Prot, OMIM)"                                                                                                                                                                                                                                                                             
[20753] "The VEGF Gene (PDGF/VEGF Family) at 6p12 encodes seven alternatively spliced isoforms of Vascular Endothelial Growth Factor: VEGF206, VEGF189, VEGF183, VEGF165/VEGF, VEGF148, VEGF145, and VEGF121. This gene is regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoxia, and hypoglycemia. Expression is induced by hypoxia and E2 regulates transcription through a variant upstream ERE. VEGF is a disulfide-linked, 41-45 kD secreted homodimeric glycoprotein that may also heterodimerize with PLGF. VEGF induces endothelial cell proliferation, promotes cell migration, induces vascular permeabilization, and inhibits apoptosis. Neuropilin-1 (VEGF165R), a collapsin/semaphorin receptor that mediates neuronal cell guidance, binds VEGF165 and VEGF145, but not VEGF121. Neuropilin-1 enhances VEGF165 binding to KDR and VEGF165-mediated chemotaxis.  (OMIM, Swiss-Prot, LocusLink and NCI)"                                                                  
[20754] "SPO11 Meiotic Protein Covalently Bound to DSB-Like (SPO11), a protein encoded by the Spo11 gene, belongs to the TOP6A family. Meiotic recombination and proper segregation of chromosomes are initiated by the formation of double-strand breaks (DSBs) in paired homologs. Located in the nucleus, SPO11 is required for meiotic DSB formation and is covalently linked to the 5-prime end of DSBs during meiosis. SPO11 mediates DNA cleavage with assistance from a large number of other proteins, by a topoisomerase-like transesterase mechanism. SPO11 is highly expressed in testis. Two isoforms, 1 and 2, may be produced by alternative splicing. (NCI)"                                                                                                                                                                                                                                                                                                                                 
[20755] "The VEGFC Gene (PDGF/VEGF Family) at 4q34.1-q34.3 encodes Vascular Endothelial Growth Factor C, which may maintain the adult lymphatic endothelium. VEGFC is active in angiogenesis, endothelial cell growth, and blood vessel permeability. It is a high affinity FLT4 ligand and a 23 kD disulfide-linked homodimeric secreted protein that is homologous to VEGF and VEGFB/VRF. The C-terminus has cysteine-rich BR3P repeats. VEGFC can activate lymphatic endothelial VEGFR3 (FLT4) and endothelial cell VEGFR2 (KDR/FLK1) receptor tyrosine kinases. VEGFC undergoes complex proteolytic maturation to generate isoforms with increased activity toward VEGFR3 but only the fully processed form activates VEGFR2. Mature VEGFC is composed mostly of two VEGF homology domains bound by non-covalent interactions. (OMIM, Swiss-Prot, LocusLink and NCI)"                                                                                                                                    
[20756] "Human oncogene VIP Gene (Glucagon-Secretin Family) at 6q26-q27 encodes Vasoactive Intestinal Peptide, an octacosameric gastrointestinal peptide and a neuroendocrine mediator in CNS cholinergic neurons and PNS peptidergic neurons. VIP also affects B- and T cells directly. The 20 Dalton primary translation product (prepro-VIP) contains VIP and 27-amino acid PHM27; VIP and PHM-27 are encoded by adjacent exons. A neuropeptide in the lymphoid microenvironment, VIP has anti-inflammatory action, modulates innate and adaptive immunity, causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis, and relaxes the smooth muscle of trachea, stomach and gall bladder. VIP promotes TH2 differentiation and inhibits TH1 responses by regulating macrophage co-stimulatory signals.  (Omim, Swiss-Prot, LocusLink, and NCI)"                                                                                                 
[20757] "The CCNE1 gene at chromosome 19q12 encodes Cyclin E1, a protein that forms a complex with, and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E1 accumulates at the G1-S phase boundary and phosphorylation by CDK2 triggers its release from CDK2 and degradation. Overexpression of this gene is observed in many tumors, which results in chromosome instability and may contribute to tumorigenesis. Cyclin E1 is associated with and involved in the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two isoforms, E1L and E1S, are produced by alternative splicing and E1S cannot complex with CDK2. Cyclin E1 is highly expressed in testis and placenta with low levels in bronchial epithelial cells. (NCI)"                             
[20758] "Human VIPR1 Gene (GPCR Family 2) at 3p22 encodes Vasoactive Intestinal Peptide Receptor 1. Spanning nearly 22 kb and comprised of thirteen exons (42-1,400 bp long) and twelve introns (0.3-6.1 kb long), VIPR1 generates long and short isoforms by alternative splicing. VIPR1 appears to be expressed in brain, heart, kidney, liver, colonic epithelia, and placenta. The VIP receptor appears to consist of 460 amino acids with 7 transmembrane domains. Distinct subsets of neural, respiratory, gastrointestinal, and immune cells bear high-affinity VIP G protein receptors, capable of activating adenylate cyclase.  (Omim, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                            
[20759] "Cyclin E may function at (cell cycle) START by interacting with CDC28.  Cyclin E complexes with CDK2 in late G1.  Cyclin-dependent kinase activation requires association with cyclins and phosphorylation by CAK, which leads to cell proliferation.  Association of CDK inhibitor with a cyclin/CDK complex inhibits proliferation. CCNE1/CDK2 promotes CDKN1B phosphorylation, elimination of CDKN1B, and G1/S progression of the cell cycle.  Enhanced CDKN1B inhibitory function arrests proliferation.  Cyclin E is bound directly by AGO, which probably targets its ubiquitin-mediated degradation.  (from OMIM 123837 and NCI)"                                                                                                                                                                                                                                                                                                                                                            
[20760] "APEX Nuclease, encoded by the APE1 gene, is a ubiquitous monomeric apurinic/apyrimidinic DNA repair endonuclease (AP/EXOA family) with 3-prime-, 5-prime-exonuclease, DNA 3-prime repair diesterase, and DNA 3-prime-phosphatase activities. The constitutive gene contains five exons spanning 2.64 kb; the first exon is untranslated. The 0.5 kb upstream DNA contains only a possible CCAAT box and no other regulatory sites or a TATA box. A potent activator of p53 protein, APE1 may protect against cell lethality and suppress mutations produced by spontaneous hydrolysis, by chemicals and radiation, or by DNA glycosylases that remove abnormal bases from DNA. Abasic sites that can block DNA replication and cause mutations must be corrected to restore genetic integrity. A repressor of the PTH gene, APE binds to promoter negative Ca(2+)-response elements, which are also present in the APE1 gene. (NCI)"                                                                
[20761] "Human oncogene WHSC1 Gene at 4p16.3 partially resides in the 165 kb WHS critical region. The 25-exon WHSC1 gene transcript undergoes complex alternative splicing and differential polyadenylation. It encodes a 136 kD Wolf-Hirschhorn Syndrome Candidate 1 Protein containing a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. WHSC1 is preferentially expressed in rapidly growing embryonic tissues, in a pattern corresponding to affected organs in WHS patients. The nature of the protein motifs, the expression pattern, and its mapping to the critical region suggest that WHSC1 is a good candidate responsible for many of the phenotypic features of WHS; a malformation syndrome associated with hemizygous deletion of the chromosome 4 distal short arm.  (Omim, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                              
[20762] "Human oncogene WISP2 Gene at 20q12-q13.1 constitutes one of three genes - WISP1, WISP2, and WISP3 - that encode factors downstream in the WNT signaling pathway relevant to malignant transformation. WISP2 encodes a 250-amino acid WNT1 Inducible Signaling Pathway Protein 2. Expression is reduced in 79% of human colon tumors; WISP1 and WISP3 are over expressed in colon tumors.  (Omim, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20763] "Human oncogene WISP3 Gene (CCN Family) at 6q22-q23 constitutes one of three genes - WISP1, WISP2, and WISP3 - that encode factors downstream in the WNT signaling pathway relevant to malignant transformation. WISP3 resides 18 Mb proximal to CTGF at 6q23.1 and 23 Mb proximal to MYB at 6q22. CCN genes encode cell- and tissue-specific cysteine-rich secreted proteins with roles in cell growth and differentiation. WISP3 encodes a 354-amino acid WNT1 Inducible Signaling Pathway Protein 3 essential for skeletal growth and cartilage homeostasis; mutations are associated with progressive pseudorheumatoid dysplasia. WISP1 and WISP3 are over expressed in colon tumors; WISP2 expression is reduced.  (Omim, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                      
[20764] "Human oncogene WNT2B Gene (WNT Family) at 1p13 encodes a novel 372-amino acid WNT2B Protein homolog of Xenopus Xwnt2. WNT2B is expressed as a 2.5-kb mRNA in fetal brain, lung, and kidney, and in a variety of adult tissues. Two isoforms are produced by alternative splicing. Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine, and colon. Isoform 2 is expressed in fetal brain, lung, and kidney, and in adult brain and testis. Highly-conserved WNT genes encode 350-400 amino acid, cysteine-rich, short-range glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. (NCI)"                                                                                                                                                                                                
[20765] "Highly-conserved WNT genes encode 350-400 amino acid, cysteine-rich, short-range glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. The WNT6 Gene (WNT Family) at 2q35 encodes WNT6 Protein, which contains conserved residues, two N-linked glycosylation sites, an N-terminal signal peptide, and an RGD motif. A 2 kb transcript is expressed in brain, testis, placenta, and spleen. It shares 47.4% sequence identity with WNT1. Aberrant WNT6 expression may contribute to tumorigenesis and WNT6 is overexpressed in HeLa, cervical cancer, and colorectal cancer cell lines. (OMIM, Swiss-Prot, LocusLink and NCI)"                                                                                                                                                                                                            
[20766] "Human WNT10A Gene (WNT Family) encodes WNT10A Protein, a putative ligand for a member(s) of the frizzled family of seven transmembrane receptors. WNT10A may be a signaling molecule in CNS development. Highly-conserved WNT genes encode 350-400 amino acid, cysteine-rich, short-range signaling glycoproteins involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues.  (Omim, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20767] "Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. (From LocusLink 27301)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20768] "Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. Apurinic/Apyrimidinic Endonuclease 2, a protein encoded by the APEXL2 gene, has a weak class II AP endonuclease activity. Most of this protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). (From LocusLink 27301)"                                                                                                                                                                                                                                        
[20769] "Human WNT11 Gene (WNT Family) at 11q13.5 contains five exons encoding the WNT11 Protein expressed in fetal ureteric bud tips, perichondrium, lung mesenchyme, urorectal septum, urogenital folds, labioscrotal swellings, and adrenal gland cortex as well as adult heart, liver, skeletal muscle, and pancreas. Highly-conserved WNT genes encode 350-400 amino acid, cysteine-rich, short-range glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. WNT11 activity may drive vertebrate gastrulation; the WNT11 homolog of zebrafish (slb) is required for gastrulation. WNT11 also appears to be required for heart formation in higher vertebrates, mediated by noncanonical WNT-Dishevelled signaling, independent of beta-catenin, and involving PKC and JNK.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                            
[20770] "The WNT14 gene (WNT Family) at 1q42 encode a 4.4 kb transcript in adult skeletal muscle, heart, lung, pancreas, spleen, ovary, and placenta, and in fetal brain and lung. The WNT14 gene encodes WNT14 Protein, which contains an N-linked glycosylation site. WNT14 shows 54% identity to human WNT15. WNT14 and WNT15 are most related to Drosophila Wnt4 and hagfish Wnt9 and may share a common ancestry. Highly-conserved WNT genes encode 350-400 amino acid, cysteine-rich, short-range glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. Wnt14 initiates synovial joint formation in chick limb and is expressed in joint-forming regions where it induces the first steps of joint formation.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                       
[20771] "Human WSX1 Gene at 19p13.11 encodes WSX1 Class I Cytokine Receptor, which is most homologous to IL12RB2 and 62% identical to mouse Tccr. A 3.5 kb transcript is seen in PBL, thymus, spleen, and lung. Highest expression occurs in CD4+ T cells and natural killer cells. Among CD4+ T cells, expression is highest in Th0 cells, with reduced expression in Th1 and Th2 cells. The deduced 636-amino acid protein exhibits a single transmembrane domain, a WSX signature motif, seven potential extracellular N-glycosylation sites, and an intracellular BOX1 motif.  (Omim, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                   
[20772] "Human XCR1 Gene (GPCR Family 1) at 3p21.3-p21.1 encodes within a single exon a 333-amino acid seven transmembrane protein, Chemokine (C Motif) XC Receptor 1, most closely related to RBS11 and MIP1-alpha/RANTES receptor. Strong expression of a 5 kb transcript occurs in placenta, spleen, and thymus. GPR5 is a receptor for chemokines XCL1 (SCYC1) and XCL2 (SCYC2). Cells expressing GPR5 mobilize intracellular calcium and migrate in response to SCYC1 and SCYC2. Migration is suppressed by pertussis toxin, indicating that the receptor is coupled to a G-alpha protein.  (Omim, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                     
[20773] "Human YARS Gene (Class-I Aminoacyl-tRNA Synthetase Family) at 1p34.3 encodes a 528-amino acid Tyrosyl-tRNA Synthetase. Likely to be among the first proteins to appear in evolution, amino acyl-tRNA synthetases catalyze tRNA amino acylation by their cognate amino acid. Under apoptotic conditions, tyrosyl-tRNA synthetase may be secreted and cleaved into an N-terminal IL8-like cytokine fragment that harbors the catalytic site and a C-terminal EMAP II-like cytokine fragment.  (Omim, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20774] "Human YWHAQ Gene (14-3-3 Family) on chromosome 2 encodes a cytoplasmic homodimeric YWHAQ Protein. 14-3-3 proteins are localized in neurons and are axonally transported to the nerve terminals. 14-3-3 proteins may be present in other tissues as well. A probable multifunctional regulator of cell signaling processes, YWHAQ Protein strongly activates PKC as well as tyrosine and tryptophan hydroxylases in the presence of Ca(2+)/calmodulin-dependent protein kinase II.  (Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20775] "Ataxia Telangiectasia and Rad3 Related Protein (ATR), encoded by the ATR gene, is a member of the PIK (phosphatidylinositol kinase)-related kinase family that are high molecular weight kinases involved in cell cycle progression, DNA recombination, and the detection of DNA damage. ATR is essential for the viability of human somatic cells. ATR and ATRIP (ATR-interacting protein) are mutually dependent partners in cell cycle checkpoint signaling pathways - ATR phosphorylates ATRIP that regulates ATR expression and is an essential component of the DNA damage checkpoint pathway. ATR phosphorylates checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. ATR may be particularly essential in the early embryo to sense incomplete DNA replication and prevent mitotic catastrophe. (From OMIM, LocusLink and NCI)"                                                                                                          
[20776] "Human oncogene ZFP36L2 Gene at 2p22.3-p21 encodes a putative nuclear regulatory Zinc Finger Protein 36 C3H Type-Like 2 containing two C3H1-type zinc fingers and involved in growth factor response.  (Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20777] "Human oncogene ZNF151 Gene (Kruppel Family) at 1p36.2-p36.1 encodes Zinc Finger Protein 151, highly expressed in brain and muscle and containing an N-terminal BTB/POZ domain and thirteen C2H2 zinc finger domains connected by conserved H/C links. Located mainly in the cytosol, ZNF151 exerts a potent growth arrest function that may involve transcriptional activation of growth inhibitory genes; cells progress into S phase but not into mitosis. ZNF151 is regulated by association with microtubules and may activate gene transcription in response to changes in the cytoskeleton. ZNF151 can transactivate the cyclin D1 (CCND1) promoter and activates alpha-2 integrin and LDLR transcription. ZNF151 interacts specifically with the HLH domain of MYC and NMYC. MYC interaction inhibits ZNF151 transactivation, induces ZNF151 nuclear sequestration, and overcomes ZNF151-induced growth arrest. (OMIM, Swiss-Prot, LocusLink and NCI)"                                       
[20778] "Human oncogene ZNF217 Gene (Kruppel Family) at 20q13.2 encodes Zinc Finger Protein 217 isoforms, widely expressed transcription factors of 1,062 and 1,108 amino acids having a DNA-binding domain (eight C2H2-type zinc fingers) and a proline-rich transcription activation domain. The gene is over expressed in cell lines and in tumors in which it is amplified.  (Omim, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20779] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20780] "Encoded by human WSX1 Gene, WSX1 Class I Cytokine Receptor, most homologous to IL12RB2, is seen in PBL, thymus, spleen, and lung. Highest expression occurs in CD4+ T cells and natural killer cells. Among CD4+ T cells, expression is highest in Th0 cells, with reduced expression in Th1 and Th2 cells. The 636-amino acid 69.5 kD protein exhibits a single transmembrane domain, a WSX signature motif, seven potential extracellular N-glycosylation sites, and an intracellular BOX1 motif.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20781] "Encoded by human YARS Gene, the 528-amino acid Tyrosyl-tRNA Synthetase polypeptide belongs to the Class-I Aminoacyl-tRNA Synthetase Family. Likely to be among the first proteins to appear in evolution, amino acyl-tRNA synthetases catalyze tRNA amino acylation by their cognate amino acid. Under apoptotic conditions, tyrosyl-tRNA synthetase may be secreted and cleaved into an N-terminal IL8-like cytokine fragment that harbors the catalytic site and a C-terminal EMAP II-like cytokine fragment.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20782] "DNA excision repair protein ERCC-1, encoded by the ERCC1 gene, is a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Its C-terminal is essential for enzymatic activity and the central region is involved in protein-protein interactions. The ERCC1 gene is involved in UV cross-link repair and nucleotide excision repair (NER). With p53 monitoring DNA damage, either XPA loads and possibly orients an incision complex, containing ERCC1 and other repair factors, to the site of DNA damage or XPA, ERCC1, and ERCC4 proteins form a ternary complex that participates in both damage recognition and incision activities. In the absence of DNA damage, the complex moved freely through the nucleus. Ultraviolet light-induced DNA damage causes a transient immobilization of ERCC1/XPF to engage the complex in a single repair event. Afterwards, the complex regains mobility. (From OMIM 126380 and NCI)"                         
[20783] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20784] "Encoded by human TRE2 Gene, some evidence suggests that human Ubiquitin Specific Protease 6 (C19 Peptidase Family) may actually be encoded by separate elements on chromosomes 5, 18, and 17. The 1089-amino acid 122 kD hydrophilic protein contains two charge clusters, suggesting nucleic acid-binding properties. Ubiquitin Specific Protease 6 appears to have ATP-independent isopeptidase activity, cleaving at the carboxyl terminus of ubiquitin.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20785] "Encoded by human USP8 Gene (C19 Peptidase Family), Ubiquitin Specific Protease 8 is a deubiquitinating enzyme related to the TRE2 oncogene product that cleaves at the carboxyl terminus of ubiquitin. In chronic myeloproliferative disorder, an oncogenic fusion of p85-beta occurs with the carboxyl end of USP8.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20786] "Encoded by human VEGFC Gene (PDGF/VEGF Family), VEGFC is expressed in spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon, and small intestine, as well as fetal liver, lung, and kidney. Active in angiogenesis, endothelial growth, and vascular permeability, VEGFC may maintain adult lymphatic endothelium. A FLT4 ligand, VEGFC is a 419-amino acid 47 kD (precursor) disulfide-linked homodimeric secreted polypeptide with C-terminal cysteine-rich BR3P repeats and similar to VEGF and VEGFB/VRF. VEGFC can also activate endothelial VEGFR2 (KDR/FLK1). VEGFC proteolytic maturation generates isoforms with increased VEGFR3 activity; fully processed VEGFC activates VEGFR2. Mature VEGFC is mostly composed of two VEGF homology domains bound by non-covalent interactions.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                
[20787] "Encoded by human oncogene VIP Gene (Glucagon-Secretin Family), VIP is a 170-amino acid 19 kD (precursor) octacosameric gastrointestinal peptide and a neuroendocrine mediator in CNS cholinergic neurons and PNS peptidergic neurons. VIP also affects B- and T cells directly. Prepro-VIP contains VIP and 27-amino acid PHM27. A neuropeptide in the lymphoid microenvironment, VIP has anti-inflammatory action, modulates innate and adaptive immunity, causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis, and relaxes the smooth muscle of trachea, stomach and gall bladder. VIP promotes TH2 differentiation and inhibits TH1 responses by regulating macrophage co-stimulatory signals.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                           
[20788] "Encoded by human VIPR1 Gene (GPCR Family 2), Vasoactive Intestinal Peptide Receptor 1 appears to be expressed in brain, heart, kidney, liver, colonic epithelia, and placenta. The 457-amino acid 51.5 kD (precursor) G protein-coupled receptor contains seven transmembrane domains. Distinct subsets of neural, respiratory, gastrointestinal, and immune cells bear high-affinity VIP G protein receptors, capable of activating adenylate cyclase.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20789] "Encoded by human VAV3 Gene (VAV Family), the 847-amino acid VAV-3 Protein exhibits similarity to VAV1 and VAV2. Alpha and beta isoforms are expressed in peripheral blood lymphocytes, spleen, brain, thymus, heart, kidney, liver, placenta, and lung. VAV3 contains DBL and pleckstrin homology domains, a calponin homology region, an acidic motif, a DAG binding domain, two SH3 regions, and a SH2 domain. VAV3.1 Protein variant contains only the C-terminal SH3-SH2-SH3 region. Regulating the actin cytoskeleton and transcription, VAV3 acts as a GEF on RHOA, RHOG, and RAC1. VAV1, VAV2, and VAV3 respond to similar cell surface receptor tyrosine kinases. VAV3 is rapidly phosphorylated on TCR or EGFR activation. VAV1 and VAV3 enhance NFKB-dependent transcription. Integrin-induced phosphorylation requires SYK.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                     
[20790] "Encoded by human oncogene WISP2 Gene, the 250-amino acid WNT1 Inducible Signaling Pathway Protein 2 constitutes - with WISP1 and WISP3 - one of three factors downstream in the WNT signaling pathway relevant to malignant transformation. WISP2 expression is reduced in 79% of human colon tumors; WISP1 and WISP3 are over expressed in colon tumors.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20791] "Encoded by human ERCC2 Gene (RAD3/XPD Family), 760-aa 87-kDa nuclear DNA Excision Repair Protein ERCC2 is an ATP-dependent 5 prime-3 prime DNA helicase and one of six integral subunits of the basal transcription factor BTF2/TFIIH complex. Recruited by transcription preinitiation or DNA damage recognition complexes, ERCC2 is involved in RNA polymerase II transcription, transcription-coupled nucleotide excision DNA repair, and cell cycle regulation. ERCC2/MAT1 anchors CAK complex to the TFIIH complex. CAK inhibits ERCC2 helicase activity; overcome by binding TFIIH subunit p44, which stimulates helicase activity. ERCC2 defects result in XPD, XPD/CS, TTD, and COFS Syndrome. (NCI)"                                                                                                                                                                                                                                                                                       
[20792] "Encoded by human oncogene WISP3 Gene (CCN Family), the 354-amino acid 39.3 kD WNT1 Inducible Signaling Pathway Protein 3 constitutes - with WISP1 and WISP2 - one of three factors downstream in the WNT signaling pathway relevant to malignant transformation. CCN proteins are cell- and tissue-specific cysteine-rich secreted factors with roles in cell growth and differentiation. WISP3 protein is essential for skeletal growth and cartilage homeostasis; mutations are associated with progressive pseudorheumatoid dysplasia. WISP3 is over expressed in colon tumors.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                         
[20793] "Encoded by human oncogene WNT2B Gene (WNT Family), the novel 391-amino acid 43.8 kD (precursor) WNT2B Protein is a homolog of Xenopus Xwnt2 and expressed in fetal brain, lung, and kidney, as well as in a variety of adult tissues.  Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine, and colon.  Isoform 2 is expressed in fetal brain, lung, and kidney, and in adult brain and testis.  Highly-conserved, 350-400 amino acid WNT glycoproteins constitute cysteine-rich, short-range ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. (NCI)"                                                                                                                                                                                                                                          
[20794] "Encoded by human WNT6 Gene (WNT Family), WNT6 Protein is expressed in brain, testis, placenta, and spleen. In mouse embryos, Wnt6 is expressed panectodermally, in somites, in limb bud, and in the reproductive system. In adult mice, Wnt6 is expressed in the mammary gland. WNT6 encodes a 365-amino acid 39.7 kD (precursor) peptide containing conserved residues, two N-linked glycosylation sites, an N-terminal signal peptide, and an RGD motif. Highly-conserved, 350-400 amino acid WNT glycoproteins constitute cysteine-rich, short-range ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                 
[20795] "Encoded by human WNT10A Gene (WNT Family), 417-amino acid 46 kD (precursor) WNT10A Protein is a putative ligand for a member(s) of the frizzled family of seven transmembrane receptors and may be a signaling molecule in CNS development. Highly-conserved, 350-400 amino acid WNT glycoproteins constitute cysteine-rich, short-range ligands involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20796] "Encoded by human WNT11 Gene (WNT Family), the 354-amino acid 39 kD (precursor) WNT11 protein is expressed in fetal ureteric bud tips, perichondrium, lung mesenchyme, urorectal septum, urogenital folds, labioscrotal swellings, and adrenal cortex as well as adult heart, liver, skeletal muscle, and pancreas. Highly-conserved, 350-400 amino acid WNT glycoproteins constitute cysteine-rich, short-range ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. WNT11 may drive vertebrate gastrulation; homolog slb (zebrafish) is required for gastrulation. WNT11 may be required for vertebrate heart formation, mediated by noncanonical WNT-Dishevelled signaling; independent of beta-catenin and involving PKC and JNK.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                         
[20797] "DNA Excision Repair Protein ERCC-3, encoded by the ERCC3 gene, is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. This protein is also the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. (from LocusLink 2071 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20798] "Encoded by human WNT14 Gene (WNT Family), the 365-amino acid 40 kD (precursor) WNT14 Protein is seen in adult skeletal muscle, heart, lung, pancreas, spleen, ovary, and placenta, and in fetal brain and lung. WNT14 is most related to Drosophila Wnt4. Highly-conserved, 350-400 amino acid WNT glycoproteins constitute cysteine-rich, short-range ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. Wnt14 initiates synovial joint formation in chick limb and is expressed in joint-forming regions where it induces the first steps of joint formation.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                            
[20799] "Encoded by human oncogene WHSC1 Gene, 1365-amino acid 152 kD Wolf-Hirschhorn Syndrome Candidate 1 Protein contains a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. WHSC1 is preferentially expressed in rapidly growing embryonic tissues, in a pattern corresponding to affected organs in WHS patients. The nature of the protein motifs and expression pattern suggest that WHSC1 is a good candidate responsible for many of the phenotypic features of WHS; a malformation syndrome associated with hemizygous deletion of the chromosome 4 distal short arm.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                    
[20800] "Encoded by human YWHAQ Gene, 245-amino acid 27.8 kD YWHAQ Protein is a cytoplasmic homodimeric 14-3-3 family protein. 14-3-3 proteins are localized in neurons, and are axonally transported to the nerve terminals. 14-3-3 proteins may be present in other tissues as well. A probable multifunctional regulator of cell signaling processes, YWHAQ Protein strongly activates PKC and activates tyrosine and tryptophan hydroxylases in the presence of Ca(2+)/calmodulin-dependent protein kinase II.  (Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20801] "Encoded by human oncogene ZFP36L2 Gene, 492-amino acid 50.9 kD Zinc Finger Protein 36 C3H Type-Like 2 is a putative nuclear regulatory protein containing two C3H1-type zinc fingers and involved in growth factor response.  (Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20802] "Encoded by human oncogene ZNF151 Gene (Kruppel Family) and highly expressed in brain and muscle, 803-amino acid 88 kD Zinc Finger Protein 151, similar to Z13 (mouse), contains an N-terminal BTB/POZ domain and thirteen C2H2 zinc finger domains connected by conserved H/C links. Predominantly cytoplasmic, ZNF151 may arrest growth (S/M) by activation of growth inhibitory genes. Associated with microtubules, ZNF151 may activate gene transcription in response to cytoskeletal changes. ZNF151 can transactivate cyclin D1 (CCND1,) alpha-2 integrin, and LDLR. ZNF151 interacts specifically with the HLH domain of MYC and NMYC. MYC interaction inhibits ZNF151 transactivation, induces ZNF151 nuclear sequestration, and overcomes ZNF151-induced growth arrest.  (OMIM, Swiss-Prot, and NCI)"                                                                                                                                                                                      
[20803] "Encoded by human oncogene ZNF217 Gene (Kruppel Family), 1048-amino acid 115 kD Zinc Finger Protein 217 is a widely expressed transcription factor having a DNA-binding domain (eight C2H2-type zinc fingers) and a proline-rich transcription activation domain. ZNF217 is over expressed in cell lines and in tumors in which the gene is amplified.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20804] "DNA Excision Repair Protein ERCC-4, encoded by the ERCC4 gene, is a DNA repair protein. Nucleotide excision repair (NER) involves incision of a DNA strand on each side of a lesion. The two incisions made during NER are catalyzed by separate DNA endonucleases. A tight protein complex formed between ERCC4 and ERCC1 acts as a structure-specific endonuclease for the 5-prime incision during repair. Without DNA damage, this complex moves freely through the nucleus. Ultraviolet light-induced DNA damage causes a transient immobilization of ERCC4/ERCC1 due to engagement of the complex in a single repair event after assembly of individual nucleotide excision repair factors at sites of DNA damage in a distributive fashion. Causative mutations in the ERCC4 gene and strongly reduced levels of encoded protein can be identified in patients with xeroderma pigmentosum type F. (From OMIM and NCI)"                                                                        
[20805] "XPG-Complementing Protein, encoded by the ERCC5 gene is involved in transcription-coupled repair of UV-induced DNA damage. It is a single-strand specific DNA endonuclease that nicks damaged DNA 3-prime to the lesion in nucleotide excision repair as a result of the combined action of the XPB helicase and XPD helicase following sequential assembly of repair proteins at the DNA damage site. In addition, it associates with CSA, CSB, or both proteins at the transcriptional pause sites to facilitate the resumption of transcript elongation without aborting the associated nascent transcript by pushing the stalled RNA polymerase II either forward or backward not only from the damaged site but also from some natural transcription pause sites. Mutational inactivation of XPG causes Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. (from OMIM 133530, LocusLink 2073 and NCI)"                                      
[20806] "Excision Repair Protein ERCC-6 (ERCC6), encoded by the ERCC6 gene (SNF2/RAD54 Family), is a putative DNA or RNA unwinding helicase involved in transcription-coupled excision repair. This protein specifically interacts with CSA proteins and with p44, a subunit of the RNA Polymerase II basal transcription factor TFIIH. It has DNA-dependent ATP-stimulated ATPase activity that may have a role in the displacement of stalled RNA Polymerase II from sites of DNA lesion and in recruitment of a DNA repair component. ERCC6 inhibits fragility of RNU1, RNU2, and RN5S genes. p53 interacts with ERCC6 and activation of p53 inhibits ERCC6, stalling transcription complexes and blocking local chromatin condensation. Defects in ERCC6 are the cause of Cockayne's syndrome type B (CSB). (NCI)"                                                                                                                                                                                       
[20807] "Exonuclease 1, encoded by the EXO1 gene, is a 88-kD protein with 5-prime to 3-prime double strand DNA exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different protein isoforms, a and b. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20808] "DNA ligase IV (LIG4), a 96-kD protein encoded by the LIG4 gene, belongs to the ATP-dependent DNA ligase family. LIG4 efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is the activity responsible for the ligation step in nonhomologous DNA end joining and in V(D)J recombination. Defects in LIG4 are the cause of LIG4 syndrome. (OMIM 601837)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20809] "MLH1 protein is a DNA-binding, DNA-mismatch repair protein, of the MutL/HexB family, that dimerizes with PMS2 or MLH3.  MLH1 is part of the multi-subunit BASC repair complex containing ATM, BLM, MSH2, MSH6, BRCA1, the RAD50/MRE11/NBS1 complex, and the RFC1/RFC2/RFC4 complex.  MLH1 is homologous to MutL, which hydrolyzes ATP.  (from OMIM 120436 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[20810] "DNA Mismatch Repair Protein MLH3, encoded by the MLH3 gene, is ubiquitously expressed in various tissues and two isoforms are produced by alternative splicing. MLH3 interacts with MLH1 and shares the same interacting region on MLH1 with PMS1 and PMS2. The balance of these three competing MLH1 partners might be important in the repair of mismatches in DNA. Malfunction of the mismatch repair system results in a mutator phenotype, which is manifested as microsatellite instability (MSI). MSI is often divided into 2 forms: MSI-high (MSI-H) and MSI-low (MSI-L), based quantitatively on the observed frequency of genomic mutations. An appreciable frequency of somatic MLH3 mutations in MSI-H tumors is consistent with a possible role for this gene in the progression of colorectal cancer tumorigenesis. Germline mutations of the MLH3 gene may also play a role in hereditary nonpolyposis colorectal cancer (NCI)"                                                      
[20811] "Alterations in MSH2 Protein are associated with DNA instability from defective repair of DNA replication errors that create mismatched nucleotides. MSH2 contains a highly conserved helix-turn-helix domain associated with an adenine nucleotide and magnesium binding motif and ATPase activity that regulates mismatch binding as a molecular switch. MSH2 protein binds DNA containing mismatches up to 14 nucleotides long. ADP-bound MSH/MSH6 binds mismatched nucleotides and ATP hydrolysis results in mismatch binding, while ADP/ATP exchange results in mismatch dissociation. MSH2 is part of the large multi-subunit BASC complex, which may sense abnormal DNA structures and/or regulate post-replication repair. MSH2 protein also interacts with G/T binding protein. MSH2 is a cloned gene for Hereditary Non-Polyposis Colon Cancer that causes colon cancer, endometrial cancer, and stomach cancer. (from OMIM and NCI)"                                                      
[20812] "DNA Mismatch Repair Protein MSH3, encoded by the MSH3 gene (MutS family), is a 127-kD mismatch repair (MMR) protein. Mismatch recognition in human cells is mediated by two heterodimers, MutS alpha (MSH2/MSH6) and MutS beta (MSH2/MSH3) with different mispair recognition properties and abilities. Both participate in repair of a dinucleotide insertion-deletion heterology but only MutS alpha restores base-base mismatch repair and shoulders primary responsibility for mismatch correction during replication. Predisposition to intestinal cancer requires loss of function of both Msh2/Msh6 and Msh2/Msh3 but Msh3 deficiency alone does not cause cancer predisposition. Mismatch repair deficiency can arise not only through mutation or transcriptional silencing of a mismatch repair gene, but also as a result of imbalance in the relative amounts of the MSH3 and MSH6 proteins because MutS alpha and MutS beta share a common component, MSH2. (NCI)"                     
[20813] "The G/T Binding Protein (GTBP), encoded by the MSH6 gene, forms Mismatch-Binding Factor with MSH2. Associated with colon, endometrial, and stomach cancers, the MSH6 Gene is a cloned gene for Hereditary Non-Polyposis Colon Cancer. GTBP contains a PWWP domain, binds to G/T mismatches, is required for base/base and single-nucleotide insertion-deletion repairs, and increases the proficiency of two-four nucleotide insertion-deletion repair. ADP-bound MSH2/MSH6 binds to mismatched DNA, provoking ADP/ATP exchange and MSH2/MSH6 migration along the DNA backbone. DNA-bound, ATP-bound MSH2/MSH6 activates the repair machinery. MSH6 is part of the multisubunit BASC complex, which may sense abnormal DNA structures and regulate postreplication repair. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. (From SWISS-PROT, OMIM, and NCI)"                                                                          
[20814] "Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas, human TRAF6 Gene (TRAF Family) encodes 522-aa 60-kDa oligomeric adapter protein and signal transducer TNF Receptor-Associated Factor 6, containing a MATH domain, a RING-type zinc finger, 2 TRAF-type zinc fingers, and a coiled coil domain that mediates homo- and hetero-oligomerization. The MATH/TRAF domain binds to receptor cytoplasmic domains. In mediating TNFR and Toll/IL-1 family signal transduction to diverse pathways, TRAF6 interacts with TNFRSF5, -11A, -11B, -16 and -17, SRC, PKC zeta, IRAK1, -2, and -3, RIPK2, MAP3K1, -5, and -14, CSK, TRIP, TRAF, TTRAP, PELI1, PELI2, and PELI3. TRAF6 activates IKK in the NF-kappa B pathway in response to proinflammatory cytokines and is involved in the IL-1 signaling pathway via MYD88 and IRAK kinases. (NCI)"                                                                                                                    
[20815] "Encodes a novel cancer/testis antigen overexpressed in melanoma cell lines and malignant melanoma. (from Anticancer Res 2000;20:4147-51)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20816] "The causation or production of tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20817] "Human TRC8 Gene encodes Multiple Membrane Spanning Receptor TRC8, a multi-membrane spanning ER protein containing a RING-H2 zinc finger with ubiquitin ligase activity. TRC8 may interact with tumor suppressor protein VHL as well as with COPS5/JAB1, responsible for degradation of tumor suppressor CDKN1B/p27KIP. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[20818] "Expressed as a 2-kb transcript in T cells (not B cells or monocytes) of the thymus, spleen, lymph nodes, and peripheral leukocytes, 32-kb 6-exon human TRIM Gene encodes 186-aa 29/30-kD disulfide-linked dimeric type III transmembrane adaptor phosphoprotein T-Cell Receptor Interacting Molecule, containing an 8-aa extracellular domain (includes a Cys residue), a 19-aa transmembrane region and an intracellular domain with 4 potential phosphorylation sites likely involved in SH2-mediated interactions with signaling proteins. Associated with CD3E and CD3Z, TRIM modulates the TCR-CD3 complex in T lymphocytes. After T-cell activation, TRIM is tyrosine phosphorylated by Src kinases and associates with PIK3R1. (NCI)"                                                                                                                                                                                                                                                        
[20819] "Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney, and lung, human TRIO Gene (Ser/Thr Kinase Family) encodes 3038-aa 342-kDa serine phosphorylated Triple Functional Domain Protein, containing a Ser/Thr kinase domain, 2 DH domains, a CRAL-TRIO domain, an Ig-like C2-type domain, 2 PH domains, an SH3 domain, and 4 spectrin repeats. The N-terminal DBL(DH)/GEF domain catalyzes RAC1 GDP/GTP exchange, leading to JUN kinase activation and membrane ruffling. The second DBL(DH)/GEF domain catalyzes RHOA GDP/GTP exchange, inducing stress fiber formation. Interacting with the cytoplasmic region of LAR tyrosine phosphatase, TRIO may coordinate cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth. (NCI)"                                                                                                                                                                                                  
[20820] "The protein 8-Oxoguanine DNA Glycosylase, encoded by the OGG1 gene, is an enzyme in base excision repair. OGG1 incises DNA at 8-oxoguanine residues and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-n-methylformamidopyrimidine (FAPY) from damaged DNA. OGG1 also has activities of beta-lyase that nicks DNA 3-prime to the lesion and endonuclease that cleaves DNA near apurinic or apyrimidinic sites to products with 5-prime-phosphate. Alternative splicing of the C-terminal region of the OGG1 gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common (1a/alpha, 1b, 1c, 2a/beta, 2b, 2c, 2d and 2e) and 1a is the prevalent form. OGG1 is ubiquitous and located in nucleus (isoform 1a) and mitochondria (isoform 2a). Defects in OGG1 are associated with tumor formation."             
[20821] "Expressed in skeletal muscle, heart, placenta, pancreas, lung, liver, kidney, and brain, human TRIP10 Gene encodes 545-aa 63-kDa Thyroid Hormone Receptor Interactor 10, containing an SH3 domain, an FCH domain, and similar to the non-kinase domains of FER and FES/FPS tyrosine kinases. Likely involved in CDC42 and WASP-dependent signal transduction, TRIP10 binds to activated CDC42 and may link CDC42 signaling with regulation of the actin cytoskeleton. TRIP10 specifically interacts (TH-dependent) with the ligand-binding domain of TR. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20822] "DNA Mismatch Repair Protein PMS1, encoded by the PMS1 gene, is implicated, with MSH2 and MLH1, in mismatch repair of dinucleotide and trinucleotide sequences. A cloned gene for Hereditary Non-Polyposis Colon Cancer, the PMS1 Gene (MUTL/HEXB family) at 2q31-q33 is associated with colon, endometrial, and stomach cancers. Human PMSL genes exhibit homology to bacterial mutL genes and yeast PMS1 gene. (From SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20823] "Encoded by human ACRBP Gene, 540-amino acid 61 kD Acrosin Binding Protein (CT Family) is similar to proacrosin binding protein sp32 precursor found in pig, mouse, and guinea pig.  Expressed in normal testis only, but detected in a range of tumor types such as bladder, breast, lung, liver, and colon, this immunogenic protein is located in the sperm acrosome and may package and condense proacrosin in the acrosomal matrix.  (from SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20824] "Associated with colon, endometrial, and stomach cancers, DNA Mismatch Repair Protein PMS2, a 97-kD protein encoded by the ubiquitously expressed PMS2 Gene (MUTL/HEXB family) is involved with MSH2 and MLH1 in mismatch repair of dinucleotide and trinucleotide sequences. PMS2 is part of the BASC genome surveillance complex. MSH2 and MLH1 interact with PMS1, PMS2, and MSH6. Essential for repair of replication slippage errors, PMS2 is a cloned gene for Turcot syndrome and Hereditary Non-Polyposis Colon Cancer. Transcribed from the opposite strand, JTV1 overlaps PMS2. (From SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                          
[20825] "Relative; a person related by blood or marriage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20826] "Any relative who is one meiosis away from a particular individual in a family; a relative with whom one half of an individual's genes is shared (i.e., parent, sibling, offspring) (from Genetics Home Reference glossary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20827] "Encoded by human AGR2 Gene, soluble Anterior Gradient 2 Homologue Protein is 47% identical to the cement gland anterior gradient protein (Xenopus laevis) and 91% identical to the mouse protein.  Strongest expression is seen in the lung; weaker expression in the pancreas and other tissues.  Strong expression is also detected in trachea, stomach, colon, prostate, and small intestine.  (from OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20828] "Protein Kinase, DNA-Activated, Catalytic Subunit (PRKDC), encoded by the PRKDC gene, is a nuclear protein serine/threonine kinase of a multiprotein complex DNA-dependent protein kinase (DNA-PK). Two protein isoforms are produced by alternative splicing and binds DNA for catalysis. PRKDC relies on the heterodimer Ku70/Ku80 autoantigen, the DNA-binding DNA-PK component, to direct it to DNA double-stranded breaks for other discontinuities in the DNA double helix and trigger its kinase activity. PRKDC is critical for repair of DNA double strand breaks via the nonhomologous DNA end joining, telomere maintenance via telomere capping, innate immune response via V(D)J recombination (where V is variable, D is diversity, and J is joining) as well as transcriptional regulation via p53, the site-specific recombination process in developing B and T lymphocytes to generate the variable regions of immunoglobulin and T cell receptor genes."                          
[20829] "Encoded by human ANP32C Gene, 234-amino acid 27 kD PP32R1 Protein (PP32 Family) shares approximately 90% amino acid sequence identity with tumor suppressor PP32 and PP32R2.  PP32 can inhibit several types of cancers, including prostate and breast cancers.  PP32R1 and PP32R2 are tumorigenic.  Amino acids 150-174 of PP32 are responsible for its tumor suppressor function and are a region of divergence with PP32R1.  Alternative use of PP32, PP32R1, and PP32R2 may modulate the oncogenic potential of human prostate cancer.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                       
[20830] "Encoded by human ANP32D Gene, 131-amino acid 14.8 kD PP32R2 Protein (PP32 Family) shares approximately 90% amino acid sequence identity with tumor suppressor PP32 and PP32R1.  PP32 can inhibit several types of cancers, including prostate and breast cancers.  PP32R2 and PP32R1 are tumorigenic.  Amino acids 150-174 of PP32 are responsible for its tumor suppressor function and are a region of divergence with PP32R1. Alternative use of PP32, PP32R1, and PP32R2 may modulate the oncogenic potential of human prostate cancer.  PP32R2 is expressed in prostate cancer. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                              
[20831] "Encoded by human APPBP2 Gene, ubiquitous 70 kD cytoplasmic Amyloid Beta Precursor Protein-Binding Protein 2 contains terminal globular structures, a coiled coil domain, PKC phosphorylation sites, and four imperfect C-terminal tandem repeats.  In the Golgi apparatus, APPBP2 is associated with transport or processing of amyloid precursor protein (APP).  Cell surface sorting of the signal-transducing APP depends on a cytoplasmic tyrosine-based basolateral sorting signal (BaSS) sequence to which APPBP2 specifically binds.  Amyloid BaSS tyrosine mutation prevents APPBP2 binding and results in nonpolarized transport.  Similar to the kinesin light chain, APPBP2 also interacts with microtubules and may have a role in vesicle sorting.  APPBP2 is abundantly expressed in breast cancer.  (from OMIM, and NCI)"                                                                                                                                                            
[20832] "Encoded by human ARHI Gene, the 229-amino acid 26 kD RHO-Related GTP-Binding Protein RHOI (RHO Family) appears to be a tumor suppressor expressed in breast and ovarian epithelial cells, and in heart, liver, pancreas, and brain; expression is absent in breast and ovarian cancer cell lines.  Growth factors decrease expression of RHOI Protein, as does WAF1 (CDKN1A).  The 229 amino acid protein shares 54% amino acid homology with HRAS and 56-62% homology with RAS-related proteins, and contains a highly conserved GTP-binding domain, a putative effector domain distinct from RAS and RAP proteins, and a C-terminal membrane localization motif.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                               
[20833] "Axin 2 protein is presumed to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. The deregulation of beta-catenin is an apparent important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. (from Locus Link)"                                                                                                                                                                                                                                                                                                        
[20834] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20835] "Encoded by the ubiquitously expressed human BAP1 Gene. The 729-amino acid nuclear BRCA1 Associated Protein-1 contains an acidic region, a highly charged C- terminus, and putative nuclear localization signals.  The N-terminus shows homology to ubiquitin C-terminal hydrolases, thiol proteases that catalyze ubiquitin proteolytic processing. BAP1 interacts with the BRCA1 RING finger, but this interaction is prevented by RING finger germline mutations of BRCA1 found in breast cancer kindreds. BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth, acting as a tumor suppressor in the BRCA1 growth control pathway.  (from OMIM)"                                                                                                                                                                                                                                                                                                                                  
[20836] "Encoded by human BCAR1 Gene, conserved ubiquitous 870-amino acid 116 kD cytoplasmic p130CAS (CAS Family) is an adaptor molecule: Ser-region, NH-SH3, central YXXP motif SH2-binding site substrate domain, SRC SH3-binding site COOH Pro-rich binding region, and C-terminal HLH. SH3 localizes CAS to focal adhesions; interacts with FAK1 P-rich region. FAK1 phosphorylates CAS YDYVHL motif. SRCs phosphorylate CAS. CAS SH2-binding sites may bind CRK, NCK, and ABL. CAS HLH may dimerize CASL. CAS Ser region promotes serum response. CAS moves to focal adhesions upon integrin triggered Y-phosphorylation. CAS complexes with CRKL and LYN. CAS functions in cardiovascular development, actin assembly, cell migration, and growth. Over expression confers breast cancer anti-estrogen resistance.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                  
[20837] "The mitotic/spindle checkpoint ensures that all replicated chromatids are properly connected to opposing spindle poles before separation (anaphase) can begin. The proteins responsible for this form a complex on the kinetochores."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20838] "Encoded by human BCAR2 Gene, Breast Cancer Anti-Estrogen Resistance 2 Protein is similar to gamma-butyrobetaine 2-oxoglutarate dioxygenase (C. elegans, Drosophila) and likely responsible for development of an anti-estrogen-resistant phenotype.  (from Int J Cancer. 1997; 72:700, LocusLink, GeneCard, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20839] "The human BUB1 gene at chromosome 2q14 encodes a 120-kD serine/threonine protein kinase, BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog (Yeast). This protein monitors the attachment of chromosomes to spindle poles and may be a component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. As part of a common complex in checkpoint-activated cells, Bub1 monitors different spindle events compared to BubR1 and integrates different signals into a single signal that is then relayed to the downstream cell cycle machinery. It interacts with Bub3, CENP-F, CENP-E and mitosin. The BUB1 gene is highly expressed in thymus followed by spleen. Defects in Bub1 are associated with tumor formation. (From LocusLink, Swiss_Prot and NCI)"                                                                                                                                                                         
[20840] "BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog (Yeast), encoded by the human BUB1 gene, is a 120-kD serine/threonine protein kinase. This protein monitors the attachment of chromosomes to spindle poles and may be a component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. As part of a common complex in checkpoint-activated cells, Bub1 monitors different spindle events compared to BubR1 and integrates different signals into a single signal that is then relayed to the downstream cell cycle machinery. It interacts with Bub3, CENP-F, CENP-E and mitosin. The BUB1 gene is highly expressed in thymus followed by spleen. Defects in Bub1 are associated with tumor formation. (From LocusLink, Swiss_Prot and NCI)"                                                                                                                                                                                     
[20841] "Encoded by human BCAR3 Gene, the 92.6 kD 825-amino acid BCAR3 Protein contains a putative SH2 domain, a hallmark of tyrosine kinase signaling molecules, and sequences homologous to CDC48 (Yeast).  Abundant expression is seen in heart, placenta, skeletal muscle, spleen, prostate, testis, ovary, small intestine, colon, fetal kidney, and several cancer cell lines, but not in nonmalignant breast tissue.  NSP2 induces anti-estrogen resistance in estrogen-dependent breast tumors.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20842] "Encoded by human BCAS1 Gene, the predicted 584-amino acid 62 kD NABC1 Protein has no significant homology to other proteins and has unknown function.  It is over expressed in most but not all breast cancer cell lines in which the gene is amplified and is associated with more aggressive tumor phenotypes.  Although not consistently expressed in breast cancer cell lines, NABC1 is a candidate oncogene product.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20843] "Encoded by human BCAS2 Gene, the ubiquitous 225-amino acid DAM1 Protein contains a central putative N-glycosylation site and multiple N-terminal putative phosphorylation sites.  A sequence identical to DAM1 is seen in Putative Spliceosome-Associated Protein SPF27.  (from OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20844] "Encoded by human BCAS3 Gene, 913-amino acid 99.6 kD BCAS3 Protein has an unknown function.  (from SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20845] "Encoded by human BCAS4 Gene, 211-amino acid 22.8 kD BCAS4 Protein has an unknown function but high similarity to a region of MAP4K1 and similarity to metalloendopeptidase (Drosophila).  BCAS4 is expressed in brain, heart, liver, pancreas, prostate, kidney, and lung.  (from SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20846] "Encoded by human BCDS1 Gene, BCDS1 Protein has an unknown function and is associated with breast cancer.  (from LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20847] "Encoded by human BCPR Gene, BCPR Protein appears to be associated with expression of p53, perhaps regulating its expression.  Lesions of BCPR seem to be involved in most breast cancers.  (from OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20848] "Encoded by human BC-2 Gene, 222-amino acid 32 kD BC-2 Protein has an unknown function and low similarity to Vps24p (S. cerevisiae).  (from SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20849] "Encoded by human BRCA3 Gene, BRCA3 Protein has an unknown function and is associated with breast cancer.  (from LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20850] "Encoded by human Breast Cancer Antigen NY-BR-1 Gene expressed in breast and testis, the 1341-amino acid 152 kD NY-BR-1 Protein contains an apparent DNA-binding bZIP motif and five tandem ankyrin repeats, implying a transcription factor involved in protein-protein interactions.  (from Cancer Res 2001; 61:2055, SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20851] "Encoded by human BRMS1 Gene, the widely expressed 28 kD BRMS1 Protein (BRMS1 Family) contains 246 predicted amino acids.  BRMS1 may mediate metastasis suppression in breast carcinoma; locally invasive tumors that express BRMS1 are significantly less metastatic to lungs and regional lymph nodes.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20852] "Encoded by human COX7A2L Gene, the ubiquitous 114-amino acid 12.6 kD (precursor) COX7A-Related Protein (COXVIIA Family) is homologous to mouse Sig81 and contains C-terminal residues similar to polypeptides 1 and 2 of cytochrome c oxidase subunit VIIa.  COX7A-Related Protein may be a regulatory subunit of mitochondrial COX and mediate higher energy production in estrogen target cells.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20853] "Expressed in spleen, prostate, testis, ovary, small intestine and colon by human DLC1 Gene, cytoplasmic 1091-aa 123-kD RHO-GTPase-Activating Protein 7 is a RHO-specific GTPase-activating protein and activator of PLCD1 that contains a Rho-Gap domain, a Sam domain, and a Start domain and may induce morphological changes and detachment through cytoskeletal reorganization. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20854] "Identified as a novel Fms-interacting protein. Overexpression in a bipotential myeloid progenitor cell line prevented M-CSF induced macrophage differentiation. Instead, cells differentiated into granulocytes.  Thus, appears to have an effect on lineage commitment. (from Oncogene 1999;18:6488-95)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20855] "Encoded by human EPSTI1 Gene and expressed in prostate, kidney, and lung, EPSTI1 Protein may function in epithelial stromal interaction. EPSTI1 is similar to G-protein coupled receptor family 1 (C. elegans) and G-protein coupled receptor protein signaling pathway growth hormone-releasing hormone receptor (Drosophila).  (from GeneCard, LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20856] "Encoded by human FBXW7 Gene, alpha and beta AGO Protein (F-Box Family), 707 and 627 amino acids respectively, differ in their N-termini and contain the putative functional F box and seven WD repeats.  F-box proteins constitute one of four SCF subunits of the ubiquitin protein ligase complex, involved in phosphorylation-dependent ubiquitination.  AGO protein binds to cyclin E, and probably targets it for ubiquitin-mediated degradation.  AGO mutant cells have elevated levels of cyclin E without increased cyclin E mRNA levels.  Homologue of Cdc4 (S. cerevisiae) and Archipelago (Drosophila), human AGO also has low similarity to Met30p (S. cerevisiae).  Drosophila and human AGO are 78% identical.  AGO may represent a mutational target in ovarian cancer.  (from OMIM and NCI)"                                                                                                                                                                                        
[20857] "Expressed in testis and placenta by human GAGED3 Gene (GAGE Family, CT Family), 111-aa 12-kD XAGE3 Protein has unknown function and shares similarity with GAGE/PAGE proteins, as well as with Pyridoxal-Dependent Decarboxylase Conserved Domain (C. elegans) and Larval Locomotory Behavior Glutamate Decarboxylase (Drosophila). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20858] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20859] "Identified as a novel Fms-interacting protein. Overexpression in a bipotential myeloid progenitor cell line prevented M-CSF induced macrophage differentiation. Instead, cells differentiated into granulocytes.  Thus, appears to have an effect on lineage commitment. (from Oncogene 1999;18:6488-95)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20860] "Encoded by human GA Gene, the 602-amino acid 66 kD (precursor) Glutaminase (GA Family) has a putative N-terminal mitochondrial import presequence.  Expressed in liver, brain, and pancreas, but not in kidney, heart, skeletal muscle, lung, or placenta, GA protein shares 94% and 72% sequence identity with rat liver and kidney glutaminases, respectively.  Containing two ankyrin repeats, human glutaminase is most similar to rat liver-type glutaminase, but is not liver specific.  Involved in regulation of glutamine catabolism, mitochondrial glutaminase converts L-glutamine to L-glutamate and NH3.  Glutaminase expression and activity depend on the cell proliferation state with highest levels at the beginning of the exponential growth phase. (NCI)"                                                                                                                                                                                                                      
[20861] "Encoded by human CLCA2 Gene (similar to CLCA1), the 943-amino acid Calcium-Activated Chloride Channel-2 (CLCA Family) is expressed in trachea, lung, and mammary gland and displays outward rectifying anion conductance. Family members differ in tissue distribution. CLCA2 protein contains a large N-terminal extracellular domain containing conserved cysteines, five transmembrane domains, a monobasic proteolytic cleavage consensus site, potential glycosylation sites, and potential PKC phosphorylation sites. Nascent CLCA2 may be cleaved into 86 kD N-terminal, and 34 kD C-terminal, polypeptides associated with the cell surface. CLCA2 may play a role in the pathogenesis of cystic fibrosis and in cancer metastasis to the lung, mediating vascular arrest and colonization. CLCA2 has been implicated as a tumor suppressor for breast cancer.  (from SWISS-PROT, OMIM, and NCI)"                                                                                           
[20862] "These genes encode more than 30 proteins of the complement system engaged in host defense. This system provides both an independent immune system capable of attacking microbes as well as other foreign material and an adjunct to the antibody system. Once activated, the complement system fires in a cascade-like fashion in which one component activates the next. Both swift and powerful, millions of complement components can deposit on an invading microbe within only a few minutes. Such a potent system requires strict regulation to avoid host injury. Membrane cofactor protein (MCP) is one critical regulator aimed at controlling inadvertent complement activation on host cells and nearly every cell examined expresses MCP on its cell membrane. (http://research.medicine.wustl.edu)"                                                                                                                                                                                    
[20863] "The complement system consists of more than 30 proteins engaged in host defense. It provides both an independent immune system capable of attacking microbes as well as other foreign material and an adjunct to the antibody system. Once activated, the complement system fires in a cascade-like fashion in which one component activates the next. Both swift and powerful, millions of complement components can deposit on an invading microbe within only a few minutes. Such a potent system requires strict regulation to avoid host injury. Membrane cofactor protein (MCP) is one critical regulator aimed at controlling inadvertent complement activation on host cells and nearly every cell examined expresses MCP on its cell membrane."                                                                                                                                                                                                                                            
[20864] "Highly expressed in secretory tissues (liver and pancreas) by human HYOU1 Gene (HSP70 Family), hypoxia-induced 999-aa (precursor) 150 kD Hypoxia Up-Regulated 1 Protein is an endoplasmic reticulum cytoprotectant in oxygen deprivation that may act as a chaperone with GRPs and participate in protein folding and secretion. ORP150 contains a C-terminal KNDEL sequence and N-terminal similarity to HSP70 ATPase domain. ORP150 suppression is associated with accelerated apoptosis. ORP150 expression in neurons suppresses caspase-3-like activity and enhances BDNF under hypoxia signaling. Elimination of the signal peptide through an alternative translation site may generate a cytosolic housekeeping protein. (NCI)"                                                                                                                                                                                                                                                              
[20865] "The C3 gene at chromosome 19p13.3-p13.2 encodes Complement Component 3, which plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacteria infection. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20866] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20867] "Any of the serum proteins that interact with antigen antibody complex to produce cytolytic, chemotaxic, anaphylactic, and other effects. (from CSP2000)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20868] "Encoded by human IL24 Gene, secreted Interleukin 24 Protein (IL10 Family) consists of 206 amino acids with a predicted size of 23.8 kD (precursor).  IL24 appears to represent a differentiation-, growth-, and apoptosis-associated protein.  It is growth inhibitory toward diverse tumor cells and may contribute to terminal cell differentiation.  The protein selectively induces p53-independent apoptosis in breast carcinoma cells and inhibits tumor growth in nude mice.  IL24 is a negative regulator of progression in human melonoma cells induced to terminally differentiate.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                    
[20869] "Encoded by human MLN51 Gene, ubiquitous cytoplasmic 76.3 kD MLN51 Protein contains 703 residues that share no significant homology with any known protein.  MLN51 is well conserved between vertebrate and invertebrate species suggesting an important function.  The N-terminal half contains putative nuclear localization signals and a coiled-coil domain that seems to promote MLN51 oligomerization.  The C-terminal half contains a SH2 and four SH3 binding motifs and may regulate nuclear localization.  The unusual combination of protein-protein interaction domains in MLN51 suggests a possible nucleo-cytoplasmic function.  Malignant breast carcinoma epithelial cells exhibit over expression of MLN51.  (from Oncogene 2002; 21:4422, SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                         
[20870] "Encoded by human NY-BR-20 Gene, NY-BR-20 Protein has an unknown function.  (from SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20871] "Complement Component 3, encoded by the C3 gene plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacteria infection. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20872] "Encoded by human NY-BR-84 Gene, the widely expressed 383-amino acid 43 kD NY-BR-84 Protein has an unknown function and sequence similarity to acyl-CoA thioesterase (C. elegans) and serologically defined breast cancer antigen 84 (Mouse).  (from SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20873] "Encoded by human OBTP Gene, 74-amino acid 8 kD Over-Expressed Breast Tumor Protein contains two LIM domains and may mediate protein-protein interactions.  (from SWISS-PROT, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20874] "Encoded by human PHEMX Gene, 320-amino acid 34.6 kD ubiquitous TSSC6 Protein (Tetraspanin Family) is an integral membrane protein of 290 amino acids that shows no similarity to any reported protein and may play a role in hematopoietic cell function.  High levels of expression are confined to hematopoietic tissues including peripheral blood leukocytes, thymus, and spleen.  Alterations in TSSC6 Protein or its gene may be associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, as well as lung, ovarian, and breast cancer.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                        
[20875] "Encoded by human RBBP1L1 Gene, 803-amino acid 91 kD RBP1-Like Protein is similar to RBP1, containing a Tudor domain and an ARID DNA binding domain.  Different protein isoforms are thought to exist, but all have not been fully determined.  Variant 2 encodes a shortened isoform 2 that lacks an internal protein fragment.  (from SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[20876] "Encoded by human Small Breast Epithelial Mucin Gene, 90-amino acid 9 kD Small Breast Epithelial Mucin is a putative low molecular weight secreted sialoglycoprotein expressed only in mammary and salivary glands.  (from Cancer Res 2002; 62:2736, SWISS-PROT, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[20877] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20878] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20879] "Encoded by human TSSC4 Gene, the 329-amino acid 34 kD TSSC4 Protein shows no close similarity to previously reported proteins and is expressed in fetal brain, lung, liver, and kidney.  Alterations in TSSC4 may be associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, as well as lung, ovarian, and breast cancer.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20880] "Encoded by human WFDC1 Gene, the 220-amino acid 24 kD (precursor) secretory Prostate Stromal Protein ps20 (WAP Family) is a growth inhibitor that contains a WAP four-disulfide core domain characteristic of protease inhibitors.  The WAP signature motif contains eight cysteines forming four disulfide bonds at the core of proteins that functions as a protease inhibitor in many family members.  Human ps20 shares approximately 86% and 88% identity with the rat and mouse secreted growth inhibitor proteins.  Loss of ps20 is associated with prostate, breast, and hepatocellular cancers and Wilms' tumor.  (from SWISS-PROT, OMIM, Proteome, and NCI)"                                                                                                                                                                                                                                                                                                                              
[20881] "Encoded by human WNT4 Gene, 351-amino acid 39 kD (precursor) WNT4 Protein (WNT Family) is a putative secreted paracrine cysteine-rich glycoprotein ligand for a seven transmembrane frizzled receptor influencing sex-determination. WNT family signaling proteins regulate cell fate and patterning during embryogenesis. WNT4 is similar to mouse and rat proteins Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt7a, and Wnt7b, which contain 83 conserved amino acid residues, including 21 cysteines. Wnt4 is detected in brain, lung, and kidney mesenchyme. Wnt4 appears to be an autoinducer of nephric mesenchyme-to-epithelial transition. WNT4 up regulates DAX1 (antagonizes SRY) controlling female development and preventing testes formation. WNT4, WNT2, and WNT7B may be associated with abnormal proliferation in breast tissue. (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                 
[20882] "Human C5 Gene encodes 1676-aa 19-kDa (precursor) Complement Component 5, a precursor protein containing 1 anaphylatoxin-like domain and 1 NTR domain and similar to C3, C4, and Alpha-2-Macroglobulin. By removal of 4 basic residues, C5 is processed to disulfide linked alpha and beta chains. C5 convertase cleaves the alpha chain, releasing C5a anaphylatoxin and generating C5b. C5 convertase activation of C5 initiates assembly of C5-C9 late complement components into a membrane attack complex; C5b-C6 complex is the assembly foundation of the lytic complex. C5a stimulates chemokinesis and chemotaxis of polymorphonuclear leukocytes to inflammation sites. C5 anaphylatoxin mediates local inflammatory processes; smooth muscle contraction, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. (NCI)"                                                                                                                        
[20883] "Encoded by human C5 Gene, Complement Component 5 is a precursor protein containing 1 anaphylatoxin-like domain and 1 NTR domain and similar to C3, C4, and Alpha-2-Macroglobulin. By removal of 4 basic residues, C5 is processed to disulfide linked alpha and beta chains. C5 convertase cleaves the alpha chain, releasing C5a anaphylatoxin and generating C5b. C5 convertase activation of C5 initiates assembly of C5-C9 late complement components into a membrane attack complex; C5b-C6 complex is the assembly foundation of the lytic complex. C5a stimulates chemokinesis and chemotaxis of polymorphonuclear leukocytes to inflammation sites. C5 anaphylatoxin mediates local inflammatory processes; smooth muscle contraction, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. (NCI)"                                                                                                                                             
[20884] "The CALM1 gene at chromosome 14q24-q31 encodes Calmodulin 1. Calmodulin 1 is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin 1 binds calcium and regulates proteins and enzymes in a calcium-dependent manner. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Ubiquitination strongly decreases its activity. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters. (From LocusLink, Swiss_Prot)"                                                                                                                                                                                                                                   
[20885] "The buildings and organizations where healthcare services are provided."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[20886] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20887] "RAD54-Like Protein (RAD54L), encoded by the RAD54L gene, belongs to the DEAD-like helicase superfamily. RAD54L plays a role in homologous recombination related repair of DNA double-strand breaks. The binding of RAD54L to double-strand DNA induces a DNA topological change, which facilitates homologous DNA paring and stimulates DNA recombination. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20888] "TERF1 (TRF1)-Interacting Nuclear Factor 2 (TINF2), encoded by the TINF2 gene, is a 50-kD telomere-associated protein. TINF2 regulates telomere length and prevents excessive telomere elongation. TINF2 binds telomeric DNA-binding-protein (TRF1) and is an essential mediator of TRF1 function. Three isoforms, 1, 2, and 3, may be produced by alternative splicing. TINF2 is detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. (From Swiss_Prot, LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20889] "Topoisomerase (DNA) II Binding Protein (TOPBP1), encoded by the TopBP1 gene, is a 173-kD binding protein that interacts with the C-terminal region of topoisomerase II beta. TOPBP1 may stimulate catalytic activity of topoisomerase II beta through transient breakages of DNA strands. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[20890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20891] "TREX1 protein is phosphorylated by Ataxia Telangiectasia and Rad3 Related Protein (ATR), regulates ATR expression, and is an essential component of the DNA damage checkpoint pathway. TREX1 and ATR are mutually dependent partners in cell cycle checkpoint signaling pathways. The downstream ORF encodes isozymes that contain 3-prime-to-5-prime exonuclease activity and the excision of nucleotides from DNA 3-prime termini are required by DNA replication, repair, and recombination. They remove mismatched, modified, fragmented, and normal nucleotides to generate the appropriate 3-prime termini for subsequent steps in the DNA metabolic pathways. (NCI)"                                                                                                                                                                                                                                                                                                                         
[20892] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20893] "Human OSM Gene (IL6/LIF/OSM Family) encodes 252-aa 28-kDa (precursor) secreted glycoprotein cytokine Oncostatin M, a growth regulator that inhibits proliferation of some cells and regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[20894] "Cytokines are a unique family of growth factors. Secreted primarily from leukocytes, cytokines stimulate both the humoral and cellular immune responses, as well as the activation of phagocytic cells. Cytokines that are secreted from lymphocytes are termed lymphokines, whereas those secreted by monocytes or macrophages are termed monokines. A large family of cytokines are produced by various cells of the body. Many of the lymphokines are also known as interleukins (ILs), since they are not only secreted by leukocytes but also able to affect the cellular responses of leukocytes. Specifically, interleukins are growth factors targeted to cells of hematopoietic origin. (http://indstate.edu/thcme/mwking/growth-factors)"                                                                                                                                                                                                                                                 
[20895] "Human FLT3LG Gene at 19q13.3 encodes 2 alternative isoforms of 26-kDa (precursor) FLT3 Ligand, a novel hematopoietic growth factor ligand for the FLT3 tyrosine kinase receptor: 235-aa type I membrane protein (isoform 1) and 178-aa homodimeric secreted (isoform 2). Synergizing with other colony stimulating factors and interleukins, FLT3LG stimulates proliferation of hematopoietic progenitor cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[20896] "Encoded as alternative isoforms by TREX2 Gene, Three Prime Repair Exonuclease 2 contains 3 conserved exonuclease motifs and catalyzes nucleoside monophosphate excision from 3-prime DNA termini and may be a subunit of DNA polymerase III. 26S Proteasome-Associated UCH Interacting Protein 1 results from use of a different open reading frame of TREX2 Gene, producing a protein structurally unrelated to the other isoforms that interacts with Ubiquitin C-Terminal Hydrolase 37, which may edit polyubiquitin chains on ubiquitinated substrates. Ubiquitin C-Terminal Hydrolases (UCH) hydrolyze C-terminal esters and amides of ubiquitin to generate free monomeric ubiquitin from ubiquitin proproteins, but do not deubiquitinate ubiquitin-protein conjugates or disassemble polyubiquitin chains. (NCI)"                                                                                                                                                                           
[20897] "The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for CD40 and TNF-mediated activation of NF-kappa B and programmed cell death. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, baculoviral IAP repeat-containing protein 1 (BIRC1/c-IAP1) and 2 (BIRC2/c-IAP2). BIRC1 has been shown to act as a ubiquitin ligase that induces the ubiquitination and degradation of this receptor, which may potentiate TNF-induced apoptosis. Knockout studies in mice suggested a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. (LocusLink)"                                                                                                                                                                                                                                                                                        
[20898] "The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. (LocusLink)"                                                                                                                                                                                                                                             
[20899] "TNFRSF6 gene product plays a central role in the physiological regulation of programmed cell death, and is implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this protein receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor also activates NF-kappa B, MAPK3/ERK1, and MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. (LocusLink)"                              
[20900] "The generation of ubiquitin from proproteins and the processing of polyubiquitin chains to release monomeric ubiquitin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20901] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20902] "The Ubiquitin C-Terminal Hydrolases (UCH) are deubiquitinating enzymes which hydrolyze carboxyl-terminal esters and amides of ubiquitin to generate free monomeric ubiquitin from ubiquitin proproteins, but not to deubiquitinate ubiquitin-protein conjugates or disassemble polyubiquitin chains. The expression of these enzymes is tissue-specific and developmentally regulated.  Members of this deubiquitinating family are also important modulators of cellular function. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[20903] "The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20904] "Alternative splicing of the TREX2 gene results in five transcript variants.  26S Proteasome-Associated UCH Interacting Protein 1 results from use of a different open reading frame, producing a protein structurally unrelated to the other isoforms of Three Prime Repair Exonuclease 2 also encoded by the same gene. This protein interacts with ubiquitin C-terminal hydrolase 37, which may edit polyubiquitin chains on ubiquitinated substrates. The physiological role of Ubiquitin C-terminal Hydrolases (UCH) is to hydrolyze C-terminal esters and amides of ubiquitin and to generate free monomeric ubiquitin from ubiquitin proproteins, but not to deubiquitinate ubiquitin-protein conjugates or disassemble polyubiquitin chains. (From PubMed and NCI)"                                                                                                                                                                                                                          
[20905] "The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracelluar death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20906] "The EPOR gene encodes Erythropoietin Receptor, which is a member of the cytokine receptor family. Upon erythropoietin binding, the erythropoietin receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[20907] "The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown.(LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20908] "DNA-Repair Protein Complementing XP-A Cells (XPA), the nuclear protein encoded by the XPA gene, has a zinc finger domain and is involved in the DNA excision repair pathway. XPA initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. XPA complements the defect in xeroderma pigmentosum (XP) group A (XP-A), an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders."                                                                                                                                                                                                                                                                                                                   
[20909] "X-Ray Repair Cross Complementing Protein 1 (XRCC1), encoded by the XRCC1 gene, functions in the repair of single-strand DNA breaks and sister chromatid exchange. With no catalytic activity, XRCC1 is required to interact with polynucleotide kinase (PNK) and poly(ADP-ribose) polymerase, linking DNA polymerase-beta and DNA ligase III (LIG3) with single-strand break repair and short-patch base excision repair, respectively, after treatment with ionizing radiation and alkylating agents. In the initial step of processing damaged DNA ends, XRCC1 stimulates the DNA kinase and DNA phosphatase activities of PNK at damaged DNA termini, thus accelerating the overall repair reaction in mammalian single-strand break repair pathway. XRCC1 is also required for full activity of LIG3 in rejoining of broken DNA strands. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity."                                    
[20910] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20911] "X-Ray Repair Cross Complementing Protein 2, encoded by the XRCC2 gene, is a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC2 is essential for the efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. XRCC2 also may have a role in meiosis. (from OMIM 600375, LocusLink 7516 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                     
[20912] "The CD209 gene encodes CD209 Antigen, which binds ICAM3 with high affinity. CD209 Antigen is a type II transmembrane protein consisting of 404 amino acids with 3 distinct domains. The 40-amino acid N-terminal cytoplasmic domain is separated by a hydrophobic stretch of 15 amino acids from a region consisting of 1 incomplete and 7 complete tandem repeats of nearly identical sequence. The extracellular C-terminal region (cys253 to ala404) shows homology to C-type lectins. Sequence analysis revealsthat CD209 antigen is identical to the HIV-1 gp120-binding protein. CD209 antigen, which is abundantly expressed by dentritic cells (DCs) both in vitro and in vivo, mediates transient adhesion with T cells. Since antibodies against CD209 antigen inhibited DC-induced proliferation of resting T cells, these findings predicted that CD209 antigen enables T-cell receptor engagement by stabilization of the DC/T-cell contact zone.(OMIM)"                               
[20913] "X-Ray Repair Cross Complementing Protein 3 (XRCC3), encoded by the XRCC3 gene, is a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC3 interacts directly with RAD51 and may cooperate with RAD51 during recombinational repair. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity and exposure to UV radiation is a major risk factor for the development of malignant melanoma. DNA damage caused by UV radiation is thought to play a major role in carcinogenesis. The association between polymorphisms in DNA repair genes and the development of malignant melanoma, a T allele at position 18067 in exon 7 of the XRCC3 gene is significantly associated with melanoma development. (from OMIM 600675, LocusLink 7517 and NCI)"                                                                                    
[20914] "X-Ray Repair Cross Complementing Protein 4, encoded by the XRCC4 gene, functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. XRCC4 functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. XRCC4 is a ubiquitously expressed protein. Alternative transcription initiation and alternative splicing generates several transcript variants and two protein isoforms. (NCI)"                                                                                                                                                                                                                                               
[20915] "Retinoic acid receptor alpha; binds retinoic acid and stimulates transcription in a ligand-dependent manner. (LOcusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[20916] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20917] "The TAP1 gene encodes Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP), which is a member of the superfamily of ATP-binding cassette (ABC) transporters. Being a member of the MDR/TAP subfamily and a subunit of the heterodimeric TAP1/TAP2 complex (TAP), this protein is involved in antigen processing. TAP transports peptides from the cytoplasm to the endoplasmic reticulum for assembly of MHC class I molecules. Loss of TAP function occurs more often in metastatic than in primary tumors. Loss of TAP1 expression may enhance tumor growth by enabling them to escape T-cell recognition during the effector phase of an antitumor immune response in immunized mice. However, it does not change the immunogenicity of tumor cells in the priming phase. Mutations in the TAP1 gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. (From LocusLink 6890, PMID 12019164 and NCI)"                                
[20918] "Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP), encoded by the TAP1 gene, is a member of the superfamily of ATP-binding cassette (ABC) transporters. Being a member of the MDR/TAP subfamily and a subunit of the heterodimeric TAP1/TAP2 complex (TAP), this protein is involved in antigen processing. TAP transports peptides from the cytoplasm to the endoplasmic reticulum for assembly of MHC class I molecules. Loss of TAP function occurs more often in metastatic than in primary tumors. Loss of TAP1 expression may enhance tumor growth by enabling them to escape T-cell recognition during the effector phase of an antitumor immune response in immunized mice. However, it does not change the immunogenicity of tumor cells in the priming phase. Mutations in the TAP1 gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. (From LocusLink 6890, PMID 12019164 and NCI)"                                  
[20919] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20920] "Intracellular or extracellular processes that control, manage, or govern adoption, production, or maintenance of sustained or transient changes in cell size.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[20921] "This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.(LocusLink)"                                                                                                                                                                                  
[20922] "The TAP2 Gene at chromosome 6p21.3 encodes Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP), which is a member of the superfamily of ATP-binding cassette (ABC) transporters. Being a member of the MDR/TAP subfamily and a subunit of the heterodimeric TAP1/TAP2 complex (TAP), this protein is involved in antigen processing. TAP transports peptides from the cytoplasm to the endoplasmic reticulum for assembly of MHC class I molecules. Loss of TAP function occurs more often in metastatic than in primary tumors. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. (From LocusLink 6891 and NCI)"                                                                                                                         
[20923] "Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP), encoded by the TAP2 gene, is a member of the superfamily of ATP-binding cassette (ABC) transporters. Being a member of the MDR/TAP subfamily and a subunit of the heterodimeric TAP1/TAP2 complex (TAP), this protein is involved in antigen processing. TAP transports peptides from the cytoplasm to the endoplasmic reticulum for assembly of MHC class I molecules. Loss of TAP function occurs more often in metastatic than in primary tumors. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. (From LocusLink 6891, PMID 11773612 and NCI)"                                                                                                                                 
[20924] "The protein encoded by this gene is a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds 1 ion of ferric iron. The function of this encoded protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. In addition to its function in iron transport, this protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter/allergins from serum. (Locuslink)"                                                                                                                                                                                                                                                                                       
[20925] "The CAMLG gene at chromosome 5q23 encodes Calcium Modulating Ligand (CAMLG), which blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. CAMLG binds and inactivates the key signaling intermediate calcineurin, downstream of the TCR and upstream of calcineurin, by causing an influx of calcium. This integral membrane protein may be a new participant in the calcium signal transduction pathway and implicates cyclophilin B in calcium signaling. CAMLG regulates calcium signaling in T lymphocytes and other cells. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                       
[20926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20927] "Calcium Modulating Ligand (CAMLG), encoded by the CAMLG gene, blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. CAML binds and inactivates the key signaling intermediate calcineurin, downstream of the TCR and upstream of calcineurin, by causing an influx of calcium. This integral membrane protein may be a new participant in the calcium signal transduction pathway and implicates cyclophilin B in calcium signaling. CAML regulates calcium signaling in T lymphocytes and other cells. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                              
[20928] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20929] "The CAV2 gene at chromosome 7q31.1 encodes Caveolin 2, a scaffolding protein and a major component of the inner surface of caveolae (small invaginations of the plasma membrane). CAV2 is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. CAV1 and CAV2 form Caveolin, a stable hetero-oligomeric complex important in the formation and maintenance of caveolae. CAV 2 may function as an accessory protein in conjunction with CAV 1. CAV2 interacts directly with G-protein alpha subunits and can functionally regulate their activity. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. (From LocusLink and NCI)"                                                                                                                                                                                          
[20930] "Caveolin 2, encoded by the CAV2 gene, is a scaffolding protein and a major component of the inner surface of caveolae (small invaginations of the plasma membrane). CAV2 is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. CAV1 and CAV2 form Caveolin, a stable hetero-oligomeric complex important in the formation and maintenance of caveolae. CAV2 may function as an accessory protein in conjunction with CAV1. CAV2 interacts directly with G-protein alpha subunits and can functionally regulate their activity. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. (From LocusLink and NCI)"                                                                                                                                                                                                          
[20931] "The type of ubiquitin modification determines the functional consequences for the modified protein. Polyubiquitination, which involves chains of usually four or more ubiquitins, typically seen on cytoplasmic proteins, serve as an efficient signal for recognition by the proteasome and subsequent protein degradation. (From PMID and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20932] "The type of ubiquitin modification determines the functional consequences for the modified protein. Monoubiquitination does not serve as a proteasome targeting signal, but plays other distinct roles. Target proteins are monoubiquitinated on one or more lysine residues, which serve as a signal for intracellular sorting as well as endocytosis of cell-surface proteins. Monoubiquitination of cell-surface receptors serves as a signal to target them to lysosome, where they are degraded by lysosomal proteases. (From PMID and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20933] "The CALB gene at chromosome 3q13.12 encodes Cass-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B (CBLB), a member protein of the CBL family of E3 ubiquitin ligases, which are critical negative regulators of tyrosine kinase signaling pathways in the immune system. Impairment of the CBLB signaling pathway may contribute to human autoimmune diseases, including type 1 diabetes. CBLB contains putative nuclear localization signal, zinc finger, leucine zipper, and proline-rich domains. It associates with three SH3 domain proteins FYN, FGR, and PLCG1. Three isoforms (a long form, truncated isoform 1, truncated isoform 2) are produced by alternative splicing. (From OMIM, PMID and NCI)"                                                                                                                                                                                                                                                                            
[20934] "Cass-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B (CBLB), encoded by the CALB gene, is a member of the CBL family of E3 ubiquitin ligases, which are critical negative regulators of tyrosine kinase signaling pathways in the immune system. Impairment of the CBLB signaling pathway may contribute to human autoimmune diseases, including type 1 diabetes. CBLB contains putative nuclear localization signal, zinc finger, leucine zipper, and proline-rich domains. It associates with three SH3 domain proteins FYN, FGR, and PLCG1. Three isoforms (a long form, truncated isoform 1, truncated isoform 2) are produced by alternative splicing. (From OMIM, PMID and NCI)"                                                                                                                                                                                                                                                                                                   
[20935] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20936] "Expressed in placenta, lung, lymphatic endothelia, lymph nodes, intestinal mucosa/submucosa, hemopoietic cells, and fetal liver, human CCBP2 Gene (GPCR1/Beta Chemokine Receptor Family) encodes Chemokine (C-C Motif) Receptor 9, a seven transmembrane G protein-coupled receptor for beta chemokines (MCP1, MIP1-alpha, RANTES, MCP3) and critical for recruitment of effector immune cells to inflammation sites. CCBP2 does not mediate intracellular calcium flux but may function in chemokine-driven recirculation of leukocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[20937] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20938] "Thiopurine S-methyltransferase catalyzes S-methylation of thiopurine drugs such as 6-mercaptopurine. (locusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20939] "The 34-kb 10-exon human TPMT Gene (TPMT Family) encodes monomeric 245-aa 28-kDa cytoplasmic Thiopurine S-Methyltransferase. TPMT catalyzes thiopurine S-methylation, an important metabolic pathway for thiopurine drugs such as 6-mercaptopurine and is inhibited by S-adenosyl-L-homocysteine. Individual tolerance, and therapeutic efficacy, of thiopurine drugs is associated with a polymorphism that controls levels of TPMT activity. TPMT activity varies among ethnic groups. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[20940] "Type B (gastrin) receptors of the cholecystokinin (CCK) family are found principally in the CNS and the gastrointestinal tract. In the CNS, they regulate anxiety, arousal, neuroleptic activity, and opiate-induced analgesia. Outside the CNS, they regulate gastric acid secretion and may play a role in gastrointestinal motility and growth of normal and neoplastic gastrointestinal tissue. The CCKBR gene at chromosome 11p15.4 encodes Cholecystokinin B Receptor (CCKBR), a G protein-coupled receptor for gastrin and cholecystokinin. It activates a second messenger system involving phosphatidylinositol turnover and intracellular calcium mobilization. CCKBR can selectively be blocked by nonpeptide benzodiazepine-based antagonists. A single amino acid, valine-319, is critical in determining the binding affinity for these nonpeptide antagonists. Variability in the aliphatic side chain of the amino acid in position 319 confers antagonist specificity. (NCI)"      
[20941] "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.(LocusLink)"                                                                                                                                                                                                                                                                                                            
[20942] "Type B (gastrin) receptors of the cholecystokinin (CCK) family are found principally in the CNS and the gastrointestinal tract. In the CNS, they regulate anxiety, arousal, neuroleptic activity, and opiate-induced analgesia. Outside the CNS, they regulate gastric acid secretion and may play a role in gastrointestinal motility and growth of normal and neoplastic gastrointestinal tissue. Cholecystokinin B Receptor (CCKBR), encoded by the CCKBR gene, is a G protein-coupled receptor for gastrin and cholecystokinin. It activates a second messenger system involving phosphatidylinositol turnover and intracellular calcium mobilization. CCKBR can selectively be blocked by nonpeptide benzodiazepine-based antagonists. A single amino acid, valine-319, is critical in determining the binding affinity for these nonpeptide antagonists. Variability in the aliphatic side chain of the amino acid in position 319 confers antagonist specificity. (NCI)"                     
[20943] "Microanatomy, a branch of anatomy, studies the structure of cells and their arrangement to constitute tissues at microscopic level.  Frequently, microanatomy was used interchangeably with histology.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[20944] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20945] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20946] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20948] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20949] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20950] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20951] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20952] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20953] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20954] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20955] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20956] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20957] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20958] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20960] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20961] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20963] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20965] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20966] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20968] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20969] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20970] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20971] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20972] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20973] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20974] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20975] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20976] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20977] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20979] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20980] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20981] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20982] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20984] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20985] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20986] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20988] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20991] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20993] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20994] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20995] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20998] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[20999] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21001] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21002] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21004] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21005] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21007] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21008] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21009] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21010] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21011] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21012] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21013] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21014] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21015] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21016] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21017] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21018] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21019] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21020] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21021] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21022] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21023] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21024] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21025] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21026] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21027] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21028] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21029] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21030] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21031] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21032] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21033] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21034] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21035] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21036] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21037] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21038] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[21472] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21473] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21474] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[21495] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21496] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[21504] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21505] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21506] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21507] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21508] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21509] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21510] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21511] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21512] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21513] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21515] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21516] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21517] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21518] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21519] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21522] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21523] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21524] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21526] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21527] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21529] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21531] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21534] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21535] "A gland in males that surrounds the neck of the BLADDER and the URETHRA. It secretes a substance that liquifies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[21536] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21537] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21538] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21539] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[21728] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[21839] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21840] "Modification of a rat by transgenic techniques."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[21841] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[21876] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21877] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21878] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21879] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21880] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[21882] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[21884] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[21886] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[21890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[21893] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[21895] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[21897] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[21900] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21901] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21902] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21903] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21906] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21907] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21910] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21911] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21912] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21913] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21914] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21915] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21916] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21917] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21918] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21919] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21920] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21922] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21923] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21924] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21927] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21928] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21929] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21932] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21933] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21934] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21935] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21936] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21937] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21938] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21939] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21940] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21941] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21942] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21943] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21944] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21945] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21946] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21948] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21949] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21950] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21951] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21952] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21953] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21954] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21955] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21956] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21957] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21958] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21960] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21961] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21963] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21965] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21966] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21968] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21969] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21970] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21971] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21972] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21973] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21974] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21975] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21976] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21977] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21979] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21980] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21981] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21982] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21984] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21985] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21986] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21988] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21991] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21993] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21994] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21995] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21998] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[21999] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22001] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22002] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22004] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22005] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22007] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22008] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22009] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22010] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22011] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22012] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22013] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22014] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22015] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22016] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22017] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22018] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22019] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22020] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22021] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22022] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22023] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22024] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22025] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22026] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22027] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22028] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22029] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22030] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22031] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22032] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22033] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22034] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22035] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22036] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22037] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22038] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22039] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22040] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22041] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22042] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22043] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[22380] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22381] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22382] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22383] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22384] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22385] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22386] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22387] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22388] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22389] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22390] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22391] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22392] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22393] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22394] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22395] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22396] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22397] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22398] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22399] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22400] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22401] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22402] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22403] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22404] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22405] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22406] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22407] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22408] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22409] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22410] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22411] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22412] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22413] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22414] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22415] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22416] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22417] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22418] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22419] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22420] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22421] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22422] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22423] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22424] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22425] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22426] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22427] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22428] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22429] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22430] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22431] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22432] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22433] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22434] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22435] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22436] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22437] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22438] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22439] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22440] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22441] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22442] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22443] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22444] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22445] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22446] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22447] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22448] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22449] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22450] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22451] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22452] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22453] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22454] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22455] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22456] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22457] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22458] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22459] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22460] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22461] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22462] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22463] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22464] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22465] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22466] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22467] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22468] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22469] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22470] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22471] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22472] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22473] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22474] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22475] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22476] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22477] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22478] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22479] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22480] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22481] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22482] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22483] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22484] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22485] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22486] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22487] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22488] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22489] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22490] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22491] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22492] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22493] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22494] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22495] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22496] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22497] "Either of the two fleshy, full-blooded margins of the mouth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[22498] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22499] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22500] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22501] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22502] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22503] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22504] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22505] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22506] "The anteriorly located rigid section of the PALATE."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22507] "The anteriorly located rigid section of the PALATE."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22508] "A movable fold suspended from the posterior border of the hard palate. The uvula hangs from the middle of the lower border."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22509] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22510] "One of two salivary glands in the neck, located in the space bound by the two bellies of the digastric muscle and the angle of the mandible. It discharges through the submandibular duct. The secretory units are predominantly serous although a few mucous alveoli, some with serous demilunes, occur. (Stedman, 25th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[22511] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22512] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22513] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22515] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22516] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22517] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22518] "site of neoplasm"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22519] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22522] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22523] "The portion of the pharynx between the inferior portion of the oropharynx and the larynx."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22524] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22526] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22527] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22529] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22531] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22534] "The superior portion of the body of the stomach above the level of the cardiac notch."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[22535] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22536] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22537] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22538] "not classifiable to C16.1 to C16.4"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22539] "not classifiable to C16.0 to C16.4"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22540] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22541] "An occasional sacculation or appendage of the ileum, derived from an unobliterated yolk stalk. (Dorland, 27th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22542] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22543] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22544] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22545] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22546] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22547] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22548] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22549] "Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[22550] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22551] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22552] "One of the paired paranasal sinuses, located in the body of the maxilla, communicating with the middle meatus of the nasal cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22553] "Numerous small thin-walled spaces or air cells in the ethmoid bone, where they form an ethmoidal labyrinth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22554] "One of the paired, but seldom symmetrical, air spaces located between the inner and outer compact layers of the frontal bone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22555] "One of the paired paranasal sinuses, located in the body of the sphenoid bone and communicating with the highest meatus of the nasal cavity on the same side."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22556] "The upper part of the larynx, including the epiglottis; the area above the vocal cords."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22557] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22558] "The nine cartilages of the larynx, including the cricoid, thyroid and epiglottic, and two each of arytenoid, corniculate and cuneiform."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22559] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22560] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22561] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22562] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22563] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22564] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22565] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22566] "excludes mandible C41.1"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22567] "The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22568] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22569] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22570] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22571] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22572] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22573] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22574] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22575] "An area occupying the most posterior aspect of the abdominal cavity. It is bounded laterally by the borders of the quadratus lumborum muscles and extends from the diaphragm to the brim of the true pelvis, where it continues as the pelvic extraperitoneal space."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[22576] "The conic organs which usually give outlet to milk from the mammary glands."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22577] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22578] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22579] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22580] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22581] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22582] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22583] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22584] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22585] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22586] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22587] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22588] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22589] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22590] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22591] "The Corpus uteri, or body of uterus, is the part of the uterus above the isthmus, comprising about two thirds of the non-pregnant organ. The endometrium, or tunica mucosa, is the mucous membrane comprising the inner layer of the uterine wall; it consists of a simple columnar epithelium and a lamina propria that contains simple tubular uterine glands. The structure, thickness, and state of the endometrium undergo marked change with the menstrual cycle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22592] "The smooth muscle coat of the uterus, which forms the main mass of the organ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22593] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22594] "The hollow muscular organ in which the impregnated ovum is developed into the child; it is about 7.5 cm in length in the nonpregnant woman, and consists of a main portion (body) with an elongated lower part (neck), at the extremity of which is the opening (os). The upper rounded portion of the uterus, opposite the os, is the fundus, at each extremity of which is the horn marking the part where the uterine tube joins the uterus and through which the ovum reaches the uterine cavity after leaving the ovary. The organ is supported in the pelvic cavity by the broad ligaments, round ligaments, cardinal ligaments, and rectouterine and vesicouterine folds or ligaments. SYN metra, womb."                                                                                                                                                                                                                                                                                     
[22595] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22596] "A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22597] "A fibromuscular band that attaches to the uterus and then passes along the broad ligament, out through the inguinal ring, and into the labium majus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[22598] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22599] "The appendages of the UTERUS: the FALLOPIAN TUBES, OVARIES, and supporting ligaments of the uterus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22600] "The excretory organ of the embryo, collective Wolffian tubules, which forms the urogenital fold from which the reproductive organs develop. The mesonephros is the permanent kidney in fish and amphibians, but atrophies in reptiles, birds, and mammals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[22601] "the primary male sex organs or genitals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22602] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22603] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22604] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22605] "A developmental defect characterized by failure of the testes to descend into the scrotum. (Dorland, 27th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22607] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22608] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22609] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22610] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22611] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22612] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22613] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22614] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22615] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22616] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22617] "The urinary canal of the fetus; postnatally it is usually a fibrous cord but occasionally persists as a vesicoumbilical fistula."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22618] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22619] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22620] "A thin, transparent mucous membrane that covers the posterior surface of lids (palpebral conjunctiva) and the outer surface of the sclera (bulbar conjunctiva)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22621] "The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous epithelium, Bowman's membrane, stroma, DESCEMET'S MEMBRANE, and mesenchymal endothelium. It serves as the first refracting medium of the eye. It is structurally continuous with the sclera, is avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the trigeminal nerve via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)"                                                                                                                                                                                                                                                                                                                                                                     
[22622] "The light-receptive, innermost, nervous tunic of the eye which represents the terminal expansion of the optic nerve. It is a thin, transparent membrane lying between the vitreous body and the choroid and extending from the optic disk to the ciliary body, where it becomes continuous with the inner epithelium of the ciliary body. Grossly, the retina is composed of an outer, pigmented layer and an inner, transparent layer which comprises nine layers. (From Cline et al., Dictionary of Visual Science, 4th ed & Dorland, 27th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22623] "The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22624] "A ring of tissue extending from the scleral spur to the ora serrata of the retina. It consists of the uveal portion and the epithelial portion. The ciliary muscle is in the uveal portion and the ciliary processes are in the epithelial portion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22625] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22626] "The bony cavity of the skull which contains the eye, anterior portion of the optic nerve, ocular muscles and ocular adnexa.  Seven bones contribute to the structure of the orbit: the frontal, maxillary, zygomatic, sphenoid, lacrimal, ethmoid, and palatine bones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22627] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22628] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22629] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22630] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22631] "The anterior part of the cerebral hemisphere."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22632] "Lower lateral part of the cerebral hemisphere."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22633] "Upper central part of the cerebral hemisphere."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22634] "Posterior part of the cerebral hemisphere."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[22635] "Four connected cavities (hollow spaces) in the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[22636] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22637] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22638] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22639] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22640] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22641] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22642] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22643] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22644] "The extraembryonic membrane which contains the EMBRYO and AMNIOTIC FLUID."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22645] "is an organ that primarily consists of bone tissue organized into compact (cortical) and cancellous bone (macroscopic organ components); together with other bones, cartilages and joints, it constitutes the skeletal system. Example(s): femur, sternum, maxilla, vertebra, talus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[22646] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22647] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22648] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22649] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22650] "The muscle tissue of the HEART composed of striated, involuntary muscle known as cardiac muscle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22651] "The vessels carrying blood away from the heart."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22652] "A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix of type II COLLAGEN and CHONDROITIN SULFATE. It is divided into three types: hyaline cartilage, fibrocartilage, and yellow or elastic white fibrocartilage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22653] "Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22654] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22655] "Any of the ducts conveying bile between the liver and the intestine, including hepatic, cystic, and common bile duct."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[22656] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22657] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22658] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22659] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22660] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22661] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22662] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22663] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22664] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22665] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22666] "excludes ileocecal valve C18.0"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22667] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22668] "The portion of the digestive canal between the pharynx and stomach. It is about 25 cm long and consists of three parts: the cervical part, from the cricoid cartilage to the thoracic inlet; thoracic part, from thoracic inlet to the diaphragm; and abdominal part, below the diaphragm to the cardiac opening of the stomach."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22669] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22670] "An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[22671] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22672] "A large, elongated, racemose gland situated transversely behind the stomach, between the spleen and the duodenum. (Dorland, 28th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[22673] "The organ of hearing: composed of the external ear, which includes the auricle and the external acoustic, or auditory, meatus; the middle ear, or the tympanic cavity with its ossicles; and the internal ear or inner ear, or labyrinth, which includes the semicircular canals, vestibule, and cochlea. SEE ALSO auricle. SYN auris."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22674] "The part of the internal ear that is concerned with hearing. It forms the anterior part of the labyrinth, is conical, and is placed almost horizontally anterior to the vestibule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22675] "The outer layer of the adrenal gland. It secretes mineralocorticoids, androgens, and glucocorticoids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[22676] "The inner part of the adrenal gland; it synthesizes, stores and releases catecholamines."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22677] "A small conical midline body attached to the posterior part of the third ventricle and lying between the superior colliculi, below the splenium of the corpus callosum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22678] "A small, unpaired gland situated in the sella turcica tissue. It is connected to the hypothalamus by a short stalk."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22679] "A highly vascular endocrine gland consisting of two lobes, one on either side of the trachea, joined by a narrow isthmus; it produces the thyroid hormones which are concerned in regulating the metabolic rate of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[22680] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22681] "the primary female sex organs or genitals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[22682] "Two long muscular tubes that transport ova from the ovaries to the uterus. They extend from the horn of the uterus to the ovaries and consist of an ampulla, an infundibulum, an isthmus, two ostia, and a pars uterina. The walls of the tubes are composed of three layers: mucosal, muscular, and serosal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22683] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22684] "The hollow muscular organ in which the impregnated ovum is developed into the child; it is about 7.5 cm in length in the nonpregnant woman, and consists of a main portion (body) with an elongated lower part (neck), at the extremity of which is the opening (os). The upper rounded portion of the uterus, opposite the os, is the fundus, at each extremity of which is the horn marking the part where the uterine tube joins the uterus and through which the ovum reaches the uterine cavity after leaving the ovary. The organ is supported in the pelvic cavity by the broad ligaments, round ligaments, cardinal ligaments, and rectouterine and vesicouterine folds or ligaments. SYN metra, womb."                                                                                                                                                                                                                                                                                     
[22685] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22686] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22687] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22688] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22689] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22690] "Either of the paired male reproductive glands that produce the male germ cells and the male hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[22691] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22692] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22693] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22694] "One of a pair of thick-walled tubes that transports urine from the KIDNEY PELVIS to the BLADDER."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22695] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22696] "For oncology, area of the body generally construed to comprise base of skull and facial bones, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature and lymph nodes draining these areas. (DCTD-CO)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22697] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22698] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22699] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22700] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22701] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22702] "The proximal portion of the respiratory passages on either side of the nasal septum, lined with ciliated mucosa, extending from the nares to the pharynx."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22703] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22704] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22705] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22706] "The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[22707] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22708] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22709] "The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22710] "An organ that produces lymphocytes, filters the blood, stores blood cells, and destroys those that are aging. It is located on the left side of the abdomen near the stomach. (OCC)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22711] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22712] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22713] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22714] "Striated muscles are appendicular and axial muscles typically connected at either or both ends to the bony skeleton of the body.  Striated muscle fibers contain a highly organized, contractile cytoskeletal apparatus with a striated microscopic appearance; muscle contraction is typically under voluntary control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22715] "Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22716] "That portion of the nervous system consisting of the brain and spinal cord. (Dorland, 28th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22717] "That part of the central nervous system contained within the cranium, comprising the prosencephalon, mesencephalon, and rhombencephalon. It is derived from the anterior part of the embryonic neural tube. Functions include muscle control and coordination, sensory reception and integration, speech production, memory storage, and the elaboration of thought and emotions. (Dorland, 28th ed) (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[22718] "Almond-shaped group of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe. The amygdala is part of the limbic system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22719] "The part of the brain that connects the cerebral hemispheres with the spinal cord. It consists of the MESENCEPHALON, PONS, and MEDULLA OBLONGATA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22720] "The lower portion of the brainstem located between the pons and brainstem.  This structure contains several descending and ascending tracts, lower cranial nerve nuclei , a significant proportion of the reticular system of the brainstem and other structures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22721] "The outer layer of the adrenal gland. It secretes mineralocorticoids, androgens, and glucocorticoids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[22722] "A curved elevation of gray matter extending the entire length of the floor of the temporal horn of the lateral ventricle (Dorland, 28th ed). The hippocampus, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22723] "Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[22724] "Broad plate of dense myelinated fibers that reciprocally interconnect regions of the cortex in all lobes with corresponding regions of the opposite hemisphere. The corpus callosum is located deep in the longitudinal fissure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22725] "Large subcortical nuclear masses derived from the telencephalon and located in the basal regions of the cerebral hemispheres."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22726] "Striped gray and white matter consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the thalamus in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The white matter is the internal capsule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22727] "The representation of the phylogenetically oldest part of the corpus striatum called the paleostriatum. It forms the smaller, more medial part of the lentiform nucleus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22728] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22729] "Elongated gray mass of the neostriatum located adjacent to the lateral ventricle of the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22730] "The largest and most lateral of the basal ganglia lying between the lateral medullary lamina of the globus pallidus and the external capsule. It is part of the neostriatum and forms part of the lentiform nucleus along with the globus pallidus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22731] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22732] "Lens-shaped structure on the inner aspect of the internal capsule. The subthalamic nucleus and pathways traversing this region are concerned with the integration of somatic motor function. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p52)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22733] "The part of the brain developed from the most rostral of the three primary vesicles of the embryonic neural tube and consisting of the DIENCEPHALON and TELENCEPHALON."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22734] "The paired caudal parts of the prosencephalon from which the THALAMUS, HYPOTHALAMUS, EPITHALAMUS, and SUBTHALAMUS are derived."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22735] "The dorsal posterior subdivision of the diencephalon. The epithalamus is generally considered to include the habenular nuclei (HABENULA) and associated fiber bundles, the PINEAL BODY, and the epithelial roof of the third ventricle. The anterior and posterior paraventricular nuclei of the thalamus are included with the THALAMIC NUCLEI although they develop from the same pronuclear mass as the epithalamic nuclei and are sometimes considered part of the epithalamus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22736] "Hypothalamus is an important supervisory center in the brain, rich in ganglia, nerve fibers, and synaptic connections. It is composed of several sections called nuclei, each of which controls a specific function. The hypothalamus regulates body temperature, blood pressure, heartbeat, metabolism of fats and carbohydrates, and sugar levels in the blood. Through direct attachment to the pituitary gland, the hypothalamus also meters secretions controlling water balance and milk production in the female. The role of the hypothalamus in awareness of pleasure and pain is well established in the laboratory. It is involved in the expression of emotions, such as fear and rage, and in sexual behaviors. Despite its numerous vital functions, the hypothalamus in humans accounts for only 1/300 of total brain weight, and is about the size of an almond. Structurally, it is joined to the thalamus; the two work together to monitor the sleep-wake cycle."                
[22737] "Paired bodies containing mostly gray substance and forming part of the lateral wall of the third ventricle of the brain. The thalamus represents the major portion of the diencephalon and is commonly divided into cellular aggregates known as nuclear groups."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22738] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22739] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22740] "Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22741] "The rod-shaped body, composed of cells derived from the mesoblast and defining the primitive axis of the embryo. In lower vertebrates, it persists throughout life as the main axial support of the body, but in higher vertebrates it is replaced by the vertebral column."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22742] "is an organ that consists of neural tissue (which is organized into gray matter and white matter) and the central canal (organ cavity); it is embryologically derived from the caudal part of the neural tube. Together with the brain, the spinal cord constitutes the central nervous system. Example(s): There is only one spinal cord; it is an instance of organ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22743] "The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22744] "is an organ that primarily consists of nerve fibers aggregated into fasciculi by connective tissue to form an elongated, cable-like organ; together with other nerves it constitutes the peripheral nervous system. Example(s): radial nerve, sciatic nerve, vagus, chorda tympani, phrenic nerve, pelvic splanchnic nerve [but not some nerve plexuses that include in their name the term \"nerve\" (e.g., carotid nerve, superior hypogastric nerve)]."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22745] "Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22746] "Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22747] "The thin serous membrane enveloping the lungs and lining the thoracic cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22748] "The natural covering of the body; the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22749] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22750] "Connective tissue composed of fat cells lodged in the meshes of areolar tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22751] "The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22752] "Immunologically important lymphocyte that is not thymus-dependent, is either short-lived and naive or long-lived and of memory phenotype, and resembles the bursa-derived lymphocyte of birds in that it is responsible for the production of immunoglobulins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22753] "cell in lowest layer of a stratified tissue, e.g., epithelium; site of tissue renewal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22754] "A thymocyte-derived lymphocyte of immunological importance that is long-lived (months to years) and is responsible for cell-mediated immunity. T lymphocyte cells form rosettes with sheep erythrocytes and, in the presence of transforming agents (mitogens), differentiate and divide. These cells have the characteristic T3 surface marker and may be further divided into subsets according to function, such as helper, cytotoxic, etc."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22755] "The largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from \"star\" cells) are irregularly shaped with many long processes, including those with \"end feet\" which form the glial (limiting) membrane and directly and indirectly contribute to the blood brain barrier. They regulate the extracellular ionic and chemical environment, and \"reactive astrocytes\" (along with microglia) respond to injury. Astrocytes have high- affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitter, but their role in signaling (as in many other functions) is not well understood."                                                                                                                                                                                                                                                                                                                  
[22756] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22757] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22758] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22759] "A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22760] "Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22761] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22762] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22763] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22764] "Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22765] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22766] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22767] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22768] "The supporting connective tissue of an organ. (see also parenchyma)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22769] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22770] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22771] "The inferior region of the skull consisting of an internal (cerebral), and an external (basilar) surface."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22772] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22773] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22774] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22775] "A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22776] "That part of the ear canal external to the ear drum"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22777] "The internal ear; the essential part of the organ of hearing. It consists of an osseous and a membranous portion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22778] "A tubular structure that runs from the middle ear to the nasopharynx and is approximately 3-4 cm length. Its lumen is roughly triangular and has average diameter of 2-3 mm. The lumen is lined by ciliated pseudostratified, columnar epithelium, which sweeps material from the middle ear to the nasopharynx.  functionally collapsed at rest, with slight negative pressure present in the middle ear. It is closed at rest and opens during swallowing, sneezing, and yawning.  It serves to ventilate pressure differences between the middle ear and nasopharynx. This tube also allows middle ear secretions to drain into the nasopharynx."                                                                                                                                                                                                                                                                                                                                                
[22779] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22780] "A thin membrane that separates the external auditory canal from the middle ear.  The movement of the tympanic membrane in response to air pressure changes in the external ear facilitates the transmission of sound energy by causing vibration of the ossicular chain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22781] "A honeycombed section of bone located near the base of the skull, protruding behind the outer ear.  It is connected to the middle ear."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22782] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22783] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22784] "is an organ, the organ parts of which primarily consist of dentine and dental enamel; together with other teeth it constitutes a subdivision of the facial skeleton. Example(s): incisor, molar."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22785] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22786] "Minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane. Cells are the fundamental, structural, and functional units of living organisms. (Dorland, 28th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22787] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22788] "The uppermost portion of the brainstem located between the pons and the diencephalon.  The midbrain contains the cerebral peduncles, oculomotor, trochlear and red nuclei, substantia nigra and various other nuclei and tracts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22789] "The middle portion of the brainstem located between the midbrain and the medulla oblongata.  The fourth ventricle lies dorsal to the pons which also contains the motor trigeminal nuclei and the abducens nuclei.  The cerebellum contributes a large number of afferent fibers to the pons."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22790] "For most authors, this is the cerebral hemispheres plus the basal ganglia, but most clincians do not include the basal ganglia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22791] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22792] "An intracranial venous sinus that lies in a midline location along the lower free border of the falx cerebri of the brain. The sinus receives blood from the great cerebral vein and joins the superior sagittal sinus posteriorly. (From Carpenter & Sutin, Human Neuroanatomy, 8th ed, pp 733 {KEV 7-26-99})"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22793] "An intracranial venous sinus that lies in a superior and midline location above the interhemispheric fissure along the superior border of the falx cerebri of the brain. The sinus receives blood from the cerebral veins and drains posteriorly into the lateral sinuses of the brain, which in turn drain into the internal jugular veins. (From Carpenter & Sutin, Human Neuroanatomy, 8th ed, pp 733 {KEV 7-26-99})"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22794] "The brain, intracranial portions of the cranial nerves, intracranial blood vessels, intracranial meninges and other surrounding and supporting structures contained with the skull cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[22795] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22796] "The undifferentiated cells formed by cleavage of the fertilized ovum. This includes cells in the cleavage, morula, and blastula stages of the embryo."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[22797] "One of the cells of the blood, a leukocyte or erythrocyte.  SYN blood corpuscle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22798] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22799] "Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing hemoglobin whose function is to transport oxygen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[22800] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22801] "Erythrocytes with protoplasmic projections giving the cell a thorny appearance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22802] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22803] "Small, abnormal spherical red blood cells with more than the normal amount of hemoglobin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22804] "Committed, erythroid stem cells derived from myeloid stem cells. The progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E). BFU-E differentiate into CFU-E on stimulation by erythropoietin, and then further differentiate into erythroblasts when stimulated by other factors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22805] "Immature, nucleated erythrocytes occupying the stage of ERYTHROPOIESIS that follows formation of ERYTHROID PROGENITOR CELLS and precedes formation of RETICULOCYTES. Popularly called normoblasts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22806] "Immature ERYTHROCYTES. In humans, these are erythroid cells that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic \"reticulum\" (not the same as the endoplasmic reticulum), hence the name reticulocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[22807] "White blood cells. These include granular leukocytes (BASOPHILS, EOSINOPHILS, and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22808] "Leukocytes with abundant granules in the cytoplasm. They are divided into three groups: NEUTROPHILS, EOSINOPHILS, and BASOPHILS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22809] "Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[22810] "Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[22811] "Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[22812] "Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[22813] "White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each); those with characteristics of neither major class are called null cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22814] "Lymphocyte-like effector cells which mediate antibody-dependent cell cytotoxicity. They kill antibody-coated target cells which they bind with their Fc receptors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22815] "A critical subpopulation of regulatory T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes, which includes both the helper-inducer (T-LYMPHOCYTES, HELPER-INDUCER) and suppressor-inducer (T-LYMPHOCYTES, SUPPRESSOR-INDUCER) T-cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22816] "Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22817] "Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22818] "Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22819] "Subpopulation of CD4+ lymphocytes which induce CD8+ suppressor T-cells (T-LYMPHOCYTES, SUPPRESSOR-EFFECTOR) to suppress antibody production by B-cells. They also stimulate other cellular immune responses."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[22820] "A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and suppressor T-lymphocytes (T-LYMPHOCYTES, SUPPRESSOR-EFFECTOR)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22821] "Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These cells are distinct from natural killer cells (KILLER CELLS, NATURAL) and from KILLER CELLS mediating antibody-dependent cell cytotoxicity."                                                                                                                                                                                                                                                                                                                                                                                                                        
[22822] "Subpopulation of CD8+ T-lymphocytes which suppress antibody production or inhibit cellular immune responses. Suppressor-effector cells execute the message received from suppressor-inducer cells (T-LYMPHOCYTES, SUPPRESSOR-INDUCER)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22823] "A class of lymphocytes characterized by the lack of surface markers specific for either T or B lymphocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22824] "Lymphocytes that show specificity for autologous tumor cells. Ex vivo isolation and culturing of TIL with interleukin-2, followed by reinfusion into the patient, is one form of adoptive immunotherapy of cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22825] "Large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22826] "Monocytes made cytotoxic by ex vivo incubation with cytokines, especially interferon-gamma. AKM cells are used for adoptive immunotherapy in cancer patients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22827] "Cells which include the MONOCYTES and the GRANULOCYTES."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22828] "Cells contained in the bone marrow including fat cells (see ADIPOCYTES), STROMAL CELLS, MEGAKARYOCYTES, and the immediate precursors of most blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22829] "Progenitor cells from which all blood cells derive."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22830] "One of the two stem cells derived from HEMATOPOIETIC STEM CELLS - the other being the lymphoid progenitor cell. Derived from these myeloid progenitor cells are the ERYTHROID PROGENITOR CELLS and the MYELOID CELLS (MONOCYTES and GRANULOCYTES)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22831] "Very large bone marrow cells which release mature blood platelets."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22832] "Cells that store epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia (PARAGANGLIA, CHROMAFFIN) of the sympathetic nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22833] "A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22834] "Fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue. Fat is usually stored in the form of TRYGLYCERIDES."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22835] "Polymorphic cells that form cartilage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22836] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22837] "Characteristic cells of granulomatous hypersensitivity. They appear as large, flattened cells with increased endoplasmic reticulum. They are believed to be activated macrophages that have differentiated as a result of prolonged antigenic stimulation. Further differentiation or fusion of epithelioid cells is thought to produce multinucleated giant cells (GIANT CELLS)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22838] "Lipid-laden macrophages originating from monocytes or from smooth muscle cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22839] "Multinucleated cells (fused macrophages), characteristic of granulomatous inflammation, which form around exogenous material in the skin. They are similar in appearance to Langhans giant cells (GIANT CELLS, LANGHANS), but foreign-body giant cells have more abundant chromatin and their nuclei are scattered in an irregular pattern in the cytoplasm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[22840] "Multinucleated cells (fused macrophages) seen in granulomatous inflammations such as tuberculosis, syphilis, sarcoidosis, and deep fungal infections. They resemble foreign-body giant cells (GIANT CELLS, FOREIGN BODY) but Langhans giant cells contain less chromatin and their nuclei are arranged peripherally in a horseshoe-shaped pattern. Langhans giant cells occur frequently in delayed hypersensitivity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[22841] "A macrophage present in connective tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[22842] "Large star-shaped or pyramidal cells with a large oval nucleus and a small prominent nucleolus. These intensely phagocytic cells line the walls of the sinusoids of the liver and form a part of the reticuloendothelial system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22843] "Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22844] "Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[22845] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22846] "Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22847] "Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22848] "A large multinuclear cell associated with the absorption and removal of bone. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in cementum resorption."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22849] "Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22850] "The connective tissue cells of the ovarian follicle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[22851] "Cells found throughout the lining of the gastrointestinal tract that contain regulatory peptide hormones and/or biogenic amines. The substances are located in secretory granules and act in an endocrine or paracrine manner. Some of these substances are also found in neurons in the gut. There are at least 15 different types of endocrine cells of the gut. Some take up amine precursors and have been called APUD CELLS. However, most endocrine cells of the gut apparently have endodermal rather than neuroectodermal origin, so the relationship with APUD cells is not clear."                                                                                                                                                                                                                                                                                                                                                                                                        
[22852] "Cells found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22853] "Group of basal granular cells of the gut whose granules stain readily with silver and chromium salts. The cells secrete serotonin, substance P, and enkephalins. There are three types: gastric (antral mucosa), duodenal, and intestinal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[22854] "Irregular-shaped argyrophilic cells which produce histamine, chromogranin A/pancreastatin, and an as yet unidentified peptide hormone. They are the predominant endocrine cell type of the oxyntic (acid-producing) mucosa of the stomach. ECL cells respond to gastrin by releasing their secretory products and this source of histamine acts as the positive paracrine stimulator of the release of hydrochloric acid from the parietal cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22855] "Endocrine cells found in the pyloric gland mucosa (antral mucosa) of the stomach and responsible for the secretion of gastrin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22856] "Cells that cover the surface of the body and line its cavities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22857] "Cylindrical epithelial cells in the innermost layer of the ENAMEL ORGAN. Their functions include contribution to the development of the dentinoenamel junction by the deposition of a layer of the matrix, thus producing the foundation for the prisms (the structural units of the DENTAL ENAMEL), and production of the matrix for the enamel prisms and interprismatic substance. (From Jablonski's Dictionary of Dentistry, 1992)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22858] "Epithelial cells that line the basal half of the gastric glands. Chief cells synthesize and secrete pepsinogen, a precursor of the enzyme pepsin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22859] "The large pigment cells of fish, amphibia, reptiles and many invertebrates which actively disperse and aggregate their pigment granules. These cells include MELANOPHORES, erythrophores, xanthophores, leucophores and iridiophores. (In algae, chromatophores refer to CHLOROPLASTS. In phototrophic bacteria chromatophores refer to membranous organelles (BACTERIAL CHROMATOPHORES.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22860] "Chromatophores (large pigment cells of fish, amphibia, reptiles and many invertebrates) which contain melanin. Short term color changes are brought about by an active redistribution of the melanophores pigment containing organelles (MELANOSOMES). Mammals do not have melanophores; however they have retained smaller pigment cells known as MELANOCYTES."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22861] "Dendritic Cells are immunocompetent cells of the lymphoid and hemopoietic systems and skin. They function morphologically and phenotypically by presenting or processing antigens, thereby stimulating cellular immunity. They represent the most potent antigen-presenting cells and, therefore, play a critical role in the primary T cell immune response."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22862] "Dendritic clear cells in the epidermis, containing distinctive granules that appear rod- or racket-shaped in section, but lacking tonofilaments, melanosomes, and desmosomes; they carry surface receptors for immunoglobulin (Fc) and complement (C3), and are believed to be antigen fixing and processing cells of monocytic origin; active participants in cutaneous delayed hypersensitivity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22863] "Terminally differentiated cells comprising the majority of the external surface of the intestinal epithelium (see INTESTINAL MUCOSA). Unlike GOBLET CELLS, they do not produce or secrete mucins, nor do they secrete cryptdins as do the PANETH CELLS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22864] "Cells of the epithelial lining that produce and secrete mucins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22865] "Cells of the membrana granulosa lining the vesicular ovarian follicle which become luteal cells after ovulation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22866] "A parenchymal liver cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22867] "Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22868] "Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22869] "Epidermal dendritic pigment cells which control long-term morphological color changes by alteration in their number or in the amount of pigment they produce and store in the pigment containing organelles called MELANOSOMES. MELANOPHORES are larger cells which do not exist in mammals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[22870] "Modified epidermal cells located in the stratum basale. They are found mostly in areas where sensory perception is acute, such as the fingertips. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber. Do not confuse with Merkel's corpuscle which is a combination of a neuron and and epidermal cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22871] "Epithelial cells found in the basal part of the intestinal glands (crypts of Lieberkuhn). Paneth cells synthesize and secrete lysozyme and cryptdins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[22872] "Cells of the gastric glands which secrete hydrochloric acid and intrinsic factor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22873] "Supporting cells found in the seminiferous tubules of the testes in mammals. They surround and nourish developing sperm cells. They secrete ANDROGEN-BINDING PROTEIN and establish the blood-testis barrier."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[22874] "Cells of the higher organisms, containing a true nucleus bounded by a nuclear membrane."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22875] "The germ cells, collectively as distinguished from the somatic cells or soma, are the reproductive cells of the body, specifically, either egg or sperm cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22876] "A female germ cell extruded from the OVARY at OVULATION."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22877] "Female germ cells in stages between the prophase of the first maturation division and the completion of the second maturation division."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22878] "The primitive differentiated female gametes which give rise to oocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22879] "The fertilized ovum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[22880] "Mature male germ cells that develop in the seminiferous tubules of the testes. Each consists of a head, a body, and a tail that provides propulsion. The head consists mainly of CHROMATIN."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22881] "The anterior, usually ovoid, nucleus-containing part of spermatozoa."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[22882] "Male germ cells derived from spermatocytes and developing into spermatozoa."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22883] "Male germ cells derived from spermatogonia and developing into spermatids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[22884] "The primitive differentiated male gametes which give rise to spermatocytes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22885] "Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22886] "Irregular microscopic structures, varying from a few to hundreds of cells, scattered throughout the pancreas and comprising its endocrine portion. There are three cell types: alpha, secreting glucagon; beta, secreting insulin; and delta (D CELLS), secreting somatostatin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22887] "Cells in the interstitial tissue of the testis that are believed to furnish the internal secretion of that gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22888] "The cells of the corpus luteum which are derived from the granulosa cells and the theca cells of the Graafian follicle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22889] "Cells of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B-lymphocytes, can be defined, based on the different classes of immunoglobulins that they synthesize."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22891] "Skeletal muscle fibers having high myofibrillar ATPase activity, high glycolytic enzyme activities, and an intermediate glycogen content which produce a fast twitch. There are two types. Fast fatigable fibers, also called white fibers, have a low myoglobin content, and a small mitochondrial content, and fatigue rapidly due to their limited glycogen content and low capacity for oxidative metabolism. Fast fatigue-resistant fibers, also called red fibers, have a large mitochondrial content and a high myoglobin content, related to their resistance to fatigue. (From Best, Physiological Basis of Medical Practice, 12th ed, p100)"                                                                                                                                                                                                                                                                                                                                              
[22892] "Skeletal muscle fibers having low myofibrillar ATPase activity, low glycogen content, and high myoglobin content, high mitochondrial oxidative enzyme activities, and an intermediate mitochondrial content which produce a slow twitch and are fatigue-resistant. (From Best, Physiological Basis of Medical Practice, 12th ed, p101)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22893] "The non-neuronal cells of the nervous system. They are divided into macroglia (ASTROCYTES, OLIGODENDROGLIA, and SCHWANN CELLS) and MICROGLIA. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the blood-brain and blood-retina barriers, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear."                                                                                                                                                                                                                                                                                         
[22894] "The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling."                                                                                                                                                                                                                                                                                                                     
[22895] "A dense intricate feltwork of interwoven fine glial processes, fibrils, synaptic terminals, axons, and dendrites interspersed among the nerve cells in the gray matter of the central nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[22896] "A class of neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal satellite cells according to their location. The most important recognized function of these cells is the formation of the insulating myelin sheaths of axons in the central nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22897] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22898] "Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22899] "Heterogeneous group of immunocompetent cells that mediates the cellular immune response by processing and presenting antigens to the T-cell receptor. Traditional antigen-presenting cells include MACROPHAGES, DENDRITIC CELLS, LANGERHANS CELLS, and B-LYMPHOCYTES. Follicular dendritic cells (DENDRITIC CELLS, FOLLICULAR) are also considered to be antigen-presenting cells by some authors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22900] "Antigen Presenting Cells (APCs) located in the follicles of secondary lymphoid organs.  These dendritic cells are unique because of their location, primarily in lymphoid follicles, and because of their function in retaining antigen molecules for extended periods of time and serving as APCs for B cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22901] "Any of the conducting cells of the nervous system. A typical neuron consists of a cell body, containing the nucleus and the surrounding cytoplasm (perikaryon); several short radiating processes (dendrites); and one long process (the axon), which terminates in twiglike branches (telodendrons) and may have branches (collaterals) projecting along its course."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[22902] "Nerve fibers which project from the central nervous system to autonomic ganglia. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the spinal cord, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in synapses or continue through the splanchnic nerves to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the brain stem and sacral spinal cord. In both divisions the principal transmitter is acetylcholine but peptide cotransmitters may also be released."                                                                                                                                                                                                                                                                                                                       
[22903] "Most generally any neurons which are not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22905] "AXONS of NEURONS encased in a lipoproteinaceous material called MYELIN. Myelinated nerve fibers conduct impulses more rapidly than unmyelinated nerve fibers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22906] "Neurons which convey sensory information centrally from the periphery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22907] "Mechanoreceptors located in the organ of Corti that are sensitive to auditory stimuli and in the vestibular apparatus that are sensitive to movement of the head. In each case the accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22908] "Bulbous cells that are medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22909] "Mechanoreceptors in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22910] "Mechanoreceptors located in the acoustic maculae and the semicircular canals that mediate the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the VESTIBULOCOCHLEAR NERVE to the brain stem."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22911] "Neurons in the olfactory epithelium with proteins (RECEPTORS, ODORANT) that bind, and thus detect, odorants. Olfactory receptor neurons are bipolar. They send to the surface of the epithelium apical dendrites with non-motile cilia from which project odorant receptor molecules. Their unmyelinated axons synapse in the olfactory bulb of the brain. Unlike other neurons, they can be generated from precursor cells in adults."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22912] "Cells specialized to detect and transduce light."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22913] "Cells in invertebrates which are specialized to detect and transduce light and darkness and relay that information centrally in the nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22914] "Cells specialized to detect and transduce light. Rods and cones are the photoreceptors in the vertebrate retina."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22915] "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22916] "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22917] "The portion of the retinal rod cell between the inner segment and the pigment epithelium layer of the retina."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22918] "Neurons in the posterior (dorsal) horn of the spinal cord whose cell bodies and processes are confined entirely to the central nervous system. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to ANTERIOR HORN CELLS or to the white matter ascending and descending longitudinal fibers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22919] "Gelatinous-appearing material in the dorsal horn of the spinal cord, consisting chiefly of Golgi type II neurons and some larger nerve cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22920] "Cells of the innermost nuclear layer of the retina, the ganglion cell layer, which project axons through the optic nerve to the brain. They are quite variable in size and in the shapes of their dendritic arbors, which are generally confined to the inner plexiform layer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22921] "Neurons which send impulses peripherally to activate muscles or secretory cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22922] "Neurons which activate muscle cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[22923] "Motor neurons in the anterior (ventral) horn of the spinal cord which project to skeletal muscles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22924] "Motor neurons which activate the contractile regions of intrafusal muscle fibers, thus adjusting the sensitivity of the muscle spindles to stretch. Gamma motor neurons may be \"static\" or \"dynamic\" according to which aspect of responsiveness (or which fiber types) they regulate. The alpha and gamma motor neurons are often activated together (alpha gamma coactivation) which allows the spindles to contribute to the control of movement trajectories despite changes in muscle length."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22926] "Nerve fibers which project from cell bodies of autonomic ganglia to synapses on target organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22927] "Nerve fibers which project from parasympathetic ganglia to synapses on target organs. Parasympathetic postganglionic fibers use acetylcholine as transmitter. They may also release peptide cotransmitters."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22928] "Nerve fibers which project from sympathetic ganglia to synapses on target organs. Sympathetic postganglionic fibers use norepinephrine as transmitter, except for those innervating eccrine sweat glands (and possibly some blood vessels) which use acetylcholine. They may also release peptide cotransmitters."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22929] "The output neurons of the cerebellar cortex."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[22930] "Projection neurons in the cerebral cortex and the hippocampus. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22931] "Spherical masses consisting of amyloid fibrils and neuronal processes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22932] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22933] "Cells derived from primitive cell types in the neural crest. During ontogeny they migrate to the foregut and specific locations of the neuroendocrine system. Properly located these cells form part of the normal hormone producing tissues of the neuroendocrine system. If misdirected these cells may become hyperplastic, adenomatous, or malignant (cf. APUDOMA)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22934] "Slender, contractile, mesenchymal-like cells found in close association with capillary walls. They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells. (From Stedman, 26th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22935] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22936] "Large cells of unknown origin, usually multinucleate, whose presence is the common histologic characteristic of HODGKIN DISEASE."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22937] "Primitive blood cells derived from embryonic mesenchyme capable of differentiating into any of the blood cell line progenitor cells (erythroblasts, young granulocytic series cells, megakaryocytes, etc.)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[22938] "Colony-forming cells which give rise to neoplasms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[22939] "That portion of the body that lies between the thorax and the pelvis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[22940] "The 6th cranial nerve. The abducens nerve originates in the abducens nucleus of the pons and sends motor fibers to the lateral rectus muscles of the eye. Damage to the nerve or its nucleus disrupts horizontal eye movement control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[22941] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22942] "The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22943] "That part of the eyeball anterior to the lens."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22944] "The main trunk of the systemic arteries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22945] "The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22946] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22947] "The smallest divisions of the arteries located between the muscular arteries and the capillaries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22948] "The enteric, parasympathetic, and sympathetic nervous systems taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the central nervous system, especially the hypothalamus and the solitary nucleus, which receive information relayed from VISCERAL AFFERENTS; these and related central and sensory structures are sometimes (but not here) considered to be part of the autonomic nervous system itself."                                                                                                                                                                                                                                                                                                                                                                                                                      
[22949] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22950] "Mucus-secreting glands situated on the posterior and lateral aspect of the vestibule of the vagina."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22951] "The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22952] "Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22953] "The gallbladder and its ducts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22954] "Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22955] "Anatomical areas of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22956] "The continuation of the axillary artery; it branches into the radial and ulnar arteries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22957] "The large network of nerve fibers which distributes the innervation of the upper extremity. The brachial plexus extends from the neck into the axilla. In humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (C5-C8 and T1), but variations are not uncommon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22958] "The larger air passages of the lungs arising from the terminal bifurcation of the trachea."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[22959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22960] "The minute vessels that connect the arterioles and venules."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22961] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22962] "Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[22963] "The eight bones of the wrist: capitate bone, hamate bone, lunate bone (SEMILUNAR BONE), pisiform bone, SCAPHOID BONE, trapezium bone, trapezoid bone and triquetral bone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22964] "The lower part of the SPINAL CORD consisting of the lumbar, sacral, and coccygeal nerve roots."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[22965] "An irregularly shaped venous space in the dura mater at either side of the sphenoid bone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22966] "The arteries supplying the cerebral cortex."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22967] "The body fluid."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[22968] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22969] "A villous structure of tangled masses of BLOOD VESSELS contained within the third, lateral, and fourth ventricles of the BRAIN. It regulates part of the production and composition of CEREBROSPINAL FLUID."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22970] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22971] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22972] "The cochlear part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The cochlear nerve fibers originate from neurons of the SPIRAL GANGLION and project peripherally to cochlear hair cells and centrally to the cochlear nuclei (COCHLEAR NUCLEUS) of the BRAIN STEM. They mediate the sense of hearing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22973] "Bile ducts are passageways that carry bile. Two major bile ducts come together into a \"trunk\"-the common bile duct which empties into the upper part of the small intestine (the part next to the stomach)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[22974] "The lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22975] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22976] "A layer of vascular connective tissue underneath the EPIDERMIS. The surface of the dermis contains sensitive papillae. Embedded in or beneath the dermis are SWEAT GLANDS, hair follicles, and SEBACEOUS GLANDS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22977] "The musculofibrous partition that separates the thoracic cavity from the abdominal cavity. Contraction of the diaphragm increases the volume of the thoracic cavity aiding inspiration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22978] "The outer of the three germ layers of the embryo."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22979] "Ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22980] "The system of glands that release their secretions (hormones) directly into the circulatory system. In addition to the ENDOCRINE GLANDS, included are the CHROMAFFIN SYSTEM and the NEUROSECRETORY SYSTEMS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[22981] "The inner of the three germ layers of the embryo."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22982] "Single layer of large flattened cells covering the surface of the cornea."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22984] "Thin leaf-shaped cartilage, covered with mucous membrane, at the root of the tongue, which folds back over the entrance to the larynx, covering it, during the act of swallowing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[22985] "One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[22986] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22987] "A gland from which secretions reach a free surface of the body by ducts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22988] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[22989] "The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and salivary glands, and convey afferent information for taste from the anterior two-thirds of the tongue and for touch from the external ear."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22990] "The main artery of the thigh, a continuation of the external iliac artery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[22991] "The vein accompanying the femoral artery in the same sheath; it is a continuation of the popliteal vein and becomes the external iliac vein."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[22992] "The longest and largest bone of the skeleton, it is situated between the hip and the knee."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[22993] "The bone of the lower leg lateral to and smaller than the tibia. In proportion to its length, it is the most slender of the long bones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[22994] "Clusters of multipolar neurons surrounded by a capsule of loosely organized CONNECTIVE TISSUE located outside the CENTRAL NERVOUS SYSTEM."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22995] "Clusters of neurons and their processes in the autonomic nervous system. In the autonomic ganglia, the preganglionic fibers from the central nervous system synapse onto the neurons whose axons are the postganglionic fibers innervating target organs. The ganglia also contain intrinsic neurons and supporting cells and preganglionic fibers passing through to other ganglia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[22996] "The sensory ganglion of the facial (7th cranial) nerve. The geniculate ganglion cells send central processes to the brain stem and peripheral processes to the taste buds in the anterior tongue, the soft palate, and the skin of the external auditory meatus and the mastoid process."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22997] "The male reproductive organs. They are divided into the external organs (penis, scrotum, and urethra) and the internal organs (testis, epididymis, ductus deferens, seminal vesicle, ejaculatory duct, prostate, and bulbourethral gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[22998] "The 9th cranial nerve. The glossopharyngeal nerve is a mixed motor and sensory nerve; it conveys somatic and autonomic efferents as well as general, special, and visceral afferents. Among the connections are motor fibers to the stylopharyngeus muscle, parasympathetic fibers to the parotid glands, general and taste afferents from the posterior third of the tongue, the nasopharynx, and the palate, and afferents from baroreceptors and chemoreceptors of the carotid sinus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[22999] "The vocal apparatus of the larynx, consisting of the true vocal cords (plica vocalis) and the opening between them (rima glottidis)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23000] "The gamete-producing glands, OVARY or TESTIS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23001] "The external junctural region between the lower part of the abdomen and the thigh."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23002] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23003] "The paired upper chambers of the heart.  The left atrium receives oxygenated blood from the pulmonary vein and pumps blood into the left ventricle.  The right atrium receives venous deoxygenated blood from the entire body via the superior and inferior vena cavae and pumps blood into the right ventricle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23004] "Flaps of tissue that prevent regurgitation of blood from the ventricles to the atria or from the pulmonary arteries or aorta to the ventricles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23005] "The lower right and left chambers of the heart. The right pumps venous blood into the lungs and the left pumps oxygenated blood into the systemic arterial circulation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23007] "The 12th cranial nerve. The hypoglossal nerve originates in the hypoglossal nucleus of the medulla and supplies motor innervation to all of the muscles of the tongue except the palatoglossus (which is supplied by the vagus). This nerve also contains proprioceptive afferents from the tongue muscles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23008] "Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23009] "A vein on either side of the body which is formed by the union of the external and internal iliac veins and passes upward to join with its fellow of the opposite side to form the inferior vena cava."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23010] "The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23011] "The section of the alimentary canal from the STOMACH to the ANUS. It includes the LARGE INTESTINE and SMALL INTESTINE."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23012] "The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23013] "Veins in the neck which drain the brain, face, and neck into the brachiocephalic or subclavian veins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23014] "The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23015] "The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23016] "Cells responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as KILLER CELLS (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23017] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23018] "A biconvex transparent structure of the eye through which light is focused on the retina.  The lens sits behind the iris and is supported by the zonule, which connects it to the ciliary body.  The lens is an avascular structure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23019] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23020] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23021] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23022] "Mast cells are connective tissue cells that contain coarse, basophilic, metachromatic granules.  They are believed to contain heparin and histamine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23023] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23024] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23025] "The middle germ layer of the embryo."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23026] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23027] "The five long bones of the METATARSUS articulating with the TARSAL BONES proximally and the TOES (phalanges) distally."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23028] "The valve between the left atrium and left ventricle of the heart."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23029] "The MUSCLES, bones (BONE AND BONES), and CARTILAGE of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23030] "The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23031] "A specialized structure that serves as an organ of the sense of smell as well as part of the respiratory system; the term includes both the external nose and the nasal cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23032] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23033] "The 3d cranial nerve. The oculomotor nerve sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye. It also sends parasympathetic efferents (via the ciliary ganglion) to the muscles controlling pupillary constriction and accommodation. The motor fibers originate in the oculomotor nuclei of the midbrain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23034] "The 1st cranial nerve. The olfactory nerve conveys the sense of smell. It is formed by the axons of OLFACTORY RECEPTOR NEURONS which project from the olfactory epithelium (in the nasal epithelium) to the OLFACTORY BULB."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23035] "The portion of the optic nerve seen in the fundus with the ophthalmoscope. It is formed by the meeting of all the retinal ganglion cell axons as they enter the optic nerve."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23036] "The 2nd cranial nerve. The optic nerve conveys visual information from the retina to the brain. The nerve carries the axons of the retinal ganglion cells which sort at the optic chiasm and continue via the optic tracts to the brain. The largest projection is to the lateral geniculate nuclei; other important targets include the superior colliculi and the suprachiasmatic nuclei. Though known as the second cranial nerve, it is considered part of the central nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23037] "Oral part of the pharynx."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23038] "Air-filled extensions of the respiratory part of the nasal cavity into the frontal, ethmoid, sphenoid, and maxillary cranial bones. They vary in size and form in different individuals and are lined by the ciliated mucous membranes of the nasal cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23039] "The craniosacral division of the autonomic nervous system. The cell bodies of the parasympathetic preganglionic fibers are in brain stem nuclei and in the sacral spinal cord. They synapse in cranial autonomic ganglia or in terminal ganglia near target organs. The parasympathetic nervous system generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23040] "Two small paired endocrine glands in the region of the thyroid gland. They secrete parathyroid hormone and are concerned with the metabolism of calcium and phosphorus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23041] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23042] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23043] "The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23044] "The lower part of the abdomen that contains the intestines (the last part of the digestive tract), the stomach, and the liver. It is bound by thin membranes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23045] "Endothelial lining of the abdominal cavity, the parietal peritoneum covering the inside of the abdominal wall and the visceral peritoneum covering the bowel, the mesentery, and certain of the organs. The portion that covers the bowel becomes the serosal layer of the bowel wall."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23046] "Lymphoid tissue on the mucosa of the small intestine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23047] "The glandular or anterior lobe of the pituitary gland which secretes several hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23048] "The neural or post-neural lobe of the pituitary gland which stores and releases vasopressin, oxytocin, and neurophysins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[23049] "The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23050] "A valve situated at the entrance to the pulmonary trunk from the right ventricle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23051] "The veins that return the oxygenated blood from the lungs to the left atrium of the heart."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23052] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23053] "A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23054] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23055] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23056] "An area occupying the most posterior aspect of the abdominal cavity. It is bounded laterally by the borders of the quadratus lumborum muscles and extends from the diaphragm to the brim of the true pelvis, where it continues as the pelvic extraperitoneal space."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23057] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23058] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23059] "The white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm. (From Cline et al., Dictionary of Visual Science, 4th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23060] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23061] "A carpal bone which is located between the scaphoid and triquelateral bones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23062] "A saclike, glandular diverticulum on each ductus deferens in male vertebrates. It is united with the excretory duct and serves for temporary storage of semen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23063] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23064] "The skeleton of the head including the bones of the face and the bones enclosing the brain."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23065] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23066] "The paired bundles of nerve fibers entering and leaving the spinal cord at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots efferent, comprising the axons of spinal motor and autonomic preganglionic neurons. There are, however, some exceptions to this afferent/efferent rule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23067] "The 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment. The spinal nerve plexuses and the spinal roots are also included."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23068] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23069] "The continuation of the axillary vein which follows the subclavian artery and then joins the internal jugular vein to form the brachiocephalic vein."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23070] "The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23071] "The seven bones which form the tarsus - namely, CALCANEUS, TALUS, cuboid, navicular, and first, second and third cuneiforms. The tarsus is a skeletal part of the foot."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23072] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23073] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23074] "The upper part of the trunk between the neck and the abdomen. It contains the chief organs of the circulatory and respiratory systems. (From Stedman, 25th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23075] "The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23076] "Collections of cells organized in a cooperative arrangement for the purpose of performing a particular function."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23077] "A round-to-oval mass of lymphoid tissue embedded in the lateral wall of the PHARYNX situated on each side of the fauces, between the anterior and posterior pillars of the soft palate (PALATE, SOFT)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23078] "A porelike structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates to the canal of Schlemm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23079] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23080] "The valve consisting of three cusps situated between the right atrium and right ventricle of the heart."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23081] "The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the trigeminal ganglion and project to the trigeminal nucleus of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication."                                                                                                                                                                                                                                                                                                                                                                                                                        
[23082] "Nuclei of the trigeminal nerve situated in the brain stem. They include the nucleus of the spinal trigeminal tract (TRIGEMINAL NUCLEUS, SPINAL), the principal sensory nucleus, the mesencephalic nucleus, and the motor nucleus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23083] "The 4th cranial nerve. The trochlear nerve carries the motor innervation of the superior oblique muscles of the eye."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23084] "One of the bones that comprise the forearm. The largest aspect articulates with the humerus at the elbow joint and the smallest portion of the ulna articulates with the carpal bones in the wrist. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23085] "All the organs involved in reproduction and the formation and release of URINE. It includes the kidneys, ureters, BLADDER, URETHRA, and the organs of reproduction - ovaries, UTERUS, FALLOPIAN TUBES, VAGINA, and CLITORIS in women and the testes, SEMINAL VESICLES, PROSTATE, seminal ducts, and PENIS in men."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23086] "The pigmented vascular coat of the eyeball, consisting of the CHOROID, CILIARY BODY, and IRIS, which are continuous with each other. (Cline et al., Dictionary of Visual Science, 4th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23087] "The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23088] "Duct carrying spermatozoa."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23089] "The vessels carrying blood toward the heart."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23090] "The venous trunk which receives blood from the lower extremities and from the pelvic and abdominal organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23091] "The venous trunk which returns blood from the head, neck, upper extremities and chest."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23092] "The inferior and superior venae cavae."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23093] "The minute vessels that collect blood from the capillary plexuses and join together to form veins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23094] "The first branch of the subclavian artery with distribution to muscles of the neck, vertebrae, spinal cord, cerebellum and interior of the cerebrum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23095] "The vestibular part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The vestibular nerve fibers arise from neurons of Scarpa's ganglion and project peripherally to vestibular hair cells and centrally to the VESTIBULAR NUCLEI of the BRAIN STEM. These fibers mediate the sense of balance and head position."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23096] "The four cellular masses in the floor of the fourth ventricle giving rise to a widely dispersed special sensory system. Included is the superior, medial, inferior, and LATERAL VESTIBULAR NUCLEUS. (From Dorland, 27th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23097] "The folds of mucous membrane along either wall of the larynx from the angle between the laminae of the thyroid cartilage to the vocal process of the arytenoid cartilage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23098] "An annular transitional zone, approximately 1 mm wide, between the cornea and the bulbar conjunctiva and sclera. It is highly vascular and is involved in the metabolism of the cornea. It is ophthalmologically significant in that it appears on the outer surface of the eyeball as a slight furrow, marking the line between the clear cornea and the sclera. (Dictionary of Visual Science, 3d ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23099] "The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and foot. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot."                                                                                                                                                                                                                                                                                                                                       
[23100] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23101] "The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23102] "A centrally placed component of the ventricular system of the brain located in the diencephalon.  Cerebrospinal fluid from the lateral ventricles flows into the third ventricle via the foramina of Monroe and exits the third ventricle via the aqueduct of Sylvius.  The thalamus and hypothalamus border the lateral walls of the third ventricle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23103] "An irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the CEREBRAL AQUEDUCT above, and through its lateral and median apertures it communicates with the subarachnoid space."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23104] "Artery formed by the bifurcation of the internal carotid artery (CAROTID ARTERY, INTERNAL). Branches of the anterior cerebral artery supply the CAUDATE NUCLEUS, INTERNAL CAPSULE, PUTAMEN, SEPTAL NUCLEI, GYRUS CINGULI, and surfaces of the FRONTAL LOBE and PARIETAL LOBE."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23105] "The largest and most complex of the cerebral arteries. Branches of the middle cerebral artery supply the insular region, motor and premotor areas, and large regions of the association cortex."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23106] "Artery formed by the bifurcation of the BASILAR ARTERY. Branches of the posterior cerebral artery supply portions of the OCCIPITAL LOBE, PARIETAL LOBE, inferior temporal gyrus, brainstem, and CHOROID PLEXUS."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23107] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23108] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23109] "Cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the SEPTUM PELLUCIDUM, and each communicates with the THIRD VENTRICLE by the foramen of Monro, through which also the choroid plexuses (CHOROID PLEXUS) of the lateral ventricles become continuous with that of the third ventricle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23110] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23111] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23112] "The brain stem nucleus that receives the central input from the cochlear nerve. The cochlear nucleus is located lateral and dorsolateral to the inferior cerebellar peduncles and is functionally divided into dorsal and ventral parts. It is tonotopically organized, performs the first stage of central auditory processing, and projects (directly or indirectly) to higher auditory areas including the superior olivary nuclei, the medial geniculi, the inferior colliculi, and the auditory cortex."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23113] "The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23114] "The larger of the two terminal branches of the brachial artery, beginning about one centimeter distal to the bend of the elbow. Like the RADIAL ARTERY, its branches may be divided into three groups corresponding to their locations in the forearm, wrist, and hand."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23115] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23116] "Grafts used in the treatment of skin loss, usually caused by burn injuries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23117] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23118] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23119] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23120] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23121] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23122] "An epithelium in which the cells are flattened. May be simple (e.g. Endothelium) or stratified (e.g. Epidermis). (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23123] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23124] "The part of the epidermis layer of the skin containing Langerhans cells, which are dendritic, MHC class II-expressing antigen presenting cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23125] "breast. 1. The pectoral surface of the thorax. 2. The organ of milk secretion; one of two hemispheric projections of variable size situated in the subcutaneous layer over the pectoralis major muscle on either side of the chest of the mature female; it is rudimentary in the male."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23126] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23127] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23128] "The bone which is located most lateral in the proximal row of CARPAL BONES."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23129] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23130] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23131] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23132] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23133] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23134] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23135] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23136] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23137] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23138] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23139] "One of the squamous cells forming the lining of blood and lymph vessels and the inner layer of the endocardium. SYN endotheliocyte."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23140] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23141] "epithelia of lung alveoli. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles. (OCC)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23142] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23143] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23144] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23145] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23146] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23147] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23148] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23149] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23150] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23151] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23152] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23153] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23154] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23155] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23156] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23157] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23158] "The epithelial lining of the URINARY TRACT."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23159] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23160] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23161] "The flattened, funnel-shaped expansion connecting the URETER to the KIDNEY CALICES."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23162] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23163] "The organs involved with detecting and processing auditory information, including the pinna, external auditory canal, ear drum, middle ear, and inner ear (including the cochlear organ)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23164] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23165] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23166] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23167] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23168] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23169] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23170] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23171] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23172] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23173] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23174] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23175] "The part of the conjunctiva, a thin transparent mucous membrane, that covers the posterior surface of the eyelids."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23176] "The part of the conjunctiva, a thin transparent mucous membrane, that is loosely attached the orbital septum and covers the anterior surface of the sclera."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23177] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23178] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23179] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23180] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23181] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23182] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23183] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23184] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23185] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23186] "Human colonic adenocarcinoma cells that are able to express differentiation features characteristic of mature intestinal cells, such as enterocytes or mucus cells. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23187] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23188] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23189] "A lymphoid cell of follicular center cell origin that has an irregularly shaped nucleus with clumped chromatin, absent nucleoli, and one or more clefts in the nuclear membrane."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23190] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23191] "Cells of, or derived from, a malignant tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23192] "Blast cells are in an immature (undifferentiated) stage in cellular development, occurring before the appearance of the definitive characteristics exhibited by fully differentiated cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23193] "is an anatomical structure that consists of all members of one or more organ subclass; these members are interconnected by anatomical structures or body substances. (UWDA97)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23194] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23195] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23196] "Cells of, or derived from, a tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23197] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23198] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23199] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23200] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23201] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23202] "Stratified squamous epithelium that covers the outer surface of the CORNEA. It is smooth and contains many free nerve endings."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23203] "is a subdivision of the peripheral nervous system (organ system subdivision), which consists of subdivisions of two or more nerves, which are interconnected with one another to form an network through which nerve fibers of the constituent nerves of the plexus become regrouped; together with other nerve plexuses and nerves, it constitutes the peripheral nervous system. Example(s): brachial plexus, cardiac plexus, inferior hypogastric plexus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23204] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23205] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23206] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23207] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23208] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23209] "Embryonic stem cells are pluripotent and can give rise to all of the different types of specialized cells in the body but are incapable of forming an entire organism under any known condition."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23210] "Non-encapsulated accumulations of lymphoid tissue in the alimentary tract that form a secretory immune system containing cells committed to IgA or IgE synthesis; include tonsils, Peyer's patches, lamina propria, and appendix. (CSP98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23211] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23212] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23213] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23214] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23215] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23216] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23217] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23218] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23219] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23220] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23221] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23222] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23223] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23224] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23225] "Cells of the spleen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23226] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23227] "Fluids and secretions related to the nervous system. The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. SYN systema nervosum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23228] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23229] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23230] "The components of the eye that are also part of the nervous system, including the retina and optic nerve."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23231] "exocrine gland. a gland from which secretions reach a free surface of the body by ducts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[23232] "A cell originating from or isolated from an animal of class Mammalia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23233] "Cells found in human breast cancers or extracted from cancers as established cell lines"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23234] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23235] "Trachea -The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi. Bronchi-The larger air passages of the lungs arising from the terminal bifurcation of the trachea. (from MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23236] "A tumor progenitor cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[23237] "The epithelium which lines the intestinal tract."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23238] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23239] "Relating to the vagina, to any sheath, or other female genitalia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23240] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23241] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23242] "New blood vessels formed by solid tumors."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23243] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23244] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23245] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23246] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23247] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23248] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23249] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23250] "Cells which show sign/s, that they can become cancerous."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[23251] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23252] "Totipotent stem cells, such as the product of fertilization of an ovum and its progeny, are stem cells that have total potency to form an entire mature organism, e.g., a human being, although only if placed in a woman's uterus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23253] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23254] "Arteries which have their origins within the intracranial cavity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23255] "Transference of a tissue or organ, alive or dead, within an individual, between individuals of the same species, or between individuals of different species. (MSH98)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23256] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23257] "The bones of the upper and lower ARM. They include the CLAVICLE and SCAPULA."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23258] "nodes that lie along the course of a lymphatic vessel between a primary melanoma site and a recognized node field. (from Medscape)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23259] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23261] "A small epidermoid structure of the conjunctiva of the eye that lies near the inner canthus.  It serves as a transition zone between cutaneous and mucous membrane components."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23262] "A hybrid cell with cytoplasm (or cytoplasmic components) of one cell inserted into another cell."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23263] "A thin fibrous membrane that covers the outer surface of the anteriors sclera and contains blood vessels which supply the sclera."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23264] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23265] "An embryonic nerve cell capable of differentiating into a neuron."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23266] "Splenic pulp seen grossly as a reddish brown substance, due to its abundance of red blood cells, consisting of splenic sinuses and the tissue intervening between them (splenic cords)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23267] "The part of the spleen that consists of nodules and other lymphatic concentrations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23268] "A cell that develops in the thymus, seemingly from a stem cell of bone marrow and of fetal liver, and is the precursor of the thymus-derived lymphocyte (T lymphocyte) that effects cell-mediated (delayed type) sensitivity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23269] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23270] "The eighth cranial nerve composed of the acoustic nerve and the vestibular nerve.  The nerve travels from the inner ear, enters the cranial cavity through the internal auditory foramen and joins the brainstem.  The auditory nerve conveys impulses from the cochlea of the inner ear to the auditory nuclei of the brainstem.  The vestibular nerve carries information from the labyrinths of the inner ear to the vestibular nuclei of the brainstem."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23271] "is a three-dimensional anatomical spatial entity, which is generated by morphogenetic or other physiologic processes that generate anatomical structures; it is enclosed by anatomical structures and contains one or more anatomical structures or body substances. Example(s): celom, thoracic cavity, lesser sac of peritoneum, cavity of right atrium, lumen of blood vessel, mediastinum, anterior compartment of forearm, intervertebral foramen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23272] "The spinal or vertebral column."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23273] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23274] "Large single cells, either cylindrical or prismatic in shape, that form the basic unit of muscle tissue. They consist of a soft contractile substance enclosed in a tubular sheath."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23276] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23277] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23278] "The innermost layer of the heart, comprised of endothelial cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23279] "The fibroserous sac surrounding the heart and the roots of the great vessels."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23280] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23281] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23282] "Cytolytic lymphocytes with the unique capacity of killing natural killer (NK)-resistant fresh tumor cells. They are interleukin-2-activated NK cells that have no MHC (major histocompatibility complex) restriction or need for antigen stimulation. LAK cells are used for adoptive immunotherapy in cancer patients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23283] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23284] "Small, flat, granular glands embedded in the submucous areolar tissue of the duodenum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23285] "The hepatopancreatic ampulla. A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23286] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23287] "Blast cells are in an immature (undifferentiated) stage in cellular development, occurring before the appearance of the definitive characteristics exhibited by fully differentiated cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23288] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23289] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23290] "is an organ that constitutes an anatomical junction; it consists of two or more adjacent bones, parts of which are interconnected by organ parts that consist of various types of connective tissue. Together with other joints and bones, a joint constitutes the skeletal system. Example(s): pubic symphysis, knee joint, temporomandibular joint."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23291] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23292] "Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23293] "The canals through which the testicular spermatozoa are conveyed to the rete testis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23294] "The functional units of the kidney, consisting of the glomerulus and the attached tubule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23295] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23296] "Striated muscles having fibers connected at either or both extremities with the bony framework of the body. These are found in appendicular and axial muscles. (From Stedman, 25th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23297] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23298] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23299] "Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components from interstitium to lumen; this function has been most intensively studied in the blood capillaries."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23300] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23301] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23302] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23303] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23304] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23305] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23306] "Clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons. Sensory ganglia may also have intrinsic interneurons and non-neuronal supporting cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23307] "The cells of the body which stain with chromium salts. They occur along the sympathetic nerves, in the adrenal gland, and in various other organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23308] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23309] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23310] "encompasses the mouth, esophagus, stomach, intestines, biliary tract, pancreas, liver, and associated hormones and secretions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23311] "The sphincter of the hepatopancreatic ampulla within the duodenal papilla. The COMMON BILE DUCT and main pancreatic duct pass through this sphincter."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23312] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23313] "Gray matter located in the dorsomedial part of the medulla oblongata associated with the solitary tract. The solitary nucleus receives inputs from most organ systems including the terminations of the facial, glossopharyngeal, and vagus nerves. It is a major coordinator of autonomic nervous system regulation of cardiovascular, respiratory, gustatory, gastrointestinal, and chemoreceptive aspects of homeostasis. The solitary nucleus is also notable for the large number of neurotransmitters which are found therein."                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23314] "The TARSUS, METATARSUS, and phalanges. The tarsus consists of seven bones: calcaneum, astragalus, cuboid, navicular, internal, middle, and external cuneiform bones. The five METATARSAL BONES are numbered one through five, running medial to lateral. There are 14 phalanges in each foot, the great toe has two while the other toes have three each."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23315] "The mouth, teeth, jaws, pharynx, and related structures as they relate to mastication, deglutition, and speech."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23316] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23317] "The anterior portion of the head that includes the skin, muscles, and structures of the forehead, eyes, nose, mouth, cheeks, and jaw."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23318] "The kind, number, and arrangement of teeth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23319] "Muscles of facial expression or mimetic muscles that include the numerous muscles supplied by the facial nerve that are attached to and move the skin of the face. (From Stedman, 25th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23320] "Muscles arising in the zygomatic arch that close the jaw. Their nerve supply is masseteric from the mandibular division of the trigeminal nerve. (From Stedman, 25th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[23321] "The muscles of the pharynx are the inferior, middle and superior constrictors, salpingopharyngeus, and stylopharyngeus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23322] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23323] "any of the cells lining an acinus; acinus is a general term used to designate a small saclike dilatation, particularly one found in various glands."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23324] "A thin membrane that lines the ventricles of the brain and the central canal of the SPINAL CORD."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23325] "Neural tracts connecting one part of the nervous system with another."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23326] "Nerve structures through which impulses are conducted from a peripheral part toward a nerve center."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23327] "Nerve structures through which impulses are conducted from a nerve center toward a peripheral site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23328] "White matter pathway, flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the cerebral cortex and the brainstem. It consists of three distinct parts: an anterior limb, posterior limb, and genu."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23329] "A complex group of fibers arising from the basal olfactory regions, the periamygdaloid region, and the septal nuclei, and passing to the lateral hypothalamus. Some fibers continue into the tegmentum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23330] "A pathway of fibers originating in the lateral part of the entorhinal area, perforating the subiculum of the hippocampus, and running into the stratum moleculare of the hippocampus, where these fibers synapse with others that go to the dentate gyrus. It is also called the perforating fasciculus. (Dorland, 28th ed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23331] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23332] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23333] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23334] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23335] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23336] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23337] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23338] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23339] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23340] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23341] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23342] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23343] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23344] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23345] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23346] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23347] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23348] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23349] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23350] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23351] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23352] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23353] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23354] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23355] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23356] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23357] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23358] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23359] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23360] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23361] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23362] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23363] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23364] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23365] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23366] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23367] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23368] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23369] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23370] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23371] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23372] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23373] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23374] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23375] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23376] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23377] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23378] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23379] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23380] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23381] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23382] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[23549] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23550] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23551] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23552] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23553] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23554] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23555] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23556] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23557] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23558] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23559] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23560] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23561] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23562] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23563] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23564] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23565] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23566] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23568] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23569] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23570] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23571] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23572] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23573] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23574] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23575] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23576] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23577] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23578] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23579] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23580] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23581] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23582] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23583] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23584] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23585] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23586] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23587] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23588] "Annexin V belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin V is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                             
[23589] "Human Arrestin Beta 1 Gene at 11q13 encodes Beta-Arrestin 1 (Arrestin family), which regulates Beta-Adrenergic receptor function.  Two isoforms are produced by alternative splicing.  Beta-Arrestins appear to bind phosphorylated Beta-Adrenergic receptors, impairing G(s) protein activation.  (Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23590] "Cloned by similarity to P-type ATPases, proteins that drive uphill transport of ions across membranes. Transfection of antisense constructs into a nontumorigenic cell line rendered the cells tumorigenic in nude mice. The gene is in a chromosomal region frequently deleted in human neoplasms. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23591] "This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin.  Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23592] "The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23593] "The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known."                                                                                                                                                                                                                                                                                                                                       
[23594] "The human AVPR2 locus encodes the vasopressin receptor, type 2, also known as the V2 receptor. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. AVPR2 expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. (LocusLink)"                                                                                                                                                                                                                                                                                                                                          
[23595] "The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. (LocusLink)"                                                                                                            
[23596] "The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. The function of this gene, however, is unknown. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                           
[23597] "This gene encodes Brain-specific Angiogenesis Inhibitor 1, a seven-span transmembrane protein.  BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                       
[23598] "Brain-specific angiogenesis protein BAI2 is similar to BAI1 in structure, has similar tissue specificities and may also play a role in angiogenesis. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23599] "Brain-specific angiogenesis protein BAI3 is similar to BAI1 in structure, has similar tissue specificities and may also play a role in angiogenesis. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23600] "The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. Characterized by two WW domains, a guanylate kinase domain, and five PDZ domains, this protein interacts with the cytoplasmic region of BAI1. Together, these proteins may play a role in cell adhesion and signal transduction. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23601] "The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the 3'-end of this gene results in three products of undetermined function. (LocusLink)"                                                                                                                                 
[23602] "This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. (LocusLink)"                                                                                                                                                                                      
[23603] "The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Two alternatively spliced transcript variants that encode the identical protein have been reported for this gene. (LocusLink)"                                                                                                                                                                                                                                                                                                         
[23604] "Widely expressed (3.8-kb transcript) 34-kb human BCL7A Gene at 12q24.13 encodes 231-aa 25-kD serine-rich BCL7A Protein, having 90% sequence identity (N-terminal 51-aa) with BCL7B and BCL7C; possible members of an evolutionarily conserved family. BCL7A exhibits no recognizable motifs but shows homology with actin-binding Caldesmon. BCL7A is the site of a recurrent breakpoint, with MYC and IGH, in a three-way translocation in a high-grade B cell non-Hodgkin (Burkitt) lymphoma; the N-terminal BCL7A region is disrupted. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23605] "Expressed in thymus, prostate, testis, ovary, small intestine, spleen, colon, and blood, 85-kb human BCL9 Gene at 1q21 encodes 1426-aa 150-kD nuclear B-Cell Lymphoma 9 Protein, containing an HD1 domain that interacts with the conserved PHD finger of PYGO1 and PYGO2. BCL9 (Lgs homolog, Drosophila) also binds to beta-Catenin, involved in WNT signal transduction pathway control of many fundamental developmental processes. BCL9 recruitment of PYGO to beta-Catenin may permit association with DNA-binding TCF to transcriptionally activate WNT target genes. BCL9 translocation that leaves the coding region intact is associated with B-cell acute lymphoblastic leukemia.  (NCI)"                                                                                                                                                                                                                                                                                                 
[23606] "Cloned from the region of a translocation breakpoint from a leiomyoma primary culture. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23607] "The BDKRB2 gene encodes Bradykinin Receptor B2, which is a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23608] "This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Although the gene is ubiquitously expressed, at least one isoform is concentrated in nerve terminals. Different isoforms of this protein exhibit differential binding to dynamin, synaptojanin, endophilin, and clathrin, and the protein is thought to play a role in protein targeting during synaptic vesicle endocytosis. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. (LocusLink)"                                                                                                                                                                                                                                                                                       
[23609] "This gene was identified as a gene specifically expressed in Burkitt's lymphoma and lymphatic tissues. The protein encoded by this gene is predicted to be a seven transmembrane G protein-coupled receptor and belongs to the CXC chemokine receptor family. BLC, a B-lymphocyte chemoattractant, was identified to be a specific ligand for this receptor. Studies of this gene and its mouse counterpart strongly suggest the essential function of this gene in B cell migration and localization within specific anatomic compartments, such as follicles in lymph nodes as well as in spleen. Two alternatively spliced variants of this gene exist. (LocusLink)"                                                                                                                                                                                                                                                                                                                             
[23610] "The CCM1 gene at chromosome 7q21-q22 encodes Ankyrin Repeat-Containing Protein KRIT1, which interacts with ICAP-1 and may be involved in bidirectional signaling between integrin molecules and the cytoskeleton. KRIT1 may help determine endothelial cell shape and function in response to cell-cell and cell-matrix interactions by guiding cytoskeletal structure. Defects in the CCM1 gene are responsible for the development of cerebral cavernous malformations, a relatively rare disease causing vascular malformations that may involve any part of the central nervous system. KRIT1 may affect cell adhesion processes via integrin signaling in CCM1 pathogenesis. KRIT1 also interacts with RAP1A (a member of the Ras family of GTPases) and may be involved in the RAP1A signal transduction pathway in vasculogenesis or angiogenesis. KRIT1 contains 4 ankyrin repeats, 1 band 4.1-like domain, and 1 FERM domain. (From NCI)"                                                  
[23611] "The CCNB2 gene at chromosome 15q21.2 encodes Cyclin B2, a member of the cyclin family of CDK kinase regulatory subunits, specifically the B-type cyclins. Cyclin B2 is primarily associated with the Golgi region. Cyclin B2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. Cyclin B2 interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex, activating and imparting substrate specificity to the complex. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/CDC2 may play a key role in transforming growth factor beta-mediated cell cycle control. Cyclin B2 accumulates steadily during G2 and is abruptly destroyed at mitosis. Overexpression of cyclins B, resulting from different mechanisms, could contribute, through an alteration of the spindle checkpoint, to the chromosomal instability observed in cancer. (From LocusLink, PMID and NCI)"                                  
[23612] "The CCR1 gene at 3p21 encodes Chemokine (C-C Motif) Receptor 1, a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene may have roles in host protection from inflammatory response, and susceptibility to virus and parasite. (From LocusLink and NCI)"                                                                                                                                                                                                                                      
[23613] "The CCR5 gene at 3p21 encodes Chemokine (C-C Motif) Receptor 5, a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. This receptor is expressed by T cells and macrophages, and is an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene is associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene is also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. (From LocusLink and NCI)"                                                                                 
[23614] "The CCR6 gene at 6q27 encodes Chemokine (C-C Motif) Receptor 6, a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. The CCR6 gene is preferentially expressed by immature dendritic cells and memory T cells. This receptor mediates intracellular calcium flux and binds specifically to the CC chemokine macrophage inflammatory protein 3 alpha (MIP-3 alpha). It is important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                     
[23615] "The CCR8 gene at 3p22 encodes Chemokine (C-C Motif) Receptor 8, a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. This receptor is expressed preferentially in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) are ligands of this receptor. This receptor and its ligands regulate monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                            
[23616] "Differentially expressed by T lymphocytes in small intestine and colon as well as in thymus, lymph nodes, and spleen, human CCR9 Gene (GPCR1/Beta Chemokine Receptor Family) encodes two variants of C-C Chemokine Receptor Type 9, a seven transmembrane G protein-coupled receptor and regulator of thymocyte migration/recruitment and development that may promote specialization of immune responses and inflammation in different regions of the gastrointestinal tract. CCR9 mediates intracellular calcium flux and specifically binds to CC chemokine TECK/CCL25 ligand. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                         
[23617] "The CCRL1 gene at chromosome 3q22 encodes Chemokine (C-C Motif) Receptor-Like 1, which is a G protein-coupled receptor that binds chemokines of the CC subfamily, especially MCP-4, ELC (SCYA19) and TECK (SCYA25). CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. Predominant expression of 5.0, 2.0 and 1.3kb mRNA forms exist in human heart tissue, while low-level expression of the 2.0 and 1.3kb forms in lung, pancreas and spleen and in fetal tissues. The CCRL1 gene has one intron in the 5' untranslated region. Coupled transcription-translation of CCRL1 cDNA yielded a 45kD glycosylated protein. (From LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                  
[23618] "The CCRL2 gene at 3p21 encodes Chemokine (C-C Motif) Receptor-Like 2, a seven transmembrane chemokine receptor like protein that is most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. (From LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                              
[23619] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23620] "The CD3E gene at 11q23 encodes CD3E Antigen, Epsilon Polypeptide (Tit3 Complex). The TCR/CD3 complex of T lymphocytes consists of either a TCR Alpha/Beta or TCR Gamma/Delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled Gamma, Delta, Epsilon, Zeta, and Eta. The CD3 complex mediates signal transduction and recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. The CD3E gene consists of 9 exons, three of which encode the junction of the leader peptide and the mature protein. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                
[23621] "The CD47 gene at 3q13.1-q13.2 encodes CD47 Antigen, which is a 50-kD membrane protein with an amino-terminal immunoglobulin domain and a carboxyl-terminal multiple-membrane-spanning region. CD47 Antigen is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is also involved in membrane permeability changes induced following virus infection. Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior. The interaction of CD47 with SHPS-1 may contribute to the recruitment of B lymphocytes via endothelial cells under steady state conditions. CD47 Antigen is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. Four isoforms are produced by alternative splicing. (From LocusLink, OMIM, Swiss-Prot and NCI)"                                                       
[23622] "The CD97 gene at 19p13 encodes CD97 Antigen, which is a founding member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules. CD97 Antigen is a glycoprotein present on the surface of most activated leukocytes and is a G protein-coupled receptor. This protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing generates two variants. CD97 Antigen has large N-terminal domain with five epidermal growth factor-like sequences which are differentially spliced. (From LocusLink and NCI)"         
[23623] "The CDC2L1 gene at 1p36 encodes Cell Division Cycle 2-Like 1, which is a member of the p34Cdc2 serine/threonine protein kinase family. CDC2L1 is expressed ubiquitously and acts as a negative regulator of the normal cell cycle progression. It may function in regulating proliferation by phosphorylation and subsequent plasma membrane targeting of galactosyltransferase. This gene is deleted or altered frequently in neuroblastoma with amplified MYCN genes. CDC2L1 can be cleaved by caspases and play roles in cell apoptosis. A large number of the alternatively spliced variants of this gene exist. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                          
[23624] "The CDC37 gene at 19p13.2 encodes CDC37 Homolog, a protein highly similar to Cdc 37, which is a cell division cycle control protein of Sacchromyces cerevisiae. CDC37 Homolog is a molecular chaperone with specific function in cell signal transduction. It forms complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It plays a critical role in directing the chaperone HSP90 and targeting it to the CDK4 protein kinase, thereby promoting stability of CDK4. has a role in regulating cell division cycle. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                   
[23625] "The CDC42 gene at 1p36.1 encodes Cell Division Cycle 42, a small GTPase of the Rho-subfamily. This protein regulates signaling pathways that control diverse cellular functions, including cell morphology, migration, endocytosis and cell cycle progression, and the induction of malignant trasnformation. ACK1 is a binding partner and inhibitor of the GTP-bound form of CDC42. Interaction between GTP-CDC42 and ACK1 inhibits both the intrinsic and GAP-stimulated GTPase activity of CDC42. The product of oncogene Dbl specifically catalyzes the dissociation of GDP from CDC42. This protein regulates actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of the CDC42 gene results in the placental and brain isoforms. (From LocusLink, OMIM and NCI)"                                                                                                           
[23626] "The CDK10 gene at 16q24 encodes Cyclin-Dependent Kinase 10, a protein that belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members bind to cyclin to form active holoenzymes that play a pivotal role in the regulation of the eukaryotic cell cycle and are known to be essential for cell cycle progression. This kinase has been shown to play roles in cellular proliferation and its function is limited to cell cycle G2-M phase. A variety of different transcripts exist, resulting from cryptic splice sites, exon skipping, insertion of intronic sequences, and exon scrambling. The splicing of this gene is complex. At least three alternatively spliced variants of this gene exist, one of which contains multiple non-ATG translation initiation sites. (From LocusLink, OMIM and NCI)"                                                                                                                                                       
[23627] "The CDK2 gene at 12q13 encodes Cyclin-Dependent Kinase 2, a protein that belongs to the CDKX subfamily of the Ser/Thr protein kinase family. This protein kinase is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. It is involved in promoting DNA synthesis and cell cycle progression. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene exist. Its N-terminal domain interacts with cyclins and C-terminal domain interacts with CSK1. (From LocusLink, OMIM and NCI)"                                                                                                                   
[23628] "The CDK2AP1 gene at 12q24.31 encodes CDK2-Associated Protein 1, a specific CDK2-associated protein that negatively regulates CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein also interacts with DNA polymerase alpha/primase and promotes the phosphorylation of the large p180 subunit, which suggests the regulatory role in DNA replication during S phase of the cell cycle. Reduction of CDK2AP1 protein expression is a frequent event in oral cancers and is a negative prognostic indicator in patients with surgically resected oral squamous cell carcinoma. Loss of CDK2AP1 protein expression may contribute to the multistep nature of oral carcinogenesis. (From LocusLink, PubMed and NCI)"                                                                                                                                                                                                                                          
[23629] "The CDK3 gene at 17q22-qter encodes Cyclin-Dependent Kinase 3 (CDK3), which belongs to the SER/THR family of protein kinases. CDK3 can phosphorylate histone H1 and is involved in the control of the cell cycle. CDK3 participates in the G1-S transition at least primarily by binding to E2F-1, E2F-2, or E2F-3 through DP-1 and by enhancing their transcriptional activities. CDK3 also interacts with cyclin E and cyclin A and Ik3-1/Cables is a novel substrate for CDK3-mediated phosphorylation by CDK3/cyclin E and CDK3/cyclin A. (From LocusLink, PubMed and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                     
[23630] "The CDKL2 gene at 4q21.1 encodes Cyclin-Dependent Kinase-Like 2, which is a member of a large family of CDC2-related serine/threonine protein kinases. CDKL2 is expressed as 2 major transcripts in adult testis and kidney, and at lower levels in adult brain and lung. A single transcript is detected in fetal brain and, at very low levels, in fetal kidney. This protein accumulates primarily in the cytoplasm, with a lower level in the nucleus. Treatment of cultured cells with epidermal growth factor causes an increase in the CDKL2 activity, but this does not require phosphorylation of the conserved MAP kinase dual phosphorylation motif present in this kinase. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                                              
[23631] "The CDKN2C gene at 1p32 encodes Cyclin-Dependent Kinase Inhibitor 2C, which is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with monomeric CDK4 or CDK6, and prevent the activation of the CDK kinases, thus control cell cycle G1 progression. It inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein Rb. Two alternatively spliced transcript variants of this gene encode an identical protein. This protein contains 4 ANK repeats and is found in pancreas and heart, with the highest levels in skeletal muscle. Inactivation of CDKN2C by point mutations may contribute to deregulated growth control in certain cell lines and/or tumors. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                         
[23632] "The CDKN3 gene at 14q22 encodes Cyclin-Dependent Kinase Inhibitor 3, which is a dual-specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. This protein is a cyclin-dependent kinase inhibitor and may play a role in cell cycle regulation. It has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. Delay of cell cycle progression is dependent on CDKN3 phosphatase activity. This protein also interacts with other cyclin-dependent kinases such as CDC2 and CDK3, but not with CDK4. The CDKN3 gene is deleted, mutated, or overexpressed in several kinds of cancers. Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC). (From LocusLink, Swiss-Prot, OMIM and NCI)"                                                                                                                                                                               
[23633] "The human CDON gene encodes Surface Glycoprotein, Ig Superfamily Member, which is a cell surface glycoprotein and a member of the immunoglobulin superfamily. Rhabdomyosarcoma is a childhood tumor of the skeletal muscle lineage in which cells display defects in both biochemical and morphological aspects of differentiation. The immunoglobulin superfamily members CDO and BOC are components of a cell surface receptor that positively regulates myogenesis in vitro. CDO and BOC may play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage. (From PubMed 12720294, LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                              
[23634] "The human CDR1 gene at Xq27.1-q27.2 encodes Cerebellar-Degeneration-Related Antigen 1, which is one of the target molecules recognized by autoantibodies directed against neuronal proteins in patients with paraneoplastic cerebellar degeneration, which occurs in association with small cell carcinoma of the lung, neoplasms of the breast and ovary, and Hodgkin disease. This protein contains tandem hexapeptide repeats and is expressed in brain, predominantly in normal neuroectodermal tissues and in certain malignant tumors. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                  
[23635] "The human CDX2 gene at 13q12.3 encodes Caudal Type Homeo Box Transcription Factor 2, which is a homeodomain protein. This nuclear protein is involved in the transciptional regulation of multiple genes expressed in the intestinal epithelium. It is important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Phosphorylation of Ser-60 of this protein mediates the transactivation capacity. CDX3 binds an A/T-rich sequence in the insulin promoter and stimulate its transcription. Increased CDX2 mRNA is associated with chronic atrophic gastritis and expression of CDX2 may trigger the initiation and development of intestinal metaplasia. In contrast, markedly reduced or absent CDX2 expression is noted in most large cell minimally differentiated carcinomas. (From LocusLink, Swiss-Prot, OMIM and NCI)"                                                                      
[23636] "The human CEACAM7 gene at 19q13.2 encodes Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7, which belongs to the carcinoembryonic antigen (CEA) family in the immunoglobulin superfamily. It contains one immunoglobulin-like V-type domain and one immunoglobulin-like C2-type domain. This protein is a potential tumor suppressor protein and strongly down-regulated in colon adenocarcinomas. Two isoforms (2a and 2b) of this protein are produced by alternative splicing. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23637] "The human CELSR1 gene at 22q13.3 encodes Cadherin EGF LAG Seven-Pass G-Type Receptor 1, which is a G-Protein Coupled Receptor that may have an important role in cell/cell signaling during nervous system formation. It is an integral membrane protein with seven transmembrane domains, multiple cadherin repeats, EGF-like repeats, and laminin A G-type repeats. Two isoforms (1 and 2) may be produced by alternative splicing. The CELSR1 gene is developmentally regulated and neural-specific and the protein plays an unspecified role in early embryogenesis. (From LocusLink, Swiss-Prot, PubMed and NCI)"                                                                                                                                                                                                                                                                                                                                                                              
[23638] "The human CHEK1 gene at 11q24-q24 encodes CHK1 Checkpoint Homolog, which is a serine/threonine protein kinase that is required for the DNA damage checkpoint. This protein is involved in cell cycle arrest when DNA damage has occurred or when unligated DNA is present. It binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25C on serine-216 creates a binding site for 14-3-3 protein which inhibits CDC25C. This prevents activation of the CDC2-Cyclin B complex and prevents mitotic entry. This protein is expressed ubiquitously with the most abundant expression in thymus, testis, small intestine, and colon. (From LocusLink, Swiss-Prot, PubMed and NCI)"                                                                                                                                                                                                                                                                                               
[23639] "The human CHK gene at 11q13.1 encodes Choline Kinase, which produces phosphocholine from choline. The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. Choline kinase is the initial enzyme in the sequence and may play a regulatory role. Choline kinase also catalyzes the phosphorylation of ethanolamine. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23640] "The human CHRM4 gene at 11p12-p11.2 encodes Cholinergic Receptor, Muscarinic 4, which is a G protein-coupled receptor. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and postassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. (From LocusLink and NCI)"                                                                                                                                                                                                                                                        
[23641] "The human CHS1 gene at 1q42.1-q42.2 encodes Chediak-Higashi Syndrome 1, which is Lysosomal-Trafficking Regulator Protein. This 425-kD cytoplasmic protein may sort endosomal resident proteins into late multivesicular endosome by a mechanism involving microtubules. It contains 7 WD repeats (TRP-ASP domains) and 1 beach domain, and is abundantly expressed in adult and fetal thymus, peripheral blood leukocytes, bone marrow and several regions of the adult brain. At least 3 isoforms (1, 2, 3) are produced by alternative splicing. Defects in the CHS1 gene are the cause of Chediak-Higashi Syndrome (CHS), an inherited immunodeficiency disease characterized by giant lysosomes and impaired leukocyte degranulation. (From LocusLink, Swiss-Prot, PubMed and NCI)"                                                                                                                                                                                                             
[23642] "The human CISH gene at 3p21.3 encodes Cytokine Inducible SH2-Containing Protein, which is a cytokine-inducible negative regulator of cytokine signaling. This protein contains a SH2 domain and a SOCS box domain. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein is involved in the inactivation of the erythropoietin receptor. Association with EPOR may target this protein for proteolysis by the ubiquitin-dependent proteasome pathway. The CISH protein is mainly monoubiquitinated (37 kD) but may also exist in a polyubiquitinated form (45 kD). Three isoforms (1, 1B, 1C) are produced by alternative splicing, and the tissue distribution of isoforms 1 and 1B is distinct. CISH deletion may be involved in the pathogenesis of renal cell carcinomas and of lung cancer since lung and kidney tumors frequently exhibit 3p21.3 deletions. (From LocusLink, Swiss-Prot and NCI)"    
[23643] "The human CLC gene at 11q13.3 encodes Cardiotrophin-Like Cytokine, which is a cytokine of the IL-6 family. This protein stimulates nerve cell survival and B-cell proliferation. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23644] "The human CMKLR1 gene at 12q24.1 encodes Chemokine-Like Receptor 1, which is an orphan receptor that belongs to G Protein-Coupled Receptor. This protein may be a chemotactic peptide receptor. It is expressed during bone development and may have a function in bone metabolism. It is prominently expressed in developing osseous and cartilaginous tissue. It is also found in adult parathyroid glands. It also acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Two isoforms (A, B) are produced by alternative splicing. (From Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                           
[23645] "The human CNK gene at 1p34.1 encodes Cytokine-Inducible Kinase, which is a serine/threonine protein kinase that is involved in regulating M phase functions during the cell cycle. This membrane-associated protein may play a role in regulation of cell cycle progression and tumorigenesis. It may also be part of the signaling network controlling cellular adhesion. It is phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis. Cytokine and cellular adhesion trigger CNK induction. CNK contains both a catalytic domain and a putative regulatory domain. It binds to the calcium/integrin-binding protein (CIB) and this interaction probably occurs via the polo-box domain. Transcripts expression appears to be down-regulated in primary lung tumor. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                               
[23646] "The human CNK1 gene at 1p34.1 encodes Connector Enhancer of KSR-Like (Drosophila Kinase Suppressor of Ras). Drosophila CNK is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. Drosophila CNK interacts with RAF and localizes to cell junctions, required by several pathways stimulated by receptor tyrosine kinases. The function of human CNK1 remains unknown. (From OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23647] "Encodes a novel contactin-associated transmembrane receptor (p190/Caspr) containing a mosaic of domains implicated in protein-protein interactions. The protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. (from EMBO J 1997;16:978-88)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23648] "The human COL18A1 gene at 21q22.3 encodes Collagen XVIII (Alpha 1), which is the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Three transcripts have been identified for this gene as a result of alternate promoter utilization and alternative splicing. A long variant predominates in liver, while a short variant is present in conventional basement membranes. The proteolytically produced C-terminal fragment of Collagen XVIII (Alpha 1) is endostatin, a potent antiangiogenic protein. (From LocusLink and NCI)"                                                              
[23649] "The human COL4A3 gene at 2q36-q37 encodes Collagen IV (Alpha 3), a subunit of type IV collagen, the major structural component of basement membranes. In Goodpasture syndrome, autoantibodies bind to collagen in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized to the non-collagenous C-terminal domain of this protein. There are 6 alternate transcripts unique to this gene and alternate splicing is restricted to the 6 exons encoding this domain. This protein is widely expressed. Two protein isoforms (1 and 2/Delta26/GPBPD26) are produced by alternative splicing. This gene is also linked to the autosomal recessive Alport syndrome. The mutations contributing to this syndrome are also located within the exons encoding this C-terminal region. This protein phosphorylates the Goodpasture autoantigen in vitro on Ser and Thr residues. Isoform 2 seems less active. (From LocusLink, Swiss-Prot and NCI)"    
[23650] "The human COL4A6 gene at Xq22 encodes Collagen IV (Alpha 6), a subunit of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                          
[23651] "The human COX6C gene at 8q22-q23 encodes Cytochrome C Oxidase Subunit Vic. Cytochrome C Oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The nuclear-encoded subunits may be involved in the regulation and assembly of the complex. The COX VIc subunit is found in all mammalian tissues. This mitochondrial protein does not have a presequence that targets mitochondria and the mature form itself has the property of a presequence. A pseudogene COX6CP1 has been found on chromosomes 16p12. (From LocusLink and NCI)"                                                                                                                                                                                                              
[23652] "The human CPNE7 gene at 16q24.3 encodes Copine VII, which is a calcium-dependent membrane-binding protein. Molecular events at the interface of the cell membrane and cytoplasm may be regulated by proteins that attach to and detach from the membrane surface in response to signals. Calcium-dependent membrane-binding proteins may play such a role. Copine VII contains two N-terminal C2 domains and one von Willebrand factor A domain. It may function in membrane trafficking. Two isoforms (1 and 2) may be produced by alternative splicing. This gene has been excluded as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3. (NCI)"                                                                                                                                                                                                                                                                                                                      
[23653] "The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23654] "The CSF2RB gene encodes Colony Stimulating Factor 2 Receptor, Beta, Low-Affinity (CSF2RB), which is a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defective CSF2RB has been reported to be associated with protein alveolar proteinosis. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23655] "The CSF3 gene encodes Colony Stimulating Factor 3, which is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Three transcript variants encoding three different isoforms have been found for this gene. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23656] "The CSF3 gene encodes Colony Stimulating Factor 3, which is a cytokine that controls the production, differentiation, and function of granulocytes. Colony Stimulating Factor 3, a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variants encoding four different isoforms have been found for this gene, with three of the isoforms being membrane-bound and the other being secreted and soluble. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                 
[23657] "The human CSNK1A1 gene at 5q32 encodes Casein Kinase 1, Alpha 1, which is a serine/threonine protein kinase and has broad specificity. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. This cytoplasmic protein can phosphorylate a large number of proteins. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23658] "The CSNK2A1 gene encodes Casein Kinase 2, Alpha 1 Polypeptide. Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. This kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                              
[23659] "A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23660] "Chondroitin Sulfate Proteoglycan 6 (CSPG6), encoded by the CSPG6 gene, is an abundant secreted chondroitin sulfate proteoglycan in basement membranes and an intracellular protein. CSPG6 is involved in chromosome cohesion during cell cycle and in DNA repair as a central component of the cohesin complex, which is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis and in chromosome movement. (from LocusLink)"                                                                                                                                                                                                                                           
[23661] "The CTBP2 gene produces two transcripts encoding two distinct proteins. One protein is C-Terminal Binding Protein 2, which is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23662] "Cardiotrophin 1 was cloned via its ability to potently induce cardiac myocyte hypertrophy in vitro.  It is a member of the family of cytokines that includes leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and interleukin 6 (IL6). Several members of this family that are known to signal through the transmembrane protein gp130 stimulate cardiac myocyte hypertrophy, like cardiotrophin 1, suggesting that the gp130 signaling pathway may play a role in cardiac hypertrophy. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23663] "The CTSZ Gene at 20q13 encodes Cathepsin Z, which is a lysosomal cysteine proteinase. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. At least two transcript variants of this gene have been found, but the full-length nature of only one of them has been determined. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23664] "The CUL1 gene encodes Cullin 1, an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, Cullin 1 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. It may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. (from Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23665] "Human CUL2 Gene (Cullin Family) encodes 745-aa 87-kDa Cullin 2, a component of multisubunit E3 ubiquitin ligase complexes with elongin BC complexes and other factors. Involved in the third step of ubiquitin conjugation, CUL2 may act as scaffold that positions substrate and the ubiquitin-conjugating enzyme. CUL2 interacts with RBX1, RNF7, and TIP120A/CAND1. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23666] "Widely expressed human CUL3 Gene (Cullin Family) encodes 768-aa 89-kDa neddylated nuclear and Golgi-associated Cullin 3, involved in ubiquitination of cyclin E and perhaps cyclin D1 in regulation of G1/S transition. CUL3 interacts with RBX1, RNF7, CYCE and TIP120A/CAND1. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23667] "Human CUL4a Gene (Cullin Family) encodes 659-aa 77-kDa neddylated Cullin 4, involved in the third step of ubiquitin conjugation and proteasomal degradation of target proteins. CUL4a interacts with RBX1, RNF7 and TIP120A/CAND1. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[23668] "Human CUL5 Gene (Cullin Family) encodes 780-aa 91-kDa neddylated Cullin 5, a component of E3 ubiquitin ligase complexes with elongin BC complex and diverse other factors, involved in the third step of ubiquitin conjugation and proteasomal degradation of target proteins. CUL5 interacts with RBX1 and RNF7. Evidence suggests that CUL5 may also form a cell surface vasopressin receptor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23669] "Up-regulated by chronic inflammation and expressed in brain, peripheral blood leukocytes, and spleen, the intronless 16.5-kb human CX3CR1 Gene (CCR Family, Rhodopsin Family) at 3p21.3 produces a 3.2-kb transcript that encodes a seven transmembrane high-affinity Fractalkine Receptor, a regulator of leukocyte endothelial trafficking: chemotaxis, cell migration, and adhesion. CX3CR1 signals through a pertussis toxin sensitive G-protein to induce migration and contains common GPCR features. Tyrosine sulfation enhances fractalkine-induced cell adhesion. Sharing the CX3C motif, RSV G glycoprotein can use CX3CR1 as a receptor. CX3CR1 may be an HIV envelope protein co-receptor with CD4. Homozygous CX3CR1 I249/M280 haplotype enhances infection and progression to AIDS. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                      
[23670] "Widely expressed 3.8-kb human CXCR4 Gene (GPCR1 Family) at 2q21 encodes SDF1/PBSF Receptor CXCR4 in a 1.7-kb transcript and contains two exons (0.1- and 1.6-kb) separated by a 2-kb intron between codons 5 and 6; transcript isoform 1 is predominant. The promoter likely includes a TATA box, a NRF1 site, and two GC boxes. Sulfated 352-amino acid 39.7-kD integral membrane CXCR4 Protein is a primary GPCR for CXC chemokine SDF1/PBSF that contains a 7-transmembrane region and putative glycosylation and phosphorylation sites. Responsible for B-cell lymphopoiesis, myelopoiesis, cardiogenesis, and GI vascularization, CXCR4 may regulate CNS development. It mediates leukocyte and hematopoietic cell migration and is a primary receptor for some HIV-2 viruses, as well as a CD4 co-receptor for some HIV-1 viruses by promoting env-mediated fusion. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                              
[23671] "Induced by glucocorticoids, drugs, pesticides, and carcinogens primarily in liver, the 27-kb human CYP3A4 Gene (Cytochrome P450 IIIA Subfamily) at 7q21-q22.1 is part of a cytochrome P450 gene cluster and encodes a 502-amino acid 57.3-kD membrane-bound ER heme-thiolate monooxygenase, Cytochrome P450 3A4. Activated by a range of drugs, PXR binds to CYP3A4 promoter to induce CYP3A4 expression. CAR also regulates CYP3A4 expression. HNF4A is critical in PXR and CAR transcriptional activation. CYP3A3 may be a transcript variant. CYP3A4 is involved in an NADPH-dependent electron transport pathway and phase I oxidative metabolism of carcinogens, steroids, fatty acids, and xenobiotics, as well as bioactivation of aflatoxin B(1) to a genotoxic derivative. Activity/expression seems a key predictor of drug responsiveness and toxicity. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                     
[23672] "The human tumor suppressor DAB2 Gene encodes Disabled Homolog 2 Protein, which is expressed in ovarian, breast, and lung epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, placenta, brainstem, heart, and small intestine. The 770-amino acid 82.5-kD predicted protein has 83% identity with mouse p96 protein, a putative mitogen-responsive phosphoprotein; strongest homology exists in the N-terminal PTB/PID domain. Potentially phosphorylated, DAB2 is a putative component of the CSF-1 cell proliferation signal transduction pathway. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                          
[23673] "The 4.5-kb seven-exon human DAXX Gene (DAXX Family) at 6p21.3 generates two isoforms of a ubiquitous 2.6-kb mRNA encoding a nuclear/cytoplasmic 740-amino acid 81.4-kD putative homomultimeric Death Domain-Associated Protein 6: a sumoylated, phosphorylated protein with Glu-rich, NLS, and JNK activation domains. Bound to TGFBR2 and the TNFRSF6 FAS death domain via its C-terminus, DAXX bridges apoptotic FAS activation with caspase-independent ASK1 activation of JNK. HSPB1/HSP27-DAXX may block apoptosis. As transcription co-repressor, DAXX is recruited to nucleoli or PML/POD/ND10 nuclear bodies by MCSR1 or PML. DAXX inhibits PAX3 and ETS1. As part of PAX5/CREBBP, DAXX may modulate PAX5. It binds SLC2A4/GLUT4, CENPC1, UBE2I, PAX7, DEK, HDAC1, HDAC2, HDAC3, H2A, H2B, H3, and H4. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                         
[23674] "The 203-kb human tumor suppressor DBCCR1 Gene at 9q32-q33 produces a 3.2-kb mRNA that encodes a 761-amino acid 88.9-kD DBCCR1 Protein with a MAC/Perforin domain, seven potential N-glycosylation sites, four N-myristoylation sites, and thirty phosphorylation sites. The telomeric 5-prime CpG island may be a target of hypermethylation and hypermethylation-based silencing in some bladder cancers. DBCCR1 contains eight exons expressed as a single major band of 3.0-3.5 kb in many normal tissues. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23675] "Mostly expressed in kidney proximal tubular epithelial cells, human MAP17 Gene encodes 114-aa Membrane Associated Protein 17 kDa, an intracellular protein associated with the cytoplasmic aspect of the apical brush border plasma membrane that interacts with PDZK1. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23676] "Expressed in heart, lung, brain, placenta, liver, skeletal muscle, pancreas, and kidney, the 148-kb human DDR2 Gene (InRTK Subfamily) at 1q12-q23 encodes a major 10-kb transcript that yields a 855-amino acid 96.8-kD precursor transmembrane receptor tyrosine kinase for fibrillar collagen, Discoidin Domain Receptor 2, involved in cell adhesion. Mediating fibroblast migration and proliferation, the type I membrane protein contains an intracellular catalytic domain and extracellular coagulation factor 5/8 type C and discoidin domains. RTKs often transduce signals by ligand induced receptor oligomerization, intracellular autophosphorylation, and phosphorylation of cytosolic targets. DDR2 may contribute to cutaneous wound healing. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                         
[23677] "Highly expressed in neuroectodermal tissues, the 40-kb human DDX1 Gene at 2p24 encodes a 2.4-kb mRNA that yields a 740-amino acid 82.4-kD DEAD/H Box Protein 1 of unknown function, which contains a SPRY domain and belongs to the DEAD/H box ATP-dependent RNA helicase family (member 1). DEAD box proteins, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                              
[23678] "Ubiquitously expressed 20-kb human DDX16 Gene (DEAD/H Subfamily, member 16) at 6p21.3 maps to a MHC region containing malignant, genetic, and autoimmune disease genes. A 3.4-kb mRNA encodes a 1041-amino acid 119.3-kD nuclear protein homolog of cell cycle progression protein Prp8/cdc28 (S. pombe), similar to DEAH box protein splicing factors. DEAD/H Box Protein 16 is a probable ATP-binding RNA helicase involved in pre-mRNA splicing. DEAD box proteins, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                       
[23679] "The 99-kb candidate tumor suppressor human DDX26 Gene (DEAD Family) at 13q14.12-q14.2 is located in a critical loss of heterozygosity region and encodes a highly conserved 1687-amino acid 188.5-kD DEAD/H Box Protein 26 containing a vWF type A domain with a likely important cellular function. A major 4.4-, and a minor 6.9-kb, transcript is expressed in a wide variety of fetal and adult tissues. DEAD box proteins, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                              
[23680] "The 261-kb human DEC1 Gene at 9q32 is located in a region commonly deleted in esophageal squamous cell carcinomas. A 1.4-kb transcript is widely expressed; reduced or absent in esophageal squamous cell carcinomas. DEC1 encodes a candidate tumor suppressor deduced 70-amino acid protein of unknown function; possibly negative regulation of cell proliferation. (from LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23681] "The 7.4-kb human DEFB1 Gene (Beta-Defensin Family) at 8p23.2-p23.1 includes a 7-kb intron and maps within 150-kb of the neutrophilic Alpha-Defensin-1 gene. The 362-bp mRNA encodes a 7.4-kD Beta-Defensin 1 Protein prepropeptide, containing a 68-amino acid antimicrobial peptide secreted into plasma and implicated in cystic fibrosis pathogenesis. Multiple plasma forms are bound to carrier macromolecules. Highest DEFB1 concentrations occur in kidney and female reproductive tract epithelia. Expression is not up regulated by lipopolysaccharide; IL1B appears to stimulate DEFB2 expression, but not DEFB1. DEFB1 may act in innate immunity. Mammalian alpha- and beta-defensins comprise 3.5- to 5-kD cysteine- and arginine-rich neutrophilic microbicidal and cytotoxic peptides. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                  
[23682] "The 40-kb human DEK Gene at 6p23 encodes ubiquitous 375-amino acid 43-kD nuclear RNA- and DNA-binding DEK Protein, containing a SAP domain. DEK may be involved in transcription and signal transduction. Most is associated with chromatin, a fraction with RNA. The amount and localization does not change during the cell cycle. DEK binds the HIV-2 'pets' site, interacts with histones, DAXX, and HDAC2, and induces superhelical chromatin alterations with TOP1 or TOP2A. It does not induce histone displacement, but changes nucleosomal DNA topology, and reduces replication efficiency. DEK is a spliced exon-associated spliceosome component mediated by SR protein interactions, such as SRM160. AML-associated t(6;9)(p23;q34) breakpoints in specific DEK and CAN introns fuse 5-prime DEK to 3-prime CAN with no ORF interruption. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                 
[23683] "Located between PLC-delta-1 and OSR1, human DLEC1 Gene at 3p22-p21.3 spans at least 59-kb containing 37 exons that encode numerous alternatively spliced, widely expressed 6-8-kb mRNAs (DLEC1-N, -L, -S). DLEC1-N1 and -N2 contain all 37 exons and encode a full-length 1755-amino acid 195.8-kD DLEC1 Protein, a likely negative regulator of cell proliferation. DLEC1-S1, -S2, and -S3 lack exons 11, 13, or 36 and encode frame-shifted protein. DLEC1-L1 and -L2 include all or part of intron 13 and encode prematurely truncated proteins. DLC1 expression appears to suppress growth of some cancer cell lines. Aberrant transcription may be involved in carcinogenesis of the lung, esophagus, and kidney. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                 
[23684] "The 8-kD human DLEU1 Gene at 13q14.3 lacks a TATA box, appears to have many cis-acting elements, and appears to encode a 72-amino acid putative tumor suppressor DLEU1 Protein for BCLL. Expression of a 1.1-kb transcript occurs in testis, thymus, small intestine, prostate, spleen, peripheral blood lymphocytes, and ovary. Approximately 300-bp apart, DLEU1 and DLEU2 are arranged head-to-head and transcribed in opposite directions. LEU1 is a small portion of the BCMS gene, spanning at least 560-kb and composed of 50 exons or more expressed in more than 20 tissue-specific RNA splice variants. BCMS transcripts may be noncoding RNAs.  (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                             
[23685] "The 38.6-kb human DLEU2 Gene at 13q14.3 lacks a TATA box, appears to have many cis-acting elements, and appears to encode an 84-amino acid 10-kD putative tumor suppressor DLEU2 Protein. Strong expression of 1.4- and 1.8-kb transcripts appears to occur only in thymus and testis. Approximately 300- bp apart, DLEU1 and DLEU2 are arranged head-to-head and transcribed in opposite directions. LEU2 appears to be a portion of the BCMS gene, spanning at least 560-kb and composed of 50 exons or more expressed in more than 20 tissue-specific RNA splice variants. BCMS transcripts may be noncoding RNAs.  (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                 
[23686] "Human DLG1 Gene (MAGUK Family) at 3q29 encodes alternative isoforms 1 (904-aa) and 2 (926-aa) of 100-kD Presynaptic Protein SAP97, a putative kinase that appears to regulate protein targeting and contains one SH3, one Guanylate Kinase-like, and three PDZ/DHR domains. DLG1 binds to membrane cytoskeletal protein 4.1 (EPB41) and to KIF13B, and interacts with the KCNAB1 channel as well as the cytoplasmic tail of NMDA receptor subunits. LCK interacts with the proline-rich N-terminal domain of DLG1. Interacting with actin-binding ezrin, SAP97 is also involved in cell shape morphogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                 
[23687] "Widely expressed, human DLG4 Gene (MAGUK Family) at 17p13.1 encodes 767-aa 85-kD cytoplasmic Presynaptic Density Protein 95 (concentrated at presynaptic junctions), containing one SH3, one Guanylate Kinase-like, and three PDZ/DHR domains. It heteromultimerizes with DLG2, interacts with the cytoplasmic tail of NMDA receptor subunits, and, with DLG2, mediates NMDA and potassium channel clustering. PSD-95 also binds to KIF13B and interacts through a PDZ domain with NLGN1. DLG4 may form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                                              
[23688] "The human DMBT1 gene at 10q25.3-q26.1 encodes Deleted in Malignant Brain Tumors 1, which is a member of the scavenger-receptor superfamily and likely a truncated form of a receptor for SFTPD. This 340 kD protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Binding between GP340 and SFTPD is a protein-protein interaction and the binding to GP340 takes place via the carbohydrate recognition domain of SFTPD. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. Transcript variant 2 (8.0 kb) binds surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may play a role in the interaction of tumor cells and the immune system. (From LocusLink, OMIM and NCI)"                                                        
[23689] "The human DNMT3B gene at 20q11.2 encodes DNA Methyltransferase 3B, which is required for genome wide de novo methylation and is essential for development. This nuclear protein interacts with UBL1 and UBE2I9. Six isoforms (1, 2, 3, 4, 5 and 6) are produced by alternative splicing but isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate. Defects in DNMT3B are a cause of immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. ICF is biochemically characterized by hypomethylation of CpG sites in some regions of heterochromatin. (From LocusLink, Swiss-Prot and NCI)"                                                                       
[23690] "Human DOC-1R Gene (DOC1 Family) encodes ubiquitous 126-aa 13-kDa Tumor Suppressor Deleted In Oral Cancer-Related 1 protein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23691] "The human DOCK1 gene at 10q26.13-q26.3 encodes Dedicator of Cyto-Kinesis 1, which binds to the SH3 domain of CRK protein and may be involved in integrin signaling. It may regulate cell surface extension. During programmed cell death (apoptosis), cell corpses are rapidly engulfed. This engulfment process involves the recognition and subsequent phagocytosis of cell corpses by engulfing cells. This protein may function in the cell surface extension of an engulfing cell around a dying cell during apoptosis. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23692] "The human DOK1 gene at 2p13 encodes Docking Protein 1, which interacts with receptor tyrosine kinases and mediates particular biological responses. This 62-kD protein is associated with p120 Ras-GAP and this association is correlated with its tyrosine phosphorylation. It is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. It plays an important role in mitogenic signaling and its aberrant phosphorylation may contribute to the progression of different human diseases. It is phosphorylated by the insulin receptor kinase, resulting in the negative regulation of the insulin signaling pathway. (From LocusLink, Swiss-Prot, OMIM and NCI)"                                                                                                                        
[23693] "The human DRD1 gene at 5q35.1 encodes Dopamine Receptor D1, which is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. It regulates neuronal growth and development, mediates some behavioral responses, and modulates dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23694] "The human DRD4 gene at 11p15.5 encodes Dopamine Receptor D4, which is a G-protein coupled receptor that inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. DRD4 is one of the most variable human genes known. Most of this diversity is the result of length and single-nucleotide polymorphism (SNP) variation in a 48-bp VNTR in exon 3, which encodes the third intracellular loop of this dopamine receptor. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                                         
[23695] "The human DRD5 gene at 4p16.1 encodes Dopamine Receptor D5, which is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. This receptor complexes selectively with GABA-A ligand-gated channel through the direct binding of its carboxy-terminal domain with the second intracellular loop of the GABA-A gamma-2 (short) receptor subunit. This physical association enables mutual inhibitory functional interactions between these receptor systems. Pseudogenes related to this gene reside on chromosomes 1 and 2. Defects in DRD5 are a cause of blepharospasm, a primary focal dystonia affecting the orbicularis oculi muscles, usually beginning in middle age. (From LocusLink, Swiss-Prot, OMIM and NCI)"                                                                                                                        
[23696] "The human DTR gene at 5q23 encodes Diphtheria Toxin Receptor, which is a heparin-binding EGF-like growth factor. It is mitogenic for fibroblasts and smooth muscle and may be involved in macrophage-mediated cellular proliferation. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. This mature type I membrane protein is released into the extracellular space and probably binds to a receptor. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23697] "The human DTX1 gene at 12q24.21 encodes Deltex Homolog 1, which is a transcription corepressor. Notch1 activates CSL by displacing corerepssors and recruiting coactivator. The N terminus of Deltex Homolog 1 directly interacts with the Notch1 ankyrin repeats, and specifically prevents the recruitment of coactivators and limits CSL activation below the threshold needed for induction of T cell fate. Deltex Homolog 1 may also actively promote B cell fate in common lymphoid progenitors. This protein is expressed in T lymphocytes at all stages of development. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                     
[23698] "The DUSP1 gene encodes Dual Specificity Phosphatase 1, the expression of which is induced by oxidative stress and heat shock. This protein specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. (from LocusLink and Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                              
[23699] "The human TGBF4 gene at 12q24.21 encodes TGF-Beta 4, which is a member of the TGF-beta family of proteins. This protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. It is transiently expressed before and during menstrual bleeding and may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                               
[23700] "The human ECGF1 gene at 22q13.33 encodes Endothelial Cell Growth Factor 1 (Platelet-Derived), which catalyses the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. This protein may have a role in maintaining the integrity of the blood vessels. It promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting only on endothelial cells. It also limits glial cell proliferation as gliostatin. Defects in ECGF1 are the cause of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), an autosomal recessive human disease associated with multiple deletions of skeletal muscle mitochondrial DNA (MTDNA). (From LocusLink, Swiss-Prot and NCI)"                                                                                                   
[23701] "The human EDN2 gene at 1p34 encodes Endothelin-2, a macrophage chemoattractant. Endothelins are endothelium-derived vasoconstrictor peptides. The expression of this secreted protein by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23702] "The EGF gene encodes Epidermal Growth Factor, which has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin. The EGF precursor is believed to exist as a membrane-bound molecule that is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23703] "The human EGFL6 gene at Xp22 encodes Epidermal Growth Factor-Like Protein 6, which is a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. This glycoprotein contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an Arg-Gly-Asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                              
[23704] "The human EHF gene at 11p12 encodes ETS Homologous Factor, which is a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). This protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. Dot blot analysis detects high levels of EHF expression in salivary gland, prostate, and trachea, with lower levels detected in colon, mammary gland, pancreas, lung, stomach, appendix, fetal kidney, and fetal lung. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                               
[23705] "The human EMILIN gene at 2p23.3-p23.2 encodes Elastin Microfibril Interface Located Protein, which is an extracellular matrix glycoprotein found between amorphous elastin and microfibrils. This protein may play a role in elastin deposition. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23706] "This gene encodes Ephrin Receptor Epha2 that binds ephrin-A ligands. EphA2 is overexpressed in many cancers, including 40% of breast cancers.  EphA2 can also transform breast epithelial cells in vitro to display properties commonly associated with the development of metastasis. (from Microsc Res Tech 2002 Oct 1;59(1):58-67)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23707] "This gene encodes Eph-related receptor tyrosine kinase A4.  Semms to have a function in axon guiding and development of the corticospinal tract. (LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23708] "The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23709] "This gene encodes Eph-related receptor tyrosine kinase B1; which may have a role in neurogenesis (Proteome Summary, from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23710] "This gene encodes Ephrin Receptor EphB2; which may have a role in neurogenesis (Proteome Summary, from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23711] "This gene encodes Ephrin Receptor EphB3, may have a role in cell migration in the gut."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23712] "This gene encodes epidermal growth factor receptor pathway substrate 15 that plays a role in normal and neoplastic cell proliferation. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23713] "This gene encodes epidermal growth factor receptor pathway substrate 8 that plays a role in normal and neoplastic cell proliferation. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23714] "This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Several alternatively spliced transcript variants encoding different isoforms exist. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23715] "Human EPS8L2 Gene encodes EPS8-Related Protein 2, a protein of unknown function related to EGFR Pathway Substrate 8 (EPS8), a substrate for the EGFR. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23716] "This gene encodes epidermal growth factor receptor pathway substrate 8-like protein 3 that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Several alternatively spliced transcript variants encoding different isoforms exist. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23717] "ERBB2 interacting protein; acts as an adaptor for the receptor ERBB2/HER2, which may assist in their localization and signalling function; has a PDZ domain and sixteen leucine-rich repeats (LRRs) (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23718] "Encodes epiregulin, a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23719] "Encodes Ets2 repressor factor, a transcriptional repressor; suppresses ets-induced transformation; contain an Ets-domain (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23720] "This gene encodes Ets variant protein1 that belongs to DNA-binding protein of the ETS family.(LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[23721] "Member of the ets DNA binding protein family; may bind the adenovirus E1A enhancer. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23722] "Expressed as a 2.1-kb transcript in bone marrow, peripheral mononuclear cells, and fibroblasts, human EVI2B Gene encodes 448-aa 49-kDa (precursor) EVI2B Protein, a Pro-rich type I membrane protein containing an N-terminal signal peptide, an extracellular domain with 4 potential glycosylation sites, a hydrophobic transmembrane domain, and a hydrophilic cytoplasmic domain. EVI2B is located between 2 translocation breakpoints in an NF1 intron with EVI2A and OMGP; all are transcribed toward the centromere, opposite to transcription of the NF1 gene. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                       
[23723] "Human EXTL1 Gene (EXT Family) encodes 676-aa 75-kDa Exostosin-Like 1, a type II membrane protein glycosyltransferase of the endoplasmic reticulum with strong sequence similarity to EXT1 and EXT2 and likely involved in chain elongation during heparan sulfate and heparin biosynthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23724] "Ubiquitously expressed as a 3.4-kb transcript, 5-exon human EXTL2 Gene (EXT Family) encodes 330-aa 37.5-kDa Exostosin-Like 2, a type II membrane protein glycosyltransferase of the endoplasmic reticulum that initiates heparan sulfate/heparin biosynthesis by alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate and heparin chains. A soluble EXTL2 form, derived from proteolytic processing of the membrane form, is found in serum. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23725] "Ubiquitously expressed as 6.2- and 4.7-kb transcripts, human EXTL3 Gene (EXT Family) encodes 919-aa 105-kDa Exostosin-Like 3, a type II membrane protein glycosyltransferase of the endoplasmic reticulum likely involved in chain initiation and elongation during heparan sulfate/heparin biosynthesis. EXTL3 contains a highly conserved C-terminal region, common to other EXT proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23726] "Expressed in platelets and vascular endothelia, human F2R Gene (GPCR1 Family) encodes 425-aa 47-kDa (precursor) Coagulation Factor II Receptor, a 7-transmembrane G-protein coupled high affinity activated thrombin receptor that stimulates phosphoinositide hydrolysis in the cellular thrombotic response. F2R appears to play a role in platelet activation and vascular development. Receptor phosphorylation probably mediates desenzitization prior to uncoupling and internalization. Activated protein C uses EPCR as a coreceptor for cleavage of Coagulation Factor II Receptor on endothelia. Proteolytic cleavage of F2R generates a new N-terminus that functions as a tethered ligand. (NCI)"                                                                                                                                                                                                                                                                                       
[23727] "Widely expressed, human FADD Gene at 11q13.3 encodes 208-aa 23-kD adaptor protein Fas-Associated Via Death Domain, containing a DED domain, that interacts through its C-terminal death domain with the death domain of cell surface TNFRSF6/FAS-receptor, TNFR, TNFR-2, TNFRSF25, or TNFSF10/TRAIL-receptor and mediates apoptotic signals initiated by these receptors. Interaction with receptor unmasks the FADD N-terminal effector domain allowing it to recruit caspase-8 or caspase-10 and activate the cysteine protease cascade mediating apoptosis. FADD appears required in early T cell development and interacts with CFLAR and PEA15. (NCI)"                                                                                                                                                                                                                                                                                                                                         
[23728] "With a 5-prime GC-rich region characteristic of a housekeeping gene and expressed in testis, thymus, and lymphoblasts, human FANCG Gene at 9p13 encodes 622-aa 68.5-kD DNA Repair Protein XRCC9, containing an N-terminal leucine-zipper motif and belonging to a multisubunit nuclear protein complex with PHF9, FANCA, FANCC, FANCE, and FANCF. Implicated in interstrand DNA cross-link repair and in maintenance of normal chromosome stability, FANCG may operate in postreplication repair or in a cell cycle checkpoint. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23729] "The protein encoded by this gene is thought to play a role in coupling hepatocyte growth factor receptor signaling to the p70 S6 protein kinase pathway. It also interacts with the peptidyl prolyl isomerase FK506-binding protein 59 (FKBP59), FKBPP52 and FKBP12. FKBPs belong to the large family of immunophilins that bind the macrolide immunosuppressant drugs FK506 and rapamycin. This gene has two alternatively spliced transcript variants encoding different isoforms. There is evidence for another polyadenylation site further downstream for this gene.(LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                               
[23730] "Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas, human FASTK Gene (Ser/Thr PK Family) at 7q35 encodes 3 alternative isoforms of 549-aa 61-kD Fas-Activated Serine/Threonine Kinase. Rapidly activated during Fas-mediated apoptosis, serine/threonine dephosphorylated FASTK phosphorylates TIA1, a key apoptosis-promoting nuclear RNA-binding protein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23731] "Human FGF1 Gene at 5q31 encodes Fibroblast Growth Factor 1, a modifier of endothelial cell migration and proliferation that may be important in neovascularization.  Acidic Fibroblast Growth Factor and alpha-ECGF are derived from FGF1 by posttranslational processing.  FGF1 causes the foregut endoderm to develop into the liver.  The hepatogenic response is restricted to endoderm tissue, which selectively co-expresses FGF receptors 1 and 4.  Different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis.  FGF1 binding to FGFR2 is accompanied by binding of a heparin decasaccharide. (NCI)"                                                                                                                                                                                                                                                                                                                                       
[23732] "The 53-kb 3-exon human FGF10 Gene (FGF Family) at 5p13-p12 encodes secreted 208-aa 23-kDa (precursor) Fibroblast Growth Factor 10, containing 2 putative N-glycosylation sites, a heparin binding domain, and several putative phosphorylation sites and is involved in epidermal brain, lung, and limb bud morphogenesis. Most similar to FGF7, FGF10 is mitogenic in the lung and for keratinizing epidermal cells. FGF10 also appears to be involved tissue repair/wound healing. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23733] "Expressed in brain, 3-exon human FGF20 Gene (FGF Family) at 8p22-p21.3 encodes 211-aa 23.5-kDa Fibroblast Growth Factor 20, containing a strong hydrophobic region in its FGF core domain and a weak hydrophobic N terminal region. FGF20 may enhance the survival of midbrain dopaminergic neurons. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23734] "Human FGF21 Gene (FGF Family) at 19q13.1-qter encodes 209-aa 22-kDa (precursor) Fibroblast Growth Factor 21. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23735] "Human FG8F Gene (FGF Family) at 10q24 encodes alternative isoforms FGF-8A, FGF-8B, FGF-8E, and FGF-8F of secreted autocrine androgen-induced Fibroblast Growth Factor 8, which may be involved in angiogensis and/or act as an embryonic epithelial factor in midbrain and limb development, in organogenesis, in gastrulation, and in left-right axis determination. Additional isoforms may exist. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23736] "Expressed in brain, kidney, testis, and widely in fetal tissues, human FGFR3 Gene (FGFR Family) at 4p16.3 encodes 3 alternative isoforms of highly conserved type I membrane protein Fibroblast Growth Factor Receptor 3, consisting of an acidic- and basic-FGF binding extracellular region (containing 3 Ig C2-type domains), a transmembrane segment, and a cytoplasmic tyrosine kinase domain that activates downstream signal cascades involved in mitogenesis and differentiation, as well as bone development and maintenance. FGFR3 defects cause achondroplasia, crouzon syndrome, thanatophoric dysplasia, coronal synostosis, hypochondroplasia, bladder and cervix cancers. (NCI)"                                                                                                                                                                                                                                                                                                     
[23737] "The 6-exon human FGFRL1 Gene (FGFR Family) at 4p16 encodes 504-aa 54.6-kDa conserved Fibroblast Growth Factor Receptor-Like 1, consisting of an extracellular region (containing 3 Ig-like domains), a hydrophobic transmembrane segment, and a cytoplasmic tail lacking a tyrosine kinase domain. This protein may interact with other family members and inhibit growth factor signaling. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23738] "This gene encodes a member of the four-and-a-half-LIM domain (FHL) protein family, which are expressed in a tissue- and stage-specific manner, have been reported to function as transcriptional coactivators. Expression of DRAL (FHL2) results in enhancement of NF-kappaB activation.  DRAL (FHL2) is a p53-responsive gene implicated in induction of apoptosis.  DRAL may participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappaB transcription factor. (from J Biol Chem 2002;277:37045-53 and FEBS Lett 2002;521(1-3):165-9)"                                                                                                                                                                                                                                                                                                                                                                                                                      
[23739] "Encodes acidic fibroblast growth factor intracellular binding protein; may mediate the mitogenic properties associated with acidic FGF1. (Proteome Summary from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23740] "This gene encodes a protein similar to thrombospondin type 1 domain-containing proteins. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases. The function of this protein has not been determined."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23741] "Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart, human FLRT3 Gene (FLRT Family) at 20p11 encodes 649-aa 73-kDa (precursor) Leucine-Rich Repeat Transmembrane Protein FLRT3, a probable type I membrane protein containing a fibronectin type III domain and 10 leucine-rich repeats that may have a function in cell adhesion and/or receptor signaling. FLRT3 resembles small leucine-rich proteoglycans found in the extracellular matrix and shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                      
[23742] "This gene encodes FMS-related tyrosine kinase3, a growth factor receptor in hematopoietic stem and progenitor cells. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23743] "This gene encodes FMS-related receptor tyrosine kinase 4; a endothelial cell-specific receptor; and is similar to vascular endothelial growth factor VEGF (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23744] "The 13-exon 40-kb human FGFR1OP Gene at 6q27 encodes ubiquitous 399-aa 43-kDa hydrophilic FGFR1 Oncogene Partner protein, containing N- and C-terminal alpha helices harboring leucine-rich repeats. t(6;8)(q27;p11), fusing FOP and FGFR1, has been found in myeloproliferative disorders. The chimeric protein contains the N-terminal FOP leucine-rich region fused to the FGFR1 catalytic domain. FOP may play a role in erythroid cell proliferation and differentiation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23745] "This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23746] "Formyl peptide receptor 1, a G protein-coupled receptor; binds bacterial N-formyl-methionyl peptides (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23747] "FRAG1 has been found fused to the C terminus of FGFR2 in rat osteosarcoma cells where it drastically stimulates the transforming activity and autophosphorylation of the receptor.  Human FRAG1 encodes a novel membrane-spanning protein that localizes to chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and a region of frequent loss of heterozygosity in multiple tumor types. (from Proc Natl Acad Sci 1996;93:8956-61 and Genomics 1999;62:59-66)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23748] "The gene FRAT1 (for 'frequently rearranged in advanced t-cell lymphomas') was identified as one that is frequently mutated by proviral insertion during later stages of T-cell lymphomagenesis in mouse systems. All proviral insertions left the coding domain intact, suggesting that it is overexpression of the normal gene that contributes to transformation. The human FRAT1 gene was cloned using the mouse gene as a probe. It encodes a polypeptide of 279 amino acids that is 79% identical to the mouse protein. Human FRAT1 promotes carcinogenesis through activation of the WNT signaling pathway. The protein can bind to glycogen synthase kinase-3 (GSK-3) and Dishevelled, two proteins involved in WNT signal transduction. (from OMIM 602503, Int J Oncol 2002;20:785-9 and Gene 2002;291:17-27)"                                                                                                                                                                              
[23749] "Human FRK Gene (SRC Family) at 6q21-q22.3 encodes 505-aa 58-kDa FYN-Related Kinase (tyrosine kinase), containing a putative ATP-binding motif, tyrosine kinase motifs, and SH2 and SH3 domains. FRK lacks a myristylation signal, has autophosphorylation activity, is C-terminal tyrosine phosphorylated by CSK, and may function during G1/S and suppress growth. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23750] "Human FRSB Gene at 2q36.1 encodes the non-catalytic beta subunit of heterodimeric (alpha/beta) 2 Phenylalanyl-tRNA Synthetase. The two subunits are coordinately overexpressed in an acute-phase chronic myeloid leukemia cell line. (Biochem Biophys Res Commun 1999;255:765-73)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23751] "Follistatin-like-3 (FSTL3) is a secreted glycoprotein that binds to activin and is highly homologous to follistatin, an activin ligand. It is a member of the follistatin-module protein family, which is composed of extracellular matrix-associated glycoproteins thought to act in a paracrine manner to bind morphogens or growth/differentiation factors and regulate their activity during development. In addition to the t(11;19) translocation in a case of B-cell chronic lymphocytic leukemia from which FSTL3 was isolated, rearrangement of the FSTL3 gene was also observed in a case of B-cell non-Hodgkin lymphoma and in a case of B-cell mantle zone lymphoma, suggesting that FSTL3 may be involved in the leukemogenesis process.(OMIM)"                                                                                                                                                                                                                                        
[23752] "A candidate tumor suppressor gene identified in the 120 kb 3p21.3 critical region contained in nested lung and breast cancer homozygous deletions. Overexpression of Fus1 protein significantly inhibited tumor cell growth by induction of apoptosis and alteration of cell cycle processes in 3p21.3 120-kb region-deficient (homozygous) non-small cell lung cancer cell lines (from Cancer Res 2002;62:2715-20)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23753] "Identified as the fusion partner of a J-kappa segment translocation in a follicular lymphoma.  This evolutionarily conserved gene, termed FVT1 for follicular-variant-translocation gene, codes for a putatively secreted protein of 36 kd that was not homologous with any described protein. It was weakly expressed in all the analyzed normal hematopoietic tissues but showed a very high rate of transcription in some T-cell malignancies and in phytohemagglutinin-stimulated lymphocytes. (from OMIM 136440)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23754] "The human FZD2 gene at 17q21.1 of the frizzled gene family encodes Frizzled 2, which is a 7-transmembrane domain protein that is a receptor with a role in transmembrane signal transmission for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23755] "The human FZD3 gene at 8p21 encodes Frizzled 3, which is a G protein-coupled receptor for Wnt proteins and regulates signal transduction in endothelial cells via beta-catenin. It may function in both normal and pathological vasculature differentiation. It also may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Two isoforms are produced by alternative splicing. This protein is widely expressed with relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                    
[23756] "The human FZD4 gene at 11q14.2 encodes Frizzled 4, which is a G protein-coupled receptor that has seven transmembrane domains. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. It may function in cell polarity, cell fate specification and cancer. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23757] "The human FZD6 gene at 8q22.3-q23.1 encodes Frizzled 6, which is a G protein-coupled receptor for Wnt signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other Fz family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif. Frizzled 6 may function in tissue polarity, development and carcinogenesis. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23758] "The human FZD7 gene at 2q33 encodes Frizzled 7, which is a G protein-coupled receptor for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression downregulates APC function and enhances beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23759] "The human FZD9 gene at 7q11.23 encodes Frizzled 9, which is a G protein-coupled receptor for Wnt signaling proteins. This gene has been first described as FZD3 in literature. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. Frizzled 9 may function in tissue polarity, development and carcinogenesis. Heterozygous deletion of the FZD3 gene may contribute to the Williams syndrome phenotype. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23760] "The human GAB2 gene at 11q13.3 is a member of the GRB2-associated binding protein (GAB) gene family and encodes GRB2-Associated Binding Protein 2 (GAB2). GAB2 is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Upon tyrosine phosphorylation, GAB2 interacts with SHP2 tyrosine phosphatase and GRB2 adapter protein. It is the limiting component of the GAB2-SHP2 complex, signaling Erk MAP kinase activation and terminal differentiation of K562 CML cells. GAB2 also has an inhibitory effect on the activation of ELK1-dependent transcription triggered by a dominant active Ras mutant or under growth factor stimulation. Two alternatively spliced transcripts encode different isoforms and the short isoform is the main isoform. This protein is overexpressed and estrogen regulated in human breast cancer. (From LocusLink, OMIM and NCI)"                                                                
[23761] "The human GAC1 gene at 1q32.1 encodes Glioma Amplified on Chromosome 1 Protein, which belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. GAC1 has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23762] "The GADD45A gene at 1p31.2-p31.1 encodes Growth Arrest and DNA-Damage-Inducible, Alpha, which is widely expressed in normal tissues and its expression is increased by DNA damage. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. The GADD45A protein responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. This nuclear protein interacts with the proliferating cell nuclear antigen (PCNA), a component of DNA replication/repair complexes, and the cyclin dependent kinase inhibitor p21Cip1."                                                                                                                                                                                                                                                                                                                                                                            
[23763] "Human GALR2 Gene at 17q25.3 encodes 387-aa 42-kDa Galanin Receptor 2, a GPCR for neuromodulatory peptide galanin that stimulates growth hormone secretion, inhibits vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. Galanin Receptor 2 decreases cAMP through an inhibitory G-protein and stimulates phospholipase C and mobilizes calcium through Gq/G11. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23764] "The human GAS41 gene at 12q13-q15 encodes Glioma-Amplified Sequence-41, which may be a transcription factor and common binding factor for the TACC family proteins. An increased copy number of this gene is found in glioblastoma multiforme and astrocytoma III, and at a high frequency in astrocytoma grades I and II. The GAS41 gene is the first gene found with increased copy number in low-grade glioma, which provides the first evidence that gene amplification can occur in early tumor development. (From OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23765] "The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                            
[23766] "The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23767] "The human GDF5 gene at 20q11.2 encodes Growth Differentiation Factor 5, which is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein is predominantly expressed in long bones during human embryonic development. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23768] "The human GDF8 gene at 2q32.2 encodes Growth Differentiation Factor 8, which is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein plays a role in the control and maintenance of skeletal muscle mass. It acts specifically as a negative regulator of skeletal muscle growth by signaling through receptor serine/threonine kinases. This protein is synthesized as a preprotein activated by 2 proteolytic cleavages. Removal of the signal sequence is followed by cleavage at a tetrabasic processing site, resulting in a 26-kD amino-terminal propeptide and a 12.5-kD carboxy-terminal peptide, a dimer of which is the biologically active portion of the protein. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                         
[23769] "The human GDF9 gene at 5q31.1 encodes Growth Differentiation Factor 9, which is a member of the TGF-beta superfamily. This protein interacts with bone morphogenetic protein-15 and Bone morphogenetic protein receptor type II is a receptor for Growth Differentiation Factor-9. Both GDF9 mRNA and protein are abundantly expressed in oocytes of primary follicles in human ovary, suggesting that the GDF9 transcript is translated at this early stage of folliculogenesis. GDF9 is crucial for normal ovarian folliculogenesis and female fertility. GDF9 regulates human folliculogenesis in a manner specific to the ovary. A dysregulation of GDF9 expression may contribute to aberrant folliculogenesis in PCOS and PCO women. (From OMIM, Swiss-Prot and NCI)"                                                                                                                                                                                                                         
[23770] "The human GFI1B gene at 9q34.13 encodes Growth Factor Independence-1B, which is a zinc finger protein. This protein is a transcription factor with specific involvement in the regulation of erythroid cell growth in normal erythropoiesis through modulating erythroid-specific gene expression. The function of GFI1B to modulate transcription depends on promoter context. Human GFI1B expression by Northern blot analysis is highest in bone marrow and fetal liver as well as in the chronic myeloid leukemia cell line K562 with lower levels in other hematopoietic precursor cells. Expression of GFI1B is highly restricted to hematopoietic stem cells, erythroblasts, and megakaryocytes. Its expression does not promote erythroid commitment, but enhances proliferation of immature erythroblasts. The chromosomal region of this gene is translocated to chromosome 22q11 in chronic myeloid leukemia (From OMIM, PubMed 12351384 and NCI)"                                       
[23771] "The human GFRA2 gene at 8p21 encodes GDNF Family Receptor Alpha 2, which is a member of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) Receptor family. GDNF and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 is required for the development of the myenteric nerve plexus. This protein is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This receptor acts preferentially as a receptor for NTN compared to its other family member, GDNF Family Receptor Alpha 1. Two alternatively spliced transcript variants, long and short, have been described for this gene but their full length nature is not known. The short form is found in brain and placenta. This gene is a candidate gene for RET-associated diseases. (From LocusLink, OMIM, Swiss-Prot and NCI)"
[23772] "This gene encodes gastric inhibitory polypeptide (glucose-dependent insulinotropic polypeptide) receptor; signals through stimulatory G-protein to increase intracellular cAMP; member of the G protein-coupled receptor family. (Proteome Summary from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23773] "This gene encodes G Protein-Coupled Receptor Kinase-Interactor 1: GIT1 is a multidomain protein that is thought to function as an integrator of signaling pathways controlling vesicle trafficking, adhesion and cytoskeletal organization. (from J Cell Sci 2002 Apr 1;115(Pt 7):1497-510)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23774] "This gene encodes a member of the GIT protein family. GIT proteins interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. This gene undergoes extensive alternative splicing. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23775] "Human GLI1 Gene (GLI/Kr family) at 12q13.2-q13.3 is homologous to Ci (Drosophila), which encodes a gap class chromatin-associated phosphoprotein.  GLI1 encodes GLI1 Protein, containing five DNA-binding C2H2 zinc finger repeats implicated in transcription of SHH signaling target genes; a putative endodermal signal that controls hindgut patterning and lung growth.  Kr family members are expressed in embryonic cells, but not in most adult tissue.  (from SWISS-PROT, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23776] "The human GLTSCR1 gene at 19q13.3 encodes Glioma Tumor Suppressor Candidate Region Gene 1 Protein. Northern blot analysis detects expression of a 6.5-kb GLTSCR1 transcript at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver, and kidney. Mutation analysis of the transcripts in this region in diffuse gliomas with 19q deletions reveals no tumor-specific mutations. However, a marker in GLTSCR1, presumably separated from RAI by several million bases, supplements the most significant marker in RAI in separating cases of basal cell carcinoma (BCC) from controls, which may suggest the presence of an independent, risk-modulating variation in this second gene region. (From OMIM, Swiss-Prot, PubMed 12117772 and NCI)"                                                                                                                                                                                             
[23777] "The human GLTSCR2 gene at 19q13.3 encodes Glioma Tumor Suppressor Candidate Region Gene 2 Protein, which interacts with HSV-1 early proteins ICP22 and ICP0. Northern blot analysis detects expression of a 1.5-kb GLTSCR2 transcript at high levels in heart and pancreas, moderate levels in placenta, liver, skeletal muscle, and kidney, and low levels in brain and lung. Mutation analysis of the transcripts in this region in diffuse gliomas with 19q deletions reveals no tumor-specific mutations. (From OMIM, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23778] "G-protein alpha subunit 12; couples to thrombin and thromboxane A2 receptors in platelets (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23779] "Single copy human GNAI2 Gene (G-Alpha 1 Family) encodes 354-aa 40-kDa G(i) Alpha 2 Protein, a guanine nucleotide-binding alpha protein subunit of heterotrimeric G protein transducers (alpha, beta, gamma) in transmembrane signaling systems involved in hormonal regulation of adenylate cyclase. At least 3 nonallelic human genes encode alpha-i-type G protein subunits; GNAI2 and GNAI3 possess identical exon-intron organization. Containing virtually identical/similar beta and gamma chains, G proteins are most distinguished by alpha chains. G(i) proteins (alpha(i) subunit) inhibit cyclase in response to beta-adrenergic stimuli. Specific alpha chain regions appear to interact with guanine nucleotides, receptors, effector enzymes, and G protein beta-gamma complex. G proteins that inhibit adenylate kinase are substrates for pertussis toxin. GNAI2 mutations affect cell proliferation. (NCI)"                                                                        
[23780] "Guanine nucleotide binding protein is a member of a G protein subfamily that mediates signal transduction; component of pertussis toxin-insensitive (PTX) heterotrimeric G-protein complexes. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23781] "Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23782] "With an upstream CCG repeat length polymorphism and expressed in oocytes and blastocysts, human GNB2 Gene at 7q22 encodes 340-aa 37-kDa Guanine Nucleotide Binding Protein Beta 2, a heterotrimeric G protein beta subunit with 7 WD repeats and involved in transmembrane signaling as a transducer that regulates G protein alpha subunits and integrates signals between receptors and effector proteins. The G protein beta and gamma subunits are required for GTPase activity, for GTP replacement of GDP, and for G protein/effector interaction. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23783] "Human GNB3 Gene at 12p13 encodes 340-aa 37-kDa Guanine Nucleotide Binding Protein Beta 3, a heterotrimeric G protein beta subunit with 7 WD repeats and involved in transmembrane signaling as a transducer that regulates G protein alpha subunits and integrates signals between receptors and effector proteins. The G protein beta and gamma subunits are required for GTPase activity, GTP for replacement of GDP, and for G protein/effector interaction. A splicing-associated single-nucleotide polymorphism (C825T) is associated with essential hypertension and obesity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                          
[23784] "The glycoprotein encoded by this gene is a cell surface antigen that is expressed in normal human colon and small intestine epithelia and in greater than 95% of human colon cancers. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. It may function as a cell surface receptor or play a role in cell adhesion. (LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                       
[23785] "Expressed in brain, human GPR17 Gene (GPCR1 Family) at 2q21 encodes in 2.3-/6.3-kb mRNAs alternative isoforms 1 and 2 of 339-/367-aa 41-kDa integral membrane protein G Protein-Coupled Receptor 17, a putative purine receptor containing 7 transmembrane domains that transduces extracellular signals through heterotrimeric G proteins. GPR17 gene organization differs from many other GPCRs; the open reading frame is distributed on 2 exons with an additional 5-prime UTR exon. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23786] "The GPR2 gene encodes G Protein-Coupled Receptor 2, which is the receptor for CCL27. The interactions between this receptor and CCL27 are involved in T cell-mediated skin inflammation. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23787] "Human GPR32 Gene (GPCR1 Family) at 19q13.3 encodes 356-aa 40-kDa integral membrane protein G Protein-Coupled Receptor 32, an orphan receptor with greatest similarity to chemoattractant receptors, particularly the formylpeptide receptor (FPR1). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23788] "Expressed as a 3-kb transcript in spleen, testis, peripheral leukocytes, brain, lung, and placenta, GPR68 Gene (GPCR1 Family) at 14q31 encodes 365-aa 41-kDa 7-transmembrane G Protein-Coupled Receptor 68, a high affinity receptor for sphingosylphosphorylcholine that acts as a proton-sensing receptor and stimulates PI hydrolysis. The receptor is inactive at pH 7.8 and fully activated at pH 6.8; extracellular histidines are involved in pH sensing. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23789] "Encodes CD183, a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to CD183. A hallmark of CD183 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that CD183 and its chemokines participate in the recruitment of inflammatory cells. (from LocusLink)"                                                                            
[23790] "Expressed in stomach, kidney, liver, lung, pancreas, central nervous system, and prostate, human GPRC5C Gene (GPCRc Family) at 17q25 encodes 441-aa 48-kDa 7-transmembrane G Protein-Coupled Receptor Family C Group 5 Member C, with an extracellular N-terminal domain, an intracellular C-terminal domain, and conserved cysteines residues. The specific protein function is unknown; it may mediate retinoic acid effects on G protein signal transduction. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23791] "Expressed primarily in testis and brain, 16-exon 75-kb human GPRK2L Gene (GPRK Family) at 4p16.3 encodes 4 alternative isoforms (GRK4A, B, C, D) of 578-/546-/532-aa 67-kDa G Protein-Coupled Receptor Kinase 2-Like, a Ser/Thr kinase containing an RGS domain that phosphorylates activated GPCRs and may play a role in receptor desensitization. Only full-length GRK4D has kinase activity, can phosphorylate rhodopsin, and is inhibited by calmodulin. The other isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23792] "Expressed in heart, placenta, lung, skeletal muscle, brain, liver, pancreas, and kidney, human GPRK5 Gene (GPRK Family) at 10q24-qter encodes 590-aa 68-kDa G Protein-Coupled Receptor Kinase 5, which contains an RGS domain and specifically Ser/Thr phosphorylates and regulates activated forms of GPCRs. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23793] "The GPRK6 gene encodes G Protein-Coupled Receptor Kinase 6, which belongs to the GPRK subfamily of the Ser/Thr family of protein kinases. It specifically phosphorylates the activated forms of G protein-coupled receptors. Two alternative splicing forms exist. (from Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23794] "Expressed in retina, 4-exon 10-kb human GPRK7 Gene (GPRK family) at 3q23 encodes membrane-bound 553-aa 62-kDa G Protein-Coupled Receptor Kinase 7, a Ser/Thr kinase containing an RGS domain, a C-terminal CaaX motif for isoprenylation and carboxymethylation, an autophosphorylation site (Ser491), and a geranylgeranylation motif. GRK7 catalyzes rhodopsin phosphorylation, initiating their deactivation in a light-dependent manner. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23795] "Human GPS1 Gene at 17q25.3 encodes 471-aa 53-kDa G Protein Pathway Suppressor 1 Protein, containing a PCI domain and with similarity to signal transduction regulator FUS6 (Arabidopsis). GPS1 suppresses G-protein- and MAP kinase-mediated signal transduction. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23796] "Human GPS2 Gene at 17p13 encodes 2 isoforms of 327-aa 37-kDa G Protein Pathway Suppressor 2 Protein, a protein that suppresses RAS and MAP kinase signal transduction and interferes with c-JNK activation. GPS2 is an integral subunit of NCOR1/HDAC3 complex. GPS2 and TBL1 in NCOR1/HDAC3 interact with NCOR1 repression domain-1 to link to HDAC3 via the NCOR1 SANT domain, which activates HDAC3 activity. NCOR1/HDAC3 inhibits JNK activation through GPS2. GPS also interacts with E2 and E6 proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23797] "Normally expressed in early fetal development, human GR6 Gene at 3q21 in the leukemia breakpoint region encodes 149-aa 16-kDa GR6 Protein, function unknown. (from Cancer Res 1997;57:3914-9)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23798] "This gene encodes a member of the GRB2/Sem5/Drk family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. Expression is restricted to lymphoid tissues.(LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                             
[23799] "This gene encodes growth factor receptor-bound protein 10. This gene product interacts with IGF1R, PDGFRB, and EGFR and binds to the Raf-1 and MEK1 kinases. Its cellular role is still unclear and a positive as well as an inhibitory role in mitogenesis depending on the cell context has been implicated.  Grb10 may regulate signaling between plasma membrane receptors and the apoptosis-inducing machinery on the mitochondrial outer membrane. (from LocusLink, J Biol Chem 1999;274:35719-24, and Mol Cell Biol 1999;19:6217-28)"                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23800] "Member of the GRB7 family of adapter proteins; identified as a partner of the insulin receptor where it acts as a modulator of insulin signaling. (from J Biol Chem 2002;277:4845-52)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23801] "GRB2 is the homolog of the Sem5 gene of C. elegans and the Drk gene of Drosophila. GRB2 forms a complex with activated EGFR and the RAS-specific guanine nucleotide exchange factor SOS1, thereby mediating the growth factor-induced activation of RAS. It also acts to link PDGFRB to the Rac signaling pathway. Due to its ability to cause complex formation between proteins involved in growth signaling pathways, GRB2 has been referred to as an adaptor protein. (from LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23802] "This gene encodes growth factor receptor-bound protein 7. It is an adapter-type signaling protein, which is recruited via its SH2 domain to a variety of receptor tyrosine kinases (RTKs), including ErbB2 and ErbB3. Grb7 has been implicated as a downstream mediator of integrin-FAK signal pathways in the regulation of cell migration, although the molecular mechanisms are still not well understood. It is overexpressed in breast, esophageal, and gastric cancers, and may contribute to the invasive potential of cancer cells.(from J Biol Chem 2002;277:29069-77 and J Biol Chem 2002;277:11918-26)"                                                                                                                                                                                                                                                                                                                                                                                  
[23803] "GRF2 is a human guanine nucleotide releasing protein for Ras protein. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23804] "This gene encodes subunit 3 of the AMPA subtype of ionotropic glutamate receptor; important for excitatory neurotransmission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23805] "This gene encodes metabotropic 1 of glutamate Receptor. The metabotropic glutamate receptors are a family of G protein-coupled neurotransmitter receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23806] "The metabotropic glutamate receptors are a family of G protein-coupled neurotransmitter receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties; activates phospholipase C and calcium-induced chloride channels (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23807] "This gene encodes metabotropic 6 of glutamate Receptor. The metabotropic glutamate receptors are a family of G protein-coupled neurotransmitter receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23808] "This gene encodes glutathione S-transferase theta 1, a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. The theta class includes GSTT1 and GSTT2. In humans, the GSTT1 enzyme is found in the erythrocyte and this may act as a detoxification sink. (LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23809] "The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Overexpression inhibits cell growth and induces apoptosis in tumor cell lines. (from LocusLink and Cancer Res 2002;62:2913-22)"                                                                                                                                                                                                                                                                                                                                                                                           
[23810] "Human Hepatocyte Growth Factor is also known as Scatter Factor and Hepatopoeitin A.  HGF is a potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types, including renal tubular epithelial cells, epidermal keratinocytes and melanocytes.  A single chain precursor is cleaved to 70 kD and 30kD chains that are linked by one disulfide bond. Both the single chain and cleaved form are active."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23811] "HGS encodes hepatocyte growth factor-regulated tyrosine kinase substrate that is a downstream signaling molecule.  It undergoes tyrosine phosphorylation in response to IL2, CSF2, or HGF."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23812] "The 1.4-kb human HHCM Gene at 8q24.3 encodes 467-amino acid 52-kD Hepatocellular Carcinoma Protein HHCM, which appears to have transforming ability on fibroblasts and liver cells. (from LocusLink, Swiss-Prot, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23813] "Expressed in heart, skeletal muscle, and adipose tissue, 58-kb insulin-responsive human HK2 Gene (Hexokinase Family) at 2p12-p13 encodes outer mitochondrial membrane bound 917-amino acid 102-kD monomeric Hexokinase 2; expression supports glycolysis in rapid cancers. p53 regulation may link glycolysis to cell cycle control. Containing many TF motifs, mouse Hk2 produces a 5.5-kb mRNA from 18 exons. TIS and polyadenylation sites resemble rat and human. Polymorphic HK2 CA-repeat and TA-repeat regions exist. HK2 contains glucose- and ATP-binding sites and a hexokinase domain. The C-terminus contains catalytic activity; membrane binding and regulation associate with the N-terminus. Allosterically regulated by product, HK2 converts aldo-/keto-hexoses to hexose-6-phosphate, the first step of many metabolic pathways. Mutations appear not to contribute to NIDDM. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                       
[23814] "Expressing a 2-kb transcript in adipose tissue, neutrophils, and peripheral blood mononuclear cells, the 2-kb human HM74 Gene (GPCR1 Family, Rhodopsin Family) at 12q24.31 encodes Chemokine Receptor HM74, a 387-amino acid 44.5-kD putative G protein-coupled receptor integral membrane protein containing a 7-transmembrane receptor domain and similar to the GPR31 orphan receptor, the B2 bradykinin receptor (BDKRB2), and the thrombin receptor (F2R). HM74 Protein appears to be a nicotinic acid receptor. Binding of nicotinic acid to the mouse ortholog PUMA-G, or to HM74, results in a G protein-mediated decrease in cAMP levels. PUMA-G mediates the anti-lipolytic, lipid-lowering effects of nicotinic acid. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                       
[23815] "Tightly linked to MEN2, the 3-kb human HNRPA3 Gene at 10q11.1 encodes Heterogeneous Nuclear Ribonucleoprotein A3, a putative 379-amino acid 40-kD nuclear protein similar to heterogeneous ribonucleoproteins, putative components of ribonucleosomes, and to rat helix destabilizing, heterogeneous nuclear ribonucleoprotein A1 (HNRPA1). Containing two RNA recognition motifs (RRM), HNRPA3 belongs to the HNRNP A/B group of basic, GLY-rich proteins. Defects in this gene may cause multiple endocrine neoplasia IIA. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                           
[23816] "Human HOXA10 Gene (ABD-B Family) at 7p15-p14.2 resides within the 90-kb HOXA cluster of eight tandem homeobox genes. Encoding 496- and 494-amino acid 41-kD inhibitory DNA-binding Homeobox Protein A10 transcription factors, alternatively spliced 2.2- (isoform B) and 3.0- (isoform A) kb transcripts link differing 5-prime regions to a common 3-prime homeobox domain. Expressed spatially/temporally in posterior domains during genitourinary development, HOXA10 may regulate morphogenesis and differentiation by providing anterior-posterior positional identity. Stimulated by estrogen or progesterone, HOXA10 is expressed in adult endometrium during early pregnancy. Bound to 5-prime AA[AT]TTTTATTAC 3-prime DNA, HOXA10 may mediate progesterone regulation of uterine EP3 and EP4. HOXA10 also appears to regulate hematopoietic lineage commitment. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                             
[23817] "Human HOXA9 Gene (ABD-B Family) at 7p15-p14.2 resides within the 90-kb HOXA cluster of eight tandem homeobox genes and encodes 272-amino acid 30-kD Homeobox Protein A9 isoforms, class I sequence-specific DNA-binding homeobox transcription factors potentially involved in morphogenesis and myeloid differentiation; expression is spatially and temporally regulated during embryonic development. Frameshifted transcript variant 2 encodes isoform B containing a distinct C-terminus that lacks the homeodomain. HOXA9 acts within a developmental regulatory system that provides specific anterior-posterior positional identities to cells. Associated with acute myeloid leukemogenesis, t(7;11)(p15;p15) fuses the nucleoporin NUP98 amino terminal half in-frame to HOXA9, which may inhibit differentiation or disrupt nucleocytoplasmic transport. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                    
[23818] "The 14-kb human HOXC6 Gene (ANTP Family) at 12q13.3 resides within the HOXC cluster of tandem homeobox genes encoding highly conserved sequence-specific DNA-binding transcription factors. HOXC5, HOXC4, and HOXC6 are co-transcribed to a primary transcript; some processed transcripts share the 5' non-coding exon. HOXC6 variant 2 transcripts contain a distinct 5' UTR lacking part of an in-frame 5' coding region. The 2.2- and 1.8-kb transcripts encode 153- and 235-amino acid (27-kD) transcription repressors that can cooperate with other HOX proteins and may contribute to the breast cell phenotype through co-operative interactions. As part of a developmental regulatory system that provides anterior-posterior positional identity to cells, Homeobox C6 Protein may regulate the coordinated expression of multiple genes involved in morphogenesis and differentiation. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                    
[23819] "The 8.7-kb human HPCA Gene (Recoverin Subfamily) at 1p35-p34.2 expresses a single 2-kb neuron-specific transcript that encodes 192-amino acid 22-kD myristoylated plasma membrane-associated Hippocalcin, which binds two Ca(2+) ions and contains the EF-hand Ca(2+)-binding motif. Human sequence shows complete amino acid identity and 92% nucleotide identity with rat; it is also identical to mouse hippocalcin protein. Hippocalcin shows striking similarity to photoreceptor Ca(2+)-sensitive proteins that regulate photosignal transduction. Hippocalcin displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase; it may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                          
[23820] "The single copy 43-kb human HPSE Gene at 4q21.3 contains twelve exons expressed as a ubiquitous 4-kb transcript, and as a 2-kb transcript in placenta, peripheral blood leukocytes, spleen, lymph node, bone marrow, fetal liver, and thymus. With hydrophobic stretches suggesting a transmembrane protein and six potential N-glycosylation sites, 543-amino acid Heparanase is an endoglycosidase (beta-glucuronidase) that degrades heparan sulfate and related proteoglycans in the ECM and vascular basal laminar. Heparan sulfate degradation is key in tumor cell and migrating leukocyte extravasation. Heparanase activity is also important in angiogenesis, wound healing, and smooth muscle proliferation. (from LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                                            
[23821] "Expressed in breast, ovaries, pregnant uterus, placenta, testis, thymus, prostate, fetal liver, and some neural tissues, the 22-kb human HSD17B7 Gene (SDR Family) at 1q23 contains nine exons that produce two alternative isoforms, which encode 341-amino acid 38-kD 17-Beta-Hydroxysteroid Dehydrogenase 7. Lymphoid- and brain-specific promoter transcription factor-binding sites exist. Nearly 75% identical to rodent proteins and containing a short chain dehydrogenase domain, the membrane-associated and phosphorylated enzyme oxidizes or reduces estrogens and androgens; it is responsible for biosynthesis of estradiol in the corpus luteum during pregnancy. HSD17B7 contains a 28-residue insert close to the transmembrane domain that forms a superficial loop, a candidate prolactin receptor (PRLR)-binding domain. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                           
[23822] "The 20-kb human tumor suppressor HTATIP2 Gene (SDR Family) at 11p15.1 generates a ubiquitous 1.6-kb transcript that encodes conserved 242-amino acid 30-kD nuclear and membrane-associated TAT-Interacting Protein TIP30. TIP30 contains several conserved features: a semialdehyde dehydrogenase domain, a N-terminal beta-alpha-beta fold that may bind NADP(H), and a unique 20-amino acid N-terminal alpha helix that may enable protein docking. TIP30 proapoptotic activity resides in the N-terminal domain. A 0.8-kb splice variant encodes membrane-associated 133-amino acid TC3 protein with a short, unique C-terminus that confers antiapoptotic properties. TIP30 appears to be a RNA polymerase II transcription co-activator and may function as a co-activator for HIV-1 TAT protein. TIP30 may also suppress metastasis. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                             
[23823] "Controlled by IFN-alpha and -gamma, the two-exon human IFITM1 Gene (IFN-Induced Transmembrane Protein Family) on chromosome 11 encodes 125-amino acid 14-kD Interferon-Induced Transmembrane Protein 1 (Fragilis), a membrane protein component of a multimeric complex involved in transduction of antiproliferative and homotypic adhesion signals. Fragilis appears to demarcate germ cells from somatic neighbors and mark the onset of germ cell competence. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23824] "Situated in a cluster of interferon-alpha and -omega genes and expressed by macrophages, the 0.65 kb human IFNA13 Gene (IFN Alpha Family) at 9p22 encodes a secreted 189-amino acid 21.7 kD Interferon Alpha 13 precursor containing the interferon alpha/beta domain. With telomeric 3-prime ends, the interferon genes exhibit the order: pter-IFNB1-(IFNW1, IFNA21)-IFNWP15-IFNA4-IFNW9-IFNA7-IFNA10-IFNWP18-IFNAP16-IFNA17-IFNA14-(IFNA22, IFNA5, IFNAP20, IFNA6, IFNA13, IFNA2)-(IFNA8, IFNW2, IFNWP19, IFNA1)-MTAP-cen. Interferon Alpha 13 appears to regulate antiviral defense, cell growth, and immune activation; it stimulates the production of a protein kinase and an oligoadenylate synthetase. Interferons Alpha-13 and Alpha-1 have identical protein sequence. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                      
[23825] "Situated in a cluster of interferon-alpha and -omega genes and expressed by macrophages, the 1.1 kb human INFA2 Gene (IFN Alpha Family) at 9p22 generates Alpha-2A, Alpha-2B, and Alpha-2C isoforms that encode a secreted 188-amino acid 21.6 kD Interferon Alpha 2 precursor containing the interferon alpha/beta domain. With telomeric 3-prime ends, the interferon genes exhibit the order: pter-IFNB1-(IFNW1, IFNA21)-IFNWP15-IFNA4-IFNW9-IFNA7-IFNA10-IFNWP18-IFNAP16-IFNA17-IFNA14-(IFNA22, IFNA5, IFNAP20, IFNA6, IFNA13, IFNA2)-(IFNA8, IFNW2, IFNWP19, IFNA1)-MTAP-cen. Exhibiting interferon-alpha/beta receptor ligand activity, Interferon Alpha-2 appears to regulate antiviral defense, cell growth, and immune activation; it stimulates the production of a protein kinase and an oligoadenylate synthetase. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                         
[23826] "Situated in a cluster of interferon-alpha and -omega genes, the 1.5 kb human IFNW1 Gene (IFN Alpha, Beta, Delta Family) at 9p21-p22 encodes a secreted 195-amino acid 22 kD Interferon Omega 1 precursor, a type I interferon protein containing the interferon alpha/beta domain. With telomeric 3-prime ends, the interferon genes exhibit the order: pter-IFNB1-(IFNW1, IFNA21)-IFNWP15-IFNA4-IFNW9-IFNA7-IFNA10-IFNWP18-IFNAP16-IFNA17-IFNA14-(IFNA22, IFNA5, IFNAP20, IFNA6, IFNA13, IFNA2)-(IFNA8, IFNW2, IFNWP19, IFNA1)-MTAP-cen. Interferon Omega-1 appears to regulate antiviral defense, cell growth, and immune activation. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                
[23827] "Ubiquitously expressed as a 1.4-kb mRNA (highest in heart, skeletal muscle, and pancreas), human IGBP1 Gene at Xq13.1-q13.3 encodes 339-aa 39-kDa Immunoglobulin Binding Protein 1, likely involved in IgM/B-Cell Receptor signal transduction. Similar to mouse Igbp1 and yeast TAP42, IGBP1 contains potential N-glycosylation sites, myristylation sites, multiple potential PKC and casein kinase II phosphorylation sites, and an SH3-binding sequence-related stretch. IGBP1 associates with and likely regulates the activity of Ser/Thr phosphatase PP2A-Alpha and PP2A-Beta catalytic subunits. IGBP1 also associates with PP4 and PP6. (NCI)"                                                                                                                                                                                                                                                                                                                                             
[23828] "Encodes Insulin-like growth factor I (somatomedin C); activates cell proliferation and differentiation"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23829] "Insulin-like growth factors I and II, also known as somatomedin C and somatomedin A, respectively, are single chain polypeptides which share an amino acid sequence homology of about 47% with insulin and about 31% with relaxin and with them comprise the insulin family of polypeptide growth factors. Their functions include mediation of growth hormone action, stimulation of growth of cultured cells, stimulation of the action of insulin, and involvement in development and growth. They appear to be autocrine regulators of cell proliferation."                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23830] "Encodes IGF2R, a 250kDa transmembrane protein. It was originally identified as a receptor for IGFII and M6P-containing proteins (e.g. lysosomal hydrolases). Lysosomal enzymes are sorted to lysosomes via IGF2R either from the Golgi, where the enzymes acquire M6P, or from the extracellular space. The majority of IGF2R molecules are located intracellularly, only 5-10% is present on the cell membrane. IGF2R is also a receptor for TGFbeta latency associated peptide (LAP), proliferin and may bind several molecules independently of M6P, including plasminogen, CD87 or retinoic acid. It is involved in activation of latent TGFbeta.  It is a putative hepatocellular tumor suppressor. (from LocusLink)"                                                                                                                                                                                                                                                                          
[23831] "The insulin-like growth factors, their receptors, and their binding proteins play key roles in regulating cell proliferation and apoptosis. Among the several roles of IGFBP3 are its function as the major carrying protein for IGF1 and IGF2 in the circulation, and its action as a modulator of IGF bioactivity and as a direct growth inhibitor in the extravascular tissue compartment, where it is expressed in a highly regulated manner (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23832] "The insulin-like growth factors, their receptors, and their binding proteins play key roles in regulating cell proliferation and apoptosis. IGFBP4 functions as a carrying protein for IGF1 and IGF2 in the circulation, and it acts as an inhibitor of IGF action in tissues. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23833] "The insulin-like growth factors, their receptors, and their binding proteins play key roles in regulating cell proliferation and apoptosis. IGFBP5 may function as a carrying protein for IGF1 and IGF2 in the circulation and it can act as an inhibitor of IGF action."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[23834] "The insulin-like growth factors, their receptors, and their binding proteins play key roles in regulating cell proliferation and apoptosis. Acts as a cell density and Ca+2 dependent inhibitor of cell growth. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[23835] "The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23836] "This gene encodes the alpha subunit of the high-affinity receptor for interleukin-11. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23837] "IL12A (p35) comprises one chain of the heterodimeric IL12. Interleukin-12 is a novel cytokine cloned from B-cell lines. It has a broad array of potent biologic activities, acting at picomolar and subpicomolar levels on both T and NK cells. It stimulates the production of interferon gamma from T-cells and natural killer cells and also induces differentiation of TH1 cells. Sequence comparisons showed that p35 is related in sequence to ligands of the cytokine receptor family, most closely to IL6 and GCSF. On the other hand, p40 is a member of the cytokine receptor family, most closely related to IL6R, and forms a subgroup with IL6R and GCSFR. (from OMIM 161560)"                                                                                                                                                                                                                                                                                                         
[23838] "IL12B (p40) comprises one chain of the heterodimeric IL12. Interleukin-12 is a novel cytokine cloned from B-cell lines. It has a broad array of potent biologic activities, acting at picomolar and subpicomolar levels on both T and NK cells. It stimulates the production of interferon gamma from T-cells and natural killer cells and also induces differentiation of TH1 cells. Sequence comparisons showed that p40 is a member of the cytokine receptor family, most closely related to IL6R, and forms a subgroup with IL6R and GCSFR. On the other hand, p35 is related in sequence to ligands of the cytokine receptor family, most closely to IL6 and GCSF. (from OMIM 161560)"                                                                                                                                                                                                                                                                                                         
[23839] "The IL13 gene at 5q31 encodes Interleukin-13, which is an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. Interleukin-13 is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. (From LocusLink)"                                                                                                                                                                                                                                       
[23840] "Expressed by activated T cells, human IL17C Gene (IL-17 Family) at 16q24 encodes 197-aa 22-kDa (precursor) secreted cytokine Interleukin-17C (IL17-related), which may stimulate release of TNF-alpha and IL-1beta from monocytes in inflammatory immune responses. IL17C differs from IL17 in its pattern of expression, biologic activity, and lack of interaction with IL17 receptor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23841] "The IL2 gene at 4q26-q27 encodes Interleukin-2, which is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.  (From LocusLink)"                                                                                                                                                                                                                                                                                                                     
[23842] "The protein encoded by this gene represents the beta subunit of the interleukin 2 receptor and is a type I membrane protein. It is involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. It plays a role in the T cell mediated immune response and is a member of the cytokine receptor family. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23843] "This gene encodes interleukin 2 receptor gamma chain (IL2RG), which is an important signalling component of many interleukin receptors (IL2,IL4,IL7,IL9, and IL15), is thus referred to as the common gamma chain. It is necessary for normal growth and differentiation of T cells, B cells, natural killer cells, glioma cells, and cells of the monocyte lineage.  Mutations in this X-chromosome-linked gene cause X-linked severe combined immunodeficiency (XSCID). (from LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23844] "IL4R when complexed with the common gamma chain (IL2RG) serves as the high-affinity interleukin 4 (IL4) receptor. It plays a major role in immunoglobulin E (IgE) production"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23845] "The IL5 Gene at 5q31.1 encodes Interleukin-5, which is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. (From LocusLink)"                                                                                                                                                                   
[23846] "The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported."                                                                                                                                                                                                                
[23847] "The IL6 Gene at 7p21 encodes Interleukin-6, which is a cytokine with a wide variety of biological functions. Interleukin-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells. It induces myeloma and plasmacytoma growth as well as nerve cells differentiation. In hepatocytes it induces acute phase reactants. (From Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23848] "Widely expressed (not restricted to IL6 responsive cells) human IL6ST Gene (Type I Cytokine Receptor 2 Family) encodes heterodimeric type I membrane protein (isoform 1) and secreted (isoform 2) Interleukin 6 Signal Transducer, containing 5 fibronectin type III domains, an Ig-like C2-type domain, a BOX 1 motif required for JAK interaction/activation, and a WSXWS motif necessary for protein folding, intracellular transport, and cell-surface receptor binding. Part of cytokine receptor complexes, IL6ST is a signal transducer dependent on receptor binding for activation by many cytokines (IL6, CNTF, LIF, IL11, CT1, and OSM) that can utilize gp130 in signal transmission. IL6ST may regulate myocyte apoptosis and have a role in embryonic development. Isoform 2 is an autoantigen in rheumatoid arthritis but it is not specific to RA. (NCI)"                                                                                                                           
[23849] "The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor common gamma chain (IL2RG). This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). (from LocusLink)"                                                                                                                                                                                                                                                                                  
[23850] "The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23851] "Interleukin-8 is a member of a family of pro-inflammatory cytokines. The best-characterized activities of IL8 include the chemoattraction and activation of neutrophils. There are two IL8 receptors, type 1 (alpha) and type 2 (beta). The type 1 IL8 receptor binds only IL8, while the type 2 IL8 receptor binds also GRO and NAP-2. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23852] "Interleukin-8 is a member of a family of pro-inflammatory cytokines. The best-characterized activities of IL8 include the chemoattraction and activation of neutrophils. There are two IL8 receptors, type 1 (alpha) and type 2 (beta). The type 1 IL8 receptor binds only IL8, while the type 2 IL8 receptor binds also GRO and NAP-2. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23853] "ILK encodes a predicted 451-amino acid protein, with an apparent molecular weight of 59 kD. The ILK protein is a serine/threonine protein kinase with 4 ankyrin-like repeats. ILK regulates integrin-mediated signal transduction. Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23854] "The protein product of the ING1 gene physically interacts with p53 and appears necessary for the role of p53 in growth inhibition/apoptosis. ING1 shares many biological functions with p53 and has been reported to mediate growth arrest, senescence, apoptosis, anchorage-dependent growth, chemosensitivity, and DNA repair. Some of these functions, such as cell cycle arrest and apoptosis, have been shown to be dependent on the activity of both ING1 and p53 proteins. (from Leuk Res 2002;26:631-5 and Exp Cell Res 2002;279:291-8)"                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23855] "This gene encodes inhibin alpha subunit that can joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. (LocusLink)"                                                                                                                                                         
[23856] "Human INHBA Gene at 7p15-p13 encodes the Inhibin Beta A subunit, heterodimerized with the Alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin negatively regulates gonadal stromal cell proliferation, has tumour-suppressor activity, and is a marker for primary as well as recurrent granulosa-cell tumors. Inhibin may be both a growth/differentiation factor and a hormone; gonadal and extragonadal expression can vary severalfold in a tissue-specific fashion. Beta A also forms a homodimer, Activin A, and joins with the Beta B subunit to form heterodimeric Activin AB; Activins stimulate FSH secretion. (NCI)"                                                                                                                                                                                                                                                                                                                                                      
[23857] "Expressed by pancreatic islet beta cells, human INS Gene (Insulin Family) encodes a 110-aa 12-kDa proinsulin precursor of secreted Insulin, a heterodimeric protein hormone derived after signal peptide removal from post-translational cleaved of proinsulin into peptide A and peptide B chains covalently linked by disulfide bonds. Binding of mature insulin to INSR stimulates glucose uptake; accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; increases cell permeability to monosaccharides, amino acids, and fatty acids; regulates protein and lipid metabolism; and decreases blood glucose concentration by moving it into cells to be used for energy. Defects in INS cause familial hyperproinsulinemia. (NCI)"                                                                                                                                                                                                                                
[23858] "Expressed in fetal perichondirum, uterus, cytotrophoblasts, and syncytiotrophoblasts, 2-exon human INSL4 Gene (Insulin Family) encodes a 139-aa 15-kDa precursor of Insulin-Like Peptide 4, containing 6 consensus half-cystine residues essential for tertiary structure. The precursor undergoes cleavage to produce A/B/C chains that form tertiary structures of all three chains, or just A and B chains. With insulin-like effects in cell growth control that are not mediated by the INSR, INSL4 may play role in trophoblast development, cell proliferation, differentiation, and bone formation. Acting through membrane tyrosine kinase receptors, INSL growth factors are essential for regulation of energy metabolism, proliferation, and differentiation; intracellular signal transduction pathways invoke a chain of phosphorylation-related events. Chorionic gonadotropin production is increased by INSL4. (NCI)"                                                              
[23859] "After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake.(LocuLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23860] "Human INSRR Gene (Insulin Receptor Family) encodes 1297-aa 144-kDa (precursor) Insulin Receptor-Related Receptor, a type I membrane protein containing 4 fibronectin type III domains, a probable tetramer of disulfide-linked alpha and beta chains, and structurally similar to INSR and IGF1R. The two alpha chains contribute to formation of the ligand-binding domain for an insulin related protein; the two beta chains carry the tyrosine kinase domain. INSRR phosphorylates insulin receptor substrates IRS-1 and IRS-2. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23861] "IRAK1 encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK1 is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23862] "Expressed in peripheral leukocytes and monocytes, human IRAK3 Gene at 12q14.1 encodes 596-aa Interleukin-1 Receptor-Associated Kinase 3, containing an N-terminal death domain and central kinase domain. IRAK3 appears to activate NF-kappa-B via IL1R. IRAK3 interacts with MYD88 and TRAF6 signaling proteins in a manner similar to the other IRAKs. It prevents dissociation of IRAK and IRAK4 from MYD88 and formation of IRAK/TRAF6 complexes. But IRAK3 does not autophosphorylate in the manner of IRAK1. IRAK1, -2, and -3 mediate the TLR2-dependent response to lipopolysaccharide. IRAK3 is induced upon TLR stimulation and negatively regulates TLR signaling. (NCI)"                                                                                                                                                                                                                                                                                                                
[23863] "IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppression. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23864] "IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23865] "The gene encodes a substrate for insulin receptor.  It acts as an interface between signaling proteins with Src homology-2 domains (SH2 proteins) and the receptors for insulin, IGF2, growth hormone, several interleukins (IL4, IL9, IL13), and other cytokines. It regulates gene expression and stimulates mitogenesis and appears to mediate insulin/IGF1-stimulated glucose transport. (from OMIM 600797)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23866] "IRS2 encodes the insulin receptor substrate 2, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS2 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS2 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin-4 receptor (IL4R) -associated kinase in response to IL4 treatment. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23867] "IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23868] "Integrins are transmembrane glycoprotein receptors that mediate cell-matrix or cell-cell adhesion, and transduce signals that regulate gene expression and cell growth. They are heterodimeric molecules consisting of noncovalently linked alpha and beta subunits. All integrin subunits display a cytoplasmic domain that interacts with the cytoskeleton, a transmembrane region, and a large extracellular domain that interacts with the extracellular matrix. The ITGB4 extracellular domain shows 35% identify with other integrin beta subunits, but is the most different among this class of molecules. The transmembrane region is poorly conserved, whereas the cytoplasmic domain showed no substantial identity in any region to the cytoplasmic tails of other integrin beta sequences or to other protein sequences. The integrin alpha-6/beta-4, a receptor for the laminins, is likely to play a pivotal role in the biology of invasive carcinoma. (from OMIM)"                 
[23869] "Induced in T-cells and natural killer cells by interleukin-2, ITK Gene (TEC Tyr Kinase Family) at 5q31-q32 encodes 620-aa 72-kDa intracellular IL2-Inducible T-Cell (tyrosine) Kinase, containing an SH2, SH3, and PH domain, which appears to localize to cell surface receptors (TCR,CD28, CD2) after stimulation and plays a role in T-cell proliferation and differentiation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23870] "Widely expressed, human ITPR1 Gene (InsP3R Family) at 3p26-p25 encodes 8 potential alternative isoforms of 2758-aa 314-kDa integral endoplasmic reticulum membrane protein Inositol 1,4,5-Triphosphate Receptor Type 1, which mediates release of intracellular calcium in response to second messenger inositol 1,4,5-trisphosphate. A likely homotetramer, the receptor contains 5 MIR domains, a large N-terminal ligand-binding cytoplasmic region, and central modulatory sites immediately upstream of the C-terminal calcium channel. Calcium appears to inhibit ligand binding to the receptor, perhaps by interaction with an inhibitory calcium-binding protein. Phosphorylation may prevent ligand-induced opening of the calcium channel. ITPR1 interacts with TRPC4 and is phosphorylated by c-AMP kinase. (NCI)"                                                                                                                                                                      
[23871] "The JAK1 gene encodes Janus kinase 1, which is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. (from LocusLink)"                                                                                                                                                                                                                                                                         
[23872] "This gene encodes a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23873] "JAK3 encodes janus kinase 3, a tyrosine kinase that belongs to the janus family. JAK3 functions in signal transduction and interacts with members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations that abrogate janus kinase 3 function cause an autosomal SCID (severe combined immunodeficiency disease). (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23874] "Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. The JTB gene (jumping translocation breakpoint) at 1q21 was identified. It is found fused with the telomeric repeats of acceptor telomeres in a case of jumping translocation. The JTB open reading frame encodes a 146-amino acid protein with a 75-amino acid extracellular domain, a 21-amino acid transmembrane domain, and a 20-amino acid intracellular domain. The JTB protein is highly conserved among divergent eukaryotic species. Northern blot analysis showed ubiquitous expression of a 1-kb mRNA, with highest expression in thyroid and skeletal muscle. Kidney and spinal cord expressed an additional transcript of approximately 1.4 kb. Jumping translocations have been reported in leukemia patients, in the Ewing family of tumors, in renal clear cell carcinoma, and in liposarcoma. (from OMIM)"                                   
[23875] "This gene encodes a receptor for VEGF or VEGF-c. It has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. (from SwissProt)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[23876] "Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23877] "Expressing a single 0.8-1.3-kb transcript, the 13-kb human KLRB1 Gene (C-Type Lectin Superfamily, NKRP1 Family) at 12p13 is the most distal gene in an NK gene complex, which contains several C-type lectin genes preferentially expressed in NK cells, including CD69, members of the NKG2 family, and CD94 (KLRD1). C-type lectin superfamily genes, including NKRP1 glycoproteins, expressed by NK cells may regulate NK cell function. Present on a subset of natural killer (NK) lymphocytes and on about 25% of peripheral blood T-cells, the type II membrane protein (external C-terminus) NKRP1A Protein contains a 158-amino acid extracellular domain with C-type lectin motifs, a 29-amino acid transmembrane domain, and a 38-amino acid cytoplasmic domain. NKRP1A protein is 46% identical to rat and mouse NKRP1, and 26% identical to human NKG2A. (from LocusLink, OMIM, and NCI)"                                                                                               
[23878] "Preferentially expressed in NK lymphocytes as 0.8-, 1.8-, 3.5-, and 5.5-kb (minor) transcripts initiated from a heterogeneous 60-bp region, 6-exon 8.3-kb human KLRD1 Gene (C-Lectin Family) at 12p13.2-p12.3 resides in an NK gene complex containing C-lectin genes CD69, NKG2 members, and KLRB1 that regulate NK cell function. Alternates CD94-A (179-amino acid, 20.5-kD) and CD94 ALT (148-amino acid) differ with exon 2 sequence. Full-length type II membrane protein (external C-terminus) CD94 Antigen contains a 147-amino acid extracellular domain with C-type lectin motifs, a 26-amino acid transmembrane domain, and a 7-amino acid cytoplasmic domain (absent in CD94 ALT). CD94 forms disulfide-bonded heterodimers with NKG2A, NKG2C, and NKG2E. Nonclassical MHC HLA-E protein ligand binds to CD94/NKG2A, CD94/NKG2B, and CD94/NKG2C NK cell receptors. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                         
[23879] "The 160-kb human KOC1 Gene at 7p11 encodes IGF-II mRNA-Binding Protein 3, which contains a KH domain. The protein binds to the 5-prime UTR of the IGF-II leader 3-prime mRNA and may repress translation of IGF-II during late development. (from LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23880] "The 73-kb human KSR Gene (SER/THR PK Family) at 17q11.1 encodes Kinase Suppressor of RAS-1, a positive modulator of RAS-MAP kinase signaling similar to RAS kinase suppressor (Drosophila). Homologs of KSR are also seen in C. elegans and mouse. The predicted 873-amino acid mouse protein contains a kinase domain similar to RAF kinases; human protein is nearly 95% similar to mouse. KSR1 is required for efficient RAS signaling. In unstimulated cells, CTAK1 constitutively associates with KSR1, phosphorylating Ser392 and conferring cytoplasmic sequestration by 14-3-3 binding. In response to growth factor, KSR1 Ser392 phosphorylation falls, allowing KSR1 to localize with activated RAS and RAF1 at the plasma membrane and facilitating phosphorylation required for activation of MEK and MAPK. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                
[23881] "Preferentially expressed in lymphoid tissues (highest in thymus), the 555-kb human LAF4 Gene (LAF4/MLLT2 Family) at 2q11.2-q12 encodes a major 8.5-kb transcript that yields Lymphoid Nuclear Protein 4, a 1227-amino acid 134-kD nuclear DNA-binding transcriptional activator that may function in lymphoid development and oncogenesis. Greatest similarity to MLLT2 occurs in the N-terminal and C-terminal regions. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23882] "Expressed in appendix, thymus, lymph node, lung, and spleen, the 41-kb human LAMP3 Gene (LAMP Family) at 3q26.3-q27 encodes a 3.2-kb transcript that produces Lysosomal-Associated Membrane Protein 3, likely involved in antigen processing by lymphoid dendritic cells that capture antigens, differentiate, and induce T-cell responses. Expression increases in mature interdigitating dendritic cells in T-cell areas. A 416-amino acid 70- to 90-kD type I integral membrane protein (larger than predicted, 44-kD), DCLAMP contains N-and O-glycosylation sites, a LAMP domain, a large extracellular domain, a transmembrane domain, and a 10-amino acid cytoplasmic domain containing a conserved GY lysosomal targeting motif. Expression is up regulated in carcinomas of esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid, and parotid tissues. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                  
[23883] "The 5.7-kb human LAMR1 Gene (Non-Integrin Family, S2P Family) at 3p21.3 contains a promoter with 4 Sp1 sites, multiple TSS, and seven exons that yield a 1.2-kb transcript encoding a conserved 295-amino acid 37-kD multifunctional protein with a negative C-terminal segment, amphipathic alpha-helices, and N-glycosylation sites. GNRH2 or GNRH1 trigger transcription. GC-rich intron 1 contains 5 Sp1 sites, intron 3 contains 2 Alu sequences, and intron 4 contains snRNA E2. Multiple retropositional pseudogenes exist; 16-21 copies per human or mouse haploid genome. Identical to 40S Ribosomal Protein SA, the encoded heterodimeric 67-kD Laminin Receptor-1 precursor is involved in translation and cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis. Gene expression in cancer cells correlates with invasive/metastatic phenotype.  (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                         
[23884] "Widely expressed in fetal and adult tissues, the 42-kb putative tumor suppressor human LATS1 Gene (SER/THR PK Family) at 6q24-q25.1 encodes conserved Large Tumor Suppressor Homolog 1, an 1130-amino acid 127-kD Ser/Thr protein kinase cell cycle regulator containing a catalytic domain and an UBA/TS-N domain. The C-terminal kinase domain of human and mouse proteins share 99% identity; human and Drosophila share 74% identity. The kinase domain and N-terminal region interact, suggesting intramolecular regulation. Phosphorylated in a cell cycle-dependent manner (late prophase-metaphase), LATS1 is a negative regulator of CDC2/cyclin A. In early mitosis, it complexes (via the N-terminal region) with the mitotic apparatus cell cycle controller CDC2 kinase; the complex shows reduced H1 histone kinase activity. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                            
[23885] "The 87-kb human LATS2 Gene (SER/THR PK Family) at 13q11-q12 encodes a 5.8-kb transcript that yields a 125-kD nuclear Large Tumor Suppressor Homolog 2 protein, expressed in many tissues; highest expression in heart and skeletal muscle. Testis also expresses a 3.8-kb transcript, which may have a shorter 3-prime untranslated region than the 5.8-kb transcript. A Ser/Thr protein kinase, LATS2 protein contains seven PAPA repeats (dipeptide proline-alanines) that may be involved in protein-protein interactions and a C-terminal kinase domain. Human and mouse proteins are most closely related to LATS1 proteins, followed by Drosophila Lats. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                         
[23886] "The 50-kb human LCP2 Gene at 5q33.1-qter is expressed in peripheral leukocytes, spleen, thymus, T-cells, B-cells, and monocytes as a modular 533-amino acid 76-kD Lymphocyte Cytosolic Protein 2 with three domains; a PEST domain and phosphorylatable tyrosine residues in the acidic N-terminus, a GRB2 binding site in the central proline-rich domain, and a C-terminal SH2 domain. As an adaptor/scaffold protein, SLP-76 associates constitutively or inducibly with GRB2 and FYB adapter proteins and with ZAP70 and SYK as a substrate. By supporting receptor-mediated signal transduction, SLP-76 promotes thymic development and T-cell development and activation, as well as mast cell and platelet function. SLP-76 may collect all pre-TCR signals that drive thymocyte development and appears required for separate development of lymphatic vessels from blood vessels. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                             
[23887] "Closely linked to a related pseudogene, the 2.9-kb human LEFTB Gene (TGF-Beta Family) at 1q42.1 is separated by approximately 50-kb from the related LEFTYA gene. Both genes comprise four exons spliced at identical positions and encode strongly similar secreted proteins. Containing a TGF-beta family domain, 366-amino acid 41-kD Left-Right Determination Factor B (preproprotein) undergoes cell-specific alternative processing into three different products. Processing may occur at R-X-X-R sites. LEFTB appears required for left-right determination during early presomite development in mammals. It may serve as a feedback inhibitor to restrict the range of nodal signaling during establishment of the axis. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                     
[23888] "Distal to D1S515 (3-4 cM), centromerically transcribed 193-kb human LEPR Gene (gp130 Cytokine Receptor Family) at 1p31 contains 2 intronic microsatellites and 18 coding exons spliced into 5 Leptin Receptor isoforms variously expressed in liver, hypothalamus, heart, small intestine, hematopoietic tissues, choroid plexus, prostate, ovary, lung and kidney. Isoform E may be soluble. Rat and mouse genes express multiple isoforms. The 1165-amino acid 132.5-kD (precursor) type I membrane protein contains 3 fibronectin III-like domains and is TYR phosphorylated; the cytoplasmic domain appears essential for signal transduction. LEPR appears involved in regulation of fat metabolism through hypothalamic effects, angiogenesis, lymphopoiesis, and possibly reproduction. LEPR appears to activate JAK kinase and STAT3, -5, and -6. LEPR malfunction is associated with diabetes and obesity. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                    
[23889] "With the exception of peripheral blood lymphocytes, the 9-kb human LGALS3BP Gene (MSR1 Superfamily) at 17q25 appears to be expressed at high levels in all tissues as a 2.2-kb transcript (highest in gastrointestinal tissues). The 585-amino acid extracellular Galectin 3 Binding Protein contains an N-terminal macrophage scavenger receptor (MSR1) Cys-rich domain and binds LGALS3 via a carbohydrate-specific interaction. MAC2BP is a potent stimulator of host immune defense systems, such as NK and LAK cell cytotoxicity, and can induce IL2 cytokine production. Oncogenic transformation, viral infection, or pathogen invasion enhance MAC2BP production. LGALS3BP is elevated in the serum of cancer and HIV patients. (from LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                            
[23890] "Constitutively and ubiquitously expressed, 32.6-kb human LGALS8 Gene (S-Lectin Family) at 1q42-q43 contains a TATA box and eight primary exons. With two alternate exons present in splice variants, three isoforms of 1.6-, 2.6-, and 6-kb are produced. Similar to rat Galectin-8 and containing two carbohydrate-binding (recognition) domains (CRDs), 316-amino acid 35.5-kD extracellular Galectin 8 binds to beta galactoside in cell adhesion, cell cycle regulation, inflammation, immunomodulation, apoptosis, and metastasis. Galectin 8 may be involved in activation of various cell types through cross-linkage of cell surface glycoproteins and may be involved in some types of cancer. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                
[23891] "Predominantly expressed in neural tissues, putative tumor suppressor 40.3-kb human LGI1 Gene at 10q24 encodes a predicted 557-amino acid, 64-kD precursor Leucine-Rich Glioma-Inactivated Protein. Alternative splicing of exon 8 appears to vary between brain and skeletal muscle. Mature 60-kD LGI1 protein contains putative extracellular N-terminus and hydrophobic transmembrane segment, as well as leucine-rich repeats (LRR) with conserved cysteine-rich flanking sequences. LGI1 shows high similarity in the LRR domain with transmembrane and extracellular receptors and adhesion proteins. Translocation rearrangements of LGI1 reduce or abrogate expression in several glioblastomas and brain tumors. LGI1 mutations appear responsible for autosomal dominant partial epilepsy with auditory features. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                             
[23892] "Organized like other LHX genes, with five exons (separated by 0.93-2.3-kb introns) and expressed in brain, thymus, and tonsil, the conserved 5.7-kb human LHX1 Gene (LIM/Homeobox Family) at 11p13-p12 encodes 384-404-amino acid 44.5-kD nuclear LIM Homeobox Protein 1, a putative transcriptional regulatory protein containing two CYS-rich zinc ion-binding LIM domains and a DNA-binding homeobox domain. The LIM domains reside in exons 1 and 2, while the homeodomain is split among exons 3 and 4. An intron at the same position occurs in other homeobox genes, suggesting an ancestral intron insertion. LIM1 may regulate the head organizer and control differentiation and development of neural and lymphoid cells. LIM1 and LMX1B appear to control lateral column motor axon dorsal/ventral trajectory in the developing limb. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                      
[23893] "Centromeric to ABL and closely related to 'apterous' (Drosophila), the 21.5-kb human LHX2 Gene (LIM/Homeobox Family) at 9q33-q34.1 encodes 406-amino acid 44-kD nuclear LIM Homeobox Protein 2, a putative transcription factor containing two CYS-rich zinc ion-binding LIM domains and a DNA-binding homeobox domain. LIM2 may control differentiation and development of neural and lymphoid cells. Rodent LH2 is expressed in the central nervous system and in immature B- and T-cells. In the pituitary, mouse Lh2 regulates expression of the pituitary glycoprotein hormone alpha subunit. High expression is observed in chronic myelogenous leukemia (CML). (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                  
[23894] "Leukemia inhibitory factor is a cytokine that induces macrophage differentiation. Neurotransmitters and neuropeptides, well known for their role in the communication between neurons, are also capable of activating monocytes and macrophages and inducing chemotaxis in immune cells. LIF signals through different receptors and transcription factors. LIF in conjunction with BMP2 acts in synergy on primary fetal neural progenitor cells to induce astrocytes. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23895] "The LIF gene encodes Leukemia Inhibitory Factor (LIF), which is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action is mediated through a high-affinity receptor complex composed of Leukemia Inhibitory Factor Receptor (a low-affinity LIF binding chain) and gp130 (a high-affinity converter subunit). The high-affinity complex also binds oncostatin M, a related cytokine. Both Leukemia Inhibitory Factor Receptor and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. (from OMIM)"                                                                                                                                                                                  
[23896] "The LIMD1 gene encodes LIM Domains Containing 1. LIM domains consist of a cysteine-rich consensus sequence containing two distinct zinc-binding subdomains, which mediate protein-protein interactions. The predicted protein sequence of this gene reveals three LIM domains located at the C-terminal end, which indicates that it belongs to the group 3 of the gene family encoding LIM motifs. This gene is ubiquitously expressed at the mRNA level. The LIM motif has been previously identified in many developmentally important factors from various eukaryotes. These factors have been shown to play a role in intracellular signaling, transcriptional regulation and cellular differentiation during development. The LIMD1 gene may have a role in tumor suppression. (from PubMed)"                                                                                                                                                                                                 
[23897] "LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Two splice variant have been identified. (LocusLink)"                                                                                                                                                                                                                                                                                                                                       
[23898] "The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                             
[23899] "The CEB1 gene encodes Cyclin-E Binding Protein 1, which cyclin E, as well as other cyclins tested, specifically interacts with even in the absence of p21. CDK inhibitors, however, including p21 and p27, show either weak or no interaction with CEB1. The expression of CEB1 appears to be regulated by RB and p53. CEB1 may regulate or mediate the activity of CDKs because CEB1 is highly induced when both RB and p53 are inactivated, with subsequent elevation of CDK activity. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23900] "The Link-GEFII gene encodes Link Guanine Nucleotide Exchange Factor II, which is a Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. This protein is a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. (from LocusLink and PubMed)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23901] "The LOH11CR2A gene encodes BCSC-1, a predicted 438-amino acid protein. The LOH11CR2A coding region is composed of 10 exons and spans 30 to 40 kb. There are at least 2 additional exons encoding the 5-prime untranslated region. LOH11CR2A is expressed ubiquitously as a 3.3-kb mRNA. BCSC-1 is a putative tumor suppressor, but unlikely to be involved in the tumorigenic process. (from LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23902] "The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23903] "The LTB4R gene encodes Leukotriene B4 Receptor, which belongs to family 1 of G-protein coupled receptors. This protein is a receptor for extracellular ATP, UTP and ADP, and its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. This protein may be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. It is also a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immumne response. It is expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver, with high level of expression in lymphoid tissues. (from Swiss-Prot)"                                                                                                                                                                                                                                                         
[23904] "LTBP2 encodes a latent transforming growth factor-beta (TGF-beta) binding protein. LTBP2 binding of TGF-beta in the extracellular-matrix serves as an important mechanism to regulate TGF-beta function. Mutations in LTBP2 have been identified in two instances of atypical Marfan syndrome. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23905] "The LTK gene encodes Leukocyte Tyrosine Kinase. A set of cDNAs represents differently spliced human LTK mRNAs. These cDNAs predict a truncated receptor protein lacking the tyrosine kinase domain and a soluble receptor protein that has neither a transmembrane nor a tyrosine kinase domain. The LTK gene produces not only the putative receptor tyrosine kinase for unknown ligand but also multiple protein products that may have different functions. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23906] "LY6E gene is 4.0 kb long and consists of 4 exons and 3 introns. The deduced amino acid sequence predicts a cell surface protein containing 20 amino acids at the N-terminal end corresponding to a signal peptide and an extracellular sequence containing 111 amino acids. LY6E encoded protein shares some homology with CD59 and with a number of growth factor receptors. It shares high sequence homology with the murine LY6 multigene family, whose members are small cysteine-rich proteins differentially expressed in several hematopoietic cell lines and with apparent function in signal transduction. RIGE is the closest human homolog of the LY6 family. The expression of RIGE is not restricted to myeloid differentiation, because it is also present in thymocytes and in a number of other tissues at different levels. By Northern blot analysis, the highest expression of RIGE was found in liver, kidney, and ovary in addition to peripheral blood leukocytes. (OMIM)"    
[23907] "The human LYL1 gene encodes Lymphoblastic Leukemia Derived Sequence 1, which contains 1 basic helix-loop-helix (bHLH) domain. Efficient DNA binding of this protein requires dimerization with another bHLH protein. This gene is involved in a form of T-cell acute lymphoblastic leukemia (T-ALL) through a chromosomal translocation t(7;9)(q35;p13) which involves LYL1 and T-cell receptor beta chain (TCRB) genes. (from Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23908] "Composed of 0.73-1.23-kb exons and 0.17-5.3-kb introns, 61-kb human MADD Gene at 11p11.2 is expressed in adult testis, ovary, brain, heart, and fetal brain and kidney. Eight transcript variants (encoding isoforms A-G) involve variable use of exons 1, 13, 16, 21, 26, and 34. Variant 4 encodes full-length 1588-amino acid 176.6-kD MADD Protein isoform D. Most isoform variations involve 2-4 stretches of 18-43-aa in the central region. Isoforms F and G have a different C-terminus. Containing a C-terminal death domain, RGD motif, and a leucine zipper-like motif, SER- and LEU-rich membrane-bound MADD adaptor protein interacts with TNFR1 death domain to propagate apoptotic signaling. MADD can activate ERK2 and JNK1 MAP kinases and induce phosphorylation of Phospholipase A2. MADD appears to link TNFR1 with MAP kinase activation and arachidonic acid release. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                           
[23909] "Ubiquitously transcribed from CpG promoters and 3-Mb proximal to SMAD4, 12-exon 90-kb human MADH2 Gene (SMAD Family) at 18q21.1 expresses 2.9- and 3.4-kb transcripts encoding 438/467-aa 52-kD SMAD2 containing a DWA/MH1 and DWB/MH2 domain. SMADs mediate Activin, TGFB, and BMP receptor Ser/Thr kinase cell growth/differentiation regulation. Retained by cytoplasmic SARA, SMAD2/SMAD3 are phosphorylated on conserved C-terminal MH2 docking SER-X-SERs by activated receptor. SMAD2/SMAD3 oligomerize with nuclear SMAD4, disrupting SNON/SMAD4 repressors. SMAD3 causes SNON degradation. SMAD2/SMAD4 activate target promoters. TGFBR activity maintains nuclear SMADs and increases feedback SNON expression. SMAD2 interacts with FAST-1/-2, TGIF, PEBP2-A, CBP, p300, c-SKI, NUP214, NUP153, and SMURF2. MADR2 mutations may disrupt growth inhibition. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                  
[23910] "The 79.7-kb human MADH6 Gene (SMAD Family) at 15q21-q22 is ubiquitously expressed (predominantly in vascular endothelium) as alternative SMAD6 Protein isoform A (496-aa 53.5-kD) and isoform B (235-aa), similar to other MAD-related proteins acting as second messengers distal to TGFBRs and containing an N-terminal DWA/MH1 domain and a C-terminal DWB/MH2 domain. An inhibitory SMAD phosphorylated by type 1 receptor kinase, SMAD6 acts as an antagonist of TGF-beta type 1 receptor signaling. A selective inhibitor of BMPs signaling; SMAD6 competes with SMAD4 for receptor-activated SMAD1. SMAD6 interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8, and HOXC9. MADH6 and MADH7 form complexes. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                 
[23911] "Induced by TGF-beta and IFNG, ubiquitously expressed (lung and vascular endothelium highest) 31-kb human MADH7 Gene (SMAD Family) at 18q21.1 encodes 426-amino acid SMAD7 Protein, an Activin/TGFBR1 signaling inhibitory component containing DWA/MH1 and DWB/MH2 domains and lacking the C-terminal phosphorylation sites of other MAD proteins, suggesting distinct regulation. Adaptor SMAD7 constitutively recruits nuclear E3 ubiquitin ligase SMURF2 to TGFBR complexes preventing SMAD2 access and causing proteasomal and lysosomal receptor degradation. SMAD7-expressing cells are susceptible to apoptosis induced by TGFB, TNFA, serum withdrawal, or loss of cell adhesion. SMAD7 decreases NFKB activity, promoting apoptosis. RAS suppresses SMAD7 inhibition of NFKB and potentiation of apoptosis. MADH7 and MADH6 form complexes. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                   
[23912] "The 204-kb human MADHIP Gene at 1p32.3 expresses ubiquitous alternate transcripts: full-length isoform 1 (1425-aa, 156 kD), variant 2 (1210-aa), variant 3 (762-aa). 3-Prime abbreviated, variant 2 encodes a truncated protein. Translation initiates downstream in variant 3; the 5-prime UTR and 3-prime region differ. Cytoplasmic SARA Protein contains a FYVE domain zinc finger, seen in signaling molecules and required for SARA localization but not SMAD interaction. Able to bind PI-3 phosphate, SARA recruits SMAD2/3 to TGFBR. The SMAD binding domain (SBD) of SARA interacts with the SMAD2/3 MH2 domain; the C-terminal domain interacts with TGFBR. SMAD2/SMAD3 phosphorylation induces SARA dissociation, SMAD2/SMAD4 formation, and SMAD nuclear translocation. Disruption of MADHIP appears to be involved in Alzheimer's disease. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                               
[23913] "The 99.5-kb human MAGED1 Gene (MAGE Family) at Xp11.23 seems to express a ubiquitous 778-amino acid 86-kD cytoplasmic NRAGE Protein that contains a 200-amino acid MAGE homology domain. NRAGE appears to shift from cytoplasm to plasma membrane upon NGF stimulation to interact with p75NTR. NRAGE antagonizes p75NTR association with TRKA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. NRAGE may regulate the function of DLX family members. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23914] "Activated by UV and osmotic shock, the 128.6-kb human MAP2K6 Gene (MAP2K Family) at 17q24.3 expresses a 1.7-kb transcript in skeletal muscle that encodes 278-aa MKK6. Longer at the N-terminus, MKK6B (334-aa, 37.5-kD) is encoded by 1.8-, 2.4-, and 4.5-kb transcripts enriched in heart, skeletal muscle, pancreas, and liver. Tissue-specific splicing may control of MKK6 expression. MKK6 is about 80% identical to MKK3 and 40% identical to MKK4. Probably activated by Ser/Thr phosphorylation, MKK6 Thr/Tyr phosphorylates p38-MAPK exclusively in response to inflammatory cytokines or environmental stress, inducing cell cycle arrest, transcription activation, and apoptosis. Calcium influx triggers the MKK6/p38-MAPK cascade; p38-MAPK activates MEF2s that regulate expression of genes critical for cell survival. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                               
[23915] "The 78-kb human MAP3K1 Gene (MAP3K Family) at 5q11.2 encodes a Ser/Thr MEKK1 Protein pivotal in the phosphorylation network that integrates cellular responses to mitogenic and metabolic stimuli. IFNG induces MEKK1 expression. An efficient activator of the JNK cascade, MEKK1 can phosphorylate MEK1/MEK2, which activate MAPKs. The PHD domain of MEKK1, a RING-type zinc finger, exhibits E3 ubiquitin ligase activity toward ERK2. Thus, MEKK1 functions as both an upstream activator of ERK and JNK through its kinase domain and as an E3 ligase through its PHD domain, decreasing ERK1/ERK2 activity. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                     
[23916] "Expressed as a single 5-kb transcript from 15 exons in small intestine, spleen, thymus, peripheral leukocytes, testis, prostate, ovary, and colon, the 27.8-kb human MAP3K14 Gene (MAP3K Family) at 17q21 encodes autophosphorylated 947-amino acid 104-kD cytoplasmic Ser/Thr Protein Kinase NIK, involved in NFKB activation. NIK selectively activates NFKB cascades of TNF/NGF receptors and IL1R type-I. TNFA acts through TRAF2; IL1 acts through IRAK1 and TRAF6. LTBR and CD95 also act through NIK. NIK appears to bind TRAFs 2, 5, and 6, IKKA, and NFKB2/p100. Binding to TRAF2 involves the TRAF2 N- and C-terminal regions. NIK induces NFKB2/p100 processing, degradation of phosphoserine-induced ubiquitinated destruction of IKBA, and release of cytoplasmic NFKB for nuclear translocation and kappa-B DNA-mediated gene expression.  (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                               
[23917] "With a TATA-less and CpG island promoter, 71.6-kb 17-exon human MAP3K7 Gene (MAP3K Family) at 6q16.1-q16.3 generates ubiquitous 3.2 to 5.7-kb variants involving exons 12 and 16 that encode TAK1 Protein isoforms A, B (606-aa, 67.2-kD), C, and D. A, C, and D lack 1-2 coding segments compared to B. C and D frameshifts yield shorter C-termini (may affect TAB2 interaction). Human and mouse TAK1 are 99% identical. The TAK1 N-terminus interacts with TAB1 and contains ATP-binding and kinase domains. Regulating transcription and apoptosis, TAK1 mediates TGFB/BMP, IL-1, and stress signaling. With TAB1 and TAB2, TRIKA2-mediated (TRAF6/TRIKA1) ubiquitinated TAK1 phosphorylates IKKB, MAP2K3, MAP2K4, and MAP2K6, which stimulate JNK1 and SAPK2. TAK1 induces NIK-independent IKBA and IKBB degradation and NFKB p50/p65 nuclear translocation. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                     
[23918] "The 37-kb human MAP3K7IP1 Gene at 22q13.1 generates a ubiquitous 3.5-kb mRNA that encodes 504-amino acid 54.6-kD TAK1-Binding Protein 1, a MAP3K responsible for mediation of TGF-beta receptors and activation of TAK1 kinase. The 68 C-terminal amino acids are sufficient for binding and activation of TAK1 kinase activity. The N-terminal 418 amino acids inhibit TGFB-induced gene expression. TAB1 contains a PP2C domain and amino acids 373-418 are required for phosphorylation of p38-alpha. Formation of TRAF6/TAB1/p38-alpha complexes are enhanced by lipopolysaccharide. TAB1 also interacts with BIRC7. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                               
[23919] "The ubiquitously expressed 195-kb human MAP4K4 Gene (SER/THR Family, STE20 Subfamily) at 2q11.2-q12 generates 5 tissue alternative isoforms of HGK Protein; variant 2 is longest and contains proline-rich domains. Compared to variant 2, variants 1 and 3 lack two coding segments; variant 1 contains an extra coding segment. HGK contains a CNH domain and an N-terminal catalytic domain with 11 kinase subdomains; it shares 47-48% amino acid identity with HPK1 and GCK catalytic domains. In response to environmental stress and cytokines such as TNFA, HGK appears to act through MAP3K7, MAP2K4, and MAP2K7 cascades to activate JNK and the c-JUN N-terminal transcriptional pathway. HGK may interact with the SH3 domain of NCK adapter proteins. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                     
[23920] "The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants. (LocusLink)"                                                                                    
[23921] "MAPK11 Gene encodes MAP Kinase 11, a member of the MAP kinase family of integration points for multiple biochemical signals and involved in a variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK11 is most closely related to p38 MAP kinase; both can be activated by proinflammatory cytokines and environment stress. MAPK11 is activated through phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of MAPK11. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                         
[23922] "Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. SAPK3 functions as a signal transducer during differentiation of myoblasts to myotubes. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23923] "The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                     
[23924] "Expressed in brain, heart, placenta, pancreas, skeletal muscle, lung, liver, and kidney, 83-kb alternatively spliced human MAPK14 Gene (MAPK Family) at 6p21.3-p21.2 encodes four isoforms (varying by internal segments and C-termini) of (Ser/Thr) Mitogen-Activated Protein Kinase 14, involved in oxidative/hypoxic/environmental/genotoxic stress, transcription, cell cycle regulation, and apoptosis. Bound to cytoplasmic PTPRR and activated by cell stress, proinflammatory cytokines, LPS, Thr/Tyr phosphorylation by MAP2K3, MAP2K6, and MAP2K4, and autophosphorylation by MAP3K7IP1/TAB1 interaction, p38 MAPK phosphorylates MAPKAPK2, MAPKAPK5, ELK-1, ATF2, MEF2C, MAX, CDC25B, and p53. p38 is inhibited by DUSP1 and CSAID drugs. (NCI)"                                                                                                                                                                                                                                         
[23925] "Highly expressed in heart and brain, human MAPK4 Gene (MAPK Family) encodes 557-aa 63-kDa MAP Kinase 4, a Ser/Thr protein kinase activated by tyrosine kinase growth factor receptors that translocates to the nucleus to phosphorylate nuclear targets and likely promote entry in the cell cycle. MAPK4 also phosphorylates MAP2. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23926] "Expressed in skeletal muscle, brain, heart, placenta, lung, liver, pancreas, kidney, and fibroblasts, human MAPK6 Gene (MAPK Family) encodes 721-aa 83-kDa nuclear MAP Kinase 6, a Ser/Thr protein kinase activated by protein phosphorylation cascades that acts as an integration point for multiple biochemical signals and likely promotes entry in the cell cycle. MAPK6 phosphorylates MAP2. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[23927] "Highly expressed as four alternative transcripts in heart, placenta, lung, kidney, and skeletal muscle, human MAPK7 Gene (MAPK Family) encodes 815-aa 88.6-kDa MAP Kinase 7, a Ser/Thr kinase specifically activated by MAP2K5 (not MEK1/MEK2) and involved as an integration point for multiple downstream signals of various receptors, including receptor type kinases and GPCRs, in cell proliferation, differentiation, transcription regulation, and development. Autophosphorylated and likely activated by tyrosine and threonine phosphorylation by upstream kinase, MAPK7 translocates to the nucleus in response to extracelluar signals and regulates gene expression by phosphorylating and activating target transcription factors. The C-terminus may have an autoregulatory role, and the second Pro-rich region may interact with actin, targeting MAPK7 to specific cell locations. (NCI)"                                                                                        
[23928] "Expressed as alpha-1, -2, beta-1, -2 isoforms, human MAPK9 Gene (MAPK Family) encodes MAP Kinase 9, a stress/cytokine-induced Ser/Thr kinase that acts as an integration point for multiple biochemical signals involved in target transcription factor regulation, such as c-Jun and ATF2. Alpha-1, and 2 bind c-Jun; beta-1 and 2 bind ATF2. JunB and JunD are not substrates for alpha-2. Inhibited by dual specificity phosphatases, and phosphothreonine/tyrosine activated by a Ras-dependent dual specificity MAP2K4/MAP2K7 cascade, MAPK9 mediates immediate-early gene expression. MAPK9 binds scaffolding proteins MAPK8IP1/2/3. MAPK9/UV-induced apoptosis appears related to cytochrome c-mediated cell death. Increased p53 stability in nonstressed cells results from MAPK9 blocked p53 ubiquitination. MAPK9 appears required for T-helper cell differentiation into Th1 cells. (NCI)"                                                                                              
[23929] "Human MAPRE1 Gene (MAPRE/RP/EB Family) encodes 268-aa 30-kDa Microtubule-Associated Protein RP/EB Family Member 1, containing a CH domain and a C-terminal domain that binds to APC. In interphase, MAPRE1 localizes to microtubules (growing ends); during mitosis, MAPRE1 is associated with centrosomes and spindle microtubules. MAPRE1 also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. MAPRE1 also interacts with TERF1. MAPRE1 is likely involved in regulation of microtubule structures, microtubule polymerization, spindle function, and chromosome stability. (NCI)"                                                                                                                                                                                                                                                                                                                                                           
[23930] "This gene encodes a protein that has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. There are three alternatively spliced transcript variants described for this gene encoding different isoforms. (LocusLink)"                                                                                                                                                                                        
[23931] "Human MCT-1 Gene encodes MCT-1 Protein, of unknown function. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23932] "This gene encodes neurite outgrowth-promoting factor 2, a 143-residue protein which is a precursor for a mature protein of 121 amino acids and is 46% homologous with another heparin-binding neurite outgrowth-promoting factor, NEGF1. NEGF2 is also known as midkine. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines.(from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23933] "Expressed in immunohepatopoietic tissues and in brain, human MEIS1 Gene (TALE/MEIS Family) encodes 390-aa 43-kDa Homeobox Protein MEIS1, containing one homeobox domain, the only conserved motif in the entire protein. Homeobox genes play a crucial role in normal development. Mouse Meis1 regulates Pbx1 protein activity by promoting nuclear import and specifies cell fates and differentiation patterns along the proximodistal limb axis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23934] "Expressed in monocytes, bone marrow, and tissues of epithelial and reproductive origin, human MERTK Gene (AXL/UFO Family) encodes 999-aa 110-kDa (precursor) Receptor Tyrosine Kinase MERTK, containing 2 extracellular N-terminal Ig-like C2-type domains and 2 membrane proximal fibronectin type III domains, a putative transmembrane segment, a tyrosine kinase KWIAIES domain, several N-glycosylation sites, and tyrosine phosphorylation sites. Not expressed in normal B- and T-lymphocytes, MERTK is expressed in numerous neoplastic B-and T-cell lines. MERTK defects cause retinitis pigmentosa. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                
[23935] "Expressed by mammary epithelia and activated macrophages, human MFGE8 Gene encodes 387-aa 43-kDa (precursor) Milk Fat Globule-EGF Factor 8 Protein, a multidomain cell surface (and secreted) protein that contains an EGF-like domain, C-terminal F5/8 type C domains, and the cell adhesion tripeptide RGD. MFGE8 recognizes aminophospholipids (phosphatidylserine) and binds to cells via its RGD motif; MFGE8 binds strongly to cells expressing alpha-V-beta-3 integrin. Expressed by activated macrophages, MFGE8 specifically binds to apoptotic cells and appears to promote macrophage phagocytosis of apoptotic cells. MFGE8 is overexpressed in several carcinomas. (NCI)"                                                                                                                                                                                                                                                                                                              
[23936] "Ubiquitously expressed as a 6.6-kb transcript, human MFHAS1 Gene encodes 1,052-aa 117-kDa MASL1 Protein, containing an ATP/GTP-binding site, 3 leucine zipper regions, and a leucine-rich tandem repeat (often elements of interaction among proteins related to the cell cycle). MASL1 shares 36% sequence homology with IGFALS. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23937] "This gene is a member of the fringe gene family which also includes Radical and Lunatic fringe. They all encode evolutionarily conserved secreted proteins that participate in the Notch signaling pathway in determining boundaries during segmentation and cell fates during neurogenesis. (from LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23938] "Upregulated by vitamin D in bone cells and expressed at high levels in heart, kidney, and lung, 3.9-kb 4-exon human MGP Gene (Osteocalcin/MGP Family) encodes 103-aa 12-kDa (precursor) secreted Matrix Gla Protein, associated with the organic matrix of bone and cartilage and a putative inhibitor of bone formation. Like all known vertebrate vitamin K-dependent proteins, MGP contains a transmembrane signal peptide, a putative gamma-carboxylase recognition site, and a Gla-containing domain. MGP requires vitamin K-dependent gamma-carboxylation for its function. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                            
[23939] "This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. (Locuslink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23940] "Induced by INF gamma and oriented head-to-tail and separated by less than 16-kb with INP10, human CXCL9 Gene (Intercrine Alpha/Chemokine CXC Family) at 4q21 encodes secreted 125-aa 14-kD (precursor) chemoattractant (T-cells) Small Inducible Cytokine B9 that binds to CXCR3 and is involved in angiogenesis and T-cell activation in inflammatory responses. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23941] "Widely expressed (3-kb mRNA), human MKNK1 Gene (Ser/Thr Kinase Family) encodes alternative 465-aa (51-kDa) and 424-aa MAP Kinase Interacting Kinase 1 isoforms, containing a typical Ser/Thr kinase domain, an N-terminal putative NLS, and sharing homology with MAPKAPK2, MAPKAPK3, and p90(RSK). Strongly interacting with, and phosphorylated/activated (via C-terminal region) by, dephosphorylated p38MAP and ERK kinases, but not JNK/SAPK, MKNK1 is activated by many extracellular mitogenic and stress stimuli. Docking with EIF4G1 and -2 C-terminal regions, MNK1 appears to regulate transcription by phosphorylating EIF4E and increasing affinity for the 7-methylG mRNA cap. MNK1 also interacts with the translational inhibitor p97 C-terminus. p97 may sequester MNK1, blocking eIF4E phosphorylation. (NCI)"                                                                                                                                                                    
[23942] "Human MKPX Gene encodes 184-aa 21-kDa Dual Specificity Phosphatase 22. While MAP kinases play a pivotal role in cellular signal transduction, dual-specificity phosphatases can reverse MAP kinase activation by dephosphorylating critical phosphotyrosine and phosphothreonine residues. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23943] "Expressed (18-kb mRNA) in most adult tissues, including hematopoietic cells, except liver, human MLL2 Gene (TRX Family) encodes alternative 5262-aa (564-Da) and 4957-aa isoforms of Myeloid/Lymphoid or Mixed-Lineage Leukemia Protein 2, a putative nuclear transcription factor of the ASCOM complex likely to play a similar role to ALL1 and TRX, although the target genes have yet to be identified. The 5262-aa isoform contains 5 PHD-type zinc fingers, 1 post-SET domain, 1 RING-type zinc finger, and 1 SET domain; the 4957-aa isoform lacks an N-terminal zinc finger and a PHD finger. MLL2 contains 24 amino acid runs, all but 2 of which are Glu runs; proteins with similar features play roles in transcription, translation, and developmental regulation. (NCI)"                                                                                                                                                                                                              
[23944] "Human MLLT1 Gene encodes 559-aa 62-kDa nuclear ENL Protein, a protein similar to MLLT3/AF9 (Human), TFG3/ANC1 (Yeast), and trithorax (Drosophila) that contains nuclear targeting sequences, serine- and proline-rich regions, and stretches abundant in basic amino acids and appears capable of transcriptional transactivation in lymphoid and myeloid cells. The C-terminal 90-aa of MLLT1 are required for activation of transcription. A common acute leukemia chromosomal translocation t(11;19)(q23;p13.3) involves MLL/HRX and MLLT1 that results in a rogue chimeric activator protein containing the MLL N-terminal AT-hook motifs. (NCI)"                                                                                                                                                                                                                                                                                                                                               
[23945] "Widely expressed as a single transcript of nearly 10-kb, human MLLT2 Gene (AF4 Family) encodes 1210-aa 131-kDa AF-4 Protein, a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus and high sequence homology with ENL protein. A common acute leukemia chromosomal translocation t(4;11)(q21;q23) involves a fusion of MLLT2 and MLL/HRX that form reciprocal products coding for chimeric rogue proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23946] "Human MLLT3 Gene, more than 100-kb, encodes 568-aa 63-kDa AF-9 Protein, putative transcription factor similar to TFG3/ANC1 (Yeast) and containing similar functional domains as MLLT1 and MLLT2 (Human), including nuclear targeting sequences, serine-rich and proline-rich regions, and stretches abundant in basic amino acids. BCR1 is located within intron 4; BCR2 spans introns 7 and 8. A common acute leukemia chromosomal translocation t(9;11)(p22;q23) involves a fusion of MLLT3 and MLL/HRX that produces a chimeric rogue activator protein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23947] "Expressed in a variety of cell types, human MLLT4 Gene encodes 1816-aa 206-kDa AF-6 Protein, a possible signal transduction protein controlled by Ras signaling pathways that is strongly similar to afadin (rat) and contains short stretches rich in proline, charged amino acids, serines, or glutamines, 1 dilute domain, 1 FHA domain, 1 PDZ/DHR domain, and 2 RAS-associating domains. Shared with several vertebrate and invertebrate proteins, the MLLT4 GLGF motif may be involved in signal transduction at special cell-cell junctions. MLLT4 binds directly to ZO-1 and occludin. MLLT4 may bind to actin filaments, linking the actin cytoskeleton to the plasma membrane at cell-to-cell adherens junctions. A common acute leukemia chromosomal translocation t(6;11)(q27;q23) involves fusion of MLLT4 and MLL/HRX that results in production of a rogue activator protein. (NCI)"                                                                                                  
[23948] "Human MLLT6 Gene encodes 1093-aa 112-kDa AF-17 Protein, high similarity to AF10 and containing amino acid stretches associated with transcriptional repression or activation: a 3-prime leucine-zipper dimerization motif and a terminal cysteine-rich domain of 3 zinc fingers (2 PHD-type) similar to a domain in Br140 protein. A common acute leukemia chromosomal translocation t(11;17)(q23;q21) involves fusion of MLL/HRX and MLLT6 that produces a rogue activator protein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23949] "Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas, 3-exon human MLLT7 Gene (Forkhead Family) encodes 505-aa 54-kDa Forkhead Box Protein O4, highly similar to forkhead transcription factor FKHR protein within its single forkhead domain and containing serine- and proline-rich regions like ENL protein. AFX-like proteins appear involved in cell cycle regulation. MLLT7 appears to block cell cycle progression at G1, independent of Rb but dependent on p27(KIP1). MLLT7 transcriptionally activates p27(KIP1). MLLT7 may also play a role in the insulin signaling pathway. Acute leukemia chromosomal translocation t(X;11)(q13;q23) involves MLLT7 fused to MLL/HRX that encodes a chimeric rogue activator protein. (NCI)"                                                                                                                                                                                                                       
[23950] "Expressed in a variety of tissues, but abundant in the kidney proximal tubule brush border and glomerular epithelium, 24-exon 80-kb single copy human MME Gene (M13 Peptidase Family) encodes (initiation in exon 3) 749-aa 100-kDa Membrane Metalloendopeptidase, a zinc-binding type II transmembrane glycoprotein that preferentially cleaves Gly-Phe bonds of peptides at the N side of hydrophobic residues and inactivates several peptide hormones, including insulin, glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin, as well as casein, hemoglobin, and other proteins and polypeptides. An important cell surface marker of human acute lymphocytic leukemia, MME is present on pre-B leukemic cells, which represent 85% of cases of ALL. (NCI)"                                                                                                                                                                                                              
[23951] "Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. (LocusLink)"                                                                                                                                                                                                                                                                                                  
[23952] "Expressed (2-kb mRNA) in a variety of tissues (abundantly in erythroid stem cells to differentiated reticulocytes), single copy 12-exon 28-kb human MPP1 Gene (MAGUK Family) located in a CpG island encodes 466-aa 52-kDa Palmitoylated Membrane Protein 1, containing 1 PDZ/DHR domain, 1 conserved SH3 domain, 1 guanylate kinase-like domain, and a region that binds to cytoskeletal protein 4.1. Tightly associated with the plasma membrane and extensively palmitoylated, MPP1 interacts with DLG5 and is suspected to play a role in signal transduction. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. (NCI)"                                                                                                                                                                                                                                                                                                   
[23953] "Human MPP2 Gene (MAGUK Family) encodes 576-aa 65-kDa Palmitoylated Membrane Protein 2, suspected to play a role in signal transduction and containing 1 PDZ/DHR domain, a conserved SH3 domain, and 1 guanylate kinase-like domain. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23954] "Human MPP3 Gene (MAGUK Family) encodes 585-aa 66-kDa Palmitoylated Membrane Protein 3, suspected to play a role in signal transduction and containing 1 PDZ/DHR domain, a conserved SH3 domain, and 1 guanylate kinase-like domain. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[23955] "Expressed (4-, 3.8-, and 1.3-kb mRNAs) in all tissues tested (highest in heart, placenta, kidney, and pancreas), human MPZL1 Gene (Ig Superfamily) encodes 269-aa 43-kD hyperphosphorylated cell surface membrane glycoprotein Myelin Protein Zero-Like 1 Protein, containing an N-terminal signal sequence, an extracellular Ig-like domain with potential N-linked glycosylation sites, a single membrane-spanning segment, and an intracellular pair of consensus immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Specifically binding through its ITIMs to tyrosine phosphatase PTPN11, a positive transducer of growth factor signal transduction, MPZL1 is dephosphorylated by PTPN11, but not by PTPN6, which has a negative role in hematopoietic cell proliferation. Having 45.8% identity with Myelin Protein Zero, MPZL1 may have a role in cell signaling via c-Src. (NCI)"                                                                                                    
[23956] "Induced by IL9, but not IL2 or IL4, in brain and heart only, human MRAS Gene (Ras GTPase Family) encodes 208-aa 24-kDa RAS-Related Protein MRAS, a GTP-binding protein implicated in neuronal differentiation and activated by NGF, basic FGF, and guanine nucleotide exchange factor GRP, but not by EGF. Activating the MAP kinase pathway, MRAS may serve as a signal transducer to couple specific trophic factors to the MAPK cascade for cell proliferation through activation of B-Raf. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[23957] "This gene is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The protein encoded by this gene, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. Encodes an inositol 1,4,5-triphosphate-associated cGMP kinase substrate. Calcium release from the endoplasmic reticulum controls a number of cellular processes, including proliferation and contraction of smooth muscle and other cells and contributes to the antiproliferative and proapoptotic effects of nitric oxide and cGMP. (from LocusLink and OMIM)"                                                                                                                                                                                                            
[23958] "The gene encodes musculin that contains a transcriptional repression domain and is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. MSC is a downstream target of the B-cell receptor signal transduction pathway. Mice engineered to lack the protein lack muscle structures derived from the first brachial arch. (from LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23959] "This gene encodes a receptor of the MET receptor family. The protein is membrane-spanning disulfide-linked heterodimer with intracellular tyrosine kinase activity.  It is synthesized as a single polypeptide which is processed to the 185-kD heterodimer of 35-kD (alpha) and 150-kD (beta) subunits joined by the predicted disulfide linkage. The protein is a specific cell surface receptor for macrophage stimulating protein. Targeted expression in mice results in frequent, multiple lung tumors. It may also play a role in progression of some colorectal cancers (from OMIM, Oncogene 2002;21:6382-6 and Oncogene 2003;22:186-97)"                                                                                                                                                                                                                                                                                                                                                   
[23960] "Expressed in many tissues as isoforms short Type A (high in skeletal muscle) or long Type B1 (low level), human MTCP1 Gene (TCL1 Family) encodes 68-aa 8-kDa (A) or 107-aa 13-kDa (B1) mitochondrial Mature T-Cell Proliferation 1 Protein that likely has a role in mature T cell proliferation. MTCP1 is overexpressed in T-cell leukemia bearing a t(X;14) translocation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23961] "Called MuSK for muscle-specific kinase. It is a receptor-like tyrosine kinase restricted to skeletal muscle in its expression. Mice lacking MuSK show a defect in initiation of postsynaptic differentiation. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[23962] "Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a trancriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. The protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. MXI1 maps to a region of chromosome 10 that is deleted in some cases of prostate cancer. (LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                            
[23963] "Widely expressed as a 4.5-kb transcript, human MYBBP1A Gene encodes 1328-aa 149-kDa MYB Binding Protein 1A, containing a central acidic region, C-terminal basic amino acid repeats, and potential leucine charged domain motifs throughout. MYBBP1A shares approximately 80% amino acid sequence similarity with the mouse and rat Mybbp1a homolog, a ubiquitous nucleolar protein that specifically interacts with leucine zipper motifs in the MYB negative regulatory domain (NRD) to modulate MYB hemopoietic cell proliferation and differentiation activity. Disruption of the MYB NRD leucine zipper motif, increases MYB DNA binding, transactivation, and transformation. (NCI)"                                                                                                                                                                                                                                                                                                          
[23964] "Expressed in most nonlymphoid tissues including prostate, lung, liver, and colon, human N33 Gene (OST3 Family) encodes 348-aa 40-kDa N33 Protein, a potential integral membrane protein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23965] "Expressed in adult and fetal tissues, 52-exon 420-kb human NAG Gene encodes 1352-aa 153-kDa and 2371-aa 268-kDa isoforms of Neuroblastoma-Amplified Protein. The NAG 5-prime region contains a CpG island, a TATA box, a CCAAT box, and SP1, OCT1, and MYC binding sites. The 1,352-aa protein contains a C-terminal leucine zipper domain and a ribosomal protein S14 signature domain. In addition, the 2,371-aa protein contains an N-terminal leucine zipper motif, 3 putative transmembrane helices, an endoplasmic reticulum signal sequence, and 2 peroxisomal targeting signals. NAG has 2 clusters of nuclear localization signals, one in the N-terminus of the longer variant and the other in the common C-terminus. NAG shares 83 to 86% identity with orthologous mammalian proteins. The C-terminal leucine zipper and ribosomal S14 motif are not conserved in plant and nematode proteins. (NCI)"                                                                                  
[23966] "Human NCK2 Gene encodes ubiquitous 380-aa 43-kDa cytoplasmic NCK Adaptor Protein 2, containing 1 SH2 domain and 3 SH3 domains, and associates with tyrosine-phosphorylated growth factor receptors or their substrates. NCK2 interacts with PINCH and DOCK1. NCK2 shares 68% amino acid identity with NCK-alpha; most differences occur outside the SH2/SH3 domains. NCK2 associates with PDGF and EGF receptors via p62DOK and inhibits DNA synthesis. NCK2 binds to B ephrin cytoplasmic domains in a phosphotyrosine-dependent manner. NCK2-dependent (SH2 domain) B ephrin signaling increases FAK activity, redistributes paxillin, inhibits focal adhesions, and disassembles F-actin fibers. NCK2 SH3 domains bind proteins implicated in cytoskeletal regulation: CAP/ponsin, ABI1, dynamin, PAK1, HNRNPK, and axin. (NCI)"                                                                                                                                                                 
[23967] "Expressed in fetal brain, lung, liver, and kidney, human NCYM Gene encodes 109-aa 12-kDa DNA-Binding Transcriptional Activator NCYM, containing a helix-loop-helix motif and a basic region. NCYM appears to function as a DNA-binding protein during normal fetal development and is implicated in the pathogenesis of human tumors. The NCYM transcription unit is located on the opposite strand to NMYC, with extensive overlap between the 5-prime ends of the two units. NMYC and NCYM appear to be coregulated under basal growth conditions and in response to retinoic acid. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                        
[23968] "Expressed most prominently in placenta, prostate, kidney, small intestine, and ovary, human NDRG1 Gene (NDRG Family, Alpha/Beta Hydrolase Superfamily) encodes ubiquitous cytoplasmic N-Myc Downstream Regulated Protein 1, also associated with the plasma membrane and nucleus. Downregulated by NMYC and rapidly induced by okadaic acid, a serine/threonine phosphatase inhibitor, increased NDRG1 levels are induced by an elevation of free intracellular calcium ion; cells that border lumenae show highest expression. Involved in stress responses, hormone responses, cell growth, and differentiation, NDRG1 may have a growth inhibitory role. (NCI)"                                                                                                                                                                                                                                                                                                                                  
[23969] "Homolog of the chicken gene neogenin, which is induced in neural cells immediately before cell cycle withdrawal and terminal differentiation. The gene is infrequently affected by alterations in cancer and no alterations in expression were observed in more than 50 cancers studied, including glioblastoma, medulloblastoma, neuroblastoma, colorectal, breast, cervical, and pancreatic cancer cell lines, and xenografts. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23970] "Expressed as a 4.2-kb mRNA in brain, human NEURL Gene encodes 574-aa 62-kDa Neuralized-like Protein, a homolog of neuralized (neu: Drosophila, C. elegans) that appears to be involved in embryonic neurogenic cell fate determination in the central nervous system. Like neu, NEURL contains 2 NHRs (neuralized homology repeats) and a C-terminal RING finger. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23971] "This gene encodes nerve growth factor receptor (NGFR). NGFR was the first member of the large superfamily of tumor necrosis factor receptors. The identification of this superfamily helped elucidate some of the biologic functions of NGFR, including its ultimate involvement in the nuclear factor kappa-B (NFKB) and apoptosis pathways. As a monomer, NGFR binds NGF with low affinity. Higher affinity binding is achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1), TRKB (NTRK2), and TRKC (NTRK3). (OMIM)"                                                                                                                                                                                                                                                                                                                                                                                    
[23972] "Cloned by its ability to interact with the death domain of nerve growth factor receptor. Likely to be involved in nerve growth factor-mediated apoptosis. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23973] "Expressed as a 1.6-kb mRNA in fetal liver and located about 80-kb upstream of PAX9 (oriented head to head), human NKX2H Gene (NK2 Homeobox Family) encodes 239-aa 26-kDa Homeobox Protein NK2 Homolog H, a basic protein related to nk-2 (Drosophila) homeobox transcription factor and containing a homeobox domain and a conserved peptide of nk-2-related proteins. A likely component of PCF (an AFP developmental regulator), NKX2H binds to the AFP gene promoter-linked coupling element (PCE) and activates transcription. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[23974] "Expressed in a largely prostate-specific and androgen-regulated manner, human NKX3-1 Gene (NK-3 Homeobox Family) encodes nuclear Homeobox Protein NKX3A, a transcription factor containing 1 homeobox domain that preferentially binds the consensus sequence TAAGT[AG] and may regulate proliferation of glandular epithelium. NKX3A may interact with SRF and can also behave as a transcriptional repressor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[23975] "Expressed in melanocytes, kidney, placenta, spleen, liver, prostate, and gut, 3-exon human NMA Gene encodes 260-aa 29-kDa (precursor) Putative Transmembrane Protein NMA, containing a signal sequence and a transmembrane domain. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[23976] "A mammalian homolog of amphibian bombesin, Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23977] "NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23978] "Expressed throughout the enteric and central nervous systems, human NMU Gene (NMU Family) encodes 174-aa 20-kDa (precursor) secreted Neuromedin U (25-aa), a potent neuropeptide ligand of G Protein-Coupled Receptor 66 and Neuromedin U Receptor 2 (a GPCR) that stimulates smooth muscle contractions of the ileum, urinary bladder, and uterus, increases blood pressure, alters ion transport in the gut, controls local blood flow, and regulates adrenocortical function. The precursor contains a signal peptide and 4 paired basic residues, putative proteolytic processing sites, indicating that the precursor may generate 3 peptides, including NMU located near the C terminus. (NCI)"                                                                                                                                                                                                                                                                                               
[23979] "Expressed in adult/fetal tissues, human NOTCH1 Gene (Notch Family) encodes 2556-aa 273-kDa phosphorylated type 1 transmembrane Notch Homolog 1, containing 36 extracellular EGF domains, 3 Lin/Notch repeats, and multiple intracellular domains, including 5 ANK repeats. Cleaved by a Golgi furin-like convertase, cell surface Notch protein is a disulfide linked N-/C-terminal heterodimeric receptor for membrane-bound Jagged1, Jagged2, Delta1, and Serrate on adjacent cells that activates an conserved intercellular signaling pathway (lateral inhibition) to regulate cell-fate determination, differentiation, proliferation, and apoptotic programs. Activated Notch cleavage by TACE and presenilin dependent gamma-secretase releases the intracellular domain to form a transcription complex with RBP-J kappa to activate enhancer of split genes. NOTCH1 interacts with DTX1 and DTX2 and may regulate thymic lymphocyte maturation. (NCI)"                                     
[23980] "Expressed by heart and vasculature, human NPR2 Gene (Guanylyl Cyclase Family) encodes type I integral membrane protein Natriuretic Peptide Receptor B, the primary receptor for C-type natriuretic peptides that cause natriuresis, sodium excretion in the urine. NPR2 contains an extracellular ligand-binding domain, a membrane-spanning region, and an intracellular protein kinase homology domain, oligomerizing helical hinge region, and a C-terminal guanylyl cyclase catalytic domain activated upon receptor ligand binding. NPR2 seems to be more effectively stimulated by BNP than by ANP. NPR1 and NPR2 are ANP receptors with guanylate cyclase activity; NPR3 is probably responsible for ANP clearance from the circulation without a role in signal transduction. (NCI)"                                                                                                                                                                                                        
[23981] "Broadly expressed as 3.0-kb and 6.0-kb transcripts, human NR1 Gene (FNR Family) encodes 597-aa 67-kDa cytoplasmic NADPH-Dependent FMN and FAD Containing Oxidoreductase, an enzyme homologous to cytochrome P-450 reductase that binds FMN, FAD, and NADPH cofactors, reduces cytochrome c, and metabolizes electron acceptors doxorubicin, menadione, and potassium ferricyanide. NR1 shares 41 to 44% similarity with nitric oxide synthase-2, methionine synthase transferase, and P-450 reductase. It may play a role in metabolic activation of bioreductive anticancer drugs and other chemicals activated by 1-electron reduction. (NCI)"                                                                                                                                                                                                                                                                                                                                                    
[23982] "Expressed as a 2.4-kb transcript, human NRBP Gene encodes ubiquitous 535-aa 60-kDa Nuclear Receptor Binding Protein, a putative adaptor protein containing 2 putative nuclear receptor-binding motifs, a putative binding domain for SH2 domain-containing proteins, a kinase-like domain, a bipartite nuclear localization signal, and 3 PEST sequences. Mouse and rat NRBP homologs exhibit 91% and 89% identity with NRBP. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[23983] "The cell adhesion molecules (CAMs) are a subset of the immunoglobin (Ig) superfamily found in the nervous systems of both vertebrates and invertebrates. They are usually surface membrane proteins with multiple Ig domains at their N termini followed by several fibronectin type III repeats and either a transmembrane intracellular domain or a glycophosphatidylinositol-linked membrane anchor at the C terminus. (Lane et al., 1996 [PubMed 8812479])"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[23984] "Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. There are six NRG2 alternatively spliced transcripts which are variable between the epidermal growth factor-like (EGF-like) and the transmembrane domains. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. (LocusLink)"                                                                                                          
[23985] "Human NRP1 Gene (Neuropilin Family) encodes Neuropilin 1, containing 1 MAM, 2 F5/8 type C, and 2 CUB domains. Found in embryonic nervous system, and adult heart, placenta lung, liver, skeletal muscle, kidney, and pancreas, type I membrane-bound 923-aa 103-kDa (precursor) isoform 1, expressed by blood vessels, acts as a receptor in cardiovascular development, angiogenesis, formation of neuronal circuits, and organogenesis. Binding to semaphorin 3A, PLGF-2, VEGF-165, and VEGF-B, Isoform 1 appears to mediate chemorepulsion by semaphorins, to increase VEGF-165 binding to KDR, and to regulate VEGF-induced angiogenesis. Expressed in hepatocytes and kidney distal/proximal tubules, secreted 644-aa isoform 2 may bind semaphorins and induce apoptosis by sequestering VEGF-165; it has an adverse effect on blood vessel integrity. Expression of isoforms 1 and 2 does not seem to overlap. (NCI)"                                                                        
[23986] "This gene encodes neurturin, a member of the TGF-beta subfamily. This gene signals through RET and a GPI-linked co-receptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[23987] "This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. This gene is closely related to both nerve growth factor and brain-derived neurotrophic factor. The protein encoded by this gene may be involved in the maintenance of the adult nervous system, and affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of NTF3 is identical in all mammals examined including human, pig, rat and mouse. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                  
[23988] "Widely expressed in adult tissues (highest in heart, small intestine, colon, liver, and prostate), human NTN1 Gene (Laminin Family) encodes 604-aa 68-kDa (precursor) Netrin 1, containing an N-terminal laminin domain, 3 laminin EGF-like domains, and an NTR domain. NTN1 binds to DCC and is thought to be involved in CNS and peripheral motor axon guidance and cell migration during development. Defects in NTN1 are associated with some neuroblastomas. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[23989] "Widely expressed (mainly neural tissue), human NTRK2 Gene (IR Tyr Kinase Family) encodes alternative isoforms TRKB (822-aa 92-kDa precursor), TRKB-T1 (477-aa), and TRKB-T-SHC (537-aa) of Neurotrophic Tyrosine Kinase Receptor Type 2, a type I membrane receptor for BDNF, NTF3, and NTF4/5, but not NGF, involved in development and/or maintenance of the nervous system that contains 2 LRR repeats and 2 Ig-like C2-type domains. Monomeric (low affinity) and dimeric (high affinity) forms appear to exist in dynamic equilibrium. Known substrates for TRK receptors are SHC, PI-3 kinase, and PLC-gamma-1. NTRK2 undergoes ligand-mediated auto-phosphorylation. (NCI)"                                                                                                                                                                                                                                                                                                                  
[23990] "Widely expressed (mainly nervous tissue), human NTRK3 Gene (IR Tyr Kinase Family) encodes alternative isoforms A (839-aa 94-kDa precursor), B (612-aa), C (825-aa), and D (830-aa) of Neurotrophic Tyrosine Kinase Receptor Type 3, a type I membrane receptor for NTF3 containing 2 LRR repeats and 2 Ig-like C2-type domains. Monomeric (low affinity) and dimeric (high affinity) forms appear to exist in dynamic equilibrium and the isoforms do not have identical signaling properties. Known substrates for TRK receptors are SHC, PI-3 kinase, and PLC-gamma-1. NTRK3 undergoes ligand-mediated auto-phosphorylation. (NCI)"                                                                                                                                                                                                                                                                                                                                                               
[23991] "This gene encodes a structural component of the nucleus; predicted role in nuclear reassembly in late mitosis; contains a predicted coiled-coil domain.(LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[23992] "Expressed in thymus, spleen, bone marrow, kidney, brain, and testis, human NUP214 Gene (FG-Repeat NUP Family) encodes 2090-aa 214-kDa homodimeric Nuclear Pore Complex Protein NUP214, likely glycosylated, containing F-G repeats, and associated with cytoplasmic filaments and the cytoplasmic face of the nuclear pore complex. NUP214 is required for proper cell cycle progression and, as a nuclear pore component, may regulate nucleocytoplasmic transport by serving as a docking site in receptor-mediated nuclear import. NUP214 interacts with DDX19 and NUP88. Involved in some cases of leukemia, chromosomal translocation t(6;9)(p23;q34) results in a DEK-NUP214 fusion gene, while chromosomal translocation t(6;9)(q21;q34.1) involves a NUP214/SET gene fusion. (NCI)"                                                                                                                                                                                                         
[23993] "Human OR1G1 Gene (GPCR1 Family) encodes 313-aa 35-kDa integral membrane protein Olfactory Receptor 1G1, a putative odorant receptor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[23994] "Ubiquitously expressed (highest in pancreas, lowest in liver) human OS4 Gene (NIF Family) encodes 283-aa 32-kDa Nuclear LIM Interactor-Interacting Factor 2, a phosphatase that may interact with LDB1. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[23995] "Human OSMR Gene encodes 111-kDa 979-aa Oncostatin-M Specific Receptor Beta Subunit, a subunit with gp130 (a common subunit of IL6 family receptors) for a heterodimeric OSM receptor complex. OSMR contains characteristic motifs of the hematopoietin receptor family. OSM may bind to the gp130 subunit. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[23996] "Human P37NB Gene encodes 313-aa 37-kDa Leucine Rich Repeat Containing Protein 17, of unknown function. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[23997] "Human PAG Gene encodes ubiquitous 432-aa 47-kDa Phosphoprotein Associated with GEMs, a type III plasma transmembrane adaptor protein located predominantly in membrane rafts (GEMs), associated with FYN and CSK tyrosine kinase, and thought to be involved in T cell activation and immunoreceptor signal transduction. PAG contains a 16-aa extracellular domain, a transmembrane domain, a putative palmitoylation site, and a 397-aa cytoplasmic tail with 9 potential tyrosine phosphorylation sites, ITAM-like motifs, and multiple putative casein kinase II and protein kinase C phosphorylation sites. Two Pro-rich sequences may bind to SH3 domains. PAG recruits CSK to the plasma membrane, independent of FYN. After T-cell activation, association with CSK, but not FYN, decreases. PAG/CSK may increase the signaling threshold for initiating an immune response, keeping lymphocytes in a resting state. (NCI)"                                                                 
[23998] "This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. (LocusLink)"                        
[23999] "The PARD6A gene encodes Tax Interaction Protein 40, which belongs to the PAR6 family. It is an adapter protein involved in asymetrical cell division and cell polarization processes. It is probably involved in the formation of epithelial tight junctions. Its association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. (from Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24000] "The tumor suppressor WT1 represses and activates transcription. Apoptosis response protein is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. Apoptosis response protein is specifically upregulated during apoptosis of prostate cells. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24001] "The PAX3 gene encodes Paired Box Protein Pax-3, which is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. (from LocusLink)"                                                                                                                                                                                                                                                                                                    
[24002] "The PAX5 gene encodes Paired Box 5, a member of the paired box (PAX) family of transcription factors. Paired Box 5 is expressed at early stages of B-cell differentiation. Its expression is also detected in developing CNS and testis. Paired Box 5 may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. This gene is located in chromosome 9p13 region, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoters. Deregulation of PAX5 gene transcription may contribute to the pathogenesis of these lymphomas. (from LocusLink)"                                                                                                                                                                            
[24003] "The PAX7 gene encodes Paired Box Protein Pax-7, which is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of Paired Box Protein Pax-7 is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Alternative splicing in this gene has produced two known products but the biological significance of the variants is unknown. (from LocusLink)"                                                                                                                                                                                                                                                                                                
[24004] "The PBEF gene encodes Pre-B-Cell Colony-Enhancing Factor, a cytokine that acts on early B-lineage precursor cells by enhancing the effect of IL-7 and SCF on pre-B-cell colony formation. This protein is secreted and expressed in large amounts in bone marrow, liver tissue, and muscle. It is also present in heart, placenta, lung, and kidney tissues. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24005] "The PBX3 gene encodes Pre-B-Cell Leukemia Transcription Factor 3. This protein is a transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Four alternative products result from alternative splicing. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24006] "The PCTK1 gene encodes PCTAIRE Protein Kinase 1, which belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. This protein may play a role in signal transduction cascades in terminally differentiated cells. The PCTK1 gene is thought to escape X inactivation. There are three alternatively spliced transcript variants described for this gene. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24007] "The PDC gene encodes Phosducin, a phosphoprotein that is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                           
[24008] "Expressed as 2 alternative isoforms in platelets, human PDGFA Gene (PDGF/VEGF Family) encodes Platelet-Derived Growth Factor Alpha, a mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released by platelets upon wounding to stimulate adjacent cell growth. PDGFA can exist as either antiparallel disulfide-linked homodimers or heterodimers with Platelet-Derived Growth Factor Beta. A long PDGFA isoform contains a basic insert that acts as a cell retention signal. A-A, B-B, and A-B, dimers can bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. (NCI)"                                                                                                                                                                                                                                                                                                           
[24009] "The PDGFRA gene encodes Platelet-Derived Growth Factor Receptor, Alpha Polypeptide, which is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. (from LocusLink)"                                                                                                                                                                                                              
[24010] "The PDGFRB gene encodes Platelet-Derived Growth Factor Receptor, Beta Polypeptide, which is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETS, leukemia gene, results in chronic myelomonocytic leukemia. (from LocusLink)"                                                                                                
[24011] "The PDGFRL gene encodes Platelet-Derived Growth Factor Receptor-Like Protein, which has significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24012] "The PDPK1 gene encodes 3-Phosphoinositide Dependent Protein Kinase-1, which belongs to the Ser/Thr family of protein kinases. This protein phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, p70S6K and p90S6K/RSK. It may play a general role in signaling processes and in development (by similarity). It becomes cytoplasmic and membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane. Three isoforms exist from alternative splicing and Isoform 3 is catalytically inactive. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                   
[24013] "The PGF gene at 14q24-q31 encodes Placental Growth Factor, which belongs to the PDGF/VEGF growth factor family. Placental Growth Factor is active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. Three isoforms exist from alternative splicing. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24014] "Widely expressed, human PIAS3 Gene encodes 619-aa 67-kDa Protein Inhibitor of Activated STAT3, containing a SAP domain and a MIZ-type zinc finger, that specifically inhibits the DNA-binding signaling activity of activated STAT3, a latent cytoplasmic transcription factor that becomes activated by tyrosine phosphorylation in response to cytokine stimulation. PIAS3 shares 83% identity with mouse Pias3, approximately 55% identity with PIAS1 and PIASX proteins, and 39% identity with PIASY. Independent of STAT3 binding and by direct binding, PIAS3 also appears to block MITF DNA-binding and transcription activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                       
[24015] "The PIK3CB gene encodes Phosphoinositide-3-Kinase, Catalytic, Beta Polypeptide, which belongs to the PI3/PI4-kinase family. Phosphatidylinositol 3 Kinase is a heterodimer of a P110 (catalytic) and a P85 (regulatory) subunit. It phosphorylates PTDINS, PTDINS4P and PTDINS(4,5)P2 with a preference for PTDINS(4,5)P2. (from Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24016] "The PIK3CG gene encodes Phosphoinositide-3-Kinase, Catalytic, Gamma Polypeptide, which belongs to the PI3/PI4-kinase family of proteins. This protein is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. (from LocusLink)"                                                                                                                                                                                                                                                                                                                         
[24017] "The PIK3CG gene encodes Phosphoinositide-3-Kinase, Regulatory Subunit, Polypeptide 3, which binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. (from Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24018] "The PIK4CB gene encodes Phosphoinositide-4-Kinase, Catalytic, Beta Polypeptide, which belongs to the PI3/PI4-kinase family. This protein phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). It may regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Its enzymatic activity is inhibited by wortmannin. This protein is found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum, and recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2) on the Golgi complex. Two named isoforms exist resulting from alternative splicing. (from Swiss-Prot)"                                                                                                                                                                                     
[24019] "Expressed ubiquitously (high in brain), human PIP5K2A Gene (PtdIns(4)P-5-Kinase Family) encodes 406-aa 46-kDa Phosphatidylinositol-4-Phosphate 5-Kinase Type II Alpha, a likely homodimer that catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-biphosphate, the precursor to second messengers of phosphoinositide signal transduction pathways involved in regulation of secretion, cell proliferation, differentiation, and motility. PIP5K2A does not show homology to other kinases, but the protein does exhibit kinase activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                     
[24020] "The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. Two transcript variants encoding different isoforms have been found for this gene. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                            
[24021] "Expressed in many cells, human PLA2G2A Gene (PLA2 Type II Family) encodes identical membrane-bound and secreted forms of 144-aa 16-kDa (precursor) Phospholipase A2 Group IIA, which catalyzes calcium-dependent hydrolysis of sn-2 fatty acid acyl ester bonds in 3-sn-phosphoglycerides, releasing free fatty acids and lysophospholipids. Thought to regulate biomembrane phospholipid metabolism and eicosanoid biosynthesis, PLA2G2A is likely involved in a variety of cellular processes, including production of precursors for inflammatory reactions. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                              
[24022] "Expressed (1.35-kb mRNA) in activated, but not resting, macrophages and in placenta, prostate, colon, and kidney, 2-exon human PLAB Gene (BMP/TGF-Beta Family) encodes 308-aa 34-kDa (precursor) Placental TGF-Beta, processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in a disulfide-linked homodimeric secreted mature protein of 224 amino acids. PLAB regulates tissue differentiation and maintenance and reduces the growth of granulocytes and macrophages. Unlike most TGFB superfamily members, in which the amino acid sequence is completely conserved, PLAB shares only 70% amino acid identity with its rodent counterparts. (NCI)"                                                                                                                                                                                                                                                                        
[24023] "About 60-kb downstream of NV149 and widely expressed (only from paternal allele), human PLAGL1 Gene (Krueppel Family) encodes 411-aa 45-kDa DNA-binding transcriptional activator Pleiomorphic Adenoma-Like Protein 1, containing 7 C2H2-type zinc fingers, that inhibits cell proliferation through induction of the p53 apoptosis and cell cycle arrest pathways. PLAGL1 also regulates pituitary adenylate cyclase-activating polypeptide type 1 receptor, a potent insulin secretagogue and mediator of autocrine control of insulin secretion in the pancreatic islets. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                 
[24024] "High affinity cellular receptor for urokinase plasminogen activator (uPA).  Plays a role in plasminogen activation by facilitating the conversion of uPA to an enzymatically active form anchored to the cell membrane, where plasminogen activation occurs.  Affects tissue remodeling (surface proteolysis, cell adhesion, cell migration), and cancer invasion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24025] "Expressed in many tissues (4.4-kb mRNA), 31-exon 17-kb human PLCB3 Gene encodes 1234-aa 139-kDa membrane-bound Phospholipase C Beta 3, containing a PI-PLC X-box catalytic domain, a PI-PLC Y-box catalytic domain, and a C2 domain. Activated in response to stimulation by hormones, growth factors, neurotransmitters, and other ligands, PLCB3 is a key enzyme in initiating receptor-mediated signal transduction by mediating production of DAG and IP3 second messengers. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24026] "Induced by growth-stimulating agents in placenta and colon, human PLK Gene (CDC5/Polo Ser/Thr Kinase Family) encodes conserved 603-aa 68-kDa nuclear Polo-Like Kinase, a serine/threonine kinase containing 2 POLO box domains and localized to centrosomes, centromeres/kinetochores, and the spindle midzone that accumulates during S, is maximal during G2/M, and declines throughout G1. Implicated in organization and function of the mitotic apparatus and required for spermatogenesis, PLK phosphorylation of the cyclin B1 nuclear export signal may target mitosis-promoting factor to the nucleus during prophase, which is essential for induction and coordination of M-phase.  (NCI)"                                                                                                                                                                                                                                                                                               
[24027] "Widely expressed as 6- and 7-kb transcripts at varying levels (highest in Sertoli cells), human PLU-1 Gene (RBBP Family) encodes 1544-aa 176-kDa nuclear RBP2-Like Protein, containing 3 Cys-rich zinc-binding DNA-binding PHD/LAP domains, a DNA-binding dead ringer domain, 5 putative nuclear localization signals, a putative DNA/chromatin binding motif, and other conserved regions of unknown function. With an additional 137 amino acids, 1681-aa 190-kDa RBBP2H1A appears to be an alternate PLU-1 product that shares 56% overall amino acid sequence identity with RBBP2, important in RB tumor suppressor regulation. (NCI)"                                                                                                                                                                                                                                                                                                                                                          
[24028] "Rapidly induced (2.0-kb mRNA) by PMA, p53-responsive immediate-early-response gene human PMAIP1 Gene encodes 54-aa Immediate-Early-Response Protein APR, containing a BH3 motif, that can induce apoptosis in various cells in a BH3-dependent manner. PMAIP1 shows highest similarity to p53- and X-ray responsive Noxa gene (mouse), encoding 103-aa Noxa protein with 2 BH3 motifs. Noxa exhibits BH3-dependent localization to mitochondria and interacts with antiapoptotic BCL2 family proteins, resulting in activation of caspase-9. PMAIP1/Noxa may mediate p53-dependent apoptosis in cells exposed to noxious stresses.  (NCI)"                                                                                                                                                                                                                                                                                                                                                          
[24029] "Expressed in a cell-cycle related manner, human PML Gene (TRIM Family) encodes nuclear phosphoprotein Tripartite Motif Protein TRIM19, a transcription factor and tumor suppressor that regulates the p53 response to oncogenic signals, interacts with SIRT1, and contains a TRIM motif: 3 zinc-binding domains, a RING-type zinc finger, a B-box type 1 zinc finger, a B-box type 2 zinc finger, and a coiled-coil region. Extensive alternative splicing results in fourteen variations of the protein's central and C-terminal regions with an invariant N-terminus. Chromosomal translocation t(15;17)(q21;q21) involving PML and RARA is associated with acute promyelocytic leukemia. (NCI)"                                                                                                                                                                                                                                                                                                 
[24030] "Expressed (2.6-kb transcript) in a variety of tissues (fetal liver and adult pancreas highest), human POV1 Gene encodes 559-aa L-Type Amino Acid Transporter 3, containing a putative secretory signal peptide and a leucine zipper motif. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24031] "Expressed ubiquitously (1.74-kb transcript), human PPAP2A Gene (PAP Family) encodes 284-aa 32-kDa Phosphatidic Acid Phosphatase Type 2A, a type 2 integral plasma membrane glycoprotein enzyme with extracellular activity predicted to contain 6 transmembrane regions and a conserved N-glycosylation site. PPAP2A exhibits 47% sequence identity with PPAP2B and 54% identity with PPAP2C; the C-terminal 40-aa of PPAP2A, PPAP2B, and PPAP2C show greatest divergence. PPAP2A has an active role in metabolic pathways controlling synthesis of glycerophospholipids and triacylglycerols, in hydrolysis and uptake of lipids from the extracellular space, in dephosphorylation of phosphatidic acid to diacylglycerol, and in receptor-activated signal transduction mediated by phospholipase D. (NCI)"                                                                                                                                                                                      
[24032] "The protein encoded by this gene is a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Multiple transcript variants that use alternate promoters and splicing have been identified for this gene. At least three of these variants encode the same isoform. (LocusLink)"                                                                                                                                                                                                                             
[24033] "Expressed as a 1.6-kb transcript, human PPP1CA Gene (PP1 Family) encodes cytoplasmic Protein Phosphatase 1 Catalytic Subunit Alpha, one of 3 catalytic subunits (A, B, or C) of PP1 folded by IPP2 and GSK3 and then complexed to various targeting or regulatory subunits. PPP1CA is inhibited by IPP1 and IPP2. Protein phosphorylation is crucial in the regulation of many cellular functions; the level of phosphorylation is controlled by the actions of opposing kinases and phosphatases. PP1 is a major serine/threonine-protein phosphatase essential for cell division, regulation of glycogen metabolism, muscle contractility protein synthesis, regulation of ionic conductances, and long-term synaptic plasticity/memory. PPP1CA may dephosphorylate postsynaptic density-associated Ca++/calmodulin dependent protein kinase II. (NCI)"                                                                                                                                           
[24034] "Human PPP2R1B Gene (PP2A Subunit A Family) encodes 601-aa 66-kDa Protein Phosphatase 2 Regulatory Subunit A Beta, containing 15 HEAT repeats that form a rod-like structure consisting of alpha helices joined by a hydrophilic loop. PPP2R1B is the constant regulatory scaffolding subunit of PP2 that coordinates assembly of the phosphatase catalytic subunit and various regulatory subunits or cell signaling molecules. A major Ser/Thr phosphatase in cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. PPP2R1B interacts with IPO9. (NCI)"                                                                                                                                     
[24035] "Expression increased on virus induction, human PRDM1 Gene encodes 789-aa 88-kDa PR-Domain Zinc Finger Protein 1, a transcriptional repressor containing a SET domain and 4 C2H2-type zinc fingers. PRDM1 specifically binds to the PRDI (positive regulatory domain I) element of the beta-IFN gene promoter and represses beta-interferon gene expression. PRDM1 also drives maturation of B lymphocytes into Ig secreting cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24036] "Expression increased on virus induction, human PRDM1 Gene encodes 789-aa 88-kDa PR-Domain Zinc Finger Protein 1, a transcriptional repressor containing a SET domain and 4 C2H2-type zinc fingers. PRDM1 specifically binds to the PRDI (positive regulatory domain I) element of the beta-IFN gene promoter and represses beta-interferon gene expression. PRDM1 also drives maturation of B lymphocytes into Ig secreting cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24037] "Human PRKCA Gene (PKC Family) encodes 672-aa 77-kDa Protein Kinase C-alpha, a calcium-activated (likely by the C2 domain), DAG-activated, phospholipid-dependent serine/threonine kinase containing 2 zinc-dependent phorbol-ester/DAG binding domains and a C2 domain that phosphorylates a range of cellular proteins. DAG markedly increases PKC sensitivity to calcium and phospholipids. PKC activation appears to be central in the induction of cellular responses to many ligand-receptor systems and to external stimuli. After GPCR stimulation, and triggered by PKC-dependent serine phosphorylation, RKIP dissociates from RAF1 to associate with and block GRK2 activity. By activating PKC, the receptor signal may be enhanced by removing a RAF1 inhibitor and blocking receptor internalization. A receptor for phorbol ester tumor promoters, PKC may interact with PRKCABP. (NCI)"                                                                                              
[24038] "Highly expressed (6-kb and 4.4-kb mRNA) in brain, lung, prostate, thymus, and intestinal mucosa, human PRKG2 Gene (cGMP Ser/Thr Kinase Family) encodes 762-aa 87-kDa Type II cGMP-Dependent Protein Kinase, a physiologic mediator of cGMP containing 2 cyclic nucleotide-binding domains. Type I and II cGMP-dependent protein kinases are encoded by distinct genes. Human cGKII is 96% identical to mouse and rat cGKII. Though not well understood, cGKII function may mediate intestinal secretion of water and electrolytes. NO and diverse hormones, drugs, and toxins increase intracellular cGMP to activate receptors that regulate a variety of functions, including smooth muscle relaxation, neuronal excitability, and epithelial electrolyte transport. (NCI)"                                                                                                                                                                                                                       
[24039] "Induced by interferon, 17-exon human PRKR Gene (GCN2 Family) encodes 551-aa 62-kDa Interferon-Inducible elF2Alpha Kinase, a homodimeric serine/threonine protein kinase containing 2 DRBM domains that is activated by double-stranded RNA in the presence of ATP. Binding to dsRNA induces PRKR dimerization and activation, leading to autophosphorylation in the activation loop, PRKR phosphorylation of EIF2-alpha, and inhibition of protein synthesis initiation. P58(IPK) inhibition by P52(rIPK) upregulates PRKR activity. IFNG mRNA activates PRKR through a conserved 5-prime UTR pseudoknot to control its own translation yield. HCV envelope protein E2 contains a sequence identical to phosphorylation sites of PRKR and EIF2-alpha. E2 inhibits PRKR inhibitory activity on protein synthesis and cell growth, which may contribute to HCV-associated hepatocellular carcinoma. (NCI)"                                                                                            
[24040] "With 22 coding exons, 15-kb human PTCH2 Gene (Patched Family) encodes 1203-aa transmembrane protein Patched Homolog 2, a possible sonic hedgehog receptor highly similar to PTCH and containing an SSD domain that may have a role formation of embryonic structures and in epidermal development. The Drosophila patched-hedgehog signaling pathway establishes segment polarity and anterior-posterior orientation. The patched pathway is conserved from fly to vertebrates. With 56% identity to Patched-1, mouse Patched-2 diverges in the hydrophilic region between transmembrane domains 6 and 7 and in a region of the intracellular C terminus. (NCI)"                                                                                                                                                                                                                                                                                                                                    
[24041] "Human PTHLH Gene encodes Parathyroid Hormone-Like Hormone, an anti-proliferative factor that, through its signaling receptor PTHR1, regulates endochondral bone development, epithelial-mesenchymal interactions, and epidermal cell growth. Because of structural homology with PTH and binding to the PTH/PTHRP receptor, PTHRP can mimic PTH action, but has evolved to regulate local tissue functions, in contrast to systemic parathyroid hormone function. PTHRP functions as a poly-hormone that gives rise to several active peptides, each of which presumably has its own receptor. It appears to also have intracrine nuclear effects in cells that produce it, in addition to autocrine, juxtacrine, paracrine, and possibly endocrine effects. (NCI)"                                                                                                                                                                                                                                 
[24042] "Ubiquitously expressed (most in brain), human PTK2 Gene (FAK Family) encodes Focal Adhesion Kinase 1, a cytoplasmic nonreceptor tyrosine kinase. An endogenous substrate for insulin receptor associated tyrosine kinase and for pp60v-src, tyrosine phosphorylated/activated PTK2 contains a FERM domain and a C-terminal FAT sequence that mediates localization to focal adhesions. Activated by adhesion-induced integrin clustering, neural peptides, ligand-GPCR occupancy, or LDL receptor occupancy, PTK2 is implicated in signaling pathways involved in cell motility, proliferation, and apoptosis. Via interaction of a PTK2 Pro-rich region with an SH3 domain, PTK2 interaction with CRK-associated tyrosine kinase substrate p130-CAS and CASL may be key in integrin-mediated signal transduction and may link SRC and CRK oncoproteins.  (NCI)"                                                                                                                                    
[24043] "This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. PTK2B has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. Four transcript variants encoding two different isoforms have been found for this gene. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                  
[24044] "The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24045] "Expressed in lung, liver, pancreas, kidney, placenta, melanocytes, thyroid gland, ovary, brain, heart, and skeletal muscle (but not in colon), human PTK7 Gene (INSR family) encodes 1070-aa 118-kDa (precursor) PTK7 Protein Tyrosine Kinase 7, a type I membrane protein containing 7 Ig-like C2-type domains that appears to lack tyrosine kinase catalytic activity and may function as a cell adhesion molecule. PTK7 may be a colon carcinoma tumor progression marker. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24046] "Encodes a secreted growth factor that is mitogenic for endothelial, epithelial, and fibroblast cells but can also induce neurite outgrowth.  It functions as a growth factor during neonatal brain development, for primate trophoblast formation, and during tumor invasion, angiogenesis, and metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24047] "Human PTP4A1 Gene (PTP Family) encodes Protein Tyrosine Phosphatase IVA1, a regulatory cell signaling nuclear tyrosine phosphatase primarily associated with the plasma membrane that belongs to a small class of prenylated PTPs, contains a PTP domain and a characteristic C-terminal prenylation motif, and may be an immediate-early gene product in mitogen-stimulated cells. The surface membrane association of PTP4A1 depends on C-terminal prenylation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24048] "This gene encodes the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. (LocusLink)"                                                                                                                                                                                                                           
[24049] "Human PTPN12 Gene (Non-Receptor PTP Family) encodes 780-aa 88-kDa cytoplasmic Non-Receptor Type 12 Protein Tyrosine Phosphatase, containing a C-terminal PEST motif protein-protein interaction domain. PTPN12 binds to and dephosphorylate the c-ABL product. It also interacts with, and dephosphorylates, cytoskeletal and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and Paxillin, suggesting a role in controlling cell shape and mobility. PTPs typically regulate cell growth, differentiation, and mitotic cycle. Defects in PTPN12 are found in some colon cancers. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                       
[24050] "This gene encodes a protein tyrosine phosphatase which is expressed primarily in lymphoid tissues. This enzyme associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24051] "Expressed predominantly in hematopoietic cells, human PTPN6 Gene (Non-Receptor PTP Family) encodes 3 distinct alternative isoforms of cytoplasmic serine/tyrosine phosphorylated Non-Receptor Type 6 Protein Tyrosine Phosphatase, containing two tandem N-terminal phosphotyrosine binding SH2 domains that mediate interaction with substrates and may modulate phosphatase activity through interaction with other cellular components. A key regulator of hematopoiesis, PTPN6 interacts with, and dephosphorylates, many phosphoproteins involved in hematopoietic cell signaling pathways. PTPN6 binds to PTPNS1, LILRB1, and LILRB2. Protein Tyrosine Phosphatases typically regulate cell growth, differentiation, and mitotic cycle. (NCI)"                                                                                                                                                                                                                                                
[24052] "Preferentially expressed as 2 distinct alternative isoforms in thymic and spleen hematopoietic cells, human early response PTPN7 Gene (Non-Receptor PTP Family) in lymphokine-stimulated cells encodes cytoplasmic Non-Receptor Type 7 Protein Tyrosine Phosphatase, likely involved in regulation of TCR signaling through dephosphorylating MAP kinase pathway molecules; the noncatalytic N-terminus interacts with and suppresses MAP kinase activities. PTPN7 appears to regulate T and B lymphocyte development and signal transduction. Protein Tyrosine Phosphatases typically regulate cellular processes including cell growth, differentiation, and mitotic cycle. (NCI)"                                                                                                                                                                                                                                                                                                                
[24053] "This gene encodes a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. (LocusLink)"                                                                                    
[24054] "The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. (RefSeq)"                                                                           
[24055] "Human PTPRE Gene (PTP Family) encodes alternative isoforms of Protein Tyrosine Phosphatase Epsilon, containing 2 PTP domains. Alternative transcript 1 encodes 700-aa 81-kDa (precursor) Protein Tyrosine Phosphatase Receptor Type Epsilon Isoform 1, a type I membrane protein receptor-type PTP with a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. Alternative transcript 2 encodes 642-aa Protein Tyrosine Phosphatase Epsilon Isoform 2, a nonreceptor-type cytoplasmic PTP with a distinct hydrophilic N-terminus. Studies of the mouse PTPRE homolog suggest a regulatory role for PTPRE in RAS related signal transduction pathways, cytokine-induced SATA signaling, and activation of voltage-gated K+ channels. (NCI)"                                                                                                                                                                                                 
[24056] "Expressed in many tissues (likely developmentally regulated in brain), human PTPRG Gene (PTP Family) encodes Protein Tyrosine Phosphatase Receptor Type G, a likely type I membrane protein receptor-type PTP with an extracellular region containing an eukaryotic-type CAH domain and a fibronectin type III domain, a single transmembrane region, and two tandem intracytoplasmic catalytic PTP domains. PTPs typically regulate cell growth, differentiation, and mitotic cycle. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24057] "Expressed in all hematopoietic lineages, human PTPRJ Gene (PTP Family) encodes 1337-aa 146-kDa (precursor) N- and O-glycosylated type I membrane Protein Tyrosine Phosphatase Receptor Type J, a receptor-type PTP with an extracellular region containing 9 fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic PTP catalytic domain. PTPRJ negatively regulates TCR signaling, possibly by interfering with phosphorylation of PLCG1 and LAT. PTPRJ also dephosphorylates the PDGF beta receptor, may be involved in UV-induced signal transduction, and may contribute to contact inhibition of cell growth. Defects in PTPRJ are found in cancers of colon, lung, and breast. (NCI)"                                                                                                                                                                                                                                                                     
[24058] "Expressed in brain, kidney, placenta, small intestine, stomach, uterus, or prostate, human PTPRR Gene (PTP Family) encodes alternative alpha, beta, gamma, and delta isoforms of Protein Tyrosine Phosphatase PCPTP1. Type I membrane protein receptor-type PTP isoforms alpha and beta possess an extracellular region, a single transmembrane region, and a single intracellular catalytic domain. Cytoplasmic nonreceptor-type PTP isoforms gamma and delta contain 1 PTP domain and locate in the perinuclear area. PTPRR sequesters inactive MAPKs, such as MAPK1, MAPK3, and MAPK14, in the cytoplasm. MAPKs likely bind to a dephosphorylated kinase interacting motif, phosphorylation of which by Protein Kinase A complex releases MAPKs for activation and nuclear translocation. Mouse Ptprr is expressed predominately in the brain and regulates MAP kinase activity and localization. (NCI)"                                                                                         
[24059] "Expressed in the central nervous system, human PTPRT Gene (PTP Family) encodes type I membrane Protein Tyrosine Phosphatase Receptor Type T, a receptor-type PTP with an extracellular region containing 4 fibronectin type III domains, 1 Ig-like C2-type domain, and 1 MAM domain; a single transmembrane region; and 2 tandem intracellular PTP catalytic domains. PTPRT may be involved in signal transduction and cellular adhesion in the CNS. PTPs typically regulate cell growth, differentiation, and mitotic cycle. The mouse protein structure and expression also suggest a role in signal transduction and cellular adhesion in the central nervous system. (NCI)"                                                                                                                                                                                                                                                                                                                     
[24060] "Highly expressed in testis and spleen as two alternative transcripts, human RAD54B Gene (SNF2/SWI2 Family) at 8q21.3-q22 encodes different isoforms of 910-aa 100-kD nucleoplasmic RAD54B Homolog, with significant homology to RAD54 and motifs similar to DNA and RNA helicases. RAD54B binds to double-stranded DNA and displays DNA-associated ATPase activity. RAD54B appears to associate indirectly with RAD51 through its N-terminal domain and may colocalize with RAD54 and BRCA1. Part of a complex involved in meiotic and mitotic homologous DNA recombination repair, RAD54B plays a critical role in targeted integration and recombination in concert with other RAD52 epistasis group members without affecting cell growth, sensitivity to DNA damaging agents, or sister chromatid exchange. (NCI)"                                                                                                                                                                              
[24061] "Human RAGA Gene at 9-21.3 encodes RAS-Related GTP-Binding Protein RAGA, a RAS-related GTP-binding protein lacking GTPase activity that interacts with adenovirus E3 protein and may be part of the TNF Alpha signaling pathway. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24062] "Expressed as a 2.2-kb transcript in heart, brain, lung, kidney, pancreas, placenta, liver, and skeletal muscle, human RAGE Gene (MAPK Family) at 14q32 encodes 419-aa cytoplasmic Renal Tumor Antigen, 84% identical overall to the mouse protein (96% identical in the kinase domain) and structurally similar to other MAPKs, including a TEY motif in the activation loop that probably requires autophosphorylation and is required for kinase activity. MOK phosphorylates myelin basic protein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24063] "Rapidly induced by retinoic acid as 2.4- and 6.8-kb transcripts, human RAI3 Gene (GPCR3 Family) at 12p13-p12.3 encodes 357-aa 40-kDa Retinoic Acid Induced 3 protein, containing 7 predicted GPCR-signature transmembrane domains and a potential N-linked glycosylation site. Likely involved in the interaction between retinoid acid and G protein signaling pathways, RAI3 may play a role in embryonic development and epithelial cell differentiation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24064] "Human RALGDS Gene at 9q34.3 encodes 914-aa 101-kDa RAL Guanine Nucleotide Dissociation Stimulator, a guanine nucleotide exchange factor containing an N-terminal RAS-GEF domain and a noncatalytic C-terminal RAS-associating domain. RALGDS interaction as an effector molecule with RAS-like molecules is specific and dependent on RAS activation by GTP. RALGDS stimulates dissociation of GDP from RAS-related RALA and RALB GTPases, allowing GTP binding and GTPase activation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24065] "RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                          
[24066] "Human RAP1A Gene (RAS GTPase Family) at 1p13.3 encodes membrane-bound 184-aa 21-kDa (precursor) RAS-Related Protein RAP1A, activated by guanine nucleotide-exchange factors EPAC and EPAC2, in a cAMP-dependent manner, and by GFR. Interacting with RAS GAPs and RAF in a competitive manner, RAP1A counteracts RAS mitogenic function. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24067] "Human RARB Gene (NR1 Family) at 3p24 encodes 4 alternative isoforms of Retinoic Acid Receptor Beta (1-4), composed of three domains: an N-terminal modulating domain, a central DNA-binding domain, and a C-terminal ligand-binding domain. RARB controls embryonic morphogenesis, cell proliferation, and differentiation by directly regulating gene transcription. RARB appears to limit growth of many cell types. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24068] "One of three retinoic acid receptor responders induced by the synthetic retinoid tazarotene. Overexpression of RARRES3 inhibited the growth of many cell lines, suggesting that RARES3 may function as an antiproliferative and antitumor agent. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24069] "Expressed in a variety of tissues (heart strongest), human RASD1 Gene (RASD GTPase Family) at 17p11.2 encodes 281-aa 32-kDa Activator of G-Protein Signaling 1, a dexamethasone inducted RAS-related protein that may play a role in alterations of cell morphology, growth, and cell-extracellular matrix interactions. RASD1 may form a ternary complex with CAPON and NOS1and may function as a physiologic nitric oxide (NO) effector. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24070] "Widely expressed as two alternative transcript variants, human RBBP9 Gene at 20p11.2 encodes 186-aa 21-kDa nuclear/cytoplasmic Retinoblastoma Binding Protein 9, which confers resistance to TGF-Beta 1 growth inhibition through interaction with Rb and subsequent displacement of E2F-1 and may play a role in regulation of cell proliferation and differentiation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24071] "Restricted to G0 expression, human RBL2 Gene (RB Family) at 16q12.2 encodes 1139-aa 128-kDa nuclear Retinoblastoma-Like 2 protein, which binds to adenovirus E1A protein and to cyclins A and E, associates preferentially with E2F5, inhibits E2F-mediated trans-activation, and may function in cell cycle regulation. Ser-672 phosphorylation in G1 leads to ubiquitin-dependent proteolysis of RBL2. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24072] "Widely expressed, human RBM5 Gene at 3p21.3 encodes in as many as 25 exons 815-aa 92-kDa RNA Binding Motif Protein 5, which contains nuclear localization signals, 2 RRM domains, a G-patch domain, and a RANBP2-type zinc finger, and specifically binds to RNA. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24073] "Widely expressed, human RBM6 Gene at 3p21.3 encodes 1,123-aa RNA Binding Motif Protein 6, which contains 20 inexact 6-aa N-terminal repeats, 2 RNA-binding domains, 2 zinc finger motifs, nuclear localization signals, and specifically binds RNA. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24074] "Widely expressed human RBX1 Gene (RING-Box Family) at 22q13.2 encodes conserved cytoplasmic and nuclear 108-aa 12.3-kDa RING Box Protein 1, containing a RING-type zinc finger, that mediates protein turnover of cell cycle, signal transduction, and transcription proteins by ubiquitination and proteasomal degradation. A component of various SCF, SCF-like, and CBC multisubunit E3 ubiquitin ligase complexes, RBX1 may recruit E2 enzymes to the complex through its RING-type zinc finger and heterodimerizies with cullins in the third step of ubiquitin conjugation reactions to catalyze ubiquitin polymerization. RBX1 promotes neddylation of CUL1 and probably CUL2. It also probably interacts with CDC34 and may stimulate CDC34 autoubiquitination. (NCI)"                                                                                                                                                                                                                      
[24075] "Human RCN2 Gene (CREC Family) at 15q23 encodes ubiquitous 317-aa 55-kD calcium-binding Reticulocalbin 2, containing 6 conserved helix-loop-helix EF-hand calcium-binding domains and a C-terminal HDEL sequence required for ER retention. RCN2 appears to interact with human papillomavirus transforming protein E6 and with the vitamin D receptor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24076] "Alternatively spliced transcript variants, alpha and beta, of human RFP Gene (TRIM Family) at 6p22 encode 513-aa 58.5-kDa RET Finger Protein, containing a TRIM motif: 3 zinc-binding domains, a RING, a type 1 and type 2 B-box, and a coiled-coil region. Located in the nuclear matrix, RFP interacts with enhancer of polycomb protein, represses gene transcription, and is thought to be involved in male germ cell differentiation. Gene rearrangements with RET produce RET transforming protein, containing the RFP N-terminus with the RET protein tyrosine kinase. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                
[24077] "Two alternative transcript variants of human RFP2 Gene (TRIM Family) at 13q14 encode 407-aa 47-kDa RET Finger Protein 2, of unknown function, localized to cytoplasmic bodies near the nucleus, and containing a TRIM motif: 3 zinc-binding domains, a RING, a type 1 and a type 2 B-box, and a coiled-coil region. RFP2 may act as a tumor suppressor and may be involved in 13q14 deletion B-CLL. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24078] "Induced in response to several activation signals, 4-kb 4-exon B-cell specific immediate early human RGS1 Gene (RGS Family) at 1q31 encodes 196-aa 22.5-kDa Regulator of G-Protein Signaling 1, containing 1 RGS domain and likely involved in regulation of B-cell activation and proliferation. Potentially regulated by protein kinase(s), RGS1 inhibits signal transduction by increasing GTPase activity of G protein alpha subunits, driving them into the inactive GDP-bound form.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24079] "Expressed most in lung, placenta, liver, and heart, human RGS19 Gene (RGS Family) at 20q13.3 encodes membrane-bound fatty acylated 217-aa 25-kDa Regulator of G-protein Signaling 19, a guanosine triphosphatase-activating protein containing 1 RGS domain that specifically interacts with G protein GAI3 and down-regulates G Alpha i/G Alpha q-linked signaling. Heavily palmitoylated in the Cys string motif and mainly phosphorylated on Ser residues, RGS19 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, driving them into the inactive GDP-bound form. RGS19 binds to G-Alpha subfamily 1 members and interacts with GIPC PDZ domain. (NCI)"                                                                                                                                                                                                                                                                                                
[24080] "Human RGS2 Gene (RGS Family, 5 exons and a 5-prime CpG island) at 1q31 encodes 211-aa 24-kDa Regulator of G-Protein Signaling 2, a basic HLH phosphoprotein containing 1 RGS domain with similarity to lymphocyte-specific 1R20 and phosphorylated by PKC. RGS2 inhibits signal transduction by increasing GTPase activity of G protein alpha subunits, driving them into the inactive GDP-bound form. RGS2 also reduces cAMP production by inhibiting odorant-stimulated Alpha-OLF linked adenylyl cyclase type III activity in olfactory neurons. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24081] "Multiple alternative transcript variants of human RGS3 Gene (RGS Family) at 9q32 encode 519-aa 56.6-kDa cytosolic Regulator of G-Protein Signaling 3, containing 1 RGS domain and likely phosphorylated by cyclic GMP-dependent protein kinase. RGS3 inhibits G-protein mediated signal transduction by increasing G protein alpha subunit GTPase activity, promoting its conversion to the inactive GDP-bound form. G-protein activation leads to translocation of RGS3 to the plasma membrane. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24082] "Human RHOK Gene (GPRK Family) at 13q34 encodes 563-aa 64-kDa membrane-bound Rhodopsin Kinase, containing 1 RGS domain, which regulates GPCR rhodopsin desensitization and initiates rhodopsin deactivation by phosphorylation following light stimulation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24083] "Alternative transcript isoforms of 7-exon 14.5-kb human RIL Gene at 5q31.1 encode 330-aa 35-kDa LIM Domain Protein, containing a LIM zinc-binding domain and a PDZ/DHR domain. The last 2 exons encode the LIM domain. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24084] "The gene product of the gene is a Serine/threonine kinase, and interacts with CD40 or the tumor necrosis factor receptor.  It has a C-terminal domain for caspase recruitment and activation. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24085] "Expressed in heart, brain, placenta, skeletal muscle, kidney, pancreas, spleen, lung, peripheral blood leukocytes, prostate, testis, and colon, human RIPK3 Gene (Ser/Thr Kinase Family) at 14q11.2 encodes autophosphorylated (Lys50) cytoplasmic 518-aa 57-kDa Receptor-Interacting Serine/Threonine Kinase 3, containing a distinct C terminus that interacts with RIPK1and an N-terminal kinase domain similar to RIPK1 and RIPK2. RIPK3 also colocalizes in the mitochondrion with RIPK1. RIPK3 is recruited to the TNFR1 complex in a RIPK1-dependent manner and interacts with TRAF2. The RIPK3 C terminus is required to induce apoptosis through the activation of some or all caspases and also appears to activate NFKB. RIPK3 can stimulate NFKB nuclear translocation. (NCI)"                                                                                                                                                                                                          
[24086] "Human RNF11 Gene at 1pter-p22.1 encodes 154-aa 17-kDa Ring Finger Protein 11, containing a RING-H2 zinc finger motif important for protein-protein interactions. RNF11 may interact with NEDD4. RNF11 expression is induced by mutant RET proteins (MEN2A/MEN2B).  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24087] "Human ROCK1 Gene at 18q11.1 encodes Rho-Associated Coiled-Coil Containing Protein Kinase 1, a Ser/Thr kinase activated when bound to GTP-bound Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between inactive GDP-bound and active GTP-bound forms. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. As a downstream effector of Rho, ROCK phosphorylates and activates LIM kinase, which phosphorylates cofilin and inhibits its actin-depolymerizing activity. (NCI)"                                                                                                                                                                                                                                                                                                                                            
[24088] "Expressed in heart, lung, kidney, and CNS, human ROR1 Gene (ROR/Tyr Kinase Family) at 1p32-p31 encodes 2 alternative isoforms of 937-aa 10-kDa (precursor) type I membrane protein Receptor Tyrosine Kinase-Like Orphan Receptor 1, a receptor protein tyrosine kinase containing a FZ domain, 1 Ig-like C2-type domain, and 1 kringle domain whose cellular function has not been determined. ROR1 may interact with another receptor protein tyrosine kinase and be involved in skeletal and cardiac development. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24089] "Expressed during early embryonic development and only at low levels in adult tissues, human ROR2 Gene (ROR/Tyr Kinase Family) at 9q22 encodes 943-aa 105-kDa (precursor) Receptor Tyrosine Kinase-Like Orphan Receptor 2, a type I transmembrane receptor protein tyrosine kinase containing a FZ domain, an Ig-like C2-type domain, and a kringle domain that may be involved in early formation of chondrocytes and cartilage development. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24090] "Human RORA Gene (NR1 Family) at 15q21-q22 encodes 4 alternative isoforms of monomeric or homodimeric 556-aa 63-kDa nuclear RAR-Related Orphan Receptor A, an orphan hormone receptor that binds to genomic DNA regulatory elements of hormone-responsive genes containing a single core motif half-site preceded by a short A-T-rich sequence. RORA interacts with nucleoside diphosphate kinase NM23-2, involved in organogenesis and differentiation, as well as with metastasis suppressor NM23-1 gene product. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24091] "Down-regulated during adipocyte, kidney, and heart differentiation, human RPL10 Gene (L10E Family) at Xq28 encodes 213-aa 24-kDa cytoplasmic Ribosomal Protein L10, a component of the ribosomal 60S subunit. Ribosomes catalyze protein synthesis and consist of 40S and 60S subunits composed of 4 rRNAs and approximately 80 structurally distinct proteins. RPL10 may bind to and repress c-Jun transcriptional activation. Typical for ribosomal protein genes, there are multiple processed RPL10 pseudogenes throughout the genome. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24092] "Located in the tightly linked Surfeit Gene cluster and co-transcribed with small nucleolar RNA genes located in its introns, human RPL7A Gene (L7AE Family) at 9q34 encodes 265-aa 30-kDa Ribosomal Protein L7a, a component of the 60S ribosomal subunit. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. RPL7A can inhibit a subclass of transactivating nuclear hormone receptors, including THR, by preventing DNA binding. Gene rearrangements with TRK form TRK-2H, which encodes an oncoprotein of the RPL7A N terminus fused to the TRK tyrosine kinase domain. There are multiple processed RPL7A pseudogenes throughout the genome. (NCI)"                                                                                                                                                                                                                                                           
[24093] "The 6-exon 11-kb human RPS19 Gene (S19E Family) at 19q13.2 encodes 144-aa 16-kDa cytoplasmic Ribosomal Protein S19, a component of the 40S ribosomal subunit. S19 lacks cysteine residues and has a possible function in erythropoietic differentiation and proliferation. The first exon is untranslated and the ATG start codon is located at the beginning of exon 2. No TATA or CAAT boxes can be identified. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. There are multiple processed RPS19 pseudogenes dispersed throughout the genome. (NCI)"                                                                                                                                                                                                                                                                                                                                                       
[24094] "Expressed in actively proliferating cells, human RPS27 Gene (S27E Family) at 1q21 encodes 83-aa 9-kDa Ribosomal Protein S27, located in the cytoplasm as a component of the 40S ribosomal subunit but also detected in the nucleus. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. S27 appears to be located near ribosomal protein S18 and to be covalently linked to translation initiation factor eIF3. S27 contains a C4-type zinc finger domain and is able to bind to nucleic acid. Multiple processed RPS27 pseudogenes are dispersed throughout the genome. (NCI)"                                                                                                                                                                                                                                                                                                                                    
[24095] "Human RPS3 Gene (S3P Family) at 11q13.3-q13.5 encodes cytoplasmic and nuclear 243-aa 27-kDa Ribosomal Protein S3, containing a KH type-2 domain and a component of the 40S ribosomal subunit as part of the translation initiation domain. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. RPS3 also appears to be an endonuclease involved in UV-induced DNA repair. RPS3 is co-transcribed with small nucleolar RNA genes located in its first and fifth introns and multiple processed RPS3 pseudogenes are dispersed throughout the genome. (NCI)"                                                                                                                                                                                                                                                                                                                                                         
[24096] "Widely expressed in heart, brain, placenta, lung, kidney, and liver, human RPS6KA5 Gene (S6 Ser/Thr Kinase Family) at 14q31-q32.1 encodes predominantly nuclear 802-aa 90-kDa Ribosomal Protein S6 Kinase Alpha 5, a Ser/Thr kinase that associates with, phosphorylates, and controls NF-Kappa-B p65 subunit (RELA) transcriptional activity in response to TNF. RPS6KA5 activity requires the presence of both kinase domains. Likely activated by ERK1/2 and p38 Ser/Thr phosphorylations, RPS6KA5 transiently dissociates from complexes with ERK1/2 following mitogenic stimulation and may mediate growth factor and stress induced activation of transcription factor CREB. RPS6KA5 also associates with MAPK14/p38alpha. (NCI)"                                                                                                                                                                                                                                                             
[24097] "Human RPS6KB2 Gene (S6 Ser/Thr Kinase Family) at 11q13.1 encodes 482-aa 53-kDa Ribosomal Protein S6 Kinase Beta 2. RPS6KB2 specifically phosphorylates 40S ribosomal protein S6, the major eukaryotic ribosome substrate of many kinases. S6 phosphorylation is stimulated by growth factors and mitogens; dephosphorylation occurs at growth arrest. S6 may control cell growth and proliferation through the selective translation of specific of mRNA classes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24098] "Human RRAS2 Gene (RAS GTPase Family) at 11p15.2 encodes ubiquitous 204-aa 23-kDa RAS-Related Protein R-RAS2, a plasma membrane-associated GTP-binding GTPase that may transduce growth inhibitory signals by exerting an antagonistic effect on a RAS effector. RRAS2 may be posttranslationally modified by palmitoylation and polyisoprenylation. Attachment to the inner surface of plasma membrane may require acylation of a C-terminal cysteine. RRAS2 defects can cause ovarian tumors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24099] "Expressed as a 1.4-kb mRNA in brain, human RRP22 Gene (Small GTPase Family) at 22q12.2 encodes 203-aa 23-kDa RAS-Like Protein RRP22. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24100] "Expressed as multiple alternative transcript variants, human RSU1 Gene at 10p13 encodes RAS Suppressor Protein 1, likely involved in the RAS signal transduction pathway, growth inhibition, and NGF-induced differentiation. RSU1 contains 7 LRR repeats and may antagonize RAS. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24101] "Widely expressed, human RYK Gene (TYR Kinase Family) at 3q22 encodes 604-aa 68-kDa (precursor) RYK Receptor-Like Tyrosine Kinase, a potential growth factor receptor protein tyrosine kinase containing a WIF domain that differs from other family members at a number of conserved residues in the activation and nucleotide binding domains. RYK does not appear to be regulated by phosphorylation in the activation segment and mediation of biological activity may occur by recruitment of a signaling-competent auxiliary protein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24102] "Human S100A11 Gene (S100 Family) at 1q21 encodes 105-aa 12-kDa homodimeric S100 Calcium Binding Protein A11, containing 2 EF-hand calcium-binding motifs, that may function in motility, invasion, and tubulin polymerization. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24103] "Expressed in monocytes and lymphocytes, human S100A12 Gene (S100 Family) at 1q21 encodes 91-aa 10-kDa (precursor) homodimeric S100 Calcium Binding Protein A12, containing 2 EF-hand calcium-binding motifs and involved in regulatory effects on cytoskeletal components and in calcium-dependent signal transduction pathways. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24104] "Constitutively expressed in epithelial cells and in macrophages during chronic inflammation, human S100A8 Gene (S100 Family) encodes 93-aa 11-kDa S100 Calcium Binding Protein A8, a homodimer containing 2 EF-hand calcium-binding motifs that may interact with intermediate filament components and function in casein kinase inhibition. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24105] "Constitutively expressed in epithelial cells and by macrophages in inflamed tissues, human S100A9 Gene (S100 Family) at 1q21 encodes 114-aa 13-kDa S100 Calcium Binding Protein A9, containing 2 EF-hand calcium-binding motifs, which may inhibit protein kinases and interact with intermediate filament components. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24106] "Human S100P Gene (S100 Family) at 4p16 encodes 95-aa 10-kDa S100 Calcium Binding Protein P, containing 2 EF-hand calcium-binding motifs, which binds Ca2+, Zn2+, and Mg2+ and interacts with S100Z. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24107] "Expressed in lung, skeletal muscle, kidney, peripheral leukocytes, spleen, brain, placenta, heart, prostate, testis, ovary, and colon, human SCAP2 Gene (SRC Kinase Family) at 7p21-p15 encodes 359-aa SRC Family Associated Phosphoprotein 2, an adaptor protein implicated in myeloid differentiation and growth arrest and thought to play a role in SRC signal transduction pathways of tyrosine and nontyrosine kinase receptors. Like SKAP55, SKAP55R contains a PH domain, multiple tyrosine phosphorylation sites, and an SH3 domain. Unlike SKAP55, SKAP55R has an N-terminal coiled-coil domain. SKAP55R and SKAP55 are phosphorylated by FYN, but not LCK or ZAP70. Unlike SKAP55, SKAP55R is not constitutively phosphorylated in T cells. FYB in T cells binds SKAP55 and SKAP55R through their SH3 domains. (NCI)"                                                                                                                                                                    
[24108] "Human SCTR Gene (GPCR2 Family) at 2q14.1 encodes 440-aa 50-kDa (precursor) 7 transmembrane integral membrane protein Secretin Receptor, which binds secretin and, mediated by G proteins that activate adenylyl cyclase, regulates pancreatic bicarbonate, enzyme, and potassium ion secretion. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24109] "Induced by PMA in activated T cells, human CCL1 Gene (Intercrine Beta Family) at 17q11.2 encodes secreted immunoregulatory monomeric 96-aa 11-kD (precursor) Small Inducible Cytokine A1 (related to CXC cytokines), which binds to CCR8 receptor and has chemotactic activity for monocytes in inflammatory processes.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24110] "This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil specific chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                 
[24111] "Induced by IL-1 and TNF-alpha and widely expressed, human CCL13 Gene (Intercrine Beta Family) encodes 98-aa 11-kD (precursor) Small Inducible Cytokine A13, a secreted chemotactic factor for monocytes, lymphocytes, basophils, and eosinophils that signals through CCR2B and CCR3 receptors and is involved in immunoregulatory and inflammatory processes. The protein can bind heparin and isoforms MCP-4, (LA)MCP-4, and (FNPQGLA)MCP-4 exist. CCL13 may be involved in artherosclerosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24112] "Constitutively expressed in several tissues, human CCL14 Gene (Intercrine Beta Family) at 17q11.2 encodes secreted 93-aa 11-kD (precursor) Small Inducible Cytokine A14, which acts via MIP-1 alpha receptors to induce intracellular calcium changes and enzyme release in monocytes and to enhance CD34 myeloid progenitor cell proliferation. CCL14 expresses monocistronic and bicistronic transcripts (includes upstream CCL15 gene). The bicistronic transcripts undergo alternative splicing. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24113] "Widely expressed human CCL15 Gene (Intercrine Beta Family), at 17q11.2 encodes secreted 113-aa 12-kDa (precursor) Small Inducible Cytokine A15, a chemotactic factor for T cells and monocytes that acts mainly via CCR1, induces intracellular calcium changes in monocytes, and induces N-acetyl-beta-D-glucosaminidase release in monocytes. CCL15 also binds to CCR3. Monocistronic and bicistronic CCL15 transcripts encode the same protein. The alternatively spliced bicistronic transcripts include the downstream CCL14 gene. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24114] "Expressed in thymus, lung, colon, and small intestine and induced by PHA in mononuclear cells and by cytokines in monocytes, human CCL17 Gene (Intercrine Beta Family) at 16q13 encodes secreted 94-aa 10-kD (precursor) Small Inducible Cytokine A17, an immunoregulatory chemotactic factor for T lymphocytes that binds to CCR4 and CCR8 receptors and is important in inflammatory processes, in thymic T cell development, and in trafficking and activation of mature T cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24115] "Induced by glucocorticoids, PMA, IL-4, IL-13, and IL-10 and expressed in lung, lymph nodes, placenta, bone marrow, dendritic cells, and macrophages, human CCL18 Gene (Intercrine Beta Family) at 17q11.2 encodes secreted 89-aa 10-kDa (precursor) Small Inducible Cytokine A18, an immunoregulatory chemotactic cytokine for naive T cells, CD4+ and CD8+ T cells, and nonactivated lymphocytes involved in inflammatory processes s well as humoral and cell-mediated immunity. CCL18 may be involved in B cell migration into lymph node follicles. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24116] "Expressed in lymph nodes, thymus, appendix, colon, trachea, spleen, small intestine, lung, kidney, and stomach, human CCL19 Gene (Intercrine Beta Family) at 9p13 encodes secreted immunoregulatory 98-aa 11-kD (precursor) Small Inducible Cytokine A19, involved in inflammatory and immunological responses, that binds to CCR7 receptor and plays a role in thymic T cell trafficking and in T and B cell migration. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24117] "Repressed by IL-10 and induced by LPS, PMA, TNF, and INF Gamma in liver, lymph nodes, appendix, PBL, thymus, prostate, testis, small intestine, colon, and fetal lung, human CCL20 Gene (Intercrine Beta Family) at 2q33-q37 encodes 2 alternative isoforms of secreted Small Inducible Cytokine A20, a chemotactic factor for lymphocytes, neutrophils, and dendritic cells that binds CCR6 and may inhibit proliferation of myeloid progenitors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24118] "This gene encodes small Inducible cytokine A2, a member of cytokine family. It plays a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24119] "Expressed in macrophage, monocyte-derived dendritic cells, thymus, lymph node, appendix, activated monocytes, resting and activated macrophages, lung, small intestine, and spleen, human CCL22 Gene (Intercrine Beta Family) at 16q13 encodes secreted immunoregulatory 93-aa 11-kD (precursor) Small Inducible Cytokine A22, a chemotactic factor for monocytes, dendritic cells, natural killer cells, and activated T lymphocytes that binds to receptor CCR4 and may play a role in activated/effector T lymphocyte trafficking to inflammatory sites. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24120] "Expressed in lung, liver, skeletal muscle, bone marrow, placenta, pancreas, and fetal liver, human CCL23 Gene (Intercrine Beta Family) at 17q12 encodes secreted immunoregulatory Small Inducible Cytokine A23 Isoform Ckbeta8, a potent CCR1 receptor agonist and suppressor of progenitor cell colony formation with chemotactic activity for resting T lymphocytes, monocytes, and neutrophils in inflammatory processes.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24121] "Expressed by activated monocytes and activated T lymphocytes, human CCL24 Gene (Intercrine Beta Family) at 7q11.23 encodes N-glycosylated secreted immunoregulatory Small Inducible Cytokine A24 with chemotactic activity for resting T lymphocytes, neutrophils, and eosinophils in inflammatory processes that binds to CCR3 and exhibits strong suppression of hematopoietic progenitor colony formation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24122] "Expressed by dendritic cells in thymus and small intestine, CCL25 Gene (Intercrine Beta Family) at 19p13.2 encodes secreted immunoregulatory 150-aa 17-kD (precursor) Small Inducible Cytokine A25, a CCR9 receptor agonist and chemotactic for thymocytes, activated macrophages, THP-1 cells, and dendritics cells in inflammatory processes. Two alternatively spliced variants encode antagonist isoforms. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24123] "Ubiquitously expressed human CCL26 Gene (Intercrine Beta Family) at 7q11.23 encodes secreted monomeric immunoregulatory 94-aa 11-kD (precursor) Small Inducible Cytokine A26, an activator of receptor CCR3 and chemotactic for eosinophils and basophils in inflammatory processes. CCL26 may contribute to eosinophil accumulation in atopic diseases. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24124] "Expressed in testis, thymus, placenta, ovary, and skin, human CCL27 Gene (Intercrine Beta Family) at 9p13 encodes immunoregulatory 112-aa 12.6-kD (precursor) Small Inducible Cytokine A27, a chemotactic factor that binds to CCR10 and mediates homing of memory T lymphocytes to cutaneous sites in inflammatory processes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24125] "Macrophage Inflammatory Protein-1 is a monokine involved in the acute inflammatory recruitment and activation of polymorphonuclear leukocytes.  There are two protein components of MIP1, alpha and beta. MIP-1 alpha has been identified as an early G0/G1 switch gene in blood mononuclear cells.  RANTES, MIP-1 alpha, and MIP-1 beta are major HIV-suppressive factors produced by CD8-positive T-cells.  (from OMIM 182283 and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24126] "The CCL3L1 gene encodes Chemokine (C-C Motif) Ligand 3-Like 1, which belongs to an intercrine beta family. This signaling cytokine attracts and activates leukocytes, and has an anti-HIV-1 activity. It is implicated in cell cycle and signal transduction. (from http://www.dsi.univ-paris5.fr/genatlas/fiche.php?n=2076)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24127] "Induced rapidly after T-cell (phytohemagglutinin, mitogens), B-cell, and monocyte (lipopolysaccharide) activation, human CCL4 Gene (Intercrine Beta Family) encodes secreted homodimeric chemotactic Small Inducible Cytokine A4, which binds to CCR5 and CCR8 in inflammatory processes. Separated by 14-kb, the head-to-head MIP-1-alpha and MIP-1-beta genes (two copies each) demonstrate parallel regulation and encode proteins with 55% sequence similarity. RANTES, MIP-1-alpha, and MIP-1-beta are major HIV-suppressive factors produced by CD8+ T cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                          
[24128] "This gene encodes a small inducible cytokine A5 which is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24129] "The CCL7 gene encodes Small Inducible Cytokine A7, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24130] "This gene encodes a small inducible cytokine A8 which displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24131] "Induced by Interferon Gamma, human CXCL10 Gene (Intercrine Alpha/Chemokine CXC Family) at 4q21 encodes secreted 98-aa 11-kD (precursor) Small Inducible Cytokine B10, a chemotactic chemokine ligand for receptor CXCR3 that causes stimulation of monocyte, natural killer cell, and T-cell migration, and modulation of adhesion molecule expression. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24132] "Induced by INF gamma and INF beta in leukocytes, pancreas, liver, astrocytes, thymus, spleen, lung, placenta, prostate, small intestine, and keratinocytes, 4-exon human CXCL11 Gene (Intercrine Alpha/Chemokine CXC Family) at 4q21.2 encodes secreted 94-aa 10-kD (precursor) Small Inducible Cytokine B11, a chemotactic ligand for 7-transmembrane, G protein-coupled receptor CXCR3 that regulates activated T cell response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24133] "Expressed in liver, spleen, lymph node, Peyer's patches, appendix, stomach, salivary gland, mammary gland, and fetal spleen, human CXCL13 Gene (Intercrine Alpha/Chemokine CXC Family) at 4q21 encodes secreted 109-aa 13-kD (precursor) Small Inducible Cytokine B13, which binds to BLR1/CXCR5 and promotes migration and chemotaxis of B lymphocytes expressing BLR-1. It may function in B lymphocyte homing to follicles. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24134] "Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas, human CXCL14 Gene (Intercrine Alpha/Chemokine CXC Family) at 5q31 encodes secreted immunoregulatory 99-aa 12-kD (precursor) Small Inducible Cytokine B14, chemotactic for monocytes and likely involved in monocyte-derived macrophage homeostasis.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24135] "Encodes Epithelial Neutrophil Activating Peptide 78, a 78 amino acid member of the CXC family of chemokines that is produced and secreted upon stimulation by interleukin 1 (IL1B) or tumor necrosis factor alpha.  Stimulates chemotactic migration of neutrophils, monocytes, lymphocytes, and fibroblasts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24136] "Human CXCL6 Gene (Intercrine Alpha/Chemokine CXC Family) at 4q21 encodes secreted 114-aa 12-kD (precursor) Small Inducible Cytokine B6, a potent inflammatory mediator and chemotactic factor for neutrophilic granulocytes that regulates leukocyte trafficking through interactions with a subset of 7-transmembrane, G protein-coupled receptors CXCR1 and CXCR2 and activates gelatinase B (MMP9) release from granulocytes. Human and bovine GCP2 are 67% identical at the amino acid level. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24137] "Expressed (0.8-kb mRNA) in activated CD8+ T cells, in spleen, thymus, small intestine, lung, prostate, and ovary, 3-exon human XCL1 Gene (Intercrine Gamma Family) encodes 114-aa 12.5-kDa (precursor) secreted Small Inducible Cytokine C1, similar to CCL8 and CCL3, but lacking the first and third cysteines of CC and CXC chemokines. XCL1 differs from XCL2 (separate gene) by only 2 amino acids; XCL1 encodes Asp7, Lys8 (mature protein) instead of His, Arg as in XCL2. XCL1 is chemotactic for CD4+ and CD8+ T cells, but not for monocytes or neutrophils, and induces increased intracellular calcium in peripheral lymphocytes; XCL1 induces migration of cells expressing XCR1. Small (8-14 kD), mostly basic, chemokines interact with 7-transmembrane G protein-coupled receptors and regulate cell trafficking of leukocytes, as well as development, homeostasis, and immune system function. (NCI)"                                                                             
[24138] "Expressed, like XCL1, in activated T cells (low levels in unstimulated cells), 3-exon human XCL2 Gene (Intercrine Gamma Family) encodes 114-aa 12.5-kDa (precursor) secreted Chemokine (C Motif) Ligand 2, most homologous to CCL8 and CCL3 chemokines, but lacking the first and third cysteines characteristic of CC and CXC chemokines and chemotactic for lymphocytes, but not for monocytes or neutrophils. XCL2 differs from XCL1 (a separate gene product) by only 2 amino acids; XCL2 encodes His7 and Arg8 (mature protein) instead of Asp and Lys as in XCL1. XCL2 induces migration of cells expressing XCR1. Small (8-14 kD), mostly basic, chemokines interact with 7-transmembrane G protein-coupled receptors and regulate cell trafficking of leukocytes, as well as development, homeostasis, and immune system function. (NCI)"                                                                                                                                                   
[24139] "This gene encodes small inducible cytokine D1 that is the first member of a fourth branch of the chemokine superfamily. The expression of this cytokine in microglia, endothelial and fibroblastic cells is upregulated by inflammatory signals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24140] "The 10-kb human CXCL12 Gene (Intercrine Alpha/Chemokine CXC Family) at 10q11.1 encodes alternatively spliced alpha and beta isoforms of secreted 93-aa 11-kD (precursor) Stromal Cell-Derived Factor 1, a chemoattractant ligand for CXCR4 on T-lymphocytes and monocytes. The beta form contains additional sequence from exon 4. SDF1 is cleaved of an N-terminal tetrapeptide by MMP2 and loses CXCR4 affinity. Human and mouse protein sequences are nearly 92% identical. SDF1 induces intracellular actin polymerization in lymphocytes and may regulate immune surveillance and extravasation of lymphocytes and monocytes rather than in inflammation. With CD4, SDF1 is a coreceptor on CD4+ lymphocytes for HIV-1. (NCI)"                                                                                                                                                                                                                                                                 
[24141] "This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24142] "Human SEMA3E Gene (Semaphorin Family) at 7q21.11 encodes 775-aa 89-kDa (precursor) secreted Semaphorin 3E, a signaling protein containing a Sema domain and an Ig-like C2-type domain. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24143] "Expressed in pancreas and adipose tissues, 8-exon human SERPINI2 Gene (PAI-1 Serpin Family) at 3q26.1-q26.2 encodes 405-aa 46-kDa (precursor) secreted Protease Inhibitor 14, containing a signal peptide, 3 cysteine residues, and 3 potential N-glycosylation sites. SERPINI2 may have a role in a growth-control, possibly growth-suppression. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24144] "Expressed in all tissues and responsive to serum factors, contact inhibition, or differentiation, human SET Gene (NAP Family) at 9q34 encodes 277-aa 32-kDa nuclear Phosphatase 2A Inhibitor I2PP2A, a specific inhibitor of PP2A that may be involved in intracellular signaling after ligand activation of HLA class II molecules. Serine phosphorylated SET has a long acidic C-terminus and SET domain. Located in an ER-associated complex containing pp32, HMG2, and APE1, SET is a specific inhibitor of GZMA-activated DNase/nucleoside diphosphate kinase (GAAD/NM23H1), which mediates GZMA-induced caspase-independent apoptosis characterized by single-stranded DNA nicks. GZMA cleavage of SET releases NM23H1 from bound inhibition to SET and results in SET degradation, NM23H1 translocation to the nucleus, and NM23H1 nicking of DNA. (NCI)"                                                                                                                                    
[24145] "Widely expressed (high in testis) human SETDB1 Gene (Suvar3-9 Family) at 1q21 encodes 2 alternative isoforms of 1291-aa 143-kDa nuclear Histone H3-K9 Methyltransferase 4. Excluded from nucleoli and condensed chromatin, SETDB1 methylates histone H3 Lys-9 in epigenetic transcriptional repression that recruits HP1 proteins to methylated histones. SETDB1 contains an MBD domain, a pre-SET, a SET, and a post-SET domain, and 2 Tudor domains; pre-SET, SET and post-SET are required for methyltransferase activity. Isoform 2 lacks all methyltransferase domains. The conserved SET domain is implicated in transcriptional modulation of active or repressed chromatin through remodeling. Targeted to histone by TRIM28/TIF1B, SETDB1 contributes to euchromatic gene silencing by KRAB zinc-finger proteins and may interact with ERG. (NCI)"                                                                                                                                         
[24146] "The 14-3-3 sigma gene encodes a putative cytoplasmic, p53-regulated homodimeric inhibitor of G2/M progression that is over expressed in squamous cell carcinoma of the head and neck.  The gene is a member of a large 14-3-3 gene family. The product is also called stratifin or HME1."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24147] "Human SFRP4 Gene (SFRP Family) at 7p14.1 encodes Secreted Frizzled-Related Protein 4, a soluble modulator of WNT signaling that contains an N-terminal signal peptide, no transmembrane domain, a hydrophilic C terminus, and a Cys-rich domain homologous to the putative WNT-binding site of Frizzled proteins. Involved in cytoskeletal regulation, apoptosis, and proliferation, WNT-mediated simulation of 'Frizzled' receptors can activate beta-catenin, MAPK kinase, and G protein pathways. Bound to WNTs or frizzled receptors, secreted frizzled-related proteins antagonize WNT/frizzled pathways. SFRP4 may inhibit WNT8-mediated development of secondary axes. (NCI)"                                                                                                                                                                                                                                                                                                                
[24148] "Human SH2B Gene at 16p12.1 encodes SH2-B Homolog, similar to rat (FceRI gamma-chain interacting protein) SH2-B and may be involved in hormone and cytokine cellular signaling pathways. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24149] "Expressed in placenta, pancreas, kidney, lung, fetal kidney, and fetal lung as a 2.7-kb transcript, human SH2D3A Gene at 19p13.3 encodes 76-aa 64-kD adaptor protein SH2 Domain Containing Protein 3A, containing a potential SH3 interaction domain. Insulin or EGF induce rapid tyrosine phosphorylation of SH2D3A and increased association with p130-Cas. SH2D3A appears to mediate activation of stress-activated JNK1, but not MAPK1. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24150] "Expressed in a variety of tissues as 3.2- and 3.8-kb transcripts, human SH2D3C Gene at 9q34.13 encodes 698-aa SH2 Domain Containing Protein 3C, a putative adaptor protein containing a potential SH3 interaction domain that may link integrin and tyrosine kinase receptors to the JNK/SAPK pathway. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24151] "Widely expressed as 3 isoforms, p66SHC, p52SHC and p46SHC, by alternative initiation, human SHC1 Gene at 1q21 encodes 583-aa 63-kDa (precursor) cytoplasmic SH2 Domain Containing Transforming Protein 1, a growth factor receptor adaptor protein containing collagen homology, SH2, SH3, and PID/PTB domains involved in many RAS mitogenic signal transduction pathways. p46, p52, and p66 differ in the N terminals. The PID domain specifically and rapidly binds to the Asn-Pro-Xaa-Tyr(P) motif of tyrosine-phosphorylated proteins. SHC1 is phosphorylated by activated growth factor receptor tyrosine kinases. p66, tyrosine phosphorylated by activated growth factor receptors, complexes with GRB2, an adaptor protein for RAS exchange factor SOS. (NCI)"                                                                                                                                                                                                                             
[24152] "Expressed in the brain as a 10-kb transcript, human SHC3 Gene at 9q22.1 encodes 474-aa 52-kD and 594-aa 64-kD isoforms of Neuronal SHC, similar to SHC; nearly 70% homology in the PTB and SH2 domains. SHC3 appears involved in signaling from BDNF/TRKB to the RAS/MAPK pathway. BDNF induces tyrosine phosphorylation of SHC3 and binding to TRKB. Activated EGFR also interacts with and tyrosine-phosphorylates SHC3, inducing an association with GRB2. SHC3 and SCK mediate EGF signaling, but SHC3 has a higher affinity for TRKA and TRKB. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24153] "Expressed only during embryogenesis, human SHH Gene (Hedgehog Family) at 7q36 encodes 462-aa 50-kDa (precursor) Sonic Hedgehog Homolog, the notochord inductive signal in ventral neural tube and somite patterning and the polarizing signal for anterior-posterior limb axis patterning. The C-terminal domain displays precursor processing autoproteolytic activity that generates the soluble signaling N-portion. With transferase activity, the C-portion covalently attaches cholesterol to the new N-product C-terminus, restricting it to the cell surface and regulating distribution of protein activity throughout the embryo. SHH binds to PTC receptor, releasing constitutive SMO repression and activating target gene transcription. Defects in SHH cause HPE3. (NCI)"                                                                                                                                                                                                            
[24154] "Expressed as 2 alternative isoforms in monocytes and dendritic cells, human SIRPB1 Gene (SIRPB Family/Ig Family) at 20p13 encodes N-glycosylated 398-aa 43-kDa (precursor) type I membrane protein Signal-Regulatory Protein Beta 1, a cell surface Ig-like transmembrane receptor glycoprotein containing an IgV-type domain and 2 IgC1-type domains involved in negative regulation of receptor tyrosine kinase-coupled signaling. Unlike SIRPAs, SIRPB1 lacks a C-terminal cytoplasmic SHP2-binding domain. SIRPB1 interacts with ITAM protein TYROBP/DAP12, resulting in SYK tyrosine kinase recruitment. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                
[24155] "Widely expressed with immediate early kinetics upon serum stimulation, human SKIL Gene at 3q26 encodes alternative isoforms of SKI-Like Protein SKIL: SNON (684-aa), SNOA (415-aa), SNON2, SNOI (skeletal muscle restricted). A component of the TGFB/SMAD pathway, SNON interacts with SMAD2/3 and regulates cell growth and cell differentiation signaling. Absent TGFB, SNON binds nuclear SMAD4 and represses target gene promoter activity. APC activator CDH1 forms a complex with SNON, SMAD3, and TGFB-regulated ubiquitin ligase APC, regulating SNON degradation. TGFB activates SMAD2/3/4 nuclear translocation. SNON degradation allows SMAD2/4 to activate TGFB target genes. TGFB also induces SNON expression, which binds to SMAD complexes and shuts off TGFB signaling. (NCI)"                                                                                                                                                                                                    
[24156] "This gene encodes a DEAD box protein which a ATP-dependent RNA helices, may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene consists of 28 exons and the gene is located in the class III region of the major histocompatibility complex. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24157] "Expressed as 3 alternative isoforms, alpha (42-aa 48-kDa), beta (410-aa), and gamma (442-aa), human SKP2 Gene (F-Box Family) at 5p13 encodes S-Phase Kinase-Associated Protein 2, containing an F-box domain and 10 tandem LRR repeats. SKP2 acts as a substrate recognition component of the SCF E3 ubiquitin ligase complex, which mediates ubiquitination and proteasomal degradation of target proteins involved in cell cycle progression, signal transduction, and transcription. SKP2 interacts with CUL1, SKP1, and CKS1, and with the Cyclin A/CDK2 complex as an essential element of Cyclin A/CDK2 S-Phase Kinase. Involved in the G1/S transition, SKP2 specifically recognizes phosphorylated CDKN1B/p27KIP predominantly in S phase and interacts with S-phase p19SKP1. CDKN1B/p27KIP degradation also requires CKS1. (NCI)"                                                                                                                                                          
[24158] "Human SLC26A3 Gene (SLC26A/SulP Transporter Family) encodes 764-aa 85-kDa Chloride Anion Exchanger, a sulfate/chloride/bicarbonate transmembrane glycoprotein exchange transporter containing 1 STAS domain and localized in lower intestinal columnar epithelial apical membranes and some goblet cells. Involved in absorbtion, SLC26A3 mediates electrolyte and fluid absorption. Defects in SLC26A3 are the cause of congenital chloride diarrhea (CLD). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24159] "Broadly expressed as a 2.7-kb transcript (highest in liver, pancreas, prostate, ovary, and brain), human SLI Gene at 19p13.3 encodes 489-aa Neuronal SHC Adaptor Homolog, containing a conserved N-terminal PTB domain, a CH domain, and a conserved C-terminal SH2 domain, as well as unique proline-rich motifs that may be SH3 recognition sites. SCK and NSHC mediate EGF signaling and both bind to neurotrophic receptors TRKA and TRKB. SCK appears to specifically associate with cytoplasmic c-SRC tyrosine kinase CSK (phosphorylated by SRC), which downregulates c-SRC kinase through C-terminal tyrosine phosphorylation. (NCI)"                                                                                                                                                                                                                                                                                                                                                       
[24160] "The protein encoded by this gene appears to be 7-transmembrane G protein-coupled receptor. Seems to form a complex with PTCH, playing a role in the sonic hedgehog signaling pathway. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24161] "Serum-inducible kinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division. Highly similar to cytokine-inducible serine/threonine kinase (CNK); may be involved in the regulation of cell cycle progression (OMIM, LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24162] "Human FRS2 Gene at 12q15 encodes 508-aa 56.8-kD FGFR Signalling Adaptor, containing a myristylation sequence, a PTB domain, and 4 potential GRB2-binding sites. FGFR-mediated tyrosine-phosphorylated FRS2 binds directly to FGFR1 and to GRB2/SOS in response to FGF or NGF stimulation. FRS2 myristylation is essential for membrane localization, tyrosine phosphorylation, GRB2/SOS recruitment, and MAP kinase activation. FRS2A is threonine phosphorylated by MAPK in response to FGF insulin, EGF, and PDGF. FRS2 may function as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with MAPK and other signaling pathways essential for cell growth and differentiation.  (NCI)"                                                                                                                                                                                                         
[24163] "The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24164] "This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also interact with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                 
[24165] "Expressed as a 0.9-kb transcript, 5-exon human SRP19 Gene (SRP19 Family) at 5q21-q22 between DP1 and DP2.5 encodes 144-aa cytoplasmic Signal Recognition Particle 19kDa, with 7 C-terminal Lys interrupted by 2 Gly residues and involved in signal-recognition-particle assembly (SRP). Monomeric SRP19 mediates binding of the monomeric 54-kDa subunit and binds directly to the SRP 7SLRNA helix 6 stem-loop structure. Mediating signal recognition, translational arrest, and ER targeting by docking protein interaction, the SRP complex consists of a 7SLRNA and SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72 protein subunits. SRP9/SRP14 (Alu domain) and SRP68/SRP72 (S domain) bind to 7SLRNA as heterodimers. (NCI)"                                                                                                                                                                                                                                                                   
[24166] "Human SRPUL Gene at Xq21.33-q23 encodes Sushi-Repeat Protein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24167] "Human SSH3BP1 Gene at 10p11.2 encodes Spectrin SH3 Domain Binding Protein 1, containing similarity to homeotic proteins, several polyproline stretches, and a C terminal SH3 domain required for binding to ABL proteins. Binding SH3 domains of EPS8, SSH3BP1 adaptor protein holds EGFR substrate EPS8 in complex with SOS1, mediating RAS signal transduction to RAC (activation) by regulating RAC-specific GEF activity. Depending on its association with SSH3BP1 or RNTRE, EPS8 participates in EGFR signaling through RAC or in EGFR trafficking through RAB5. EPS8 interacts through its SH3 domain with the EGFR-regulated RAB5 GAP RNTRE, which inhibits EGFR internalization. EPS8 diversion from RAC-activation by RNTRE, results in RAC signaling attenuation. (NCI)"                                                                                                                                                                                                                 
[24168] "SSPN gene is expressed in a variety of tissues with highest levels in muscle, where alternative splice variants have been observed. In certain tumors KRAS2, SSPN, and ITPR2 are coamplified.  Part of the dystrophin-glycoprotein complex of the muscle sarcolemma.  The function of this gene is unknown. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24169] "Expressed primarily by the hypothalamic median eminence and by pancreatic delta cells, human SST Gene (Somatostatin Family) at 3q28 encodes secreted 116-aa 13-kDa (precursor) Somatostatin, an important cyclic tetradecapeptide regulator of endocrine and nervous system function. Somatostatin inhibits release of adenohypophyseal GH, thyrotropin, and corticotropin, pancreatic insulin and glucagon, gastric mucosal gastrin, intestinal mucosal secretin, and renal renin by binding to specific high-affinity cell surface G protein-coupled receptors expressed in a tissue-specific manner. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                      
[24170] "Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR1 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in jejunum and stomach. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24171] "Somatostatin binds to a group of structurally related tissue-specific high-affinity integral membrane GPCRs (family 1), coupled via G proteins to inhibition of adenylyl cyclase.  Somatostatin Receptor 3 is readily detected in brain, pituitary, and pancreatic islets.  (from OMIM 182453, SWISS-PROT P32745, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24172] "Expressed in fetal and adult brain, lung, stomach, kidney, pituitary, and adrenals as an 1,167-bp open reading frame, human SSTR4 Gene (GPCR1 Family) at 20p11.2 encodes 388-aa 42-kDa Somatostatin Receptor 4, a tissue-specific high-affinity integral membrane protein receptor for somatostatin-14 functionally coupled to adenylate cyclase inhibition by G proteins and to activation of both arachidonate release and MAP kinase cascade. Having strong sequence identity with SSTR1, SSTR2, and SSTR3, SSTR4 mediates the antiproliferative action of somatostatin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                  
[24173] "The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24174] "The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. (LocusLink)"                                                                                                                                                                                                                                                                             
[24175] "The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Three alternatively spliced transcript variants have been reported, the full length nature is not known for two of them. (LocusLink)"                                                                                                       
[24176] "The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Two alternatively spliced transcript variants encoding distinct isoforms have been described. (LocusLink)"                                                                             
[24177] "The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests an antiapoptotic function of this gene in cells. (LocusLink)"                                                                                                                        
[24178] "The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. (LocusLink)"                                                                                                                                                                                                                                                         
[24179] "Expressed as a 4-kb, and a less abundant 2-kb, mRNA in most tissues (ovary, prostate, heart, kidney, and thyroid highest), 4-exon 13-kb human STC1 Gene (Stanniocalcin Family) at 8p21-p11.2 encodes 247-aa 28-kDa (precursor) secreted Stanniocalcin 1, a homodimeric 35-kD glycoprotein hormone involved in calcium homeostasis and renal phosphate reabsorption. In kidney, expression is confined to the distal convoluted tubule and the collecting tubule. STC1 is 96% identical to mouse protein and 73% similar to fish STC. Serine phosphorylation by PKC may regulate activity. Ovarian STC may signal between thecal-interstitial cells and the corpus luteum and oocyte. (NCI)"                                                                                                                                                                                                                                                                                                         
[24180] "Widely expressed as multiple transcripts in muscle and heart (strongest), pancreas, kidney, spleen, prostate, small intestine, colon, and peripheral leucocytes, 4-exon human STC2 Gene (Stanniocalcin Family) at 5q35.2 encodes 302-aa Stanniocalcin 2, a constitutively secreted disulfide-linked homodimeric 32-kD protein that regulates calcium and phosphate homeostasis. STC2 and STC1 exon-intron boundaries are completely conserved. STC2 shares 34% identity with STC1; human and mouse proteins are nearly 88% identical. A Cys-rich N-terminal region may mediate homodimerization. STC2 function on kidney phosphate transport appears to be opposite STC1. STC2 may be serine phosphorylated by a casein kinase-2 ecto-protein. STC2 is likely phosphorylated on serine 288. Phosphorylation may regulate calcium and phosphate homeostasis activity. (NCI)"                                                                                                                         
[24181] "Expressed as multiple transcript variants that encode the same protein in testis, skeletal muscle, thymus, and spleen, human STK6 Gene (Aurora Ser/Thr Kinase Family) at 20q13.2-q13.3 encodes 403-aa 45.8-kDa Serine/Threonine Kinase 6, a phosphorylated cell cycle-regulated kinase localized on centrosomes in interphase cells and at spindle poles in mitosis. Cell cycle-regulated expression accumulates in G2/M and decrease rapidly thereafter. STK6 appears to be involved in cell cycle-regulated microtubule formation and/or stabilization of the spindle pole region during chromosome segregation in anaphase and telophase. STK6 defects are responsible for centrosome aberrations, including aneuploidy. (NCI)"                                                                                                                                                                                                                                                                  
[24182] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24183] "Human SUI1 Gene (SUI1 Family) at 17q21.2 encodes 113-aa 12.7-kDa Protein Translation Factor SUI1 Homolog, a putative negative growth regulator likely involved in translation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24184] "The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24185] "This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24186] "Human TAL2 Gene at 9q32 (33-kb from the t(7;9)(q34;q32) breakpoint specifically associated with T-ALL) encodes 108-aa 12-kDa bHLH T-Cell Acute Lymphocytic Leukemia 2 Protein, with sequence homology to TAL1 and LYL1, bHLH proteins involved in T-cell leukemogenesis. TAL2 also includes a DNA-binding domain homologous to those in TAL1 and LYL1. t(7;9)(q34;q32) results from a mistake during V(D)J recombination using a fortuitous 3-prime TAL2 recombination site and the TCRB J-beta-2 coding segment that juxtaposes TAL2 with the TCR-beta enhancer and results in TAL2 overexpression. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                         
[24187] "With highest expression of a 6-kb transcript in kidney, heart, placenta, and lung, human TAZ Gene encodes 400-aa 45-kDa Transcriptional Coactivator with PDZ-Binding Motif, containing a putative N-terminal 14-3-3 protein-binding motif, a central WW domain, and a C-terminal PDZ-binding motif and 2-stranded coiled-coil. The PDZ-binding domain localizes TAZ to discrete nuclear foci and is required for TAZ-stimulated gene transcription; it also mediates TAZ interaction with SLC9A3R2. Interaction with 14-3-3 appears to require TAZ phosphorylation on a specific serine residue; phosphorylation reduces TAZ transcriptional coactivation by inducing nuclear export through interaction with 14-3-3. TAZ shares 91% identity with mouse Taz and 45% identity with YAP. (NCI)"                                                                                                                                                                                                      
[24188] "This gene encodes a protein that is similar to I-kappa-B (IKB) kinases, which phosphorylate IKB proteins.  IKB proteins inactivate NF-kappa-B (NFKB) complex of proteins by trapping it in the cytoplasm.  Initiation of IKB proteins degredation (via ubiquitination pathway) was marked by phosphorylation on serine residues by IKB kinases, thereby allowing activation and nuclear translocation of the NFKB complex. TANK Binding Kinase 1 can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                
[24189] "Alternatively spliced human TCF3 Gene encodes E12 and E47 isoforms of 654-aa 68-kDa nuclear bHLH Transcription Factor 3. TCF3 is homologous to MYOD, MYC, 'daughterless', 'achaete-scute' and 'twist' families. As a heterodimer with tissue-specific bHLH proteins (e.g., ASH1 and TWIST2), TCF3 determines diverse cell fates during embryogenesis. TCF3 heterodimers bind DNA on CANNTG E-box motifs, such as kappa Ig gene enhancer E2 sites. TCF3 is likely phosphorylated following NGF stimulation. Crucial in dimerization and DNA binding, the bHLH motif forms 2 amphipathic helices that contain highly conserved hydrophobic residues. TCF3 is involved in B-ALL through a t(1;19)(q23;p13.3) translocation and fusion with PBX1. (NCI)"                                                                                                                                                                                                                                                
[24190] "Member of the high mobility group (HMG) family of DNA-binding proteins; activates transcription when complexed with beta-catenin (CTNNB1); contains an HMG box DNA-binding domain. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24191] "Related to TCL1A oncogene, a gene involved in the development of T-cell leukemia. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24192] "Ubiquitously expressed (highest in kidney), human TCTA Gene encodes 103-aa 11-kDa T-Cell Leukemia Translocation Altered Gene Product. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24193] "The protein encoded by this gene belongs to the Tec family, which is a subfamily of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.(LocusLink)"                                                                                                                                                                                                                                                                                                                                                                              
[24194] "Expressed predominantly in endothelia and angioblasts, human TEK Gene (TIE Family) encodes TEK Tyrosine Kinase (TIE2), a type I transmembrane protein receptor, closely related to the TIE receptor, with activating ligand ANG-1 and inhibitory ligand ANG-2. With a unique extracellular domain containing 2 Ig-like C2 domains separated by 3 EGF-like domains connected to 3 FN III-like domains, the ANG1/ANG2 receptor TEK is important in angiogenesis, endothelial cell proliferation and differentiation, and endothelial cell patterning during vascular morphogenesis. TEK may constitute a mammalian endothelial cell lineage marker. Activating defects and deficiencies in TEK are associated with venous malformations (VMCM). (NCI)"                                                                                                                                                                                                                                                
[24195] "Similar in structure to TFAP2A, 10-kb human TFAP2C Gene (AP-2 Family) at 20q13.2 contains 7 exons that encode 450-aa 49-kD AP-2 Gamma, a sequence-specific dimeric transcription co-activator that binds to 5prime-GCCNNNGGC-3prime DNA sequence in cellular enhancers of many genes involved in retinoic acid-induced neuroectodermal differentiation. The promoter contains no canonical TATA and CCAAT boxes, but has CpG islands and binding sites for OCT1 and AP2. Exon 1 is untranslated. AP-2 Gamma also suppresses expression of the C/EBP-Alpha, MCAM/MUC18, and c-MYC genes. Unlike the N-terminal activation domain, the C-terminal DNA-binding and dimerization domains of AP-2- Gamma are highly conserved with other family members. AP2-B may form homodimers or heterodimers with AP-2 family members. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                
[24196] "Expressed in heart, skeletal muscle, placenta, kidney, brain, lung, and liver by human TFDP2 Gene (E2F/DP Family), alternative isoforms alpha (446-aa, 49-kDa), beta (369-aa, 43-kDa), gamma (370-aa), and delta (385-aa, 48-kDa) of phosphorylated nuclear Transcription Factor Dp-2, in a heterodimeric complex with E2F family members, regulate genes required for G1/S cell cycle progression, S-phase progression, cell cycle regulation, DNA replication, or apoptosis. TFDP2 binds DNA cooperatively with E2F through the E2 recognition site, TTTCC/GCGC. Interact of DP/E2F with hypophosphorylated RB1, P107, and P130 inhibits the E2F transactivation domain. In mid-to-late G1, phosphorylated RB detaches from DP/E2F rendering E2F transcriptionally active. Viral oncoproteins E1A, T-antigen, and HPV E7 can sequester RB protein, releasing active DP/E2F complex. (NCI)"                                                                                                        
[24197] "Ubiquitously expressed 7-exon human TFE3 Gene (bHLH Family) encodes 743-aa 80-kDa nuclear Transcription Factor Binding to IGHM Enhancer 3, which contains an activation domain, leucine zipper, and bHLH domain and binds to the Ig heavy-chain enchancer MUE3 motif and to the USF/MLTF site. Efficient DNA binding requires dimerization with another bHLH protein. TFE3 is involved in papillary renal cell carcinoma through chromosomal translocations t(X;1)(p11.2;q21.2) which involves PRCC; t(X;1)(p11.2;p34) which involves PSF, and Inv(X)(p11.2;q12) which involves NONO.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                       
[24198] "Transforming growth factors (TGFs) are biologically active polypeptides that reversibly confer the transformed phenotype on cultured cells. Alpha-TGF shows about 40% sequence homology with epidermal growth factor and competes with EGF for binding to the EGF receptor, stimulating its phosphorylation and producing a mitogenic response (OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24199] "The TGFB1 gene at 19q13.1 encodes Transforming Growth Factor Beta 1 (TGF-Beta 1), which is a member of the TGF-beta family. This secreted multifunctional peptide controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-Beta 1 and essentially all of them have specific receptors for this peptide. TGF-Beta 1 regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. (from Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24200] "The TGFB2 gene encodes TGF-beta 2, which is a disulfide-linked homodimer belonging to the TGF-beta cytokine family that has suppressive effects on Interleukin-2-dependent T-cell growth. It may have an autocrine function in enhancing tumor growth and/or reducing immunosurveillance of tumor development. Two isoforms are produced by alternative splicing. TGF-beta 2 is expressed in a wide variety of mesenchymal tissues and in the ventral nervous system during human embryogenesis. (from OMIM 190220, Swiss-Prot P08112, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24201] "Constitutively expressed in many tissues (high in corneal epithelium) and induced by TGF-beta, human TGFBI Gene encodes highly conserved 683-aa 75-kDa (precursor) extracellular Transforming Growth Factor-Beta Induced Protein IGH3, containing an N-signal peptide, four 140-aa FAS1 domains with internal homology, and a C-RGD motif. RGD is found in many extracellular matrix proteins that modulate cell adhesion and serves as a ligand recognition sequence for several integrins. With similar structure to fasciclin I (putative neuronal cell adhesion protein) and OSF-2 (potential bone adhesion protein), TGFBI binds to types I, II, and IV collagens. A potential adhesion protein, TGFBI may play role in cell-collagen interactions, may be associated with microfibrils and the cell surface, and may be involved in endochondral bone formation. TGFBI defects cause CDGG1, CDRB, CDL1, CDL3A, and ACD. (NCI)"                                                                
[24202] "Expressed in all tissues (most in placenta), 9-exon 31-kb human TGFBR1 Gene (TGFBR Ser/Thr Family) encodes 503-aa 53-kDa (56-kDa precursor) Transforming Growth Factor Beta Receptor I, a type I transmembrane protein receptor for multifunctional cytokine TGFB1 containing a signal peptide, an extracellular Cys-rich region with an N-glycosylation site, a transmembrane region, and a cytoplasmic protein Ser/Thr kinase domain that mediates induction of cell-matrix adhesion genes and regulates cell cycle progression. TGF-beta binds either TGFBR1 or transmembrane Ser/Thr TGF-Beta II receptor, which form an active heterodimeric complex. TGFB stimulation leads to phosphorylation and activation of SMAD2 and SMAD3, which, complexed with SMAD4, accumulate in the nucleus and regulate transcription of target genes. Continuous SMAD nucleocytoplasmic shuttling during TGFB signaling monitors receptor activity. (NCI)"                                                     
[24203] "Human TGFBR3 Gene encodes 849-aa 93-kDa (precursor) Transforming Growth Factor Beta Receptor III, a membrane-bound or soluble glycoprotein heavily modified by glycosaminoglycan groups, with regions of similarity to endoglin, and containing a ZP domain. Lacking a recognizable signaling domain, TGFBR3 binds to TGF-Beta and may be a TGFBR and FGFR receptor accessory molecule; it may capture and retain TGF-Beta for presentation to signaling receptors. TGF-beta is a multifunctional cytokine that modulates cell differentiation, cell cycle progression, cellular migration, adhesion, and extracellular matrix production. TGFBR3 can also bind inhibin and function as coreceptor with ActRII; inhibin forms crosslinked complexes with TGFBR3 and ActRII. TGFBR3 also binds beta arrestin 2, which appears to trigger cytoplasmic phosphorylation by TGFBR2. (NCI)"                                                                                                               
[24204] "Specifically expressed in developing endothelial cells, human TIE Gene (TIE Tyr Kinase Family) encodes 1138-aa 125-kDa (precursor) type I transmembrane Protein Receptor Tyrosine Kinase TIE 1, containing 2 Ig-like C2-type domains, 3 fibronectin type III domains, and 3 EGF-like domains. TIE1 receptor may be involved in multiple protein-protein interactions, possibly including endothelial cell adhesion, blood clotting, and inflammation. TIE1 receptor is important in angiogenesis, particularly endothelial vascular formation. Combinatorial ANG-1 and TIE1 orphan receptor function is critical for right-side venous system development. (NCI)"                                                                                                                                                                                                                                                                                                                                   
[24205] "Ubiquitously expressed (highest in spleen, ovary, leukocytes, thymus, and small intestine) human TLR1 Gene (TLR family) encodes 786-aa 90-kDa (precursor) type I transmembrane Toll-Like Receptor 1, containing a TIR domain and 8 LRR repeats and having a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR1 binds to the TLR2 extracellular domain and cooperates with TLR2. TLR1 appears to bind MyD88 via their TIR domains, and to TRAF6, leading to NF-Kappa-B activation, cytokine secretion, and inflammatory response. (NCI)"                                                                                                                                                                                   
[24206] "Highly expressed in monocytes, bone marrow, lymph node, and spleen, human TLR2 Gene (TLR Family) encodes 784-aa 90-kDa (precursor) type I transmembrane Toll-Like Receptor 2, containing a TIR domain and 14 LRR repeats and having a fundamental role in pathogen recognition and activation of innate immunity. Sharing structural and functional similarities, TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production for effective immunity. With LY96, TLR2 mediates response to microbial lipoproteins and cell wall components. Binding LY96 and TLR6 via the extracellular domains, TLR2 recognizes MALP-2, STF, PSM, and OspA-L with TLR6. TLR2 acts via MyD88 (via their TIR domains) and TRAF6, activating NF-Kappa-B, cytokine secretion, and inflammatory response. TLR2 may promote apoptosis in response to lipoproteins. (NCI)"                                                                                       
[24207] "Expressed most in placenta, pancreas, and CD11c+ immature dendritic leukocytes, human TLR3 Gene (TLR Family) encodes 904-aa 104-kDa (precursor) type I membrane protein Toll-Like Receptor 3, containing a TIR domain and 22 LRR repeats. Likely involved in host viral defense, TLR3 recognizes viral dsRNA and has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR3 appears to act via MyD88 (TIR interaction) and TRAF6, leading to NF-Kappa-B activation and production of type I interferons. (NCI)"                                                                                                                                                                                                             
[24208] "Expressed most in placenta, spleen, and myelomonocytic leukocytes, human TLR4 Gene (TLR Family) encodes isoforms A-D of 96-kDa (precursor) type I membrane protein Toll-Like Receptor 4, containing a TIR domain and 21 LRR repeats. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. As part of the LPS receptor (with CD14 and LY96), TLR4 mediates the immune response to LPS in gram-negative bacteria. Binding to LY96 via the extracellular domain and to MyD88 and TIRAP via their TIR domains, TLR4 acts via MyD88, TIRAP, and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and the inflammatory response. TLR4 Asn-526 and Asn-575 glycosylation seems necessary for the LPS-response. (NCI)"                                                                                                       
[24209] "Highly expressed in ovary and myelomonocytic cells, human TLR5 Gene (TLR Family) encodes 858-aa 98-kDa (precursor) type I membrane protein Toll-Like Receptor 5, containing a TIR domain and 15 LRR repeats. Mediating detection of bacterial flagellin (a virulence factor), TLR5 has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. Likely bound to MyD88 via the TIR domains, TLR5 acts via MyD88 and TRAF6, leading to NF-Kappa-B activation, TNF-alpha production, and the inflammatory response. (NCI)"                                                                                                                                                                                                            
[24210] "Expressed in monocytes, CD11c+ immature dendritic cells, and dermal endothelial cells, human TLR6 Gene (TLR Family) encodes 796-aa 92-kDa (precursor) type I membrane protein Toll-Like Receptor 6, containing a TIR domain and 13 LRR repeats. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. Bound extracellularly to TLR2, TLR6 mediates cellular response to fungi and bacterial lipoproteins MALP-2, STF, PSM, and OspA-L. TLR6 acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and the inflammatory response. (NCI)"                                                                                                                                                                                                                                               
[24211] "Expressed in lung, placenta, spleen, brain, stomach, small intestine, and pre-dendritic cells, human TLR7 Gene (TLR Family) encodes 104-aa 121-kDa (precursor) type I membrane protein Toll-Like Receptor 7, containing a TIR domain and 27 LRR repeats. TLR7 has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR7 likely acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. (NCI)"                                                                                                                                                                                                                                                      
[24212] "Expressed in lung, brain, heart, liver, placenta, monocytes, peripheral leukocytes, and CD11c+ immature dendritic cells, human TLR8 Gene (TLR Family) encodes 1041-aa 120-kDa (precursor) type I membrane protein Toll-Like Receptor 8, containing a TIR domain and 24 LRR repeats. TLR8 has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR8 likely acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. (NCI)"                                                                                                                                                                                                                           
[24213] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24214] "Expressed in small intestine, prostate, colon, stomach, and salivary gland, human TMPRSS2 Gene (Peptidase S1 Family) encodes 492-aa 54-kDa (precursor) Transmembrane Protease Serine 2, containing a type II transmembrane domain, an LDL-receptor class A domain, a scavenger receptor cysteine-rich (SRCR) domain, and a protease domain. The protease domain is thought to be cleaved, activated, and secreted after autocleavage. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24215] "The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand (TNFSF11/OPGL), both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. (LocusLink)"                                                                                                                                                                                                                                                                                                                                          
[24216] "This gene has multiple transcript variants but the full length nature of some variants has not been determined. The encoded isoforms a, b, and c are related to RAD3/ERCC2, a plasma membrane Ras-related GTPase. The amplification or overexpression of these isoforms is thought to contribute to cell growth and tumor progression. It is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24217] "This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. The gene product was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. Two alternatively spliced transcript variants have been found. (LocusLink)"                                                                                                                                                                                                                                                                                                                                           
[24218] "Expressed as a 3-kb transcript in prostate, testis, ovary, small intestine, and colon, human TNK1 Gene encodes 666-aa 72-kDa Non-Receptor Tyrosine Kinase 1, containing a putative N-terminal phosphotyrosine-binding domain, a tyrosine kinase domain, a putative SH3 domain, and a Pro-rich C-terminus containing SH3-binding motifs. The kinase domain includes an ATP-binding site and many conserved tyrosine kinase features. TNK1 shares highest homology with ACK, especially in the kinase and putative SH3 domains. Like SRC and JAK family kinases, TNK1 mediates intracellular signaling downstream of receptor activation. (NCI)"                                                                                                                                                                                                                                                                                                                                                      
[24219] "Human TOLLIP Gene encodes 274-aa 30-kDa oligomeric Toll-Interacting Protein, containing a CUE domain, involved in IL-1 and Toll-like receptor signaling pathways. TOLLIP binds to TLR2 and TLR4/MD2 complex via its C-terminus. Complexed with Ser/Thr kinase IRAK in unstimulated cells, TOLLIP inhibits IRAK phosphorylation and kinase activity. Upon IL-1 signaling, TOLLIP interacts with the IL-1RacP TIR domain in the activated receptor complex (IL-1RI/IL-1RacP/MyD88), recruiting IRAK to the complex. MyD88 triggers IRAK1 autophosphorylation and IRAK1 dissociation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                           
[24220] "Expressed as a 3.3-kb transcript in several tissues, human TPD52 Gene (TPD52 Family) encodes 184-aa 20-kDa Tumor Protein D52 with a potential glycosylation site, several potential phosphorylation sites, and homology to N-type calcium channels. TPD52 forms homodimers, or heterodimers with other family members; D52, D53, and D54 share homology, including a coiled-coil domain indicative of protein-protein interactions. D52 may be involved in calcium-mediated signal transduction and cell proliferation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24221] "Expressed as a 1.5-kb transcript in kidney and skin, human TPD52L1 Gene (TPD52 Family) encodes 204-aa 22-kDa Tumor Protein D52-Like 1, with 52% identity to D52, a coiled-coil domain, and PEST domains. D52, D53, and D54 share significant homology, including a coiled-coil domain indicative of protein-protein interactions. TPD52L1 forms homodimers, or heterodimers with other family members. Like D52, TPD52L1 may be involved in calcium-mediated signal transduction and cell proliferation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24222] "Expressed as a 4.5-kb transcript in various tissues, human TRPM5 Gene encodes Transient Receptor Potential Cation Channel Subfamily M Member 5, related to the transient receptor potential (trp) protein TRPC1 and potentially involved in regulation of cellular Ca(2+) influx. The putative open reading frame encodes alternative 872-aa or 1,165-aa proteins, each with several predicted membrane-spanning domains. Mouse Trpm5 functions as a cationic channel that is gated when internal calcium stores are depleted. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24223] "Human TRRAP Gene (TRA1 Kinase Family) encodes 3859-aa 438-kDa and 3830-aa isoforms of adapter protein Transformation/Transcription Domain-Associated Protein, containing 2 TPR repeats and a component of multiprotein chromatin PCAF histone acetylase complex, TFTC-HAT complex, STAGA complex, and TIP60 HAT and BAF53 complexes, which acetylate histone H4/H2A in nucleosomes. Required for p53-, E2F1- and E2F4-mediated transcription activation, TRRAP interacts with GCN5L2, TP53, MYC, E2F1, and E2F4 transcription factors; it probably links E1A, MYC, and E2F1 to HAT complexes allowing transcription activation. Lacking kinase catalytic motifs and activity, the PI3K/PI4K domain is required for recruitment of HAT complexes and MYC-dependent transactivation. Cell cycle TRRAP is probably not required in transcription activation following histone acetylation. (NCI)"                                                                                                      
[24224] "Human TSHR Gene (FSH/LSH/TSH GPCR1 Family) encodes alternative long and short isoforms of integral membrane protein Thyroid Stimulating Hormone Receptor, a Thyrotropin receptor containing 6 LRR repeats whose activity is mediated by adenylate cyclase-activating G proteins and controls thyroid cell metabolism. TSHR also acts as a thyrostimulin receptor (GPA2+GPB5). TSHR defects cause hypothyroidism, Graves' disease, euthyroidism or papillary and follicular thyroid neoplasms. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24225] "This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24226] "This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. Alternative splicing of this gene results in two transcript variants. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24227] "Likely up-regulated by androgen and expressed in spermatogonia and spermatocytes, human TSPY Gene encodes 308-aa 35-kDa phosphorylated cytoplasmic Testis-Specific Y-Encoded Protein that may be involved in sperm differentiation and proliferation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24228] "This gene was identified as being in a region in which loss of heterozygosity has been frequently observed in breast cancers.  The protein includes 4 rpeats of the 34-amino acid tetratricopeptide repeat (TPR) motif, found in a variety of proteins and may mediate protein-protein or protein-membrane interactions. (from LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24229] "Expressed as a 4-kb mRNA in proliferating cells, human TTK Gene (Ser/Thr Kinase Family) encodes 841-aa 95-kDa TTK Protein Kinase, a likely dual-specificity kinase since it phosphorylates proteins on tyrosine as well as serine and threonine. TTK is probably associated with kinetochore or centrosome function in cell proliferation. Kinetochore-associated Mps1 kinase (Xenopus) is necessary to establish and maintain the mitotic checkpoint. Required for kinetochore recruitment and retention of active CENPE, Mps1 is necessary for Mad1 and Mad2 kinetochore association and inhibition of the Anaphase-Promoting Complex/Cyclosome. Mps1 (mouse), a Cdk2 substrate, regulates centrosome duplication jointly with Cdk2. By regulating Mps1 S phase stability, Cdk2 promotes centrosome duplication by Mps1. (NCI)"                                                                                                                                                                   
[24230] "In response to CXCL16 CXCR6 probably functions in interactions between dendritic cells and T cells and in regulating T-cell migration in the splenic red pulp. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24231] "Widely expressed (abundant in brain), human TYRO3 Gene (AXL/UFO Tyr Kinase Family) encodes 890-aa 97-kDa (precursor) type I membrane protein TYRO3 Protein Tyrosine Kinase, a putative receptor tyrosine kinase that may be involved in cell adhesion in the central nervous system and contains 2 Ig-like C2-type domains and 2 fibronectin type III domains. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24232] "Human TYROBP Gene encodes 113-aa 12-kDa (precursor) disulfide-linked homodimeric Tyr-phosphorylated TYRO Protein Tyrosine Kinase Binding Protein, a type I transmembrane polypeptide containing a cytoplasmic ITAM motif that may act as an activating signal transduction element in bone modeling, brain myelination, and inflammation. TYROBP associates with KIR family membrane glycoproteins without a cytoplasmic ITIM; KIR/TYROBP complexes promote cellular activation. TYROBP interacts with SIRPB1 and may bind TCR zeta chain-associated ZAP-70 kinase and SYK tyrosine kinase. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                  
[24233] "Human UBE2D2 Gene (E2 Ubiquitin-Conjugating Enzyme Family) encodes 147-aa 16.7-kDa Ubiquitin-Conjugating Enzyme E2D 2, which targets selective degradation of short-lived and abnormal proteins, such as E6/E6-AP-induced p53 ubiquitination, through covalent attachment of ubiquitin, the second step of ubiquitin conjugation. UBE2D2 interacts with the SCF/E3 ubiquitin ligase complex. Ubiquitination involves E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24234] "Human UNC13 Gene encodes 1591-aa UNC-13 Homolog B, containing 3 C2 domains, a C1 DAG-binding domain, and highly conserved N- and C-terminal similarity to rat Munc13 homologues. UNC13 is a putative DAG receptor and may act in a PKC-independent DAG-activated apoptosis pathway. UNC13 also appears to be a presynaptic protein that promotes synaptic vesicle priming by acting through syntaxin. Post-docking synaptic vesicle exocytosis priming requires SNARE complex formation. The default closed syntaxin configuration is incompatible with SNARE formation; the N-terminus binds the SNARE motif and occludes SNARE protein interactions. UNC13 binding to the syntaxin N-terminus may promote an open syntaxin configuration and prime synaptic vesicles for fusion. (NCI)"                                                                                                                                                                                                           
[24235] "Some evidence suggests that the human Ubiquitin Specific Protease 6 Gene locus (C19 Peptidase Family) at 17q11 may be part of three discontinuous elements originating 5-prime to 3-prime on chromosomes 5, 18, and 17. RNA transcripts are detected in a variety of cancer cells regardless of tissue origin, but not in normal cells. An 8 kb transcript possesses a long noncoding region and a translatable region with two open reading frames. The 5-prime ORF encodes a 786-amino acid hydrophilic protein with two charge clusters, suggesting nucleic acid-binding properties. Ubiquitin Specific Protease 6 appears to have ATP-independent isopeptidase activity, cleaving at the carboxyl terminus of ubiquitin.  (Omim, Swiss-Prot, LocusLink and NCI)"                                                                                                                                                                                                                                
[24236] "Related to TRE2 oncogene, human Ubiquitin Specific Protease 8 Gene (C19 Peptidase Family) at 15q15.2 encodes Ubiquitin Specific Protease 8, a deubiquitinating enzyme that cleaves at the carboxyl terminus of ubiquitin. In chronic myeloproliferative disorder, an oncogenic fusion of the 5-prime end of p85-beta occurs with the 3-prime end of USP8.  (Omim, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24237] "Human VAV3 Oncogene (VAV Family) at 1p13.2 encodes an 847-amino acid VAV-3 Protein with similarity to VAV1 and VAV2 and exhibits variable expression of a 5 kb transcript in peripheral blood lymphocytes, spleen, brain, thymus, heart, kidney, liver, placenta, and lung. Alpha and beta isoforms are produced by alternative splicing. VAV3 contains DBL and pleckstrin homology domains, a calponin homology region, an acidic motif, a DAG binding domain, two SH3 regions, and a SH2 domain. Protein encoded by splice variant VAV3.1 contains only the C-terminal SH3-SH2-SH3 region. Regulating the actin cytoskeleton and transcription, VAV3 acts as a GEF on RHOA, RHOG, and RAC1. VAV1, VAV2, and VAV3 respond to similar cell surface receptor tyrosine kinases. VAV3 is rapidly phosphorylated on TCR or EGFR activation. VAV1 and VAV3 enhance NFKB-dependent transcription. Integrin-induced phosphorylation requires SYK.  (Omim, Swiss-Prot, LocusLink, and NCI)"                 
[24238] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24239] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24240] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24241] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24242] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24243] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24244] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24245] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24246] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24247] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24248] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24249] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24250] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24251] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24252] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24253] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24254] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24255] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24256] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24257] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24258] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24259] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24261] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24262] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24263] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24264] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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[24431] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24432] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24433] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24434] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24435] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24436] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24437] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24438] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24439] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24440] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24441] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24442] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24443] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24444] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24445] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24446] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24447] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24448] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24449] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24450] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24451] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24452] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24453] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24454] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24455] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24456] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24457] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24458] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24459] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24460] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24461] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24462] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24463] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24464] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24465] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24466] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24467] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24468] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24469] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24470] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24471] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24472] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24473] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24474] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24475] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24476] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24477] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24478] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24479] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24480] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24481] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24482] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24483] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24484] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24485] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24486] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24487] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24488] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24489] "A period or stage in life, usually stated in years since birth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24490] "A natural recurring desire for food. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24491] "Autopsy; an examination and dissection of a dead body to determine cause of death or the changes produced by disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24492] "Axis; a straight line through a body or figure that satisfies certain conditions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24493] "The event of being born."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24494] "A measure of the 2-dimensional exent of the body surface."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24495] "A pill in the form of a small rounded soluble container with medicine inside."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24496] "Carcinoembryonic antigen. A substance that is sometimes found in an increased amount in the blood of people with certain cancers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24497] "City; a large and densely populated urban area."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24498] "Classification; the grouping of things into classes or categories."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24499] "A system of numbered categories for representation of data."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24500] "A Coombs test is performed to detect the presence of antibodies against red blood cells.  It can either be indirect, measuring the presence of antibodies to red blood cells in the blood, or direct, measuring the presence of antibodies on the surface of red blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24501] "A particular day specified as the time something has, or will, happen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24502] "Daughter; a female human offspring."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24503] "In healthcare, discharge represents the end point of an inpatient hospital contact which consists of one or several days of care. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24504] "The space between two objects or points."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24505] "Donor; someone who gives blood or tissue or an organ to be used in another person."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24506] "A method of achieving something. (from Cambridge Advanced Learner's Dictionary - online)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24507] "E-mail is short for \"electronic mail\" and refers to composing, sending, and receiving messages over electronic communication systems. Most e-mail systems use the Internet."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24508] "The act of determining if a subject is suitable for enrollment in a study according specific protocol criteria and procedures."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24509] "Employment; the occupation for which you are paid."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24510] "Family; a domestic group, or a number of domestic groups linked through descent (demonstrated or stipulated) from a common ancestor, marriage, or adoption."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24511] "Father; a male parent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24512] "Filed; placed in a file; record in a public office or in a court of law."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24513] "Projection; a prediction made by extrapolating from past observations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24514] "The external sex organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24515] "Health; the general condition of body and mind."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24516] "Hospitalization; the condition of being treated as a patient in a hospital."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24517] "An event, entity or condition that typically characterizes a prescribed environment or situation. Indicators determine or aid in determining whether or not certain stated circumstances exist or criteria are satisfied. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24518] "Industry; the people or companies engaged in a particular kind of commercial enterprise; the organized action of making of goods and services for sale."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24519] "Inpatient; a patient who is residing in the hospital where he is being treated."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24520] "A family of homotetrameric cytoplasmic enzymes involved in the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24521] "Laterality; having to do with the use or development of one side of the body versus the other."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24522] "High density lipoproteins are the smallest and densest lipoproteins, and contain a high proportion of protein. They are synthesized in the liver as empty proteins and they pick up cholesterol and increase in size as they circulate through the bloodstream.  Because HDL can remove cholesterol from the arteries, and transport it back to the liver for excretion, they are seen as \"good\" lipoproteins. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24523] "Low-density lipoprotein (LDL) is a lipoprotein that carries cholesterol around the body, for use by various cells.  LDL transports cholesterol to the arteries and increased levels are associated with atherosclerosis, and thus myocardial infarctions and strokes. This is why cholesterol inside LDL lipoproteins is called bad cholesterol. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24524] "A demographic parameter indicating a person's status with respect to marriage, divorce, widowhood, singleness, etc. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24525] "Mother; a female parent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24526] "Person; a human being."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24527] "A language unit by which a person or thing is known."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24528] "Occupation; the principal activity that a person does to earn money."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24529] "Compliance; acting according to certain accepted standards."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24530] "The force applied to a unit area of surface."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24531] "The allocation of individuals to groups, e.g., for experimental and control regimens, by chance. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24532] "Recommendation; advice telling someone what the best thing to do is."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24533] "Record; anything, e.g. a document, providing permanent evidence of or information about past events."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24534] "Role; the action or activity assigned to or required or expected of a person or group."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24535] "The individual as the object of his own reflective consciousness."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24536] "Sensitivity; the ability to respond to physical stimuli or to register small physical amounts or differences."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24537] "Activity measured as a test of liver function, 46/47-kDa homodimeric human Aspartate Aminotransferases (Class-I Pyridoxal-Phosphate-Dependent Aminotransferase Family) are pyridoxal phosphate-dependent enzymes involved in amino acid metabolism and in the urea and tricarboxylic acid cycles. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24538] "The region of the body between the neck and the upper arm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24539] "Sibling; a person's brother or sister."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24540] "Son; a male human offspring."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24541] "Temperature; the degree of hotness or coldness of a body or environment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24542] "Time is the continuum of experience in which events pass from the future through the present to the past."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24543] "The vertical force exerted by a mass as a result of gravity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24544] "Measurement; the size or magnitude of something."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24545] "Fax; short for facsimile; telecommunications technology used to transfer copies of documents, especially those using affordable devices operating over the telephone network; used to refer both to the activity and the resulting document."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24546] "A schedule is an ordered list of times at which things are planned to occur."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24547] "An endpoint is a place of termination or completion; in a clinical trial this may be a primary or secondary outcome variable used to judge the effectiveness of a treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24548] "Baseline; an imaginary standard by which things are measured or compared."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24549] "Evaluation; the act of placing value on something."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24550] "Karyotype; the appearance of the chromosomal makeup of a somatic cell in an individual or species, including the number and arrangement and size and structure of the chromosomes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24551] "A diaphragm or system of diaphragms made of an absorbing material, designed to define and restrict the dimensions and direction of a beam of radiation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24552] "Having determined the value, significance, or extent of."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24553] "A particular course of action intended to achieve a result."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24554] "The preservation and hardening of a tissue sample to retain as nearly as possible the same relations they had in the living body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24555] "Incision into or through the sternum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24556] "Tomogram; a radiograph obtained by tomography."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24557] "Bronchial; of, or pertaining to, the bronchus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24558] "Pleural; of, or pertaining to, the pleura."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24559] "By or having to do with the rectum.  The rectum is the last 6 inches of the large intestine and ends at the anus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24560] "Renal; of, or pertaining to, the kidney."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24561] "Mesenteric; of, or relating to, or located in a mesentery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24562] "High; greater than normal in degree or intensity or amount."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24563] "Right; being or located on or directed toward the side of the body to the east when facing north."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24564] "Left; being or located on or directed toward the side of the body to the west when facing north."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24565] "Lateral; situated at or extending to the side."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24566] "Anterior; denoting the front surface of the body; often used to indicate the position of one structure relative to another."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24567] "Medial; toward the middle or inside (as opposed to lateral)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24568] "Peripheral; on or near an edge or constituting an outer boundary; the outer area."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24569] "Internal; happening or arising or located within some limits, or especially, within some surface."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24570] "Superior; in anatomy indicating higher than a given reference point."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24571] "In medicine, refers to a part of the body that is closer to the center of the body than another part. For example, the knee is proximal to the toes. The opposite is distal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24572] "Distal; situated farthest from a point of attachment or origin, as of a limb or bone; or directed away from the midline or mesial plane of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24573] "Segmental; having naturally dividable parts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24574] "Affecting cells on the surface.  Not invasive."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24575] "Deep; extending relatively far inward."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24576] "Horizontal; parallel to or in the plane of the horizon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24577] "Longitudinal; running lengthwise."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24578] "Vertical; upright in position or posture."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24579] "Area; the extent of a 2-dimensional surface enclosed within a boundary."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24580] "Surface; the extended two-dimensional outer boundary of a three-dimensional object."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24581] "Positive; involving advantage or good."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24582] "Negative; involving disadvantage or harm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24583] "Long; of relatively great or greater than average spatial extension or temporal duration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24584] "Short; having little (physical) length or seeming to be limited in (temporal) duration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24585] "Complete; having every necessary or normal part or component or step; or having come or been brought to a conclusion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24586] "Occurring first in time or sequence; original. (American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24587] "Microscopic; too small to be seen except under a microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24588] "Multifocal; arising from or pertaining to many locations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24589] "Progressive; advancing in extent or severity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24590] "Soft; lacking in hardness relatively or comparatively."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24591] "Quantity; how much there is of something that you can measure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24592] "Phase; any distinct time period in a sequence of events"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24593] "Most; greatest in amount, extent, or degree."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24594] "Mixed; involving or composed of different kinds."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24595] "Third; following the second position in an ordering or series."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24596] "Medical; relating to the study or practice of medicine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24597] "(noor-uh-LOJ-ik) Having to do with nerves or the nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24598] "Prognostic; having value for making predictions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24599] "A ridge or ridge-like structure.  In humans it usually refers to the trachea.  The carina of trachea is part of the lowest tracheal cartilage which is placed between the orifices of the two bronchi."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24600] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24601] "Having to do with the intestines."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24602] "Lymphatic; of, or relating to, or produced by lymph."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24603] "The region below the clavicle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24604] "Having to do with symptoms, which are signs of a condition or disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24605] "Extension; an addition to the length of something."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24606] "Painful; causing physical or psychological misery, pain or distress."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24607] "Painless; not causing physical or psychological misery, pain or distress."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24608] "Residence; the place where a person lives."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24609] "Existing in fact; real. (from American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24610] "Occurrence; an instance of something happening."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24611] "Neural Cell Adhesion Molecule is a membrane-bound glycoprotein member of the Ig superfamily that binds to a variety of other cell adhesion proteins involved in diverse contact-mediated interactions.  NCAM appears on early embryonic cells and is important in the formation of cell collectives at sites of morphogenesis.  Later it is found on differentiated neurons, astrocytes, oligodendrocytes, and myotubes and mediates neuronal adhesion, guidance, and differentiation.  NCAM plays a role in cell-cell and cell-matrix adhesion through homophilic and heterophilic binding.  The invertebrate cell adhesion molecules fasciclin II (grasshoppers and Drosophila) and apCAM (Aplysia) are related to NCAM and can mediate homophilic cell aggregation.  Four main isoforms exist, including CD56, but many variants result from alternative splicing and post-translational modifications.  (from OMIM 116930 and NCI)"                                                             
[24612] "Therapeutic; relating to or involved in therapy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24613] "Fluid; a continuous amorphous substance that tends to flow and to conform to the outline of its container: a liquid or a gas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24614] "Onset; the beginning or early stages."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24615] "Recent; near to or not long before the present."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24616] "Associated; joined in some kind of relationship."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24617] "Within; on the inside; contained in."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24618] "Quality; a degree or grade of excellence or worth; an essential and distinguishing attribute of something or someone."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24619] "Type; a subdivision of a particular kind of thing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24620] "Diameter; the length of a straight line passing through the center of a circle and connecting two points on the circumference."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24621] "Necrotic; relating to or affected by necrosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24622] "Rod-shaped structures of uncertain nature in the cytoplasm of immature myeloid cells, especially myeloblasts, in acute myelocytic leukemia; may be an abnormal form of lysosomes; they contain peroxidase and acid phosphatase, and stain red by azure-eosin stains. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24623] "An abnormal large leukocyte found in the blood in hairy cell leukemia; it has numerous irregular cytoplasmic villi that give it a flagellated or hairy appearance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24624] "Brother; a male sibling."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24625] "Having been legally made a member of a family."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24626] "Venous; of, or pertaining to, or contained in, or performing the function of the veins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24627] "Cardiovascular; pertaining to the heart or blood vessels."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24628] "Activity measured as a test of liver function, human Glutamic-Pyruvate Transaminases (Alanine Aminotransferase Family) are pyridoxal phosphate-dependent enzymes involved in cellular nitrogen metabolism, amino acid metabolism, and liver gluconeogenesis. Glutamic Pyruvic Transaminases mediate conversion of major intermediate metabolites, catalyzing reversible transamination between alanine and alpha-ketoglutarate to form pyruvate and glutamate. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24629] "Test; any standardized procedure for determining the presence, quality, or truth of something."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24630] "Mobile; moving or capable of moving readily."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24631] "Birth Date; the calendar date on which a person was born."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24632] "Notification; informing by words."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24633] "Systolic Pressure; the blood pressure during the contraction of the left ventricle of the heart."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24634] "Diastolic Pressure; the blood pressure after the contraction of the heart while the chambers of the heart refill with blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24635] "Any laboratory procedure for growing microorganisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24636] "The time for Earth to make a complete rotation on its axis; ordinarily divided into twenty-four hours."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24637] "Granulomatous; relating to or characterized by granulomas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24638] "Having many centers. A multicentric cancer consists of a primary tumour with satellites of cancerous growth in surrounding tissues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24639] "Total; constituting the full quantity or extent; complete."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24640] "An appraisal or evaluation of a patient's condition by a physician or registered nurse, based on clinical and laboratory data, medical history, and the patient's account of symptoms.  2. The process by which a patient's condition is appraised or evaluated. (Taber's)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24641] "One of the two lateral margins or surfaces of a body, midway between the front and back."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24642] "Contralateral; on or relating to the opposite side (of the body)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24643] "Having to do with the same side of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24644] "Lower; the bottom one of two."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24645] "Mediastinal; related to the mediastinum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24646] "By or having to do with the mouth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24647] "Parietal; of, or relating to, or associated with the parietal bones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24648] "Having to do with the peritoneum (the tissue that lines the abdominal wall and covers most of the organs in the abdomen)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24649] "Radial; arranged like rays or radii; radiating from a common center."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24650] "Having to do with the viscera, which are the soft internal organs of the body, including the lungs, the heart, and the organs of the digestive, excretory, reproductive, and circulatory systems."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24651] "Regions near to the aorta."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24652] "Regions near to the trachea."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24653] "Subaortic; below the aorta."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24654] "Place; the particular portion of space occupied by a physical object."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24655] "An action plan for a clinical trial.  The plan states what the study will do, how, and why.  It explains how many people will be in it, who is eligible to participate, what study agents or other interventions they will be given, what tests they will receive and how often, and what information will be gathered."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24656] "Distant; far apart in space, time, or relevance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24657] "Long-Term; involving or being in effect for a long time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24658] "Nodal; of or pertaining to a node, any bulge or swelling of an anatomical structure or part."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24659] "Viable; capable of life or normal growth and development."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24660] "A flat rectangular piece of glass on which specimens can be mounted for microscopic study."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24661] "Whole; including all components without exception; being one unit or constituting the full amount or extent or duration; complete."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24662] "Core; the center of an object; indispensable"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24663] "Unrelated; not connected or associated e.g. by kinship."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24664] "Supraclavicular; positioned above the clavicle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24665] "Duration; the period of time during which something continues."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24666] "Progression; advancement in extent or severity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24667] "The range, magnitude, or distance over which a thing spans an interval of distance, space, or time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24668] "Depth; extent downward or inward."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24669] "Length; the linear extent in space from one end to the other."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24670] "Volume; the amount of 3-dimensional space occupied by an object."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24671] "Pattern; anything characterized by repetition."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24672] "Number; a concept of quantity derived from zero and units; a numeral or string of numerals that is used for identification."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24673] "Score; a number or letter indicating quality."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24674] "Position; the particular portion of space occupied by a physical object."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24675] "Use; put into service; make work or employ (something) for a particular purpose or for its inherent or natural purpose."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24676] "Location; a point or extent in space."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24677] "Having to do with the abdomen, which is the part of the body between the chest and the hips that contains the pancreas, stomach, intestines, liver, gallbladder, and other organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24678] "The means by which an effect is obtained."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24679] "Regions near to the esophagus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24680] "Width; the extent of something from side to side."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24681] "Class; a collection of things sharing a common attribute."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24682] "Height; the vertical dimension of extension; distance from the base of something to the top."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24683] "Having to do with muscles, bones, and cartilage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24684] "Polypectomy; surgical removal of a polyp."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24685] "Genitourinary; of or related to the genital and urinary organs or their functions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24686] "Reconstruction; surgical restoration of function or form of a part."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24687] "A system, commonly called the INR, established by the World Health Organization (WHO) and the International Committee on Thrombosis and Hemostasis for reporting the results of blood coagulation (clotting) tests. All results are standardized using the international sensitivity index (ISI) for the particular thromboplastin reagent and instrument combination utilized to perform the test; the ratio of a patient's clotting time to the lab's mean reference value is normalized against the ISI. (from medterms.com and medicine.ucsf.edu)"                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24688] "Inferior; in anatomy indicating lower than a given reference point."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24689] "The Academic Degree is an award conferred by a college, university, or other postsecondary education institution as official recognition for the successful completion of a program of studies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24690] "Upper; higher in place or position; the topmost one of two."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24691] "Documented; furnished with or supported by documents."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24692] "Registrar; someone responsible for keeping records."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24693] "Attribution; assigning to a cause or source."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24694] "Expectancy; something expected (as on the basis of a norm)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24695] "Mutant; refers to an organism, population, gene, or chromosome, etc. which differs from the corresponding wild type by one or more mutations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24696] "Performance; process or manner of functioning or operating."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24697] "Success; an event that accomplishes its intended purpose."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24698] "Having to do with nerves or the nervous system, including the brain and the spinal cord."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24699] "One or more characters used to identify, name, or characterize the nature, properties, or contents of a thing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24700] "Description; a statement that represents something in words."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24701] "Closure; refers to the closing of a study to enrollment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24702] "The final result of a determination of the value, significance, or extent of."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24703] "Member; one of the persons who compose a social group especially individuals who have joined and participates in a group organization."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24704] "1. The act of agreeing. 2. Harmony of opinion; accord. (from American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24705] "Exclusion; the act of restricting entrance or barring from participation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24706] "Payment; a sum of money paid."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24707] "Category; used informally to mean a class of things."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24708] "Classified; arranged in classes or categories."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24709] "Options; alternative choices or actions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24710] "Report; a short account."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24711] "Small; limited in number or quantity or magnitude or extent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24712] "Appearance; the outward or visible aspect of a person or thing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24713] "Partial; being or affecting only a part; not total"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24714] "Course; a connected series of events or actions or developments"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24715] "End Date; the calendar date on which an event ceased."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24716] "Maiden Name; a woman's surname before marriage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24717] "Given."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24718] "Begin Date; the calendar date on which an event began."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24719] "A system for describing the extent of cancer in a patient?s body. T describes the size of the tumor and whether  it has invaded nearby tissue, N describes any lymph nodes that are involved, and M describes metastasis (spread of cancer from one body part to another)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24720] "The condition of being allowed to enter."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24721] "The counting of cells, especially blood cells, using a cytometer or hemocytometer. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24722] "Benefits; the positive effects of something."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24723] "Local-Regional; affecting only a restricted part or area of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24724] "The part of the human body between the neck and the diaphragm or the corresponding part in other vertebrates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24725] "Index; a numerical scale used to compare variables with one another or with some reference number."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24726] "Analysis; examination and interpretation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24727] "Manufacturer Name; the name of a business engaged in manufacturing some product"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24728] "Comments; a written explanation or criticism or illustration that is added to a book or other textual material."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24729] "A dose of medicine in the form of a small pellet."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24730] "Telephone; electronic equipment that converts sound into electrical signals that can be transmitted over distances and then converts received signals back into sounds."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24731] "An act or means of approaching, or, the right to enter or use. (from American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24732] "Application; the work of applying something."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24733] "Clinical; relating to a clinic or conducted in or as if in a clinic and depending on direct observation of patients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24734] "Having to do with the pelvis (the lower part of the abdomen located between the hip bones)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24735] "The Zubrod Score is one scale for indicating a patient's functional level: 0 Asymptomatic; 1 Symptomatic, fully ambulatory; 2 Symptomatic, in bed < 50% of the day; 3 Symptomatic, in bed > 50% of the day but not bedridden; 4 Bedridden; 5 Dead."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24736] "Deviating from the norm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24737] "A control number unique to an object, used to identify it among the other objects in a collection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24738] "The process of obtaining subjects for a study."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24739] "Action; a thing done."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24740] "The date a trial was opened to accrual."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24741] "Added; extra. (from American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24742] "The location at which an organization or person can be reached. (from American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24743] "Next to or adjoining."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24744] "The act of administration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24745] "Written notification to the FDA that a subject in a study has experienced an adverse event."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24746] "Far along in course."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24747] "One associated with."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24748] "Associated with."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24749] "Aliquot; pertaining to a portion of the whole; any one of two or more samples of something, of the same volume or weight."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24750] "Available in place of something else."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24751] "Amended; corrected, or altered formally."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24752] "The total quantity or number."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24753] "Amplification; addition of extra material."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24754] "The transitional zone between the moist, hairless, modified skin of the anal canal and the perianal skin. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24755] "Analyzed; having been subject to examination and interpretation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24756] "Anatomic; relating to anatomy."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24757] "Anterolateral; denoting the area of the body in front and away from the middle line."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24758] "Relating to or located at the tip (an apex). (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24759] "Approach; a way of entering or leaving."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24760] "Approved; established by authority; given authoritative approval."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24761] "Assignment; an undertaking that you have been assigned to do."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24762] "Used to indicate position, location, or state (American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24763] "Atypical; varying from the norm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24764] "Available; obtainable or accessible and ready for use or service."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24765] "Basis; the fundamental assumptions underlying an explanation or a relation that provides the foundation for something."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24766] "Begin; have a beginning, in a temporal, spatial, or evaluative sense."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24767] "Best; having the most positive qualities."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24768] "Relating to, or performed by, both hands."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24769] "Biochemical; of or relating to biochemistry; involving chemical processes in living organisms."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24770] "Biphasic; having two phases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24771] "Blocks; refers to preserved specimens embedded in support material."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24772] "Bone Marrow Stem Cell Transplantation is the transfer of bone marrow stem cells from one organism to another."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24773] "Boost; increase or raise."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24774] "The boundary of a surface or object."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24775] "Bottom; the lowest part, side, or surface of anything"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24776] "Calcified; having calcium deposited on or in an anatomic structure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24777] "The Cancer and Leukemia Group B (CALGB) is a national clinical research group - network of 29 university medical centers, over 185 community hospitals and more than almost 3000 physicians - sponsored by the NCI, with its Central Office headquartered at the University of Chicago, and its Statistical Center located at Duke University, founded in 1955 with a goal of bringing together clinical and laboratory research."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24778] "The amount that can be contained."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24779] "A natural hollow or sinus within the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24780] "Center; a point or area that is approximately central within some larger region or structure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24781] "Change; alteration or modification."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24782] "Characteristics; distinguishing qualities of a person, object, or substance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24783] "Something observed through clinical or radiologic examination."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24784] "Closest; indicating the one of several that is the shortest distance away."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24785] "Coated; covered with an outer layer or film."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24786] "The Children's Oncology Group was formed by the merger of the four national pediatric cancer research organizations: the Children's Cancer Group, the Intergroup Rhabdomyosarcoma Study Group, the National Wilm's Tumor Study Group, and the Pediatric Oncology Group. The primary objective of the organization is to conduct clinical trials of new therapies for childhood cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24787] "Collected; brought together in one place."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24788] "The act of gathering something together."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24789] "Combined; made or joined or united into one or involving the joint activity of two or more."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24790] "Complicating; making more complex or intricate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24791] "Concurrent; occurring or operating at the same time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24792] "Condition; a state of fitness; a state at a particular time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24793] "Confirmed; having been established or verified."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24794] "Congestive; relating to or affected by an abnormal collection of blood or other fluid."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24795] "Consent; permission to do something."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24796] "Contact; a channel for communication between groups."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24797] "Coordinating; bringing into common action, movement, or condition"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24798] "Count; the total number counted"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24799] "The collective generic term \"Country\" refers to a wide variety of dependencies, areas of special sovereignty, uninhabited islands, and other entities in addition to the traditional countries or independent states. (from CIA World Factbook 2002: http://www.cia.gov/cia/publications/factbook/docs/notesanddefs.html)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24800] "Person employed by a study sponsor or Contract Research Organization to monitor a clinical study at all participating sites. (from centerwatch.com glossary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24801] "Criteria; a basis for comparison; a reference point against which other things can be evaluated."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24802] "Critical; being in or verging on a state of crisis or emergency; urgently needed; absolutely necessary."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24803] "Common Toxicity Criteria; a set of terminology used to report adverse events in clinical trials."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24804] "Cumulative; increasing by successive addition."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24805] "Current; occurring in or belonging to the present time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24806] "Cycle; a periodically repeated sequence of events."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24807] "Daily; occurring or done each day."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24808] "A collection of facts from which conclusions may be drawn."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24809] "Declining; becoming progressively lower, growing weaker, or going from better to worse."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24810] "Delay; time during which some action is awaited; inactivity resulting in something being put off until a later time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24811] "Delayed; caused to be slower or later."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24812] "Dermal; of or relating to or located in the dermis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24813] "Designated; selected or named for a duty."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24814] "Particulars considered individually and in relation to a whole."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24815] "Detected; perceived or discerned."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24816] "Diagnostic; characteristic or indicative of e.g. a disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24817] "Dimension; the magnitude of something in a particular direction, especially length or width or height."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24818] "Discontinued; stopped permanently or temporarily."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24819] "Display; exhibiting openly in public view; a visual representation of something."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24820] "Disruption; an event that results in a displacement or discontinuity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24821] "Dominant; exercising influence or control."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24822] "The amount of medicine taken, or radiation given, at one time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24823] "Dryness; lacking moisture, or the feeling thereof."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24824] "During; at some time in."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24825] "The Eastern Cooperative Oncology Group (ECOG) was established in 1955. This is a cooperative group (Philadelphia, PA) funded primarily by the NCI, one of the largest clinical cancer research organizations in the US, incorporating universities, medical centers, Community Clinical Oncology Programs, and Cooperative Group Outreach Programs with almost 6000 physicians, nurses, pharmacists, statisticians, and clinical research associates from the US, Canada, and South Africa. ECOG has more than 90 active clinical trials in all types of adult malignancies. Annual accrual is 6,000 patients, with more than 20,000 patients in follow-up."                                                                                                                                                                                                                                                                                                                                        
[24826] "Effect; a phenomenon that follows and is caused by some previous phenomenon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24827] "Elevated; raised or increased."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24828] "Elevation; the condition of being elevated."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24829] "Emotional; excessively affected by emotion."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24830] "End; the point in time at which an event ceases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24831] "Entire; constituting the full quantity or extent; complete."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24832] "Estimated; calculated approximately."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24833] "Event; something that happens at a given place and time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24834] "Examined; having been subjected to an examination."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24835] "Expected; considered likely or probable."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24836] "Situated outside of a capsule, esp. outside the capsular ligament of a joint."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24837] "Outside of, or unrelated to, any medulla, especially the medulla oblongata."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24838] "Situated outside of a node."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24839] "Situated outside of the prostate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24840] "Factor; anything that contributes causally to a result."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24841] "Field; a branch of knowledge."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24842] "Final; conclusive in a process or progression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24843] "First; preceding all others in time or space or degree."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24844] "Relating to or resembling a fissure."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24845] "Foci; plural of focus; a central point or locus of an infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24846] "Foreign; not belonging to that in which it is contained; introduced from an outside source."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24847] "Formation; the act of forming something."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24848] "Fraction; a small part or item forming a piece of a whole."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24849] "Frequency; the number of occurrences within a given time period."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24850] "From; used to indicate a specified place or time as a starting point."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24851] "Full; containing as much or as many as is possible or normal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24852] "Function; what something is used for."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24853] "Further; to or at a greater distance in time or space."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24854] "Gingival; of or relating to the gums."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24855] "The Gynecologic Oncology Group (GOG) is a non-profit NCI-supported organization headquartered in Philadelphia, PA, with the purpose of promoting excellence in the quality and integrity of clinical and basic scientific research in the field of gynecologic malignancies. Approximately 45 individual clinical trials are active at any one time within GOG."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24856] "Granulopenic; relating to or resembling granulocytopenia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24857] "Grouping; a system for classifying things into groups; the activity of putting things together in groups."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24858] "Test for identification of breast cancer patients with tumors that produce excessive amounts of the HER-2 protein."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24859] "Highest; approaching or constituting a maximum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24860] "Histologic; of or relating to histology."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24861] "Histologically; involving the use of histology or histological techniques."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24862] "Hormonal; relating to hormones."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24863] "In modern usage, an hour is defined as a unit of time 60 minutes, or 3600 seconds in length. It is approximately 1/24 of a median day."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24864] "The International Breast Cancer Study Group (IBCSG), created as the 'Ludwig Breast Cancer Study Group' in 1977, is dedicated to innovative clinical research designed to improve the prognosis of women with breast cancer. Patients and investigators from six continents: Europe, Australia/ New Zealand, Africa, Asia, and North and South America, cooperate by participating in extensive clinical trials in the Adjuvant breast cancer setting. IBCSG has been a pioneer in research into combined hormonal therapy and chemotherapy, timing and duration of Adjuvant Therapies, and Quality of Life of breast cancer patients. (from ibcsg.org)"                                                                                                                                                                                                                                                                                                                                             
[24865] "Immature; in an early period of life or development or growth."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24866] "Inclusion; the state of being included."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24867] "Increase; a process of becoming larger or more numerous or more important."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24868] "The quality of being hard, the process of hardening, or an abnormally hard spot or place, particularly of the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24869] "Inflammatory; relating to inflammation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24870] "Initial; occurring at the beginning."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24871] "Initials; the first letter of a word, especially a person's name."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24872] "Intake; the substances, or the quantities thereof, taken in and utilized by the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24873] "Intensity is a measure of the time averaged energy flux. To calculate the intensity, take the energy density (the energy per unit volume) and multiply it by the velocity at which the energy is moving. The resulting vector has the units of power divided by area (i.e. Watt/square meter).  Anything that can carry energy can have an intensity associated with it, but intensity is used most frequently with waves (i.e. sound or light). (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24874] "Interlobar; between lobes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24875] "International; concerning or belonging to two or more nations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24876] "Interruption; a time interval during which there is a temporary cessation of something."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24877] "A period of time between two events or occurrences. (from the American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24878] "Into; expressing entrance, or a passing from the outside of a thing to its interior parts."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24879] "Intraclavicular; within the clavicles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24880] "Invaded; penetrated or assaulted, in a harmful or injurious way."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24881] "Involved; connected by participation or association or use."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24882] "Involvement; a connection by participation or association or use."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24883] "Isolated; marked by separation of or from usually contiguous elements."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24884] "Largest; greatest in size of those under consideration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24885] "Last; coming after all others in time or space or degree or being the only one remaining."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24886] "Lead; be in charge of."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24887] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24888] "Level; a position on a scale of intensity or amount or quality."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24889] "The bottom of the normal range for a particular laboratory result."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24890] "Lobar; of or relating to or affecting a lobe."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24891] "Lobular; of or relating to or resembling a lobule."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24892] "Longest; having the greater length of two or the greatest length of several."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24893] "Loss; a gradual decline in amount or activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24894] "Lost; parted with; no longer held or possessed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24895] "Lymphovascular; of or relating to the lymphatic vessels."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24896] "Main; most important; principal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24897] "Margin; the boundary line or the area immediately inside the boundary."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24898] "Maximum; the largest possible quantity or degree."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24899] "Mesorectal; of or relating to the fold of peritoneum, or mesentery, attached to the rectum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24900] "Metaplastic; pertaining to or characterized by metaplasia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24901] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24902] "Microinvasive; exhibiting or pertaining to microinvasion, the microscopic extension of malignant cells into adjacent tissue in carcinoma in situ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24903] "Middle; an area that is approximately central within some larger region."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24904] "Minimum; the smallest possible quantity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24905] "Mode; a particular functioning condition or arrangement."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24906] "Modification; the act of making something different."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24907] "Modified; changed in form or character."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24908] "Molecular; relating to or produced by or consisting of molecules."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24909] "Mononuclear; possessing a single nucleus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24910] "Monophasic; occurring in or characterised by only one phase or stage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24911] "Most Recent; nearest to the present."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24912] "Myocardial; of or pertaining to the myocardium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24913] "Myometrial; of or pertaining to the myometrium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24914] "One criteria of the TMN staging system.  N refers to the extent of lymph node involvement."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24915] "The North Central Cancer Treatment Group (NCCTG) is a national clinical research group sponsored by the NCI. The research base for NCCTG is located at Mayo Clinic in Rochester, Minn. NCCTG consists of a network of more than 1,000 cancer specialists at community clinics, hospitals and medical centers in 25 states in US, two Canadian provinces and Mexico. NCCTG specializes in researching methods of treating and preventing cancer, and in researching methods to alleviate the side effects of cancer and cancer treatments."                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24916] "The National Cancer Institute of Canada acts in concert with its partner the Canadian Cancer Society, and with The Terry Fox Foundation, to provide support for cancer research and related programs undertaken at Canadian universities, hospitals and other research institutions. (www.ncic.cancer.ca)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24917] "Nearest; most near in time or space."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24918] "Nervous; of or relating to the nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24919] "The cell of a pigmented cutaneous nevus that differs from a normal melanocyte in that it lacks dendrites. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24920] "New; having no previous example or precedent or parallel."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24921] "Newly Diagnosed; very recently determined."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24922] "Not cancerous."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24923] "Non-Measurable; not possible to be measured."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24924] "Non-Protocol; treatment not specified in a protocol."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24925] "Non-Surgical; not pertaining to or amenable to surgery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24926] "Non-Target; other than the one for which something is done."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24927] "Non-Visceral; not relating to or affecting the viscera."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24928] "Not; used for negation of a word or group of words."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24929] "The numerical result of analysis of a breast cancer based on the Nottingham Prognostic Index."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24930] "The nursing of an infant at the mother's breast."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24931] "Nutritional; of or relating to or providing nutrition."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24932] "Observation; watching something and taking note of what happens."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24933] "Observed; discovered or determined by scientific observation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24934] "Occupational; of or relating to the activity or business for which a person is trained."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24935] "Off-Treatment; the phase of a protocol during which a patient does not receive treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24936] "Opposite; being directly across from each other."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24937] "Optional; possible but not necessary; left to personal choice."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24938] "Original; preceding all others in time or being as first made or performed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24939] "Overall; including everything."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24940] "A term used to describe cancer that can be felt by touch, usually present in lymph nodes, skin, or other organs of the body such as the liver or colon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24941] "Regions near to the parametrium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24942] "Participating; taking part in an activity."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24943] "Past; before the present time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24944] "Pathologic; caused by or altered by or manifesting disease or pathology."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24945] "Pectoral; of or pertaining to the chest."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24946] "Penetration; the act of entering into or through something."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24947] "Percentage; a fraction or ratio with 100 understood as the denominator."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24948] "Surrounding the colon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24949] "(pear-ih-NOOR-al) Around a nerve or group of nerves."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24950] "Period; an amount of time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24951] "Surrounding the prostate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24952] "Of or pertaining to the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24953] "Planned; devised, contrived, or formed in design."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24954] "Platinum-Based; derived from or containing platinum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24955] "Any system designed to expedite the sorting and delivery of mail by assigning a series of alphanumeric codes to each delivery area.  Also used to refer to any individual delivery area code."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24956] "Denoting the back surface of the body; at or near the hind end in quadrupeds or toward the spine in primates."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24957] "Post-Operative; relating to or occurring during the period immediately following a surgical operation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[24958] "(pre-KAN-ser-us) A term used to describe a condition that may (or is likely to) become cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24959] "The act or process of preparing."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24960] "Present; the period of time that is happening now."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24961] "Occurring prior to something else."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24962] "First or foremost in importance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24963] "Earlier in time or order."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24964] "the act of moving forward toward a goal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24965] "Projected; calculated, estimated, or predicted based on present data or trends."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24966] "An area which is governed as part of a country or an empire. (from Cambridge International Dictionary of English)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24967] "Proximity; the property of being close together."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24968] "Reason or intention."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24969] "Qualifying; success in satisfying a test or requirement."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24970] "Rate; a magnitude or frequency relative to a time unit."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24971] "Reaction; a bodily process occurring due to the effect of some foregoing stimulus or agent."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[24972] "An explanation of the cause of some phenomenon or action."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24973] "Received; taken, gotten, or acquired."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24974] "Reduced; made less in size or amount or degree."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24975] "Reference; a short note acknowledging a source of information or quoting a passage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24976] "Referring; sending or directing for treatment, information, or a decision."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24977] "In oncology, describes the body area right around a tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24978] "Registered; listed or recorded officially."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24979] "Registering; the act of listing or recording officially."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24980] "Registration; the act of enrolling."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[24981] "Regular; conforming to a standard or pattern."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[24982] "Related; connected or associated."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[24983] "Remaining; enduring or persisting."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24984] "Removed; taken out of or separated from."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24985] "Reporting; the act of providing a short account."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[24986] "Required; necessary, not optional."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[24987] "(ree-SEK-tuh-bull) Part or all of an organ that can be removed with surgery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[24988] "Resected; having been removed by surgery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[24989] "Resolution; something settled or resolved; the outcome of decision making."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[24990] "Respiratory; pertaining to respiration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24991] "Responsible Person; a person worthy of responsibility or trust or one held accountable."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24992] "Restart; take up or begin anew."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24993] "Retrieval; the operation of accessing information from storage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[24994] "Retrotracheal; denoting the area behind the trachea."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[24995] "Reviewing; reexamining or reconsidering."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[24996] "Sampling; the selection or making of a sample."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[24997] "Satellite; situated near; accompanying."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[24998] "Scale; an ordered reference standard."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[24999] "Scheme; an elaborate and systematic plan of action."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25000] "Second; coming next after the first in position in space or time or degree or magnitude."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25001] "Secondary; of second rank or importance or value; not direct or immediate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25002] "A very thin slice (of tissue or mineral or other substance) for examination under a microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25003] "Security; freedom from anxiety or fear."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25004] "Self-Administered; self given or applied."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25005] "Seminal; pertaining to or containing or consisting of semen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25006] "Sent; caused or enabled to go or be conveyed or transmitted."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25007] "Sequence; serial arrangement in which things follow in logical order or a recurrent pattern."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25008] "A number of things or events standing or succeeding in order, and connected by a like relation. (from On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25009] "Serum Immunologic; refers to immunologic features of or immunologic tests done on serum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25010] "Severity; used of the degree of something undesirable e.g. pain or weather."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25011] "Shape; the spatial arrangement of something as distinct from its substance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25012] "Signature; your name written in your own handwriting."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25013] "Signed; having a handwritten signature."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25014] "Sister; a female sibling."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25015] "Size; the physical magnitude of something."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25016] "Slice; a thin flat piece cut off of some object."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25017] "Source; where something is available."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25018] "Special; surpassing what is common or usual or expected."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25019] "Specify; be specific about something; define clearly."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25020] "Social Security Number; a nine digit taxpayer identification number resembling \"123-45-6789\" which is issued to an individual by the Social Security Administration of the United States federal government."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25021] "State; the way something is with respect to its main attributes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25022] "Status; a condition or state at a particular time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25023] "The process of classifying patients into strata as part of the randomization process or for purposes of data analysis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25024] "Street Address; the street component of an address."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25025] "Subcarinal; below the carina."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25026] "Subcategory; a subdivision that has common differentiating characteristics within a larger category."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25027] "Subgroup; a distinct and often subordinate group within a group."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25028] "Submission; a message submitted for the judgment of others."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25029] "Submitted; referred for judgment or consideration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25030] "Subtype; a group forming a type within a larger type."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25031] "Sum; the final aggregate amount."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25032] "Surgical; of or relating to or involving or used in surgery or requiring or amenable to treatment by surgery."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25033] "The Southwest Oncology Group (SWOG) is an NCI-sponsored cooperative group, an adult cancer clinical trials organization, one of the largest in the world. The group was established in 1956 and is headquartered in San Antonio, TX. Its network consists of almost 4,000 of the physicians at 283 institutions throughout the US and Canada. The major goal of the SWOG since 1990 has been to enroll more women and minority patients in cancer treatment and control research trials."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25034] "System; a group of independent but interrelated elements comprising a unified whole."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25035] "Taken; having accepted for some purpose."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25036] "Target; the goal intended to be attained."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25037] "Term; a limited period of time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25038] "Text; the words of something written."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25039] "Treating; providing treatment for."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25040] "The top of the normal range for a particular laboratory result."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25041] "Uncoated; not having a coating."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25042] "Unfiltered; lacking a filter."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25043] "Unit of Measure; a predetermined quantity (as of length, time, or heat) adopted as a standard of measurement."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25044] "Update; bring up to date; supply with recent information or technology."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25045] "Having to do with urine or the organs of the body that produce and get rid of urine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25046] "Value; a numerical quantity measured or assigned or computed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25047] "Variation; something that deviates from a norm or standard; an instance of change."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25048] "Version; something a little different from others of the same type; one of a sequence of copies of a program, each incorporating new modifications."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25049] "Vertebral; of or relating to or constituting vertebrae."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25050] "Visit; the act of going to see some person or place or thing; it can cover a short or long period but refers to a non-permanent arrangement."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25051] "Vital Status; whether a person is alive or dead (or unknown)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25052] "Without; used as a function word to indicate the absence or lack of something or someone. (from Merriam-Webster OnLine)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25053] "Worst; to the highest degree of inferiority or badness; the least favorable outcome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25054] "A system designed to expedite the sorting and delivery of mail by assigning a series of numbers to each delivery area in the United States.  Also used to refer to any individual delivery area code. (from the American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25055] "Refers to cells that develop into connective tissue, blood vessels, and lymphatic tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25056] "serving to aid or contribute; auxiliary. (Merriam-Webster OnLine)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25057] "Dermoid; resembling skin; skinlike."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25058] "Refers to the area where nerves and blood vessels attach to an organ."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25059] "Intent; an anticipated outcome that is intended or that guides your planned actions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25060] "Having to do with the pancreas."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25061] "One criteria of the TMN staging system.  M refers to the presence of metastasis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25062] "One criteria of the TMN staging system.  T refers to the extent of tumor involvement at the primary site (T, followed by a number indicating size and depth of invasion)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25063] "Following the stated course of action or treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25064] "Concomitant; following as a consequence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25065] "Cribriform; having the appearance of a sieve: containing many perforations."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25066] "Ductal; related to, or having the quality of, a duct."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25067] "In a lump; as a whole; used to refer to autopsy techniques in which visceral organs are removed in large blocks allowing the prosector to retain a continuity in organ architecture during the subsequent dissection. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25068] "Breslow's thickness. maximal thickness of a primary cutaneous melanoma measured in tissue sections from the top of the epidermal granular layer, or from the ulcer base (if the tumor is ulcerated), to the bottom of the tumor; metastatic rates correlate closely with tumor thickness. (from On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25069] "breathing in."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25070] "Fibrinogen; a fibrillar protein present in blood plasma; it converts to fibrin when blood clots."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25071] "Identified; having the identity known or established."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25072] "Infarction; localized necrosis resulting from obstruction of the blood supply."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25073] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25074] "Erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25075] "Physician; a licensed medical practitioner."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25076] "the state of being pregnant; the period from conception to birth when a woman carries a developing fetus in her uterus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25077] "the discharge of urine."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25078] "loss of ability to function normally."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25079] "gradual healing (through rest) after sickness or injury."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25080] "Measurement of the clearance of endogenous creatinine, used for evaluating the glomerular filtration rate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25081] "The capacity of iron-binding protein in serum (transferrin) to bind serum iron. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25082] "Pulse; the rhythmic contraction and expansion of the arteries with each beat of the heart."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25083] "a symptom of reduced quality or strength."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25084] "Bronchoscopist; a doctor or technician who operates a bronchoscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25085] "The diffusion or accumulation in a tissue or cells of substances not normal to it or in amounts above normal."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25086] "In medicine, an improvement related to treatment."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25087] "Movement from one place to another."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25088] "The formation of a break on the skin or on the surface of an organ.  An uncer forms when the surface cells die and are cast off.  Ulcers may be associated with cancer and other diseases."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25089] "A peptide vaccine consisting of amino acids 12 through 20 of the viral oncoprotein human papillomavirus (HPV) 16 E7. Vaccination with HPV-16 E7 peptide may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for HPV-16 E7, resulting in decreased tumor growth. HPV-16 infection is tumorigenic and highly associated with cervical cancer. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25090] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25091] "Agents able to covalently bind to DNA causing inter- or intra-stranded cross-linking of DNA.  The cross-linking results in misreading of the DNA code and inhibition of DNA synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25092] "Any anatomical feature created by surgery.  This includes structures created to mimic the function of a structure removed by surgery or destroyed by disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25093] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25094] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25095] "An acute myeloid leukemia secondary to a myelodysplastic syndrome or therapy-related.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25096] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25097] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25098] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25099] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25100] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25101] "Ankyrin Repeat-Containing Protein KRIT1, encoded by the CCM1 gene, interacts with ICAP-1 and may be involved in bidirectional signaling between integrin molecules and the cytoskeleton. KRIT1 may help determine endothelial cell shape and function in response to cell-cell and cell-matrix interactions by guiding cytoskeletal structure. Defects in the CCM1 gene are responsible for the development of cerebral cavernous malformations, a relatively rare disease causing vascular malformations that may involve any part of the central nervous system. KRIT1 may affect cell adhesion processes via integrin signaling in CCM1 pathogenesis. KRIT1 also interacts with RAP1A (a member of the Ras family of GTPases) and may be involved in the RAP1A signal transduction pathway in vasculogenesis or angiogenesis. KRIT1 contains 4 ankyrin repeats, 1 band 4.1-like domain, and 1 FERM domain. (From NCI)"                                                                           
[25102] "Cyclin B2, encoded by the CCNB2 gene, is a member of the cyclin family of CDK kinase regulatory subunits, specifically the B-type cyclins. Cyclin B2 is primarily associated with the Golgi region. Cyclin B2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. Cyclin B2 interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex, activating and imparting substrate specificity to the complex. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/CDC2 may play a key role in transforming growth factor beta-mediated cell cycle control. Cyclin B2 accumulates steadily during G2 and is abruptly destroyed at mitosis. Overexpression of cyclins B, resulting from different mechanisms, could contribute, through an alteration of the spindle checkpoint, to the chromosomal instability observed in cancer. (From LocusLink, PMID and NCI)"                                                 
[25103] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25104] "Chemokine Receptor Genes (GPCR Family) encode cell surface Chemokine Receptors, seven-transmembrane G protein-coupled receptor glycoproteins that bind to chemokines and mediate the migration of pro-inflammatory cells. Like chemokines, the chemokine receptors can be divided, according to variations in a shared cysteine motif, into at least three structural branches: CR, CCR, and CXCR. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25105] "Chemokine (C-C Motif) Receptor 1, encoded by the CCR1 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene may have roles in host protection from inflammatory response, and susceptibility to virus and parasite. (From LocusLink and NCI)"                                                                                                                                                                                                                                       
[25106] "Chemokine (C-C Motif) Receptor 5, encoded by the CCR5 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. This receptor is expressed by T cells and macrophages, and is an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene is associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene is also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. (From LocusLink and NCI)"                                                                                  
[25107] "Chemokine (C-C Motif) Receptor 6, encoded by the CCR6 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. The CCR6 gene is preferentially expressed by immature dendritic cells and memory T cells. This receptor mediates intracellular calcium flux and binds specifically to the CC chemokine macrophage inflammatory protein 3 alpha (MIP-3 alpha). It is important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                      
[25108] "Chemokine (C-C Motif) Receptor 8, encoded by the CCR8 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. This receptor is expressed preferentially in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) are ligands of this receptor. This receptor and its ligands regulate monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                             
[25109] "Expressed in placenta, lung, lymphatic endothelia, lymph nodes, intestinal mucosa/submucosa, hemopoietic cells, and fetal liver by human CCBP2 Gene (GPCR1/Beta Chemokine Receptor Family), Chemokine (C-C Motif) Receptor 9 is a seven transmembrane G protein-coupled receptor for many beta chemokines (MCP1, MIP1-alpha, RANTES, MCP3) and is critical for recruitment of effector immune cells to inflammation sites. CCBP2 does not mediate intracellular calcium flux but may function in chemokine-driven recirculation of leukocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25110] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25111] "The KRAS2 gene encodes p21 K-RAS protein, two KRAS isoforms of which are produced by alternative splicing. RAS proteins are involved in transmembrane signal transduction as monomeric GTP-binding proteins, with intrinsic GTPase activity, that alternate between an inactive GDP-bound form and an active GTP-bound form. RAS proteins are activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein. Mitogen-stimulated RAS enhances MYC accumulation by stabilizing MYC protein. This stabilization is dependent on the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC.  Mutations of specific amino acids activate c-RAS to transform cells and are implicated in a variety of human tumors. KRAS is involved in malignancy much more often than is HRAS. (from OMIM, SWISS-PROT and NCI)"                                                                                                                 
[25112] "Human NRAS Gene (RAS Family) encodes p21 N-Ras Protein, involved in transmembrane signal transduction as a monomeric GTP-binding protein with GTPase activity that alternates between inactive/GDP-bound and active/GTP-bound forms. RAS is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein. In response to a RAS/RAF/MAPK pathway, mitogen-stimulated RAS stabilizes MYC protein, enhancing MYC accumulation, by inhibiting proteasome-dependent MYC degradation. Implicated in a variety of human tumors, specific amino acid mutations activate c-RAS and transform cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                               
[25113] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25114] "Chemokine (C-C Motif) Receptor-Like 1, a 45-kD glycosylated protein encoded by the CCRL1 gene, is a G protein-coupled receptor that binds chemokines of the CC subfamily, especially MCP-4, ELC (SCYA19) and TECK (SCYA25). CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. Predominant expression of 5.0, 2.0 and 1.3kb mRNA forms exist in human heart tissue, while low-level expression of the 2.0 and 1.3kb forms in lung, pancreas and spleen and in fetal tissues. The CCRL1 gene has one intron in the 5' untranslated region. (From LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                               
[25115] "Chemokine (C-C Motif) Receptor-Like 2, encoded by the CCRL2 gene, is a seven transmembrane chemokine receptor like protein that is most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. (From LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                               
[25116] "Immunoprotein Genes encode proteins whose activities affect or play a role in immune system functions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25117] "Immunoglobulin Family Genes encode structurally-related Immunoglobulin Family Proteins containing one, or more, 100-aa Immunoglobulin domain that includes a conserved intradomain disulfide bond and may be involved in protein-protein or protein-ligand interactions. Immunoglobulin Family members include hundreds of functionally diverse proteins, such as Immunoglobulins, the muscle kinase titin, and receptor tyrosine kinases. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25118] "The CD3 complex mediates signal transduction. The TCR/CD3 complex of T lymphocytes consists of either a TCR Alpha/Beta or TCR Gamma/Delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled Gamma, Delta, Epsilon, Zeta, and Eta. CD3E Antigen, Epsilon Polypeptide (Tit3 Complex) is encoded by the CD3E gene. Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25119] "The Ig constant chain domains and a single extracellular domain in each type of MHC chains are homologous andapproximately 100 amino acids long, and include a conserved intradomain disulfide bond. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. This subfamily is the C-2-type and includes glycoproteins and other unrelated proteins with immunoglobin domains eg.carcinoembryonic antigens and fibroblast growth factor receptors. (InterPro IPR003598)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25120] "The immunoglobulin (Ig) constant chain domains and a single extracellular domain in each type of MHC chains are homologous and approximately 100 amino acids long, and include a conserved intra-domain disulfide bond. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. The V-type immunoglobins contain the V regions of the Ig molecule. (From InterPro IPR003596)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25121] "CD47 Antigen, encoded by the CD47 gene, is a 50-kD membrane protein with an amino-terminal immunoglobulin domain and a carboxyl-terminal multiple-membrane-spanning region. CD47 Antigen is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is also involved in membrane permeability changes induced following virus infection. Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior. The interaction of CD47 with SHPS-1 may contribute to the recruitment of B lymphocytes via endothelial cells under steady state conditions. CD47 Antigen is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. Four isoforms are produced by alternative splicing. (From LocusLink, OMIM, Swiss-Prot and NCI)"                                                                         
[25122] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25123] "A drug that belongs to the family of drugs called sulfonamides.  It is being studied for its ability to treat cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25124] "CD97 Antigen, encoded by the CD97 gene, is a founding member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules. CD97 Antigen is a glycoprotein present on the surface of most activated leukocytes and is a G protein-coupled receptor. This protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing generates two variants. CD97 Antigen has large N-terminal domain with five epidermal growth factor-like sequences which are differentially spliced. (From LocusLink and NCI)"                    
[25125] "Encoded by human ADAM11 Gene (ADAM Family, Peptidase M12b Family), the 769-amino acid 83 kD (precursor) type I membrane ADAM11 Protein (isoforms MDC-769 and MDC-524) is implicated in cell-cell/-matrix interactions of muscle development, neurogenesis, and fertilization. Membrane-anchored ADAM zinc metalloproteases contain disintegrin domains related to snake venom disintegrins. A putative integrin ligand, ADAM11 is a metalloprotease-like noncatalytic protein predominantly expressed in brain that contains an EGF-like domain and a conserved disintegrin domain AVN(E/D)CD motif. The precursor may be cleaved by a furin endopeptidase. ADAM11 disruptions occur in breast and ovarian cancers. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                    
[25126] "Encoded by human CST6 Gene, 149-amino acid 16.5 kD (precursor) Cystatin 6 is a type 2 cystatin. Cystatin superfamily proteins contain multiple cystatin-like sequences. Three inhibitory subfamilies display structural and functional similarities: type 1 stefins, type 2 cystatins, and kininogens. Some members are cysteine protease inhibitors, while others have lost or never acquired inhibitory activity. Type 2 cystatins are endogenous intracellular or extracellular cysteine proteinase inhibitors that appear to provide protective functions. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                    
[25127] "Cell Division Cycle 2-Like 1, encoded by the CDC2L1 gene, is a member of the p34Cdc2 serine/threonine protein kinase family. CDC2L1 is expressed ubiquitously and acts as a negative regulator of the normal cell cycle progression. It may function in regulating proliferation by phosphorylation and subsequent plasma membrane targeting of galactosyltransferase. This gene is deleted or altered frequently in neuroblastoma with amplified MYCN genes. CDC2L1 can be cleaved by caspases and play roles in cell apoptosis. A large number of the alternatively spliced variants of this gene exist. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                    
[25128] "Genes that encode cytoplasmic proteins of both prokaryotes and eukaryotes that bind to nascent or unfolded polypeptides and ensure correct folding or transport. Chaperone proteins do not covalently bind to their targets and do not form part of the finished product. Heat-shock proteins are an important sub set of chaperones. Three major families are recognised, the chaperonins (groEL and hsp60), the hsp70 family and the hsp90 family. Outside these major families are other proteins with similar functions including nucleoplasmin, secB and T-cell receptor associated protein. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                     
[25129] "CDC37 Homolog, encoded by the CDC37 gene, is a protein highly similar to Cdc 37, which is a cell division cycle control protein of Sacchromyces cerevisiae. CDC37 Homolog is a molecular chaperone with specific function in cell signal transduction. It forms complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It plays a critical role in directing the chaperone HSP90 and targeting it to the CDK4 protein kinase, thereby promoting stability of CDK4 in regulating cell division cycle. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                   
[25130] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25131] "Genes (superfamily) that encode GTP hydrolyzing enzymes, which cycle between the GDP-bound inactive state and the GTP-bound active state acting as intracellular switches in various cellular pathways, such as signal transduction. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25132] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25133] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25134] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25135] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25136] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25137] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25138] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25139] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25140] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25141] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25142] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25143] "Cell Division Cycle 42, encoded by the CDC42 gene, is a small GTPase of the Rho-subfamily. This protein regulates signaling pathways that control diverse cellular functions, including cell morphology, migration, endocytosis and cell cycle progression, and the induction of malignant trasnformation. ACK1 is a binding partner and inhibitor of the GTP-bound form of CDC42. Interaction between GTP-CDC42 and ACK1 inhibits both the intrinsic and GAP-stimulated GTPase activity of CDC42. The product of oncogene Dbl specifically catalyzes the dissociation of GDP from CDC42. This protein regulates actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of the CDC42 gene results in the placental and brain isoforms. (From LocusLink, OMIM and NCI)"                                                                                                              
[25144] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25145] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25146] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25147] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25148] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25149] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25150] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25151] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25152] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25153] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25154] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25155] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25156] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25157] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25158] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25159] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25160] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25161] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25162] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25163] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25164] "A liposome-encapsulated form of the antineoplastic antibiotic annamycin.  Less toxic than annamycin, liposomal annamycin also shows improved antitumor properties compared to its parent compound. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25165] "Cyclin-Dependent Kinase Genes encode Cyclin-Dependent Kinases, eukaryotic phosphoregulated protein kinases that physically associate with cyclins to achieve full enzymatic activity and control cell cycle progression. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25166] "These genes encode member proteins of the highly conserved cyclin family. They are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. (From RefSeq Summary and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25167] "Cyclin-Dependent Kinase 10, encoded by the CDK10 gene, is a protein that belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members bind to cyclin to form active holoenzymes that play a pivotal role in the regulation of the eukaryotic cell cycle and are known to be essential for cell cycle progression. This kinase has been shown to play roles in cellular proliferation and its function is limited to cell cycle G2-M phase. A variety of different transcripts exist, resulting from cryptic splice sites, exon skipping, insertion of intronic sequences, and exon scrambling. The splicing of this gene is complex. At least three alternatively spliced variants of this gene exist, one of which contains multiple non-ATG translation initiation sites. (From LocusLink, OMIM and NCI)"                                                                                                                                                         
[25168] "Cyclin-Dependent Kinase 2, encoded by the CDK2 gene, belongs to the CDKX subfamily of the Ser/Thr protein kinase family. This protein kinase is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. It is involved in promoting DNA synthesis and cell cycle progression. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene exist. Its N-terminal domain interacts with cyclins and C-terminal domain interacts with CSK1. (From LocusLink, OMIM and NCI)"                                                                                                                                       
[25169] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25170] "cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. (LocusLink)"                                                                                                                                                                                     
[25171] "Encoded by human DSS1 Gene (DSS1/SEM1 Family), 70-amino acid 8 kD DSS1 Protein is a highly conserved acidic protein predominantly expressed in limb bud, craniofacial primordia, and skin. A human homolog of the highly conserved cytosolic SEM1 (S. cerevisiae), DSS1 may be involved in completion of the cell cycle or in a differentiation process. Containing three oligonucleotide-binding folds and a helix-turn-helix motif, DSS1 Protein directly interacts with a 90 kD C-terminal domain of BRCA2 that binds single-stranded DNA. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                     
[25172] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25173] "Encoded by human DDR1 Gene (PTK Family, Insulin Receptor Subfamily), 913-amino acid 101 kD (precursor) Epithelial Discoidin Domain Receptor 1, a type I membrane protein homolog of mouse Ptk3, is largely expressed in epithelial cells of kidney, lung, gastrointestinal tract, and brain. DDR1 exhibits extracellular Discoidin I motifs; GLY/PRO-rich domains likely required for ligand or substrate interaction; a F5/8 type C domain; and a novel N-terminal region with homology to a factor VIII domain. The C-terminal catalytic domain has type II receptor tyrosine kinase motifs. Neurotrophin TRKs - TRKA, TRKB, and TRKC - regulate development and survival of specific neuronal lineages. Activated by type I-VI collagens, NTRK4 may be a non-neuronal receptor for a NGF or involved in cell-cell interactions or cell adhesion. (from Swiss-Prot Q08345 and NCI)"                                                                                                               
[25174] "Encoded by human DUSP3 Gene, 185-amino acid 20.5 kD conserved VH1-Related Phosphatase is a non-receptor member of the dual specificity protein phosphatase subfamily (Protein-Tyrosine Phosphatase Family) that inactivates target substrates by dephosphorylating phosphotyrosine and phosphoserine/threonine residues. Negative regulators of MAPK/ERK, SAPK/JNK, and p38 members associated with cellular proliferation and differentiation, dual specificity phosphatases show different tissue distributions and subcellular locations, distinct substrate specificities for MAP kinases, and different modes of induction by extracellular stimuli. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                         
[25175] "CDK Inhibitor Proteins, encoded by the CDK Inhibitor genes, are a group of low molecular weight proteins that associate with cyclin-CDK complexes or CDKs alone and inhibit their activity. (From OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25176] "CDK2-Associated Protein 1, encoded by the CDK2AP1 gene, is a specific CDK2-associated protein that negatively regulates CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein also interacts with DNA polymerase alpha/primase and promotes the phosphorylation of the large p180 subunit, which suggests the regulatory role in DNA replication during S phase of the cell cycle. Reduction of CDK2AP1 protein expression is a frequent event in oral cancers and is a negative prognostic indicator in patients with surgically resected oral squamous cell carcinoma. Loss of CDK2AP1 protein expression may contribute to the multistep nature of oral carcinogenesis. (From LocusLink, PubMed and NCI)"                                                                                                                                                                                                                                               
[25177] "Encoded by human FGFR4 Gene (FGFR Family), 802-amino acid 87.9 kD (precursor) type I membrane protein Fibroblast Growth Factor Receptor 4 is a receptor tyrosine kinase with three extracellular Ig-like C2-type domains, a cytoplasmic tyrosine kinase domain, and 55% amino acid identity with FLG (FGFR1) and BEK. FGFR family amino acid sequence is highly conserved; the extracellular domain interacts with FGFs, signaling downstream cascades that influence mitogenesis and differentiation. FGFRs differ in ligand affinities and tissue distribution. Predominantly expressed in lung, FGFR4 expression is distinct from FLG, BEK, and FGFR3. Unlike FGFR1-3, FGFR4 IgIII domain C-terminal half does not vary. Although function is unknown, FGFR4 preferentially binds acidic FGF and FGF19; it does not bind to basic FGF. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                         
[25178] "Encoded by human GAS11 Gene, 56 kD Growth Arrest Specific 11 Protein is a ubiquitous 478-amino acid putative tumor suppressor protein. GAS11 amino acid sequence is 96% identical to the mouse homolog, expressed during growth arrest. (from Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25179] "Encoded by human SLC22A1L Gene (Polyspecific Transporter/Multidrug Resistance Family), 424-amino acid Organic Cation Transporter-Like 2 Protein has ten transmembrane segments. Highest expression occurs in liver, heart, and kidney. The SLC22A1L organic cation transporter protein is localized on the apical surface of renal proximal tubules and appears to confer resistance/transport activity to chloroquine and quinidine-related compounds. Renal epithelial cell apical and basolateral polyspecific organic-cation transporters mediate excretion of endogenous and exogenous compounds. (from OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                         
[25180] "ADAMs are transmembrane proteins containing both a disintegrin and a metalloprotease domain. Two thirds of the proteins with an ADAM type metalloprotease domain also contain the zinc protease pattern which locates the active site of these proteases. As they contain an adhesion domain and a protease domain, ADAM proteins potentially have both cell adhesion and protease activities. They play a role in various biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-alpha release and inflammatory response. In ADAMTS proteins, a closely related family of proteases, the metalloprotease and disintegrin domains are flanked by thrombospondin type I (TSP1) repeat. ADAMTS proteins are soluble, extracellular matrix proteases. (From InterPro IPR001590)"                                                                                                                                                                                       
[25181] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25182] "Cyclin-Dependent Kinase 3, encoded by the CDK3 gene, belongs to the SER/THR family of protein kinases. CDK3 can phosphorylate histone H1. CDK3 is involved in the control of the cell cycle. CDK3 participates in the G1-S transition at least primarily by binding to E2F-1, E2F-2, or E2F-3 through DP-1 and by enhancing their transcriptional activities. CDK3 also interacts with cyclin E and cyclin A and Ik3-1/Cables is a novel substrate for CDK3-mediated phosphorylation by CDK3/cyclin E and CDK3/cyclin A. (From LocusLink, PubMed and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25183] "Complementary DNA(cDNA) clone inserts are robotically printed onto a glass slide and subsequently hybridized to two differentially fluorescently labeled probes. The probes are pools of cDNAs, which are generated after isolating mRNA from cells or tissues in two states that one wishes to compare. (From NHGRI, Microarray Project)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25184] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25185] "Processes that mark, promote, and sustain the commencement of, and commitment to continue, cellular processes involved in the S phase of the cell cycle, such as replication. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25186] "Transmembrane Protein Genes encode integral membrane proteins with a transmembrane region."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25187] "Transferase Genes encode enzymes (Transferases) that transfer a group, such as a methyl group or a glycosyl group, from one compound (donor) to another (acceptor). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25188] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25189] "Kinase Family Genes encode Kinase enzymes that covalently transfer the terminal, gamma phosphate group from ATP to a variety of substrates and typically play key regulatory roles in diverse cellular functions."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25190] "Serine/Threonine Protein Kinase Genes encode enzymes (Serine/Threonine Protein Kinases) that catalyze phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25191] "Cyclin-Dependent Kinase-Like 2, encoded by the CDKL2 gene, is a member of a large family of CDC2-related serine/threonine protein kinases. CDKL2 is expressed as 2 major transcripts in adult testis and kidney, and at lower levels in adult brain and lung. A single transcript is detected in fetal brain and, at very low levels, in fetal kidney. This protein accumulates primarily in the cytoplasm, with a lower level in the nucleus. Treatment of cultured cells with epidermal growth factor causes an increase in the CDKL2 activity, but this does not require phosphorylation of the conserved MAP kinase dual phosphorylation motif present in this kinase. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                                                          
[25192] "Cyclin-Dependent Kinase Inhibitor 2C, encoded by the CDKN2C gene, is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with monomeric CDK4 or CDK6, and prevent the activation of the CDK kinases, thus control cell cycle G1 progression. It inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein Rb. Two alternatively spliced transcript variants of this gene encode an identical protein. This protein contains 4 ANK repeats and is found in pancreas and heart, with the highest levels in skeletal muscle. Inactivation of CDKN2C by point mutations may contribute to deregulated growth control in certain cell lines and/or tumors. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                   
[25193] "Cyclin-Dependent Kinase Inhibitor 3, encoded by the CDKN3 gene, is a dual-specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. This protein is a cyclin-dependent kinase inhibitor and may play a role in cell cycle regulation. It has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. Delay of cell cycle progression is dependent on CDKN3 phosphatase activity. This protein also interacts with other cyclin-dependent kinases such as CDC2 and CDK3, but not with CDK4. The CDKN3 gene is deleted, mutated, or overexpressed in several kinds of cancers. Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC). (From LocusLink, Swiss-Prot, OMIM and NCI)"                                                                                                                                                                                          
[25194] "Dual-specificity protein phosphatases are a subclass of protein tyrosine phosphatases that are uniquely able to hydrolyse the phosphate ester bond on both a tyrosine and a threonine or serine residue on the same protein. Dual-specificity phosphatases have a central role in the complex regulation of signalling pathways that are involved in cell stress responses, proliferation and death. (from Nat Rev Drug Discov 2002;1:961-76)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25195] "Surface Glycoprotein, Ig Superfamily Member, encoded by the human CDON gene, is a cell surface glycoprotein and a member of the immunoglobulin superfamily. Rhabdomyosarcoma is a childhood tumor of the skeletal muscle lineage in which cells display defects in both biochemical and morphological aspects of differentiation. The immunoglobulin superfamily members CDO and BOC are components of a cell surface receptor that positively regulates myogenesis in vitro. CDO and BOC may play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage. (From PubMed 12720294, LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                
[25196] "Cerebellar-Degeneration-Related Antigen 1, encoded by the human CDR1 gene, is one of the target molecules recognized by autoantibodies directed against neuronal proteins in patients with paraneoplastic cerebellar degeneration, which occurs in association with small cell carcinoma of the lung, neoplasms of the breast and ovary, and Hodgkin disease. This protein contains tandem hexapeptide repeats and is expressed in brain, predominantly in normal neuroectodermal tissues and in certain malignant tumors. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25197] "All homeodomain proteins contain the homeodomain, a region of structural similarity present in certain prokaryotic and eukaryotic DNA-binding proteins.  Eukaryotic homeodomain proteins are encoded by homeobox genes and typically control gene expression during morphogenesis and development."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25198] "Caudal Type Homeo Box Transcription Factor 2, encoded by the human CDX2 gene, is a homeodomain protein. This nuclear protein is involved in the transciptional regulation of multiple genes expressed in the intestinal epithelium. It is important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Phosphorylation of Ser-60 of this protein mediates the transactivation capacity. CDX3 binds an A/T-rich sequence in the insulin promoter and stimulate its transcription. Increased CDX2 mRNA is associated with chronic atrophic gastritis and expression of CDX2 may trigger the initiation and development of intestinal metaplasia. In contrast, markedly reduced or absent CDX2 expression is noted in most large cell minimally differentiated carcinomas. (From LocusLink, Swiss-Prot, OMIM and NCI)"                                                                                   
[25199] "Members of the CEA Family Gene encode the members of the CEA Family Protein, which consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. (From OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25200] "Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. (From OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25201] "N Domain is one of the seven predicted immunoglobulin-like domains that members of the CEA family protein have. It is extremely hydrophobic. (From OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25202] "Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7, encoded by the human CEACAM7 gene, belongs to the carcinoembryonic antigen (CEA) family in the immunoglobulin superfamily. It contains one immunoglobulin-like V-type domain and one immunoglobulin-like C2-type domain. This protein is a potential tumor suppressor protein and strongly down-regulated in colon adenocarcinomas. Two isoforms (2a and 2b) of this protein are produced by alternative splicing. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25203] "Cadherin EGF LAG Seven-Pass G-Type Receptor 1, encoded by the human CELSR1 gene, is a G-Protein Coupled Receptor that may have an important role in cell/cell signaling during nervous system formation. It is an integral membrane protein with seven transmembrane domains, multiple cadherin repeats, EGF-like repeats, and laminin A G-type repeats. Two isoforms (1 and 2) may be produced by alternative splicing. The CELSR1 gene is developmentally regulated and neural-specific and the protein plays an unspecified role in early embryogenesis. (From LocusLink, Swiss-Prot, PubMed and NCI)"                                                                                                                                                                                                                                                                                                                                                                                           
[25204] "Serotonin 5-HT-3 Receptor, encoded by the human HTR3 gene, is one of the several different receptors for serotonin (5-hydroxytryptamine, 5-HT), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Whereas all other known serotonin receptor subtypes are G protein-coupled receptors, this receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Two isoforms, 1/5-HT3R-AS and 2/5-HT3R-AL, are produced by alternative splicing. (From OMIM, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                            
[25205] "The HTR3 gene at 11q23.1-q23.2 encodes Serotonin 5-HT-3 Receptor, one of the several different receptors for serotonin (5-hydroxytryptamine, 5-HT), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Whereas all other known serotonin receptor subtypes are G protein-coupled receptors, this receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Two isoforms, 1/5-HT3R-AS and 2/5-HT3R-AL, are produced by alternative splicing. (From OMIM, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                        
[25206] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25207] "CHK1 Checkpoint Homolog, encoded by the human CHEK1 gene, is a serine/threonine protein kinase that is required for the DNA damage checkpoint. This protein is involved in cell cycle arrest when DNA damage has occurred or when unligated DNA is present. It binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25C on serine-216 creates a binding site for 14-3-3 protein which inhibits CDC25C. This prevents activation of the CDC2-Cyclin B complex and prevents mitotic entry. This protein is expressed ubiquitously with the most abundant expression in thymus, testis, small intestine, and colon. (From LocusLink, Swiss-Prot, PubMed and NCI)"                                                                                                                                                                                                                                                                                                              
[25208] "Choline Kinase, encoded by the human CHK gene, produces phosphocholine from choline. The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. Choline kinase is the initial enzyme in the sequence and may play a regulatory role. Choline kinase also catalyzes the phosphorylation of ethanolamine. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25209] "Cholinergic Receptor, Muscarinic 4, encoded by the human CHRM4 gene, is a G protein-coupled receptor. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and postassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                         
[25210] "Generally speaking, this term describes an experimental format in which probes representing genes that one wants to study are affixed to a substrate (e.g., a glass slide) and then exposed to target molecules (sometimes referred to as the sample). The level of hybridization between a specific probe and a target (typically indicated through fluorescence and measured through image analysis) indicates the level of the gene corresponding to that probe in a test solution. (From CHI Outlook Microarrays report)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25211] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25212] "Investigator; a scientist who devotes himself to doing research; a researcher in a clinical trial or clinical study."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25213] "The double membrane structure surrounding the mitochondrion and separating it from the cell cytoplasm.  The two membranes are separated by an intermembrane space. The electron transport chain resides in the inner mitochondrial membrane."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25214] "The nuclear envelope has two membranes, each with a typical unit membrane in structure. They enclose a flattened sac and are connected at the nuclear pore sites. The inner nuclear membrane separates the perinuclear cistern of the endoplasmic reticulum from the nucleoplasm. It is attached to and supported by the lamina. A growing number of proteins that are specifically located to this membrane seem to participate in functionally organizing the nucleus. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25215] "Oxidoreductase Genes encode the class of enzymes that catalyze oxidation/reduction reactions (Oxidoreductases). The oxidized substrate is regarded as a hydrogen donor. Systematic enzyme names employ dehydrogenase wherever possible, or reductase; oxidase is only used where O2 is the acceptor.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25216] "The nuclear envelope has two membranes, each with the typical unit membrane structure. They enclose a flattened sac and are connected at the nuclear pore sites. The outer nuclear membrane is continuous with the rough endoplasmic reticulum (ER) and has ribosomes attached. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25217] "Isomerase Genes encode enzymes (Isomerases) that catalyze spatial or structural changes within a molecule by rearrangement or transfer of specific atoms or moieties to a new intramolecular location to form a new single product. The reactions do not involve a net change in the concentrations of compounds other than the substrate and the product. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25218] "Polymerase Genes encode enzymes (Polymerases) that catalyze polymerization reactions, especially of nucleotides to polynucleotides. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25219] "Ligase Genes encode Ligases, a large major class of enzymes that catalyze the formation of a linking covalent bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25220] "This protein is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                           
[25221] "A salt that is comprised of a hydrogen and chloride ion that can be linked to a base form of a drug making it water-soluble. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25222] "An organic salt or ester of maleic acid that could be conjugated to free base compounds/drugs to improve the physiochemical properties including stability, solubility and dissolution rate. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25223] "Esterase Genes encode Esterases that catalyze hydrolysis of ester bonds to produce alcohol and acid reaction products. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25224] "Ribonuclease Genes encode (Ribo)nucleases that specifically catalyze the cleavage of phosphate ester linkages in ribonucleic acids; endoribonucleases cleave internal bonds and exoribonucleases cleave bonds at termini. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25225] "Endoribonuclease Genes encode hydrolytic Endoribonucleases that hydrolyse internal ribonucleotide bonds of polynucleotides to yield oligonucleotides. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25226] "Human RNase III Gene at 5p13.3 encodes 2 alternative isoforms of ubiquitous 1374-aa 159-kDa nuclear Ribonuclease III, containing a DRBM domain and 2 RNase III domains. Involved in pre-rRNA processing, RNase III endonucleolytically cleaves double-strand, not single-strand, RNA to 5'-phosphomonoester. RNase III interacts with Sp1 and a fraction is translocated to the nucleolus during S phase. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25227] "The human DICER1 gene at 14q32.2 encodes Endoribonuclease Dicer. This protein possesses an RNA helicase motif, containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. It is required by the RNA interference in cleaving double-stranded RNA as well as small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. The 21 to 23 bp double-stranded RNAs (siRNAs) generated target the selective destruction of homologous RNAs. (From OMIM, Swiss-Port, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25228] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25229] "The Double-Stranded RNA Binding Domain is found in a variety of RNA-binding proteins with different structures and exhibiting a diversity of functions. It is involved in localization of at least five different mRNAs in the early Drosophila embryo and by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA. (InterPro IPR001159)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25230] "A hydrolase enzyme which makes oligonucleotides and polynucleotides by hydrolysing the interior bonds of ribonucleotides. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25231] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25232] "Endoribonuclease Dicer, encoded by the human DICER1 gene, possesses an RNA helicase motif, containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. It is required by the RNA interference in cleaving double-stranded RNA as well as small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. The 21 to 23 bp double-stranded RNAs (siRNAs) generated target the selective destruction of homologous RNAs. (From OMIM, Swiss-Port, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25233] "Encoded by human oncogene ANP32B Gene, 272-amino acid 31 kD PHAPI2 is similar to PHAPI.  (Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25234] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25235] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25236] "Expressed in a variety of tissues, Toll-Like Receptor Family Genes encode type I transmembrane Toll-Like Receptor proteins, containing a TIR domain and multiple LRR repeats, which respond to various microbial components and mediate pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLRs typically act via MyD88 (TIR interaction) and TRAF6, activating NF-Kappa-B, cytokine production and secretion, and inflammatory response. (NCI)"                                                                                                                                                                                                                                                                                                   
[25237] "MicroRNA (miRNA) is a form of single-stranded RNA of typically 20-25 nucleotides long, and regulates the expression of other genes. miRNAs are transcribed from RNA genes, but are not translated into protein. A miRNA is complementary to a part of one or more messenger RNAs (mRNAs). The annealing of the miRNA to the mRNA results in a double-stranded RNA, which is not transcribed into protein. In many cases, this double-stranded RNA triggers the degradation of the mRNA transcript through a process similar to RNA interference. The miRNA prevents the protein biosynthesis of a specific gene, namely the one to whose mRNA it is complementary. (From http://www.wikipedia.org/wiki/MicroRNA and NCI)"                                                                                                                                                                                                                                                                           
[25238] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25239] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25240] "Cytoplasmic Protein Genes encode Cytoplasmic Proteins that are typically localized in the cell interior, generally excluding the plasma membrane, mitochondria, and the nucleus. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25241] "Chediak-Higashi Syndrome 1, encoded by the human CHS1 gene, is Lysosomal-Trafficking Regulator Protein. This 425-kD cytoplasmic protein may sort endosomal resident proteins into late multivesicular endosome by a mechanism involving microtubules. It contains 7 WD repeats (TRP-ASP domains) and 1 beach domain, and is abundantly expressed in adult and fetal thymus, peripheral blood leukocytes, bone marrow and several regions of the adult brain. At least 3 isoforms (1, 2, 3) are produced by alternative splicing. Defects in the CHS1 gene are the cause of Chediak-Higashi Syndrome (CHS), an inherited immunodeficiency disease characterized by giant lysosomes and impaired leukocyte degranulation. (From LocusLink, Swiss-Prot, PubMed and NCI)"                                                                                                                                                                                                                               
[25242] "Originally identified in the Rous sarcoma virus src transforming gene, Non-Receptor Tyrosine Kinase Genes encode Protein Tyrosine Kinases, enzymes important in control of cell growth, proliferation, differentiation, and transformation that do not function as receptors, but catalyze tyrosine phosphorylation of proteins with ATP, or other nucleotides as phosphate donors.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25243] "Non-Receptor Protein Tyrosine Phosphatase Genes encode Non-Receptor Protein Tyrosine Phosphatases, one of the two main categories (soluble and transmembrane receptor) of enzymes that catalyze removal of a tyrosine-attached phosphate group and are important in control of cell growth, proliferation, differentiation, and transformation. Two cysteines in the catalytic domain (one absolutely required for activity) are generally conserved; other conserved residues in the vicinity are important. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25244] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25245] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25246] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25247] "Suppressor of Cytokine Signaling (SOCS/SSI) Family Genes encode cytokine-specific-inducible negative feedback regulators that function downstream of cytokine receptors to attenuate signal transduction. Suppressor of Cytokine Signaling Proteins contain SH2 and SOCS BOX domains and are implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. SOCS proteins interact with multiple tyrosine kinase activated signaling proteins and inhibit cytokine signal transduction by binding to tyrosine kinase receptors. SOCS proteins regulate cell growth and survival, placental development, hematopoiesis, and T-cell allergic responses. (NCI)"                                                                                                                                                                                                                                                                                                                     
[25248] "Encoded by Suppressor of Cytokine Signaling (SOCS/SSI) Family Genes, Suppressor of Cytokine Signaling Family Proteins are cytokine-specific-inducible negative feedback regulators that function downstream of cytokine receptors to attenuate signal transduction. Containing SH2 and SOCS BOX domains, SOCS proteins are implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. SOCS proteins interact with multiple tyrosine kinase activated signaling proteins and inhibit cytokine signal transduction by binding to tyrosine kinase receptors. SOCS proteins regulate cell growth and survival, placental development, hematopoiesis, and T-cell allergic responses. (NCI)"                                                                                                                                                                                                                                                                                       
[25249] "Cytokine Inducible SH2-Containing Protein, encoded by the human CISH gene, is a cytokine-inducible negative regulator of cytokine signaling. This protein contains a SH2 domain and a SOCS box domain. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein is involved in the inactivation of the erythropoietin receptor. Association with EPOR may target this protein for proteolysis by the ubiquitin-dependent proteasome pathway. The CISH protein is mainly monoubiquitinated (37 kD) but may also exist in a polyubiquitinated form (45 kD). Three isoforms (1, 1B, 1C) are produced by alternative splicing, and the tissue distribution of isoforms 1 and 1B is distinct. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                
[25250] "The SOCS box is an approximately 40 amino acid region of homology invariably located at the C-terminus of the proteins in which it is present. Initially identified in the SOCS, or supressors of cytokine signaling family of proteins, the SOCS box appears to be involved in targeting proteins for ubiquitination. The SOCS box contains a sub-domain known as the BC-box that is also found in the VHLa domain. The BC box in both SOCS box and VHLa domain facilitates binding to the Elongin BC complex. Elongin BC, in turn, interacts with the von-Hippel Lindau (VHL) tumor suppressor protein to form the core of the larger VCB E3 ubiquitin protein ligase complex. Thus, the SOCS box/VHLalpha domain may serve a function analogous to the structurally related F-box protein linking substrates to E3 complexes to allow ubiquitination. Five classes of N-terminal regions are found associated with the C-terminal SOCS box. (Pawson Lab, SLRI, Mount Sinai Hospital, 2003)"      
[25251] "Membrane-Associated Guanylate Kinase Family Genes encode MAGUK (Membrane-Associated GUanylate Kinase homolog) proteins containing DHR, SH3, and C-terminal GK-like domains. MAGUKs include Drosophila lethal(1)discs large-1 tumor suppressor protein (dlg1); mammalian Zo-1 tight junction protein; mammalian synaptic proteins that seem to interact with the cytoplasmic tail of NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1 and SAP102); 55 kD erythrocyte membrane protein (p55); C. elegans lin-2 protein; rat CASK protein; and human DLG2 and DLG3 proteins. An N-terminal ATP-binding site (P-loop) of Guanylate Kinase is not conserved in the MAGUK GK-like domain; MAGUKs do retain residues known in GK to bind GMP. (NCI)"                                                                                                                                                                                                                                   
[25252] "Interleukin Genes encode Interleukins, soluble cytokine factors produced by leukocytes and other cell types that have broad functional activities, particularly in regulating the inflammatory and immune responses of a variety of cell types. Interleukins enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules, and responses to immune and inflammatory stimuli. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25253] "Processes that promote, sustain, and preserve nerve cell viability. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25254] "Cardiotrophin-Like Cytokine, encoded by the human CLC gene, is a cytokine of the IL-6 family. This protein stimulates nerve cell survival and B-cell proliferation. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25255] "Chemokine-Like Receptor 1, encoded by the human CMKLR1 gene, is an orphan receptor that belongs to G Protein-Coupled Receptor. This protein may be a chemotactic peptide receptor. It is expressed during bone development and may have a function in bone metabolism. It is prominently expressed in developing osseous and cartilaginous tissue. It is also found in adult parathyroid glands. It also acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Two isoforms (A, B) are produced by alternative splicing. (From Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                        
[25256] "Members of the polo subfamily of protein kinases appear to play pivotal roles in cell division and proliferation. These include mammalian Plk, Snk, and Fnk/Prk, Xenopus laevis Plx1, Drosophila melanogaster polo, Schizosaccharomyces pombe Plo1, and Saccharomyces cerevisiae Cdc5. The polo family members are characterized by the presence of a distinct region of homology in the C-terminal non-catalytic domain, termed the polo-box, which is essential for subcellular localization and mitotic functions of the polo kinases. Regulation of polo kinases may be crucial in the control of cell division. (http://tdcb.nci.nih.gov/cradaopp13.html)"                                                                                                                                                                                                                                                                                                                                     
[25257] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25258] "Cytokine-Inducible Kinase, encoded by the human CNK gene, is a serine/threonine protein kinase that is involved in regulating M phase functions during the cell cycle. This membrane-associated protein may play a role in regulation of cell cycle progression and tumorigenesis. It may also be part of the signaling network controlling cellular adhesion. It is phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis. Cytokine and cellular adhesion trigger CNK induction. CNK contains both a catalytic domain and a putative regulatory domain. It binds to the calcium/integrin-binding protein (CIB) and this interaction probably occurs via the polo-box domain. Transcripts expression appears to be down-regulated in primary lung tumor. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                           
[25259] "Homeostasis is the body's maintenance of a consistent internal environment within a narrow range of variation. It is important to the continuation of life. (from http://www.usc.edu/dept/biomed/bme403/Section_1/homeostasis.html)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25260] "Connector Enhancer of KSR-Like (Drosophila Kinase Suppressor of Ras) is encoded by the human CNK1 gene. Drosophila CNK is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. Drosophila CNK interacts with RAF and localizes to cell junctions, required by several pathways stimulated by receptor tyrosine kinases. The function, location or structure of human CNK1 remains unknown. (From OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                 
[25261] "Signal Transducer and Activator of Transcription Family Genes encode dual function cytoplasmic Signal Transducer and Activator of Transcription (STAT) proteins that are activated by tyrosine phosphorylation in response to a large number of cytokines, growth factors, and hormones. After activation they form homodimers or heterodimers that translocate to the nucleus where they either bind directly to regulatory DNA cis-elements of specific target genes or act together with other DNA-binding proteins in multiprotein transcription complexes to direct transcription. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                      
[25262] "Ion Channel Protein Genes encode Ion Channel Proteins that typically aggregate in membrane-associated complexes forming pores whose activities regulate the movement of ions through cellular membranes to affect cellular homeostatic conditions and/or signaling processes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25263] "Peptide Hormone Genes encode Peptide Hormones, typically synthesized as larger precursor molecules from which are derived smaller active proteins that function as hormonal signals secreted by one tissue or organ and have physiological effects on other tissues or organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25264] "A class of agents that inhibit the enzyme ribonucleic acid (RNA) polymerase, which catalyzes the polymerization of an RNA strand from a DNA template. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25265] "Genes with Unknown or Unclassified Function encode Proteins (or RNAs) with Unknown or Unclassified Function. The cellular functions of these products are currently unidentified or unspecified. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25266] "A class of genes that encode signaling pathway proteins that function to mediate the coupling of multiple cell surface receptors to downstream signaling pathways in the regulation of various cellular functions. (from Oncogene 2001;20:6315-21)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25267] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25268] "Contactin Associated Protein 1, encoded by the human CNTNAP1 gene, was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. This transmembrane protein includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. This protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. This gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The protein is predominantly expressed in brain and weak expression is detected in ovary, pancreas, colon, lung, heart, intestine and testis. (From LocusLink, Swiss-Prot, and NCI)"                                                                                                                                                                     
[25269] "Extracellular Matrix Protein Genes encode mostly fibrous Extracellular Matrix Proteins (e.g., Collagen, Elastin, Fibronectins, and Laminin), typically located in the Extracellular Matrix and commonly involved in cell attachment, cell movement, cell growth, morphogeneseis, organogenesis, and tissue repair, architecture, and organization. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25270] "Collagen Genes encode different forms of Collagen, the principle fibrous protein of connective tissue, all consisting of triple helix alpha-polypeptide chains. Collagen is differentiated from other fibrous proteins by its content of proline, hydroxyproline, and hydroxylysine; by its absence of tryptophan; and by its high content of polar groups. Hydroxyproline residues likely promote the triple helical fibrous structure of collagen. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25271] "Collagen IV (Alpha 3),encoded by the human COL4A3 gene, is a subunit of type IV collagen, the major structural component of basement membranes. In Goodpasture syndrome, autoantibodies bind to collagen in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized to the non-collagenous C-terminal domain of this protein. There are 6 alternate transcripts unique to this gene and alternate splicing is restricted to the 6 exons encoding this domain. This protein is widely expressed. Two protein isoforms (1 and 2/Delta26/GPBPD26) are produced by alternative splicing. This gene is also linked to the autosomal recessive Alport syndrome. The mutations contributing to this syndrome are also located within the exons encoding this C-terminal region. This protein phosphorylates the Goodpasture autoantigen in vitro on Ser and Thr residues. Isoform 2 seems less active. (From LocusLink, Swiss-Prot and NCI)"          
[25272] "Protease Genes encode Proteases, a subclass of peptide hydrolases primarily classified by catalytic mechanism: Exopeptidases; Serine Endopeptidases; Cysteine Endopeptidases; Aspartic Endopeptidases; Metalloendopeptidases; and a group of enzymes yet to be assigned to a subclass. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25273] "A set of genes coding for diverse proteins which, by virtue of their high degree of sequence similarity, are believed to have evolved from a single ancestral gene. (from On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25274] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25275] "Trafficking Protein Genes encode proteins involved in various cellular sorting and transport mechanisms - such as gated transport, protein translocation, and vesicular transport - whereby cellular proteins are positioned, sorted, and directed to, sequestered in, or moved from one cellular compartment to another specific correct subcellular cellular compartment for proper function. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25276] "Collagen IV (Alpha 6), encoded by the human COL4A6 gene, is a subunit of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                           
[25277] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25278] "CC Cytokine Genes encode Beta Chemokines, CC-type dual-cysteine chemokines with adjacent cysteine residues in their primary sequence that act as chemoattractants for lymphocytes, monocytes, eosinophils, and basophils, but not for neutrophils. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25279] "CXC Cytokine Genes encode Alpha Chemokines, CXC-type dual-cysteine chemokines with paired cysteine residues separated by a non-cysteine residue in their primary sequence that act as chemoattractants for neutrophils, but not for monocytes. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25280] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25281] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25282] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25283] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25284] "Organic substances belonging to diverse chemical families and present in foods in minute amounts, Vitamins are essential to normal metabolism and biochemical functions, usually as coenzymes. Vitamins can be classified by solubility: lipo-soluble (vitamins A, D, E, K, F) and water-soluble (B- complex). Lack of one or more vitamins in the diet cause metabolic deficiency diseases. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25285] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25286] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25287] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25288] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25289] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25290] "An iatrogenic condition is a state of ill health caused by medical treatment, usually due to mistakes made in treatment. The word literally means \"caused by a doctor\". (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25291] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25292] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25293] "Cytochrome C Oxidase Subunit Vic is encoded by the human COX6C gene. Cytochrome C Oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The nuclear-encoded subunits may be involved in the regulation and assembly of the complex. The COX VIc subunit is found in all mammalian tissues. This mitochondrial protein does not have a presequence that targets mitochondria and the mature form itself has the property of a presequence. A pseudogene COX6CP1 has been found on chromosomes 16p12. (From LocusLink and NCI)"                                                                                                                                                                                                                    
[25294] "RAEB: Any aspect of vaccine research, development, testing, etc., for diseases other than AIDS. A vaccine must involve the administration of an antigen to induce an active and specific immune response. Induction of passive immunity does not constitute a vaccine although the term is sometimes misused for this process."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25295] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25296] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25297] "Casein Kinase 1, Alpha 1, encoded by the human CSNK1A1 gene, is a serine/threonine protein kinase and has broad specificity. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. This cytoplasmic protein can phosphorylate a large number of proteins. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25298] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25299] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25300] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25301] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25302] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25303] "A gene that encodes a protein that is associated with any of the cell membranes.  These may be intrinsic, transmembrane proteins or peripheral proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25304] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25305] "Copine VII, encoded by the human CPNE7 gene, is a calcium-dependent membrane-binding protein. Molecular events at the interface of the cell membrane and cytoplasm may be regulated by proteins that attach to and detach from the membrane surface in response to signals. Calcium-dependent membrane-binding proteins may play such a role. Copine VII contains two N-terminal C2 domains and one von Willebrand factor A domain. It may function in membrane trafficking. Two isoforms (1 and 2) may be produced by alternative splicing. This gene has been excluded as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3. (NCI)"                                                                                                                                                                                                                                                                                                                                   
[25306] "Some isozymes of protein kinase C (PKC) contain a domain, known as C2, of about 116 amino-acid residues which is located between the two copies of the C1 domain (that bind phorbol esters and diacylglycerol) and the protein kinase catalytic domain. Regions with significant homology to the C2-domain have been found in many proteins. The C2 domain is thought to be involved in calcium-dependent phospholipid binding. Since domains related to the C2 domain are also found in proteins that do not bind calcium, other putative functions for the C2 domain such as binding to inositol-1,3,4,5-tetraphosphate have been suggested. The 3D structure of the C2 domain of synaptotagmin has been reported, the domain forms an eight-stranded sandwich constructed around a conserved 4-stranded motif, designated a C2 key. Calcium binds in a cup-shaped depression formed by the N- and C-terminal loops of the C2-key motif. (From Pfam 00168)"                                       
[25307] "The type A domain (vWF) of the von Willebrand factor, a large multimeric glycoprotein found in blood plasma, is the prototype for a protein superfamily. Von Willebrand Factor A Domain is found in various plasma proteins and other extracellular proteins. Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome. A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWF domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction), involving interaction with a large array of ligands. A number of human diseases arise from mutations in VWA domains. (From Interpro IPR002035)"                                                                           
[25308] "Processes and mechanisms that block angiogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25309] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25310] "Hematopoietic Factor Genes encode growth factors that promote the development of blood cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25311] "Colony-Stimulating Factor Genes encode Colony-Stimulating Factors, autocrine or paracrine glycoprotein growth factors that act synergistically on several bone marrow progenitor cells to regulate myeloid differentiation and stimulate production of blood cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25312] "RGS Family Genes encode evolutionarily conserved proteins containing the RGS (Regulator of G protein Signaling) domain and generally function as negative regulators of heterotrimeric G protein signaling; several promote the GTPase activity of G protein alpha-subunits, causing it to revert to its inactive (GDP-bound) form. (OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25313] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25314] "Sushi domains, also known as Complement control protein (CCP) modules or short consensus repeats (SCR), exist in a wide variety of complement and adhesion proteins. The structure is known for this domain, it is based on a-sandwich arrangement; one face made up of three-strands hydrogen-bonded to form a triple-stranded region at its center and the other face formed from two separate strands. (From Pfam PF00084)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25315] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25316] "Autoimmune Status; the state of a person's health in regard to autoimmune disease or antibody presence."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25317] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25318] "Interstitial space between cells, occupied by fluid as well as amorphous and fibrous substances. (On-Line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25319] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25320] "Helicase Genes encode proteins that promote unwinding of 1.) RNA during splicing and translation or 2.) duplex DNA during replication or repair by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25321] "Protein Tyrosine Phosphatase Genes encode Protein Tyrosine Phosphatases, enzymes that specifically remove tyrosine-bound phosphate groups from many phosphoproteins, including many enzymes phosphorylated by a tyrosine kinase. Together with protein tyrosine kinases, Tyrosine Phosphatases regulate tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25322] "A type of globulin in plasma that in electrically charged solutions exhibits greatest colloidal mobility among that of serum globulins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25323] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25324] "Usually a protein, it is produced in the granular endoplasmic reticulum and the Golgi complex.  Morphologically, it is defined as a membrane-bound particle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25325] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25326] "Protein Serine/Threonine Phosphatase Genes encode Protein Serine/Threonine Phosphatases, a group of enzymes that specifically dephosphorylate phosphoserine and phosphothreonine residues in specific target proteins. Together with serine/threonine protein kinases, these enzymes regulate serine and threonine phosphorylation and dephosphorylation of target proteins in cellular signal transduction pathways typically involved in cell growth control. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25327] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25328] "Ubiquitin Ligase Genes encode eukaryotic enzymes (Ubiquitin Ligases) involved in de/ubiquitination of cellular proteins with ubiquitin through its C-terminus. Regulating the half-lives of many proteins by targeting them for degradation, ubiquitination is associated with many regulated events including protein degradation, chromatin remodeling, heat shock, cell cycle progression, differentiation, antigen presentation, retrovirus assembly, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                          
[25329] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25330] "Bone Morphogenetic Protein Genes (TGF Beta Superfamily) encode 9 structurally related Bone Morphogenetic Proteins, non-collagenous bone-growth regulatory factors synthesized as large precursor molecules that are cleaved by proteolytic enzymes and form an active homodimer or heterodimer of two related bone morphogenetic proteins that stimulate osteogenesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25331] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25332] "Phosphotransferase Genes encode Phosphotransferases (Phosphatases), a large group of enzymes subdivided according to acceptor group that transfer phosphate, diphosphate, nucleotidyl residues, and other phosphomoieties. Some phosphotransferases catalyze the conversion of a proenzyme to an active enzyme; others transfer phosphate groups to form triphosphates (e.g., ATP). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25333] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25334] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25335] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25336] "Cullin Family Genes encode Cullin Family Proteins, which are components of SCF ubiquitin ligase complexes or E3 ubiquitin ligase complexes with elongin BC complexes and other factors, involved in ubiquitination and proteasomal degradation of target cell cycle, signal transduction, and transcription proteins. Cullins may act in these multisubunit complexes as a scaffold for substrates and ubiquitin-conjugating enzymes and interact with RBX1, RNF7, CYCE, and/or TIP120A/CAND1. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25337] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25338] "Encoded by human Arrestin Beta 1 Gene, 418-amino acid 47 kD Beta-Arrestin 1 (Arrestin Family) regulates Beta-Adrenergic Receptor function.  Beta-Arrestins appear to bind phosphorylated Beta-Adrenergic receptors, impairing G(s) protein activation.  (Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25339] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25340] "Colony Stimulating Factor 3, encoded by the CSF3 gene, is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Three transcript variants encoding three different protein isoforms have been found for this gene. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25341] "Colony Stimulating Factor 3, encoded by the CSF3 gene, is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Three transcript variants encoding three different protein isoforms have been found for this gene. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25342] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25343] "ATPase, Aminophospholipid Transporter-Like, Class I, Type 8A, Member 2, encoded by the ATP8A2 gene, is an integral membrane protein has similarity to P-type ATPases, proteins that drive uphill transport of ions across membranes. Transfection of antisense constructs into a nontumorigenic cell line rendered the cells tumorigenic in nude mice. (from Swiss-Prot and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25344] "Casein Kinase 2, Alpha 1 Polypeptide is encoded by the CSNK2A1 gene. Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. This kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. Three transcript variants encoding two different isoforms have been found for this gene. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25345] "Chondroitin Sulfate Proteoglycan 4 (CSPG4), encoded by the CSPG4 gene, plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25346] "Chondroitin Sulfate Proteoglycan 6 (CSPG6), encoded by the CSPG6 gene, is an abundant secreted chondroitin sulfate proteoglycan in basement membranes and an intracellular protein. CSPG6 is nvolved in chromosome cohesion during cell cycle and in DNA repair as a central component of the cohesin complex, which is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis and in chromosome movement. (from LocusLink)"                                                                                                                                                                                                                                            
[25347] "C-Terminal Binding Protein 2, one of the two distinct proteins encoded by the CTBP2 gene, is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25348] "Cardiotrophin 1 was cloned via its ability to potently induce cardiac myocyte hypertrophy in vitro.  It is a member of the family of cytokines that includes leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and interleukin 6 (IL6). Several members of this family that are known to signal through the transmembrane protein gp130 stimulate cardiac myocyte hypertrophy, like cardiotrophin 1, suggesting that the gp130 signaling pathway may play a role in cardiac hypertrophy. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25349] "Cathepsin Z, encoded by the CTSZ Gene, is a lysosomal cysteine proteinase. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. Cathepsin Z has also been known as cathepsin X and cathepsin P. The CTSZ gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25350] "Cullin 1, encoded by the CUL1 gene, is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, Cullin 1 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. It may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. (from Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25351] "This protein is a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin II, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. (from LocusLink)"                                                                     
[25352] "Encoded by human CUL2 Gene (Cullin Family), 745-aa 87-kDa Cullin 2 is a component of multisubunit E3 ubiquitin ligase complexes with elongin BC complexes and other factors. Involved in the third step of ubiquitin conjugation, CUL2 may act as scaffold that positions substrate and the ubiquitin-conjugating enzyme. CUL2 interacts with RBX1, RNF7, and TIP120A/CAND1. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25353] "Encoded by Cullin Family Genes, Cullin Family Proteins are components of SCF ubiquitin ligase complexes or E3 ubiquitin ligase complexes with elongin BC complexes and other factors, involved in ubiquitination and proteasomal degradation of target cell cycle, signal transduction, and transcription proteins. Cullins may act in these multisubunit complexes as a scaffold for substrates and ubiquitin-conjugating enzymes and interact with RBX1, RNF7, CYCE, and/or TIP120A/CAND1. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25354] "Widely expressed by human CUL3 Gene (Cullin Family), 768-aa 89-kDa neddylated nuclear and Golgi-associated Cullin 3 is involved in ubiquitination of cyclin E and perhaps cyclin D1 in regulation of G1/S transition. CUL3 interacts with RBX1, RNF7, CYCE and TIP120A/CAND1. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25355] "Encoded by human CUL4a Gene (Cullin Family), 659-aa 77-kDa neddylated Cullin 4 is involved in the third step of ubiquitin conjugation and proteasomal degradation of target proteins. CUL4a interacts with RBX1, RNF7 and TIP120A/CAND1. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25356] "Encoded by human CUL5 Gene (Cullin Family), 780-aa 91-kDa neddylated Cullin 5 is a component of E3 ubiquitin ligase complexes with elongin BC complex and diverse other factors, involved in the third step of ubiquitin conjugation and proteasomal degradation of target proteins. CUL5 interacts with RBX1 and RNF7. Evidence suggests that CUL5 may also form a cell surface vasopressin receptor. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25357] "This protein acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25358] "This protein acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known."                                                                                                                                                                                                                                                                                                                                                           
[25359] "Arginine Vasopressin Receptor 2 is also known as the V2 receptor. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. AVPR2 expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                       
[25360] "Bradykinin Receptor B2, encoded by the BDKRB2 gene, is a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25361] "A cytokine receptor that binds to BLC. Burkitt lymphoma receptor 1 exerts possibly a regulatory function in Burkitt lymphoma lymphomagenesis and/or B-cell differentiation. It is a potential candidate for cell-cell interaction, and activation of mature B- lymphocytes in lymphatic tissues. (Swissprot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25362] "Encoded by human XCR1 Gene (GPCR Family 1), Chemokine (C Motif) XC Receptor 1 is a 333-amino acid 38.5 kD seven transmembrane protein most closely related to RBS11 and MIP1-alpha/RANTES receptor. Strong expression of the receptor for chemokines XCL1 (SCYC1) and XCL2 (SCYC2) occurs in placenta, spleen, and thymus. Cells expressing GPR5 mobilize intracellular calcium and migrate in response to SCYC1 and SCYC2. Migration is suppressed by pertussis toxin, indicating that the receptor is coupled to a G-alpha protein.  (OMIM, Swiss-Prot, LocusLink, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                      
[25363] "Colony Stimulating Factor 2 Receptor, Beta, Low-Affinity (CSF2RB), encoded by the CSF2RB gene, is a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defective CSF2RB has been reported to be associated with protein alveolar proteinosis. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25364] "Expressed in platelets and vascular endothelia by human F2R Gene (GPCR1 Family), 425-aa 47-kDa (precursor) Coagulation Factor II Receptor is a 7-transmembrane G-protein coupled high affinity activated thrombin receptor that stimulates phosphoinositide hydrolysis in the cellular thrombotic response. F2R appears to play a role in platelet activation and vascular development. Receptor phosphorylation probably mediates desenzitization prior to uncoupling and internalization. Activated protein C uses EPCR as a coreceptor for cleavage of Coagulation Factor II Receptor on endothelia. Proteolytic cleavage of F2R generates a new N-terminus that functions as a tethered ligand. (NCI)"                                                                                                                                                                                                                                                                                          
[25365] "Acts as an adaptor protein, interacting with FAS or TNFR-2. The death domain of these receptors binds to the corresponding domain of FADD, which in turn recruits the zymogen form of the death protease FLICE, activating a protease cascade which results in apoptosis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25366] "Deleted in Malignant Brain Tumors 1, encoded by the human DMBT1 gene, is a member of the scavenger-receptor superfamily and likely a truncated form of a receptor for SFTPD. This 340 kD protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Binding between GP340 and SFTPD is a protein-protein interaction and the binding to GP340 takes place via the carbohydrate recognition domain of SFTPD. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. Transcript variant 2 (8.0 kb) binds surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may play a role in the interaction of tumor cells and the immune system. (From LocusLink, OMIM and NCI)"                                                                           
[25367] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25368] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25369] "Methyltransferase Genes encode Methyltransferases, a subclass of transferase class enzymes that catalyze the transfer of a methyl group from one compound to another. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25370] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25371] "DNA Methyltransferase 3B, encoded by the human DNMT3B gene, is required for genome wide de novo methylation and is essential for development. This nuclear protein interacts with UBL1 and UBE2I9. Six isoforms (1, 2, 3, 4, 5 and 6) are produced by alternative splicing but isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate. Defects in DNMT3B are a cause of immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. ICF is biochemically characterized by hypomethylation of CpG sites in some regions of heterochromatin. (From LocusLink, Swiss-Prot and NCI)"                                                                                    
[25372] "Ubiquitous 126-aa 13-kDa Tumor Suppressor Deleted In Oral Cancer-Related 1 protein is encoded by human DOC-1R Gene (DOC1 Family). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25373] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25374] "Endocytosis of particulate material, such as microorganisms or cell fragments, into membranous phagosomes that fuse with lysosmes and result in digestion of the ingested material. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25375] "Dedicator of Cyto-Kinesis 1, encoded by the human DOCK1 gene, binds to the SH3 domain of CRK protein and may be involved in integrin signaling. It may regulate cell surface extension. During programmed cell death (apoptosis), cell corpses are rapidly engulfed. This engulfment process involves the recognition and subsequent phagocytosis of cell corpses by engulfing cells. This protein may function in the cell surface extension of an engulfing cell around a dying cell during apoptosis. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25376] "Docking Protein 1, encoded by the human DOK1 gene, interacts with receptor tyrosine kinases and mediates particular biological responses. This 62-kD protein is associated with p120 Ras-GAP and this association is correlated with its tyrosine phosphorylation. It is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. It plays an important role in mitogenic signaling and its aberrant phosphorylation may contribute to the progression of different human diseases. It is phosphorylated by the insulin receptor kinase, resulting in the negative regulation of the insulin signaling pathway. (From LocusLink, Swiss-Prot, OMIM and NCI)"                                                                                                                                  
[25377] "Phosphotyrosine binding (PTB) domains are 100-150 residue modules that commonly bind Asn-Pro-X-Tyr motifs. The PTB domains of the docking proteins Shc and IRS-1 require ligand phosphorylation on the tyrosine residue (NPXpY) for binding. More N-terminal sequences are also required for high affinity binding and conferring specificity. The peptide binds as a b-strand to an anti-parallel b-sheet, while the NPXpY motif makes a turn, positioning the pY for recognition by basic residues. The PTB domains of proteins such as X11, Dab, Fe65 and Numb apparently recognize NPXY or related peptide motifs, but are not dependent on ligand phosphorylation. In addition, the Numb PTB domain can bind an unrelated peptide that forms a helical turn.(www.mshri.on.ca/pawson)"                                                                                                                                                                                                          
[25378] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25379] "Dopamine Receptor D1, encoded by the human DRD1 gene, is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. It regulates neuronal growth and development, mediates some behavioral responses, and modulates dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25380] "Dopamine Receptor D4, encoded by the human DRD4 gene, is a G-protein coupled receptor that inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. DRD4 is one of the most variable human genes known. Most of this diversity is the result of length and single-nucleotide polymorphism (SNP) variation in a 48-bp VNTR in exon 3, which encodes the third intracellular loop of this dopamine receptor. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                                                      
[25381] "Dopamine Receptor D5, encoded by the human DRD5 gene, is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. This receptor complexes selectively with GABA-A ligand-gated channel through the direct binding of its carboxy-terminal domain with the second intracellular loop of the GABA-A gamma-2 (short) receptor subunit. This physical association enables mutual inhibitory functional interactions between these receptor systems. Pseudogenes related to this gene reside on chromosomes 1 and 2. Defects in DRD5 are a cause of blepharospasm, a primary focal dystonia affecting the orbicularis oculi muscles, usually beginning in middle age. (From LocusLink, Swiss-Prot, OMIM and NCI)"                                                                                                                                    
[25382] "Diphtheria Toxin Receptor, encoded by the human DTR gene, is a heparin-binding EGF-like growth factor. It is mitogenic for fibroblasts and smooth muscle and may be involved in macrophage-mediated cellular proliferation. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. This mature type I membrane protein is released into the extracellular space and probably binds to a receptor. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25383] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25384] "Encoded by human FGF10 Gene (FGF Family), secreted 208-aa 23-kDa (precursor) Fibroblast Growth Factor 10 contains 2 putative N-glycosylation sites, a heparin binding domain, and several putative phosphorylation sites and is involved in epidermal brain, lung, and limb bud morphogenesis. Most similar to FGF7, FGF10 is mitogenic in the lung and for keratinizing epidermal cells. FGF10 also appears to be involved tissue repair/wound healing. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25385] "Expressed in brain by human FGF20 Gene (FGF Family), 211-aa 23.5-kDa Fibroblast Growth Factor 20 contains a strong hydrophobic region in its FGF core domain and a weak hydrophobic N terminal region. FGF20 may enhance the survival of midbrain dopaminergic neurons. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25386] "Fibroblast Growth Factor 21 (209-aa 22-kDa precursor) is encoded by human FGF21 Gene (FGF Family). FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25387] "Encoded by human FG8F Gene (FGF Family), alternative isoforms FGF-8A, FGF-8B, FGF-8E, and FGF-8F of secreted autocrine androgen-induced Fibroblast Growth Factor 8 may be involved in angiogensis and/or act as an embryonic epithelial factor in midbrain and limb development, in organogenesis, in gastrulation, and in left-right axis determination. Additional isoforms may exist. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25388] "Expressed in brain, kidney, testis, and widely in fetal tissues by human FGFR3 Gene (FGFR Family), 3 alternative isoforms of highly conserved type I membrane protein Fibroblast Growth Factor Receptor 3, consisting of an acidic- and basic-FGF binding extracellular region (containing 3 Ig C2-type domains), a transmembrane segment, and a cytoplasmic tyrosine kinase domain, activate downstream signal cascades involved in mitogenesis and differentiation, as well as bone development and maintenance. FGFR3 defects cause achondroplasia, crouzon syndrome, thanatophoric dysplasia, coronal synostosis, hypochondroplasia, bladder and cervix cancers. (NCI)"                                                                                                                                                                                                                                                                                                                         
[25389] "Endometrial Bleeding Associated Factor, encoded by the human EBAF gene, is a member of the TGF-beta family of proteins. This protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. It is transiently expressed before and during menstrual bleeding and may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                  
[25390] "A class of genes that encode cell surface proteins that bind to extracellular polypepetide molecules triggering intracellular signaling pathways that activate various cellular responses such as cell proliferation and/or differentiation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25391] "Encoded by human FGFRL1 Gene (FGFR Family), at 504-aa 54.6-kDa conserved Fibroblast Growth Factor Receptor-Like 1 consists of an extracellular region (containing 3 Ig-like domains), a hydrophobic transmembrane segment, and a cytoplasmic tail lacking a tyrosine kinase domain. This protein may interact with other family members and inhibit growth factor signaling. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25392] "Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas by human FASTK Gene (Ser/Thr PK Family), 3 alternative isoforms of 549-aa 61-kD Fas-Activated Serine/Threonine Kinase are rapidly activated during Fas-mediated apoptosis as serine/threonine dephosphorylated FASTK, which phosphorylates TIA1, a key apoptosis-promoting nuclear RNA-binding protein. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25393] "Encoded by human GLMN Gene, two alternative isoforms of ubiquitous monomeric Glomulin interact with immunophilins FKBP59, FKBPP52, and FKBP12 that bind the macrolide immunosuppressants FK506 and rapamycin. A possible membrane anchoring protein, Glomulin may couple hepatocyte growth factor receptor signaling to the p70 S6 protein kinase pathway. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25394] "Expressed in testis, thymus, and lymphoblasts by human FANCG Gene, 622-aa 68.5-kD DNA Repair Protein XRCC9 contains an N-terminal leucine-zipper motif and belongs to a multisubunit nuclear protein complex with PHF9, FANCA, FANCC, FANCE, and FANCF. Implicated in interstrand DNA cross-link repair and in maintenance of normal chromosome stability, FANCG may operate in postreplication repair or in a cell cycle checkpoint. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25395] "Encoded by human EXTL1 Gene (EXT Family), 676-aa 75-kDa Exostosin-Like 1 is a type II membrane protein glycosyltransferase of the endoplasmic reticulum with strong sequence similarity to EXT1 and EXT2 and likely involved in chain elongation during heparan sulfate and heparin biosynthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25396] "Ubiquitously expressed by human EXTL2 Gene (EXT Family), 330-aa 37.5-kDa Exostosin-Like 2 is a type II membrane protein glycosyltransferase of the endoplasmic reticulum that initiates heparan sulfate/heparin biosynthesis by alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate and heparin chains. A soluble EXTL2 form, derived from proteolytic processing of the membrane form, is found in serum. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25397] "Ubiquitously expressed by human EXTL3 Gene (EXT Family), 919-aa 105-kDa Exostosin-Like 3 is a type II membrane protein glycosyltransferase of the endoplasmic reticulum likely involved in chain initiation and elongation during heparan sulfate/heparin biosynthesis. EXTL3 contains a highly conserved C-terminal region, common to other EXT proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25398] "The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25399] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25400] "This protein is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. (LocusLink)"                                                                                                                                
[25401] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25402] "Deltex Homolog 1, encoded by the human DTX1 gene, is a transcription corepressor. Notch1 activates CSL by displacing corerepssors and recruiting coactivator. The N terminus of Deltex Homolog 1 directly interacts with the Notch1 ankyrin repeats, and specifically prevents the recruitment of coactivators and limits CSL activation below the threshold needed for induction of T cell fate. Deltex Homolog 1 may also actively promote B cell fate in common lymphoid progenitors. This protein is expressed in T lymphocytes at all stages of development. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                   
[25403] "Encoded by human BAG5 Gene (BAG1 Family), 447-aa 52-kD BCL2-associated Athanogene 5 contains 4 bag domains and, bound to HSP70/HSC ATPase domains, inhibits HSP70/HSC70 chaperone activity by promoting substrate release. A BAG domain near the C-terminus may bind HSC70/HSP70. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25404] "BAI1 is a a seven-span transmembrane protein and is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                           
[25405] "Expressed in glia and neurons by human FGF9 Gene (FGF family), 208-aa 23-kDa (precursor) N-glycosylated monomeric secreted Fibroblast Growth Factor 9 has glial growth-stimulating effects and is likely involved in glial cell growth and differentiation, gliosis, and differentiation or survival of neuronal cells. Three molecular species of 30-kDa, 29-kDa and 25-kDa, cleaved at Leu-4, Val-13 and Ser-34 respectively, are found. Expression may be dependent on Sonic hedgehog signaling. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25406] "Genes that encode the class of enzymes that catalyze the transfer of glycosyl groups to an acceptor; often another carbohydrate molecule, a protein, or inorganic phosphate. Some enzymes in this class catalyze hydrolysis - the transfer of a glycosyl group to water. Subclasses include Hexosyltransferases, Pentosyltransferases, and Sialyltransferases. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25407] "Endothelial Cell Growth Factor 1 (Platelet-Derived), encoded by the human ECGF1 gene, catalyses the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. This protein may have a role in maintaining the integrity of the blood vessels. It promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting only on endothelial cells. It also limits glial cell proliferation as gliostatin. Defects in ECGF1 are the cause of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), an autosomal recessive human disease associated with multiple deletions of skeletal muscle mitochondrial DNA (MTDNA). (From LocusLink, Swiss-Prot and NCI)"                                                                                                                 
[25408] "B-Cell Lymphoma 6 Protein is a zinc finger transcription factor containing an N-terminal POZ domain. It acts as a sequence-specific repressor of transcription and its activity is dependent upon DNA-binding and on the N-terminal region containing the POZ motif. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. Target genes have roles in B-cell activation, B-cell differentiation, inflammation, and cell cycle control. Expression of BCL6 in some B-cells early in the antigen response may skew them toward a germinal center fate, away from a plasma cell fate. The BCL6 gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. (from OMIM, LocusLink and NCI)"                                                                                                                                                         
[25409] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25410] "Endothelin-2, encoded by the human EDN2 gene, is a macrophage chemoattractant. Endothelins are endothelium-derived vasoconstrictor peptides. The expression of this secreted protein by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25411] "The gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. (LocusLink)"                                                                                                                                                                                                            
[25412] "Epidermal Growth Factor-Like Protein 6, encoded by the human EGFL6 gene, is a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. This glycoprotein contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an Arg-Gly-Asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                        
[25413] "ETS Homologous Factor, encoded by the human EHF gene, is a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). This protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. Dot blot analysis detects high levels of EHF expression in salivary gland, prostate, and trachea, with lower levels detected in colon, mammary gland, pancreas, lung, stomach, appendix, fetal kidney, and fetal lung. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                          
[25414] "EphA2 is overexpressed in many cancers, including 40% of breast cancers.  EphA2 can also transform breast epithelial cells in vitro to display properties commonly associated with the development of metastasis. (from Microsc Res Tech 2002 Oct 1;59(1):58-67)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25415] "Elastin Microfibril Interface Located Protein, encoded by the human EMILIN gene, is an extracellular matrix glycoprotein found between amorphous elastin and microfibrils. This protein may play a role in elastin deposition. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25416] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25417] "Eph-related receptor tyrosine kinase A4.  Semms to have a function in axon guiding and development of the corticospinal tract. (LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25418] "This protein functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25419] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25420] "Eph-related receptor tyrosine kinase B1; may have a role in neurogenesis (Proteome Summary, from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25421] "Frizzled 2, encoded by the human FZD2 gene, is a 7-transmembrane domain protein that is a receptor with a role in transmembrane signal transmission for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25422] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25423] "Frizzled 3, encoded by the human FZD3 gene, is a G protein-coupled receptor for Wnt proteins and regulates signal transduction in endothelial cells via beta-catenin. It may function in both normal and pathological vasculature differentiation. It also may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Two isoforms are produced by alternative splicing. This protein is widely expressed with relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                              
[25424] "Eph-related receptor tyrosine kinase B2; may have a role in neurogenesis (Proteome Summary, from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25425] "Frizzled 4, encoded by the human FZD4 gene, is a G protein-coupled receptor that has seven transmembrane domains. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. It may function in cell polarity, cell fate specification and cancer. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25426] "Eph-related receptor tyrosine kinase B3; may have a role in cell migration in the gut."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25427] "Implies movement of a population of cells from one place to another as in the movement of neural crest cells during morphogenesis. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25428] "A class of agents used in prophylactic or curative therapy to attenuate the negative side effects of toxins or drugs.  Protective agents belong to various chemical classes, acting through various pharmacological mechanisms.  They may neutralize exogenous poisons, coat mucosa for protection against physical or chemical damage, offer antioxidant protection against free radicals or ionizing radiation, or induce endogenous detoxifying enzymes. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25429] "Epiregulin is a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. Epiregulin functions as a tumor growth-inhibitory factor in HeLa cells. (LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25430] "Frizzled 7, encoded by the human FZD7 gene, is a G protein-coupled receptor for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression downregulates APC function and enhances beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25431] "Ets2 repressor factor, a transcriptional repressor; suppresses ets-induced transformation; contain an Ets-domain (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25432] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25433] "ERBB2 interacting protein; acts as an adaptor for the receptor ERBB2/HER2, which may assist in their localization and signalling function; has a PDZ domain and sixteen leucine-rich repeats (LRRs) (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25434] "DNA-binding protein of the ETS family; contains a DNA binding domain (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25435] "Member of the ets DNA binding protein family; may bind the adenovirus E1A enhancer. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25436] "Epidermal growth factor receptor pathway substrate 8; has a role in normal and neoplastic cell proliferation; contains an SH3 motif. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25437] "Epidermal growth factor receptor pathway substrate 15; has a role in normal and neoplastic cell proliferation. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25438] "Frizzled 6, encoded by the human FZD6 gene, is a G protein-coupled receptor for Wnt signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other Fz family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif. Frizzled 6 may function in tissue polarity, development and carcinogenesis. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25439] "Gastric inhibitory polypeptide (glucose-dependent insulinotropic polypeptide) receptor; signals through stimulatory G-protein to increase intracellular cAMP; member of the G protein-coupled receptor family. (Proteome Summary from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25440] "G Protein-Coupled Receptor Kinase-Interactor 1: GIT1 is a multidomain protein that is thought to function as an integrator of signaling pathways controlling vesicle trafficking, adhesion and cytoskeletal organization. (from J Cell Sci 2002 Apr 1;115(Pt 7):1497-510)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25441] "This protein is a member of the GIT protein family. GIT proteins interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. The gene undergoes extensive alternative splicing. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25442] "Frizzled 9, encoded by the human FZD9 gene, is a G protein-coupled receptor for Wnt signaling proteins. This gene has been first described as FZD3 in literature. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. Frizzled 9 may function in tissue polarity, development and carcinogenesis. Heterozygous deletion of the FZD3 gene may contribute to the Williams syndrome phenotype. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25443] "Guanine nucleotide binding protein is a member of a G protein subfamily that mediates signal transduction; component of pertussis toxin-insensitive (PTX) heterotrimeric G-protein complexes. The protein differs strikingly from other G-alpha subunits in amino acid sequence in a number of regions, and it appeared to be highly enriched in neural tissue. (LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25444] "Encoded by human GNA12 Gene (G-Alpha 4 (G(12)) Family), 380-aa 44-kDa membrane-bound Guanine Nucleotide Binding Protein Alpha 12 is a G protein alpha subunit that contains a guanine nucleotide binding site and is involved in transmembrane signaling. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25445] "Encoded by single copy human GNAI2 Gene (G-Alpha 1 Family), 354-aa 40-kDa G(i) Alpha 2 Protein is a guanine nucleotide-binding alpha protein subunit of heterotrimeric G protein transducers (alpha, beta, gamma) in transmembrane signaling systems involved in hormonal regulation of adenylate cyclase. Containing virtually identical/similar beta and gamma chains, G proteins are most distinguished by alpha chains. G(i) proteins (alpha(i) subunit) inhibit cyclase in response to beta-adrenergic stimuli. Specific alpha chain regions appear to interact with guanine nucleotides, receptors, effector enzymes, and G protein beta-gamma complex. G proteins that inhibit adenylate kinase are substrates for pertussis toxin. GNAI2 mutations affect cell proliferation. (NCI)"                                                                                                                                                                                                        
[25446] "Heterotrimeric G Protein Subunit Genes encode Heterotrimeric G Protein signal transducers, attached to the plasma membrane, that connect seven transmembrane cell surface G-protein coupled receptors to intracellular signal transduction effectors and pathways. Inactive G proteins consist of alpha/beta/gamma complexes that signal as dissociated GTP-bound alpha subunit or the beta/gamma complex. GTP hydrolysis by the inherent GTPase reverts the alpha subunit to its inactive (heterotrimeric) form. Receptors coupled to G proteins communicate signals from hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. (NCI)"                                                                                                                                                                                                                                                                                                                                     
[25447] "GRB2-Associated Binding Protein 2 (GAB2), encoded by the human GAB2 gene, is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Upon tyrosine phosphorylation, GAB2 interacts with SHP2 tyrosine phosphatase and GRB2 adapter protein. It is the limiting component of the GAB2-SHP2 complex, signaling Erk MAP kinase activation and terminal differentiation of K562 CML cells. GAB2 also has an inhibitory effect on the activation of ELK1-dependent transcription triggered by a dominant active Ras mutant or under growth factor stimulation. Two alternatively spliced transcripts encode different isoforms and the short isoform is the main isoform. This protein is overexpressed and estrogen regulated in human breast cancer. (From LocusLink, OMIM and NCI)"                                                                                                                                                     
[25448] "Encoded by human GNB1 Gene, Guanine Nucleotide Binding Protein Beta 1 is a heterotrimeric G protein beta subunit that regulates G protein alpha subunits and integrates signals between receptors and effector proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25449] "Expressed in oocytes and blastocysts by human GNB2 Gene, 340-aa 37-kDa Guanine Nucleotide Binding Protein Beta 2 is a heterotrimeric G protein beta subunit with 7 WD repeats and involved in transmembrane signaling as a transducer that regulates G protein alpha subunits and integrates signals between receptors and effector proteins. The G protein beta and gamma subunits are required for GTPase activity, for GTP replacement of GDP, and for G protein/effector interaction. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25450] "Encoded by human GNB3 Gene, 340-aa 37-kDa Guanine Nucleotide Binding Protein Beta 3 is a heterotrimeric G protein beta subunit with 7 WD repeats and involved in transmembrane signaling as a transducer that regulates G protein alpha subunits and integrates signals between receptors and effector proteins. The G protein beta and gamma subunits are required for GTPase activity, for GTP replacement of GDP, and for G protein/effector interaction. A splicing polymorphism is associated with essential hypertension and obesity.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25451] "Expressed as 2.3-/6.3-kb mRNAs in brain by human GPR17 Gene (GPCR1 Family), alternative isoforms 1 and 2 of 339-/367-aa 41-kDa integral membrane protein G Protein-Coupled Receptor 17 are a putative purine receptor containing 7 transmembrane domains that transduces extracellular signals through heterotrimeric G proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25452] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25453] "Members of the four-and-a-half-LIM domain (FHL) protein family, which are expressed in a tissue- and stage-specific manner, have been reported to function as transcriptional coactivators. Expression of DRAL (FHL2) results in enhancement of NF-kappaB activation.  DRAL (FHL2) is a p53-responsive gene implicated in induction of apoptosis.  DRAL may participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappaB transcription factor. (from J Biol Chem 2002;277:37045-53 and FEBS Lett 2002;521(1-3):165-9)"                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25454] "Proteins (repressors or activators) which regulate the genetic transcription of the structural genes and/or regulatory genes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25455] "Glioma Amplified on Chromosome 1 Protein, encoded by the human GAC1 gene, belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. GAC1 has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25456] "Acidic fibroblast growth factor intracellular binding protein; may mediate the mitogenic properties associated with acidic FGF1. (Proteome Summary from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25457] "Fms-related receptor tyrosine kinase; growth factor receptor for hematopoietic stem and progenitor cells. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25458] "A type I membrane protein tyrosine kinase receptor for VEGF-C, vascular endothelial growth factor receptor 3, contains seven immunoglobulin-like C2-type domains.  Vascular endothelial growth factors, working through VEGF receptor-3, promote angiogenesis and metastatic spread of cancer cells.  (from Nat Med 2001. 7:151 & 186)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25459] "G Protein-Coupled Receptor 2, encoded by the GPR2 gene, is the receptor for CCL27. The interactions between this receptor and CCL27 are involved in T cell-mediated skin inflammation. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25460] "Encoded by human GPR32 Gene (GPCR1 Family), 356-aa 40-kDa integral membrane protein G Protein-Coupled Receptor 32 is an orphan receptor with greatest similarity to chemoattractant receptors, particularly the formylpeptide receptor (FPR1). (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25461] "Expressed in spleen, testis, peripheral leukocytes, brain, lung, and placenta by GPR68 Gene (GPCR1 Family), 365-aa 41-kDa 7-transmembrane G Protein-Coupled Receptor 68 is a high affinity receptor for sphingosylphosphorylcholine that acts as a proton-sensing receptor and stimulates PI hydrolysis. The receptor is inactive at pH 7.8 and fully activated at pH 6.8; extracellular histidines are involved in pH sensing. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25462] "Encoded by human FOXO1A Gene (Forkhead Family), ubiquitous 655-aa 70-kDa Forkhead Box O1A is a probable nuclear transcription factor (phosphorylated by AKT1; insulin-induced) that contains 1 forkhead domain and may play a role in myogenic growth and differentiation. Translocations of the FOXO1A gene - t(2;13)(q35;q14) or t(1;13)(p36;q14) - are associated with alveolar rhabdomyosarcoma-2 that produce FOXO1A/PAX3 and FOXO1A/PAX7 transcriptional activators. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25463] "Expressed in neutrophils by human FPR1 Gene (GPCR1 Family), 350-aa 38-kDa Formyl Peptide Receptor 1 is a high affinity integral membrane protein GPCR (activates a PI-calcium second messenger system) for N-Formyl-Methionyl peptides, which are powerful chemotactic and activation factors for neutrophils.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25464] "Up-regulated by chronic inflammation and encoded by human CX3CR1 Gene (CCR Family, Rhodopsin Family), 355-amino acid 40.4-kD high-affinity Fractalkine Receptor is a seven transmembrane protein expressed in brain, peripheral blood leukocytes, and spleen as a regulator of leukocyte endothelial trafficking: chemotaxis, cell migration, and adhesion. CX3CR1 signals through a pertussis toxin sensitive G-protein to induce migration and contains common GPCR features. Tyrosine sulfation enhances fractalkine-induced cell adhesion. Sharing the CX3C motif, RSV G glycoprotein can use CX3CR1 as a receptor. CX3CR1 may be an HIV envelope protein co-receptor with CD4. Homozygous CX3CR1 I249/M280 haplotype enhances infection and progression to AIDS. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                  
[25465] "Encoded by human tumor suppressor DAB2 Gene, Disabled Homolog 2 Protein is expressed in ovarian, breast, and lung epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, placenta, brainstem, heart, and small intestine. The 770-amino acid 82.5-kD predicted protein has 83% identity with mouse p96 protein, a putative mitogen-responsive phosphoprotein; strongest homology exists in the N-terminal PTB/PID domain. Potentially phosphorylated, DAB2 is a putative component of the CSF-1 cell proliferation signal transduction pathway.  (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                
[25466] "Encoded by human DDR2 Gene (InRTK Subfamily) and expressed in heart, lung, brain, placenta, liver, skeletal muscle, pancreas, and kidney, 855-amino acid 96.8-kD precursor Discoidin Domain Receptor 2 is a receptor tyrosine kinase for fibrillar collagen involved in cell adhesion. Mediating fibroblast migration and proliferation, the type I membrane protein contains an intracellular catalytic domain and extracellular coagulation factor 5/8 type C and discoidin domains. RTKs often transduce signals by ligand induced receptor oligomerization, intracellular autophosphorylation, and phosphorylation of cytosolic targets. DDR2 may contribute to cutaneous wound healing. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                           
[25467] "Encoded by human DDX1 Gene and highly expressed in neuroectodermal tissues, 740-amino acid 82.4-kD DEAD/H Box Protein 1 has unknown function, contains a SPRY domain, and belongs to the DEAD/H box ATP-dependent RNA helicase family. DEAD box proteins, characterized by the conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                  
[25468] "Encoded by human DDX16 Gene (DEAD/H Subfamily, member 16), ubiquitous 1041-amino acid 119.3-kD nuclear DEAD/H Box Protein 16 is a functional homolog of the Prp8/cdc28 cell cycle progression protein (S. pombe), similar to DEAH box proteins that act as splicing factors. DBP2 is a probable ATP-binding RNA helicase involved in pre-mRNA splicing. DEAD box proteins, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                   
[25469] "Encoded by human DEC1 Gene, widely expressed 70-amino acid DEC1 Protein is a candidate tumor suppressor protein of unknown function; possibly negative regulation of cell proliferation. (from LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25470] "Encoded by human DEFB1 Gene (Beta-Defensin Family), Beta-Defensin 1 Protein prepropeptide contains a 68-amino acid secreted antimicrobial plasma peptide implicated in cystic fibrosis pathogenesis. Multiple plasma forms are bound to carrier macromolecules. Highest DEFB1 concentrations occur in kidney and female reproductive tract epithelia. DEFB1 may act in innate immunity. Mammalian alpha- and beta-defensins comprise 3.5- to 5-kD cysteine- and arginine-rich neutrophilic microbicidal and cytotoxic peptides. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                        
[25471] "Encoded by human DEK Gene, ubiquitous 375-amino acid 43-kD nuclear RNA- and DNA-binding DEK Protein contains a SAP domain and appears to be involved in transcriptional regulation and signal transduction. Most is associated with chromatin, a fraction with RNA. The amount and localization does not change during the cell cycle. DEK binds the HIV-2 'pets' site, interacts with histones, DAXX, and HDAC2, and induces superhelical chromatin alterations with TOP1 or TOP2A. It does not induce histone displacement, but changes nucleosomal DNA topology, and reduces replication efficiency. DEK is a spliced exon-associated spliceosome component mediated by SR protein interactions, such as SRM160. AML-associated t(6;9)(p23;q34) creates fused DEK to CAN with no ORF interruption. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                  
[25472] "Encoded by human DLEC1 Gene, 1755-amino acid 195.8-kD DLEC1 Protein is a putative negative regulator of cell proliferation. DLC1 appears to suppress the growth of some cancer cell lines. Aberrant expression may be involved in carcinogenesis of the lung, esophagus, and kidney. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25473] "Expressed in testis, thymus, small intestine, prostate, spleen, peripheral blood lymphocytes, and ovary and encoded by human DLEU1 Gene, DLEU1 Protein is a 72-amino acid putative tumor suppressor protein for BCLL. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25474] "Expressed in thymus and testis and encoded by human DLEU2 Gene, DLEU2 Protein is an 84-amino acid 10-kD putative tumor suppressor protein. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25475] "This protein is a member of the GRB2/Sem5/Drk family. It functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. Expression is restricted to lymphoid tissues.(LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25476] "GRB2 forms a complex with activated EGFR and the RAS-specific guanine nucleotide exchange factor SOS1, thereby mediating the growth factor-induced activation of RAS. It also acts to link PDGFRB to the Rac signaling pathway. Due to its ability to cause complex formation between proteins involved in growth signaling pathways, GRB2 has been referred to as an adaptor protein. (from LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25477] "Grb7 is the prototype of a family of adaptor molecules that also include Grb10 and Grb14 that share a conserved molecular architecture including Src homology 2 (SH2) and pleckstrin homology (PH) domains. It is an adapter-type signaling protein, which is recruited via its SH2 domain to a variety of receptor tyrosine kinases (RTKs), including ErbB2 and ErbB3. Grb7 has been implicated as a downstream mediator of integrin-FAK signal pathways in the regulation of cell migration, although the molecular mechanisms are still not well understood. It is overexpressed in breast, esophageal, and gastric cancers, and may contribute to the invasive potential of cancer cells.(from J Biol Chem 2002;277:29069-77 and J Biol Chem 2002;277:11918-26)"                                                                                                                                                                                                                                
[25478] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25479] "CD183 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to CD183. A hallmark of CD183 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that CD183 and its chemokines participate in the recruitment of inflammatory cells. (from LocusLink)"                                                                                  
[25480] "Grb10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules.  It interacts with IGF1R, PDGFRB, and EGFR and binds to the Raf-1 and MEK1 kinases. Its cellular role is still unclear and a positive as well as an inhibitory role in mitogenesis depending on the cell context has been implicated.  Grb10 may regulate signaling between plasma membrane receptors and the apoptosis-inducing machinery on the mitochondrial outer membrane. (from LocusLink, J Biol Chem 1999;274:35719-24, and Mol Cell Biol 1999;19:6217-28)"                                                                                                                                                                                                                                                                                                                                                                              
[25481] "Expressed in stomach, kidney, liver, lung, pancreas, central nervous system, and prostate by human GPRC5C Gene (GPCRc Family), 441-aa 48-kDa 7-transmembrane G Protein-Coupled Receptor Family C Group 5 Member C has an extracellular N-terminal domain, an intracellular C-terminal domain, and conserved cysteines residues. The specific protein function is unknown; it may mediate retinoic acid effects on G protein signal transduction. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25482] "Member of the GRB7 family of adapter proteins; identified as a partner of the insulin receptor where it acts as a modulator of insulin signaling. (from J Biol Chem 2002;277:4845-52)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25483] "A class of signaling pathway proteins that function to mediate the coupling of multiple cell surface receptors to downstream signaling pathways in the regulation of various cellular functions. (from Oncogene 2001;20:6315-21)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25484] "Expressed primarily in testis and brain by human GPRK2L Gene (GPRK Family), one of 4 alternative isoforms (GRK4A, B, C, D) of 578-/546-/532-aa 67-kDa G Protein-Coupled Receptor Kinase 2-Like is a Ser/Thr kinase containing an RGS domain that phosphorylates activated GPCRs and may play a role in receptor desensitization. Only full-length GRK4D has kinase activity, can phosphorylate rhodopsin, and is inhibited by calmodulin. The other isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25485] "G protein-coupled receptor kinases regulate G protein-coupled receptors through phosphorylation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25486] "G Protein-Coupled Receptor Kinase Genes encode G Protein-Coupled Receptor Kinases, which regulate through phosphorylation the signaling function of G protein-coupled receptors and signal transduction. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25487] "Expressed in heart, placenta, lung, skeletal muscle, brain, liver, pancreas, and kidney by human GPRK5 Gene (GPRK Family), 590-aa 68-kDa G Protein-Coupled Receptor Kinase 5 contains an RGS domain and specifically Ser/Thr phosphorylates and regulates activated forms of GPCRs. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25488] "Ubiquitously expressed by human GRF2 Gene (as at least 2 alternative isoforms), Guanine Nucleotide-Releasing Factor-2 is an adaptor-type Ras-GEF/SH2-domain protein involved in signal transmission from cell surface to the nucleus. GRF2 binds to CRK and GRB2/ASH SH3 domains and transduces signals to activate RAS. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25489] "Widely expressed by human GPRK6 Gene (GPRK Family), alternative isoforms A (576-aa) and B (589-aa) of membrane-bound 66-kDa G Protein-Coupled Receptor Kinase 6, containing an RGS domain and DLG and ENIL motifs, specifically Ser/Thr phosphorylate activated forms of GPCRs and may be involved in desensitization of D2/D3 dopamine receptors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25490] "Subunit 3 of the AMPA subtype of ionotropic glutamate receptor; important for excitatory neurotransmission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25491] "L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of the GRM1 gene have been described but their full-length nature has not been determined. (LocusLink)"           
[25492] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25493] "The metabotropic glutamate receptors are a family of G protein-coupled neurotransmitter receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties; activates phospholipase C and calcium-induced chloride channels (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25494] "Expressed in retina by human GPRK7 Gene (GPRK family), membrane-bound 553-aa 62-kDa G Protein-Coupled Receptor Kinase 7 is a Ser/Thr kinase containing an RGS domain, a C-terminal CaaX motif for isoprenylation and carboxymethylation, an autophosphorylation site (Ser491), and a geranylgeranylation motif. GRK7 catalyzes rhodopsin phosphorylation, initiating their deactivation in a light-dependent manner. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25495] "The metabotropic glutamate receptors are a family of G protein-coupled neurotransmitter receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25496] "Glutathione S-transferase theta 1 is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. The theta class includes GSTT1 and GSTT2. In humans, the GSTT1 enzyme is found in the erythrocyte and this may act as a detoxification sink. (LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25497] "HGS is a downstream signaling molecule.  It undergoes tyrosine phosphorylation in response to IL2, CSF2, or HGF."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25498] "Encoded by human GPS1 Gene, 471-aa 53-kDa G Protein Pathway Suppressor 1 Protein contains a PCI domain and has similarity to signal transduction regulator FUS6 (Arabidopsis). GPS1 suppresses G-protein- and MAP kinase-mediated signal transduction. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25499] "Galanin Receptor 2 (GALR2) is encoded by the GALR2 gene. Galanin is an important neuromodulator, a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. Galanin Receptor 2 decreases cAMP through an inhibitory G-protein and stimulates phospholipase C and mobilizes calcium through Gq/G11. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq). (From LocusLink and NCI)"                                                                                                                                                                                                           
[25500] "Encoded by human GPS2 Gene, 2 isoforms of 327-aa 37-kDa G Protein Pathway Suppressor 2 Protein suppress RAS and MAP kinase signal transduction and interfere with c-JNK activation. GPS2 is an integral subunit of NCOR1/HDAC3 complex. GPS2 and TBL1 in NCOR1/HDAC3 interact with NCOR1 repression domain-1 to link to HDAC3 via the NCOR1 SANT domain, which activates HDAC3 activity. NCOR1/HDAC3 inhibits JNK activation through GPS2. GPS also interacts with E2 and E6 proteins. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25501] "Induced in response to several activation signals and encoded by B-cell specific immediate early human RGS1 Gene (RGS Family), 196-aa 22.5-kDa Regulator of G-Protein Signaling 1, containing 1 RGS domain, is likely involved in regulation of B-cell activation and proliferation. Potentially regulated by protein kinase(s), RGS1 inhibits signal transduction by increasing GTPase activity of G protein alpha subunits, driving them into the inactive GDP-bound form.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25502] "Encoded by human RGS2 Gene (RGS Family), 211-aa 24-kDa Regulator of G-Protein Signaling 2 is a basic HLH phosphoprotein containing 1 RGS domain with similarity to lymphocyte-specific 1R20 and phosphorylated by PKC. RGS2 inhibits signal transduction by increasing GTPase activity of G protein alpha subunits, driving them into the inactive GDP-bound form. RGS2 also reduces cAMP production by inhibiting odorant-stimulated Alpha-OLF linked adenylyl cyclase type III activity in olfactory neurons. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25503] "Encoded by human RGS3 Gene (RGS Family), 519-aa 56.6-kDa cytosolic Regulator of G-Protein Signaling 3 contains 1 RGS domain and is likely phosphorylated by cyclic GMP-dependent protein kinase. RGS3 inhibits G-protein mediated signal transduction by increasing G protein alpha subunit GTPase activity, promoting its conversion to the inactive GDP-bound form. G-protein activation leads to translocation of RGS3 to the plasma membrane. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25504] "Expressed most in lung, placenta, liver, and heart by human RGS19 Gene (RGS Family), membrane-bound fatty acylated 217-aa 25-kDa Regulator of G-protein Signaling 19 is a guanosine triphosphatase-activating protein, containing 1 RGS domain, that specifically interacts with G protein GAI3 and down-regulates G Alpha i/G Alpha q-linked signaling. Heavily palmitoylated in the Cys string motif and mainly phosphorylated on Ser residues, RGS19 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, driving them into the inactive GDP-bound form. RGS19 binds to G-Alpha subfamily 1 members and interacts with GIPC PDZ domain. (NCI)"                                                                                                                                                                                                                                                                                                            
[25505] "IGF2R is a 250kDa transmembrane protein. It was originally identified as a receptor for IGFII and M6P-containing proteins (e.g. lysosomal hydrolases). Lysosomal enzymes are sorted to lysosomes via IGF2R either from the Golgi, where the enzymes acquire M6P, or from the extracellular space. The majority of IGF2R molecules are located intracellularly, only 5-10% is present on the cell membrane. IGF2R is also a receptor for TGFbeta latency associated peptide (LAP), proliferin and may bind several molecules independently of M6P, including plasminogen, CD87 or retinoic acid. It is involved in activation of latent TGFbeta.  It is a putative hepatocellular tumor suppressor. (from LocusLink)"                                                                                                                                                                                                                                                                                
[25506] "Widely expressed (not restricted to IL6 responsive cells) by human IL6ST Gene (Type I Cytokine Receptor 2 Family), heterodimeric type I membrane protein (isoform 1) and secreted (isoform 2) Interleukin 6 Signal Transducer contains 5 fibronectin type III domains, an Ig-like C2-type domain, a BOX 1 motif required for JAK interaction/activation, and a WSXWS motif necessary for protein folding, intracellular transport, and cell-surface receptor binding. Part of cytokine receptor complexes, IL6ST is a signal transducer dependent on receptor binding for activation by many cytokines (IL6, CNTF, LIF, IL11, CT1, and OSM) that can utilize gp130 in signal transmission. IL6ST may regulate myocyte apoptosis and have a role in embryonic development. Isoform 2 is an autoantigen in rheumatoid arthritis but it is not specific to RA. (NCI)"                                                                                                                                  
[25507] "The interleukin 2 (IL2) receptor gamma chain (IL2RG), an important signalling component of many interleukin receptors (IL2,IL4,IL7,IL9, and IL15), is thus referred to as the common gamma chain. It is necessary for normal growth and differentiation of T cells, B cells, natural killer cells, glioma cells, and cells of the monocyte lineage.  Mutations in this X-chromosome-linked gene cause X-linked severe combined immunodeficiency (XSCID). (from LocusLink and OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25508] "This protein is the beta subunit of the interleukin 2 receptor and is a type I membrane protein. It is involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. It plays a role in the T cell mediated immune response and is a member of the cytokine receptor family. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25509] "IL4R when complexed with the common gamma chain (IL2RG) serves as the high-affinity interleukin 4 (IL4) receptor. It plays a major role in immunoglobulin E (IgE) production"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25510] "This protein is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. (from LocusLink)"                                                                                                                                                                                                                                                                                                                      
[25511] "This protein belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25512] "This protein is the alpha subunit of the high-affinity receptor for interleukin-11. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25513] "The continent located south of Europe and bordered to the west by the South Atlantic and to the east by the India Ocean."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25514] "The world's largest continent; it occupies the eastern part of the Eurasian landmass and its adjacent islands and is separated from Europe by the Ural Mountains. (American Heritage Online Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25515] "The continent whose boundaries are the Atlantic Ocean in the west, the Arctic Ocean to the north, the Ural Mountains and Ural River in the east, the Caspian Sea, Caucasus mountains and Black Sea in the southeast and the Mediterranean Sea in the south. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25516] "North America is a continent in the western hemisphere of Earth, bordered to the west by the Pacific Ocean, the east by the Atlantic Ocean, the north by the Arctic Ocean, and connected at the south to South America by the Isthmus of Panama."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25517] "Oceania is a term used to refer to Polynesia (including New Zealand), Melanesia (including New Guinea), Micronesia as a whole, and Australia. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25518] "South America is a continent of the western hemisphere with most of its area in the southern hemisphere.  It is situated between the Pacific Ocean and the Atlantic Ocean and is attached at the north to North America by the Isthmus of Panama."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25519] "This protein is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor common gamma chain (IL2RG). It has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). (from LocusLink)"                                                                                                                                                                                                                                                                                                                
[25520] "B-lymphocytes can selectively switch to express different immunoglobulin (Ig) isotypes during the course of an immune response. Selective expression of an Ig isotype is regulated by a sequence-specific rearrangement process that replaces the first active set of Ig heavy-chain (IgH) constant-region exons with one of several other downstream constant-region (CH) genes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25522] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25523] "Interleukin-8 is a member of a family of pro-inflammatory cytokines. The best-characterized activities of IL8 include the chemoattraction and activation of neutrophils. There are two IL8 receptors, type 1 (alpha) and type 2 (beta). The type 1 IL8 receptor binds only IL8, while the type 2 IL8 receptor binds also GRO and NAP-2. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25524] "Glioma-Amplified Sequence-41, encoded by the human GAS41 gene, may be a transcription factor and common binding factor for the TACC family proteins. An increased copy number of this gene is found in glioblastoma multiforme and astrocytoma III, and at a high frequency in astrocytoma grades I and II. The GAS41 gene is the first gene found with increased copy number in low-grade glioma, which provides the first evidence that gene amplification can occur in early tumor development. (From OMIM and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25525] "Interleukin-8 is a member of a family of pro-inflammatory cytokines. The best-characterized activities of IL8 include the chemoattraction and activation of neutrophils. There are two IL8 receptors, type 1 (alpha) and type 2 (beta). The type 1 IL8 receptor binds only IL8, while the type 2 IL8 receptor binds also GRO and NAP-2. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25526] "Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. ILK encodes a predicted 451-amino acid protein, with an apparent molecular weight of 59 kD. The ILK protein is a serine/threonine protein kinase with 4 ankyrin-like repeats. ILK regulates integrin-mediated signal transduction. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25527] "The ING1 protein physically interacts with p53 and appears necessary for the role of p53 in growth inhibition/apoptosis. ING1 shares many biological functions with p53 and has been reported to mediate growth arrest, senescence, apoptosis, anchorage-dependent growth, chemosensitivity, and DNA repair. Some of these functions, such as cell cycle arrest and apoptosis, have been shown to be dependent on the activity of both ING1 and p53 proteins. (from Leuk Res 2002;26:631-5 and Exp Cell Res 2002;279:291-8)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25529] "This protein is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this protein plays a role in skeletal morphogenesis. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25531] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25534] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25535] "Human INHBB Gene at 2cen-q13 encodes the Inhibin Beta B subunit, heterodimerized with the Alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin negatively regulates gonadal stromal cell proliferation, has tumour-suppressor activity, and is a marker for primary as well as recurrent granulosa-cell tumors. Inhibin may be both a growth/differentiation factor and a hormone; gonadal and extragonadal expression can vary severalfold in a tissue-specific fashion. Beta B also forms a homodimer, Activin B, and joins with the Beta A subunit to form heterodimeric Activin AB; Activins stimulate FSH secretion. (NCI)"                                                                                                                                                                                                                                                                                                                                                      
[25536] "Encoded by human HHCM Gene, 467-amino acid 52-kD Hepatocellular Carcinoma Protein HHCM exhibits transforming ability on fibroblasts and liver cells. (from LocusLink, Swiss-Prot, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25537] "Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas, and peripheral leukocytes, human IRAK2 Gene (Pelle Ser/Thr Kinase Family) at 3p25.3 encodes 590-aa 65-kDa Interleukin-1 Receptor-Associated Kinase 2, one of two putative Ser/Thr kinases that rapidly associate with the Interleukin-1 Receptor (IL1R) upon stimulation. IRAK2 interacts with TRAF6 and is required for IL1R-induced NF-Kappa-B activation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25538] "Interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor (TLR, e.g., TLR4; MIM 603030) and IL1R family members, collectively referred to as TIRs. IRAK4 functions in this signal transduction pathway.(supplied by OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25539] "Expressed in human heart, skeletal muscle, and adipose tissue and encoded by insulin-responsive HK2 Gene (Hexokinase Family), outer mitochondrial membrane-bound 917-amino acid 102-kD monomeric Hexokinase 2 promotes glycolysis. HK2 contains glucose- and ATP-binding sites and a hexokinase domain. The C-terminus contains catalytic activity; membrane binding and regulation associate with the N-terminus. Allosterically regulated by product, HK2 converts aldo-/keto-hexoses to hexose-6-phosphate, the first step of many metabolic pathways. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                              
[25540] "Expressed in neutrophils, peripheral blood mononuclear cells, and adipose tissue and encoded by human HM74 Gene (GPCR1 Family, Rhodopsin Family), 387-amino acid 44.5-kD integral membrane Chemokine Receptor HM74 is a putative G protein-coupled receptor, containing a 7-transmembrane receptor domain, similar to orphan receptor GPR31, bradykinin receptor B2, and thrombin receptor F2R. HM74 appears to be a nicotinic acid receptor; binding of nicotinic acid to the mouse ortholog PUMA-G or to HM74 results in G protein-mediated decrease in cAMP levels. PUMA-G mediates anti-lipolytic, lipid-lowering effects of nicotinic acid. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                       
[25541] "IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25542] "Encoded by human HNRPA3 Gene, 379-amino acid 40-kD Heterogeneous Nuclear Ribonucleoprotein A3 is similar to helix destabilizing heterogeneous nuclear ribonucleoprotein A1 (rat) and to heterogeneous ribonucleoproteins (putative components of ribonucleosomes). Containing two RNA recognition motifs (RRM), HNRPA3 belongs to the HNRNP A/B group of basic, GLY-rich proteins. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25543] "Encoded by human HOXA10 Gene (ABD-B Family) and expressed spatially/temporally in posterior domains during genitourinary development, 496- and 494-amino acid 41-kD Homeobox Protein A10 isoforms are inhibitory transcription factors, containing a common DNA-binding homeobox domain, that may regulate morphogenesis and differentiation by providing anterior-posterior positional identity. HOXA10 protein is also expressed in adult endometrium during early pregnancy. Bound to 5-prime AA[AT]TTTTATTAC 3-prime DNA, HOXA10 may mediate progesterone regulation of uterine EP3 and EP4. HOXA10 also appears to regulate hematopoietic lineage commitment. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                     
[25544] "Encoded by human HOXA9 Gene (ABD-B Family), 272-amino acid 30-kD Homeobox Protein A9 isoforms are class I sequence-specific DNA-binding homeobox transcription factors potentially involved in morphogenesis and myeloid differentiation; expression is spatially and temporally regulated during embryonic development. Frameshifted isoform B contains a distinct C-terminus lacking the homeodomain. HOXA9 acts within a developmental regulatory system that provides specific anterior-posterior positional identity to cells. Associated with acute myeloid leukemogenesis, a chimerically fused in-frame nucleoporin NUP98 amino terminal half to HOXA9 may inhibit differentiation or disrupt nucleocytoplasmic transport. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                     
[25545] "Encoded by HOXC6 Gene (ANTP Family), 153- and 235-amino acid (27-kD) Homeobox C6 Protein isoforms are highly conserved sequence-specific DNA-binding homeobox transcription repressors that can cooperate with other HOX proteins and may contribute to the breast cell phenotype through co-operative interactions. As part of a developmental regulatory system that provides anterior-posterior positional identity to cells, HOXC6 may regulate the coordinated expression of multiple genes involved in morphogenesis and differentiation. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                        
[25546] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25547] "With six potential N-glycosylation sites and hydrophobic stretches suggesting a transmembrane protein, ubiquitous 543-amino acid Heparanase, encoded by human HPSE Gene, is an endoglycosidase (beta-glucuronidase) that degrades heparan sulfate and related proteoglycans in the ECM and vascular basal laminar. Heparan sulfate degradation is key in tumor cell and migrating leukocyte extravasation. Heparanase activity is also important in angiogenesis, wound healing, and smooth muscle proliferation. (from LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25548] "Encoded by human HSD17B7 Gene (SDR Family) and expressed in breast, ovaries, pregnant uterus, placenta, testis, thymus, prostate, fetal liver, and some neural tissues, 341-amino acid 38-kD 17-Beta-Hydroxysteroid Dehydrogenase 7 oxidizes or reduces estrogens and androgens. Responsible for biosynthesis of estradiol in the corpus luteum during pregnancy, the membrane-associated phosphorylated enzyme is nearly 75% identical to rodent proteins and contains a short chain dehydrogenase domain. Close to the transmembrane domain, HSD17B7 contains a 28-residue superficial loop: a candidate prolactin receptor (PRLR)-binding domain. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                   
[25549] "Encoded by human HTATIP2 Gene (SDR Family), the ubiquitous 242-amino acid 30-kD TAT-Interacting Protein TIP30 is a nuclear and membrane-associated tumor suppressor that contains several conserved features: a semialdehyde dehydrogenase domain, a N-terminal beta-alpha-beta fold that may bind NADP(H), and a 20-amino acid N-terminal alpha helix that may enable protein docking. Proapoptotic TIP30 activity resides in the N-terminal domain. A 133-amino acid membrane-associated variant TC3 Protein contains a unique short C-terminus that confers antiapoptotic properties. TIP30 appears to be a RNA polymerase II transcription co-activator and may function as a co-activator for HIV-1 TAT protein. TIP30 may suppress metastasis. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                   
[25550] "Encoded by human IFITM1 Gene (IFN-Induced Transmembrane Protein Family), 125-amino acid 14-kD Interferon-Induced Transmembrane Protein 1 is an IFN-alpha- and -gamma-inducible membrane protein subunit of a multimeric complex involved in antiproliferative and homotypic adhesion signal transduction. IFITM1 Protein appears to demarcate germ cells from somatic neighbors and to mark the onset of germ cell competence. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25551] "Encoded by human IFNA13 Gene (IFN Alpha Family) and expressed by macrophages, secreted 189-amino acid 21.7 kD (precursor) Interferon Alpha 13 contains the interferon alpha/beta domain and appears to regulate antiviral defense, cell growth, and immune activation; it stimulates the production of a protein kinase and an oligoadenylate synthetase. Interferons Alpha-13 and Alpha-1 have identical protein sequence. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25552] "Encoded by human INFA2 Gene (IFN Alpha Family) and expressed by macrophages, secreted 188-amino acid 21.6 kD (precursor) Interferon Alpha 2 contains the interferon alpha/beta domain, exhibits interferon-alpha/beta receptor ligand activity, and appears to regulate antiviral defense, cell growth, and immune activation. It stimulates the production of a protein kinase and an oligoadenylate synthetase. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25553] "Encoded by human IFNW1 Gene (IFN Alpha, Beta, Delta Family), secreted 195-amino acid 22 kD (precursor) Interferon Omega 1, a type I interferon protein containing the interferon alpha/beta domain, appears to regulate antiviral defense, cell growth, and immune activation. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25554] "The Caribbean or the West Indies is a group of islands in the Caribbean Sea. These islands curve southward from the bottom tip of Florida to the Northwest of Venezuela in South America. They are at least 7 000 islands, islets, reefs and cayes in the region. There exist twenty-five territories, including sovereign states, overseas departments and dependencies. (from Wikipedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25555] "Leukemia Inhibitory Factor (LIF), encoded by the LIF gene, is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action is mediated through a high-affinity receptor complex composed of Leukemia Inhibitory Factor Receptor (a low-affinity LIF binding chain) and gp130 (a high-affinity converter subunit). The high-affinity complex also binds oncostatin M, a related cytokine. Both Leukemia Inhibitory Factor Receptor and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. (from OMIM)"                                                                                                                                                                                    
[25556] "Growth Differentiation Factor 5, encoded by the human GDF5 gene, is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein is predominantly expressed in long bones during human embryonic development. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. (From LocusLink, Swiss-Prot and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25557] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25558] "Disorders of the blood, some of which lead to leukemia."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25559] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25560] "Lysyl oxidase; a copper-dependent enzyme that initiates the crosslinking of collagens and elastin, oxidizes lysine residues to alpha-aminoadipic-delta-semialdehyde. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25561] "Growth Differentiation Factor 8, encoded by the human GDF8 gene, is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein plays a role in the control and maintenance of skeletal muscle mass. It acts specifically as a negative regulator of skeletal muscle growth by signaling through receptor serine/threonine kinases. This protein is synthesized as a preprotein activated by 2 proteolytic cleavages. Removal of the signal sequence is followed by cleavage at a tetrabasic processing site, resulting in a 26-kD amino-terminal propeptide and a 12.5-kD carboxy-terminal peptide, a dimer of which is the biologically active portion of the protein. (From LocusLink, OMIM and NCI)"                                                                                                                                                                                                                                                     
[25562] "Leukotriene B4 Receptor, encoded by the LTB4R gene, belongs to family 1 of G-protein coupled receptors. This protein is a receptor for extracellular ATP, UTP and ADP, and its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. This protein may be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. It is also a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immumne response. It is expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver, with high level of expression in lymphoid tissues. (from Swiss-Prot)"                                                                                                                                                                                                                                                           
[25563] "A country in Western Africa, bordering the Gulf of Guinea, between Cote d'Ivoire and Togo. (CIA World Factbook 2002)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25564] "Latent TGF Beta Binding Protein 2, encoded by the LTBP2 gene, is a latent transforming growth factor-beta (TGF-beta) binding protein. Binding of this protein to TGF-beta in the extracellular-matrix serves as an important mechanism to regulate TGF-beta function. Mutations in LTBP2 have been identified in two instances of atypical Marfan syndrome. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25565] "Leukocyte Tyrosine Kinase is encoded by the human LTK gene. A set of cDNAs represents differently spliced human LTK mRNAs. These cDNAs predict a truncated receptor protein lacking the tyrosine kinase domain and a soluble receptor protein that has neither a transmembrane nor a tyrosine kinase domain. The LTK gene produces not only the putative receptor tyrosine kinase for unknown ligand but also multiple protein products that may have different functions. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25566] "LY6E gene encodes a cell surface protein containing 20 N-terminal amino acids corresponding to a signal peptide and an extracellular sequence of 111 amino acids. LY6E protein shares some homology with CD59 and some growth factor receptors; highest homology is with the murine LY6 multigene family of small cysteine-rich proteins differentially expressed in several hematopoietic cell lines and with apparent signal transduction function. RIGE is the closest human LY6 family homolog. RIGE expression is not restricted to myeloid differentiation; it is also present in thymocytes and other tissues at different levels. By Northern blot analysis, the highest expression of RIGE was found in liver, kidney, and ovary in addition to peripheral blood leukocytes. (OMIM)"                                                                                                                                                                                                       
[25567] "Encoded by human KOC1 Gene, IGF-II mRNA-Binding Protein 3 contains a KH domain and binds to the 5-prime UTR of the IGF-II leader 3-prime mRNA. It may repress translation of IGF-II during late development. (from LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25568] "Similar to RAS kinase suppressor (Drosophila) and encoded by human KSR Gene (SER/THR PK Family), Kinase Suppressor of RAS-1 is a positive modulator of RAS-MAP kinase signaling. KSR Homologs are found in C. elegans and mouse. The predicted 873-amino acid mouse protein contains a kinase domain similar to RAF kinases; human protein is nearly 95% similar to mouse. In unstimulated cells, CTAK1 constitutively associates with KSR1, phosphorylating Ser392 and conferring cytoplasmic sequestration by 14-3-3 binding. In response to growth factor, KSR1 Ser392 phosphorylation falls, allowing KSR1 to localize with activated RAS and RAF1 at the plasma membrane and facilitating phosphorylation required for activation of MEK and MAPK. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                
[25569] "Countries of southwest Asia and northeastern Africa.  The CIA Factbook considers this region to include those countries east of Egypt and south of Turkey and extending to Iran in the east."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25570] "Widely expressed (abundant in heart, brain, and skeletal muscle), human PTPN11 Gene (Non-Receptor PTP Family) encodes 593-aa 68-kDa cytoplasmic Non-Receptor Type 11 Protein Tyrosine Phosphatase, containing a catalytic domain and 2 tandem phosphotyrosine binding SH2 domains that mediate substrate interactions (MPZL1, PTPNS1) and may modulate phosphatase activity. PTPN11 appears to regulate signaling events involved in mitogenesis, metabolic control, transcription, migration, adhesion, cell morphogenesis, and blood cell development. Activated by IL-6, PTPN11 regulates RAFT Kinase and may regulate apoptosis. PDGF-induced C-terminal tyrosine phosphorylation creates a binding site for the GRB2 SH2 domain. PTPN11 also appears to be involved in EGFR signaling and to potentiate the MAP kinase pathway. PTPN11 defects cause LEOPARD syndrome, Noonan syndrome, and JMML. (NCI)"                                                                                       
[25571] "Preferentially expressed in lymphoid tissues (highest in thymus) and encoded by human LAF4 Gene (LAF4/MLLT2 Family), 1227-amino acid 134-kD nuclear DNA-binding transcriptional activator Lymphoid Nuclear Protein 4 may function in lymphoid development and oncogenesis. Greatest similarity to MLLT2 occurs in the N-terminal and C-terminal regions. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25572] "Encoded by human PTPN1 Gene (Non-Receptor PTP Family), 435-aa 50-kDa Non-Receptor Type 1 Protein Tyrosine Phosphatase is a negative regulator of insulin signaling by dephosphorylating insulin receptor kinase and is associated with the endoplasmic reticulum via its C-terminal domain and its phosphatase domain oriented towards the cytoplasm. PTPN1 may also dephosphorylate EGFR kinase, as well as JAK2 and TYK2 kinases, suggesting a role in cell growth control, and cell response to interferon stimulation. Protein Tyrosine Phosphatases typically regulate cellular processes such as cell growth, differentiation, and mitotic cycle. Oxidation of Cys-215 forms a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity; the active site is restored by reduction. (NCI)"                                                                                                                               
[25573] "Expressed in appendix, thymus, lymph node, lung, and spleen and encoded by human LAMP3 Gene (LAMP Family), Lysosomal-Associated Membrane Protein 3 is likely involved in antigen processing by lymphoid dendritic cells that capture antigens, differentiate, and induce T-cell responses. Expression increases in mature interdigitating dendritic cells in T-cell areas. A 416-amino acid 70- to 90-kD type I integral membrane protein (larger than predicted, 44-kD), DCLAMP contains N-and O-glycosylation sites, a LAMP domain, a large extracellular domain, a transmembrane domain, and a 10-amino acid cytoplasmic domain containing a conserved GY lysosomal targeting motif. Expression is up regulated in carcinomas of esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid, and parotid tissues. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                   
[25574] "Encoded by human PTPN12 Gene (Non-Receptor PTP Family), 780-aa 88-kDa cytoplasmic Non-Receptor Type 12 Protein Tyrosine Phosphatase contains a C-terminal PEST motif protein-protein interaction domain. PTPN12 binds to and dephosphorylate the c-ABL product. It also interacts with, and dephosphorylates, cytoskeletal and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and Paxillin, suggesting a role in controlling cell shape and mobility. PTPs typically regulate cell growth, differentiation, and mitotic cycle. Defects in PTPN12 are found in some colon cancers. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                      
[25575] "Predominantly expressed in lymphoid tissues as distinct alternative isoforms by human PTPN22 Gene (Non-Receptor PTP Family), Non-Receptor Type 22 Protein Tyrosine Phosphatase associates with and appears to regulate adapter protein CBL function and its associated protein kinases in the T-cell receptor signaling pathway. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25576] "Expressed predominantly in hematopoietic cells by human PTPN6 Gene (Non-Receptor PTP Family), 3 distinct alternative isoforms of cytoplasmic serine/tyrosine phosphorylated Non-Receptor Type 6 Protein Tyrosine Phosphatase contain two tandem N-terminal phosphotyrosine binding SH2 domains that mediate interaction with substrates and may modulate phosphatase activity through interaction with other cellular components. A key regulator of hematopoiesis, PTPN6 interacts with, and dephosphorylates, many phosphoproteins involved in hematopoietic cell signaling pathways. PTPN6 binds to PTPNS1, LILRB1, and LILRB2. Protein Tyrosine Phosphatases typically regulate cell growth, differentiation, and mitotic cycle. (NCI)"                                                                                                                                                                                                                                                         
[25577] "Widely expressed in fetal and adult tissues and encoded by human LATS1 Gene (SER/THR PK Family), conserved putative tumor suppressor Large Tumor Suppressor Homolog 1 is an 1130-amino acid 127-kD Ser/Thr protein kinase cell cycle regulator containing a catalytic domain and an UBA/TS-N domain. The C-terminal kinase domain of human and mouse proteins share 99% identity; human and Drosophila share 74% identity. The kinase domain and N-terminal region interact, suggesting intramolecular regulation. Phosphorylated in a cell cycle-dependent manner (late prophase-metaphase), LATS1 is a negative regulator of CDC2/cyclin A. In early mitosis, it complexes (via the N-terminal region) with the mitotic apparatus cell cycle controller CDC2 kinase; the complex shows reduced H1 histone kinase activity. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                           
[25578] "Preferentially expressed as 2 distinct alternative isoforms in thymic and spleen hematopoietic cells by human early response PTPN7 Gene (Non-Receptor PTP Family) in lymphokine-stimulated cells, cytoplasmic Non-Receptor Type 7 Protein Tyrosine Phosphatase is likely involved in regulation of TCR signaling through dephosphorylating MAP kinase pathway molecules; the noncatalytic N-terminus interacts with and suppresses MAP kinase activities. PTPN7 appears to regulate T and B lymphocyte development and signal transduction. Protein Tyrosine Phosphatases typically regulate cellular processes including cell growth, differentiation, and mitotic cycle. (NCI)"                                                                                                                                                                                                                                                                                                                   
[25579] "Expressed in many tissues (highest in heart and skeletal muscle) and encoded by human LATS2 Gene (SER/THR PK Family), the 125-kD nuclear Ser/Thr protein kinase Large Tumor Suppressor Homolog 2 contains seven PAPA repeats (dipeptide proline-alanines likely involved in protein-protein interactions) and a C-terminal kinase domain. Human and mouse proteins are most closely related to LATS1 proteins, followed by Drosophila Lats. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25580] "Encoded by human LCP2 Gene and expressed in peripheral leukocytes, spleen, thymus, T-cells, B-cells, and monocytes, modular 533-amino acid 76-kD adaptor/scaffold Lymphocyte Cytosolic Protein 2 contains three domains; a PEST domain and phosphorylatable tyrosine residues in the acidic N-terminus, a GRB2 binding site in the central proline-rich domain, and a C-terminal SH2 domain. SLP-76 associates constitutively or inducibly with GRB2 and FYB adapter proteins and with ZAP70 and SYK as a substrate. By supporting receptor-mediated signal transduction, SLP-76 promotes thymic development and T-cell development and activation, as well as mast cell and platelet function. SLP-76 may collect all pre-TCR signals that drive thymocyte development and appears required for separate development of lymphatic vessels from blood vessels. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                         
[25581] "Containing a TGF-beta family domain, similar to LEFTYA, and encoded by human LEFTB Gene (TGF-Beta Family), secreted 366-amino acid 41-kD Left-Right Determination Factor B (preproprotein) undergoes cell-specific alternative processing into three different products. Processing may occur at R-X-X-R sites. LEFTB appears required for left-right determination during early presomite development in mammals. It may serve as a feedback inhibitor to restrict the range of nodal signaling during establishment of the axis. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                     
[25582] "Encoded by human LEPR Gene (gp130 Cytokine Receptor Family), five Leptin Receptor isoforms are variously expressed in liver, hypothalamus, heart, small intestine, hematopoietic tissues, choroid plexus, prostate, ovary, lung, and kidney. Isoform E may be soluble. The 1165-amino acid 132.5-kD (precursor) type I membrane protein contains 3 fibronectin III-like domains and is TYR phosphorylated; the cytoplasmic domain appears essential for signal transduction. LEPR appears involved in regulation of fat metabolism through hypothalamic effects, angiogenesis, lymphopoiesis, and possibly reproduction. LEPR appears to activate JAK kinase and STAT3, -5, and -6. LEPR malfunction is associated with diabetes and obesity. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                          
[25583] "The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. (from LocusLink, OMIM. Swiss-Prot)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25584] "Widely expressed and encoded by human LGALS3BP Gene (MSR1 Superfamily), 585-amino acid extracellular Galectin 3 Binding Protein contains an N-terminal MSR1 Cys-rich domain and binds LGALS3 via carbohydrate-specific interaction. MAC2BP is a potent stimulator of host immune defense systems, such as NK and LAK cell cytotoxicity, and can induce IL2 cytokine production. Oncogenic transformation, viral infection, or pathogen invasion enhance MAC2BP production. LGALS3BP is elevated in the serum of cancer and HIV patients. (from LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                           
[25585] "Constitutively and ubiquitously expressed by human LGALS8 Gene (S-Lectin Family), 316-amino acid 35.5-kD extracellular Galectin 8 contains two carbohydrate-binding (recognition) domains (CRDs) and binds to beta galactoside in cell adhesion, cell cycle regulation, inflammation, immunomodulation, apoptosis, and metastasis. Galectin 8 may be involved in activation of various cell types through cross-linkage of cell surface glycoproteins and may be involved in some types of cancer. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25586] "Predominantly expressed in neural tissues and encoded by human LGI1 Gene, a 557-amino acid 64-kD precursor yields mature 60-kD putative tumor suppressor Leucine-Rich Glioma-Inactivated Protein, containing a putative extracellular N-terminus and hydrophobic transmembrane segment, as well as leucine-rich repeats (LRR) with conserved cysteine-rich flanking sequences. LGI1 shows high similarity in the LRR domain with transmembrane and extracellular receptors and adhesion proteins. Translocation rearrangements of LGI1 reduce or abrogate expression in several glioblastomas and brain tumors. LGI1 mutations appear responsible for autosomal dominant partial epilepsy with auditory features. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                      
[25587] "Encoded by conserved human LHX1 Gene (LIM/Homeobox Family) and expressed in brain, thymus, and tonsil, 384-404-amino acid 44.5-kD nuclear LIM Homeobox Protein 1 is a putative transcriptional regulatory protein containing two CYS-rich zinc ion-binding LIM domains and a DNA-binding homeobox domain. LIM1 may regulate the head organizer and control differentiation and development of neural and lymphoid cells. LIM1 and LMX1B appear to control lateral column motor axon dorsal/ventral trajectory in the developing limb. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                  
[25588] "Related to 'apterous' (Drosophila) and encoded by human LHX2 Gene (LIM/Homeobox Family), 406-amino acid 44-kD nuclear LIM Homeobox Protein 2 is a putative transcription factor containing two CYS-rich zinc ion-binding LIM domains and a DNA-binding homeobox domain. LIM2 may control differentiation and development of neural and lymphoid cells. Rodent LH2 is expressed in the central nervous system and in immature B- and T-cells. In the pituitary, mouse Lh2 regulates expression of the pituitary glycoprotein hormone alpha subunit. High expression is observed in chronic myelogenous leukemia (CML). (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                  
[25589] "Encoded by human HPCA Gene (Recoverin Subfamily), 192-amino acid 22-kD neuron-specific Hippocalcin is myristoylated, plasma membrane-associated, binds two Ca(2+) ions, and contains the EF-hand Ca(2+)-binding motif. Human amino acid sequence shows complete identity (and 92% nucleotide identity) with rat; it is also identical to mouse hippocalcin. Hippocalcin shows striking similarity to photoreceptor Ca(2+)-sensitive proteins that regulate photosignal transduction. Displaying recoverin activity and a Ca(2+)-dependent inhibition of rhodopsin kinase, it may be involved in the Ca(2+)-dependent regulation of rhodopsin phosphorylation. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                          
[25590] "Encoded by human DDX26 Gene (DEAD Family), the highly conserved candidate tumor suppressor 1687-amino acid 188.5-kD DEAD/H Box Protein 26 contains a vWF type A domain. With a likely important cellular function, DDX26 is expressed in a variety of fetal and adult tissues. DEAD box proteins, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                            
[25591] "An orderly arrangement. (from the American Heritage Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25592] "An individual portion of food or drink."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25593] "MAP kinase gene products act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25594] "Encoded by MAPK11 Gene, MAP Kinase 11 is a member of the MAP kinase family, integration points for multiple biochemical signals and involved in a variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK11 is most closely related to p38 MAP kinase; both can be activated by proinflammatory cytokines and environment stress. MAPK11 is activated through phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of MAPK11. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                     
[25595] "The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. (LocusLink)"                                      
[25596] "Encoded by MAPK12 Gene (MAPK Family), MAP Kinase 12 constitutes a member of the stress-activated protein kinases involved in transduction of extracellular signals. SAPK3 functions as a signal transducer during differentiation of myoblasts to myotubes. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25597] "Encoded by MAPK13 Gene (MAPK Family), MAP Kinase 13 is closely related to p38 MAP kinase; both can be activated by proinflammatory cytokines and cellular stress. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAP kinase kinases 3 and 6 can phosphorylate and activate MAPK13. Transcription factor ATF2, and microtubule dynamics regulator Stathmin have been shown to be the substrates of this kinase. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                         
[25598] "Expressed in brain, heart, placenta, pancreas, skeletal muscle, lung, liver, and kidney, by human MAPK14 Gene (MAPK Family), the four isoforms (varying by internal segments and C-termini) of (Ser/Thr) Mitogen-Activated Protein Kinase 14 are involved in oxidative/hypoxic/environmental/genotoxic stress, transcription, cell cycle regulation, and apoptosis. Bound to cytoplasmic PTPRR and activated by cell stress, proinflammatory cytokines, LPS, Thr/Tyr phosphorylation by MAP2K3, MAP2K6, and MAP2K4, and autophosphorylation by MAP3K7IP1/TAB1 interaction, p38 MAPK phosphorylates MAPKAPK2, MAPKAPK5, ELK-1, ATF2, MEF2C, MAX, CDC25B, and p53. p38 is inhibited by DUSP1 and CSAID drugs. (NCI)"                                                                                                                                                                                                                                                                                  
[25599] "Highly expressed in heart and brain by human MAPK4 Gene (MAPK Family), 557-aa 63-kDa MAP Kinase 4 is a Ser/Thr protein kinase activated by tyrosine kinase growth factor receptors that translocates to the nucleus to phosphorylate nuclear targets and likely promote entry in the cell cycle. MAPK4 also phosphorylates MAP2. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25600] "Expressed in skeletal muscle, brain, heart, placenta, lung, liver, pancreas, kidney, and fibroblasts by human MAPK6 Gene (MAPK Family), 721-aa 83-kDa nuclear MAP Kinase 6 is a Ser/Thr protein kinase activated by protein phosphorylation cascades that acts as an integration point for multiple biochemical signals and likely promotes entry in the cell cycle. MAPK6 phosphorylates MAP2. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25601] "Induced by hypoxia, growth factors, and cytokines, widely expressed human HIF1A Gene encodes 2 alternative isoforms of cytoplasmic S-nitrosylated 826-aa 93-kDa (phosphorylated) DNA-binding (HRE) bHLH Hypoxia-Inducible Factor 1 Alpha Subunit (HIF1 TF) involved in hypoxic responses and angiogenesis. HIF1 beta is ARNT. HIF1A contains 2 PAS dimerization domains, a PAC domain, and the transactivation domains (NTAD/CTAD) are repressed by an inhibitory domain. HIF1A requires CREBPB/EP300 (via TAZ-1 domains) and is enhanced by NCOA1/NCOA2. APEX activates CTAD and potentiates NCOA1/CREBBP activation. Normoxic Pro-hydroxylation (ODD domain by EGLN1/EGLN2), promoting VHL interaction and ubiquitin degradation, is hypoxically impaired, resulting in stabilization. ARD1 acetylation increases VHL interaction and degradation. Normoxic Asn-hydroxylation by HIF1AN abrogates CREBBP and EP300 interaction preventing transcription. (NCI)"                                   
[25602] "The gene product of ARNT is the beta subunit of hypoxia-inducible factor 1, which function as transcription factor.  It also functions as aryl hydrocarbon receptor nuclear translocator upon ligand binding, thus the name ARNT.  ARNT gene contains 22 exons, varying in size from 25 to 214 bp, and spans 65 kb. Splice junctions follow the GT/AG consensus except for intron 11 starting with GC at its 5-prime end. (From LocusLink, OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25603] "The ARNT2 gene encodes Aryl Hydrocarbon Receptor Nuclear Translocator 2, a member of a novel transcription factor family consisting of a conserved basic helix-loop-helix (bHLH) structural motif contiguous with a PAS domain. (From LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25604] "Growth Differentiation Factor 9, encoded by the human GDF9 gene, is a member of the TGF-beta superfamily. This protein interacts with bone morphogenetic protein-15 and Bone morphogenetic protein receptor type II is a receptor for Growth Differentiation Factor-9. Both GDF9 mRNA and protein are abundantly expressed in oocytes of primary follicles in human ovary, suggesting that the GDF9 transcript is translated at this early stage of folliculogenesis. GDF9 is crucial for normal ovarian folliculogenesis and female fertility. GDF9 regulates human folliculogenesis in a manner specific to the ovary. A dysregulation of GDF9 expression may contribute to aberrant folliculogenesis in PCOS and PCO women. (From OMIM, Swiss-Prot and NCI)"                                                                                                                                                                                                                                     
[25605] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25607] "Highly expressed as four alternative transcripts in heart, placenta, lung, kidney, and skeletal muscle by human MAPK7 Gene (MAPK Family), 815-aa 88.6-kDa MAP Kinase 7 is a Ser/Thr kinase specifically activated by MAP2K5 (not MEK1/MEK2) and involved as an integration point for multiple downstream signals of various receptors, including receptor type kinases and GPCRs, in cell proliferation, differentiation, transcription regulation, and development. Autophosphorylated and likely activated by tyrosine and threonine phosphorylation by upstream kinase, MAPK7 translocates to the nucleus in response to extracelluar signals and regulates gene expression by phosphorylating and activating target transcription factors. The C-terminus may have an autoregulatory role, and the second Pro-rich region may interact with actin, targeting MAPK7 to specific cell locations. (NCI)"                                                                                           
[25608] "Expressed as alpha-1, -2, beta-1, -2 isoforms by human MAPK9 Gene (MAPK Family), MAP Kinase 9 is a stress/cytokine-induced Ser/Thr kinase that acts as an integration point for multiple biochemical signals involved in target transcription factor regulation, such as c-Jun and ATF2. Alpha-1, and 2 bind c-Jun; beta-1 and 2 bind ATF2. JunB and JunD are not substrates for alpha-2. Inhibited by dual specificity phosphatases, and phosphothreonine/tyrosine activated by a Ras-dependent dual specificity MAP2K4/MAP2K7 cascade, MAPK9 mediates immediate-early gene expression. MAPK9 binds scaffolding proteins MAPK8IP1/2/3. MAPK9/UV-induced apoptosis appears related to cytochrome c-mediated cell death. Increased p53 stability in nonstressed cells results from MAPK9 blocked p53 ubiquitination. MAPK9 appears required for T-helper cell differentiation into Th1 cells. (NCI)"                                                                                                 
[25609] "Encoded by human MAPRE1 Gene (MAPRE/RP/EB Family), 268-aa 30-kDa Microtubule-Associated Protein RP/EB Family Member 1 contains a CH domain and a C-terminal domain that binds to APC. In interphase, MAPRE1 localizes to microtubules (growing ends); during mitosis, MAPRE1 is associated with centrosomes and spindle microtubules. MAPRE1 also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. MAPRE1 also interacts with TERF1. MAPRE1 is likely involved in regulation of microtubule structures, microtubule polymerization, spindle function, and chromosome stability. (NCI)"                                                                                                                                                                                                                                                                                                                                                          
[25610] "NEGF2 is a member of a highly conserved, developmentally regulated human gene family. The gene product exhibits neurite outgrowth-promoting activity and may play a role in nervous system development and/or maintenance. Expression of NEGF2 is predominant only for a short period from approximately one-half to two-thirds of the way through gestation; before and after that, it is barely detectable. The gene codes for a 143-residue protein which is a precursor for a mature protein of 121 amino acids and is 46% homologous with another heparin-binding neurite outgrowth-promoting factor, NEGF1. NEGF2 is also known as midkine. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines.(from OMIM)"                                                                                                                                                            
[25611] "Expressed in immunohepatopoietic tissues and in brain by human MEIS1 Gene (TALE/MEIS Family), 390-aa 43-kDa Homeobox Protein MEIS1 contains one homeobox domain, the only conserved motif in the entire protein. Homeobox genes play a crucial role in normal development. Mouse Meis1 regulates Pbx1 protein activity by promoting nuclear import and specifies cell fates and differentiation patterns along the proximodistal limb axis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25612] "Expressed in monocytes, bone marrow, and tissues of epithelial and reproductive origin by human MERTK Gene (AXL/UFO Family), 999-aa 110-kDa (precursor) Receptor Tyrosine Kinase MERTK contains 2 extracellular N-terminal Ig-like C2-type domains and 2 membrane proximal fibronectin type III domains, a putative transmembrane segment, a tyrosine kinase KWIAIES domain, several N-glycosylation sites, and tyrosine phosphorylation sites. Not expressed in normal B- and T-lymphocytes, MERTK is expressed in numerous neoplastic B-and T-cell lines. MERTK defects cause retinitis pigmentosa. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                        
[25613] "Growth Factor Independence-1B, encoded by the human GFI1B gene, is a zinc finger protein. This protein is a transcription factor with specific involvement in the regulation of erythroid cell growth in normal erythropoiesis through modulating erythroid-specific gene expression. The function of GFI1B to modulate transcription depends on promoter context. Human GFI1B expression by Northern blot analysis is highest in bone marrow and fetal liver as well as in the chronic myeloid leukemia cell line K562 with lower levels in other hematopoietic precursor cells. Expression of GFI1B is highly restricted to hematopoietic stem cells, erythroblasts, and megakaryocytes. Its expression does not promote erythroid commitment, but enhances proliferation of immature erythroblasts. The chromosomal region of this gene is translocated to chromosome 22q11 in chronic myeloid leukemia. (From OMIM, PubMed 12351384 and NCI)"                                                   
[25614] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25615] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25616] "A pain management technique based on improvement of functional ability, strengthening, and maintenance of range of motion.  It is believed that endorphin release during exercise minimizes pain and improves effectiveness of analgesics."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25617] "Expressed in mammary epithelia and activated macrophages by human MFGE8 Gene, 387-aa 43-kDa (precursor) Milk Fat Globule-EGF Factor 8 Protein is a multidomain cell surface (and secreted) protein that contains an EGF-like domain, C-terminal F5/8 type C domains, and the cell adhesion tripeptide RGD. MFGE8 recognizes aminophospholipids (phosphatidylserine) and binds to cells via its RGD motif; MFGE8 binds strongly to cells expressing alpha-V-beta-3 integrin. Expressed by activated macrophages, MFGE8 specifically binds to apoptotic cells and appears to promote macrophage phagocytosis of apoptotic cells. MFGE8 is overexpressed in several carcinomas. (NCI)"                                                                                                                                                                                                                                                                                                                 
[25618] "GDNF Family Receptor Alpha 2, encoded by the human GFRA2 gene, is a member of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) Receptor family. GDNF and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 is required for the development of the myenteric nerve plexus. This protein is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This receptor acts preferentially as a receptor for NTN compared to its other family member, GDNF Family Receptor Alpha 1. Two alternatively spliced transcript variants, long and short, have been described for this gene but their full length nature is not known. The short form is found in brain and placenta. This gene is a candidate gene for RET-associated diseases. (From LocusLink, OMIM, Swiss-Prot and NCI)"          
[25619] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25620] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25621] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25622] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25623] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25624] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25625] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25626] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25627] "Excision of in-frame internal protein sequences (inteins) of a precursor protein, coupled with ligation of the flanking sequences (exteins). Protein splicing is an autocatalytic reaction and results in the production of two proteins from a single primary translation product: the intein and the mature protein. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25628] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25629] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25630] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25631] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25632] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25633] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25634] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25635] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25636] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25637] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25638] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25639] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25640] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25641] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25642] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25643] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25644] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25645] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25646] "This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase.  Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. (from LocusLink)"                                                                                                                                                   
[25647] "This region represents the germline organization of the T cell receptor alpha locus. The alpha locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the alpha chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                 
[25648] "This region represents the germline organization of the T cell receptordelta locus. The delta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. (from LocusLink)"                                                                                                                                                                                                                                                                 
[25649] "This region represents the germline organization of the T cell receptor gamma locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                 
[25650] "This region represents the germline organization of the immunoglobulin heavy chain locus. The locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)"                                                                                                                                                                                                  
[25651] "This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)"                                                                                                                                                                                                                                                                    
[25652] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25653] "This region represents the germline organization of the kappa light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)"                                                                                                                                                                                                                                                                     
[25654] "One component of the alpha-beta T-cell receptor. Encoded by a locus on chromosome 14. Somatic recombination results in formation of the active gene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25655] "One component of the alpha-beta T-cell receptor. Encoded by a locus on chromosome 7. Somatic recombination results in formation of the active gene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25656] "One component of the gamma-delta T-cell receptor. Encoded by a locus on chromosome 7. Somatic recombination results in formation of the active gene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25657] "One component of the gamma-delta T-cell receptor. Encoded by a locus on chromosome 14. Somatic recombination results in formation of the active gene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25658] "Glucocorticoid-inducible 6-exon 3.7-kb human NFKBIA Gene (NFKBI Family) encodes 317-aa 36-kDa cytoplasmic I-Kappa-B-Alpha, containing 5 ANK repeats that interact with p65 RELA C-terminal REL homology regions. By complexing with and trapping NF-Kappa-B in the cytoplasm, unphosphorylated NFKBIA inhibits NFKB target gene transcription in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. NFKBIA tyrosine phosphorylation leads to dissociation from NFKB, disabling inhibition of NFKB DNA-binding. Stimulus-dependent IKBKA/IKBKB serine phosphorylation of NFKBIA results in polyubiquitination and rapid degradation via the ubiquitin system. (NCI)"                                                                                                                                                                                                                                                                                       
[25659] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25660] "Glioma Tumor Suppressor Candidate Region Gene 1 Protein is encoded by the human GLTSCR1 gene. This protein is expressed at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver, and kidney. Mutation analysis of the transcripts in the gene region in diffuse gliomas with 19q deletions revealed no tumor-specific mutations. However, a marker in GLTSCR1, presumably separated from RAI by several million bases, supplements the most significant marker in RAI in separating cases of basal cell carcinoma (BCC) from controls, which may suggest the presence of an independent, risk-modulating variation in this second gene region. (From OMIM, Swiss-Prot, PubMed 12117772 and NCI)"                                                                                                                                                                                                                                            
[25661] "Expressed in heart, pancreas, placenta, liver, skeletal muscle, kidney, brain, and lung by human GLTSCR2 Gene (GLTSCR2 Family), 478-aa 54-kDa nuclear Glioma Tumor Suppressor Candidate Region Gene 2 Protein interacts with HSV-1 early proteins ICP22 and ICP0. GLTSCR2 function is unknown. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25662] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25663] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25664] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25665] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25666] "The conscious tendency to act, usually an aspect of mental process."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25667] "A monoclonal antibody with potential antineoplastic activity.  MDX-060 is a fully human antibody that targets CD30, a member of the tumor necrosis factor receptor superfamily and a molecule found on activated lymphocytes.  CD30 is over-expressed in various lymphoproliferative disorders, Hodgkin's disease and other lymphomas, and other cancers. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25668] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25669] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25670] "A recombinant agent consisting of a genetically-modified adenovirus 5 vector encoding the protein cytokine tumor necrosis factor (TNF) alpha.  TNF exhibits potent cytolytic properties that can destroy tumor cells; the adenovirus 5 vector efficiently infects tumor cells, delivering tumor-specific TNF. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25671] "An autologous vaccine composed of dendritic cells (DC) that have been transduced with a p53 tumor suppressor gene-modified virus. When the autologous dendritic cell-adenovirus p53 vaccine is administered, the host cytotoxic T lymphocytes (CTL) are directed against p53-positive tumor cells, which may result in tumor cell death and decreased tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25672] "A cancer vaccine consisting of lymphocytes harvested from a patient with lung cancer and induced to become antigen-presenting cells (APCs) known as dendritic cells.  The dendritic cells are transduced with the gene encoding an antigen specific to the patient's cancer and then returned to the patient.  In the host, the altered cells stimulate the immune system to mount a primary T cell response against lung tumor cells expressing the target antigen.  Dendritic cell-autologous lung tumor vaccines have been investigated for use in cancer immunotherapy. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                
[25673] "IDEC-114 is a monoclonal antibody that targets CD80, an immune costimulatory molecule.  The antibody inhibits the binding of the CD80 ligand on antigen-presenting cells to the CD28 receptor on T cells, thus blocking the second signal for inflammatory T-cell activation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25674] "IDEC-152 was developed to decrease the body's response to allergens, thereby affecting diseases related to asthma and allergic disorders. This monoclonal antibody binds to the CD23 receptor, by which IDEC-152 may favorably influence asthma through its selective regulation of IgE production and its inhibition of other inflammatory pathways.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25675] "A murine immunoglobulin G1 (IgG1) monoclonal anti-idiotype antibody (ACA125).  Vaccination with monoclonal antibody ACA125 anti-idiotype vaccine stimulates the host immune system to mount an antibody response and subsequent antibody-dependent cell-mediated cytotoxicity response against CA125 positive tumor cells, thereby decreasing tumor growth. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25676] "A class of vaccines that consist of anti-idiotype monoclonal antibodies against the tumor-associated antigen disialoganglioside GD2 with potential antineoplastic activity.  Vaccination with a monoclonal antibody GD2 anti-idiotype vaccine produces an immunoglobulin response against GD2 with subsequent destruction of GD2 positive tumor cells via antibody-dependent cellular cytotoxicity (ADCC).  GD2 is overexpressed in melanoma, neuroblastoma, soft tissue sarcoma, and small cell carcinoma of the lung. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25677] "A subgroup of antineoplastic antibiotics Quinone derivatives of anthracene that exhibit cytotoxic activity through the intercalation of DNA and inhibition of topoisomerase II, a key enzyme involved in DNA synthesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25678] "Comedo; having a black or dark core or plug."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25679] "Nerve cells that employ dopamine as their neurotransmitter."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25680] "Luminal; relating to the lumen of a blood vessel or other tubular structure. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25681] "Mixed; being composed of a combination of normal and tumor cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25682] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25683] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25684] "Pigmented animal hemisphere of the amphibian blastula."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25685] "Site of initiation of gastrulation in the amphibian embryo. The dorsal lip, which forms at the site of the gray crescent, forms the dorsal margin of the blastopore."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25686] "Endoderm and mesoderm are initially specified as a bipotential anlage called the endomesoderm. This bipotential layer is subsequently segregated into endoderm and mesoderm."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25687] "Area consisting of a small depression in the retina containing only cones and where vision is most acute."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25688] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25689] "Yellow endocrine tissue that forms in a ruptured Graafian follicle following the release of an ovum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25690] "The middle one of the three pairs of embryonic renal organs developed in most vertebrates; its duct system is retained in the male as the epididymis and ductus deferens."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25691] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25692] "A duct in the embryo draining the mesonephric tubules."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25693] "The upper jawbone in vertebrates: it is fused to the cranium."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25694] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25695] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25696] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25697] "Stratifin was first identified as an epithelial cell antigen (HME-1) exclusively expressed in epithelia.  The protein is a putative cytoplasmic, p53-regulated homodimeric inhibitor of G2/M progression that is over expressed in squamous cell carcinoma of the head and neck.  The gene is a member of a large 14-3-3 gene family."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25698] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25699] "Cell culture studies demonstrate that TACC2 interacts with GAS41 and the SWI/SNF chromatin remodeling complex. This suggests that defects in TACC2 expression may affect gene regulation, thus contributing to the pathogenesis of some tumors. (from Genomics 2003;81:192-201)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25700] "Encoded by human KLRB1 Gene (C-Type Lectin Superfamily, NKRP1 Family) and preferentially expressed by natural killer lymphocytes and some peripheral T-cells, the type II membrane NKRP1A Protein (external C-terminus) contains a 158-amino acid extracellular domain with C-type lectin motifs, a 29-amino acid transmembrane domain, and a 38-amino acid cytoplasmic domain. C-type lectins, including NKRP1 glycoproteins, may regulate NK cell function. NKRP1A protein is 46% identical to rat and mouse NKRP1, and 26% identical to human NKG2A. (from LocusLink, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                            
[25701] "Preferentially expressed in NK lymphocytes, CD94 Antigen (179-amino acid, 20.5-kD CD94-A and 148-amino acid CD94 ALT) is encoded by KLRD1 Gene (C-Lectin Family) and may regulate NK cell function. A type II membrane protein (external C-terminus), CD94 contains a 147-amino acid extracellular domain with C-type lectin motifs, a 26-amino acid transmembrane domain, and a 7-amino acid cytoplasmic domain (absent in CD94 ALT). CD94 forms disulfide-bonded heterodimers with NKG2A, NKG2C, and NKG2E. Nonclassical MHC HLA-E protein ligand binds to CD94/NKG2A, CD94/NKG2B, and CD94/NKG2C NK cell receptors. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                 
[25702] "Encoded by MADD Gene, MADD Protein Isoforms A-G are expressed in adult testis, ovary, brain, heart, and fetal brain and kidney. The 1588-amino acid 176.6-kD isoform D is full-length. Most variants involve 2-4 stretches of 18-43 amino acids in the central region. Isoforms F and G have a different C-terminus. Containing a C-terminal death domain, RGD motif, and a leucine zipper-like motif, SER- and LEU-rich membrane-bound MADD adaptor protein interacts with TNFR1 death domain to propagate apoptotic signaling. MADD can activate ERK2 and JNK1 MAP kinases and induce phosphorylation of Phospholipase A2. MADD appears to link TNFR1 with MAP kinase activation and arachidonic acid release. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                       
[25703] "Encoded by MADH2 Gene (SMAD Family), ubiquitous 438/467-aa 52-kD SMAD2, containing a DWA/MH1 and DWB/MH2 domain, mediates Activin, TGFB, and BMP receptor Ser/Thr kinase cell growth/differentiation regulation. Retained by cytoplasmic SARA, SMAD2/SMAD3 are phosphorylated on conserved C-terminal MH2 docking SER-X-SERs by activated receptor. SMAD2/SMAD3 oligomerize with nuclear SMAD4, disrupting SNON/SMAD4 repressors. SMAD3 causes SNON degradation. SMAD2/SMAD4 activate target promoters. TGFBR activity maintains nuclear SMADs and increases feedback SNON expression. SMAD2 interacts with FAST-1/-2, TGIF, PEBP2-A, CBP, p300, c-SKI, NUP214, NUP153, and SMURF2. MADR2 mutations may disrupt growth inhibition. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                     
[25704] "Encoded by MADH6 Gene (SMAD Family), ubiquitous (predominantly vascular endothelium) SMAD6 Protein Isoforms A (496-aa 53.5-kD) and B (235-aa) act similar to other MAD-proteins as second messengers distal to TGFBRs and contain an N-terminal DWA/MH1 domain and a C-terminal DWB/MH2 domain. An inhibitory SMAD phosphorylated by type 1 receptor kinase, SMAD6 acts as an antagonist of TGF-beta type 1 receptor signaling. A selective inhibitor of BMPs signaling; SMAD6 competes with SMAD4 for receptor-activated SMAD1. SMAD6 interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8, and HOXC9. MADH6 and MADH7 form complexes. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                           
[25705] "Encoded by MADH7 Gene (SMAD Family) and induced by TGF-beta and IFNG, ubiquitous (lung, vascular endothelium highest) 426-amino acid SMAD7 Protein is an inhibitory Activin/TGFBR1 signaling component containing DWA/MH1 and DWB/MH2 domains. SMAD7 lacks C-terminal phosphorylation sites of other MAD proteins, suggesting distinct regulation. Adaptor SMAD7 constitutively recruits nuclear E3 ubiquitin ligase SMURF2 to TGFBR complexes preventing SMAD2 access and causing proteasomal and lysosomal receptor degradation. SMAD7-expressing cells are susceptible to apoptosis induced by TGFB, TNFA, serum withdrawal, or loss of cell adhesion. SMAD7 decreases NFKB activity, promoting apoptosis. RAS suppresses SMAD7 inhibition of NFKB and potentiation of apoptosis. MADH7 and MADH6 form complexes. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                   
[25706] "Encoded by MADHIP Gene, ubiquitous cytoplasmic SARA contains a FYVE domain zinc finger, seen in signaling molecules and required for SARA localization but not SMAD interaction. Able to bind PI-3 phosphate, SARA recruits SMAD2/3 to TGFBR. The SMAD binding domain (SBD) of SARA interacts with the SMAD2/3 MH2 domain; the C-terminal domain interacts with TGFBR. SMAD2/SMAD3 phosphorylation induces SARA dissociation, SMAD2/SMAD4 formation, and SMAD nuclear translocation. Alternate isoforms represent full-length (1425-aa, 156-kD) or truncated protein (1210-aa and 762-aa). Disruption of MADHIP appears to be involved in Alzheimer's disease. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                         
[25707] "Encoded by MAGED1 Gene (MAGE Family), ubiquitous 778-amino acid 86-kD cytoplasmic NRAGE Protein contains a 200-amino acid MAGE homology domain. NRAGE appears to shift from cytoplasm to plasma membrane upon NGF stimulation to interact with p75NTR. NRAGE antagonizes p75NTR association with TRKA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. NRAGE may regulate the function of DLX family members. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25708] "Encoded by MAP2K6 Gene (MAP2K Family), which is activated by UV and osmotic shock, 278-aa MKK6 is expressed in skeletal muscle while 334-aa 37.5-kD MKK6B (longer at the N-terminus) is enriched in heart, skeletal muscle, pancreas, and liver. Tissue-specific splicing may control of MKK6 expression. MKK6 is about 80% identical to MKK3 and 40% identical to MKK4. Probably activated by Ser/Thr phosphorylation, MKK6 Thr/Tyr phosphorylates p38-MAPK exclusively in response to inflammatory cytokines or environmental stress, inducing cell cycle arrest, transcription activation, and apoptosis. Calcium influx triggers the MKK6/p38-MAPK cascade; p38-MAPK activates MEF2s that regulate expression of genes critical for cell survival. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                 
[25709] "Encoded by MAP3K1 Gene (MAP3K Family), MEKK1 Protein is pivotal in the Ser/Thr phosphorylation network that integrates cellular responses to mitogenic and metabolic stimuli. IFNG induces MEKK1 expression. An efficient activator of the JNK cascade, MEKK1 can phosphorylate MEK1/MEK2, which activate MAPKs. The PHD domain of MEKK1, a RING-type zinc finger, exhibits E3 ubiquitin ligase activity toward ERK2. Thus, MEKK1 functions as both an upstream activator of ERK and JNK through its kinase domain and as an E3 ligase through its PHD domain, decreasing ERK1/ERK2 activity. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                          
[25710] "Encoded by MAP3K14 Gene (MAP3K Family) and expressed in small intestine, spleen, thymus, peripheral leukocytes, testis, prostate, ovary, and colon, autophosphorylated 947-amino acid 104-kD cytoplasmic Ser/Thr Protein Kinase NIK is involved in NFKB activation. NIK selectively activates NFKB cascades of TNF/NGF receptors and IL1R type-I. TNFA acts through TRAF2; IL1 acts through IRAK1 and TRAF6. LTBR and CD95 also act through NIK. NIK appears to bind TRAFs 2, 5, and 6, IKKA, and NFKB2/p100. Binding to TRAF2 involves the TRAF2 N- and C-terminal regions. NIK induces NFKB2/p100 processing, degradation of phosphoserine-induced ubiquitinated destruction of IKBA, and release of cytoplasmic NFKB for nuclear translocation and kappa-B DNA-mediated gene expression.  (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                           
[25711] "Encoded by MAP3K7 Gene (MAP3K Family), ubiquitous TAK1 Protein isoforms A, B (606-aa, 67.2-kD), C, and D regulate transcription and apoptosis by mediating TGFB/BMP, IL-1, and stress signaling. Isoforms A, C, and D lack 1-2 coding segments compared to B. C and D frameshifts yield shorter C-termini (may affect TAB2 interaction). Human and mouse TAK1 are 99% identical. The TAK1 N-terminus interacts with TAB1 and contains ATP-binding and kinase domains. With TAB1 and TAB2, TRIKA2-mediated (TRAF6/TRIKA1) ubiquitinated TAK1 phosphorylates IKKB, MAP2K3, MAP2K4, and MAP2K6, which stimulate JNK1 and SAPK2. TAK1 induces NIK-independent IKBA and IKBB degradation and NFKB p50/p65 nuclear translocation. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                            
[25712] "Encoded by MAP3K7IP1 Gene, ubiquitous 504-amino acid 54.6-kD TAK1-Binding Protein 1 is a MAP3K responsible for mediation of TGF-beta receptor signals and activation of TAK1 kinase. The 68 C-terminal amino acids are sufficient for binding and activation of TAK1 kinase activity. The N-terminal 418 amino acids inhibit TGFB-induced gene expression. TAB1 contains a PP2C domain and amino acids 373-418 are required for phosphorylation of p38-alpha. Formation of TRAF6/TAB1/p38-alpha complexes are enhanced by lipopolysaccharide. TAB1 also interacts with BIRC7. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                          
[25713] "Encoded by MAP4K4 Gene (SER/THR Family, STE20 Subfamily), ubiquitous HGK Protein contains a CNH domain and an N-terminal catalytic domain with 11 kinase subdomains; it shares 47-48% amino acid identity with HPK1 and GCK catalytic domains. Of 5 tissue alternative isoforms, variant 2 is longest and contains proline-rich domains. Variants 1 and 3 lack two coding segments and variant 1 contains an extra coding segment. In response to environmental stress and cytokines such as TNFA, HGK appears to act through MAP3K7, MAP2K4, and MAP2K7 cascades to activate JNK and the c-JUN N-terminal transcriptional pathway. HGK may interact with the SH3 domain of NCK adapter proteins. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                      
[25714] "The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability. The biological function of this helicase has not yet been determined. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25715] "This gene encodes a ATP-dependent DNA helicase. The 13.3 kD RecQL4 protein belongs to the RecQ subfamily of helicases and contains an helicase domain with a potential ATP binding site, and the DEAH box. The RecQ4 gene is predominantly expressed in thymus and testis and at low levels in other organs such as heart, brain, placenta, pancreas, small intestine, and colon, indicating that the expression of RecQ4 gene is somewhat tissue-specific. The expression of RecQ4 gene is partially upregulated in the G1/S phase of cell cycle. RecQL4 functionally suppresses promiscuous genetic recombination and ensures accurate chromosome segregation. (Beghini A . RECQL4. Atlas Genet Cytogenet Oncol Haematol. October 2001."                                                                                                                                                                                                                                                          
[25716] "The gene was cloned by sequence similarity to known RecQ helicase genes. Northern blot analysis detected RECQL5 expression in almost all tissues tested, with notably strong expression in pancreas and testis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25717] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25718] "Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                          
[25719] "Histone deacetylase 2 (HDAC2), or transcriptional regulator homolog RPD3 L1, is highly homologous to the yeast transcription factor RPD3 (reduced potassium dependency 3) gene. As in yeast, human HDA2 is likely to be involved in regulating chromatin structure during transcription. It has been implicated to associate with YY1, a mammalian zinc-finger transcription factor, which negatively regulates transcription by tethering RPD3 to DNA as a cofactor. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25720] "Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. (LocusLink)"                                                                                                                                                                                                                                                                                     
[25721] "Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                    
[25722] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25723] "Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25724] "The CYP19A1 gene encodes Aromatase Cytochrome P450, which is a unique member of the cytochrome P450 enzyme superfamily that catalyzes formation of aromatic C18 estrogens from C19 androgens by desaturating ring A of the steroid. One of two components of the aromatase enzyme complex, aromatase is present in many tissues including skin, muscle, fat, and nerve, where it may contribute to sex-specific differences in cellular metabolism. The other component of aromatase is NADPH-cytochrome P450 reductase, which transfers reducing equivalents to P450(arom). Class I cytokines such as IL6 and IL11, as well as TNF-alpha, are important regulatory factors of this gene. (from OMIM 107910 and NCI)"                                                                                                                                                                                                                                                                               
[25725] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25726] "An enzyme that hydrolyzes N-acetyl groups."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25727] "This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                              
[25728] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25729] "This gene encodes microsomal epoxide hydrolase, a carcinogen-activating enzyme. The gene product plays an important role in both the activation and detoxification of exogenous chemicals such as polycyclic aromatic hydrocarbons. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25730] "Including 7 Alu repeats, the 51-kb 10-exon human ACPP Gene (HAP Family) encodes 386-aa 45-kD homodimeric prostatic acid phosphatase, which is synthesized under androgen regulation and secreted by the epithelial cells of the prostrate gland. Sequence comparison has indicated the presence of several polymorphisms. ACPP undergoes alternative splicing in the 3' UTR. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25731] "Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. (LocusLink)"                                                                                                                                                                                                                                                                                         
[25732] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25733] "This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25734] "Cytochrome P450 Family Genes encode Cytochrome P450 isozymes, hemoprotein components of the mixed-function oxidase system involving electron and/or hydrogen transport through reversible valency change of the heme iron and metabolic biotransformation of substances, including foreign compounds to mutagens and carcinogens. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25735] "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                         
[25736] "The CYP2C18 gene encodes Cytochrome P450, Family 2, Subfamily C, Polypeptide 18, a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25737] "Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. (LocusLink)"                                                                                                                                                                                                                                                                                                                                        
[25738] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25739] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25740] "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. (from LocusLink)"                                                                                                                                                                                                                                                   
[25741] "This gene, CYP1A2, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. (from LocusLink)"                                                                                                                                                                                                                                                                                                  
[25742] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25743] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25744] "Expressed in many peripheral tissues (high in placenta), human HSD17B2 Gene (SDR Family) at 16q24.1-q24.2 encodes 387-aa 43-kDa Hydroxysteroid 17-Beta Dehydrogenase 2, a potential type II membrane protein enzyme with an N-terminal type II signal-anchor motif and a C-terminal ER retention motif, likely associated with ER membranes, that uses NADH in the oxidative inactivation metabolism of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 also has 3-beta-HSD activity and 20-alpha-HSD activity toward 20-alpha-dihydroprogesterone. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                              
[25745] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25746] "Human housekeeping G6PD Gene (G6PD Family) at Xq28 encodes 2 alternative isoforms of 514-/560-aa 59-kDa homodimeric or homotetrameric cytosolic Glucose-6-Phosphate Dehydrogenase, which mainly produces NADPH, an electron donor to oxidizing agents and in biosynthetic reactions. G6PD deficiency may cause jaundice, hemolysis, or non-spherocytic hemolytic anemia. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25747] "Human TPO Gene (XPO Family) encodes multiple (at least 8) alternative isoforms of glycosylated type I membrane-bound heme glycoprotein Thyroid Peroxidase, containing an EGF-like domain and cleaved in its N-terminal part. Important for TPO delivery to the cell surface, heme is covalently bound through an H(2)O(2)-dependent autocatalytic process. TPO catalyzes iodination of thyroglobulin tyrosines and phenoxy-ester coupling of the hormonogenic tyrosines to generate thyroid hormones, thyroxine (T3) and triiodothyronine (T4). TPO mutations are associated with disorders of thyroid hormonogenesis: hypothyroidism, Graves' disease, TIOD. (NCI)"                                                                                                                                                                                                                                                                                                                                
[25748] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25749] "Proteins found in any species or strain of mouse."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25750] "The chemical reactions and physical changes involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e. g. a xenobiotic chemical, such as a pesticide. (Gene Ontology)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25751] "Proteins found in any species or strain of rat."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25752] "Expressed in T- and NK cells, human ZAP-70 Gene (SYK/ZAP70 Family) encodes 619-aa 70-kDa Zeta-Chain Associated Protein (tyrosine) Kinase, containing 2 SH2 domains that bind to tyrosine phosphorylated ITAM of the TCR zeta chain upon TCR stimulation, which mediates transduction of stimuli to cellular effectors in lymphocyte activation. Associated with the zeta chain, ZAP70 undergoes tyrosine phosphorylation following TCR stimulation; Tyr-319 phosphorylation is essential for full activity. Following TCR ligation, a CRKL/WIP/WASP complex is recruited by ZAP70 to lipid rafts and immunologic synapses. Phosphorylated ZAP70 interacts with CBL, SLA, and SLA2; the association probably leads to its destruction. ZAP70 defects cause Selective T-Cell Defect. (NCI)"                                                                                                                                                                                                           
[25753] "Human SYK Gene (SYK/ZAP-70 Family) at 1q12-q23 encodes alternative (635-aa, 72-kDa and 612-aa) isoforms of autophosphorylated cytosolic Spleen Tyrosine Kinase, a positive effector of BCR-stimulation, containing 2 SH2 domains, and related to ZAP-70 (T cell activation). BCR associated SYK is tyrosine phosphorylated and activated by B cell stimulation. SYK couples BCR to Ca2+ mobilization through a PI3K pathway when (linker region) not Tyr phosphorylated or through a PLC-G pathway, when Tyr phosphorylated. SYK phosphorylation enhances PLC-gamma phosphorylation. Differential SYK phosphorylation can regulate BCR-coupled calcium pathways. Phosphorylated SYK interacts with CBL and SLA; SLA interaction may link it to CBL, a negative adapter protein regulator of BCR-calcium signaling. SYK Tyr phosphorylation creates a c-CBL binding site.  (NCI)"                                                                                                                    
[25754] "The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis.  It is a drug target in the pyrimidine biosynthetic pathway.  Variation in gene expression or sequence may alter the efficacy of chemotherapy. (from LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25755] "This gene encodes dihydrofolate reductase that converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids.  It is a drug target.  Variation in gene expression or sequence may alter the efficacy of chemotherapy. (from LocusLink and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25756] "Human BLK Gene (SRC Family) encodes (p55) B Lymphoid Tyrosine Kinase, a non-receptor protein tyrosine kinase in B-lymphoid cells activated within seconds after crosslinking the mIg complex that likely functions in a signal transduction pathway specific to this lineage. Expression of BLK in immature T-cells suggests that it may also play a role in thymopoiesis. The protein has SH3, SH2, and catalytic domains that contain SRC tyrosine kinase family consensus sequences. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25757] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25758] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25759] "Encodes dihydropyrimidine dehydrogenease, an enzyme involved in pyrimidine catabolism. Increased DPD levels can influence tumor response to 5-fluorouracil-based chemotherapy through increased inactivation of the agent in tumor cells. Increases of the DPD mRNA level in cancerous tissue seem to reflect tumor progression. High DPD mRNA levels in liver metastasis and advanced colorectal cancer may have clinical importance for 5-fluorouracil-based chemosensitivity. (from Ann Surg Oncol 2002;9:599-603)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25760] "This gene encodes disintegrin and metalloprotease (ADAM) domain 15, which is a member of the ADAM protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein member contains an RGD tripeptide in its disintegrin domain, and the specific interaction of the recombinant ADAM15 with integrin alpha5beta3 is RGD-dependent, suggesting that this protein may be involved in alpha5beta3-mediated cell-cell adhesion. (LocusLink)"                                                                                                                                                                                                                                                                                                           
[25761] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25762] "Containing STRPs and a polymorphic Alu, 32.5-kb human PLAT Gene (Peptidase S1 Family) at 8p12 encodes Tissue Plasminogen Activator 1 (562-aa, 63-kD), 2 (291-aa), and 3 (516-aa). Frameshifted variant 2 (lacks Ex9-11) has a distinct C-terminus; variant 3 lacks Ex4. EGF-like, fibronectin I, and kringle domains mediate fibrin, LRP1, annexin II, and cytokeratin 8 binding. TPA also binds to laminin, fibronectin, and mannose receptor. Inhibited by PAI-1, serine protease TPA is widely expressed as an active single chain, then secreted, and cleaved by plasmin, tissue kallikrein, or factor XA to a fully active disulfide linked A/B-protein; N-heavy chain and C-light chain. Important in cell migration and tissue remodeling, TPA activates (increased by fibrin or heparin) plasminogen to fibrinolytic plasmin conversion by hydrolyzing a specific Arg-Val bond. Altered activity causes hyper- or hypofibrinolysis. (from LocusLink, Swiss-Prot, OMIM, and NCI)"            
[25763] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25764] "A classification that includes Proteins, Functional RNAs, Protein Complexes, and Riboprotein Complexes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25765] "The product of so-called RNA genes; a functional RNA represents the final product of a gene rather than a transient molecule that will be translated into protein."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25766] "Expressed in brain (4.4-kb transcript) and testis (1.9-kb transcript), human NRG3 Gene (NRG Family) at 10q22 encodes conserved 720-aa Neuregulin 3, a soluble growth and differentiation factor and a type I membrane protein containing 2 hydrophobic segments similar to the transmembrane domain and internal signal sequence in NRG1. NRG3 also contains an N-Ala/Gly-rich segment, an EGF motif, and a mucin-like Ser/Thr-rich region with sites for O-linked glycosylation. Membrane-bound NRG3 may be inactive. Preceded by extensive glycosylation, external proteolytic cleavage close to the plasma membrane may involve dimerization of the intracellular domain. A ligand for ERBB4 receptor tyrosine kinase (likely via the EGF-like domain), NRG3 does not bind to ERBB2, ERBB3, or EGF receptor. The ERBB4 binding sites of NRG1 and NRG3 may overlap. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                  
[25767] "These genes encode caspases, a family of intracellular cysteine proteinases involved in inflammation and apoptosis. These enzymes appear to be involved in the initial signaling events, as well as the downstream proteolytic cleavages, that result in apoptotic cell death. They are specific for aspartic acid at the P1 position and are divided into two classes based on the lengths of their N-terminal pro-domains. Caspases-1, -2, -4, -5, -8, and -10 have long pro-domains while caspases-3, -6, -7, and -9 have short pro-domains. (from Science 1998. 281:1312 and Br Med Bull 1997. 53:478)"                                                                                                                                                                                                                                                                                                                                                                                         
[25768] "The CASP1 gene at 11q23 encodes Caspase-1, a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interlukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of the similar gene in mouse suggested its role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. (From LocusLink)"                           
[25769] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25770] "Human DNTT Gene encodes Terminal deoxynucleotidyltransferase, a unique DNA polymerase that without template direction catalyzes the addition of deoxyribonucleotides onto the 3-prime-hydroxyl end of DNA primers. TDT catalyzes the insertion of nucleotides (N regions) at the V(H)-D and D-J(H) junctions of immunoglobulin genes. The enzyme is present in immature thymocytes, some bone marrow cells, transformed pre-B and pre-T cell lines, and leukemia cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25771] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25772] "Human PRIM1 Gene (Eukaryotic Primase Small Subunit Family) encodes 420-aa 49-kDa Primase Polypeptide 1, the small subunit of heterodimeric DNA Primase. Eukaryotic DNA replication involves a chromosomal replication apparatus containing key enzymatic components DNA Primase and DNA Polymerase Alpha. DNA Primase is a polymerase that synthesizes small RNA primers for Okazaki fragments made during discontinuous DNA replication. Zinc bound to a PRIM1 zinc knuckle motif appears be involved in sequence recognition and binding of ssDNA. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25773] "The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus.  Two of the enzymes that are part of this machinery are DNA polymerase alpha (POLA), the principal replication enzyme, and primase, the enzyme that catalyzes the synthesis of oligoribonucleotide primers on a DNA template; the primers are required by DNA polymerase alpha to initiate DNA synthesis.  These 2 proteins form an enzymatic complex Primase, in turn, is a complex of two proteins, a 49kDa subunit and a 58kDa subunit.  This gene encodes the 58kDa subunit.  (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                            
[25774] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25775] "The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus.  Two of the enzymes that are part of this machinery are DNA polymerase alpha (POLA), the principal replication enzyme, and primase, the enzyme that catalyzes the synthesis of oligoribonucleotide primers on a DNA template; the primers are required by DNA polymerase alpha to initiate DNA synthesis.  These 2 proteins form an enzymatic complex Primase, in turn, is a complex of two proteins, a 49kDa subunit and a 58kDa subunit.  Mutation of the 58kDa subunit suggests that it is important for initiation, elongation, and counting.  (from OMIM and Biochemistry 2002;41:4891-900)"                                                                                                                                                                                                                                                                                         
[25776] "Encoded by human PRIM1 Gene (Eukaryotic Primase Small Subunit Family), 420-aa 49-kDa Primase Polypeptide 1 is the small subunit of heterodimeric DNA Primase. Eukaryotic DNA replication involves a chromosomal replication apparatus containing key enzymatic components DNA Primase and DNA Polymerase Alpha. DNA Primase is a polymerase that synthesizes small RNA primers for Okazaki fragments made during discontinuous DNA replication. Zinc bound to a PRIM1 zinc knuckle motif appears be involved in sequence recognition and binding of ssDNA. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25777] "A nitrosourea with potential antineoplastic activity.  Used experimentally as a mutagen and carcinogen, ethylnitrosourea alkylates DNA and proteins, thereby damaging DNA and inducing point mutations. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25778] "This gene encodes, fatty acid synthase (FAS), a key metabolic enzyme catalyzing the synthesis of long-chain saturated fatty acids. It plays a central role in the production of surfactant in fetal lungs, in the supply of fatty components of milk, and in the conversion and storage of energy in liver and adipose tissue. Remarkably high levels of FAS expression are found in the majority of human epithelial cancers.  Experimental manipulation suggests a link between FAS overexpression and dysregulation of membrane composition and functioning in tumor cells. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. (from Biochem Biophys Res Commun 2003;302:898-903 and LocusLink)"                                                                                                                                                      
[25779] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25780] "The CASP2 gene at 7q34-q35 encodes Caspase-2, a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspase-2 is synthesized as an inactive proenzyme which is activated by an alternative CD 95 pathway which involves the formation of a complex between oligomerized CD 95 and the accessory proteins RIP and RAIDD. After activation, caspase 2 induces apoptosis by triggering the caspase cascade. The proteolytic cleavage of this caspase is induced by a variety of apoptotic stimuli. In contrast to caspase 8, caspase 2 contains no death effector domain. (From LocusLink and NCI)"                                                                                                                                                                                                                                                                    
[25781] "NMT2 encodes N-myristoyltransferase 2 and its expression was direct responses to carcinogen exposure. Because inappropriate protein NH(2)-terminal myristoylation appears to play a role in carcinogenesis, induction of NMT2 may play a central role in dioxin carcinogenicity. (from Cancer Res 2001;61:8534-9)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25782] "CREB-binding protein, a 265 kD member of a family of transcription factor co-activators now referred to as p300/CBP.  Originally identified as a nuclear protein bound by the Protein Kinase A-phosphorylated form of CREB (cAMP responsive element binding protein)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25783] "EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CREB-binding protein (CBP), and like CPB can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25784] "This gene encodes histone acetyltransferase 1. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46 (RBBP7). The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25785] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25786] "CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation. The PCAF gene encodes p300/CBP-Associated Factor, which displays in vivo binding activity with CBP and p300. This protein has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that it plays a direct role in transcriptional regulation. It also associates with NF-kappa-B p65. Protein kinase A regulates the transcriptional activity of NF-kappa-B by modulating its interaction with CPB/p300. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                          
[25787] "The CASP3 gene at 4q34 encodes Caspase-3, a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Caspase-3 is a central player in mediating apoptosis and is the most widely studied caspase. This protein cleaves and activates caspases 6, 7 and 9, and itself can be processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants which encode the same protein. (From LocusLink and NCI)"                                                                                        
[25788] "HTATIP was originally isolated as an HIV-1 TAT-interactive protein. It encodes TIP60 protein which is a histone acetylase and plays a role in DNA repair and apoptosis. (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25789] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25790] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25791] "Expressed by glia and neurons, human FGF9 Gene (FGF family) encodes 208-aa 23-kDa (precursor) N-glycosylated monomeric secreted Fibroblast Growth Factor 9, with glial growth-stimulating effects and likely involved in glial cell growth and differentiation, gliosis, and differentiation or survival of neuronal cells. Three molecular species of 30-kDa, 29-kDa and 25-kDa, cleaved at Leu-4, Val-13 and Ser-34 respectively, are found. Expression may be dependent on Sonic hedgehog signaling. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25792] "One of three genes nested in PCDH15 introns, 8-kb human PLAU Gene (Peptidase S1 Family) at 10q24 encodes a 431-aa 48.5-kD single-chain Urokinase precursor containing a kringle and EGF-like domain. A potent activator of plasminogen to plasmin conversion by Arg-Val cleavage, the two-chain serine protease is composed of disulfide-linked A (18,000 D) and B (33,000 D) chains that arise from precursor Lys(158)-Ile(159) cleavage by plasmin. Urokinase occurs in high and low mass forms, each consisting of A and B chains. The high mass form contains a long A chain; cleavage after residue 155 in the low mass form yields a short A1 chain. Urokinase is immunologically unrelated to TPA. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                              
[25793] "Expressed primarily in fibroblasts, 73-kb human FAP Gene (Peptidase S9B Family) at 2q23 (near DPP4) encodes inducible Fibroblast Activation Protein, Alpha major isoform 1 (Long, 760-aa, 87.8-kD) and truncated isoform 2 (Short, 239-aa). FAPA is similar to DPP4 and DPPX. Heterodimeric (with DPP4) or homodimeric, N-glycosylated FAPA is a type II integral membrane protein gelatinase: 13 extracellular cysteine residues and 3 conserved serine protease domains, a transmembrane segment, and a short cytoplasmic tail. Monomer is inactive. On lamellipodia, FAPA appears involved in epithelial-mesenchymal interactions during development, tissue repair/remodeling, epithelial carcinogenesis, and malignant invasion. A product of the same gene, monomeric N-glycosylated Seprase is composed of proteolytically inactive subunits whose activities depend on subunit association. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                    
[25794] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25795] "One of several kallikrein genes, 7-kb human KLK2 Gene (Kallikrein Family) at 19q13.41 encodes alternative Prostatic Kallikrein 2 isoforms: 1 (261-aa, 28.7-kD prepropeptide), 2 (PGK-10A, 222-aa), 3 (164-aa). The mature serine protease is 237 amino acids. About 12-kb apart, KLK2 and APS are aligned head-to-tail. The glandular kallikrein family may comprise 25-30 genes that encode specific proteases involved in processing of active peptides. KLK2 exhibits 66% and 73% homology with KLK1 and APS. Glandular kallikreins release vasoactive peptides from kininogen; the kininogenase activity of different kallikreins is highly variable. Kallikrein 2 cleaves kininogen Met-X, Arg-X, or Leu-X bonds to release lys-bradykinin (kallidin) involved in vasodilation and smooth muscle contraction. The physiologic role of specific kallikreins is often unrelated to the kininogenase activity. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                       
[25796] "Regulated by androgens and one of 15 clustered kallikrein genes, 5-exon 6-kb human KLK3 Gene (Kallikrein Family) at 19q13.41 generates alternate isoforms of a single-chain 261-aa 30-kD (precursor) Kallikrein 3 glycoprotein (Prostate Specific Antigen); additional variants may exist. Using an alternate coding region splice site, frameshifted isoform 2 has a shorter distinct C-terminus. AREs reside in the KLK3 proximal promoter; distal AREs and a cell-specific enhancer map upstream. A serine protease in seminal plasma, PSA may function in liquefaction of seminal coagulum by (preferential Tyr-X) cleavage of seminal vesicle protein. Kallikrein proteases have diverse functions. Mounting evidence implicates kallikreins in carcinogenesis; some have potential as cancer biomarkers. The serum level of PSA is useful in diagnosis and monitoring of prostatic carcinoma. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                    
[25797] "Expressed in prostate, kidney, lung, small intestine, stomach, colon, placenta, spleen, liver, leukocytes, and thymus, 51-kb human ST14 Gene (Peptidase S1 Family) at 11q24-q25 generates a 3.3-kb transcript that encodes an 855-aa 95-kD membrane-associated serine protease, Matriptase. ST14 contains an N-region integrin-binding site, N-glycosylation sites, tandem LDLR class A cysteine repeats, CUB domains, a putative proteolytic activation site, a C-terminal trypsin-like serine protease region, an S1 pocket, an S2 subsite, and an S4 cavity. Protease specificity involves additional cleavage site residues. Complexed with 40-kD SPINT1, a Kunitz-type inhibitor, ST14 is activated by sphingosine 1-phosphate, degrades extracellular matrix, and cleaves/activates HGF and urokinase plasminogen activator. ST14 may play a role in cancer invasion and metastasis. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                             
[25798] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25799] "Expressed in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus, and kidney epithelia, 4.4-kb 6-exon single-copy human PRSS8 Gene (Peptidase S1 Family) at 16p11.2 encodes secreted or membrane anchored 343-aa 36-kD (precursor) Serine Protease-8, similar to acrosin, plasma kallikrein, hepsin, and xCAP1 (Xenopus). Five-prime regulatory elements include an AP2 site, erythroid-specific elements, a sterol regulatory element, a variant GC box, and an AP1 site; no TATA box is found. The proprotein is cleaved (aa 12-13) to produce disulfide-linked light and heavy chains. The C terminal hydrophobic region is cleaved (aa 290-291) during secretion. Likely involved in semen coagulation and liquefaction, PRSS8 is active with trypsin-like specificity on Lys or Arg carboxyl peptide linkages. Prostasin may regulate ENaC. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                  
[25800] "Located in a cluster and coordinately expressed with closely related ELA2 and AZU during myeloid development, 5-exon 7-kb human PRTN3 Gene (Peptidase S1 Family) at 19p13.3 responds to G-CSF; the promoter contains PU.1, C/EBP, and c-MYB sites. Packed in neutrophilic azurophil granules, the encoded 256-aa 29-kD Proteinase 3 precursor is an antibiotic neutral serine protease that appears to degrade elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV by preferential cleavage at Ala-X and Val-X bonds. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                                                                                                                                                        
[25801] "The single 18-exon (44-153 bp; all GT/AG splice sites) 40-kb human GPI Gene (GPI Family) at 19q13.1 encodes Glucose-6-Phosphate Isomerase, Neuroleukin, and Autocrine Motility Factor. The protein functions in different capacities. In glycolysis and gluconeogenesis, homodimeric cytoplasmic GPI catalyzes reversible G6P and F6P isomerization. Produced by lectin-stimulated T-cells, secreted non-mitogenic NLK lymphokine acts early in antibody-secreting cell formation to induce Ig secretion. Also a neurotrophic factor for spinal and sensory neurons, NLK exhibits GPI activity. AMF is a 558-amino acid 55-kD autocrine motility polypeptide. The gene product is partly homologous to a conserved region of HTLV-III-LAV external envelope protein. Gene defects cause nonspherocytic hemolytic anemia and hydrops fetalis. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                           
[25802] "The single-copy 95.7-kb human TOP1 Gene (TOPI Family) at 20q12-q13.1 contains 0.2-30 kb introns and 21 exons that encode 765-aa 90.7-kD monomeric DNA Topoisomerase I, which catalyzes transient ATP-independent breaking/rejoining of DNA and controls DNA topology during transcription. Mouse Top-1 exhibits a similar exon-intron structure. Two truncated pseudogenes occur in the human genome; one pseudogene exists in the mouse genome. DNA topoisomerases I and II relax negative and positive supercoils; TOP1 breaks single DNA strands, TOP2 breaks duplex DNA. Specifically inhibited by the antitumor plant alkaloid CPT, when TOP1 breaks the DNA backbone bond it forms a protein-DNA link (a tyrosyl oxygen joins to a DNA strand end phosphorus). (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                   
[25803] "Linked to ERBB2, single-copy 35-exon 30-kb human TOP2A Gene (TOPII Family) at 17q21-q22 encodes alternative homodimeric nuclear DNA Topoisomerase II, Alpha isoforms 1 (1531-aa, 174.4-kD), 2 (1557-aa), 3 (1567-aa), and 4 (1612-aa). TOPII alpha and beta appear derived from duplicate independently expressed genes. Controlling DNA topology, TOP2A catalyzes transient ATP-dependent double-strand breakage/relaxation and rejoining of negative/positive supercoiled DNA during transcription, replication, chromosome condensation, and chromatid separation. TOPII reactions likely involve crossing-over. TOP2A is associated with Pol II holoenzyme. Inhibited by intercalating amsacrine, TOP2A is a target for several anticancer agents. Mutations are linked with drug resistance and perhaps ataxia-telangiectasia. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                    
[25804] "The 36-exon 67-kb human TOP2B Gene (TOPII Family) at 3p24 encodes alternative homodimeric nuclear DNA Topoisomerase II, Beta isoforms: 2 (1626-aa, 183-kD) and 1 (1621-aa). TOPII beta and alpha appear derived from duplicate independently expressed genes. Controlling DNA topology, TOP2B catalyzes transient ATP-dependent double-strand breakage/relaxation and rejoining of negative/positive supercoiled DNA during transcription, replication, chromosome condensation, and chromatid separation. With 72% similarity in TOP2, TOP2A/B N-terminal ATPase and central breakage/reunion domains are conserved; the C-terminal domains differ markedly. The TOP2B C-terminus contains potential phosphorylation sites. TOP2B is a target for several anticancer agents. Mutations are linked with drug resistance and perhaps ataxia-telangiectasia. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                             
[25805] "Mapped between D17S447 and D17S258, 43.6-kb single-copy human TOP3 Gene (TOPI/III Family) at 17p12-17p11.2 is expressed in multiple somatic tissues (highest in testis, heart, skeletal muscle, pancreas) as long (1001-aa, 112-kD) and short (976-aa) alternative DNA Topoisomerase III Alpha isoforms that share no homology with DNA TOPI. TOP3A catalyzes transient ATP-independent breaking/rejoining of single DNA strands, reducing negative supercoils and controlling DNA topology during transcription. The enzyme forms a complex with BLM (aa 1-133 of BLM), which recruits TOP3A to PML nuclear bodies and regulates somatic sister chromatid recombination. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                                                                                                                                                                              
[25806] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25807] "The 20-40-kb (11 coding exons) human PTGS1 Gene (PGHS Family) at 9q32-q33.3 encodes alternative homodimeric monotopic ER membrane Prostaglandin-Endoperoxide Synthase 1 isoforms with an EGF-like domain and identical N/C-regions in a constitutive 2.8-kb mRNA: long (599-aa, 69-kD precursor) and short (562-aa). COX3 (5-kb) and PCOX1A (deleted Ex5-8, lacking COX activity) mRNAs retain a conserved intron 1 ORF, altering the signal peptide (uncleaved) in the glycosylated membrane peptides. Rate-limiting in prostaglandin and thromboxane synthesis, bifunctional PTGS1 appears involved in cell signaling, angiogenesis, and tissue homeostasis. PGH COX activity converts arachidonate to PGG2; PGH peroxidase converts PGG2 to PGH2. COX1 is inhibited by NSAIDs such as aspirin (irreversible ser529 acetylation). (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                                                    
[25808] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25809] "The cytokine/mitogen-induced 4.5-kb mRNA of 7.5-8.5kb 10-exon human PGHS2 Gene (PGHS Family) at 1q25.2-q25.3 encodes homodimeric microsomal membrane 604-aa 69-kD (precursor) Prostaglandin-Endoperoxide Synthase 2, with 1 EGF-like domain, involved in prostanoid-induced inflammation and mitogenesis (86-89% identity with mammalian PTGS2 proteins). LPS, PMA, IL1-Beta, hCG, LH and glucocorticoids regulate PGHS2 expression. 3-Prime UTR AU-rich repeats bind to CUGBP2 facilitating mRNA stability and translation inhibition. A target of NSAIDs, rate-limiting PGHS2 dioxygenase and peroxidase activity converts arachidonate to prostaglandins and thromboxanes. COX2 induction stimulates peripheral nociceptors. Deregulated expression may enhance carcinogenic potential; weak expression in pheochromocytomas favors benign diagnosis. (from LocusLink, Swiss-Prot, OMIM, and NCI)"                                                                                               
[25810] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25811] "This gene encodes platelet factor-4, a 70-amino acid CXC chemokine. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. (from OMIM)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25812] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25813] "Encoded by human FOSB Gene, FOSB is a leucine zipper protein that can dimerize with proteins of the JUN family, forming transcription factor complex AP-1. As such, FOSB appears to be a regulator of cell proliferation, differentiation, and transformation. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25814] "A member of the Fos gene family.  This family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25815] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25816] "This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                          
[25817] "A product of the PPBP gene, pro-platelet basic protein is processed into platelet basic protein (PBP) and connective-tissue-activating peptide III (CTAP-III).  Upon platelet activation these proteins undergo further processing into beta thromboglobulin (Beta-TG) and neutrophil-activating peptide 2 (NAP2), respectively.  Many of the function ascribed to CTAP-III may actually be the result of processing to NAP-2."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25818] "Human PPBP Gene (Alpha Chemokine CXC Family) encodes secreted 128-aa 14-kDa (precursor) Pro-Platelet Basic Protein, a platelet-derived growth factor that is processed to PBP and CTAP-III. Proteolytic removal of PPBP residues 1-9 produces active peptide CTAP-III/LA-PF4, which stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and sythesis of hyaluronic acid and sulfated glycosaminoglycan, as well as formation and secretion of plasminogen activator. Upon platelet activation, PBP is proteolytically converted to beta thromboglobulin, a homotetramer released when platelets aggregate; CTAP-III is proteolytically converted to NAP2, a potent chemoattractant and activator of neutrophils. (NCI)"                                                                                                                                                                                                                     
[25819] "Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases that include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Encoded by human ACVR1 Gene, Activin A Receptor Type I signals a particular transcriptional response in concert with activin type II receptors. (LocusLink)"                                   
[25820] "Activin A receptor, type II-like 1 (also called activin receptor-like kinase 1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The ACVRL1 gene encodes a protein that shares similar domain structures with 3 other closely related ALK proteins (ALK2, ALK3, and ALK4) that together form a subfamily of receptor serine/threonine kinases. ACVRL1 is most highly expressed in human placenta and lung. ACVRL1 deficiency causes hemorrhagic telangiectasia type 2 (HHT2) also known as Rendu-Osler-Weber syndrome 2 (ORW2). (NCI)"                                                                                                                                                                                                        
[25821] "Encoded by human PPBP Gene (Alpha Chemokine CXC Family), secreted 128-aa 14-kDa (precursor) Pro-Platelet Basic Protein is a platelet-derived growth factor that is processed to PBP and CTAP-III. Proteolytic removal of PPBP residues 1-9 produces active peptide CTAP-III/LA-PF4, which stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and sythesis of hyaluronic acid and sulfated glycosaminoglycan, as well as formation and secretion of plasminogen activator. Upon platelet activation, PBP is proteolytically converted to beta thromboglobulin, a homotetramer released when platelets aggregate; CTAP-III is proteolytically converted to NAP2, a potent chemoattractant and activator of neutrophils. (NCI)"                                                                                                                                                                                                               
[25822] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25823] "The RRM2 gene at 2p25-p24 encodes Ribonucleoside-Diphosphate Reductase M2 Chain, which is a subunit of ribonucleoside-diphosphate reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Synthesis of M2 is regulated in a cell-cycle dependent fashion. Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as M2 subunits. RRM2 gene amplification from a homogeneous staining chromosome region and altered transcription regulation is associated with drug resistance. (From LocusLink and NCI)"                                         
[25824] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25825] "Granules found in several types of cells, especially platelets, where they are the most numerous type of granule; contain secretory proteins."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25826] "Angiogenin is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease (RNS1). (LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25827] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25828] "Ribonucleoside-Diphosphate Reductase M2 Chain, encoded by the RRM2 gene, is a subunit of ribonucleoside-diphosphate reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Synthesis of M2 is regulated in a cell-cycle dependent fashion. Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as M2 subunits. RRM2 gene amplification from a homogeneous staining chromosome region and altered transcription regulation is associated with drug resistance. (From LocusLink and NCI)"                                                       
[25829] "The CASP8 gene at 2q33-q34 encodes Caspase-8, a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. Caspase-8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli. This protein is detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicates its role in neurodegenerative diseases. Alternative splicing of this gene results in five transcript variants. (From LocusLink and NCI)"                                                            
[25830] "IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. (from LocusLink)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25831] "Encoded by human IRF2 Gene (IRF Family), transcription factor Interferon Regulatory Factor 2 competitively inhibits IRF1-transcriptional activation of interferons alpha and beta, and perhaps other IRF1-activated genes. IRF2 also functions as a transcriptional activator of histone H4. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25832] "Encoded by human IRF1 Gene (IRF Family), transcription factor Interferon Regulatory Factor 1 activates transcription of interferon genes alpha and beta, as well as genes induced by interferons alpha, beta, and gamma. IRF1 also regulates apoptosis and tumor-suppression. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25833] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25834] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25835] "Mammalian NADPH-cytochrome P450 reductase (CPR) was first identified by Horecker in 19501 as an NADPH-specific cytochrome c reductase.  CPR was linked to the microsomal electron transport chains, cytochromes P450 and b5, involved in drug and steroid hydroxylations in 1960's.  CPR is a flavoprotein containing both FAD and FMN.  It has a modular structure suggestive of its evolution from smaller subunits similar to flavodoxins and ferredoxin NADP+ reductase, and its 3-dimensional structure was recently determined.  It is involved in heme catabolism, sterol, bile acid synthesis and fatty acid metabolism.  CPR is also a component of nitric oxide synthases and methionine synthase reductase. (http://www.uky.edu/Pharmacy/ps/porter/CPR.htm)"                                                                                                                                                                                                                             
[25836] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25837] "Secreted Follistatin-Like 3 Glycoprotein binds to activin and is highly homologous to follistatin, an activin ligand. It is a member of the follistatin-module protein family, which is composed of extracellular matrix-associated glycoproteins thought to act in a paracrine manner to bind morphogens or growth/differentiation factors and regulate their activity during development. In addition to the t(11;19) translocation in a case of B-cell chronic lymphocytic leukemia from which FSTL3 was isolated, rearrangement of the FSTL3 gene was also observed in a case of B-cell non-Hodgkin lymphoma and in a case of B-cell mantle zone lymphoma, suggesting that FSTL3 may be involved in the leukemogenesis process.(OMIM)"                                                                                                                                                                                                                                                          
[25838] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25839] "Encoded by human BAIAP2 Gene, Brain-Specific Angiogenesis Inhibitor Binding Protein interacts at the cytoplasmic membrane with brain-specific angiogenesis inhibitor, which may be involved in neuronal growth-cone guidance. BAIAP2 protein functions as an insulin receptor tyrosine kinase substrate and interacts with the dentatorubral-pallidoluysian atrophy gene, associated with a neurodegenerative disease. BAIAP2 also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                   
[25840] "The BLNK gene at 10q23.2-q23.33 encodes B-Cell Linker, which is essential for normal B-cell development. BLNK interfaces the B-cell receptor-associated SYK tyrosine kinase with PLC-gamma, the VAV guanine nucleotide exchange factor, and the GRB2 and NCK adaptor proteins. Tyrosine phosphorylation of BLNK by SYK provides docking sites for these SH2-containing effector molecules that, in turn, permits the phosphorylation and/or activation of their respective signaling pathways. Thus, BLNK represents a central linker protein that bridges the B-cell receptor-associated kinases with a multitude of signaling pathways and may regulate biologic outcomes of B-cell function and development. The somatic loss of the BLNK gene and the accompanying block in pre-B-cell differentiation might be one of the primary causes of childhood pre-B ALL. (From OMIM and NCI)"                                                                                                          
[25841] "B-Cell Linker, encoded by the BLNK gene, is essential for normal B-cell development.  This protein interfaces the B-cell receptor-associated SYK tyrosine kinase with PLC-gamma, the VAV guanine nucleotide exchange factor, and the GRB2 and NCK adaptor proteins.  Tyrosine phosphorylation of B-Cell Linker by SYK provides docking sites for these SH2-containing effector molecules that, in turn permits the phosphorylation and/or activation of their respective signaling pathways.  Thus, B-Cell Linker represents a central linker protein that bridges the B-cell receptor-associated kinases with a multitude of signaling pathways and may regulate biologic outcomes of B-cell function and development.  The somatic loss of the BLNK gene and the accompanying block in pre-B-cell differentiation might be one of the primary causes of childhood pre-B ALL.  (From OMIM and NCI)"                                                                                                
[25842] "Ubiquitously expressed (highest in heart, skeletal muscle, and pancreas) by human IGBP1 Gene, 339-aa 39-kDa Immunoglobulin Binding Protein 1 is likely involved in IgM/B-Cell Receptor signal transduction. Similar to mouse Igbp1 and yeast TAP42, IGBP1 contains potential N-glycosylation sites, myristylation sites, multiple potential PKC and casein kinase II phosphorylation sites, and an SH3-binding sequence-related stretch. IGBP1 associates with and likely regulates the activity of Ser/Thr phosphatase PP2A-Alpha and PP2A-Beta catalytic subunits. IGBP1 also associates with PP4 and PP6. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                 
[25843] "A second generation purine nucleoside analog inhibiting DNA Polymerase and Ribonucleotide Reductase, causing inhibition of DNA and RNA synthesis, disruption of mitochondrial function, and apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25844] "A recombinant human erythropoietin, a glycoprotein hormone and haematopoietic growth factor, derived from cloned human erythropoietin gene containing 165 amino acids producing the same pharmacologic properties as endogenous erythropoietin, including regulation of erythropoiesis by stimulating differentiation and proliferation of erythroid precursors, stimulating release of reticulocytes and synthesis of cellular haemoglobin.  Clinical Use: Anemia related to Chemotherapy, Chronic Renal Failure, and HIV-Infected Patients, and Surgery Patients (Decreased need for transfusions).(NCI)"                                                                                                                                                                                                                                                                                                                                                                                         
[25845] "A peptide derived from cytomegalovirus (CMV) internal matrix protein pp65, CMV pp65 Peptide antigen is used in recombinant vaccinia virus as an HLA-A-restricted epitope to produce vaccines and specific cytotoxic T cell response against CMV infection, a serious complication of allogeneic bone marrow transplantation (BMT), prevented by passive immunization with donor-derived CMV-pp65-specific T-cell clones provided early post-BMT. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25846] "An azaspirodecanedione derivative acting as an anxiolytic agent by an unknown mechanism, but exhibits an affinity for D2-dopamine receptors, increases Norepinephrine metabolism in the locus ceruleus, and in vitro an affinity for serotonin receptors. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25847] "The d-threo-enantiomer of methylphenidate, a central nervous system stimulant, appearing to block the reuptake of norepinephrine and dopamine into the presynaptic neuron, increasing their availability in the extracellular space.  The mechanism of action in Attention Deficit Hyperactivity Disorder is unknown. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25848] "A combination of two synthetic agents with central nervous system stimulant activity.  Both agents are non-catecholamine, sympathomimetic agents that elevate blood pressure and cause bronchodilation.  Dextroamphetamine-amphetamine may be used to treat chemotherapy-related depression, to suppress appetite and control weight, to treat narcolepsy, and to treat attention-deficit hyperactivity disorder.  These agents are commonly abused psychostimulant drugs that induce psychologic dependence manifested by elevated mood, increased wakefulness, concentration, physical performance and a feeling of well-being.  Tolerance to various effects develops unequally, so that tachycardia and enhanced alertness diminish while psychotoxic effects (hallucinations and delusions) may occur. (NCI04)"                                                                                                                                                                                
[25849] "A synthetic analog of Halichondrin B inhibiting tubulin polymerization, causing inhibition of mitosis and cell replication. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25850] "A proprietary multi-epitope DNA vaccine containing tumor-associated antigen-specific cytotoxic T-cell epitopes, to induce T-cell response, and some epitopes modified by manipulating the amino acid sequence to create heteroclitic analogs, to enhance T-cell response.  In addition, the vaccine contains a proprietary universal T-cell epitope (PADRE) to enhance the extent and duration of CTL response.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25851] "A standardized ginkgo biloba extract exhibiting antioxidant and neuroprotective activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25852] "An herb (Actaea racemosa and Cimicifuga racemose) in the buttercup family sold as a dietary supplement in the United States containing saponins and exhibits estrogenic activity.  Preparations are made from extracts from its roots and rhizomes and are used in Alternative Medicine for rheumatism, gynecological disorders, lung and neurologic conditions.  (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25853] "A small molecule that targets intracellular tyrosine kinase activity selectively inhibiting Epidermal Growth Factor 2 (HER2) and designed to inhibit the growth of tumors dependent on HER2 oncogene, a regulator of cell growth, activity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25854] "An herbal tea remedy thought to be an ancient Canadian Ojibway Indian formula containing burdock root, turkey rhubarb root, sheep sorel, and slippery elm bark.  The burdock root and turkey rhubarb root are claimed to have antitumor activity and herbalists believe the combination of herbs act synergistically to treat various cancers.  No formal clinical trials have been done and the formulation is not approved in Canada or the United States.(NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25855] "Seeds from the flax plant containing significant amounts of soluble fiber, alpha-linolenic acid, and phytoestrogenic lignans, exhibiting antioxidant activity and possibly preventing Arteriosclerotic Cardiovascular Disease and cancer progression. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25856] "A Chinese herb derived from either the Panax ginseng, the Asian species, Panax quinquefolius, the American species, or P. pseudoginseng, known as Siberian or Russian ginseng, plant containing a complex mixture of saponins, ginsenosides and panaxosides, available as a nutritional supplement and is reported to enhance the immune system and reduce fatigue. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25857] "A 20-mer antisense oligonucleotide complementary to a coding region in the mRNA of the R2 small subunit component of human ribonucleotide reductase.  GTI-2040 decreases mRNA and protein levels of R2 in vitro and may inhibit tumor cell proliferation in human tumors in vivo. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25858] "A synthetic, orally-active quinazoline with potential antineoplastic properties. GW572016 reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts.  EGFR and ErbB2 have been implicated in the growth of various tumor types. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25859] "A precursor of photoactive porphyrins accumulating in neoplastic tissue for detection of malignant and pre-malignant lesions and when exposed to light therapy becomes activated, causing cell death. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25860] "A transition-state analog that selectively inhibits human T lymphocytes by inhibiting purine nucleoside phosphorylase, an enzyme involved with the degradation of deoxyguanosine, causing accumulation of deoxyguanosine and conversion into dGTP, an enzyme that inhibits ribonucleotide diphosphate reductase, blocking DNA synthesis and inducing apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25861] "A nutritional supplement containing two amino acids that support muscle protein synthesis, arginine and glutamine, and beta-hydroxy-beta-methylbutyrate (HMB), a chemical that minimizes muscle protein breakdown and increases membrane integrity, that may prevent muscle loss in AIDS and cancer patients.  Clinical trial: treatment of cachexia in patients with unspecified solid tumors or lymphoma with no leukemic aspect. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25862] "The L-form of carnitine, a naturally occuring metabolic agent that facilitates the entry of long chain fatty acid into the mitochondria for energy production. Levocarnitine supplementation raises the carnitine plasma levels. Current Use: Systemic Carnitine Deficiency in patients with end Stage Renal Disease and HIV, Chemotherapy-induced fatigue in non-anaemic cancer patients. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25863] "A macrocyclic bisindolylmaleimide that directly affects endothelial cells by inhibiting Protein Kinase C beta, causing antiangiogenic effects and preventing tumor growth. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25864] "Any part of, or extract from, the female hemp plant Cannabis sativa.  Marijuana contains cannabinoids, substances with hallucinogenic, psychoactive, and addictive properties.  This agent has potential use for treating cancer pain and cachexia. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25865] "An immunoconjugate comprised of a deimmunized monoclonal antibody (MLN591), targeting Prostate-Specific Membrane Antigen (PSMA), conjugated with a maytansinoid chemotherapeutic agent (DM1), a microtubule inhibitor, selectively binding to PSMA and delivering DM1 directly to the cancer cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25866] "A drug that is being studied as a treatment for fatigue in patients with cancer.  It belongs to the family of drugs called stimulants."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25867] "Nino extract from the fruit of the Morinda citifolia or the Indian mulberry plant that has antioxidant properties and has been used to treat various diseases including neoplasms. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25868] "An anthracycline that intercalates with DNA base pairs and causes tumor cell death with potentially reduced cardiotoxicity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25869] "Consists of Camptothecin, a topoisomerase I inhibitor, conjugated to polyglutamate polymer to enhance drug delivery to tumor cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25870] "Juice extracted from the Pomegranate fruit containing antioxidants, flavonoids, that may decrease the rise of prostate-specific antigen (PSA) levels and acts as a chemopreventive agent. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25871] "A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25872] "A synthetic derivative of hydroxyurea with antiasthmatic properties, leukotriene inhibitor Zileuton blocks 5-lipoxygenase, which catalyzes formation of leukotrienes (inflammation mediators) from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and prevents or decreases the symptoms of asthma. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25873] "An oral rinse comprised of N-acetylcysteine in a polymer matrix having antioxidant and anti-inflammatory properties for use in the prevention and treatment of oral mucositis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25874] "A vitamin D analogue, acting as a biological response modifier that inhibits cancer cell growth and induces cancer cell differentiation and apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25875] "An agent that selectively inhibits phosphodiesterase type 5, an enzyme responsible for the degradation of cyclic guanosine monophosphate (cGMP), increasing cGMP, causing relaxation of corpus cavernosal smooth muscle and increased blood flow to the cavernosal spaces resulting in penial erection. Clinical Use: Erectile Dysfunction, Clinical trial: Erectile Dysfunction in Patients with Prostate Cancer. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25876] "A mixture of flavonolignans extract from the milk thistle plant, Silybum marianum, acting as an antioxidant to protect liver cells from free radical damage and promoting the growth of new liver cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25877] "A Dolastatin 10 derivative that inhibits tubulin polymerization, causing cell cycle arrest and induction of apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25878] "An orally bioavailable indolinone with potential antineoplastic activity.  SU11248 blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation.  This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed in some leukemic cells. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25879] "A pentafluorophenyl-sulfonamide compound that inhibits tubulin polymerization by binding irreversibly to the colchicine binding sites, causing cell cycle arrest and induction of apoptosis. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25880] "A cytotoxic agent that is activated intratumorally upon exposure to light. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25881] "A synthetic targeted protein toxin which consists of human transferrin (Tf) conjugated to a diphtheria toxin that contains a point mutation (CRM107). Tf-CRM107 inhibits protein synthesis and may be is cytotoxic for mammalian cells expressing the transferrin receptor. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25882] "A biological response modifier that up regulates macrophages function and improves their ability to inhibit tumor cell growth and cause cytotoxicity. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25883] "An orally selective endothelin A (ETA) receptor antagonist that controls pain by blocking the effect of endothelin, a naturally occurring substance involved in the pain process and elevated in cancer cells. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25884] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25885] "An immunogenic cancer antigen that is used in vaccine therapy to elicit antigen-specific CD8 positive T-cell response. (NCI)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25886] "An immunogenic peptide derived from the human papillomavirus (HPV). Used to design prophylactic or therapeutic vaccines against HPV infection and HPV-related neoplasms, the HPV 18E6 peptide cross-reacts immunologically with both HPV type 16 and HPV type 18, the most common HPV types involved in cervical cancer. Vaccination with HPV 18E6 may result in increases in T cell-proliferative responses to HPV, as well as significant increases in cytokine responses to HPV antigens. (NCI04)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25887] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25888] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25889] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25891] "An enclosed collection of pus in tissues, organs, or confined spaces in the body.  An abscess is a sign of infection and is usually swollen and inflamed."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[25892] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25893] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25894] "disease characterized by hypotension, weight loss, anorexia, weakness, and sometimes a bronze-like melanotic hyperpigmentation of the skin; due to tuberculosis or autoimmune induced disease (hypofunction) of the adrenal glands that results in deficiency of aldosterone and cortisol."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25895] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25896] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25897] "deficiency or absence of fibrinogen (coagulation factor I) in the blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[25898] "protruding sac in the wall of a vein, artery, or heart, frequently caused by microbial infection; may present as pain, pressure on nearby organs, or cardiac weakening."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25899] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25900] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25901] "Apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25902] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25903] "Apnea; transient cessation of respiration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[25904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25906] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25907] "Loss of muscle coordination."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25910] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25911] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25912] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25913] "Drooping of the upper eyelid."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25914] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25915] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25916] "A condition in which Candida albicans, a type of yeast, grows out of control in moist skin areas of the body. It is usually a result of a weakened immune system, but can be a side effect of chemotherapy or treatment with antibiotics. Thrush usually affects the mouth (oral thrush); however, rarely, it spreads throughout the entire body. Also called Candidiasis or thrush."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25917] "(MYOO-sin-us kar-sin-O-ma) A type of cancer that begins in cells that line certain internal organs and produce mucin (the main component of mucus)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25918] "Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness.  Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Diagnostic Surgical Pathology, 3rd ed.) --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25919] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25920] "An acute, spreading infection of the deep tissues of the skin and muscle that causes the skin to become warm and tender and may also cause fever, chills, swollen lymph nodes, and blisters."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25922] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25923] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25924] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25927] "condition characterized by persistent coughing, increased secretion from the bronchial mucosa, obstruction of the respiratory passages, scanty or profuse expectoration, and necrosis and fibrosis of the respiratory tract."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[25928] "An acute or chronic inflammation of the colon caused by viruses (e.g. cytomegalovirus), bacteria (e.g. ameba) or immunologic factors (inflammatory bowel disease which includes Crohn's colitis and ulcerative colitis). -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25929] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25931] "A disorder resulting from the presence and activity of a microbial, viral, or parasitic agent. It can be transmitted by direct or indirect contact. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25932] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25933] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25934] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25935] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25936] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25937] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25938] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25939] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25940] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25941] "A condition characterized by the presence of cryoglobulins in the blood. Cryoglobulins are abnormal proteins that precipitate within the microvasculature on exposure to cold; microvasculature effects of cryoglobulinemia may result in restricted tissue blood flow, tissue hypoxia, and tissue necrosis. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25942] "Blue-colored skin caused by too little oxygen in the blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25943] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25944] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25945] "A condition caused by the loss of too much water from the body.  Severe diarrhea or vomiting can cause dehydration."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[25946] "False personal beliefs held contrary to reality, despite contradictory evidence and common sense."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25947] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25948] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25949] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25950] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25951] "A chronic disorder marked by hardening and thickening of the skin.  Scleroderma can be localized or it can affect the entire body (systemic)."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[25952] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25953] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25954] "An often clinically aggressive endocrine neoplasm located in the pancreas or small intestine.  It is composed of cells containing vasoactive intestinal peptide.  It may cause intractable diarrhea and metabolic disturbances. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25955] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25956] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25957] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25958] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25960] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25961] "Upset stomach."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25963] "A small bruise caused by blood leaking from broken blood vessels into the tissues of the skin or mucous membranes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25964] "(EM-bul-izm) A block in an artery caused by blood clots or other substances, such as fat globules, infected tissue, or cancer cells."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[25965] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25966] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25968] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25969] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25970] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25971] "Epistaxis; bleeding from the nose."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[25972] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25973] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25974] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25975] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25976] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25977] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25979] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25980] "Flushing; sudden reddening of the face."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25981] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25982] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25984] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25985] "Gastritis; inflammation of the lining of the stomach."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[25986] "(GAS-tro-eh-sof-a-JEE-al REE-flux diz-EEZ) Also called GERD. A common disorder marked by frequentor severe heartburn. The burning feeling occurs when stomach acid flows upinto the esophagus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[25987] "Glaucoma; increased pressure in the eyeball due to obstruction of the outflow of aqueous humor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[25988] "an excess of neuroglia in damaged areas of the central nervous system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[25989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25990] "An enlarged thyroid. It may be caused by too little iodine in the diet or by other conditions. Most goiters are not cancer."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25991] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25993] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25994] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25995] "progressive ascending motor neuron paralysis of unknown etiology, frequently following an enteric or respiratory infection."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[25996] "Hemorrhage; flow of blood from a ruptured blood vessel."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[25997] "An enlarged or swollen blood vessel, usually located near the anus or the rectum."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[25998] "A condition in which some of the veins in the liver are blocked. It is sometimes a complication of high-dose chemotherapy given before a bone marrow transplant and is marked by increases in weight, liver size, and blood levels of bilirubin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[25999] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26001] "Abnormal enlargement of a kidney, which may be caused by blockage of the ureter (such as by a kidney stone) or chronic kidney disease that prevents urine from draining into the bladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[26002] "A high level of blood sugar.  It is usually an indication of diabetes mellitus. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[26003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26004] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26005] "A condition in which the production of thyroid hormone by the thyroid gland is diminished. Signs and symptoms of hypothyroidism include low metabolic rate, tendency to weight gain, somnolence and sometimes myxedema. In the United States, the most common cause of hypothyroidism is Hashimoto's thyroiditis, an autoimmune disorder. SYN athyrea. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[26006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26007] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26008] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26009] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26010] "Keratitis; inflammation of the cornea."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[26011] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26012] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26013] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26014] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26015] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26016] "Inflammation of the larynx."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26017] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26018] "A poorly defined concept which at best is described as an extremely rare entity, possibly related to various subtypes of acute myeloid leukemia with abnormal eosinophils.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[26019] "radiation induced progressive, malignant disease of the blood forming organs."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[26020] "demyelination in various part of the central nervous system, usually secondary to neoplastic disease; JC virus has been recovered from brain tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[26021] "(LOO-ko-PEE-nya) A condition in which the number of leukocytes (white blood cells) in the blood is reduced."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26022] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26023] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26024] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26025] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26026] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26027] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26028] "Lymphopenia; an abnormally small number of lymphocytes in the circulating blood."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26029] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26030] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26031] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26032] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26033] "Abnormally heavy menstrual bleeding."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[26034] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26035] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26036] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26037] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26038] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26039] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26040] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26041] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26042] "A metabolic bone disease that results from either a deficiency in vitamin D, or an abnormality in the metabolism of vitamin D, or a deficiency of calcium in the diet.  The most common symptoms are bone pain and muscle weakness.  When it occurs in children it is commonly referred to as rickets. (Diagnostic Surgical Pathology, 3rd ed.) --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[26043] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26044] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26045] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26046] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26047] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26048] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26049] "A progressive disorder of the nervous system marked by muscle tremors, muscle rigidity, decreased mobility, stooped posture, slow voluntary movements, and a mask-like facial expression."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[26050] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26051] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26052] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26053] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26054] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26055] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26056] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26057] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26058] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26059] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26060] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26061] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26062] "A condition in which the placenta is implanted in the lower part of the uterus. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[26063] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26064] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26065] "any of a group of lung diseases resulting from inhalation of particles of industrial substances."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26066] "clinical symptom complex characterized by presence of multiple cysts on the ovaries, oligomenorrhea or amenorrhea, anovulation and regularly associated with excessive amounts of body hair (hirsuitism), excessive body weight, infertility and insulin resistance."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[26067] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26068] "Inflammation of several peripheral nerves at the same time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26069] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26070] "Inflammation of the prostate gland."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[26071] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26072] "extravascular accumulation of fluid in the pulmonary tissue and air spaces."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26073] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26074] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26075] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26076] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26077] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26078] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26079] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26080] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26081] "A group of disorders marked by inflammation or pain in the connective tissue structures of the body. These structures include bone, cartilage, and fat."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[26082] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26083] "A non-neoplastic or neoplastic (benign or malignant) disorder involving the salivary gland. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[26084] "inflammation of the fallopian tubes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[26085] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26086] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26087] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26088] "cessation of breathing for 10 seconds or more during sleep and consequent oxygen desaturation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[26089] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26090] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26091] "Inflammation of the oral mucosa due to local or systemic factors. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[26092] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26093] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26094] "(throm-BOW-sis) The formation or presence of a blood clot inside a blood vessel."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26095] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26096] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26097] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26098] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26099] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26100] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26101] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26102] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26103] "genetic disease that produces sterile females due to monosomy for X chromosome; the ovaries are rudimentary or missing; other abnormalities include short stature, webbed neck, and a broad chest with widely spaced nipples."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[26104] "Redness of the skin."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[26105] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26106] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26107] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26108] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26109] "urination at short intervals; it may result from increased urine formation, decreased bladder capacity, or lower urinary tract irritation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[26110] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26111] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26112] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26113] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26114] "Vaginitis; inflammation of the vagina."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[26115] "Vasculitis; inflammation of a blood vessel."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26116] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26117] "abnormal development of secondary male sexual characteristics such as facial hair; in females, can be caused by androgen secretion by adrenal cortex."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[26118] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26119] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26120] "An oral condition in which salivary flow is reduced. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26121] "Renal syndrome in human immunodeficiency virus-infected patients characterized by nephrotic syndrome, severe proteinuria, focal and segmental glomerulosclerosis with distinctive tubular and interstitial changes, enlarged kidneys, and peculiar tubuloreticular structures. The syndrome is distinct from heroin-associated nephropathy as well as other forms of kidney disease seen in HIV-infected patients."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[26122] "An obsolete term for a malignant tumor of lymphatic tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26123] "A disorder of the brain that can be caused by disease, injury, drugs, or chemicals."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[26124] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26125] "The failure of the liver to detoxify chemicals in the body leading to a clinical disease"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[26126] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26127] "Irregular heart beat resulting from a pathologic process in the cardiac ventricles.--2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[26128] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26129] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26130] "Abnormal enlargement of the ureter caused by any blockage that prevents urine from draining into the bladder."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[26131] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26132] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26133] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26134] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26135] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26136] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26137] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26138] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26139] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26140] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26141] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26142] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26143] "Pain that can range from mild to severe, and persists or progresses over a long period of time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[26144] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26145] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26146] "Increase in the level of the enzyme gamma-glutamyltransferase in the blood, which catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, aminoacids, or water. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[26147] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26148] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26149] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26150] "An increase in the level of aspartate aminotransferase in the blood. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[26151] "An increase in the level of alanine aminotransferase in the blood. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[26152] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26153] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26154] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26155] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26156] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26157] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26158] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26159] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26160] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26161] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26162] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26163] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26164] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26165] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26166] "A change in skin color due to deposition of carotene."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[26167] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26168] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26169] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26170] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26171] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26172] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26173] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26174] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26175] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26176] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26177] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26178] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26179] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26180] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26181] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26182] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26183] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26184] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26185] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26186] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26187] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26188] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26189] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26190] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26191] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26192] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26193] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26194] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26195] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26196] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26197] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26198] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26199] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26200] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26201] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26202] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26203] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26204] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26205] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26206] "Pain that comes on quickly, can be severe, but lasts a relatively short time."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[26207] "Cancer that arises in cells that appear spindle-shaped when viewed under a microscope. These cancers can occur in various places in the body, including the skin, lungs, kidney, breast, gastrointestinal tract, bone, and muscle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[26208] "A malignant mesenchymal neoplasm composed of spindle-shaped cells.  This is a morphologic term which can be applied to a wide range of sarcomas. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[26209] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26210] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26211] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26212] "(my-AL-juh) Pain in a muscle or group of muscles."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[26213] "The inability to produce children."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[26214] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26215] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26216] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26217] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26218] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26219] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26220] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26221] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26222] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26223] "note that mammary disorders are not treed under this heading."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[26224] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26225] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26226] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26227] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26228] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26229] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26230] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26231] "An abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[26232] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26233] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26234] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26235] "The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. (LocusLink)"                                                                                                
[26236] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26237] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26238] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26239] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26240] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26241] "A syndrome characterized by persistent eosinophilia, for which no underlying cause can be found, and which is associated with signs of organ involvement and dysfunction.  This term has often been applied to cases of chronic eosinophilic leukemia.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26242] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26243] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26244] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26245] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26246] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26247] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26248] "Nodal arrhythmia is arrythmia occurring when the atrioventricular node or surrounding junctional tissue is acting as pacemaker."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[26249] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26250] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26251] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26252] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26253] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26254] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26255] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26256] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26257] "Discharge of blood from the anus. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[26258] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26259] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26260] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26261] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26262] "White matter changes first described in children with leukaemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterised by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation. (On-line Medical Dictionary)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[26263] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26264] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26265] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26266] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26267] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26268] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26269] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26270] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26271] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26272] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26273] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26274] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26275] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26276] "Injury to, or disease of, the cranial nerve"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26277] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26278] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26279] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26280] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26281] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26282] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26283] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26284] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26285] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26286] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26287] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26288] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26289] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26290] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26291] "Abnormally high level of bilirubin in the blood.  Excess bilirubin is associated with jaundice."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[26292] "A closed structure surrounded by a single membrane; any small pouch."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[26293] "A disease in which the function or structure of the affected tissues or organs changes for the worse over time.  Osteoarthritis, osteoporosis, and Alzheimer's disease are examples."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[26294] "Cancer that arises in cells that appear spindle-shaped when viewed under a microscope. These cancers can occur in various places in the body, including the skin, lungs, kidney, breast, gastrointestinal tract, bone, and muscle."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[26295] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26296] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26297] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26298] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26299] "Embryonal sarcoma is a rare malignant tumour of the liver, the incidence of which is highest in children between 6 and 10 years of age."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[26300] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26301] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26302] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26303] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26304] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26305] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26306] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26307] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26308] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26309] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26310] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26311] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26312] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26313] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26314] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26315] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26316] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26317] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26318] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26319] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26320] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26321] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26322] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26323] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26324] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26325] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26326] "Blurred vision is the loss of visual acuity (sharpness of vision) resulting in a loss of ability to see small details. (from MedlinePlus Medical Encyclopedia)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[26327] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26328] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26329] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26330] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26331] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26332] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26333] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26334] "Recently defined by Japanese researchers as a superficial carcinoma confined to the mucosa, or mucosa and submucosa, of the gastric wall.  The regional lymph nodes may or may not be involved.  Most cases occur in the distal third of the stomach.  The 5-year survival following resection is between 80% and 95%, and remains high even when lymph node metastases are present.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[26335] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26336] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26337] "Cancers of the blood or bone marrow, including leukemia and lymphoma. Also called hematologic cancers."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[26338] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26339] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26340] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26341] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26342] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26343] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26344] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26345] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26346] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26347] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26348] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26349] "An inherited deficiency of coagulation Factor VIII characterized by the tendency to spontaneous or exaggerated post-traumatic hemorrhage. Inherited as an x-linked recessive disease, hemophilia A is the most common hemophilia, occurring in approximately 1 in 10,000 male births. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[26350] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26351] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26352] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26353] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26354] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26355] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26356] "A chronic inflammatory connective tissue disease marked by skin rashes, joint pain and swelling, inflammation of the kidneys, inflammation of the fibrous tissue surrounding the heart (i.e., the pericardium), as well as other problems.  Not all affected individuals display all of these problems.  Also called systemic lupus erythematosus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[26357] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26358] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26359] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26360] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26361] "An arrhythmia originating from centers proximal to the ventricles, namely in the atrium, A-V node, or A-V junction, in contrast to arrhythmias arising in the ventricles themselves. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[26362] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26363] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26364] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26365] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26366] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26367] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26368] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26369] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26370] "a form of biliary cirrhosis in which small intrahepatic ducts are destroyed while the major intra and extra hepatic ducts remain patent; most patients are middle aged females and have circulating antimitochondrial antibodies."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[26371] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26372] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26373] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26374] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26375] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26376] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26377] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26378] "Neoplasm that is growing at a faster rate"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[26379] "A condition marked by pain, swelling, numbness, tingling, or redness of the hands or feet. It sometimes occurs as a side effect of certain anticancer drugs. Also known as hand-foot syndrome."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[26380] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26381] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26382] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26383] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26384] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26385] "A rare spinal tumor which is highly malignant and tends to be locally invasive of surrounding neural tissue.  The tumor also tends to spread throughout the neuroaxis and is often rapidly progressive.  Histologically the tumors are highly cellular with nuclear and cellular pleomorphism, endothelial proliferation, mitotic figures, and, often, necrosis . This tumor has a relatively poor prognosis.  Clinical features may include pain followed by rapidly progressive neurologic deficits such as extremity weakness, sensory changes, spasticity, and incontinence. (From Innocenzi et al., Clin Neurol Neurosurg 1997 Feb;99(1):1-5)"                                                                                                                                                                                                                                                                                                                                                 
[26386] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26387] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26388] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26389] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26390] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26391] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26392] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26393] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26394] "Inflammation of the intestines, but usually only of the small intestine.  Regional enteritis increases the risk for developing colon cancer.  Also called Crohn's disease."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[26395] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26396] "(BRAY-kee-ul pleks-AH-pah-thee) A condition marked by numbness, tingling, pain, weakness, or limited movement in the arm or hand. It is caused by an impairment of the brachial plexus, a network of nerves that affect the arm and hand."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[26397] "A disorder of the skin marked by inflammation of oil glands and hair glands."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[26398] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26399] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26400] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26401] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26402] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26403] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26404] "A papillary bladder carcinoma which is not confined to the urothelium, extending at least into the lamina propria. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[26405] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26406] "A term previously used to describe chronic diseases of the connective tissue (e.g., rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis), but now is thought to be more appropriate for diseases associated with defects in collagen, which is a component of the connective tissue."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26407] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26408] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26409] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26410] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26411] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26412] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26413] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26414] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26415] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26416] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26417] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26418] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26419] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26420] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26421] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26422] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26423] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26424] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26425] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26426] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26427] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26428] "aspects of female morphology in a XY genotype."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[26429] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26430] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26431] "Damage to DNA caused by ionizing radiation.  Can cause base change mutations or strand breakage."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26432] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26433] "Patient complaints (symptoms), physical/laboratory findings(signs) related to the cardiovascular system."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[26434] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26435] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26436] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26437] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26438] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26439] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26440] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26441] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26442] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26443] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26444] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26445] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26446] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26447] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26448] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26449] "Cancer has spread beyond the urethra, vagina, and anus into the lining of the bladder (the sac that holds urine) and the bowel (intestine); or it may have spread to the lymph nodes in the pelvis or to other parts of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[26450] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26451] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26452] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26453] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26454] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26455] "A benign, well-circumscribed renal cortical neoplasm affecting females more often than males.  Polycythemia has been reported in as many as 12% of patients. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[26456] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26457] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26458] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26459] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26460] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26461] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26462] "A dendritic cell neoplasm that does not fall into well-defined categories.  Such tumors have been called indeterminate cell sarcomas.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[26463] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26464] "A category of clonal myeloid disorders that have both myelodysplastic and chronic myeloproliferative features at the time of initial presentation.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
[26465] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26466] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26467] "Antiquated term describing non-Hodgkin's lymphomas that are usually diffuse and are composed of large cells with irregular nuclei, invisible nucleoli and a small amount of cytoplasm.  This morphologic category includes both mature B- and mature T-cell lymphomas.--2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
[26468] "Antiquated term for diffuse non-Hodgkin's lymphomas composed of non-cleaved cells.  The vast majority of cases are mature B-cell lymphomas (Burkitts or diffuse large B-cell lymphomas).--2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[26469] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26470] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26471] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26472] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26473] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26474] "Antiquated term describing follicular (nodular) or diffuse non-Hodgkin's lymphomas that are composed of a mixture of large cells: large cleaved cells, with irregular nuclei without visible nucleoli; and large non-cleaved cells (centroblasts), having a rounder nucleus with two to three small, peripherally placed nucleoli and a small amount of basophilic cytoplasm.  The follicular variants represent mature B-cell lymphomas, whereas the diffuse variants can be either mature B- or mature T-cell lymphomas. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[26475] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26476] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26477] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26478] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26479] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26480] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26481] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26482] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26483] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26484] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26485] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26486] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26487] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26488] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26489] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26490] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26491] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26492] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26493] "A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells.  Ewing's sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing's sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor.  Ewing's sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities.  These tumors may occur in the soft tissues or the bones.  Pain and the presence of a mass are the most common clinical symptoms. -- 2004"                                                                                                                                                                                                                                                                         
[26494] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26495] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26496] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26497] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26498] "Cancer that has spread to the lymph nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[26499] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26500] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26501] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26502] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26503] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26504] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26505] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26506] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26507] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26508] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26509] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26510] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26511] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26512] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26513] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26514] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26515] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26516] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26517] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26518] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26519] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26520] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26521] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26522] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26523] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26524] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26525] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26526] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26527] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26528] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26529] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26530] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26531] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26532] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26533] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26534] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26535] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26536] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26537] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26538] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26539] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26540] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26541] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26542] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26543] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26544] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26545] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26546] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26547] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26548] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26549] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26550] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26551] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26552] "This subgroup of chronic myeloproliferative disorders includes cases which do not meet the morphologic criteria of any of the defined chronic myeloproliferative disorders, or which have characteristics that overlap at least two of the chronic myeloproliferative disorders."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26553] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26554] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26555] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26556] "The reemergence of peripheral neuroepithelioma of bone after a period of remission"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[26557] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26558] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26559] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26560] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26561] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26562] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26563] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26564] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26565] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26566] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26567] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26568] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26569] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26570] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26571] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26572] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26573] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26574] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26575] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26576] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26577] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26578] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26579] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26580] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26581] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26582] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26583] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26584] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26585] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26586] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26587] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26588] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26589] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26590] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26591] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26592] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26593] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26594] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26595] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26596] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26597] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26598] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26599] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26600] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26601] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26602] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26603] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26604] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26605] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26606] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26607] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26608] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26609] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26610] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26611] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26612] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26613] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26614] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26615] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26616] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26617] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26618] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26619] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26620] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26621] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26622] "A rare variant of esophageal squamous cell carcinoma.  It is an exophytic, cauliflower-like or papillary mass that can arise in any part of the esophagus.  This variant of squamous cell carcinoma grows slowly and invades locally, with a very low metastasizing potential.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
[26623] "A carcinoma that has a significant squamous carcinomatous component that is intermingled with an adenocarcinoma.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
[26624] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26625] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26626] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26627] "A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal mucosa.  It includes lesions termed moderate dysplasia, and carcinoma in situ (severe dysplasia).  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[26628] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26629] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26630] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26631] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26632] "Located most frequently in the lower esophagus and begin as intramural lesions.  Predominantly occurs in older males.  Dysphagia is the usual complaint.  Most tumors are clinically malignant, and commonly develop liver metastases.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26633] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26634] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26635] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26636] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26637] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26638] "A lesion also known as mild dysplasia, shows a mildly modified mucosal architecture, including the presence of tubular structures with budding and branching, papillary enfolding, crypt lengthening, and cystic changes.  (WHO, 2000) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[26639] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26640] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26641] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26642] "Mantle cell lymphoma of the stomach is most often a component of multifocal lymphomatous polyposis of the gastrointestinal tract and it usually has an aggressive clinical course.  -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26643] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26644] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26645] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26646] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26647] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26648] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26649] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26650] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26651] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26652] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26653] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26654] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26655] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26656] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26657] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26658] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26659] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26660] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26661] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26662] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26663] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26664] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26665] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26666] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26667] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26668] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26669] "Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[26670] "A plasma cell disorder in which an abnormal amount of a single immunoglobulin is present in the serum. Paraproteinemias may be seen in conjunction with various carcinomas, chronic inflammatory and infectious conditions, and other diseases. --2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[26671] "Carcinoma that is spread throughout the body, a metastatic phenomenon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[26672] "Carcinoma that is spread throughout the body, a metastatic phenomenon."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[26673] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26674] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26675] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26676] "Superficial Bladder Cancer is a term used by urologists to describe infiltrating carcinomas that have not invaded into the muscularis propia of the urinary bladder wall regardless of their histologic type or grade, and therefore it does not represent a pathologic entity.  It is important for the term stage 0is bladder cancer (carcinoma in situ of the bladder) not to be equated with superficial bladder cancer.  Stage I bladder cancer may be considered superficial. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[26677] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26678] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26679] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26680] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26681] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26682] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26683] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26684] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26685] "This type of lipoma occurs in the extremities of young children (usually boys).  The lesion is characterized by lobules of mature adipose (fatty) tissue, separated by fibrous septa.  Scattered developing lipoblasts may be seen. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26686] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26687] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26688] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26689] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26690] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26691] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26692] "An adult Hodgkin's lymphoma (PDQ)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[26693] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26694] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26695] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26696] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26697] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26698] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26699] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26700] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26701] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26702] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26703] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26704] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26705] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26706] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26707] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26708] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26709] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26710] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26711] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26712] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26713] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26714] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26715] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26716] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26717] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26718] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26719] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26720] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26721] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26722] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26723] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26724] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26725] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26726] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26727] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26728] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26729] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26730] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26731] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26732] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26733] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26734] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26735] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26736] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26737] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26738] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26739] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26740] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26741] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26742] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26743] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26744] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26745] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26746] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26747] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26748] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26749] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26750] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26751] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26752] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26753] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26754] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26755] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26756] "A disorder involving lesions or eruptions of the skin, usually without inflammation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[26757] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26758] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26759] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26760] "Mitelman_Code: 201"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[26761] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26762] "a condition of the newborn marked by dyspnea with cyanosis, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, most frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
[26763] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26764] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26765] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26766] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26767] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26768] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26769] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26770] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26771] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26772] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26773] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26774] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26775] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26776] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26777] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26778] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26779] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26780] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26781] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26782] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26783] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26784] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26785] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26786] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26787] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26788] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26789] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26790] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26791] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26792] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26793] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26794] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26795] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26796] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26797] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26798] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26799] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26800] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26801] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26802] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26803] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26804] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26805] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26806] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26807] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26808] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26809] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26810] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26811] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26812] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26813] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26814] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26815] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26816] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26817] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26818] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26819] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26820] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26821] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26822] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26823] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26824] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26825] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26826] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26827] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26828] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26829] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26830] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26831] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26832] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26833] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26834] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26835] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26836] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26837] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26838] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26839] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26840] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26841] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26842] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26843] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26844] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26845] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26846] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26847] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26848] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26849] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26850] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26851] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26852] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26853] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26854] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26855] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26856] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26857] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26858] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26859] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26860] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26861] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26862] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26863] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26864] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26865] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26866] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26867] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26868] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26869] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26870] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26871] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26872] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26873] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26874] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26875] "This category currently includes only malignancies in which there is a well documented association between the neoplastic process and a specific virus as a causative agent.--2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[26876] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26877] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26878] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26879] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26880] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26881] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26882] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26883] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26884] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26885] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26886] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26887] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26888] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26889] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26890] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26891] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26892] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26893] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26894] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26895] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26896] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26897] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26898] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26899] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26900] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26901] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26902] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26903] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26904] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26905] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26906] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26907] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26908] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26909] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26910] "(sam-O-ma) Structures found in some benign (noncancerous) or malignant (cancerous) tumor cells that look like hardened concentric rings when viewed under a microscope.  Can be a sign of chronic inflammation."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[26911] "Non-small cell lung cancer that originates in the upper portion of the lung and extends to other nearby tissues such as the ribs and vertebrae. Also called a Pancoast tumor."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[26912] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26913] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26914] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26915] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26916] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26917] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26918] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26919] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26920] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26921] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26922] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26923] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26924] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26925] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26926] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26927] "A myelodysplastic syndrome characterized by bi-cytopenia or pancytopenia, dysplastic changes in 10% or more of the cells in two or more of the myeloid cell lines, and 15% or more ringed sideroblasts in the bone marrow.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[26928] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26929] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26930] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26931] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26932] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26933] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26934] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26935] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26936] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26937] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26938] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26939] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26940] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26941] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26942] "A process that involves either a blood clot or bleeding, such as a heart attack or stroke."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
[26943] "Melanoma in which the tumor is more than 4 millimeters thick. It has spread through the lower part of the inner layer of skin (dermis) and into subcutaneous (under the skin) tissue, but not to nearby lymph nodes."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
[26944] "(SOM-no-lens) Periods of drowsiness, lethargy, loss of appetite, and irritability in children following radiation therapy treatments to the head."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[26945] "(pleks-AH-pah-thee) A disorder affecting a network of nerves, blood vessels, or lymph vessels."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[26946] "(ADD-in-o-KAR-sin-O-ma) A type of cancer that begins in the glandular cells that line certain internal organs and most commonly affects the lungs. It is diagnosed by the way the cells appear under a microscope."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[26947] "Having too little oxygen."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[26948] "(IM-po-tent) Unable to have an erection adequate for sexual intercourse."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[26949] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26950] "A skin disease marked by scaly or thickened patches on the skin, and often caused by prolonged exposure to arsenic.  The patches often occur on sunexposed areas of the skin and in older white men.  These patches may become malignant (cancerous).  Also called Bowen's disease or precancerous dermatitis."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[26951] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26952] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26953] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26954] "This category of acute myeloid leukemias is morphology based and reflects the morphologic subtypes present in the French-American-British (FAB) classification scheme.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26955] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26956] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26957] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26958] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26959] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26960] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26961] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26962] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26963] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26964] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26965] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26966] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26967] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26968] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26969] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26970] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26971] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26972] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26973] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26974] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26975] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26976] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26977] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26978] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26979] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26980] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26981] "This entity includes cases that have clinical, laboratory, and morphologic features that support the diagnosis of both a myelodysplastic syndrome and a chronic myeloproliferative disorder, but do not meet the criteria for any of the other entities included in the myelodysplastic/myeloproliferative disease category.  (WHO, 2001) -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
[26982] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26983] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26984] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26985] "Stage IV includes: (T4, Any N, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades other adjacent structures.  N3: Metastasis in deep inguinal or pelvic lymph node(s) unilateral or bilateral.  M1: Distant metastasis.  (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[26986] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26987] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26988] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26989] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26990] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26991] "Stage 0 includes: (Tis, N0, M0) and (Ta, N0, M0).  Tis: Carcinoma in situ.  Ta: Non-invasive verrucous carcinoma.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[26992] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26993] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26994] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26995] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26996] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26997] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26998] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[26999] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27000] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27001] "(mye-KO-sis fun-GOY-deez)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
[27002] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27003] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27004] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27005] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27006] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27007] "A renal cell cancer that has invaded the renal capsule and has spread to lymph nodes and other anatomic sites.  Metastatic renal cell cancer is stage IV, but stage IV includes some non-metastatic tumors, e.g. T4 M0. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
[27008] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27009] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27010] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27011] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27012] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27013] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27014] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27015] "A malignant tumor arising from the epithelium of the intrahepatic or extrahepatic bile duct.  Intrahepatic bile duct carcinomas are adenocarcinomas and are called cholangiocarcinomas.  Extrahepatic bile duct carcinomas are adenocarcinomas, adenosquamous carcinomas, squamous cell carcinomas, small cell carcinomas, or mucoepidermoid carcinomas. -- 2004"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27016] "Primary or metastatic malignant neoplasm involving the endometrium (mucous membrane that lines the endometrial cavity).  --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
[27017] "A nevus characterised by the presence of excessive pigment. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[27018] "A premalignant condition morphologically characterised by the presence of the characteristic Paget's cells in the intraepithelial tissue of the penis.  It presents as a smooth raised reddish area that may or may not be painful. -- 2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
[27019] "Abnormal malignant growth of cells in the ureter (upper urinary tract)that has progressed to involve other areas of the body."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[27020] "Abnormal malignant growth of cells in the urethra (lower urinary tract)that has spread either into adjacent tissue or to a distant site."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
[27021] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27022] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27023] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27024] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27025] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27026] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27027] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27028] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27029] "Stage IIIC Breast Cancer was added in the 6th Edition AJCC Staging Manual, on the basis of metastasis to the infraclavicular lymph nodes (N3) plus any T, M0."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
[27030] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27031] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27032] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27033] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27034] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27035] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27036] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27037] "This is a condition that predisposes to gastric mucosa-associated lymphoid tissue lymphoma. --2003"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
[27038] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27039] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27040] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27041] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27042] NA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
[27043] NA                                                            